FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Bartolucci, SF Kaplan, D Maurer, JA AF Bartolucci, Stephen F. Kaplan, Daniel Maurer, Joshua A. TI Ion beam-induced hydroxylation controls molybdenum disulfide growth SO 2D MATERIALS LA English DT Article DE 2D materials; transition metal dichalcogenide; molybdenum disulfide; surface hydroxylation; focused ion beam (FIB) ID CHEMICAL-VAPOR-DEPOSITION; TRANSITION-METAL DICHALCOGENIDES; INORGANIC FULLERENES; MOS2 TRANSISTORS; ATOMIC LAYERS; PHASE GROWTH; CRYSTALLINE; MONOLAYERS; SURFACE; MODEL AB 2D materials, such as graphene and transition metal dichalcogenides, are a promising class of nanomaterials for next generation electronics, photovoltaics, electrocatalysts, sensors, and optoelectronic devices. Molybdenum disulfide (MoS2) is of particular interest due to its direct bandgap in the visible spectrum, high electron mobility, and chemical stability. Here, we demonstrate that alterations in the density of surface hydroxyl groups on silicon dioxide substrates can control nucleation and growth in molybdenum disulfide thin films produced by atmospheric-pressure chemical vapor deposition. The extent of MoS2 nucleation is linearly correlated to the density of surface hydroxyl groups. Controlling the density of surface hydroxyl groups on the initial substrate provides a method of growing patterned molybdenum disulfide. Furthermore, we establish that the surface density of hydroxyl groups on silicon dioxide (SiO2) is altered using conventional gallium focused ion beam (FIB) patterning. Upon gallium-ion beam exposure, the number of hydroxyl groups generated on the surface is directly proportional to the ion dosage. This work establishes a means of patterning large-area monolayer MoS2 on silicon dioxide substrates, which is a critical step for realizing applications in imaging, catalysis, biosensing, chemical detection, electronics and optoelectronics. C1 [Bartolucci, Stephen F.; Maurer, Joshua A.] US Army, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA. [Kaplan, Daniel] US Army, Armaments Res Dev & Engn Ctr, Dover, NJ 07806 USA. RP Bartolucci, SF (reprint author), US Army, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA. EM stephen.f.bartolucci.civ@mail.mil; joshua.a.maurer4.civ@mail.mil FU US Army In-House Laboratory Independent Research program FX This work was funded by the US Army In-House Laboratory Independent Research program. NR 32 TC 0 Z9 0 U1 6 U2 6 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 2053-1583 J9 2D MATER JI 2D Mater. PD JUN PY 2017 VL 4 IS 2 AR 021017 DI 10.1088/2053-1583/aa5e7e PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA EN4QE UT WOS:000395991200001 ER PT J AU Kessler, RC Stein, MB Petukhova, MV Bliese, P Bossarte, RM Bromet, EJ Fullerton, CS Gilman, SE Ivany, C Lewandowski-Romps, L Bell, AM Naifeh, JA Nock, MK Reis, BY Rosellini, AJ Sampson, NA Zaslavsky, AM Ursano, RJ AF Kessler, R. C. Stein, M. B. Petukhova, M. V. Bliese, P. Bossarte, R. M. Bromet, E. J. Fullerton, C. S. Gilman, S. E. Ivany, C. Lewandowski-Romps, L. Bell, A. Millikan Naifeh, J. A. Nock, M. K. Reis, B. Y. Rosellini, A. J. Sampson, N. A. Zaslavsky, A. M. Ursano, R. J. CA Army STARRS Collaborators TI Predicting suicides after outpatient mental health visits in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) SO MOLECULAR PSYCHIATRY LA English DT Article ID TRAUMATIC BRAIN-INJURY; US ARMY; SOLDIERS; MILITARY; DEATH; CARE; PREVENTION; DEPRESSION; ATTEMPTORS; DEPLOYMENT AB The 2013 US Veterans Administration/Department of Defense Clinical Practice Guidelines (VA/DoD CPG) require comprehensive suicide risk assessments for VA/DoD patients with mental disorders but provide minimal guidance on how to carry out these assessments. Given that clinician-based assessments are not known to be strong predictors of suicide, we investigated whether a precision medicine model using administrative data after outpatient mental health specialty visits could be developed to predict suicides among outpatients. We focused on male nondeployed Regular US Army soldiers because they account for the vast majority of such suicides. Four machine learning classifiers (naive Bayes, random forests, support vector regression and elastic net penalized regression) were explored. Of the Army suicides in 2004-2009, 41.5% occurred among 12.0% of soldiers seen as outpatient by mental health specialists, with risk especially high within 26 weeks of visits. An elastic net classifier with 10-14 predictors optimized sensitivity (45.6% of suicide deaths occurring after the 15% of visits with highest predicted risk). Good model stability was found for a model using 2004-2007 data to predict 2008-2009 suicides, although stability decreased in a model using 2008-2009 data to predict 2010-2012 suicides. The 5% of visits with highest risk included only 0.1% of soldiers (1047.1 suicides/100 000 person-years in the 5 weeks after the visit). This is a high enough concentration of risk to have implications for targeting preventive interventions. An even better model might be developed in the future by including the enriched information on clinician-evaluated suicide risk mandated by the VA/DoD CPG to be recorded. C1 [Kessler, R. C.; Petukhova, M. V.; Rosellini, A. J.; Sampson, N. A.; Zaslavsky, A. M.] Harvard Med Sch, Dept Hlth Care Policy, Boston, MA USA. [Stein, M. B.] Univ Calif San Diego, Dept Psychiat & Family & Prevent Med, La Jolla, CA USA. [Stein, M. B.] VA San Diego Healthcare Syst, San Diego, CA USA. [Bliese, P.] Univ South Carolina, Darla Moore Sch Business, Columbia, SC USA. [Bossarte, R. M.] Post Deployment Hlth Serv, Dept Vet Affairs, Washington, DC USA. [Bromet, E. J.] Stony Brook Sch Med, Dept Psychiat & Behav Sci, Stony Brook, NY USA. [Fullerton, C. S.; Naifeh, J. A.; Ursano, R. J.] Uniformed Serv Univ Hlth Sci, Sch Med, Ctr Study Traumat Stress, Dept Psychiat, Bethesda, MD USA. [Gilman, S. E.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Intramural Populat Hlth Res, Hlth Behav Branch, Bethesda, MD USA. [Gilman, S. E.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol & Social & Behav Sci, Boston, MA USA. [Ivany, C.] US Army Med Command, Behav Hlth Serv Line, Bethesda, MD USA. [Lewandowski-Romps, L.] Univ Michigan, Inst Social Res, Ann Arbor, MI USA. [Bell, A. Millikan] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Nock, M. K.] Harvard Univ, Dept Psychol, Cambridge, MA USA. [Reis, B. Y.] Childrens Hosp Boston, Harvard Med Sch, Boston, MA USA. RP Kessler, RC (reprint author), Harvard Med Sch, Dept Hlth Care Policy, Boston, MA 02115 USA. EM Kessler@hcp.med.harvard.edu OI Gilman, Stephen/0000-0002-8331-6419 FU Department of the Army; US Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health (NIH/NIMH) [U01MH087981]; Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development FX Army STARRS was sponsored by the Department of the Army and funded under cooperative agreement number U01MH087981 with the US Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health (NIH/NIMH). Dr Gilman's participation in this work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. We thank Kenneth L Cox for helpful comments on an earlier version of this paper. Although a draft of this manuscript was submitted to the Army and NIMH for review and comment before submission, this was with the understanding that comments would be no more than advisory. NR 48 TC 1 Z9 1 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1359-4184 EI 1476-5578 J9 MOL PSYCHIATR JI Mol. Psychiatr. PD APR PY 2017 VL 22 IS 4 BP 544 EP 551 DI 10.1038/mp.2016.110 PG 8 WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry GA EP0TP UT WOS:000397099900008 PM 27431294 ER PT J AU Holman, RA Brodie, KL Spore, NJ AF Holman, Rob A. Brodie, Katherine L. Spore, Nicholas J., Jr. TI Surf Zone Characterization Using a Small Quadcopter: Technical Issues and Procedures SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Argus; nearshore remote sensing; surf zone; unmanned aerial vehicle (UAV) AB We explore the potential for using a small unmanned aerial vehicle (UAV) quadcopter to collect long-dwell imagery of the nearshore from which important measurements can be made at low cost and with flexibility. This paper extends the existing topographic imaging approaches that rely on having plentiful ground control spread across the image, to the nearshore case where the bulk of the image is water with no control point and vehicle metadata must be used. The UAV autopilot was found to be capable of excellent station-keeping with the positional errors of 0.20 and 0.53 m (horizontal and vertical) and the viewing angle errors of 0.25 degrees (tilt and roll) and 0.38 degrees (azimuth). The ground position of imaged objects could be found with 0.21-m accuracy. Metadata returned by the UAV on camera position was accurate at 5 m, and the camera roll could be assumed to be 0 degrees, reducing the ground control requirements to two, or even one location. Even under this extreme simplification, ground position errors averaged only 10 m but were worse for cases when only control points near to the UAV were used. A model for the visual contrast of waves when viewed from different angles found that large tilts are important but, in contrast to theory, that there was little dependence on the viewing azimuthal angle. Derived Argus products agreed well with the same products collected using a traditional fixed Argus station. UAVs appear to be a very promising alternate to fixed camera systems if limited duration sampling is adequate. C1 [Holman, Rob A.] Oregon State Univ, Coll Earth Ocean & Atmospher Sci, Corvallis, OR 97331 USA. [Brodie, Katherine L.; Spore, Nicholas J., Jr.] US Army Corps Engineers, Field Res Facil, Kitty Hawk, NC 27949 USA. RP Holman, RA (reprint author), Oregon State Univ, Coll Earth Ocean & Atmospher Sci, Corvallis, OR 97331 USA. EM holman@coas.oregonstate.edu; katherine.l.brodie@usace.army.mil; nicholas.j.spore@erdc.dren.mil FU USACE Coastal Field Data Collection Program; Office of Naval Research [N00014-10-1-0932] FX This work was supported by the Assistant Secretary of the Army for Acquisition, Logistics and Technology, Military Engineering RDT&E 6.2 and 6.3 Austere Entry Programs and by the USACE Coastal Field Data Collection Program. The work of R. A. Holman was supported by the Office of Naval Research under Grant N00014-10-1-0932. NR 14 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD APR PY 2017 VL 55 IS 4 BP 2017 EP 2027 DI 10.1109/TGRS.2016.2635120 PG 11 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA EO0NN UT WOS:000396394900014 ER PT J AU Swearingen, ME Horvath, R White, MJ AF Swearingen, Michelle E. Horvath, Rachael White, Michael J. TI Climate analysis for noise assessment SO APPLIED ACOUSTICS LA English DT Article DE Acoustic climate ID SOUND-PROPAGATION AB Long-term noise assessments are performed as part of the National Environmental Policy Act (NEPA) process prior to construction of facilities or significant changes to operations on military installations. In the past, these assessments have been based on a single, typical or average propagation condition. ISO 13474 dictates that a weighted set of propagation condition-specific tables shall be used within the noise assessment. In this paper we explore the differences between noise assessments using local conditions and the averaged condition. We found that the assessed annual C-weighted sound exposure level (CSEL) using conditions for seven geographically different locations differed by up to 3 dB in the four cardinal directions for distances up to 10 km, indicating that an average propagation condition may be satisfactory for most locations. Published by Elsevier Ltd. C1 [Swearingen, Michelle E.; Horvath, Rachael; White, Michael J.] US Army, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. RP Swearingen, ME (reprint author), US Army, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. EM michelle.e.swearingen@usace.army.mil FU U.S. Army Engineer Research and Development Center Environmental Quality and Installations program FX Funding was provided by the U.S. Army Engineer Research and Development Center Environmental Quality and Installations program. Distribution Statement A Approved for Public Release; distribution unlimited. NR 12 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-682X EI 1872-910X J9 APPL ACOUST JI Appl. Acoust. PD APR PY 2017 VL 119 BP 50 EP 56 DI 10.1016/j.apacoust.2016.12.008 PG 7 WC Acoustics SC Acoustics GA EJ5MI UT WOS:000393261900006 ER PT J AU Albert, DG Decato, SN AF Albert, Donald G. Decato, Stephen N. TI Acoustic and seismic ambient noise measurements in urban and rural areas SO APPLIED ACOUSTICS LA English DT Article DE Urban ambient noise; Seismic noise; Acoustic noise; Geophone ID HIGH-FREQUENCY; TRAFFIC NOISE; UNITED-STATES; BACKGROUND-NOISE; HONG-KONG; ENVIRONMENT; RESOLUTION; SURFACE; DEPTH; MODEL AB Using portable sound level meters, simultaneous one-third octave spectral measurements of acoustic and seismic ambient noise as a function of frequency were conducted in different urban terrains and at two rural locations. The acoustic measurement frequency band of 6 Hz-20 kHz includes frequencies lower than are commonly measured in acoustic surveys, while the seismic band of 6 Hz-1 kHz extends to higher frequencies than most past seismic measurements. The urban acoustic measurements are dominated by traffic noise. The seismic signatures also are heavily influenced by traffic noise but exhibit more variation with respect to urban location due to the influence of subsurface conditions. For most urban measurement sites, the acoustic peak frequency was usually around 60 Hz, while the peak seismic frequencies were usually less than 25 Hz. The measured urban seismic spectra also tended to have more structure and variation in spectral shape from one location to another compared to the acoustic spectra, and a more rapid decline with increasing frequency, usually decreasing by about 30 dB from 30 Hz to 600 Hz. Published by Elsevier Ltd. C1 [Albert, Donald G.; Decato, Stephen N.] Cold Reg Res & Engn Lab ERDC CRREL, Engn Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03750 USA. RP Albert, DG (reprint author), Cold Reg Res & Engn Lab ERDC CRREL, Engn Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03750 USA. EM Donald.G.Albert@usace.army.mil; cotbsd@gmail.com FU US Department of Defense Urban Operations Focus Area Collaborative Team (UO FACT); (US Army) Engineer Research and Development Center (ERDC) applied research projects FX This research was funded by a grant from the US Department of Defense Urban Operations Focus Area Collaborative Team (UO FACT) and by (US Army) Engineer Research and Development Center (ERDC) applied research projects. We thank Frank E. Perron, Jr. for assistance with the rural noise measurements in Pomfret, VT, and Mr. Leon Stetson for allowing us to use the Pomfret site. Unpublished oral presentations by Mr. David F. Fordyce and Ms. Kathy Luft of USAMSAA (US Army Materiel Systems Analysis Activity) on urban terrain zones were helpful to our understanding of this categorization system. We also thank the two anonymous reviewers for their helpful comments. Permission to publish was granted by the Director, Cold Regions Research and Engineering Laboratory. NR 36 TC 0 Z9 0 U1 5 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-682X EI 1872-910X J9 APPL ACOUST JI Appl. Acoust. PD APR PY 2017 VL 119 BP 135 EP 143 DI 10.1016/j.apacoust.2016.12.015 PG 9 WC Acoustics SC Acoustics GA EJ5MI UT WOS:000393261900016 ER PT J AU Hogan, JD Farbaniec, L Mallick, D Domnich, V Kuwelkar, K Sano, T McCauley, JW Ramesh, KT AF Hogan, James David Farbaniec, Lukasz Mallick, Debjoy Domnich, Vladislav Kuwelkar, Kanak Sano, Tomoko McCauley, James W. Ramesh, Kaliat T. TI Fragmentation of an advanced ceramic under ballistic impact: Mechanisms and microstructure SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Impact fragmentation; Brittle failure; Advanced ceramics; Boron carbide; Defects ID BORON-CARBIDE; PENETRATION; FAILURE AB In this paper, the impact-induced fragmentation of a commercially available hot-pressed boron carbide is explored. Fragmentation has been noted previously by many authors to be important in the impact performance of advanced ceramics, and so this paper seeks to provide some of the first near-complete and detailed measurements of individual fragment size and shape distributions available in the literature. Fragment size and shapes are quantified using methods developed in previous papers by the authors, and results reveal that two distinct fragmentation mechanisms exist as a consequence of the impact failure of boron carbide: one mechanism that creates small fragments that is associated with the coalescence of fractures originating from carbonaceous defects in the material, and one that creates larger fragments that is associated with structural failure (e.g., radial and circumferential cracking). While these mechanisms are similar to those noted for uniaxial compressive failure, results presented here highlight the importance of fragment shape as a consequence of impact failure. Namely, results indicate that both blocky and shard fragments are formed during impact into a boron carbide plate. Blocky and shard fragment types span across both the small and large fragmentation mechanisms. Using Scanning Electron Microscopy, blocky fragments were found to be associated with the predominant growth of cracks parallel to the impact direction, while shard fragments contain fracture surfaces that are associated with crack growth and coalescence in a direction perpendicular to the impact direction. The shards are, thus, believed to be a consdquence of structural bending. No amorphous features were found on any blocky or shard fragments observed in this study (determined using Raman Spectroscopy), suggesting brittle fracture may be the dominant mechanisms that creates the shard fragments. Altogether, the implications of these results is that one can control fragment size and shape by controlling the carbonaceous defects population in boron carbide. This should help in the design of next-generation advanced ceramics for personal protection. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Hogan, James David] Univ Alberta, Dept Mech Engn, Edmonton, AB T6G 2R3, Canada. [Hogan, James David; Farbaniec, Lukasz; Mallick, Debjoy; McCauley, James W.; Ramesh, Kaliat T.] Johns Hopkins Univ, Hopkins Extreme Mat Inst, Baltimore, MD 21218 USA. [Farbaniec, Lukasz] Imperial Coll London, Inst Shock Phys, London SW7 2AZ, England. [Mallick, Debjoy; Sano, Tomoko; McCauley, James W.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Domnich, Vladislav; Kuwelkar, Kanak] Rutgers State Univ, Dept Mat Sci & Engn, Piscataway, NJ 08854 USA. [Ramesh, Kaliat T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. RP Hogan, JD (reprint author), Univ Alberta, Dept Mech Engn, Edmonton, AB T6G 2R3, Canada.; Hogan, JD (reprint author), Johns Hopkins Univ, Hopkins Extreme Mat Inst, Baltimore, MD 21218 USA. EM jdhogan@uablerta.ca OI Hogan, James/0000-0002-9212-9252 FU US Army Research Laboratory [W911NF-12-2-0022, W911NF-16-2-0079] FX This research was sponsored by the US Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0022 and W911NF-16-2-0079. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. We acknowledge Dr. Brian Schuster of US Army Research Laboratory for access to the impact facility. Jim Campbell is also thanked for his review. NR 24 TC 0 Z9 0 U1 5 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD APR PY 2017 VL 102 BP 47 EP 54 DI 10.1016/j.ijimpeng.2016.12.008 PG 8 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA EJ1WP UT WOS:000393001400005 ER PT J AU Salje, H Lessler, J Berry, IM Melendrez, MC Endy, T Kalayanarooj, S A-Nuegoonpipat, A Chanama, S Sangkijporn, S Klungthong, C Thaisomboonsuk, B Nisalak, A Gibbons, RV Iamsirithaworn, S Macareo, LR Yoon, IK Sangarsang, A Jarman, RG Cummings, DAT AF Salje, Henrik Lessler, Justin Berry, Irina Maljkovic Melendrez, Melanie C. Endy, Timothy Kalayanarooj, Siripen A-Nuegoonpipat, Atchareeya Chanama, Sumalee Sangkijporn, Somchai Klungthong, Chonticha Thaisomboonsuk, Butsaya Nisalak, Ananda Gibbons, Robert V. Iamsirithaworn, Sopon Macareo, Louis R. Yoon, In-Kyu Sangarsang, Areerat Jarman, Richard G. Cummings, Derek A. T. TI DENGUE VIRUS Dengue diversity across spatial and temporal scales: Local structure and the effect of host population size SO SCIENCE LA English DT Article ID SOUTHEAST-ASIA; KAMPHAENG-PHET; TRANSMISSION; THAILAND; DYNAMICS; BURDEN; SPREAD; MIGRATION; CHILDREN; VILLAGES AB A fundamental mystery for dengue and other infectious pathogens is how observed patterns of cases relate to actual chains of individual transmission events. These pathways are intimately tied to the mechanisms by which strains interact and compete across spatial scales. Phylogeographic methods have been used to characterize pathogen dispersal at global and regional scales but have yielded few insights into the local spatiotemporal structure of endemic transmission. Using geolocated genotype (800 cases) and serotype (17,291 cases) data, we show that in Bangkok, Thailand, 60% of dengue cases living <200 meters apart come from the same transmission chain, as opposed to 3% of cases separated by 1 to 5 kilometers. At distances <200 meters from a case (encompassing an average of 1300 people in Bangkok), the effective number of chains is 1.7. This number rises by a factor of 7 for each 10-fold increase in the population of the "enclosed" region. This trend is observed regardless of whether population density or area increases, though increases in density over 7000 people per square kilometer do not lead to additional chains. Within Thailand these chains quickly mix, and by the next dengue season viral lineages are no longer highly spatially structured within the country. In contrast, viral flow to neighboring countries is limited. These findings are consistent with local, density-dependent transmission and implicate densely populated communities as key sources of viral diversity, with home location the focal point of transmission. These findings have important implications for targeted vector control and active surveillance. C1 [Salje, Henrik; Lessler, Justin; Cummings, Derek A. T.] Johns Hopkins Bloomberg, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Salje, Henrik] Inst Pasteur, Math Modelling Infect Dis Unit, Paris, France. [Salje, Henrik] CNRS, URA3012, F-75015 Paris, France. [Salje, Henrik] Inst Pasteur, Ctr Bioinformat Biostat & Integrat Biol, F-75015 Paris, France. [Berry, Irina Maljkovic; Melendrez, Melanie C.; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. [Endy, Timothy] Upstate Med Univ New York, Dept Med, Syracuse, NY 13210 USA. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [A-Nuegoonpipat, Atchareeya; Chanama, Sumalee; Sangkijporn, Somchai; Sangarsang, Areerat] Natl Inst Hlth, Dept Med Sci, Nonthaburi, Thailand. [Klungthong, Chonticha; Thaisomboonsuk, Butsaya; Nisalak, Ananda; Gibbons, Robert V.; Macareo, Louis R.; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok, Thailand. [Iamsirithaworn, Sopon] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Yoon, In-Kyu] Int Vaccine Inst, Seoul, South Korea. [Cummings, Derek A. T.] Univ Florida, Dept Biol, Gainesville, FL 32610 USA. [Cummings, Derek A. T.] Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32610 USA. RP Salje, H; Lessler, J; Cummings, DAT (reprint author), Johns Hopkins Bloomberg, Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.; Salje, H (reprint author), Inst Pasteur, Math Modelling Infect Dis Unit, Paris, France.; Salje, H (reprint author), CNRS, URA3012, F-75015 Paris, France.; Salje, H (reprint author), Inst Pasteur, Ctr Bioinformat Biostat & Integrat Biol, F-75015 Paris, France.; Cummings, DAT (reprint author), Univ Florida, Dept Biol, Gainesville, FL 32610 USA.; Cummings, DAT (reprint author), Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32610 USA. EM henrik.salje@pasteur.fr; justin@jhu.edu; datc@ufl.edu OI Salje, Henrik/0000-0003-3626-4254 NR 32 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD MAR 24 PY 2017 VL 355 IS 6331 BP 1302 EP + DI 10.1126/science.aaj9384 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EP0NB UT WOS:000397082900037 PM 28336667 ER PT J AU Rice, NC Makar, JR Myers, TM AF Rice, Nathaniel C. Makar, Jennifer R. Myers, Todd M. TI Sex and the stimulus-movement effect: Differences in acquisition of autoshaped responding in cynomolgus monkeys SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE Classical conditioning; Sex difference; Response acquisition; Leaming; Stimulus movement; Monkey ID SPATIAL ABILITIES; MENSTRUAL-CYCLE; MACACA-MULATTA; RHESUS-MONKEYS; FEMALE RATS; PERFORMANCE; MEMORY; TASK; EXPLORATION; NEOPHOBIA AB The stimulus-movement effect refers to the phenomenon in which stimulus discrimination or acquisition of a response is facilitated by moving stimuli as opposed to stationary stimuli. The effect has been found in monkeys, rats, and humans, but the experiments conducted did not provide adequate female representation to investigate potential sex differences. The current experiment analyzed acquisition of stimulus touching in a progressive series of classical conditioning procedures in cynomolgus monkeys (Macaca fascicularis) as a function of sex and stimulus movement. Classical conditioning tasks arrange two or more stimuli in relation to each other with different temporal and predictive relations. Autoshaping procedures overlay operant contingencies onto a classical conditioning stimulus arrangement In the present case, a neutral stimulus (a small gray square displayed on a touchscreen) functioned as the conditional stimulus and a fodd pellet functioned as the unconditional stimulus. Although touching is not required to produce food, with repeated stimulus pairings subjects eventually touch the stimulus. Across conditions of increasing stimulus correlation and temporal contiguity, male monkeys acquired the response faster with a moving stimulus. In contrast, females acquired the response faster with a stationary stimulus. These results demonstrate that the stimulus-movement effect may be differentially affected by sex and indicate that additional experiments with females are needed to determine how sex interacts with behavioral phenomena discovered and elaborated almost exclusively using males. Published by Elsevier Inc. C1 [Rice, Nathaniel C.; Makar, Jennifer R.; Myers, Todd M.] US Army, Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. RP Myers, TM (reprint author), US Army, Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM Nathaniel.CRice3.ctr@mail.mil; Jennifer.R.Makar.ctr@mail.mil; Todd.M.Myers14.civ@mail.mil FU Defense Threat Reduction Agency, Medical ST Division [CB3945] FX This work was supported by the Defense Threat Reduction Agency (CB3945), Medical S&T Division. NR 59 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD MAR 15 PY 2017 VL 171 BP 40 EP 49 DI 10.1016/j.physbeh.2016.12.028 PG 10 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA EK6ZZ UT WOS:000394076100006 PM 28025092 ER PT J AU O'Brien, CP Dunbar, ZW Lee, IC AF O'Brien, Casey P. Dunbar, Zachary W. Lee, Ivan C. TI A spectroscopic membrane permeation cell for in-situ infrared-reflection absorption spectroscopic analysis of membrane surfaces and simultaneous measurement of trans-membrane gas permeation rates SO JOURNAL OF MEMBRANE SCIENCE LA English DT Article DE Spectroscopy; Membrane; Permeation; In-situ; Operando ID HYDROGEN PERMEATION; PALLADIUM MEMBRANE; CO ADSORPTION; CARBON-MONOXIDE; ELEVATED-TEMPERATURES; ULTRAHIGH-VACUUM; PD MEMBRANES; INHIBITION; H-2; PRESSURE AB In this work, we describe a spectroscopic membrane permeation cell that we have designed and fabricated to enable-for the first time-the surface of metal membranes to be analyzed by infrared-reflection absorption spectroscopy (IRAS) while simultaneously measuring the rate of hydrogen permeation across the membrane under realistic permeation conditions. As a proof-of-concept, we demonstrate that the permeation cell can (1) accurately measure the rate of H-2 permeation across a 25 pm-thick Pd foil membrane, (2) detect sub-monolayer coverages of CO on the membrane surface in the 333-533 K temperature range, and (3) measure the rate of H-2 permeation across the membrane while simultaneously detecting surface-adsorbed CO during exposure to H-2/ CO gas mixtures at 533 K. IRAS spectra recorded during exposure to H-2/CO gas mixtures at 533 K indicate that CO dissociates on the membrane surface, and C-H bonds are formed, which modify the surface adsorption properties of the membrane and result in irreversible losses in the H-2 flux across the membrane. With this spectroscopic membrane permeation cell, it is possible to correlate microscopic surface processes to macroscopic rates of permeation across the membrane, which will enable the rational design of hew membrane materials that are resistant to deactivation. C1 [O'Brien, Casey P.; Dunbar, Zachary W.; Lee, Ivan C.] US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Lee, IC (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ivan.c.lee2.civ@mail.mil FU U.S. Army Research Laboratory [W911NF-12-2-0019] FX Research was sponsored by the U.S. Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0019. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 38 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0376-7388 EI 1873-3123 J9 J MEMBRANE SCI JI J. Membr. Sci. PD MAR 15 PY 2017 VL 526 BP 43 EP 51 DI 10.1016/j.memsci.2016.12.016 PG 9 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA EK1YD UT WOS:000393722800006 ER PT J AU Satou, GM Rheuban, K Alverson, D Lewin, M Mahnke, C Marcin, J Martin, GR Mazur, LS Sahn, DJ Shah, S Tuckson, R Webb, CL Sable, CA AF Satou, Gary M. Rheuban, Karen Alverson, Dale Lewin, Mark Mahnke, Christopher Marcin, James Martin, Gerard R. Mazur, Lisa Schmitz Sahn, David J. Shah, Sanket Tuckson, Reed Webb, Catherine L. Sable, Craig A. CA Council Cardiovasc Dis Young Council Quality Care Outcomes Res TI Telemedicine in Pediatric Cardiology A Scientific Statement From the American Heart Association SO CIRCULATION LA English DT Article DE AHA Scientific Statements; cardiology; pediatrics; telemedicine ID INTENSIVE-CARE-UNIT; CARDIAC CRITICAL-CARE; LENGTH-OF-STAY; RURAL EMERGENCY-DEPARTMENTS; RANDOMIZED CONTROLLED-TRIAL; MIDDLE-INCOME COUNTRIES; TELE-ECHOCARDIOGRAPHY; PULSE OXIMETRY; TASK-FORCE; ATRIAL-FIBRILLATION AB Advancements in technology and broadband have revolutionized the current practice of medicine. The field of pediatric cardiology is no exception given the need for prompt diagnosis and reliance on cardiac imaging to identify infants and children with potentially life-threatening cardiovascular disease. As the relationship between telemedicine and pediatric cardiology has advanced, it has created a need to develop a broad, comprehensive document reviewing all the various aspects of telemedicine in pediatric cardiology. For more than a decade, a significant body of literature has been published describing individual experiences and practices, yet there remains no comprehensive statement or document summarizing this rapidly advancing field. In an effort to describe the collective experience and to provide structure and guidance for pediatric cardiology practitioners and healthcare providers, we have developed a scientific statement on the use of telemedicine in pediatric cardiology. Specific areas explored in this document include both neonatal and fetal teleechocardiography, implications for training community sonographers, pulse oximetry programs, qualitative improvement and appropriate use criteria initiatives, and remote electrophysiological monitoring. This document also includes teleconsultation and teleausculation, direct-to-consumer and home monitoring programs, and a look into the use of telemedicine and pediatric cardiology in the intensive care setting. Furthermore, a detailed review of the legislative, public policy, and legal aspects of telemedicine is provided, along with financial and reimbursement information. Several terms are used in the literature interchangeably; a brief explanation is provided to help readers of this document. The term telehealth is defined as the use of technology to bridge distances in any aspect of medicine; telemedicine is the specific application of technology to conduct clinical medicine at a distance. The term telecardiology is defined as the broad application of telemedicine in the field of cardiology specifically, and tele-echocardiography is the most common application used within this field. C1 [Satou, Gary M.] Univ Calif Los Angeles, Los Angeles, CA 90024 USA. [Martin, Gerard R.; Sable, Craig A.] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Alverson, Dale] Univ New Mexico, Albuquerque, NM 87131 USA. [Lewin, Mark] Childrens Hosp, 300 Longwood Ave, Boston, MA 02115 USA. [Mahnke, Christopher] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Marcin, James] Univ Calif Davis, Childrens Hosp, Davis, CA USA. [Mazur, Lisa Schmitz] McDermott Will & Emery LLP, Chicago, IL USA. [Rheuban, Karen] Univ Virginia, Charlottesville, VA 22903 USA. [Sahn, David J.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Shah, Sanket] Childrens Mercy Hosp, Kansas City, MO 64108 USA. [Webb, Catherine L.] Univ Michigan, Ann Arbor, MI 48109 USA. RP Satou, GM (reprint author), Univ Calif Los Angeles, Los Angeles, CA 90024 USA. NR 205 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD MAR 14 PY 2017 VL 135 IS 11 BP 648 EP 678 DI 10.1161/CIR.0000000000000478 PG 31 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA EN7XL UT WOS:000396215400001 PM 28193604 ER PT J AU Laurens, MB Kouriba, B Bergmann-Leitner, E Angov, E Coulibaly, D Diarra, I Daou, M Niangaly, A Blackwelder, WC Wu, YK Cohen, J Ballou, WR Vekemans, J Lanar, DE Dutta, S Diggs, C Soisson, L Heppner, DG Doumbo, OK Plowe, CV Thera, MA AF Laurens, Matthew B. Kouriba, Bourema Bergmann-Leitner, Elke Angov, Evelina Coulibaly, Drissa Diarra, Issa Daou, Modibo Niangaly, Amadou Blackwelder, William C. Wu, Yukun Cohen, Joe Ballou, W. Ripley Vekemans, Johan Lanar, David E. Dutta, Sheetij Diggs, Carter Soisson, Lorraine Heppner, D. Gray Doumbo, Ogobara K. Plowe, Christopher V. Thera, Mahamadou A. TI Strain-specific Plasmodium falciparum growth inhibition among Malian children immunized with a blood-stage malaria vaccine SO PLOS ONE LA English DT Article ID APICAL MEMBRANE ANTIGEN-1; GLUTAMATE-RICH PROTEIN; IN-VITRO; PARASITE GROWTH; CLINICAL MALARIA; ANTIBODIES; PROTECTION; TRIAL; CANDIDATE; MONOCYTES AB The blood-stage malaria vaccine FMP2.1/AS02A, comprised of recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1) and the adjuvant system AS02A, had strain-specific efficacy against clinical malaria caused by P. falciparum with the vaccine strain 3D7 AMA1 sequence. To evaluate a potential correlate of protection, we measured the ability of participant sera to inhibit growth of 3D7 and FVO strains in vitro using high-throughput growth inhibition assay (GIA) testing. Sera from 400 children randomized to receive either malaria vaccine or a control rabies vaccine were assessed at baseline and over two annual malaria transmission seasons after immunization. Baseline GIA against vaccine strain 3D7 and FVO strain was similar in both groups, but more children in the malaria vaccine group than in the control group had 3D7 and FVO GIA activity >= 15% 30 days after the last vaccination (day 90) (49% vs. 16%, p<0.0001; and 71.8% vs. 60.4%, p = 0.02). From baseline to day 90, 3D7 GIA in the vaccine group was 7.4 times the mean increase in the control group (p<0.0001). In AMA1 vaccinees, 3D7 GIA activity subsequently returned to baseline one year after vaccination (day 364) and did not correlate with efficacy in the extended efficacy time period to day 730. In Cox proportional hazards regression models with time-varying covariates, there was a slight suggestion of an association between 3D7 GIA activity and increased risk of clinical malaria between day 90 and day 240. We conclude that vaccination with this AMA1-based malaria vaccine increased inhibition of parasite growth, but this increase was not associated with allele-specific efficacy in the first malaria season. These results provide a framework for testing functional immune correlates of protection against clinical malaria in field trials, and will help to guide similar analyses for next-generation malaria vaccines. C1 [Laurens, Matthew B.; Blackwelder, William C.; Wu, Yukun; Plowe, Christopher V.] Univ Maryland, Sch Med, Inst Global Hlth, Div Malaria Res, Baltimore, MD 21201 USA. [Kouriba, Bourema; Coulibaly, Drissa; Diarra, Issa; Daou, Modibo; Niangaly, Amadou; Doumbo, Ogobara K.; Thera, Mahamadou A.] Malaria Res & Training Ctr, Bamako, Mali. [Bergmann-Leitner, Elke; Angov, Evelina; Lanar, David E.; Dutta, Sheetij; Heppner, D. Gray] Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Cohen, Joe; Ballou, W. Ripley; Vekemans, Johan] GSK Vaccines, Rixensart, Belgium. [Diggs, Carter; Soisson, Lorraine] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA. [Vekemans, Johan] World Hlth Org, Geneva, Switzerland. RP Laurens, MB (reprint author), Univ Maryland, Sch Med, Inst Global Hlth, Div Malaria Res, Baltimore, MD 21201 USA. EM mlaurens@medicine.umaryland.edu FU National Institute of Allergy and Infectious Diseases [N01AI85346, U19AI065683, HHSN272200800013C]; Fogarty International Center, National Institutes of Health [D43TW001589]; Department of Defense [W81XWH-06-1-0427]; U.S. Agency for International Development for site development and the conduct of the trial; U.S. Agency for International Development; Military Infectious Diseases Research Program, Fort Detrick, MD; Doris Duke Charitable Foundation Distinguished Clinical Scientist Award; Howard Hughes Medical Institute FX Supported by a contract (N01AI85346) and a cooperative agreement (U19AI065683) from the National Institute of Allergy and Infectious Diseases, a grant (D43TW001589) from the Fogarty International Center, National Institutes of Health, and a contract (W81XWH-06-1-0427) from the Department of Defense and the U.S. Agency for International Development for site development and the conduct of the trial; by a contract (HHSN272200800013C) from the National Institute of Allergy and Infectious Diseases for data management and statistical support; by grants from the U.S. Agency for International Development and the Military Infectious Diseases Research Program, Fort Detrick, MD, for vaccine production and laboratory assays; and by the Doris Duke Charitable Foundation Distinguished Clinical Scientist Award and an award from the Howard Hughes Medical Institute (to Dr. Plowe). The funder provided support in the form of salaries for authors [ML, DC, BK, ID, AN, WCB, OD, CP, MT], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 0 Z9 0 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 10 PY 2017 VL 12 IS 3 AR e0173294 DI 10.1371/journal.pone.0173294 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN6CJ UT WOS:000396091800027 PM 28282396 ER PT J AU Lu, S Mirchevska, G Phatak, SS Li, DM Luka, J Calderone, RA Fonzi, WA AF Lu, Sha Mirchevska, Gordana Phatak, Sayali S. Li, Dongmei Luka, Janos Calderone, Richard A. Fonzi, William A. TI Dynamic time warping assessment of high-resolution melt curves provides a robust metric for fungal identification SO PLOS ONE LA English DT Article ID POLYMERASE-CHAIN-REACTION; ACCURATE IDENTIFICATION; CANDIDA-DUBLINIENSIS; MEDICALLY IMPORTANT; TRANSCRIBED SPACER; DNA; REGION; PCR; COMPLEX; SPP. AB Fungal infections are a global problem imposing considerable disease burden. One of the unmet needs in addressing these infections is rapid, sensitive diagnostics. A promising molecular diagnostic approach is high-resolution melt analysis (HRM). However, there has been little effort in leveraging HRM data for automated, objective identification of fungal species. The purpose of these studies was to assess the utility of distance methods developed for comparison of time series data to classify HRM curves as a means of fungal species identification. Dynamic time warping (DTW), first introduced in the context of speech recognition to identify temporal distortion of similar sounds, is an elastic distance measure that has been successfully applied to a wide range of time series data. Comparison of HRM curves of the rDNA internal transcribed spacer (ITS) region from 51 strains of 18 fungal species using DTW distances allowed accurate classification and clustering of all 51 strains. The utility of DTW distances for species identification was demonstrated by matching HRM curves from 243 previously identified clinical isolates against a database of curves from standard reference strains. The results revealed a number of prior misclassifications, discriminated species that are not resolved by routine phenotypic tests, and accurately identified all 243 test strains. In addition to DTW, several other distance functions, Edit Distance on Real sequence (EDR) and Shape-based Distance (SBD), showed promise. It is concluded that DTW-based distances provide a useful metric for the automated identification of fungi based on HRM curves of the ITS region and that this provides the foundation for a robust and automatable method applicable to the clinical setting. C1 [Lu, Sha] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Dermatol, Guangzhou, Guangdong, Peoples R China. [Mirchevska, Gordana] Univ Sts Cyril & Methodius, Inst Microbiol & Parasitol, Skopje, Macedonia. [Phatak, Sayali S.; Li, Dongmei; Calderone, Richard A.; Fonzi, William A.] Georgetown Univ, Dept Microbiol & Immunol, Washington, DC 20057 USA. [Luka, Janos] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Fonzi, WA (reprint author), Georgetown Univ, Dept Microbiol & Immunol, Washington, DC 20057 USA. EM fonziw@georgetown.edu NR 60 TC 0 Z9 0 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 6 PY 2017 VL 12 IS 3 AR e0173320 DI 10.1371/journal.pone.0173320 PG 21 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN5OE UT WOS:000396054300052 ER PT J AU Smith, ER Mohr, MC Chader, SA AF Smith, Ernest R. Mohr, Michael C. Chader, Shanon A. TI Laboratory experiments on beach change due to nearshore mound placement SO COASTAL ENGINEERING LA English DT Article DE Nearshore-placed mounds; Longshore sediment transport; Dredged material; Surf zone processes; Physical modeling; Movable-bed modeling AB Movable-bed large-scale laboratory experiments were conducted to examine the fate and quantify the benefits of nearshore placed dredged material. Two tests were performed on a beach classified as eroding [19] for mounds placed in the active zone described by Hands and Allison [12] at two depths. Mound sand was dyed to provide contrast and to differentiate it from the native sand beach. Beach surveys were performed intermittently during each experiment with a laser scanner. In addition to beach change elevations, the scanner provided RGB color components, which permitted tracking of the mound sand. The experiments showed that the mound sand dispersed rapidly and was transported mainly downdrift. Sand accumulation was observed on the beach onshore and adjacent to the mounds mainly due to wave sheltering of the mounds described as the longshore effect by [28]. There was little contribution to onshore accretion from cross-shore migration of the mounds. Beach response was similar to that of an offshore breakwater in which the mounds provided a wave shadow zone to the leeward beach. The results from the experiment will provide validation data for the numerical morphological model C2SHORE [15]. C1 [Smith, Ernest R.] US Army, Engineer & Res Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Mohr, Michael C.; Chader, Shanon A.] US Army Engineer Dist, 1776 Niagara St, Buffalo, NY 14207 USA. RP Smith, ER (reprint author), US Army, Engineer & Res Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM ern.r.smith@gmail.com FU USACE District, Buffalo; USACE Regional Sediment Management Program; USACE Dredging Operations and Environmental Research Program FX This research was supported by the USACE District, Buffalo, the USACE Regional Sediment Management Program, and the USACE Dredging Operations and Environmental Research Program. The authors thank Drs. Jane McKee Smith, Julie D. Rosati, and Thomas Baldock for their insightful reviews. Permission to publish this paper was granted by the Headquarters, U.S. Army Corps of Engineers. NR 32 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 EI 1872-7379 J9 COAST ENG JI Coast. Eng. PD MAR PY 2017 VL 121 BP 119 EP 128 DI 10.1016/j.coastaleng.2016.12.010 PG 10 WC Engineering, Civil; Engineering, Ocean SC Engineering GA EL2UF UT WOS:000394475000010 ER PT J AU McDaniel, PB Sockalingam, S Deitzel, JM Gillespie, JW Keefe, M Bogetti, TA Casem, DT Weerasooriya, T AF McDaniel, Preston B. Sockalingam, Subramani Deitzel, Joseph M. Gillespie, John W., Jr. Keefe, Michael Bogetti, Travis A. Casem, Daniel T. Weerasooriya, Tusit TI The effect of fiber meso/nanostructure on the transverse compression response of ballistic fibers SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING LA English DT Article DE Polymer (textile) fibers; Nano-structures; Mechanical testing; Finite element analysis (FEA) ID MOLECULAR-WEIGHT POLYETHYLENE; HIGH-PERFORMANCE FIBERS; KM2 SINGLE-FIBER; POLY(P-PHENYLENE TEREPHTHALAMIDE) FIBERS; ATOMIC-FORCE MICROSCOPY; X-RAY-DIFFRACTION; ARAMID FIBERS; MECHANICAL-PROPERTIES; PLASTIC-DEFORMATION; COMPOSITE ARMOR AB The goal of this research is to understand the effect of fiber meso/nanostructure on the macroscopic quasi-static transverse compression response of ultra-high molecular weight polyethylene (UHMWPE) Dyneema SK76 fibers. These fibers exhibit nonlinear inelastic behavior with a small elastic limit and negligible elastic recovery upon unloading. Finite element model predictions of the experiment, using a continuum nonlinear inelastic constitutive description agree reasonably well with experimental force displacement, but under-predict the contact area. The apparent fiber cross-sectional area is found to increase up to a maximum of 1.83 times the original area at 46% nominal strain. SEM and AFM images of the meso/nanostructure of the compressed fibers indicate the apparent area growth is due to fibrillation. This fibrillation results in the deformation of a fibril network causing non-uniform fibril nesting and nucleation of new nanoscale voids between fibrils. A comparison of UHMWPE and Kevlar KM2 fiber transverse compressive response is also discussed.(C) 2016 Elsevier Ltd. All rights reserved. C1 [McDaniel, Preston B.; Sockalingam, Subramani; Deitzel, Joseph M.; Gillespie, John W., Jr.; Keefe, Michael] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [McDaniel, Preston B.; Gillespie, John W., Jr.; Keefe, Michael] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. [Sockalingam, Subramani; Gillespie, John W., Jr.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Bogetti, Travis A.; Casem, Daniel T.; Weerasooriya, Tusit] US Army Res Lab, Aberdeen, MD USA. RP McDaniel, PB (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM preston@udel.edu FU Army Research Laboratory [W911NF-12-2-022] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-022. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The authors PM and SS wish to acknowledge Mr. Michael Carroll of the University of Delaware, for his assistance with the transverse compression experiments. NR 48 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-835X EI 1878-5840 J9 COMPOS PART A-APPL S JI Compos. Pt. A-Appl. Sci. Manuf. PD MAR PY 2017 VL 94 BP 133 EP 145 DI 10.1016/j.compositesa.2016.12.003 PG 13 WC Engineering, Manufacturing; Materials Science, Composites SC Engineering; Materials Science GA EK8SA UT WOS:000394193300015 ER PT J AU Paliwal, B Hammi, Y Moser, RD Horstemeyer, MF AF Paliwal, B. Hammi, Y. Moser, R. D. Horstemeyer, M. F. TI A three-invariant cap-plasticity damage model for cementitious materials SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE Cement; Concrete; Cap-plasticity; Damage mechanics; Constitutive model; Multi-axial loading ID PLAIN CONCRETE; TRIAXIAL COMPRESSION; ANISOTROPIC DAMAGE; MICROPLANE MODEL; COUPLED ELASTOPLASTICITY; CONSTITUTIVE-EQUATIONS; FAILURE; FRACTURE; FORMULATION; MICROCRACKS AB We present a new continuum elastoplastic damage model for cementitious materials which captures their distinct behavior in tension and compression due to crack-induced damage and irreversible plastic deformation. It also describes their response under multi-axial loading with low to high confining pressures. A smooth, closed-convex three stress-invariant yield surface is developed which perpendicularly intersects the negative hydrostatic axis and is composed of a shear loading surface and an elliptical cap. It incorporates a plastic internal state variable (ISV) characterizing non-uniform hardening of both shear loading surface and elliptical cap, while the flow rule is considered to have volumetric non-associativity. Damage evolution laws incorporate two ISVs describing crack growth at the macroscale under tensile and compressive stresses separately. Overall damage under multiaxial loading explicitly considers the effect of confining stresses on damage evolution and stiffness recovery effects under cyclic loading. Model predictions are compared against several experimental results on various concretes and also against responses of recently reported models. The proposed model predicts distinctive features of concrete very well including hardening behavior in triaxial-compression and both pre- and post-peak volumetric behavior. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Paliwal, B.; Hammi, Y.; Horstemeyer, M. F.] Ctr Adv Vehicular Syst, 200 Res Blvd, Starkville, MS 39759 USA. [Paliwal, B.; Hammi, Y.; Horstemeyer, M. F.] Mississippi State Univ, Dept Mech Engn, Box 9552 Carpenter Bldg, Mississippi State, MS 39762 USA. [Moser, R. D.] US Army, Geotech & Struct Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Paliwal, B (reprint author), Ctr Adv Vehicular Syst, 200 Res Blvd, Starkville, MS 39759 USA.; Paliwal, B (reprint author), Mississippi State Univ, Dept Mech Engn, Box 9552 Carpenter Bldg, Mississippi State, MS 39762 USA. EM bp983@msstate.edu OI Horstemeyer, Mark/0000-0003-4230-0063 FU Center for Advanced Vehicular Systems (CAVS) at Mississippi State University; Engineering Research & Development Center [W912HZ-15-2-0004] FX This work was performed under the auspices of the Center for Advanced Vehicular Systems (CAVS) at Mississippi State University and sponsored by the Engineering Research & Development Center under Cooperative Agreement number W912HZ-15-2-0004. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the Engineering Research & Development Center or the U.S. Government. NR 55 TC 0 Z9 0 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 EI 1879-2146 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD MAR 1 PY 2017 VL 108 BP 186 EP 202 DI 10.1016/j.ijsolstr.2016.12.015 PG 17 WC Mechanics SC Mechanics GA EK7CA UT WOS:000394082000016 ER PT J AU Gu, ZQ Imbrenda, D Bennett-Jackson, AL Falmbigl, M Podpirka, A Parker, TC Shreiber, D Ivill, MP Fridkin, VM Spanier, JE AF Gu, Zongquan Imbrenda, Dominic Bennett-Jackson, Andrew L. Falmbigl, Matthias Podpirka, Adrian Parker, Thomas C. Shreiber, Daniel Ivill, Mathew P. Fridkin, Vladimir M. Spanier, Jonathan E. TI Mesoscopic Free Path of Nonthermalized Photogenerated Carriers in a Ferroelectric Insulator SO PHYSICAL REVIEW LETTERS LA English DT Article ID CARBON NANOTUBES; CRYSTALS; GRAPHENE; PHASE; GAS AB We show how finite-size scaling of a bulk photovoltaic effect-generated electric field in epitaxial ferroelectric insulating BaTiO3(001)films and a photo-Hall response involving the bulk photovoltaic current reveal a large room-temperature mean free path of photogenerated nonthermalized electrons. Experimental determination of mesoscopic ballistic optically generated carrier transport opens a new paradigm for hot electron-based solar energy conversion, and for facile control of ballistic transport distinct from existing low-dimensional semiconductor interfaces, surfaces, layers, or other structures. C1 [Gu, Zongquan; Imbrenda, Dominic; Spanier, Jonathan E.] Drexel Univ, Dept Elect & Comp Engn, Philadelphia, PA 19104 USA. [Bennett-Jackson, Andrew L.; Falmbigl, Matthias; Podpirka, Adrian; Spanier, Jonathan E.] Univ Penn, Dept Mat Sci & Engn, 3231 Walnut St, Philadelphia, PA 19104 USA. [Parker, Thomas C.; Shreiber, Daniel; Ivill, Mathew P.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Fridkin, Vladimir M.] Russian Acad Sci, Shubnikov Inst Crystallog, Leninsky Prospect 59, Moscow 117333, Russia. [Fridkin, Vladimir M.; Spanier, Jonathan E.] Drexel Univ, Dept Phys, Philadelphia, PA 19104 USA. RP Spanier, JE (reprint author), Univ Penn, Dept Mat Sci & Engn, 3231 Walnut St, Philadelphia, PA 19104 USA. EM spanier@drexel.edu FU U.S. Army Research Office [W911NF-14-1-0500]; National Science Foundation; Semiconductor Research Corporation under the Nanoelectronics and Beyond Program [DMR 1124696]; Office of Naval Research [N00014-1501102170]; SunShot Program of the U.S. Department of Energy [DE-SC0014664]; Army Research Laboratory FX This work was supported by the U.S. Army Research Office under Grant No. W911NF-14-1-0500. Z. G. was supported by the National Science Foundation and the Semiconductor Research Corporation under the Nanoelectronics in 2020 and Beyond Program under Grant No. DMR 1124696. M. F. was supported by the Office of Naval Research under Grant No. N00014-1501102170. A. P. was supported by the SunShot Program of the U.S. Department of Energy under Grant No. DE-SC0014664. The research was partially sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement No. W911NF-12-2-0019. The authors acknowledge the Drexel core shared facilities and NSF DMR 1040166. NR 32 TC 0 Z9 0 U1 0 U2 0 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 EI 1079-7114 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAR 1 PY 2017 VL 118 IS 9 AR 096601 DI 10.1103/PhysRevLett.118.096601 PG 5 WC Physics, Multidisciplinary SC Physics GA EN5KJ UT WOS:000396043900009 PM 28306282 ER PT J AU Mark, N Arthur, J Dontsova, K Brusseau, M Taylor, S Simunek, J AF Mark, Noah Arthur, Jennifer Dontsova, Katerina Brusseau, Mark Taylor, Susan Simunek, Jiri TI Column transport studies of 3-nitro-1,2,4-triazol-5-one (NTO) in soils SO CHEMOSPHERE LA English DT Article DE NTO; Insensitive munitions; Energetic materials; Natural attenuation; Transport ID INSENSITIVE MUNITIONS FORMULATIONS; CONTAMINANT TRANSPORT; DISSOLUTION; DEGRADATION; ADSORPTION; SORPTION; CLAY; FLOW AB Development of the new, insensitive, energetic compound, NTO (3-nitro-1,2,4-triazol-5-one), creates need for the data on NTO's fate and transport to predict its behavior in the environment and potential for groundwater contamination. To measure the transport of NTO in soils, we conducted miscible-displacement experiments under steady state and interrupted flow conditions using eight soils having varying physical and geochemical properties. The breakthrough curve (BTC) data were analyzed using temporal moment analysis and simulated using HYDRUS-1D to determine transport parameters and better understand the mechanisms of sorption and transformation. Parameters determined from the miscible-displacement study were compared to results obtained from batch experiments conducted for the same soils, and examined in relation to soil properties. Column NTO linear adsorption coefficients (K-d) were low and correlated well (P = 0.000049) with measurements from the batch studies. NTO transformation rate constants increased and NTO recovery decreased with increase in soil organic carbon (OC) content. Autoclaved soils had slower transformation rates and greater NTO recoveries indicating that microorganisms play a role in NTO transformation. In addition, the transformation rate increased with time in soils with higher OC. Monod-type kinetics was implemented in HYDRUS-1D to simulate the observed increase in transformation rate with time. We think this phenomenon is due to bacterial growth. Results indicate very low adsorption of NTO in a range of soils, but natural attenuation through transformation that, depending on soil OC content and hydraulic residence time, could result in complete removal of NTO. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Mark, Noah; Arthur, Jennifer; Dontsova, Katerina; Brusseau, Mark] Univ Arizona, Dept Soil Water & Environm Sci, 1177 E Fourth St,POB 210038,Shantz Bldg 38, Tucson, AZ 85721 USA. [Dontsova, Katerina] Univ Arizona, Biosphere 2, Marshall Bldg,Room 523,845 N Pk Ave, Tucson, AZ 85721 USA. [Taylor, Susan] US Army, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. [Simunek, Jiri] Univ Calif Riverside, Dept Environm Sci, Riverside, CA 92521 USA. RP Dontsova, K (reprint author), Univ Arizona, Biosphere 2, Marshall Bldg,Room 523,845 N Pk Ave, Tucson, AZ 85721 USA. EM dontsova@email.arizona.edu FU Strategic Environmental Research and Development Program (SERDP) [ER-2220] FX This work was funded by the Strategic Environmental Research and Development Program (SERDP), project ER-2220. We are grateful to Anthony Di Stasio and Erika Rivera, US Army Armament Research, Development and Engineering Center (ARDEC), Picatinny Arsenal for providing NTO; Bonnie M. Packer, Rosa Gwinn, Lisa DeGrazia, Bethany Keller, Jessica Milose, Amibeth Sheridan, Laurie Stenberg, Sarah Gettier, Army National Guard Environmental Directorate and URS Corporation, Germantown, MD and Mike Heitmann, CH2M HILL Englewood, CO for collecting soils used in the experiments on Army National Guard installations. NR 31 TC 0 Z9 0 U1 2 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD MAR PY 2017 VL 171 BP 427 EP 434 DI 10.1016/j.chemosphere.2016.12.067 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA EK4XL UT WOS:000393931100050 PM 28033573 ER PT J AU Allen, JB AF Allen, J. B. TI Monte Carlo simulations of polycrystalline ferroelectrics: Effects of electric field and grain size on dynamic electric polarization SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE Ferroelectrics; Monte Carlo; Simulation AB The present work incorporates a two dimensional Monte Carlo based polycrystalline simulation analysis for ferroelectric thin films. In the two stage process; first, grain growth is simulated via a traditional Q-State Monte Carlo method, taking into account isotropic grain boundary energies. Second, the grain growth results are incorporated within an electric polarization Model, combining contributions from a three component Hamiltonian, including the electrostatic potential, nearest neighbor electrical interactions, and electrostatic energy. Among other findings, the results suggest a strong correlation between electric polarization and grain size, particularly at relatively large electric field frequencies. Published by Elsevier B.V. C1 [Allen, J. B.] US Army, Engineer Res & Dev Ctr, Informat Technol Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Allen, JB (reprint author), US Army, Engineer Res & Dev Ctr, Informat Technol Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jeffrey.B.Allen@usace.army.mil NR 39 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 EI 1879-0801 J9 COMP MATER SCI JI Comput. Mater. Sci. PD MAR PY 2017 VL 129 BP 164 EP 170 DI 10.1016/j.commatsci.2016.12.022 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA EK6VV UT WOS:000394065000019 ER PT J AU Volner, K Dunn, B Chang, ET Song, SA Liu, SYC Brietzke, SE O'Connor, P Camacho, M AF Volner, Keith Dunn, Brandyn Chang, Edward T. Song, Sungjin A. Liu, Stanley Yung-Chuan Brietzke, Scott E. O'Connor, Peter Camacho, Macario TI Transpalatal advancement pharyngoplasty for obstructive sleep apnea: a systematic review and meta-analysis SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY LA English DT Review DE Obstructive sleep apnea; Transpalatal advancement pharyngoplasty; Sleep surgery; Systematic review; Meta-analysis ID COMPUTED TOMOGRAPHIC ANALYSIS; HARD PALATE; MAXILLOMANDIBULAR ADVANCEMENT; AIRWAY ANATOMY; APNEA/HYPOPNEA SYNDROME; VELOPHARYNGEAL SURGERY; FACIAL GROWTH; CLEFT-LIP; UVULOPALATOPHARYNGOPLASTY; PALATOPHARYNGOPLASTY AB The objective is to determine if apnea-hypopnea index (AHI) and lowest oxygen saturation (LSAT) improve after transpalatal advancement pharyngoplasty (TPAP) with obstructive sleep apnea (OSA) in adults, using a systematic review and meta-analysis. Nine databases, including PubMed/MEDLINE, were searched through April 1, 2016. All studies that included patients who underwent TPAP alone were included in this analysis. Fifty-six studies were potentially relevant, 37 were downloaded and five studies met criteria with 199 patients (age: 42.5 +/- 9.7 years and body mass index: 29.0 +/- 4.0 kg/m(2)). The grand mean (M) and standard deviation (SD) for AHI (199 patients) pre and post-TPAP decreased from 54.6 +/- 23.0 [95 % CI 51.4, 57.8] to 19.2 +/- 16.8 [95 % CI 16.9, 21.5] events/h (relative reduction: 64.8 %). Random effects modeling demonstrated a mean difference (MD) of -36.3 [95 % CI -48.5, -24.1], overall effect Z = 5.8 (p < 0.00001), and I (2) = 85 % (significant inconsistency). The standardized mean difference (SMD) for TPAP demonstrated a large magnitude of effect for AHI -1.76 [95 % CI -2.4, -1.1]. For LSAT (70 patients), the pre and post-TPAP M +/- SD improved from 81.9 +/- 8.1 [95 % CI 80.0, 83.8] to 85.4 +/- 6.9 [95 % CI 83.8, 87.0], with a MD of 3.55, overall effect Z = 1.79 (p = 0.07). Thus far, few studies have evaluated transpalatal advancement pharyngoplasty; therefore, we recommend additional studies, especially prospective studies. Research comparing TPAP to pharyngoplasty procedures without palatal advancement would help determine the optimal role for this procedure. C1 [Volner, Keith; Chang, Edward T.; Song, Sungjin A.] Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Dunn, Brandyn] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96813 USA. [Liu, Stanley Yung-Chuan] Stanford Univ, Div Sleep Surg, Dept Otolaryngol Head & Neck Surg, Sch Med, Stanford, CA 94305 USA. [Brietzke, Scott E.] Walter Reed Natl Mil Med Ctr, Dept Otolaryngol Head & Neck Surg, Bethesda, MD 20889 USA. [O'Connor, Peter] San Antonio Mil Med Ctr, Dept Otolaryngol Head & Neck Surg, Sleep Med, Joint Base San Antonio, Ft Sam Houston, TX 78234 USA. [Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. [Camacho, Macario] Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat & Behav Sci, Stanford, CA 95304 USA. RP Camacho, M (reprint author), Tripler Army Med Ctr, Div Sleep Surg & Med Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA.; Camacho, M (reprint author), Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat & Behav Sci, Stanford, CA 95304 USA. EM drcamachoent@yahoo.com NR 47 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0937-4477 EI 1434-4726 J9 EUR ARCH OTO-RHINO-L JI Eur. Arch. Oto-Rhino-Laryn. PD MAR PY 2017 VL 274 IS 3 BP 1197 EP 1203 DI 10.1007/s00405-016-4121-3 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA EL0ZR UT WOS:000394350800002 PM 27289234 ER PT J AU Ettisserry, DP Goldsman, N Lelis, AJ AF Ettisserry, Devanarayanan P. Goldsman, Neil Lelis, Aivars J. TI Role of Oxygen Vacancies in Short- and Long-Term Instability of Negative Bias-Temperature Stressed SiC MOSFETs SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE Density functional theory (DFT); oxygen vacancy; silicon carbide MOSFET; threshold voltage instability ID SWITCHING OXIDE TRAPS; TIME-DEPENDENCE; RELIABILITY; DEFECTS; CENTERS; DEVICES; MODEL AB We use hybrid-functional density functional theory to study the role of oxygen vacancies in negative bias-and-temperature stress-induced threshold voltage instability in 4H-silicon carbide power MOSFETs. According to our model, certain originally electrically "inactive" oxygen vacancies are structurally transformed into electrically "active" defects in the presence of strong negative bias and temperature. These newly generated defect configurations function as short-lived or long-lived switching oxide hole traps. The transients of their generation process are shown to correlate well with the measured "short-term" threshold voltage instability. Additionally, we show that the long-lived defects continueto degrade the room-temperature reliability of these devices even after stress removal. C1 [Ettisserry, Devanarayanan P.; Goldsman, Neil] Univ Maryland, Dept Elect Engn, College Pk, MD 20742 USA. [Ettisserry, Devanarayanan P.] Micron Technol Inc, Boise, ID 83707 USA. [Lelis, Aivars J.] US Army Res Lab, Adelphi, MD 20742 USA. RP Ettisserry, DP (reprint author), Univ Maryland, Dept Elect Engn, College Pk, MD 20742 USA.; Ettisserry, DP (reprint author), Micron Technol Inc, Boise, ID 83707 USA. EM dperinthatta@micron.com; neil@umd.edu; aivars.j.lelis.civ@mail.mil NR 40 TC 0 Z9 0 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 EI 1557-9646 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD MAR PY 2017 VL 64 IS 3 BP 1007 EP 1014 DI 10.1109/TED.2016.2647233 PG 8 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA EN5PA UT WOS:000396056700040 ER PT J AU Ogworonjo, HC Anderson, JMM Nguyen, LH AF Ogworonjo, Henry C. Anderson, John M. M. Nguyen, Lam H. TI An Iterative Parameter-Free MAP Algorithm With an Application to Forward Looking GPR Imaging SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Ground-penetrating radar (GPR); integrate-out; majorize-minimize; landmines; maximum a posteriori (MAP); parameter-free ID GROUND-PENETRATING RADAR; BAYESIAN REGULARIZATION; LANDMINE DETECTION; MIMO ARRAY; REGRESSION; SELECTION AB Ground-penetrating radar (GPR) has been used in a number of applications including the detection of land-mines and improvised explosive devices. Most existing algorithms for forward looking GPR image reconstruction require that a hyperparameter or regularization parameter be chosen by the user. Selecting these parameters in an optimal fashion is a challenging problem that, in theory, can be addressed using cross validation and the L-curve method. Unfortunately, these hyperparameter selection methods are time consuming and not well suited for real-time applications. In this paper, we propose a hyperparameter-free algorithm that follows from a maximum a posteriori (MAP) formulation where the prior probability density function is obtained by the so-called "integrate-out" approach. First, we model the reflection coefficients as statistically independent random variables that are identically distributed and Laplacian with parameter, lambda. Then, we analytically integrate out the parameter, lambda, and optimize the resulting MAP objective function using the majorize-minimize optimization technique and soft-thresholding operator. We tested the algorithm using synthetic and real experimental data, and compared the results subjectively and objectively with the results obtained from well-known algorithms. Although the evaluation is not an exhaustive study, it demonstrates the feasibility of the proposed algorithm. C1 [Ogworonjo, Henry C.; Anderson, John M. M.] Howard Univ, Dept Elect & Comp Engn, Washington, DC 20059 USA. [Nguyen, Lam H.] US Army Res Lab, Adelphi, MD 20783 USA. RP Ogworonjo, HC (reprint author), Howard Univ, Dept Elect & Comp Engn, Washington, DC 20059 USA. EM henryc582004@yahoo.com; j_m_anderson@howard.edu; lam.h.nguyen2.civ@mail.mil FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-1120039] FX This material is based upon work supported by, or in part by, the U.S. Army Research Laboratory and the U.S. Army Research Office under contract number W911NF-1120039. NR 47 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD MAR PY 2017 VL 55 IS 3 BP 1573 EP 1586 DI 10.1109/TGRS.2016.2627500 PG 14 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA EN6IC UT WOS:000396106700029 ER PT J AU Li, LY Tong, HH Cao, N Ehrlich, K Lin, YR Buchler, N AF Li, Liangyue Tong, Hanghang Cao, Nan Ehrlich, Kate Lin, Yu-Ru Buchler, Norbou TI Enhancing Team Composition in Professional Networks: Problem Definitions and Fast Solutions SO IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING LA English DT Article DE Graph kernel; scalability; team composition ID GRAPH KERNELS; SYSTEMS AB In this paper, we study ways to enhance the composition of teams based on new requirements in a collaborative environment. We focus on recommending team members who can maintain the team's performance by minimizing changes to the team's skills and social structure. Our recommendations are based on computing team-level similarity, which includes skill similarity, structural similarity as well as the synergy between the two. Current heuristic approaches are one-dimensional and not comprehensive, as they consider the two aspects independently. To formalize team-level similarity, we adopt the notion of graph kernel of attributed graphs to encompass the two aspects and their interaction. To tackle the computational challenges, we propose a family of fast algorithms by (a) designing effective pruning strategies, and (b) exploring the smoothness between the existing and the new team structures. Extensive empirical evaluations on real world datasets validate the effectiveness and efficiency of our algorithms. C1 [Li, Liangyue; Tong, Hanghang] Arizona State Univ, Sch Comp, Informat, Decis Syst Engn, Tempe, AZ 85281 USA. [Cao, Nan] Tongji Univ, 281 Fuxin Rd, Shanghai 200092, Peoples R China. [Ehrlich, Kate] IBM Res Cambridg, One Rogers St, Cambridge, MA 02142 USA. [Lin, Yu-Ru] Univ Pittsburgh, Sch Informat Sci, Pittsburgh, PA 15260 USA. [Buchler, Norbou] US Army, Res Lab, Adelphi, MD 20783 USA. RP Li, LY (reprint author), Arizona State Univ, Sch Comp, Informat, Decis Syst Engn, Tempe, AZ 85281 USA. EM liangyue@asu.edu; htong6@asu.edu; nan.cao@gmail.com; kate_enrlich@yahoo.com; yurulin@pitt.edu; norbou.buchler.civ@mail.mil OI Li, Liangyue/0000-0001-7630-8851 FU DTRA [HDTRA1-16-0017]; Army Research Office [W911NF-16-1-0168]; National Institutes of Health [R01LM011986]; Region II University Transportation Center [49997-33 25]; Baidu gift FX This work is supported by DTRA under the grant number HDTRA1-16-0017, by Army Research Office under the contract number W911NF-16-1-0168, by the National Institutes of Health under the grant number R01LM011986, Region II University Transportation Center under the project number 49997-33 25 and a Baidu gift. NR 48 TC 0 Z9 0 U1 1 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1041-4347 EI 1558-2191 J9 IEEE T KNOWL DATA EN JI IEEE Trans. Knowl. Data Eng. PD MAR 1 PY 2017 VL 29 IS 3 BP 613 EP 626 DI 10.1109/TKDE.2016.2633464 PG 14 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA EM8LX UT WOS:000395563900011 ER PT J AU Wang, YT Chen, IR Cho, JH Tsai, JJP AF Wang, Yating Chen, Ing-Ray Cho, Jin-Hee Tsai, Jeffrey J. P. TI Trust-Based Task Assignment With Multiobjective Optimization in Service-Oriented Ad Hoc Networks SO IEEE TRANSACTIONS ON NETWORK AND SERVICE MANAGEMENT LA English DT Article DE Trust management; multi-objective optimization; task assignment; service-oriented computing; mobile ad hoc networks; performance analysis ID WIRELESS SENSOR NETWORKS; DELAY-TOLERANT NETWORKS; INTRUSION DETECTION; ALLOCATION; MANAGEMENT; SYSTEMS; STRATEGY AB We propose and analyze a trust management protocol in service-oriented mobile ad hoc networks (MANETs) populated with service providers and service requesters, and demonstrate the resiliency and convergence properties against bad-mouthing, ballot-stuffing, opportunistic service, and self-promotion attacks. To demonstrate the applicability, we consider a mission-driven service-oriented MANET that must handle dynamically arriving tasks to achieve multiple conflicting objectives. We devise a trust-based heuristic algorithm based on auctioning with local knowledge of node status to solve this node-to-task assignment problem with multiobjective optimization (MOO) requirements. Our trust-based heuristic algorithm has a polynomial runtime complexity, rather than an exponential runtime complexity as in existing work, thus allowing dynamic node-to-task assignment to be performed at runtime. It outperforms a nontrust-based counterpart using blacklisting techniques while performing close to the ideal solution quality with perfect knowledge of node status over a wide range of environmental conditions. We conduct extensive sensitivity analysis of the results with respect to key design parameters and alternative trust protocol designs. We also develop a table-lookup method to apply the best trust protocol parameter settings upon detection of dynamically changing environmental conditions to maximize MOO performance. C1 [Wang, Yating; Chen, Ing-Ray] Virginia Tech, Dept Comp Sci, Falls Church, VA 22043 USA. [Cho, Jin-Hee] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. [Tsai, Jeffrey J. P.] Asia Univ, Dept Bioinformat & Biomed Engn, Taichung 41354, Taiwan. RP Wang, YT (reprint author), Virginia Tech, Dept Comp Sci, Falls Church, VA 22043 USA. EM yatingw@vt.edu; irchen@vt.edu; jinhee.cho@us.army.mil; jjptsai@gmail.com FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-12-1-0445]; Department of Defense (DoD) through the office of the Assistant Secretary of Defense for Research and Engineering (ASD (RE)) FX This work was supported in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under contract number W911NF-12-1-0445. This research was also partially supported by the Department of Defense (DoD) through the office of the Assistant Secretary of Defense for Research and Engineering (ASD (R&E)). The views and opinions of the authors do not reflect those of the DoD or ASD (R&E). The associate editor coordinating the review of this paper and approving it for publication was X. Fu. NR 33 TC 0 Z9 0 U1 3 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1932-4537 J9 IEEE T NETW SERV MAN JI IEEE Trans. Netw. Serv. Manag. PD MAR PY 2017 VL 14 IS 1 BP 217 EP 232 DI 10.1109/TNSM.2016.2636454 PG 16 WC Computer Science, Information Systems SC Computer Science GA EO0HN UT WOS:000396379000016 ER PT J AU Lu, DP Tao, JH Yan, PF Henderson, WA Li, QY Shao, YY Helm, ML Borodin, O Graff, GL Polzin, B Wang, CM Engelhard, M Zhang, JG De Yoreo, JJ Liu, J Xiao, J AF Lu, Dongping Tao, Jinhui Yan, Pengfei Henderson, Wesley A. Li, Qiuyan Shao, Yuyan Helm, Monte L. Borodin, Oleg Graff, Gordon L. Polzin, Bryant Wang, Chong-Min Engelhard, Mark Zhang, Ji-Guang De Yoreo, James J. Liu, Jun Xiao, Jie TI Formation of Reversible Solid Electrolyte Interface on Graphite Surface from Concentrated Electrolytes SO NANO LETTERS LA English DT Article DE Solid electrolyte interface; concentrated electrolyte; electrochemistry; Li-ion battery; graphite ID LI-ION BATTERIES; IN-SALT ELECTROLYTE; LITHIUM-ION; PROPYLENE CARBONATE; SUPERCONCENTRATED ELECTROLYTES; ELECTROCHEMICAL INTERCALATION; RECHARGEABLE BATTERIES; LIQUID ELECTROLYTES; NEGATIVE ELECTRODES; PERFORMANCE AB Li-ion batteries (LIB) have been successfully commercialized after the identification of ethylene-carbonate (EC)-containing electrolyte that can form a stable solid electrolyte interphase (SEI) on carbon anode surface to passivate further side reactions but still enable the transportation of the Li+ cation. These electrolytes are still utilized, with only minor changes, after three decades. However, the long-term cycling of LIB leads to continuous consumption of electrolyte and growth of SEI layer on the electrode surface, which limits the battery's life and performance. Herein, a new anode protection mechanism is reported in which, upon changing of the cell potential, the electrolyte components at the electrode-electrolyte interface reorganize reversibly to form a transient protective surface layers on the anode. This layer will disappear after the applied potential is removed so that no permanent SEI layer is required to protect the carbon anode. This phenomenon minimizes the need for a permanent SEI layer and prevents its continuous growth and therefore may lead to largely improved performance for LIBs. C1 [Lu, Dongping; Henderson, Wesley A.; Li, Qiuyan; Shao, Yuyan; Graff, Gordon L.; Zhang, Ji-Guang; Liu, Jun; Xiao, Jie] PNNL, Electrochem Mat & Syst Grp, Energy & Environm Directorate, Richland, WA 99352 USA. [Tao, Jinhui; Helm, Monte L.; De Yoreo, James J.] PNNL, Div Phys Sci, Fundamental & Computat Sci Directorate, Richland, WA 99352 USA. [Yan, Pengfei; Wang, Chong-Min; Engelhard, Mark] PNNL, EMSL, Richland, WA 99352 USA. [Borodin, Oleg] US Army Res Lab ARL, Sensor & Elect Devices Directorate, Electrochem Branch, Adelphi, MD 20783 USA. [Polzin, Bryant] Argonne Natl Lab, Chem Sci & Engn Div, Argonne, IL 60439 USA. [Xiao, Jie] Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA. RP Lu, DP; Xiao, J (reprint author), PNNL, Electrochem Mat & Syst Grp, Energy & Environm Directorate, Richland, WA 99352 USA. EM Dongping.lu@pnnl.gov; jiexiao@uark.edu RI Shao, Yuyan/A-9911-2008; yan, pengfei/E-4784-2016 OI Shao, Yuyan/0000-0001-5735-2670; yan, pengfei/0000-0001-6387-7502 FU Energy Efficiency and Renewable Energy (EERE) Office of Vehicle Technologies of the U.S. Department of Energy (DOE) [DEAC02-05CH11231, DEAC02-98CH10886]; DOE [DE-AC05-76RLO1830] FX This work was supported by the Energy Efficiency and Renewable Energy (EERE) Office of Vehicle Technologies of the U.S. Department of Energy (DOE) under contract nos. DEAC02-05CH11231 and DEAC02-98CH10886 for the Advanced Battery Materials Research (BMR) Program. The SEM, XPS, TEM, and STEM-EELS characterization was conducted in the William R. Wiley Environmental Molecular Sciences Laboratory (EMSL). PNNL is operated by Battelle for the DOE under contract no. DE-AC05-76RLO1830. NR 46 TC 0 Z9 0 U1 15 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD MAR PY 2017 VL 17 IS 3 BP 1602 EP 1609 DI 10.1021/acs.nanolett.6b04766 PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA EN7MB UT WOS:000396185800041 PM 28165750 ER PT J AU Rhodes, D Chenet, DA Janicek, BE Nyby, C Lin, Y Jin, W Edelberg, D Mannebach, E Finney, N Antony, A Schiros, T Klarr, T Mazzoni, A Chin, M Chiu, YC Zheng, W Zhang, QR Ernst, F Dadayp, JI Tong, X Ma, J Lou, R Wan, S Qian, T Ding, H Osgood, RM Paley, DW Lindenberg, AM Huang, PY Pasupathy, AN Dubey, M Hone, J Balicas, L AF Rhodes, D. Chenet, D. A. Janicek, B. E. Nyby, C. Lin, Y. Jin, W. Edelberg, D. Mannebach, E. Finney, N. Antony, A. Schiros, T. Klarr, T. Mazzoni, A. Chin, M. Chiu, Y. -c Zheng, W. Zhang, Q. R. Ernst, F. Dadayp, J. I. Tong, X. Ma, J. Lou, R. Wan, S. Qian, T. Ding, H. Osgood, R. M., Jr. Paley, D. W. Lindenberg, A. M. Huang, P. Y. Pasupathy, A. N. Dubey, M. Hone, J. Balicas, L. TI Engineering the Structural and Electronic Phases of MoTe2 through W Substitution SO NANO LETTERS LA English DT Article DE Transition-metal-dichalcogenides; phase-transformations; Weyl semimetals; electron microscopy; Raman spectroscopy; photoemission spectroscopy ID TRANSITION-METAL DICHALCOGENIDES; FEW-LAYER MOTE2; BAND-GAP; TRANSISTORS; MONOLAYER; SEMIMETAL; TEMPERATURE; INSULATOR; CONTACTS; BULK AB MoTe2 is an exfoliable transition metal dichalcogenide (TMD) that crystallizes in three symmetries: the semi-conducting trigonal-prismatic 2H- or alpha-phase, the semimetallic and monoclinic 1T'- or beta-phase, and the semimetallic orthorhombic gamma-structure. The 2H-phase displays a band gap of similar to 1 eV making it appealing for flexible and transparent optoelectronics. The gamma-phase is predicted to possess unique topological properties that might lead to topologically protected nondissipative transport channels. Recently, it was argued that it is possible to locally induce phase-transformations in TMDs, through chemical doping, local heating or electric-field to achieve ohmic contacts or to induce useful functionalities such as electronic phase-change memory elements. The combination of semiconducting and topological elements based upon the same compound might produce a new generation of high performance, low dissipation optoelectronic elements. Here, we show that it is possible to engineer the phases of MoTe2 through W substitution by unveiling the phase-diagram of the Mo1-xWxTe2 solid solution, which displays a semiconducting to semimetallic transition as a function of x. We find that a small critical W concentration x(c) similar to 8% stabilizes the gamma-phase at room temperature. This suggests that crystals with x close to x(c) might be particularly susceptible to phase transformations induced by an external perturbation, for example, an electric field. Photoemission spectroscopy, indicates that the gamma-phase possesses a Fermi surface akin to that of WTe2. C1 [Rhodes, D.; Chiu, Y. -c; Zheng, W.; Zhang, Q. R.; Balicas, L.] Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32310 USA. [Rhodes, D.; Chiu, Y. -c; Zheng, W.; Zhang, Q. R.] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA. [Chenet, D. A.; Hone, J.] Columbia Univ, Dept Mech Engn, New York, NY 10027 USA. [Janicek, B. E.] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA. [Nyby, C.] Stanford Univ, Dept Chem, Stanford, CA 94305 USA. [Lin, Y.; Jin, W.; Osgood, R. M., Jr.] Columbia Univ, Dept Appl Phys & Appl Math, New York, NY 10027 USA. [Edelberg, D.; Pasupathy, A. N.] Columbia Univ, Dept Phys, New York, NY 10027 USA. [Mannebach, E.; Lindenberg, A. M.] Stanford Univ, Dept Mat Sci & Engn, Stanford, CA 94305 USA. [Schiros, T.] Columbia Univ, Mat Res Sci & Engn Ctr, New York, NY 10027 USA. [Schiros, T.] SUNY Fash Inst Technol, Dept Sci & Math, New York, NY 10001 USA. [Klarr, T.; Mazzoni, A.; Chin, M.; Dubey, M.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20723 USA. [Ernst, F.] Stanford Univ, Dept Appl Phys, Stanford, CA 94305 USA. [Ernst, F.; Lindenberg, A. M.] SLAC Natl Accelerator Lab, Stanford PULSE Inst, Menlo Pk, CA 94025 USA. [Dadayp, J. I.; Osgood, R. M., Jr.] Columbia Univ, Dept Elect Engn, New York, NY 10027 USA. [Tong, X.] Brookhaven Natl Lab, Ctr Funct Nanomat, Upton, NY 11973 USA. [Ma, J.; Qian, T.; Ding, H.] Chinese Acad Sci, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China. [Ma, J.; Qian, T.; Ding, H.] Chinese Acad Sci, Inst Phys, Beijing 100190, Peoples R China. [Lou, R.; Wan, S.] Renmin Univ China, Dept Phys, Beijing 100872, Peoples R China. [Paley, D. W.] Columbia Univ, Dept Chem, New York, NY 10027 USA. [Paley, D. W.] Columbia Univ, Columbia Nano Initiat, New York, NY 10027 USA. [Lindenberg, A. M.] SLAC Natl Accelerator Lab, Stanford Inst Mat & Energy Sci, Menlo Pk, CA 94025 USA. [Huang, P. Y.] Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA. RP Balicas, L (reprint author), Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32310 USA. EM balicas@magnet.fsu.edu FU U.S. Army Research Office MURI [W911NF-11-1-0362]; Molecular and Electronic Nanostructures theme of the Beckman Institute at UIUC; U.S. Department of Energy, Basic Energy Sciences, Materials Sciences and Engineering Division; U.S. Department of Energy [DE-FG 02-04-ER-46157]; German National Academy of Sciences Leopoldina [LPDS 2013-13]; DOE-BES, Materials Sciences and Engineering Division [DEACO2-76SF00515]; W. M. Keck Foundation; Gordon and Betty Moore Foundation's EPiQS Initiative [GBMF4545]; AFOSR [FA9550-14-1-0268, FA955011-1-0010]; National Natural Science Foundation of China [11274381, 11474340, 11234014]; Ministry of Science and Technology of China [2015CB921300, 2013CB921700]; Chinese Academy of Sciences [XDB07000000]; NSF [DMR-1610110, NSF-DMR-1157490]; United States Department of Energy Office of Science [DE-SC0012704]; State of Florida; [DE-NA0002135] FX The subsequent order of authorship does not reflect the relative importance among the contributions from the different authors and groups. Their contributions to this work should be considered of equal relevance. L.B. is supported by the U.S. Army Research Office MURI Grant W911NF-11-1-0362. This work was supported in part by the Molecular and Electronic Nanostructures theme of the Beckman Institute at UIUC. Electron microscopy work was performed at the Frederick Seitz Materials Research Laboratory Central Research Facilities, University of Illinois. Single-crystal X-ray diffraction was performed in the Shared Materials Characterization Laboratory at Columbia University. A.M.L. acknowledges support by the U.S. Department of Energy, Basic Energy Sciences, Materials Sciences and Engineering Division. The work of RM.O., J.I.D., WJ, and Y.L. was financially supported by the U.S. Department of Energy under Contract No. DE-FG 02-04-ER-46157. F.E. gratefully acknowledges Grant LPDS 2013-13 from the German National Academy of Sciences Leopoldina. This work was also supported by the DOE-BES, Materials Sciences and Engineering Division under Contract DEACO2-76SF00515 and by the W. M. Keck Foundation and the Gordon and Betty Moore Foundation's EPiQS Initiative through Grant GBMF4545. D.C., N.F., AA., and J.H. acknowledge support from AFOSR grant FA9550-14-1-0268. N.F. acknowledges the Stewardship Science Graduate Fellowship program's support, provided under cooperative agreement number DE-NA0002135. R.L. and S.C.W. were supported by the National Natural Science Foundation of China (No. 11274381). J.Z.M., T.Q, and H.D. were supported by the Ministry of Science and Technology of China (Nos. 2015CB921300, 2013CB921700), the National Natural Science Foundation of China (Nos. 11474340, 11234014), and the Chinese Academy of Sciences (No. XDB07000000). STM work is supported by AFOSR (FA955011-1-0010, DE) and NSF (DMR-1610110, ANP). This research used resources of (XPS at) the Center for 'Functional Nanomaterials, which is a United States Department of Energy Office of Science Facility, at Brookhaven National Laboratory under Contract No. DE-SC0012704. The NHMFL is supported by NSF through NSF-DMR-1157490 and the State of Florida. NR 34 TC 0 Z9 0 U1 15 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1530-6984 EI 1530-6992 J9 NANO LETT JI Nano Lett. PD MAR PY 2017 VL 17 IS 3 BP 1616 EP 1622 DI 10.1021/acs.nanolett.6b04814 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA EN7MB UT WOS:000396185800043 PM 28145719 ER PT J AU Sava, E Clemente-Harding, L Cervone, G AF Sava, Elena Clemente-Harding, Laura Cervone, Guido TI Supervised classification of civil air patrol (CAP) SO NATURAL HAZARDS LA English DT Article DE Supervised classification; Remote sensing; Damage assessment; Natural hazards; Flood; Civil air patrol ID REMOTE-SENSING DATA; IMAGE CLASSIFICATION; GEOGRAPHIC INFORMATION; TEXTURE CLASSIFICATION; FLOOD EXTENT; LANDSAT TM; SEGMENTATION; DELINEATION; REGION AB The mitigation and response to floods rely on accurate and timely flood assessment. Remote sensing technologies have become the de facto approach for observing the Earth and its environment. However, satellite remote sensing data are not always available, and it is crucial to develop new techniques to complement them with additional sources. This research proposes a new methodology based on machine learning algorithms to automatically identify water pixels in Civil Air Patrol (CAP) aerial imagery. Specifically, a wavelet transformation is paired with multiple classifiers to build models that discriminate water and non-water pixels. The learned classification models are first tested against a set of control cases and then used to automatically classify each image separately. Lastly, for each pixel in an image, a measure of uncertainty is computed as a proportion of the number of models that classify the pixel as water. The proposed methodology is tested on imagery collected during the 2013 Colorado flood. C1 [Sava, Elena; Clemente-Harding, Laura; Cervone, Guido] Penn State Univ, Dept Geog, Geoinformat & Earth Observat Lab, State Coll, PA 16801 USA. [Sava, Elena; Clemente-Harding, Laura; Cervone, Guido] Penn State Univ, Inst CyberSci, State Coll, PA 16801 USA. [Clemente-Harding, Laura] Engineer Res & Dev Ctr, Geospatial Res Lab, Alexandria, VA USA. [Cervone, Guido] Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA. RP Sava, E (reprint author), Penn State Univ, Dept Geog, Geoinformat & Earth Observat Lab, State Coll, PA 16801 USA.; Sava, E (reprint author), Penn State Univ, Inst CyberSci, State Coll, PA 16801 USA. EM esava@psu.edu FU Office of Naval Research (ONR) [N00014-14-1-0208, 171570] FX Work performed under this project has been partially funded by the Office of Naval Research (ONR) Award #N00014-14-1-0208 (PSU #171570). We wish to thank Drs. Andris and Brooks for their comments that helped improve the present manuscript. NR 62 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0921-030X EI 1573-0840 J9 NAT HAZARDS JI Nat. Hazards PD MAR PY 2017 VL 86 IS 2 BP 535 EP 556 DI 10.1007/s11069-016-2704-3 PG 22 WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Geology; Meteorology & Atmospheric Sciences; Water Resources GA EL0RB UT WOS:000394328400003 ER PT J AU Huggan, M Mullen, GL Stevens, B Thomson, D AF Huggan, M. Mullen, G. L. Stevens, B. Thomson, D. TI Sudoku-like arrays, codes and orthogonality SO DESIGNS CODES AND CRYPTOGRAPHY LA English DT Article DE Elementary intervals; Hypercubes; Latin squares; MDS codes; Sudoku ID CLASSICAL ARCS; HYPERCUBES; PG(R,Q); SETS AB This paper is concerned with constructions and orthogonality of generalized Sudoku arrays of various forms. We characterize these arrays based on their constraints; for example Sudoku squares are characterized by having strip and sub-square constraints. First, we generalize Sudoku squares to be multi-dimensional arrays with strip and sub-cube constraints and construct mutually orthogonal sets of these arrays using linear polynomials. We add additional constraints motivated by elementary intervals for low discrepancy sequences and again give a construction of these arrays using linear polynomials in detail for 3 dimensional and a general construction method for arbitrary dimension. Then we give a different construction of these hypercubes due to MDS codes. We also analyze the orthogonality of all of the Sudoku-like hypercubes we consider in this paper. C1 [Huggan, M.] Dalhousie Univ, Dept Math & Stat, 6316 Coburg Rd,POB 15000, Halifax, NS B3H 4R2, Canada. [Mullen, G. L.] Penn State Univ, Dept Math, University Pk, PA 16802 USA. [Stevens, B.] Carleton Univ, Sch Math & Stat, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada. [Thomson, D.] US Mil Acad, Army Cyber Inst, Spellman Hall,2101 New South Post Rd, West Point, NY 10996 USA. [Thomson, D.] US Mil Acad, Dept Math Sci, Spellman Hall,2101 New South Post Rd, West Point, NY 10996 USA. RP Thomson, D (reprint author), US Mil Acad, Army Cyber Inst, Spellman Hall,2101 New South Post Rd, West Point, NY 10996 USA.; Thomson, D (reprint author), US Mil Acad, Dept Math Sci, Spellman Hall,2101 New South Post Rd, West Point, NY 10996 USA. EM Melissa.Huggan@dal.ca; mullen@math.psu.edu; brett@math.carleton.ca; dthomson@math.carleton.ca NR 18 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0925-1022 EI 1573-7586 J9 DESIGN CODE CRYPTOGR JI Designs Codes Cryptogr. PD MAR PY 2017 VL 82 IS 3 BP 675 EP 693 DI 10.1007/s10623-016-0190-y PG 19 WC Computer Science, Theory & Methods; Mathematics, Applied SC Computer Science; Mathematics GA EK2KX UT WOS:000393757300011 ER PT J AU Yeh, IC Lenhart, JL Rutledge, GC Andzelm, JW AF Yeh, In-Chul Lenhart, Joseph L. Rutledge, Gregory C. Andzelm, Jan W. TI Molecular Dynamics Simulation of the Effects of Layer Thickness and Chain Tilt on Tensile Deformation Mechanisms of Semicrystalline Polyethylene SO MACROMOLECULES LA English DT Article ID HIGH-DENSITY POLYETHYLENE; X-RAY-SCATTERING; PLASTIC-DEFORMATION; CRYSTALLINE POLYMERS; WEIGHT POLYETHYLENE; YIELD-STRESS; CAVITATION; TEMPERATURE; PHASE; PREDICTION AB We performed molecular dynamics simulations to investigate the effects of layer thicknesses of both crystalline and noncrystalline domains and chain tilt within the crystalline lamellae on tensile deformation mechanisms of the lamellar stack model of semicrystalline polyethylene. For equal thicknesses of crystalline and noncrystalline regions, similar stress-strain profiles were obtained with two different initial orientations of the crystal stem relative to the tensile direction. Repeated melting/recrystallization transitions were observed, at the slower strain rate of 5 X 10(6)s(-1), characterized by oscillating stress strain profiles. With increasing thickness of the crystalline regions, these oscillations occurred less frequently. For systems with initially tilted chain stems in the crystalline domain, decreasing the thickness of the noncrystalline region increased the number of short bridge segments in the noncrystalline region connecting the two crystalline regions and induced significant shear stresses, rearrangements in the crystalline region, and the strain hardening during the tensile deformation. C1 [Yeh, In-Chul; Lenhart, Joseph L.; Andzelm, Jan W.] US Army, Macromol Sci & Technol Branch, Mat & Mfg Sci Div, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Rutledge, Gregory C.] MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA. RP Yeh, IC; Andzelm, JW (reprint author), US Army, Macromol Sci & Technol Branch, Mat & Mfg Sci Div, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM in-chul.yeh.ctr@mail.mil; jan.w.andzelm.civ@mail.mil FU Postgraduate Research Participation Program at the U.S. Army Research Laboratory (ARL) FX This work was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory (ARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ARL. The DoD HPC Modernization Office supported this project by supplying supercomputer time. We thank Drs. Kevin Masser and Timothy Sirk for helpful discussions and comments. NR 44 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 EI 1520-5835 J9 MACROMOLECULES JI Macromolecules PD FEB 28 PY 2017 VL 50 IS 4 BP 1700 EP 1712 DI 10.1021/acs.macromol.6b01748 PG 13 WC Polymer Science SC Polymer Science GA EM5NO UT WOS:000395358500042 ER PT J AU Kelly, FR Hull, RA Arrey-Mbi, TB Williams, MU Lee, JS Slim, AM Thomas, DM AF Kelly, Faith R. Hull, Robert A. Arrey-Mbi, Takor B. Williams, Michael U. Lee, Joshua S. Slim, Ahmad M. Thomas, Dustin M. TI Left atrial appendage morphology and risk of stroke following pulmonary vein isolation for drug-refractory atrial fibrillation in low CHA(2)DS(2)Vasc risk patients SO BMC CARDIOVASCULAR DISORDERS LA English DT Article DE Left atrial appendage; Stroke; CVA; Pulmonary vein isolation; PVI; Atrial fibrillation; CHA2DS2Vasc; Cardiac CT Angiography; CCT ID CARDIAC CT ANGIOGRAPHY; CATHETER ABLATION; RADIOFREQUENCY ABLATION; ANTIARRHYTHMIC-DRUGS; THROMBOEMBOLIC RISK; COMPUTED-TOMOGRAPHY; 1ST-LINE TREATMENT; RANDOMIZED-TRIAL; THROMBUS; INTEGRATION AB Background: Cardiac CT angiography (CCTA) has become an important adjunct in the structural assessment of the pulmonary veins (PV) prior to pulmonary vein isolation (PVI). Published data is conflicting regarding a relationship between left atrial appendage (LAA) and the risk of ischemic stroke (CVA) following PVI. We investigated the associations of volumetric and morphologic left atrial (LA) and LAA measurements for CVA following PVI. Methods: We retrospectively reviewed 332 consecutive patients with drug refractory atrial fibrillation who obtained cardiac CT angiogram (CCTA) prior to PVI. Baseline demographic data, procedural and lab details, and outcomes were obtained from abstraction of an electronic medical records system. LA, LAA, and PV volumes were measured using CCTA datasets utilizing a semi-automated 3D workstation application. LAA morphology was assigned utilizing volume rendered images as previously described. Results: The study cohort was 55 +/- 13 years-old, 83.7% male, low CVA risk (median CHA(2)DS(2)Vasc 1; IQR 1, 3), and 30.4% were treated with novel oral anticoagulants. Chicken wing (CW) was the most common morphology (52%), followed by windsock (WS), cauliflower (CF), and cactus (CS) at 18, 9, and 2%, respectively. CVAs occurred in 4 patients following PVI with median time to CVA of 170.5 days. All CVAs were observed in CW morphology patients. When comparing CW morphology with non-CW morphology, CVAs occurred more frequently with the CW morphology (2.1% vs 0%, p = 0.03). This difference was not significant, though, after adjusting for CHA(2)DS(2)Vasc risk factors (p = 0.14). Conclusion: The CW morphology was observed more commonly in patients who experienced post-PVI CVA. After adjusting for CHA(2)DS(2)Vasc risk factors, CW morphology was not an independent predictor of post-PVI CVA. These findings should be interpreted in the setting of a low CVA event rate amongst a low risk population that was highly compliant with indicated anticoagulation therapy. C1 [Kelly, Faith R.; Lee, Joshua S.; Slim, Ahmad M.; Thomas, Dustin M.] Brooke Army Med Ctr, Dept Cardiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. [Hull, Robert A.; Arrey-Mbi, Takor B.; Williams, Michael U.] Brooke Army Med Ctr, Dept Med, San Antonio, TX USA. RP Thomas, DM (reprint author), Brooke Army Med Ctr, Dept Cardiol, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. EM dustin.m.thomas4.mil@mail.mil NR 22 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2261 J9 BMC CARDIOVASC DISOR JI BMC Cardiovasc. Disord. PD FEB 28 PY 2017 VL 17 AR 70 DI 10.1186/s12872-017-0504-7 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EM7DD UT WOS:000395470800001 PM 28245798 ER PT J AU Cooper, N Bassett, DS Falk, EB AF Cooper, Nicole Bassett, Danielle S. Falk, Emily B. TI Coherent activity between brain regions that code for value is linked to the malleability of human behavior SO SCIENTIFIC REPORTS LA English DT Article ID MEDIAL PREFRONTAL CORTEX; PHYSICAL-ACTIVITY; FUNCTIONAL CONNECTIVITY; SOCIAL-INFLUENCE; PSYCHOPHYSIOLOGICAL INTERACTIONS; NEURAL RESPONSES; VENTRAL STRIATUM; DEFAULT NETWORK; HEALTH MESSAGES; SELF AB Brain activity in medial prefrontal cortex (MPFC) during exposure to persuasive messages can predict health behavior change. This brain-behavior relationship has been linked to areas of MPFC previously associated with self-related processing; however, the mechanism underlying this relationship is unclear. We explore two components of self-related processing-self-reflection and subjective valuation- and examine coherent activity between relevant networks of brain regions during exposure to health messages encouraging exercise and discouraging sedentary behaviors. We find that objectively logged reductions in sedentary behavior in the following month are linked to functional connectivity within brain regions associated with positive valuation, but not within regions associated with self-reflection on personality traits. Furthermore, functional connectivity between valuation regions contributes additional information compared to average brain activation within single brain regions. These data support an account in which MPFC integrates the value of messages to the self during persuasive health messaging and speak to broader questions of how humans make decisions about how to behave. C1 [Cooper, Nicole; Falk, Emily B.] Univ Penn, Annenberg Sch Commun, Philadelphia, PA 19104 USA. [Cooper, Nicole] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Bassett, Danielle S.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA. [Bassett, Danielle S.] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA. RP Cooper, N; Falk, EB (reprint author), Univ Penn, Annenberg Sch Commun, Philadelphia, PA 19104 USA.; Cooper, N (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM ncooper@asc.upenn.edu; falk@asc.upenn.edu FU Michigan Center of Excellence in Cancer Communications Research; Michigan Center of Excellence in Cancer Communication Research/NIH [P50 CA101451]; NIH New Innovator Award [1 DP2 DA035156-01]; NIH/National Cancer Institute Grant [1R01CA180015-01]; NIH/National Cancer Institute; FDA Center for Tobacco [P50CA179546]; ARL Cooperative Agreement [W911NF-10-2-0022, APX02-0006]; John D. and Catherine T. MacArthur Foundation; Alfred P. Sloan Foundation FX We thank Holly Derry, Ian Moore, and Michele Demers for assistance in developing intervention materials, and the staff of the University of Michigan fMRI Center for support and assistance with fMRI data acquisition. We thank Angela Fagerlin, Thad Polk, and the Michigan Center of Excellence in Cancer Communications Research for support in realizing this project, and Sonya Dal Cin and Sara Konrath for helpful discussions. We thank Frank Tinney, Kristin Shumaker, Matthew Brook O'Donnell, Christopher Casio, Nicolette Gregor, and Alison Sagon for assistance with data collection and Jonathan Mitchell for advice regarding processing of the accelerometer data. This research was supported by The Michigan Center of Excellence in Cancer Communication Research/NIH Grant P50 CA101451 [to principal investigator (PI), V.J.S.], NIH New Innovator Award 1 DP2 DA035156-01 (to PI, E.B.F.), NIH/National Cancer Institute Grant 1R01CA180015-01 (to PI, E.B.F.), and NIH/National Cancer Institute and FDA Center for Tobacco Products Grant P50CA179546 (to PIs, E.B.F., D.S.B., N.C.) and ARL Cooperative Agreement Number W911NF-10-2-0022, Subcontract Number APX02-0006. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the Food and Drug Administration (FDA). D.S.B. also acknowledges support from the John D. and Catherine T. MacArthur Foundation and from the Alfred P. Sloan Foundation. NR 73 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD FEB 27 PY 2017 VL 7 AR 43250 DI 10.1038/srep43250 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL9SX UT WOS:000394961500001 PM 28240271 ER PT J AU Lamanna, E Gupta, N Cappa, P Strbik, OM Cho, K AF Lamanna, Emanuele Gupta, Nikhil Cappa, Paolo Strbik, Oliver M., III Cho, Kyu TI Evaluation of the dynamic properties of an aluminum syntactic foam core sandwich SO JOURNAL OF ALLOYS AND COMPOUNDS LA English DT Article DE Metal matrix composite; Metal matrix syntactic foam; Hollow particles; Vibration; Dynamic property ID MECHANICAL-PROPERTIES; COMPOSITE-MATERIALS; VIBRATION RESPONSE; DAMPING ANALYSIS; COMPLEX MODULUS; VOLUME FRACTION; BEAMS; GLASS; IDENTIFICATION; PERFORMANCE AB The purpose of this study is to evaluate the dynamic mechanical properties of syntactic foam core sandwich structures. Aluminum matrix syntactic foams with carbon fabric skins are studied. Syntactic foams incorporate porosity in their foam-like structure by means of hollow particles. The material examined here is composed of a core made of aluminum A356 matrix filled with alumina hollow particles. Two types of sandwich composites are studied containing: (a) a single layer of carbon fabric and (b) three layers of the same fabric in 0 degrees/90 degrees orientation. Dynamic characterization was conducted using a free vibration method to determine the resonant frequency of the sandwich beams. The dynamic modulus, storage modulus, loss modulus and damping ratio were calculated from the test results. The experimental results were used to validate the predictions of a theoretical model. The experimental values for Young's modulus of one-and three-layer fabric sandwiches were measured to be 32.57 +/- 2.15 and 37.33 +/- 1.12 GPa, respectively. The experimental results are in close agreement with the theoretical model. (C) 2016 Elsevier B.V. All rights reserved. C1 [Lamanna, Emanuele; Gupta, Nikhil] NYU, Composite Mat & Mech Lab, Dept Mech & Aerosp Engn, Tandon Sch Engn, 6 MetroTech Ctr, Brooklyn, NY 11201 USA. [Cappa, Paolo] Sapienza Univ Rome, Dept Mech & Aerosp Engn, Via Eudossiana 18, I-00184 Rome, Italy. [Strbik, Oliver M., III] Deep Springs Technol Inc, Toledo, OH 43615 USA. [Cho, Kyu] Weap & Mat Res Directorate, US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gupta, N (reprint author), NYU, Composite Mat & Mech Lab, Dept Mech & Aerosp Engn, Tandon Sch Engn, 6 MetroTech Ctr, Brooklyn, NY 11201 USA. EM ngupta@nyu.edu OI gupta, nikhil/0000-0001-7128-4459 FU U.S. Army Research Laboratory, NYU [W911NF-11-2-0096]; U.S. Army Research Laboratory, DST [W911NF-10-2-0084]; NSF [IIA-445686] FX This research is sponsored by the U.S. Army Research Laboratory Cooperative Agreement W911NF-11-2-0096 with NYU and the contract W911NF-10-2-0084 with DST. Partial support from NSF grant IIA-445686 is also acknowledged. Eduardo Palermo, Fausto Del Sette and Federico R. Conticello from "Sapienza" University of Rome are thanked for providing important laboratory instruments and for help during the research work. Steven Eric Zeltmann is thanked for assistance in manuscript preparation. NR 42 TC 0 Z9 0 U1 24 U2 24 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-8388 EI 1873-4669 J9 J ALLOY COMPD JI J. Alloy. Compd. PD FEB 25 PY 2017 VL 695 BP 2987 EP 2994 DI 10.1016/j.jallcom.2016.11.361 PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA EH5MV UT WOS:000391818100005 ER PT J AU Shen, J Chen, X Hammond, V Kecskes, LJ Mathaudhu, SN Kondoh, K Wei, Q AF Shen, J. Chen, X. Hammond, V. Kecskes, L. J. Mathaudhu, S. N. Kondoh, K. Wei, Q. TI The effect of rolling on the microstructure and compression behavior of AA5083 subjected to large-scale ECAE SO JOURNAL OF ALLOYS AND COMPOUNDS LA English DT Article DE Al alloy; Equal channel angular extrusion (ECAE); Rolling; Mechanical properties ID HIGH-PRESSURE TORSION; SEVERE PLASTIC-DEFORMATION; CHANNEL ANGULAR EXTRUSION; GRAIN-REFINEMENT; MECHANICAL-PROPERTIES; ALUMINUM-ALLOY; METALS; AL; EVOLUTION; MAGNESIUM AB In the present work, an aluminum alloy AA5083 that went through equal channel angular extrusion (ECAE) was further processed with rolling under two different conditions. Mechanical examination on both as-ECAE and ECAE + Rolling samples suggests that such post-ECAE processes can further effectively enhance the strength of the alloy. The underlying mechanisms were investigated with the assistance of microstructural examination using transmission electron microscopy (TEM). Precipitates of two mor-phologies were found in the alloys with dimensions ranging from a few to hundreds of nanometers. These precipitates were determined to have a minor effect on the strength differences between the alloys with or without post-ECAE rolling. However, the work hardening caused by the high number of dislocations accumulated inside the grains and the concomitant grain size reduction along the normal direction (ND) due to plate thickness reduction were considered as the primary reasons for the strength increase in the post-ECAE rolled AA5083. (C) 2016 Elsevier B.V. All rights reserved. C1 [Shen, J.; Chen, X.; Wei, Q.] Univ North Carolina Charlotte, Dept Mech Engn, Charlotte, NC 28223 USA. [Shen, J.] Northwestern Polytech Univ, Sch Aeronaut, Xian 710072, Peoples R China. [Shen, J.; Kondoh, K.] Osaka Univ, Joining & Welding Res Inst, 11-1 Mihogaoka, Osaka 5670047, Japan. [Hammond, V.; Kecskes, L. J.] US Army Res Lab, WMRD, 4600 Deer Creek Loop, Aberdeen, MD 21005 USA. [Mathaudhu, S. N.] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA. RP Wei, Q (reprint author), Univ North Carolina Charlotte, Dept Mech Engn, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Shen, Jianghua/C-2586-2013 OI Shen, Jianghua/0000-0003-1017-0698 FU U.S. Army Research Laboratory [W911NF-14-0061]; 111 project [B07050] FX This work is supported by the U.S. Army Research Laboratory under Contract No. W911NF-14-0061. The authors sincerely appreciate the technical support from Mr. Murakami; J. Shen would also like to thank China Scholarship Council and the 111 project (No. B07050). NR 39 TC 0 Z9 0 U1 7 U2 7 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-8388 EI 1873-4669 J9 J ALLOY COMPD JI J. Alloy. Compd. PD FEB 25 PY 2017 VL 695 BP 3589 EP 3597 DI 10.1016/j.jallcom.2016.11.406 PG 9 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA EH5MV UT WOS:000391818100081 ER PT J AU Huang, YD Zhang, L Janes, H Frahm, N Isaacs, A Kim, JH Montefiori, D McElrath, MJ Tomaras, GD Gilbert, PB AF Huang, Yunda Zhang, Lily Janes, Holly Frahm, Nicole Isaacs, Abby Kim, Jerome H. Montefiori, David McElrath, M. Julie Tomaras, Georgia D. Gilbert, Peter B. TI Predictors of durable immune responses six months after the last vaccination in preventive HIV vaccine trials SO VACCINE LA English DT Article DE Binding antibody multiplex array; Immunogenicity; Intracellular cytokine staining; Regularised random forest; Statistical power ID HEPATITIS-A VACCINE; LONG-TERM PERSISTENCE; ANTIBODY PERSISTENCE; CLINICAL-TRIALS; EFFICACY TRIAL; VIRUS; IMMUNOGENICITY; MEMORY; OPTIMIZATION; EFFICIENT AB Background: The evaluation of durable immune responses is important in HIV vaccine research and development. The efficiency of such evaluation could be increased by incorporating predictors of the responses in the statistical analysis. In this paper, we investigated whether and how baseline demographic variables and immune responses measured two weeks after vaccination predicted durable immune responses measured six months later. Methods: We included data from seven preventive HIV vaccine regimens evaluated in three clinical trials: a Phase 1 study of four DNA, NYVAC and/or AIDSVAX vaccine regimens (HVTN096), a Phase 2 study of two DNA and/or MVA vaccine regimens (HVTN205), and a Phase 3 study of a single ALVAC/AIDSVAX regimen (RV144). Regularized random forests and linear regression models were used to identify and evaluate predictors of the positivity and magnitude of durable immune responses. Results: We analyzed 201 vaccine recipients with data from 10 to 127 immune response biomarkers, and 3-5 demographic variables. The best prediction of participants' durable response positivity based on two-week responses rendered up to close-to-perfect accuracy; the best prediction of participants' durable response magnitude rendered correlation coefficients between the observed and predicted responses ranging up to 0.91. Though prediction performances differed among biomarkers, durable immune responses were best predicted by the two-week response level of the same biomarker. Adding demographic information and two-week response levels of different biomarkers provided little or no improvement in the predictions. Conclusions: For some biomarkers and for the vaccines we studied, two-week post-vaccination responses can well predict durable responses six months later. Therefore, if immune response durability is only assessed in a sub-sample of vaccine recipients, statistical analyses of durable responses will have increased efficiency by incorporating two-week response data. Further research is needed to generalize the findings to other vaccine regimens and biomarkers. (C) 2017 Elsevier Ltd. All rights reserved. C1 [Huang, Yunda; Zhang, Lily; Janes, Holly; Frahm, Nicole; Isaacs, Abby; McElrath, M. Julie; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1100 Fairview Ave N, Seattle, WA 98109 USA. [Huang, Yunda; Zhang, Lily; Janes, Holly; Isaacs, Abby; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA. [Huang, Yunda; Frahm, Nicole; McElrath, M. Julie] Univ Washington, Dept Global Hlth, 1510 San Juan Rd, Seattle, WA 98195 USA. [Janes, Holly; Gilbert, Peter B.] Univ Washington, Dept Biostat, 1705 NE Pacific St, Seattle, WA 98195 USA. [Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Kim, Jerome H.] Int Vaccine Inst, 1 Gwanak Ro, Seoul, South Korea. [Montefiori, David; Tomaras, Georgia D.] Duke Human Vaccine Inst, Genome Court, MSRB 2, Durham, NC 27710 USA. [McElrath, M. Julie] Univ Washington, Dept Lab Med, 1959 NE Pacific St, Seattle, WA 98195 USA. [McElrath, M. Julie] Univ Washington, Dept Med, 1959 NE Pacific St, Seattle, WA 98195 USA. RP Huang, YD (reprint author), Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1100 Fairview Ave N, Seattle, WA 98109 USA. EM yunda@scharp.org; yzhang2@scharp.org; hjanes@fredhutch.org; nfrahm@fredhutch.org; aisaacs@scharp.org; Jerome.Kim@ivi.int; david.montefiori@duke.edu; jmcelrat@fredhutch.org; gdt@duke.edu; pgilbert@scharp.org FU National Institutes of Health [UM1 AI068635, UM1 AI068614, UM1 AI068618]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DoD) [W81XWH-11-2-0174]; Henry Jackson Foundation for the Military HIV Research Program [792087] FX This work was supported by the National Institutes of Health [UM1 AI068635, UM1 AI068614, and UM1 AI068618]. The RV144 study was supported by a cooperative agreement [W81XWH-11-2-0174] between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the U.S. Department of Defense (DoD). The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Army or the DoD. This work was partially supported by contract # 792087 from the Henry Jackson Foundation for the Military HIV Research Program. NR 34 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD FEB 22 PY 2017 VL 35 IS 8 BP 1184 EP 1193 DI 10.1016/j.vaccine.2016.09.053 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA EL2UP UT WOS:000394476000015 PM 28131393 ER PT J AU Barouch, DH Thomas, SJ Michael, NL AF Barouch, Dan H. Thomas, Stephen J. Michael, Nelson L. TI Prospects for a Zika Virus Vaccine SO IMMUNITY LA English DT Review ID ANTIBODY-DEPENDENT ENHANCEMENT; BORNE ENCEPHALITIS-VIRUS; DENGUE HEMORRHAGIC-FEVER; GUILLAIN-BARRE-SYNDROME; JAPANESE ENCEPHALITIS; PROTECTIVE EFFICACY; CROSS-REACTIVITY; DISEASE SEVERITY; STRUCTURAL BASIS; BIRTH-DEFECTS AB A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated with microcephaly and other congenital malformations in infants as well as Guillain-Barre syndrome in adults. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Promising data from preclinical vaccine studies in mice and monkeys suggest that an effective vaccine will likely be possible, but important scientific challenges remain. Here we review the current state of ZIKV vaccine development. We discuss different vaccination strategies and we highlight challenges facing clinical evaluation of ZIKV vaccine candidates. C1 [Barouch, Dan H.] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Harvard Med Sch, Boston, MA 02215 USA. [Barouch, Dan H.] Ragon Inst MGH MIT Harvard, Cambridge, MA 02139 USA. [Thomas, Stephen J.] State Univ New York, Upstate Med Univ, Syracuse, NY 13210 USA. [Michael, Nelson L.] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD 20910 USA. RP Barouch, DH (reprint author), Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Harvard Med Sch, Boston, MA 02215 USA.; Barouch, DH (reprint author), Ragon Inst MGH MIT Harvard, Cambridge, MA 02139 USA. EM dbarouch@bidmc.harvard.edu FU U.S. Military Research and Materiel Command; U.S. Military HIV Research Program [W81XWH-11-2-0174]; NIH [AI095985, AI096040, AI100663, AI124377]; Ragon Institute of MGH, MIT, and Harvard FX We acknowledge support from the U.S. Military Research and Materiel Command and the U.S. Military HIV Research Program (W81XWH-11-2-0174), the NIH (AI095985, AI096040, AI100663, AI124377), and the Ragon Institute of MGH, MIT, and Harvard. The views expressed in this manuscript are those of the authors and do not represent the official views of the Department of the Army or the Department of Defense. NR 78 TC 0 Z9 0 U1 4 U2 4 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1074-7613 EI 1097-4180 J9 IMMUNITY JI Immunity PD FEB 21 PY 2017 VL 46 IS 2 BP 176 EP 182 DI 10.1016/j.immuni.2017.02.005 PG 7 WC Immunology SC Immunology GA EO0TM UT WOS:000396410900007 PM 28228277 ER PT J AU Deng, ZD Martinez, JJ Li, H Harnish, RA Woodley, CM Hughes, JA Li, X Fu, T Lu, J McMichael, GA Weiland, MA Eppard, MB Skalski, JR Townsend, RL AF Deng, Z. D. Martinez, J. J. Li, H. Harnish, R. A. Woodley, C. M. Hughes, J. A. Li, X. Fu, T. Lu, J. McMichael, G. A. Weiland, M. A. Eppard, M. B. Skalski, J. R. Townsend, R. L. TI y Comparing the survival rate of juvenile Chinook salmon migrating through hydropower systems using injectable and surgical acoustic transmitters SO SCIENTIFIC REPORTS LA English DT Article ID SWIMMING PERFORMANCE; TELEMETRY SYSTEM; BUOYANCY COMPENSATION; DUMMY TRANSMITTERS; COLUMBIA RIVER; IMPLANTATION; FISH; TEMPERATURE; MORTALITY; GROWTH AB Acoustic telemetry is one of the primary technologies for studying the behavior and survival of fishes throughout the world. The size and performance of the transmitter are key limiting factors. The newly developed injectable transmitter is the first acoustic transmitter that can be implanted via injection instead of surgery. A two-part field study was conducted to evaluate the performance of the injectable transmitter and its effect on the survival of implanted fish. The injectable transmitter performed well and similarly to the proceeding generation of commercially-available JSATS transmitters tested concurrently. Snake River subyearling Chinook salmon smolts implanted with the injectable transmitter had a higher survival probability from release to each of eleven downstream detection arrays, because reach-specific survival estimates were significantly higher for the injectable group in three of the eleven reaches examined. Overall, the injectable group had a 0.263 (SE = 0.017) survival probability over the entire 500 km study area compared to 0.199 (0.012) for the surgically implanted group. The reduction in size and ability to implant the new transmitter via injection has reduced the tag or tagging effect bias associated with studying small fishes. The information gathered with this new technology is helping to evaluate the impacts of dams on fishes. C1 [Deng, Z. D.; Martinez, J. J.; Li, H.; Harnish, R. A.; Woodley, C. M.; Hughes, J. A.; Li, X.; Fu, T.; Lu, J.; McMichael, G. A.; Weiland, M. A.] Pacific Northwest Natl Lab, POB 999, Richland, WA 99332 USA. [Eppard, M. B.] US Army, Corps Engineers, 333 SW First Ave, Portland, OR 97204 USA. [Skalski, J. R.; Townsend, R. L.] Univ Washington, Sch Aquat & Fishery Sci, 1325 Fourth Ave,Suite 1820, Seattle, WA 98101 USA. [Woodley, C. M.] US Army, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39810 USA. [McMichael, G. A.] Mainstem Fish Res, 65 Pk St, Richland, WA 99354 USA. RP Deng, ZD (reprint author), Pacific Northwest Natl Lab, POB 999, Richland, WA 99332 USA. EM zhiqun.deng@pnnl.gov RI Deng, Daniel/A-9536-2011 OI Deng, Daniel/0000-0002-8300-8766 FU U.S. Army Corps of Engineers (USACE) Portland District; USACE Walla Walla District FX This study was funded by U.S. Army Corps of Engineers (USACE) Portland District and the Performance Standard Evaluations study was funded by the USACE Walla Walla District. We greatly appreciate the assistance of USACE staff members Derek Fryer, Eric Hockersmith, Mike Langeslay, Steve Juhnke, Marvin Shutters, Brad Trumbo, and Tim Wik. We also are grateful to many staff of Pacific Northwest National Laboratory, Pacific States Marine Fisheries Commission, and the University of Washington for their technical help and field support. NR 49 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD FEB 21 PY 2017 VL 7 BP 1 EP 8 AR 42999 DI 10.1038/srep42999 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL6OI UT WOS:000394741500001 PM 28220850 ER PT J AU Vazquez-Cintron, EJ Beske, PH Tenezaca, L Tran, BQ Oyler, JM Glotfelty, EJ Angeles, CA Syngkon, A Mukherjee, J Kalb, SR Band, PA McNutt, PM Shoemaker, CB Ichtchenko, K AF Vazquez-Cintron, Edwin J. Beske, Phillip H. Tenezaca, Luis Tran, Bao Q. Oyler, Jonathan M. Glotfelty, Elliot J. Angeles, Christopher A. Syngkon, Aurelia Mukherjee, Jean Kalb, Suzanne R. Band, Philip A. McNutt, Patrick M. Shoemaker, Charles B. Ichtchenko, Konstantin TI Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery SO SCIENTIFIC REPORTS LA English DT Article ID BIOLOGICAL-ACTIVITY; GANGLIOSIDES; BINDING; PROTEIN; TOXIN; MOUSE; EXPRESSION; SURVIVAL; RECEPTOR; HYBRID AB Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic compartments with exquisite specificity. While the native toxin is extremely lethal, bioengineering of BoNT has the potential to eliminate toxicity without disrupting neuron-specific targeting, thereby creating a molecular vehicle capable of delivering therapeutic cargo into the neuronal cytosol. Building upon previous work, we have developed an atoxic derivative (ad) of BoNT/C1 through rationally designed amino acid substitutions in the metalloprotease domain of wild type (wt) BoNT/C1. To test if BoNT/C1 ad retains neuron-specific targeting without concomitant toxic host responses, we evaluated the localization, activity, and toxicity of BoNT/C1 ad in vitro and in vivo. In neuronal cultures, BoNT/C1 ad light chain is rapidly internalized into presynaptic compartments, but does not cleave SNARE proteins nor impair spontaneous neurotransmitter release. In mice, systemic administration resulted in the specific co-localization of BoNT/C1 ad with diaphragmatic motor nerve terminals. The mouse LD50 of BoNT/C1 ad is 5 mg/kg, with transient neurological symptoms emerging at sub-lethal doses. Given the low toxicity and highly specific neuron-targeting properties of BoNT/C1 ad, these data suggest that BoNT/C1 ad can be useful as a molecular vehicle for drug delivery to the neuronal cytoplasm. C1 [Vazquez-Cintron, Edwin J.; Tenezaca, Luis; Angeles, Christopher A.; Syngkon, Aurelia; Band, Philip A.; Ichtchenko, Konstantin] NYU, Dept Biochem & Mol Pharmacol, Sch Med, New York, NY 10016 USA. [Vazquez-Cintron, Edwin J.; Tenezaca, Luis; Band, Philip A.] CytoDel LLC, New York, NY 10027 USA. [Vazquez-Cintron, Edwin J.; Beske, Phillip H.; Oyler, Jonathan M.; Glotfelty, Elliot J.; McNutt, Patrick M.] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Tran, Bao Q.] Excet Inc, 6225 Brandon Ave,Suite 360, Springfield, VA 22150 USA. [Mukherjee, Jean; Shoemaker, Charles B.] Tufts Univ, Dept Infect Dis & Global Hlth, Clin & Translat Sci Inst, North Grafton, MA 01536 USA. [Kalb, Suzanne R.] Ctr Dis Control & Prevent, Natl Ctr Environm Health, Agcy Tox Subst & Dis Registry, Atlanta, GA 30341 USA. [Band, Philip A.] NYU, Dept Orthopaed Surg, Hosp Joint Dis, New York, NY 10016 USA. RP Ichtchenko, K (reprint author), NYU, Dept Biochem & Mol Pharmacol, Sch Med, New York, NY 10016 USA. EM Konstantin.Ichtchenko@nyumc.org FU NIAID [R01AI093504, R01AI093467] FX This study was supported by NIAID awards R01AI093504 to K.I. and R01AI093467 to C.B.S. We thank Dr. Eric A. Johnson (University of Wisconsin at Madison) for providing wt BoNT/C1, Drs. Jianlong Lou and James Marks (University of California at San Francisco) for providing the monoclonal antibodies against BoNT/C1 used in the laboratory of K.I. for this study. We are also grateful for the thoughts generated as a result of discussion with Dr. Cesare Montecucco (University of Padova, Italy). The authors also thank Dr. Eric Milner for reading and careful editing of the manuscript. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 43 TC 0 Z9 0 U1 3 U2 3 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD FEB 21 PY 2017 VL 7 AR 42923 DI 10.1038/srep42923 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL3EP UT WOS:000394502700001 PM 28220863 ER PT J AU Shang, YM Wang, GS Sliney, DH Yang, CH Lee, LL AF Shang, Yu-Man Wang, Gen-Shuh Sliney, David H. Yang, Chang-Hao Lee, Li-Ling TI Light-emitting-diode induced retinal damage and its wavelength dependency in vivo SO INTERNATIONAL JOURNAL OF OPHTHALMOLOGY LA English DT Article DE retinal light injury; LED light injury; blue light injury; iron; light injury mechanisms; oxidative stress ID INDUCED PHOTORECEPTOR DEGENERATION; PIGMENT EPITHELIAL-CELLS; BRIGHT CYCLIC LIGHT; BLUE-LIGHT; INDUCED APOPTOSIS; MACULAR DEGENERATION; RETINITIS-PIGMENTOSA; OXIDATIVE DAMAGE; RAT RETINA; LED LIGHT AB AIM: To examine light-emitting-diode (LED)-induced retinal neuronal cell damage and its wavelength-driven pathogenic mechanisms. METHODS: Sprague-Dawley rats were exposed to blue LEDs (460 nm), green LEDs (530 nm), and red LEDs (620 nm). Electroretinography (ERG), Hematoxylin and eosin (H&E) staining, transmission electron microscopy (TEM), terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), and immunohistochemical (INC) staining, Western blotting (WB) and the detection of superoxide anion (02), hydrogen peroxide (H2O2), total iron, and ferric (Fe3+ levels were applied. RESULTS: ERG results showed the blue LED group induced more functional damage than that of green or red LED groups. H&E staining, TUNEL, IHC, and TEM revealed apoptosis and necrosis of photoreceptors and RPE, which indicated blue LED also induced more photochemical injury. Free radical production and iron-related molecular marker expressions demonstrated that oxidative stress and iron overload were associated with retinal injury. WB assays correspondingly showed that defense gene expression was up-regulated after the LED light exposure with a wavelength dependency. CONCLUSION: The study results indicate that LED blue light exposure poses a great risk of retinal injury in awake, task-oriented rod-dominant animals. The wavelength dependent effect should be considered carefully when switching to LED lighting applications. C1 [Shang, Yu-Man; Wang, Gen-Shuh] Natl Taiwan Univ, Inst Environm Hlth, Taipei 10051, Taiwan. [Sliney, David H.] US Army, Dept Med, Aberdeen Proving Ground, MD 21010 USA. [Yang, Chang-Hao] Natl Taiwan Univ, Dept Ophthalmol, Sch Med, Taipei 10051, Taiwan. [Yang, Chang-Hao] Natl Taiwan Univ Hosp, Dept Ophthalmol, 7 Chung Shan South Rd, Taipei 10051, Taiwan. [Lee, Li-Ling] Ind Technol Res Inst, Green Energy & Environm Res Labs, Hsinchu 31040, Taiwan. RP Yang, CH (reprint author), Natl Taiwan Univ Hosp, Dept Ophthalmol, 7 Chung Shan South Rd, Taipei 10051, Taiwan. EM chyangoph@ntu.edu.tw FU Taiwan Ministry of Science and Technology [NSC 103-2314-B-002-076-MY3] FX Supported by Taiwan Ministry of Science and Technology grant (No.NSC 103-2314-B-002-076-MY3). NR 60 TC 0 Z9 0 U1 0 U2 0 PU IJO PRESS PI XI AN PA NO 269 YOUYI EAST RD, XI AN, 710054, PEOPLES R CHINA SN 2222-3959 EI 2227-4898 J9 INT J OPHTHALMOL-CHI JI Int. J. Ophthalmol. PD FEB 18 PY 2017 VL 10 IS 2 BP 191 EP 202 DI 10.18240/ijo.2017.02.03 PG 12 WC Ophthalmology SC Ophthalmology GA EL2VM UT WOS:000394478600003 PM 28251076 ER PT J AU Mitchell, NJ Hsu, HH Chandyo, RK Shrestha, B Bodhidatta, L Tu, YK Gong, YY Egner, PA Ulak, M Groopman, JD Wu, F AF Mitchell, Nicole J. Hsu, Hui-Husan Chandyo, Ram Krishna Shrestha, Binob Bodhidatta, Ladaporn Tu, Yu-Kang Gong, Yun-Yun Egner, Patricia A. Ulak, Manjeswori Groopman, John D. Wu, Felicia TI Aflatoxin exposure during the first 36 months of life was not associated with impaired growth in Nepalese children: An extension of the MAL-ED study SO PLOS ONE LA English DT Article ID DILUTION MASS-SPECTROMETRY; YOUNG-CHILDREN; WEST-AFRICA; DEVELOPING-COUNTRIES; ALBUMIN ADDUCTS; BIRTH COHORT; BENIN; UNDERNUTRITION; TOGO; BIOMARKERS AB Exposure to aflatoxin, a mycotoxin common in many foods, has been associated with child growth impairment in sub-Saharan Africa. To improve our understanding of growth impairment in relation to aflatoxin and other risk factors, we assessed biospecimens collected in Nepalese children at 15, 24, and 36 months of age for aflatoxin exposure. Children ( N = 85) enrolled in the Bhaktapur, Nepal MAL-ED study encompassed the cohort analysed in this study. Exposure was assessed through a plasma biomarker of aflatoxin exposure: the AFB1-lysine adduct. The aflatoxin exposures in the study participants were compared to anthropometrics at each time period ( length-for-age [ LAZ], weight-for-age [ WAZ], and weight-for-length [ WLZ] z-scores), growth trajectories over time, age, and breastfeeding status. Results demonstrated chronic aflatoxin exposure in this cohort of children, with a geometric mean of 3.62 pg AFB1-lysine/mg albumin. However, the chronic aflatoxin exposure in this cohort was not significantly associated with anthropometric z-scores, growth trajectories, age, or feeding status, based on the available time points to assess aflatoxin exposure. Low mean levels of aflatoxin exposure and infrequent occurrence of stunting, wasting, or underweight z-score values in this cohort are possible contributing factors to a lack of evidence for an association. Further research is needed to examine whether a threshold dose of aflatoxin exists that could induce child growth impairment. C1 [Mitchell, Nicole J.; Wu, Felicia] Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA. [Hsu, Hui-Husan; Tu, Yu-Kang] Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan. [Chandyo, Ram Krishna] Univ Bergen, Ctr Intervent Sci Maternal & Child Hlth, Ctr Int Hlth, Bergen, Norway. [Chandyo, Ram Krishna; Ulak, Manjeswori] Tribhuvan Univ, Inst Med, Dept Child Hlth, Kathmandu, Nepal. [Shrestha, Binob] Walter Reed Armed Forces Res Inst Med Sci, Res Unit, Kathmandu, Nepal. [Bodhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok, Thailand. [Gong, Yun-Yun] Queens Univ Belfast, Inst Global Food Secur, Sch Biol Sci, Belfast, Antrim, North Ireland. [Egner, Patricia A.; Groopman, John D.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA. RP Wu, F (reprint author), Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA. EM fwu@msu.edu NR 42 TC 0 Z9 0 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 17 PY 2017 VL 12 IS 2 AR e0172124 DI 10.1371/journal.pone.0172124 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL2BI UT WOS:000394424700018 PM 28212415 ER PT J AU Kotan, H Darling, KA AF Kotan, Hasan Darling, Kris A. TI Phase transformation and grain growth behavior of a nanocrystalline 18/8 stainless steel SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Stainless steels; Martensitic transformation; Grain growth; Phase transformation; High temperature x-ray diffraction; Metastable austenite ID DEFORMATION-INDUCED MARTENSITE; SEVERE PLASTIC-DEFORMATION; X-RAY-DIFFRACTION; METASTABLE AUSTENITIC STEEL; STRAIN-INDUCED MARTENSITE; MECHANICAL-PROPERTIES; THERMAL-STABILITY; MICROSTRUCTURAL EVOLUTION; START TEMPERATURE; AISI 304-STAINLESS-STEEL AB Fe-18Cr-8Ni and Fe-18Cr-8Ni-1Y (at%) stainless steel powders were nanostructured by mechanical alloying from elemental powders and subjected to 90 min annealing treatments at various temperatures. The microstructural evolutions as a function of alloy compositions and temperatures were investigated by in-situ and ex-situ x-ray diffraction experiments, transmission electron microscopy and focused ion beam microscopy. The dependence of hardness on the microstructure was utilized to study the mechanical changes. It was found that the resulting microstructures by mechanical alloying were bcc solid solution, the so-called alpha'-martensite structure. The high temperature in-situ x-ray diffraction experiments showed that the martensite-to-austenite reverse phase transformation was completed above 800 and 900 degrees C for Fe-18Cr-8Ni and Fe-18Cr-8Ni-1Y steels, respectively. A partial or complete retransformation to martensite was observed upon cooling to room temperature. Annealing of nanocrystalline Fe-18Cr-8Ni steel yielded grain growth reaching to micron sizes at 1100 degrees C while addition of 1 at% yttrium stabilized the microstructure around 160 nm grain size and 6 GPa hardness after 90 min annealing at 1200 degrees C. C1 [Kotan, Hasan] Konya Necmettin Erbakan Univ, Dept Met & Mat Engn, TR-42090 Konya, Turkey. [Darling, Kris A.] US Army, Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP Kotan, H (reprint author), Konya Necmettin Erbakan Univ, Dept Met & Mat Engn, TR-42090 Konya, Turkey. EM hasankotan@gmail.com FU TUBITAK [3501 - 114M214] FX The financial support from TUBITAK through the project 3501 - 114M214 is gratefully acknowledged. NR 77 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD FEB 16 PY 2017 VL 686 BP 168 EP 175 DI 10.1016/j.msea.2017.01.031 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA EK6YX UT WOS:000394073300020 ER PT J AU Price, DL Borodin, O Gonzalez, M Kofu, M Shibata, K Yamada, T Yamamuro, O Saboungi, ML AF Price, David L. Borodin, Oleg Gonzalez, Miguel Kofu, Maiko Shibata, Kaoru Yamada, Takeshi Yamamuro, Osamu Saboungi, Marie-Louise TI Relaxation in a Prototype Ionic Liquid: Influence of Water on the Dynamics SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS LA English DT Article ID POLARIZABLE FORCE-FIELD; 1-BUTYL-3-METHYLIMIDAZOLIUM TETRAFLUOROBORATE; AQUEOUS-SOLUTION; IMIDAZOLIUM; SIMULATIONS; MIXTURES; SPECTROSCOPY; VISCOSITY AB The influence of water on the relaxation of a prototype ionic liquid (IL) C(8)mimBF(4) is examined in the IL-rich regime combining quasi-elastic neutron scattering (QENS) and molecular dynamics (MD) simulations. The QENS and MD simulations results for relaxation of IL and the equimolar mixture with water probed by the dynamics of the C(8)mim hydrogen atoms in the time range of 2 ps to 1 ns are in excellent agreement. The QENS data show that translational relaxation increases by a factor of 7 on the addition of water, while rotational relaxation involving multiple processes fitted by a KWW function with low beta values is speeded up by a factor of 3 on the time scale of QENS measurements. The MD simulations show that the cation diffusion coefficient, inverse viscosity, and ionic conductivity increase on the addition of water, consistent with the very small change in ionicity. The difficulties in obtaining rotational and translational diffusion coefficients from fits to QENS experiments of pure ILs and IL-water mixtures are discussed. C1 [Price, David L.] CNRS, UPR 3079, 1d Ave Rech Sci, F-45071 Orleans 2, France. [Price, David L.] Univ Orleans, Condit Extremes & Mat Haute Temp & Irradiat, 1d Ave Rech Sci, F-45071 Orleans 2, France. [Borodin, Oleg] US Army, Res Lab, Electrochem Branch, Sensor & Elect Devices Directorate, Adelphi, MD 20783 USA. [Gonzalez, Miguel] Inst Laue Langevin, 71 Ave Martyrs, F-38042 Grenoble 9, France. [Kofu, Maiko; Yamamuro, Osamu] Univ Tokyo, Inst Solid State Phys, 5-1-5 Kashiwanoha, Kashiwa, Chiba 2778581, Japan. [Shibata, Kaoru] JAEA, J PARC Ctr, Mat & Life Sci Div, Tokai, Ibaraki 3191195, Japan. [Yamada, Takeshi] CROSS Tokai, Neutron R&D Div, Tokai, Ibaraki 3191106, Japan. [Saboungi, Marie-Louise] Univ Paris 06, IMPMC, 4 Pl Jussieu, F-75252 Paris, France. [Saboungi, Marie-Louise] CNRS, 4 Pl Jussieu, F-75252 Paris, France. [Saboungi, Marie-Louise] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China. RP Borodin, O (reprint author), US Army, Res Lab, Electrochem Branch, Sensor & Elect Devices Directorate, Adelphi, MD 20783 USA.; Saboungi, ML (reprint author), Univ Paris 06, IMPMC, 4 Pl Jussieu, F-75252 Paris, France.; Saboungi, ML (reprint author), CNRS, 4 Pl Jussieu, F-75252 Paris, France.; Saboungi, ML (reprint author), Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China. EM oleg.a.borodin.civ@mail.mil; ml.saboungi@gmail.com FU Japan Society for the Promotion of Science; National Science Foundation [DMR-0944772] FX We thank Professor L. Paulo Rebelo for helpful discussions of phase diagrams. We are grateful to Professor M. Arai and J-PARC staff for their help and scientific discussions. D.L.P. acknowledges a visiting appointment at J-PARC, Tokai, Japan, and M.-L.S. acknowledges a fellowship from the Japan Society for the Promotion of Science. The DAVE data analysis software suite was developed at NIST in work supported by the National Science Foundation under agreement no. DMR-0944772. Justin Hooper (University of Utah) assisted with the TOC graphic. NR 31 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7185 J9 J PHYS CHEM LETT JI J. Phys. Chem. Lett. PD FEB 16 PY 2017 VL 8 IS 4 BP 715 EP 719 DI 10.1021/acs.jpclett.6b02871 PG 5 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA EL2XN UT WOS:000394484100002 PM 28103664 ER PT J AU Pioskonka, AM Marzen, SE DeCoste, JB AF Ploskonka, Ann M. Marzen, Stephanie E. DeCoste, Jared B. TI Facile Synthesis and Direct Activation of Zirconium Based Metal-Organic Frameworks from Acetone SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID WATER STABILITY; AGENT SIMULANTS; CARBON-DIOXIDE; DRUG-DELIVERY; BUILDING UNIT; SURFACE-AREAS; PORE-SIZE; UIO-66; ADSORPTION; FUNCTIONALITY AB In recent years much emphasis has been placed on the synthesis of highly novel metal organic frameworks (MOFs) with general disregard to development of sustainable synthesis techniques. A novel synthesis of UiO-66 and UiO-66-NH2, two highly stable MOFs that have shown much promise in the area of catalysis and reactive removal of small molecules, from acetone is demonstrated here. Using this method, the MOFs can be activated by simple heating under vacuum without the need for solvent exchange, which can be a timely processing step that requires the use of large amounts of solvent. The activity of the series of MOFs synthesized at various temperatures was determined by the rate of hydrolysis of methyl paraoxon and the reactive capacity of UiO-66-NH2 with chlorine gas. Direct correlations were observed between synthesis temperature, crystallinity, BET surface area, and activity of the MOFs. C1 [Ploskonka, Ann M.; Marzen, Stephanie E.] Leidos Inc, POB 68, Aberdeen Proving Ground, MD 21010 USA. [DeCoste, Jared B.] US Army, Edgewood Chem Biol Ctr, Res Dev & Engn Command, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. RP DeCoste, JB (reprint author), US Army, Edgewood Chem Biol Ctr, Res Dev & Engn Command, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM jared.b.decoste2.civ@mail.mil FU Joint Science and Technology Office for Chemical Biological Defense (JSTO-CBD) [BA13PHM210] FX The authors thank the Joint Science and Technology Office for Chemical Biological Defense (JSTO-CBD) for funding under project number BA13PHM210, Mr. Matthew Browe for conducting microbreakthrough testing, and Dr. Trenton Tovar for N2 isotherm measurements. NR 47 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD FEB 15 PY 2017 VL 56 IS 6 BP 1478 EP 1484 DI 10.1021/acs.iecr.6b04361 PG 7 WC Engineering, Chemical SC Engineering GA EL2WV UT WOS:000394482100012 ER PT J AU Kiss, L Holmes, S Chou, CE Dong, XM Ross, J Brown, D Mendenhall, B Coronado, V De Silva, D Rockwood, GA Petrikovics, I Thompson, DE AF Kiss, Lorand Holmes, Secondra Chou, Ching-En Dong, Xinmei Ross, James Brown, Denise Mendenhall, Brooke Coronado, Valerie De Silva, Deepthika Rockwood, Gary A. Petrikovics, Ilona Thompson, David E. TI Method development for detecting the novel cyanide antidote dimethyl trisulfide from blood and brain, and its interaction with blood SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE Dimethyl trisulfide; Dimethyl disulfide; Dibuthyl disulfide; HPLC; GC-MS; SPME ID MOUSE-BRAIN AB The antidotal potency of dimethyl trisulfide (DMTS) against cyanide poisoning was discovered and investigated in our previous studies. Based on our results it has better efficacy than the Cyanokit and the Nithiodote therapies that are presently used against cyanide intoxication in the US. Because of their absence in the literature, the goal of this work was to develop analytical methods for determining DMTS from blood and brain that could be employed in future pharmacokinetic studies. An HPLC-UV method for detection of DMTS from blood, a GC-MS method for detection of DMTS from brain, and associated validation experiments are described here. These analytical methods were developed using in vitro spiking of brain and blood, and are suitable for determining the in vivo DMTS concentrations in blood and brain in future pharmacokinetic and distribution studies. An important phenomenon was observed in the process of developing these methods. Specifically, recoveries from fresh blood spiked with DMTS were found to be significantly lower than recoveries from aged blood spiked in the same manner with DMTS. This decreased DMTS recovery from fresh blood is important, both because of the role it may play in the antidotal action of DMTS in the presence of cyanide, and because it adds the requirement of sample stabilization to the method development process. Mitigation procedures for stabilizing DMTS samples in blood are reported. (C) 2017 Elsevier B.V. All rights reserved. C1 [Kiss, Lorand; Holmes, Secondra; Chou, Ching-En; Dong, Xinmei; Ross, James; Brown, Denise; Mendenhall, Brooke; Coronado, Valerie; De Silva, Deepthika; Petrikovics, Ilona; Thompson, David E.] Sam Houston State Univ, Dept Chem, POB 2117, Huntsville, TX 77341 USA. [Rockwood, Gary A.] US Army Med Res Inst Chem Def, 2900 Rickets Point Rd, Aberdeen Proving Ground, MD 21010 USA. RP Thompson, DE (reprint author), Sam Houston State Univ, Dept Chem, POB 2117, Huntsville, TX 77341 USA. EM david.thompson@shsu.edu FU CounterACT Program, National Institutes of Health Office of the Director; National Institute of Allergy and Infectious Diseases, NIH/Department of Defense Interagency Agreement [Y1-OD-0690-01/AOD13016-001-00000/A120-B.P2013-01, Y1-OD-0690-01/AOD14020-001-00000/A120-B.P2014-01]; Robert A. Welch Foundation at Sam Houston State University, Huntsville, TX [X-0011] FX We gratefully acknowledge the support from the CounterACT Program, National Institutes of Health Office of the Director, and the National Institute of Allergy and Infectious Diseases, NIH/Department of Defense Interagency Agreement (Y1-OD-0690-01/AOD13016-001-00000/A120-B.P2013-01, and Y1-OD-0690-01/AOD14020-001-00000/A120-B.P2014-01); and the Robert A. Welch Foundation (X-0011) at Sam Houston State University, Huntsville, TX. NR 17 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 EI 1873-376X J9 J CHROMATOGR B JI J. Chromatogr. B PD FEB 15 PY 2017 VL 1044 BP 149 EP 157 PG 9 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA EL2TF UT WOS:000394472400020 PM 28110144 ER PT J AU Dretsch, MN Silverberg, N Gardner, AJ Panenka, WJ Emmerich, T Crynen, G Ait-Ghezala, G Chaytow, H Mathura, V Crawford, FC Iverson, GL AF Dretsch, Michael N. Silverberg, Noah Gardner, Andrew J. Panenka, William J. Emmerich, Tanja Crynen, Gogce Ait-Ghezala, Ghania Chaytow, Helena Mathura, Venkat Crawford, Fiona C. Iverson, Grant L. TI Genetics and Other Risk Factors for Past Concussions in Active-Duty Soldiers SO JOURNAL OF NEUROTRAUMA LA English DT Article DE APOE; BDNF; concussion; DRD2; genetics; mild traumatic brain injury; military; personality ID TRAUMATIC BRAIN-INJURY; NEUROTROPHIC FACTOR; APOE PROMOTER; PSYCHIATRIC-DISORDERS; AGGRESSIVE-BEHAVIOR; META-REGRESSION; SPONTANEOUS SAH; HEAD-INJURY; ALCOHOL-USE; ASSOCIATION AB Risk factors for concussion in active-duty military service members are poorly understood. The present study examined the association between self-reported concussion history and genetics (apolipoprotein E [APOE], brain-derived neurotrophic factor [BDNF], and D2 dopamine receptor genes [DRD2]), trait personality measures (impulsive-sensation seeking and trait aggression-hostility), and current alcohol use. The sample included 458 soldiers who were preparing to deploy for Operation Iraqi Freedom/Operation Enduring Freedom. For those with the BDNFMet/Met genotype, 57.9% (11/19) had a history of one or more prior concussions, compared with 35.6% (154/432) of those with other BDNF genotypes (p = 0.049, odds ratio [OR] = 2.48). APOE and DRD2 genotypes were not associated with risk for past concussions. Those with the BDNF Met/Met genotype also reported greater aggression and hostility personality characteristics. When combined in a predictive model, prior military deployments, being male, and having the BDNF Met/Met genotype were independently associated with increased lifetime history of concussions in active-duty soldiers. Replication in larger independent samples is necessary to have more confidence in both the positive and negative genetic associations reported in this study. C1 [Dretsch, Michael N.] US Army Aeromed Res Lab, Ft Rucker, AL USA. [Dretsch, Michael N.] Headquarters Army Training & Doctrine Command HQ, Human Dimens Div, Ft Eustis, VA USA. [Silverberg, Noah] Univ British Columbia, Div Phys Med & Rehabil, Vancouver, BC, Canada. [Panenka, William J.] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada. [Silverberg, Noah] GF Strong Rehabil Ctr, Vancouver, BC, Canada. [Silverberg, Noah; Emmerich, Tanja; Crynen, Gogce; Ait-Ghezala, Ghania; Chaytow, Helena; Mathura, Venkat; Crawford, Fiona C.] Roskamp Inst, Sarasota, FL USA. [Gardner, Andrew J.] Univ Newcastle, Sch Med & Publ Hlth, Hunter New England Local Hlth Dist Sports Concuss, Newcastle, NSW, Australia. [Gardner, Andrew J.] Univ Newcastle, Sch Med & Publ Hlth, Ctr Stroke & Brain Injury, Newcastle, NSW, Australia. [Iverson, Grant L.] Harvard Med Sch, Dept Phys Med & Rehabil, Boston, MA USA. [Iverson, Grant L.] Red Sox Fdn, Spaulding Rehabil Hosp & Home Base, Boston, MA USA. [Iverson, Grant L.] Massachusetts Gen Hosp, Home Base Program, Boston, MA 02114 USA. [Iverson, Grant L.] Def & Vet Brain Injury Ctr, Bethesda, MD USA. RP Dretsch, MN (reprint author), Headquarters Training & Doctrine Command, Army Capabil Integrat Ctr, Human Dimens Div, 950 Jefferson Ave, Ft Eustis, VA 23604 USA. EM michael.n.dretsch.mil@mail.mil FU INTRuST Posttraumatic Stress Disorder and Traumatic Brain Injury Clinical Consortium - Department of Defense Psychological Health/Traumatic Brain Injury Research Program [X81XWH-07-CC-CSDoD]; New South Wales Sporting Injuries Committee-Sports Research & Injury Prevention; Brain Foundation; Australia-Brain Injury Award; Hunter Medical Research Institute (HMRI); Australian Football League (AFL) FX Grant L. Iverson acknowledges support from the INTRuST Posttraumatic Stress Disorder and Traumatic Brain Injury Clinical Consortium funded by the Department of Defense Psychological Health/Traumatic Brain Injury Research Program (X81XWH-07-CC-CSDoD). Andrew J. Gardner acknowledges funding from the New South Wales Sporting Injuries Committee-Sports Research & Injury Prevention Scheme, the Brain Foundation, Australia-Brain Injury Award, Hunter Medical Research Institute (HMRI) early career funding through Anne Greaves, and research fellowship funding from Jennie Thomas, Life Governor of the HMRI. Grant L. Iverson has been reimbursed by the government, professional scientific bodies, and commercial organizations for discussing or presenting research relating to mild TBI and sport-related concussion at meetings, scientific conferences, and symposiums. He has a clinical practice in forensic neuropsychology involving individuals who have sustained mild TBIs (including athletes). He has received honoraria for serving on research panels that provide scientific peer review of programs. He is a co-investigator, collaborator, or consultant on grants relating to mild TBI funded by several organizations. Andrew J. Gardner has a clinical practice in neuropsychology involving the assessment and management of individuals who have sustained sport-related concussion (including current and former athletes). He received travel funding from the Australian Football League (AFL) to present at the Concussion in Football Conference in 2013. He also serves in a unremunerated capacity as a member of the Concussion Advisory Group for the Australian Rugby Union (ARU). The other authors have nothing to disclose. NR 48 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD FEB 15 PY 2017 VL 34 IS 4 BP 869 EP 875 DI 10.1089/neu.2016.4480 PG 7 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA EL0XD UT WOS:000394344200014 PM 27396498 ER PT J AU Wang, Y Wei, YL Oguntayo, S Wilder, D Tong, L Su, Y Gist, I Arun, P Long, JB AF Wang, Ying Wei, Yanling Oguntayo, Samuel Wilder, Donna Tong, Lawrence Su, Yan Gist, Irene Arun, Peethambaran Long, Joseph B. TI Cerebrospinal Fluid Chemokine (C-C Motif) Ligand 2 Is an Early-Response Biomarker for Blast-Overpressure-Wave-Induced Neurotrauma in Rats SO JOURNAL OF NEUROTRAUMA LA English DT Article DE biomarker; blast-induced neurotrauma; CCL2; cerebrospinal fluid; chemokines ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; DIFFUSE AXONAL INJURY; NEUROCOGNITIVE DYSFUNCTION; ALZHEIMERS-DISEASE; SERVICE MEMBERS; CORTICAL IMPACT; INFLAMMATION; MICE; CCL2 AB Chemokines and their receptors are of great interest within the milieu of immune responses elicited in the central nervous system in response to trauma. Chemokine (C-C motif)) ligand 2 (CCL2), which is also known as monocyte chemotactic protein-1, has been implicated in the pathogenesis of traumatic brain injury (TBI), brain ischemia, Alzheimer's disease, and other neurodegenerative diseases. In this study, we investigated the time course of CCL2 accumulation in cerebrospinal fluid (CSF) after exposures to single and repeated blast overpressures of varied intensities along with the neuropathological changes and motor deficits resulting from these blast conditions. Significantly increased concentrations of CCL2 in CSF were evident by 1 h of blast exposure and persisted over 24 h with peak levels measured at 6 h post-injury. The increased levels of CCL2 in CSF corresponded with both the number and intensities of blast overpressure and were also commensurate with the extent of neuromotor impairment and neuropathological abnormalities resulting from these exposures. CCL2 levels in CSF and plasma were tightly correlated with levels of CCL2 messenger RNA in cerebellum, the brain region most consistently neuropathologically disrupted by blast. In view of the roles of CCL2 that have been implicated in multiple neurodegenerative disorders, it is likely that the sustained high levels of CCL2 and the increased expression of its main receptor, CCR2, in the brain after blast may similarly contribute to neurodegenerative processes after blast exposure. In addition, the markedly elevated concentration of CCL2 in CSF might be a candidate early-response biomarker for diagnosis and prognosis of blast-induced TBI. C1 [Wang, Ying; Wei, Yanling; Oguntayo, Samuel; Wilder, Donna; Tong, Lawrence; Su, Yan; Gist, Irene; Arun, Peethambaran; Long, Joseph B.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RP Wang, Y (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ying.wang5.ctr@mail.mil; joseph.b.long.civ@mail.mil FU Congressionally Directed Medical Research Program [W81XWH-11-2-0127, W81-XWH-08-2-0018, W81XWH-08-2-0017] FX We thank Dr. James DeMar for useful manuscript corrections and comments and Dr. Yuanzhang Li for valuable suggestions regarding data analysis. Technical guidance and assistance from Stephen VanAlbert and Andrea Edwards are also gratefully acknowledged. This work was supported by Congressionally Directed Medical Research Program awards W81XWH-11-2-0127, W81-XWH-08-2-0018, and W81XWH-08-2-0017. The contents, opinions, and assertions contained herein are private views of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. NR 64 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD FEB 15 PY 2017 VL 34 IS 4 BP 952 EP 962 DI 10.1089/neu.2016.4465 PG 11 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA EL0XD UT WOS:000394344200023 PM 27487732 ER PT J AU Switaj, TL Christensen, SR Brewer, DM AF Switaj, Timothy L. Christensen, Scott R. Brewer, Dean M. TI Acute Coronary Syndrome: Current Treatment SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID ELEVATION MYOCARDIAL-INFARCTION; AMERICAN-HEART-ASSOCIATION; ST-ELEVATION; PRACTICE GUIDELINES; TASK-FORCE; MANAGEMENT; OUTCOMES; REGISTRY; STEMI; INTERVENTION AB Acute coronary syndrome continues to be a significant cause of morbidity and mortality in the United States. Family physicians need to identify and mitigate risk factors early, as well as recognize and respond to acute coronary syndrome events quickly in any clinical setting. Diagnosis can be made based on patient history, symptoms, electrocardiography findings, and cardiac biomarkers, which delineate between ST elevation myocardial infarction and non ST elevation acute coronary syndrome. Rapid reperfusion with primary percutaneous coronary intervention is the goal with either clinical presentation. Coupled with appropriate medical management, percutaneous coronary intervention can improve short-and long-term outcomes following myocardial infarction. If percutaneous coronary intervention cannot be performed rapidly, patients with ST elevation myocardial infarction can be treated with fibrinolytic therapy. Fibrinolysis is not recommended in patients with non ST elevation acute coronary syndrome; therefore, these patients should be treated with medical management if they are at low risk of coronary events or if percutaneous coronary intervention cannot be performed. Post myocardial infarction care should be closely coordinated with the patient's cardiologist and based on a comprehensive secondary prevention strategy to prevent recurrence, morbidity, and mortality. Copyright (C) 2016 American Academy of Family Physicians. C1 [Switaj, Timothy L.] US Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. [Christensen, Scott R.] Martin Army Community Hosp, Family Med Residency Program, Ft Benning, GA USA. [Brewer, Dean M.] Guthrie Ambulatory Hlth Care Clin, Ft Drum, NY USA. RP Switaj, TL (reprint author), US Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. EM timothy.l.switaj.mil@mail.mil NR 21 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD FEB 15 PY 2017 VL 95 IS 4 BP 232 EP 240 PG 9 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA EK4ZZ UT WOS:000393938000003 PM 28290631 ER PT J AU Medina, JL Brooks, EG Chaparro, A Dube, PH AF Medina, Jorge L. Brooks, Edward G. Chaparro, Adriana Dube, Peter H. TI Mycoplasma pneumoniae CARDS toxin elicits a functional IgE response in Balb/c mice SO PLOS ONE LA English DT Article ID MAST-CELLS PROTECT; IMMUNOGLOBULIN-E; PULMONARY INFLAMMATION; VACUOLATING CYTOTOXIN; PERTUSSIS TOXIN; CHRONIC ASTHMA; INFECTION; CHILDREN; ALLERGY; RISK AB Mycoplasma pneumoniae is strongly associated with new onset asthma and asthma exacerbations. Until recently, the molecular mechanisms utilized by M. pneumoniae to influence asthma symptoms were unknown. However, we recently reported that an ADP-ribosylating and vacuolating toxin called the Community Acquired Respiratory Distress Syndrome toxin, CARDS toxin, produced by M. pneumoniae was sufficient to promote allergic inflammation and asthma-like disease in mice. A mouse model of CARDS toxin exposure was used to evaluate total and CARDS-toxin specific serum IgE responses. Mast cell sensitization, challenge, and degranulation studies determined functionality of the CARDS toxin-specific IgE. In the current study, we report that a single mucosal exposure to CARDS toxin was sufficient to increase total serum IgE and CARDS toxin-specific IgE in mice. Mice given a second mucosal challenge of CARDS toxin responded with significant increases in total and CARDS toxin-specific IgE. CARDS toxin-specific IgE bound to an N-terminal peptide of CARDS toxin but not the C-terminal peptide. Likewise, full-length CARDS toxin and the N-terminal peptide induced mast cell degranulation. Altogether, these data demonstrate that exposure to CARDS toxin is sufficient to generate functional IgE in mice. M. pneumoniae and CARDS toxin are strongly associated with asthma exacerbations raising the possibility that the CARDS toxin-specific IgE-mast cell axis contributes to disease pathogenesis. C1 [Medina, Jorge L.; Brooks, Edward G.; Dube, Peter H.] Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA. [Brooks, Edward G.; Chaparro, Adriana] Univ Texas Hlth Sci Ctr San Antonio, Div Immunol & Infect Dis, Dept Pediat, San Antonio, TX 78229 USA. [Medina, Jorge L.] US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX USA. RP Dube, PH (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Microbiol & Immunol, San Antonio, TX 78229 USA. EM Dube@uthscsa.edu FU National Institutes of Health [AI070412] FX This work was supported by a grant from the National Institutes of Health, AI070412, WWW.NIH.GOV. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 64 TC 0 Z9 0 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 15 PY 2017 VL 12 IS 2 AR e0172447 DI 10.1371/journal.pone.0172447 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EL2BF UT WOS:000394424400092 ER PT J AU Takata, H Buranapraditkun, S Kessing, C Fletcher, JLK Muir, R Tardif, V Cartwright, P Vandergeeten, C Bakeman, W Nichols, CN Pinyakorn, S Hansasuta, P Kroon, E Chalermchai, T O'Connell, R Kim, J Phanuphak, N Robb, ML Michael, NL Chomont, N Haddad, EK Ananworanich, J Trautmann, L AF Takata, Hiroshi Buranapraditkun, Supranee Kessing, Cari Fletcher, James L. K. Muir, Roshell Tardif, Virginie Cartwright, Pearline Vandergeeten, Claire Bakeman, Wendy Nichols, Carmen N. Pinyakorn, Suteeraporn Hansasuta, Pokrath Kroon, Eugene Chalermchai, Thep O'Connell, Robert Kim, Jerome Phanuphak, Nittaya Robb, Merlin L. Michael, Nelson L. Chomont, Nicolas Haddad, Elias K. Ananworanich, Jintanat Trautmann, Lydie CA RV254 SEARCH010 Study Grp RV304 SEARCH013 Study Grp TI Delayed differentiation of potent effector CD8(+) T cells reducing viremia and reservoir seeding in acute HIV infection SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; CELLULAR IMMUNE-RESPONSES; VIRUS TYPE-1 INFECTION; HIGHLY PATHOGENIC SIV; IMMUNODEFICIENCY-VIRUS; VIRAL-INFECTION; DISEASE PROGRESSION; DECAY KINETICS; REPLICATION; LYMPHOCYTES AB CD8(+) T cells play a critical role in controlling HIV viremia and could be important in reducing HIV-infected cells in approaches to eradicate HIV. The simian immunodeficiency virus model provided the proof of concept for a CD8(+) T cell-mediated reservoir clearance but showed conflicting evidence on the role of these cells to eliminate HIV-infected cells. In humans, HIV-specific CD8(+) T cell responses have not been associated with a reduction of the HIV-infected cell pool in vivo. We studied HIV-specific CD8(+) T cells in the RV254 cohort of individuals initiating ART in the earliest stages of acute HIV infection (AHI). We showed that the HIV-specific CD8(+) T cells generated as early as AHI stages 1 and 2 before peak viremia are delayed in expanding and acquiring effector functions but are endowed with higher memory potential. In contrast, the fully differentiated HIV-specific CD8(+) T cells at peak viremia in AHI stage 3 were more prone to apoptosis but were associated with a steeper viral load decrease after ART initiation. Their capacity to persist in vivo after ART initiation correlated with a lower HIV DNA reservoir. These findings demonstrate that HIV-specific CD8(+) T cell magnitude and differentiation are delayed in the earliest stages of infection. These results also demonstrate that potent HIV-specific CD8(+) T cells contribute to the reduction of the pool of HIV-producing cells and the HIV reservoir seeding in vivo and provide the rationale to design interventions aiming at inducing these potent responses to cure HIV infection. C1 [Takata, Hiroshi; Buranapraditkun, Supranee; Pinyakorn, Suteeraporn; Robb, Merlin L.; Michael, Nelson L.; Ananworanich, Jintanat; Trautmann, Lydie] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Takata, Hiroshi; Buranapraditkun, Supranee; Pinyakorn, Suteeraporn; Robb, Merlin L.; Ananworanich, Jintanat; Trautmann, Lydie] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA. [Buranapraditkun, Supranee; Hansasuta, Pokrath] Chulalongkorn Univ, Fac Med, Bangkok, Thailand. [Kessing, Cari] Scripps Res Inst, Jupiter, FL 33458 USA. [Fletcher, James L. K.; Kroon, Eugene; Chalermchai, Thep; Phanuphak, Nittaya; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Muir, Roshell; Tardif, Virginie; Haddad, Elias K.] Drexel Univ, Div Infect Dis & HIV Med, Dept Med, Philadelphia, PA 19102 USA. [Cartwright, Pearline] Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA. [Vandergeeten, Claire; Bakeman, Wendy; Nichols, Carmen N.] Vaccine & Gene Therapy Inst Florida, Port St Lucie, FL 34987 USA. [Hansasuta, Pokrath] Univ Oxford, Nuffield Dept Med, Oxford, England. [O'Connell, Robert] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Kim, Jerome] Int Vaccine Inst, Seoul, South Korea. [Chomont, Nicolas] Univ Montreal, Ctr Rech Hosp Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada. RP Trautmann, L (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.; Trautmann, L (reprint author), Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA. EM ltrautmann@hivresearch.org FU NIH [R01AI108433]; Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. [W81XWH-07-2-0067]; U.S. Department of Defense FX This study was supported by the following sources: NIH grant R01AI108433 and a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. and the U.S. Department of Defense. NR 59 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 EI 1946-6242 J9 SCI TRANSL MED JI Sci. Transl. Med. PD FEB 15 PY 2017 VL 9 IS 377 AR eaag1809 DI 10.1126/scitranslmed.aag1809 PG 9 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA EL2LL UT WOS:000394451100004 ER PT J AU Morelli, A Tortonesi, M Stefanelli, C Suri, N AF Morelli, Alessandro Tortonesi, Mauro Stefanelli, Cesare Suri, Niranjan TI Information-Centric Networking in next-generation communications scenarios SO JOURNAL OF NETWORK AND COMPUTER APPLICATIONS LA English DT Article DE Information-Centric Networking; Next-generation communications scenarios; Heterogeneous networks; Information dissemination channels; Network simulation ID TACTICAL ENVIRONMENTS OBSERVATIONS; OPPORTUNISTIC NETWORKS; HETEROGENEOUS NETWORKS; DESIGN; EXPERIENCES; MIDDLEWARE; CAPACITY; DELIVERY; LESS AB Next-generation networking environments, characterized by the overlapping of wireless networks of different types, are emerging as a new and extremely interesting scenario. Their high dynamicity and heterogeneity present significant challenges from the communications perspective, which call for the adoption of new paradigms based on opportunistic and Information-Centric Networking (ICN) approaches. Applications operating in next-generation environments have peculiar characteristics that could benefit from ICN-based middleware solutions. This paper presents ICeDiM, a middleware we designed for ICN communications in next generation scenarios, which builds on top of the innovative concept of Application-level Dissemination Channels (ADCs) with tunable permeability levels. A thorough and in-depth experimental evaluation of ICeDiM in a next-generation environment realistically simulated using ICeONE, a modified version of the well-known ONE simulator, demonstrates that our approach can achieve very good performance levels in terms of delivery ratio and network resource consumption. C1 [Morelli, Alessandro; Tortonesi, Mauro; Stefanelli, Cesare] Univ Ferrara, Dept Engn, Ferrara, Italy. [Suri, Niranjan] US Army Res Lab, Adelphi, MD USA. [Suri, Niranjan] Florida Inst Human & Machine Cognit, Pensacola, FL USA. RP Tortonesi, M (reprint author), Univ Ferrara, Dept Engn, Ferrara, Italy. EM alessandro.morelli@unife.it; mauro.tortonesi@unife.it; cesare.stefanelli@unife.it; niranjan.suri.civ@mail.mil NR 98 TC 0 Z9 0 U1 2 U2 2 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1084-8045 J9 J NETW COMPUT APPL JI J. Netw. Comput. Appl. PD FEB 15 PY 2017 VL 80 BP 232 EP 250 DI 10.1016/j.jnca.2016.12.026 PG 19 WC Computer Science, Hardware & Architecture; Computer Science, Interdisciplinary Applications; Computer Science, Software Engineering SC Computer Science GA EK0OW UT WOS:000393627300019 ER PT J AU Mckee, PJ Sokolow, AC Yu, JH Long, LL Wetzel, ED AF Mckee, P. Justin Sokolow, Adam C. Yu, Jian H. Long, Larry L. Wetzel, Eric D. TI Finite element simulation of ballistic impact on single jersey knit fabric SO COMPOSITE STRUCTURES LA English DT Article DE Knit; Ballistic impact; Finite element analysis (FEA) ID WOVEN FABRICS; STRENGTH; COMPOSITES; BEHAVIOR; YARNS; DEFORMATION; PERFORMANCE; FRICTION; TESTS AB Knitted fabrics are constructed from interlocking loops of yarn. Curvature in the yarn provides stretchability, making them well suited for garments that will cover areas of the body that require large relative motion. Although most current soft armors are composed of woven textiles, knitted fabrics made of aramid fibers such as Kevlar may have application for use in soft armor to provide a larger range of motion in addition to protection. However, their ballistic performance has not been well characterized. The goal of this work is to develop a computational framework to simulate a single jersey knit under ballistic loading. The path and shape of the yarn in the knit fabric is defined with parametric equations calibrated to CT images of a sample fabric. Results of finite element simulations demonstrate the unique mechanical response of knit soft armor, and show qualitative agreement with ballistic experiments. Published by Elsevier Ltd. C1 [Mckee, P. Justin] Bennett Aerosp Inc, Cary, NC USA. [Sokolow, Adam C.; Yu, Jian H.; Long, Larry L.; Wetzel, Eric D.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Wetzel, ED (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM eric.d.wetzel2.civ@mail.mil FU U.S. Army Research Laboratory [W911QX-14-C-0016] FX The research reported in this document was performed in connection with contract/instrument W911QX-14-C-0016 with the U.S. Army Research Laboratory. The views and conclusions contained in this document are those of TKC Global and the U.S. Army Research Laboratory. Citation of manufacturer's or trade names does not constitute an official endorsement or approval of the use thereof. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 28 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 EI 1879-1085 J9 COMPOS STRUCT JI Compos. Struct. PD FEB 15 PY 2017 VL 162 BP 98 EP 107 DI 10.1016/j.compstruct.2016.11.086 PG 10 WC Materials Science, Composites SC Materials Science GA EJ1XY UT WOS:000393005100009 ER PT J AU Boyne, DA Savage, AM Griep, MH Beyer, FL Orlicki, JA AF Boyne, Devon A. Savage, Alice M. Griep, Mark H. Beyer, Frederick L. Orlicki, Joshua A. TI Process induced alignment of gold nano-rods (GNRs) in thermoplastic polymer composites with tailored optical properties SO POLYMER LA English DT Article DE Nanocomposites; Gold nanoparticles; Optical properties ID ENHANCED THERMAL-STABILITY; X-RAY-SCATTERING; NANOPARTICLES AB Manipulation of the electronic and optical properties of plasmonic nanomaterials offers unique and exciting opportunities for several fields including opto-electronics, bio-medical engineering and photovoltaics. In particular, gold nanorods (GNR) represent a class of plasmonic nanomaterials that provide tunable optical properties from the visible to the near infrared regime. Herein, we have developed a highly effective method to prepare polymer nanocomposites (PNCs) doped with GNR additives utilizing extrusion and injection molding. A key outcome is that the process is amenable to scalable manufacturing and can produce highly reproducible PNCs with excellent optical properties. The resultant PNCs display good particle dispersion, minimal aggregation and a high retention of the optical properties as confirmed by UV-Vis spectroscopy and transmission electron microscopy. The nano-additives are incorporated into different thermoplastics to demonstrate the versatility of this method for different matrices and to demonstrate stability over the extrusion processing temperature range (235-335 degrees C). Furthermore, the tractability of this method is demonstrated by incorporating GNRs with different morphologies (aspect ratio, stabilizing layer, etc.). Finally, partial flow-induced alignment is demonstrated, the degree of which is modulated by the length and monodispersity of the GNR nano-additive. Ultimately, we report an optimized methodology to produce high quality GNR-PNCs with tailorable optical properties that can be adapted for scalable manufacturing. C1 [Boyne, Devon A.; Savage, Alice M.; Griep, Mark H.; Beyer, Frederick L.; Orlicki, Joshua A.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Orlicki, JA (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM joshua.a.orlicki.civ@mail.mil FU U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. NR 41 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD FEB 10 PY 2017 VL 110 BP 250 EP 259 DI 10.1016/j.polymer.2016.12.059 PG 10 WC Polymer Science SC Polymer Science GA EL1VV UT WOS:000394410400026 ER PT J AU Esposito, ER Choi, HS Darter, BJ Wilken, JM AF Esposito, Elizabeth Russell Choi, Harmony S. Darter, Benjamin J. Wilken, Jason M. TI Can real-time visual feedback during gait retraining reduce metabolic demand for individuals with transtibial amputation? SO PLOS ONE LA English DT Article ID TRANS-TIBIAL AMPUTEES; BELOW-KNEE AMPUTEES; ENERGY-COST; TRANSFEMORAL AMPUTEES; PHYSICAL-ACTIVITY; WALKING; AMBULATION; PERFORMANCE; EXPENDITURE; PROSTHESES AB The metabolic demand of walking generally increases following lower extremity amputation. This study used real-time visual feedback to modify biomechanical factors linked to an elevated metabolic demand of walking in individuals with transtibial amputation. Eight persons with unilateral, traumatic transtibial amputation and 8 uninjured controls participated. Two separate bouts of real-time visual feedback were provided during a single session of gait retraining to reduce 1) center of mass sway and 2) thigh muscle activation magnitudes and duration. Baseline and post-intervention data were collected. Metabolic rate, heart rate, frontal plane center of mass sway, quadriceps and hamstrings muscle activity, and co-contraction indices were evaluated during steady state walking at a standardized speed. Visual feedback successfully decreased center of mass sway 12% ( p = 0.006) and quadriceps activity 12% ( p = 0.041); however, thigh muscle co-contraction indices were unchanged. Neither condition significantly affected metabolic rate during walking and heart rate increased with center-of-mass feedback. Metabolic rate, center of mass sway, and integrated quadriceps muscle activity were all not significantly different from controls. Attempts to modify gait to decrease metabolic demand may actually adversely increase the physiological effort of walking in individuals with lower extremity amputation who are young, active and approximate metabolic rates of able-bodied adults. C1 [Esposito, Elizabeth Russell; Choi, Harmony S.; Wilken, Jason M.] US Army, Brooke Army Med Ctr, Ctr Intrepid, JBSA, Ft Sam Houston, TX 78234 USA. [Esposito, Elizabeth Russell; Choi, Harmony S.; Wilken, Jason M.] Extrem Trauma & Amputat Ctr Excellence, Ft Sam Houston, TX 78234 USA. [Darter, Benjamin J.] Virginia Commonwealth Univ, Dept Phys Therapy, Richmond, VA USA. RP Esposito, ER (reprint author), US Army, Brooke Army Med Ctr, Ctr Intrepid, JBSA, Ft Sam Houston, TX 78234 USA.; Esposito, ER (reprint author), Extrem Trauma & Amputat Ctr Excellence, Ft Sam Houston, TX 78234 USA. EM erussell.kin@gmail.com FU Telemedicine and Advanced Technology Research Center's AMEDD Advanced Medical Technologies Initiative grant [W911QY-09-D-0043]; National Center for Advancing Translational Sciences grant [KL2TR000057] FX Financial support was provided by a Telemedicine and Advanced Technology Research Centers AMEDD Advanced Medical Technologies Initiative grant (W911QY-09-D-0043) and a National Center for Advancing Translational Sciences grant (KL2TR000057). JMW BJD. NR 51 TC 0 Z9 0 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 9 PY 2017 VL 12 IS 2 AR e0171786 DI 10.1371/journal.pone.0171786 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EK9GJ UT WOS:000394231800111 ER PT J AU Kugelman, JR Wiley, MR Nagle, ER Reyes, D Pfeffer, BP Kuhn, JH Sanchez-Lockhart, M Palacios, GF AF Kugelman, Jeffrey R. Wiley, Michael R. Nagle, Elyse R. Reyes, Daniel Pfeffer, Brad P. Kuhn, Jens H. Sanchez-Lockhart, Mariano Palacios, Gustavo F. TI Error baseline rates of five sample preparation methods used to characterize RNA virus populations SO PLOS ONE LA English DT Article ID LIBRARY PREPARATION; SEQUENCING DATA; QUALITY-CONTROL; EBOLA-VIRUS; GENOMES; REPLICATION; VARIANTS; COLI AB Individual RNA viruses typically occur as populations of genomes that differ slightly from each other due to mutations introduced by the error-prone viral polymerase. Understanding the variability of RNA virus genome populations is critical for understanding virus evolution because individual mutant genomes may gain evolutionary selective advantages and give rise to dominant sub populations, possibly even leading to the emergence of viruses resistant to medical countermeasures. Reverse transcription of virus genome populations followed by next-generation sequencing is the only available method to characterize variation for RNA viruses. However, both steps may lead to the introduction of artificial mutations, thereby skewing the data. To better understand how such errors are introduced during sample preparation, we determined and compared error baseline rates of five different sample preparation methods by analyzing in vitro transcribed Ebola virus RNA from an artificial plasmid-based system. These methods included: shotgun sequencing from plasmid DNA or in vitro transcribed RNA as a basic "no amplification" method, amplicon sequencing from the plasmid DNA or in vitro transcribed RNA as a "targeted" amplification method, sequenceindependent single-primer amplification (SISPA) as a "random" amplification method, rolling circle reverse transcription sequencing (CirSeq) as an advanced "no amplification" method, and Illumina TruSeq RNA Access as a "targeted" enrichment method. The measured error frequencies indicate that RNA Access offers the best tradeoff between sensitivity and sample preparation error (1.4(-5)) of all compared methods. C1 [Kugelman, Jeffrey R.; Wiley, Michael R.; Nagle, Elyse R.; Reyes, Daniel; Pfeffer, Brad P.; Sanchez-Lockhart, Mariano; Palacios, Gustavo F.] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA. [Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick IRF Frederick, NIH, Frederick, MD USA. RP Palacios, GF (reprint author), US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA. EM gustavo.f.palacios.ctr@mail.mil FU Defense Threat Reduction Agency; Battelle Memorial Institute's prime; US National Institute of Allergy and Infectious Diseases (NIAID) [HHSN272200700016I]; Tunnell Government Services, Inc. FX This work was supported by Defense Threat Reduction Agency and Battelle Memorial Institute's prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID)under Contract No. HHSN272200700016I (J.H.K.). A subcontractor to Battelle Memorial Institute who performed this work is : J.H.K., an employee of Tunnell Government Services, Inc. NR 34 TC 0 Z9 0 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 9 PY 2017 VL 12 IS 2 AR e0171333 DI 10.1371/journal.pone.0171333 PG 13 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EK9GJ UT WOS:000394231800055 PM 28182717 ER PT J AU Pichyangkul, S Spring, MD Yongvanitchit, K Kum-Arb, U Limsalakpetch, A Im-Erbsin, R Ubalee, R Vanachayangkul, P Remarque, EJ Angov, E Smith, PL Saunders, DL AF Pichyangkul, Sathit Spring, Michele D. Yongvanitchit, Kosol Kum-Arb, Utaiwan Limsalakpetch, Amporn Im-Erbsin, Rawiwan Ubalee, Ratawan Vanachayangkul, Pattaraporn Remarque, Edmond J. Angov, Evelina Smith, Philip L. Saunders, David L. TI Chemoprophylaxis with sporozoite immunization in P-knowlesi rhesus monkeys confers protection and elicits sporozoite-specific memory T cells in the liver SO PLOS ONE LA English DT Article ID PLASMODIUM-KNOWLESI; MALARIA PARASITE; BONE-MARROW; IMMUNE-RESPONSE; INFECTION; VACCINE; STAGE; LYMPHOCYTES; CHALLENGE; BERGHEI AB Whole malaria sporozoite vaccine regimens are promising new strategies, and some candidates have demonstrated high rates of durable clinical protection associated with memory T cell responses. Little is known about the anatomical distribution of memory T cells following whole sporozoite vaccines, and immunization of nonhuman primates can be used as a relevant model for humans. We conducted a chemoprophylaxis with sporozoite (CPS) immunization in P. knowlesi rhesus monkeys and challenged via mosquito bites. Half of CPS immunized animals developed complete protection, with a marked delay in parasitemia demonstrated in the other half. Antibody responses to whole sporozoites, CSP, and AMA1, but not CelTOS were detected. Peripheral blood T cell responses to whole sporozoites, but not CSP and AMA1 peptides were observed. Unlike peripheral blood, there was a high frequency of sporozoite-specific memory T cells observed in the liver and bone marrow. Interestingly, sporozoite-specific CD4(+) and CD8(+) memory T cells in the liver highly expressed chemokine receptors CCR5 and CXCR6, both of which are known for liver sinusoid homing. The majority of liver sporozoite-specific memory T cells expressed CD69, a phenotypic marker of tissue-resident memory (T-RM) cells, which are well positioned to rapidly control liver-stage infection. Vaccine strategies that aim to elicit large number of liver TRM cells may efficiently increase the efficacy and durability of response against pre-erythrocytic parasites. C1 [Pichyangkul, Sathit; Spring, Michele D.; Yongvanitchit, Kosol; Kum-Arb, Utaiwan; Limsalakpetch, Amporn; Im-Erbsin, Rawiwan; Ubalee, Ratawan; Vanachayangkul, Pattaraporn; Smith, Philip L.; Saunders, David L.] AFRIMS, Bangkok, Thailand. [Remarque, Edmond J.] Biomed Primate Res Ctr, Rijswijk, Netherlands. [Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Pichyangkul, S (reprint author), AFRIMS, Bangkok, Thailand. EM sathitp@afrims.org FU Military Infectious Diseases Research Program (MIDRP), Fort Detrick, Maryland, United States of America FX This work was supported by the Military Infectious Diseases Research Program (MIDRP), Fort Detrick, Maryland, United States of America. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 54 TC 0 Z9 0 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 9 PY 2017 VL 12 IS 2 AR e0171826 DI 10.1371/journal.pone.0171826 PG 20 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EK9GJ UT WOS:000394231800122 PM 28182750 ER PT J AU Blais, EM Rawls, KD Dougherty, BV Li, ZI Kolling, GL Ye, P Wallqvist, A Papin, JA AF Blais, Edik M. Rawls, Kristopher D. Dougherty, Bonnie V. Li, Zhuo I. Kolling, Glynis L. Ye, Ping Wallqvist, Anders Papin, Jason A. TI Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions SO NATURE COMMUNICATIONS LA English DT Article ID GLOBAL RECONSTRUCTION; CULTURED-HEPATOCYTES; ESCHERICHIA-COLI; LIVER-MICROSOMES; LITHOCHOLIC ACID; CLINICAL-DATA; DRUG TARGETS; AMINO-ACID; EVOLUTION; MODELS AB The laboratory rat has been used as a surrogate to study human biology for more than a century. Here we present the first genome-scale network reconstruction of Rattus norvegicus metabolism, iRno, and a significantly improved reconstruction of human metabolism, iHsa. These curated models comprehensively capture metabolic features known to distinguish rats from humans including vitamin C and bile acid synthesis pathways. After reconciling network differences between iRno and iHsa, we integrate toxicogenomics data from rat and human hepatocytes, to generate biomarker predictions in response to 76 drugs. We validate comparative predictions for xanthine derivatives with new experimental data and literature-based evidence delineating metabolite biomarkers unique to humans. Our results provide mechanistic insights into species-specific metabolism and facilitate the selection of biomarkers consistent with rat and human biology. These models can serve as powerful computational platforms for contextualizing experimental data and making functional predictions for clinical and basic science applications. C1 [Blais, Edik M.; Rawls, Kristopher D.; Dougherty, Bonnie V.; Li, Zhuo I.; Papin, Jason A.] Univ Virginia, Dept Biomed Engn, Box 800759,Hlth Syst, Charlottesville, VA 22908 USA. [Kolling, Glynis L.] Univ Virginia, Dept Med, Div Infect Dis & Int Hlth, Charlottesville, VA 22908 USA. [Ye, Ping; Wallqvist, Anders] US Army, Telemed & Adv Technol Res Ctr, High Performance Comp Software Applicat Inst, Dept Def Biotechnol,Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Ye, Ping] Avera Canc Inst, Dept Mol & Expt Med, Sioux Falls, SD 57105 USA. RP Papin, JA (reprint author), Univ Virginia, Dept Biomed Engn, Box 800759,Hlth Syst, Charlottesville, VA 22908 USA. EM papin@virginia.edu OI Rawls, Kristopher/0000-0001-5873-0127 FU United States Department of Defense [W81XWH-14-C-0054] FX We thank Michael Carter for network annotations and Jennifer A. Bartell, Arvind K. Chavali and Kevin M. D'Auria for discussions. Support for this project was provided by the United States Department of Defense (W81XWH-14-C-0054 to J.A.P.). The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or of the US Department of Defense. Citations of commercial organizations or trade names in this report do not constitute an official Department of the Army endorsement or approval of the products or services of these organizations. This paper has been approved for public release with unlimited distribution. NR 70 TC 0 Z9 0 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD FEB 8 PY 2017 VL 8 AR 14250 DI 10.1038/ncomms14250 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EJ8ZW UT WOS:000393517000001 PM 28176778 ER PT J AU Watson, NE Bahaghighat, HD Cui, K Synovec, RE AF Watson, Nathanial E. Bahaghighat, H. Daniel Cui, Ke Synovec, Robert E. TI Comprehensive Three-Dimensional Gas Chromatography with Time-of-Flight Mass Spectrometry SO ANALYTICAL CHEMISTRY LA English DT Article ID PEAK-CAPACITY SEPARATIONS; 2-DIMENSIONAL SEPARATIONS; IONIC LIQUIDS; CHEMOMETRIC ANALYSIS; STATIONARY PHASES; MODULATION RATIO; COLUMN; 1ST-DIMENSION; OPTIMIZATION AB Development of comprehensive, three-dimensional (3D) gas chromatography with time-of-flight mass spectrometric detection (GC(3)/TOFMS) is described. This instrument provides four dimensions (4D) of chemical selectivity and includes significant improvements to total selectivity (mass spectrometric and chromatographic), peak identification, and operational temperature range relative to previous models of the GC(3) reported. The new instrumental design and data output are evaluated and illustrated via two samples, a 115-component test mixture and a diesel fuel spiked with several compounds, for the purpose of illustrating the chemical selectivity benefits of this instrumental platform. Useful approaches to visualize the 4D data are presented. The GC3/TOFMS instrument experimentally achieved total peak capacity, nom ranging from 5000 to 9600 ((x) over bar = 7000, s = 1700) for 10 representative analytes for 50 min separations with component dimensional peak capacities averaging 406, 3.6, and 4.9 for D-1, D-2, and 3D, respectively. Particularly, GC3/TOFMS achieved a combined 2(D) x D-3 peak capacity ranging from 10 to 26 ((x) over bar = 17.6, s = 5.0), which is similar to what is achieved by D-2 alone in a GC x GC operating at equivalent modulation period conditions. The analytical benefits of employing three varied chemical selectivities in the D-3 separation coupled with TOFMS are illustrated through the separation and detection of 1,6-dichlorohexane and cyclohexyl isothiocyanate as part of the diesel fuel analysis. C1 [Watson, Nathanial E.; Bahaghighat, H. Daniel; Cui, Ke; Synovec, Robert E.] Univ Washington, Dept Chem, Box 351700, Seattle, WA 98195 USA. [Watson, Nathanial E.; Bahaghighat, H. Daniel] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Synovec, RE (reprint author), Univ Washington, Dept Chem, Box 351700, Seattle, WA 98195 USA. EM synovec@chem.washington.edu NR 37 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD FEB 7 PY 2017 VL 89 IS 3 BP 1793 EP 1800 DI 10.1021/acs.analchem.6b04112 PG 8 WC Chemistry, Analytical SC Chemistry GA EK2DQ UT WOS:000393738300055 PM 28208275 ER PT J AU Ciezak-Jenkins, JA Jenkins, TA AF Ciezak-Jenkins, Jennifer A. Jenkins, Timothy A. TI Shear induced weakening of the hydrogen bonding lattice of the energetic material 5,5 '-Hydrazinebistetrazole at high-pressure SO JOURNAL OF MOLECULAR STRUCTURE LA English DT Article DE High-pressure; Diamond anvil cell; Energetic materials; Vibrational spectroscopy ID HOT-SPOT FORMATION; RAMAN-SPECTROSCOPY; THERMAL-DECOMPOSITION; SINGLE-CRYSTALS; AMMONIUM AZIDE; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; EXPLOSIVES; SOLIDS; RDX AB 5,5'-Hydrazinebistetrazole (HBTA) has been studied by in-situ x-ray diffraction and vibrational spectroscopy to pressures near 25 GPa at room temperature. Analysis of the x-ray diffraction pattern of HBTA collected at ambient pressure and temperature revealed a monoclinic structure consistent with that previously reported. Under compression, the x-ray diffraction reveals little evidence of a phase transition over the pressure range studied. Slight anisotropy in response to compression was noted and the beta angle decreased moderately, suggesting geometry modifications occur in the hydrogen bonding lattice and between neighboring HBTA molecules as a result of compression along the c axis. Blue shifts in the Infrared active N-H stretching modes were observed, implying a weakening of the hydrogen bond with compression. The weakening of the hydrogen bonding lattice with pressure may lead to an increase in the bending angle of the C-N = N-C bridge between the tetrazole rings and an increased overlap between the pi-bonding orbitals. The Raman spectra showed a number of modes associated with H-N = N-H motions of the bridge become more prominent in the spectra under compression. Additionally, the possibility that the increased bend in the angle of the C-N = N-C bridge results from a shearing deformation is discussed. Published by Elsevier B.V. C1 [Ciezak-Jenkins, Jennifer A.; Jenkins, Timothy A.] US Army Res Lab, RDRL WML B Bldg 390, Aberdeen Proving Ground, MD 21005 USA. RP Ciezak-Jenkins, JA (reprint author), US Army Res Lab, RDRL WML B Bldg 390, Aberdeen Proving Ground, MD 21005 USA. EM jennifer.a.ciezak-jenkins.civ@mail.mil FU US Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886]; U.S. Department of Energy [DE-AC02-05CH11231] FX Use of the National Synchrotron Light Source, Brookhaven National Laboratory, was supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract no. DE-AC02-98CH10886. The Advanced Light Source is supported by the Director, Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. NR 29 TC 0 Z9 0 U1 23 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-2860 EI 1872-8014 J9 J MOL STRUCT JI J. Mol. Struct. PD FEB 5 PY 2017 VL 1129 BP 313 EP 318 DI 10.1016/j.molstruc.2016.09.084 PG 6 WC Chemistry, Physical SC Chemistry GA EE7HB UT WOS:000389785400038 ER PT J AU Rello, J Krenn, CG Locker, G Pilger, E Madl, C Balica, L Dugernier, T Laterre, PF Spapen, H Depuydt, P Vincent, JL Bogar, L Szabo, Z Volgyes, B Manez, R Cakar, N Ramazanoglu, A Topeli, A Mastruzzo, MA Jasovich, A Remolif, CG Soria, LD Hernandez, MAA Balart, CR Kremer, I Molnar, Z von Sonnenburg, F Lyons, A Joannidis, M Burgmann, H Welte, T Klingler, A Hochreiter, R Westritschnig, K AF Rello, Jordi Krenn, Claus-Georg Locker, Gottfried Pilger, Ernst Madl, Christian Balica, Laura Dugernier, Thierry Laterre, Pierre-Francois Spapen, Herbert Depuydt, Pieter Vincent, Jean-Louis Bogar, Lajos Szabo, Zsuzsanna Volgyes, Barbara Manez, Rafael Cakar, Nahit Ramazanoglu, Atilla Topeli, Arzu Mastruzzo, Maria A. Jasovich, Abel Remolif, Christian G. del Carmen Soria, Liliana Andresen Hernandez, Max A. Ruiz Balart, Carolina Kremer, Ildiko Molnar, Zsolt von Sonnenburg, Frank Lyons, Arthur Joannidis, Michael Burgmann, Heinz Welte, Tobias Klingler, Anton Hochreiter, Romana Westritschnig, Kerstin TI A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients SO CRITICAL CARE LA English DT Article DE Pseudomonas aeruginosa; Vaccination; Immunity; Immunocompromised host; Bacterial infections; Mortality ID PROTEIN-F; HUMAN VOLUNTEERS; OPRF-OPRI; AERUGINOSA; IMMUNOGENICITY; SAFETY; INFECTION; PNEUMONIA AB Background: Currently, no vaccine against Pseudomonas is available. IC43 is a new, recombinant, protein (OprF/I)-based vaccine against the opportunistic pathogen, Pseudomonas aeruginosa, a major cause of serious hospital-acquired infections. IC43 has proven immunogenicity and tolerability in healthy volunteers, patients with burns, and patients with chronic lung diseases. In order to assess the immunogenicity and safety of IC43 in patients who are most at risk of acquiring Pseudomonas infections, it was evaluated in mechanically ventilated ICU patients. Methods: We conducted a randomized, placebo-controlled, partially blinded study in mechanically ventilated ICU patients. The immunogenicity of IC43 at day 14 was determined as the primary endpoint, and safety, efficacy against P. aeruginosa infections, and all-cause mortality were evaluated as secondary endpoints. Vaccinations (100 mu g or 200 mu g IC43 with adjuvant, or 100 mu g IC43 without adjuvant, or placebo) were given twice in a 7-day interval and patients were followed up for 90 days. Results: Higher OprF/I IgG antibody titers were seen at day 14 for all IC43 groups versus placebo (P < 0.0001). Seroconversion (>= 4-fold increase in OprF/I IgG titer from days 0 to 14) was highest with 100 mu g IC43 without adjuvant (80.6%). There were no significant differences in P. aeruginosa infection rates, with a low rate of invasive infections (pneumonia or bacteremia) in the IC43 groups (11.2-14.0%). Serious adverse events (SAEs) considered possibly related to therapy were reported by 2 patients (1.9%) in the group of 100 mu g IC43 with adjuvant. Both SAEs resolved and no deaths were related to study treatment. Local tolerability symptoms were mild and rare (<5% of patients), a low rate of treatment-related treatment-emergent adverse events (3.1-10.6%) was observed in the IC43 groups. Conclusion: This phase II study has shown that IC43 vaccination of ventilated ICU patients produced a significant immunogenic effect. P. aeruginosa infection rates did not differ significantly between groups. In the absence of any difference in immune response following administration of 100 mu g IC43 without adjuvant compared with 200 mu g IC43 with adjuvant, the 100 mu g dose without adjuvant was considered for further testing of its possible benefit of improved outcomes. There were no safety or mortality concerns. C1 [Rello, Jordi] Hosp Univ Joan XXIII, C Dr Mallafre Guasch 4, Tarragona 43007, Spain. [Rello, Jordi] Hosp Univ Vall dHebron, CIBERES, Passeig Vall dHebron 119, Barcelona 08035, Spain. [Krenn, Claus-Georg] Med Univ Vienna, Intens Care 13C1, Wahringer Gurtel 18-20, A-1090 Vienna, Austria. [Locker, Gottfried] Med Univ Vienna, Dept Internal Med 1, Intens Care 13I2, Wahringer Gurtel 18-20, A-1090 Vienna, Austria. [Pilger, Ernst] Univ Hosp Graz, Intens Care, Dept Internal Med, Auenbruggerpl 15, A-8036 Graz, Austria. [Madl, Christian] Med Univ Vienna, Dept Internal Med 3, Intens Care 13H1, Wahringer Gurtel 18-20, A-1090 Vienna, Austria. [Balica, Laura] Emergency Clin Hosp Bucharest, Toxicol ICU, 8 Floreasca St, Bucharest 01446, Romania. [Dugernier, Thierry] Clin St Pierre, Dept Intens Care, Ave Reine Fabiola 9, B-1340 Ottignies, Belgium. [Laterre, Pierre-Francois] Catholic Univ Louvain, Dept CCM, St Luc Univ Hosp UCL, Ave Hippocrate 10, B-1200 Brussels, Belgium. [Spapen, Herbert] Vrije Univ Brussels, Univ Hosp, Laarbeeklaan 101, B-1090 Brussels, Belgium. [Depuydt, Pieter] UZ Gent, De Pintelaan 185, B-9000 Ghent, Belgium. [Vincent, Jean-Louis] Univ Libre Bruxelles, Erasme Univ Hosp, Route Lennik 808, B-1070 Brussels, Belgium. [Bogar, Lajos] Univ Pecs, Anesthesiol & Intens Care Dept, Ifjusag Ut 13, H-7624 Pecs, Hungary. [Szabo, Zsuzsanna] Uzsoki Hosp, Uzsoki U 29, H-1145 Budapest, Hungary. [Volgyes, Barbara] Bajcsy Zsilinszky Hosp & Polyclin, Intens Care Unit, Maglodi Ut 89-91, H-1106 Budapest, Hungary. [Manez, Rafael] Bellvitge Univ Hosp, Dept Crit Care Med, Feixa Llarga S-N, Barcelona 08907, Spain. [Cakar, Nahit] Istanbul Univ, Capa Med Fac, Dept Anesthesiol & Reanimat, TR-34390 Istanbul, Turkey. [Ramazanoglu, Atilla] Akdeniz Univ, Dept Anesthesiol, Fac Med Hosp, Dumlupinar Bulvari Kampus Antalya, TR-07070 Antalya, Turkey. [Topeli, Arzu] Hacettepe Univ Hosp, Intens Care Unit, Dept Internal Med, TR-06100 Ankara, Turkey. [Mastruzzo, Maria A.] Hosp Dr Carlos Bocalandro, Ruta 8 9100,B1657BHD Loma Hermosa, Buenos Aires, DF, Argentina. [Jasovich, Abel] Sanatorio Guemes Hosp Privado, Ave Roque Sanchez Pena 811 5 C,C1035AAP, Buenos Aires, DF, Argentina. [Remolif, Christian G.] Hosp Heroes Malvinas, Ave Ricardo Balbin 1910,B1721FJN, Buenos Aires, DF, Argentina. [del Carmen Soria, Liliana] Hosp Cent Mendoza, Alem & Salta M5500GKO, Mendoza, Argentina. [Andresen Hernandez, Max A.] Univ Catolica Chile, Fac Med Pontificia, Hosp Clin, Marcoleta 367, Santiago, Chile. [Ruiz Balart, Carolina] Pontificia Univ Catolica Chile, Hosp Dr Sotero del Rio, Unidad Cuidado Intens, Dept Med Intens,Escuela Med, Ave Concha & Toro 3459, Santiago, Chile. [Kremer, Ildiko] Flor Ferenc Cty Hosp, Semmelweis Ter 1, H-2143 Kistarcsa, Hungary. [Molnar, Zsolt] Univ Szeged, Dept Anaesthesia & Intens Care, Semmelweis U 6, H-6720 Szeged, Hungary. [von Sonnenburg, Frank] Univ Munich, Dept Infect Dis & Trop Med, Georgenstr 5, D-80799 Munich, Germany. [Lyons, Arthur] Walter Reed Army Inst Res, Dept Clin Res, Div Virus Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Joannidis, Michael] Med Univ Innsbruck, Dept Internal Med, Div Intens Care & Emergency Med, Anichstr 35, A-6020 Innsbruck, Austria. [Burgmann, Heinz] Med Univ Vienna, Dept Internal Med 1, Div Infect Dis, Wahringer Gurtek 18-20, A-1090 Vienna, Austria. [Welte, Tobias] Hannover Med Sch, Dept Resp Med, Carl Neuberg Str 1, D-30625 Hannover, Germany. [Klingler, Anton] Assign Data Management & Biostat GmbH, Stadlweg, A-6020 Innsbruck, Austria. [Hochreiter, Romana; Westritschnig, Kerstin] Valneva Austria GmbH, Campus Vienna Bioctr 3, A-1030 Vienna, Austria. [Rello, Jordi] Univ Autonoma Barcelona, Barcelona, Spain. RP Rello, J (reprint author), Hosp Univ Joan XXIII, C Dr Mallafre Guasch 4, Tarragona 43007, Spain.; Rello, J (reprint author), Hosp Univ Vall dHebron, CIBERES, Passeig Vall dHebron 119, Barcelona 08035, Spain. EM jrello@crips.es FU Valneva Austria GmbH FX This research was fully financed by Valneva Austria GmbH. NR 25 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1466-609X EI 1364-8535 J9 CRIT CARE JI Crit. Care PD FEB 4 PY 2017 VL 21 AR 22 DI 10.1186/s13054-017-1601-9 PG 13 WC Critical Care Medicine SC General & Internal Medicine GA EK3KC UT WOS:000393824200001 PM 28159015 ER PT J AU Kleifges, K Bigdely-Shamlo, N Kerick, SE Robbins, KA AF Kleifges, Kelly Bigdely-Shamlo, Nima Kerick, Scott E. Robbins, Kay A. TI BLINKER: Automated Extraction of Ocular Indices from EEG Enabling Large-Scale Analysis SO FRONTIERS IN NEUROSCIENCE LA English DT Article DE eye blinks; blink duration; EEG; artifact; EEGLAB; machine learning; big data; human behavior ID INDEPENDENT COMPONENT ANALYSIS; SPONTANEOUS EYEBLINK ACTIVITY; BRAIN-COMPUTER INTERFACE; EYE-BLINKS; INDIVIDUAL-DIFFERENCES; DRIVING PERFORMANCE; SLEEPINESS; DROWSINESS; DYNAMICS; TASK AB Electroencephalography (EEG) offers a platform for studying the relationships between behavioral measures, such as blink rate and duration, with neural correlates of fatigue and attention, such as theta and alpha band power. Further, the existence of EEG studies covering a variety of subjects and tasks provides opportunities for the community to better characterize variability of these measures across tasks and subjects. We have implemented an automated pipeline (BLINKER) for extracting ocular indices such as blink rate, blink duration, and blink velocity-amplitude ratios from EEG channels, FOG channels, and/or independent components (ICs). To illustrate the use of our approach, we have applied the pipeline to a large corpus of EEG data (comprising more than 2000 datasets acquired at eight different laboratories) in order to characterize variability of certain ocular indicators across subjects. We also investigate dependence of ocular indices on task in a shooter study. We have implemented our algorithms in a freely available MATLAB toolbox called BLINKER. The toolbox, which is easy to use and can be applied to collections of data without user intervention, can automatically discover which channels or ICs capture blinks. The tools extract blinks, calculate common ocular indices, generate a report for each dataset, dump labeled images of the individual blinks, and provide summary statistics across collections. Users can run BLINKER as a script or as a plugin for EEGLAB. The toolbox is available at https://github.comNisLab/EEG-Blinks. User documentation and examples appear at http://vislab.github.io/EEG-Blinks/. C1 [Kleifges, Kelly; Robbins, Kay A.] Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA. [Bigdely-Shamlo, Nima] Qusp, Qusp Labs, San Diego, CA USA. [Kerick, Scott E.] US Army, Res Lab, Aberdeen, MD USA. RP Robbins, KA (reprint author), Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA. EM Kay.Robbins@utsa.edu FU Army Research Laboratory; NIH [1R01MH084819-03] FX The authors wish to gratefully acknowledge our many collaborators on the CAN-CTA project, especially Dave Hairston and Vernon Lawhern of the Army Research Laboratory, CT Lin, Tzyy-Ping Jung, Chun-Hsiang Chuang, and Jung-Tai King of National Chiao Tung University, as well as Tony Johnson and Michael Dunkel of DCS Corporation. The research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0022 and NIH grant 1R01MH084819-03. NR 47 TC 0 Z9 0 U1 7 U2 7 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1662-453X J9 FRONT NEUROSCI-SWITZ JI Front. Neurosci. PD FEB 3 PY 2017 VL 11 AR 12 DI 10.3389/fnins.2017.00012 PG 17 WC Neurosciences SC Neurosciences & Neurology GA EJ5CI UT WOS:000393233700001 PM 28217081 ER PT J AU Borstad, GM Ciezak-Jenkins, JA AF Borstad, Gustav M. Ciezak-Jenkins, Jennifer A. TI Hydrogen-Bonding Modification in Biuret Under Pressure SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID VIBRATIONAL-SPECTRA; CRYSTAL-STRUCTURE; INFRARED-SPECTRA; UREA; NITROGEN; RAMAN; PHASE; DIFFRACTION; SCATTERING; HYDRATE AB Biuret (C2H5N3O2) has been studied to 30 GPa by Raman spectroscopy and 50 GPa by X-ray diffraction. Raman peaks exhibit shoulders and splitting that suggests that the molecules undergo reorientation in response to compression. These are observed in three pressure ranges: the first from 3-5 GPa, the second from 8-12 GPa, and finally from 16-20 GPa. The particular modes in the sample that are observed to change in the Raman are strongly linked to the molecular vibrations involving the N-H and the C=O bond, which are most strongly coupled to the hydrogen bonded lattice structure. The X-ray diffraction suggests that the crystal maintains a monoclinic structure to the highest pressures studied. Although there was a considerable degree of hysteresis observed in some X-ray runs, all the changes observed under pressure are reversible. C1 [Borstad, Gustav M.; Ciezak-Jenkins, Jennifer A.] US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Ciezak-Jenkins, JA (reprint author), US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. EM jennifer.a.ciezak-jenkins.civ@mail.mil FU Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy [DE-AC02-05CH11231] FX During this project, coauthor G.M.B. was supported in part by an appointment to the Postdoctoral Research Program at the US Army Research Laboratory administered by the Oak Ridge Associated Universities. Portions of this work were performed at the Advanced Light Source, which is supported by the Director, Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. NR 39 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD FEB 2 PY 2017 VL 121 IS 4 BP 762 EP 770 DI 10.1021/acs.jpca.6b09670 PG 9 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA EJ7ZW UT WOS:000393443000003 PM 28056500 ER PT J AU Chapman, N Borodin, O Yoon, T Nguyen, CC Lucht, BL AF Chapman, Navid Borodin, Oleg Yoon, Taeho Cao Cuong Nguyen Lucht, Brett L. TI Spectroscopic and Density Functional Theory Characterization of Common Lithium Salt Solvates in Carbonate Electrolytes for Lithium Batteries SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; POLARIZABLE FORCE-FIELDS; PROPYLENE CARBONATE; ETHYLENE CARBONATE; IONIC ASSOCIATION; AB-INITIO; LIQUID ELECTROLYTES; MIXED-SOLVENT; FREE-ENERGY; LI+ AB The structure and composition of lithium ion solvation spheres of electrolyte solutions composed of common lithium salts (LiTFSI, LiPF6, LiBF4, and LiClO4) dissolved in aprotic polar linear and cyclic carbonate solvents (propylene carbonate (PC) or dimethyl carbonate (DMC)) have been investigated via a combination of FTIR, C-13 NMR spectroscopy, and density functional theory (DFT). Results from the two different spectroscopic methods are in strong agreement with each other and with predictions from quantum chemistry calculations. The coordination of the carbonyl oxygen of the solvents to the lithium cation is observed by IR spectroscopy. The ratio of coordinated to uncoordinated PC and DMC has been used to determine solvent coordination numbers which range from 2 to 5 depending on salt, solvent, and concentration. The relative stability of the lithium anion solvates were examined using DFT employing the cluster-continuum approach including changes to the intensity and frequency of the IR bands along with the populations of the cis-cis and cis - trans conformers of DMC in the lithium ion solvation shell. Solvent coordination is dependent upon the nature of the salt. Weakly associating salts, LiTFSI, LiPF6, and LiCIO4, dissociate to a similar degree with LiPF6 being the most dissociated, while LiBF4 had significantly less dissociation in both solvents. This investigation provides significant insight into the solution structure of commonly used LIB electrolytes over a wide range of salt concentrations. C1 [Chapman, Navid; Yoon, Taeho; Cao Cuong Nguyen; Lucht, Brett L.] Univ Rhode Isl, Dept Chem, Kingston, RI 02881 USA. [Borodin, Oleg] US Army, Power & Energy Div, Electrochem Branch Sensor & Electron Devices Dire, Res Lab, Adelphi, MD 20783 USA. RP Lucht, BL (reprint author), Univ Rhode Isl, Dept Chem, Kingston, RI 02881 USA. EM blucht@chm.uri.edu OI Yoon, Taeho/0000-0002-9403-9250 FU Department of Energy Office of Basic Energy Sciences EPSCoR Implementation award [DE-SC0007074] FX The authors gratefully acknowledge funding from Department of Energy Office of Basic Energy Sciences EPSCoR Implementation award (DE-SC0007074) NR 76 TC 0 Z9 0 U1 10 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD FEB 2 PY 2017 VL 121 IS 4 BP 2135 EP 2148 DI 10.1021/acs.jpcc.6b12234 PG 14 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA EJ7ZY UT WOS:000393443200013 ER PT J AU Ding, MS von Cresce, A Xu, K AF Ding, Michael S. von Cresce, Arthur Xu, Kang TI Conductivity, Viscosity, and Their Correlation of a Super Concentrated Aqueous Electrolyte SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID PC-EC SOLUTIONS; PROPYLENE CARBONATE; SOLVENT COMPOSITION; METHYL CARBONATE; SALT CONTENT; WATER; TEMPERATURE; LIPF6; DEC; CONDUCTANCE AB A super-concentrated aqueous electrolyte, "water-in-bisalt (WiBS)", consisting of 21 m lithium bis(trifluoromethanesulfonyl)imide and 7 m lithium trifluoromethanesulfonate on the most concentrated end, was measured for its electrolytic conductivity k and glass transition temperature T-g in wide ranges of salt concentration m and temperature 0, with Tg as an indicator for the electrolyte viscosity. The measured K-(m, theta) data in its entirety was fitted with an extended Casteel-Amis equation for an accurate functional representation, and the k-theta data for the most concentrated electrolytes were fitted with the Vogel-Fulcher-Tammann equation for an evaluation of the activation energy Ea and vanishing mobility temperature To. The resultant values of K. and T-0 are compared and correlated with T-g, and the possibility of the formation of a water salt liquid structure under these super-concentrated environments is discussed. C1 [Ding, Michael S.; von Cresce, Arthur; Xu, Kang] US Army, Res Lab, Adelphi, MD 20783 USA. RP Ding, MS (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM michael.s.ding.civ@mail.mil FU U.S. Army Research Laboratory FX Funding from U.S. Army Research Laboratory is gratefully acknowledged. NR 23 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD FEB 2 PY 2017 VL 121 IS 4 BP 2149 EP 2153 DI 10.1021/acs.jpcc.6b12636 PG 5 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA EJ7ZY UT WOS:000393443200014 ER PT J AU Gao, Z Charles, RD Li, XL AF Gao, Zheng Charles, Richard D. Li, Xiaolin TI Numerical Modeling of Flow Through Porous Fabric Surface in Parachute Simulation SO AIAA JOURNAL LA English DT Article ID IMMERSED BOUNDARY METHOD; NAVIER-STOKES EQUATIONS; FRONT TRACKING; INTERFACE TRACKING; INFLATION; VERIFICATION C1 [Gao, Zheng; Li, Xiaolin] SUNY Stony Brook, Appl Math & Stat, Stony Brook, NY 11794 USA. [Charles, Richard D.] US Army, Natick Res Dev & Engn Ctr, Airdrop Technol Team, Natick, MA 01760 USA. RP Gao, Z (reprint author), SUNY Stony Brook, Appl Math & Stat, Stony Brook, NY 11794 USA. FU U.S. Army Research Office [W911NF1410428]; ARODURIP Grant [W911NF-15-1-0403]; Oak Ridge National Laboratory through the High Education Research Experience program FX This work is currently supported in part by the U.S. Army Research Office under the award W911NF1410428 and the ARODURIP Grant W911NF-15-1-0403. The authors would like to give special thanks to Joseph Myers of the U.S. Army Research Office for fostering the collaborative relationship between authors at Stony Brook University and the Army scientist at the Army Natick Research Development and Engineering Center. The authors would like to thank Qiangqiang Shi and Yiyang Yang for helpful discussion and early work on the parachute problem. Xiaolin Li would also like to acknowledge the support by the Oak Ridge National Laboratory through the High Education Research Experience program. NR 33 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 EI 1533-385X J9 AIAA J JI AIAA J. PD FEB PY 2017 VL 55 IS 2 BP 686 EP 690 DI 10.2514/1.J054997 PG 5 WC Engineering, Aerospace SC Engineering GA EM8IR UT WOS:000395555300030 ER PT J AU Beidleman, BA Staab, JE Muza, SR Sawka, MN AF Beidleman, Beth A. Staab, Janet E. Muza, Stephen R. Sawka, Michael N. TI Quantitative model of hematologic and plasma volume responses after ascent and acclimation to moderate to high altitudes SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Letter ID ACUTE MOUNTAIN-SICKNESS; BLOOD-VOLUME; EXERCISE; EXPOSURE; HYPOXIA; MASS; METAANALYSIS; DEHYDRATION; ALDOSTERONE; ADAPTATIONS C1 [Beidleman, Beth A.; Staab, Janet E.; Muza, Stephen R.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. [Sawka, Michael N.] Georgia Inst Technol, Sch Biol Sci, Atlanta, GA 30332 USA. RP Beidleman, BA (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM beth.a.beidleman.civ@mail.mil FU U.S. Anti-Doping Agency; U.S. Army Medical Research and Materiel Command FX Funding was provided by the U.S. Anti-Doping Agency and U.S. Army Medical Research and Materiel Command. NR 45 TC 0 Z9 0 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 EI 1522-1490 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD FEB PY 2017 VL 312 IS 2 BP R265 EP R272 DI 10.1152/ajpregu.00225.2016 PG 8 WC Physiology SC Physiology GA EN0RP UT WOS:000395717500013 PM 28039191 ER PT J AU Krauss, MR Garvin, NU Boivin, MR Cowan, DN AF Krauss, Margot R. Garvin, Nadia U. Boivin, Michael R. Cowan, David N. TI Excess Stress Fractures, Musculoskeletal Injuries, and Health Care Utilization Among Unfit and Overweight Female Army Trainees SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE fitness; body fat; musculoskeletal injury; military; health care utilization ID BODY-MASS INDEX; PHYSICAL-FITNESS; RISK-FACTORS; RECRUITS; OBESITY; MOTIVATION; MEN AB Background: Musculoskeletal injuries are prevalent among military trainees and certain occupations. Fitness and body mass index (BMI) have been associated with musculoskeletal conditions, including stress fractures. Hypothesis: The incidence of, and excess health care utilization for, stress fracture and non-stress fracture overuse musculoskeletal injuries during the first 6 months of service is higher among unfit female recruits. Those who exceeded body fat limits are at a greater risk of incident stress fractures, injuries, or health care utilization compared with weight-qualified recruits. Study Design: Cohort study; Level of evidence, 3. Methods: All applicants to the United States Army were required to take a preaccession fitness test during the study period (February 2005-September 2006). The test included a 5-minute step test scored as pass or fail. BMI was recorded at application. There were 2 distinct comparisons made in this study: (1) between weight-qualified physically fit and unfit women and (2) between weight-qualified physically fit women and those who exceeded body fat limits. We compared the incidence of, and excess health care utilization for, musculoskeletal injuries, including stress fractures and physical therapy visits, during the first 183 days of military service. Results: Among the weight-qualified women, unfit participants had a higher non-stress fracture injury incidence and related excess health care utilization rate compared with fit women, with rate ratios of 1.32 (95% CI, 1.14-1.53) and 1.18 (95% CI, 1.10-1.27), respectively. Among fit women, compared with the weight-qualified participants, those exceeding body fat limits had higher rate ratios for non-stress fracture injury incidence and related excess health care utilization of 1.27 (95% CI, 1.07-1.50) and 1.20 (95% CI, 1.11-1.31), respectively. Weight-qualified women who were unfit had a higher incidence of stress fractures and related excess health care utilization compared with fit women, with rate ratios of 1.62 (95% CI, 1.19-2.21) and 1.22 (95% CI, 1.10-1.36), respectively. Among fit women exceeding body fat limits, the stress fracture incidence and related excess health care utilization rate ratios were 0.79 (95% CI, 0.49-1.28) and 1.44 (95% CI, 1.20-1.72), respectively, compared with those who were weight qualified. Conclusion: The results indicate a significantly increased risk of musculoskeletal injuries, including stress fractures, among unfit recruits and an increased risk of non-stress fracture musculoskeletal injuries among recruits who exceeded body fat limits. Once injured, female recruits who were weight qualified but unfit and those who were fit but exceeded body fat limits had increased health care utilization. These findings may have implications for military accession and training policies as downsizing of military services will make it more important than ever to optimize the health and performance of individual service members. C1 [Krauss, Margot R.; Garvin, Nadia U.; Boivin, Michael R.; Cowan, David N.] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Krauss, Margot R.; Garvin, Nadia U.; Cowan, David N.] ManTech Int Corp, Fairfax, VA USA. RP Cowan, DN (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM david.n.cowan.ctr@mail.mil FU US Army Medical Research and Materiel Command; ManTech International Corporation FX One or more of the authors has declared the following potential conflict of interest or source of funding: This study was funded by the US Army Medical Research and Materiel Command with ManTech International Corporation. NR 20 TC 1 Z9 1 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 EI 1552-3365 J9 AM J SPORT MED JI Am. J. Sports Med. PD FEB PY 2017 VL 45 IS 2 BP 311 EP 316 DI 10.1177/0363546516675862 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA EL7BU UT WOS:000394776900006 PM 27881384 ER PT J AU Tucker, CR Strickland, JT Delaney, DK Ligon, DB AF Tucker, Charles R. Strickland, Jeramie T. Delaney, David K. Ligon, Day B. TI Thermal consequences of subterranean nesting behavior in a prairie-dwelling turtle, the Ornate Box Turtle (Terrapene ornata) SO CANADIAN JOURNAL OF ZOOLOGY LA English DT Article DE Terrapene ornata; Ornate Box Turtle; phenotypic plasticity; incubation; thermoregulation; nest-site selection ID DEPENDENT SEX DETERMINATION; HATCHLING SNAPPING TURTLES; CHELYDRA-SERPENTINA; INCUBATION-TEMPERATURE; APALONE-MUTICA; SITE SELECTION; FLUCTUATING TEMPERATURES; KINOSTERNON-FLAVESCENS; MATERNAL IDENTITY; CARETTA-CARETTA AB Many oviparous reptiles deposit eggs in excavated nest chambers, and the location and depth at which eggs are laid can affect predation risk, incubation duration, mortality rates, and hatchling phenotype. Among turtles, nest depth also influences incubation conditions of some large-bodied species, but nest depth is generally expected to vary less among small-bodied species. We monitored nesting behavior of Ornate Box Turtles (Terrapene ornata (Agassiz, 1857)) for two seasons in Illinois. We used direct observations to confirm that, among 31 nesting events, six females oviposited while beneath the substrate surface. Furthermore, comparisons of body length to nest depth indicated that five additional females likely also constructed nests while buried. Nests laid while females were underground were deeper, on average, than other nests (16.7 versus 11.2 cm), and while mean nest temperatures were similar between groups, temperature fluctuations and maximum temperatures were lower among nests that were laid while females were underground. Subterranean oviposition appears to have moderated incubation temperatures by allowing females to deposit eggs at greater depths than would be possible from the surface. This little-documented behavior may be a mechanism for this species to influence the incubation environment, which in turn may influence hatchling phenotypes. C1 [Tucker, Charles R.; Ligon, Day B.] Missouri State Univ, Dept Biol, 901 South Natl Ave, Springfield, MO 65897 USA. [Strickland, Jeramie T.] Upper Mississippi River Natl Wildlife & Fish Refu, 7071 Riverview Rd, Thomson, IL 61285 USA. [Delaney, David K.] US Army Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. [Tucker, Charles R.] Red Lake Wildlife Management Area, POB 100, Roosevelt, MN 56673 USA. RP Tucker, CR (reprint author), Missouri State Univ, Dept Biol, 901 South Natl Ave, Springfield, MO 65897 USA.; Tucker, CR (reprint author), Red Lake Wildlife Management Area, POB 100, Roosevelt, MN 56673 USA. EM crtucker2@gmail.com FU Upper Mississippi River National Wildlife and Fish Refuge; NASA-Missouri Space Consortium; Missouri State University FX We thank the Upper Mississippi River National Wildlife and Fish Refuge, NASA-Missouri Space Consortium, and Missouri State University for project funding and support. T. Radzio and E. Tomasovic assisted with erecting and maintaining radiotelemetry towers, and the Iowa State University "Turtle Camp" group assisted with capturing study animals. D. Thompson provided comments that greatly improved the quality of the manuscript. This project was made possible by a generous equipment loan from the U.S. Army Construction Engineering Research Laboratory. The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the U.S. Fish and Wildlife Service or the U.S. Army Construction Engineering Research Laboratory. NR 61 TC 0 Z9 0 U1 0 U2 0 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA SN 0008-4301 EI 1480-3283 J9 CAN J ZOOL JI Can. J. Zool. PD FEB PY 2017 VL 95 IS 2 BP 123 EP 131 DI 10.1139/cjz-2016-0143 PG 9 WC Zoology SC Zoology GA EM6VA UT WOS:000395449300007 ER PT J AU McDonald, B Rice, J Stewart, J AF McDonald, Brian Rice, Jeremy Stewart, John TI Decomposition characteristics of an elemental sulfur doped polysulfide based ramjet fuel SO COMBUSTION AND FLAME LA English DT Article DE Polysulfide; Solid fuel ramjet; Ignition; Fuel decomposition ID COMBUSTION; BORON AB The decomposition characteristics of five candidate polysulfide (LP-33) based ramjet solid fuel formulations are evaluated using thermogravimetric analysis and differential scanning calorimetry. The formulations are variants on the polymer crosslink mechanism and the doping mass fraction of elemental sulfur. Four fuel candidates are oxidatively cured and one formulation is cured with isocyanates. Post-cure, the Shore-A hardness of each sample is measured followed by TGA and DSC analysis. The objective of this research is to develop a solid fuel ramjet formulation with thermal decomposition onset temperatures lower than conventional ramjet fuels while maintaining a Shore-A hardness of at least 30. The results show that polysulfide based formulations decompose at temperatures approximately 120 C lower than hydroxyl-terminated polybutadiene based fuels. Additionally, the results demonstrate that the decomposition onset temperature, and the heat of decomposition can be further reduced with the addition of elemental sulfur. Published by Elsevier Inc. on behalf of The Combustion Institute. C1 [McDonald, Brian; Rice, Jeremy; Stewart, John] US Army RDECOM, RDMR WDP M, Weap Dev & Integrat Directorate, Redstone Arsenal, AL 35898 USA. RP McDonald, B (reprint author), US Army RDECOM, RDMR WDP M, Weap Dev & Integrat Directorate, Redstone Arsenal, AL 35898 USA. EM brian.mcdonald8@us.army.mil NR 19 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-2180 EI 1556-2921 J9 COMBUST FLAME JI Combust. Flame PD FEB PY 2017 VL 176 BP 1 EP 11 DI 10.1016/j.combustflame.2016.10.012 PG 11 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA EM7ND UT WOS:000395497700001 ER PT J AU Erol, O Powers, B Keefe, M AF Erol, Ozan Powers, Brian Keefe, Michael TI Development of a non-orthogonal macroscale material model for advanced woven fabrics based on mesoscale structure SO COMPOSITES PART B-ENGINEERING LA English DT Article DE Woven fabrics; Macroscale constitutive model; Mesoscale unit cell; Continuum mechanics; Finite elements ID SHELL FINITE-ELEMENT; KM2 SINGLE-FIBER; MECHANICAL-BEHAVIOR; BIAS-EXTENSION; ENGINEERING FABRICS; FORMING SIMULATION; CONSTITUTIVE MODEL; BALLISTIC IMPACT; BIAXIAL TENSION; COMPOSITE REINFORCEMENTS AB A macroscale non-orthogonal constitutive material model for woven fabrics based on a mesoscale unit cell is developed and implemented in an explicit finite element code. The model utilizes two important deformation mechanisms involved in woven fabrics: (1) Yarn elongation, and (2) Relative yarn rotation due to shear loads. The yarns' uniaxial tensile response is modeled using nonlinear springs within the unit cell formulation while a nonlinear rotational spring is used to define the fabric's shear stiffness. Continuum mechanics are employed to keep track of the yarn orientations at a given unit cell configuration. Material properties/parameters of the model can be easily determined from standard experimental tests. The material model is validated using uniaxial tensile, bias extension, 30 degrees off axis tension and indentation tests for two different plain weave Kevlar fabrics. The results show that the developed model is capable of the mechanical response of the woven fabrics under various loading conditions. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Erol, Ozan; Powers, Brian; Keefe, Michael] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Powers, Brian] Army Res Lab, Aberdeen Proving Ground, MD USA. [Erol, Ozan; Keefe, Michael] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. RP Erol, O (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. EM ozanerol@udel.edu NR 62 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-8368 EI 1879-1069 J9 COMPOS PART B-ENG JI Compos. Pt. B-Eng. PD FEB 1 PY 2017 VL 110 BP 497 EP 510 DI 10.1016/j.compositesb.2016.11.023 PG 14 WC Engineering, Multidisciplinary; Materials Science, Composites SC Engineering; Materials Science GA EN2LL UT WOS:000395841600048 ER PT J AU Webb, HE Rosalky, DA McAllister, MJ Acevedo, EO Kamimori, GH AF Webb, Heather E. Rosalky, Deena A. McAllister, Matthew J. Acevedo, Edmund O. Kamimori, Gary H. TI Aerobic fitness impacts sympathoadrenal axis responses to concurrent challenges SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Dual stress; Cardiorespiratory fitness; SA axis; Epinephrine; Norepinephrine; Cardiovascular reactivity ID EXERCISE PRESSOR REFLEX; PSYCHOLOGICAL STRESS; UNTRAINED MEN; CARDIORESPIRATORY RESPONSES; OXYGEN-UPTAKE; HEART-RATE; REACTIVITY; FIREFIGHTERS; CORTISOL; HUMANS AB The combination of mental and physical challenges can elicit exacerbated cardiorespiratory (CR) and catecholamine responses above that of a single challenge alone. This study examined the effects of a combination of acute mental challenges and physical stress on cardiorespiratory and catecholamine responses. Eight below-average fitness (LF VO2max = 36.58 +/- 3.36 ml(-1) kg(-1) min(-1)) and eight above-average fitness (HF VO2max = 51.18 +/- 2.09 ml(-1) kg(-1) min(-1)) participants completed an exercise-alone condition (EAC) session consisting of moderate-intensity cycling at 60% VO2max for 37 min, and a dual-challenge condition (DCC) that included concurrent participation in mental challenges while cycling. The DCC resulted in increases in perceived workload, CR, epinephrine, and norepinephrine responses overall. HF participants had greater absolute CR and catecholamine responses compared to LF participants and quicker HR recovery after the dual challenge. These findings demonstrate that cardiorespiratory fitness does impact the effect of concurrent stressors on CR and catecholamine responses. C1 [Webb, Heather E.] Texas A&M Univ Corpus Christi, Dept Kinesiol, 358 Isl Hall, Corpus Christi, TX 78412 USA. [Rosalky, Deena A.] Univ New South Wales, Sydney, NSW, Australia. [McAllister, Matthew J.] Mississippi State Univ, Starkville, MS USA. [Acevedo, Edmund O.] Virginia Commonwealth Univ, Richmond, VA USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Webb, HE (reprint author), Texas A&M Univ Corpus Christi, Dept Kinesiol, 358 Isl Hall, Corpus Christi, TX 78412 USA. EM heather.webb@tamucc.edu NR 38 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 EI 1439-6327 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD FEB PY 2017 VL 117 IS 2 BP 301 EP 313 DI 10.1007/s00421-016-3519-3 PG 13 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA EM2EZ UT WOS:000395130500008 PM 28054144 ER PT J AU Matheny, RW Carrigan, CT Abdalla, MN Geddis, AV Leandry, LA Aguilar, CA Hobbs, SS Urso, ML AF Matheny, Ronald W., Jr. Carrigan, Christopher T. Abdalla, Mary N. Geddis, Alyssa V. Leandry, Luis A. Aguilar, Carlos A. Hobbs, Stuart S. Urso, Maria L. TI RNA transcript expression of IGF-I/PI3K pathway components in regenerating skeletal muscle is sensitive to initial injury intensity SO GROWTH HORMONE & IGF RESEARCH LA English DT Article DE Skeletal muscle; Regeneration Insulin -like growth factor; PI3K; Akt; RNA ID MYOGENIC DIFFERENTIATION; PHOSPHOINOSITIDE 3-KINASES; MYOBLAST DIFFERENTIATION; TISSUE INHIBITOR; GENE-EXPRESSION; PI3K P110-ALPHA; SATELLITE CELLS; PROTEIN-KINASE; MESSENGER-RNA; GROWTH AB Objective: Skeletal muscle regeneration is a complex process involving the coordinated input from multiple stimuli. Of these processes, actions of the insulin -like growth factor-I (IGF-I) and phosphoinositide 3-Icinase (PI3K) pathways are vital; however, whether IGF-I or PI3K expression is modified during regeneration relative to initial damage intensity is unknown. The objective of this study was to determine whether mRNA expression of IGF-I/P13K pathway components was differentially regulated during muscle regeneration in mice in response to traumatic injury induced by freezing of two different durations. Design: Traumatic injury was imposed by applying a 6-mm diameter cylindrical steel probe, cooled to the temperature of dry ice (-79 degrees C), to the belly of the left tibialis anterior muscle of 12-week-old C57BL/6J mice for either 5 s (5 s) or 10 s (10 s). The right leg served as the uninjured control. RNA was obtained from injured and control muscles following 3, 7, and 21 days recovery and examined by real-time PCR. Expression of transcripts within the IGF, PIN, and Akt families, as well as for myogenic regulatory factors and micro-RNA5 were studied. Results: Three days following injury, there was significantly increased expression of Igf1, Igf2, Igf1r,lgf2r,Pik3cb, Pik3cd, Pik3cg, Pik3r1, Pik3r5, Aktl, and Akt3 in response to either 5 s or 10 s injury compared to uninjured control muscle. There was a significantly greater expression of Pik3cb, Pik3cd, Pik3cg, Pik3r5, Akt1, and Akt3 in 10 s injured muscle compared to 5 s injured muscle. Seven days following injury, we observed significantly increased expression of Igfl, Igf2, Pik3cd, and Pik3cg in injured muscle compared to control muscle in response to 10 s freeze injury. We also observed significantly reduced expression of Igflr and miR-133a in response to 5 s freeze injury compared to control muscle, and significantly reduced expression of Ckm, miR-1 and miR-133a in response to 10 s freeze injury as compared to control. Twenty-one days following injury, 5 s freeze -injured muscle exhibited significantly increased expression of Igf2, Igf2r, Pik3cg, Akt3, Myod1, Myog, Myf5, and miR-206 compared to control muscle, while 10 s freeze -injured muscles showed significantly increased expression of Igf2, Igf2r, Pik3cb, Pik3cd, Pik3r5, Akt1, Akt3, and Myog compared to control. Expression of miR-1 was significantly reduced in 10 5 freeze -injured muscle compared to control muscle at this time. There were no significant differences in RNA expression between 5 s and 10 s injury at either 7 d or 21 d recovery in any transcript examined. Conclusions: During early skeletal muscle regeneration in mice, transcript expressions for some components of the IGF-I/PI3K pathway are sensitive to initial injury intensity induced by freeze damage. Published by Elsevier Ltd. C1 [Matheny, Ronald W., Jr.; Carrigan, Christopher T.; Abdalla, Mary N.; Geddis, Alyssa V.; Leandry, Luis A.; Hobbs, Stuart S.; Urso, Maria L.] US Army, Environm Med Res Inst, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. [Aguilar, Carlos A.] MIT, Lincoln Lab, 244 Wood St, Lexington, MA 02420 USA. [Abdalla, Mary N.] Univ Massachusetts, Sch Med, Dept Mol Cell & Canc Biol, 364 Plantat St, Worcester, MA 01605 USA. [Urso, Maria L.] Biocompatibles Inc, Five Tower Bridge,Suite 810,300 Barr Harbor Dr, W Conshohocken, PA 19428 USA. RP Matheny, RW (reprint author), US Army, Environm Med Res Inst, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. EM ronald.w.matheny.civ@mail.mil FU U.S. Army Research Area directorate III; Military Research and Materiel Command; U.S. Army Research Institute of Environmental Medicine FX This work was supported by a funding from U.S. Army Research Area directorate III, Military Research and Materiel Command (to M.L.U. and R.W.M.). C.T.C., A.V.G., and M.N.A. were supported by appointments to the Postgraduate Research Participation Program at the U.S. Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through interagency agreement between the U.S. Department of Energy and U.S. Army Medical Research and Materiel Command. The authors wish to thank Dr. Earl Wogy of the Brandywine Center for Aging Studies for his helpful discussions during the preparation of this manuscript. NR 56 TC 0 Z9 0 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1096-6374 EI 1532-2238 J9 GROWTH HORM IGF RES JI Growth Horm. IGF Res. PD FEB PY 2017 VL 32 SI SI BP 14 EP 21 DI 10.1016/j.ghir.2016.09.002 PG 8 WC Cell Biology; Endocrinology & Metabolism SC Cell Biology; Endocrinology & Metabolism GA EN2LG UT WOS:000395841100003 ER PT J AU Nindl, BC Alemany, JA Rarick, KR Eagle, SR Darnell, ME Allison, KF Harman, EA AF Nindl, Bradley C. Alemany, Joseph A. Rarick, Kevin R. Eagle, Shawn R. Darnell, Mathew E. Allison, Katelyn F. Harman, Everett A. TI Differential basal and exercise-induced IGF-I system responses to resistance vs. calisthenic-based military readiness training programs SO GROWTH HORMONE & IGF RESEARCH LA English DT Article DE IGFBPs; Free IGF-I; Army; Acute resistance ID GROWTH-FACTOR-I; MAJOR PHYSIOLOGICAL REGULATOR; BODY-COMPOSITION CHANGES; PHYSICAL PERFORMANCE; BINDING-PROTEINS; SKELETAL-MUSCLE; HORMONE; FITNESS; WOMEN; MEN AB Objective: The purpose of this study was to: 1) evaluate differential responses of the IGF-I system to either a calisthenic- or resistance exercise -based program and 2) determine if this chronic training altered the IGF-I system during an acute resistance exercise protocol. Design: Thirty-two volunteers were randomly assigned into a resistance exercise -based training (RT) group (n = 15 +/- 27 5 y,174 +/- 6 cm, 81 +/- 12 kg) or a calisthenic -based training group (CT) (n = 17 +/- 29 5 y, 179 +/- 8 cm, 85 10 kg) and all underwent 8 weeks of exercise training (1.5 h/d, 5 d/wk). Basal blood was sampled pre (Week 0), mid- (Week 4) and post -training (Week 8) and assayed for IGF-I system analytes. An acute resistance exercise protocol (AREP) was conducted preand post -training consisting of 6 sets of 10 repetitions in the squat with two minutes of rest in between sets and the IGF-I system analytes measured. A repeated measures ANOVA (p <= 0.05) was used for statistical analysis. Results: No interaction or within -subject effects were observed for basal total IGF-I, free IGF-I, or IGFBP-1. IGFBP-2 (pre; 578.6 +/- 295.7 < mid; 828.6 +/- 104.2 = post; 833.7 +/- 481.2 ng/mL; p = 0.008) and Acid Labile Subunit (ALS) changed over the exercise training (pre-; 16.2 +/- 1.3 = mid-; 17.6 +/- 1.8 > post-training; 14.3 1.9 g/mL; p = 0.01). An interaction was observed for the RT group as IGFBP-3 increased from pre to mid (3462.4 +/- 216.4 vs. 3962.2 +/- 227.9 ng/mL), but was not significant at the post-training time point (3770.3 228.7 ng/mL). AREP caused all analytes except free IGF-I (40% decrease) to increase (17-27%; p = 0.001) during exercise, returning to baseline concentration into recovery. Conclusion: Post-training, bioavailable IGF-I recovered more rapidly post -exercise. 8 wks of chronic physical training resulted in increased basal IGFBP-2 and IGFBP-3, decreased ALS, increased pre-AREP free IGF-I and a more rapid free IGF-I recovery post-AREP. While total IGF-I was insensitive to chronic physical training, changes were observed with circulating IGFBPs and bioavailable IGF-I. To glean the most robust information on the effects of exercise training, studies must move beyond relying solely on total IGF-I measures and should consider IGFBPs and bioavailable IGF-I as these components of the circulating IGF-I system are essential determinants of IGF-I physiological action. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Nindl, Bradley C.; Eagle, Shawn R.; Darnell, Mathew E.; Allison, Katelyn F.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Neuromuscular Res Lab,Warrior Human Performance R, Pittsburgh, PA 15203 USA. [Nindl, Bradley C.; Alemany, Joseph A.; Rarick, Kevin R.; Harman, Everett A.] US Army, Environm Med Res Inst, Mil Performance Div, Natick, MA 17063 USA. [Alemany, Joseph A.] US Army, Publ Hlth Ctr Provis, Injury Prevent Program, Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. RP Eagle, SR (reprint author), Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Neuromuscular Res Lab,Warrior Human Performance R, Pittsburgh, PA 15203 USA. EM seagle@pitt.edu FU Task Area S: Physiological Areas of Musculoskeletal Injury Military Operational Medicine Research Program FX This study was funded by Task Area S: Physiological Areas of Musculoskeletal Injury Military Operational Medicine Research Program. NR 44 TC 0 Z9 0 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1096-6374 EI 1532-2238 J9 GROWTH HORM IGF RES JI Growth Horm. IGF Res. PD FEB PY 2017 VL 32 SI SI BP 33 EP 40 DI 10.1016/j.ghir.2016.12.001 PG 8 WC Cell Biology; Endocrinology & Metabolism SC Cell Biology; Endocrinology & Metabolism GA EN2LG UT WOS:000395841100006 ER PT J AU Labib, M Marojevic, V Reed, JH Zaghloul, AI AF Labib, Mina Marojevic, Vuk Reed, Jeffrey H. Zaghloul, Amir I. TI Enhancing the Robustness of LTE Systems: Analysis and Evolution of the Cell Selection Process SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article AB The commercial success of LTE makes it the primary standard for 4G cellular technology, and its evolution paves the path for 5G technology. Furthermore, LIE Unlicensed has been proposed recently to allow cellular network operators to off-load some of their data traffic to LTE component carriers operating in the unlicensed band. Hence, it is critical to ensure that the LTL system performs effectively even in harsh signaling environments in both licensed and unlicensed spectrum. This article analyzes the effect of different levels of RF spoofing applied to LIE. RE spoofing affects LTE devices during the initial cell selection process, where a strong nearby cell can impede access to a serving LTL network. This is a serious threat and can be caused unintentionally, in the case of dense and uncoordinated LTE deployment in unlicensed spectrum, or intentionally, where an adversary sets up a fake LTE cell in either licensed or unlicensed LTL spectrum. This article analyzes and experimentally demonstrates the severity of these threats for the evolution of LTL and proposes effective mitigation techniques to prevent denial of service. These mitigation techniques improve the cell selection process at the LTE user equipment, and are backward-compatible with existing LTL networks. We recommend that these modifications be enforced in future releases for increasing the availability and scalability of LTE. C1 [Labib, Mina; Marojevic, Vuk; Reed, Jeffrey H.; Zaghloul, Amir I.] Virginia Tech, Blacksburg, VA 24061 USA. [Zaghloul, Amir I.] US Army Res Lab, Adelphi, MD USA. RP Labib, M (reprint author), Virginia Tech, Blacksburg, VA 24061 USA. EM mlabib@vt.edu; maroje@vt.edu FU Vencore Inc.; Defense University Research Instrumentation Program (DURIP) through the Army Research Office [W911NF-14-1-0553/0554]; National Science Foundation (NSF) [CNS-1642873] FX Portions of this work are covered under U.S. Patent Application 62/156377. This work was supported in part by Vencore Inc., the Defense University Research Instrumentation Program (DURIP) contract numbers W911NF-14-1-0553/0554 through the Army Research Office, and the National Science Foundation (NSF) contract number CNS-1642873. NR 14 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 EI 1558-1896 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD FEB PY 2017 VL 55 IS 2 BP 208 EP 215 DI 10.1109/MCOM.2017.1500706CM PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA EM8QB UT WOS:000395574900032 ER PT J AU Soldovieri, F Gennarelli, G Catapano, I Liao, D Dogaru, T AF Soldovieri, Francesco Gennarelli, Gianluca Catapano, Ilaria Liao, D. Dogaru, Traian TI Forward-Looking Radar Imaging: A Comparison of Two Data Processing Strategies SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING LA English DT Article DE Computational electromagnetics; forward-looking GPR; inverse scattering ID GROUND-PENETRATING RADAR; LANDMINE DETECTION; MINE DETECTION; GPR AB This paper aims at comparing the conventional backpropagation algorithm and a microwave tomographic approach in the framework of forward-looking ground-penetrating radar imaging. The reconstruction capabilities of both methods are investigated in terms of achievable resolution limits for a sensing configuration similar to the Synchronous Impulse Reconstruction radar developed at the U.S. Army Research Laboratory. Furthermore, reconstruction results obtained by processing full-wave simulated data are shown with the goal of comparing the capability of both methods to detect buried and surface targets in scenarios emulating realistic operation conditions. C1 [Soldovieri, Francesco; Gennarelli, Gianluca; Catapano, Ilaria] Natl Res Council Italy, Inst Elect Sensing Environm, I-80124 Naples, Italy. [Liao, D.; Dogaru, Traian] US Army, Res Lab, Adelphi, MD 20783 USA. RP Soldovieri, F (reprint author), Natl Res Council Italy, Inst Elect Sensing Environm, I-80124 Naples, Italy. EM soldovieri.f@irea.cnr.it OI SOLDOVIERI, FRANCESCO/0000-0002-0377-3127 NR 17 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1939-1404 EI 2151-1535 J9 IEEE J-STARS JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens. PD FEB PY 2017 VL 10 IS 2 BP 562 EP 571 DI 10.1109/JSTARS.2016.2543840 PG 10 WC Engineering, Electrical & Electronic; Geography, Physical; Remote Sensing; Imaging Science & Photographic Technology SC Engineering; Physical Geography; Remote Sensing; Imaging Science & Photographic Technology GA EM7BO UT WOS:000395466700016 ER PT J AU King, MA Leon, LR Morse, DA Clanton, TL AF King, Michelle A. Leon, Lisa R. Morse, Deborah A. Clanton, Thomas L. TI Unique cytokine and chemokine responses to exertional heat stroke in mice SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE interleukin-6; CXCL1; granulocyte-colony-stimulating factor; exercise; hyperthermia ID TUMOR-NECROSIS-FACTOR; WHOLE-BODY HYPERTHERMIA; SKELETAL-MUSCLE; ANTIINFLAMMATORY CYTOKINE; NEUTROPHIL MOBILIZATION; REGULATORY MECHANISMS; INFLAMMATORY RESPONSE; ACUTE HEATSTROKE; ENDOCRINE ORGAN; IN-VIVO AB In heat stroke, cytokines are believed to play important roles in multiorgan dysfunction and recovery of damaged tissue. The time course of the cytokine response is well defined in passive heat stroke (PHS), but little is known about exertional heat stroke (EHS). In this study we used a recently developed mouse EHS model to measure the responses of circulating cytokines/chemokines and cytokine gene expression in muscle. A very rapid increase in circulating IL-6 was observed at maximum core temperature (T-c,T- max)that peaked at 0.5 h of recovery and disappeared by 3 h. IL-10 was not elevated at any time. This contrasts with PHS where both IL-6 and IL-10 peak at 3 h of recovery. Keratinocyte chemoattractant (KC), granulocyte-colony-stimulating factor (G-CSF), macrophage inflammatory protein (MIP)-2, MIP-1 beta, and monocyte chemoattractive factor-1 also demonstrated near peak responses at 0.5 h. Only G-CSF and KC remained elevated at 3 h. Muscle mRNA for innate immune cytokines (IL-6, IL-10, IL-1 beta, but not TNF-beta) were greatly increased in diaphragm and soleus compared with similar measurements in PHS. We hypothesized that these altered cytokine responses in EHS may be due to a lower Tc, max achieved in EHS or a lower overall heat load. However, when these variables were controlled for, they could not account for the differences between EHS and PHS. We conclude that moderate exercise, superimposed on heat exposure, alters the pattern of circulating cytokine and chemokine production and muscle cytokine expression in EHS. This response may comprise an endocrine reflex to exercise in heat that initiates survival pathways and early onset tissue repair mechanisms. NEW & NOTEWORTHY Immune modulators called cytokines are released following extreme hyperthermia leading to heat stroke. It is not known whether exercise in hyperthermia, leading to EHS, influences this response. Using a mouse model of EHS, we discovered a rapid accumulation of interleukin-6 and other cytokines involved in immune cell trafficking. This response may comprise a protective mechanism for early induction of cell survival and tissue repair pathways needed for recovery from thermal injury. C1 [King, Michelle A.; Morse, Deborah A.; Clanton, Thomas L.] Univ Florida, Coll Hlth & Human Performance, Dept Appl Physiol & Kinesiol, Gainesville, FL 32611 USA. [Leon, Lisa R.] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. RP Clanton, TL (reprint author), Univ Florida, Coll Hlth & Human Performance, Appl Physiol & Kinesiol, 100 FLG,1864 Stadium Rd, Gainesville, FL 32611 USA. EM tclanton@hhp.ufl.edu FU U.S. Army Research Institute for Environmental Medicine, Natick, MA FX This research was supported by a contract from the U.S. Army Research Institute for Environmental Medicine, Natick, MA, with supplemental support from the BK and Betty Stevens Endowment at the University of Florida (T. L. Clanton). NR 72 TC 0 Z9 0 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD FEB PY 2017 VL 122 IS 2 BP 296 EP 306 DI 10.1152/japplphysiol.00667.2016 PG 11 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA EN2GY UT WOS:000395829200008 PM 27909226 ER PT J AU Carson, RA Sahni, O AF Carson, Robert A. Sahni, Onkar TI Scaling Laws for the Peak Overpressure of a Cannon Blast SO JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article ID ATTENUATION AB For large cannons, blast overpressure can have a detrimental effect on the crew in the near field (i.e., within a distance of 50 tube diameters or calibers from the muzzle center) as well as on the support personnel and equipment in the far field (i.e., at a distance greater than 50 calibers). Therefore, an efficient method to determine the peak overpressure due to a cannon blast is highly desired. In this study, we investigate scaling laws for the peak overpressure, due to the primary blast of a large cannon, with the aim that they can be applied as an efficient method to evaluate the peak overpressure in the far field. We explore two types of scaling laws; each type is based on a power-law model involving a prefactor and an exponent as model parameters. The two types of the power-law models differ in the way they incorporate the polar angle dependence. The first type was proposed by Fansler and Schmidt (1983, "The Prediction of Gun Muzzle Blast Properties Utilizing Scaling," U.S. Army Ballistic Research Laboratory, Aberdeen Proving Ground, MD, Report No. ARBRL-TR-02504). They developed a muzzle-center based scaling law (MCSL) in which the polar angle dependence was incorporated through a reference length scale to define a nondimensional or scaled radial distance from the muzzle center and the model parameters were independent of the polar angle. They calibrated the parameters by employing least-squares fit to a wide range of experimental data. In this study, we recalibrated or updated the parameters for the current cannon by using the numerical simulation data for the cannon blast in the near field. Additionally, we developed a second type of scaling law in which the radial distance is defined from the blast center (in contrast to the muzzle center) and scaled using the inner tube diameter. In this model, the angular dependence is incorporated directly into the model parameters. For this model too, we calibrated the parameters by using the numerical simulation data. We observe that both the modified version of the muzzle-center based scaling law as well as the blast-center based scaling law (BCSL) show a significantly closer fit to the numerical and experimental data and achieve a similar level of accuracy. This indicates that the current form or structure of the two types of power-law based scaling models is able to fit well with the near-field data; however, the current methodology requires a calibration process for a given cannon of interest. In the future, with far field data, we plan to evaluate predictions in the far field. C1 [Carson, Robert A.] US Army, ARDEC, Benet Labs, Watervliet, NY 12189 USA. [Sahni, Onkar] Rensselaer Polytech Inst, Mech Aerosp & Nucl Engn Dept, Troy, NY 12180 USA. RP Carson, RA (reprint author), US Army, ARDEC, Benet Labs, Watervliet, NY 12189 USA. FU U.S. Army Armament Research, Development and Engineering Center (ARDEC) Science Fellowship; U.S. Army Research Office [W911NF1410301] FX The authors would like to acknowledge several individuals for their contributions to this work. We would like to thank Andy Anderson, Willy Moss, and Sam Schofield from the Lawrence Livermore National Laboratory for their help related to the numerical simulation based on the ALE3D code. The first author would also like to thank Dr. Don Carlucci at ARDEC and the support of U.S. Army Armament Research, Development and Engineering Center (ARDEC) Science Fellowship. The ARDEC Science Fellowship to the first author was essential for this work. Author Onkar Sahni would like to acknowledge the partial support by the U.S. Army Research Office under Grant W911NF1410301. Additionally, we would like to thank Dr. Robert Dillon and Dr. Eric Kathe for their technical consultation in reviewing this work as well as Dan Crayon, Supervisor of the Armaments Health Monitoring and Mechatronics Branch at Benet Laboratories. NR 23 TC 0 Z9 0 U1 0 U2 0 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0098-2202 EI 1528-901X J9 J FLUID ENG-T ASME JI J. Fluids Eng.-Trans. ASME PD FEB PY 2017 VL 139 IS 2 AR 021204 DI 10.1115/1.4034639 PG 12 WC Engineering, Mechanical SC Engineering GA EM2AW UT WOS:000395119800012 ER PT J AU Patel, AA Hauret, KG Taylor, BJ Jones, BH AF Patel, Avni A. Hauret, Keith G. Taylor, Bonnie J. Jones, Bruce H. TI Non-battle injuries among US Army soldiers deployed to Afghanistan and Iraq, 2001-2013 SO JOURNAL OF SAFETY RESEARCH LA English DT Article; Proceedings Paper CT 6th National Occupational Injury Research Symposium (NOIRS) CY MAY 19-21, 2015 CL Kingwood, WV DE Occupational injury; Military; Surveillance; Medical evacuation; Falls ID WORK-RELATED INJURIES; ENDURING FREEDOM; RISK-FACTORS; PREVENTION; MILITARY; RECOMMENDATIONS; DISEASE AB Introduction: Many non-battle injuries among deployed soldiers are due to occupational-related tasks. Given that non-battle injuries are a significant cause of morbidity and mortality, occupational safety and health are of great concern to the military. Some of the leading causes of non-battle injuries in the military are also common in non-military occupational settings. Nationally, falls and motor-vehicle accidents are leading causes of non-fatal occupational injuries in the civilian workforce. The objective of this research is to identify the leading causes, types, and anatomic locations of non-fatal non-battle injuries in Afghanistan and Iraq. Methods: Non-battle injuries were identified from medical air evacuation records. Causes of air evacuated injuries were identified and coded using the diagnosis and narrative patient history in the air evacuation records. Descriptive statistics were used to report the air evacuated non-battle injury rates, causes, injury types, and anatomic locations. Results: Between 2001 and 2013, there were 68,349 medical air evacuations from Afghanistan and Iraq. Non battle injuries accounted for 31% of air evacuations from Afghanistan and 34% frotri Iraq. These injuries were the leading diagnosis category for air evacuations. The three leading causes of injury for Afghanistan and Iraq, respectively, were sports/physical training (23% and 24%), falls/jumps (19% and 16%), and military vehicle-related accidents (8% and 11%). The leading injury types were fractures (21%), overuse pain and inflammation (16%), and dislocations (11%). Practical applications: Given that over 30% of medical evacuations Of soldiers result from non battle injuries, prevention of such conditions would substantially enhance military readiness during combat. (C) 2016 National Safety Council and Elsevier Ltd. All rights reserved. C1 [Patel, Avni A.] Armed Forces Hlth Surveillance Branch, Def Hlth Agcy, Aurora, CO USA. [Patel, Avni A.; Hauret, Keith G.; Taylor, Bonnie J.; Jones, Bruce H.] US Army, Publ Hlth Ctr, Arlington, VA USA. RP Patel, AA (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM avni.patel.ctr@usuhs.edu NR 24 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4375 EI 1879-1247 J9 J SAFETY RES JI J. Saf. Res. PD FEB PY 2017 VL 60 SI SI BP 29 EP 34 DI 10.1016/j.jsr.2016.11.004 PG 6 WC Ergonomics; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary; Transportation SC Engineering; Public, Environmental & Occupational Health; Social Sciences - Other Topics; Transportation GA EL5BF UT WOS:000394635900007 PM 28160810 ER PT J AU Pollard, KA Tran, PK Letowski, T AF Pollard, Kimberly A. Tran, Phuong K. Letowski, Tomasz TI Morphological differences affect speech transmission over bone conduction SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID ACQUISITION TEST CAT; INDIVIDUAL-DIFFERENCES; BACKGROUND-NOISE; INTELLIGIBILITY; HEARING; SENSITIVITY; RECEPTION; MASKING; DESIGN; GENDER AB In bone conduction (BC), acoustic signals travel through an individual's bones and soft tissues rather than travelling through the air. While bone conduction hearing and communication are important in everyday life, nature, and technology, little is known about how individual differences affect the transmission of bone-conducted sound. Individuals differ in the sizes, shapes, and proportions of their craniofacial bones, leading to potentially different bone-conducted sound transmission effects in different individuals. Individual differences may influence the audibility and quality of bone-conducted sound, and this was studied using speech intelligibility as an assessment criterion for bone-conducted sound transmission. Thirty-two human participants were first subjected to a series of anthropometric craniofacial measurements. Eight morphologically diverse talkers were recorded with bone microphones placed at different skull locations, and 24 morphologically diverse listeners listened to these samples over bone conduction headphones. Modified Rhyme Test results suggest that skull morphology influences BC speech intelligibility and does so differently at different skull locations. Understanding morphological effects can improve bone conduction sound transmission models and may help to enhance BC technology for a diverse user population. C1 [Pollard, Kimberly A.; Tran, Phuong K.; Letowski, Tomasz] US Army Res Lab, 520 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA. RP Pollard, KA (reprint author), US Army Res Lab, 520 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA. EM kpollard@ucla.edu FU Oak Ridge Associated Universities postdoctoral fellowship FX The authors would like to thank all our participants for taking part in this research. We are grateful also to Tim Mermagen for the MRT program, Paula Henry and Ashley Foots for hearing screenings and training, and Jim Faughn for anthropometric training and equipment. This research was conducted under an Oak Ridge Associated Universities postdoctoral fellowship to K.A.P. NR 31 TC 0 Z9 0 U1 0 U2 0 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 EI 1520-8524 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD FEB PY 2017 VL 141 IS 2 BP 936 EP 944 DI 10.1121/1.4976001 PG 9 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA EM4VD UT WOS:000395310100041 PM 28253648 ER PT J AU Kuehn, JT AF Kuehn, John T. TI 'No One Avoided Danger': NAS Kaneohe Bay and the Japanese attack of 7 December 1941 SO MARINERS MIRROR LA English DT Book Review C1 [Kuehn, John T.] US Army, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Kuehn, JT (reprint author), US Army, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0025-3359 EI 2049-680X J9 MARINERS MIRROR JI Mar. Mirror PD FEB PY 2017 VL 103 IS 1 BP 122 EP 123 DI 10.1080/00253359.2017.1273495 PG 2 WC History SC History GA EM1MV UT WOS:000395082600027 ER PT J AU Hauschild, VD DeGroot, DW Hall, SM Grier, TL Deaver, KD Hauret, KG Jones, BH AF Hauschild, Veronique D. DeGroot, David W. Hall, Shane M. Grier, Tyson L. Deaver, Karen D. Hauret, Keith G. Jones, Bruce H. TI Fitness tests and occupational tasks of military interest: a systematic review of correlations SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Review ID PHYSICAL-FITNESS; PERFORMANCE; STANDARDS; PERSONNEL; ABILITY; REQUIREMENTS; FIREFIGHTERS; INJURIES; METAANALYSIS; STRENGTH AB Physically demanding occupations (ie, military, firefighter, law enforcement) often use fitness tests for job selection or retention. Despite numerous individual studies, the relationship of these tests to job performance is not always clear. This review examined the relationship by aggregating previously reported correlations between different fitness tests and common occupational tasks. Search criteria were applied to PUBMED, EBSCO, EMBASE and military sources; scoring yielded 27 original studies providing 533 Pearson correlation coefficients (r) between fitness tests and 12 common physical job task categories. Fitness tests were grouped into predominant health-related fitness components and body regions: cardiorespiratory endurance (CRe); upper body, lower body and trunk muscular strength and muscular endurance (UBs, LBs, TRs, UBe, LBe, TRe) and flexibility (FLX). Meta-analyses provided pooled r's between each fitness component and task category. The CRe tests had the strongest pooled correlations with most tasks (eight pooled r values 0.80-0.52). Next were LBs (six pooled r values >0.50) and UBe (four pooled r values >0.50). UBs and LBe correlated strongly to three tasks. TRs, TRe and FLX did not strongly correlate to tasks. Employers can maximise the relevancy of assessing workforce health by using fitness tests with strong correlations between fitness components and job performance, especially those that are also indicators for injury risk. Potentially useful field-expedient tests include timed-runs (CRe), jump tests (LBs) and push-ups (UBe). Impacts of gender and physiological characteristics (eg, lean body mass) should be considered in future study and when implementing tests. C1 [Hauschild, Veronique D.; DeGroot, David W.; Hall, Shane M.; Grier, Tyson L.; Deaver, Karen D.; Hauret, Keith G.; Jones, Bruce H.] US Army, Publ Hlth Ctr Provis, Injury Prevent Program, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. RP Hauschild, VD (reprint author), US Army, Publ Hlth Ctr Provis, Injury Prevent Program, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM veronique.d.hauschild.civ@mail.mil NR 60 TC 0 Z9 0 U1 0 U2 0 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1351-0711 EI 1470-7926 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD FEB PY 2017 VL 74 IS 2 BP 144 EP 153 DI 10.1136/oemed-2016-103684 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA EL3KB UT WOS:000394516900010 PM 27810940 ER PT J AU Song, SA Sridhara, SK Littlefield, PD AF Song, Sungjin A. Sridhara, Shankar K. Littlefield, Philip D. TI Tympanoplasty Outcomes for Blast-Induced Perforations from Iraq and Afghanistan: 2007-2012 SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article DE blast induced; tympanoplasty; perforations ID TYMPANIC MEMBRANE; INJURY; EXPERIENCE; EAR AB Objective. To describe characteristics of blast-induced tympanic membrane perforations that do not spontaneously heal, evaluate the outcomes of tympanoplasty techniques, and understand the factors associated with surgical success. Setting. Two tertiary military health care institutions. Study Design. Case series with chart review. Subjects and Methods. This study reviewed the practice of 1 military neurotologist and included all tympanoplasties for combat blast-induced perforations from 2007 to 2012, which comprised a total of 55 patients. Surgical outcomes and associated perioperative factors were examined to include size, location, bilateral involvement, timing of surgery, and surgical technique. Results. Fifty-five patients (68 ears) met inclusion criteria. Thirty-six (53%) were total or near-total perforations, and 51% of patients had bilateral perforations. The overall success rate was 77%. It was 82% for lateral grafts and 70% for medial grafts, but the difference between these was not statistically significant. Age was a significant factor, with a success rate of 56% for ages 25 to 34 years, compared with 90% for 20 to 24 and >34 years. Patients who had bilateral sequential tympanoplasties also had lower success rates than those who had only unilateral surgery (62% vs 87%, P = .002). Ossicular disruptions were found in 5 ears, and cholesteatoma was discovered in 8. Surgical timing did not predict success, as the average time until repair was 153 days in successful cases and 151 days in failures. The mean conductive hearing improvement was 13.6 dB, and there were no major complications. Conclusion. Tympanoplasty can be challenging in this population. Age and bilateral surgery were the only independent variables that showed significance. C1 [Song, Sungjin A.; Littlefield, Philip D.] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. [Sridhara, Shankar K.] Dwight D Eisenhower Army Med Ctr, Dept Otolaryngol, Ft Gordon, GA USA. RP Song, SA (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Sungjin.a.song.mil@mail.mil NR 14 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 EI 1097-6817 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD FEB PY 2017 VL 156 IS 2 BP 353 EP 359 DI 10.1177/0194599816677693 PG 7 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA EL8WP UT WOS:000394901400020 PM 27879419 ER PT J AU Lappin, M Gallo, A Krzyzek, M Evans, K Chen,YT AF Lappin, Maura Gallo, Andrew Krzyzek, Monika Evans, Korboi Chen, Yin-Ting TI Sonographic Findings in Subcoracoid Impingement Syndrome: A Case Report and Literature Review SO PM&R LA English DT Review ID CORACOID IMPINGEMENT; SUBSCAPULARIS TENDON; INTERVAL AB Subcoracoid impingement syndrome is a rare and underrecognized cause of anterior shoulder pain. Currently, subcoracoid impingement syndrome is understood to involve impingement of anatomic structures such as the subcoracoid bursa and subscapularis tendon within the coracohumeral space, and there are no reports of sonographic findings in subcoracoid impingement syndrome other than the impingement of thickened subscapularis bursa. Here we report a case of subcoracoid impingement syndrome, including a novel sonographic finding, arthroscopic findings, and a proposed pathophysiology. C1 [Lappin, Maura] Army Community Hosp, Ft Campbell, KY USA. [Gallo, Andrew] Tripler Army Med Ctr, Dept Rehabil Serv, Honolulu, HI 96859 USA. [Krzyzek, Monika; Evans, Korboi] Ft Belvoir Community Hosp, Dept Orthopaed & Rehabil, Ft Belvoir, VA USA. [Chen, Yin-Ting] Walter Reed Natl Mil Med Ctr, Dept Rehabil, Bethesda, MD USA. RP Gallo, A (reprint author), Tripler Army Med Ctr, Dept Rehabil Serv, Honolulu, HI 96859 USA. EM andrew.gallo@gmail.com NR 27 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 EI 1934-1563 J9 PM&R JI PM&R PD FEB PY 2017 VL 9 IS 2 BP 204 EP 209 DI 10.1016/j.pmrj.2016.06.013 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA EM3RF UT WOS:000395231600013 PM 27317912 ER PT J AU Cowley, J Resnik, L Wilken, J Smurr Walters, L Gates, D AF Cowley, Jeffrey Resnik, Linda Wilken, Jason Smurr Walters, Lisa Gates, Deanna TI Movement quality of conventional prostheses and the DEKA Arm during everyday tasks SO PROSTHETICS AND ORTHOTICS INTERNATIONAL LA English DT Article DE Biomechanics in neuromuscular disorders; prosthetic design; testing of prosthetic and orthotic components; upper limb prosthetics ID PERFORMANCE; STROKE; MOTION; USER; COORDINATION; ACCURACY; ENERGY; HAND; VA AB Background: Conventional prosthetic devices fail to restore the function and characteristic movement quality of the upper limb. The DEKA Arm is a new, advanced prosthesis featuring a compound, powered wrist and multiple grip configurations. Objectives: The purpose of this study was to determine if the DEKA Arm improved the movement quality of upper limb prosthesis users compared to conventional prostheses. Study design: Case series. Methods: Three people with transradial amputation completed tasks of daily life with their conventional prosthesis and with the DEKA Arm. A total of 10 healthy controls completed the same tasks. The trajectory of the wrist joint center was analyzed to determine how different prostheses affected movement duration, speed, smoothness, and curvature compared to patients' own intact limbs and controls. Results: Movement quality decreased with the DEKA Arm for two participants, and increased for the third. Prosthesis users made slower, less smooth, more curved movements with the prosthetic limb compared to the intact limb and controls, particularly when grasping and manipulating objects. Conclusion: The effects of one month of training with the DEKA Arm on movement quality varied with participants' skill and experience with conventional prostheses. Future studies should examine changes in movement quality after long-term use of advanced prostheses. Clinical relevance Movement quality with the DEKA Arm may depend on the user's previous experience with conventional prostheses. Quantitative analyses are needed to assess the efficacy of novel prosthetic devices and to better understand how to train people to use them effectively. C1 [Cowley, Jeffrey; Gates, Deanna] Univ Michigan, 401 Washtenaw Ave, Ann Arbor, MI 48109 USA. [Resnik, Linda] Providence VA Med Ctr, Providence, RI USA. [Wilken, Jason; Smurr Walters, Lisa] Brooke Army Med Ctr, San Antonio, TX USA. RP Gates, D (reprint author), Univ Michigan, 401 Washtenaw Ave, Ann Arbor, MI 48109 USA. EM gatesd@umich.edu FU United States (US) Department for Veterans Affairs Rehabilitation Research and Development Service [A9226-R]; Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health [K12HD073945] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by a Merit Research Award #A9226-R from the United States (US) Department for Veterans Affairs Rehabilitation Research and Development Service. D. Gates is supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award Number K12HD073945. NR 35 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0309-3646 EI 1746-1553 J9 PROSTHET ORTHOT INT JI Prosthet. Orthot. Int. PD FEB PY 2017 VL 41 IS 1 BP 33 EP 40 DI 10.1177/0309364616631348 PG 8 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA EL9PD UT WOS:000394951600004 PM 26932980 ER PT J AU Dudley, KA Weng, J Sotres-Alvarez, D Simonelli, G Feliciano, EC Ramirez, M Ramos, AR Loredo, JS Reid, KJ Mossavar-Rahmani, Y Zee, PC Chirinos, DA Gallo, LC Wang, R Patel, SR AF Dudley, Katherine A. Weng, Jia Sotres-Alvarez, Daniela Simonelli, Guido Feliciano, Elizabeth Cespedes Ramirez, Maricelle Ramos, Alberto R. Loredo, Jose S. Reid, Kathryn J. Mossavar-Rahmani, Yasmin Zee, Phyllis C. Chirinos, Diana A. Gallo, Linda C. Wang, Rui Patel, Sanjay R. TI Actigraphic Sleep Patterns of US Hispanics: The Hispanic Community Health Study/Study of Latinos SO SLEEP LA English DT Article DE Hispanic/Latino; sleep; actigraphy ID CARDIOVASCULAR RISK-FACTORS; SELF-REPORTED SLEEP; UNITED-STATES; PSYCHIATRIC-DISORDERS; DIVERSE BACKGROUNDS; MEXICAN-AMERICANS; PUERTO-RICANS; NEUROBEHAVIORAL PERFORMANCE; CUBAN AMERICANS; DURATION AB Study objective: To assess the extent to which objective sleep patterns vary among U.S. Hispanics/Latinos. Methods: We assessed objective sleep patterns in 2087 participants of the Hispanic Community Health Study/Study of Latinos from 6 Hispanic/Latino subgroups aged 18-64 years who underwent 7 days of wrist actigraphy. Results: The age-and sex-standardized mean (SE) sleep duration was 6.82 (0.05), 6.72 (0.07), 6.61 (0.07), 6.59 (0.06), 6.57 (0.10), and 6.44 (0.09) hr among individuals of Mexican, Cuban, Dominican, Central American, Puerto Rican, and South American heritage, respectively. Sleep maintenance efficiency ranged from 89.2 (0.2)% in Mexicans to 86.5 (0.4)% in Puerto Ricans, while the sleep fragmentation index ranged from 19.7 (0.3)% in Mexicans to 24.2 (0.7)% in Puerto Ricans. In multivariable models adjusted for age, sex, season, socioeconomic status, lifestyle habits, and comorbidities, these differences persisted. Conclusions: There are important differences in actigraphically measured sleep across U.S. Hispanic/Latino heritages. Individuals of Mexican heritage have longer and more consolidated sleep, while those of Puerto Rican heritage have shorter and more fragmented sleep. These differences may have clinically important effects on health outcomes. C1 [Dudley, Katherine A.; Patel, Sanjay R.] Beth Israel Deaconess Med Ctr, Div Pulm Crit Care & Sleep Med, Boston, MA 02215 USA. [Dudley, Katherine A.; Weng, Jia; Simonelli, Guido; Ramirez, Maricelle; Wang, Rui; Patel, Sanjay R.] Brigham & Womens Hosp, Div Sleep & Circadian Disorders, 75 Francis St, Boston, MA 02115 USA. [Sotres-Alvarez, Daniela] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Biostat, Collaborat Studies Coordinating Ctr, Chapel Hill, NC USA. [Simonelli, Guido] Ctr Mil Psychiat & Neurosci, Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA. [Feliciano, Elizabeth Cespedes] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. [Feliciano, Elizabeth Cespedes] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. [Feliciano, Elizabeth Cespedes] Kaiser Permanente, Div Res, Oakland, CA USA. [Ramos, Alberto R.] Univ Miami, Dept Neurol, Miami, FL USA. [Loredo, Jose S.] Univ Calif San Diego, Div Pulm & Crit Care Med, San Diego, CA 92103 USA. [Reid, Kathryn J.; Zee, Phyllis C.] Northwestern Univ, Dept Neurol, Chicago, IL 60611 USA. [Mossavar-Rahmani, Yasmin] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA. [Chirinos, Diana A.] Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA. [Gallo, Linda C.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA. [Wang, Rui] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA. RP Dudley, KA (reprint author), 330 Brookline Ave, Boston, MA 02215 USA. EM kdudley@bidmc.harvard.edu FU NHLBI [HL098297, HL007901, HL124767, N01-HC65233]; University of Miami [N01-HC65234]; Albert Einstein College of Medicine [N01-HC65235]; Northwestern University [N01-HC65236]; San Diego State University [N01-HC65237]; National Center on Minority Health and Health Disparities; National Institute of Deafness and Other Communications Disorders; National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; Office of Dietary Supplements FX This study was supported by NHLBI HL098297, HL007901, and HL124767. In addition, the Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from NHLBI to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Center/Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements. NR 61 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0161-8105 EI 1550-9109 J9 SLEEP JI Sleep PD FEB 1 PY 2017 VL 40 IS 2 AR PII zsw049 DI 10.1093/sleep/zsw049 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA EK7UE UT WOS:000394129900012 ER PT J AU Johnson, JL Kim, HC Coburn, JM Chong, ST Chang, NW Robbins, RG Klein, TA AF Johnson, Jaree L. Kim, Heung-Chul Coburn, Jordan M. Chong, Sung-Tae Chang, Nicholas W. Robbins, Richard G. Klein, Terry A. TI Tick surveillance in two southeastern provinces, including three metropolitan areas, of the Republic of Korea during 2014 SO SYSTEMATIC AND APPLIED ACAROLOGY LA English DT Article DE Haemaphysalis longicornis; Haemaphysalis flava; Ixodes nipponensis; tick surveillance; Korea ID SPOTTED-FEVER GROUP; HAEMAPHYSALIS-LONGICORNIS TICKS; THROMBOCYTOPENIA SYNDROME VIRUS; BORNE ENCEPHALITIS-VIRUS; SOUTH-KOREA; MOLECULAR-DETECTION; AMBLYOMMA-TESTUDINARIUM; RICKETTSIA-MONACENSIS; EHRLICHIA-CHAFFEENSIS; GANGWON PROVINCES AB Tick-borne disease surveillance was conducted from March-October 2014 in two southeastern provinces, including three metropolitan areas, in the Republic of Korea (ROK). Three general habitats were surveyed: Grasses (grasses and herbaceous and crawling vegetation), Forests (pine, larch, deciduous, and mixed), and Forests+Grasses. A total of 40,048 ticks (1,480 adults; 24,201 nymphs; 14,367 larvae) belonging to three genera and six species were collected. Haemaphysalis longicornis (84.25%; 33,741) was the most commonly collected tick, followed by Haemaphysalis flava (14.52%; 5,816), Ixodes nipponensis (1.09%; 436), Amblyomma testudinarium (0.07%; 27), Haemaphysalis phasiana (0.06%; 23), and Ixodes turdus (0.01%; 5). Overall, adult ticks accounted for only 3.70% of all ticks collected, while nymphs and larvae accounted for 60.43% and 35.87%, respectively. The proportion of H. longicornis nymphs was highest beginning in March (99.51%), slowly declined through July (82.01%) and then rapidly declined to a low in October (6.45%). Large increases in the proportion of H. longicornis larvae were observed in August (42.05%), September (84.19%) and October (93.55%) following increased numbers of adults collected in June (4.20%), July (17.99%) and August (9.79%). Haemaphysalis flava adults and nymphs were commonly collected from April-May and October, while larvae were first collected from July, with peak numbers collected in August and low numbers collected during September-October. The proportion of I. nipponensis adults was highest in March (75.34%), declined to a low in July (0%), and then increased in September (60.00%) and October (90.32%). Larvae were collected only in August-September and accounted for 64.29% and 20.00% of all I. nipponensis collected during those months. Similar proportions of males and females of H. flava (51.47% and 48.53%, respectively) were collected from all habitats, while significantly more I. nipponensis males (62.20%) were collected than females (37.80%). Conversely, the proportion of H. longicornis females (80.00%) collected was significantly higher than for males (20.00%). Overall, the mean number of ticks collected/hr of collection for all habitats was 156.06/hr of collection. Similar numbers were collected/hr for Forests (172.61) and Grasses (168.64), while lower numbers were collected/hr for Forests+ Grasses (128.12). C1 [Johnson, Jaree L.; Kim, Heung-Chul; Chong, Sung-Tae] Unit 15247, Med Brigade 65, Multifunct Med Battal 168, Med Detachment 5, APO, AP 96205 USA. [Coburn, Jordan M.; Chang, Nicholas W.] US Army, Publ Hlth Command Reg Pacific, Unit 45006, APO, AP 96343 USA. [Robbins, Richard G.] Smithsonian Inst, MSC, Dept Entomol, Walter Reed Biosystemat Unit,MRC 534, 4210 Silver Hill Rd, Suitland, MD 20746 USA. [Klein, Terry A.] MEDDAC Korea, Unit 15281, 65th Med Brigade, APO, AP 96205 USA. [Johnson, Jaree L.] MEDCOM APHC, 5158 Black Hawk Rd, Gunpowder, MD 21010 USA. [Coburn, Jordan M.] Carl R Darnall Army Med Ctr, Dept Prevent Med, 76022 Crockett St, Ft Hood, TX 76544 USA. [Chang, Nicholas W.] US Army, Madigan Army Med Ctr, Dept Prevent Med, 9911B East Johnson St, Jblm, WA 98327 USA. RP Klein, TA (reprint author), MEDDAC Korea, Unit 15281, 65th Med Brigade, APO, AP 96205 USA. EM terry.a.klein2.civ@mail.mil FU Armed Forces Health Surveillance Branch-Global Emerging Infections Surveillance and Response System (AFHSB-GEIS), Silver Spring, MD; 65th Medical Brigade, Yongsan U.S. Army Garrison, Seoul, Korea; Public Health Command District-Korea (Provisional), Camp Humphreys, Republic of Korea FX Funding for this research was provided by the Armed Forces Health Surveillance Branch-Global Emerging Infections Surveillance and Response System (AFHSB-GEIS), Silver Spring, MD, the 65th Medical Brigade, Yongsan U.S. Army Garrison, Seoul, Korea, and the Public Health Command District-Korea (Provisional), Camp Humphreys, Republic of Korea. NR 54 TC 0 Z9 0 U1 0 U2 0 PU SYSTEMATIC & APPLIED ACAROLOGY SOC LONDON, NATURAL HISTORY MUSEUM PI LONDON PA DEPT ENTOMOLOGY, LONDON, SW7 5BD, ENGLAND SN 1362-1971 J9 SYST APPL ACAROL-UK JI Syst. Appl. Acarol. PD FEB PY 2017 VL 22 IS 2 BP 271 EP 288 DI 10.11158/saa.22.2.10 PG 18 WC Entomology SC Entomology GA EM2AM UT WOS:000395118800010 ER PT J AU Haibach, JP Haibach, MA Hall, KS Masheb, RM Little, MA Shepardson, RL Dobmeyer, AC Funderburk, JS Hunter, CL Dundon, M Hausmann, LRM Trynosky, SK Goodrich, DE Kilbourne, AM Knight, SJ Talcott, GW Goldstein, MG AF Haibach, Jeffrey P. Haibach, Michael Ann Hall, Katherine S. Masheb, Robin M. Little, Melissa A. Shepardson, Robyn L. Dobmeyer, Anne C. Funderburk, Jennifer S. Hunter, Christopher L. Dundon, Margaret Hausmann, Leslie R. M. Trynosky, Stephen K. Goodrich, David E. Kilbourne, Amy M. Knight, Sara J. Talcott, Gerald W. Goldstein, Michael G. TI Military and veteran health behavior research and practice: challenges and opportunities SO JOURNAL OF BEHAVIORAL MEDICINE LA English DT Article DE Military; Veteran; Servicemember; Health behavior; Health promotion; Healthcare; Behavioral health ID POSTTRAUMATIC-STRESS-DISORDER; RANDOMIZED CONTROLLED-TRIAL; SUBSTANCE-USE DISORDERS; DEPARTMENT-OF-DEFENSE; ACTIVE-DUTY MILITARY; US AIR-FORCE; WEIGHT MANAGEMENT PROGRAM; ALCOHOL-RELATED OUTCOMES; BODY-MASS INDEX; PRIMARY-CARE AB There are 2.1 million current military servicemembers and 21 million living veterans in the United States. Although they were healthier upon entering military service compared to the general U.S. population, in the longer term veterans tend to be of equivalent or worse health than civilians. One primary explanation for the veterans' health disparity is poorer health behaviors during or after military service, especially areas of physical activity, nutrition, tobacco, and alcohol. In response, the Department of Defense and Department of Veterans Affairs continue to develop, evaluate, and improve health promotion programs and healthcare services for military and veteran health behavior in an integrated approach. Future research and practice is needed to better understand and promote positive health behavior during key transition periods in the military and veteran life course. Also paramount is implementation and evaluation of existing interventions, programs, and policies across the population using an integrated and person centered approach. C1 [Haibach, Jeffrey P.; Kilbourne, Amy M.] US Dept Vet Affairs, Hlth Serv Res & Dev Serv, 810 Vermont Ave NW 10P9H, Washington, DC 20420 USA. [Haibach, Michael Ann] US Air Force, Wright Patterson AFB, OH USA. [Hall, Katherine S.] Durham VA Med Ctr, Durham, NC USA. [Hall, Katherine S.] Duke Univ, Dept Med, Durham, NC USA. [Masheb, Robin M.] VA Connecticut Healthcare Syst, West Haven, CT USA. [Masheb, Robin M.] Yale Sch Med, New Haven, CT USA. [Little, Melissa A.; Talcott, Gerald W.] Univ Tennessee, Ctr Hlth Sci, Ctr Populat Sci, Memphis, TN 38163 USA. [Shepardson, Robyn L.; Funderburk, Jennifer S.] Syracuse VA Med Ctr, VA Ctr Integrated Healthcare, Syracuse, NY USA. [Shepardson, Robyn L.; Funderburk, Jennifer S.] Syracuse Univ, Dept Psychol, Syracuse, NY USA. [Dobmeyer, Anne C.] Deployment Hlth Clin Ctr, Def Ctr Excellence Psychol Hlth, Bethesda, MD USA. [Dobmeyer, Anne C.] Deployment Hlth Clin Ctr, Def Ctr Traumat Brain Injury, Bethesda, MD USA. [Funderburk, Jennifer S.] Univ Rochester, Dept Psychiat, Rochester, NY USA. [Hunter, Christopher L.] Def Hlth Agcy, Patient Ctr Med Home Branch, Clin Support Div, Washington, DC USA. [Dundon, Margaret; Goldstein, Michael G.] US Dept Vet Affairs, Natl Ctr Hlth Promot & Dis Prevent, Durham, NC USA. [Hausmann, Leslie R. M.] VA Pittsburgh Healthcare Syst, Ctr Hlth Equity Res & Promot, Pittsburgh, PA USA. [Hausmann, Leslie R. M.] Univ Pittsburgh, Sch Med, Dept Med, Div Gen Internal Med, Pittsburgh, PA 15213 USA. [Trynosky, Stephen K.] US Dept Vet Affairs, Off Acad Affiliat, Washington, DC USA. [Trynosky, Stephen K.] US Army Reserve, Med Serv Corps, Washington, DC USA. [Goodrich, David E.] VA Ann Arbor Healthcare Syst, Ctr Clin Management Res, Ann Arbor, MI USA. [Kilbourne, Amy M.] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USA. [Knight, Sara J.] Birmingham VA Med Ctr, Birmingham, AL USA. [Knight, Sara J.] Univ Alabama Birmingham, Div Prevent Med, Birmingham, AL USA. RP Haibach, JP (reprint author), US Dept Vet Affairs, Hlth Serv Res & Dev Serv, 810 Vermont Ave NW 10P9H, Washington, DC 20420 USA. EM Jeffrey.Haibach@va.gov; Michael.Glotfelter.1@us.af.mil; Katherine.Hall@duke.edu; Robin.Masheb@yale.edu; Mlittl18@uthsc.edu; Robyn.Shepardson@va.gov; Anne.C.Dobmeyer.mil@mail.mil; Jennifer.Funderburk@va.gov; Christopher.L.Hunter16.mil@mail.mil; Margaret.Dundon@va.gov; Leslie.Hausmann@va.gov; Steve.Trynosky@va.gov; David.Goodrich2@va.gov; Amy.Kilbourne@va.gov; Sara.Knight@va.gov; Wtalcott@uthsc.edu; Michael.Goldstein2@va.gov NR 168 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0160-7715 EI 1573-3521 J9 J BEHAV MED JI J. Behav. Med. PD FEB PY 2017 VL 40 IS 1 BP 175 EP 193 DI 10.1007/s10865-016-9794-y PG 19 WC Psychology, Clinical SC Psychology GA EL0WK UT WOS:000394342300013 PM 27678001 ER PT J AU Haibach, JP Haibach, MA Hall, KS Masheb, RM Little, MA Shepardson, RL Dobmeyer, AC Funderburk, JS Hunter, CL Dundon, M Hausmann, LRM Trynosky, SK Goodrich, DE Kilbourne, AM Knight, SJ Talcott, GW Goldstein, M AF Haibach, Jeffrey P. Haibach, Michael Ann Hall, Katherine S. Masheb, Robin M. Little, Melissa A. Shepardson, Robyn L. Dobmeyer, Anne C. Funderburk, Jennifer S. Hunter, Christopher L. Dundon, Margaret Hausmann, Leslie R. M. Trynosky, Stephen K. Goodrich, David E. Kilbourne, Amy M. Knight, Sara J. Talcott, Gerald W. Goldstein, Michael TI Military and veteran health behavior research and practice: challenges and opportunities (vol 40, pg 175, 2017) SO JOURNAL OF BEHAVIORAL MEDICINE LA English DT Correction C1 [Haibach, Jeffrey P.; Kilbourne, Amy M.] US Dept Vet Affairs, Hlth Serv Res & Dev Serv, 810 Vermont Ave NW 10P9H, Washington, DC 20420 USA. [Haibach, Michael Ann] US Air Force, Wright Patterson AFB, OH USA. [Hall, Katherine S.] Durham VA Med Ctr, Durham, NC USA. [Hall, Katherine S.] Duke Univ, Dept Med, Durham, NC USA. [Masheb, Robin M.] VA Connecticut Healthcare Syst, West Haven, CT USA. [Masheb, Robin M.] Yale Sch Med, New Haven, CT USA. [Little, Melissa A.; Talcott, Gerald W.] Univ Tennessee, Ctr Hlth Sci, Ctr Populat Sci, Memphis, TN 38163 USA. [Shepardson, Robyn L.; Funderburk, Jennifer S.] Syracuse VA Med Ctr, VA Ctr Integrated Healthcare, Syracuse, NY USA. [Shepardson, Robyn L.; Funderburk, Jennifer S.] Syracuse Univ, Dept Psychol, Syracuse, NY USA. [Dobmeyer, Anne C.] Deployment Hlth Clin Ctr, Def Ctr Excellence Psychol Hlth, Bethesda, MD USA. [Dobmeyer, Anne C.] Deployment Hlth Clin Ctr, Def Ctr Traumat Brain Injury, Bethesda, MD USA. [Funderburk, Jennifer S.] Univ Rochester, Dept Psychiat, Rochester, NY USA. [Hunter, Christopher L.] Def Hlth Agcy, Patient Ctr Med Home Branch, Clin Support Div, Washington, DC USA. [Dundon, Margaret; Goldstein, Michael] US Dept Vet Affairs, Natl Ctr Hlth Promot & Dis Prevent, Durham, NC USA. [Hausmann, Leslie R. M.] VA Pittsburgh Healthcare Syst, Ctr Hlth Equity Res & Promot, Pittsburgh, PA USA. [Hausmann, Leslie R. M.] Univ Pittsburgh, Sch Med, Dept Med, Div Gen Internal Med, Pittsburgh, PA 15213 USA. [Trynosky, Stephen K.] US Dept Vet Affairs, Off Acad Affiliat, Washington, DC USA. [Trynosky, Stephen K.] US Army Reserve, Med Serv Corps, Washington, DC USA. [Goodrich, David E.] VA Ann Arbor Healthcare Syst, Ctr Clin Management Res, Ann Arbor, MI USA. [Kilbourne, Amy M.] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USA. [Knight, Sara J.] Birmingham VA Med Ctr, Birmingham, AL USA. [Knight, Sara J.] Univ Alabama Birmingham, Div Prevent Med, Birmingham, AL USA. RP Haibach, JP (reprint author), US Dept Vet Affairs, Hlth Serv Res & Dev Serv, 810 Vermont Ave NW 10P9H, Washington, DC 20420 USA. EM Jeffrey.Haibach@va.gov; Michael.Glotfelter.1@us.af.mil; Katherine.Hall@duke.edu; Robin.Masheb@yale.edu; Mlittl18@uthsc.edu; Robyn.Shepardson@va.gov; Anne.C.Dobmeyer.mil@mail.mil; Jennifer.Funderburk@va.gov; Christopher.L.Hunter16.mil@mail.mil; Margaret.Dundon@va.gov; Leslie.Hausmann@va.gov; Steve.Trynosky@va.gov; David.Goodrich2@va.gov; Amy.Kilbourne@va.gov; Sara.Knight@va.gov; Wtalcott@uthsc.edu; Michael.Goldstein2@va.gov NR 1 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0160-7715 EI 1573-3521 J9 J BEHAV MED JI J. Behav. Med. PD FEB PY 2017 VL 40 IS 1 BP 227 EP 228 DI 10.1007/s10865-016-9801-3 PG 2 WC Psychology, Clinical SC Psychology GA EL0WK UT WOS:000394342300017 PM 27757768 ER PT J AU Cutts, M Wang, YM Yu, QS AF Cutts, Matthew Wang, Yumei Yu, Qisong Kent TI New Perspectives on Building Resilience into Infrastructure Systems SO NATURAL HAZARDS REVIEW LA English DT Article AB Government and industry discussion of the Triple 3 Resilience Target was the focus of the 2014 Cascadia Earthquake Readiness Workshop in Washington, United States. Workshop findings are presented from breakout sessions on critical energy infrastructure, ports and waterways, and emergency management. These prompted the examination of new perspectives on building resilience into lifeline infrastructure systems (lifelines which are critical infrastructure), including a call for new Pacific Northwest regional, collaborative, cross-sector public-private leadership groups to develop coordinated restoration priorities, and enacting policies to promote, enforce, and track the building of resilience in complex, interdependent infrastructure systems. Finally, the resilience prism is introduced, which displays the link between critical infrastructure resilience and the Triple 3 Resilience Target to address postdisaster needs for both individuals and communities. C1 [Cutts, Matthew] US Army Corps Engineers, POB 2946, Portland, OR 97208 USA. [Wang, Yumei] Sustainable Living Solut LLC, 2214 SE Ladd Ave, Portland, OR 97214 USA. [Yu, Qisong Kent] SEFT Consulting Grp LLC, 4800 SW Griffith Dr 135, Beaverton, OR 97005 USA. RP Cutts, M (reprint author), US Army Corps Engineers, POB 2946, Portland, OR 97208 USA. EM matthew.e.cutts@usace.army.mil; yumei.wang@comcast.net; kentyu@seftconsulting.com FU U.S. Army Corps of Engineers Portland District; Society of American Military Engineers; Infrastructure Security Partnership; Cascadia Region Earthquake Workgroup; Centralia College; Northwest Center of Excellence for Clean Energy FX The authors gratefully acknowledge the support of the U.S. Army Corps of Engineers Portland District, the Society of American Military Engineers, the Infrastructure Security Partnership, Cascadia Region Earthquake Workgroup, Centralia College, and the Northwest Center of Excellence for Clean Energy. Each of these organizations played a key role in facilitating the research that led to the Cascadia earthquake readiness workshop and the subsequent publication of this paper. NR 17 TC 0 Z9 0 U1 1 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1527-6988 EI 1527-6996 J9 NAT HAZARDS REV JI Nat. Hazards Rev. PD FEB PY 2017 VL 18 IS 1 SI SI AR UNSP B4015004 DI 10.1061/(ASCE)NH.1527-6996.0000203 PG 7 WC Engineering, Civil; Environmental Studies; Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Geology; Meteorology & Atmospheric Sciences; Water Resources GA EK9KG UT WOS:000394242600008 ER PT J AU Shah, SR Smith, BT Tatara, AM Molina, ER Lee, EJ Piepergerdes, TC Uhrig, BA Guldberg, RE Bennett, GN Wenke, JC Mikos, AG AF Shah, Sarita R. Smith, Brandon T. Tatara, Alexander M. Molina, Eric R. Lee, Esther J. Piepergerdes, Trenton C. Uhrig, Brent A. Guldberg, Robert E. Bennett, George N. Wenke, Joseph C. Mikos, Antonios G. TI Effects of Local Antibiotic Delivery from Porous Space Maintainers on Infection Clearance and Induction of an Osteogenic Membrane in an Infected Bone Defect SO TISSUE ENGINEERING PART A LA English DT Article DE induced membrane; antibiotics; clindamycin; PMMA; infection ID COMPOSITE TISSUE DEFECT; MODEL; CLINDAMYCIN; EXPRESSION; RELEASE; REPAIR; DIFFERENTIATION; RECONSTRUCTION; OSTEOBLASTS; IMPLANTS AB Reconstruction of large bone defects can be complicated by the presence of both infection and local antibiotic administration. This can be addressed through a two-stage reconstructive approach, called the Masquelet technique, that involves the generation of an induced osteogenic membrane over a temporary poly(methyl methacrylate) (PMMA) space maintainer, followed by definitive reconstruction after the induced membrane is formed. Given that infection and antibiotic delivery each have independent effects on local tissue response, the objective of this study is to evaluate the interaction between local clindamycin release and bacterial contamination with regards to infection prevention and the restoration of pro-osteogenic gene expression in the induced membrane. Porous PMMA space maintainers with or without clindamycin were implanted in an 8mm rat femoral defect model with or without Staphylococcus aureus inoculation for 28 days in a full-factorial study design (four groups, n = 8/group). Culture results demonstrated that 8/8 animals in the inoculated/no antibiotic group were infected at 4 weeks, which was significantly reduced to 1/8 animals in the inoculated/antibiotic group. Quantitative polymerase chain reaction analysis demonstrated that clindamycin treatment restores inflammatory cytokine and growth factor expression to the same levels as the no inoculation/no antibiotic group, demonstrating that clindamycin can ameliorate the negative effects of bacterial inoculation and does not itself negatively impact the expression of important cytokines. Main effect analysis shows that bacterial inoculation and clindamycin treatment have independent and interacting effects on the gene expression profile of the induced membrane, further highlighting that antibiotics play an important role in the regeneration of infected defects apart from their antimicrobial properties. C1 [Shah, Sarita R.; Smith, Brandon T.; Tatara, Alexander M.; Molina, Eric R.; Lee, Esther J.; Piepergerdes, Trenton C.; Mikos, Antonios G.] Rice Univ, Dept Bioengn, 6500 Main St,MS-142, Houston, TX 77030 USA. [Uhrig, Brent A.; Guldberg, Robert E.] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA. [Bennett, George N.] Rice Univ, Dept Biosci, Houston, TX USA. [Wenke, Joseph C.] US Army, Extrem Trauma & Regenerat Med, Inst Surg Res, San Antonio, TX USA. RP Mikos, AG (reprint author), Rice Univ, Dept Bioengn, 6500 Main St,MS-142, Houston, TX 77030 USA. EM mikos@rice.edu FU Army; Ruth L. Kirschstein Fellowship from the National Institute of Arthritis and Musculoskeletal and Skin Diseases [F30 AR067606]; Navy; NIH; Air Force; VA; Health Affairs [W81XWH-14-2-0004] FX This work was supported by the Army, Navy, NIH, Air Force, VA, and Health Affairs to support the AFIRM II effort (Award W81XWH-14-2-0004). S.R.S. received support from a Ruth L. Kirschstein Fellowship from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (F30 AR067606). S.R.S., B.T.S., A.M.T., and E.R.M acknowledge the Baylor College of Medicine Medical Scientist Training Program. The authors thank Dr. Elysse Orchard, Ms. Kelly Campbell, and Ms. Tenisha Smith for their assistance with the animal study. NR 39 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 EI 1937-335X J9 TISSUE ENG PT A JI Tissue Eng. Part A PD FEB PY 2017 VL 23 IS 3-4 BP 91 EP 100 DI 10.1089/ten.tea.2016.0389 PG 10 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA EK6HV UT WOS:000394026600001 PM 27998243 ER PT J AU Thompson, T Yu, SH Williams, L Schmidt, RD Garcia-Mendez, R Wolfenstine, J Allen, JL Kioupakis, E Siegel, DJ Sakamoto, J AF Thompson, Travis Yu, Seungho Williams, Logan Schmidt, Robert D. Garcia-Mendez, Regina Wolfenstine, Jeff Allen, Jan L. Kioupakis, Emmanouil Siegel, Donald J. Sakamoto, Jeff TI Electrochemical Window of the Li-Ion Solid Electrolyte Li7La3Zr2O12 SO ACS ENERGY LETTERS LA English DT Article ID OPTICAL-ABSORPTION; PHASE-STABILITY; BATTERIES; CONDUCTIVITY; 1ST-PRINCIPLES; INTERPHASES; TEMPERATURE; CHALLENGES; CONDUCTORS; Y3AL5O12 AB The recent discovery of fast ion-conducting solid electrolytes could enable solid-state and other advanced battery chemistries with higher energy densities and enhanced safety. In addition to high ionic conductivity, a viable electrolyte should also exhibit an electrochemical window that is wide enough to suppress undesirable electronic transport (i.e., self-discharge and/or short circuiting) arising from charge injection or extraction from the electrodes. Here, direct current chronoamperometry, alternating current electrochemical impedance spectroscopy, and optical absorption band gap measurements are combined with first-principles calculations to systematically characterize the electrochemical window of the promising superionic conductor Li7La3Zr2O12 (LLZO). Negligible electronic current was measured within LLZO for a wide range of voltages relevant for high-voltage cathodes. This auspicious behavior is consistent with both the large band gap (similar to 6 eV) predicted for LLZO and the absolute positions of its band edges. These features imply that a wide electrochemical window is an intrinsic property of LLZO, facilitating its use in next-generation batteries. C1 [Thompson, Travis; Yu, Seungho; Schmidt, Robert D.; Siegel, Donald J.; Sakamoto, Jeff] Univ Michigan, Dept Mech Engn, 2350 Hayward Ave, Ann Arbor, MI 48109 USA. [Williams, Logan; Garcia-Mendez, Regina; Kioupakis, Emmanouil; Siegel, Donald J.; Sakamoto, Jeff] Univ Michigan, Dept Mat Sci & Engn, 2350 Hayward Ave, Ann Arbor, MI 48109 USA. [Wolfenstine, Jeff; Allen, Jan L.] RDRL SED C, Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Siegel, DJ; Sakamoto, J (reprint author), Univ Michigan, Dept Mech Engn, 2350 Hayward Ave, Ann Arbor, MI 48109 USA.; Siegel, DJ; Sakamoto, J (reprint author), Univ Michigan, Dept Mat Sci & Engn, 2350 Hayward Ave, Ann Arbor, MI 48109 USA. EM djsiege@umich.edu; jeffsaka@umich.edu OI Siegel, Donald/0000-0001-7913-2513 FU U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Vehicle Technologies Office (VTO); Advanced Battery Material Research (BMR) program [DE-EE-0006821]; National Science Foundation [DMR-1561008]; Office of Science of the U.S. Department of Energy [DE-AC02-05CH11231]; U.S. Army Research Laboratory (ARL); Kwanjeong Educational Foundation FX This work was supported by the U.S. Department of Energy (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Vehicle Technologies Office (VTO) and Advanced Battery Material Research (BMR) program under Grant No. DE-EE-0006821. L.W and E.K. were supported by the National Science Foundation under Grant No. DMR-1561008. Computational resources were provided by the National Energy Research Scientific Computing Center, which is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. J.W. and J.L.A. acknowledge support of the U.S. Army Research Laboratory (ARL). S.Y. acknowledges support from the Kwanjeong Educational Foundation. J.S. acknowledges discussions with Prof. Venkataraman Thangadurai who helped to inspire this study. NR 41 TC 0 Z9 0 U1 5 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2380-8195 J9 ACS ENERGY LETT JI ACS Energy Lett. PD FEB PY 2017 VL 2 IS 2 BP 462 EP 468 DI 10.1021/acsenergylett.6b00593 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Science & Technology - Other Topics; Materials Science GA EK7BH UT WOS:000394080000026 ER PT J AU Dong, H Napadensky, E Orlicki, JA Snyder, JF Chantawansri, TL Kapllani, A AF Dong, Hong Napadensky, Eugene Orlicki, Joshua A. Snyder, James F. Chantawansri, Tanya L. Kapllani, Alda TI Cellulose Nanofibrils and Diblock Copolymer Complex: Micelle Formation and Enhanced Dispersibility SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING LA English DT Article DE cellulose nanofibrils; diblock copolymer; surface modification; hydrogen bonding interactions; micelles; dispersion ID BLOCK-COPOLYMERS; SURFACE MICELLES; NANOCRYSTALS; NANOCELLULOSES; ADSORPTION AB A great challenge to the utilization of bioderived cellulose nanofibrils (CNFs) is related to dispersion, where the hydrophilic nature makes them difficult to disperse in both organic solvents and hydrophobic polymers. In this study, an amphiphilic diblock copolymer, poly(methyl methacrylate-b-acrylic acid) (PMMA-b-PAA), which contains a short interactive block of PAA and a long hydrophobic block of PMMA, was utilized to modify the surface of CNFs covered with carboxylic acid groups (CNF-COOH). The PAA block binds to the surface carboxylic acid groups on the CNFs through the formation of multiple hydrogen bonds, while the hydrophobic PMMA block enables better dispersion of the CNFs as well as interfacial adhesion with the matrix polymer. The attachment of PMMA-b-PAA to the CNFs was confirmed through Fourier transform infrared spectroscopy. Micelles were observed to form from a dispersion of CNF-COOH/PMMA-b-PAA complex in H2O. Good dispersion with individualized nanofibrils has been achieved in dimethylformamide, dimethyl sulfoxide, ethanol, and methanol even when a low amount of block copolymer was functionalized on the CNF surface. The dispersion level of CNF-COOH/PMMA-b-PAA correlates well with the dielectric constant of the solvents, where solvents with high dielectric constants are better able to disperse the PMMA-b-PAA modified nanofibrils. C1 [Dong, Hong; Napadensky, Eugene; Orlicki, Joshua A.; Snyder, James F.; Chantawansri, Tanya L.; Kapllani, Alda] US Army, Res Lab, Macromol Sci & Technol Branch, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. [Dong, Hong] US Army, Res Lab, Biotechnol Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Dong, Hong] Gen Tech Serv, 3100 NJ-138, Wall, NJ 07719 USA. RP Dong, H (reprint author), US Army, Res Lab, Macromol Sci & Technol Branch, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.; Dong, H (reprint author), US Army, Res Lab, Biotechnol Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.; Dong, H (reprint author), Gen Tech Serv, 3100 NJ-138, Wall, NJ 07719 USA. EM hong.dong.ctr@mail.mil FU U.S. Army Research Laboratory [W911QX-14-C-0016] FX The research reported in this document was performed in connection with contract/instrument W911QX-14-C-0016 with the U.S. Army Research Laboratory. The authors thank Dr. Alan Rudie and Mr. Richard Reiner at USDA Forest Product Laboratory (FPL) for providing the CNF dispersions. Dr. Dimitra N. Stratis-Cullum and Dr. Eric Gobrogge at Army Research Laboratory (ARL) are acknowledged for discussions and help in FT-IR study. NR 32 TC 0 Z9 0 U1 6 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2168-0485 J9 ACS SUSTAIN CHEM ENG JI ACS Sustain. Chem. Eng. PD FEB PY 2017 VL 5 IS 2 BP 1264 EP 1271 DI 10.1021/acssuschemeng.6b00811 PG 8 WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Chemical SC Chemistry; Science & Technology - Other Topics; Engineering GA EK0RK UT WOS:000393634600004 ER PT J AU Recchia, SS Tenorio, M Horner, S Zheng, JQ Pelegri, AA AF Recchia, Stephen S. Tenorio, Max Horner, Suzanne Zheng, James Q. Pelegri, Assimina A. TI Analytical model of nonlinear twist dependency for Kevlar yarn based on local filament strain SO ACTA MECHANICA LA English DT Article ID ELASTIC PROPERTIES; FIBER; COMPOSITES; STRENGTH; MODULUS; DAMAGE AB Kevlar KM2 600 denier yarn is often twisted to improve yarn load at failure. It is noted in ASTM-D-7269 that twisting KM2 past five twists per inch can cause a lower load at failure. Understanding the physics that govern the load decrease at higher twist ratios can lead to improved yarn designs, possibly stronger than the peak values currently seen at three turns per inch. Increasing yarn strength would enable enhanced usage of Kevlar yarn, improving chord and fabric structures. This paper describes the testing and finite element analysis methods used to probe yarn tenacity as a function of twist per inch. The performed tests indicate that strength decreases as the yarn is twisted past three twists per inch and are in agreement with previously conducted trials. The finite element model results were compared to test data performed in this study and ones reported in literature. Employing the validated simulation data, yarn damage and failure pictorials were produced. The frames showing the yarn at varying displacements illustrate the yarn failure propagation at varying twist-per-turn values. It is suggested that yarn softening as a function of twist per turn is attributed to higher strains of the outer filaments, at large amounts of twist, than of the core filaments. Previous work has shown a dependency of local filament strength to its yarn radius. The focus of this paper is to derive a comprehensive filament model, using finite element analysis, that incorporates the yarn strain gradient and is experimentally verified. C1 [Recchia, Stephen S.] Rutgers State Univ, Adv Mat & Structures Lab, Sch Engn, Piscataway, NJ 08854 USA. [Tenorio, Max; Pelegri, Assimina A.] Rutgers State Univ, Mech & Aerosp Engn Sch Engn, Piscataway, NJ 08854 USA. [Horner, Suzanne; Zheng, James Q.] US Army, Soldier Protect & Individual Equipment, Tech Management Directorate, 10170 Beach Rd, Ft Belvoir, VA 22060 USA. RP Pelegri, AA (reprint author), Rutgers State Univ, Mech & Aerosp Engn Sch Engn, Piscataway, NJ 08854 USA. EM pelegri@jove.rutgers.edu NR 33 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0001-5970 EI 1619-6937 J9 ACTA MECH JI Acta Mech. PD FEB PY 2017 VL 228 IS 2 BP 561 EP 574 DI 10.1007/s00707-016-1721-3 PG 14 WC Mechanics SC Mechanics GA EK8MJ UT WOS:000394177700012 ER PT J AU Al-Khateeb, AA Limberg, JK Barnes, JN Joyner, MJ Charkoudian, N Curry, TB AF Al-Khateeb, Abdulrahman A. Limberg, Jacqueline K. Barnes, Jill N. Joyner, Michael J. Charkoudian, Nisha Curry, Timothy B. TI Acute cyclooxygenase inhibition and baroreflex sensitivity in lean and obese adults SO CLINICAL AUTONOMIC RESEARCH LA English DT Article DE Ibuprofen; Inflammation; Autonomic nervous system; Cardiovagal; Sympathetic ID SYMPATHETIC-NERVE ACTIVITY; CORONARY-ARTERY-DISEASE; SYMPATHOVAGAL IMBALANCE; BLOOD-PRESSURE; SEX-DIFFERENCES; HUMANS; INFLAMMATION; INCREASES; RESPONSES; HYPERTENSION AB Obese adults exhibit increased levels of inflammation, which may negatively affect blood pressure regulation. Based on existing literature, we hypothesized: (1) baroreflex sensitivity would be lower in obese adults when compared to lean adults; (2) acute ibuprofen (IBU, a cyclooxygenase inhibitor and nonsteroidal antiinflammatory agent) administration would increase baroreflex sensitivity in obese adults, with no effect in lean adults. Seven lean (4 male, 3 female) and six obese (5 M, 1 F) adults completed two visits randomized to control (CON) or IBU (800 mg oral). On each visit, blood pressure (intra-arterial catheter), heart rate (ECG), and muscle sympathetic nerve activity (MSNA, microneurography) were measured continuously. Sympathetic and cardiac baroreflex sensitivities were assessed using the modified Oxford technique. Measures of systemic inflammation [C-reactive protein (CRP) and interleukin-6 (IL-6)] were higher in obese adults when compared to lean adults and tended to decrease with IBU (IL-6: p < 0.05; CRP: p = 0.14). Cardiac baroreflex sensitivity was lower in obese adults (14 +/- 2 vs. 24 +/- 2 ms/mmHg, p = 0.02), whereas sympathetic baroreflex sensitivity was higher in obese adults (-3.6 +/- 0.5 vs. -2.1 +/- 0.5 bursts/100 beats/mmHg, p = 0.03) when compared to lean. There was no effect of IBU on cardiac or sympathetic baroreflex sensitivity in either group (p value range 0.20-0.71). Despite obese individuals exhibiting higher levels of systemic inflammation and lower cardiac baroreflex sensitivity when compared to lean adults, an acute dose of IBU has no effect on cardiac or sympathetic baroreflex sensitivity. C1 [Al-Khateeb, Abdulrahman A.; Limberg, Jacqueline K.; Barnes, Jill N.; Joyner, Michael J.; Curry, Timothy B.] Mayo Clin, Dept Anesthesiol, 200 1st St SW, Rochester, MN 55905 USA. [Al-Khateeb, Abdulrahman A.] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia. [Charkoudian, Nisha] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. RP Curry, TB (reprint author), Mayo Clin, Dept Anesthesiol, 200 1st St SW, Rochester, MN 55905 USA. EM Curry.Timothy@mayo.edu FU NIH from the National Center for Advancing Translational Sciences (NCATS) [HL083947, DK082424, AG038067, UL1 TR000135]; American Heart Association [AHA 0750036Z] FX NIH HL083947 (NC, MJJ), DK082424 (TBC), AG038067 (JNB), and UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS). AHA 0750036Z (NC) from the American Heart Association. NR 28 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0959-9851 EI 1619-1560 J9 CLIN AUTON RES JI Clin. Auton. Res. PD FEB PY 2017 VL 27 IS 1 BP 17 EP 23 DI 10.1007/s10286-016-0389-z PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA EK8OK UT WOS:000394183100004 PM 27838779 ER PT J AU Escher, BI Hackermuller, J Polte, T Scholz, S Aigner, A Altenburger, R Bohme, A Bopp, SK Brack, W Busch, W Chadeau-Hyam, M Covaci, A Eisentrager, A Galligan, JJ Garcia-Reyero, N Hartung, T Hein, M Herberth, G Jahnke, A Kleinjans, J Kluver, N Krauss, M Lamoree, M Lehmann, I Luckenbach, T Miller, GW Muller, A Phillips, DH Reemtsma, T Rolle-Kampczyk, U Schuurmann, G Schwikowski, B Tan, YM Trump, S Walter-Rohde, S Wambaugh, JF AF Escher, Beate I. Hackermuller, Joerg Polte, Tobias Scholz, Stefan Aigner, Achim Altenburger, Rolf Boehme, Alexander Bopp, Stephanie K. Brack, Werner Busch, Wibke Chadeau-Hyam, Marc Covaci, Adrian Eisentraeger, Adolf Galligan, James J. Garcia-Reyero, Natalia Hartung, Thomas Hein, Michaela Herberth, Gunda Jahnke, Annika Kleinjans, Jos Kluever, Nils Krauss, Martin Lamoree, Marja Lehmann, Irina Luckenbach, Till Miller, Gary W. Mueller, Andrea Phillips, David H. Reemtsma, Thorsten Rolle-Kampczyk, Ulrike Schueuermann, Gerrit Schwikowski, Benno Tan, Yu-Mei Trump, Saskia Walter-Rohde, Susanne Wambaugh, John F. TI From the exposome to mechanistic understanding of chemical-induced adverse effects SO ENVIRONMENT INTERNATIONAL LA English DT Review DE Exposome; AOP; Systems toxicology; Systems biology; Systems chemistry; Risk assessment ID EFFECT-DIRECTED ANALYSIS; INTEGRATED TESTING STRATEGIES; ENVIRONMENTAL RISK-ASSESSMENT; HUMAN HAZARD CHARACTERIZATION; GENE-EXPRESSION DATA; OUTCOME PATHWAYS; PERFLUORINATED COMPOUNDS; ORGANIC MICROPOLLUTANTS; SYSTEMS TOXICOLOGY; SAFETY ASSESSMENT AB The exposome encompasses an individual's exposure to exogenous chemicals, as well as endogenous chemicals that are produced or altered in response to external stressors. While the exposome concept has been established for human health, its principles can be extended to include broader ecological issues. The assessment of exposure is tightly interlinked with hazard assessment. Here, we explore if mechanistit understanding of the causal links between exposure and adverse effects on human health and the environment can be improved by integrating the exposome approach with the adverse outcome pathway (AOP) concept that structures and organizes the sequence of biological events from an initial molecular interaction of a chemical with a biological target to an adverse outcome. Complementing exposome research with the AOP concept may facilitate a mechanistic understanding of stress-induced adverse effects, examine the relative contributions from various components of the exposome, determine the primary risk drivers in complex mixtures, and promote an integrative assessment of chemical risks for both human and environmental health. (C) 2016 The Authors. Published by Elsevier Ltd. C1 [Escher, Beate I.; Hackermuller, Joerg; Polte, Tobias; Scholz, Stefan; Altenburger, Rolf; Boehme, Alexander; Brack, Werner; Busch, Wibke; Hein, Michaela; Herberth, Gunda; Jahnke, Annika; Kluever, Nils; Krauss, Martin; Lehmann, Irina; Luckenbach, Till; Mueller, Andrea; Reemtsma, Thorsten; Rolle-Kampczyk, Ulrike; Schueuermann, Gerrit; Trump, Saskia] UFZ Helmholtz Ctr Environm Res, Permoserstr 15, D-04318 Leipzig, Germany. [Aigner, Achim] Univ Leipzig, Rudolf Boehm Inst Pharmacol & Toxicol, Clin Pharmacol, Haertelstr 16-18, D-04107 Leipzig, Germany. [Bopp, Stephanie K.] European Commiss Joint Res Ctr, Directorate Hlth Consumers & Reference Mat F, Via E Fermi 2749, I-21027 Ispra, VA, Italy. [Chadeau-Hyam, Marc] Univ London, Imperial Coll, Dept Epidemiol & Biostat, Sch Publ Hlth, St Marys Campus,Norfolk Pl, London W2 1PG, England. [Covaci, Adrian] Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium. [Eisentraeger, Adolf; Walter-Rohde, Susanne] German Environm Agcy UBA, Dessau Rosslau, Germany. [Galligan, James J.] Vanderbilt Univ, Sch Med, AB Hancock Jr Mem Lab Canc Res, Dept Biochem, Nashville, TN 37232 USA. [Garcia-Reyero, Natalia] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Starkville, MS USA. [Hartung, Thomas] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Hartung, Thomas] Univ Konstanz, Constance, Germany. [Kleinjans, Jos] Maastricht Univ, Dept Toxicogen, NL-6200 MD Maastricht, Netherlands. [Lamoree, Marja] Vrije Univ Amsterdam, Fac Earth & Life Sci, Inst Environm Studies, NL-1081 HV Amsterdam, Netherlands. [Miller, Gary W.] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, GA 30322 USA. [Phillips, David H.] Kings Coll London, MRC PHE Ctr Environm & Hlth, Analyt & Environm Sci Div, London SE1 9NH, England. [Schueuermann, Gerrit] Tech Univ Bergakad Freiberg, Inst Organ Chem, D-09596 Freiberg, Germany. [Schwikowski, Benno] Inst Pasteur, Syst Biol Lab, Paris, France. [Tan, Yu-Mei] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA. [Wambaugh, John F.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA. RP Escher, BI (reprint author), UFZ Helmholtz Ctr Environm Res, Dept Cell Toxicol, Permoserstr 15, D-04318 Leipzig, Germany. EM beate.escher@ufz.de RI Hackermuller, Jorg/F-2494-2016; Schuurmann, Gerrit/E-7962-2017 OI Hackermuller, Jorg/0000-0003-4920-7072; Schuurmann, Gerrit/0000-0002-3789-1703 FU Integrated Project "Exposome" at UFZ FX This review was informed by a Workshop organized by the Integrated Project EXPOSOME at the UFZ Helmholtz Centre for Environmental Research in Leipzig, Germany, in December 2015. The workshop participants comprised all coauthors plus Stephen M. Rappaport (University of California, Berkeley), Kai-Uwe Goss (UFZ) and Urs Berger (UFZ). We thank the Integrated Project "Exposome" at UFZ for funding of the workshop. We thank Stephen M. Rappaport for helpful discussions and review of the manuscript. The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the European Commission, the German Environment Agency or the U.S. EPA. The authors declare they have no actual or potential competing financial interests. NR 99 TC 0 Z9 0 U1 2 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-4120 EI 1873-6750 J9 ENVIRON INT JI Environ. Int. PD FEB PY 2017 VL 99 BP 97 EP 106 DI 10.1016/j.envint.2016.11.029 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA EK6UZ UT WOS:000394062700008 PM 27939949 ER PT J AU Pokrzywinski, KL Tilney, CL Modla, S Caplan, JL Ross, J Warner, ME Coyne, KJ AF Pokrzywinski, Kaytee L. Tilney, Charles L. Modla, Shannon Caplan, Jeffery L. Ross, Jean Warner, Mark E. Coyne, Kathryn J. TI Effects of the bacterial algicide IRI-160AA on cellular morphology of harmful dinoflagellates SO HARMFUL ALGAE LA English DT Article DE Dinoflagellate; Chromosome decompaction; Nucleus; Cell cycle inhibition; Algicide; Morphology ID TOXIC DINOFLAGELLATE; PFIESTERIA-PISCICIDA; CHROMOSOMES; BLOOMS; GROWTH; DNA; DINOPHYCEAE; DEATH; BIREFRINGENCE; HETEROSIGMA AB The algicide, IRI-160AA, induces mortality in dinoflagellates but not other species of algae, suggesting that a shared characteristic or feature renders this class of phytoplankton vulnerable to the algicide. In contrast to other eukaryotic species, the genome of dinoflagellates is stabilized by high concentrations of divalent cations and transition metals and contains large amounts of DNA with unusual base modifications. These distinctions set dinoflagellates apart from other phytoplankton and suggest that the nucleus may be a dinoflagellate-specific target for IRI-160AA. In this study, morphological and ultrastructural changes in three dinoflagellate species, Prorocentrum minimum, Karlodinium veneficum and Gyrodinium instriatum, were evaluated after short-term exposure to IRI-160AA using super resolution structured illumination microscopy (SR-SIM) and transmission electron microscopy (TEM). Exposure to the algicide resulted in cytoplasmic membrane blebbing, differing chloroplast morphologies, nuclear expansion, and chromosome expulsion and/or destabilization. TEM analysis showed that chromosomes of algicide-treated K. veneficum appeared electron dense with fibrous protrusions. In algicide-treated P. minimum and G. instriatum, chromosome decompaction occurred, while for P. minimum, nuclear expulsion was also observed for several cells. Results of this investigation demonstrate that exposure to the algicide destabilizes dinoflagellate chromosomes, although it was not clear if the nucleus was the primary target of the algicide or if the observed effects on chromosomal structure were due to downstream impacts. In all cases, changes in cellular morphology and ultrastructure were observed within two hours, suggesting that the algicide may be an effective and rapid approach to mitigate dinoflagellate blooms. (C) 2017 Elsevier B.V. All rights reserved. C1 [Pokrzywinski, Kaytee L.; Tilney, Charles L.; Warner, Mark E.; Coyne, Kathryn J.] Univ Delaware, Coll Earth Ocean & Environm, 700 Pilottown Rd, Lewes, DE 19958 USA. [Modla, Shannon; Caplan, Jeffery L.; Ross, Jean] Univ Delaware, Delaware Biotechnol Inst, Biomaging Ctr, 15 Innovat Way, Newark, DE 19711 USA. [Pokrzywinski, Kaytee L.] US Army Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Tilney, Charles L.] FWC Fish & Wildlife Res Inst, St Petersburg, FL 33701 USA. RP Coyne, KJ (reprint author), 700 Pilottown Rd, Lewes, DE 19958 USA. EM kcoyne@udel.edu FU National Oceanic and Atmospheric Association (NOAA) Prevention, Mitigation and Control of HABs (PCM HAB) program [NA10NOS4780136, PCM034]; National Science Foundation EPSCoR Grant [IIA-1301765]; State of Delaware FX This work was supported by the National Oceanic and Atmospheric Association (NOAA) Prevention, Mitigation and Control of HABs (PCM HAB) program (Grant # NA10NOS4780136 to KJC and MEW, contribution number PCM034). This work was also made possible by the National Science Foundation EPSCoR Grant No.IIA-1301765 and the State of Delaware.[SS] NR 44 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1568-9883 EI 1878-1470 J9 HARMFUL ALGAE JI Harmful Algae PD FEB PY 2017 VL 62 BP 127 EP 135 DI 10.1016/j.hal.2016.12.004 PG 9 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA EK4WY UT WOS:000393929800013 PM 28118887 ER PT J AU Lu, Z Wang, C AF Lu, Zhuo Wang, Cliff TI Enabling Network Anti-Inference via Proactive Strategies: A Fundamental Perspective SO IEEE-ACM TRANSACTIONS ON NETWORKING LA English DT Article DE Proactive strategies; network inference and tomography; network dynamics; security ID TOMOGRAPHY; INFORMATION AB Network inference is an effective mechanism to infer end-to-end flow rates and has enabled a variety of applications (e.g., network surveillance and diagnosis). This paper is focused on the opposite side of network inference, i.e., how to make inference inaccurate, which we call network anti-inference. As most research efforts have been focused on developing efficient inference methods, a design of anti-inference is largely overlooked. Anti-inference scenarios can rise when network inference is not desirable, such as in clandestine communication and military applications. Our objective is to explore network dynamics to provide anti-inference. In particular, we consider two proactive strategies that cause network dynamics: transmitting deception traffic and changing routing to mislead the inference. We build an analytical framework to quantify the induced inference errors of the proactive strategies that maintain limited costs. We find by analysis and simulations that for deception traffic, a simple random transmission strategy can achieve inference errors on the same order of the best coordinated transmission strategy, while changing routing can cause the inference errors of higher order than any deception traffic strategy. Our results not only reveal the fundamental perspective on proactive strategies, but also offer the guidance into the practical design of anti-inference. C1 [Lu, Zhuo] Univ Memphis, Dept Comp Sci, Memphis, TN 38152 USA. [Wang, Cliff] US Army, Res Off, Res Triangle Pk, NC 27709 USA. RP Lu, Z (reprint author), Univ Memphis, Dept Comp Sci, Memphis, TN 38152 USA. EM zhuo.lu@memphis.edu; cliff.wang@us.army.mil FU Division of Computer and Network Systems through the National Science Foundation [1464114] FX The work of Z. Lu was supported by the Division of Computer and Network Systems through the National Science Foundation under Grant 1464114. Preliminary results were presented at the IEEE Conference on Computer Communications (INFOCOM) 2015. NR 26 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1063-6692 EI 1558-2566 J9 IEEE ACM T NETWORK JI IEEE-ACM Trans. Netw. PD FEB PY 2017 VL 25 IS 1 BP 43 EP 55 DI 10.1109/TNET.2016.2553666 PG 13 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA EN2UY UT WOS:000395867000004 ER PT J AU Ma, L He, T Swami, A Towsley, D Leung, KK AF Ma, Liang He, Ting Swami, Ananthram Towsley, Don Leung, Kin K. TI Network Capability in Localizing Node Failures via End-to-End Path Measurements SO IEEE-ACM TRANSACTIONS ON NETWORKING LA English DT Article DE Network tomography; failure localization; identifiability condition; maximum identifiability index AB We investigate the capability of localizing node failures in communication networks from binary states (normal/failed) of end-to-end paths. Given a set of nodes of interest, uniquely localizing failures within this set requires that different observable path states associate with different node failure events. However, this condition is difficult to test on large networks due to the need to enumerate all possible node failures. Our first contribution is a set of sufficient/necessary conditions for identifying a bounded number of failures within an arbitrary node set that can be tested in polynomial time. In addition to network topology and locations of monitors, our conditions also incorporate constraints imposed by the probing mechanism used. We consider three probing mechanisms that differ according to whether measurement paths are: (i) arbitrarily controllable; (ii) controllable but cycle-free; or (iii) uncontrollable (determined by the default routing protocol). Our second contribution is to quantify the capability of failure localization through: 1) the maximum number of failures (anywhere in the network) such that failures within a given node set can be uniquely localized and 2) the largest node set within which failures can be uniquely localized under a given bound on the total number of failures. Both measures in 1) and 2) can be converted into the functions of a per-node property, which can be computed efficiently based on the above sufficient/necessary conditions. We demonstrate how measures 1) and 2) proposed for quantifying failure localization capability can be used to evaluate the impact of various parameters, including topology, number of monitors, and probing mechanisms. C1 [Ma, Liang; He, Ting] IBM Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. [Towsley, Don] Univ Massachusetts, Amherst, MA 01003 USA. [Leung, Kin K.] Imperial Coll, London SW7 2AZ, England. RP Ma, L (reprint author), IBM Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA. EM maliang@us.ibm.com; the@us.ibm.com; ananthram.swami.civ@mail.mil; towsley@cs.umass.edu; kin.leung@imperial.ac.uk FU U.S. Army Research Laboratory; U.K. Ministry of Defence [W911NF-06-3-0001] FX This work was supported in part by the U.S. Army Research Laboratory and the U.K. Ministry of Defence under Grant W911NF-06-3-0001. NR 29 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1063-6692 EI 1558-2566 J9 IEEE ACM T NETWORK JI IEEE-ACM Trans. Netw. PD FEB PY 2017 VL 25 IS 1 BP 434 EP 450 DI 10.1109/TNET.2016.2584544 PG 17 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA EN2UY UT WOS:000395867000033 ER PT J AU Wu, DR Lance, BJ Lawhern, VJ AF Wu, Dongrui Lance, Brent J. Lawhern, Vernon J. TI Guest Editorial for the Special Section on Brain Computer Interface (BCI) SO IEEE TRANSACTIONS ON FUZZY SYSTEMS LA English DT Editorial Material C1 [Wu, Dongrui] DataNova, Clifton Pk, NY 12065 USA. [Lance, Brent J.; Lawhern, Vernon J.] Human Res & Engn Directorate, Army Res Lab, Adelphi, MD 20783 USA. RP Wu, DR (reprint author), DataNova, Clifton Pk, NY 12065 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1063-6706 EI 1941-0034 J9 IEEE T FUZZY SYST JI IEEE Trans. Fuzzy Syst. PD FEB PY 2017 VL 25 IS 1 BP 1 EP 2 DI 10.1109/TFUZZ.2017.2652799 PG 2 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA EO0MW UT WOS:000396393100001 ER PT J AU Riveros, GA Ayala-Burgos, JL Dixon, D AF Riveros, Guillermo A. Ayala-Burgos, Jorge L. Dixon, DeAnna TI Numerical Investigation of Diagonals in Miter Gates: Looking for the Optimum Prestressing SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES LA English DT Article AB This article presents a proposed methodology to acquire optimum prestressing on diagonals in miter gates. The study uses three-dimensional (3D) numerical simulation of miter gates that includes all the geometrical details of the most commonly used miter gates. The simulation is used to attain vertical and lateral displacements at the miter end when the gate is mitered and in the operation for different prestressing forces. The simulation results allow the development of design curves that are used to obtain the optimum prestressing loading. These design curves can also be used to verify that the displacements of a gate are within tolerances for existing levels of prestressing. The analyses are compared with the existing criteria. The comparison shows that the miter gate leaf is not limited to only one prestressing combination, as prescribed by the design criteria, but several prestressing combinations evaluated from the numerical experiments can also provide the adequate torsional capacity. Furthermore, the study shows that the design criteria estimates a higher prestressing that likely causes a reduction in fatigue life in the diagonal connections. The new techniques will allow the prediction of optimum prestressing levels without compromising the torsional capacity. C1 [Riveros, Guillermo A.; Dixon, DeAnna] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Ayala-Burgos, Jorge L.] US Army, Corps Engineers, Ft Myer, FL 33919 USA. RP Riveros, GA (reprint author), US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Guillermo.A.Riveros@erdc.usace.army.mil; Jose.E.Burgos@usace.army.mil; DeAnna.L.Dixon@erdc.usace.army.mil NR 13 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-3828 EI 1943-5509 J9 J PERFORM CONSTR FAC JI J. Perform. Constr. Facil. PD FEB PY 2017 VL 31 IS 1 DI 10.1061/(ASCE)CF.1943-5509.0000896 PG 9 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA EK9KP UT WOS:000394243700003 ER PT J AU Brager, AJ Mistovich, RJ AF Brager, Allison J. Mistovich, Ronald J. TI GAME TIMES AND HIGHER WINNING PERCENTAGES OF WEST COAST TEAMS OF THE NATIONAL FOOTBALL LEAGUE CORRESPOND WITH REDUCED PREVALENCE OF REGULAR SEASON INJURY SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE performance; fatigue; chronobiology; professional; athlete ID DIURNAL-VARIATION; NEUROBEHAVIORAL PERFORMANCE; ATHLETIC PERFORMANCE; PHYSICAL PERFORMANCE; TEMPERATURE RHYTHMS; CIRCADIAN-RHYTHMS; SWIM PERFORMANCE; MELATONIN; SLEEP AB West coast teams of the National Football League are more statistically likely to win home night games against east coast opponents. The alignment of game times with daily rhythms of alertness is thought to contribute to this advantage. This study aims to determine whether rates of turnovers and injuries during the regular season, putative measures of mental and physical fatigue, impact winning percentages. Regular season schedules and rates of turnovers for each of the 32 teams were obtained from Pro-Football-Reference. We developed our own metric of injury risk for each position obtained from depth charts and regular season schedules. This metric compared cumulative weeks on injury reserve with cumulative time zone travel. West coast teams traveled 4 times as often as east coast teams. However, teams traveling eastward won twice as many games. There was no relationship between the extent and direction of travel and number of turnovers. Losing teams had more turnovers. The offensive and defensive lines in Central Time (CT) were placed on injury reserve 4 times as often as offensive and defensive lines in Pacific Time (PT). Injury prevalence in CT vs. PT was most prominent midseason. Plotting midseason game time relative to biological time revealed that PT teams play games closer to endogenous peaks in alertness, whereas CT teams play games closer to endogenous troughs in alertness. Overall, closer alignment of game time with the endogenous "alerting" signal may protect west coast teams from fatigue-related injuries and suggests for modified strength and conditioning programs. C1 [Brager, Allison J.] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD 20910 USA. [Mistovich, Ronald J.] Case Western Reserve Univ, Sch Med, Dept Orthopaed Surg, Cleveland, OH USA. RP Brager, AJ (reprint author), Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD 20910 USA. EM allison.j.brager.ctr@mail.mil NR 16 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1064-8011 EI 1533-4287 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD FEB PY 2017 VL 31 IS 2 BP 462 EP 467 PG 6 WC Sport Sciences SC Sport Sciences GA EK2OH UT WOS:000393766100027 PM 27893483 ER PT J AU Zoubchenok, D Veillette, M Prevost, J Sanders-Buell, E Wagh, K Korber, B Chenine, AL Finzi, A AF Zoubchenok, Daria Veillette, Maxime Prevost, Jeremie Sanders-Buell, Eric Wagh, Kshitij Korber, Bette Chenine, Agnes L. Finzi, Andres TI Histidine 375 Modulates CD4 Binding in HIV-1 CRF01_AE Envelope Glycoproteins SO JOURNAL OF VIROLOGY LA English DT Article DE HIV-1; CRF01_AE; Env; gp120; Phe43 cavity; CD4; inner domain layers ID HUMAN-IMMUNODEFICIENCY-VIRUS; GP120 INNER DOMAIN; LINEAGE-SPECIFIC DIFFERENCES; REVERSE-TRANSCRIPTASE; CONFORMATIONAL TRANSITIONS; TRANSMEMBRANE GLYCOPROTEIN; NATURAL-HISTORY; IN-VIVO; TYPE-1; INFECTION AB The envelope glycoproteins (Envs) from human immunodeficiency virus type 1 (HIV-1) mediate viral entry. The binding of the HIV-1 gp120 glycoprotein to CD4 triggers conformational changes in gp120 that allow high-affinity binding to its coreceptors. In contrast to all other Envs from the same phylogenetic group, M, which possess a serine (S) at position 375, those from CRF01_AE strains possess a histidine (H) at this location. This residue is part of the Phe43 cavity, where residue 43 of CD4 (a phenylalanine) engages with gp120. Here we evaluated the functional consequences of replacing this residue in two CRF01_AE Envs (CM244 and 92TH023) by a serine. We observed that reversion of amino acid 375 to a serine (H375S) resulted in a loss of functionality of both CRF01_AE Envs as measured by a dramatic loss in infectivity and ability to mediate cell-to-cell fusion. While no effects on processing or trimer stability of these variants were observed, decreased functionality could be linked to a major defect in CD4 binding induced by the replacement of H375 by a serine. Importantly, mutations of residues 61 (layer 1), 105 and 108 (layer 2), and 474 to 476 (layer 3) of the CRF01_AE gp120 inner domain layers to the consensus residues present in group M restored CD4 binding and wild-type levels of infectivity and cell-to-cell fusion. These results suggest a functional coevolution between the Phe43 cavity and the gp120 inner domain layers. Altogether, our observations describe the functional importance of amino acid 375H in CRF01_AE envelopes. IMPORTANCE A highly conserved serine located at position 375 in group M is replaced by a histidine in CRF01_AE Envs. Here we show that H375 is required for efficient CRF01_AE Env binding to CD4. Moreover, this work suggests that specific residues of the gp120 inner domain layers have coevolved with H375 in order to maintain its ability to mediate viral entry. C1 [Zoubchenok, Daria; Veillette, Maxime; Prevost, Jeremie; Finzi, Andres] Univ Montreal, CHUM, Ctr Rech, Montreal, PQ, Canada. [Zoubchenok, Daria; Veillette, Maxime; Prevost, Jeremie; Finzi, Andres] Univ Montreal, Dept Microbiol Infect & Immunol, Montreal, PQ, Canada. [Sanders-Buell, Eric] US Mil, Walter Reed Army Inst Res, HIV Res Program, Silver Spring, MD USA. [Sanders-Buell, Eric; Chenine, Agnes L.] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA. [Wagh, Kshitij; Korber, Bette] Los Alamos Natl Lab, Los Alamos, NM USA. [Finzi, Andres] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ, Canada. RP Finzi, A (reprint author), Univ Montreal, CHUM, Ctr Rech, Montreal, PQ, Canada.; Finzi, A (reprint author), Univ Montreal, Dept Microbiol Infect & Immunol, Montreal, PQ, Canada.; Finzi, A (reprint author), McGill Univ, Dept Microbiol & Immunol, Montreal, PQ, Canada. EM andres.finzi@umontreal.ca FU CIHR foundation grant [352417]; Canada Research Chair on Retroviral Entry; FRQS master award [30888]; CIHR Doctoral Research Award [291485]; Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Design (CHAVI-ID) [AI100645] FX This work was supported by CIHR foundation grant 352417 to A.F. A.F. is the recipient of a Canada Research Chair on Retroviral Entry. D.Z. is the recipient of FRQS master award 30888. M.V. is the recipient of CIHR Doctoral Research Award 291485. K.W. and B.K. were supported by grant AI100645 from the Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Design (CHAVI-ID). Our funding sources had no role in data collection, analysis, or interpretation and were not involved in the writing of the manuscript. We have no conflicts of interest to report. NR 60 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X EI 1098-5514 J9 J VIROL JI J. Virol. PD FEB PY 2017 VL 91 IS 4 AR UNSP e02151 DI 10.1128/JVI.02151-16 PG 14 WC Virology SC Virology GA EK4FU UT WOS:000393883300028 ER PT J AU Chaudhury, S Gromowski, GD Ripoll, DR Khavrutskii, IV Desai, V Wallqvist, A AF Chaudhury, Sidhartha Gromowski, Gregory D. Ripoll, Daniel R. Khavrutskii, Ilja V. Desai, Valmik Wallqvist, Anders TI Dengue virus antibody database: Systematically linking serotype-specificity with epitope mapping in dengue virus SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID PROTEIN DOMAIN-III; CROSS-REACTIVE ANTIBODIES; IN-DEPTH ANALYSIS; ENVELOPE PROTEIN; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; ANTIGENIC DISTANCE; TIME-INTERVAL; B-CELLS; INFECTION AB Background A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a central role in dengue pathogenesis. Primary infections are typically associated with a largely serotype-specific antibody response, while secondary infections show a shift to a broadly cross-reactive antibody response. Methods/Principal findings We hypothesized that the basis for the shift in serotype-specificity between primary and secondary infections can be found in a change in the antibody fine-specificity. To investigate the link between epitope-and serotype-specificity, we assembled the Dengue Virus Antibody Database, an online repository containing over 400 DENV-specific mAbs, each annotated with information on 1) its origin, including the immunogen, host immune history, and selection methods, 2) binding/neutralization data against all four DENV serotypes, and 3) epitope mapping at the domain or residue level to the DENV E protein. We combined epitope mapping and activity information to determine a residue-level index of epitope propensity and cross-reactivity and generated detailed composite epitope maps of primary and secondary antibody responses. We found differing patterns of epitope-specificity between primary and secondary infections, where secondary responses target a distinct subset of epitopes found in the primary response. We found that secondary infections were marked with an enhanced response to cross-reactive epitopes, such as the fusion-loop and E-dimer region, as well as increased cross-reactivity in what are typically more serotype-specific epitope regions, such as the domain I-II interface and domain III. Conclusions/Significance Our results support the theory that pre-existing cross-reactive memory B cells form the basis for the secondary antibody response, resulting in a broadening of the response in terms of cross-reactivity, and a focusing of the response to a subset of epitopes, including some, such as the fusion-loop region, that are implicated in poor neutralization and antibody-dependent enhancement of infection. C1 [Chaudhury, Sidhartha; Ripoll, Daniel R.; Khavrutskii, Ilja V.; Desai, Valmik; Wallqvist, Anders] US Army Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Gromowski, Gregory D.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA. RP Chaudhury, S (reprint author), US Army Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM sidhartha.chaudhury.civ@mail.mil FU U.S. Army Medical Research and Materiel Command; Military Infectious Disease Research Program [Z0010-TC-OC] FX The authors were supported by the U.S. Army Medical Research and Materiel Command (Ft. Detrick, MD) and the Military Infectious Disease Research Program (Grant# Z0010-TC-OC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 58 TC 0 Z9 0 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD FEB PY 2017 VL 11 IS 2 AR e0005395 DI 10.1371/journal.pntd.0005395 PG 17 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA EN1AD UT WOS:000395741700041 ER PT J AU Easterhoff, D Moody, MA Fera, D Cheng, H Ackerman, M Wiehe, K Saunders, KO Pollara, J Vandergrift, N Parks, R Kim, J Michael, NL O'Connell, RJ Excler, JL Robb, ML Vasan, S Rerks-Ngarm, S Kaewkungwal, J Pitisuttithum, P Nitayaphan, S Sinangil, F Tartaglia, J Phogat, S Kepler, TB Alam, SM Liao, HX Ferrari, G Seaman, MS Montefiori, DC Tomaras, GD Harrison, SC Haynes, BF AF Easterhoff, David Moody, M. Anthony Fera, Daniela Cheng, Hao Ackerman, Margaret Wiehe, Kevin Saunders, Kevin O. Pollara, Justin Vandergrift, Nathan Parks, Rob Kim, Jerome Michael, Nelson L. O'Connell, Robert J. Excler, Jean-Louis Robb, Merlin L. Vasan, Sandhya Rerks-Ngarm, Supachai Kaewkungwal, Jaranit Pitisuttithum, Punnee Nitayaphan, Sorachai Sinangil, Faruk Tartaglia, James Phogat, Sanjay Kepler, Thomas B. Alam, S. Munir Liao, Hua-Xin Ferrari, Guido Seaman, Michael S. Montefiori, David C. Tomaras, Georgia D. Harrison, Stephen C. Haynes, Barton F. TI Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial SO PLOS PATHOGENS LA English DT Article ID BROADLY NEUTRALIZING ANTIBODIES; SIMIAN/HUMAN IMMUNODEFICIENCY VIRUS; B-CELL RESPONSES; EFFICACY TRIAL; MONOCLONAL-ANTIBODIES; AFFINITY MATURATION; INFECTION; REPERTOIRE; DESIGN; REPLACEMENT AB The canary pox vector and gp120 vaccine (ALVAC-HIV and AIDSVAX B/E gp120) in the RV144 HIV-1 vaccine trial conferred an estimated 31% vaccine efficacy. Although the vaccine Env AE. A244 gp120 is antigenic for the unmutated common ancestor of V1V2 broadly neutralizing antibody (bnAbs), no plasma bnAb activity was induced. The RV305 (NCT01435135) HIV-1 clinical trial was a placebo-controlled randomized double-blinded study that assessed the safety and efficacy of vaccine boosting on B cell repertoires. HIV-1-uninfected RV144 vaccine recipients were reimmunized 6-8 years later with AIDSVAX B/E gp120 alone, ALVAC-HIV alone, or a combination of ALVAC-HIV and AIDSVAX B/E gp120 in the RV305 trial. Env-specific post-RV144 and RV305 boost memory B cell VH mutation frequencies increased from 2.9% post-RV144 to 6.7% post-RV305. The vaccine was well tolerated with no adverse events reports. While post-boost plasma did not have bnAb activity, the vaccine boosts expanded a pool of envelope CD4 binding site (bs)-reactive memory B cells with long third heavy chain complementarity determining regions (HCDR3) whose germline precursors and affinity matured B cell clonal lineage members neutralized the HIV-1 CRF01 AE tier 2 (difficult to neutralize) primary isolate, CNE8. Electron microscopy of two of these antibodies bound with near-native gp140 trimers showed that they recognized an open conformation of the Env trimer. Although late boosting of RV144 vaccinees expanded a novel pool of neutralizing B cell clonal lineages, we hypothesize that boosts with stably closed trimers would be necessary to elicit antibodies with greater breadth of tier 2 HIV-1 strains. C1 [Easterhoff, David; Moody, M. Anthony; Wiehe, Kevin; Saunders, Kevin O.; Pollara, Justin; Vandergrift, Nathan; Parks, Rob; Alam, S. Munir; Liao, Hua-Xin; Ferrari, Guido; Montefiori, David C.; Tomaras, Georgia D.; Haynes, Barton F.] Duke Univ, Durham, NC 27708 USA. [Fera, Daniela; Harrison, Stephen C.] Harvard Med Sch, Boston Childrens Hosp, Boston, MA USA. [Ackerman, Margaret] Dartmouth Coll, Hanover, NH 03755 USA. [Kim, Jerome; Michael, Nelson L.; Excler, Jean-Louis; Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [O'Connell, Robert J.; Vasan, Sandhya] AFRIMS, US Army Med Directorate, Bangkok, Thailand. [Excler, Jean-Louis] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Nonthaburi, Thailand. [Kaewkungwal, Jaranit] Mahidol Univ, Bangkok, Thailand. [Pitisuttithum, Punnee; Nitayaphan, Sorachai] AFRIMS, Royal Thai Army Component, Bangkok, Thailand. [Sinangil, Faruk] GSID, San Francisco, CA USA. [Tartaglia, James; Phogat, Sanjay] Sanofi Pasteur, Swiftwater, PA USA. [Kepler, Thomas B.] Boston Univ, Boston, MA 02215 USA. [Seaman, Michael S.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA USA. [Kim, Jerome; Excler, Jean-Louis] Int Vaccine Inst, Seoul, South Korea. RP Easterhoff, D; Haynes, BF (reprint author), Duke Univ, Durham, NC 27708 USA. EM david.easterhoff@duke.edu; barton.haynes@duke.edu FU Bill and Melinda Gates Foundation [OPP1033098, OPP1114721]; CA VI MC [OPP1032144]; Duke University Interdisciplinary Research Training Program in HIV/AIDS [5 T32 AI 7392-24]; Duke Center for AIDS Research [AI 064518]; NIH [AI102691, 1F32AI116355, GM62580]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067, W81XWH-11-0174]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067, W81XWH-11-0174]; U.S. National Institute of Allergy and Infectious Diseases through US Army [Y1-AI--2642-17] FX This study was supported by the Bill and Melinda Gates Foundation grant (#OPP1033098 and OPP1114721) (BFH), CA VI MC (OPP1032144) (DCM) http://vww.gatesfoundation.org/; the Duke University Interdisciplinary Research Training Program in HIV/AIDS (5 T32 AI 7392-24) (DE) https://medicine.duke.edu/education-and-training/ fellowship-progams/infectious-diseases/training-and-curriculum-O; Duke Center for AIDS Research (grant number AI 064518) https://cfar.duke.edu/; NIH grants AI102691 (MA) 1F32AI116355 (DF) GM62580 (SCH) https://.www.nih.gov/: and cooperative agreements (W81XWH-07-2-0067 and W81XWH-11-0174) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD) http://www.hmjackson.org/. This research was funded, in part, by the U.S. National Institute of Allergy and Infectious Diseases through an Interagency Agreement with the US Army (Y1-AI--2642-17) https://www.niaid.nih.govi. The views expressed are those of the authors and should not be construed to represent the positions of the Departments of the Army or Defense or the NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 69 TC 0 Z9 0 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD FEB PY 2017 VL 13 IS 2 AR e1006182 DI 10.1371/journal.ppat.1006182 PG 21 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA EO0TL UT WOS:000396410800002 PM 28235027 ER PT J AU Wier, GS Tree, R Nusr, R AF Wier, Grady S. Tree, Rebekah Nusr, Rasha TI Training Effectiveness of a Wide Area Virtual Environment in Medical Simulation SO SIMULATION IN HEALTHCARE-JOURNAL OF THE SOCIETY FOR SIMULATION IN HEALTHCARE LA English DT Article DE Virtual environment; TeamSTEPPS; Air Force Medical Modeling and Simulation Training; DoD; Medical Readiness Training Center; expeditionary medical support; predeployment; training effectiveness; realism; immersive environment ID INTENSIVE-CARE-UNIT; PATIENT SIMULATORS; PSYCHOMOTOR-SKILLS; EDUCATION; PERFORMANCE; EMERGENCY; IMPROVE; METAANALYSIS; TECHNOLOGY; QUALITY AB Introduction: The success of war fighters and medical personnel handling traumatic injuries largely depends on the quality of training they receive before deployment. The purpose of this study was to gauge the utility of a Wide Area Virtual Environment (WAVE) as a training adjunct by comparing and evaluating student performance, measuring sense of realism, and assessing the impact on student satisfaction with their training exposure in an immersive versus a field environment. Methods: This comparative prospective cohort study examined the utility of a three-screen WAVE where subjects were immersed in the training environment with medical simulators. Standard field training commenced for the control group subjects. Medical skills, time to completion, and Team Strategies and Tools to Enhance Performance and Patient Safety objective metrics were assessed for each team (n = 94). In addition, self-efficacy questionnaires were collected for each subject (N = 470). Results: Medical teams received poorer overall teamscores (F-1,F-186 = 0.756, P = 0.001), took longer to complete the scenario (F-1,F-186 = 25.15, P = 0.001), and scored lower on The National Registry of Emergency Medical Technicians trauma assessment checklist (F-1,F-186 = 1.13, P = 0.000) in the WAVE versus the field environment. Critical thinking and realism factors within the self-efficacy questionnaires scored higher in the WAVE versus the field [(F-1,F-466 = 8.04, P = 0.005), (F-1,F-465 = 18.57, P = 0.000), and (F-1,F-466 = 53.24, P = 0.000), respectively]. Conclusions: Environmental and emotional stressors may negatively affect critical thinking and clinical skill performance of medical teams. However, by introducing more advanced simulation trainings with added stressors, students may be able to adapt and overcome barriers to performance found in high-stress environments. C1 [Wier, Grady S.] Axiom Resource Management Inc, Falls Church, VA USA. [Tree, Rebekah] Air Force Med Operat Agcy, Air Force Med Serv Analyt, San Antonio, TX USA. [Tree, Rebekah] TX DCS Corp, Army Res Lab, Aberdeen, MD USA. [Tree, Rebekah] Minist Publ Hlth Doha, Doha, Qatar. RP Wier, GS (reprint author), US Air Force, Air Force Med Serv Analyt, 3515 S Gen McMullen Dr,Bldg 1, San Antonio, TX 78226 USA. EM grady.wier.ctr@us.af.mil FU Defense Health Program 6.7 FX Supported by the Defense Health Program 6.7 via a government grant directly to another government institution (Air Force Medical Modeling and Simulation Training). The approximate amount funded was US $610,000. The authors were employed as government contractors by either ICF International or Engineering and Computer Simulations during the duration of this study. No other relevant financial information to disclose. NR 39 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1559-2332 EI 1559-713X J9 SIMUL HEALTHC JI Simul. Healthc. PD FEB PY 2017 VL 12 IS 1 BP 28 EP 40 DI 10.1097/SIH.0000000000000207 PG 13 WC Health Care Sciences & Services SC Health Care Sciences & Services GA EK5DS UT WOS:000393947700005 PM 28146451 ER PT J AU Just, MG Schafer, JL Hohmann, MG Hoffmann, WA AF Just, Michael G. Schafer, Jennifer L. Hohmann, Matthew G. Hoffmann, William A. TI Wood decay and the persistence of resprouting species in pyrophilic ecosystems SO TREES-STRUCTURE AND FUNCTION LA English DT Article DE Longleaf pine savanna; Phenolics; Quercus laevis; Streamhead pocosin; Wood rot; Wood density ID LONGLEAF PINE ECOSYSTEM; FOREST TREES; CARBON ALLOCATION; TROPICAL FOREST; DECIDUOUS TREES; LIGNIN CONTENT; PLANT TRAITS; FIRE REGIME; RESISTANCE; RESPONSES AB Along a fire frequency gradient, we found a savanna tree species had the greatest below ground decay compartmentalization after coppicing as compared to other resprouting species located at mesic gradient positions. In pyrophilic ecosystems, woody plants are repeatedly injured or topkilled (i.e. aboveground tissue is killed) by frequent fires, and many woody species persist in these systems through resprouting. Yet, many vigorously resprouting plants appear unable to persist in frequently burned landscapes. The success of resprouters has generally been attributed to the ability of these plants to store and remobilize carbohydrate reserves. For resprouting species, persistence might not be determined by resource reserves, but rather by their ability to prevent spread of wood decay after injury, there by maintaining the integrity of belowground organs. We hypothesized that species that persist in frequently burned areas are most capable of containing the extent of wood decay. To this end, we measured variables previously identified to limit the extent of decay in woody plants, including plant size, wood density, and lignin and extractable phenolic concentrations, on five woody species that occur along a fire frequency gradient in the Sandhills physiographic region of North Carolina, USA. We induced topkill by coppicing 19-20 individuals of each species. At 9 and 19 months after coppicing, we harvested the root crowns of half of the individuals per species. We found that the most fire-tolerant species (Quercus laevis) had the least amount of wood decay overall and the greatest wood density and lignin and phenolic concentrations. Q. laevis also had the least decay at both the 9- and 19-month post-coppicing harvest dates. We suggest that wood decay compartmentalization is a potentially overlooked aspect of resprouting success. C1 [Just, Michael G.; Hoffmann, William A.] North Carolina State Univ, Dept Plant & Microbial Biol, Raleigh, NC 27695 USA. [Just, Michael G.] North Carolina State Univ, Dept Entomol & Plant Pathol, Raleigh, NC 27695 USA. [Schafer, Jennifer L.] William Jewell Coll, Dept Biol, Liberty, MO 64068 USA. [Hohmann, Matthew G.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Just, MG (reprint author), North Carolina State Univ, Dept Plant & Microbial Biol, Raleigh, NC 27695 USA.; Just, MG (reprint author), North Carolina State Univ, Dept Entomol & Plant Pathol, Raleigh, NC 27695 USA. EM mjust@ncsu.edu FU US Army Engineer Research and Development Center [W9132T-11-2-0007]; North Carolina State University [W9132T-11-2-0007]; Southeast Climate Science Center fellowship FX We thank A. Ballard, B. Breslow, S. Byerly, D. Metiver, P. Mulvaney, A. Parot, and R. Sanders for research assistance. We wish to thank the Fort Bragg Forestry and Endangered Species branches for logistical support. This research was supported by a cooperative agreement between the US Army Engineer Research and Development Center and North Carolina State University (W9132T-11-2-0007 to W. A. H.). M. G. J. received support from a Southeast Climate Science Center fellowship. NR 87 TC 0 Z9 0 U1 2 U2 2 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0931-1890 EI 1432-2285 J9 TREES-STRUCT FUNCT JI Trees-Struct. Funct. PD FEB PY 2017 VL 31 IS 1 BP 237 EP 245 DI 10.1007/s00468-016-1477-3 PG 9 WC Forestry SC Forestry GA EL0AA UT WOS:000394283900020 ER PT J AU Gonzalez, R Jayakumar, P Iagnemma, K AF Gonzalez, Ramon Jayakumar, Paramsothy Iagnemma, Karl TI Stochastic mobility prediction of ground vehicles over large spatial regions: a geostatistical approach SO AUTONOMOUS ROBOTS LA English DT Article DE NATO Reference Mobility Model (NRMM); Mission planning; Geographical Information Systems (GIS); D* path planner; Statistical sampling ID MONTE-CARLO-SIMULATION; TERRAIN; SLOPE; UNCERTAINTY; MAP; VARIABILITY; NAVIGATION; MODEL; SETS AB This paper describes a stochastic approach to vehicle mobility prediction over large spatial regions [> (km)]. The main source of uncertainty considered in this work derives from uncertainty in terrain elevation, which arises from sampling (at a finer resolution) a Digital Elevation Model. In order to account for such uncertainty, Monte Carlo simulation is employed, leading to a stochastic analysis of vehicle mobility properties. Experiments performed on two real data sets (namely, the Death Valley region and Sahara desert) demonstrate the advantage of stochastic analysis compared to classical deterministic mobility prediction. These results show the computational efficiency of the proposed methodology. The robotic simulator ANVEL has also been used to validate the proposed methodology. C1 [Gonzalez, Ramon] MIT, 77 Massachusetts Ave,Room 35-135a, Cambridge, MA 02139 USA. [Iagnemma, Karl] MIT, 77 Massachusetts Ave,Room 35-237a, Cambridge, MA 02139 USA. [Jayakumar, Paramsothy] US Army RDECOM TARDEC, 6501 E 11 Mile Rd,MS 157,Bldg 215, Warren, MI 48397 USA. RP Gonzalez, R (reprint author), MIT, 77 Massachusetts Ave,Room 35-135a, Cambridge, MA 02139 USA. EM rgonzalez@ual.es; paramsothy.jayakumar.civ@mail.mil; kdi@mit.edu FU US Army TARDEC [W911NF-13-1-0063] FX The research described in this publication was carried out at the Massachusetts Institute of Technology, under the Army Research Project Grant W911NF-13-1-0063 funded by US Army TARDEC. The authors also thank Justin Crawford from Quantum Signal for his support with ANVEL. The authors thank anonymous reviewers for providing useful comments on the paper. NR 49 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0929-5593 EI 1573-7527 J9 AUTON ROBOT JI Auton. Robot. PD FEB PY 2017 VL 41 IS 2 BP 311 EP 331 DI 10.1007/s10514-015-9527-z PG 21 WC Computer Science, Artificial Intelligence; Robotics SC Computer Science; Robotics GA EK3HO UT WOS:000393817500003 ER PT J AU Smith, S Thompson, T Sakamoto, J Allen, JL Baker, DR Wolfenstine, J AF Smith, Sheila Thompson, Travis Sakamoto, Jeff Allen, Jan L. Baker, David R. Wolfenstine, Jeff TI Electrical, mechanical and chemical behavior of Li1.2Zr1.9Sr0.1(PO4)(3) SO SOLID STATE IONICS LA English DT Article ID LITHIUM METAL ANODE; SOLID-ELECTROLYTE; ROOM-TEMPERATURE; IONIC-CONDUCTIVITY; ELASTIC PROPERTIES; THERMAL-EXPANSION; MICROCRACKING; LI7LA3ZR2O12; WATER; AL AB The elastic modulus, fracture toughness, ionic conductivity, Li and water stability of dense (similar to 97%) fine-grain (similar to 10 mu m) Li1.2Zr1.9Sr0.1(PO4)(3) (LZSP) consolidated by reactive hot-pressing was investigated. Low values of elastic modulus (252 and 40.9 GPa), fracture toughness (0.29 and 0.37 MPa-m(1/2)), total conductivity (2.1 x 10(-5) S/cm) at room temperature were exhibited as a result of the presence of microcracks formed during cooling from the hot-pressing temperature. The lattice conductivity of LZSP is 0.85 x 10(-4) S/cm with an activation energy for bulk conductivity of 0.29 eV. The results of Li/LZSP/Li cell impedance as a function of time and surface examination suggest that LZSP is not stable against metallic lithium. The results of the water stability test suggest that LZSP is a possible membrane for use in aqueous Li-Air cells. The results of this study reveal for the case of lithium zirconium phosphates are as follows: 1] a small grain size is required to prevent microcracking to avoid a reduction in total conductivity and mechanical properties and 2] even though they do not contain a transition metal cation they are not stable against Li at room temperature. Published by Elsevier B.V. C1 [Smith, Sheila; Thompson, Travis; Sakamoto, Jeff] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Allen, Jan L.; Baker, David R.; Wolfenstine, Jeff] Army Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Wolfenstine, J (reprint author), Army Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jeffrey.b.wolfenstine.civ@mail.mil FU Army Research Laboratory; U.S. Department of Energy [DE-EE-00006821] FX JW and JAL would like to acknowledge the support of the Army Research Laboratory. This work was supported by the U.S. Department of Energy (DE-EE-00006821). NR 49 TC 0 Z9 0 U1 3 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-2738 EI 1872-7689 J9 SOLID STATE IONICS JI Solid State Ion. PD FEB PY 2017 VL 300 BP 38 EP 45 DI 10.1016/j.ssi.2016.11.032 PG 8 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA EK4WU UT WOS:000393929400006 ER PT J AU Tschopp, MA Gao, F Solanki, KN AF Tschopp, M. A. Gao, F. Solanki, K. N. TI He-V cluster nucleation and growth in alpha-Fe grain boundaries SO ACTA MATERIALIA LA English DT Article DE Helium-vacancy cluster; Grain boundary; Iron; Interstitial; Monovacancy; Formation energy; Binding energy ID MOLECULAR-DYNAMICS; STRUCTURAL-MATERIALS; VACANCY CLUSTERS; BCC IRON; HELIUM; FUSION; DIFFUSION; INTERSTITIALS; EMBRITTLEMENT; DISLOCATIONS AB The nucleation of helium (He) clusters and their growth in a monovacancy (V) eventually leads to the formation of He bubbles on grain boundaries and within the lattice for alpha-Fe, which can cause the macroscopic deterioration of material properties. The research objective herein is to model the nucleation and growth of small He clusters by calculating the formation/binding energetics of a single He atom to a HenV cluster (n = {1-7}) and by capturing how the grain boundary affects this behavior in bcc alpha-Fe. The formation energies for 1-8 He atoms in a monovacancy are calculated at all potential grain boundary sites within 15 A of ten select high angle grain boundaries. These results are combined with previously calculated vacancy formation energies and interstitial He formation energies to quantify how the local grain boundary structure impacts the binding of an interstitial He atom to a HenV cluster. We find that, despite the large range of different local environments within the grain boundaries, it is nearly always energetically favorable for a nearby interstitial He atom to combine with either a monovacancy or a HenV cluster to form a larger HenV cluster, with a binding energy that can be much greater (as much as 100% greater) than in the bulk crystal. Furthermore, a model is presented that captures the formation and binding energies of the various He V clusters while capturing the subsequent binding energies of different clusters/defects in the presence of grain boundaries both of which are important when accounting for the total energetics pertaining to He V cluster growth in the presence of the high angle grain boundaries. Published by Elsevier Ltd on behalf of Acta Materialia Inc. C1 [Tschopp, M. A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Gao, F.] Univ Michigan, Ann Arbor, MI 48109 USA. [Solanki, K. N.] Arizona State Univ, Tempe, AZ 85287 USA. RP Tschopp, MA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM mark.a.tschopp.civ@mail.mil OI Tschopp, Mark/0000-0001-8471-5035 FU U.S. Department of Energy, Office of Fusion Energy Science [DE-AC06-76RLO 1830] FX F.G. is grateful for the support by the U.S. Department of Energy, Office of Fusion Energy Science, under Contract DE-AC06-76RLO 1830. NR 56 TC 0 Z9 0 U1 2 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD FEB 1 PY 2017 VL 124 BP 544 EP 555 DI 10.1016/j.actamat.2016.11.027 PG 12 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA EJ1WK UT WOS:000393000800054 ER PT J AU Fargo, MV Grogan, SP Saguil, A AF Fargo, Matthew V. Grogan, Scott P. Saguil, Aaron TI Evaluation of Jaundice in Adults SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID INDUCED LIVER-INJURY; HEMOLYTIC-ANEMIA; DISEASE; CHOLESTASIS; MECHANISMS; DISORDERS; DIAGNOSIS; PATIENT AB Jaundice in adults can be an indicator of significant underlying disease. It is caused by elevated serum bilirubin levels in the unconjugated or conjugated form. The evaluation of jaundice relies on the history and physical examination. The initial laboratory evaluation should include fractionated bilirubin, a complete blood count, alanine transaminase, aspartate transaminase, alkaline phosphatase, gamma-glutamyltransferase, prothrombin time and/or international normalized ratio, albumin, and protein. Imaging with ultrasonography or computed tomography can differentiate between extrahepatic obstructive and intrahepatic parenchymal disorders. Ultrasonography is the least invasive and least expensive imaging method. A more extensive evaluation may include additional cancer screening, biliary imaging, autoimmune antibody assays, and liver biopsy. Unconjugated hyperbilirubinemia occurs with increased bilirubin production caused by red blood cell destruction, such as hemolytic disorders, and disorders of impaired bilirubin conjugation, such as Gilbert syndrome. Conjugated hyperbilirubinemia occurs in disorders of hepatocellular damage, such as viral and alcoholic hepatitis, and cholestatic disorders, such as choledocholithiasis and neo- plastic obstruction of the biliary tree. Copyright (C) 2017 American Academy of Family Physicians. C1 [Fargo, Matthew V.] Bavaria Med Act, Clin Serv, Vilseck, Germany. [Grogan, Scott P.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Saguil, Aaron] Uniformed Serv Univ Hlth Sci, Recruitment & Adm, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Fargo, MV (reprint author), US Army Med Dept, CMR 411,Box 4384, APO, AE 09112 USA. EM matthew.v.fargo.mil@mail.mil NR 29 TC 0 Z9 0 U1 2 U2 2 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD FEB 1 PY 2017 VL 95 IS 3 BP 164 EP 168 PG 5 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA EJ6XD UT WOS:000393363100008 PM 28145671 ER PT J AU Barstow, C Rice, M McDivitt, JD AF Barstow, Craig Rice, Matthew McDivitt, Jonathan D. TI Acute Coronary Syndrome: Diagnostic Evaluation SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID ACUTE MYOCARDIAL-INFARCTION; AMERICAN-HEART-ASSOCIATION; CHEST-PAIN; PROGNOSTIC VALUE; ARTERY-DISEASE; PRIMARY-CARE; PRACTICE GUIDELINES; PERFUSION SPECT; TASK-FORCE; METAANALYSIS AB Myocardial infarction (MI), a subset of acute coronary syndrome, is damage to the cardiac muscle as evidenced by elevated cardiac troponin levels in the setting of acute ischemia. Coronary artery disease is the leading cause of mortality in the United States. Chest pain is a common presentation in patients with MI; however, there are multiple non cardiac causes of chest pain, and the diagnosis cannot always be made based on initial presentation. The assessment of a possible MI includes evaluation of risk factors and presenting signs and symptoms, rapid electrocardiography, and serum cardiac troponin measurements. A validated risk score, such as the Thrombolysis in Myocardial Infarction score, may also be useful. Electrocardiography should be performed within 10 minutes of presentation. ST elevation MI is diagnosed with ST segment elevation in two contiguous leads on electrocardiography. In the absence of ST segment elevation, non- ST elevation ACS can be diagnosed. An elevated cardiac troponin level is required for diagnosis, and an increase or decrease of at least 20% is consistent with MI. In some patients with negative electrocardiography findings and normal cardiac biomarkers, additional testing may further reduce the likelihood of coronary artery disease. Cardiac catheterization is the standard method for diagnosing coronary artery disease, but exercise treadmill testing, a stress myocardial perfusion study, stress echocardiography, and computed tomography are noninvasive alternatives. Copyright (C) 2017 American Academy of Family Physicians. C1 [Barstow, Craig; Rice, Matthew] Womack Army Med Ctr, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. [McDivitt, Jonathan D.] Naval Hosp, Dept Internal Med, Jacksonville, FL USA. [McDivitt, Jonathan D.] Naval Hosp, Jacksonville, FL USA. RP Barstow, C (reprint author), Womack Army Med Ctr, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. EM craig.h.barstow.mil@mail.mil NR 39 TC 0 Z9 0 U1 1 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X EI 1532-0650 J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD FEB 1 PY 2017 VL 95 IS 3 BP 170 EP 177 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA EJ6XD UT WOS:000393363100009 PM 28145667 ER PT J AU Thomas, DM Paynter, J Peterson, CM Heymsfield, SB Nduati, A Apolzan, JW Martins, CK AF Thomas, Diana M. Paynter, Jonathan Peterson, Courtney M. Heymsfield, Steven B. Nduati, Ann Apolzan, John W. Martins, Corby K. TI A new universal dynamic model to describe eating rate and cumulative intake curves SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE eating rate; food intake; cumulative intake curves; energy intake; satiation; differential equation(s); mathematical model; Universal Eating Monitor; restraint ID FOOD-INTAKE CURVE; MEAL SIZE; BEHAVIOR; CHOLECYSTOKININ; DRINKING; OBESE; WOMEN AB Background: Attempts to model cumulative 'intake curves with quadratic functions have not simultaneously taken gustatory stimulation, satiation, and maximal food intake into account. Objective: Our aim was to develop a dynamic model for cumulative intake curves that captures gustatory stimulation, satiation, and maximal food intake. Design: We developed a first-principles model describing cumulative intake that universally describes gustatory stimulation, satiation, and maximal food intake using 3 key parameters: 1) the initial eating rate, 2) the effective duration of eating, and 3) the maximal food intake. These model parameters were estimated in a study (n = 49) where eating rates were deliberately changed. Baseline data was used to determine the quality of model's fit to data compared with the quadratic model. The 3 parameters were also calculated in a second study consisting of restrained and unrestrained eaters. Finally, we calculated when the gustatory stimulation phase is short or absent. Results: The mean sum squared error for the first-principles model was 337.1 +/- 240.4 compared with 581.6 +/- 563.5 for the quadratic model, or a 43% improvement in fit. Individual comparison demonstrated lower errors for 94% of the subjects. Both sex (P = 0.002) and eating duration (P = 0.002) were associated with the initial eating rate (adjusted R-2 = 0.23). Sex was also associated (P = 0.03 and P = 0.012) with the effective eating duration and maximum food intake (adjusted R-2 = 0.06 and 0.11). In participants directed to eat as much as they could compared with as much as they felt comfortable with, the maximal intake parameter was approximately double the amount. The model found that certain parameter regions resulted in both stimulation and satiation phases, whereas others only produced a satiation phase. Conclusibns: The first-principles model better quantifies interindividual differences in food intake, shows how aspects of food intake differ across subpopulations, and can be applied to determine how eating behavior factors influence total food intake. C1 [Thomas, Diana M.; Paynter, Jonathan] US Mil Acad, West Point, NY 10996 USA. [Peterson, Courtney M.; Heymsfield, Steven B.; Apolzan, John W.; Martins, Corby K.] Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA. [Nduati, Ann] Montclair State Univ, Ctr Quantitat Obes Res, Montclair, NJ USA. RP Thomas, DM (reprint author), US Mil Acad, West Point, NY 10996 USA. EM thomasdia@mail.montclair.edu OI Apolzan, John/0000-0001-8492-7820 FU NIH [R43 HD084277, P30 DK072476, U54 GM104940]; NIH's National Center for Advancing Translational Sciences [KL2TR001419] FX DMT was supported by NIH grant R43 HD084277, and CMP was supported by KL2TR001419 from the NIH's National Center for Advancing Translational Sciences. The work from Pennington Biomedical Research Center was supported by NIH P30 DK072476 and U54 GM104940. NR 30 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD FEB PY 2017 VL 105 IS 2 BP 323 EP 331 DI 10.3945/ajcn.115.127811 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA EJ6SK UT WOS:000393348900007 PM 28077377 ER PT J AU Thomas, DM Westerterp, K AF Thomas, Diana M. Westerterp, Klaas TI Energy balance, energy turnover, and risk of body fat gain SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Letter C1 [Thomas, Diana M.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Westerterp, Klaas] Maastricht Univ, Dept Human Biol, Maastricht, Netherlands. RP Thomas, DM (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM thomasdia@mail.montclair.edu NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD FEB PY 2017 VL 105 IS 2 BP 540 EP 541 DI 10.3945/ajcn.116.141887 PG 2 WC Nutrition & Dietetics SC Nutrition & Dietetics GA EJ6SK UT WOS:000393348900029 PM 28148505 ER PT J AU Harrell, WA Vieira, RC Ensel, SM Montgomery, V Guernieri, R Eccard, VS Campbell, Y Roxas-Duncan, V Cardellina, JH Webb, RP Smith, LA AF Harrell, William A., Jr. Vieira, Rebecca C. Ensel, Susan M. Montgomery, Vicki Guernieri, Rebecca Eccard, Vanessa S. Campbell, Yvette Roxas-Duncan, Virginia Cardellina, John H., II Webb, Robert P. Smith, Leonard A. TI A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Botulinum neurotoxin serotype A; BoNT/A inhibitor; Betti reaction products; Structure-activity relationship; Binding site flexibility ID CLOSTRIDIUM-BOTULINUM; NERVE-TERMINALS; MOTOR NERVES; TOXIN; IDENTIFICATION; TETANUS AB Our initial discovery of 8-hydroxyquinoline inhibitors of BoNT/A and separation/testing of enantiomers of one of the more active leads indicated considerable flexibility in the binding site. We designed a limited study to investigate this flexibility and probe structure-activity relationships; utilizing the Betti reaction, a 36 compound matrix of quinolinol BoNT/A LC inhibitors was developed using three 8-hydroxyquinolines, three heteroaromatic amines, and four substituted benzaldehydes. This study has revealed some of the most effective quinolinol-based BoNT/A inhibitors to date, with 7 compounds displaying IC50 values <= 1 mu M and 11 effective at <= 2 mu M in an ex vivo assay. Published by Elsevier Ltd. C1 [Harrell, William A., Jr.; Vieira, Rebecca C.; Montgomery, Vicki; Guernieri, Rebecca; Eccard, Vanessa S.; Campbell, Yvette; Roxas-Duncan, Virginia; Cardellina, John H., II; Webb, Robert P.] US Army Med Res Inst Infect Dis, Div Mol & Translat Sci, Frederick, MD 21702 USA. [Ensel, Susan M.] Hood Coll, Dept Chem & Phys, Frederick, MD 21701 USA. [Smith, Leonard A.] US Army Med Res Inst Infect Dis, Med Countermeasures Technol, Off Chief Scientist, Frederick, MD 21702 USA. [Harrell, William A., Jr.] Stevenson Univ, Dept Chem, Owings Mills, MD 21117 USA. [Vieira, Rebecca C.] Afton Chem Corp, Richmond, VA 23219 USA. [Eccard, Vanessa S.] Leidos Biomed Res Inc, Frederick, MD 21701 USA. [Roxas-Duncan, Virginia] US Army Med Res Inst Infect Dis, Biosurety Div, Frederick, MD 21702 USA. [Cardellina, John H., II] ReevesGroup, Virginia Beach, VA 23451 USA. RP Webb, RP (reprint author), US Army Med Res Inst Infect Dis, Div Mol & Translat Sci, Frederick, MD 21702 USA. EM robert.p.webb6.civ@mail.mil FU Defense Threat Reduction Agency, Joint Science and Technology Office for Chemical Biological Defense; UMD FX This work was supported by the Defense Threat Reduction Agency, Joint Science and Technology Office for Chemical Biological Defense. We are grateful to E. Brueggemann for mass spectrometry support and Y.F. Lam at UMD for NMR support. NR 23 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X EI 1464-3405 J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD FEB 1 PY 2017 VL 27 IS 3 BP 675 EP 678 DI 10.1016/j.bmcl.2016.11.019 PG 4 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA EJ0LQ UT WOS:000392900600058 PM 28043798 ER PT J AU Ray, JW Seidel, M Husemann, M AF Ray, Jesse W. Seidel, Matthias Husemann, Martin TI A new melanistic variant of the caterpillar hunter Calosoma wilcoxi LeConte, 1848 from Texas, United States of America and a preliminary phylogeny of the genus Calosoma Weber, 1801 (Coleoptera: Carabidae) SO CANADIAN ENTOMOLOGIST LA English DT Article ID THERMAL MELANISM; PRIMERS; BEETLE AB Two aberrant ground beetle (Coleoptera: Carabidae) specimens from the genus Calosoma Weber, 1801 were collected in Waco, Texas, United States of America, in 2012-2013. The specimens, which are morphologically most similar to Calosoma wilcoxi LeConte, 1848, but are dark blue-black instead of the typical metallic green. We employed DNA barcoding and phylogenetic methods to confirm the identities of the aberrant specimens. Preliminary phylogenetic analyses of cytochrome oxidase subunit 1 (COI) sequences of central Texas and southwestern species place the aberrant specimens with 100% confidence as C. wilcoxi. The new variant of C. wilcoxi presumably occurs at low densities. Frequent collecting from 2011 to 2014 resulted in the discovery of only two of the aberrant coloured individuals among hundreds of typical green specimens. These specimens (to our knowledge) represent the first published record of melanistic Calosoma from North America. While the majority of North American species in the genus are naturally black, two of the most widely distributed and abundant species, C. scrutator (Fabricius, 1775) and C. wilcoxi, are typically green. We sequenced the aberrant form as well as all species co-occurring with the new colour morph at the collection locality and used records from GenBank and the Barcode of Life Data System to generate a preliminary phylogeny of the genus, which suggested that some of the currently established subgenera are likely not monophyletic. C1 [Ray, Jesse W.] US Army, Corps Engineers, Los Angeles, CA 90017 USA. [Seidel, Matthias] Natl Museum Prague, Dept Entomol, Cirkusova 1740, CZ-19300 Prague 9, Horni Pocernice, Czech Republic. [Seidel, Matthias; Husemann, Martin] Martin Luther Univ Halle Wittenberg, Gen Zool, Hoher Weg 8, D-06120 Halle, Saale, Germany. [Seidel, Matthias; Husemann, Martin] Univ Hamburg, Ctr Naturkunde CeNak, Martin Luther King Pl 3, D-20146 Hamburg, Germany. RP Husemann, M (reprint author), Martin Luther Univ Halle Wittenberg, Gen Zool, Hoher Weg 8, D-06120 Halle, Saale, Germany.; Husemann, M (reprint author), Univ Hamburg, Ctr Naturkunde CeNak, Martin Luther King Pl 3, D-20146 Hamburg, Germany. EM martinhusemann@yahoo.de NR 27 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0008-347X EI 1918-3240 J9 CAN ENTOMOL JI Can. Entomol. PD FEB PY 2017 VL 149 IS 1 DI 10.4039/tce.2016.28 PG 7 WC Entomology SC Entomology GA EK4HX UT WOS:000393888800001 ER PT J AU Minogue, TD Koehler, JW Norwood, DA AF Minogue, Timothy D. Koehler, Jeffrey W. Norwood, David A. TI Targeted Next-Generation Sequencing for Diagnostics and Forensics SO CLINICAL CHEMISTRY LA English DT Editorial Material C1 [Minogue, Timothy D.; Koehler, Jeffrey W.; Norwood, David A.] US Army, Med Res Inst Infect Dis, USAMRIID, Frederick, MD USA. RP Minogue, TD (reprint author), USAMRIID Ft Detrick, 1425 Porter St, Ft Detrick, MD 21702 USA. EM timothy.d.minogue.civ@mail.mil OI Koehler, Jeffrey/0000-0003-3225-6599 NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 EI 1530-8561 J9 CLIN CHEM JI Clin. Chem. PD FEB PY 2017 VL 63 IS 2 BP 450 EP 452 DI 10.1373/clinchem.2016.256065 PG 3 WC Medical Laboratory Technology SC Medical Laboratory Technology GA EJ6WG UT WOS:000393360000003 PM 27932415 ER PT J AU Carter, SP Greenberg, K Walker, MS AF Carter, Susan Payne Greenberg, Kyle Walker, Michael S. TI The impact of computer usage on academic performance: Evidence from a randomized trial at the United States Military Academy SO ECONOMICS OF EDUCATION REVIEW LA English DT Article ID COLLEGE ACHIEVEMENT; STUDENT-ACHIEVEMENT; PANEL-DATA; TEACHERS; SCHOOLS; INFERENCE; PEER AB We present findings from a study that prohibited computer devices in randomly selected classrooms of an introductory economics course at the United States Military Academy. Average final exam scores among students assigned to classrooms that allowed computers were 0.18 standard deviations lower than exam scores of students in classrooms that prohibited computers. Through the use of two separate treatment arms, we uncover evidence that this negative effect occurs in classrooms where laptops and tablets are permitted without restriction and in classrooms where students are only permitted to use tablets that must remain flat on the desk. Published by Elsevier Ltd. C1 [Carter, Susan Payne; Greenberg, Kyle; Walker, Michael S.] US Mil Acad, 607 Cullum Rd, West Point, NY 10996 USA. RP Greenberg, K (reprint author), US Mil Acad, 607 Cullum Rd, West Point, NY 10996 USA. EM susan.carter@usma.edu; kyle.greenberg@usma.edu; michael.walker2@usma.edu NR 37 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0272-7757 EI 1873-7382 J9 ECON EDUC REV JI Econ. Educ. Rev. PD FEB PY 2017 VL 56 BP 118 EP 132 DI 10.1016/j.econedurev.2016.12.005 PG 15 WC Economics; Education & Educational Research SC Business & Economics; Education & Educational Research GA EJ5FX UT WOS:000393244300010 ER PT J AU Jiang, JL Marathe, AR Keene, JC Taylor, DM AF Jiang, JingLe Marathe, Amar R. Keene, Jennifer C. Taylor, Dawn M. TI A testbed for optimizing electrodes embedded in the skull or in artificial skull replacement pieces used after injury SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE Cranioplasty; Brain monitoring; Skull-embedded electrodes; Brain-machine interface (BMI); Impedance; Electrocorticogram (ECoG); Traumatic brain injury (TBI) ID DEEP BRAIN-STIMULATION; CRANIOPLASTY; IMPLANTS; EPILEPSY; DISEASE; EEG AB Background: Custom-fitted skull replacement pieces are often used after a head injury or surgery to replace damaged bone. Chronic brain recordings are beneficial after injury/surgery for monitoring brain health and seizure development. Embedding electrodes directly in these artificial skull replacement pieces would be a novel, low-risk way to perform chronic brain monitoring in these patients. Similarly, embedding electrodes directly in healthy skull would be a viable minimally-invasive option for many other neuroscience and neurotechnology applications requiring chronic brain recordings. New method: We demonstrate a preclinical testbed that can be used for refining electrode designs embedded in artificial skull replacement pieces or for embedding directly into the skull itself. Options are explored to increase the surface area of the contacts without increasing recording contact diameter to maximize recording resolution. Results: Embedding electrodes in real or artificial skull allows one to lower electrode impedance without increasing the recording contact diameter by making use of conductive channels that extend into the skull. The higher density of small contacts embedded in the artificial skull in this testbed enables one to optimize electrode spacing for use in real bone. Comparison with existing methods: For brain monitoring applications, skull-embedded electrodes fill a gap between electroencephalograms recorded on the scalp surface and the more invasive epidural or subdural electrode sheets. Conclusions: Embedding electrodes into the skull or in skull replacement pieces may provide a safe, convenient, minimally-invasive alternative for chronic brain monitoring. The manufacturing methods described here will facilitate further testing of skull-embedded electrodes in animal models. Published by Elsevier B.V. C1 [Jiang, JingLe; Marathe, Amar R.; Keene, Jennifer C.; Taylor, Dawn M.] Cleveland Clin, Dept Neurosci, Cleveland, OH 44195 USA. [Jiang, JingLe; Marathe, Amar R.; Keene, Jennifer C.; Taylor, Dawn M.] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA. [Jiang, JingLe; Marathe, Amar R.; Keene, Jennifer C.; Taylor, Dawn M.] Louis Stokes VA Med Ctr, Cleveland Funct Elect Stimulat FES Ctr Excellence, Cleveland, OH 44106 USA. [Marathe, Amar R.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Taylor, DM (reprint author), Cleveland Clin, Lerner Res Inst, 9500 Euclid Ave NC30, Cleveland, OH 44195 USA. EM dawn.taylor@case.edu FU National Institutes of Health [NINDS R01NS058871]; China Scholarship Council [2010625038]; Cleveland Clinic FX We would like to thank Ryan Klatte, Dave Dudzinski, and Barry Kuban of the Cleveland Clinic engineering and electronics cores for their assistance in generating the plastic skull models and laser etching the electrodes. We would also like to thank Drs. Andre Machado and Jorge Gonzalez-Martinez for their neurosurgical perspective on practical applications as well as Tina Emancipator, Erin Bynum, Jacob Cox and Loren Schmidt for their surgical assistance and assistance in data collection. Finally, we would like to thank our funding sources: National Institutes of Health NINDS R01NS058871, the China Scholarship Council fellowship No.2010625038, and the Cleveland Clinic. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory, U.S. Department of Veterans Affairs, or U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 37 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 EI 1872-678X J9 J NEUROSCI METH JI J. Neurosci. Methods PD FEB 1 PY 2017 VL 277 BP 21 EP 29 DI 10.1016/j.jneumeth.2016.12.005 PG 9 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA EJ6RL UT WOS:000393346400002 PM 27979758 ER PT J AU Rhon, DI Lentz, TA George, SZ AF Rhon, Daniel I. Lentz, Trevor A. George, Steven Z. TI Unique Contributions of Body Diagram Scores and Psychosocial Factors to Pain Intensity and Disability in Patients With Musculoskeletal Pain SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE catastrophizing; pain diagrams; pain distribution ID LOW-BACK-PAIN; FEAR-AVOIDANCE BELIEFS; PSYCHOLOGICAL DISTRESS; CATASTROPHIZING SCALE; PHYSICAL IMPAIRMENT; ENDURING FREEDOM; PERSISTENT PAIN; IRAQI FREEDOM; RELIABILITY; HEALTH AB STUDY DESIGN: Retrospective cross-sectional cohort of military patients with musculoskeletal pain. BACKGROUND: Body diagrams are used to document symptoms and can also serve as a proxy to assess psychological influence. However, literature to support this is conflicting. OBJECTIVES: To (1) examine the unique contribution of pain and nonpain symptom distribution to magnitude of self-reported pain intensity and disability, and (2) assess the moderating influence of psychological factors and body diagram score on concurrent pain intensity and disability. METHODS: Pain, numbness, and tingling were denoted on a body diagram at initial evaluation. Fear-avoidance beliefs, pain catastrophizing, and region-specific self-reported disability measures were collected. The contributions of pain and nonpain symptom distribution to pain intensity and disability were assessed to determine which body diagram symptom scoring method (pain only, nonpain, or composite) was appropriate for subsequent analyses. Hierarchical linear regression analyses were then used to determine the moderating effects of the Pain Catastrophizing Scaleand Fear-Avoidance Beliefs Questionnaire and the body diagram score on concurrent pain and disability. RESULTS: The Pain Catastrophizing Scale and Fear-Avoidance Beliefs Questionnaire explained between 16% and 17% of the variance in pain intensity, and 8% of variance in disability (all, P<.001). The composite symptom score explained an additional 4% to 5% variance in concurrent disability and pain intensity (all, P<.001). The Pain Catastrophizing Scale moderated the relationship between body diagram score and pain intensity. The positive relationship between composite symptom score and concurrent pain intensity is stronger for patients with low catastrophizing. CONCLUSION: The clinical utility of body diagrams with low symptom distribution may be improved by concomitant assessment of pain catastrophizing and warrants further longitudinal investigation. LEVEL OF EVIDENCE: Symptom prevalence, level 2b. C1 [Rhon, Daniel I.] Brooke Army Med Ctr, Ctr Intrepid, San Antonio, TX USA. [Rhon, Daniel I.] Baylor Univ, Sci Phys Therapy Program, Waco, TX 76798 USA. [Lentz, Trevor A.] Univ Florida, Dept Phys Therapy, Gainesville, FL USA. [Lentz, Trevor A.] Univ Florida, Orthopaed & Sports Med Inst, UF Hlth, Gainesville, FL USA. [George, Steven Z.] Duke Univ, Duke Clin Res Inst, Durham, NC USA. RP Rhon, DI (reprint author), Brooke Army Med Ctr, Ctr Intrepid, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM daniel.i.rhon.mil@mail.mil NR 37 TC 0 Z9 0 U1 0 U2 0 PU J O S P T PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 EI 1938-1344 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD FEB PY 2017 VL 47 IS 2 BP 88 EP 96 DI 10.2519/jospt.2017.6778 PG 9 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA EJ9JB UT WOS:000393541300007 PM 27819193 ER PT J AU Condon, R Allen, C AF Condon, Rachel Allen, Christopher TI Peripheral Nerve Sheath Tumor SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Condon, Rachel; Allen, Christopher] Army Baylor Univ Doctoral Fellowship Orthopaed Ma, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Condon, R (reprint author), Army Baylor Univ Doctoral Fellowship Orthopaed Ma, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU J O S P T PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 EI 1938-1344 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD FEB PY 2017 VL 47 IS 2 BP 124 EP 124 DI 10.2519/jospt.2017.5757 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA EJ9JB UT WOS:000393541300011 PM 28142367 ER PT J AU Kang, YS Rueggeberg, F Ramos, V AF Kang, Young S. Rueggeberg, Frederick Ramos, Van, Jr. TI Effects of chlorine-based and quaternary ammonium-based disinfectants on the wettability of a polyvinyl siloxane impression material SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID WETTING AGENT; CONTACT-ANGLE; SILICONE; CASTS; VOIDS AB Statement of problem. Polyvinyl siloxane (PVS) impression materials must be cold disinfected before cast pouring to prevent cross-contamination among personnel and patients. However, disinfection may affect the ability of PVS impression materials to provide bubble-free stone surfaces because of the removal of surfactants. Purpose. The purpose of this in vitro study was to compare the water contact angles of a PVS impression material treated with either a quaternary ammonium-based (QAB) (DisCide Ultra) or a chlorine-based (CLB) (Dispatch) disinfectant for various exposure times. No disinfection and acetone-immersed (total surfactant removal) specimens were used as positive and negative controls. An additional purpose was to measure changes in the contact angles of the disinfected PVS impression material after applying a topical wetting agent. Material and methods. Flat and disk-shaped PVS specimens (n=5/test condition) were fabricated and subsequently exposed to disinfectants for different times (1 minute, 5 minutes, 30 minutes, 6 hours, and 24 hours). After disinfection, the contact angle with distilled water was determined over a 3-minute period using dynamic contact analysis. The same contact angle measurements were repeated after a wetting agent was applied to the previously disinfected specimens. Contact angles were statistically compared using 2-way ANOVA. The Sidak post hoc test was used to perform pairwise simple contrast and effect comparisons (alpha=.05). Results. The contact angle increased directly with disinfectant contact time. For the CLB product, the contact angle after 30-minute disinfection was not significantly different from that of 1 minute disinfection (P>.05). For the QAB product, exceeding 5-minutes of disinfection resulted in a significantly greater contact angle (P<.001). The application of a wetting agent made the disinfected PVS specimens less hydrophobic. Conclusions. A QAB disinfectant product is more effective at removing surfactant than a CLB disinfectant product. Therefore, a CLB disinfectant provides more working time and control. A wetting agent can reduce the hydrophobicity of a disinfected impression material if the duration of cold disinfection is less than 6 hours. C1 [Kang, Young S.] US Army, Adv Educ Program Gen Dent, Ft Bragg, NC USA. [Rueggeberg, Frederick] Augusta Univ, Dent Coll Georgia, Dept Oral Rehabil, Dent Mat, Augusta, GA USA. [Ramos, Van, Jr.] US Army, Adv Educ Program Prosthodont, Ft Gordon, GA USA. RP Kang, YS (reprint author), 3933 Quarry Hollow Dr, Fayetteville, NC 28306 USA. EM young.s.kang3.mil@mail.mil FU Kerr Corporation FX Supported by Kerr Corporation, which provided impression materials that were tested in this study. NR 21 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3913 EI 1097-6841 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD FEB PY 2017 VL 117 IS 2 BP 266 EP 270 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EJ8AS UT WOS:000393445200012 PM 27765401 ER PT J AU Mayer, JD Skimmyhorn, W AF Mayer, John D. Skimmyhorn, William TI Personality attributes that predict cadet performance at West Point SO JOURNAL OF RESEARCH IN PERSONALITY LA English DT Article DE Broad intelligences; Spatial intelligence; Personal intelligence; Big Five; GPA; Military performance; Personality ID GENERAL MENTAL-ABILITY; EMOTIONAL INTELLIGENCE; COGNITIVE-ABILITIES; LEADER PERFORMANCE; APPLICANT FAKING; JOB-PERFORMANCE; METAANALYSIS; VALIDATION; DIMENSIONS; KNOWLEDGE AB Using data from the United States Military Academy at West Point (N = 1102 and N = 1049) from two successive years, we examined psychological measures of cadets and the correlations of those measures with consequential outcomes such as cadet performance and leadership potential. We examined four broad intelligences, two of which were thing-focused (spatial and mathematical) and two people focused (verbal and personal intelligences) and their predictions to thing- and people-centered courses (e.g., chemistry versus psychology). We found support for a thing-people differential in reasoning. The broad intelligences and the Big Five personality traits also predicted academic and other performance criteria at consequential levels. (C) 2016 Elsevier Inc. All rights reserved. C1 [Mayer, John D.] Univ New Hampshire, Dept Psychol, 15 Acad Way, Durham, NH 03824 USA. [Skimmyhorn, William] US Mil Acad, West Point, NY 10996 USA. [Skimmyhorn, William] Dept Social Sci, Off Econ & Manpower Anal, Bldg 607, West Point, NY 10996 USA. RP Mayer, JD (reprint author), Univ New Hampshire, Dept Psychol, 15 Acad Way, Durham, NH 03824 USA.; Skimmyhorn, W (reprint author), US Mil Acad, West Point, NY 10996 USA. EM jack.mayer@unh.edu; william.skimmyhorn@usma.edu NR 57 TC 0 Z9 0 U1 4 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0092-6566 EI 1095-7251 J9 J RES PERS JI J. Res. Pers. PD FEB PY 2017 VL 66 BP 14 EP 26 DI 10.1016/j.jrp.2016.10.012 PG 13 WC Psychology, Social SC Psychology GA EJ5IE UT WOS:000393250200002 ER PT J AU Lusczek, ER Muratore, SL Dubick, MA Beilman, GJ AF Lusczek, Elizabeth R. Muratore, Sydne L. Dubick, Michael A. Beilman, Greg J. TI Assessment of key plasma metabolites in combat casualties SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Combat casualty care; metabolomics; succinate; hypoxanthine; biomarker ID HEMORRHAGIC-SHOCK; OXIDATIVE STRESS; BASE DEFICIT; INJURY; METABOLOMICS; MORTALITY; TRAUMA; DEATH; HYPOXANTHINE; SPECTROSCOPY AB BACKGROUND: Previous studies have indicated that hemorrhagic shock and injury cause significant early changes in metabolism. Recently, global changes in metabolism have been described using metabolomics in animal models and civilian trauma. We evaluated metabolic changes associated with combat injury to identify early biomarkers and aid in triage. METHODS: Plasma obtained at emergency department presentation and intervals thereafter from patients injured during combat operations in Iraq (n = 78) were compared with healthy control subjects (n = 40). Using proton Nuclear Magnetic Resonance (NMR), water-soluble metabolites were detected and quantified. Resulting metabolic profiles were analyzed with partial least squares discriminant analysis, Receiver Operating Characteristic (ROC), and cluster analyses to identify features of combat injury and mortality. RESULTS: Significant alterations to metabolism resulted from traumatic injury. Metabolic profiles of injured patients differed from those of healthy controls, driven by increased 5-aminolevulinate and hypoxanthine that persisted through 24 hours. Among combat-injured patients, increased succinate and malonate best discriminated between those who survived from those who did not. Higher levels of succinate and hypoxanthine were associated with increased injury severity. ROC analysis showed that these metabolites had equivalent or superior performance to lactate in distinguishing the presence of trauma, injury severity, and mortality. CONCLUSION: Combat injury is associated with several changes at the metabolic level compared with healthy individuals. Novel potential biomarkers of mortality (succinate, malonate), injury severity (succinate, hypoxanthine), and the presence of trauma (hypoxanthine, 5-aminolevulinate) perform as well as or better than the common clinical standard, lactate. (Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.) C1 [Lusczek, Elizabeth R.; Muratore, Sydne L.; Beilman, Greg J.] Univ Minnesota, Dept Surg, Box 242 UMHC, Minneapolis, MN 55455 USA. [Dubick, Michael A.] US Army Inst Surg Res, San Antonio, TX USA. RP Lusczek, ER (reprint author), MMC 195 Mayo,Rm 11-142 PWB,420 Delaware St SE, Minneapolis, MN 55455 USA. EM lusc0006@umn.edu FU US Army Medical Research and Materiel Command; University of Minnesota's Office of the Vice President for Research; Medical School; College of Biological Science; NIH; NSF; Minnesota Medical Foundation FX This study was funded in part by the US Army Medical Research and Materiel Command and performed under a Cooperative Research and Development Agreement between USAISR and the University of Minnesota. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. The authors would like to thank the Minnesota NMR Center for assistance in obtaining NMR spectra. Funding for NMR instrumentation was provided by the University of Minnesota's Office of the Vice President for Research, the Medical School, the College of Biological Science, NIH, NSF, and the Minnesota Medical Foundation. NR 30 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2163-0755 EI 2163-0763 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD FEB PY 2017 VL 82 IS 2 BP 309 EP 316 DI 10.1097/TA.0000000000001277 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA EJ8GO UT WOS:000393463600015 PM 27787435 ER PT J AU Erasmus, JH Auguste, AJ Kaelber, JT Luo, H Rossi, SL Fenton, K Leal, G Kim, DY Chiu, W Wang, T Frolov, I Nasar, F Weaver, SC AF Erasmus, Jesse H. Auguste, Albert J. Kaelber, Jason T. Luo, Huanle Rossi, Shannan L. Fenton, Karla Leal, Grace Kim, Dal Y. Chiu, Wah Wang, Tian Frolov, Ilya Nasar, Farooq Weaver, Scott C. TI A chikungunya fever vaccine utilizing an insect-specific virus platform SO NATURE MEDICINE LA English DT Article ID FORMALDEHYDE INACTIVATION; NONHUMAN-PRIMATES; DENDRITIC CELLS; EILAT VIRUS; ANTIGEN; IMMUNOGENICITY; ALPHAVIRUSES; REPLICATION; DISEASE; ATTENUATION AB Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when compared to inactivated vaccines. In contrast, the inability of inactivated vaccines to replicate enhances safety at the expense of immunogenicity, often necessitating multiple doses and boosters. To overcome these tradeoffs, we developed the insect-specific alphavirus, Eilat virus (EILV), as a vaccine platform. To address the chikungunya fever (CHIKF) pandemic, we used an EILV cDNA clone to design a chimeric virus containing the chikungunya virus (CHIKV) structural proteins. The recombinant EILV/CHIKV was structurally identical at 10 A to wild-type CHIKV, as determined by single-particle cryo-electron microscopy, and it mimicked the early stages of CHIKV replication in vertebrate cells from attachment and entry to viral RNA delivery. Yet the recombinant virus remained completely defective for productive replication, providing a high degree of safety. A single dose of EILV/CHIKV produced in mosquito cells elicited rapid (within 4 d) and long-lasting (>290 d) neutralizing antibodies that provided complete protection in two different mouse models. In nonhuman primates, EILV/CHIKV elicited rapid and robust immunity that protected against viremia and telemetrically monitored fever. Our EILV platform represents the first structurally native application of an insect-specific virus in preclinical vaccine development and highlights the potential application of such viruses in vaccinology. C1 [Erasmus, Jesse H.; Weaver, Scott C.] Univ Texas Med Branch, Inst Translat Sci, Galveston, TX 77555 USA. [Erasmus, Jesse H.; Auguste, Albert J.; Luo, Huanle; Rossi, Shannan L.; Fenton, Karla; Leal, Grace; Wang, Tian; Weaver, Scott C.] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA. [Erasmus, Jesse H.; Auguste, Albert J.; Luo, Huanle; Rossi, Shannan L.; Fenton, Karla; Leal, Grace; Wang, Tian; Weaver, Scott C.] Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA. [Auguste, Albert J.; Rossi, Shannan L.; Weaver, Scott C.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA. [Kaelber, Jason T.; Chiu, Wah] Baylor Coll Med, Natl Ctr Macromol Imaging, Verna & Marrs McLean Dept Biochem & Mol Biol, Houston, TX 77030 USA. [Kaelber, Jason T.; Chiu, Wah] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA. [Kim, Dal Y.; Frolov, Ilya] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA. [Nasar, Farooq] US Army, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA. [Weaver, Scott C.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA. RP Weaver, SC (reprint author), Univ Texas Med Branch, Inst Translat Sci, Galveston, TX 77555 USA.; Weaver, SC (reprint author), Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA.; Weaver, SC (reprint author), Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA.; Weaver, SC (reprint author), Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA.; Weaver, SC (reprint author), Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA. EM sweaver@utmb.edu FU NIH [AI120942, P41GM103832]; Welch Foundation; UTMB Technology Commercialization Program; UTMB McLaughlin Fellowship FX We thank C. Klages and W Lawrence for their technical assistance with the nonhuman primate study, V. Popov and F. Murphy for providing electron microscopy training and discussion, N. Dobias and the UTMB research histology core for assistance with tissue preparations, O. Escaffre for confocal microscopy assistance, and C. Mire for critically reading the manuscript. Support for this work came from NIH grants AI120942 (to S.C.W.), a Welch Foundation grant (to WC.), and a grant from the UTMB Technology Commercialization Program. J.H.E. is supported by a UTMB McLaughlin Fellowship. Electron microscopy was supported by NIH grant P41GM103832 (to WC.). The views expressed in this article are those of the authors and do not reflect the official policy or position of the US Department of Defense, or the Department of the Army. NR 44 TC 0 Z9 0 U1 2 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1078-8956 EI 1546-170X J9 NAT MED JI Nat. Med. PD FEB PY 2017 VL 23 IS 2 BP 192 EP 199 DI 10.1038/nm.4253 PG 8 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA EK2AH UT WOS:000393729000011 PM 27991917 ER PT J AU Schroeder, AL Martinovic-Weigelt, D Ankley, GT Lee, KE Garcia-Reyero, N Perkins, EJ Schoenfuss, HL Villeneuve, DL AF Schroeder, Anthony L. Martinovic-Weigelt, Dalrrla Ankley, Gerald T. Lee, Kathy E. Garcia-Reyero, Natalia Perkins, Edward J. Schoenfuss, Heiko L. Villeneuve, Daniel L. TI Prior knowledge-based approach for associating contaminants with biological effects: A case study in the St. Croix River basin, MN, WI, USA SO ENVIRONMENTAL POLLUTION LA English DT Article DE Contaminants; Chemical mixtures; Chemical-gene interactions; Comparative toxicogenomics database; Adverse outcome pathway ID MINNOWS PIMEPHALES-PROMELAS; HIGH-THROUGHPUT DATA; FATHEAD MINNOWS; GENE-EXPRESSION; WASTE-WATER; ORGANIC MICROPOLLUTANTS; IN-VITRO; MANAGEMENT; MINNESOTA; CHEMICALS AB Evaluating potential adverse effects of complex chemical mixtures in the environment is challenging. One way to address that challenge is through more integrated analysis of chemical monitoring and biological effects data. In the present study, water samples from five locations near two municipal wastewater treatment plants in the St. Croix River basin, on the border of MN and WI, USA, were analyzed for 127 organic contaminants. Known chemical-gene interactions were used to develop site specific knowledge assembly models (KAMs) and formulate hypotheses concerning possible biological effects associated with chemicals detected in water samples from each location. Additionally, hepatic gene expression data were collected for fathead minnows (Pimephales promelas) exposed in situ, for 12 d, at each location. Expression data from oligonucleotide microarrays were analyzed to identify functional annotation terms enriched among the differentially-expressed probes. The general nature of many of the terms made hypothesis formulation on the basis of the transcriptome-level response alone difficult. However, integrated analysis of the transcriptome data in the context of the site-specific KAMs allowed for evaluation of the likelihood of specific chemicals contributing to observed biological responses. Thirteen chemicals (atrazine, carbamazepine, metformin, thiabendazole, diazepam, cholesterol, p-cresol, phenytoin, omeprazole, ethyromycin, 17 beta-estradiol, cimetidine, and estrone), for which there was statistically significant concordance between occurrence at a site and expected biological response as represented in the KAM, were identified. While not definitive, the approach provides a line of evidence for evaluating potential cause-effect relationships between components of a complex mixture of contaminants and biological effects data, which can inform subsequent monitoring and investigation. Published by Elsevier Ltd. C1 [Schroeder, Anthony L.] Univ Minnesota Twin Cities, Water Resources Ctr, 1985 Lower Buford Circle, St Paul, MN 55108 USA. [Schroeder, Anthony L.; Ankley, Gerald T.; Villeneuve, Daniel L.] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55804 USA. [Martinovic-Weigelt, Dalrrla] Univ St Thomas, Dept Biol, Mail OWS 390,2115 Summit Ave, St Paul, MN 55105 USA. [Lee, Kathy E.] US Geol Survey, Tox Subst Hydrol Program, Grand Rapids, MN 55744 USA. [Garcia-Reyero, Natalia; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS 39762 USA. [Schoenfuss, Heiko L.] Cloud State Univ, Aquat Toxicol Lab, WSB 273, St Cloud, MN 56301 USA. RP Villeneuve, DL (reprint author), US EPA, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM Villeneuve.dan@epa.gov OI Schoenfuss, Heiko/0000-0001-5464-992X FU USGS; National Science Foundation [CBET-1336062/1336165/1336604]; National Park Service Water Quality Partnership Program, US EPA (Office of Research and Development's Chemical Safety for Sustainability Research Program); National Park Service Water Quality Partnership Program, US EPA (Region 5, Great Lakes National Program Office) FX Support by the USGS and National Park Service Water Quality Partnership Program, US EPA (Office of Research and Development's Chemical Safety for Sustainability Research Program, and Region 5, Great Lakes National Program Office), and National Science Foundation (CBET-1336062/1336165/1336604 to DM-W). We thank Sarah Elliott, Jeffery Ziegeweid, and Brent Mason at USGS for their field support; and Byron Karns at NPS for logistical support. We thank Maya Peters, Jackie Heitzman, Abigail Lukowicz, Evan Eid, Kyle Stevens, Jenna Cavallin, Megan Hughes, Krysta Nelson, Rebecca Milsk, Travis Saari, and Eric Randolph for help with network development. We thank Lynn Escalon for microarray analysis. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. The contents neither constitute, nor necessarily reflect, US EPA policy. Permission was granted by the Chief of Engineers to publish this information. NR 40 TC 0 Z9 0 U1 13 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 EI 1873-6424 J9 ENVIRON POLLUT JI Environ. Pollut. PD FEB PY 2017 VL 221 BP 427 EP 436 DI 10.1016/j.envpol.2016.12.005 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA EI8OV UT WOS:000392767900045 PM 27939634 ER PT J AU Hoover, JJ Zielinski, DP Sorensen, PW AF Hoover, J. J. Zielinski, D. P. Sorensen, P. W. TI Swimming performance of adult bighead carp Hypophthalmichthys nobilis (Richardson, 1845) and silver carp H.molitrix (Valenciennes, 1844) SO JOURNAL OF APPLIED ICHTHYOLOGY LA English DT Article ID UPPER MISSISSIPPI RIVER; LAKE STURGEON; PADDLEFISH; MOVEMENT; HABITAT; BARRIERS; PASSAGE; TUNNEL; SPEEDS; FLOW AB Although the movement of invasive bighead carp (Hypophthalmichthys nobilis) and silver carp (H.molitrix) in the Upper Mississippi River system is dependent on their ability to swim through its numerous lock-and-dams, the swimming performance of adults of these species is at present unknown. Using a large (2,935-L) mobile swim tunnel, the swimming performance of adult bighead and adult silver carp was quantified at water velocities that challenged them to exhibit either prolonged and/or burst swimming (76-244cm/s) with fatigue times of less than 10min. Simple log-linear models best described the relative swim speed to fatigue relationships for both species. Under these conditions, the swimming performances of adult bighead and silver carp were similar to several species of adult fishes native to the Mississippi River system, but relatively low (<3 total body lengths per second, TL/s) compared to previously studied juveniles and sub-adult bigheaded carps (3-15TL/s). The decline in endurance with water velocity was three times greater in bighead carp (slope=-2.98) than in silver carp (slope=-1.01) and the predictive ability of the bighead model was appreciably better than the silver carp model. The differences in adult swimming performance between the two species were coincident with behavioral differences (e.g. breaching in silver carp but not in bighead carp). The swimming performance data of adult bighead and silver carp can now be used to evaluate whether their passage through manmade river structures including the gates of lock-and-dams in the Upper Mississippi River might be reduced. C1 [Hoover, J. J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. [Zielinski, D. P.; Sorensen, P. W.] Univ Minnesota, Minnesota Aquat Invas Species Res Ctr, Dept Fisheries Wildlife & Conservat Biol, St Paul, MN 55108 USA. RP Zielinski, DP (reprint author), Univ Minnesota, Minnesota Aquat Invas Species Res Ctr, Dept Fisheries Wildlife & Conservat Biol, St Paul, MN 55108 USA. EM ziel0064@umn.edu FU Minnesota Environmental and Natural Resources Trust Fund FX Fish were collected by W.E. Lancaster under scientific collecting permit # 1205141, Mississippi Department of Wildlife Fisheries and Parks. Assistance in the field was provided by J.A. Collins, S.G. George, N.M. Hahn, A.W. Katzenmeyer, K.J. Killgore, B.R. Lewis, and W.T. Slack. Site access and logistic support were provided by property owners Wade and Betsy Creekmore. Statistical analyses and advice on model interpretation were provided by C.E. Murphy. Handling of fish was in accordance with experimental protocol # EL-5036-2015-1, Field Studies of Swimming Performance of Large Riverine Fishes, approved by the US Army Engineer Research and Development Center Environmental Laboratory (ERDC-EL) Institutional Animal Care and Use Committee (IACUC) which is accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care International (AAALAC). This study was funded by the Minnesota Environmental and Natural Resources Trust Fund as recommended by the Legislative-Citizen Commission on Minnesota Resources (LCCMR). Permission to publish was provided by the Chief of Engineers. NR 38 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0175-8659 EI 1439-0426 J9 J APPL ICHTHYOL JI J. Appl. Ichthyol. PD FEB PY 2017 VL 33 IS 1 BP 54 EP 62 DI 10.1111/jai.13199 PG 9 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA EJ4GU UT WOS:000393175700008 ER PT J AU Fitzhugh, D Moses, C Kilby, R Ward, L AF Fitzhugh, Dawn Moses, Chris Kilby, Rebecca Ward, Lindsey TI Defining "access" SO LAB ANIMAL LA English DT Editorial Material C1 [Fitzhugh, Dawn; Moses, Chris; Kilby, Rebecca; Ward, Lindsey] US Army, Edgewood, MD 21040 USA. RP Fitzhugh, D (reprint author), US Army, Edgewood, MD 21040 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0093-7355 EI 1548-4475 J9 LAB ANIMAL JI Lab Anim. PD FEB PY 2017 VL 46 IS 2 BP 36 EP 36 PG 1 WC Veterinary Sciences SC Veterinary Sciences GA EJ0ME UT WOS:000392902200010 PM 28106869 ER PT J AU Kofoed, MS AF Kofoed, Michael S. TI To Apply or Not to Apply: FAFSA Completion and Financial Aid Gaps SO RESEARCH IN HIGHER EDUCATION LA English DT Article DE Student financial aid; FAFSA completion; Economics of higher education; Propensity score matching ID ECONOMETRIC EVALUATION ESTIMATOR; HIGHER-EDUCATION; ENROLLMENT; STUDENTS; SCHOOL; PERSISTENCE; MINORITY; PROGRAM; CHOICE; IMPACT AB In the United States, college students must complete the Free Application for Student Federal Aid (FAFSA) to access federal aid. However, many eligible students do not apply and consequently forgo significant amounts of financial aid. If students have perfect information about aid eligibility, we would expect that all eligible students complete FAFSA and no aid would go unclaimed. Using data from the National Postsecondary Student Aid Survey, I estimate a multinomial logit model which controls for all variables that contribute to aid eligibility and other student characteristics that may deter FAFSA completion. I find that students who are lower middle income, white, male and independent from parents are less likely to complete FAFSA even when they are eligible for aid. Using propensity score matching, I find that each year applicants forgo $9,741.05 in total aid (including grant and loan aid) which includes $1,281.00 of Pell Grants, $2,439.50 of the balance subsidized student loans, $1,986.65 of the balance of unsubsidized student loans, and $1,016.04 of institutional grants. These aid totals aggregate to $24 billion annually. C1 [Kofoed, Michael S.] US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA. RP Kofoed, MS (reprint author), US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA. EM michael.kofoed@usma.edu FU Graduate School of the University of Georgia FX I thank David Mustard, Christopher Cornwell, Ian Schmutte, Jonathan Williams, and Michael Walker for helpful comments and advice. This research benefited from a Summer Dissertation Fellowship sponsored by the Graduate School of the University of Georgia. I also appreciate the comments of seminar and conference participants at the University of Georgia, City University of New York, the Association of Education Finance and Policy, the Southern Economic Association, and the Midwestern Economic Association. NR 48 TC 0 Z9 0 U1 3 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-0365 EI 1573-188X J9 RES HIGH EDUC JI Res. High. Educ. PD FEB PY 2017 VL 58 IS 1 BP 1 EP 39 DI 10.1007/s11162-016-9418-y PG 39 WC Education & Educational Research SC Education & Educational Research GA EJ3MH UT WOS:000393115800001 ER PT J AU Paramore, JD Fang, ZGZ Dunstan, M Sun, P Butler, BG AF Paramore, James D. Fang, Zhigang Zak Dunstan, Matthew Sun, Pei Butler, Brady G. TI Hydrogen-enabled microstructure and fatigue strength engineering of titanium alloys SO SCIENTIFIC REPORTS LA English DT Article ID PHASE-TRANSFORMATION HSPT; POWDER-METALLURGY METHOD; TI-6AL-4V POWDERS; TI; DIFFUSION AB Traditionally, titanium alloys with satisfactory mechanical properties can only be produced via energy-intensive and costly wrought processes, while titanium alloys produced using low-cost powder metallurgy methods consistently result in inferior mechanical properties, especially low fatigue strength. Herein, we demonstrate a new microstructural engineering approach for producing low-cost titanium alloys with exceptional fatigue strength via the hydrogen sintering and phase transformation (HSPT) process. The high fatigue strength presented in this work is achieved by creating wrought-like microstructures without resorting to wrought processing. This is accomplished by generating an ultrafine-grained as-sintered microstructure through hydrogen-enabled phase transformations, facilitating the subsequent creation of fatigue-resistant microstructures via simple heat treatments. The exceptional strength, ductility, and fatigue performance reported in this paper are a breakthrough in the field of low-cost titanium processing. C1 [Paramore, James D.; Fang, Zhigang Zak; Dunstan, Matthew; Sun, Pei] Univ Utah, Dept Met Engn, 135 South 1460 East Room 412, Salt Lake City, UT 84112 USA. [Paramore, James D.; Butler, Brady G.] US Army, Res Lab, Lightweight & Specialty Met Branch, 4600 Deer Creek Loop RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP Paramore, JD; Fang, ZGZ (reprint author), Univ Utah, Dept Met Engn, 135 South 1460 East Room 412, Salt Lake City, UT 84112 USA.; Paramore, JD (reprint author), US Army, Res Lab, Lightweight & Specialty Met Branch, 4600 Deer Creek Loop RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. EM james.d.paramore.ctr@mail.mil; zak.fang@utah.edu FU US Department of Energy (US DOE), Innovative Manufacturing Initiative, through the Advanced Manufacturing Office [DEEE0005761]; US Department of Energy (US DOE), Innovative Manufacturing Initiative, through Office of Energy Efficiency and Renewable Energy [DEEE0005761]; US DOE [DE-AC02-06CH11357] FX The authors acknowledge funding support by the US Department of Energy (US DOE), Innovative Manufacturing Initiative (DEEE0005761), through the Advanced Manufacturing Office and the Office of Energy Efficiency and Renewable Energy. Additionally, this research was supported in part by an appointment to the Postgraduate Research Participation Program at the US Army Research Laboratory (USARL) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US DOE and USARL. Use of the Advanced Photon Source (APS), an Office of Science User Facility operated for the US DOE Office of Science by Argonne National Laboratory (ANL), was supported by the US DOE under Contract No. DE-AC02-06CH11357. The authors wish to thank James Catalano, Jonathan Ligda, Micah Gallagher, and David Runk of USARL for help in polishing and etching metallographic samples, and for machining many of the tensile and fatigue bars used in this study. The authors acknowledge the valuable help of Dr. Yang Ren during synchrotron X-ray experiments at APS. Raw materials were provided by Reading Alloys (AMETEK). NR 43 TC 0 Z9 0 U1 2 U2 2 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD FEB 1 PY 2017 VL 7 AR 41444 DI 10.1038/srep41444 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EJ4DM UT WOS:000393166300001 PM 28145527 ER PT J AU Liu, NT Salter, MG Khan, MN Branson, RD Enkhbaatar, P Kramer, GC Salinas, J Marques, NR Kinsky, MP AF Liu, Nehemiah T. Salter, Michael G. Khan, Muzna N. Branson, Richard D. Enkhbaatar, Perenlei Kramer, George C. Salinas, Jose Marques, Nicole R. Kinsky, Michael P. TI CLOSED-LOOP CONTROL OF FIO2 RAPIDLY IDENTIFIES NEED FOR RESCUE VENTILATION AND REDUCES ARDS SEVERITY IN A CONSCIOUS SHEEP MODEL OF BURN AND SMOKE INHALATION INJURY SO SHOCK LA English DT Article DE Acute respiratory distress syndrome; autonomous critical care; closed-loop controllers; conscious sheep; inhalation injury; trauma ID ACUTE LUNG INJURY; PROSPECTIVE RANDOMIZED CROSSOVER; RESPIRATORY-DISTRESS-SYNDROME; LIFESAVING INTERVENTIONS; TRAUMA PATIENTS; VITAL SIGNS; MECHANICAL VENTILATION; EMERGENCY-DEPARTMENTS; MULTIPLE HEMORRHAGES; AUTONOMOUS CONTROL AB Pulmonary injury can be characterized by an increased need for fraction of inspired oxygen or inspired oxygen percentage (FiO(2)) to maintain arterial blood saturation of oxygenation (SaO(2)). We tested a smart oxygenation system (SOS) that uses the activity of a closed-loop control FiO(2) algorithm (CLC-FiO(2)) to rapidly assess acute respiratory distress syndrome (ARDS) severity so that rescue ventilation (RscVent) can be initiated earlier. After baseline data, a pulse-oximeter (noninvasive saturation of peripheral oxygenation [SpO(2)]) was placed. Sheep were then subjected to burn and smoke inhalation injury and followed for 48 h. Initially, sheep were spontaneously ventilating and then randomized to standard of care (SOC) (n = 6), in which RscVent began when partial pressure of oxygen (PaO2) <90 mmHg or FiO(2) < 0.6, versus SOS (n = 7), software that incorporates and displays SpO(2), CLC-FiO(2), and SpO(2)/CLC-FiO(2) ratio, at which RscVent was initiated when ratio threshold < 250. RscVent was achieved using a G5 Hamilton ventilator (Bonaduz, Switzerland) with adaptive pressure ventilation and adaptive support ventilation modes for SOC and SOS, respectively. Outcomes: the time difference from when SpO(2)/FiO(2) < 250 to RscVent initiation was 4.7 +/- 0.6 h and 0.2 +/- 0.1 h, SOC and SOS, respectively (P < 0.001). Oxygen responsiveness after RscVent, defined as SpO(2)/FiO(2) > 250 occurred in 4/7, SOS and 0/7, SOC. At 48 h the SpO(2)/FiO(2) ratio was 104 +/- 5 in SOC versus 228 +/- 59 in SOS (P = 0.036). Ventilatory compliance and peak airway pressures were significantly improved with SOS versus SOC (P<0.001). Data suggest that SOS software, e.g. SpO(2)/CLC-FiO(2) ratio, after experimental ARDS can provide a novel continuous index of pulmonary function that is apparent before other clinical symptoms. Earlier initiation of RscVent translates into improved oxygenation (reduces ARDS severity) and ventilation. C1 [Liu, Nehemiah T.; Salinas, Jose] US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. [Salter, Michael G.; Khan, Muzna N.; Enkhbaatar, Perenlei; Kramer, George C.; Marques, Nicole R.; Kinsky, Michael P.] Univ Texas Med Branch, Dept Anesthesiol, Resuscitat Res Lab, Galveston, TX 77555 USA. [Branson, Richard D.] Univ Cincinnati, Dept Surg, Crit Care Res, 231 Bethesda Ave, Cincinnati, OH 45267 USA. RP Liu, NT (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.; Kinsky, MP (reprint author), Univ Texas Med Branch, 301 Univ Blvd, Galveston, TX 77555 USA. EM nehemiah.liu@us.army.mil; mkinsky@utmb.edu FU U.S. Army Combat Casualty Care Research Program under U.S. Army Grant [W81XWH-12-1-0598] FX This work was supported by the U.S. Army Combat Casualty Care Research Program under U.S. Army Grant # W81XWH-12-1-0598. NR 30 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD FEB PY 2017 VL 47 IS 2 BP 200 EP 207 DI 10.1097/SHK.0000000000000686 PG 8 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA EI9FN UT WOS:000392813300011 PM 27392155 ER PT J AU Chen, J Wu, XW Keesee, J Liu, B Darlington, DN Cap, AP AF Chen, Jacob Wu, Xiaowu Keesee, Jeffrey Liu, Bin Darlington, Daniel N. Cap, Andrew P. TI LIMITED RESUSCITATION WITH FRESH OR STORED WHOLE BLOOD CORRECTS CARDIOVASCULAR AND METABOLIC FUNCTION IN A RAT MODEL OF POLYTRAUMA AND HEMORRHAGE SO SHOCK LA English DT Article DE aPTT; clotting firmness; coagulation; cold storage; fibrinogen; hemorrhage; platelets; polytrauma; PT; resuscitation ID ACUTE TRAUMATIC COAGULOPATHY; DAMAGE CONTROL RESUSCITATION; IMPROVED SURVIVAL; PLATELET-FUNCTION; COMBAT TRAUMA; AWAKE RATS; TRANSFUSION; COAGULATION; STORAGE; TIME AB Introduction: We have recently shown that human whole blood stored at 4 degrees C maintains hemostatic and platelet function. In this study, we compared restoration of hemodynamic, metabolic and hemostatic function after limited resuscitation with rat fresh whole blood, rat stored whole blood, or Lactated Ringers in traumatized rats. Methods: Rat whole blood was stored for 10 days at 4 degrees C for evaluation of hemostatic function. Polytrauma was performed on isoflurane-anesthetized Sprague-Dawley rats (350-450 g) by damage to the intestines, liver, right leg skeletal muscle, and right femur fracture, followed by 40% hemorrhage. At 1 h, rats were resuscitated (20%) with either fresh whole blood (FWB), stored whole blood, 4 degrees C for 7 days (SWB), Lactated Ringers (LR), or nothing. Blood samples were taken before and 2 h after trauma and hemorrhage to evaluate metabolic and hemostatic function. Results: Whole blood stored for 10 days showed a significant prolongation in prothrombin time (PT) and activated partial thromboplastin time (aPTT), and fall in fibrinogen concentration, but no change in Maximum Clot Firmness or speed of clot formation. Platelet function was maintained until day 7 in storage, than fell significantly. Polytrauma and hemorrhage in rats led to a fall in arterial pressure, plasma bicarbonate, fibrinogen, and platelet function, and a rise in plasma lactate, PT, aPTT, and creatinine. Resuscitation with either FWB or 7 day SWB, but not LR, returned arterial pressure, plasma lactate and plasma bicarbonate to levels similar to control, but had no effect on the fall in fibrinogen or platelet function, or the rise in PT, aPTT, or creatinine. Conclusion: Hemostatic and platelet function of rat whole blood stored at 4 degrees C is preserved for at least 7 days in vitro. Low volume resuscitation with SWB or FWB, but not LR, restores hemodynamic and metabolic function, but not the coagulopathy after severe trauma and hemorrhage. C1 [Chen, Jacob] Israeli Def Forces, Jerusalem, Israel. [Chen, Jacob; Wu, Xiaowu; Keesee, Jeffrey; Liu, Bin; Darlington, Daniel N.; Cap, Andrew P.] US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. [Wu, Xiaowu; Darlington, Daniel N.; Cap, Andrew P.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. RP Darlington, DN (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM daniel.n.darlington.civ@mail.mil FU US Army Medical Research Material Command FX US Army Medical Research Material Command. NR 43 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1073-2322 EI 1540-0514 J9 SHOCK JI Shock PD FEB PY 2017 VL 47 IS 2 BP 208 EP 216 DI 10.1097/SHK.0000000000000748 PG 9 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA EI9FN UT WOS:000392813300012 PM 27648698 ER PT J AU Videen, G Sun, WB Gong, W AF Videen, Gorden Sun, Wenbo Gong, Wei TI Advances in atmospheric light scattering theory and remote-sensing techniques SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Editorial Material C1 [Videen, Gorden] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Videen, Gorden] Space Sci Inst, 4750 Walnut St,Boulder Suite 205, Boulder, CO 80301 USA. [Sun, Wenbo] Sci Syst & Applicat Inc, Hampton, VA 23666 USA. [Gong, Wei] Wuhan Univ, State Key Lab Informat Engn Surveying Mapping & R, Wuhan 430079, Hubei, Peoples R China. EM gorden.w.videen.civ@mail.mil; wenbo.sun-1@nasa.gov; weigong@lmars.whu.edu.cn NR 29 TC 0 Z9 0 U1 7 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD FEB PY 2017 VL 188 SI SI BP 1 EP 2 DI 10.1016/j.jqsrt.2016.12.017 PG 2 WC Optics; Spectroscopy SC Optics; Spectroscopy GA EI5WF UT WOS:000392566300001 ER PT J AU Doughty, DC Hill, SC AF Doughty, David C. Hill, Steven C. TI Automated aerosol Raman spectrometer for semi-continuous sampling of atmospheric aerosol SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE Raman Spectroscopy; Aerosol; HULLS/Soot ID CHEMICAL-COMPOSITION; PARTICULATE MATTER; MIXING STATE; AIR-POLLUTION; FUNGAL SPORES; BLACK CARBON; PARTICLES; SPECTROSCOPY; MICROSPECTROSCOPY; IDENTIFICATION AB Raman spectroscopy (RS) is useful in characterizing atmospheric aerosol. It is not commonly used in studying ambient particles partly because automated instrumentation for aerosol RS has not been available. Battelle (Columbus, Ohio, USA) has developed the Resource Effective Bioidentification System (REBS) for automated detection of airborne bioagents based on RS. We use a version of the REBS that measures Raman spectra of one set of particles while the next set of particles is collected from air, then moves the newly collected particles to the analysis region and repeats. Here we investigate the use of the REBS as the core of a general-purpose automated Aerosol Raman Spectrometer (ARS) for atmospheric applications. This REBS-based ARS can be operated as a line-scanning Raman imaging spectrometer. Spectra measured by this ARS for single particles made of polystyrene, black carbon, and several other materials are clearly distinguishable. Raman spectra from a 15 min ambient sample (approximately 35-50 particles, 158 spectra) were analyzed using a hierarchical clustering method to find that the cluster spectra are consistent with soot, inorganic aerosol, and other organic compounds. The ARS ran unattended, collecting atmospheric aerosol and measuring spectra for a 7 hr period at 15-min intervals. A total of 32,718 spectra were measured; 5892 exceeded a threshold and were clustered during this time. The number of particles exhibiting the D-G bands of amorphous carbon plotted vs time (at 15-min intervals) increases during the morning commute, then decreases. This data illustrates the potential of the ARS to measure thousands of time resolved aerosol Raman spectra in the ambient atmosphere over the course of several hours. The capability of this ARS for automated measurements of Raman spectra should lead to more extensive RS-based studies of atmospheric aerosols. Published by Elsevier Ltd. C1 [Doughty, David C.; Hill, Steven C.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM david.c.doughty2.civ@mail.mil FU US Army Research Laboratory mission funds, Atmospheric Science Center; Meteorological Sensor Array FX This work was supported by US Army Research Laboratory mission funds as part of the Atmospheric Science Center and the Meteorological Sensor Array. Two anonymous reviewers provided feedback which significantly helped improve the quality of this manuscript. NR 61 TC 2 Z9 2 U1 8 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD FEB PY 2017 VL 188 SI SI BP 103 EP 117 DI 10.1016/j.jqsrt.2016.06.042 PG 15 WC Optics; Spectroscopy SC Optics; Spectroscopy GA EI5WF UT WOS:000392566300013 ER PT J AU Kelley, AM MacDonnell, J Grigley, D Campbell, J Gaydos, SJ AF Kelley, Amanda M. MacDonnell, Jason Grigley, Deahndra Campbell, John Gaydos, Steven J. TI Reported Back Pain in Army Aircrew in Relation to Airframe, Gender, Age, and Experience SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE LA English DT Article DE gender; flight experience; rotary-wing aviators ID MILITARY HELICOPTER PILOTS; WHOLE-BODY VIBRATION; IN-FLIGHT AB INTRODUCTION: Back pain has remained an issue of significance among aircraft crewmembers for decades, occurring in the majority of military helicopter pilots with potential deleterious effects on performance, safety, and operational readiness. This exploratory, correlational survey study was designed to evaluate the presence of patterns and relationships that may require further examination to understand causal factors. METHODS: The study population consisted of U.S. Army aviation crewmembers. Subjects (467) completed an anonymous survey, including questions regarding demographics, airframes, experience, pain history and severity, ergonomics, mitigation strategies, and duty limitations. RESULTS: Overall, 84.6% of participants reported back pain at some time during their flying career, with 77.8% reporting back pain in the last calendar year. Age was found to significantly correlate with earlier time to pain during flight, higher pain rating after flight, and occurrence of grounding. A stepwise linear regression model was used to explore the relationships between age, flight hours, and years of aviation experience, demonstrating age to be the significant variable accounting for the observed variance. Aircrew reported wear of combat-related survival equipment and poor lumbar support to be the most notable contributors. DISCUSSION: Back pain rates were consistent with previous studies.The relationship of age to back pain in this study may highlight unique pathophysiological pathways that should be further investigated within an occupational context to better understand the etiologic role. Enhanced seated lumbar support and combat-related survival equipment remain relatively low-cost/high-yield topics worthy of further investigation for exploiting efficient means to improve health, safety, and operational performance. C1 [Kelley, Amanda M.; Grigley, Deahndra; Campbell, John] US Army Aeromed Res Lab, Aircrew Hlth & Performance Div, Ft Rucker, AL USA. [MacDonnell, Jason; Gaydos, Steven J.] US Army Sch Aviat Med, Ft Rucker, AL USA. RP Kelley, AM (reprint author), 4642 S 30th St, Arlington, VA 22206 USA. EM akelley1981@gmail.com NR 27 TC 0 Z9 0 U1 2 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 2375-6314 EI 2375-6322 J9 AEROSP MED HUM PERF JI Aerosp. Med.Hum. Perform. PD FEB PY 2017 VL 88 IS 2 BP 96 EP 103 DI 10.3357/AMHP.4740.2017 PG 8 WC Biophysics; Public, Environmental & Occupational Health; Medicine, Research & Experimental SC Biophysics; Public, Environmental & Occupational Health; Research & Experimental Medicine GA EI1TZ UT WOS:000392262300004 PM 28095953 ER PT J AU Mitrophanov, AY Szlam, F Sniecinski, RM Levy, JH Reifman, J AF Mitrophanov, Alexander Y. Szlam, Fania Sniecinski, Roman M. Levy, Jerrold H. Reifman, Jaques TI If the Goal Is Balance, Why Not Fresh Frozen Plasma? Response SO ANESTHESIA AND ANALGESIA LA English DT Letter ID RISK C1 [Mitrophanov, Alexander Y.; Reifman, Jaques] US Army Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Szlam, Fania; Sniecinski, Roman M.; Levy, Jerrold H.] Emory Univ, Sch Med, Dept Anesthesiol, Atlanta, GA 30322 USA. [Levy, Jerrold H.] Emory Univ, Sch Med, Dept Surg, Atlanta, GA 30322 USA. RP Mitrophanov, AY (reprint author), US Army Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. FU US Army Network Science Initiative, US Army Medical Research and Materiel Command, Ft. Detrick, MD FX This work was supported by the US Army Network Science Initiative, US Army Medical Research and Materiel Command, Ft. Detrick, MD. NR 5 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 2017 VL 124 IS 2 BP 699 EP 700 DI 10.1213/ANE.0000000000001763 PG 2 WC Anesthesiology SC Anesthesiology GA EI3CB UT WOS:000392366200048 PM 28098695 ER PT J AU Mitrophanov, AY Szlam, F Sniecinski, RM Levy, JH Reifman, J AF Mitrophanov, Alexander Y. Szlam, Fania Sniecinski, Roman M. Levy, Jerrold H. Reifman, Jaques TI Clinical and Practical Aspects of Restoring Thrombin Generation in Acute Coagulopathic Bleeding Response SO ANESTHESIA AND ANALGESIA LA English DT Letter C1 [Mitrophanov, Alexander Y.; Reifman, Jaques] US Army Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Szlam, Fania; Sniecinski, Roman M.] Emory Univ, Sch Med, Dept Anesthesiol, Atlanta, GA 30322 USA. [Levy, Jerrold H.] Duke Univ, Sch Med, Dept Anesthesiol, Durham, NC USA. [Levy, Jerrold H.] Duke Univ, Sch Med, Dept Surg, Durham, NC USA. RP Mitrophanov, AY (reprint author), US Army Med Res & Mat Command, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. FU US Army Network Science Initiative, US Army Medical Research and Materiel Command, Ft. Detrick, MD FX This research was supported by the US Army Network Science Initiative, US Army Medical Research and Materiel Command, Ft. Detrick, MD. NR 5 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 2017 VL 124 IS 2 BP 702 EP 702 DI 10.1213/ANE.0000000000001761 PG 1 WC Anesthesiology SC Anesthesiology GA EI3CB UT WOS:000392366200052 PM 28098699 ER PT J AU McWilliams, B Yu, J Kellogg, F Kilczewski, S AF McWilliams, Brandon Yu, Jian Kellogg, Frank Kilczewski, Steven TI Enhanced Sintering Kinetics in Aluminum Alloy Powder Consolidated Using DC Electric Fields SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID MECHANICAL-PROPERTIES; TEMPERATURE DISTRIBUTION; THERMAL RUNAWAY; PLASMA; GROWTH; MICROSTRUCTURE; DENSIFICATION; CONDUCTIVITY; DEFORMATION; SIMULATION AB Direct current (DC) electric currents were applied during sintering of aluminum alloy (AA5083) green powder compacts and it was found that the kinetics of sintering were greatly enhanced compared to samples processed without a field. In situ sintering kinetics during pressure-less sintering employing electric field strengths and amperages ranging from 0 to 56 V/cm and 0 to 3 A were quantified using digital image correlation. It was found that the application of a DC field during sintering results in a discontinuous change in volume at a critical temperature along with a transition in electrical properties of the compact from insulating to conductive. This effect is similar to the phenomena observed in the flash sintering process currently being actively researched for ceramic powder processing. The temperature at which the flash event occurs was found to be field strength dependent and doubling the field strength was found to decrease the flash temperature by 25 pct. Joule heating of the specimen was measured using thermal imaging and it was found to not contribute enough additional thermal energy to account for the substantially increased sintering rates observed in specimens processed using electric fields. C1 [McWilliams, Brandon; Yu, Jian] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Kellogg, Frank] Bowhead Sci & Technol, Belcamp, MD 21017 USA. [Kilczewski, Steven] TKC Global, Herndon, VA 20171 USA. RP McWilliams, B (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM brandon.a.mcwilliams.civ@mail.mil NR 53 TC 0 Z9 0 U1 4 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 EI 1543-1940 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD FEB PY 2017 VL 48A IS 2 BP 919 EP 929 DI 10.1007/s11661-016-3861-4 PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA EI2CL UT WOS:000392294000034 ER PT J AU Blakely, JN Milosavljevic, MS Corron, NJ AF Blakely, J. N. Milosavljevic, M. S. Corron, N. J. TI Timing variation in an analytically solvable chaotic system SO PHYSICA D-NONLINEAR PHENOMENA LA English DT Article DE Chaos; Analytic solution; Electronic circuit; Filter; Return map AB We present analytic solutions for a chaotic dynamical system that do not have the regular timing characteristic of recently reported solvable chaotic systems. The dynamical system can be viewed as a first order filter with binary feedback. The feedback state may be switched only at instants defined by an external clock signal. Generalizing from a period one clock, we show analytic solutions for period two and higher period clocks. We show that even when the clock 'ticks' randomly the chaotic system has an analytic solution. These solutions can be visualized in a stroboscopic map whose complexity increases with the complexity of the clock. We provide both analytic results as well as experimental data from an electronic circuit implementation of the system. Our findings bridge the gap between the irregular timing of well known chaotic systems such as Lorenz and Rossler and the well regulated oscillations of recently reported solvable chaotic systems. Published by Elsevier B.V. C1 [Blakely, J. N.; Milosavljevic, M. S.; Corron, N. J.] US Army Aviat & Missile Res, Charles M Bowden Lab, Dev & Engn Ctr, RDMR WDS R, Redstone Arsenal, AL 35898 USA. RP Blakely, JN (reprint author), US Army Aviat & Missile Res, Charles M Bowden Lab, Dev & Engn Ctr, RDMR WDS R, Redstone Arsenal, AL 35898 USA. EM jonathan.n.blakely.civ@mail.mil; marko.s.milosavljevic.civ@mail.mil; ned.j.corron.civ@mail.mil OI Corron, Ned/0000-0002-3232-5024 NR 25 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-2789 EI 1872-8022 J9 PHYSICA D JI Physica D PD FEB 1 PY 2017 VL 340 BP 40 EP 45 DI 10.1016/j.physd.2016.09.006 PG 6 WC Mathematics, Applied; Physics, Multidisciplinary; Physics, Mathematical SC Mathematics; Physics GA EI2YQ UT WOS:000392356500005 ER PT J AU Carlsson, AH Rose, LF Fletcher, JL Wu, JC Leung, KP Chan, RK AF Carlsson, Anders H. Rose, Lloyd F. Fletcher, John L. Wu, Jesse C. Leung, Kai P. Chan, Rodney K. TI Antecedent thermal injury worsens split-thickness skin graft quality: A clinically relevant porcine model of full-thickness burn, excision and grafting SO BURNS LA English DT Article DE Burn; Scar; Contraction ID ENDOTHELIAL GROWTH-FACTOR; SCAR FORMATION; INCREASES SURVIVAL; GRANULATION-TISSUE; TIME-COURSE; CONTRACTION; ANGIOGENESIS; EXPRESSION; FLAPS; KNOCKOUT AB Current standard of care for full-thickness burn is excision followed by autologous split-thickness skin graft placement. Skin grafts are also frequently used to cover surgical wounds not amenable to linear closure. While all grafts have potential to contract, clinical observation suggests that antecedent thermal injury worsens contraction and impairs functional and aesthetic outcomes. This study evaluates the impact of antecedent full-thickness burn on split-thickness skin graft scar outcomes and the potential mediating factors. Full-thickness contact burns (100 degrees C, 30s) were created on the backs of anesthetized female Yorkshire Pigs. After seven days, burn eschar was tangentially excised and covered with 12/1000th inch (300 mu m) split-thickness skin graft. For comparison, unburned wounds were created by sharp excision to fat before graft application. From 7 to 120days post-grafting, planimetric measurements, digital imaging and biopsies for histology, immunohistochemistry and gene expression were obtained. At 120days post-grafting, the Observer Scar Assessment Scale, colorimetry, contour analysis and optical graft height assessments were performed. Twenty-nine porcine wounds were analyzed. All measured metrics of clinical skin quality were significantly worse (p<0.05) in burn injured wounds. Histological analysis supported objective clinical findings with marked scar-like collagen proliferation within the dermis, increased vascular density, and prolonged and increased cellular infiltration. Observed differences in contracture also correlated with earlier and more prominent myofibroblast differentiation as demonstrated by alpha-SMA staining. Antecedent thermal injury worsens split-thickness skin graft quality, likely by multiple mechanisms including burn-related inflammation, microscopically inadequate excision, and dysregulation of tissue remodeling. A valid, reliable, clinically relevant model of full-thickness burn, excision and skin replacement therapy has been demonstrated. Future research to enhance quality of skin replacement therapies should be directed toward modulation of inflammation and assessments for complete excision. (C) 2016 Elsevier Ltd and ISBI. All rights reserved. C1 [Carlsson, Anders H.; Rose, Lloyd F.; Fletcher, John L.; Wu, Jesse C.; Leung, Kai P.; Chan, Rodney K.] US Army, Dent & Craniofacial Trauma Res & Tissue Regenerat, Inst Surg Res, 3650 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. [Fletcher, John L.; Chan, Rodney K.] US Army, Clin Div, Inst Surg Res, 3650 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. [Fletcher, John L.; Chan, Rodney K.] US Army, Burn Ctr, Inst Surg Res, 3650 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. RP Carlsson, AH (reprint author), US Army, Dent & Craniofacial Trauma Res & Tissue Regenerat, Inst Surg Res, 3650 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA. EM anders.h.carlsson.ctr@mail.mil OI Carlsson, Anders/0000-0002-4846-108X FU Department of Defense (DoD) FX This study was funded by the Department of Defense (DoD) and was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Medical Research and Materiel Command by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. NR 56 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD FEB PY 2017 VL 43 IS 1 BP 223 EP 231 DI 10.1016/j.burns.2016.08.006 PG 9 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA EI4PO UT WOS:000392476000032 PM 27600980 ER PT J AU Ayers, J Weerasooriya, T Ghoshal, A Pecora, C Gunnarsson, A Sanborn, B Turney, P AF Ayers, James Weerasooriya, Tusit Ghoshal, Anindya Pecora, Collin Gunnarsson, Allan Sanborn, Brett Turney, Peter TI Feasibility of component state awareness of high strain rate events using fiber Bragg grating sensors SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Material state awareness; Impact monitoring; High strain events; Fiber optic sensors AB Strategically located Fiber Bragg Grating (FBG) Sensors have been proposed as an in situ method to increase the signal to noise ratio (SNR) for metallic and composite components. This paper presents a systematic study that investigates the viability of FBG Sensors under high strain rate loading by initially measuring 1D strains in a compression Hopkinson bar experiment, followed by 2D full-field strain-tensor in impact and blast experiments on plates. Specifically, high strain rates from commercialized FBG Sensors are compared to traditional resistive and semi-conductor based strain gages under various levels of 1D high strain rate loading. In the projectile-plate impact experiments, full-field back-surface strain measured using FBG Sensor arrays are compared with that measured from 3D surface Digital Image Correlation (3D-sDIC) strain measuring technique. Finally, strains in welded steel plates subjected to high explosive discharge are monitored with mounted FBG Sensors on the back surface. From this study, potential improvements in the SNR of FBG Sensors are recommended, and the survivability of these sensors under more complex, dynamic loading is evaluated. Published by Elsevier Ltd. C1 [Ayers, James; Weerasooriya, Tusit; Ghoshal, Anindya; Pecora, Collin; Gunnarsson, Allan] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Sanborn, Brett] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Turney, Peter] Aberdeen Test Ctr, Aberdeen Proving Ground, MD USA. RP Ghoshal, A (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM anindya.ghoshal.civ@mail.mil NR 23 TC 0 Z9 0 U1 4 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD FEB PY 2017 VL 100 BP 166 EP 174 DI 10.1016/j.ijimpeng.2016.10.012 PG 9 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA EH6QB UT WOS:000391897900016 ER PT J AU Muscara, MJ Simper, NB Gandia, E AF Muscara, Matthew J. Simper, Novae B. Gandia, Edwin TI Thyroid-Like Follicular Carcinoma of the Kidney: An Emerging Renal Neoplasm With Curiously Misplaced Histologic Features; a Case Report SO INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY LA English DT Article DE thyroid-like follicular carcinoma; renal cell carcinoma; genitourinary ID OF-THE-LITERATURE; EXPRESSION AB Thyroid-like follicular carcinoma of the kidney (TLFCK) is a rare but emerging renal neoplasm that morphologically mimics follicular carcinoma of the thyroid but lacks immunohistochemical expression of thyroid markers such as TTF-1 and thyroglobulin. Here, a case of an incidentally discovered TLFCK in a 27-year-old man is reported. Histologic evaluation demonstrated an encapsulated proliferation of variably sized thyroid follicle-like epithelial-lined spaces filled with colloid-like eosinophilic secretions. Immunohistochemical analysis confirmed lack of expression of the thyroid markers TTF-1 and thyroglobulin with expression of PAX8 and CD10, confirming a neoplasm of renal origin, which correlated to the clinical and radiographic absence of thyroid pathology. In this report, this case is described with an emphasis on the differential diagnosis. C1 [Muscara, Matthew J.; Simper, Novae B.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Gandia, Edwin] Womack Army Med Ctr, Ft Bragg, NC USA. RP Muscara, MJ (reprint author), Madigan Army Med Ctr, Dept Pathol, 9040 Jackson Ave, Tacoma, WA 98431 USA. EM matthewmuscara@gmail.com NR 12 TC 0 Z9 0 U1 1 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1066-8969 EI 1940-2465 J9 INT J SURG PATHOL JI Int. J. Surg. Pathol. PD FEB PY 2017 VL 25 IS 1 BP 73 EP 77 DI 10.1177/1066896916662153 PG 5 WC Pathology; Surgery SC Pathology; Surgery GA EH4ZY UT WOS:000391783600015 PM 27474044 ER PT J AU Janak, JC Orman, JA Soderdahl, DW Hudak, SJ AF Janak, Judson C. Orman, Jean A. Soderdahl, Douglas W. Hudak, Steven J. TI Epidemiology of Genitourinary Injuries among Male US Service Members Deployed to Iraq and Afghanistan: Early Findings from the Trauma Outcomes and Urogenital Health (TOUGH) Project SO JOURNAL OF UROLOGY LA English DT Article DE urogenital system; wounds and injuries; blast injuries; penis; organ transplantation ID SEXUAL DYSFUNCTION; COMBAT; AMPUTATION; MANAGEMENT; OPERATIONS; AMPUTEES; IMPACT AB Purpose: In this study we report the number, nature and severity of genitourinary injuries among male U.S. service members deployed to Operations Iraqi Freedom and Enduring Freedom. Materials and Methods: This retrospective cross-sectional study of the Department of Defense Trauma Registry used ICD-9-CM codes to identify service members with genitourinary injuries, and used Abbreviated Injury Scale codes to determine injury severity, genitourinary organs injured and comorbid injuries. Results: From October 2001 to August 2013, 1,367 male U.S. service members sustained 1 or more genitourinary injuries. The majority of injuries involved the external genitalia (1,000, 73.2%), including the scrotum (760, 55.6%), testes (451, 33.0%), penis (423, 31%) and/or urethra (125, 9.1%). Overall more than a third of service members with genitourinary injury sustained at least 1 severe genitourinary injury (502, 36.7%). Loss of 1 or both testes was documented in 146 men, including 129 (9.4%) unilateral orchiectomies and 17 (1.2%) bilateral orchiectomies. Common comorbid injuries included traumatic brain injury (549, 40.2%), pelvic fracture (341, 25.0%), colorectal injury (297, 21.7%) and lower extremity amputations (387, 28.7%). Conclusions: An unprecedented number of U.S. service members sustained genitourinary injury while deployed to Operation Iraqi Freedom/Operation Enduring Freedom. Further study is needed to describe the long-term impact of genitourinary injury and determine the potential need for novel treatments to improve sexual, urinary and/or reproductive function among service members with severe genital injury. C1 [Janak, Judson C.; Orman, Jean A.] JBSA, US Army Inst Surg Res, Ft Sam Houston, TX USA. [Soderdahl, Douglas W.; Hudak, Steven J.] JBSA, San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. RP Hudak, SJ (reprint author), JBSA, San Antonio Mil Med Ctr, Dept Surg, Urol Clin, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Steven.J.Hudak2.mil@mail.mil NR 29 TC 1 Z9 1 U1 4 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD FEB PY 2017 VL 197 IS 2 BP 414 EP 419 DI 10.1016/j.juro.2016.08.005 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA EH8YT UT WOS:000392059300059 PM 27506692 ER PT J AU Martin, RF AF Martin, Ronald F. TI Emergency Pediatric Surgery Foreword SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Editorial Material C1 [Martin, Ronald F.] US Army, Reserve York Hosp, 16 Hosp Dr,Suite A, York, ME 03909 USA. RP Martin, RF (reprint author), US Army, Reserve York Hosp, 16 Hosp Dr,Suite A, York, ME 03909 USA. EM rmartin@yorkhospital.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 EI 1558-3171 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD FEB PY 2017 VL 97 IS 1 BP XIII EP XV DI 10.1016/j.suc.2016.11.002 PG 3 WC Surgery SC Surgery GA EH4YK UT WOS:000391779600001 PM 28325199 ER PT J AU Zhang, JF Blum, RS Kaplan, LM Lu, XX AF Zhang, Jiangfan Blum, Rick S. Kaplan, Lance M. Lu, Xuanxuan TI Functional Forms of Optimum Spoofing Attacks for Vector Parameter Estimation in Quantized Sensor Networks SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Spoofing attack; distributed vector parameter estimation; Cramer-Rao Bound; the expectation-maximization algorithm; sensor network ID DISTRIBUTED ESTIMATION; EM ALGORITHM; PERFORMANCE; LOCATION; INFERENCE AB Estimation of an unknown deterministic vector from quantized sensor data is considered in the presence of spoofing attacks, which alter the data presented to several sensors. Contrary to the previous work, a generalized attack model is employed which manipulates the data using transformations with arbitrary functional forms determined by some attack parameters whose values are unknown to the attacked system. For the first time, necessary and sufficient conditions are provided under which the transformations provide a guaranteed attack performance in terms of Cramer-Rao Bound (CRB) regardless of the processing the estimation system employs, thus defining a highly desirable attack. Interestingly, these conditions imply that, for any such attack when the attacked sensors can be perfectly identified by the estimation system, either the Fisher information matrix (FIM) for jointly estimating the desired and attack parameters is singular or that the attacked system is unable to improve the CRB for the desired vector parameter through this joint estimation even though the joint FIM is nonsingular. It is shown that it is always possible to construct such a highly desirable attack by properly employing a sufficiently large dimension attack vector parameter relative to the number of quantization levels employed, which was not observed previously. To illustrate the theory in a concrete way, we also provide some numerical results which corroborate that under the highly desirable attack, attacked data are not useful in reducing the CRB. C1 [Zhang, Jiangfan; Blum, Rick S.; Lu, Xuanxuan] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. [Zhang, Jiangfan] Columbia Univ, Dept Elect Engn, New York, NY 10027 USA. [Kaplan, Lance M.] US Army Res Lab, Networked Sensing & Fus Branch, Adelphi, MD 20783 USA. RP Zhang, JF (reprint author), Columbia Univ, Dept Elect Engn, New York, NY 10027 USA. EM jiangfan.zhang@columbia.edu; rblum@eecs.lehigh.edu; lance.m.kaplan@us.army.mil; xul311@lehigh.edu FU U.S. Army Research Laboratory; U.S. Army Research Office; [W911NF-14-1-0245]; [W911NF-14-1-0261] FX This work was supported by the U.S. Army Research Laboratory and the U.S. Army Research Office and was accomplished under Agreement W911NF-14-1-0245 and W911NF-14-1-0261. NR 34 TC 0 Z9 0 U1 3 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X EI 1941-0476 J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD FEB 1 PY 2017 VL 65 IS 3 BP 705 EP 720 DI 10.1109/TSP.2016.2626258 PG 16 WC Engineering, Electrical & Electronic SC Engineering GA EG8GJ UT WOS:000391293800013 ER PT J AU Taylor, DE AF Taylor, DeCarlos E. TI Molecular dynamics simulation of the Hugoniot states of boron suboxide SO MATERIALS LETTERS LA English DT Article DE Boron suboxide; Compression; Hugoniot; Molecular dynamics ID CARBIDE; AMORPHIZATION; SHEAR AB It has been previously demonstrated in a number of studies that the strength of boron carbide can be significantly reduced via introduction of a site vacancy. The site vacancies result in a discontinuous shock response at high pressure that is driven by bond formation between atoms which neighbor the vacancies. In this work, molecular dynamics simulations of boron suboxide (B6O) have been conducted to determine whether an analogous bond formation occurs at high pressure producing discontinuities in the B6O Hugoniot. Hugoniot data for ideal boron suboxide, a defect structure of boron suboxide, and a carbon doped structure are provided and the structural response of the oxygen atoms within the B6O crystal with increasing shock pressure is presented. (C) 2016 Published by Elsevier B.V. C1 [Taylor, DeCarlos E.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Taylor, DE (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM decarlos.e.taylor.civ@mail.mil NR 14 TC 0 Z9 0 U1 8 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-577X EI 1873-4979 J9 MATER LETT JI Mater. Lett. PD FEB 1 PY 2017 VL 188 BP 331 EP 333 DI 10.1016/j.matlet.2016.11.118 PG 3 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA EG0RS UT WOS:000390740500087 ER PT J AU Mayer, C AF Mayer, Chris TI Lesson plan: an agenda for change in American higher education SO JOURNAL OF HIGHER EDUCATION POLICY AND MANAGEMENT LA English DT Book Review C1 [Mayer, Chris] US Mil Acad, West Point, NY 10996 USA. RP Mayer, C (reprint author), US Mil Acad, West Point, NY 10996 USA. EM Christopher.mayer@usma.edu NR 1 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1360-080X EI 1469-9508 J9 J HIGH EDUC POLICY M JI J. High. Educ. Policy Manag. PD FEB PY 2017 VL 39 IS 1 BP 116 EP 118 DI 10.1080/1360080X.2017.1254378 PG 3 WC Education & Educational Research SC Education & Educational Research GA EG2LR UT WOS:000390875600010 ER PT J AU Cole, WR Arrieux, JP Dennison, EM Ivins, BJ AF Cole, Wesley R. Arrieux, Jacques P. Dennison, Elizabeth M. Ivins, Brian J. TI The impact of administration order in studies of computerized neurocognitive assessment tools (NCATs) SO JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY LA English DT Article DE Computerized neurocognitive tests; Computerized cognitive testing; Computerized neurocognitive assessment tools; Neuropsychological assessment; Order of test administration; Practice effects ID TEST-RETEST RELIABILITY; NEUROPSYCHOLOGICAL ASSESSMENT; TEST-PERFORMANCE; ALTERNATE FORMS; TEST LENGTH; WAIS-III; WMS-III; CONCUSSION; BATTERY; TESTS AB Computerized neurocognitive assessment tools (NCATs) have become a common way to assess postconcussion symptoms. As there is increasing research directly comparing multiple NCATs to each other, it is important to consider the impact that order of test administration may have on the integrity of the results. This study investigates the impact of administration order in a study of four different NCATs; Automated Neuropsychological Assessment Metrics (ANAM4), CNS Vital Signs (CNS-VS), CogState, and Immediate Post-Concussion Assessment and Cognitive Test (ImPACT). A total of 272 healthy active duty Service Members were enrolled into this study. All participants were randomly assigned to take two of the four NCATs with order of administration counterbalanced. Analyses attempted to investigate the effect of administration order alone (e.g., Time 1 versus Time 2), the effect of administration order combined with the impact of the specific NCAT received at Time 1, and only the impact of the Time 1 NCAT on Time 2 score variability. Specifically, independent samples ttests were used to compare Time 1 and Time 2 scores within each NCAT. Additional ttests compared Time 1 to Time 2 scores with Time 2 scores grouped by the NCAT received at Time 1. One-way analysis of variance (ANOVA) was used to compare only an NCAT's Time 2 scores grouped by the NCAT received at Time 1. Cohen's d effect sizes were calculated for all comparisons. The results from this study revealed statistically significant order effects for CogState and CNS-VS, though with effect sizes generally indicating minimum practical value, and marginal or absent order effects for ANAM4 and ImPACT with no clinically meaningful implications. Despite finding minimal order effects, clinicians should be mindful of the impact of administering multiple NCATs in a single session. Future studies should continue to be designed to minimize the potential effect of test administration order. C1 [Cole, Wesley R.; Arrieux, Jacques P.; Dennison, Elizabeth M.] Womack Army Med Ctr, Intrepid Spirit, Ft Bragg, NC 28310 USA. [Cole, Wesley R.; Arrieux, Jacques P.; Dennison, Elizabeth M.] DVBIC, Ft Bragg, NC USA. [Ivins, Brian J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Ivins, Brian J.] DVBIC, Div Res, Silver Spring, MD USA. RP Cole, WR (reprint author), Womack Army Med Ctr, Intrepid Spirit, Ft Bragg, NC 28310 USA. EM wesley.r.cole.ctr@mail.mil NR 32 TC 0 Z9 0 U1 58 U2 58 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1380-3395 EI 1744-411X J9 J CLIN EXP NEUROPSYC JI J. Clin. Exp. Neuropsychol. PD FEB PY 2017 VL 39 IS 1 BP 35 EP 45 DI 10.1080/13803395.2016.1198470 PG 11 WC Psychology, Clinical; Clinical Neurology; Psychology SC Psychology; Neurosciences & Neurology GA EE3OH UT WOS:000389499700004 PM 27690742 ER PT J AU Gonzalez, R Jayakumar, P Iagnemma, K AF Gonzalez, Ramon Jayakumar, Paramsothy Iagnemma, Karl TI Generation of stochastic mobility maps for large-scale route planning of ground vehicles: A case study SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Stochastic conditional simulation; Geographical Information System (GIS); Next-Generation NATO Reference Mobility Model (NG-NRMM); Digital Elevation Model (DEM); Soil moisture ID UNCERTAINTY; PREDICTION; EXPLORATION; SIMULATION; TERRAIN; ERROR; SLOPE; MODEL; SOIL AB This paper describes a simple and efficient methodology to generate a mobility map accounting for two sources of uncertainty, namely measurement errors (RMSE of a Digital Elevation Model) and interpolation error (kriging method). The proposed methodology means a general-purpose solution since it works with standard and publicly-available Digital Elevation Models (DEMs). The different regions in the map are classified according to the geometry of the surface (i.e. slope) and the soil type. A real USGS DEM demonstrates the suitability of the proposed methodology: (1) interpolation of a 26 x 40-km(2) DEM to a finer resolution (30-m to 20-m); (2) analysis of the number of random realizations to account for the variability of the data; (3) efficient computation time (4-million-point DEM requires less than 30 min to complete the whole process); (4) route planning using the stochastic mobility map (constraints in slope and soil properties). (C) 2016 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 [Gonzalez, Ramon; Iagnemma, Karl] MIT, 77 Massachusetts Ave Bldg 35, Cambridge, MA 02139 USA. [Jayakumar, Paramsothy] US Army, RDECOM TARDEC, 6501 E 11 Mile Rd MS 157 Bldg 215, Warren, MI 48397 USA. RP Gonzalez, R (reprint author), MIT, 77 Massachusetts Ave Bldg 35, Cambridge, MA 02139 USA. EM ramong@mit.edu; paramsothy.jaya-kumar.civ@mail.mil; kdi@mit.edu FU US Army TARDEC [W911NF-13-1-0063] FX The research described in this publication was carried out at the Massachusetts Institute of Technology, under the Army Research Project Grant W911NF-13-1-0063 funded by US Army TARDEC. UNCLASSIFIED: Distribution Statement A. Approved for public release; distribution is unlimited. #27681 NR 45 TC 0 Z9 0 U1 8 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 EI 1879-1204 J9 J TERRAMECHANICS JI J. Terramech. PD FEB PY 2017 VL 69 BP 1 EP 11 DI 10.1016/j.jterra.2016.10.001 PG 11 WC Engineering, Environmental SC Engineering GA EE7GU UT WOS:000389784700001 ER PT J AU Colmer, T Daniewicz, SR Newman, JC Moser, R AF Colmer, Tinsley Daniewicz, S. R. Newman, J. C., Jr. Moser, Robert TI Measuring fatigue crack growth and closure in Polyether Ether Ketone (PEEK) SO INTERNATIONAL JOURNAL OF FATIGUE LA English DT Article DE PEEK; Fatigue crack growth ID FRACTURE-BEHAVIOR AB Throughout industry, polymers are being used to replace parts that were previously fabricated from metals. Thus, the fatigue resistance of polymers needs to be well understood. Polyether Ether Ketone (PEEK) is often chosen for its good mechanical properties and high glass transition temperature. In this paper, the experiments and methods to study fatigue crack growth and subsequent crack closure are presented. Compact specimens made of PEEK were used to experimentally monitor fatigue crack growth at R = 0.1 and R = 0.7. Some unique aspects of the experiments include the use of compression pre cracking and a back-face strain gauge to measure crack length. While measuring crack closure was the primary focus of the experiments, crack growth rate versus stress intensity factor range results were also generated. Using remote methods of measuring crack closure show that PEEK experiences a small level of crack closure, though the effects are minimal. However, indirect methods of measuring crack closure show that the phenomenon is more prevalent in the material than what was measured. Further research for continuing the study of fatigue crack closure in PEEK are discussed. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Colmer, Tinsley; Daniewicz, S. R.; Newman, J. C., Jr.] Mississippi State Univ, Mississippi State, MS 39762 USA. [Moser, Robert] US Army, Engineer Res Ctr, Vicksburg, MS USA. RP Daniewicz, SR (reprint author), Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA. EM srdaniewicz@ua.edu FU Engineering Research & Development Center [W912HZ-15-2-0004]; U.S. Army Engineer Research and Development Center (ERDC) FX Effort sponsored by the Engineering Research & Development Center under Cooperative Agreement number W912HZ-15-2-0004. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the Engineering Research & Development Center or the U.S. Government.; The authors would like to thank the Department of Aerospace Engineering for the use of the Fatigue and Fracture Laboratory while performing experiments. The authors also extend gratitude to the U.S. Army Engineer Research and Development Center (ERDC) for funding. NR 10 TC 0 Z9 0 U1 12 U2 12 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-1123 EI 1879-3452 J9 INT J FATIGUE JI Int. J. Fatigue PD FEB PY 2017 VL 95 BP 243 EP 251 DI 10.1016/j.ijfatigue.2016.10.025 PG 9 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA ED8ZN UT WOS:000389159700022 ER PT J AU Knapik, JJ Jean, RT Austin, KG Steelman, RA Farina, EK Lieberman, HR AF Knapik, Joseph J. Jean, Rosenie T. Austin, Krista G. Steelman, Ryan A. Farina, Emily K. Lieberman, Harris R. TI Demographic factors associated with dietary supplement prescriptions filled by United States Military Service Members 2005-2013 SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE LA English DT Article DE Multivitamins; Vitamins; Minerals; Iron; Zinc; Replacement preparations; Sodium/potassium compounds; Antacids; Absorbents ID NUTRITION EXAMINATION SURVEY; TREATMENT FACILITIES 2007; VITAMIN-D DEFICIENCY; ROUTINE IRON SUPPLEMENTATION; ACUTE PHOSPHATE NEPHROPATHY; CLINICAL-TRIAL DATA; CARDIOVASCULAR-DISEASE; NATIONAL-HEALTH; RENAL-FAILURE; PRIMARY PREVENTION AB Background: Dietary supplements (DSs) can be purchased over-the-counter but may also be prescribed by medical personnel for specific therapeutic reasons. Few studies have examined this latter source of DSs despite the fact that 79% of physicians and 82% of nurses have recommended DSs to their patients. This investigation examined demographic factors associated with temporal trends in oral DS prescriptions filled by all United States (US) service members (SMs) from 2005 to 2013 (n = 1,427,080 +/- 22,139, mean +/- standard deviation per year). Methods: The Food and Drug Administration National Drug Code database and the formularies of the US Defense Health Agency's Pharmacoeconomic Center were queried to identify DSs available to SMs. The number of these DS prescriptions filled by all SMs from 2005 through 2013 was then obtained from the US Department of Defense Pharmacy Data Transaction System. Data were grouped by American Hospital Formulary System (AHFS) pharmacologic-therapeutic classifications and examined over time. Denominators (number of SMs each year) were obtained from the Defense Health Agency. Results: Major findings included 1) generally greater prevalence of prescriptions filled by women and older SMs for most AHFS categories; 2) a temporal decline in total prescriptions filled by Marine Corps personnel accounted for by a decline in the prevalence of zinc preparations filled by younger male Marines; 3) a temporal decline in the prevalence of iron preparations filled by women; 4) a temporal increase in the prevalence of prescriptions for replacement preparations filled by women accounted for largely by more prescriptions for calcium compounds; and 5) a temporal decline in the prevalence of prescriptions filled for cathartics/laxatives in older SMs accounted for largely by a decline in prescriptions for sodium/potassium compounds. Conclusions: These temporal trends may be associated with the greater health care utilization of women and older SMs as well as the perceptions of prescribers and/or patients on appropriate roles of these substances in medicine and public health. C1 [Knapik, Joseph J.; Austin, Krista G.; Farina, Emily K.; Lieberman, Harris R.] US Army, Environm Med Res Inst, Natick, MA 01760 USA. [Knapik, Joseph J.] US Army, Publ Hlth Ctr, Aberdeen Proving Ground, MD 21005 USA. [Knapik, Joseph J.; Austin, Krista G.; Farina, Emily K.] Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA. [Jean, Rosenie T.] Off US Army Surg Gen Pharmacovigilance Ctr, Falls Church, VA USA. [Steelman, Ryan A.] Def Hlth Agcy, Falls Church, VA USA. [Knapik, Joseph J.] USARIEM, 10 Gen Greene Ave, Natick, MA 01760 USA. RP Knapik, JJ (reprint author), US Army, Environm Med Res Inst, Natick, MA 01760 USA.; Knapik, JJ (reprint author), US Army, Publ Hlth Ctr, Aberdeen Proving Ground, MD 21005 USA.; Knapik, JJ (reprint author), Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA.; Knapik, JJ (reprint author), USARIEM, 10 Gen Greene Ave, Natick, MA 01760 USA. EM joseph.j.knapik.ctr@mail.mil FU Center Alliance for Nutrition and Dietary Supplement Research FX This research was supported in part by an appointment to the Knowledge Preservation Program at the US Army Research Institute of Environmental Medicine (USARIEM) and the Army Public Health Center (APHC) administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARIEM and APHC. Funding was also provided by the Center Alliance for Nutrition and Dietary Supplement Research. NR 76 TC 0 Z9 0 U1 1 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6882 J9 BMC COMPLEM ALTERN M JI BMC Complement. Altern. Med. PD JAN 31 PY 2017 VL 17 AR 84 DI 10.1186/s12906-017-1590-x PG 14 WC Integrative & Complementary Medicine SC Integrative & Complementary Medicine GA EJ1VR UT WOS:000392998800005 PM 28148262 ER PT J AU Martinez, N Kumar, N Mishra, RS Doherty, KJ AF Martinez, N. Kumar, N. Mishra, R. S. Doherty, K. J. TI Effect of tool dimensions and parameters on the microstructure of friction stir welded aluminum 7449 alloy of various thicknesses SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Aluminum 7449; Friction stir welding; Microstructure; Heat gradient; Natural aging; GP zones ID EVOLUTION; MODEL AB Friction stir welding is a solid state joining technique in which no melting is involved. This technique is very attractive for high strength aluminum alloys, since these are difficult to weld by conventional means. Al-Zn-MgCu alloys are strengthened mainly by metastable,eta' precipitates. Microstructural evaluation was done on an aluminum 7449 alloy of various thicknesses after friction stir welding. Microhardness, TEM, and DSC were done to characterize the welds. The effects of natural aging and artificial aging were studied to understand re precipitation of the strengthening precipitates in the weld. A noticeable heat gradient was observed. Furthermore, tool dimensions and the parameters chosen influence the dissolution and re-precipitation of the weld, with negligible dependence on the plate thickness. C1 [Martinez, N.; Kumar, N.; Mishra, R. S.] Univ North Texas, Dept Mat Sci & Engn, Ctr Frict Stir Proc, Denton, TX 76203 USA. [Doherty, K. J.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Mishra, RS (reprint author), Univ North Texas, Dept Mat Sci & Engn, Ctr Frict Stir Proc, Denton, TX 76203 USA. FU University of North Texas [W911NF-13-2-0018]; Army Research Laboratory [W911NF-13-2-0018] FX The work was performed under a cooperative agreement between the Army Research Laboratory and the University of North Texas (W911NF-13-2-0018). The authors are thankful to the Center for Advanced Research and Technology (CART) for providing access to the microscopy facilities at the University of North Texas. NR 23 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JAN 27 PY 2017 VL 684 BP 470 EP 479 DI 10.1016/j.msea.2016.12.077 PG 10 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA EK5AC UT WOS:000393938300055 ER PT J AU Driscoll, DM Tang, WJ Burrows, SP Panayotov, DA Neurock, M McEntee, M Morris, JR AF Driscoll, Darren M. Tang, Wenjie Burrows, Steven P. Panayotov, Dimitar A. Neurock, Matthew McEntee, Monica Morris, John R. TI Binding Sites, Geometry, and Energetics of Propene at Nanoparticulate Au/TiO2 SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID INITIO MOLECULAR-DYNAMICS; OXYGEN-COVERED AU(111); AUGMENTED-WAVE METHOD; GOLD NANOPARTICLES; DIRECT EPOXIDATION; AU NANOPARTICLES; CO OXIDATION; PHASE EPOXIDATION; HYDRO-EPOXIDATION; PERIMETER SITES AB Surface adsorption and activation of propene, to catalytically produce propene oxide, is the first step in the industrially important gas-phase epoxidation reaction. Motivated by the significant practical importance of this reaction, site-specific adsorption of propene on nanoparticulate titania-supported Au (Au/TiO2) has been systematically characterized through Fourier transform infrared (FTIR) spectroscopy and density functional theoretical (DFT) calculations. The infrared spectra, recorded during propene uptake at low surface temperatures, and DFT calculations identified two distinct propene surface binding motifs. Propene was found to bind to the surface through a pi-interaction at TiO2 sites remote from the Au particles and through a (pi sigma)-interaction at a single atomic Au site, distinguishable through the stretching frequency of the propene double bond. Temperature-programmed desorption and calculated binding enthalpies for the minimum-energy configurations revealed the propene-Au interaction to have a stronger binding energy relative to the propene-TiO2 interaction. Upon coordination to Au, the double bond of propene was found to weaken and elongate, a possible first step in the activation and epoxidation to form propene oxide. C1 [Driscoll, Darren M.; Burrows, Steven P.; Morris, John R.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. [Tang, Wenjie; Neurock, Matthew] Univ Minnesota, Dept Chem Engn & Mat Sci, Minneapolis, MN 55455 USA. [Panayotov, Dimitar A.] Bulgarian Acad Sci, Inst Gen & Inorgan Chem, Sofia 1113, Bulgaria. [McEntee, Monica] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Morris, JR (reprint author), Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. EM jrmorris@vt.edu OI Driscoll, Darren/0000-0001-8859-8016 FU U. S. Army Research Laboratory; U. S. Army Research Office [W911NF-14-1-0159] FX This material is based upon work supported by the U. S. Army Research Laboratory and the U. S. Army Research Office under grant number W911NF-14-1-0159. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of the ARO, or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright annotation thereon. We also gratefully thank the XSEDE computing resources from Texas Advanced Computing Center and San Diego Supercomputer Center for all of the DFT calculations. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Edgewood Chemical Biological Center administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAECBC. NR 55 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JAN 26 PY 2017 VL 121 IS 3 BP 1683 EP 1689 DI 10.1021/acs.jpcc.6b10997 PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA EJ1ZI UT WOS:000393008900036 ER PT J AU Batyrev, IG AF Batyrev, I. G. TI Modeling of Extended N-H Solids at High Pressures SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID NITROGEN; CHEMISTRY AB The formation of nitrogen hydrogen networked compounds is a promising approach for obtaining high energy density materials. Multiple experimental reports indicate that the synthesis pressure and temperature of high-energy nitrogen networked compounds significantly decrease when adding hydrogen to nitrogen. One and two-dimensional structures of nitrogen hydrogen mixtures are reported to form during synthesis and have also been observed with simulations; however, the structures are not thoroughly established or well understood. Here, we present results of calculations of nitrogen hydrogen mixtures at pressures up to 50 GPa and predict their structural transformations upon applying and releasing pressure using density functional theory and evolutionary algorithms. Improvements in the computational procedure resulted in efficient on-the-fly elimination of slowly converging structures during the geometry optimization process. This enabled the continuation of long evolution simulations of the nitrogen-hydrogen structures with N/H ratios of 3:1, 4:1, and 9:1 at high pressures (10-50 GPa). New stable crystalline structures with high symmetry and covalent bonds are predicted that have (i) infinite chains and (ii) two-dimensional sheets of nitrogen-hydrogens. The structure with N/H ratio of 4:1 is found to be metallic at 50 GPa. Some crystalline phases stabilized by high pressure may exist as metastable structures with high symmetry and high mass density after lowering the pressure from 50 GPa down to 10 GPa. Vibration modes of calculated Raman and IR spectra are in agreement with published experimental data. C1 [Batyrev, I. G.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Batyrev, IG (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM iskander.g.batyrev.civ@mail.mil NR 23 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD JAN 26 PY 2017 VL 121 IS 3 BP 638 EP 647 DI 10.1021/acs.jpca.6b08255 PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA EJ1ZN UT WOS:000393009400010 PM 28005354 ER PT J AU Regules, JA Beigel, JH Paolino, KM Voell, J Castellano, AR Hu, Z Munoz, P Moon, JE Ruck, RC Bennett, JW Twomey, PS Gutierrez, RL Remich, SA Hack, HR Wisniewski, ML Josleyn, MD Kwilas, SA Van Deusen, N Mbaya, OT Zhou, Y Stanley, DA Jing, W Smith, KS Shi, M Ledgerwood, JE Graham, BS Sullivan, NJ Jagodzinski, LL Peel, SA Alimonti, JB Hooper, JW Silvera, PM Martin, BK Monath, TP Ramsey, WJ Link, CJ Lane, HC Michael, NL Davey, RT Thomas, SJ AF Regules, J. A. Beigel, J. H. Paolino, K. M. Voell, J. Castellano, A. R. Hu, Z. Munoz, P. Moon, J. E. Ruck, R. C. Bennett, J. W. Twomey, P. S. Gutierrez, R. L. Remich, S. A. Hack, H. R. Wisniewski, M. L. Josleyn, M. D. Kwilas, S. A. Van Deusen, N. Mbaya, O. T. Zhou, Y. Stanley, D. A. Jing, W. Smith, K. S. Shi, M. Ledgerwood, J. E. Graham, B. S. Sullivan, N. J. Jagodzinski, L. L. Peel, S. A. Alimonti, J. B. Hooper, J. W. Silvera, P. M. Martin, B. K. Monath, T. P. Ramsey, W. J. Link, C. J. Lane, H. C. Michael, N. L. Davey, R. T., Jr. Thomas, S. J. CA rVSV G-ZEBOV-GP Study Grp TI A Recombinant Vesicular Stomatitis Virus Ebola Vaccine SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID NONHUMAN-PRIMATES; MARBURG VIRUSES; VECTORS; PROTECTION; NEUROVIRULENCE; GLYCOPROTEINS; IMMUNIZATION; CHALLENGE AB BACKGROUND The worst Ebola virus disease (EVD) outbreak in history has resulted in more than 28,000 cases and 11,000 deaths. We present the final results of two phase 1 trials of an attenuated, replication-competent, recombinant vesicular stomatitis virus (rVSV)-based vaccine candidate designed to prevent EVD. METHODS We conducted two phase 1, placebo-controlled, double-blind, dose-escalation trials of an rVSV-based vaccine candidate expressing the glycoprotein of a Zaire strain of Ebola virus (ZEBOV). A total of 39 adults at each site (78 participants in all) were consecutively enrolled into groups of 13. At each site, volunteers received one of three doses of the rVSV-ZEBOV vaccine (3 million plaque-forming units [PFU], 20 million PFU, or 100 million PFU) or placebo. Volunteers at one of the sites received a second dose at day 28. Safety and immunogenicity were assessed. RESULTS The most common adverse events were injection-site pain, fatigue, myalgia, and headache. Transient rVSV viremia was noted in all the vaccine recipients after dose 1. The rates of adverse events and viremia were lower after the second dose than after the first dose. By day 28, all the vaccine recipients had seroconversion as assessed by an enzyme-linked immunosorbent assay (ELISA) against the glycoprotein of the ZEBOV-Kikwit strain. At day 28, geometric mean titers of antibodies against ZEBOV glycoprotein were higher in the groups that received 20 million PFU or 100 million PFU than in the group that received 3 million PFU, as assessed by ELISA and by pseudovirion neutralization assay. A second dose at 28 days after dose 1 significantly increased antibody titers at day 56, but the effect was diminished at 6 months. CONCLUSIONS This Ebola vaccine candidate elicited anti-Ebola antibody responses. After vaccination, rVSV viremia occurred frequently but was transient. These results support further evaluation of the vaccine dose of 20 million PFU for preexposure prophylaxis and suggest that a second dose may boost antibody responses. (Funded by the National Institutes of Health and others; rVSV Delta G-ZEBOV-GP ClinicalTrials.gov numbers, NCT02269423 and NCT02280408.) C1 [Regules, J. A.; Paolino, K. M.; Castellano, A. R.; Moon, J. E.; Ruck, R. C.; Bennett, J. W.; Twomey, P. S.; Remich, S. A.; Hack, H. R.; Shi, M.; Jagodzinski, L. L.; Peel, S. A.; Michael, N. L.; Thomas, S. J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Gutierrez, R. L.] Naval Med Res Ctr, Silver Spring, MD USA. [Beigel, J. H.; Jing, W.] Frederick Natl Lab Canc Res, Leidos Biomed Res, Frederick, MD USA. [Wisniewski, M. L.; Josleyn, M. D.; Kwilas, S. A.; Van Deusen, N.; Smith, K. S.; Hooper, J. W.; Silvera, P. M.] US Army Med Res Inst Infect Dis, Frederick, MD USA. [Voell, J.; Hu, Z.; Munoz, P.; Lane, H. C.; Davey, R. T., Jr.] NIAID, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Mbaya, O. T.; Zhou, Y.; Stanley, D. A.; Ledgerwood, J. E.; Graham, B. S.; Sullivan, N. J.] NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Alimonti, J. B.] Publ Hlth Agcy Canada, Ottawa, ON, Canada. [Martin, B. K.; Monath, T. P.; Ramsey, W. J.; Link, C. J.] BioProtect Syst NewLink Genet, Ames, IA USA. RP Regules, JA (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM jason.a.regules.mil@mail.mil FU Intramural Research Programs of the National Institute of Allergy and Infectious Diseases, NIH; National Cancer Institute, NIH [HHSN261200800001E]; Defense Threat Reduction Agency; Joint Vaccine Acquisition Program FX Supported by the Intramural Research Programs of the National Institute of Allergy and Infectious Diseases, NIH; the National Cancer Institute, NIH (contract no. HHSN261200800001E); the Defense Threat Reduction Agency; and the Joint Vaccine Acquisition Program. NR 27 TC 3 Z9 3 U1 7 U2 7 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JAN 26 PY 2017 VL 376 IS 4 BP 330 EP 341 DI 10.1056/NEJMoa1414216 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA EJ3KR UT WOS:000393111600008 PM 25830322 ER PT J AU Rokni, MR Widener, CA Champagne, VK Crawford, GA Nutt, SR AF Rokni, M. R. Widener, C. A. Champagne, V. K. Crawford, G. A. Nutt, S. R. TI The effects of heat treatment on 7075 Al cold spray deposits SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE Aluminum alloys; Cold spraying; Aging; Annealing; Mechanical properties; Electron microscopy ID GAS-ATOMIZED POWDER; MG-CU ALLOYS; MECHANICAL-PROPERTIES; ALUMINUM-ALLOY; MICROSTRUCTURAL EVOLUTION; ANNEALING BEHAVIOR; STRENGTH; RECRYSTALLIZATION; DUCTILITY; COATINGS AB High-pressure cold spray was used to deposit 7075 aluminum powder onto 7075-T6 substrates. We investigated the effects of post deposition heat treatments on the microstructure and mechanical properties of the deposits. For this purpose, both low-temperature and high-temperature treatments were carried out on specimens excised from the deposits. Microstructures of the as-deposited and heat treated samples were characterized via different microscopy techniques and mechanical properties were evaluated by microtensile and hardness tests. The results were then correlated with the observed microstructures in different conditions. The strength and ductility of the cold sprayed 7075 deposits increased after both low- and high-temperature treatments, which resulted in precipitation of strengthening phases and increased inter-particle bonding. Because of a change in bonding mechanism, heat treatment at high temperature yielded markedly greater ductility than all other conditions. Diffusion and microstructural sintering at the particle-particle interfaces were proposed to cause the change in bonding mechanism from mechanical interlocking to metallurgical bonding and lead to the ductile characteristics of these samples. The understanding gained from this research should lead to optimization of and pre- and post-processing treatments for cold spray deposits. (C) 2016 Elsevier B.V. All rights reserved. C1 [Rokni, M. R.; Nutt, S. R.] Univ Southern Calif, Dept Chem Engn & Mat Sci, MC Gill Composites Ctr, Los Angeles, CA 90007 USA. [Widener, C. A.; Crawford, G. A.] South Dakota Sch Mines & Technol, Adv Mat Proc Ctr, Dept Mat & Met Engn, Rapid City, SD USA. [Champagne, V. K.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA. RP Rokni, MR (reprint author), Univ Southern Calif, Dept Chem Engn & Mat Sci, MC Gill Composites Ctr, Los Angeles, CA 90007 USA. EM rokni@usc.edu FU Army Research Lab (ARL) [W911NF-11-2-0014] FX The authors are grateful for the financial support of the Army Research Lab (ARL) under contract no. W911NF-11-2-0014. would like to sincerely thank the Department of Materials Science & Engineering at Boise State University, especially Dr. Darryl P. Butt and Brian Jaques for their help and support for microtensile testing. Mike Carter et al. at AMP tech lab are also gratefully acknowledged for coordinating the deposition of the material for this analysis. NR 39 TC 0 Z9 0 U1 5 U2 5 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD JAN 25 PY 2017 VL 310 BP 278 EP 285 DI 10.1016/j.surfcoat.2016.10.064 PG 8 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA EJ6RV UT WOS:000393347400037 ER PT J AU Emdadi, L Tran, DT Wu, YQ Oh, SC Zhu, GH Lee, IC Liu, DX AF Emdadi, Laleh Tran, Dat T. Wu, Yiqing Oh, Su Cheun Zhu, Guanghui Lee, Ivan C. Liu, Dongxia TI BEA nanosponge/ultra-thin lamellar MFI prepared in one-step: Integration of 3D and 2D zeolites into a composite for efficient alkylation reactions SO APPLIED CATALYSIS A-GENERAL LA English DT Article DE Lamellar-bulk zeolite composites; Meso-/microporosity; Hierarchical structure; Dual template; Alkylation reaction ID ACID-CATALYZED REACTIONS; CORE-SHELL COMPOSITE; MAS NMR; METHANE DEHYDROAROMATIZATION; MICRO/MESOPOROUS COMPOSITES; STRUCTURAL-CHARACTERIZATION; HIERARCHICAL ZEOLITES; MO/HZSM-5 CATALYSTS; STRUCTURE-DIRECTION; EPITAXIAL-GROWTH AB The synthesis of hierarchical meso-/microporous zeolite materials with spatially controlled morphology, meso-imicroporosity, and acidity is an expanding area of research interest for a wide range of applications. Here, we report a one-step dual template synthesis method for integration of 3-dimensional (3D) BEA nanosponge and ultra-thin 2D lamellar MFI into a new type of hierarchical meso-/microporous zeolite composite structures. Specifically, the 2D layered MFI nanosheets were laid over the surface of or interdigitated into the 3D BEA particles in the bulk BEA nanosponge-lamellar MFI (BBLM) zeolite structure, which generated a unique morphology of interconnected micropores and mesopores underneath the 'skinning' shell (similar to 3-10 nm) of MFI nanosheets. The BBLM zeolites have higher mesoporosity than either bare BEA or lamellar MFI zeolites. The micropore size decreases with increasing lamellar MFI component in the composite. The fraction of external acid sites of BBLM zeolite composite, represented by the percentage of active sites accessible to bulky organic base molecules, decreases with increasing MFI component. Additionally, the types of acid sites are diversified in the BBLM composites compared to either bare BEA or lamellar MFI zeolites. The catalysis tests using conversion of benzyl alcohol in mesitylene showed that BBLM zeolites had significant higher activity and durability than single zeolites or their physical mixture. The BBLM zeolite composite provides a good model catalyst with integrated 2D-3D structures and meso-/microporosity for studying a series of important catalytic reactions in hierarchical zeolites. The one-step dual template synthesis method described herein is versatile and facile, which may prove to be a general platform for hierarchical zeolite composite design at the unit-cell scales of zeolites and with potentially broader applicability to other porous materials. (C) 2016 Elsevier B.V. All rights reserved. C1 [Emdadi, Laleh; Wu, Yiqing; Oh, Su Cheun; Liu, Dongxia] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Tran, Dat T.; Lee, Ivan C.] US Army, Res Lab, RDRL SED E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Zhu, Guanghui] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA. RP Liu, DX (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. EM liud@umd.edu FU Army Research Laboratory [5284201]; National Science Foundation [NSF-CBET 1264599, 1351384]; Maryland NanoCenter and its AIMLab; University of Maryland Energy Research Center (UMERC) FX The authors gratefully acknowledge financial support from the Army Research Laboratory (5284201) and National Science Foundation (NSF-CBET 1264599 and 1351384). We acknowledge the support of Maryland NanoCenter and its AIMLab. Laleh Emdadi thanks for the Hulka Energy Research Fellowship from University of Maryland Energy Research Center (UMERC) to support her research. NR 72 TC 0 Z9 0 U1 11 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-860X EI 1873-3875 J9 APPL CATAL A-GEN JI Appl. Catal. A-Gen. PD JAN 25 PY 2017 VL 530 BP 56 EP 65 DI 10.1016/j.apcata.2016.11.011 PG 10 WC Chemistry, Physical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA EI8WK UT WOS:000392788700007 ER PT J AU Asenath-Smith, E Noble, JM Hovden, R Uhl, AM DiCorato, A Kim, YY Kulak, AN Meldrum, FC Kourkoutis, LF Estroff, LA AF Asenath-Smith, Emily Noble, Jade M. Hovden, Robert Uhl, Amanda M. DiCorato, Allessandra Kim, Yi-Yeoun Kulak, Alexander N. Meldrum, Fiona C. Kourkoutis, Lena F. Estroff, Lara A. TI Physical Confinement Promoting Formation of Cu2O-Au Heterostructures with Au Nanoparticles Entrapped within Crystalline Cu2O Nanorods SO CHEMISTRY OF MATERIALS LA English DT Article ID CALCITE SINGLE-CRYSTALS; SOLAR-CELLS; NANOSCALE CONFINEMENT; SCREW DISLOCATIONS; LATEX-PARTICLES; CUPROUS-OXIDE; NANOWIRES; NANOSTRUCTURES; GROWTH; METAL AB Building on the application of cuprite (Cu2O) in solar energy technologies and reports of increased optical absorption caused by metal-to-semiconductor energy transfer, a confinement-based strategy was developed to fabricate high aspect ratio, crystalline Cu2O nanorods containing entrapped gold nanoparticles (Au nps). Cu2O was crystallized within the confines of track-etch membrane pores, where this physical, assembly based method eliminates the necessity of specific chemical interactions to achieve a well-defined metal semiconductor interface. With high-resolution scanning/transmission electron microscopy (S/TEM) and tomography, we demonstrate the encasement of the majority of Au nps by crystalline Cu2O and show crystalline Cu2O Au interfaces that are free of extended amorphous regions. Such nanocrystal heterostructures are good candidates for studying the transport physics of metal/semiconductor hybrids for optoelectronic applications. C1 [Asenath-Smith, Emily; Uhl, Amanda M.; DiCorato, Allessandra; Estroff, Lara A.] Cornell Univ, Dept Mat Sci & Engn, Ithaca, NY 14853 USA. [Noble, Jade M.] Cornell Univ, Robert Frederick Smith Sch Chem & Biomol Engn, Ithaca, NY 14853 USA. [Hovden, Robert; Kourkoutis, Lena F.] Cornell Univ, Sch Appl & Engn Phys, Ithaca, NY 14853 USA. [Kim, Yi-Yeoun; Kulak, Alexander N.; Meldrum, Fiona C.] Univ Leeds, Sch Chem, Woodhouse Lane, Leeds LS2 9JT, W Yorkshire, England. [Kourkoutis, Lena F.; Estroff, Lara A.] Cornell Univ, Kavli Inst Cornell Nanoscale Sci, Ithaca, NY 14853 USA. [Asenath-Smith, Emily] US Army, ERDC, CRREL, Hanover, NH 03755 USA. RP Asenath-Smith, E; Estroff, LA (reprint author), Cornell Univ, Dept Mat Sci & Engn, Ithaca, NY 14853 USA.; Estroff, LA (reprint author), Cornell Univ, Kavli Inst Cornell Nanoscale Sci, Ithaca, NY 14853 USA.; Asenath-Smith, E (reprint author), US Army, ERDC, CRREL, Hanover, NH 03755 USA. EM emily.asenath-smith@usace.army.mil; lae37@cornell.edu OI Kourkoutis, Lena/0000-0002-1303-1362 FU NSF [DMR 1210304]; NSF Graduate Research Fellowship (GRF) [DGE-0707428]; Integrative Graduate Education and Research Traineeship (IGERT) [DGE-0903653]; Cornell Center for Materials Research (CCMR); NSF MRSEC program [DMR 1120296]; Engineering and Physical Sciences Research Council (EPSRC) Materials World Network grant [EP/J018589/1]; EPSRC grant [EP/K006304/1] FX We acknowledge support from the NSF (DMR 1210304), and E.A.-S. acknowledges the NSF Graduate Research Fellowship (GRF, DGE-0707428) and Integrative Graduate Education and Research Traineeship (IGERT, DGE-0903653) Programs. This work was also supported in part by the Cornell Center for Materials Research (CCMR) and made use of the CCMR Shared Facilities, both funded by NSF MRSEC program (DMR 1120296). We also acknowledge support from an Engineering and Physical Sciences Research Council (EPSRC) Materials World Network grant (EP/J018589/1, F.C.M. and Y.-Y.K.) and EPSRC grant EP/K006304/1 (F.C.M. and A.N.K.). Specific acknowledgment is made for the assistance of Malcolm G. Thomas and John L. Grazul during the use of the electron microscopy facilities. NR 76 TC 0 Z9 0 U1 7 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 EI 1520-5002 J9 CHEM MATER JI Chem. Mat. PD JAN 24 PY 2017 VL 29 IS 2 BP 555 EP 563 DI 10.1021/acs.chemmater.6b03653 PG 9 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA EJ0IL UT WOS:000392891700012 ER PT J AU Bolton, DL Song, KM Tomaras, GD Rao, S Roederer, M AF Bolton, Diane L. Song, Kaimei Tomaras, Georgia D. Rao, Srinivas Roederer, Mario TI Unique cellular and humoral immunogenicity profiles generated by aerosol, intranasal, or parenteral vaccination in rhesus macaques SO VACCINE LA English DT Article DE Aerosol; Nasal; Vaccine delivery route; Immunogenicity; Rhesus macaque ID ORIGINAL ANTIGENIC SIN; IMMUNE-RESPONSES; NEUTRALIZING ANTIBODIES; MEASLES VACCINATION; IMMUNIZATION; SECRETIONS; GENE; PROTECTION; CHALLENGE; VACCINES AB Respiratory mucosa immunization is capable of eliciting both local and distal mucosal immune responses; it is a potentially powerful yet largely unused modality for vaccination against respiratory diseases. Targeting the lower versus upper airways by aerosol delivery alters the immunogenicity profile of a vaccine, although the full extent of this impact is not well characterized. We set out to define the cellular and humoral response profiles elicited by immunization via intranasal, small aerosol droplets, and large aerosol droplets. We compared responses following adenovirus-vectored vaccination by these routes in macaques, either for the generation of primary immune responses or for the boosting of previously primed systemic responses. Aerosol delivery (4 or 10 mu m diameter droplets, addressing lower or upper airways, respectively) generated the highest magnitude lung CD4 and CD8 T-cell responses, reaching 10-30% vaccine-specific levels in bronchoalveolar lavage cells. In contrast, intranasal delivery was less immunogenic with >10-fold lower peak lung T-cell responses. Systemic (blood) T-cell responses were only observed following 4 pm aerosol (and parenteral) immunization, while all delivery routes elicited similar humoral responses. These data demonstrate distinct immune response profiles with each respiratory tract vaccination modality and suggest that small droplet aerosol offers several immunological advantages over other respiratory routes. Published by Elsevier Ltd. C1 [Bolton, Diane L.; Song, Kaimei; Rao, Srinivas; Roederer, Mario] NIAID, ImmunoTechnol Sect, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Tomaras, Georgia D.] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA. [Bolton, Diane L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Bolton, Diane L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20818 USA. [Rao, Srinivas] SanofiPasteur, 38 Sidney St 370, Cambridge, MA 02139 USA. RP Roederer, M (reprint author), NIAID, ImmunoTechnol Sect, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA. EM roederer@nih.gov FU Intramural Research Program of the Vaccine Research Center, NIAID, NIH; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067] FX This work was supported by the Intramural Research Program of the Vaccine Research Center, NIAID, NIH and by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). The views expressed are those of the authors and should not be construed to represent the positions of the US Army or the Department of Defense. NR 36 TC 0 Z9 0 U1 4 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 23 PY 2017 VL 35 IS 4 BP 639 EP 646 DI 10.1016/j.vaccine.2016.12.008 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA EK1XQ UT WOS:000393721500020 PM 28041780 ER PT J AU Matheny, RW Abdalla, MN Geddis, AV Leandry, LA Lynch, CM AF Matheny, Ronald W., Jr. Abdalla, Mary N. Geddis, Alyssa V. Leandry, Luis A. Lynch, Christine M. TI Skeletal muscle PI3K p110 beta regulates expression of AMP-activated protein kinase SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article DE AMP-activated protein kinase (AMPK); Phosphoinositide 3-kinase (PI3K); Myoblast; Skeletal muscle ID PHOSPHOINOSITIDE 3-KINASES; EXERCISE INTENSITY; AKT ACTIVATION; PHOSPHORYLATION; P110-ALPHA; MYOBLASTS; SER(485/491); DOWNSTREAM AB Skeletal muscle metabolic homeostasis is maintained through numerous biochemical and physiological processes. Two principal molecular regulators of skeletal muscle metabolism include AMP-activated protein kinase (AMPK) and phosphatidylinositol 3-kinase (PI3K); however, PI3K exists as multiple isoforms, and specific metabolic actions of each isoform have not yet been fully elucidated in skeletal muscle. Given this lack of knowledge, we performed a series of experiments to define the extent to which PI3K p110 beta mediated expression and (or) activation of AMPK in skeletal muscle. To determine the effect of p110 beta inhibition on AMPK expression and phosphorylation in cultured cells, C2C12 myoblasts were treated with a pharmacological inhibitor of p110 beta (TGX-221), siRNA against p110 beta, or overexpression of kinase-dead p110 beta. Expression and phosphorylation of AMPK were unaffected in myoblasts treated with TGX-221 or expressing kinase-dead p110 beta. However, expressions of total and phosphorylated AMPK at T172 were reduced in myoblasts treated with p110 beta siRNA. When normalized to expression of total AMPK, phosphorylation of AMPK S485/491 was elevated in p110 beta-deficient myoblasts. Similar results were observed in tibialis anterior muscle from mice with conditional deletion of p110 beta (p110 beta-mKO mice). Analysis of AMPK transcript expression revealed decreased expression of Prkaa2 in p110 beta-deficient myoblasts and in p110 beta-mKO muscle. Loss of p110 beta had no effect on oligomycin-stimulated phosphorylation of AMPK or phosphorylated Acetyl-CoA carboxylase (ACC), although oligomycin-induced AMPK and ACC phosphorylation were increased in p110 beta-deficient myoblasts compared to oligomycin-stimulated control myoblasts when normalized to levels of total AMPK or ACC. Overall, these results suggest that p110 beta positively regulates expression of AMPK in cultured myoblasts and in skeletal muscle in vivo; moreover, despite the reduced abundance of AMPK in p110 beta-deficient myoblasts, loss of p110 beta does not appear to impair AMPK activation following stimulus. These findings thus reveal a novel role for p110 beta in mediating skeletal muscle metabolic signaling. Published by Elsevier Inc. C1 [Matheny, Ronald W., Jr.; Abdalla, Mary N.; Geddis, Alyssa V.; Leandry, Luis A.; Lynch, Christine M.] US Army Res Inst Environm Med, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. RP Matheny, RW (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA. EM ronald.w.matheny.civ@mail.mil NR 24 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X EI 1090-2104 J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD JAN 22 PY 2017 VL 482 IS 4 BP 1420 EP 1426 DI 10.1016/j.bbrc.2016.12.051 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA EK1XB UT WOS:000393720000138 PM 27965101 ER PT J AU Mait, JN AF Mait, J. N. TI US Army Research Laboratory focus issue: introduction SO APPLIED OPTICS LA English DT Editorial Material AB The U.S. Army Research Laboratory (ARL) is the premier laboratory for land forces in the United States. A young organization that in 2017 celebrates 25 years of discovery, innovation, and transition of science and technology, ARL has already contributed significantly to several disciplines in optical sciences. (C) 2016 Optical Society of America C1 [Mait, J. N.] US Army Res Lab, RDRL D, 2800 Powder Mill Rd, Adelphi, MD 20833 USA. RP Mait, JN (reprint author), US Army Res Lab, RDRL D, 2800 Powder Mill Rd, Adelphi, MD 20833 USA. EM joseph.n.mait2.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP ARL1 EP ARL1 DI 10.1364/AO.56.00ARL1 PG 1 WC Optics SC Optics GA EJ6SA UT WOS:000393347900001 PM 28157881 ER PT J AU Beresnev, LA Motes, RA Townes, KJ Marple, P Gurton, K Valenzuela, AR Williamson, C Liu, JJ Washer, C AF Beresnev, Leonid A. Motes, R. Andrew Townes, Keith J. Marple, Patrick Gurton, Kristan Valenzuela, Anthony R. Williamson, Chatt Liu, Jony J. Washer, Chris TI Design of a noncooled fiber collimator for compact, high-efficiency fiber laser arrays SO APPLIED OPTICS LA English DT Article ID BEAM AB A high-power fiber laser collimator and array of collimators are described with optical architecture, allowing one to transmit almost 100% of the full power output from fiber facets. In the case of coherent beam combining, more than 70% of the full power can be focused into a diffraction limited spot determined by the diameter of the conformal aperture. The truncated-Gaussian beam tails are not trapped inside the array but are redirected through the output lenses and dispersed outside of the array along with the main collimated beam, thus eliminating the requirement for cooling the array. Detailed analysis is presented for the beam tail propagation geometry's dependence on array optical parameters, including the interior redirecting lenses. The parasitic scattering from imperfections of the interior lenses is estimated to be as small as a few watts when 1.5-2 kW is emitted by each fiber facet. (C) 2016 Optical Society of America C1 [Beresnev, Leonid A.; Townes, Keith J.; Gurton, Kristan; Valenzuela, Anthony R.; Williamson, Chatt; Liu, Jony J.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Motes, R. Andrew; Washer, Chris] Schafer Corp, 2309 Renard Pl SE,Suite 300, Albuquerque, NM 87106 USA. [Marple, Patrick] Univ Maryland Baltimore Cty, 1000 Hilltop Circle, Baltimore, MD 21250 USA. RP Beresnev, LA (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM leonid.a.beresnev.civ@mail.mil FU U.S. Army FX U.S. Army. NR 16 TC 0 Z9 0 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B169 EP B178 DI 10.1364/AO.56.00B169 PG 10 WC Optics SC Optics GA EJ6SA UT WOS:000393347900023 PM 28157879 ER PT J AU Blair, VL Fleischman, ZD Merkle, LD Ku, N Moorehead, CA AF Blair, Victoria L. Fleischman, Zackery D. Merkle, Larry D. Ku, Nicholas Moorehead, Carli A. TI Co-precipitation of rare-earth-doped Y2O3 and MgO nanocomposites for mid-infrared solid-state lasers SO APPLIED OPTICS LA English DT Article ID CERAMIC LASER; YTTRIA NANOPOWDERS; GEL COMBUSTION; MU-M; TRANSPARENT; DECOMPOSITION; EFFICIENCY; CO2 AB Mid-infrared, solid-state laser materials face three main challenges: (1) need to dissipate heat generated in lasing; (2) luminescence quenching by multiphonon relaxation; and (3) trade-off in high thermal conductivity and small maximum phonon energy. We are tackling these challenges by synthesizing a ceramic nanocomposite in which multiple phases will be incorporated into the same structure. The undoped majority species, MgO, will be the main carrier of high thermal conductivity, and the minority species, Er: Y2O3, will have low maximum phonon energy. There is also an inherent challenge in attempting to make a translucent part from a mixture of two different materials with two different indexes of refraction. A simple, co-precipitation technique has been developed in which both components are synthesized in situ to obtain intimate mixing. These powders compare well to commercially available ceramics, including their erbium spectroscopy, even when mixed as a composite, and can be air-fired to similar to 96% of theoretical density, yielding translucent parts. As the amount of Er: Y2O3 increases, the translucency decreases as the number of scattering sites start to coalesce into large patches. If the amount of Er: Y2O3 is sufficiently small and dispersed, the yttria grains will be pinned as individuals in a sea of MgO, leading to optimal translucency. C1 [Blair, Victoria L.; Fleischman, Zackery D.; Merkle, Larry D.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Ku, Nicholas] Oak Ridge Inst Sci Educ, 1299 Bethel Valley Rd, Oak Ridge, TN 37830 USA. [Moorehead, Carli A.] Drexel Univ, 3141 Chestnut St, Philadelphia, PA 19104 USA. RP Blair, VL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Victoria.L.Blair3.civ@mail.mil OI Moorehead, Carli/0000-0002-1592-4295 FU Oak Ridge Institute for Science and Education (ORISE) [1120-1120-99]; Science & Engineering Apprenticeship Program (SEAP) [W911SR-15-2-0001] FX Oak Ridge Institute for Science and Education (ORISE) (1120-1120-99); Science & Engineering Apprenticeship Program (SEAP) (W911SR-15-2-0001). NR 38 TC 0 Z9 0 U1 9 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B154 EP B158 DI 10.1364/AO.56.00B154 PG 5 WC Optics SC Optics GA EJ6SA UT WOS:000393347900021 PM 28157873 ER PT J AU Cahill, JP Zhou, WM Menyuk, CR AF Cahill, James P. Zhou, Weimin Menyuk, Curtis R. TI Additive phase noise of fiber-optic links used in photonic microwave-generation systems SO APPLIED OPTICS LA English DT Article ID SINGLE-MODE FIBERS; RAYLEIGH-SCATTERING; OPTICAL-FIBERS; LASER FREQUENCY; BACKSCATTERING; FLUCTUATIONS; OSCILLATORS AB In this work, we analyze the contributions of several mechanisms to the additive phase noise of the optical fiber in a microwave-photonic link. We discuss their fiber-length dependence and their impact on the phase noise of an optoelectronic oscillator. Furthermore, we present and verify for the first time a mechanism by which double-Rayleigh scattering directly generates microwave phase noise. (C) 2016 Optical Society of America C1 [Cahill, James P.; Zhou, Weimin] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Menyuk, Curtis R.] Univ Maryland Baltimore Cty, Dept Comp Sci & Elect Engn, 1000 Hilltop Cir, Baltimore, MD 21250 USA. RP Cahill, JP (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM james.p.cahill15.civ@mail.mil NR 22 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B18 EP B25 DI 10.1364/AO.56.000B18 PG 8 WC Optics SC Optics GA EJ6SA UT WOS:000393347900005 PM 28157861 ER PT J AU Choi, KK Mait, JN Pellegrino, JM Wood, GL AF Choi, K. K. Mait, J. N. Pellegrino, J. M. Wood, G. L. TI Optics research at the US Army Research Laboratory SO APPLIED OPTICS LA English DT Review ID PUPIL-FUNCTION DESIGN; QUANTUM-WELL; ELEMENTS; EFFICIENCY; ENHANCEMENT; ABSORPTION; POLYMERS; GROWTH; FILTER; IMAGE AB The U.S. Army Research Laboratory (ARL) is the Army's premier laboratory for land forces. The Army relies on ARL for scientific discoveries, technological advances, and analyses that enable capabilities a future Army will need to persevere over adversaries. Although a relatively young organization that will celebrate 25 years of the discovery, innovation, and transition of science and technology in October 2017, ARL has already had significant impact in a wide range of scientific and technological disciplines. In this paper, we highlight some of its past and recent achievements in optics and photonics. (C) 2016 Optical Society of America C1 [Choi, K. K.; Mait, J. N.; Pellegrino, J. M.; Wood, G. L.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20833 USA. RP Choi, KK (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20833 USA. EM kwong.k.choi.civ@mail.mil NR 60 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B103 EP B115 DI 10.1364/AO.56.00B103 PG 13 WC Optics SC Optics GA EJ6SA UT WOS:000393347900016 PM 28157872 ER PT J AU Choi, KK Allen, SC Sun, JG Wei, Y Olver, KA Fu, RX AF Choi, K. K. Allen, S. C. Sun, J. G. Wei, Y. Olver, K. A. Fu, R. X. TI Resonant structures for infrared detection SO APPLIED OPTICS LA English DT Article ID SUPERLATTICES; ABSORPTION AB We are developing resonator-quantum well infrared photodetectors (R-QWIPs) for long-wavelength applications. Detector pixels with 25 mu m pitch were hybridized to fan-out circuits for radiometric measurements. With a moderate doping of 0.5 x 10(18) cm(-3), we achieved a quantum efficiency (QE) of 37% and conversion efficiency (CE) of 15% in a 1.3 mu m thick active material and 35% QE and 21% CE in a 0.6 mu m thick active material. Both detectors are cutoff at 10.5 mu m with a 2 mu m bandwidth. The temperature at which photocurrent equals dark current is about 65 K under F/2 optics. The thicker detector shows a large QE polarity asymmetry due to nonlinear potential drop in the QWIP material layers. (C) 2016 Optical Society of America C1 [Choi, K. K.; Sun, J. G.; Olver, K. A.; Fu, R. X.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20833 USA. [Allen, S. C.; Wei, Y.] L3 Commun Cincinnati Elect, 7500 Innovat Way, Mason, OH 45040 USA. RP Choi, KK (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20833 USA. EM kwong.k.choi.civ@mail.mil NR 15 TC 1 Z9 1 U1 5 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B26 EP B36 DI 10.1364/AO.56.000B26 PG 11 WC Optics SC Optics GA EJ6SA UT WOS:000393347900006 PM 28157862 ER PT J AU Dang, NC Gottfried, JL De Lucia, FC AF Dang, N. C. Gottfried, J. L. De Lucia, F. C., Jr. TI Energetic material response to ultrafast indirect laser heating SO APPLIED OPTICS LA English DT Article ID TRANSIENT ABSORPTION-SPECTROSCOPY; WAVE INDUCED DECOMPOSITION; SHOCK-INDUCED CHEMISTRY; EXPLOSIVE DECOMPOSITION; NANOENERGETIC MATERIALS; DYNAMIC ELLIPSOMETRY; CHEMICAL-REACTIONS; MOLECULAR-SOLIDS; RDX; COMPRESSION AB The initial evolution of thermal energy transfer into a solid explosive is studied using an indirect femtosecond laser heating technique on a picosecond timescale in order to elucidate the role of temperature in the shockinduced initiation of explosives. The indirect laser heating method is presented; time-resolved visible transient absorption (TA) spectroscopy was used to monitor the energetic material response following heat transfer from the laser-heated gold (Au) layer to the sample. Reported here are visible TA data in the spectral region from 500 to 750 nm for indirect laser-heated thin films of cyclotrimethylene trinitramine (RDX), oxidized polyethylene (OPE), and RDX with 1%, 2.5%, 5%, or 10% OPE prior to decomposition. TA was observed for RDX and RDX with OPE; however, no TA was observed for pure OPE. Compared to pure RDX, the TA intensity of RDX with OPE decreases as the OPE content increases and the time required to observe the TA signal from RDX increases. Our results suggest that the thermal energy produced by a femtosecond laser pulse with an energy of 15 mJ cm(-2) is sufficient to induce changes in the electronic structure of RDX, resulting in promotion of the RDX molecules into an excited state. We also determined that the heat transfer rate in RDX depends on its homogeneity and degree of purity. C1 [Dang, N. C.; Gottfried, J. L.; De Lucia, F. C., Jr.] US Army Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. RP Dang, NC (reprint author), US Army Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM nhan.c.dang.civ@mail.mil FU Army Research Laboratory (ARL) FX Army Research Laboratory (ARL). NR 33 TC 0 Z9 0 U1 2 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B85 EP B91 DI 10.1364/AO.56.000B85 PG 7 WC Optics SC Optics GA EJ6SA UT WOS:000393347900013 PM 28157869 ER PT J AU Dean, SW De Lucia, FC Gottfried, JL AF Dean, Steven W. De Lucia, Frank C., Jr. Gottfried, Jennifer L. TI Indirect ignition of energetic materials with laser-driven flyer plates SO APPLIED OPTICS LA English DT Article ID INDUCED SHOCK-WAVES; MINI-FLYER; ACCELERATION; INITIATION; SYSTEM; THIN; BEAM AB The impact of laser-driven flyer plates on energetic materials CL-20, PETN, and TATB has been investigated. Flyer plates composed of 25 mu m thick Al were impacted into the energetic materials at velocities up to 1.3 km/s. The flyer plates were accelerated by means of an Nd: YAG laser pulse. The laser pulse generates rapidly expanding plasma between the flyer plate foil and the substrate to which it is adhered. As the plasma grows, a section of the metal foil is ejected at high speed, forming the flyer plate. The velocity of the flyer plate was determined using VISAR, time of flight, and high-speed video. The response of the energetic material to impact was determined by light emission recorded by an infrared-sensitive photodiode. Following post-impact analysis of the impacted energetic material, it was hypothesized that the light emitted by the material after impact is not due to the impact of the flyer itself but rather is caused by the decomposition of energetic material ejected ( via the shock of flyer plate impact) into a cloud of hot products generated during the launch of the flyer plate. This hypothesis was confirmed through schlieren imaging of a flyer plate launch, clearly showing the ejection of hot gases and particles from the region surrounding the flyer plate launch and the burning of the ejected energetic material particles. C1 [Dean, Steven W.; De Lucia, Frank C., Jr.; Gottfried, Jennifer L.] US Army Res Lab, RDRL WML B, Aberdeen, MD 21005 USA. RP Dean, SW (reprint author), US Army Res Lab, RDRL WML B, Aberdeen, MD 21005 USA. EM steven.w.dean14.civ@mail.mil FU Oak Ridge Association of Universities (ORAU) [W911NF-16-2-0075] FX Oak Ridge Association of Universities (ORAU) (W911NF-16-2-0075). NR 40 TC 0 Z9 0 U1 4 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B134 EP B141 DI 10.1364/AO.56.00B134 PG 8 WC Optics SC Optics GA EJ6SA UT WOS:000393347900019 PM 28157876 ER PT J AU Don, ML Fu, C Arce, GR AF Don, Michael L. Fu, Chen Arce, Gonzalo R. TI Compressive imaging via a rotating coded aperture SO APPLIED OPTICS LA English DT Article ID BLUE-NOISE; RECONSTRUCTION AB Compressive sensing has been used to increase the resolution of sensor arrays, allowing high-resolution images to be obtained from low-resolution or even single pixel sensors. This paper introduces a rotating coded aperture for compressive imaging that has advantages over other sensing strategies. The design of the code geometry is motivated by constraints imposed by the imager's rotation. The block-unblock code pattern is optimized by minimizing the mutual coherence of the sensing matrix. Simulation results are presented, using the final code design to successfully recover high-resolution images from a very small sensor array. (C) 2016 Optical Society of America C1 [Don, Michael L.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Fu, Chen; Arce, Gonzalo R.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. RP Don, ML (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM michael.l.don2.civ@mail.mil FU Army Research Laboratory (ARL) [W911NF-14-2-0108] FX Army Research Laboratory (ARL) (W911NF-14-2-0108). NR 37 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B142 EP B153 DI 10.1364/AO.56.00B142 PG 12 WC Optics SC Optics GA EJ6SA UT WOS:000393347900020 PM 28157877 ER PT J AU Farrell, ME Strobbia, P Pellegrino, PM Cullum, B AF Farrell, Mikella E. Strobbia, Pietro Pellegrino, Paul M. Cullum, Brian TI Surface regeneration and signal increase in surface-enhanced Raman scattering substrates SO APPLIED OPTICS LA English DT Review ID DEMAND INKJET TECHNOLOGY; LARGE AG NANOCRYSTALS; SINGLE-MOLECULE; SILVER NANOPARTICLES; GOLD NANOPARTICLES; HOT-SPOTS; METAL NANOPARTICLES; PLASMON RESONANCE; AU NANOPARTICLES; SERS BIOSENSOR AB Regenerated surface-enhanced Raman scattering (SERS) substrates allow users the ability to not only reuse sensing surfaces, but also tailor them to the sensing application needs (wavelength of the available laser, plasmon band matching). In this review, we discuss the development of SERS substrates for response to emerging threats and some of our collaborative efforts to improve on the use of commercially available substrate surfaces. Thus, we are able to extend the use of these substrates to broader Army needs (like emerging threat response). (C) 2017 Optical Society of America C1 [Farrell, Mikella E.; Pellegrino, Paul M.] US Army Res Lab ARL, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Strobbia, Pietro; Cullum, Brian] Univ Maryland Baltimore Cty, Dept Chem & Biochem, 1000 Hilltop Circle Rd, Baltimore, MD 21250 USA. RP Farrell, ME (reprint author), US Army Res Lab ARL, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Mikella.E.Farrell.civ@mail.mil OI Strobbia, Pietro/0000-0003-0884-6185 FU U.S. Army Research Laboratory FX Dr. Cullum would like to thank the U.S. Army Research Laboratory for support during his sabbatical leave, during which part of this work was performed, as well as Dr. Gougousi for assistance in the ALD deposition of the titanium dioxide for the multilayer studies. NR 244 TC 0 Z9 0 U1 7 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B198 EP B213 DI 10.1364/AO.56.00B198 PG 16 WC Optics SC Optics GA EJ6SA UT WOS:000393347900027 PM 28157898 ER PT J AU Ghosh, A Powers, MA Patel, VM AF Ghosh, Arthita Powers, Michael A. Patel, Vishal M. TI Computational LADAR imaging SO APPLIED OPTICS LA English DT Article ID ALGORITHM; SPARSITY; SENSOR AB Most LADAR (laser radar, LIDAR) imaging systems use pixel-basis sampling, where each azimuth and elevation resolution element is uniquely sampled and recorded. We demonstrate and examine alternative sampling and post-detection processing schemes where recorded measurements are made in alternative bases that are intended to reduce system power consumption and laser emissions. A prototype of such a sensor having the capability to generate arbitrary illumination beam patterns rather than spot, line scanning, or flash techniques is described along with computational imaging algorithms to reduce speckle and identify scene objects in a low-dimensional compressed basis rather than in the pixel basis. Such techniques yield considerable energy savings and prove valuable when used on platforms with severe limitations on sensor size, weight, and power, and in particular as part of autonomous systems where image output for human interpretation is unnecessary. (C) 2017 Optical Society of America C1 [Ghosh, Arthita] Univ Maryland, UMIACS, College Pk, MD 20742 USA. [Powers, Michael A.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Patel, Vishal M.] Rutgers State Univ, 94 Brett Rd, Piscataway, NJ 08854 USA. RP Powers, MA (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM michael.a.powers70.civ@mail.mil FU Army Research Laboratory (ARL) [W911NF-10-2-0016]; General Dynamics (GD) [40212299] FX Army Research Laboratory (ARL) (W911NF-10-2-0016); General Dynamics (GD) (40212299). NR 23 TC 0 Z9 0 U1 2 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B191 EP B197 DI 10.1364/AO.56.00B191 PG 7 WC Optics SC Optics GA EJ6SA UT WOS:000393347900026 PM 28157883 ER PT J AU Glick, Y Fromzel, V Zhang, J Ter-Gabrielyan, N Dubinskii, M AF Glick, Yaakov Fromzel, Viktor Zhang, Jun Ter-Gabrielyan, Nikolay Dubinskii, Mark TI High-efficiency, 154 W CW, diode-pumped Raman fiber laser with brightness enhancement SO APPLIED OPTICS LA English DT Article ID HIGH-POWER; MULTIMODE FIBER AB We demonstrate a high-power, high-efficiency Raman fiber laser pumped directly by laser diode modules at 978 nm. 154 W of CW power were obtained at a wavelength of 1023 nm with an optical to optical efficiency of 65%. A commercial graded-index (GRIN) core fiber acts as the Raman fiber in a power oscillator configuration, which includes spectral selection to prevent generation of the second Stokes. In addition, brightness enhancement of the pump beam by a factor of 8.4 is attained due to the Raman gain distribution profile in the GRIN fiber. To the best of our knowledge this is the highest power and highest efficiency Raman fiber laser demonstrated in any configuration allowing brightness enhancement (i.e., in either cladding-pumped configuration or with GRIN fibers, excluding step-index core pumped), regardless of pumping scheme (i.e., either diode pumped or fiber laser pumped). (C) 2016 Optical Society of America C1 [Glick, Yaakov; Fromzel, Viktor; Zhang, Jun; Ter-Gabrielyan, Nikolay; Dubinskii, Mark] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Glick, Yaakov] Soreq Nucl Res Ctr, Div Appl Phys, Laser Dept, IL-81800 Yavne, Israel. RP Glick, Y (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.; Glick, Y (reprint author), Soreq Nucl Res Ctr, Div Appl Phys, Laser Dept, IL-81800 Yavne, Israel. EM yaakovgl@soreq.gov.il NR 19 TC 1 Z9 1 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B97 EP B102 DI 10.1364/AO.56.000B97 PG 6 WC Optics SC Optics GA EJ6SA UT WOS:000393347900015 PM 28157871 ER PT J AU Gottfried, JL Bukowski, EJ AF Gottfried, Jennifer L. Bukowski, Eric J. TI Laser-shocked energetic materials with metal additives: evaluation of chemistry and detonation performance SO APPLIED OPTICS LA English DT Article ID BORON PARTICLES; ALUMINIZED EXPLOSIVES; COMBUSTION; IGNITION; RDX; SENSITIVITY; MAGNESIUM; SYSTEMS; PLASMA; BLAST AB A focused, nanosecond-pulsed laser has been used to ablate, atomize, ionize, and excite milligram quantities of metal-doped energetic materials that undergo exothermic reactions in the laser-induced plasma. The subsequent shock wave expansion in the air above the sample has been monitored using high-speed schlieren imaging in a recently developed technique, laser-induced air shock from energetic materials (LASEM). The method enables the estimation of detonation velocities based on the measured laser-induced air-shock velocities and has previously been demonstrated for organic military explosives. Here, the LASEM technique has been extended to explosive formulations with metal additives. A comparison of the measured laser-induced air-shock velocities for TNT, RDX, DNTF, and LLM-172 doped with Al or B to the detonation velocities predicted by the thermochemical code CHEETAH for inert or active metal participation demonstrates that LASEM has potential for predicting the early time (< 10 mu s) participation of metal additives in detonation events. The LASEM results show that while Al is mostly inert at early times in the detonation event (confirmed from large-scale detonation testing), B is active-and reducing the amount of hydrogen present during the early chemical reactions increases the resulting estimated detonation velocities. C1 [Gottfried, Jennifer L.; Bukowski, Eric J.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gottfried, JL (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jennifer.l.gottfried.civ@mail.mil NR 58 TC 0 Z9 0 U1 6 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B47 EP B57 DI 10.1364/AO.56.000B47 PG 11 WC Optics SC Optics GA EJ6SA UT WOS:000393347900008 PM 28157864 ER PT J AU Hamaoui, M AF Hamaoui, Moshe TI Polarized skylight navigation SO APPLIED OPTICS LA English DT Article ID CLEAR; ANGLE; PATTERNS; ATTITUDE; COMPASS; CLOUDY; SKIES AB Vehicle state estimation is an essential prerequisite for navigation. The present approach seeks to use skylight polarization to facilitate state estimation under autonomous unconstrained flight conditions. Atmospheric scattering polarizes incident sunlight such that solar position is mathematically encoded in the resulting skylight polarization pattern. Indeed, several species of insects are able to sense skylight polarization and are believed to navigate polarimetrically. Sun-finding methodologies for polarized skylight navigation (PSN) have been proposed in the literature but typically rely on calibration updates to account for changing atmospheric conditions and/or are limited to 2D operation. To address this technology gap, a gradient-based PSN solution is developed based upon the Rayleigh sky model. The solution is validated in simulation, and effects of measurement error and changing atmospheric conditions are investigated. Finally, an experimental effort is described wherein polarimetric imagery is collected, ground-truth is established through independent imager-attitude measurement, the gradient-based PSN solution is applied, and results are analyzed. C1 [Hamaoui, Moshe] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Hamaoui, M (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM moshe.hamaoui.civ@mail.mil NR 39 TC 0 Z9 0 U1 3 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B37 EP B46 DI 10.1364/AO.56.000B37 PG 10 WC Optics SC Optics GA EJ6SA UT WOS:000393347900007 PM 28157863 ER PT J AU Holthoff, EL Pellegrino, PM AF Holthoff, Ellen L. Pellegrino, Paul M. TI Development of photoacoustic sensing platforms at the Army Research Laboratory SO APPLIED OPTICS LA English DT Review ID QUANTUM-CASCADE LASER; TRACE GAS-ANALYSIS; CHEMICAL SENSOR; PULSED PHOTOACOUSTICS; SPECTROSCOPY; SOLIDS; TECHNOLOGY; EXCITATION; RESONATOR; DETECTOR AB Traditionally, chemical sensing platforms have been hampered by the opposing concerns of increasing sensor capability while maintaining a minimal package size. Current sensors, although reasonably sized, are geared to more classical chemical threats, and the ability to expand their capabilities to a broader range of emerging threats is uncertain. Recently, photoacoustic spectroscopy, employed in a sensor format, has shown enormous potential to address these ever-changing threats. Photoacoustic spectroscopy is one of the more flexible infrared spectroscopy variants, and that flexibility allows for the construction of sensors that are designed for specific tasks. The Army Research Laboratory has, for the past 14 years, engaged in research into the development of photoacoustic sensing platforms with the goal of sensor miniaturization and the detection of a variety of chemical targets both proximally and at range. This paper reviews this work. (C) 2016 Optical Society of America C1 [Holthoff, Ellen L.; Pellegrino, Paul M.] US Army Res Lab, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Holthoff, EL (reprint author), US Army Res Lab, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ellen.l.holthoff.civ@mail.mil FU Oak Ridge Associated Universities (ORAU); Army Research Laboratory (ARL) FX Oak Ridge Associated Universities (ORAU); Army Research Laboratory (ARL). NR 61 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B74 EP B84 DI 10.1364/AO.56.000B74 PG 11 WC Optics SC Optics GA EJ6SA UT WOS:000393347900012 PM 28157868 ER PT J AU Hu, SW Goldman, GH Borel-Donohue, CC AF Hu, Shuowen Goldman, Geoffrey H. Borel-Donohue, Christoph C. TI Detection of unmanned aerial vehicles using a visible camera system SO APPLIED OPTICS LA English DT Article ID LOOKING INFRARED IMAGERY; HISTOGRAMS AB Unmanned aerial vehicles (UAVs) flown by adversaries are an emerging asymmetric threat to homeland security and the military. To help address this threat, we developed and tested a computationally efficient UAV detection algorithm consisting of horizon finding, motion feature extraction, blob analysis, and coherence analysis. We compare the performance of this algorithm against two variants, one using the difference image intensity as the motion features and another using higher-order moments. The proposed algorithm and its variants are tested using field test data of a group 3 UAV acquired with a panoramic video camera in the visible spectrum. The performance of the algorithms was evaluated using receiver operating characteristic curves. The results show that the proposed approach had the best performance compared to the two algorithmic variants. (C) 2017 Optical Society of America C1 [Hu, Shuowen; Goldman, Geoffrey H.; Borel-Donohue, Christoph C.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Hu, SW (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM shuowen.hu.civ@mail.mil NR 26 TC 0 Z9 0 U1 3 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B214 EP B221 DI 10.1364/AO.56.00B214 PG 8 WC Optics SC Optics GA EJ6SA UT WOS:000393347900028 PM 28157904 ER PT J AU Meyer, DH Kunz, PD Solmeyer, N AF Meyer, David H. Kunz, Paul D. Solmeyer, Neal TI Nonlinear polarization spectroscopy of a Rydberg state for laser stabilization SO APPLIED OPTICS LA English DT Article ID ELECTROMAGNETICALLY INDUCED TRANSPARENCY; ATOMIC VAPOR; FREQUENCY STABILIZATION; SATURATION SPECTROSCOPY; DIODE; ABSORPTION AB We demonstrate modulation-free laser stabilization to an atomic Rydberg transition using nonlinear polarization spectroscopy. To stabilize a laser to the upper transition of a three-level ladder scheme, the techniques of standard polarization spectroscopy are adapted to use a narrow, nonlinear coherence feature. We obtain a subnatural line-width dispersive signal that is directly suitable for laser frequency stabilization. We examine the effect of laser polarization on the dispersive line shape. This technique stabilizes the laser to an absolute frequency reference, can be used with numerous Rydberg levels, and eliminates laser modulation, which can enable high bandwidth feedback. C1 [Meyer, David H.] Univ Maryland, Dept Phys, College Pk, MD 20742 USA. [Meyer, David H.; Kunz, Paul D.; Solmeyer, Neal] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Meyer, DH (reprint author), Univ Maryland, Dept Phys, College Pk, MD 20742 USA.; Meyer, DH (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM dihm@terpmail.umd.edu FU Oak Ridge Institute for Science and Education (ORISE) FX Oak Ridge Institute for Science and Education (ORISE). NR 21 TC 0 Z9 0 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B92 EP B96 DI 10.1364/AO.56.000B92 PG 5 WC Optics SC Optics GA EJ6SA UT WOS:000393347900014 PM 28157870 ER PT J AU Murrill, SR Franck, CC Jacobs, EL Petkie, DT De Lucia, FC AF Murrill, Steven R. Franck, Charmaine C. Jacobs, Eddie L. Petkie, Douglas T. De Lucia, Frank C. TI Enhanced MMW and SMMW/THz imaging system performance prediction and analysis tool for concealed weapon detection and pilotage obstacle avoidance SO APPLIED OPTICS LA English DT Review AB The U.S. Army Research Laboratory has continued to develop and enhance a millimeter- wave (MMW) and submillimeter-wave (SMMW)/terahertz (THz)-band imaging system performance prediction and analysis tool for both the detection and identification of concealed weaponry and for pilotage obstacle avoidance. The details of the MATLAB-based model that accounts for the effects of all critical sensor and display components, for the effects of atmospheric attenuation, concealment material attenuation, active illumination, target and background orientation, target and background thermal emission, and various imaging system architectures have been reported on in 2005, 2007, and 2011. This paper provides a comprehensive review of a newly enhanced MMW and SMMW/THz imaging system analysis and design tool that now includes an improved noise submodel for more accurate and reliable performance predictions, the capability to account for postcapture image contrast enhancement, and the capability to account for concealment material backscatter with active-illumination-based systems. Present plans for additional expansion of the model's predictive capabilities are also outlined. (C) 2017 Optical Society of America C1 [Murrill, Steven R.] US Army Res Lab, Adelphi, MD 20783 USA. [Franck, Charmaine C.] NASA Langley, Hampton, VA 23692 USA. [Jacobs, Eddie L.] Univ Memphis, Dept Elect & Comp Engn, Memphis, TN 38152 USA. [Petkie, Douglas T.] Wright State Univ, Dept Phys, Dayton, OH 45435 USA. [De Lucia, Frank C.] Ohio State Univ, Dept Phys, 174 W 18th Ave, Columbus, OH 43210 USA. RP Murrill, SR (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM steven.r.murrill2.civ@mail.mil NR 6 TC 0 Z9 0 U1 3 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B231 EP B239 DI 10.1364/AO.56.00B231 PG 9 WC Optics SC Optics GA EJ6SA UT WOS:000393347900030 PM 28157942 ER PT J AU Pan, YL Wang, CJ Beresnev, LA Yuffa, AJ Videen, G Ligon, D Santarpia, JL AF Pan, Yong-Le Wang, Chuji Beresnev, Leonid A. Yuffa, Alex J. Videen, Gorden Ligon, David Santarpia, Joshua L. TI Measurement of back-scattering patterns from single laser trapped aerosol particles in air SO APPLIED OPTICS LA English DT Article ID ELASTIC-LIGHT-SCATTERING; OPTICAL TRAP; DEFORMED DROPLETS; POLARIZATION; SIZE; INCLUSIONS; CELLS AB We demonstrate a method for measuring elastic back-scattering patterns from single laser trapped micron-sized particles, spanning the scattering angle range of theta = 167.7 degrees-180 degrees and phi = 0 degrees-360 degrees in spherical coordinates. We calibrated the apparatus by capturing light-scattering patterns of 10 mu m diameter borosilicate glass microspheres and comparing their scattered intensities with Lorenz-Mie theory. Back-scattering patterns are also presented from a single trapped Johnson grass spore, two attached Johnson grass spores, and a cluster of Johnson grass spores. The method has potential use in characterizing airborne aerosol particles, and may be used to provide back-scattering data for lidar applications. C1 [Pan, Yong-Le; Beresnev, Leonid A.; Yuffa, Alex J.; Videen, Gorden; Ligon, David] Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Wang, Chuji] Mississippi State Univ, Dept Phys & Astron, Starkville, MS 39759 USA. [Santarpia, Joshua L.] Sandia Natl Labs, Albuquerque, NM 87123 USA. RP Pan, YL (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [HDTRS1518237, HDTRA1619734]; U.S. Army Research Laboratory (ARL) FX Defense Threat Reduction Agency (DTRA) (HDTRS1518237, HDTRA1619734); U.S. Army Research Laboratory (ARL). NR 30 TC 1 Z9 1 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B1 EP B4 DI 10.1364/AO.56.0000B1 PG 4 WC Optics SC Optics GA EJ6SA UT WOS:000393347900002 PM 28157859 ER PT J AU Pilkington, SB Roberson, SD Pellegrino, PM AF Pilkington, Sherrie B. Roberson, Stephen D. Pellegrino, Paul M. TI Multiplex coherent anti-Stokes Raman scattering spectroscopy for trace chemical detection SO APPLIED OPTICS LA English DT Article ID SPECIES CONCENTRATION MEASUREMENTS; FEMTOSECOND FILAMENTATION; ENERGETIC MATERIALS; TRANSPARENT MEDIA; PHASE RETRIEVAL; CARS; SAPPHIRE; SPECTRA; PULSES; LIGHT AB Trace chemical detection is a particularly challenging problem of significant Army interest. Optical diagnostic techniques offer rapid, accurate, sensitive, and highly selective detection of hazardous materials in a variety of systems. Multiplex coherent anti-stokes Raman scattering (MCARS) spectroscopy generates a complete Raman spectrum from the material of interest using a combination of a supercontinuum pulse, which drives multiple molecular vibrations simultaneously, and a narrowband probe pulse. In this study, we demonstrated the ability of MCARS to detect trace amounts of both explosive materials and chemical warfare agent simulants with limits of detection below 0.2 ng and 0.1 nl, respectively. Integration times were on the order of 10 ms, using a compact USB spectrometer. Characteristics of supercontinuum generation were studied and compared to results in the literature. Finally, an algorithm that utilizes a combination of the maximum entropy method and advanced Fourier filtering to analytically remove the non-resonant background from the MCARS spectra without any a priori knowledge of the vibrational spectrum of the material of interest. (C) 2016 Optical Society of America C1 [Pilkington, Sherrie B.; Roberson, Stephen D.; Pellegrino, Paul M.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Pilkington, Sherrie B.] Natl Acad Sci Engn & Med, 500 5th St, Washington, DC 20001 USA. [Roberson, Stephen D.] EOIR Technol Inc, 10300 Spotsylvania Ave,Suite 420, Fredericksburg, VA 22408 USA. RP Pilkington, SB (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.; Pilkington, SB (reprint author), Natl Acad Sci Engn & Med, 500 5th St, Washington, DC 20001 USA. EM sherrie.s.bowman.ctr@mail.mil FU Defense Threat Reduction Agency (DTRA) [CB4059] FX Defense Threat Reduction Agency (DTRA) (CB4059). NR 53 TC 0 Z9 0 U1 4 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B159 EP B168 DI 10.1364/AO.56.00B159 PG 10 WC Optics SC Optics GA EJ6SA UT WOS:000393347900022 PM 28157878 ER PT J AU Pritchett, TM Hoffman, RC Mott, AG Ferry, MJ AF Pritchett, Timothy M. Hoffman, Robert C. Mott, Andrew G. Ferry, Michael J. TI Fluence-induced reversal of saturable absorption in a ruthenium-based porphyrin SO APPLIED OPTICS LA English DT Article ID NONLINEAR ABSORPTION AB Experimental nonlinear absorption data obtained using the open-aperture Z-scan technique are presented for 2, 3, 7, 8, 12, 17, 18-octaethyl-21H, 23H-porphine ruthenium (II) carbonyl in tetrahydrofuran. These data show saturation of nonlinear absorption dominating at low fluence but being overcome by induced absorption (reverse saturable absorption) at high fluence. Large-angle scattering measurements demonstrate that the induced absorption is real and not merely the result of scattering of light outside of the collection aperture of the detector by scattering centers induced at high fluence. A possible mechanism based on a four-band effective rate equation model is proposed. The model is used to accurately predict the results of Z scans taken at different pulse energies and to extract values for excited-state lifetimes and absorption cross sections from the experimental data. (C) 2016 Optical Society of America C1 [Pritchett, Timothy M.] US Army Int Technol Ctr Argentina, 3130 Buenos Aires Pl, Washington, DC 20521 USA. [Pritchett, Timothy M.; Hoffman, Robert C.; Mott, Andrew G.; Ferry, Michael J.] US Army Res Lab, RDRL SEE L, Powder Mill Rd, Adelphi, MD 20783 USA. RP Hoffman, RC (reprint author), US Army Res Lab, RDRL SEE L, Powder Mill Rd, Adelphi, MD 20783 USA. EM robert.c.hoffman.civ@mail.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B14 EP B17 DI 10.1364/AO.56.000B14 PG 4 WC Optics SC Optics GA EJ6SA UT WOS:000393347900004 PM 28157858 ER PT J AU Sarney, WL Svensson, SP Ting, M Segercrantz, N Walukiewicz, W Yu, KM Martin, RW Novikov, SV Foxon, CT AF Sarney, Wendy L. Svensson, Stefan P. Ting, Min Segercrantz, Natalie Walukiewicz, Wladek Yu, Kin Man Martin, Robert W. Novikov, Sergei V. Foxon, C. T. TI Intermixing studies in GaN1-xSbx highly mismatched alloys SO APPLIED OPTICS LA English DT Article ID MOLECULAR-BEAM EPITAXY; GAN-RICH SIDE; LUMINESCENCE EFFICIENCY; GROWTH; SURFACTANTS AB GaN1-xSbx with x similar to 5%-7% is a highly mismatched alloy predicted to have favorable properties for application as an electrode in a photoelectrochemical cell for solar water splitting. In this study, we grew GaN1-xSbx under conditions intended to induce phase segregation. Prior experiments with the similar alloy GaN1-xAsx, the tendency of Sb to surfact, and the low growth temperatures needed to incorporate Sb all suggested that GaN1-xSbx alloys would likely exhibit phase segregation. We found that, except for very high Sb compositions, this was not the case and that instead interdiffusion dominated. Characteristics measured by optical absorption were similar to intentionally grown bulk alloys for the same composition. Furthermore, the alloys produced by this method maintained crystallinity for very high Sb compositions and allowed higher overall Sb compositions. This method may allow higher temperature growth while still achieving needed Sb compositions for solar water splitting applications. (C) 2016 Optical Society of America C1 [Sarney, Wendy L.; Svensson, Stefan P.] US Army Res Lab, RDRL SEE I, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Ting, Min; Segercrantz, Natalie; Walukiewicz, Wladek; Yu, Kin Man] Lawrence Berkeley Natl Lab, Div Mat Sci, 1 Cyclotron Rd, Berkeley, CA 94720 USA. [Segercrantz, Natalie] Aalto Univ, Sch Sci, Dept Appl Phys, POB 15100, FI-00076 Aalto, Finland. [Yu, Kin Man] City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China. [Martin, Robert W.] Univ Strathclyde, SUPA, Dept Phys, Glasgow G4 0NG, Lanark, Scotland. [Novikov, Sergei V.; Foxon, C. T.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England. [Ting, Min] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA. RP Sarney, WL (reprint author), US Army Res Lab, RDRL SEE I, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM wendy.l.sarney.civ@mail.mil FU Engineering and Physical Sciences Research Council (EPSRC) [EP/I004203/1]; U.S. Army Research Office (ARO); ITC-Atlantic [W911NF-12-2-0003]; U.S. Department of Energy (DOE), Office of Science, Basic Energy Sciences, Materials Sciences and Engineering Division [DE-AC02-05CH11231]; General Research Fund of the Research Grants Council of Hong Kong SAR, China [11303715] FX Engineering and Physical Sciences Research Council (EPSRC) (EP/I004203/1); U.S. Army Research Office (ARO) and ITC-Atlantic (W911NF-12-2-0003); U.S. Department of Energy (DOE), Office of Science, Basic Energy Sciences, Materials Sciences and Engineering Division (DE-AC02-05CH11231); General Research Fund of the Research Grants Council of Hong Kong SAR, China (# 11303715). NR 25 TC 1 Z9 1 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B64 EP B69 DI 10.1364/AO.56.000B64 PG 6 WC Optics SC Optics GA EJ6SA UT WOS:000393347900010 PM 28157866 ER PT J AU Sausa, RC AF Sausa, Rosario C. TI Time-resolved imaging and optical spectroscopy of plasma plumes during pulsed laser material deposition SO APPLIED OPTICS LA English DT Article ID BARIUM STRONTIUM-TITANATE; II SPECTRAL-LINES; THIN-FILMS; TRANSITION-PROBABILITIES; ABLATION; LIBS; PHOTOFRAGMENTATION; DIAGNOSTICS; YBA2CU3O7-X; IONIZATION AB We employ fast imaging photography and emission spectroscopy to study plasma plumes resulting from the 248-nm ablation of barium strontium titanate, and we utilize x-ray diffraction analysis and scanning electron microscopy to characterize the deposited thin films. Hydrodynamic plume analyses yield initial velocities of approximately 20 km/s, whereas spectral simulations of the Ba I lines between 739 and 770 nm yield temperatures of approximately 17000 K at early times in vacuum. Analyses of the Stark broadened Ba II lines at 614 and 649 nm reveal an electron number density of approximately 10(+18) cm(-3) near the surface. Several Pa of oxygen reduces these values while improving the film quality. C1 [Sausa, Rosario C.] US Army Res Lab, RDRL WML B, Aberdeen, MD 21005 USA. RP Sausa, RC (reprint author), US Army Res Lab, RDRL WML B, Aberdeen, MD 21005 USA. EM rosario.c.sausa.civ@mail.mil NR 58 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B123 EP B133 DI 10.1364/AO.56.00B123 PG 11 WC Optics SC Optics GA EJ6SA UT WOS:000393347900018 PM 28157875 ER PT J AU Shensky, WM Ferry, MJ O'Donnell, RM Ensley, TR Shi, JM AF Shensky, William M., III Ferry, Michael J. O'Donnell, Ryan M. Ensley, Trenton R. Shi, Jianmin TI Nonlinear optical characterization of multinuclear iridium compounds containing tricycloquinazoline SO APPLIED OPTICS LA English DT Article ID 2-PHOTON ABSORPTION; DATA STORAGE; COMPLEXES; DESIGN; DYES AB Nonlinear optical properties were characterized for a series of multinuclear iridium compounds of the form TCQ[Ir-III(ppz)(2)](n), where n = 1, 2, or 3, TCQ is tricycloquinazoline, and ppz is 1-phenylpyrazole. Transient absorption (TA) spectroscopy indicated that the triplet metal-to-ligand charge transfer excited state was formed on a subpicosecond time scale and decayed back to the ground state on a microsecond time scale, consistent with precedents in the literature. TA bands were observed for all three compounds from 475 to 900 nm, implying the potential for reverse-saturable absorption ( RSA) at those wavelengths. Z-scan measurements using picosecond and nanosecond pulses were obtained at 532 nm and confirmed the presence of RSA behavior for all three compounds. The triplet excited state cross sections and the RSA figure of merit were found to decrease with increasing n: 1 > 2 similar to 3. C1 [Shensky, William M., III; Ferry, Michael J.; O'Donnell, Ryan M.; Ensley, Trenton R.; Shi, Jianmin] US Army Res Lab, Attn RDRL SEE L, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Shensky, WM (reprint author), US Army Res Lab, Attn RDRL SEE L, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM william.m.shensky.civ@mail.mil FU Army Research Laboratory (ARL) [STO-R R.C3I.2015.01] FX Army Research Laboratory (ARL) (STO-R R.C3I.2015.01). NR 27 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B179 EP B183 DI 10.1364/AO.56.00B179 PG 5 WC Optics SC Optics GA EJ6SA UT WOS:000393347900024 PM 28157880 ER PT J AU Siverns, JD Li, X Quraishi, Q AF Siverns, J. D. Li, X. Quraishi, Q. TI Ion-photon entanglement and quantum frequency conversion with trapped Ba+ ions SO APPLIED OPTICS LA English DT Article ID BELL INEQUALITY VIOLATION; SINGLE-PHOTON; UP-CONVERSION; QUBITS; ATOM; ARCHITECTURE; EFFICIENT; COMPUTER; STATES AB Trapped ions are excellent candidates for quantum nodes, as they possess many desirable features of a network node including long lifetimes, on-site processing capability, and production of photonic flying qubits. However, unlike classical networks in which data may be transmitted in optical fibers and where the range of communication is readily extended with amplifiers, quantum systems often emit photons that have a limited propagation range in optical fibers and, by virtue of the nature of a quantum state, cannot be noiselessly amplified. Here, we first describe a method to extract flying qubits from a Ba+ trapped ion via shelving to a long-lived, low-lying D-state with higher entanglement probabilities compared with current strong and weak excitation methods. We show a projected fidelity of approximate to 89% of the ion-photon entanglement. We compare several methods of ion-photon entanglement generation, and we show how the fidelity and entanglement probability varies as a function of the photon collection optic's numerical aperture. We then outline an approach for quantum frequency conversion of the photons emitted by the Ba+ ion to the telecommunication range for long-distance networking and to 780 nm for potential entanglement with rubidium-based quantum memories. Our approach is significant for extending the range of quantum networks and for the development of hybrid quantum networks compromised of different types of quantum memories. (C) 2017 Optical Society of America C1 [Siverns, J. D.; Li, X.; Quraishi, Q.] US Army Res Lab, Adelphi, MD 20783 USA. [Siverns, J. D.; Li, X.; Quraishi, Q.] Univ Maryland, Joint Quantum Inst, College Pk, MD 20742 USA. RP Quraishi, Q (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.; Quraishi, Q (reprint author), Univ Maryland, Joint Quantum Inst, College Pk, MD 20742 USA. EM qudsia.quraishi.civ@mail.mil FU Army Research Laboratory (ARL) [W911NF-14-2-0101]; ARL's Center for Distributed Quantum Information (CDQI) FX Army Research Laboratory (ARL) (W911NF-14-2-0101); ARL's Center for Distributed Quantum Information (CDQI). NR 62 TC 0 Z9 0 U1 2 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B222 EP B230 DI 10.1364/AO.56.00B222 PG 9 WC Optics SC Optics GA EJ6SA UT WOS:000393347900029 PM 28157932 ER PT J AU Svensson, SP Sarney, WL Donetsky, D Kipshidze, G Lin, YX Shterengas, L Xu, Y Belenky, G AF Svensson, Stefan P. Sarney, Wendy L. Donetsky, Dmitry Kipshidze, Gela Lin, Youxi Shterengas, Leon Xu, Ye Belenky, Gregory TI Materials design parameters for infrared device applications based on III-V semiconductors SO APPLIED OPTICS LA English DT Article ID STRAINED-LAYER SUPERLATTICES; INAS1-XSBX; DETECTORS; PROPOSAL; ALLOYS AB The collaborative development of infrared detector materials by the Army Research Laboratory and Stony Brook University has led to new fundamental understandings of materials, as well as new levels of control and flexibility in III-V semiconductor crystal growth by molecular beam epitaxy. Early work on mid-wave strained layer superlattice (SLS) cameras led to a subsequent focus on minority carrier lifetime studies, which resulted in the proposal of the Ga-free SLS on GaSb substrates. The later demonstration of virtual substrate technology allowed the lattice constant to become a design parameter and enabled growth of undistorted bulk InAsSb. When grown in that manner, InAsSb has a bandgap bowing parameter large enough to cover absorption wavelengths across the entire long-wavelength band (8 - 12 mu m). Even longer wavelengths are achieved with a general Ga-free SLS approach, with a virtual substrate having a lattice constant significantly larger than that of GaSb and with InAsSb in both bilayers in the period. Since these layers can also be made very thin, the general Ga-free SLS does not suffer from the relatively low optical absorption and poor hole transport, which is characteristic of the special Ga-free SLS on GaSb for long-wavelength designs. Finally, the general Ga-free InAsSb SLS provides a method to induce and control sustained atomic ordering, which is yet another new design parameter. (C) 2016 Optical Society of America C1 [Svensson, Stefan P.; Sarney, Wendy L.] US Army Res Lab, Adelphi, MD 20783 USA. [Donetsky, Dmitry; Kipshidze, Gela; Lin, Youxi; Shterengas, Leon; Xu, Ye; Belenky, Gregory] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. RP Svensson, SP (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. EM stefan.p.svensson.civ@mail.mil FU National Science Foundation (NSF) [DMR1160843]; Army Research Office (ARO) [W911NF1620053] FX National Science Foundation (NSF) (DMR1160843); Army Research Office (ARO) (W911NF1620053). NR 32 TC 0 Z9 0 U1 3 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B58 EP B63 DI 10.1364/AO.56.000B58 PG 6 WC Optics SC Optics GA EJ6SA UT WOS:000393347900009 PM 28157865 ER PT J AU Ter-Gabrielyan, N Fromzel, V AF Ter-Gabrielyan, Nikolay Fromzel, Viktor TI Wavelength tuning in cryogenically cooled lasers based on Er-doped orthovanadates SO APPLIED OPTICS LA English DT Article ID OPTICAL SPECTROSCOPY; CRYSTALS; YVO4 AB Continuous tuning between 1590 and 1612 nm has been demonstrated in cryogenically cooled lasers with composite active media consisting of Er: YVO4, Er: LuVO4, and Er: GdVO4 crystals resonantly pumped by a fiber-coupled laser diode emitting at 1529 nm. Wavelength tuning was implemented using an intracavity single-plate birefringent filter. (C) 2016 Optical Society of America C1 [Ter-Gabrielyan, Nikolay; Fromzel, Viktor] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Ter-Gabrielyan, N (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nikolay.e.ter-gabrielyan.civ@mail.mil NR 17 TC 0 Z9 0 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B70 EP B73 DI 10.1364/AO.56.000B70 PG 4 WC Optics SC Optics GA EJ6SA UT WOS:000393347900011 PM 28157867 ER PT J AU White, JO Harfouche, M Edgecumbe, J Satyan, N Rakuljic, G Jayaraman, V Burgner, C Yariv, A AF White, Jeffrey O. Harfouche, Mark Edgecumbe, John Satyan, Naresh Rakuljic, George Jayaraman, Vijay Burgner, Christopher Yariv, Amnon TI 1.6 kW Yb fiber amplifier using chirped seed amplification for stimulated Brillouin scattering suppression SO APPLIED OPTICS LA English DT Article ID SBS-THRESHOLD; OPTICAL-FIBERS; TEMPERATURE; INCREASE; ALUMINA AB In a high power fiber amplifier, a frequency-chirped seed interrupts the coherent interaction between the laser and Stokes waves, raising the threshold for stimulated Brillouin scattering (SBS). Moving the external mirror of a vertical cavity surface-emitting diode laser 0.2 mu m in 10 mu s can yield a frequency chirp of 5 x 10(17) Hz/s of a nearly constant output power. Opto-electronic feedback loops can linearize the chirp, and stabilize the output power. The linear variation of phase with time allows multiple amplifiers to be coherently combined using a frequency shifter to compensate for static and dynamic path length differences. The seed bandwidth, as seen by the counter-propagating SBS, also increases linearly with fiber length, resulting in a nearly-length-independent SBS threshold. Experimental results at the 1.6 kW level with a 19 m delivery fiber are presented. A numerical simulation is also presented. (C) 2016 Optical Society of America C1 [White, Jeffrey O.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Harfouche, Mark; Yariv, Amnon] CALTECH, Dept Elect Engn, 1200 E Calif Blvd, Pasadena, CA 91125 USA. [Edgecumbe, John] Nufern, 7 Airport Pk Rd, E Granby, CT 06026 USA. [Satyan, Naresh; Rakuljic, George] Telaris Inc, 2118 Wilshire Blvd 238, Santa Monica, CA 90403 USA. [Jayaraman, Vijay; Burgner, Christopher] Praevium Res Inc, 5330 Debbie Rd,Suite 100, Santa Barbara, CA 93111 USA. RP White, JO (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jeffrey.o.white@osamember.org FU High Energy Laser Joint Technology Office [13-SA-0509]; U.S. Army Research Office (ARO) [W911NF-11-2-0081] FX High Energy Laser Joint Technology Office (13-SA-0509); U.S. Army Research Office (ARO) (W911NF-11-2-0081). NR 21 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B116 EP B122 DI 10.1364/AO.56.00B116 PG 7 WC Optics SC Optics GA EJ6SA UT WOS:000393347900017 PM 28157874 ER PT J AU Yuffa, AJ Kaydash, V Korokhin, V Shkuratov, Y Zubko, E Videen, G AF Yuffa, Alex J. Kaydash, Vadym Korokhin, Viktor Shkuratov, Yuriy Zubko, Evgenij Videen, Gorden TI Phase-ratio imaging as applied to desert sands for tracking human presence SO APPLIED OPTICS LA English DT Article ID LUNAR; IMAGERY; SURFACE; PROBES; ENIGMA; MOON AB The phase function is a measure of the light-scattered intensity, or radiance, as a function of scattering angle.. A phase ratio is the ratio of two values of the phase function measured at different scattering angles and relates to the slope of the phase function. By taking the ratio of two images acquired at different illumination or observation conditions, a phase-ratio image can be constructed. Such images accentuate differences in the phase curves, rather than their intensities, and are more sensitive to microtopography than to material properties. We produce phase-ratio images from intensity images acquired at different observation times and locations in the desert environment of White Sands National Monument. Because of the lack of surface features, coregistration of the images is challenging, especially for images acquired from different observation locations. However, we do demonstrate that phase-ratio images can be used to identify disturbed sands. We also produce polarimetric and color-ratio images. These latter images do not suggest the possibility of identifying topographical differences due to human presence. C1 [Yuffa, Alex J.; Videen, Gorden] Army Res Lab AMSRL CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Kaydash, Vadym; Korokhin, Viktor; Shkuratov, Yuriy] Kharkiv VN Karazin Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. [Zubko, Evgenij] Far Eastern Fed Univ, Sch Nat Sci, 8 Sukhanova St, Vladivostok 690950, Russia. RP Videen, G (reprint author), Army Res Lab AMSRL CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Gorden.W.Videen.civ@mail.mil FU Army Research Office (ARO) [W911NF-16-2-0111] FX Army Research Office (ARO) (W911NF-16-2-0111). NR 18 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B184 EP B190 DI 10.1364/AO.56.00B184 PG 7 WC Optics SC Optics GA EJ6SA UT WOS:000393347900025 PM 28157882 ER PT J AU Zhou, WM Stead, M Weiss, S Okusaga, O Jiang, LJ Anderson, S Huang, ZR AF Zhou, Weimin Stead, Michael Weiss, Steven Okusaga, Olukayode Jiang, Lingjun Anderson, Stephen Huang, Z. Rena TI Developing an integrated photonic system with a simple beamforming architecture for phased-array antennas SO APPLIED OPTICS LA English DT Article ID TRUE-TIME-DELAY; GRATINGS; PRISM AB We have designed a simplified true-time-delay beamforming architecture using integrated photonics for phasedarray antennas. This architecture can independently control multiple RF beams simultaneously with only a single tuning parameter to steer the beam in each direction for each beam. We have made a proof-of-the-principle demonstration of an X-band, 30 x 4-elements, fiber-optics-based beamformer for one-dimensional steering in transmission mode. The goal is to develop a semiconductor-based integrated photonic circuit so that a 2D beamforming array for both transmit and receive operations can be made on a single chip. For that, we have designed a Si-based integrated waveguide circuit using two types of "slow-light" waveguide for tunable time delays for two-dimensional steering. (C) 2016 Optical Society of America C1 [Zhou, Weimin; Stead, Michael; Weiss, Steven; Anderson, Stephen] US Army Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Okusaga, Olukayode] Johns Hopkins Univ, Appl Phys Lab, Johns Hopkins Rd, Laurel, MD 20723 USA. [Jiang, Lingjun; Anderson, Stephen; Huang, Z. Rena] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. RP Zhou, WM (reprint author), US Army Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM weimin.zhou.civ@mail.mil FU U.S. Army Research Laboratory (ARL) Cooperative Agreement [W911NF-16-2-0049] FX U.S. Army Research Laboratory (ARL) Cooperative Agreement (W911NF-16-2-0049). NR 24 TC 0 Z9 0 U1 7 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2017 VL 56 IS 3 BP B5 EP B13 DI 10.1364/AO.56.0000B5 PG 9 WC Optics SC Optics GA EJ6SA UT WOS:000393347900003 PM 28157860 ER PT J AU Akhvlediani, T Bautista, CT Garuchava, N Sanodze, L Kokaia, N Malania, L Chitadze, N Sidamonidze, K Rivard, RG Hepburn, MJ Nikolich, MP Imnadze, P Trapaidze, N AF Akhvlediani, Tamar Bautista, Christian T. Garuchava, Natalia Sanodze, Lia Kokaia, Nora Malania, Lile Chitadze, Nazibrola Sidamonidze, Ketevan Rivard, Robert G. Hepburn, Matthew J. Nikolich, Mikeljon P. Imnadze, Paata Trapaidze, Nino TI Epidemiological and Clinical Features of Brucellosis in the Country of Georgia SO PLOS ONE LA English DT Article ID NEIGHBORING COMMUNITY MEMBERS; DIAGNOSIS; MANIFESTATIONS; EGYPT; TESTS; PCR AB Background Brucellosis is an endemic disease in the country of Georgia. According to the National Center for Disease Control and Public Health of Georgia (NCDC), the average annual number of brucellosis cases was 161 during 2008-2012. However, the true number of cases is thought to be higher due to underreporting. The aim of this study was to provide current epidemiological and clinical information and evaluate diagnostic methods used for brucellosis in Georgia. Methodology Adult patients were eligible for participation if they met the suspected or probable case definition for brucellosis. After consent participants were interviewed using a standardized questionnaire to collect information on socio-demographic characteristics, epidemiology, history of present illness, and clinical manifestation. For the diagnosis of brucellosis, culture and serological tests were used. Results A total of 81 participants were enrolled, of which 70 (86%) were from rural areas. Seventy-four percent of participants reported consuming unpasteurized milk products and 62% consuming undercooked meat products before symptom onset. Forty-one participants were positive by the Wright test and 33 (41%) were positive by blood culture. There was perfect agreement between the Huddelston and Wright tests (k = 1.0). Compared with blood culture (the diagnostic gold standard), ELISA IgG and total ELISA (IgG + IgM), the Wright test had fair (k = 0.12), fair (k = 0.24), and moderate (k = 0.52) agreement, respectively. Conclusions Consumption of unpasteurized milk products and undercooked meat were among the most common risk factors in brucellosis cases. We found poor agreement between ELISA tests and culture results. This report also serves as an initial indication that the suspected case definition for brucellosis surveillance purposes needs revision. Further research is needed to characterize the epidemiology and evaluate the performance of the diagnostic methods for brucellosis in Georgia. C1 [Akhvlediani, Tamar; Nikolich, Mikeljon P.; Trapaidze, Nino] USAMRD G, Tbilisi, Rep of Georgia. [Bautista, Christian T.; Nikolich, Mikeljon P.] WRAIR, Silver Spring, MD USA. [Garuchava, Natalia; Sanodze, Lia; Malania, Lile; Chitadze, Nazibrola; Sidamonidze, Ketevan; Imnadze, Paata; Trapaidze, Nino] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. [Kokaia, Nora] Virsaladze Sci Res Inst Med Parasitol & Trop Med, Tbilisi, Rep of Georgia. [Sidamonidze, Ketevan] I Javakhishvili Tbilisi State Univ, Tbilisi, Rep of Georgia. [Rivard, Robert G.; Hepburn, Matthew J.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM t_akhvlediani@yahoo.com FU Defense Threat Reduction Agency (DTRA) through the Cooperative Biological Engagement Program [CBEP-CBR-GG17] FX This study was funded by the Defense Threat Reduction Agency (DTRA) through the Cooperative Biological Engagement Program (CBEP-CBR-GG17). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 26 TC 0 Z9 0 U1 9 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 20 PY 2017 VL 12 IS 1 AR e0170376 DI 10.1371/journal.pone.0170376 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EI3QC UT WOS:000392405300121 PM 28107444 ER PT J AU Hartley, DJ Riedinger, LL Janssens, RVF Majola, SNT Riley, MA Allmond, JM Beausang, CW Carpenter, MP Chiara, CJ Cooper, N Curien, D Gall, BJP Garrett, PE Kondev, FG Kulp, WD Lauritsen, T McCutchan, EA Miller, D Miller, S Piot, J Redon, N Sharpey-Schafer, JF Simpson, J Stefanescu, I Wang, X Werner, V Wood, JL Yu, CH Zhu, S Dudek, J AF Hartley, D. J. Riedinger, L. L. Janssens, R. V. F. Majola, S. N. T. Riley, M. A. Allmond, J. M. Beausang, C. W. Carpenter, M. P. Chiara, C. J. Cooper, N. Curien, D. Gall, B. J. P. Garrett, P. E. Kondev, F. G. Kulp, W. D. Lauritsen, T. McCutchan, E. A. Miller, D. Miller, S. Piot, J. Redon, N. Sharpey-Schafer, J. F. Simpson, J. Stefanescu, I. Wang, X. Werner, V. Wood, J. L. Yu, C. -H. Zhu, S. Dudek, J. TI Investigation of negative-parity states in Dy-156: Search for evidence of tetrahedral symmetry SO PHYSICAL REVIEW C LA English DT Article ID NUCLEAR-DATA SHEETS; COINCIDENCE DATA; SPIN; MODEL AB An experiment populating low/medium-spin states in Dy-156 was performed to investigate the possibility of tetrahedral symmetry in this nucleus. In particular, focus was placed on the low-spin, negative-parity states since recent theoretical studies suggest that these may be good candidates for this high-rank symmetry. The states were produced in the Nd-148(C-12, 4n) reaction and the Gammasphere array was utilized to detect the emitted. rays. B(E2)/B(E1) ratios of transition probabilities from the low-spin, negative-parity bands were determined and used to interpret whether these structures are best associated with tetrahedral symmetry or, as previously assigned, to octupole vibrations. In addition, several other negative-parity structures were observed to higher spin and two new sequences were established. C1 [Hartley, D. J.] US Naval Acad, Dept Phys, Annapolis, MD 21402 USA. [Riedinger, L. L.; Miller, D.] Univ Tennessee, Dept Phys & Astron, Knoxville, TN 37996 USA. [Janssens, R. V. F.; Carpenter, M. P.; Chiara, C. J.; Lauritsen, T.; Stefanescu, I.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA. [Majola, S. N. T.] Natl Res Fdn, iThemba LABS, POB 722, ZA-7129 Somerset West, South Africa. [Riley, M. A.; Miller, S.; Wang, X.] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA. [Allmond, J. M.; Beausang, C. W.] Univ Richmond, Dept Phys, Richmond, VA 23173 USA. [Allmond, J. M.; Yu, C. -H.] Oak Ridge Natl Lab, Div Phys, Oak Ridge, TN 37831 USA. [Chiara, C. J.; Stefanescu, I.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Chiara, C. J.; Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, 9700 S Cass Ave, Argonne, IL 60439 USA. [Cooper, N.; Werner, V.] Yale Univ, Wright Nucl Struct Lab, New Haven, CT 06520 USA. [Curien, D.; Gall, B. J. P.; Piot, J.; Dudek, J.] Univ Strasbourg, IPHC, 23 Rue Loess, F-67037 Strasbourg, France. [Curien, D.; Gall, B. J. P.; Piot, J.] CNRS, UMR7178, F-67037 Strasbourg, France. [Garrett, P. E.] Univ Guelph, Dept Phys, Guelph, ON N1G 2W1, Canada. [Kulp, W. D.] Georgia Inst Technol, Sch Phys, Atlanta, GA 30332 USA. [McCutchan, E. A.] Brookhaven Natl Lab, Natl Nucl Data Ctr, Upton, NY 11973 USA. [Redon, N.] Inst Phys Nucl, IN2P3, CNRS, F-69622 Villeurbanne, France. [Sharpey-Schafer, J. F.] Univ Western Cape, Dept Phys, P-B X17, ZA-7535 Bellville, South Africa. [Simpson, J.] STFC Daresbury Lab, Warrington WA4 4AD, Cheshire, England. [Dudek, J.] Marie Curie Sklodowska Univ, Inst Phys, PL-20031 Lublin, Poland. [Chiara, C. J.] US Army Res Lab, Adelphi, MD 20783 USA. [Miller, D.] Idaho Natl Lab, Idaho Falls, ID 83402 USA. [Wang, X.] Calif Polytech State Univ San Luis Obispo, Dept Phys, San Luis Obispo, CA 93407 USA. [Werner, V.] Tech Univ Darmstadt, Inst Kernphys, D-64289 Darmstadt, Germany. RP Hartley, DJ (reprint author), US Naval Acad, Dept Phys, Annapolis, MD 21402 USA. RI Werner, Volker/C-1181-2017 OI Werner, Volker/0000-0003-4001-0150 FU National Science Foundation [PHY-1203100, PHY-0754674]; U.S. Department of Energy, Office of Science, Office of Nuclear Physics [DE-AC02-06CH11357, DE-FG02-94ER40848, DE-FG02-96ER40983, DE-FG02-91ER40609, DE-AC02-98CD10886, DE-FG02-94ER40834]; UK Science and Technology Council (STFC); Joyce Frances Adlard Cultural Fund FX The authors thank the ANL operations staff at Gammasphere and gratefully acknowledge the efforts of J. P. Greene for target preparation. We thank D. C. Radford and H. Q. Jin for their software support. This work is funded by the National Science Foundation under Grant Nos. PHY-1203100 (USNA) and PHY-0754674 (FSU), as well as by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics, under Contract No. DE-AC02-06CH11357 (ANL), and under award nos. DE-FG02-94ER40848 (UML), DE-FG02-96ER40983 (UT), DE-FG02-91ER40609 (Yale), DE-AC02-98CD10886 (BNL), and DE-FG02-94ER40834 (UM). J.S. would like to acknowledge the support of the UK Science and Technology Council (STFC). J.F.S-S. acknowledges support from the Joyce Frances Adlard Cultural Fund, and S.T.N.M. acknowledges the South African National Research Foundation. This research used resources of Argonne National Laboratory's ATLAS facility, which is a U.S. Department of Energy Office of Science User Facility. NR 30 TC 0 Z9 0 U1 8 U2 8 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9985 EI 2469-9993 J9 PHYS REV C JI Phys. Rev. C PD JAN 20 PY 2017 VL 95 IS 1 AR 014321 DI 10.1103/PhysRevC.95.014321 PG 10 WC Physics, Nuclear SC Physics GA EI1YI UT WOS:000392282400001 ER PT J AU Saphire, EO Dye, JM Kobinger, GP Zeitlin, L Chandran, K Garry, RF AF Saphire, Erica Ollmann Dye, John M. Kobinger, Gary P. Zeitlin, Larry Chandran, Kartik Garry, Robert F. TI How to turn competitors into collaborators SO NATURE LA English DT Editorial Material C1 [Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, Ctr Excellence Global Virus Network, La Jolla, CA 92037 USA. [Dye, John M.] US Army, Med Res Inst Infect Dis, Viral Immunol, Ft Detrick, MD 21702 USA. [Kobinger, Gary P.] Univ Laval, Dept Microbiol Immunol & Infect Dis, Quebec City, PQ, Canada. [Zeitlin, Larry] Mapp Biopharmaceut, San Diego, CA USA. [Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, New York, NY USA. [Garry, Robert F.] Tulane Univ, Dept Microbiol & Immunol, New Orleans, LA USA. RP Saphire, EO (reprint author), Scripps Res Inst, Dept Immunol & Microbial Sci, Ctr Excellence Global Virus Network, La Jolla, CA 92037 USA. NR 1 TC 0 Z9 0 U1 5 U2 5 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD JAN 19 PY 2017 VL 541 IS 7637 BP 283 EP 285 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EN6QP UT WOS:000396128800014 PM 28102273 ER PT J AU Johnson, DF Mullin, JM Mattson, WD AF Johnson, Donald F. Mullin, Jonathan M. Mattson, William D. TI High-Velocity Collisions of Nanodiamond SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID GENERALIZED GRADIENT APPROXIMATION; DIAMOND; CARBON; STATE AB Nanodiamond (ND) is a unique material that exhibits interesting surface properties and is capable of storing strain energy. Molecular dynamics simulations using density functional theory were performed on a variety of ND particles, some of which were constructed to specifically incorporate internal strain. The unstrained spherical ND structures were carved out of bulk crystals and relaxed, while the ND with built-in internal strain were constructed as a dense core (compressive strain) encompassed by a thin shell (tensile strain). Both on-axis and off-axis collisions were simulated at 10 km/s relative velocity. Impact energy was enough to partially melt and shatter the ND particles. Upon impact, the outer shell was ruptured and the release of the strained core energy accelerated expansion compared to previous work on bulk-like ND particles. The internal strain also led to greater fragmentation and an increase in the number of reactive surfaces. C1 [Johnson, Donald F.; Mullin, Jonathan M.; Mattson, William D.] Army Res Lab, Weap & Mat Res Directorate, RDRL WML B, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. [Mullin, Jonathan M.] DCI Solut, Aberdeen Proving Ground, MD 21005 USA. RP Mullin, JM; Mattson, WD (reprint author), Army Res Lab, Weap & Mat Res Directorate, RDRL WML B, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA.; Mullin, JM (reprint author), DCI Solut, Aberdeen Proving Ground, MD 21005 USA. EM jmullin@DCI-solutions.com; william.d.mattson6.civ@mail.mil FU Army Research Laboratory [W911NF-12-2-0019] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-12-2-0019. Computer time was provided via the HPCMP project: Chemistry and Physics of Energetic Materials. Calculations were performed at DoD Supercomputing Resource Centers located at the Information Technology Laboratory, Vicksburg, MS and at the Army Research Laboratory in Aberdeen, MD. All figures were created using OVITO. NR 28 TC 0 Z9 0 U1 7 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JAN 19 PY 2017 VL 121 IS 2 BP 1140 EP 1145 DI 10.1021/acs.jpcc.6b09917 PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA EI5SD UT WOS:000392554000018 ER PT J AU Assmy, P Fernandez-Mendez, M Duarte, P Meyer, A Randelhoff, A Mundy, CJ Olsen, LM Kauko, HM Bailey, A Chierici, M Cohen, L Doulgeris, AP Ehn, JK Fransson, A Gerland, S Hop, H Hudson, SR Hughes, N Itkin, P Johnsen, G King, JA Koch, BP Koenig, Z Kwasniewski, S Laney, SR Nicolaus, M Pavlov, AK Polashenski, CM Provost, C Rosel, A Sandbu, M Spreen, G Smedsrud, LH Sundfjord, A Taskjelle, T Tatarek, A Wiktor, J Wagner, PM Wold, A Steen, H Granskog, MA AF Assmy, Philipp Fernandez-Mendez, Mar Duarte, Pedro Meyer, Amelie Randelhoff, Achim Mundy, Christopher J. Olsen, Lasse M. Kauko, Hanna M. Bailey, Allison Chierici, Melissa Cohen, Lana Doulgeris, Anthony P. Ehn, Jens K. Fransson, Agneta Gerland, Sebastian Hop, Haakon Hudson, Stephen R. Hughes, Nick Itkin, Polona Johnsen, Geir King, Jennifer A. Koch, Boris P. Koenig, Zoe Kwasniewski, Slawomir Laney, Samuel R. Nicolaus, Marcel Pavlov, Alexey K. Polashenski, Christopher M. Provost, Christine Rosel, Anja Sandbu, Marthe Spreen, Gunnar Smedsrud, Lars H. Sundfjord, Arild Taskjelle, Torbjorn Tatarek, Agnieszka Wiktor, Jozef Wagner, Penelope M. Wold, Anette Steen, Harald Granskog, Mats A. TI Leads in Arctic pack ice enable early phytoplankton blooms below snow-covered sea ice SO SCIENTIFIC REPORTS LA English DT Article ID EASTERN FRAM STRAIT; ORGANIC-CARBON; BARENTS SEA; PHAEOCYSTIS-POUCHETII; VERTICAL EXPORT; OCEAN; EFFICIENCY; INCREASES; SVALBARD; PLANKTON AB The Arctic icescape is rapidly transforming from a thicker multiyear ice cover to a thinner and largely seasonal first-year ice cover with significant consequences for Arctic primary production. One critical challenge is to understand how productivity will change within the next decades. Recent studies have reported extensive phytoplankton blooms beneath ponded sea ice during summer, indicating that satellite-based Arctic annual primary production estimates may be significantly underestimated. Here we present a unique time-series of a phytoplankton spring bloom observed beneath snow-covered Arctic pack ice. The bloom, dominated by the haptophyte algae Phaeocystis pouchetii, caused near depletion of the surface nitrate inventory and a decline in dissolved inorganic carbon by 16 +/- 6 g Cm-2. Ocean circulation characteristics in the area indicated that the bloom developed in situ despite the snow-covered sea ice. Leads in the dynamic ice cover provided added sunlight necessary to initiate and sustain the bloom. Phytoplankton blooms beneath snow-covered ice might become more common and widespread in the future Arctic Ocean with frequent lead formation due to thinner and more dynamic sea ice despite projected increases in high-Arctic snowfall. This could alter productivity, marine food webs and carbon sequestration in the Arctic Ocean. C1 [Assmy, Philipp; Fernandez-Mendez, Mar; Duarte, Pedro; Meyer, Amelie; Randelhoff, Achim; Olsen, Lasse M.; Kauko, Hanna M.; Bailey, Allison; Cohen, Lana; Fransson, Agneta; Gerland, Sebastian; Hop, Haakon; Hudson, Stephen R.; Itkin, Polona; King, Jennifer A.; Pavlov, Alexey K.; Rosel, Anja; Spreen, Gunnar; Sundfjord, Arild; Wold, Anette; Steen, Harald; Granskog, Mats A.] Fram Ctr, Norwegian Polar Inst, N-9296 Tromso, Norway. [Randelhoff, Achim; Hop, Haakon] UiT Arctic Univ Norway, Fac Biosci Fisheries & Econ, Dept Arctic & Marine Biol, N-9037 Tromso, Norway. [Mundy, Christopher J.; Ehn, Jens K.] Univ Manitoba, Ctr Earth Observat Sci, Winnipeg, MB R3T 2N2, Canada. [Chierici, Melissa] Inst Marine Res, N-9019 Tromso, Norway. [Doulgeris, Anthony P.] UiT Arctic Univ Norway, Fac Sci & Technol, Dept Phys & Technol, N-9037 Tromso, Norway. [Hughes, Nick; Wagner, Penelope M.] Norwegian Meteorol Inst, N-9239 Tromso, Norway. [Johnsen, Geir; Sandbu, Marthe] Norwegian Univ Sci & Technol, Ctr Autonomous Marine Operat & Syst, Dept Biol, N-7491 Trondheim, Norway. [Johnsen, Geir] Univ Ctr Svalbard, Post Box 156, N-9171 Longyearbyen, Norway. [Koch, Boris P.; Nicolaus, Marcel] Helmholtz Ctr Polar & Marine Res, Alfred Wegener Inst, D-27570 Bremerhaven, Germany. [Koenig, Zoe; Provost, Christine] Pierre & Marie Curie Univ, CNRS, UMR 7159, LOCEAN,MNHN,IRD, Paris, France. [Kwasniewski, Slawomir; Tatarek, Agnieszka; Wiktor, Jozef] Polish Acad Sci, Inst Oceanol, PL-81712 Sopot, Poland. [Laney, Samuel R.] Woods Hole Oceanog Inst, Dept Biol, Woods Hole, MA 02543 USA. [Polashenski, Christopher M.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Spreen, Gunnar] Univ Bremen, Inst Environm Phys, D-28334 Bremen, Germany. [Smedsrud, Lars H.] Bjerknes Ctr Climate Res, N-5007 Bergen, Norway. [Smedsrud, Lars H.] Univ Bergen, Inst Geophys, N-5007 Bergen, Norway. [Taskjelle, Torbjorn] Univ Bergen, Dept Phys & Technol, N-5007 Bergen, Norway. RP Assmy, P (reprint author), Fram Ctr, Norwegian Polar Inst, N-9296 Tromso, Norway. EM Philipp.Assmy@npolar.no RI Koch, Boris/B-2784-2009; OI Koch, Boris/0000-0002-8453-731X; Meyer, Amelie/0000-0003-0447-795X; Olsen, Lasse Mork/0000-0003-1328-2687; Randelhoff, Achim/0000-0001-7947-9090 FU Centre for Ice, Climate and Ecosystems (ICE) at the Norwegian Polar Institute; Ministry of Climate and Environment, Norway; Research Council of Norway [244646, 221961, 222681, 237906, 223254]; Ministry of Foreign Affairs, Norway; ICE-ARC program of the European Union 7th Framework Program [603887]; Polish-Norwegian Research Program [Pol-Nor/197511/40/2013]; Ocean Acidification Flagship program within the FRAM-High North Research Centre for Climate and the Environment, Norway FX We are indebted to the captains and crew of RV Lance. This study was supported by the Centre for Ice, Climate and Ecosystems (ICE) at the Norwegian Polar Institute, the Ministry of Climate and Environment, Norway, the Research Council of Norway (projects Boom or Bust no. 244646, STASIS no. 221961, CORESAT no. 222681, CIRFA no. 237906 and AMOS CeO no. 223254), and the Ministry of Foreign Affairs, Norway (project ID Arctic), the ICE-ARC program of the European Union 7th Framework Program (grant number 603887), the Polish-Norwegian Research Program operated by the National Centre for Research and Development under the Norwegian Financial Mechanism 2009-2014 in the frame of Project Contract Pol-Nor/197511/40/2013, CDOM-IIEAT, and the Ocean Acidification Flagship program within the FRAM-High North Research Centre for Climate and the Environment, Norway. The ALOS-2 Palsar-2 scene was provided by JAXA under the 4th Research Announcement program. Radarsat-2 data were provided by NSC/KSAT under the Norwegian-Canadian Radarsat agreement 2015. Thanks also to Max Konig, Thomas Kramer and Malin Johansson for coordination of satellite acquisitions during N-ICE2015. We thank the Norwegian Meteorological Institute for ice chart data and the crew from Airlift that undertook the helicopter operations. We kindly acknowledge three anonymous reviewers and the editors of Scientific Reports for their valuable comments on the manuscript. NR 47 TC 1 Z9 1 U1 23 U2 23 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JAN 19 PY 2017 VL 7 AR 40850 DI 10.1038/srep40850 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EI1FN UT WOS:000392222200001 PM 28102329 ER PT J AU Wang, J Namburu, RR Dubey, M Dongare, AM AF Wang, Jin Namburu, Raju R. Dubey, Madan Dongare, Avinash M. TI Origins of Ripples in CVD-Grown Few-layered MoS2 Structures under Applied Strain at Atomic Scales SO SCIENTIFIC REPORTS LA English DT Article ID ULTRATHIN MOS2; THIN MOS2; GRAPHENE; TRANSISTORS; MONOLAYER; DYNAMICS; BILAYER; ENERGY AB The potential of the applicability of two-dimensional molybdenum disulfide (MoS2) structures, in various electronics, optoelectronics, and flexible devices requires a fundamental understanding of the effects of strain on the electronic, magnetic and optical properties. Particularly important is the recent capability to grow large flakes of few-layered structures using chemical vapor deposition (CVD) wherein the top layers are relatively smaller in size than the bottom layers, resulting in the presence of edges/steps across adjacent layers. This paper investigates the strain response of such suspended few-layered structures at the atomic scales using classic molecular dynamics (MD) simulations. MD simulations suggest that the suspended CVD-grown structures are able to relax the applied in-plane strain through the nucleation of ripples under both tensile and compressive loading conditions. The presence of terraced edges in these structures is the cause for the nucleation of ripples at the edges that grow towards the center of the structure under applied in-plane strains. The peak amplitudes of ripples observed are in excellent agreement with the experimental observations. The study provides critical insights into the mechanisms of strain relaxation of suspended few-layered MoS2 structures that determine the interplay between the mechanical response and the electronic properties of CVD-grown structures. C1 [Wang, Jin; Dongare, Avinash M.] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA. [Wang, Jin; Dongare, Avinash M.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Namburu, Raju R.] US Army Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. [Dubey, Madan] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Dongare, AM (reprint author), Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA.; Dongare, AM (reprint author), Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. EM dongare@uconn.edu FU Army Research Laboratory [W911NF-14-2-0059]; US Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-14-2-0059. The authors R. R. Namburu and M. Dubey acknowledge the support of the US Army Research Laboratory (ARL) Director's Strategic Initiative (DSI) program on interfaces in stacked 2D atomic layered materials. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. NR 45 TC 0 Z9 0 U1 24 U2 24 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JAN 19 PY 2017 VL 7 AR 40862 DI 10.1038/srep40862 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EI1FP UT WOS:000392222400001 PM 28102351 ER PT J AU Petrovas, C Ferrando-Martinez, S Gerner, MY Casazza, JP Pegu, A Deleage, C Cooper, A Hataye, J Andrews, S Ambrozak, D Estrada, PMD Boritz, E Paris, R Moysi, E Boswell, KL Ruiz-Mateos, E Vagios, I Leal, M Ablanedo-Terrazas, Y Rivero, A Gonzalez-Hernandez, LA McDermott, AB Moir, S Reyes-Teran, G Docobo, F Pantaleo, G Douek, DC Betts, MR Estes, JD Germain, RN Mascola, JR Koup, RA AF Petrovas, Constantinos Ferrando-Martinez, Sara Gerner, Michael Y. Casazza, Joseph P. Pegu, Amarendra Deleage, Claire Cooper, Arik Hataye, Jason Andrews, Sarah Ambrozak, David Del Rio Estrada, Perla M. Boritz, Eli Paris, Robert Moysi, Eirini Boswell, Kristin L. Ruiz-Mateos, Ezequiel Vagios, Ilias Leal, Manuel Ablanedo-Terrazas, Yuria Rivero, Amaranta Alicia Gonzalez-Hernandez, Luz McDermott, Adrian B. Moir, Susan Reyes-Teran, Gustavo Docobo, Fernando Pantaleo, Giuseppe Douek, Daniel C. Betts, Michael R. Estes, Jacob D. Germain, Ronald N. Mascola, John R. Koup, Richard A. TI Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies SO SCIENCE TRANSLATIONAL MEDICINE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; LYMPHOID-TISSUE; GERMINAL-CENTERS; VIRAL-INFECTION; RNA-SEQ; REPLICATION; EFFECTOR; LYMPHOCYTES; FOLLICLES; ACTIVATION AB Cytolytic CD8 T cells play a crucial role in the control and elimination of virus-infected cells and are a major focus of HIV cure efforts. However, it has been shown that HIV-specific CD8 T cells are infrequently found within germinal centers (GCs), a predominant site of active and latent HIV infection. We demonstrate that HIV infection induces marked changes in the phenotype, frequency, and localization of CD8 T cells within the lymph node (LN). Significantly increased frequencies of CD8 T cells in the B cell follicles and GCs were found in LNs from treated and untreated HIV-infected individuals. This profile was associated with persistent local immune activation but did not appear to be directly related to local viral replication. Follicular CD8 (fCD8) T cells, despite compromised cytokine polyfunctionality, showed good cytolytic potential characterized by high ex vivo expression of granzyme B and perforin. We used an anti-HIV/anti-CD3 bispecific antibody in a redirected killing assay and found that fCD8 T cells had better killing activity than did non-fCD8 T cells. Our results indicate that CD8 T cells with potent cytolytic activity are recruited to GCs during HIV infection and, if appropriately redirected to kill HIV-infected cells, could be an effective component of an HIV cure strategy. C1 [Petrovas, Constantinos; Ferrando-Martinez, Sara; Casazza, Joseph P.; Hataye, Jason; Ambrozak, David; Moysi, Eirini; Boswell, Kristin L.; Koup, Richard A.] NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA. [Gerner, Michael Y.; Germain, Ronald N.] NIAID, Lab Syst Biol, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Pegu, Amarendra; Cooper, Arik; Mascola, John R.] NIAID, Virol Lab, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Deleage, Claire; Estes, Jacob D.] Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Leidos Biomed Res Inc, BG 535,POB B, Frederick, MD 21702 USA. [Andrews, Sarah; McDermott, Adrian B.] NIAID, Immunol Core Sect, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Del Rio Estrada, Perla M.; Ablanedo-Terrazas, Yuria; Rivero, Amaranta; Alicia Gonzalez-Hernandez, Luz; Reyes-Teran, Gustavo] Inst Nacl Enfermedades Resp, Dept Invest Enfermedades Infecciosas, Mexico City, DF, Mexico. [Boritz, Eli; Douek, Daniel C.] NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Paris, Robert] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Ruiz-Mateos, Ezequiel; Leal, Manuel; Docobo, Fernando] Univ Seville, Lab Immunovirol, Hosp Univ Virgen Rocio, Inst Biomed Sevilla,CSIC, Seville 41013, Spain. [Vagios, Ilias] Venizeleio Hosp, Dept Histopathol, Iraklion, Crete, Greece. [Moir, Susan] NIAID, Immunoregulat Lab, Bldg 10, Bethesda, MD 20892 USA. [Pantaleo, Giuseppe] Univ Lausanne, Univ Lausanne Hosp, Dept Med, Serv Immunol & Allergy,Serv Infect Dis, CH-1011 Lausanne, Switzerland. [Pantaleo, Giuseppe] Univ Lausanne, Univ Lausanne Hosp, Swiss Vaccine Res Inst, CH-1011 Lausanne, Switzerland. [Betts, Michael R.] Univ Penn, Dept Microbiol, Ctr AIDS Res, Perelman Sch Med, Philadelphia, PA 19104 USA. [Betts, Michael R.] Univ Penn, Inst Immunol, Perelman Sch Med, Philadelphia, PA 19104 USA. [Gerner, Michael Y.] Univ Washington, Dept Immunol, Seattle, WA 98109 USA. RP Petrovas, C (reprint author), NIAID, Immunol Lab, Vaccine Res Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA. EM petrovasc@mail.nih.gov FU VRC, NIAID, NIH; Bill and Melinda Gates Foundation [OPP1032325]; National Cancer Institute, NIH [HHSN261200800001E]; Redes Telematicas de Investigacion Cooperativa en Salud (RETICS; Red de SIDA) [RD12/0017/0029]; Fondo de Investigacion Sanitaria [PI12/02283, PI13/01912, CP08/00172, CPII14/00025] FX This research was supported by the Intramural Research Program of the VRC, NIAID, NIH, and CAVD grant (#OPP1032325) from the Bill and Melinda Gates Foundation (R.A.K.). This project was funded in part with federal funds from the National Cancer Institute, NIH, under contract no. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Part of the research was also supported by Redes Telematicas de Investigacion Cooperativa en Salud (RETICS; Red de SIDA, RD12/0017/0029) and Fondo de Investigacion Sanitaria (grants PI12/02283 and PI13/01912). E.R.-M. was supported by Fondo de Investigacion Sanitaria (grants CP08/00172 and CPII14/00025). NR 59 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 1946-6234 EI 1946-6242 J9 SCI TRANSL MED JI Sci. Transl. Med. PD JAN 18 PY 2017 VL 9 IS 373 AR eaag2285 DI 10.1126/scitranslmed.aag2285 PG 14 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA EL2JX UT WOS:000394447000004 ER PT J AU Lazarus, N Bedair, SS Kierzewski, IM AF Lazarus, Nathan Bedair, Sarah S. Kierzewski, Iain M. TI Ultrafine Pitch Stencil Printing of Liquid Metal Alloys SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE liquid metal; stencil printing; stretchable electronics; electroplated stencil; galinstan ID STRETCHABLE ELECTRONICS; SOLDER PASTE; FINE; TEMPERATURE; DENSITY; CORE AB With high conductivity and stretchable for large cross-sections, liquid metals such as galinstan are promising for creating stretchable devices and interconnects. Creating high resolution features in parallel is challenging, with most techniques limited to a hundred micrometers or more. In this work, multilevel electroplated stencils are investigated for printing liquid metals, with galinstan features as small as ten micrometers printed on soft elastomers, a factor of 10 reduction over past liquid metal stencil printing. Capacitors and resistive strain sensors are also demonstrated, showing the potential for creating stretchable conductors and devices. C1 [Lazarus, Nathan; Bedair, Sarah S.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Kierzewski, Iain M.] Gen Tech Serv Inc, Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Lazarus, N (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nathan.lazarus2.civ@mail.mil NR 31 TC 0 Z9 0 U1 12 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD JAN 18 PY 2017 VL 9 IS 2 BP 1178 EP 1182 DI 10.1021/acsami.6b13088 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA EI4IZ UT WOS:000392458300004 PM 28058840 ER PT J AU Plonka, AM Wang, Q Gordon, WO Balboa, A Troya, D Guo, WW Sharp, CH Senanayake, SD Morris, JR Hill, CL Frenkel, AI AF Plonka, Anna M. Wang, Qi Gordon, Wesley O. Balboa, Alex Troya, Diego Guo, Weiwei Sharp, Conor H. Senanayake, Sanjaya D. Morris, John R. Hill, Craig L. Frenkel, Anatoly I. TI In Situ Probes of Capture and Decomposition of Chemical Warfare Agent Simulants by Zr-Based Metal Organic Frameworks SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID DESTRUCTION; HYDROLYSIS; STORAGE; DECONTAMINATION; ADSORPTION; HYDROGEN; UIO-66; WATER; VX AB Zr-based metal organic frameworks (MOFs) have been recently shown to be among the fastest catalysts of nerve-agent. hydrolysis in solution. We report a detailed study of the adsorption and decomposition of a nerve-agent simulant, dimethyl methylphosphonate (DMMP), on UiO-66, UiO-67, MOF-808, and NU-1000 using synchrotron-based X-ray powder diffraction, X-ray absorption, and infrared spectroscopy, which reveals key aspects of the reaction mechanism. The diffraction measurements indicate that all four MOFs adsorb DMMP (introduced at atmospheric pressures through a flow of helium or air) within the pore space. In addition, the combinatitin of X-ray absorption and infrared spectra suggests direct coordination of DMMP to the Zr-6 cores of all MOFs, which ultimately leads to decomposition to phosphonate products. These experimental probes into the mechanism of adsorption and decomposition of chemical warfare agent simulants on Zr-based MOFs open new opportunities in rational design of new and superior decontamination materials. C1 [Plonka, Anna M.; Wang, Qi; Frenkel, Anatoly I.] SUNY Stony Brook, Dept Mat Sci & Chem Engn, Stony Brook, NY 11794 USA. [Gordon, Wesley O.; Balboa, Alex] US Army, Edgewood Chem Biol Ctr APG, Aberdeen Proving Ground, MD 21010 USA. [Troya, Diego; Sharp, Conor H.; Morris, John R.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. [Guo, Weiwei; Hill, Craig L.] Emory Univ, Dept Chem, 1515 Pierce Dr, Atlanta, GA 30322 USA. [Senanayake, Sanjaya D.] Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA. EM anatoly.frenkel@stonybrook.edu RI Frenkel, Anatoly/D-3311-2011 OI Frenkel, Anatoly/0000-0002-5451-1207 FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-15-2-0107]; Defense Threat Reduction Agency [BB11PHM156]; U.S. Department of Energy [DE-AC02-06CH11357, DE-AC02-76SF00515, DE-SC0012704, DE-SC0012335] FX This work is supported by the U.S. Army Research Laboratory and the U.S. Army Research Office under Grant No. W911NF-15-2-0107. The authors thank the Defense Threat Reduction Agency for support under program BB11PHM156. Use of Advanced Photon Source, Stanford Synchrotron Radiation Lightsource, and National Synchrotron Light Source II was supported by the U.S. Department of Energy under Contract Nos. DE-AC02-06CH11357, DE-AC02-76SF00515, and DE-SC0012704, respectively. In situ operations at the BL2-2 beamline at SLAC were made possible by the U.S. Department of Energy Grant No. DE-SC0012335. A.I.F. and Q.W. thank Prof. C. Lamberti for valuable discussions. The authors are grateful to Prof. J. T. Hupp and Prof. O. K. Farha for generously providing the sample of NU-1000. NR 34 TC 0 Z9 0 U1 67 U2 67 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD JAN 18 PY 2017 VL 139 IS 2 BP 599 EP 602 DI 10.1021/jacs.6b11373 PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA EI4JH UT WOS:000392459300009 PM 28038315 ER PT J AU Cheng, MX Ling, Y Sadler, BM AF Cheng, Maggie X. Ling, Yi Sadler, Brian M. TI Network connectivity assessment and improvement through relay node deployment SO THEORETICAL COMPUTER SCIENCE LA English DT Article DE Network connectivity; Linear programming; Optimization ID WIRELESS SENSOR NETWORKS; ROBOT TEAMS; PLACEMENT; REPAIR AB In wireless ad hoc networks, maintaining network connectivity is very important as high level network functions all depend on it. However, how to measure network connectivity remains a fundamental challenge. For example, a network can have good overall k-connectivity and yet still have a communication bottleneck. In this paper, we address how to locate bottlenecks and relieve them. A new connectivity measure based on the Cheeger's Constant is used for bottleneck discovery, and a partition algorithm that divides the network at the bottleneck is developed. After the network is partitioned, we consider deploying a relay node to increase the conductance of the network across the partition. The relay node deployment problem is formulated as an integer linear program to maximize the number of connections between the two sides of the cut, and then a convex optimization algorithm is used to find the precise location of the relay node, which is within the convex hull defined by the radio transmission ranges of all the nodes that can connect to the relay node. We show that the relay node significantly relieves the bottleneck and improves network connectivity, which is manifested by several network connectivity metrics. The partition and relay node deployment algorithms are then extended to the case where multiple relay nodes are available. Multiway partition and multiple relay node deployment algorithms are presented. Simulation results show this approach effectively enhances network connectivity with a small number of relay nodes. (C) 2016 Elsevier B.V. All rights reserved. C1 [Cheng, Maggie X.] New Jersey Inst Technol, Newark, NJ 07102 USA. [Ling, Yi] Missouri Univ Sci & Technol, Rolla, MO 65401 USA. [Sadler, Brian M.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Cheng, MX (reprint author), New Jersey Inst Technol, Newark, NJ 07102 USA. EM maggie.cheng@njit.edu; lyz29@mst.edu; brian.m.sadler6.civ@mail.mil FU National Science Foundation [ECCS-1307458, CNS-1537538, CNS-1545063, CMMI-1551448] FX Maggie Cheng and Yi Ling are supported by National Science Foundation (ECCS-1307458, CNS-1537538, CNS-1545063, and CMMI-1551448). NR 23 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3975 EI 1879-2294 J9 THEOR COMPUT SCI JI Theor. Comput. Sci. PD JAN 17 PY 2017 VL 660 BP 86 EP 101 DI 10.1016/j.tcs.2016.11.029 PG 16 WC Computer Science, Theory & Methods SC Computer Science GA EI8VL UT WOS:000392786200006 ER PT J AU Izvekov, S AF Izvekov, Sergei TI Mori-Zwanzig theory for dissipative forces in coarse-grained dynamics in the Markov limit SO PHYSICAL REVIEW E LA English DT Article ID PARTICLE DYNAMICS; MOLECULAR-DYNAMICS; MESOSCOPIC SIMULATION; BIOMOLECULAR SYSTEMS; OPTIMAL PREDICTION; LANGEVIN DYNAMICS; BROWNIAN-MOTION; SOFT MATTER; MEMORY; SURFACTANTS AB We derive alternative Markov approximations for the projected (stochastic) force and memory function in the coarse-grained (CG) generalized Langevin equation, which describes the time evolution of the center-of-mass coordinates of clusters of particles in the microscopic ensemble. This is done with the aid of the Mori-Zwanzig projection operator method based on the recently introduced projection operator [S. Izvekov, J. Chem. Phys. 138, 134106 (2013)]. The derivation exploits the "generalized additive fluctuating force" representation to which the projected force reduces in the adopted projection operator formalism. For the projected force, we present a first-order time expansion which correctly extends the static fluctuating force ansatz with the terms necessary to maintain the required orthogonality of the projected dynamics in the Markov limit to the space of CG phase variables. The approximant of the memory function correctly accounts for the momentum dependence in the lowest (second) order and indicates that such a dependence may be important in the CG dynamics approaching the Markov limit. In the case of CG dynamics with a weak dependence of the memory effects on the particle momenta, the expression for the memory function presented in this work is applicable to non-Markov systems. The approximations are formulated in a propagator-free form allowing their efficient evaluation from the microscopic data sampled by standard molecular dynamics simulations. A numerical application is presented for a molecular liquid (nitromethane). With our formalism we do not observe the "plateau-value problem" if the friction tensors for dissipative particle dynamics (DPD) are computed using the Green-Kubo relation. Our formalism provides a consistent bottom-up route for hierarchical parametrization of DPD models from atomistic simulations. C1 [Izvekov, Sergei] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. RP Izvekov, S (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. EM sergiy.izvyekov.civ@mail.mil NR 71 TC 0 Z9 0 U1 5 U2 5 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0045 EI 2470-0053 J9 PHYS REV E JI Phys. Rev. E PD JAN 17 PY 2017 VL 95 IS 1 AR 013303 DI 10.1103/PhysRevE.95.013303 PG 16 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA EI1ZG UT WOS:000392284900024 PM 28208451 ER PT J AU Hruby, A Bulathsinhala, L McKinnon, CJ Hill, OT Montain, SJ Young, AJ Smith, TJ AF Hruby, Adela Bulathsinhala, Lakmini McKinnon, Craig J. Hill, Owen T. Montain, Scott J. Young, Andrew J. Smith, Tracey J. TI Body Mass Index at Accession and Incident Cardiometabolic Risk Factors in US Army Soldiers, 2001-2011 SO PLOS ONE LA English DT Article ID YOUNG-ADULTS CARDIA; 20-YEAR FOLLOW-UP; CARDIORESPIRATORY FITNESS; CARDIOVASCULAR-DISEASE; PHYSICAL-FITNESS; HEALTHY OBESE; OVERWEIGHT; ASSOCIATION; PREVALENCE; DEPLOYMENT AB Individuals entering US Army service are generally young and healthy, but many are overweight, which may impact cardiometabolic risk despite physical activity and fitness requirements. This analysis examines the association between Soldiers' BMI at accession and incident cardiometabolic risk factors (CRF) using longitudinal data from 731,014 Soldiers (17.0% female; age: 21.6 [3.9] years; BMI: 24.7 [3.8] kg/m2) who were assessed at Army accession, 2001-2011. CRF were defined as incident diagnoses through 2011, by ICD-9 code, of metabolic syndrome, glucose/insulin disorder, hypertension, dyslipidemia, or overweight/obesity (in those not initially overweight/obese). Multivariable-adjusted proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) between BMI categories at accession and CRF. Initially underweight (BMI<18.5 kg/m(2)) were 2.4% of Soldiers, 53.5% were normal weight (18.5-<25), 34.2% were overweight (25 -<30), and 10.0% were obese (>= 30). Mean age range at CRF diagnosis was 24-29 years old, with generally low CRF incidence: 228 with metabolic syndrome, 3,880 with a glucose/insulin disorder, 26,373 with hypertension, and 13,404 with dyslipidemia. Of the Soldiers who were not overweight or obese at accession, 5,361 were eventually diagnosed as overweight or obese. Relative to Soldiers who were normal weight at accession, those who were overweight or obese, respectively, had significantly higher risk of developing each CRF after multivariable adjustment (HR [95% CI]: metabolic syndrome: 4.13 [2.87-5.94], 13.36 [9.00-19.83]; glucose/insulin disorder: 1.39 [1.30-1.50], 2.76 [2.52-3.04]; hypertension: 1.85 [1.80-1.90], 3.31 [3.20-3.42]; dyslipidemia: 1.81 [1.75-1.89], 3.19 [3.04-3.35]). Risk of hypertension, dyslipidemia, and overweight/obesity in initially underweight Soldiers was 40%, 31%, and 79% lower, respectively, versus normal-weight Soldiers. BMI in early adulthood has important implications for cardiometabolic health, even within young, physically active populations. C1 [Hruby, Adela; Montain, Scott J.; Young, Andrew J.; Smith, Tracey J.] US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Hruby, Adela] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Epidemiol Program, Boston, MA 02111 USA. [Bulathsinhala, Lakmini; McKinnon, Craig J.; Hill, Owen T.] US Army, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Bulathsinhala, Lakmini; Hill, Owen T.] US Army, Med Dept Ctr & Sch, Hlth Readiness Ctr Excellence, Ft Sam Houston, TX USA. RP Smith, TJ (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. EM tracey.smith10.civ@mail.mil FU United States Army Medical Research and Materiel Command FX This work was funded in part by the United States Army Medical Research and Materiel Command. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 40 TC 0 Z9 0 U1 3 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 17 PY 2017 VL 12 IS 1 AR e0170144 DI 10.1371/journal.pone.0170144 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EI3EK UT WOS:000392372300061 PM 28095509 ER PT J AU Lee, DW Khavrutskii, IV Wallqvist, A Bavari, S Cooper, CL Chaudhury, S AF Lee, Donald W. Khavrutskii, Ilja V. Wallqvist, Anders Bavari, Sina Cooper, Christopher L. Chaudhury, Sidhartha TI BRILIA: Integrated Tool for High-Throughput Annotation and Lineage tree Assembly of B-Cell Repertoires SO FRONTIERS IN IMMUNOLOGY LA English DT Article DE B-cell receptor (BCR); repertoire; annotation; lineage; VDJ; somatic hypermutation (SHM) ID INTERNATIONAL IMMUNOGENETICS DATABASE; TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE; SOMATIC HYPERMUTATION; V(D)J RECOMBINATION; SEQUENCE-ANALYSIS; GERMINAL-CENTERS; VARIABLE REGION; IMMUNOGLOBULIN REPERTOIRE; INFORMATION SYSTEM(R); AFFINITY MATURATION AB The somatic diversity of antigen-recognizing B-cell receptors (BCRs) arises from Variable (V), Diversity (D), and Joining (J) (VDJ) recombination and somatic hypermutation (SHM) during B-cell development and affinity maturation. The VDJ junction of the BCR heavy chain forms the highly variable complementarity determining region 3 (CDR3), which plays a critical role in antigen specificity and binding affinity. Tracking the selection and mutation of the CDR3 can be useful in characterizing humoral responses to infection and vaccination. Although tens to hundreds of thousands of unique BCR genes within an expressed B-cell repertoire can now be resolved with high-throughput sequencing, tracking SHMs is still challenging because existing annotation methods are often limited by poor annotation coverage, inconsistent SHM identification across the VDJ junction, or lack of B-cell lineage data. Here, we present B-cell repertoire inductive lineage and immunosequence annotator (BRILIA), an algorithm that leverages repertoire-wide sequencing data to globally improve the VDJ annotation coverage, lineage tree assembly, and SHM identification. On benchmark tests against simulated human and mouse BCR repertoires, BRILIA correctly annotated germline and clonally expanded sequences with 94 and 70% accuracy, respectively, and it has a 90% SHM-positive prediction rate in the CDR3 of heavily mutated sequences; these are substantial improvements over existing methods. We used BRILIA to process BCR sequences obtained from splenic germinal center B cells extracted from C57BL/6 mice. BRILIA returned robust B-cell lineage trees and yielded SHM patterns that are consistent across the VDJ junction and agree with known biological mechanisms of SHM. By contrast, existing BCR annotation tools, which do not account for repertoire-wide clonal relationships, systematically underestimated both the size of clonally related B-cell clusters and yielded inconsistent SHM frequencies. We demonstrate BRILIA's utility in B-cell repertoire studies related to VDJ gene usage, mechanisms for adenosine mutations, and SHM hot spot motifs. Furthermore, we show that the complete gene usage annotation and SHM identification across the entire CDR3 are essential for studying the B-cell affinity maturation process through immunosequencing methods. C1 [Lee, Donald W.; Khavrutskii, Ilja V.; Wallqvist, Anders; Chaudhury, Sidhartha] US Army Med Res & Mat Command, Biotechnol HPC Software Applicat Inst BHSAI, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Bavari, Sina; Cooper, Christopher L.] US Army Med Res Inst Infect Dis, Mol & Translat Sci, Frederick, MD USA. RP Chaudhury, S (reprint author), US Army Med Res & Mat Command, Biotechnol HPC Software Applicat Inst BHSAI, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM sidhartha.chaudhury.civ@mail.mil FU Military Infectious Diseases Research Program of the United States (US) Army Medical Research and Materiel Command; US Department of Defense (DoD) High-Performance Computing Modernization Program; US Department of Defense's Defense Threat Reduction Agency (DTRA) FX Support for this research was provided by the Military Infectious Diseases Research Program of the United States (US) Army Medical Research and Materiel Command and the US Department of Defense (DoD) High-Performance Computing Modernization Program. This research was in part funded by grants provided to USAMRIID by the US Department of Defense's Defense Threat Reduction Agency (DTRA). The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Army or the US DoD. This paper has been approved for public release with unlimited distribution. NR 99 TC 0 Z9 0 U1 3 U2 3 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-3224 J9 FRONT IMMUNOL JI Front. Immunol. PD JAN 17 PY 2017 VL 7 AR UNSP 681 DI 10.3389/fimmu.2016.00681 PG 18 WC Immunology SC Immunology GA EH8MV UT WOS:000392027100001 ER PT J AU Sereti, I Krebs, SJ Phanuphak, N Fletcher, JL Slike, B Pinyakorn, S O'Connell, RJ Rupert, A Chomont, N Valcour, V Kim, JH Robb, ML Michael, NL Douek, DC Ananworanich, J Utay, NS AF Sereti, Irini Krebs, Shelly J. Phanuphak, Nittaya Fletcher, James L. Slike, Bonnie Pinyakorn, Suteeraporn O'Connell, Robert J. Rupert, Adam Chomont, Nicolas Valcour, Victor Kim, Jerome H. Robb, Merlin L. Michael, Nelson L. Douek, Daniel C. Ananworanich, Jintanat Utay, Netanya S. CA RV254 SEARCH 010 Protocol Teams RV304 SEARCH 013 Protocol Teams SEARCH 011 Protocol Teams TI Persistent, Albeit Reduced, Chronic Inflammation in Persons Starting Antiretroviral Therapy in Acute HIV Infection SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE acute HIV infection; antiretroviral therapy; inflammation; monocyte activation; sIL-6R ID MONOCYTE ACTIVATION; PREDICT MORTALITY; IMMUNE ACTIVATION; D-DIMER; AIDS; INTERLEUKIN-6; COAGULATION; DISEASE; MARKERS; RISK AB Background. Serious non-AIDS events cause substantial disease and death despite human immunodeficiency virus (HIV) suppression with antiretroviral therapy (ART). Biomarkers of inflammation, coagulation cascade activation, and fibrosis predict these end-organ events. We aimed to determine whether ART initiation during acute HIV infection would attenuate changes in these biomarker levels. Methods. Plasma samples were obtained from participants starting ART during acute or chronic HIV infection and from HIV-uninfected participants from Bangkok, Thailand. Biomarkers of inflammation (C-reactive protein [CRP], interleukin 6, soluble interleukin 6 receptor [sIL-6R], soluble gp130, tumor necrosis factor [TNF]), enterocyte turnover (intestinal fatty acid binding protein [I-FABP]), lipopolysaccharide-induced monocyte activation (soluble CD14 [sCD14]), coagulation cascade activation [D-dimer], and fibrosis (hyaluronic acid [HA]) were measured at baseline and through 96 weeks of ART. Results. CRP, TNF, sIL-6R, I-FABP, sCD14, D-dimer, and HA levels were elevated in acute HIV infection. Early ART was associated with increased I-FABP levels but normalization of TNF, sIL-6R, and D-dimer levels. CRP, sCD14, and HA levels decreased during ART but remained elevated compared with HIV-uninfected participants. Higher sCD14, CRP, and D-dimer levels were associated with higher peripheral blood mononuclear cell and gut integrated HIV DNA levels. Decreases in sCD14 and CRP levels were correlated with increases in CD4 T-cell counts. Conclusions. ART initiated in early acute HIV infection was associated with normalization of the coagulation cascade and several systemic inflammatory biomarkers, but the acute-phase response, enterocyte turnover, monocyte activation, and fibrosis biomarkers remained elevated. Additional interventions to attenuate inflammation may be needed to optimize clinical outcomes in persons with HIV infection. C1 [Sereti, Irini] NIAID, Immunoregulat Lab, NIH, Bldg 10, Bethesda, MD 20892 USA. [Douek, Daniel C.] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA. [Krebs, Shelly J.; Slike, Bonnie; Pinyakorn, Suteeraporn; O'Connell, Robert J.; Kim, Jerome H.; Robb, Merlin L.; Michael, Nelson L.; Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Krebs, Shelly J.; Slike, Bonnie; Pinyakorn, Suteeraporn; O'Connell, Robert J.; Kim, Jerome H.; Robb, Merlin L.; Michael, Nelson L.; Ananworanich, Jintanat] US Mil, HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Rupert, Adam] Frederick Natl Lab Canc Res, AIDS Monitoring Lab, Leidos Biomed Res, Frederick, MD USA. [Valcour, Victor] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, Sandler Neurosci Ctr, San Francisco, CA 94143 USA. [Utay, Netanya S.] Univ Texas Med Branch, Div Infect Dis, Dept Internal Med, 301 Univ Blvd,Rte 0435, Galveston, TX 77555 USA. [Phanuphak, Nittaya; Fletcher, James L.; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [O'Connell, Robert J.] US Army Med Component, Dept Retrovirol, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Chomont, Nicolas] Univ Montreal, CHUM, Ctr Rech, Montreal, PQ H3C 3J7, Canada. [Chomont, Nicolas] Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ H3C 3J7, Canada. [Kim, Jerome H.] SNU Res Pk, Int Vaccine Inst, Seoul, South Korea. RP Utay, NS (reprint author), Univ Texas Med Branch, Div Infect Dis, Dept Internal Med, 301 Univ Blvd,Rte 0435, Galveston, TX 77555 USA. EM neutay@utmb.edu FU Intramural Research Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases; Henry M. Jackson Foundation for the Advancement of Military Medicine [W81XWH-11-2-0174]; US Department of Defense [W81XWH-11-2-0174]; National Institutes of Health [R01MH095613, R01NS061696]; Government Pharmaceutical Organization (GPO), Thailand; Gilead; Merck; ViiV Healthcare FX This work was supported by the Intramural Research Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases; by a cooperative agreement (W81XWH-11-2-0174) between The Henry M. Jackson Foundation for the Advancement of Military Medicine and the US Department of Defense; and by the National Institutes of Health (grants R01MH095613 and R01NS061696 to SEARCH 010 and SEARCH 011, respectively). The Government Pharmaceutical Organization (GPO), Thailand, Gilead, Merck and ViiV Healthcare provided support for antiretroviral medications. NR 33 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 15 PY 2017 VL 64 IS 2 BP 124 EP 131 DI 10.1093/cid/ciw683 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA EP1GB UT WOS:000397132300009 PM 27737952 ER PT J AU Ivashchenko, VI Dub, SN Scrynskyy, PL Kozak, AO Gorb, L Hill, F Leszczynski, J AF Ivashchenko, V. I. Dub, S. N. Scrynskyy, P. L. Kozak, A. O. Gorb, Leonid Hill, Frances Leszczynski, Jerzy TI Characterization of Al-Mg-B-C films based on experimental and first-principles investigations SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE DC magnetron sputtering; AIMgB(14); B4C; Chemical bonding; Nanoindentation; First-principles calculations ID SUBOXIDE THIN-FILMS; ULTRA-HARD ALMGB14; MECHANICAL-PROPERTIES; WEAR MECHANISMS; MICROSTRUCTURE; DEPOSITION; ALUMINUM; FRICTION; SURFACE; STATE AB Al-Mg-B and Al-Mg-B-C films were deposited by DC magnetron sputtering from the AlMgB14 and B4C targets on silicon substrates at different discharge power densities at both the targets. The deposited films were characterized by atomic force microscopy, X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, nanoindentation, scratch and pin-on-disk testing. All the deposited films were found to be X-ray amorphous. The film roughness, nanohardness and elastic modulus increase with the discharge power densities at both targets. An introduction of carbon is accompanied by the formation of the strong C-B-4 units that strengthen Al-Mg-B-C films. The films exhibit a coefficient of friction in the range of 0.09-020. First-principles calculations show that the amorphous AIMgB(14)-based materials consist of the fragments of boron icosahedra, for which reason they possess the hardness that is lower than the hardness of the crystalline counterparts. Based on experimental and theoretical results, it is assumed that the observed strength enhancement can be assigned to an improvement of the B-B icosahedron-like network and film densification. (C) 2016 Elsevier B.V. All rights reserved. C1 [Ivashchenko, V. I.; Scrynskyy, P. L.; Kozak, A. O.] NAS Ukraine, Frantsevych Inst Problems Mat Sci, 3 Kizhyzhanovsky Str, UA-03142 Kiev, Ukraine. [Dub, S. N.] NAS Ukraine, Bakul Inst Superhard Mat, 2 Avtozavodska Str, UA-04074 Kiev, Ukraine. [Gorb, Leonid; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS 39180 USA. [Hill, Frances] US Army, Erdc, Vicksburg, MS 39180 USA. RP Ivashchenko, VI (reprint author), NAS Ukraine, Frantsevych Inst Problems Mat Sci, 3 Kizhyzhanovsky Str, UA-03142 Kiev, Ukraine. EM ivash@materials.kiev.ua FU STCU [5964] FX This work was supported by the STCU Contract No. 5964. We would like to thank Stan Veprek for his comments on the mechanisms of the strength enhancement in BAM-based films. We are grateful to Dr. O. Lytvyn for AFM measurements, Dr. O.K. Sinelnichenko for XPS measurements and PhD V.F. Brytun for TEM investigations. The authors are grateful to the directorate of the Summery Institute at Jackson State University for the possibility to perform large-scale calculations. NR 40 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD JAN 15 PY 2017 VL 309 BP 164 EP 171 DI 10.1016/j.surfcoat.2016.07.044 PG 8 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA EN7LN UT WOS:000396184400020 ER PT J AU Kopczynski, SE Kelley, SE Lowell, TV Evenson, EB Applegate, PJ AF Kopczynski, Sarah E. Kelley, Samuel E. Lowell, Thomas V. Evenson, Edward B. Applegate, Patrick J. TI Latest Pleistocene advance and collapse of the Matanuska - Knik glacier system, Anchorage Lowland, southern Alaska SO QUATERNARY SCIENCE REVIEWS LA English DT Article DE Anchorage Lowland; Deglaciation; Elmendorf Moraine; Matanuska Glacier; Knik Glacier; Termination ID CORDILLERAN ICE-SHEET; ABRUPT CLIMATE-CHANGE; CENTRAL BROOKS RANGE; HEINRICH STADIAL 1; RADIOCARBON CHRONOLOGY; AHKLUN MOUNTAINS; LAST GLACIATION; ARCTIC ALASKA; UNITED-STATES; BE-10 AGES AB At the end of the last ice age, glacier systems worldwide underwent dramatic retreat. Here, we document the advance and retreat of a glacier system with adjacent marine-and land-based components during the latter part of the Termination. We utilize three lines of evidence: lithologic provenance, geomorphic mapping, and radiocarbon ages derived from lake cores to reconstruct glacier extent and timing of advance and retreat within our study area centered at N 61.50 degrees, W 149.50 degrees, just north of Anchorage, Alaska. Two glaciers, sourced in the Talkeetna and Chugach Mountains, flowed down the Matanuska and Knik Valleys forming a coalesced lobe that advanced onto the Anchorage Lowlands and terminated at Elmendorf Moraine. We use the presence of lithologies unique to the Matanuska catchment in glacial drift to delineate the paleoflow lines and to estimate the suture line of the two glacier systems. The eastern side of the lobe, attributed to ice flow from the Knik Valley, was in contact with elevated marine waters within the Knik Arm fjord, and thus retreat was likely dominated by calving. Geomorphic evidence suggests the western side of the lobe, attributed to ice flow from Matanuska Valley, retreated due to stagnation. We constrain retreat of the combined Matanuska and Knik lobe with thirteen new radiocarbon ages, in addition to previously published radiocarbon ages, and with geomorphic evidence suggesting the retreat occurred in two phases. Retreat from the Elmendorf Moraine began between 16.8 and 16.4 ka BP. A second, faster retreat phase occurred later and was completed by 13.7 ka BP. With the 140 km of total retreat occurring over similar to 3000 years or less. This pattern of glacial advance and retreats agrees well with the deglacial histories from the southern sectors of the Cordilleran Ice Sheet, as well as many other alpine glacier systems in the western U.S. and northern Alaska. This consistent behavior of glacier systems may indicate that climate oscillated over western North America early in deglaciation before it was recorded in other proxies such as ice cores. Furthermore, the period in which we note mountain glacier collapse in northwestern North America is synchronous with the worldwide glacial termination raising questions about intrahemispheric linkages. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Kopczynski, Sarah E.] Cold Reg Res & Engn Lab, Anchorage, AK 99507 USA. [Kelley, Samuel E.] Univ Waterloo, Dept Earth & Environm Sci, Waterloo, ON N2L 3G1, Canada. [Lowell, Thomas V.] Univ Cincinnati, Geol, Cincinnati, OH 45221 USA. [Evenson, Edward B.] Lehigh Univ, Dept Earth Sci, Bethlehem, PA 18015 USA. [Applegate, Patrick J.] Penn State Univ, Earth & Environm Syst Inst, 503 Deike Bldg, University Pk, PA 16802 USA. RP Kelley, SE (reprint author), Univ Waterloo, Dept Earth & Environm Sci, Waterloo, ON N2L 3G1, Canada. EM Samuel.Kelley@uwaterloo.ca FU U.S. Army Corps of Engineers; Geological Society of America; Sigma Xi; United States Geological Survey; Lehigh University; University of Cincinnati Department of Geology FX Funding was generously provided by the U.S. Army Corps of Engineers, Geological Society of America, Sigma Xi, United States Geological Survey, Lehigh University, and the University of Cincinnati Department of Geology. Field support and advice was generously provided by Mr. William Stevenson of Alaska Outfitters. Mr. Alfred Sturmann assisted with the reduction of the provenance data. Dr. Richard Reger provided field guidance and substantial feedback during the design of this project as well as during the drafting of this manuscript. Dr. Brent Ward and an anonymous reviewer are thanked for their comments, which improved this manuscipt. NR 76 TC 0 Z9 0 U1 2 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0277-3791 J9 QUATERNARY SCI REV JI Quat. Sci. Rev. PD JAN 15 PY 2017 VL 156 BP 121 EP 134 DI 10.1016/j.quascirev.2016.11.026 PG 14 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA EK0OZ UT WOS:000393627600010 ER PT J AU Johnson, KL Trim, MW Francis, DK Whittington, WR Miller, JA Bennett, CE Horstemeyer, MF AF Johnson, K. L. Trim, M. W. Francis, D. K. Whittington, W. R. Miller, J. A. Bennett, C. E. Horstemeyer, M. F. TI Moisture, anisotropy, stress state, and strain rate effects on bighorn sheep horn keratin mechanical properties SO ACTA BIOMATERIALIA LA English DT Article DE Sheep horn; Keratin; Stress state dependence; Strain rate dependence; Mechanical properties; Structure-property relations ID BIOLOGICAL-MATERIALS; HYDRATION; COMPOSITES; TENSILE; BOVIDS; DESIGN AB This paper investigates the effects of moisture, anisotropy, stress state, and strain rate on the mechanical properties of the bighorn sheep (Ovis Canadensis) horn keratin. The horns consist of fibrous keratin tubules extending along the length of the horn and are contained within an amorphous keratin matrix. Samples were tested in the rehydrated (35 wt% water) and ambient dry (10 wt% water) conditions along the longitudinal and radial directions under tension and compression. Increased moisture content was found to increase ductility and decrease strength, as well as alter the stress state dependent nature of the material. The horn keratin demonstrates a significant strain rate dependence in both tension and compression, and also showed increased energy absorption in the hydrated condition at high strain rates when compared to quasi-static data, with increases of 114% in tension and 192% in compression. Compressive failure occurred by lamellar buckling in the longitudinal orientation followed by shear delamination. Tensile failure in the longitudinal orientation occurred by lamellar delamination combined with tubule pullout and fracture. The structure-property relationships quantified here for bighorn sheep horn keratin can be used to help validate finite element simulations of ram's impacting each other as well as being useful for other analysis regarding horn keratin on other animals. Statement of Significance The horn of the bighorn sheep is an anisotropic composite composed of keratin that is highly sensitive to moisture content. Keratin is also found in many other animals in the form of hooves, claws, beaks, and feathers. Only one previous study contains high rate experimental data, which was performed in the dry condition and only in compression. Considering the bighorn sheep horns' protective role in high speed impacts along with the moisture and strain rate sensitivity, more high strain rate data is needed to fully characterize and model the material. This study provides high strain rate results demonstrating the effects of moisture, anisotropy, and stress state. As a result, the comprehensive data allows modeling efforts to be greatly improved. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Johnson, K. L.; Horstemeyer, M. F.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. [Johnson, K. L.; Francis, D. K.; Whittington, W. R.; Miller, J. A.; Bennett, C. E.; Horstemeyer, M. F.] CAVS, 200 Res Blvd, Mississippi State, MS 39762 USA. [Trim, M. W.] US Army Engn Res & Dev Ctr, Geotech & Struct Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. [Bennett, C. E.] Mississippi State Univ, Dept Agr & Biol Engn, Mississippi State, MS 39762 USA. RP Johnson, KL (reprint author), Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. EM kljohnsonmsu@gmail.com OI Horstemeyer, Mark/0000-0003-4230-0063 FU Center for Advanced Vehicular Systems (Center for Advanced Vehicular Systems, Mississippi State University) at Mississippi State University; Department of Energy Southern Regional Center for Lightweight Innovative Design (SRCLID) [DE-EE0002323]; agency of the United States Government FX Support from the Center for Advanced Vehicular Systems (Center for Advanced Vehicular Systems, Mississippi State University) at Mississippi State University is gratefully acknowledged. This work is based upon work supported by the Department of Energy Southern Regional Center for Lightweight Innovative Design (SRCLID), under award number DE-EE0002323. This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof. NR 27 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1742-7061 EI 1878-7568 J9 ACTA BIOMATER JI Acta Biomater. PD JAN 15 PY 2017 VL 48 BP 300 EP 308 DI 10.1016/j.actbio.2016.10.033 PG 9 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA EJ5GY UT WOS:000393247000025 PM 27793720 ER PT J AU Nagaraja, S Chen, L Zhou, J Zhao, Y Fine, D DiPietro, LA Reifman, J Mitrophanov, AY AF Nagaraja, Sridevi Chen, Lin Zhou, Jian Zhao, Yan Fine, David DiPietro, Luisa A. Reifman, Jaques Mitrophanov, Alexander Y. TI Predictive Analysis of Mechanistic Triggers and Mitigation Strategies for Pathological Scarring in Skin Wounds SO JOURNAL OF IMMUNOLOGY LA English DT Article ID GROWTH-FACTOR-BETA; HYPERTROPHIC SCAR; TRANSFORMING GROWTH-FACTOR-BETA-1; MATHEMATICAL-MODEL; MESSENGER-RNA; MATRIX METALLOPROTEINASES; SENSITIVITY-ANALYSIS; TOPICAL APPLICATION; SYSTEMS BIOLOGY; UNDERGO NETOSIS AB Wound fibrosis (i.e., excessive scar formation) is a medical problem of increasing prevalence, with poorly understood mechanistic triggers and limited therapeutic options. In this study, we employed an integrated approach that combines computational predictions with new experimental studies in mice to identify plausible mechanistic triggers of pathological scarring in skin wounds. We developed a computational model that predicts the time courses for six essential cell types, 18 essential molecular mediators, and collagen, which are involved in inflammation and proliferation during wound healing. By performing global sensitivity analyses using thousands of model-simulated wound-healing scenarios, we identified five key processes (among the 90 modeled processes) whose dysregulation may lead to pathological scarring in wounds. By modulating a subset of these key processes, we simulated fibrosis in wounds. Moreover, among the 18 modeled molecular mediators, we identified TGF-beta and the matrix metalloproteinases as therapeutic targets whose modulation may reduce fibrosis. The model predicted that simultaneous modulation of TGF-beta and matrix metalloproteinases would be more effective in treating excessive scarring than modulation of either therapeutic target alone. Our model was validated with previously published and newly generated experimental data, and suggested new in vivo experiments. C1 [Nagaraja, Sridevi; Chen, Lin; Zhou, Jian; Zhao, Yan; Fine, David; DiPietro, Luisa A.; Reifman, Jaques; Mitrophanov, Alexander Y.] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr,Dept Def Biotechnol, High Performance Comp Software Applicat Inst, MCMR TT,504 Scott St, Ft Detrick, MD 21702 USA. Univ Illinois, Ctr Wound Healing & Tissue Regenerat, Coll Dent, Chicago, IL 60612 USA. RP Reifman, J (reprint author), US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr,Dept Def Biotechnol, High Performance Comp Software Applicat Inst, MCMR TT,504 Scott St, Ft Detrick, MD 21702 USA. EM jaques.reifman.civ@mail.mil OI DiPietro, Luisa Ann/0000-0002-4842-1547 FU Clinical and Rehabilitative Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX This work was supported by the Clinical and Rehabilitative Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. NR 74 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 EI 1550-6606 J9 J IMMUNOL JI J. Immunol. PD JAN 15 PY 2017 VL 198 IS 2 BP 832 EP 841 DI 10.4049/jimmunol.1601273 PG 10 WC Immunology SC Immunology GA EI3PZ UT WOS:000392405000032 PM 27956530 ER PT J AU Bell, KR Fann, JR Brockway, JA Cole, WR Bush, NE Dikmen, S Hart, T Lang, AJ Grant, G Gahm, G Reger, MA St De Lore, J Machamer, J Ernstrom, K Raman, R Jain, S Stein, MB Temkin, N AF Bell, Kathleen R. Fann, Jesse R. Brockway, Jo Ann Cole, Wesley R. Bush, Nigel E. Dikmen, Sureyya Hart, Tessa Lang, Ariel J. Grant, Gerald Gahm, Gregory Reger, Mark A. St De Lore, Jef Machamer, Joan Ernstrom, Karin Raman, Rema Jain, Sonia Stein, Murray B. Temkin, Nancy CA INTRuST Investigators TI Telephone Problem Solving for Service Members with Mild Traumatic Brain Injury: A Randomized, Clinical Trial SO JOURNAL OF NEUROTRAUMA LA English DT Article DE mild traumatic brain injury; problem-solving treatment (or training or therapy); service members (or military); telehealth ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH-CARE; 1ST YEAR; DEPRESSION; SYMPTOMS; INTERVENTION; THERAPY; VETERANS; PTSD; RELIABILITY AB Mild traumatic brain injury (mTBI) is a common injury for service members in recent military conflicts. There is insufficient evidence of how best to treat the consequences of mTBI. In a randomized, clinical trial, we evaluated the efficacy of telephone-delivered problem-solving treatment (PST) on psychological and physical symptoms in 356 post-deployment active duty service members from Joint Base Lewis McChord, Washington, and Fort Bragg, North Carolina. Members with medically confirmed mTBI sustained during deployment to Iraq and Afghanistan within the previous 24 months received PST or education-only (EO) interventions. The PST group received up to 12 biweekly telephone calls from a counselor for subject-selected problems. Both groups received 12 educational brochures describing common mTBI and post-deployment problems, with follow-up for all at 6 months (end of PST), and at 12 months. At 6 months, the PST group significantly improved on a measure of psychological distress (Brief Symptom Inventory; BSI-18) compared to the EO group (p = 0.005), but not on post-concussion symptoms (Rivermead Post-Concussion Symptoms Questionnaire [RPQ]; p = 0.19), the two primary endpoints. However, these effects did not persist at 12-month follow-up (BSI, p = 0.54; RPQ, p = 0.45). The PST group also had significant short-term improvement on secondary endpoints, including sleep (p = 0.01), depression (p = 0.03), post-traumatic stress disorder (p = 0.04), and physical functioning (p = 0.03). Participants preferred PST overEO(p < 0.001). Telephone-delivered PST appears to be a well-accepted treatment that offers promise for reducing psychological distress after combat-related mTBI and could be a useful adjunct treatment post-mTBI. Further studies are required to determine how to sustain its effects. (Trial registration: ClinicalTrials.gov Identifier: NCT01387490 https://clinicaltrials. gov) C1 [Bell, Kathleen R.; Fann, Jesse R.; Brockway, Jo Ann; Dikmen, Sureyya; Machamer, Joan; Temkin, Nancy] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. [Fann, Jesse R.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA. [Cole, Wesley R.] Womack Army Med Ctr, Def & Vet Brain Injury Ctr, Intrepid Spirit, Ft Bragg, NC USA. [Bush, Nigel E.; Gahm, Gregory; Reger, Mark A.] Natl Ctr Telehealth & Technol, Joint Base Lewis McChord, Tacoma, WA USA. [Dikmen, Sureyya; St De Lore, Jef; Temkin, Nancy] Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA. [Hart, Tessa] Moss Rehabil Res Inst, Elkins Pk, PA USA. [Lang, Ariel J.; Stein, Murray B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA. [Lang, Ariel J.; Stein, Murray B.] VA San Diego Healthcare Syst Ctr Excellence Stres, La Jolla, CA 92093 USA. [Grant, Gerald] Duke Univ, Dept Surg, Durham, NC USA. [Ernstrom, Karin; Raman, Rema; Jain, Sonia; Stein, Murray B.] Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA. [Temkin, Nancy] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Bell, Kathleen R.] Univ Texas Southwestern, Dept Phys Med & Rehabil, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. [Grant, Gerald] Stanford Univ, Dept Neurosurg, Palo Alto, CA 94304 USA. [Ernstrom, Karin; Raman, Rema] Univ Southern Calif, Alzheimers Therapeut Res Inst, San Diego, CA USA. RP Bell, KR (reprint author), Univ Texas Southwestern, Dept Phys Med & Rehabil, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. EM Kathleen.Bell@UTSouthwestern.edu FU U.S. Army Medical Research and Materiel Command (USAMRMC) [W81XWH-08-2-0159]; National Institute on Disability and Rehabilitation Research [H133G070143] FX This study was supported by the U.S. Army Medical Research and Materiel Command (USAMRMC; contract no.: W81XWH-08-2-0159). Supplementary support was provided by the National Institute on Disability and Rehabilitation Research (grant no.: H133G070143). NR 41 TC 0 Z9 0 U1 7 U2 7 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 EI 1557-9042 J9 J NEUROTRAUM JI J. Neurotrauma PD JAN 15 PY 2017 VL 34 IS 2 BP 313 EP 321 DI 10.1089/neu.2016.4444 PG 9 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA EH4QD UT WOS:000391754800006 PM 27579992 ER PT J AU Peluso, MJ Valcour, V Phanuphak, N Ananworanich, J Fletcher, JLK Chalermchai, T Krebs, SJ Robb, ML Hellmuth, J Gisslen, M Zetterberg, H Spudich, S AF Peluso, Michael J. Valcour, Victor Phanuphak, Nittaya Ananworanich, Jintanat Fletcher, James L. K. Chalermchai, Thep Krebs, Shelly J. Robb, Merlin L. Hellmuth, Joanna Gisslen, Magnus Zetterberg, Henrik Spudich, Serena CA RV254-SEARCH 010 Study Team RV304 SEARCH 013 Study Team SEARCH 011 Study Team TI Immediate initiation of cART is associated with lower levels of cerebrospinal fluid YKL-40, a marker of microglial activation, in HIV-1 infection SO AIDS LA English DT Article DE acute HIV; central nervous system; cerebrospinal fluid; combination antiretroviral therapy; HIV; microglia; microglial activation; neuroinflammation; neuronal injury; neuropathogenesis; YKL-40 ID ALZHEIMERS-DISEASE; INFLAMMATION; BIOMARKER; INJURY AB Objective: To characterize cerebrospinal fluid (CSF) YKL-40, a unique biomarker that reflects activation of microglial cells, in acute (AHI) and chronic HIV-1 infection (CHI) and to determine the effect of treatment initiation on levels of this marker. Design: A cross-sectional study of two groups of HIV-infected participants at baseline and follow-up timepoints. Methods: AHI (n = 33) and CHI (n = 34) participants underwent CSF and blood sampling before treatment initiation with combination antiretroviral therapy (cART) and at follow-up on cART in a subset of these individuals [6 months in AHI participants (n = 24), 1 year in CHI participants (n = 10)]. Measured parameters were analyzed at each timepoint. Analyses employed Mann-Whitney tests and Spearman correlations. Results: Baseline median YKL-40 was higher in CHI than AHI (96844 versus 80754 ng/l; P = 0.011). Elevations in the CHI group relative to the AHI group persisted at follow-up despite treatment (87414 versus 66130 ng/l; P = 0.003). In untreated CHI, YKL-40 correlated with neopterin (r = 0.51, P = 0.0025), chemokine (CXC-motif) ligand-10 (r = 0.44, P = 0.011), and neurofilament light chain (r = 0.56, P = 0.0008) in CSF. Conclusions: This study is the first to describe the dynamics of CSF YKL-40 in two groups of HIV-infected individuals before and after cART and demonstrates the value of this marker in understanding HIV neuropathogenesis. The results suggest the utility of further exploring the prognostic value of YKL-40, particularly in individuals with early HIV infection or those initiating treatment during CHI. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved. C1 [Peluso, Michael J.] Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA. [Valcour, Victor; Hellmuth, Joanna] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA. [Phanuphak, Nittaya; Ananworanich, Jintanat; Fletcher, James L. K.; Chalermchai, Thep] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand. [Ananworanich, Jintanat; Krebs, Shelly J.; Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat; Krebs, Shelly J.; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Gisslen, Magnus] Inst Biomed, Dept Infect Dis, Gothenburg, Sweden. [Zetterberg, Henrik] Univ Gothenburg, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Sahlgrenska Acad, Molndal, Sweden. [Zetterberg, Henrik] UCL, Inst Neurol, London, England. [Spudich, Serena] Yale Univ, Sch Med, New Haven, CT USA. RP Spudich, S (reprint author), Yale Univ, Sch Med, New Haven, CT USA. EM serena.spudich@yale.edu FU National Institutes of Health [R01MH095613, R01NS084911, R01BS061696]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc [W81XWH-07-2-0067]; U.S. Department of Defense (DoD) [W81XWH-07-2-0067] FX We thank our study participants and staff from the Thai Red Cross AIDS Research Centre, Chulalongkorn University and AFRIMS for their valuable contributions to this study. We are grateful to the Government Pharmaceutical Organization, Thailand (GPO), ViiV Healthcare, Gilead and Merck for providing the antiretroviral medications for this study. This work is supported by National Institutes of Health grants R01MH095613 (VV and SS), R01NS084911 (JA and SS), R01BS061696 (VV), and a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, and the U.S. Department of Defense (DoD). NR 21 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD JAN 14 PY 2017 VL 31 IS 2 BP 247 EP 252 DI 10.1097/QAD.0000000000001314 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EF6PK UT WOS:000390452800010 PM 27819802 ER PT J AU Hornbuckle, BC Murdoch, HA Roberts, AJ Kecskes, LJ Tschopp, MA Doherty, KJ Yu, JH Darling, KA AF Hornbuckle, B. C. Murdoch, H. A. Roberts, A. J. Kecskes, L. J. Tschopp, M. A. Doherty, K. J. Yu, J. H. Darling, K. A. TI Property mapping of friction stir welded Al-2139 T8 plate using site specific shear punch testing SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Friction stir weld; Shear punch testing; Property mapping ID MECHANICAL-PROPERTIES; ALUMINUM-ALLOY; STRENGTHENING MECHANISMS; MICROSTRUCTURE EVOLUTION; GRAIN-STRUCTURE; MG; CU; BEHAVIOR; TENSILE; AA2024 AB Small-scale shear punch testing has been applied to a butt joint created by friction stir welding of two adjoining AA2139-T8 plates. Advantages of this technique include the ability to perform a large number of independent tests on a given volume of material and the ability to measure site-specific differences and variations in local material properties. As such, combined with a simultaneous evaluation of the weld morphology, a series of 144 shear punch tests were carried out in a 12x12 grid pattern on the retreating half of the weld. The overlay of the grid pattern onto the etched surface allowed a correlation of the microstructure and mechanical properties measured across the weld at each shear punch site. Two-dimensional color enhanced property maps were generated to provide a powerful site specific visualization of the unique or distinctive microstructural features and how they correlate with the local mechanical response across the weld. One of the more insightful discoveries was the weld nugget region undergoing 2.5 times more strain-hardening than the base plate material, while simultaneously experiencing the Portevin-LeChatelier effect. Aspects of the technique and results of our experiments are described. C1 [Hornbuckle, B. C.; Murdoch, H. A.; Roberts, A. J.; Kecskes, L. J.; Tschopp, M. A.; Doherty, K. J.; Darling, K. A.] US Army, Res Lab, Weap & Mat Res Directorate, Lightweight & Specialty Met Branch,RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. [Yu, J. H.] US Army, Res Lab, Weap & Mat Res Directorate, Mat Response & Design Branch,RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP Hornbuckle, BC (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Lightweight & Specialty Met Branch,RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. EM billy.c.hornbuckle.ctr@mail.mil OI Tschopp, Mark/0000-0001-8471-5035 FU U.S. Army Research Laboratory [W911QX-14-C-0016] FX BCH acknowledges support by an appointment to Postdoctoral Fellowship at the U.S. Army Research Laboratory, administered by the Oak Ridge Institute for Science and Education (ORISE) under contract number W911QX-14-C-0016. Lastly, the authors thank James Catalano and Micah Gallagher for their assistance in sectioning, polishing, and etching of the friction stir welded plate for microstructural analysis. NR 62 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JAN 13 PY 2017 VL 682 BP 192 EP 201 DI 10.1016/j.msea.2016.11.032 PG 10 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA EJ1XM UT WOS:000393003800022 ER PT J AU Epstein, JE Paolino, KM Richie, TL Sedegah, M Singer, A Ruben, AJ Chakravarty, S Stafford, A Ruck, RC Eappen, AG Li, T Billingsley, PF Manoj, A Silva, JC Moser, K Nielsen, R Tosh, D Cicatelli, S Ganeshan, H Case, J Padilla, D Davidson, S Garver, L Saverino, E Murshedkar, T Gunasekera, A Twomey, PS Reyes, S Moon, JE James, ER Natasha, KC Li, ML Abot, E Belmonte, A Hauns, K Belmonte, M Huang, J Vasquez, C Remich, S Carrington, M Abebe, Y Tillman, A Hickey, B Regules, J Villasante, E Sim, BKL Hoffman, SL AF Epstein, Judith E. Paolino, Kristopher M. Richie, Thomas L. Sedegah, Martha Singer, Alexandra Ruben, Adam J. Chakravarty, Sumana Stafford, April Ruck, Richard C. Eappen, Abraham G. Li, Tao Billingsley, Peter F. Manoj, Anita Silva, Joana C. Moser, Kara Nielsen, Robin Tosh, Donna Cicatelli, Susan Ganeshan, Harini Case, Jessica Padilla, Debbie Davidson, Silas Garver, Lindsey Saverino, Elizabeth Murshedkar, Tooba Gunasekera, Anusha Twomey, Patrick S. Reyes, Sharina Moon, James E. James, Eric R. Natasha, K. C. Li, Minglin Abot, Esteban Belmonte, Arnel Hauns, Kevin Belmonte, Maria Huang, Jun Vasquez, Carlos Remich, Shon Carrington, Mary Abebe, Yonas Tillman, Amy Hickey, Bradley Regules, Jason Villasante, Eileen Sim, B. Kim Lee Hoffman, Stephen L. TI Protection against Plasmodium falciparum malaria by PfSPZ Vaccine SO JCI INSIGHT LA English DT Article ID NONREPLICATING SPOROZOITE VACCINE; T-CELLS RECOGNIZE; CIRCUMSPOROZOITE PROTEIN; IMMUNITY; IMMUNIZATION; HEPATOCYTES; ANTIBODIES; EFFICACY; PEPTIDE; INVITRO AB BACKGROUND: A radiation-attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf (same strain as in the vaccine) controlled human malaria infection (CHMI) 3 weeks after 5 doses administered intravenously. The next step was to assess protective efficacy against heterologous Pf (different from Pf in the vaccine), after fewer doses, and at 24 weeks. METHODS: The trial assessed tolerability, safety, immunogenicity, and protective efficacy of direct venous inoculation (DVI) of 3 or 5 doses of PfSPZ Vaccine in non-immune subjects. RESULTS: Three weeks after final immunization, 5 doses of 2.7 x 10(5) PfSPZ protected 12 of 13 recipients (92.3% [95% CI: 48.0, 99.8]) against homologous CHMI and 4 of 5 (80.0% [10.4, 99.5]) against heterologous CHMI; 3 doses of 4.5 x 10(5) PfSPZ protected 13 of 15 (86.7% [35.9, 98.3]) against homologous CHMI. Twenty-four weeks after final immunization, the 5-dose regimen protected 7 of 10 (70.0% [17.3, 93.3]) against homologous and 1 of 10 (10.0% [-35.8, 45.6]) against heterologous CHMI; the 3-dose regimen protected 8 of 14 (57.1% [21.5, 76.6]) against homologous CHMI. All 22 controls developed Pf parasitemia. PfSPZ Vaccine was well tolerated, safe, and easy to administer. No antibody or T cell responses correlated with protection. CONCLUSIONS: We have demonstrated for the first time to our knowledge that PfSPZ Vaccine can protect against a 3-week heterologous CHMI in a limited group of malaria-naive adult subjects. A 3-dose regimen protected against both 3-week and 24-week homologous CHMI (87% and 57%, respectively) in this population. These results provide a foundation for developing an optimized immunization regimen for preventing malaria. C1 [Epstein, Judith E.; Sedegah, Martha; Singer, Alexandra; Ganeshan, Harini; Reyes, Sharina; Abot, Esteban; Belmonte, Arnel; Belmonte, Maria; Huang, Jun; Vasquez, Carlos; Carrington, Mary; Villasante, Eileen] Naval Med Res Ctr, Silver Spring, MD USA. [Paolino, Kristopher M.; Stafford, April; Ruck, Richard C.; Nielsen, Robin; Tosh, Donna; Cicatelli, Susan; Davidson, Silas; Garver, Lindsey; Twomey, Patrick S.; Moon, James E.; Hauns, Kevin; Remich, Shon; Hickey, Bradley; Regules, Jason] Walter Reed Army Inst Res, Silver Spring, MD USA. [Richie, Thomas L.; Ruben, Adam J.; Chakravarty, Sumana; Eappen, Abraham G.; Li, Tao; Billingsley, Peter F.; Manoj, Anita; Padilla, Debbie; Saverino, Elizabeth; Murshedkar, Tooba; James, Eric R.; Natasha, K. C.; Li, Minglin; Abebe, Yonas; Sim, B. Kim Lee; Hoffman, Stephen L.] Sanaria Inc, 9800 Med Ctr Dr,Suite A209, Rockville, MD 20805 USA. [Silva, Joana C.; Moser, Kara] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA. [Case, Jessica; Tillman, Amy] Stat Collaborat Inc, Washington, DC USA. [Natasha, K. C.; Li, Minglin; Sim, B. Kim Lee] Prot Potential, Rockville, MD USA. [Paolino, Kristopher M.] SUNY Upstate Med Univ, Ctr Global Hlth & Translat Sci, New York, NY USA. [Stafford, April] Virginia Canc Specialists, Arlington, VA USA. [Ruck, Richard C.] US Armys Hlth Clin Schofield Barracks, Schofield Barracks, HI USA. [Nielsen, Robin] Clin Res Management, Frederick, MD USA. [Padilla, Debbie] Univ Virginia, Charlottesville, VA USA. [Davidson, Silas] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Hauns, Kevin] US Army Med Directorate, Armed Forces Res Inst Med Serv, Bangkok, Thailand. [Vasquez, Carlos] Bio Clin Inc, Newark, CA USA. [Carrington, Mary] USS Ashland LSD 48, Lexington, KY USA. Navy Expt Diving Unit Med Dept, Panama City, FL USA. [Regules, Jason] US Army Med Res Inst Infect Dis, Dept Clin Res, Frederick, MD USA. RP Hoffman, SL (reprint author), Sanaria Inc, 9800 Med Ctr Dr,Suite A209, Rockville, MD 20805 USA. EM slhoffman@sanaria.com FU Department of Defense [W81XWH1420011]; Naval Medical Research Center's Advanced Medical Development Program; Military Infectious Diseases Research Program; National Institute of Allergy and Infectious Diseases [U19AI10820]; [A1217] FX We thank the volunteers for their participation and the PfSPZ Vaccine Development Teams (see supplemental material) for their incredible efforts. The trial was supported primarily by Department of Defense Award/Contract W81XWH1420011; this included production and characterization of the vaccine. Additional funds were provided by the Naval Medical Research Center's Advanced Medical Development Program and the Military Infectious Diseases Research Program. At the NMRC, work was funded by Work Unit Number A1217. JCS and KM were supported by grant U19AI10820 from the National Institute of Allergy and Infectious Diseases. All of the data reported in the manuscript are tabulated in the main text and in the supporting online material. A number of patents on PfSPZ have been issued, allowed, or filed in the USA and internationally. NR 32 TC 1 Z9 1 U1 2 U2 2 PU AMER SOC CLINICAL INVESTIGATION INC PI ANN ARBOR PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA SN 2379-3708 J9 JCI INSIGHT JI JCI Insight PD JAN 12 PY 2017 VL 2 IS 1 AR e89154 DI 10.1172/jci.insight.89154 PG 14 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EK0BO UT WOS:000393591600004 PM 28097230 ER PT J AU Bremer, PT Adler, M Phung, CH Singh, AK Janda, KD AF Bremer, Paul T. Adler, Michael Phung, Cecilia H. Singh, Ajay K. Janda, Kim D. TI Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID SMALL-MOLECULE INHIBITORS; TOXIN TYPE-A; CONFORMER GENERATION; DOUBLE-BLIND; SEROTYPE; IDENTIFICATION; PROTEASE; POTENT; METALLOPROTEASE; SUBSTRATE AB Botulinurn neurotoxin A (BoNT/A) is one of the most deadly toxins and is the etiological agent of the potentially fatal condition, botulism. Herein, we investigated 8-hydroxyquinoline (quinolin-8-ol) as a potential inhibitor scaffold for preventing the deadly neurochemical effects of the toxin. Quinolinols are known chelators that can disrupt the BoNT/A metalloprotease zinc-containing active site, thus impeding its proteolysis of the endogenous protein substrate, synaptosomalassociated protein 25 (SNAP-25). By use of this information, the structure-activity relationship (SAR) of the quinolino1-5-sulfonamide scaffold was explored through preparation of a crude sulfonamide library and evaluation of the library in a BoNT/A LC enzymatic assay. Potency optimization of the sulfonamide hit compounds was undertaken as informed by docking studies, granting a lead compound with a submicromolar K-i. These quinolinol analogues demonstrated inhibitory activity in a cell-based model for SNAP-25 cleavage and an ex vivo assay for BoNT/A-mediated muscle paralysis. C1 [Bremer, Paul T.; Janda, Kim D.] Scripps Res Inst, WIRM, Skaggs Inst Chem Biol, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA. [Bremer, Paul T.; Janda, Kim D.] Scripps Res Inst, WIRM, Skaggs Inst Chem Biol, Dept Immunol, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA. [Adler, Michael; Phung, Cecilia H.; Singh, Ajay K.] US Army, Med Res Inst Chem Def, Analyt Toxicol Div, Neurobehav Toxicol Branch, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. RP Janda, KD (reprint author), Scripps Res Inst, WIRM, Skaggs Inst Chem Biol, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA.; Janda, KD (reprint author), Scripps Res Inst, WIRM, Skaggs Inst Chem Biol, Dept Immunol, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA. EM kdjanda@scripps.edu FU NIH [R01AI119564]; Defense Threat Reduction Agency; Joint Science and Technology Office; Medical ST Division [CB4080] FX We thank the funding support from NIH Grant R01AI119564 (K.D.J.), The Defense Threat Reduction Agency, Joint Science and Technology Office, and Medical S&T Division, Award CB4080 (M.A.). We also acknowledge Alex Ducime for synthesis of some inactive quinolinols and OpenEye software for use of their docking software under an academic license. This is TSRI manuscript no. 29418. NR 52 TC 1 Z9 1 U1 3 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 EI 1520-4804 J9 J MED CHEM JI J. Med. Chem. PD JAN 12 PY 2017 VL 60 IS 1 BP 338 EP 348 DI 10.1021/acs.jmedchem.6b01393 PG 11 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA EH8PP UT WOS:000392035100022 PM 27966961 ER PT J AU Woo, HJ Yu, CG Reifman, J AF Woo, Hyung Jun Yu, Chenggang Reifman, Jaques TI Collective Genetic Interaction Effects and the Role of Antigen-Presenting Cells in Autoimmune Diseases SO PLOS ONE LA English DT Article ID GENOME-WIDE ASSOCIATION; THYMIC B-CELLS; MHC CLASS-I; T-CELLS; NEGATIVE SELECTION; SELF-ANTIGENS; RISK; MECHANISMS; TOLERANCE; ARTHRITIS AB Autoimmune diseases occur when immune cells fail to develop or lose their tolerance toward self and destroy body's own tissues. Both insufficient negative selection of self-reactive T cells and impaired development of regulatory T cells preventing effector cell activation are believed to contribute to autoimmunity. Genetic predispositions center around the major histocompatibility complex (MHC) class II loci involved in antigen presentation, the key determinant of CD4(+) T cell activation. Recent studies suggested that variants in the MHC region also exhibit significant non-additive interaction effects. However, collective interactions involving large numbers of single nucleotide polymorphisms (SNPs) contributing to such effects are yet to be characterized. In addition, relatively little is known about the celltype-specificity of such interactions in the context of cellular pathways. Here, we analyzed type 1 diabetes (T1D) and rheumatoid arthritis (RA) genome-wide association data sets via large-scale, high-performance computations and inferred collective interaction effects involving MHC SNPs using the discrete discriminant analysis. Despite considerable differences in the details of SNP interactions in T1D and RA data, the enrichment pattern of interacting pairs in reference epigenomes was remarkably similar: statistically significant interactions were epigenetically active in cell-type combinations connecting B cells to T cells and intestinal epithelial cells, with both helper and regulatory T cells showing strong disease-associated interactions with B cells. Our results provide direct genetic evidence pointing to the important roles B cells play as antigen-presenting cells toward CD4(+) T cells in the context of central and peripheral tolerance. In addition, they are consistent with recent experimental studies suggesting that the repertoire of B cell-specific self-antigens in the thymus are critical to the effective control of corresponding autoimmune activation in peripheral tissues. C1 [Woo, Hyung Jun; Yu, Chenggang; Reifman, Jaques] US Army, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Woo, HJ; Reifman, J (reprint author), US Army, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM woo@bhsai.org; jaques.reifman.civ@mail.mil FU U.S. Army Medical Research and Materiel Command FX Support was provided by the U.S. Army Medical Research and Materiel Command. NR 60 TC 0 Z9 0 U1 2 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 12 PY 2017 VL 12 IS 1 AR e0169918 DI 10.1371/journal.pone.0169918 PG 27 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EH7JQ UT WOS:000391949500102 PM 28081217 ER PT J AU Hoest, C Seidman, JC Lee, G Platts-Mills, JA Ali, A Olortegui, MP Bessong, P Chandyo, R Babji, S Mohan, VR Mondal, D Mahfuz, M Mduma, ER Nyathi, E Abreu, C Miller, MA Pan, W Mason, CJ Knobler, SL AF Hoest, Christel Seidman, Jessica C. Lee, Gwenyth Platts-Mills, James A. Ali, Asad Paredes Olortegui, Maribel Bessong, Pascal Chandyo, Ram Babji, Sudhir Mohan, Venkata Raghava Mondal, Dinesh Mahfuz, Mustafa Mduma, Estomih R. Nyathi, Emanuel Abreu, Claudia Miller, Mark A. Pan, William Mason, Carl J. Knobler, Stacey L. CA MAL-ED Network Investigators TI Vaccine coverage and adherence to EPI schedules in eight resource poor settings in the MAL-ED cohort study SO VACCINE LA English DT Article DE Public health; Vaccine coverage; Vaccine timing; EPI; Socioeconomic factors; Measles ID IMMUNIZATION COVERAGE; ENTERIC INFECTIONS; BIRTH COHORT; SOUTH-AFRICA; RISK-FACTORS; TIMELINESS; POLIO; SITE; MALNUTRITION; NETWORK AB Background: Launched in 1974, the Expanded Program on Immunization (EPI) is estimated to prevent two-three million deaths annually from polio, diphtheria, tuberculosis, pertussis, measles, and tetanus. Additional lives could be saved through better understanding what influences adherence to the EPI schedule in specific settings. Methods: The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study followed cohorts in eight sites in South Asia, Africa, and South America and monitored vaccine receipt over the first two years of life for the children enrolled in the study. Vaccination histories were obtained monthly from vaccination cards, local clinic records and/or caregiver reports. Vaccination histories were compared against the prescribed EPI schedules for each country, and coverage rates were examined in relation to the timing of vaccination. The influence of socioeconomic factors on vaccine timing and coverage was also considered. Results: Coverage rates for EPI vaccines varied between sites and by type of vaccine; overall, coverage was highest in the Nepal and Bangladesh sites and lowest in the Tanzania and Brazil sites. Bacillus Calmette-Guerin coverage was high across all sites, 87-100%, whereas measles vaccination rates ranged widely, 73-100%. Significant delays between the scheduled administration age and actual vaccination date were present in all sites, especially for measles vaccine where less than 40% were administered on schedule. A range of socioeconomic factors were significantly associated with vaccination status in study children but these results were largely site-specific. Conclusions: Our findings highlight the need to improve measles vaccination rates and reduce delayed vaccination to achieve EPI targets related to the establishment of herd immunity and reduction in disease transmission. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license. C1 [Hoest, Christel; Seidman, Jessica C.; Miller, Mark A.; Knobler, Stacey L.] Natl Inst Hlth, Fogarty Int Ctr, Div Int Epidemiol & Populat Studies Fogarty, 16 Ctr Dr,Bldg 16,Room 202, Bethesda, MD 20892 USA. [Lee, Gwenyth] Johns Hopkins Univ, Dept Int Hlth, Baltimore, MD 21205 USA. [Platts-Mills, James A.] Univ Virginia, Div Infect Dis & Int Hlth, POB 801340,345 Crispell Dr,Carter Harrison Bldg, Charlottesville, VA 22908 USA. [Ali, Asad] Aga Khan Univ, Dept Pediat & Child Hlth, Stadium Rd, Karachi, Pakistan. [Paredes Olortegui, Maribel] Asociac Benef Proyectos Informat Sauld Med & Agr, Ramirez Hurtado 622, Iquitos, Peru. [Bessong, Pascal] Univ Venda, HIV AIDS & Global Hlth Res Programme, ZA-0950 Thohoyandou, South Africa. [Chandyo, Ram] Tribhuvan Univ, Inst Med, Dept Child Hlth, Kathmandu, Nepal. [Chandyo, Ram] Univ Bergen, Ctr Int Hlth, POB 7800, N-5020 Bergen, Norway. [Babji, Sudhir; Mohan, Venkata Raghava] Christian Med Coll & Hosp, Dept Community Hlth, Dept Gastrointestinal Sci, Vellore 632004, Tamil Nadu, India. [Mondal, Dinesh; Mahfuz, Mustafa] Int Ctr Diarrhoeal Dis Res, Nutr & Clin Serv Div, 68 Shaheed Tajuddin Ahmed Sarani, Dhaka 1212, Bangladesh. [Mduma, Estomih R.] Haydom Lutheran Hosp, POB 9041, Haydom, Manyara Region, Tanzania. [Abreu, Claudia; MAL-ED Network Investigators] Univ Fed Ceara, Fac Med, Inst Biomed, Dept Fisiol & Farmacol, Rua Coronel Nunes Melo 1315,CP 3229, BR-60430270 Fortaleza, Ceara, Brazil. [Pan, William] Duke Univ, Dept Environm Sci & Policy, Durham, NC USA. [Pan, William] Duke Univ, Duke Global Hlth Inst, Durham, NC USA. [Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok, Thailand. RP Hoest, C (reprint author), Natl Inst Hlth, Fogarty Int Ctr, Div Int Epidemiol & Populat Studies Fogarty, 16 Ctr Dr,Bldg 16,Room 202, Bethesda, MD 20892 USA. EM christel.host@nih.gov OI Ali, Syed Asad/0000-0001-5274-7665 FU Bill & Melinda Gates Foundation; Foundation for the NIH; National Institutes of Health, Fogarty International Center FX The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) is carried out as a collaborative project supported by the Bill & Melinda Gates Foundation, the Foundation for the NIH, and the National Institutes of Health, Fogarty International Center. NR 32 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 11 PY 2017 VL 35 IS 3 BP 443 EP 451 DI 10.1016/j.vaccine.2016.11.075 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA EJ2AK UT WOS:000393011900006 PM 27998640 ER PT J AU Scott, JB Ward, CL Corona, BT Deschenes, MR Harrison, BS Saul, JM Christ, GJ AF Scott, John B. Ward, Catherine L. Corona, Benjamin T. Deschenes, Michael R. Harrison, Benjamin S. Saul, Justin M. Christ, George J. TI Achieving Acetylcholine Receptor Clustering in Tissue-Engineered Skeletal Muscle Constructs In vitro through a Materials-Directed Agrin Delivery Approach SO FRONTIERS IN PHARMACOLOGY LA English DT Article DE bioreactor; drug delivery; fibrin; microspheres; tissue engineering; regenerative medicine ID MESENCHYMAL STEM-CELLS; ALTERNATIVELY SPLICED ISOFORMS; NEUROMUSCULAR-JUNCTION; SATELLITE CELLS; MURINE MODEL; LOSS INJURY; EXTRACELLULAR-MATRIX; MOLECULAR REGULATION; FUNCTIONAL RECOVERY; REPAIR CONSTRUCT AB Volumetric muscle loss (VML) can result from trauma, infection, congenital anomalies, or surgery, and produce permanent functional and cosmetic deficits. There are no effective treatment options for VML injuries, and recent advances toward development of muscle constructs lack the ability to achieve innervation necessary for long-term function. We sought to develop a proof-of-concept biomaterial construct that could achieve acetylcholine receptor (AChR) clustering on muscle-derived cells (MDCs) in vitro. The approach consisted of the presentation of neural (Z+) agrin from the surface of microspheres embedded with a fibrin hydrogel to muscle cells (C2C12 cell line or primary rat MDCs). AChR clustering was spatially restricted to areas of cell (C2C12)-microsphere contact when the microspheres were delivered in suspension or when they were incorporated into a thin (2D) fibrin hydrogel. AChR clusters were observed from 16 to 72 h after treatment when Z+ agrin was adsorbed to the microspheres, and for greater than 120 h when agrin was covalently coupled to the microspheres. Little to no AChR clustering was observed when agrin-coated microspheres were delivered from specially designed 3D fibrin constructs. However, cyclic stretch in combination with agrin-presenting microspheres led to dramatic enhancement of AChR clustering in cells cultured on these 3D fibrin constructs, suggesting a synergistic effect between mechanical strain and agrin stimulation of AChR clustering in vitro. These studies highlight a strategy for maintaining a physiological phenotype characterized by motor endplates of muscle cells used in tissue engineering strategies for muscle regeneration. As such, these observations may provide an important first step toward improving function of tissue-engineered constructs for treatment of VML injuries. C1 [Scott, John B.; Ward, Catherine L.; Corona, Benjamin T.; Harrison, Benjamin S.; Christ, George J.] Wake Forest Univ Hlth Sci, Wake Forest Inst Regenerat Med, Winston Salem, NC USA. [Scott, John B.; Harrison, Benjamin S.] Wake Forest Univ Biomed Engn, Wake Forest Univ, Sch Biomed Engn, Virginia Tech, Winston Salem, NC USA. [Ward, Catherine L.; Corona, Benjamin T.] US Army Inst Surg Res, San Antonio, TX USA. [Deschenes, Michael R.] Coll William & Mary, Dept Neurosci, Williamsburg, VA USA. [Saul, Justin M.] Miami Univ, Dept Chem Paper & Biomed Engn, Oxford, OH 45056 USA. [Christ, George J.] Univ Virginia, Dept Biomed Engn, Charlottesville, VA USA. [Christ, George J.] Univ Virginia, Dept Orthopaed Surg, Charlottesville, VA USA. RP Saul, JM (reprint author), Miami Univ, Dept Chem Paper & Biomed Engn, Oxford, OH 45056 USA. EM sauljm@MiamiOH.edu FU Telemedicine and Advanced Technology Research Center [W81XWH-12-1-0422]; National Institutes of Health [R01AR061391]; Wake Forest University Department of Biomedical Engineering; Wake Forest Institute for Regenerative Medicine FX This work was funded by an award from the Telemedicine and Advanced Technology Research Center (W81XWH-12-1-0422, GC). This work was also supported by the National Institutes of Health (JMS; R01AR061391) and the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was also partially funded by the Wake Forest University Department of Biomedical Engineering, and by the Wake Forest Institute for Regenerative Medicine. The authors gratefully acknowledge the assistance of Hannah Baker, Christopher Bergman, Hayden Holbrook, Venu Kesireddy, Juliana Passipieri, Pooja Patil, Mevan Siriwardane, Claire Staley, and Taylor Zak in performing experiments; Cathy Mathis and Cynthia Zimmerman for their assistance with histology; Christopher Booth for his assistance in confocal microscopy; Judy Bohnert and Michael Rariden for blinded image analysis; and Dr. Frank Marini for critique of confocal micrographs. NR 98 TC 0 Z9 0 U1 7 U2 7 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1663-9812 J9 FRONT PHARMACOL JI Front. Pharmacol. PD JAN 11 PY 2017 VL 7 AR 508 DI 10.3389/fphar.2016.00508 PG 16 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EH3LB UT WOS:000391672000001 ER PT J AU Chadderton, C Foran, CM Rodriguez, G Gilbert, D Cosper, SD Linkov, I AF Chadderton, Colin Foran, Christy M. Rodriguez, Giselle Gilbert, Dominique Cosper, Steven D. Linkov, Igor TI Decision support for selection of food waste technologies at military installations SO JOURNAL OF CLEANER PRODUCTION LA English DT Article DE Multi-criteria decision analysis; Food waste; Sustainability; US Army; Technology selection ID MANAGEMENT; FRAMEWORK AB The selection of an appropriate technology for waste management in a way that enhances sustainability is a complex problem requiring information from multiple disciplines. This decision is made more complex for large, diverse organizations for which individual sites or components have different requirements and capacities for waste management. For U.S. Army installations, sustainable waste management is a major obstacle for resource constrained and overburdened installation personnel. The Army has prioritized landfill diversion at installations; there is a significant push for each installation to develop and implement waste management plans that follow high-level goals set by U.S. Army Installation Management Command (IMCOM). The main objective of this study is to demonstrate an excel based dashboard tool incorporating Multi-Criteria Decision Analysis (MCDA) for site-specific waste management technology selection. The dashboard uses the preferences of an installation and a series of weighted metrics to evaluate technologies. With this information the dashboard can rank the technologies to identify those that simultaneously meet IMCOM's objectives and are appropriate for specific sites' capabilities and resources. Fourteen different technology makes and models were compared in this version of the decision model including dehydrators, pulpers, garbage disposals, containerized in-vessel composting, windrow composting, forced-air static composting, and containerized anaerobic digestion. MCDA provides for transparent comparison of technologies for all sites, and the dashboard visualizes the level of appropriateness of each technology for each site. The approach developed here adds value in that it utilizes the priorities of the organization and identifies the best performing waste management technology given the specific capacity and capabilities of an individual site. Published by Elsevier Ltd. C1 [Chadderton, Colin; Foran, Christy M.; Linkov, Igor] US Army, Engineer Res & Dev Ctr, Environm Lab, Risk & Decis Sci, 696 Virginia Rd, Concord, MA 01742 USA. [Rodriguez, Giselle; Gilbert, Dominique; Cosper, Steven D.] US Army, Engineer Res & Dev Ctr, Construct Engn Res Lab, 2902 Newmark Dr, Champaign, IL 61826 USA. RP Foran, CM (reprint author), ERDC Environm Lab, Duty Stn, 696 Virginia Rd, Concord, MA 01742 USA. EM Christy.M.Foran@usace.army.mil FU U.S. Army Installation Management Command (IMCOM) FX This study was funded by the U.S. Army Installation Management Command (IMCOM), and permission was granted by USACE to publish this material. The authors would like to thank the technology manufacturers for the assessment data they have provided. The views and opinions expressed in this paper are those of the individual authors and not those of the U.S. Army, IMCOM, U.S. Army Engineer Research and Development Center or other sponsor organizations. NR 29 TC 0 Z9 0 U1 13 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0959-6526 EI 1879-1786 J9 J CLEAN PROD JI J. Clean Prod. PD JAN 10 PY 2017 VL 141 BP 267 EP 277 DI 10.1016/j.jclepro.2016.08.091 PG 11 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA ED7ZC UT WOS:000389090300026 ER PT J AU Ge, SP Habib, KMM De, A Barlas, Y Wickramaratne, D Neupane, MR Lake, RK AF Ge, Supeng Habib, K. M. Masum De, Amrit Barlas, Yafis Wickramaratne, Darshana Neupane, Mahesh R. Lake, Roger K. TI Interlayer transport through a graphene/rotated boron nitride/graphene heterostructure SO PHYSICAL REVIEW B LA English DT Article ID NITRIDE AB Interlayer electron transport through a graphene/hexagonal boron-nitride (h-BN)/graphene heterostructure is strongly affected by the misorientation angle. of the h-BN with respect to the graphene layers with different physical mechanisms governing the transport in different regimes of angle, Fermi level, and bias. The different mechanisms and their resulting signatures in resistance and current are analyzed using two different models, a tight-binding, nonequilibrium Green function model and an effective continuum model, and the qualitative features resulting from the two different models compare well. In the large-angle regime (theta > 4 degrees), the change in the effective h-BN band gap seen by an electron at the K point of the graphene causes the resistance to monotonically increase with angle by several orders of magnitude, reaching a maximum at theta = 30 degrees. It does not affect the peak-to-valley current ratios in devices that exhibit negative differential resistance. In the small-angle regime (theta < 4 degrees), umklapp processes open up new conductance channels that manifest themselves as nonmonotonic features in a plot of resistance versus Fermi level that can serve as experimental signatures of this effect. For small angles and high bias, the umklapp processes give rise to two new current peaks on either side of the direct tunneling peak. C1 [Ge, Supeng; Barlas, Yafis] Univ Calif Riverside, Dept Phys & Astron, Riverside, CA 92521 USA. [Habib, K. M. Masum; De, Amrit; Barlas, Yafis; Wickramaratne, Darshana; Neupane, Mahesh R.; Lake, Roger K.] Univ Calif Riverside, Dept Elect & Comp Engn, Riverside, CA 92521 USA. [Habib, K. M. Masum] Intel Corp, Santa Clara, CA 95054 USA. [Wickramaratne, Darshana] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. [Neupane, Mahesh R.] US Army Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. RP Ge, SP (reprint author), Univ Calif Riverside, Dept Phys & Astron, Riverside, CA 92521 USA. EM supeng.ge@email.ucr.edu; rlake@ece.ucr.edu FU FAME; STARnet; MARCO; DARPA; NSF [EFRI-1433395]; National Science Foundation [ACI-1053575] FX This work is supported in part by FAME, one of six centers of STARnet, a Semiconductor Research Corporation program sponsored by MARCO and DARPA and the NSF Grant No. EFRI-1433395. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation Grant No. ACI-1053575. NR 41 TC 0 Z9 0 U1 24 U2 24 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD JAN 6 PY 2017 VL 95 IS 4 AR 045303 DI 10.1103/PhysRevB.95.045303 PG 9 WC Physics, Condensed Matter SC Physics GA EG8ML UT WOS:000391311100003 ER PT J AU Patel, K Blair, V Douglas, J Dai, QL Liu, YH Ren, SQ Brennan, R AF Patel, Ketan Blair, Victoria Douglas, Justin Dai, Qilin Liu, Yaohua Ren, Shenqiang Brennan, Raymond TI Structural Effects of Lanthanide Dopants on Alumina SO SCIENTIFIC REPORTS LA English DT Article ID EARTH-DOPED ALUMINA; SOLID-STATE NMR; RARE-EARTH; THERMAL STABILIZATION; QUADRUPOLAR NUCLEI; CERAMIC COMPOSITES; THIN-FILMS; CATALYSTS; COMBUSTION; STABILITY AB Lanthanide (Ln(3+)) doping in alumina has shown great promise for stabilizing and promoting desirable phase formation to achieve optimized physical and chemical properties. However, doping alumina with Ln elements is generally accompanied by formation of new phases (i.e. LnAlO(3), Ln(2)O(3)), and therefore inclusion of Ln-doping mechanisms for phase stabilization of the alumina lattice is indispensable. In this study, Ln-doping (400 ppm) of the alumina lattice crucially delays the onset of phase transformation and enables phase population control, which is achieved without the formation of new phases. The delay in phase transition (theta -> alpha), and alteration of powder morphology, particle dimensions, and composition ratios between alpha- and theta-alumina phases are studied using a combination of solid state nuclear magnetic resonance, electron microscopy, digital scanning calorimetry, and high resolution X-ray diffraction with refinement fitting. Loading alumina with a sparse concentration of Ln-dopants suggests that the dopants reside in the vacant octahedral locations within the alumina lattice, where complete conversion into the thermodynamically stable alpha-domain is shown in dysprosium (Dy)- and lutetium (Lu)-doped alumina. This study opens up the potential to control the structure and phase composition of Ln-doped alumina for emerging applications. C1 [Patel, Ketan; Dai, Qilin; Ren, Shenqiang] Temple Univ, Dept Mech Engn, Philadelphia, PA 19122 USA. [Patel, Ketan; Dai, Qilin; Ren, Shenqiang] Temple Univ, Temple Mat Inst, Philadelphia, PA 19122 USA. [Blair, Victoria; Brennan, Raymond] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Douglas, Justin] Univ Kansas, Mol Struct Grp, Lawrence, KS 66045 USA. [Liu, Yaohua] Oak Ridge Natl Lab, Quantum Condensed Matter Div, Oak Ridge, TN 37831 USA. RP Ren, SQ (reprint author), Temple Univ, Dept Mech Engn, Philadelphia, PA 19122 USA.; Ren, SQ (reprint author), Temple Univ, Temple Mat Inst, Philadelphia, PA 19122 USA.; Brennan, R (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM shenqiang.ren@temple.edu; raymond.e.brennan.civ@mail.mil RI Liu, Yaohua/B-2529-2009 OI Liu, Yaohua/0000-0002-5867-5065 FU Army Research Office; Army Research Laboratory [W911NF-15-1-0610]; U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]; Division of Scientific User Facilities of the Office of Basic Energy Sciences (BES), US Department of Energy (DOE); NSF Chemical Instrumentation Grant [0840515] FX Work at the Temple University (S.R.) was supported by the Army Research Office and Army Research Laboratory (W911NF-15-1-0610). Use of the Advanced Photon Source (11-BM) at Argonne National Laboratory was supported by the U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. Work at ORNL was supported by the Division of Scientific User Facilities of the Office of Basic Energy Sciences (BES), US Department of Energy (DOE). Support for the NMR instrumentation was provided NSF Chemical Instrumentation Grant #0840515. Use of the Advanced Photon Source at Argonne National Laboratory was supported by the U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. NR 38 TC 0 Z9 0 U1 5 U2 5 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JAN 6 PY 2017 VL 7 AR 39946 DI 10.1038/srep39946 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EG8MP UT WOS:000391311500001 PM 28059121 ER PT J AU Dinneen, SR Osgood, RM Greenslade, ME Deravi, LF AF Dinneen, Sean R. Osgood, Richard M., III Greenslade, Margaret E. Deravi, Leila F. TI Color Richness in Cephalopod Chromatophores Originating from High Refractive Index Biomolecules SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS LA English DT Article ID SQUID CHROMATOPHORES; MELANIN; PIGMENTATION AB Cephalopods are arguably one of the most photonically sophisticated marine animals, as they can rapidly adapt their dermal color and texture to their surroundings using both structural and pigmentary coloration. Their chromatophore organs facilitate this process, but the molecular mechanism potentiating color change is not well understood. We hypothesize that the pigments, which are localized within nanostructured granules in the chromatophore, enhance the scattering of light within the dermal tissue. To test this, we extracted the phenoxazone-based pigments from the chromatophore and extrapolated their complex refractive index (RI) from experimentally determined real and approximated imaginary portions of the RI. Mie theory was used to calculate the absorbance and scattering cross sections (cm(2)/particle) across a broad diameter range at lambda = 589 nm. We observed that the pigments were more likely to scatter attenuated light than absorb it and that these characteristics may contribute to the color richness of cephalopods. C1 [Dinneen, Sean R.; Greenslade, Margaret E.] Univ New Hampshire, Dept Chem, Durham, NH 03824 USA. [Osgood, Richard M., III] US Army, Natick Soldier Res Dev & Engn Ctr, Nanomat Team, Natick, MA 01760 USA. [Deravi, Leila F.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. RP Deravi, LF (reprint author), Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. EM l.deravi@northeastern.edu FU University of New Hampshire, Department of Chemistry; University of New Hampshire, College of Engineering and Physical Sciences; Center for Advanced Materials and Manufacturing Innovation; Army Research Office [W911NF-16-1-0455] FX We acknowledge Mr. Tyler Galpin for his assistance in the RI experiments. This work was supported by the University of New Hampshire, Department of Chemistry and College of Engineering and Physical Sciences (L.F.D., S.R.D., and M.E.G.), the Center for Advanced Materials and Manufacturing Innovation (L.F.D.), and the Army Research Office (W911NF-16-1-0455, L.F.D. and M.E.G.). NR 35 TC 0 Z9 0 U1 7 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7185 J9 J PHYS CHEM LETT JI J. Phys. Chem. Lett. PD JAN 5 PY 2017 VL 8 IS 1 BP 313 EP 317 DI 10.1021/acs.jpclett.6b02398 PG 5 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA EH3EJ UT WOS:000391653200047 PM 28009511 ER PT J AU Weightman, MM McCulloch, KL Radomski, MV Finkelstein, M Cecchini, AS Davidson, LF Heaton, KJ Smith, LB Scherer, MR AF Weightman, Margaret M. McCulloch, Karen L. Radomski, Mary V. Finkelstein, Marsha Cecchini, Amy S. Davidson, Leslie F. Heaton, Kristin J. Smith, Laurel B. Scherer, Matthew R. TI Further Development of the Assessment of Military Multitasking Performance: Iterative Reliability Testing SO PLOS ONE LA English DT Article ID MOBILITY ASSESSMENT-TOOL; TRAUMATIC BRAIN-INJURY; ECOLOGICAL VALIDITY; HIMAT; CONCUSSION; CHILDREN; VERSION AB The Assessment of Military Multitasking Performance (AMMP) is a battery of functional dual-tasks and multitasks based on military activities that target known sensorimotor, cognitive, and exertional vulnerabilities after concussion/mild traumatic brain injury (mTBI). The AMMP was developed to help address known limitations in post concussive return to duty assessment and decision making. Once validated, the AMMP is intended for use in combination with other metrics to inform duty-readiness decisions in Active Duty Service Members following concussion. This study used an iterative process of repeated interrater reliability testing and feasibility feedback to drive modifications to the 9 tasks of the original AMMP which resulted in a final version of 6 tasks with metrics that demonstrated clinically acceptable ICCs of > 0.92 (range of 0.92-1.0) for the 3 dual tasks and > 0.87 (range 0.87-1.0) for the metrics of the 3 multitasks. Three metrics involved in recording subject errors across 2 tasks did not achieve ICCs above 0.85 set apriori for multitasks (0.64) and above 0.90 set for dual-tasks (0.77 and 0.86) and were not used for further analysis. This iterative process involved 3 phases of testing with between 13 and 26 subjects, ages 18-42 years, tested in each phase from a combined cohort of healthy controls and Service Members with mTBI. Study findings support continued validation of this assessment tool to provide rehabilitation clinicians further return to duty assessment methods robust to ceiling effects with strong face validity to injured Warriors and their leaders. C1 [Weightman, Margaret M.; Radomski, Mary V.; Finkelstein, Marsha; Cecchini, Amy S.] Abbott NW Hosp, Courage Kenny Res Ctr, Minneapolis, MN 55407 USA. [McCulloch, Karen L.] Univ North Carolina Chapel Hill, Div Phys Therapy, Chapel Hill, NC USA. [Cecchini, Amy S.] Def & Vet Brain Injury Ctr, Ft Bragg, NC USA. [Davidson, Leslie F.] George Washington Sch Med & Hlth Sci, Dept Clin Res & Leadership, Washington, DC USA. [Heaton, Kristin J.; Smith, Laurel B.] US Army, Environm Med Res Inst, Natick, MA USA. [Heaton, Kristin J.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Scherer, Matthew R.] Med Res Mat Command, Clin & Rehabilitat Med Res Program, Ft Detrick, MD USA. RP Weightman, MM (reprint author), Abbott NW Hosp, Courage Kenny Res Ctr, Minneapolis, MN 55407 USA. EM margaret.weightman@allina.com FU US Army Medical Research and Materiel Command [W81XWH-12-2-0070] FX Funded by the US Army Medical Research and Materiel Command (award number W81XWH-12-2-0070); http://mrmc.amedd.army.mil/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 23 TC 0 Z9 0 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 5 PY 2017 VL 12 IS 1 AR e0169104 DI 10.1371/journal.pone.0169104 PG 19 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EH3AE UT WOS:000391639100021 PM 28056045 ER PT J AU Rajagopalan, M Darling, K Turnage, S Koju, RK Hornbuckle, B Mishin, Y Solanki, KN AF Rajagopalan, M. Darling, K. Turnage, S. Koju, R. K. Hornbuckle, B. Mishin, Y. Solanki, K. N. TI Microstructural evolution in a nanocrystalline Cu-Ta alloy: A combined in-situ TEM and atomistic study SO MATERIALS & DESIGN LA English DT Article DE In situ TEM; Nanocrystalline; Atomistic; Misfit strain ID CENTERED-CUBIC METALS; COPPER THIN-FILMS; GRAIN-GROWTH; MECHANICAL-PROPERTIES; DEFORMATION-BEHAVIOR; NANOSTRUCTURED CU; ALUMINUM; TEMPERATURE; STABILITY; CREEP AB Under intense heating and/or deformation, pure nanocrystalline (NC) metals exhibit significant grain coarsening, thus preventing the study of length scale effects on their physical response under such conditions. Hence, in this study, we use in-situ TEM heating experiments, atomistic modeling along with elevated temperature compression tests on a thermally stabilized nanostructured Cu-10 at.% Ta alloy to assess the microstructural manifestations caused by changes in temperature. Results reveal the thermal stability attained in NC Cu-10 at.% Ta diverges from those observed for conventional coarse-grained metals and other NC metals. Macroscopically, the microstructure, such as Cu grain and Ta based cluster size resists evolving with temperature. However, local structural changes at the interface between the Ta based clusters and the Cu matrix have a profound effect on thermo-mechanical properties. The lattice misfit between the Ta clusters and the matrix tends to decrease at high temperatures, promoting better coherency. In other words, the misfit strain was found to decrease monotonically from 12.9% to 4.0% with increase in temperature, leading to a significant change in flow stress, despite which (strength) remains greater than all known NC metals. Overall, the evolution of such fine structures is critical for developing NC alloys with exceptional thermo-mechanical properties. (C) 2016 Elsevier Ltd. All rights reserved. C1 [Rajagopalan, M.; Turnage, S.; Solanki, K. N.] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA. [Darling, K.; Hornbuckle, B.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21014 USA. [Koju, R. K.; Mishin, Y.] George Mason Univ, Dept Phys & Astron, MSN 3F3, Fairfax, VA 22030 USA. RP Solanki, KN (reprint author), Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA. EM kiran.solanki@asu.edu FU Army Research Laboratory [W911NF-15-2-0038]; U. S. Army Research Office [W911NF-15-1-007] FX M. Rajagopalan, S. Turnage, and K. N. Solanki are grateful for the financial support for this work from the Army Research Laboratory award number W911NF-15-2-0038 and would also like to thank the LeRoy Eyring Center for Solid State Science at Arizona State University. R. K. Koju and Y. Mishin were supported by the U. S. Army Research Office under contract number W911NF-15-1-007. NR 50 TC 0 Z9 0 U1 18 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-1275 EI 1873-4197 J9 MATER DESIGN JI Mater. Des. PD JAN 5 PY 2017 VL 113 BP 178 EP 185 DI 10.1016/j.matdes.2016.10.020 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA ED8TC UT WOS:000389142800021 ER PT J AU McAninch, IM La Scala, JJ Palmese, GR Robinette, EJ AF McAninch, Ian M. La Scala, John J. Palmese, Giuseppe R. Robinette, E. Jason TI Thin film initiation of cracks for fracture toughness measurements in epoxy resins SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE mechanical properties; properties and characterization; resins; thermosets ID MECHANISMS; BEHAVIOR AB The first step in accurately measuring the fracture toughness of a polymeric material is to generate a sharp crack in the sample. Often this is accomplished by tapping a razor blade into the sample, allowing a natural crack to grow; however, it can be difficult to control the crack propagation. Alternate methods for initial crack generation are investigated, including scoring the sample with a razor blade and inserting thin films or foils into the samples during cure. Fluoropolymer films and aluminum and stainless steel foils of various thicknesses are examined in a number of epoxy-amine resins with a range of toughness and glass transition values. None of the alternative methods replicate the results of starting with a natural crack. Furthermore, it is difficult to form satisfactory test samples using fluoropolymer films. For relative toughness comparisons, either the scoring method or thin, 25.4 m, foils can be used to initiate cracks with similar results. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44364. C1 [McAninch, Ian M.; La Scala, John J.; Robinette, E. Jason] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [McAninch, Ian M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, 3141 Chestnut St, Philadelphia, PA 19104 USA. RP Robinette, EJ (reprint author), Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM eric.j.robinette.civ@mail.mil OI McAninch, Ian/0000-0002-9190-2936 FU Postgraduate Research Participation Program at the U.S. Army Research Laboratory FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. NR 28 TC 0 Z9 0 U1 37 U2 37 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-8995 EI 1097-4628 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD JAN 5 PY 2017 VL 134 IS 1 AR 44364 DI 10.1002/app.44364 PG 15 WC Polymer Science SC Polymer Science GA DX8XD UT WOS:000384673900020 ER PT J AU Long, MC Brame, J Qin, F Bao, JM Li, QL Alvarez, PJJ AF Long, Mingce Brame, Jonathon Qin, Fan Bao, Jiming Li, Qilin Alvarez, Pedro J. J. TI Phosphate Changes Effect of Humic Acids on TiO2 Photocatalysis: From Inhibition to Mitigation of Electron-Hole Recombination SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID NATURAL ORGANIC-MATTER; WATER CONTAMINANTS; HYDROXYL RADICALS; AQUEOUS SUSPENSION; SINGLET OXYGEN; RATE CONSTANTS; DEGRADATION; OXIDATION; ADSORPTION; MECHANISM AB A major challenge for photocatalytic water purification with TiO2 is the strong inhibitory effect of natural organic matter (NOM), which can scavenge photogenerated holes and radicals and occlude ROS generation sites upon adsorption. This study shows that phosphate counteracts the inhibitory effect of humic acids (HA) by decreasing HA adsorption and mitigating electron-hole recombination. As a measure of the inhibitory effect of HA, the ratios of first-order reaction rate constants between photocatalytic phenol degradation in the absence versus presence of HA were calculated. This ratio was very high, up to 5.72 at 30 mg/L HA and pH 4.8 without phosphate, but was decreased to 0.76 (5 mg/L HA, pH 8.4) with 2 mM phosphate. The latter ratio indicates a surprising favorable effect of HA on TiO2 photocatalysis. FTIR analyses suggest that this favorable effect is likely due to a change in the conformation of adsorbed HA, from a multiligand exchange arrangement to a complexation predominantly between COOH groups in HA and the TiO2 surface in the presence of phosphate. This configuration can reduce hole consumption and facilitate electron transfer to O-2 by the adsorbed HA (indicated by linear sweep voltammetry), which mitigates electron hole recombination and enhances contaminant degradation. A decrease in HA surface adsorption and hole scavenging (the predominant inhibitory mechanisms of HA) by phosphate (2 mM) was indicated by a 50% decrease in the photocatalytic degradation rate of HA and 80% decrease in the decay rate coefficient of interfacial-related photooxidation in photocurrent transients. These results, which were validated with other compounds (FFA and cimetidine), indicate that anchoring phosphate or anions that exert similar effects on the TiO2 surface-might be a feasible strategy to counteract the inhibitory effect of NOM during photocatalytic water treatment. C1 [Long, Mingce] Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200240, Peoples R China. [Long, Mingce; Li, Qilin; Alvarez, Pedro J. J.] Rice Univ, Civil & Environm Engn, Houston, TX 77005 USA. [Qin, Fan; Bao, Jiming] Univ Houston, Dept Elect & Comp Engn, Houston, TX 77204 USA. [Brame, Jonathon] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Li, QL; Alvarez, PJJ (reprint author), Rice Univ, Civil & Environm Engn, Houston, TX 77005 USA. EM Qilin.Li@rice.edu; alvarez@rice.edu FU National Natural Science Foundation of China [21377084]; Shanghai Municipal International Cooperation Foundation [15230724600]; NSF ERC on Nanotechnology-Enabled Water Treatment [EEC-1449500] FX This work is financially supported by the National Natural Science Foundation of China (No. 21377084), Shanghai Municipal International Cooperation Foundation (No. 15230724600), and the NSF ERC on Nanotechnology-Enabled Water Treatment (EEC-1449500). NR 49 TC 0 Z9 0 U1 17 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 3 PY 2017 VL 51 IS 1 BP 514 EP 521 DI 10.1021/acs.est.6b04845 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA EG8ZR UT WOS:000391346900057 PM 27982576 ER PT J AU Slike, BM Creegan, M Marovich, M Ngauy, V AF Slike, Bonnie M. Creegan, Matthew Marovich, Mary Ngauy, Viseth TI Humoral Immunity to Primary Smallpox Vaccination: Impact of Childhood versus Adult Immunization on Vaccinia Vector Vaccine Development in Military Populations SO PLOS ONE LA English DT Article ID PREEXISTING POXVIRUS IMMUNITY; HIV-1 NEUTRALIZING ANTIBODIES; IMMUNOLOGICAL RESPONSE; HVTN 503/PHAMBILI; DENDRITIC CELLS; SOUTH-AFRICA; PHASE 2H; MVA-B; VIRUS; HIV/AIDS AB Modified Vaccinia virus has been shown to be a safe and immunogenic vector platform for delivery of HIV vaccines. Use of this vector is of particular importance to the military, with the implementation of a large scale smallpox vaccination campaign in 2002 in active duty and key civilian personnel in response to potential bioterrorist activities. Humoral immunity to smallpox vaccination was previously shown to be long lasting (up to 75 years) and protective. However, using vaccinia-vectored vaccine delivery for other diseases on a background of anti-vector antibodies (i.e. pre-existing immunity) may limit their use as a vaccine platform, especially in the military. In this pilot study, we examined the durability of vaccinia antibody responses in adult primary vaccinees in a healthy military population using a standard ELISA assay and a novel dendritic cell neutralization assay. We found binding and neutralizing antibody (NAb) responses to vaccinia waned after 5-10 years in a group of 475 active duty military, born after 1972, who were vaccinated as adults with Dryvax (R). These responses decreased from a geometric mean titer (GMT) of 250 to baseline (<20) after 1020 years post vaccination. This contrasted with a comparator group of adults, ages 35-49, who were vaccinated with Dryvax (R) as children. In the childhood vaccinees, titers persisted for >30 years with a GMT of 210 (range 112-3234). This data suggests limited durability of antibody responses in adult vaccinees compared to those vaccinated in childhood and further that adult vaccinia recipients may benefit similarly from receipt of a vaccinia based vaccine as those who are vaccinia na ve. Our findings may have implications for the smallpox vaccination schedule and support the ongoing development of this promising viral vector in a military vaccination program. C1 [Slike, Bonnie M.; Creegan, Matthew] US Mil HIV Res Program, Silver Spring, MD USA. [Slike, Bonnie M.; Creegan, Matthew] Henry M Jackson Adv Mil Med, Bethesda, MD USA. [Marovich, Mary] NIAID, Div Aids, Bethesda, MD USA. [Ngauy, Viseth] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Ngauy, V (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. EM Viseth.ngauy.mil@mail.mil FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067]; Infectious Disease Clinical Research Program (IDCRP); Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072]; Military Vaccine Program (MILVAX) FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. and the U.S. Department of Defense, the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072, and the Military Vaccine Program (MILVAX). The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Army or DoD. NR 34 TC 0 Z9 0 U1 2 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 3 PY 2017 VL 12 IS 1 AR e0169247 DI 10.1371/journal.pone.0169247 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EH2QJ UT WOS:000391612300152 PM 28046039 ER PT J AU Reddy, P Sarkar, B Kaess, F Gerhold, M Kohn, E Collazo, R Sitar, Z AF Reddy, Pramod Sarkar, Biplab Kaess, Felix Gerhold, Michael Kohn, Erhard Collazo, Ramon Sitar, Zlatko TI Defect-free Ni/GaN Schottky barrier behavior with high temperature stability SO APPLIED PHYSICS LETTERS LA English DT Article ID CONTACTS; DIODES; GAN AB In this work, we report on defect-free homogeneous behavior of Ni Schottky contacts patterned on surface treated n-GaN by photolithography with unity ideality factor, high temperature stability, and low reverse leakage. The barrier height (0.7 eV) and ideality factor (1.02) are found to be independent of temperature, indicating a highly homogeneous contact. The contacts are found to be stable with no significant change in ideality factor or leakage current up to an annealing temperature of 600 degrees C. Temperature dependence of the reverse leakage current shows no evidence for the existence of surface defects that would provide leakage paths, and the behavior was modeled by ATLAS simulations with an ideal homogeneous barrier of 0.7 eV. Consequently, the forward and reverse bias characteristics are explained by a common set of parameters. The surface treatment after the development and prior to metallization included an acid-based surface treatment. X-ray photoelectron spectroscopy (XPS) studies indicate that the hydroxide-based development process during photolithography changes the nitride surface composition by introducing excess C that degrades the ideality factor and introduces barrier inhomogeneity and high leakage currents. XPS studies further demonstrate that the restoration of a stable, Ga-rich surface, similar to as-grown surface, occurs due to the acid-based surface treatment, which is responsible for the observed unity ideality factor, homogeneous barrier, low leakage current, and high temperature stability. C1 [Reddy, Pramod; Sarkar, Biplab; Kaess, Felix; Kohn, Erhard; Collazo, Ramon; Sitar, Zlatko] North Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. [Reddy, Pramod; Sitar, Zlatko] Adroit Mat Inc, 2054 Kildaire Farm Rd,Suite 205, Cary, NC 27518 USA. [Gerhold, Michael] Army Res Off, Engn Sci Directorate, POB 12211, Res Triangle Pk, NC 27703 USA. RP Reddy, P (reprint author), North Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA.; Reddy, P (reprint author), Adroit Mat Inc, 2054 Kildaire Farm Rd,Suite 205, Cary, NC 27518 USA. OI Reddy, Pramod/0000-0002-8556-1178 FU NSF [DMR-1312582, ECCS-1508854, ECCS-1610992, DMR-1508191]; ARO [W911NF-15-2-0068, W911NF-16-C-0101]; National Science Foundation as part of the National Nanotechnology Coordinated Infrastructure (NNCI) [ECCS-1542015] FX Partial financial support from NSF (DMR-1312582, ECCS-1508854, ECCS-1610992, and DMR-1508191), ARO (W911NF-15-2-0068 and W911NF-16-C-0101). This work was performed in part at the NCSU Nanofabrication Facility (NNF), a member of the North Carolina Research Triangle Nanotechnology Network (RTNN), which is supported by the National Science Foundation (Grant No. ECCS-1542015) as part of the National Nanotechnology Coordinated Infrastructure (NNCI). ATLAS simulations were performed using SILVACO. NR 18 TC 0 Z9 0 U1 3 U2 3 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 2 PY 2017 VL 110 IS 1 AR 011603 DI 10.1063/1.4973762 PG 5 WC Physics, Applied SC Physics GA EI9NI UT WOS:000392834600011 ER PT B AU Smith, LB Wheeler, PC Vigilante, GN AF Smith, Lucas B. Wheeler, Philip C. Vigilante, Gregory N. BE Karpanan, K Gross, DJ Mohanty, S Nitzel, ME TI METHOD FOR DEVELOPING VARIABLE AXIAL LOADING IN THICK WALLED PRESSURE VESSELS SO PROCEEDINGS OF THE ASME PRESSURE VESSELS AND PIPING CONFERENCE, 2016, VOL 5 LA English DT Proceedings Paper CT ASME Pressure Vessels and Piping Conference CY JUL 17-21, 2016 CL Vancouver, CANADA SP ASME, Pressure Vessels & Pip Div AB Traditional hydraulic fatigue testing is performed on open ended cylindrical sections of pressure vessels to establish their fatigue life. Typically only hoop loading of the pressure vessels is required to determine fatigue life. However, for some specific geometries and service conditions a more complex test is required. It has been confirmed that certain geometries have experienced circumferential cracking because of combined, nearly equivalent axial loading and hoop loading. Consequently, a test fixture was engineered, designed, built and tested by US Army - Benet Laboratories / ARDEC to replicate the service loading condition. Simultaneous axial / hoop fatigue testing results in a more realistic representation of service loading conditions and a more accurate determination of fatigue life for these non-typical cases. C1 [Smith, Lucas B.; Wheeler, Philip C.; Vigilante, Gregory N.] US Army, Benet Labs, Watervliet, NY USA. RP Smith, LB (reprint author), US Army, Benet Labs, Watervliet, NY USA. EM lucas.b.smith.civ@mail.mil; philip.c.wheeler4.civ@mail.mil; gregory.n.vigilante.civ@mail.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5041-1 PY 2017 AR UNSP V005T05A014 PG 6 WC Engineering, Mechanical SC Engineering GA BH0YP UT WOS:000397071600014 ER PT S AU Cardile, AP Warren, TK Martins, KA Reisler, RB Bavari, S AF Cardile, Anthony P. Warren, Travis K. Martins, Karen A. Reisler, Ronald B. Bavari, Sina BE Insel, PA TI Will There Be a Cure for Ebola? SO ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 57 SE Annual Review of Pharmacology and Toxicology LA English DT Review; Book Chapter DE BCX4430; brincidofovir; favipiravir; GS-5734; ZMapp; convalescent plasma ID IN-VIVO ACTIVITIES; VIRUS DISEASE; NONHUMAN-PRIMATES; HEMORRHAGIC-FEVER; RNA INTERFERENCE; FAVIPIRAVIR T-705; POSTEXPOSURE PROTECTION; FILOVIRUS INFECTIONS; CONVALESCENT PLASMA; ANTIVIRAL ACTIVITY AB Despite the unprecedented Ebola virus outbreak response in West Africa, no Ebola medical countermeasures have been approved by the US Food and Drug Administration. However, multiple valuable lessons have been learned about the conduct of clinical research in a resource-poor, high risk-pathogen setting. Numerous therapeutics were explored or developed during the outbreak, including repurposed drugs, nucleoside and nucleotide analogues (BCX4430, brincidofovir, favipiravir, and GS-5734), nucleic acid-based drugs (TKM-Ebola and AVI-7537), and immunotherapeutics (convalescent plasma and ZMapp). We review Ebola therapeutics progress in the aftermath of the West Africa Ebola virus outbreak and attempt to offer a glimpse of a path forward. C1 [Cardile, Anthony P.; Warren, Travis K.; Martins, Karen A.; Reisler, Ronald B.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Cardile, AP (reprint author), US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM anthony.p.cardile.mil@mail.mil NR 99 TC 0 Z9 0 U1 0 U2 0 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA SN 0362-1642 BN 978-0-8243-0457-7 J9 ANNU REV PHARMACOL JI Annu. Rev. Pharmacol. Toxicol. PY 2017 VL 57 BP 329 EP 348 DI 10.1146/annurev-pharmtox-010716-105055 PG 20 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA BH0QN UT WOS:000396044800017 PM 27959624 ER PT J AU Kahn, AE Mattar, MG Vettel, JM Wymbs, NF Grafton, ST Bassett, DS AF Kahn, Ari E. Mattar, Marcelo G. Vettel, Jean M. Wymbs, Nicholas F. Grafton, Scott T. Bassett, Danielle S. TI Structural Pathways Supporting Swift Acquisition of New Visuomotor Skills SO CEREBRAL CORTEX LA English DT Article DE diffusion MRI; discrete sequence production; graph theory; motor sequence learning; polysynaptic networks ID POSTERIOR PARIETAL CORTEX; WHITE-MATTER PATHWAYS; FUNCTIONAL CONNECTIVITY; HUMAN BRAIN; RESTING-STATE; REFERENCE FRAMES; DIFFUSION MRI; REACTION-TIME; LIFE-SPAN; MOTOR AB Human skill learning requires fine-scale coordination of distributed networks of brain regions linked by white matter tracts to allow for effective information transmission. Yet how individual differences in these anatomical pathways may impact individual differences in learning remains far from understood. Here, we test the hypothesis that individual differences in structural organization of networks supporting task performance predict individual differences in the rate at which humans learn a visuomotor skill. Over the course of 6 weeks, 20 healthy adult subjects practiced a discrete sequence production task, learning a sequence of finger movements based on discrete visual cues. We collected structural imaging data, and using deterministic tractography generated structural networks for each participant to identify streamlines connecting cortical and subcortical brain regions. We observed that increased white matter connectivity linking early visual regions was associated with a faster learning rate. Moreover, the strength of multiedge paths between motor and visual modules was also correlated with learning rate, supporting the potential role of extended sets of polysynaptic connections in successful skill acquisition. Our results demonstrate that estimates of anatomical connectivity from white matter microstructure can be used to predict future individual differences in the capacity to learn a new motor-visual skill, and that these predictions are supported both by direct connectivity in visual cortex and indirect connectivity between visual cortex and motor cortex. C1 [Kahn, Ari E.] Univ Penn, Dept Neurosci, Philadelphia, PA 19104 USA. [Kahn, Ari E.; Vettel, Jean M.; Bassett, Danielle S.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA. [Kahn, Ari E.; Vettel, Jean M.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen, MD 21001 USA. [Mattar, Marcelo G.] Univ Penn, Dept Psychol, 3815 Walnut St, Philadelphia, PA 19104 USA. [Vettel, Jean M.; Grafton, Scott T.] Univ Calif Santa Barbara, Dept Psychol & Brain Sci, Santa Barbara, CA 93106 USA. [Wymbs, Nicholas F.] Johns Hopkins Univ, Dept Phys Med & Rehabil, Baltimore, MD 21218 USA. [Bassett, Danielle S.] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA. RP Bassett, DS (reprint author), Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA.; Bassett, DS (reprint author), Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA. EM dsb@seas.upenn.edu FU John D. and Catherine T. MacArthur Foundation; Alfred P. Sloan Foundation; Army Research Laboratory; Army Research Office [W911NF-10-2-0022, W911NF-14-1-0679]; National Institute of Mental Health [2-R01-DC-009209-11]; National Institute of Child Health and Human Development [1R01HD086888-01]; Office of Naval Research; National Science Foundation [BCS-1441502, BCS-1430087, PHY-1554488]; National Institute of Neurologic Disease and Stroke [1-P01-NS44393] FX D.S.B. and A.K. acknowledge support from the John D. and Catherine T. MacArthur Foundation, the Alfred P. Sloan Foundation, the Army Research Laboratory and the Army Research Office through contract numbers W911NF-10-2-0022 and W911NF-14-1-0679, the National Institute of Mental Health (2-R01-DC-009209-11), the National Institute of Child Health and Human Development (1R01HD086888-01), the Office of Naval Research, and the National Science Foundation (BCS-1441502, BCS-1430087, and PHY-1554488). S.T.G. and N.F.W. acknowledge support from the National Institute of Neurologic Disease and Stroke (1-P01-NS44393). NR 90 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1047-3211 EI 1460-2199 J9 CEREB CORTEX JI Cereb. Cortex PD JAN PY 2017 VL 27 IS 1 BP 173 EP 184 DI 10.1093/cercor/bhw335 PG 12 WC Neurosciences SC Neurosciences & Neurology GA EP0GI UT WOS:000397064800015 PM 27920096 ER PT J AU Schuldenrein, J Trimble, MK Malin-Boyce, S Smith, M AF Schuldenrein, Joseph Trimble, Michael K. Malin-Boyce, Susan Smith, Mark TI Geoarchaeology, Forensics, and the Prosecution of Saddam Hussein: A Case Study from the Iraq War (2003-2011) SO GEOARCHAEOLOGY-AN INTERNATIONAL JOURNAL LA English DT Article ID BASIN AB During the Iraq War (2003-2011), the U.S. government dispatched teams of forensic archaeologists and anthropologists to examine a series of mass graves, a site of genocide allegedly perpetrated by Saddam Hussein in the late 20th century. Remote sensing and limited field-testing disclosed a crime scene featuring extensive landscape disturbances from haphazard placements of shallow, presumed grave trenches and associated spoil heaps. Geoarchaeological expertise was used to explain the terrain irregularities at the crime scene and to reconstruct the processes and sequence chronology of grave site selection, interments, and site abandonment. Geomorphic investigations included observations of field relations and follow-up sedimentological and geochemical analyses. The precrime scene landforms were demonstrably Upper Pleistocene in age and were underlain by calcretes of variable morphogenetic origins; they produced an impenetrable crust of variable depths. Misreading of these elements underpinned the flawed planning and inefficient excavation and disposal strategies by the perpetrators. Geochemical analysis of the grave fills isolated elements (chiefly K) that could be diagnostic of otherwise homogeneous sediment units. Taken together, these data provided key evidence for conviction of the Hussein regime. A "geotaphonomic model" for mass graves analysis is proposed as a blueprint for practical and critical future applications of geoarchaeology. (C) 2016 Wiley Periodicals, Inc. C1 [Schuldenrein, Joseph] Geoarcheol Res Associates, Yonkers, NY 10701 USA. [Trimble, Michael K.; Malin-Boyce, Susan; Smith, Mark] US Army Corps Engineers, Mandatory Ctr Expertise Archaeol Curat & Collect, St Louis, MO USA. RP Schuldenrein, J (reprint author), Geoarcheol Res Associates, Yonkers, NY 10701 USA. EM joseph.schuldenrein@gra-geoarch.com FU U.S. Army Corps of Engineers (St. Louis) FX The authors undertook this work on behalf and under the auspices of the U.S. Army Corps of Engineers (St. Louis). They provided the opportunity and resources for the project effort. The initiative for the Mass Graves investigations was provided by the U.S. Department of Justice and the Regime Crimes Liaison Office, United States Embassy, Baghdad, Iraq. Laboratory work and soil-sediment analyses were performed under the direction of Dr. Andrew Ivester and Randa Harris at the laboratories of the University of West Georgia. The manuscript was improved by the thoughtful comments and inputs of two anonymous reviewers. We thank Dr. Zenobie Garrett who offered key editorial input at the latter stages of review. Any and all shortcomings are purely the responsibility of the authors. Finally, the senior author is eternally grateful to the late Dr. Karl W. Butzer whose seminal constructs of the human ecological dynamic expanded the reach of geoarchaeology in ways that none of us could have imagined. NR 46 TC 0 Z9 0 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0883-6353 EI 1520-6548 J9 GEOARCHAEOLOGY JI Geoarchaeology PD JAN-FEB PY 2017 VL 32 IS 1 SI SI BP 130 EP 156 DI 10.1002/gea.21586 PG 27 WC Archaeology; Geosciences, Multidisciplinary SC Archaeology; Geology GA EO1LC UT WOS:000396459000008 ER PT J AU Pappu, CS Flores, BC Debroux, PS Verdin, B Boehm, J AF Pappu, Chandra Sekhar Flores, Benjamin C. Debroux, Patrick S. Verdin, Berenice Boehm, James TI Synchronisation of bistatic radar using chaotic AM and chaos-based FM waveforms SO IET RADAR SONAR AND NAVIGATION LA English DT Article ID PROJECTIVE SYNCHRONIZATION; SYSTEMS; SIGNALS AB The authors developed a technique to synchronise a bistatic radar that uses a chaotic system to generate and process either wideband amplitude modulated (AM) or frequency modulated (FM) waveforms thereby extracting high-resolution information from the targets. For chaotic AM bistatic radar, a generalised projective synchronisation approach that includes a driving oscillator at the transmitter and a response oscillator at the receiver is considered. The receiver accepts a scaled version of the transmitted waveform where the scaling factor a accounts for space propagation losses that may not be known a priori. However, AM synchronisation is highly susceptible to noise. Alternatively, FM bistatic radar is implemented with a chaos-based FM waveform. Demodulation of this waveform using a phase lock loop is required to recover the instantaneous frequency which represents a chaotic state variable. The recovered and transmitter instantaneous frequencies are synchronised by using either generalised projective synchronisation or complete replacement synchronisation. The synchronised output is then used to reconstruct the FM waveform. They show that the short-time cross-correlation of the transmitted and reconstructed waveforms is high and its self-noise is negligible. Through entropy analysis of the cross-correlogram, they found that the bistatic FM radar performs better than the bistatic AM radar. C1 [Pappu, Chandra Sekhar; Flores, Benjamin C.] Univ Texas, Elect & Comp Engn Dept, 500W Univ Ave, El Paso, TX 79902 USA. [Debroux, Patrick S.; Verdin, Berenice; Boehm, James] Army Res Lab, Survivabil Lethal Anal Directorate, White Sands Missile Range, White Sands Missile Range, NM USA. RP Pappu, CS (reprint author), Univ Texas, Elect & Comp Engn Dept, 500W Univ Ave, El Paso, TX 79902 USA. EM cspappu@miners.utep.edu NR 34 TC 0 Z9 0 U1 1 U2 1 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8784 EI 1751-8792 J9 IET RADAR SONAR NAV JI IET Radar Sonar Navig. PD JAN PY 2017 VL 11 IS 1 BP 90 EP 97 DI 10.1049/iet-rsn.2016.0043 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA EO1DO UT WOS:000396438100011 ER PT J AU Wong, B Perkins, MW Tressler, J Rodriguez, A Devorak, J Sciuto, AM AF Wong, Benjamin Perkins, Michael W. Tressler, Justin Rodriguez, Ashley Devorak, Jennifer Sciuto, Alfred M. TI Effects of inhaled aerosolized carfentanil on real-time physiological responses in mice: a preliminary evaluation of naloxone SO INHALATION TOXICOLOGY LA English DT Article DE Cardiac function; carfentanil; inhalation exposure; naloxone; respiratory dynamics; respiratory toxicology ID INDUCED RESPIRATORY DEPRESSION; CERVUS-ELAPHUS-NELSONI; OPIOID ANALGESICS; DOMESTIC GOATS; IMMOBILIZATION; RAT; NALTREXONE; ETORPHINE; RECEPTORS; MECHANISM AB This study examined the real-time exposure-response effects of aerosolized carfentanil (CRF) on opioid- induced toxicity, respiratory dynamics and cardiac function in mice. Unrestrained, conscious male CD-1 mice (25-30 g) were exposed to 0.4 or 4.0mg/m(3) of aerosolized CRF for 15 min (Ct = 6 or 60mgmin/m(3)) in a whole-body plethysmograph chamber. Minute volume (MV), core body temperature (Tc), mean arterial blood pressure (MAP) and heart rate (HR) were evaluated in animals exposed to CRF or sterile H2O. Loss of consciousness and Straub tail were observed in before 1 min following initiation of exposure to 6 or 60mg min/m(3) of CRF. Clinical signs of opioid-induced toxicity were observed in a dose-dependent manner. Exposure to 6 or 60mg min/m3 of CRF resulted in significant decrease in MV as compared to the controls. MAP, HR and Tc decreased 24 h in animals exposed to either 6 or 60mgmin/m(3) of CRF as compared to the controls. Post-exposure administration of naloxone (NX, 0.05 mg/kg,i.m.) did not increase the MV of animals exposed to CRF to control levels within 24 h, but decreased clinical signs of opioid-induced toxicity and the duration of respiratory depression. This is the first study to evaluate real-time respiratory dynamics and cardiac function during exposure and up to 24 h post-exposure to CRF. The evaluation of toxicological signs and respiratory dynamics following exposure to CRF will be useful in the development of therapeutic strategies to counteract the ongoing threat of abuse and overuse of opioids and their synthetic variants. C1 [Wong, Benjamin; Perkins, Michael W.; Tressler, Justin; Rodriguez, Ashley; Devorak, Jennifer; Sciuto, Alfred M.] US Army Med Res Inst Chem Def, Biochem & Toxicol Branch, Aberdeen Proving Ground, MD USA. RP Wong, B (reprint author), US Army Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM benjamin.j.wong.civ@mail.mil FU Defense Threat Reduction Agency FX This work was supported by the Defense Threat Reduction Agency. NR 48 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PY 2017 VL 29 IS 2 BP 65 EP 74 DI 10.1080/08958378.2017.1282065 PG 10 WC Toxicology SC Toxicology GA EP5GQ UT WOS:000397407400004 PM 28330429 ER PT J AU Spracher, WC AF Spracher, William C. TI National Intelligence University: a half century educating the next generation of U.S. Intelligence Community Leaders SO INTELLIGENCE AND NATIONAL SECURITY LA English DT Article AB Founded in 1962, the National Intelligence University has evolved over more than five decades into living up to its current vision as 'The Center of Academic Life for the Intelligence Community.' With the intelligence reforms post-9/11 and the development of the NIU concept, the mission has changed from a military-centric focus of instruction to educating a more diverse audience from throughout the IC, both military and civilian, fulltime and part-time, active and Reserves, with an emphasis on taking higher education to an interagency clientele spread globally and desiring different learning outcomes. The result is a rapid growth in offsite academic centers and a resurgence of certificate programs geared to professionals who already have a degree but wish to enhance their credentials in intelligence specialty fields. There is also an effort to revive concentrations and programs of study. This article outlines the steps NIU is taking to make itself more flexible and marketable to a growing and demanding academic audience that is much more than the uniformed DoD students who matriculated in the past with full-time resident study as their only option. C1 [Spracher, William C.] Natl Intelligence Univ, Washington, DC 20301 USA. [Spracher, William C.] Natl Def Univ, Ctr Hemispher Def Studies, Washington, DC USA. [Spracher, William C.] US Mil Acad, Dept Teach Polit Sci Comparat Polit & Intelligenc, West Point, NY USA. [Spracher, William C.] Joint Mil Intelligence Coll, Washington, DC USA. [Spracher, William C.] Amer Univ, Sch Int Serv, Washington, DC 20016 USA. RP Spracher, WC (reprint author), Natl Intelligence Univ, Washington, DC 20301 USA. EM william.spracher@dodiis.mil NR 20 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0268-4527 EI 1743-9019 J9 INTELL NATL SECUR JI Intell. Natl. Secur. PY 2017 VL 32 IS 2 BP 231 EP 243 DI 10.1080/02684527.2016.1248316 PG 13 WC International Relations SC International Relations GA EO7GE UT WOS:000396858400009 ER PT J AU Fitzgerald, CW Brantly, AF AF Fitzgerald, Chad W. Brantly, Aaron F. TI Subverting Reality: The Role of Propaganda in 21st Century Intelligence SO INTERNATIONAL JOURNAL OF INTELLIGENCE AND COUNTERINTELLIGENCE LA English DT Article AB The digital era has placed most of humanity's knowledge within a few clicks of a computer mouse or the touches of a smart phone screen. Yet in an age where knowledge is so readily available it is also seemingly elusive. Reality hides behind oceans of information streamed from innumerable sources competing for a single moment of attention. But disinformation dangerously poisons that abundance of knowledge and begins a process of ideational inception, in which even the idea of reality is itself subverted. C1 [Fitzgerald, Chad W.] United States Mil Acad, Dept Social Sci, Int Relat, West Point, NY USA. RP Fitzgerald, CW (reprint author), United States Mil Acad, Dept Social Sci, Int Relat, West Point, NY USA. NR 54 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0885-0607 EI 1521-0561 J9 INT J INTELL COUNTER JI Int. J. Intell. Counterintelligence PY 2017 VL 30 IS 2 BP 215 EP 240 DI 10.1080/08850607.2017.1263528 PG 26 WC International Relations SC International Relations GA EO3KR UT WOS:000396594100001 ER PT J AU Lettieri, CJ Williams, SG AF Lettieri, Christopher J. Williams, Scott G. TI The PTSD-OSA Paradox: They Are Commonly Associated and They Worsen Outcomes, but Treatment Nonadherence Is Common and the Therapeutic Effect Limited. What Are Clinicians To Do? SO JOURNAL OF CLINICAL SLEEP MEDICINE LA English DT Editorial Material ID POSTTRAUMATIC-STRESS-DISORDER; OBSTRUCTIVE SLEEP-APNEA; IMPACT C1 [Lettieri, Christopher J.; Williams, Scott G.] Walter Reed Natl Mil Med Ctr, Pulm Crit Care & Sleep Med, Bethesda, MD USA. RP Lettieri, CJ (reprint author), Walter Reed Army Med Ctr, Bethesda, MD 20889 USA. EM christopher.lettieri.mil@mail.mil NR 11 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI DARIEN PA 2510 N FRONTAGE RD, DARIEN, IL 60561 USA SN 1550-9389 EI 1550-9397 J9 J CLIN SLEEP MED JI J. Clin. Sleep Med. PY 2017 VL 13 IS 1 BP 5 EP 6 AR PII jc-00487-16 DI 10.5664/jcsm.6370 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA EL2RV UT WOS:000394468000001 PM 27998382 ER PT J AU Knight, DB Novoselich, BJ AF Knight, David B. Novoselich, Brian J. TI Curricular and Co-curricular Influences on Undergraduate Engineering Student Leadership SO JOURNAL OF ENGINEERING EDUCATION LA English DT Article DE leadership; student experience; quantitative; engineering curriculum; co-curricular ID MISSING DATA; REAL-WORLD; 1ST YEAR; EDUCATION; COLLEGE; METAANALYSIS; PERSONALITY; COMPETENCE; INSTRUMENT; IDENTITY AB Background Multiple reports call for undergraduate programs to develop engineers who have leadership abilities. Such preparation requires understanding how the undergraduate experience relates to student leadership abilities. Limited research has shown disagreement among faculty members and administrators about effective approaches for engineering leadership development. Purpose/Hypothesis The purpose of this research was to understand what precollege characteristics and experiences, university experiences, and undergraduate engineering program contexts relate to undergraduate engineers' self-reported leadership skills. Design/Methods Using hierarchical linear modeling, this quantitative study examined the variance of students' self-reported leadership skills as explained by their precollege characteristics and undergraduate experiences. The study drew from a nationally representative survey-based dataset of 5,076 undergraduate engineers from 150 undergraduate engineering programs from 31 colleges and universities. Results Although multiple facets of the undergraduate experience significantly relate to students' self-reported leadership skills, curricular emphases on core engineering thinking, professional skills, and broad and systems perspectives explain the greatest amount of variance. The lack of significant relationships at the program level suggests a lack of formal leadership development within the undergraduate curriculum at large. Conclusions Results indicate that entrusting the leadership development of undergraduate engineering students to the co-curriculum is an inefficient method of developing leadership skills for undergraduate engineers. The curriculum more strongly relates to engineering students' leadership skills. Identifying ways for faculty members to enhance this curricular focus could further development of technologically adept engineering leaders. C1 [Knight, David B.] Virginia Tech, Int Engagement Engn Educ, 369 Goodwin Hall,635 Prices Fork Rd, Blacksburg, VA 24061 USA. [Novoselich, Brian J.] US Mil Acad, Mech Engn, Bldg 752 Thayer Rd, West Point, NY 10996 USA. RP Knight, DB (reprint author), Virginia Tech, Int Engagement Engn Educ, 369 Goodwin Hall,635 Prices Fork Rd, Blacksburg, VA 24061 USA. EM dbknight@vt.edu; brian.novoselich@usma.edu FU National Science Foundation [EEC0550608] FX This study was supported by a grant from the National Science Foundation (grant EEC0550608). The opinions expressed here do not reflect the opinions or policies of the NSF, and no official endorsement should be inferred. The authors wish to acknowledge the contributions of the members of the NSF project team who participated in various stages of the development of the design, instruments, and databases used in this article: Patrick T. Terenzini, Lisa R. Lattuca, Betty J. Harper, Alexander C. Yin, Hyun Kyoung Ro, Gul Kremer, Thomas A. Litzinger, India McHale, David C. Perez II, DanielMerson, and Travis York. NR 90 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N ST, N W, STE 600, WASHINGTON, DC 20036 USA SN 1069-4730 EI 2168-9830 J9 J ENG EDUC JI J. Eng. Educ. PD JAN PY 2017 VL 106 IS 1 BP 44 EP 70 DI 10.1002/jee.20153 PG 27 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA EO1RJ UT WOS:000396475300004 ER PT J AU Lattuca, LR Knight, DB Ro, HK Novoselich, BJ AF Lattuca, Lisa R. Knight, David B. Ro, Hyun Kyoung Novoselich, Brian J. TI Supporting the Development of Engineers' Interdisciplinary Competence SO JOURNAL OF ENGINEERING EDUCATION LA English DT Article DE interdisciplinary; curriculum; extracurricular; faculty attitudes; undergraduate ID SURVEY RESPONSE RATES; SELF-EFFICACY; MISSING DATA; REAL-WORLD; STUDENTS; WORKING; CHOICE; TEAMS AB Background Although interdisciplinarity has been a subject of interest and debate for decades, few investigations of interdisciplinary education exist. Existing studies examine the effects of interdisciplinary experiences on students' development of generic cognitive skills but not the development of interdisciplinary competencies. Purpose/Hypothesis This study sought to explore how engineering students' characteristics, college experiences, and engineering faculty beliefs relate to students' reports of interdisciplinary competence. Design/Method The study used a nationally representative survey sample of 5,018 undergraduate students and 1,119 faculty members in 120 U.S. engineering programs at 31 institutions. Using hierarchical linear modeling, we investigated the relationships among students' curricular and co-curricular experiences and faculty beliefs regarding interdisciplinarity in engineering education on students' reports of interdisciplinary competence. Results This study found that a curricular emphasis on interdisciplinary topics and skills, as well as co-curricular activities, specifically, participating in nonengineering clubs and organizations, study abroad, and humanitarian engineering projects, significantly and positively relate to engineering students' reports of interdisciplinary skills. Faculty members' beliefs regarding interdisciplinarity in engineering education moderated the relationships between particular co-curricular experiences and students' interdisciplinary skills, as well as between curricular emphasis and students' interdisciplinary skills. Conclusions This study identified a small set of experiences that are related to students' reported development of interdisciplinary competence. The study points to the critical role of the curriculum in promoting interdisciplinary thinking and habits of mind, as well as the potential of co-curricular opportunities that bring engineering students together with non-majors to build interdisciplinary competence. C1 [Lattuca, Lisa R.] Univ Michigan, Higher Educ & Integrat Syst & Design, 610 Univ Ave, Ann Arbor, MI 48109 USA. [Knight, David B.] Virginia Tech, Engn Educ, 614 McBryde Hall,225 Stanger St, Blacksburg, VA 24061 USA. [Ro, Hyun Kyoung] Bowling Green State Univ, Higher Educ, Bowling Green, OH 43403 USA. [Novoselich, Brian J.] US Mil Acad, Civil & Mech Engn, Bldg 752 Thayer Rd, West Point, NY 10996 USA. RP Lattuca, LR (reprint author), Univ Michigan, Higher Educ & Integrat Syst & Design, 610 Univ Ave, Ann Arbor, MI 48109 USA. EM llatt@umich.edu; davidknight@vt.edu; hro@bgsu.edu; brian.novoselich@usma.edu FU National Science Foundation [EEC-0550608] FX A grant from the National Science Foundation (EEC-0550608) supported this study. Opinions expressed herein are those of the authors, and no endorsement by the National Science Foundation should be inferred. This article substantially extends Lattuca, Knight, Ro, & Novoselich (2014). NR 67 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N ST, N W, STE 600, WASHINGTON, DC 20036 USA SN 1069-4730 EI 2168-9830 J9 J ENG EDUC JI J. Eng. Educ. PD JAN PY 2017 VL 106 IS 1 BP 71 EP 97 DI 10.1002/jee.20155 PG 27 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA EO1RJ UT WOS:000396475300005 ER PT J AU Ottichilo, RK Polyak, CS Guyah, B Singa, B Nyataya, J Yuhas, K John-Stewart, G Waitumbi, JN AF Ottichilo, Ronald K. Polyak, Christina S. Guyah, Bernard Singa, Benson Nyataya, Josphat Yuhas, Krista John-Stewart, Grace Waitumbi, John N. TI Malaria Parasitemia and Parasite Density in Antiretroviral-Treated HIV-Infected Adults Following Discontinuation of Cotrimoxazole Prophylaxis SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE HIV; malaria; cotrimoxazole; parasitemia; antiretroviral treatment; adults ID TRIMETHOPRIM-SULFAMETHOXAZOLE; DIHYDROPTEROATE SYNTHASE; STREPTOCOCCUS-PNEUMONIAE; DIHYDROFOLATE-REDUCTASE; HIV-1-INFECTED ADULTS; COTE-DIVOIRE; PLASMODIUM; FALCIPARUM; RESISTANCE; UGANDA AB Background. Cotrimoxazole (CTX) discontinuation increases malaria incidence in human immunodeficiency virus (HIV)-infected individuals. Rates, quantity, and timing of parasitemia rebound following CTX remain undefined. Methods. Serial specimens from a trial of HIV-infected individuals receiving antiretroviral treatment (ART) randomized to continue (the CTX arm) or discontinue (the STOP-CTX arm) were examined for malaria parasites by quantitative reverse transcription polymerase chain reaction (PCR). Specimens obtained at enrollment and then quarterly for 12 months and at sick visits were assessed; multiplicity of infection was evaluated by PCR that targeted the polymorphic msp-1/msp-2 alleles. Results. Among 500 HIV-infected adults receiving ART (median ART duration, 4.5 years), 5% had detectable parasitemia at baseline. After randomization, parasite prevalence increased over time in the STOP-CTX arm, compared with the CTX arm, with values of 4% and < 1%, respectively, at month 3, 8% and 2% at month 6, 14% and 2% at month 9, and 22% and 4% at month 12 (P =.0034). The combined mean parasite density at the various time points was higher in the STOP-CTX arm (4.42 vs 3.13 log(10) parasites/mL; P <.001). The parasitemia incidence was 42.0 cases per 100 person-years in the STOP-CTX arm and 9.9 cases per 100 person-years in the CTX arm, with an incidence rate ratio of 4.3 (95% confidence interval, 2.7-7.1; P <.001). After enrollment, mixed infections (multiplicity of infection, > 1) were only present in the STOP-CTX arm. Conclusion. Discontinuation of CTX by HIV-infected adults receiving ART resulted in progressive increases in malaria parasitemia prevalence and burden. C1 [Ottichilo, Ronald K.; Nyataya, Josphat; Waitumbi, John N.] Kenya Govt Med Res Ctr, Walter Reed Army Inst Res, US Army Med Res Directorate Kenya, Kisumu, Kenya. [Ottichilo, Ronald K.; Guyah, Bernard] Maseno Univ, Dept Med Immunol, Kisumu, Kenya. [Polyak, Christina S.] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Polyak, Christina S.; John-Stewart, Grace] Walter Reed Army Inst Res, Henry Jackson Fdn, US Mil HIV Res Program, Bethesda, MD USA. [Singa, Benson] Univ Washington, Dept Med, Seattle, WA USA. [Yuhas, Krista; John-Stewart, Grace] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA. [John-Stewart, Grace] Univ Washington, Dept Pediat, Seattle, WA 98195 USA. [John-Stewart, Grace] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. RP Waitumbi, JN (reprint author), Kenya Govt Med Res Ctr, Walter Reed Army Inst Res, US Army Med Res Directorate Kenya, Kisumu, Kenya. EM john.waitumbi@usamru-k.org FU Armed Forces Health Surveillance Branch and its Global Emerging Infections Surveillance and Response section [CO519_11_KY, CO608_12_KY]; Merle A. Sande Award in International Infectious Diseases; Infectious Disease Society of America; Eunice Kenndy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH) [K24-HD054314]; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institute of Mental Health; National Institute on Drug Abuse; NICHD; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institute of General Medical Sciences; National Institute of Diabetes and Digestive Kidney Diseases, NIH [P30AI027757] FX This work was supported by the Armed Forces Health Surveillance Branch and its Global Emerging Infections Surveillance and Response section (ProMIS identifiers CO519_11_KY and CO608_12_KY), the Merle A. Sande Award in International Infectious Diseases, Infectious Disease Society of America; and the Eunice Kenndy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH; grant K24-HD054314 to G. J. S.); and the National Institute of Allergy and Infectious Diseases, the National Cancer Institute, the National Institute of Mental Health, the National Institute on Drug Abuse, the NICHD, the National Heart, Lung, and Blood Institute, the National Institute on Aging, the National Institute of General Medical Sciences, and the National Institute of Diabetes and Digestive Kidney Diseases, NIH (award P30AI027757). NR 28 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 1 PY 2017 VL 215 IS 1 BP 88 EP 94 DI 10.1093/infdis/jiw495 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA EP2HH UT WOS:000397203500015 PM 28077587 ER PT J AU Luken, M Yancosek, KE AF Luken, Michelle Yancosek, Kathleen E. TI Effects of an Occupational Therapy Hand Dominance Transfer Intervention for Soldiers With Crossed Hand-Eye Dominance SO JOURNAL OF MOTOR BEHAVIOR LA English DT Article DE handedness; knowledge of results; lateralization; learning ID OCULAR DOMINANCE; VISUAL-ACUITY; HANDEDNESS; PERFORMANCE; MARKSMEN; ADULTS; SKILL AB Crossed dominance (CD) is defined as an individual's dominant hand and dominant eye being on opposite sides of the body. CD negatively impacts an individual's ability to accurately aim and fire long-barreled guns. The authors developed and evaluated a hand dominance transfer (HDT) intervention to improve the M16 rifle shooting accuracy, efficiency, and skill transfer. Twenty-four U.S. Army soldiers with CD were taught how to handle and fire an M16 rifle using the nondominant hand. Training was conducted at a military, indoor laser-equipped weapons simulator. Accuracy for shooting 40 rounds at baseline with the nondominant eye and dominant hand (NDE/DH) was 22.12 compared to shooting 30.46 with the dominant eye and nondominant hand (DE/NDH). This difference was statistically significant with p = .000. The transfer of shooting accuracy skill (retention) following the HDT intervention was 33.42 with a comparative p value of .100. Efficiency of shooting 10 rounds at baseline with the NDE/DH was 6.3 compared to shooting 7.3 with the DE/NDH. This difference was not statistically significant (p = .107). The transfer of shooting efficiency skill (retention) was 7.96 with a comparative p value of .349. This study supports shooting with the DE/NDH. HDT could be further developed to address the soldiering skill of shooting an M16. C1 [Luken, Michelle] US Army, Ft Drum OT Serv, Ft Drum, NY USA. [Yancosek, Kathleen E.] Brooke Army Med Ctr, Ctr Intrepid, Roger Brooke Dr, San Antonio, TX USA. RP Yancosek, KE (reprint author), Brooke Army Med Ctr, Ctr Intrepid, Roger Brooke Dr, San Antonio, TX USA. EM kyancosek@yahoo.com NR 34 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0022-2895 EI 1940-1027 J9 J MOTOR BEHAV JI J. Mot. Behav. PD JAN-FEB PY 2017 VL 49 IS 1 BP 78 EP 87 DI 10.1080/00222895.2016.1191420 PG 10 WC Neurosciences; Psychology; Psychology, Experimental; Sport Sciences SC Neurosciences & Neurology; Psychology; Sport Sciences GA EN5EN UT WOS:000396028500009 PM 28277965 ER PT J AU Fresconi, F Guidos, B Celmins, I DeSpirito, J Hathaway, W AF Fresconi, Frank Guidos, Bernard Celmins, Ilmars DeSpirito, James Hathaway, Wayne TI Flight Behavior of an Asymmetric Missile Through Advanced Characterization Techniques SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID ORIENTATION ESTIMATOR; PROJECTILE; GUIDANCE; CANARDS AB The maneuvers required for guided flight are often obtained through inducing aerodynamic asymmetries. The goal of this study is better understanding of the behavior of asymmetric flight bodies for enhanced control authority and more accurate aerodynamic characterization to improve guidance algorithm design and component (for example, actuator and feedback sensor) selection. The configuration considered is a missile featuring a pair of canards representative of a class of rolling airframes with a single plane of actuating control surfaces. Free-flight experiments are conducted on this body, which demonstrates a means of collecting high-quality experimental data on guided airframes using roll-yaw resonance. Characterization of the asymmetric aerodynamics are obtained from spark range and computational fluid dynamics techniques. Aerodynamic coefficients compare favorably between spark range, computational fluid dynamics, and onboard sensor techniques. Experiments also validate linearized theory of the amplification factor due to roll-yaw resonance. Lastly, the aerodynamic uncertainty quantified during this study enables the maneuverability design margin to be assessed for asymmetric, rolling airframes. C1 [Fresconi, Frank; Guidos, Bernard; Celmins, Ilmars; DeSpirito, James] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Hathaway, Wayne] Arrow Tech Associates, Burlington, VT 05403 USA. RP Fresconi, F (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 40 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 EI 1533-6794 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD JAN PY 2017 VL 54 IS 1 BP 266 EP 277 DI 10.2514/1.A33593 PG 12 WC Engineering, Aerospace SC Engineering GA EM7UF UT WOS:000395517100022 ER PT J AU Plackett, TP Ton-That, HH Mosier, MJ Abood, GJ Kuo, PC Pappas, SG AF Plackett, Timothy P. Ton-That, Hieu H. Mosier, Michael J. Abood, Gerard J. Kuo, Paul C. Pappas, Sam G. TI Physiologic Response to HIPEC: Sifting Through Perturbation to Identify Markers of Complications SO JOURNAL OF THE AMERICAN OSTEOPATHIC ASSOCIATION LA English DT Article DE chemotherapy; cytoreductive surgery; hyperthermic intraperitoneal chemotherapy; peritoneal carcinomatosis ID HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; CYTOREDUCTIVE SURGERY; SURGICAL COMPLICATIONS; LEARNING-CURVE; TIME-COURSE; CLASSIFICATION; MALIGNANCIES; METAANALYSIS; PARAMETERS; EXPERIENCE AB Context: The postoperative physiologic response to hyperthermic intraperitoneal chemotherapy (HIPEC) has been poorly studied outside of the immediate perioperative time. Objective: To characterize the physiologic response during the first 5 days after HIPEC and identify variables associated with major complications. Methods: Patients undergoing HIPEC and cytoreductive surgery during a 14-month interval were retrospectively identified and their records reviewed for demographics, physiologic response, and major complications. Vital signs and laboratory results were recorded before the operation, immediately after the procedure, and for the first 5 postoperative days. Results: Thirty-three patients were included. The mean body temperature and heart rate were elevated on postoperative day 1 compared with baseline (preoperative) status (37.1 degrees C vs 36.6 degrees C and 103 vs 78 beats/min, respectively) and remained elevated through postoperative day 5. The mean arterial pressure was lower on postoperative day 1 (73 mm Hg) but returned to baseline on postoperative day 3 (93 mm Hg). Mean creatinine level increased on postoperative day 1 (0.96 mg/dL) but returned to baseline on postoperative day 2 (0.87 mg/dL). Fourteen patients (42%) had major complications. The strongest predictors of major complications were a prolonged operative time (519 vs 403 minutes) and extreme changes in body temperature and renal function. Conclusions: Hyperthermic intraperitoneal chemotherapy results in a hypenretabolic response that partially returns to baseline around postoperative day 3. Elevated body temperature and impaired renal function are the best predictors of major complications. C1 [Plackett, Timothy P.; Ton-That, Hieu H.; Mosier, Michael J.; Abood, Gerard J.; Kuo, Paul C.; Pappas, Sam G.] Loyola Univ, Med Ctr, Dept Surg, Maywood, IL 60153 USA. RP Plackett, TP (reprint author), Womack Army Med Ctr, Dept Surg, 2160 S Reilly Rd, Ft Bragg, NC 28310 USA. EM tplacke78@gmail.com NR 23 TC 0 Z9 0 U1 0 U2 0 PU AMER OSTEOPATHIC ASSN PI CHICAGO PA 142 EAST ONTARIO STREET, CHICAGO, IL 60611-2864 USA SN 0098-6151 EI 1945-1997 J9 J AM OSTEOPATH ASSOC JI J. Am. Osteopath. Assoc. PD JAN PY 2017 VL 117 IS 1 BP 16 EP 23 DI 10.7556/jaoa.2017.003 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA EP0WX UT WOS:000397108500003 PM 28055083 ER PT J AU Chan, L Ghoshal, A DeCuir, EA Chen, YP Morse, DE Gordon, MJ AF Chan, Lesley Ghoshal, Amitabh DeCuir, Eric A., Jr. Chen, Yuan Ping Morse, Daniel E. Gordon, Michael J. TI Fabrication and optical behavior of graded-index, moth-eye antireflective structures in CdTe SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID FILM SOLAR-CELLS; BROAD-BAND; OMNIDIRECTIONAL ANTIREFLECTION; WINDOW MATERIALS AB A simple and scalable method, based on dip-coat colloidal lithography, mask reduction, and plasma-based pattern transfer, is presented to create graded-index, moth eye-inspired antireflective features on II-VI semiconductors. Hexagonal arrays of isolated conical frusta with tunable geometry (top diameter = 200-1300 nm, pitch = 310-2530 nm, and height = 790-7100 nm) were realized by isotropic etching of various size silica colloid masks before pattern transfer into the underlying substrate. Substantial increases in single-side direct and total infrared (IR) transmission across the 4-20 mu m range (9%-15% for CdTe thin films and 18% for bulk CdTe) were achieved, in excellent agreement with transfer matrix calculations and finite difference time domain optical simulations. The fabrication method presented can be used to enhance efficiency in multiple IR application areas including photovoltaics, optical system components, detectors, and focal plane array imagers. (C) 2016 American Vacuum Society. C1 [Chan, Lesley; Gordon, Michael J.] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA. [Chan, Lesley; Ghoshal, Amitabh; Morse, Daniel E.; Gordon, Michael J.] Univ Calif Santa Barbara, Inst Collaborat Biotechnol, Santa Barbara, CA 93106 USA. [DeCuir, Eric A., Jr.; Chen, Yuan Ping] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Gordon, MJ (reprint author), Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA.; Gordon, MJ (reprint author), Univ Calif Santa Barbara, Inst Collaborat Biotechnol, Santa Barbara, CA 93106 USA. EM mjgordon@engr.ucsb.edu FU Institute for Collaborative Biotechnologies through U.S. Army Research Office [W911NF-09-0001]; NSF [CHE-0953441]; NSF-GRFP FX This research work was supported by the Institute for Collaborative Biotechnologies through Grant No. W911NF-09-0001 from the U.S. Army Research Office, leveraged equipment supported by an NSF CAREER Award No. CHE-0953441, and utilized the UCSB Nanofab cleanroom facilities. The content of the information herein does not necessarily reflect the position or the policy of the government, and no official endorsement should be inferred. L.C. also thanks the NSF-GRFP for fellowship support. NR 25 TC 0 Z9 0 U1 1 U2 1 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD JAN-FEB PY 2017 VL 35 IS 1 AR 011201 DI 10.1116/1.4971770 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA EM7CG UT WOS:000395468500023 ER PT J AU Taylor, DE AF Taylor, DeCarlos E. TI Convergence acceleration of molecular dynamics methods for shocked materials using velocity scaling SO MOLECULAR PHYSICS LA English DT Article DE Molecular dynamics; shock; Hugoniot ID BORON-CARBIDE; STATE; B4C AB In this work, a convergence acceleration method applicable to extended system molecular dynamics techniques for shock simulations of materials is presented. The method uses velocity scaling to reduce the instantaneous value of the Rankine-Hugoniot conservation of energy constraint used in extended system molecular dynamics methods to more rapidly drive the system towards a converged Hugoniot state. When used in conjunction with the constant stress Hugoniostat method, the velocity scaled trajectories show faster convergence to the final Hugoniot state with little difference observed in the converged Hugoniot energy, pressure, volume and temperature. A derivation of the scale factor is presented and the performance of the technique is demonstrated using the boron carbide armour ceramic as a test material. It is shown that simulation of boron carbide Hugoniot states, from 5 to 20GPa, using both a classical Tersoff potential and an ab initio density functional, are more rapidly convergent when the velocity scaling algorithm is applied. The accelerated convergence afforded by the current algorithm enables more rapid determination of Hugoniot states thus reducing the computational demand of such studies when using expensive ab initio or classical potentials. C1 [Taylor, DeCarlos E.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Taylor, DE (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM decarlos.e.taylor.civ@mail.mil NR 30 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0026-8976 EI 1362-3028 J9 MOL PHYS JI Mol. Phys. PY 2017 VL 115 IS 5 SI SI BP 603 EP 617 DI 10.1080/00268976.2016.1241905 PG 15 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA EN0IQ UT WOS:000395693900013 ER PT J AU Baker, SE Painter, EE Morgan, BC Kaus, AL Petersen, EJ Allen, CS Deyle, GD Jensen, GM AF Baker, Sarah E. Painter, Elizabeth E. Morgan, Brandon C. Kaus, Anna L. Petersen, Evan J. Allen, Christopher S. Deyle, Gail D. Jensen, Gail M. TI Systematic Clinical Reasoning in Physical Therapy (SCRIPT): Tool for the Purposeful Practice of Clinical Reasoning in Orthopedic Manual Physical Therapy SO PHYSICAL THERAPY LA English DT Article ID PERIPHERAL NEUROPATHY; DIAGNOSTIC ERRORS; STRATEGIES; RESIDENCY; EDUCATION; SETTINGS; PATIENT; PAIN AB BACKGROUND AND PURPOSE: Clinical reasoning is essential to physical therapist practice. Solid clinical reasoning processes may lead to greater understanding of the patient condition, early diagnostic hypothesis development, and well-tolerated examination and intervention strategies, as well as mitigate the risk of diagnostic error. However, the complex and often subconscious nature of clinical reasoning can impede the development of this skill. Protracted tools have been published to help guide self-reflection on clinical reasoning but might not be feasible in typical clinical settings. CASE DESCRIPTION: This case illustrates how the Systematic Clinical Reasoning in Physical Therapy (SCRIPT) tool can be used to guide the clinical reasoning process and prompt a physical therapist to search the literature to answer a clinical question and facilitate formal mentorship sessions in postprofessional physical therapist training programs. OUTCOMES: The SCRIPT tool enabled the mentee to generate appropriate hypotheses, plan the examination, query the literature to answer a clinical question, establish a physical therapist diagnosis, and design an effective treatment plan. The SCRIPT tool also facilitated the mentee's clinical reasoning and provided the mentor insight into the mentee's clinical reasoning. The reliability and validity of the SCRIPT tool have not been formally studied. DISCUSSION: Clinical mentorship is a cornerstone of postprofessional training programs and intended to develop advanced clinical reasoning skills. However, clinical reasoning is often subconscious and, therefore, a challenging skill to develop. The use of a tool such as the SCRIPT may facilitate developing clinical reasoning skills by providing a systematic approach to data gathering and making clinical judgments to bring clinical reasoning to the conscious level, facilitate self-reflection, and make a mentored physical therapist's thought processes explicit to his or her clinical mentor. (C) 2016 American Physical Therapy Association. C1 [Baker, Sarah E.; Painter, Elizabeth E.; Morgan, Brandon C.; Petersen, Evan J.; Allen, Christopher S.; Deyle, Gail D.] Army Baylor Univ, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Kaus, Anna L.] Brooke Army Med Ctr, Dept Rehabil Med, Ft Sam Houston, TX 78234 USA. [Jensen, Gail M.] Creighton Univ, Sch Pharm & Hlth Profess, Dept Phys Therapy, Omaha, NE 68178 USA. [Jensen, Gail M.] Creighton Univ, Ctr Hlth Policy & Eth, Omaha, NE 68178 USA. RP Baker, SE (reprint author), Army Baylor Univ, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM sarah.elaine.baker@gmail.com NR 50 TC 0 Z9 0 U1 0 U2 0 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 EI 1538-6724 J9 PHYS THER JI Phys. Ther. PD JAN PY 2017 VL 97 IS 1 BP 61 EP 70 DI 10.2522/ptj.20150482 PG 10 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA EP0UU UT WOS:000397103000008 ER PT J AU Wabel, TM Skiba, AW Temme, JE Driscoll, JF AF Wabel, Timothy M. Skiba, Aaron W. Temme, Jacob E. Driscoll, James F. TI Measurements to determine the regimes of premixed flames in extreme turbulence SO PROCEEDINGS OF THE COMBUSTION INSTITUTE LA English DT Article DE Turbulent combustion; Regime diagram; PLIF; Hi-Pilot Burner; Broken Reactions ID BURNING VELOCITIES; INTENSE TURBULENCE; HEAT-RELEASE; LOCAL FLAME; JET FLAMES; COMBUSTION; OH; PROPAGATION; CH AB A new regime of extreme turbulence - defined as the ratio of turbulence intensity to laminar flame speed u'/S-L from 25 to 243 - was characterized for six premixed flames using a new piloted Bunsen burner (called Hi-Pilot). The flames studied had u'/S-L values several times larger than those of previous related studies and integral scales and turbulent Reynolds numbers as large as 41 mm and 99,000, respectively. Layer thicknesses were determined from planar laser-induced fluorescence (PLIF) images of OH and formaldehyde. Preheat layer thickness was found to increase to sixteen times the laminar value. Residence time of eddies in the flame appears to be important, since the flame tip had preheat regions that were thicker than at the flame base. Reaction layers were not broadened, remaining below twice the laminar value. Four of the cases were predicted to lie in the Broadened Preheat - Thin Reaction layer (BP-TR) regime and the measurements confirmed that they had a BP-TR structure. However, two cases went far beyond the predicted boundary for the Broken Reactions (BR) regime but measurements showed that they were not broken but retained their BP-TR structure. Thus the regime of BP-TR is measured to persist over a wider range than previously predicted. One explanation is that the turbulent eddies may become weakened by the thick, viscous preheat layer before they arrive at the reaction front. Distributed reactions were not observed in the six cases that were selected. (C) 2016 by The Combustion Institute. Published by Elsevier Inc. C1 [Wabel, Timothy M.; Skiba, Aaron W.; Driscoll, James F.] Univ Michigan, Ann Arbor, MI 48109 USA. [Temme, Jacob E.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Wabel, TM (reprint author), Univ Michigan, Ann Arbor, MI 48109 USA. EM twabel@umich.edu FU AFOSR [FA9550-12-1-0101]; National Science Foundation [CBET 0852910] FX The authors gratefully acknowledge Drs. Carter and Hammack for their insightful comments and advice in the preparation of this manuscript. Support for this research was provided by AFOSR Grant FA9550-12-1-0101; additional support was provided by National Science Foundation grant CBET 0852910 NR 36 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1540-7489 EI 1873-2704 J9 P COMBUST INST JI Proc. Combust. Inst. PY 2017 VL 36 IS 2 BP 1809 EP 1816 DI 10.1016/j.proci.2016.08.065 PG 8 WC Thermodynamics; Energy & Fuels; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA EP5ZY UT WOS:000397458900021 ER PT J AU Ray, M Yang, XF Kong, SC Bravo, L Kweon, CBM AF Ray, Manjil Yang, Xiufeng Kong, Song-Charng Bravo, Luis Kweon, Chol-Bum M. TI High-fidelity simulation of drop collision and vapor-liquid equilibrium of van der Waals fluids SO PROCEEDINGS OF THE COMBUSTION INSTITUTE LA English DT Article DE Drop collision; Van der Waals fluid; Smoothed particle hydrodynamics; Vapor-liquid equilibrium ID SMOOTHED PARTICLE HYDRODYNAMICS; TENSILE INSTABILITY; SPH AB The availability of a method to accurately predict the interaction of fuel drops and vapor-liquid equilibrium is crucial to the development of a predictive spray combustion model. The objective of this paper is to present such a method. A numerical method, based on the smoothed particle hydrodynamics (SPH), was coupled with a cubic equation of state for simulating the fuel drop dynamics and liquid-vapor distributions at various temperatures in the present study. SPH is a Lagrangian particle-based method, which is useful to simulate the dynamics of fluids with large deformations without the need for a transport equation to track the interface. The present study, furthermore, coupled SPH with van der Waals equation of state to simulate the phenomena of liquid oscillation, drop collisions at high velocity and characteristics of vapor-liquid equilibrium. This approach was found to offer the convenience of using a single set of equations, without the need for submodels, to predict drop breakup or vaporization. A hyperbolic spline kernel function was employed to eliminate the tensile instability that often has been reported in the literature. The numerical method presented here was found to successfully model the merging, stretching separation, fragmentation, and generation of secondary droplets in high-velocity collisions. In predicting vapor-liquid equilibrium, a variable-smoothing-length function was implemented to better facilitate the evaluation of vapor density at low temperatures. Finally, the results of this study indicate that, as the critical temperature was approached, no clear distinction was observed between the liquid and gas phases. (C) 2016 by The Combustion Institute. Published by Elsevier Inc. C1 [Ray, Manjil; Yang, Xiufeng; Kong, Song-Charng] Iowa State Univ, Dept Mech Engn, 2025 Black Engn Bldg, Ames, IA 50011 USA. [Bravo, Luis; Kweon, Chol-Bum M.] US Army Res Lab, Prop Div, Bldg 4603, Aberdeen Proving Ground, MD 21005 USA. RP Kong, SC (reprint author), Iowa State Univ, Dept Mech Engn, 2025 Black Engn Bldg, Ames, IA 50011 USA. EM kong@iastate.edu FU U.S. Army Research Laboratory; DoD High Performance Computing Modernization Program (HPCMP) FRONTIER Award FX Supports from the U.S. Army Research Laboratory are acknowledged. This work was supported in part by high performance computer time and resources from the DoD High Performance Computing Modernization Program (HPCMP) FRONTIER Award. The Army project is titled "Petascale High Fidelity Simulation of Atomization and Spray/Wall Interactions at High Temperature and Pressure Conditions." NR 17 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1540-7489 EI 1873-2704 J9 P COMBUST INST JI Proc. Combust. Inst. PY 2017 VL 36 IS 2 BP 2385 EP 2392 DI 10.1016/j.proci.2016.06.018 PG 8 WC Thermodynamics; Energy & Fuels; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA EP5ZY UT WOS:000397458900083 ER PT J AU Wolfberg, A AF Wolfberg, Adrian TI Dark Side of Clarity: Its Effect on Knowledge Production and Decision-Making SO SALUS JOURNAL LA English DT Article DE intelligence; analysis; information overload; equivocality; helpfulness; clarity ID EXPLORATION; PERSPECTIVE AB Law enforcement decision-makers rely on intelligence analysts to produce intelligence products that are clear. Yet, intelligence analysts live in a world characterised by ambiguity and information overload. This paper examines the intellectual journey that leads to clarity of thought, and the effect of the dark side of clarity on producing knowledge for decision-making. The paper asked, how does the dark side of clarity manifest itself to analyst and decision-maker? The result is counterintuitive; while the bright side of clarity is expected, and demanded because of its benefit to decision-making, the dark side of clarity co-exists in the shadows of certainty and makes it difficult to think critically. Neither analyst nor decision-maker is likely aware of this negative effect. To make this dark side of clarity visible, recommendations are made that begin with raising analyst awareness by augmenting existing training. Then, decision-maker awareness can be approached through training and facilitated coaching. C1 [Wolfberg, Adrian] US Army War Coll, Dept Natl Secur & Strategy, Def Intelligence, Carlisle, PA 17013 USA. RP Wolfberg, A (reprint author), US Army War Coll, Dept Natl Secur & Strategy, Def Intelligence, Carlisle, PA 17013 USA. EM awolfberg@gmail.com NR 66 TC 0 Z9 0 U1 0 U2 0 PU CHARLES STURT UNIV PI WAGGA WAGGA PA LOCKED BAG 588, WAGGA WAGGA, 2678, AUSTRALIA SN 2202-5677 J9 SALUS J JI Salus J. PY 2017 VL 5 IS 1 BP 1 EP 26 PG 26 WC Criminology & Penology SC Criminology & Penology GA EO1OU UT WOS:000396468600001 ER PT J AU Colas, B AF Colas, Brandon TI What Does Dabiq Do? ISIS Hermeneutics and Organizational Fractures within Dabiq Magazine SO STUDIES IN CONFLICT & TERRORISM LA English DT Article AB The Islamic State of Iraq and Syria (ISIS)'s flagship English-language magazine, Dabiq, is a puzzle. The magazine is not, despite appearances, primarily designed for direct recruiting efforts or inciting violence against the West. In fact, the primary audiences of Dabiq are English-speaking second generation Muslims or converts, Western policymakers, and a third group of current or would-be members of ISIS who are not integrating with the organization itself. The third audience-those members who are failing to function within the organization-is strange to include in an English-language magazine. Why publish organizational weaknesses, in English? One possibility for this puzzle is that the fundamentalist hermeneutics of ISIS is reflected in their own media efforts. One of the assumptions that ISIS holds about their sacred texts is that each text carries a single meaning that reflects the author's original intent. There might be multiple applications of that intent, but each text can only have one intent, and therefore one meaning. Following this logic, a message meant for one person is unlikely to be of utility for another, and so this may be why ISIS exposes their weaknesses as part of the process of correcting their own members. C1 [Colas, Brandon] US Mil Acad, Int Relat, 607 Cullum Rd, West Point, NY 10996 USA. RP Colas, B (reprint author), US Mil Acad, Int Relat, 607 Cullum Rd, West Point, NY 10996 USA. EM brandon.colas@usma.edu NR 26 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1057-610X EI 1521-0731 J9 STUD CONFL TERROR JI Stud. Confl. Terror. PY 2017 VL 40 IS 3 BP 173 EP 190 DI 10.1080/1057610X.2016.1184062 PG 18 WC International Relations; Political Science SC International Relations; Government & Law GA EO7HY UT WOS:000396863000001 ER PT J AU Thomson, R Harrison, AM Trafton, JG Hiatt, LM AF Thomson, Robert Harrison, Anthony M. Trafton, J. Gregory Hiatt, Laura M. TI An Account of Interference in Associative Memory: Learning the Fan Effect SO TOPICS IN COGNITIVE SCIENCE LA English DT Article; Proceedings Paper CT International Conference on Cognitive Modeling CY 2016 CL Univ Pk, Penn State, State College, PA HO Univ Pk, Penn State DE Fan effect; Associative learning; Memory; Priming; Cognitive modeling ID INTEGRATED THEORY; FREE-RECALL; RETRIEVAL AB Associative learning is an essential feature of human cognition, accounting for the influence of priming and interference effects on memory recall. Here, we extend our account of associative learning that learns asymmetric item-to-item associations over time via experience (Thomson, Pyke, Trafton, & Hiatt, 2015) by including link maturation to balance associations between longer-term stability while still accounting for short-term variability. This account, combined with an existing account of activation strengthening and decay, predicts both human response times and error rates for the fan effect (Anderson, 1974; Anderson & Reder, 1999) for both target and foil stimuli. C1 [Thomson, Robert] US Mil Acad, Army Cyber Inst, West Point, NY 10996 USA. [Thomson, Robert; Harrison, Anthony M.; Trafton, J. Gregory; Hiatt, Laura M.] Naval Res Lab, Washington, DC 20375 USA. RP Thomson, R (reprint author), US Mil Acad, Army Cyber Inst, West Point, NY 10996 USA. EM robert.thomson@usma.edu FU Office of the Secretary of Defense/Assistant Secretary of Defense for Research and Engineering; Office of Naval Research FX This work was supported by the Office of the Secretary of Defense/Assistant Secretary of Defense for Research and Engineering (LH) and the Office of Naval Research (LH). The views and conclusions contained in this paper do not represent the official policies of the U.S. Navy, the Department of Defense, or the United States Military Academy. NR 27 TC 1 Z9 1 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1756-8757 EI 1756-8765 J9 TOP COGN SCI JI Top. Cogn. Sci. PD JAN PY 2017 VL 9 IS 1 SI SI BP 69 EP 82 DI 10.1111/tops.12244 PG 14 WC Psychology, Experimental SC Psychology GA EO0QZ UT WOS:000396404300007 PM 28054453 ER PT J AU Olivera, DS Hoard-Fruchey, H Sciuto, AM AF Olivera, Dorian S. Hoard-Fruchey, Heidi Sciuto, Alfred M. TI Evaluation of an in vitro screening model to assess phosgene inhalation injury SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Phosgene; transepithelial electrical resistance; in vitro models; energy metabolism; pulmonary injury ID INDUCED LUNG INJURY; PULMONARY TOXICITY; RAT LUNGS; EXPOSURE; CELLS; RESPONSES; SYSTEM; EDEMA AB Therapeutic development against exposure to toxic gases is hindered by the lack of appropriate models to evaluate candidate compounds prior to animal efficacy studies. In this study, an in vitro, air-liquid interface exposure model has been tested to examine its potential application for screening treatments for phosgene (carbonyl chloride)-induced pulmonary injury. Epithelial cultures on Transwell (R) inserts, combined with a Vitrocell (R) exposure apparatus, provided a physiologically relevant exposure environment. Differentiated human bronchial epithelial (16HBE) cultures were exposed for 8min to phosgene ranging from 0 to 64ppm and assessed for changes in transepithelial electrical resistance (TEER, epithelial barrier integrity), cellular viability (XTT) and post-exposure (PE) cellular metabolic energy status. Exposure to phosgene concentrations >= 8ppm caused dose-dependent and significant decreases in TEER and XTT which did not recover within 24-h PE. In addition, at 64ppm the rate of oxidative glutamine metabolism was significantly inhibited at 6 and 24h after exposure. Glycolytic activities (glucose utilization and lactate production) were also inhibited, but to a lesser extent. Decreased glycolytic function can translate to insufficient energy sources to counteract barrier function failure. Consistent and sensitive markers of phosgene exposure were TEER, cell viability and decreased metabolism. As such, we have assessed an appropriate in vitro model of phosgene inhalation that produced quantifiable alterations in markers of lung cell metabolism and injury in human airway epithelial cells. Data indicate the suitability of this model for testing classes of anti-edemagenic compounds such as corticosteroids or phosphodiesterase inhibitors for evaluating phosgene therapeutics. C1 [Olivera, Dorian S.; Hoard-Fruchey, Heidi; Sciuto, Alfred M.] US Army, Med Res Inst Chem Def, Analyt Toxicol Div, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. [Olivera, Dorian S.] Naval Med Res Unit San Antonio, Craniofacial Hlth & Restorat Med Directorate, Biomat & Environm Surveillance Dept, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. RP Hoard-Fruchey, H (reprint author), US Army, Med Res Inst Chem Def, Analyt Toxicol Div, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM heidi.m.hoard-fruchey.civ@mail.mil FU NIH/NIAID [Y1-A1-6179-02]; USAMRICD [Y1-A1-6179-02] FX This project was supported by an Interagency Agreement between NIH/NIAID and the USAMRICD (Y1-A1-6179-02 "Chemicals Affecting the Respiratory Tract - Pulmonary Toxicant Gases"). The opinions and conclusions in this study are solely those of the authors and are not those of the NIH. NR 32 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1537-6516 EI 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD JAN PY 2017 VL 27 IS 1 BP 45 EP 51 DI 10.1080/15376516.2016.1243183 PG 7 WC Toxicology SC Toxicology GA EM5JG UT WOS:000395347200005 PM 27696922 ER PT J AU Jiwani, AZ Williams, JF Rizzo, JA Chung, KK King, BT Cancio, LC AF Jiwani, Alisha Z. Williams, James F. Rizzo, Julie A. Chung, Kevin K. King, Booker T. Cancio, Leopoldo C. TI Thermal injury patterns associated with electronic cigarettes SO INTERNATIONAL JOURNAL OF BURNS AND TRAUMA LA English DT Article DE Electronic cigarette; e-cigarette; burns; lithium-ion battery AB E-cigarettes are typically lithium-ion battery-operated devices that simulate smoking by heating a nicotine-solution into a vapor that the user inhales. E-cigarette use is becoming rapidly popular as an alternative to traditional cigarette smoking. This report describes an emerging problem associated with e-cigarettes, consisting of 10 thermally injured patients seen at a single burn center over a 2-year period from 2014 to 2016. Our cohort was comprised mainly of young adults who sustained mixed partial and full thickness burns as a result of e-cigarette-related explosions. In many documented scenarios, a malfunctioning or over-heated battery is the cause. Our data support the need for increased awareness among healthcare providers and the general public of the potential harms of e-cigarette use, modification, storage, and charging. C1 [Jiwani, Alisha Z.; Williams, James F.; Rizzo, Julie A.; Chung, Kevin K.; King, Booker T.; Cancio, Leopoldo C.] US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. [Rizzo, Julie A.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Jiwani, AZ (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM alisha.z.jiwani.ctr@mail.mil NR 11 TC 0 Z9 0 U1 0 U2 0 PU E-CENTURY PUBLISHING CORP PI MADISON PA 40 WHITE OAKS LN, MADISON, WI 53711 USA SN 2160-2026 J9 INT J BURNS TRAUMA JI Int. J. Burns Trauma PY 2017 VL 7 IS 1 BP 1 EP 5 PG 5 WC Emergency Medicine SC Emergency Medicine GA EP1NL UT WOS:000397151500001 PM 28123861 ER PT J AU Pak, R Rovira, E McLaughlin, AC Baldwin, N AF Pak, Richard Rovira, Ericka McLaughlin, Anne Collins Baldwin, Natalee TI Does the domain of technology impact user trust? Investigating trust in automation across different consumer-oriented domains in young adults, military, and older adults SO THEORETICAL ISSUES IN ERGONOMICS SCIENCE LA English DT Article DE Trust in automation; domain; aging; complacency; military; technology; stages of automation; levels of automation ID COMBAT IDENTIFICATION SYSTEMS; DECISION-SUPPORT; RELIANCE; AGE; PERFORMANCE; STRATEGIES; FAILURES; HUMANS; MISUSE; DISUSE AB Trust has been shown to be a determinant of automation usage and reliance. Thus, understanding the factors that affect trust in automation has been a focus of much research. Despite the increased appearance of automation in consumer-oriented domains, the majority of research examining human-automation trust has occurred in highly specialised domains (e.g. flight management, military) and with specific user groups. We investigated trust in technology across three different groups (young adults, military, and older adults), four domains (consumer electronics, banking, transportation, and health), two stages of automation (information and decision automation), and two levels of automation reliability (low and high). Our findings suggest that trust varies on an interaction of domain of technology, reliability, stage, and user group. C1 [Pak, Richard; Baldwin, Natalee] Clemson Univ, Dept Psychol, Clemson, SC 29634 USA. [Rovira, Ericka] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [McLaughlin, Anne Collins] North Carolina State Univ, Dept Psychol, Raleigh, NC 27695 USA. RP Pak, R (reprint author), Clemson Univ, Dept Psychol, Clemson, SC 29634 USA. EM richpak@clemson.edu FU Air Force Office of Scientific Research [FA9550-12-1-0385] FX This research was supported by a grant from the Air Force Office of Scientific Research [award number FA9550-12-1-0385]. NR 61 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1463-922X EI 1464-536X J9 THEOR ISS ERGON SCI JI Theor. Iss. Ergon. Sci. PY 2017 VL 18 IS 3 BP 199 EP 220 DI 10.1080/1463922X.2016.1175523 PG 22 WC Ergonomics SC Engineering GA EO7KI UT WOS:000396869200001 ER PT J AU Kesavan, J Humphreys, P Nasr, B Ahmadi, G Knox, CK Valdes, E Rastogi, V Dhaniyala, S AF Kesavan, Jana Humphreys, Pam Nasr, Babak Ahmadi, Goodarz Knox, Craig K. Valdes, Erica Rastogi, Vipin Dhaniyala, Suresh TI Experimental and computational study of reaerosolization of 1 to 5 mu m PSL microspheres using jet impingement SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID PARTICLE RESUSPENSION; TURBULENT FLOWS; WIND-TUNNEL; FINE PARTICLES; FLAT SURFACES; GAS JETS; AIR-JET; REMOVAL; DETACHMENT; ENTRAINMENT AB Chemical, biological, radiological, and explosive incidents produce immediate as well as delayed hazards as a result of reaerosolization of deposited particles from surfaces. Understanding reaerosolization mechanisms is important for hazard prediction and mitigation processes. A method to efficiently reaerosolize 1-5 mu m particles (approximately the size of bacterial spores) has not been previously available; therefore, this study was conducted to test a simple and effective method to reaerosolize such particles. In this work, a high-speed vertical impinging jet was used to reaerosolize 1-5 mu m polystyrene latex microspheres from a substrate, and measured removal efficiencies were compared with the performed numerical predictions. Experiments were conducted to determine the effect of location, number of pulsed air jets, particle size, aerosol generation methodology (wet and dry), and relative humidity (RH) on the amount of reaerosolization. The experimental results agreed with the numerical predictions and demonstrated that maximal reaerosolization efficiency (similar to 90% in several cases) occurs at a few millimeters from the jet center. At the peak removal location, reaerosolization increased with increasing particle size and with increasing number of pulsed air jets. Dry deposited particles exhibited significantly higher reaerosolization compared to wet deposited particles. Equilibration of samples at low (20%) RH showed higher reaerosolization compared to the high RH conditions for dry deposited particles. This study demonstrates the effectiveness of using a single vertical impinging jet for localized reaerosolization of bacteria-sized particles from surfaces. C1 [Kesavan, Jana; Humphreys, Pam; Knox, Craig K.; Valdes, Erica; Rastogi, Vipin] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21005 USA. [Nasr, Babak; Ahmadi, Goodarz; Dhaniyala, Suresh] Clarkson Univ, Mech & Aeronaut Engn, Potsdam, NY USA. [Knox, Craig K.] Leidos Inc, Gunpowder, MD USA. RP Kesavan, J (reprint author), US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21005 USA. EM Jana.S.Kesavan.civ@mail.mil FU Edgewood Chemical Biological Center, Surface Science Initiative; Defense Threat Reduction Agency [HDTRA1-14-C-0009] FX This research was funded by the Edgewood Chemical Biological Center, Surface Science Initiative. SD, BN, and GA would like to thank the Defense Threat Reduction Agency for funding support (contract number: HDTRA1-14-C-0009). NR 29 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0278-6826 EI 1521-7388 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PY 2017 VL 51 IS 3 BP 377 EP 387 DI 10.1080/02786826.2016.1265081 PG 11 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EL5LG UT WOS:000394662000013 ER PT J AU Prasithsirikul, W Chongthawonsatid, S Ohata, PJ Keadpudsa, S Klinbuayaem, V Rerksirikul, P Kerr, SJ Ruxrungtham, K Ananworanich, J Avihingsanon, A AF Prasithsirikul, Wisit Chongthawonsatid, Sukanya Ohata, Pirapon June Keadpudsa, Siriwan Klinbuayaem, Virat Rerksirikul, Patsamon Kerr, Stephen J. Ruxrungtham, Kiat Ananworanich, Jintanat Avihingsanon, Anchalee CA PROGRESS Study Team TI Depression and anxiety were low amongst virally suppressed, long-term treated HIV-infected individuals enrolled in a public sector antiretroviral program in Thailand SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE Depression; anxiety; HIV-1 infected patients; female; efavarenz; Thailand ID QUALITY-OF-LIFE; THERAPY ADHERENCE; SOUTH-AFRICA; PSYCHIATRIC-DISORDERS; MENTAL-HEALTH; FOLLOW-UP; EFAVIRENZ; HIV/AIDS; SYMPTOMS; CARE AB HIV/AIDS and anxiety/depression are interlinked. HIV-infected patients suffering from depression may be at risk for poor adherence which may contribute to HIV disease progression. Additionally, an HIV diagnosis and/or using certain antiretroviral agents may trigger symptoms of anxiety/depression. The objective of the study was to assess the prevalence and factors associated with anxiety and depression in HIV-infected patients from the Thai National HIV Treatment Program. This cross-sectional study was performed from January 2012 to December 2012 in HIV-infected out-patients, aged >= 18 years, from three HIV referral centers. Symptoms of anxiety and depression were measured using the Thai-validated Hospital Anxiety and Depression Scale (HADS). A score of >= 11 was defined as having anxiety and depression. Associated factors were assessed by multivariate logistic regression. Totally 2023 (56% males) patients were enrolled. All patients received antiretroviral therapy (ART) for a mean duration of 7.7 years. Median CD4 was 495 cells/mm(3). Ninety-five percent had HIV-RNA < 50 copies/ml. Thirty-three percent were currently on efavirenz (EFV)-based ART. The prevalence of anxiety and depression were 4.8% and 3.1%, respectively. About 1.3% had both anxiety and depression. In multivariate logistic models, the female sex [OR = 1.6(95% CI 1.1-2.3), p = .01], having adherence < 90% [OR = 2.2(95% CI 1.5-3.4), p <. 001], fair/poor quality of life (QOL) [OR = 7.2 (95% CI 3.6-14.2), p <.001] and EFV exposure [OR = 1.6(95% CI 1.1-2.3), p = .01], were independently associated with having anxiety or depression. Our findings demonstrated that prevalence of depression and anxiety was low amongst virally suppressed, long-term antiretroviral-treated HIV-infected individuals. Some key characteristics such as the female sex, poor adherence, poor/fair QOL and EFV exposure are associated with anxiety and depression. These factors can be used to distinguish who would need a more in-depth evaluation for these psychiatric disorders. C1 [Prasithsirikul, Wisit] Minist Publ Hlth, Bamrasnaradura Infect Dis Inst, Dept Dis Control, Nonthaburi, Thailand. [Chongthawonsatid, Sukanya] Mahidol Univ, Fac Social Sci & Humanities, Nakhon Pathom, Thailand. [Ohata, Pirapon June; Keadpudsa, Siriwan; Rerksirikul, Patsamon; Kerr, Stephen J.; Ruxrungtham, Kiat; Ananworanich, Jintanat; Avihingsanon, Anchalee] Thai Red Cross AIDS Res Ctr, HIV NAT, 104 Ratchadamri Rd, Bangkok 10330, Thailand. [Klinbuayaem, Virat] Sanpatong Hosp, Chiang Mai, Thailand. [Ruxrungtham, Kiat; Avihingsanon, Anchalee] Chulalongkorn Univ, Div Allergy & Immunol, Fac Med, Bangkok, Thailand. [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. [Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. RP Avihingsanon, A (reprint author), Thai Red Cross AIDS Res Ctr, HIV NAT, 104 Ratchadamri Rd, Bangkok 10330, Thailand. EM anchaleea2009@gmail.com FU Department of Disease Control, Ministry of Public Health, Thailand FX This study was sponsored by the Department of Disease Control, Ministry of Public Health, Thailand. NR 70 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0954-0121 EI 1360-0451 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2017 VL 29 IS 3 BP 299 EP 305 DI 10.1080/09540121.2016.1201194 PG 7 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA EL4TG UT WOS:000394613200005 PM 27683949 ER PT J AU Pamies, D Bal-Price, A Simeonov, A Tagle, D Allen, D Gerhold, D Yin, D Pistollato, F Inutsuka, T Sullivan, K Stacey, G Salem, H Leist, M Daneshian, M Vemuri, MC McFarland, R Coecke, S Fitzpatrick, SC Lakshmipathy, U Mack, A Wang, WB Yamazaki, D Sekino, Y Kanda, Y Smirnova, L Hartung, T AF Pamies, David Bal-Price, Anna Simeonov, Anton Tagle, Danilo Allen, Dave Gerhold, David Yin, Dezhong Pistollato, Francesca Inutsuka, Takashi Sullivan, Kristie Stacey, Glyn Salem, Harry Leist, Marcel Daneshian, Mardas Vemuri, Mohan C. McFarland, Richard Coecke, Sandra Fitzpatrick, Suzanne C. Lakshmipathy, Uma Mack, Amanda Wang, Wen Bo Yamazaki, Daiju Sekino, Yuko Kanda, Yasunari Smirnova, Lena Hartung, Thomas TI Good Cell Culture Practice for Stem Cells and Stem-Cell-Derived Models SO ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION LA English DT Editorial Material DE Good Cell Culture Practices; in vitro methods; alternatives to animals; induced pluripotent stem cells ID LINE CROSS-CONTAMINATION; BANKING INITIATIVE ISCBI; SERUM-FREE CELL; HUMAN IPS CELLS; SOMATIC-CELLS; MYCOPLASMA CONTAMINATION; HUMAN ES; CARDIAC DIFFERENTIATION; HOMING ENDONUCLEASE; EPIGENETIC MEMORY AB The first guidance on Good Cell Culture Practice (GCCP) dates back to 2005. This document expands this to include aspects of quality assurance for in vitro cell culture focusing on the increasingly diverse cell types and culture formats used in research, product development, testing and manufacture of biotechnology products and cell-based medicines. It provides a set of basic principles of best practice that can be used in training new personnel, reviewing and improving local procedures, and helping to assure standard practices and conditions for the comparison of data between laboratories and experimentation performed at different times. This includes recommendations for the documentation and reporting of culture conditions. It is intended as guidance to facilitate the generation of reliable data from cell culture systems, and is not intended to conflict with local or higher level legislation or regulatory requirements. It may not be possible to meet all recommendations in this guidance for practical, legal or other reasons. However, when it is necessary to divert from the principles of GCCP, the risk of decreasing the quality of work and the safety of laboratory staff should be addressed and any conclusions or alternative approaches justified. This workshop report is considered a first step toward a revised GCCP 2.0. C1 [Pamies, David; Smirnova, Lena; Hartung, Thomas] Johns Hopkins Univ, Ctr Alternat Anim Testing, Baltimore, MD 21205 USA. [Bal-Price, Anna; Pistollato, Francesca] Joint Res Ctr, European Commiss, Ispra, VA, Italy. [Simeonov, Anton; Tagle, Danilo; Gerhold, David] Natl Ctr Adv Translat Sci Natl Inst Hlth, Rockville, MD USA. [Allen, Dave] Contractor supporting NTP Interagency Ctr Evaluat, Morrisville, NC USA. [Yin, Dezhong] Amer Type Culture Collect ATCC, ATCC Cell Syst, Gaithersburg, MD USA. [Inutsuka, Takashi] Pharmacol Evaluat Inst Japan PEIJ, Tokyo, Japan. [Sullivan, Kristie] Physicians Comm Responsible Med, Washington, DC USA. [Stacey, Glyn] Natl Inst Biol Standardizat & Control, South Mimms, Hertford, England. [Salem, Harry] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Leist, Marcel; Daneshian, Mardas; Hartung, Thomas] Univ Konstanz, Ctr Alternat Anim Testing Europe, Constance, Germany. [Vemuri, Mohan C.] Life Sci Solut, Thermo Fisher Sci, Carlsbad, CA USA. [McFarland, Richard; Fitzpatrick, Suzanne C.] Ctr Food Safety & Appl Nutr FDA, College Pk, MD USA. [Mack, Amanda; Wang, Wen Bo] Cellular Dynam Int, Madison, WI USA. [Yamazaki, Daiju; Sekino, Yuko; Kanda, Yasunari] Natl Inst Hlth Sci, Divis Pharmacol, Tokyo, Japan. RP Hartung, T (reprint author), Johns Hopkins Univ, Ctr Alternat Anim Testing, Baltimore, MD 21205 USA. EM thartun1@jhu.edu FU EU-ToxRisk Project [681002]; German BMBF grant NeuriTox; Japan Agency for Medical Research and Development grants [15mk0104053h0101, 16mk0104027j0002] FX The work on this article was supported by the EU-ToxRisk Project (European Union's Horizon 2020 research programme grant agreement No 681002, to Marcel Leist and Thomas Hartung), and the German BMBF grant NeuriTox (to Marcel Leist). The contribution of Yuko Sekino was supported by Japan Agency for Medical Research and Development grants (ID: 15mk0104053h0101 and 16mk0104027j0002). NR 193 TC 2 Z9 2 U1 0 U2 0 PU SPEKTRUM AKADEMISCHER VERLAG-SPRINGER-VERLAG GMBH PI HEILDEBERG PA TIERGARTENSTRASSE 17, HEILDEBERG, 69121, GERMANY SN 1868-596X EI 1868-8551 J9 ALTEX-ALTERN ANIM EX JI ALTEX-Altern. Anim. Exp. PY 2017 VL 34 IS 1 BP 95 EP 132 DI 10.14573/altex.1607121 PG 38 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EO3RU UT WOS:000396612700006 PM 27554434 ER PT J AU Boonchan, T Wilasrusmee, C McEvoy, M Attia, J Thakkinstian, A AF Boonchan, T. Wilasrusmee, C. McEvoy, M. Attia, J. Thakkinstian, A. TI Network meta-analysis of antibiotic prophylaxis for prevention of surgical-site infection after groin hernia surgery SO BRITISH JOURNAL OF SURGERY LA English DT Review ID OPEN MESH REPAIR; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; INGUINAL-HERNIA; DOUBLE-BLIND; WOUND-INFECTION; ADULT PATIENTS; SOCIETY GUIDELINES; HERNIOPLASTY; HERNIORRHAPHY AB BackgroundFirst-generation cephalosporins (such as cefazolin) are recommended as antibiotic prophylaxis in groin hernia repair, but other broad-spectrum antibiotics have also been prescribed in clinical practice. This was a systematic review and network meta-analysis to compare the efficacy of different antibiotic classes for prevention of surgical-site infection (SSI) after hernia repair. MethodsRCTs were identified that compared efficacy of antibiotic prophylaxis on SSI after inguinal or femoral hernia repair from PubMed and Scopus databases up to March 2016. Data were extracted independently by two reviewers. Network meta-analysis was applied to assess treatment efficacy. The probability of being the best antibiotic prophylaxis was estimated using surface under the cumulative ranking curve (SUCRA) analysis. ResultsFifteen RCTs (5159 patients) met the inclusion criteria. Interventions were first-generation (7 RCTs, 1237 patients) and second-generation (2 RCTs, 532) cephalosporins, -lactam/-lactamase inhibitors (6 RCTs, 619) and fluoroquinolones (2 RCTs, 581), with placebo as the most common comparator (14 RCTs, 2190). A network meta-analysis showed that -lactam/-lactamase inhibitors and first-generation cephalosporins were significantly superior to placebo, with a pooled risk ratio of 044 (95 per cent c.i. 025 to 075) and 062 (042 to 092) respectively. However, none of the antibiotic classes was significantly different from the others. SUCRA results indicated that -lactam/-lactamase inhibitors and first-generation cephalosporins were ranked first and second respectively for best prophylaxis. Conclusion-Lactam/-lactamase inhibitors followed by first-generation cephalosporins ranked as the most effective SSI prophylaxis for adult patients undergoing groin hernia repair. C1 [Boonchan, T.; Thakkinstian, A.] Mahidol Univ, Ramathibodi Hosp, Fac Med, Sect Clin Epidemiol & Biostat, Bangkok, Thailand. [Wilasrusmee, C.] Mahidol Univ, Ramathibodi Hosp, Dept Surg, Fac Med, Bangkok, Thailand. [Boonchan, T.] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [McEvoy, M.; Attia, J.] Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW, Australia. RP Thakkinstian, A (reprint author), Ramathibodi Hosp, Fac Med, Sect Clin Epidemiol & Biostat, 270 Rama 6 Rd, Bangkok 10400, Thailand. EM ammarin.tha@mahidol.ac.th NR 57 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0007-1323 EI 1365-2168 J9 BRIT J SURG JI Br. J. Surg. PD JAN PY 2017 VL 104 IS 2 BP E106 EP E117 DI 10.1002/bjs.10441 PG 12 WC Surgery SC Surgery GA EK0CL UT WOS:000393594000012 PM 28121028 ER PT J AU Certal, V Camacho, M Song, SJA Capasso, R AF Certal, Victor Camacho, Macario Song, Sungjin A. Capasso, Robson TI Introducing a new concept in obstructive sleep apnea: The continuum of treatment SO CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE LA English DT Editorial Material C1 [Certal, Victor] Hosp CUF Porto, Dept Otorhinolaryngol, Sleep Med Ctr, Oporto, Portugal. [Certal, Victor] CHEDV, Aveiro, Portugal. [Certal, Victor] Univ Porto, CINTESIS Ctr Res Hlth Technol & Informat Syst, Oporto, Portugal. [Camacho, Macario; Song, Sungjin A.] Tripler Army Med Ctr, Div Sleep Surg & Med, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. [Capasso, Robson] Stanford Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Sleep Surg Div, Stanford, CA 94305 USA. RP Song, SJA (reprint author), Tripler Army Med Ctr, Div Sleep Surg & Med, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. EM sungjin.song@gmail.com NR 5 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0886-9634 EI 2151-0903 J9 CRANIO JI Cranio-J. Craniomandib. Pract. PY 2017 VL 35 IS 1 BP 1 EP 2 DI 10.1080/08869634.2016.1259864 PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EL2QQ UT WOS:000394464900001 PM 27875929 ER PT J AU Camacho, M Ryhn, MJ Fukui, CS Bager, JM AF Camacho, Macario Ryhn, Michael J. Fukui, Christine S. Bager, Jennifer M. TI Multidisciplinary sleep clinic: A patient-centered approach SO CRANIO-THE JOURNAL OF CRANIOMANDIBULAR PRACTICE LA English DT Letter C1 [Camacho, Macario; Ryhn, Michael J.; Fukui, Christine S.; Bager, Jennifer M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Camacho, M (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. EM drcamachoent@yahoo.com NR 1 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0886-9634 EI 2151-0903 J9 CRANIO JI Cranio-J. Craniomandib. Pract. PY 2017 VL 35 IS 2 BP 129 EP 129 DI 10.1080/08869634.2017.1280246 PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EL2QU UT WOS:000394465300012 PM 28100128 ER PT J AU Patterson, RW AF Patterson, Richard W. TI Could trends in time children spend with parents help explain the black-white gap in human capital? Evidence from the American Time Use Survey SO EDUCATION ECONOMICS LA English DT Article DE Parenting practices; human capital; time allocation; black-white differences ID TEST SCORE GAP; NONCOGNITIVE SKILL FORMATION; ACADEMIC-ACHIEVEMENT; SCHOOL; INVOLVEMENT; FAMILIES; TECHNOLOGY; ATTACHMENT; METAANALYSIS; INEQUALITY AB It is widely believed that the time children spend with parents significantly impacts human capital formation. If time varies significantly between black and white children, this may help explain the large racial gap in test scores and wages. In this study, I use data from the American Time Use Survey to examine the patterns in the time black and white children receive from mothers at each age between birth and age 14 years. I relate patterns in parenting time to trends in human capital formation observed in the literature. I observe that black children spend significantly less time with their mothers than white children in the first years of life. However, differences in parenting time rapidly decline with age and there are never significant differences in teaching time after socioeconomic variables are controlled. My findings suggest that the black-white human capital gap is unlikely to be driven by differences in teaching time or differences in parenting time after children enter school. C1 [Patterson, Richard W.] United States Mil Acad, West Point, NY USA. RP Patterson, RW (reprint author), United States Mil Acad, West Point, NY USA. EM richard.patterson@usma.edu NR 45 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0964-5292 EI 1469-5782 J9 EDUC ECON JI Educ. Econ. PY 2017 VL 25 IS 3 BP 219 EP 233 DI 10.1080/09645292.2016.1235137 PG 15 WC Education & Educational Research SC Education & Educational Research GA EO7AU UT WOS:000396844400001 ER PT J AU Reed, RB Martin, DP Bednar, AJ Montano, MD Westerhoff, P Ranville, JF AF Reed, R. B. Martin, D. P. Bednar, A. J. Montano, M. D. Westerhoff, P. Ranville, J. F. TI Multi-day diurnal measurements of Ti-containing nanoparticle and organic sunscreen chemical release during recreational use of a natural surface water SO ENVIRONMENTAL SCIENCE-NANO LA English DT Article ID SWIMMING POOL WATER; CARE PRODUCTS; SILVER; INGREDIENTS; TEXTILES AB Clear Creek in Golden, Colorado sees a large number of recreational users during summer, which is expected to result in release of sunscreen chemicals to the water. In this study, water samples were collected hourly for 72 hours over a busy holiday weekend, and were analyzed for the organic chemical based (oxybenzone) and inorganic colloidal (titanium dioxide) active sunscreen constituents. An increase in oxybenzone concentration was observed daily during each day's peak recreational use, approximately 12: 00 to 19: 00 h. This corresponded with an increase in titanium concentration. Metals naturally co-occurring with titanium such as aluminum and iron also showed an increase of these elements during bathing periods as well, suggesting the titanium increase may also be partially the result of sediment resuspension, consistent with the shallow water depth. The ratio of titanium to both aluminum and iron increases relative to the background elemental ratios during peak recreational use. Estimates of titanium mass loading suggested that sunscreen use only could not explain the observed Ti : Al and Ti : Fe ratios and that resuspended sediments likely have an elevated titanium metal ratio compared to natural suspended sediments. Single particle ICP-MS (spICP-MS), used to analyze water samples for Ti-containing particles, did not show diurnal trends in total particle number. Overall, this is the first consecutive-multi-day monitoring study for compounds released from sunscreen to a natural water system, and it highlights the challenges in dealing with detection of NPs above a natural background. C1 [Reed, R. B.; Ranville, J. F.] Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA. [Martin, D. P.; Bednar, A. J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Montano, M. D.] Duke Univ, Dept Civil & Environm Engn, Ctr Environm Implicat Nanotechnol, Durham, NC 27708 USA. [Westerhoff, P.] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ 85287 USA. RP Ranville, JF (reprint author), Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA. EM jranvill@mines.edu FU US Environmental Protection Agency through the STAR program [RD83558001]; Network for the Lifecycle of Nanomaterials (LCNano) FX We are very grateful to Mickael Tharaud and Marc Benedetti at the Institute de Physique du Globe de Paris for help with analysis of creek samples by high resolution ICP-MS. Partial funding was provided from the US Environmental Protection Agency through the STAR program (RD83558001) and the Network for the Lifecycle of Nanomaterials (LCNano). The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. The tests described and the resulting data presented herein, unless otherwise noted, were obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 28 TC 0 Z9 0 U1 0 U2 0 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2051-8153 EI 2051-8161 J9 ENVIRON SCI-NANO JI Environ.-Sci. Nano PY 2017 VL 4 IS 1 BP 69 EP 77 DI 10.1039/c6en00283h PG 9 WC Chemistry, Multidisciplinary; Environmental Sciences; Nanoscience & Nanotechnology SC Chemistry; Environmental Sciences & Ecology; Science & Technology - Other Topics GA EL7BV UT WOS:000394777000007 ER PT J AU Gadlage, MJ Ahlbin, JR Gadfort, P Roach, AH Stansberry, S AF Gadlage, Matthew J. Ahlbin, Jonathan R. Gadfort, Peter Roach, Austin H. Stansberry, Scott TI Characterization of Single-Event Transients in Schmitt Trigger Inverter Chains Operating at Subthreshold Voltages SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article DE Radiation effects in ICs; single-event transients; soft errors; subthreshold ID CMOS; CIRCUITS; DESIGN AB Single-event transients (SETs) induced by alpha particles and heavy ions are measured and analyzed with subthreshold voltage SET characterization circuits. Using a Schmitt trigger inverter target chain fabricated in a 65-nm bulk CMOS process, SET pulse widths are captured from an operating voltage down to 0.32 V. At nominal voltages, the Schmitt trigger inverter chain is immune to SETs, but at subthreshold voltages energetic particles can induce SET pulse widths that range up to and over a microsecond. Additionally, the results show that at subthreshold voltages the 28-nm node offers a significant improvement in the SET response over the 65-nm node. C1 [Gadlage, Matthew J.; Roach, Austin H.] NAVSEA Crane, Crane, IN 47522 USA. [Ahlbin, Jonathan R.] Missile Def Agcy, Huntsville, AL 35758 USA. [Gadfort, Peter] Army Res Lab, Adelphi, MD 20783 USA. [Stansberry, Scott] USC ISI, Arlington, VA 22203 USA. RP Gadlage, MJ (reprint author), NAVSEA Crane, Crane, IN 47522 USA. EM matthew.gadlage@navy.mil FU Defense Threat Reduction Agency; NSWC Crane [FY15, FY16] FX This work was supported by the Defense Threat Reduction Agency, and the NSWC Crane FY15 and FY16 Naval Innovative Science and Engineering (NISE/Section 219) program. NR 16 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9499 EI 1558-1578 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD JAN PY 2017 VL 64 IS 1 BP 637 EP 642 DI 10.1109/TNS.2016.2629448 PN 2 PG 6 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA EO6PD UT WOS:000396814100001 ER PT J AU Chua, J Senft, JL Lockett, SJ Brett, PJ Burtnick, MN DeShazer, D Friedlander, AM AF Chua, Jennifer Senft, Jeffrey L. Lockett, Stephen J. Brett, Paul J. Burtnick, Mary N. DeShazer, David Friedlander, Arthur M. TI pH Alkalinization by Chloroquine Suppresses Pathogenic Burkholderia Type 6 Secretion System 1 and Multinucleated Giant Cells SO INFECTION AND IMMUNITY LA English DT Article DE Burkholderia; Madagascar hissing cockroaches; type 3 secretion system; type 6 secretion system; acidification; actin tails; autophagy; chloroquine; multinucleated giant cells; phagosomal escape ID INTRACELLULAR SURVIVAL; VI SECRETION; MURINE MACROPHAGES; IMMUNE-RESPONSE; PSEUDOMALLEI; MALLEI; HOST; THAILANDENSIS; MELIOIDOSIS; FUSION AB Burkholderia mallei and B. pseudomallei cause glanders and melioidosis, respectively, in humans and animals. A hallmark of pathogenesis is the formation of granulomas containing multinucleated giant cells (MNGCs) and cell death. These processes depend on type 6 secretion system 1 (T6SS-1), which is required for virulence in animals. We examined the cell biology of MNGC formation and cell death. We found that chloroquine diphosphate (CLQ), an antimalarial drug, inhibits Burkholderia growth, phagosomal escape, and subsequent MNGC formation. This depends on CLQ's ability to neutralize the acid pH because other alkalinizing compounds similarly inhibit escape and MNGC formation. CLQ inhibits bacterial virulence protein expression because T6SS-1 and some effectors of type 3 secretion system 3 (T3SS-3), which is also required for virulence, are expressed at acid pH. We show that acid pH upregulates the expression of Hcp1 of T6SS-1 and TssM, a protein coregulated with T6SS-1. Finally, we demonstrate that CLQ treatment of Burkholderia-infected Madagascar hissing cockroaches (HCs) increases their survival. This study highlights the multiple mechanisms by which CLQ inhibits growth and virulence and suggests that CLQ be further tested and considered, in conjunction with antibiotic use, for the treatment of diseases caused by Burkholderia. C1 [Chua, Jennifer; Senft, Jeffrey L.; DeShazer, David; Friedlander, Arthur M.] US Army Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. [Lockett, Stephen J.] Frederick Natl Lab Canc Res, Opt Microscopy & Anal Lab, Leidos Biomed Res Inc, Frederick, MD USA. [Brett, Paul J.; Burtnick, Mary N.] Univ S Alabama, Dept Microbiol & Immunol, Mobile, AL 36688 USA. [Friedlander, Arthur M.] Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA. RP Chua, J; Friedlander, AM (reprint author), US Army Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA.; Friedlander, AM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA. EM Jennifer.Chua.ctr@mail.mil; Arthur.M.Friedlander.civ@mail.mil NR 53 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD JAN PY 2017 VL 85 IS 1 AR e00586 DI 10.1128/IAI.00586-16 PG 17 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA EL4RD UT WOS:000394607700005 ER PT J AU Perkins, MW Wong, B Tressler, J Rodriguez, A Sherman, K Andres, J Devorak, J Wilkins, WL Sciuto, AM AF Perkins, Michael W. Wong, Benjamin Tressler, Justin Rodriguez, Ashley Sherman, Katherine Andres, Jaclynn Devorak, Jennifer Wilkins, William L. Sciuto, Alfred M. TI Adverse respiratory effects in rats following inhalation exposure to ammonia: respiratory dynamics and histopathology SO INHALATION TOXICOLOGY LA English DT Article DE ammonia; histopathology; inhalation exposure; plethysmography; respiratory dynamics; respiratory toxicology ID LIQUID-AMMONIA; CONSCIOUS RATS; LUNG-FUNCTION; MANAGEMENT; TOXICITY; VAPOR; RODENTS; INJURY; SOMAN AB Acute respiratory dynamics and histopathology of the lungs and trachea following inhaled exposure to ammonia were investigated. Respiratory dynamic parameters were collected from male Sprague-Dawley rats (300-350g) during (20min) and 24h (10min) after inhalation exposure for 20min to 9000, 20,000, and 23,000ppm of ammonia in a head-only exposure system. Body weight loss, analysis of blood cells, and lungs and trachea histopathology were assessed 1, 3, and 24h following inhalation exposure to 20,000ppm of ammonia. Prominent decreases in minute volume (MV) and tidal volume (TV) were observed during and 24h post-exposure in all ammonia-exposed animals. Inspiratory time (IT) and expiratory time (ET) followed similar patterns and decreased significantly during the exposure and then increased at 24h post-exposure in all ammonia-exposed animals in comparison to air-exposed controls. Peak inspiratory (PIF) and expiratory flow (PEF) significantly decreased during the exposure to all ammonia doses, while at 24h post-exposure they remained significantly decreased following exposure to 20,000 and 23,000ppm. Exposure to 20,000ppm of ammonia resulted in body weight loss at 1 and 3h post-exposure; weight loss was significant at 24h compared to controls. Exposure to 20,000ppm of ammonia for 20min resulted in increases in the total blood cell counts of white blood cells, neutrophils, and platelets at 1, 3, and 24h post-exposure. Histopathologic evaluation of the lungs and trachea tissue of animals exposed to 20,000ppm of ammonia at 1, 3, and 24h post-exposure revealed various morphological changes, including alveolar, bronchial, and tracheal edema, epithelial necrosis, and exudate consisting of fibrin, hemorrhage, and inflammatory cells. The various alterations in respiratory dynamics and damage to the respiratory system observed in this study further emphasize ammonia-induced respiratory toxicity and the relevance of efficacious medical countermeasure strategies. C1 [Perkins, Michael W.; Wong, Benjamin; Tressler, Justin; Rodriguez, Ashley; Sherman, Katherine; Andres, Jaclynn; Devorak, Jennifer; Wilkins, William L.; Sciuto, Alfred M.] US Army Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. RP Wong, B (reprint author), US Army Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM benjamin.j.wong.civ@mail.mil FU National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program [AOD14021-001-00000]; US Army Medical Research Institute of Chemical Defense FX Special thanks to the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program for support (Chemical Affecting the Respiratory Tract - Pulmonary Toxicant Gases, IAA: AOD14021-001-00000). K.S. and J.A. were supported in part by an appointment to the Internship/Research Participation Program for the US Army Medical Research Institute of Chemical Defense, administered by the Oak Ridge Institute for Science and Education through an agreement between the US Department of Energy and the USAMRICD. NR 28 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0895-8378 EI 1091-7691 J9 INHAL TOXICOL JI Inhal. Toxicol. PD JAN PY 2017 VL 29 IS 1 BP 32 EP 41 DI 10.1080/08958378.2016.1277571 PG 10 WC Toxicology SC Toxicology GA EM2DH UT WOS:000395126100005 PM 28183203 ER PT J AU Smoot, AH AF Smoot, Andrew H. TI A battle lost: re-examining the role of German radio intelligence in the Battle of Gumbinnen SO INTELLIGENCE AND NATIONAL SECURITY LA English DT Article AB The East Prussian Campaign of August 1914 is famous for the intercept of Russian clear-text radio messages by German radio operators. English language accounts have long credited German radio intelligence with providing the information that brought on the Battle of Gumbinnen. However, German and Russian language documents and accounts tell a different story. This paper argues that radio intelligence did not provide the information that led to the Battle of Gumbinnen. Instead, the origins, conduct and aftermath of the battle resulted from intelligence errors that caused the German command authorities to misunderstand the location, structure and intentions of the opposing Russian forces. C1 [Smoot, Andrew H.] US Army, Washington, DC 20310 USA. [Smoot, Andrew H.] Natl Secur Agcy, Ft George G Meade, MD USA. EM tannenberg.smoot@gmail.com NR 34 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0268-4527 EI 1743-9019 J9 INTELL NATL SECUR JI Intell. Natl. Secur. PY 2017 VL 32 IS 3 SI SI BP 286 EP 299 DI 10.1080/02684527.2016.1270990 PG 14 WC International Relations SC International Relations GA EO7HO UT WOS:000396862000002 ER PT J AU Sheffield, B Brungart, D Tufts, J Ness, J AF Sheffield, Benjamin Brungart, Douglas Tufts, Jennifer Ness, James TI The effects of elevated hearing thresholds on performance in a paintball simulation of individual dismounted combat SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article; Proceedings Paper CT Annual Conference of the National-Hearing-Conservation-Association (NHCA) CY 2016 CL San Diego, CA SP Natl Hearing Conservat Assoc DE Psychoacoustics; hearing science; hearing conservation; noise; instrumentation ID LISTENERS; NOISE AB Objective: To examine the relationship between hearing acuity and operational performance in simulated dismounted combat. Design: Individuals wearing hearing loss simulation systems competed in a paintball-based exercise where the objective was to be the last player remaining. Four hearing loss profiles were tested in each round (no hearing loss, mild, moderate and severe) and four rounds were played to make up a match. This allowed counterbalancing of simulated hearing loss across participants. Study sample: Forty-three participants across two data collection sites (Fort Detrick, Maryland and the United States Military Academy, New York). All participants self-reported normal hearing except for two who reported mild hearing loss. Results: Impaired hearing had a greater impact on the offensive capabilities of participants than it did on their survival, likely due to the tendency for individuals with simulated impairment to adopt a more conservative behavioural strategy than those with normal hearing. Conclusions: These preliminary results provide valuable insights into the impact of impaired hearing on combat effectiveness, with implications for the development of improved auditory fitness-for-duty standards, the establishment of performance requirements for hearing protection technologies, and the refinement of strategies to train military personnel on how to use hearing protection in combat environments. C1 [Sheffield, Benjamin] United States Army Publ Hlth Ctr, Army Hearing Div, Aberdeen, MD USA. [Sheffield, Benjamin; Brungart, Douglas] Walter Reed Natl Mil Med Ctr, Audiol & Speech Pathol Ctr, Bethesda, MD USA. [Tufts, Jennifer] Univ Connecticut, Dept Speech Language & Hearing Sci, Storrs, CT USA. [Ness, James] United States Mil Acad, Dept Behav Sci & Leadership, West Point, PA USA. [Sheffield, Benjamin] Walter Reed Natl Mil Med Ctr, Natl Mil Audiol & Speech Pathol Ctr, America Bldg,5th Floor,4954 N Palmer Rd, Bethesda, MD 20889 USA. RP Sheffield, B (reprint author), Walter Reed Natl Mil Med Ctr, Natl Mil Audiol & Speech Pathol Ctr, America Bldg,5th Floor,4954 N Palmer Rd, Bethesda, MD 20889 USA. EM benjamin.m.sheffield.civ@mail.mil FU U.S. Army Hearing Program FX The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article. Funding was provided by the U.S. Army Hearing Program. NR 11 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1499-2027 EI 1708-8186 J9 INT J AUDIOL JI Int. J. Audiol. PY 2017 VL 56 SU 1 BP 34 EP 40 DI 10.1080/14992027.2016.1255360 PG 7 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA EM0OY UT WOS:000395018800005 PM 27873538 ER PT J AU Flamme, GA Deiters, KK Tasko, SM Ahroon, WA AF Flamme, Gregory A. Deiters, Kristy K. Tasko, Stephen M. Ahroon, William A. TI Acoustic reflexes are common but not pervasive: evidence from the National Health and Nutrition Examination Survey, 1999-2012 SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article; Proceedings Paper CT Annual Conference of the National-Hearing-Conservation-Association (NHCA) CY 2016 CL San Diego, CA SP Natl Hearing Conservat Assoc DE Noise; middle ear; demographics; epidemiology; hearing conservation ID TEMPORARY THRESHOLD SHIFT; STAPEDIUS REFLEX; TIME COURSE; HEARING; NOISE; MAGNITUDE; IMPEDANCE; EXPOSURE; DURATION; STIMULI AB Objective: To determine whether acoustic reflexes are pervasive (i.e. sufficiently prevalent to provide 95% confidence of at least 95% prevalence) and might be invoked in damage-risk criteria (DRC) and health hazard assessments (HHA) for impulsive noise.Design: Cross-sectional analyses of a nationally-representative study.Study sample: National Health and Nutrition Examination Survey (NHANES) data collected between 1999 and 2012 were used. Over 60 thousand reflex traces obtained from 15,106 NHANES participants were used in the study, along with demographic, audiometric, health and exposure variables obtained in that study.Results: Acoustic reflexes were not sufficiently prevalent to be deemed pervasive by any detection method or in any subgroup defined by age or audiometric characteristics. The odds of observing acoustic reflexes were greater for women, young adults, and people with better hearing sensitivity. Abnormally high tympanometric admittance and Other race/ethnicity (i.e. people who do not self-identify as exclusively Non-Hispanic White, Non-Hispanic Black, Mexican-American, or Hispanic) were associated with lower odds.Conclusions: Acoustic reflexes are not sufficiently prevalent to be included in DRC and HHA for impulsive noise. C1 [Flamme, Gregory A.; Deiters, Kristy K.; Tasko, Stephen M.] Western Michigan Univ, Dept Speech Pathol & Audiol, 1903 W Michigan Ave, Kalamazoo, MI 49008 USA. [Ahroon, William A.] US Army Aeromed Res Lab, Auditory Protect & Performance Div, Ft Rucker, AL USA. RP Flamme, GA (reprint author), Western Michigan Univ, Dept Speech Pathol & Audiol, 1903 W Michigan Ave, Kalamazoo, MI 49008 USA. EM greg.flamme@wmich.edu FU U.S. Army Medical Research and Materiel Command [W81XWH-14-2-0140] FX This work was supported by the U.S. Army Medical Research and Materiel Command Award number W81XWH-14-2-0140. The views, opinions and/or findings contained in this report are those of the authors and are not an official Department of the Army position, policy, or decision. Citation of trade names in this report does not constitute an endorsement or approval of the use of such commercial items. NR 61 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 1499-2027 EI 1708-8186 J9 INT J AUDIOL JI Int. J. Audiol. PY 2017 VL 56 SU 1 BP 52 EP 62 DI 10.1080/14992027.2016.1257164 PG 11 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA EM0OY UT WOS:000395018800007 PM 27869511 ER PT J AU Keith, B Ford, DN Horton, R AF Keith, Bruce Ford, David N. Horton, Radley TI Considerations in managing the fill rate of the Grand Ethiopian Renaissance Dam Reservoir using a system dynamics approach SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY TECHNOLOGY-JDMS LA English DT Article DE Nile River Basin; Grand Ethiopian Renaissance Dam; reservoir fill rates; system dynamics ID CLIMATE-CHANGE; IMPACTS AB The purpose of this study is to evaluate simulated fill rate scenarios for the Grand Ethiopian Renaissance Dam while taking into account plausible climate change outcomes for the Nile River Basin. The region lacks a comprehensive equitable water resource management strategy, which creates regional security concerns and future possible conflicts. We employ climate estimates from 33 general circulation models within a system dynamics model as a step in moving toward a feasible regional water resource management strategy. We find that annual reservoir fill rates of 8-15% are capable of building hydroelectric capacity in Ethiopia while concurrently ensuring a minimum level of stream flow disruption into Egypt before 2039. Insofar as climate change estimates suggest a modest average increase in stream flow into the Aswan, climate changes through 2039 are unlikely to affect the fill rate policies. However, larger fill rates will have a more detrimental effect on stream flow into the Aswan, particularly beyond a policy of 15%. While this study demonstrates that a technical solution for reservoir fill rates is feasible, the corresponding policy challenge is political. Implementation of water resource management strategies in the Nile River Basin specifically and Africa generally will necessitate a national and regional willingness to cooperate. C1 [Keith, Bruce] US Mil Acad, Dept Syst Engn, Sociol, West Point, NY 10996 USA. [Ford, David N.] Texas A&M Univ, Zachry Dept Civil Engn, Construct Engn & Management, College Stn, TX 77843 USA. [Horton, Radley] Columbia Univ, Earth Inst, New York, NY 10027 USA. RP Keith, B (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM bkeith.global@gmail.com FU US Army Engineer Research and Development Center's Coastal & Hydraulics Laboratory FX Project funding was provided by the US Army Engineer Research and Development Center's Coastal & Hydraulics Laboratory. NR 30 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1548-5129 EI 1557-380X J9 J DEF MODEL SIMUL-AP JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS PD JAN PY 2017 VL 14 IS 1 BP 33 EP 43 DI 10.1177/1548512916680780 PG 11 WC Engineering, Multidisciplinary SC Engineering GA EL8AD UT WOS:000394841600004 ER PT J AU Carley, KM Morgan, GP Lanham, MJ AF Carley, Kathleen M. Morgan, Geoffrey P. Lanham, Michael J. TI Deterring the development and use of nuclear weapons: A multi-level modeling approach SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY TECHNOLOGY-JDMS LA English DT Article DE Agent-based model; dynamic-network; simulation; multi-level modeling AB We describe a multi-country, multi-stakeholder model for the accrual and use of nuclear weapons and illustrate the model's value for addressing nuclear weapon proliferation issues using an historic Pacific Rim scenario. We instantiate the agent-based dynamic-network model for information and belief diffusion using data from subject matter experts and data mined from open source news documents. We present the techniques that supported model instantiation. A key feature of this model and these techniques is enabling rapid model reuse through the ability to instantiate at two levels: generically and for specific cases. We demonstrate these generic and specific cases using a scenario regarding North Korea's interest in nuclear weapons and the resulting impact on the Pacific Rim circa 2014that is, prior to the fourth and fifth nuclear weapons test by the Democratic People's Republic of Korea. A key feature of this model is that it uses two levels of network interactioncountry level and stakeholder levelthus supporting the inclusion of non-state actors and the assessment of complex scenarios. Using this model, we conducted virtual experiments in which we assessed the impact of alternative courses of action on the overall force posture and desire to develop and use nuclear weapons. C1 [Carley, Kathleen M.] Carnegie Mellon Univ, Computat Org & Soc, Sch Comp Sci, Pittsburgh, PA 15213 USA. [Morgan, Geoffrey P.] Carnegie Mellon Univ, Societal Comp Program, Sch Comp Sci, Pittsburgh, PA 15213 USA. [Lanham, Michael J.] US Mil Acad, Comp Sci, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Carley, KM (reprint author), Carnegie Mellon Univ, CASOS, ISR, SCS, 5000 Forbes Ave,4209 Wean Hall, Pittsburgh, PA 15213 USA. EM kathleen.carley@cs.cmu.edu FU Defense Threat Reduction Agency [HDTRA11010102]; Air Force Office of Sponsored Research [FA9550-11-1-0179]; Center for Computational Analysis of Social and Organizational Systems FX This work was sponsored in part by the Defense Threat Reduction Agency (grant number HDTRA11010102) and by the Air Force Office of Sponsored Research (grant number FA9550-11-1-0179). Additional support was provided by the Center for Computational Analysis of Social and Organizational Systems. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Defense Threat Reduction Agency, the Air Force Office of Sponsored Research or the US Government. NR 46 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1548-5129 EI 1557-380X J9 J DEF MODEL SIMUL-AP JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS PD JAN PY 2017 VL 14 IS 1 BP 95 EP 105 DI 10.1177/1548512916681867 PG 11 WC Engineering, Multidisciplinary SC Engineering GA EL8AD UT WOS:000394841600008 ER PT J AU Puszynski, JA Mehta, N Oyler, KD Cheng, G Shah, A Yee, K Bichay, M AF Puszynski, Jan A. Mehta, Neha Oyler, Karl D. Cheng, Gartung Shah, Akash Yee, Kin Bichay, Magdy TI Improved Safety and Loadability of Coated DBX-1 SO JOURNAL OF ENERGETIC MATERIALS LA English DT Article DE DBX-1 coating; flowability; primary explosive; PVB AB Several additives such as polyvinylpyrrolidone (PVP), polyvinyl butyral (PVB), and ethyl cellulose (Ethocel (TM)) were selected to improve the flowability and safe pressing of copper(I) 5-nitrotetrazolate (DBX-1), a green replacement for lead azide currently under development. These properties are important for pressing the material into small-volume detonators, especially during manufacturing when saving cost, while maximizing efficiency and safety, is critical. Sensitivity tests such as ball drop impact, Bundesanstalt fur Materialprufung (BAM) friction, and electrostatic discharge (ESD) along with compatibility testing and performance testing in M55 stab detonators were conducted. For comparison, all testing was done on both uncoated DBX-1 (control sample) and DBX-1 coated with various additives. DBX-1 coated with PVP and PVB showed better flowability compared to the Ethocel additive. Moreover, a considerable safety improvement during pressing was observed with all coated DBX-1 samples compared to the uncoated control batch; whereas uncoated DBX-1 typically detonates when pressed to 35-40 kpsi, the coated DBX-1 could be pressed to greater than 70 kpsi with no adverse effect. More studies will need to be completed to find a suitable solvent for the safe long-term storage of DBX-1. C1 [Puszynski, Jan A.] South Dakota Sch Mines & Technol, Dept Chem & Biol Engn, Rapid City, SD 57701 USA. [Mehta, Neha; Oyler, Karl D.; Cheng, Gartung; Shah, Akash; Yee, Kin] US Army, Explos Dev Branch, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. [Bichay, Magdy] NSWC IH, Indian Head, MD 20640 USA. RP Mehta, N (reprint author), US Army, Explos Dev Branch, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. EM neha.mehta.civ@mail.mil FU Project Director Joint Services (PD-JS) FX This effort was funded by the Project Director Joint Services (PD-JS). NR 6 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0737-0652 EI 1545-8822 J9 J ENERG MATER JI J. Energ. Mater. PY 2017 VL 35 IS 2 BP 233 EP 238 DI 10.1080/07370652.2016.1263692 PG 6 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical; Materials Science, Multidisciplinary SC Chemistry; Engineering; Materials Science GA EO4SV UT WOS:000396685500010 ER PT J AU Wallace, R Giannakoudakis, DA Florent, M Karwacki, CJ Bandosz, T AF Wallace, Rajiv Giannakoudakis, Dimitrios A. Florent, Marc Karwacki, Christopher J. Bandosz, Teresa TI Ferrihydrite deposited on cotton textiles as protection media against the chemical warfare agent surrogate (2-chloroethyl ethyl sulfide) SO JOURNAL OF MATERIALS CHEMISTRY A LA English DT Article ID METAL-ORGANIC FRAMEWORK; MUSTARD GAS SURROGATE; REACTIVE ADSORPTION; OXIDE COMPOSITES; CELLULOSE; DESTRUCTION; DEGRADATION; SIMULANT; REMOVAL; PHASE AB An active phase of ferrihydrite was deposited on cotton using a simple dip-and-dry process. The iron loading was between 4 and 10%, depending on the form of cotton and the number of dip-and-dry cycles. The materials were tested for the removal of a mustard gas surrogate, 2-chloroethyl ethyl sulfide (CEES). The modified fibers showed enhanced photoreactivity and adsorption performance compared to bulk ferrihydrite. The analysis of the headspace and of the surface of the samples after exposure to CEES revealed the presence of reaction products, indicating the high chemical activity of the ferrihydrite phase. Reaction mechanisms involving sulfonium intermediates are proposed. The chemical activity is linked to the high dispersion of the inorganic phase, which increases the number of available catalytic sites and thus enhances the direct contact of these actives sites (OH terminal groups, Fe3+, defects) with CEES. C1 [Wallace, Rajiv; Giannakoudakis, Dimitrios A.; Florent, Marc; Bandosz, Teresa] CUNY, Dept Chem, New York, NY 10031 USA. [Giannakoudakis, Dimitrios A.; Bandosz, Teresa] CUNY, Grad Ctr, PhD Program Chem, New York, NY 10016 USA. [Karwacki, Christopher J.] US Army, Res Dev & Engn Command, Edgewood Chem Biol Ctr, APG, 5183 Blackhawk Rd, Aberdeen, MD 21010 USA. RP Bandosz, T (reprint author), CUNY, Dept Chem, New York, NY 10031 USA.; Bandosz, T (reprint author), CUNY, Grad Ctr, PhD Program Chem, New York, NY 10016 USA. EM tbandosz@ccny.cuny.edu FU DTRA (ARO) [W911-13-0225] FX The authors gratefully acknowledge DTRA for financial support (ARO grant No. W911-13-0225). NR 34 TC 0 Z9 0 U1 0 U2 0 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7488 EI 2050-7496 J9 J MATER CHEM A JI J. Mater. Chem. A PY 2017 VL 5 IS 10 BP 4972 EP 4981 DI 10.1039/c6ta09548h PG 10 WC Chemistry, Physical; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Energy & Fuels; Materials Science GA EN6XO UT WOS:000396146900026 ER PT J AU Byrne, DC Murphy, WJ Krieg, EF Ghent, RM Michael, KL Stefanson, EW Ahroon, WA AF Byrne, David C. Murphy, William J. Krieg, Edward F. Ghent, Robert M. Michael, Kevin L. Stefanson, Earl W. Ahroon, William A. TI Inter-laboratory comparison of three earplug fit-test systems SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE Fit-test; hearing protection; noise reduction rating ID HEARING PROTECTION DEVICES; FIELD ATTENUATION; PERFORMANCE; PROTOCOL AB The National Institute for Occupational Safety and Health (NIOSH) sponsored tests of three earplug fit-test systems (NIOSH HPD Well-Fit, Michael & Associates FitCheck, and Honeywell Safety Products VeriPRO). Each system was compared to laboratory-based real-ear attenuation at threshold (REAT) measurements in a sound field according to ANSI/ASA S12.6-2008 at the NIOSH, Honeywell Safety Products, and Michael & Associates testing laboratories. An identical study was conducted independently at the U.S. Army Aeromedical Research Laboratory (USAARL), which provided their data for inclusion in this article. The Howard Leight Airsoft premolded earplug was tested with twenty subjects at each of the four participating laboratories. The occluded fit of the earplug was maintained during testing with a soundfield-based laboratory REAT system as well as all three headphone-based fit-test systems. The Michael & Associates lab had the highest average A-weighted attenuations and smallest standard deviations. The NIOSH lab had the lowest average attenuations and the largest standard deviations. Differences in octave-band attenuations between each fit-test system and the American National Standards Institute (ANSI) sound field method were calculated (Atten(fit-test) - Atten(ANSI)). A-weighted attenuations measured with FitCheck and HPD Well-Fit systems demonstrated approximately +/- 2dB agreement with the ANSI sound field method, but A-weighted attenuations measured with the VeriPRO system underestimated the ANSI laboratory attenuations. For each of the fit-test systems, the average A-weighted attenuation across the four laboratories was not significantly greater than the average of the ANSI sound field method. Standard deviations for residual attenuation differences were about +/- 2dB for FitCheck and HPD Well-Fit compared to +/- 4dB for VeriPRO. Individual labs exhibited a range of agreement from less than a dB to as much as 9.4dB difference with ANSI and REAT estimates. Factors such as the experience of study participants and test administrators, and the fit-test psychometric tasks are suggested as possible contributors to the observed results. C1 [Byrne, David C.] NIOSH, Robert A Taft Labs, 1090 Tusculum Ave,Mail Stop C-27, Cincinnati, OH 45226 USA. [Murphy, William J.; Krieg, Edward F.] NIOSH, Cincinnati, OH 45226 USA. [Ghent, Robert M.] Honeywell Safety Prod, San Diego, CA USA. [Michael, Kevin L.] Michael & Associates, State Coll, PA USA. [Stefanson, Earl W.; Ahroon, William A.] US Army Aeromed Res Lab, Ft Rucker, AL USA. RP Byrne, DC (reprint author), NIOSH, Robert A Taft Labs, 1090 Tusculum Ave,Mail Stop C-27, Cincinnati, OH 45226 USA. EM dbyrne@cdc.gov NR 27 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2017 VL 14 IS 4 BP 294 EP 305 DI 10.1080/15459624.2016.1250002 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA EM8XN UT WOS:000395594500011 PM 27786602 ER PT J AU Lakshminarayan, VK Sitaraman, J Wissink, AM AF Lakshminarayan, Vinod K. Sitaraman, Jayanarayanan Wissink, Andrew M. TI Application of Strand Grid Framework to Complex Rotorcraft Simulations SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID FLOW COMPUTATIONS; ALGORITHM AB The strand grid approach is a flow solution method where a prismatic-like grid using "strands" is grown to a short distance from the body surface to capture the viscous boundary layer, and the rest of the domain is covered using an adaptive Cartesian grid. The approach offers several advantages in terms of nearly automatic grid generation and adaptation, ability to implement fast and efficient flow solvers that use structured data in both the strand and Cartesian grids, and the development of an efficient and highly scalable domain connectivity algorithm. An earlier work by the authors introduced a strand grid solver called mStrand, which will appear in future versions of the HPCMP CREATETM-AV Helios framework. This paper presents application of the mStrand/Helios strand grid framework for complex rotorcraft problems. The test cases presented are the UH-60A high-speed forward flight and high-altitude stall problems as well as the HART II blade-vortex interaction problem. The results show that the solution obtained using the strand grid framework is as good as that obtained using well-established structured and unstructured solution methodologies. C1 [Lakshminarayan, Vinod K.] NASA, Ames Res Ctr, Sci & Tech Corp, Moffett Field, CA 94035 USA. [Sitaraman, Jayanarayanan] Parallel Geometr Algorithms LLC, Sunnyvale, CA USA. [Wissink, Andrew M.] US Army, Aviat Dev Directorate ADD AMRDEC, Moffett Field, CA USA. RP Lakshminarayan, VK (reprint author), NASA, Ames Res Ctr, Sci & Tech Corp, Moffett Field, CA 94035 USA. EM vinod.k.lakshminarayan.ctr@mail.mil FU U.S. Department of Defense HPC Modernization Program Office FX Material presented in this paper is a product of the CREATE-AV Element of the Computational Research and Engineering for Acquisition Tools and Environments (CREATE) Program sponsored by the U.S. Department of Defense HPC Modernization Program Office. This work was conducted at the High Performance Computing Institute for Advanced Rotorcraft Modeling and Simulation (HIARMS). The authors would like to acknowledge Buvana Jayaraman and Beatrice Roget for providing help while setting up various cases. NR 43 TC 0 Z9 0 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JAN PY 2017 VL 62 IS 1 AR 012008 DI 10.4050/JAHS.62.012008 PG 16 WC Engineering, Aerospace SC Engineering GA EK7TQ UT WOS:000394128500008 ER PT J AU Ramasamy, M Yamauchi, GK AF Ramasamy, Manikandan Yamauchi, Gloria K. TI Using Model-Scale Tandem-Rotor Measurements in Ground Effect to Understand Full-Scale CH-47D Outwash SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID JET AB Downwash and outwash characteristics of a model-scale tandem-rotor system in the presence of the ground were analyzed by identifying and understanding the physical mechanisms contributing to the observed flow field behavior. A building block approach was followed in simplifying the problem, separating the effects of the fuselage, effects of one rotor on the other, etc. Flow field velocities were acquired in a vertical plane at four aircraft azimuths of a small-scale tandem rotor system using the particle image velocimetry technique for radial distances up to four times the rotor diameter. Results were compared against full-scale CH-47D measurements. Excellent correlation was found between the small-and full-scale mean flow fields (after appropriate normalization using rotor and wall jet parameters). Following the scalability analysis, the effect of rotor height on the outwash was also studied. Close to the aircraft, an increase in rotor height above ground decreased the outwash velocity at all aircraft azimuths. However, farther away, the longitudinal and lateral axes of the aircraft showed increasing and decreasing outwash velocities, respectively, with increasing rotor height. Baseline rotor measurements were made out-of-ground effect to understand the nature of inflow distribution for realistic rotor configurations and their modified characteristics in the presence of the ground. C1 [Ramasamy, Manikandan] US Army, Aviat Dev Directorate AFDD, Aviat & Missile Res Dev & Engn Ctr, Res Dev & Engn Command,Ames Res Ctr, Moffett Field, CA 94035 USA. [Yamauchi, Gloria K.] NASA, Ames Res Ctr, Aeromech Off, Moffett Field, CA 94035 USA. RP Ramasamy, M (reprint author), US Army, Aviat Dev Directorate AFDD, Aviat & Missile Res Dev & Engn Ctr, Res Dev & Engn Command,Ames Res Ctr, Moffett Field, CA 94035 USA. EM manikandan.ramasamy.civ@mail.mil NR 30 TC 0 Z9 0 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 EI 2161-6027 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JAN PY 2017 VL 62 IS 1 AR 012004 DI 10.4050/JAHS.62.012004 PG 14 WC Engineering, Aerospace SC Engineering GA EK7TQ UT WOS:000394128500004 ER PT J AU Camacho, M Wei, JM Tolisano, AM Song, SA AF Camacho, Macario Wei, Justin M. Tolisano, Anthony M. Song, Sungjin A. TI In Response to Hyoid Surgery Alone for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis SO LARYNGOSCOPE LA English DT Letter ID METAANALYSIS C1 [Camacho, Macario; Wei, Justin M.; Tolisano, Anthony M.; Song, Sungjin A.] Tripler Army Med Ctr, Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA. [Camacho, Macario] Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat & Behav Sci, Stanford, CA USA. RP Camacho, M (reprint author), Tripler Army Med Ctr, Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA.; Camacho, M (reprint author), Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat & Behav Sci, Stanford, CA USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0023-852X EI 1531-4995 J9 LARYNGOSCOPE JI Laryngoscope PD JAN PY 2017 VL 127 IS 1 BP E54 EP E54 DI 10.1002/lary.26187 PG 1 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA EL9PB UT WOS:000394951400012 PM 27452414 ER PT J AU Winkler, JL Skovira, JW Kan, RK AF Winkler, Jennifer L. Skovira, Jacob W. Kan, Robert K. TI Anticonvulsant efficacy of antihistamine cyproheptadine in rats exposed to the chemical warfare nerve agent soman SO NEUROTOXICOLOGY LA English DT Article DE Nerve agent; Soman; Seizure; Anticholinergic; Cyproheptadine; Neuropathology ID INDUCED SEIZURES; INDUCED CONVULSIONS; GUINEA-PIGS; BRAIN; PREVENTION; ATROPINE; DIPHENHYDRAMINE; NEUROPATHOLOGY; ANTAGONISTS; PROTECTION AB Organophosphate compounds, such as soman and sarin, are highly toxic chemical warfare nerve agents that cause a build-up of acetylcholine in synapses and neuromuscular junctions. Current therapies aim to prevent seizures and protect against brain injury following exposure. The present study was designed to evaluate the effectiveness of the antihistamine cyproheptadine in improving survival and controlling seizures in rats exposed to soman. Rats were pretreated with the oxime reactivator HI-6 (125 mg/kg, ip) 30 min prior to somanexposure(225 mu g/kg, sc) and then treated with atropine methylnitrate (AMN, 2.0 mg/kg, im) 1 min after soman. Cyproheptadine (10, 13, 16 or 20 mg/kg, ip) was given at one of three time points: 1 min after soman intoxication, at the onset of soman-induced seizures or 5 min after seizure onset. Control animals were exposed to soman and given an equivalent volume of sterile water instead of cyproheptadine. The incidence of seizures, mortality, neuron counts, neuropathology and apoptosis in specific regions of the brain were evaluated. In animals given HI-6 and AMN the incidence of somaninduced seizure and mortality rate within the first 24 h were 100%. When cyproheptadine was given at a dose of 13 or 20 mg/kg 1 min after soman exposure, the incidence of seizures was reduced from 100% to 13% and 30%, respectively. In addition, cyproheptadine given at 1 min after soman exposure increased the survival rate to 100% regardless of dose. When cyproheptadine was administered at seizure onset, seizures were terminated in 100% of the animals at doses above 10 mg/kg. The survival rate with cyproheptadine treatment at the onset of seizure was >= 83%. Seizures terminated in >= 75% of the animals that received cyproheptadine 5 min after soman-induced seizure onset. When given at 5 min after seizure onset the survival rate was 100% at all tested doses of cyproheptadine. The neuropathology scores and the number of TUNEL positive cells in the brain regions examined decreased at all time points and cyproheptadine doses tested. These observations indicate that cyproheptadine treatment can effectively control seizures, improve survival, reduce seizure duration and reduce the number of dying cells in the brain following soman exposure.(C) 2016 Elsevier B.V. All rights reserved. C1 [Winkler, Jennifer L.; Skovira, Jacob W.; Kan, Robert K.] US Army Med Res Inst Chem Def, Div Pharmacol, 21010-5400 Ricketts Point Rd, Aberdeen Proving Ground, MD 54141 USA. [Kan, Robert K.] 319 Hill Valley Court, Simi Valley, CA 93065 USA. RP Winkler, JL (reprint author), US Army Med Res Inst Chem Def, Div Pharmacol, 21010-5400 Ricketts Point Rd, Aberdeen Proving Ground, MD 54141 USA. EM jennifer.l.winkler9.ctr@mail.mil; jacob.w.skovira.civ@mail.mil; kwailude1@yahoo.com FU Defense Threat Reduction Agency - Joint Science and Technology Office FX The views expressed in this paper are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the U.S. Government. The experimental protocol was approved by the Animal Care and Use Committee at the United States Army Medical Research Institute of Chemical Defense, and all procedures were conducted in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals and the Animal Welfare Act of 1966 (P.L. 89-544), as amended. This research was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office. J.L Winkler was supported in part by an appointment to the Research Participation Program for the U.S. Army Medical Research and Materiel Command administered by the Oak Ridge Institute for Science Education through an agreement between the U.S. Department of Energy and U.S. Army Medical Research and Materiel Command. NR 36 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X EI 1872-9711 J9 NEUROTOXICOLOGY JI Neurotoxicology PD JAN PY 2017 VL 58 BP 153 EP 160 DI 10.1016/j.neuro.2016.12.004 PG 8 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA EL1UJ UT WOS:000394406400018 PM 27988303 ER PT J AU Keefer, ML Caudill, CC Johnson, EL Clabough, TS Boggs, CT Johnson, PN Nagy, WT AF Keefer, Matthew L. Caudill, Christopher C. Johnson, Eric L. Clabough, Tami S. Boggs, Charles T. Johnson, Peter N. Nagy, William T. TI Inter-observer Bias in Fish Classification and Enumeration Using Dual-frequency Identification Sonar (DIDSON): A Pacific Lamprey Case Study SO NORTHWEST SCIENCE LA English DT Article DE Entosphenus tridentatus; imaging sonar; quality control; sensitivity analysis; species discrimination ID COLUMBIA RIVER; ENTOSPHENUS-TRIDENTATUS; ACOUSTIC CAMERA; BEHAVIOR; SALMON; PRECISION; MIGRATION; ABUNDANCE; ACCURACY; PASSAGE AB Dual-frequency Identification Sonar (DIDSON) is increasingly used as a fish monitoring and enumeration tool, but many studies do not evaluate potential observer biases. In this project, we assessed inter-observer differences in the identification and enumeration of adult Pacific lamprey (Entosphenus tridentatus) imaged with DIDSON passing a large dam fishway. Six trained viewers independently identified lamprey observation 'events' in the same similar to 12 h of DIDSON data collected at several fishway locations using two sonar orientations. Among-viewer variability in lamprey enumeration was high and viewer agreement on individual lamprey was often low. A total of 274 unique potential Pacific lamprey events was identified, but individual viewers scored only 89-173 events each (mean = 131, CV = 24%) or 32-63% of the total. Viewer identification rates (events/h) varied several-fold at some sites which we attributed primarily to event non-detection rather than species misclassification. Identification differences were related to viewer confidence, image duration, total fish density, and sonar orientation. Among-viewer agreement was highest in standard-orientation deployments lateral to the swimming lamprey, where images appeared as though acquired from overhead. Imagery in standard orientation had longer event duration and enhanced detection of anguilliform swimming, the most important characteristic for distinguishing Pacific lamprey from other species. Lamprey events observed in rolled orientation (sonar rotated 90 degrees) tended to be short duration with foreshortened head-or tail-first images that reduced viewer confidence. Our results highlight the importance of quality control assessments in acoustic imaging studies, especially those targeting cryptic species and those conducted in hydraulically challenging, multi-species environments. C1 [Keefer, Matthew L.; Caudill, Christopher C.; Johnson, Eric L.; Clabough, Tami S.; Boggs, Charles T.] Univ Idaho, Coll Nat Resources, Dept Fish & Wildlife Sci, 875 Perimeter Dr, Moscow, ID 83844 USA. [Johnson, Peter N.] LGL Alaska Res Associates Inc, 192 Roosevelt St,POB 771, Stevenson, WA 98648 USA. [Nagy, William T.] US Army Corps Engineers, Fisheries Field Unit, POB 150, Cascade Locks, OR USA. RP Keefer, ML (reprint author), Univ Idaho, Coll Nat Resources, Dept Fish & Wildlife Sci, 875 Perimeter Dr, Moscow, ID 83844 USA. EM mkeefer@uidaho.edu FU U.S. Army Corps of Engineers, Portland District FX This research was financed by the U.S. Army Corps of Engineers, Portland District and was facilitated by S. Tackley. We would like to thank J. Rerecich, T. Mackey, M. Zyndol, J. Dalen and U.S. Army Corp of Engineers staff at Bonneville Dam. R. Budwig and R. Basham (University of Idaho Center for Ecohydraulics Research) designed and manufactured some of the DIDSON deployment systems. T. Dick, D. Joosten, M. NR 40 TC 0 Z9 0 U1 0 U2 0 PU NORTHWEST SCIENTIFIC ASSOC PI SEATTLE PA JEFFREY DUDA, USGS, WESTERN FISHERIES RES CTR, 6505 NE 65 ST, SEATTLE, WA 98115 USA SN 0029-344X EI 2161-9859 J9 NORTHWEST SCI JI Northwest Sci. PD JAN PY 2017 VL 91 IS 1 BP 41 EP 53 PG 13 WC Ecology SC Environmental Sciences & Ecology GA EM2SB UT WOS:000395164800005 ER PT J AU Ashton, NK Liss, SA Walker, RW Brown, RS Klassen, C Backhouse, S Bates, P Townsend, RL AF Ashton, Neil K. Liss, Stephanie A. Walker, Ricardo W. Brown, Richard S. Klassen, Cheryl Backhouse, Stephanie Bates, Phil Townsend, Richard L. TI How Low Can You Go? Determining a Size Threshold for Implantation of a New Acoustic Transmitter in Age-0 White Sturgeon SO NORTHWEST SCIENCE LA English DT Article DE behavior; juvenile sturgeon; movement; size-dependent effects; telemetry ID JUVENILE CHINOOK SALMON; ACIPENSER-FULVESCENS RAFINESQUE; LAKE STURGEON; SWIMMING PERFORMANCE; SHORTNOSE STURGEON; KOOTENAI RIVER; COLUMBIA RIVER; GROWTH; SURVIVAL; TRANSMONTANUS AB Telemetry studies are often used to investigate sturgeon habitat use and movement patterns; however, existing acoustic transmitters are generally too large to implant into age-0 sturgeon without harming the fish. Recent development of a miniaturized acoustic transmitter (cylindrical, 0.7 g in air, 24.2 mm long, 5.0 mm diameter) with up to 365 d battery life has the potential to advance our understanding of age-0 sturgeon ecology in rivers and lakes. Prior to use in field studies, it is essential to conduct experiments evaluating potential adverse transmitter effects on fish. We tested transmitter retention, fish survival, and growth of a broad size range of age-0 white sturgeon (Acipenser transmontanus; 158-277 mm fork length; 26-126 g; 0.6-2.6% transmitter burden) in an 84 d laboratory study, with an ultimate goal of determining a minimum size threshold of sturgeon that can be implanted with this acoustic transmitter. At 84 d post-implantation, transmitter retention and fish survival were 100%. Specific growth rates were reduced at 7 and 14 d post-implantation, resulting in minimum fork length thresholds of 250 and 171 mm, respectively. Juveniles implanted with transmitters regained their growth potential by 28 d post-implantation and no size differences were detected in comparisons with unmarked control fish. This study demonstrates the ability to implant small age-0 sturgeon with high transmitter retention and fish survival, and only minor growth effects. Use of new miniaturized acoustic transmitters may give researchers a means to address questions about young-of-the-year fish recruitment, ecological patterns, and potentially advance conservation management of sturgeon populations. C1 [Ashton, Neil K.; Liss, Stephanie A.; Walker, Ricardo W.; Brown, Richard S.] Pacific Northwest Natl Lab, 902 Battelle Blvd POB 999, Richland, WA 99354 USA. [Klassen, Cheryl; Backhouse, Stephanie] Manitoba Hydro, 19 Henlow Bay, Winnipeg, MB R3Y 1G4, Canada. [Bates, Phil] Idaho Power Co, 1221 W Idaho St, Boise, ID 83702 USA. [Townsend, Richard L.] Univ Washington, 1410 NE Campus Pkwy,POB 355852, Seattle, WA 98195 USA. [Ashton, Neil K.] Univ Idaho, 709 S Deakin St, Moscow, ID 83844 USA. [Walker, Ricardo W.] US Army Corps Engineers, 333 SW 1st Ave 200, Portland, OR 97204 USA. RP Liss, SA (reprint author), Pacific Northwest Natl Lab, 902 Battelle Blvd POB 999, Richland, WA 99354 USA. EM stephanie.liss@pnnl.gov FU Manitoba Hydro; Idaho Power Company; Laboratory Directed Research and Development Program at the Pacific Northwest National Laboratory (PNNL) FX We thank Manitoba Hydro, Idaho Power Company, and the Laboratory Directed Research and Development Program at the Pacific Northwest National Laboratory (PNNL) for funding support. We would also like to thank the Washington Department of Fish and Wildlife Columbia Basin Hatchery for providing us with sturgeon and PNNL staff who were instrumental in this study: Z. Daniel Deng and Huidong Li for acoustic transmitter development, Tim Linley for his assistance in fish husbandry and laboratory use, and Jill Janak, Sadie Montgomery, Jose Vasquez, Ethan Green, and Erika Cutsforth for their assistance with implantation. NR 38 TC 0 Z9 0 U1 0 U2 0 PU NORTHWEST SCIENTIFIC ASSOC PI SEATTLE PA JEFFREY DUDA, USGS, WESTERN FISHERIES RES CTR, 6505 NE 65 ST, SEATTLE, WA 98115 USA SN 0029-344X EI 2161-9859 J9 NORTHWEST SCI JI Northwest Sci. PD JAN PY 2017 VL 91 IS 1 BP 69 EP 80 PG 12 WC Ecology SC Environmental Sciences & Ecology GA EM2SB UT WOS:000395164800007 ER PT J AU Capo-Aponte, JE Jorgensen-Wagers, KL Sosa, JA Walsh, DV Goodrich, GL Temme, LA Riggs, DW AF Capo-Aponte, Jose E. Jorgensen-Wagers, Kendra L. Sosa, Josue A. Walsh, David V. Goodrich, Gregory L. Temme, Leonard A. Riggs, Daniel W. TI Visual Dysfunctions at Different Stages after Blast and Non-blast Mild Traumatic Brain Injury SO OPTOMETRY AND VISION SCIENCE LA English DT Article DE visual dysfunction; mild traumatic brain injury; mTBI; military; blast ID POSTCONCUSSIVE SYMPTOMS; SUBACUTE STAGE; MODERATE; PROGRESSION; POPULATION; IMPAIRMENT; MECHANISMS; MILITARY; VETERANS; PROTOCOL AB Purpose. To assess the prevalence of visual dysfunctions and associated symptoms in war fighters at different stages after nonYblast- or blast-induced mild traumatic brain injury (mTBI). Methods. A comprehensive retrospective review of the electronic health records of 500 U.S. military personnel with a diagnosis of deployment-related mTBI who received eye care at the Landstuhl Regional Medical Center. For analysis, the data were grouped by mechanism of injury, and each group was further divided in three subgroups based on the number of days between injury and initial eye examination. Results. The data showed a high frequency of visual symptoms and visual dysfunctions. However, the prevalence of visual symptoms and visual dysfunctions did not differ significantly between mechanism of injury and postinjury stage, except for eye pain and diplopia. Among visual symptoms, binocular dysfunctions were more common, including higher near vertical phoria, reduced negative fusional vergence break at near, receded near point of convergence, decreased stereoacuity, and reduced positive relative accommodation. Conclusions. The lack of difference in terms of visual sequelae between subgroups (blast vs. nonblast) suggests that research addressing the assessment and management of mTBI visual sequelae resulting from civilian nonblast events is relevant to military personnel where combat injury results primarily from a blast event. C1 [Capo-Aponte, Jose E.; Sosa, Josue A.; Walsh, David V.; Temme, Leonard A.; Riggs, Daniel W.] US Army, Visual Sci Branch, Sensory Res Div, Aeromed Res Lab, Ft Rucker, AL USA. [Capo-Aponte, Jose E.] Womack Army Med Ctr, Dept Optometry, 2817 Reilly Rd Stop A, Ft Bragg, NC 28310 USA. [Jorgensen-Wagers, Kendra L.] Landstuhl Reg Med Ctr, Traumat Brain Injury Clin, APO, Landstuhl, Germany. [Goodrich, Gregory L.] Veteran Affairs Palo Alto Hlth Care Syst, Psychol Serv, Menlo Pk, CA USA. [Goodrich, Gregory L.] Veteran Affairs Palo Alto Hlth Care Syst, Western Blind Rehabil Ctr, Menlo Pk, CA USA. RP Capo-Aponte, JE (reprint author), Womack Army Med Ctr, Dept Optometry, 2817 Reilly Rd Stop A, Ft Bragg, NC 28310 USA. EM jose.e.capoaponte.mil@mail.mil FU Postgraduate Research Participation Program at the U.S. Army Aeromedical Research Laboratory; U.S. Department of Energy; U.S. Army Medical Research and Materiel Command FX Sponsored in part by the appointment to the Postgraduate Research Participation Program at the U.S. Army Aeromedical Research Laboratory administered by the Oak Ridge Institute of Science and Education through an interagency agreement, the U.S. Department of Energy and the U.S. Army Medical Research and Materiel Command. NR 36 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1040-5488 EI 1538-9235 J9 OPTOMETRY VISION SCI JI Optom. Vis. Sci. PD JAN PY 2017 VL 94 IS 1 BP 7 EP 15 PG 9 WC Ophthalmology SC Ophthalmology GA EM5ZZ UT WOS:000395393900003 PM 26889821 ER PT J AU Owens, BD Cameron, KL Bokshan, SL Clifton, KB Svoboda, SJ Wolf, JM AF Owens, Brett D. Cameron, Kenneth L. Bokshan, Steven L. Clifton, Kari B. Svoboda, Steven J. Wolf, Jennifer Moriatis TI Serum Cartilage Biomarkers and Shoulder Instability SO ORTHOPEDICS LA English DT Article ID COLLAGEN TURNOVER; RISK-FACTORS; II COLLAGEN; ANTERIOR; OSTEOARTHRITIS; DISLOCATIONS AB Differences in cartilage biomarkers have been noted in patients with anterior cruciate ligament tears, but little is known about any similar relationship with shoulder instability. This study evaluated the relationship between serum cartilage biomarkers and shoulder instability. The authors present a prospective cohort study of young athletes followed from 2006 to 2010. A nested case-control analysis was conducted within this cohort to evaluate the association between preinjury collagen type II cleavage (a marker for type II collagen cleavage) and procollagen II carboxy propeptide (a marker of cartilage synthesis) and the subsequent likelihood of shoulder instability during the 4-year follow-up period. Preinjury collagen type II cleavage and procollagen II carboxy propeptide levels in 51 subjects who had shoulder instability were compared with levels in 210 subjects without documented anterior cruciate ligament or shoulder instability (control group) with commercially available enzyme-linked immunosorbent assay kits. Mean preinjury collagen type II cleavage levels in patients who subsequently had shoulder instability were significantly lower than those in the control group (73.91 vs 79.24 pg/mL, P=.03). No significant difference was found in preinjury procollagen II carboxy propeptide levels compared with the control group (359.94 vs 396.37, P=.24). This study is the first to examine the relationship between baseline collagen biomarkers and subsequent shoulder instability. The finding of lower baseline collagen type II cleavage levels in patients with subsequent shoulder instability may represent a genetic predisposition or a compensatory mechanism by which cartilage degradation is decreased in those who are more likely to have instability. C1 [Owens, Brett D.] Brown Univ, Warren Alpert Med Sch, Dept Orthopaed, Div Sports Med, 2 Dudley St, Providence, RI 02912 USA. [Cameron, Kenneth L.] Brown Univ, Warren Alpert Med Sch, Dept Orthopaed, Providence, RI USA. [Cameron, Kenneth L.; Svoboda, Steven J.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. [Clifton, Kari B.; Wolf, Jennifer Moriatis] Univ Connecticut, Farmington, CT USA. RP Owens, BD (reprint author), Brown Univ, Warren Alpert Med Sch, Dept Orthopaed, Div Sports Med, 2 Dudley St, Providence, RI 02912 USA. EM owensbrett@gmail.com FU Mitek; Conmed; Linvatec; MTF; Orthopaedic Research and Education Foundation FX Drs Cameron, Bokshan, Clifton, Svoboda, and Wolf have no relevant financial relationships to disclose. Dr Owens is a paid consultant for Mitek, Conmed, Linvatec, and MTF.; This study was supported by a Prospective Research Grant from the Orthopaedic Research and Education Foundation. NR 16 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 EI 1938-2367 J9 ORTHOPEDICS JI Orthopedics PD JAN-FEB PY 2017 VL 40 IS 1 BP 34 EP 36 DI 10.3928/01477447-20160926-04 PG 3 WC Orthopedics SC Orthopedics GA EP0MW UT WOS:000397082400036 ER PT J AU Briggs, MA Campbell, S Nolan, J Walvoord, MA Ntarlagiannis, D Day-Lewis, FD Lane, JW AF Briggs, Martin A. Campbell, Seth Nolan, Jay Walvoord, Michelle A. Ntarlagiannis, Dimitrios Day-Lewis, Frederick D. Lane, John W. TI Surface Geophysical Methods for Characterising Frozen Ground in Transitional Permafrost Landscapes SO PERMAFROST AND PERIGLACIAL PROCESSES LA English DT Article DE electromagnetic induction; electrical resistivity; geophysics; ground penetrating radar; thermal infrared; permafrost aggradation ID CLIMATE-CHANGE; DISCONTINUOUS PERMAFROST; ELECTROMAGNETIC DATA; PENETRATING RADAR; INTERIOR ALASKA; YUKON RIVER; LAKE; USA; RESILIENCE; RESOLUTION AB The distribution of shallow frozen ground is paramount to research in cold regions, and is subject to temporal and spatial changes influenced by climate, landscape disturbance and ecosystem succession. Remote sensing from airborne and satellite platforms is increasing our understanding of landscape-scale permafrost distribution, but typically lacks the resolution to characterise finer-scale processes and phenomena, which are better captured by integrated surface geophysical methods. Here, we demonstrate the use of electrical resistivity imaging (ERI), electromagnetic induction (EMI), ground penetrating radar (GPR) and infrared imaging over multiple summer field seasons around the highly dynamic Twelvemile Lake, Yukon Flats, central Alaska, USA. Twelvemile Lake has generally receded in the past 30yr, allowing permafrost aggradation in the receded margins, resulting in a mosaic of transient frozen ground adjacent to thick, older permafrost outside the original lakebed. ERI and EMI best evaluated the thickness of shallow, thin permafrost aggradation, which was not clear from frost probing or GPR surveys. GPR most precisely estimated the depth of the active layer, which forward electrical resistivity modelling indicated to be a difficult target for electrical methods, but could be more tractable in time-lapse mode. Infrared imaging of freshly dug soil pit walls captured active-layer thermal gradients at unprecedented resolution, which may be useful in calibrating emerging numerical models. GPR and EMI were able to cover landscape scales (several kilometres) efficiently, and new analysis software showcased here yields calibrated EMI data that reveal the complicated distribution of shallow permafrost in a transitional landscape. Copyright (c) 2016 John Wiley & Sons, Ltd. C1 [Briggs, Martin A.; Day-Lewis, Frederick D.; Lane, John W.] US Geol Survey, Off Groundwater, Branch Geophys, 11 Sherman Pl,Unit 5015, Storrs, CT 06269 USA. [Campbell, Seth] Cold Reg Res & Engn Lab, Hanover, NH USA. [Nolan, Jay; Ntarlagiannis, Dimitrios] Rutgers State Univ, Dept Earth & Environm Sci, Newark, NJ USA. [Walvoord, Michelle A.] US Geol Survey, Natl Res Program, Denver Fed Ctr, Box 25046, Denver, CO 80225 USA. RP Briggs, MA (reprint author), US Geol Survey, Off Groundwater, Branch Geophys, 11 Sherman Pl,Unit 5015, Storrs, CT 06269 USA. EM mbriggs@usgs.gov FU Strategic Environmental Research and Development Program [RC-2111]; USGS Office of Groundwater; USGS National Research Program; USGS Groundwater Resources Program FX We thank Stephanie Saari, Emily Voytek, Heather Best, Doug Halm and Eric White for assistance in the field and in the processing of data. The manuscript was improved through journal review and by thorough feedback from Josh Koch. Funding for this project was provided by the Strategic Environmental Research and Development Program (award RC-2111), with additional support from the USGS Office of Groundwater, the USGS National Research Program and the USGS Groundwater Resources Program. Any use of trade, firm or product names is for descriptive purposes only and does not imply endorsement by the US Government. NR 37 TC 2 Z9 2 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1045-6740 EI 1099-1530 J9 PERMAFROST PERIGLAC JI Permafrost Periglacial Process. PD JAN-MAR PY 2017 VL 28 IS 1 BP 52 EP 65 DI 10.1002/ppp.1893 PG 14 WC Geography, Physical; Geology SC Physical Geography; Geology GA EL2DI UT WOS:000394429900005 ER PT J AU Brunye, TT Wood, MD Houck, LA Taylor, HA AF Brunye, Tad T. Wood, Matthew D. Houck, Lindsay A. Taylor, Holly A. TI The path more travelled: Time pressure increases reliance on familiar route-based strategies during navigation SO QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY LA English DT Article DE Spatial cognition; Navigation; Time pressure; Decision making ID RESPONSE LEARNING-STRATEGIES; DECLARATIVE MEMORY; DECISION-MAKING; SPATIAL MEMORY; EXECUTIVE CONTROL; COGNITIVE MAP; HUMANS; HIPPOCAMPUS; SYSTEMS; KNOWLEDGE AB Navigating large-scale environments involves dynamic interactions between the physical world and individuals' knowledge, goals, and strategies. Time pressure can result from self-imposed goals or relatively dynamic situational factors that induce varied constraints. While time pressure is ubiquitous in daily life and has been shown to influence affective states, cost-benefit analyses, and strategy selection, its influence on navigation behaviour is unknown. The present study examined how introducing varied time constraints during virtual urban navigation would influence spatial strategies and impact the efficiency and effectiveness of goal-directed wayfinding. Participants learned a large-scale urban virtual environment by wayfinding between a series of 20 successive landmark goals (e.g., You have reached the Theater. Now find the Bank.). A day later, they again performed the same task, but landmark-to-landmark trials were characterized by conditions of low-, moderate-, or high-pressure time limits as quantified by a pilot experiment. As time pressure increased, participants more likely navigated along previously experienced paths and less likely travelled in the global direction of the destination. Results suggest strategy shifts under time constraints that increase reliance on egocentric, route-based strategies and decrease reliance on global configural knowledge, probably in an attempt to reduce cognitive demands and support performance under pressure. C1 [Brunye, Tad T.; Houck, Lindsay A.; Taylor, Holly A.] Ctr Appl Brain & Cognit Sci, 200 Boston Ave,Suite 3000, Medford, MA 02155 USA. [Brunye, Tad T.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.; Houck, Lindsay A.] US Army Natick Soldier Res Dev & Engn Ctr, Cognit Sci Team, Natick, MA USA. [Wood, Matthew D.] US Army Corps Engineers, Risk & Decis Sci, US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Brunye, TT (reprint author), Ctr Appl Brain & Cognit Sci, 200 Boston Ave,Suite 3000, Medford, MA 02155 USA. EM tbruny01@tufts.edu FU U.S. Army Natick Soldier Research, Development, and Engineering Center (U.S. Army Materiel Command) [W911QY-13-C-0012] FX This work was supported by a grant awarded to H.A.T. from the U.S. Army Natick Soldier Research, Development, and Engineering Center (U.S. Army Materiel Command) [grant number W911QY-13-C-0012]. Permission was granted by the U.S. Army to publish this material. The views expressed in this article are solely those of the authors and do not reflect the official policies or positions of the Department of the Army, the Department of Defense, or any other department or agency of the U.S. government. NR 64 TC 0 Z9 0 U1 2 U2 2 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1747-0218 EI 1747-0226 J9 Q J EXP PSYCHOL JI Q. J. Exp. Psychol. PY 2017 VL 70 IS 8 BP 1439 EP 1452 DI 10.1080/17470218.2016.1187637 PG 14 WC Psychology, Biological; Physiology; Psychology; Psychology, Experimental SC Psychology; Physiology GA EO6UW UT WOS:000396829000002 PM 27156528 ER PT J AU Smith, R AF Smith, Roger TI The 21st-Century Printing Press SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Article C1 [Smith, Roger] Florida Hosp, Nicholson Ctr Surg Adv, Orlando, FL 32803 USA. [Smith, Roger] US Army Simulat, Orlando, FL USA. [Smith, Roger] Titan Corp, San Diego, CA USA. [Smith, Roger] BTG Inc, Jacksonville, FL USA. RP Smith, R (reprint author), Florida Hosp, Nicholson Ctr Surg Adv, Orlando, FL 32803 USA. EM roger.smith@flhosp.org NR 0 TC 0 Z9 0 U1 0 U2 0 PU INDUSTRIAL RESEARCH INST, INC PI ARLINGTON PA 2300 CLARENDON BLVD, STE 400, ARLINGTON, VA 22201 USA SN 0895-6308 EI 1930-0166 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD JAN-FEB PY 2017 VL 60 IS 1 BP 57 EP 59 DI 10.1080/08956308.2017.1255061 PG 3 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA EL2IO UT WOS:000394443500012 ER PT J AU Bucher, G AF Bucher, Greta TI One Day We Will Live without Fear: Everyday Lives under the Soviet Police State SO RUSSIAN REVIEW LA English DT Book Review C1 [Bucher, Greta] US Mil Acad, West Point, NY 10996 USA. RP Bucher, G (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0036-0341 EI 1467-9434 J9 RUSS REV JI Russ. Rev. PD JAN PY 2017 VL 76 IS 1 BP 183 EP 183 PG 1 WC History SC History GA EO0GB UT WOS:000396375200052 ER PT J AU Sherlock, T AF Sherlock, Thomas TI Building an Authoritarian Polity: Russia in Post-Soviet Times SO RUSSIAN REVIEW LA English DT Book Review C1 [Sherlock, Thomas] US Mil Acad, West Point, NY 10996 USA. RP Sherlock, T (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0036-0341 EI 1467-9434 J9 RUSS REV JI Russ. Rev. PD JAN PY 2017 VL 76 IS 1 BP 192 EP 194 PG 3 WC History SC History GA EO0GB UT WOS:000396375200061 ER PT J AU Finan, PH Quartana, PJ Remeniuk, B Garland, EL Rhudy, JL Hand, M Irwin, MR Smith, MT AF Finan, Patrick H. Quartana, Phillip J. Remeniuk, Bethany Garland, Eric L. Rhudy, Jamie L. Hand, Matthew Irwin, Michael R. Smith, Michael T. TI Partial Sleep Deprivation Attenuates the Positive Affective System: Effects Across Multiple Measurement Modalities SO SLEEP LA English DT Article DE sleep; affect; emotion; pain; depression; attention ID SLOW-WAVE SLEEP; CHRONIC PAIN; EMOTIONAL MODULATION; SPINAL NOCICEPTION; YOUNG-ADULTS; ATTENTION; INSOMNIA; DEPRESSION; FIBROMYALGIA; MAINTENANCE AB Objective: Ample behavioral and neurobiological evidence links sleep and affective functioning. Recent self-report evidence suggests that the affective problems associated with sleep loss may be stronger for positive versus negative affective state and that those effects may be mediated by changes in electroencepholographically measured slow wave sleep (SWS). In the present study, we extend those preliminary findings using multiple measures of affective functioning. Design: In a within-subject randomized crossover experiment, we tested the effects of one night of sleep continuity disruption via forced awakenings (FA) compared to one night of uninterrupted sleep (US) on three measures of positive and negative affective functioning: self-reported affective state, affective pain modulation, and affect-biased attention. Setting: The study was set in an inpatient clinical research suite. Participants: Healthy, good sleeping adults (N = 45) were included. Measurement and Results: Results indicated that a single night of sleep continuity disruption attenuated positive affective state via FA-induced reductions in SWS. Additionally, sleep continuity disruption attenuated the inhibition of pain by positive affect as well as attention bias to positive affective stimuli. Negative affective state, negative affective pain facilitation, nor negative attention bias were altered by sleep continuity disruption. Conclusions: The present findings, observed across multiple measures of affective function, suggest that sleep continuity disruption has a stronger influence on the positive affective system relative to the negative affective affective system. C1 [Finan, Patrick H.; Remeniuk, Bethany; Hand, Matthew; Smith, Michael T.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 5510 Nathan Shock Dr,Suite 100, Baltimore, MD 21224 USA. [Quartana, Phillip J.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Garland, Eric L.] Univ Utah, Coll Social Work, Salt Lake City, UT USA. [Garland, Eric L.] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA. [Rhudy, Jamie L.] Univ Tulsa, Dept Psychol, Tulsa, OK 74104 USA. [Irwin, Michael R.] Univ Calif Los Angeles, Semel Inst Neurosci, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA USA. RP Finan, PH (reprint author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 5510 Nathan Shock Dr,Suite 100, Baltimore, MD 21224 USA. EM pfinan1@jhu.edu FU NIH [K23 DA035915, P30 NR014131, T32 NS7020110, R34 DA037005, R01 DA0329922] FX The work was performed at Johns Hopkins University School of Medicine. Financial Support was provided by NIH K23 DA035915 and NIH P30 NR014131 (PHF); NIH T32 NS7020110 (BR); NIH R34 DA037005 (ELG); NIH R01 DA0329922 (MTS, MRI). NR 59 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0161-8105 EI 1550-9109 J9 SLEEP JI Sleep PD JAN 1 PY 2017 VL 40 IS 1 AR PII zsw017 DI 10.1093/sleep/zsw017 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA EK7SO UT WOS:000394125700017 ER PT J AU Johnson, DA Simonelli, G Moore, K Billings, M Mujahid, MS Rueschman, M Kawachi, I Redline, S Roux, AVD Patel, SR AF Johnson, Dayna A. Simonelli, Guido Moore, Kari Billings, Martha Mujahid, Mahasin S. Rueschman, Michael Kawachi, Ichiro Redline, Susan Roux, Ana V. Diez Patel, Sanjay R. TI The Neighborhood Social Environment and Objective Measures of Sleep in the Multi-Ethnic Study of Atherosclerosis SO SLEEP LA English DT Article DE Neighborhoods; sleep duration; sleep timing; actigraphy ID LONGITUDINAL ASSOCIATIONS; SOCIOECONOMIC-STATUS; GLYCEMIC CONTROL; MENTAL-HEALTH; DURATION; NOISE; FRAGMENTATION; ADOLESCENTS; CHRONOTYPE; STRESSORS AB Study objectives: To investigate cross-sectional associations of neighborhood social environment (social cohesion, safety) with objective measures of sleep duration, timing, and disturbances. Methods: A racially/ethnically diverse population of men and women (N = 1949) aged 54 to 93 years participating in the Multi-Ethnic Study of Atherosclerosis Sleep and Neighborhood Ancillary studies. Participants underwent 1-week actigraphy between 2010 and 2013. Measures of sleep duration, timing, and disruption were averaged over all days. Neighborhood characteristics were assessed via questionnaires administered to participants and an independent sample within the same neighborhood and aggregated at the neighborhood (census tract, N = 783) level using empirical Bayes estimation. Multilevel linear regression models were used to assess the association between the neighborhood social environment and each sleep outcome. Results: Neighborhood social environment characterized by higher levels of social cohesion and safety were associated with longer sleep duration and earlier sleep midpoint. Each 1 standard deviation higher neighborhood social environment score was associated with 6.1 minutes longer [95% confidence interval (CI): 2.0, 10.2] sleep duration and 6.4 minutes earlier (CI: 2.2, 10.6) sleep midpoint after adjustment for age, sex, race, socioeconomic status, and marital status. These associations persisted after adjustment for other risk factors. Neighborhood social factors were not associated with sleep efficiency or sleep fragmentation index. Conclusions: A more favorable neighborhood social environment is associated with longer objectively measured sleep duration and earlier sleep timing. Intervening on the neighborhood environment may improve sleep and subsequent health outcomes. C1 [Johnson, Dayna A.; Rueschman, Michael; Redline, Susan; Patel, Sanjay R.] Brigham & Womens Hosp, Div Sleep & Circadian Disorders, 221 Longwood Ave BLI-225, Boston, MA 02115 USA. [Johnson, Dayna A.; Redline, Susan] Harvard Med Sch, Div Sleep Med, Boston, MA USA. [Simonelli, Guido] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. [Moore, Kari; Roux, Ana V. Diez] Drexel Univ, Dornsife Sch Publ Hlth, Urban Hlth Collaborat, Philadelphia, PA 19104 USA. [Billings, Martha] Univ Washington, Div Pulm Crit Care, Med Sleep Ctr, Seattle, WA 98195 USA. [Mujahid, Mahasin S.] Univ Calif Berkeley, Div Epidemiol, Berkeley, CA 94720 USA. [Kawachi, Ichiro] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA. [Patel, Sanjay R.] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA. RP Johnson, DA (reprint author), Brigham & Womens Hosp, Div Sleep & Circadian Disorders, 221 Longwood Ave BLI-225, Boston, MA 02115 USA. EM djohnson@research.bwh.harvard.edu FU National Heart, Lung, and Blood Institute [HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, R01 HL071759, R01 HL098433]; NCRR [UL1-TR-000040, UL1-TR-001079]; National Heart, Lung, And Blood Institute of the National Institutes of Health [R01HL110068]; NRC research associateship program; [HL127307] FX This research was supported by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, R01 HL071759, and R01 HL098433 from the National Heart, Lung, and Blood Institute and by grants UL1-TR-000040 and UL1-TR-001079 from NCRR. Dr. Johnson was supported by The National Heart, Lung, And Blood Institute of the National Institutes of Health (R01HL110068). Dr. Simonelli was supported by the NRC research associateship program. Dr. Patel was supported by HL127307. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org. NR 61 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0161-8105 EI 1550-9109 J9 SLEEP JI Sleep PD JAN 1 PY 2017 VL 40 IS 1 AR PII zsw016 DI 10.1093/sleep/zsw016 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA EK7SO UT WOS:000394125700016 ER PT J AU Simonelli, G Dudley, KA Weng, J Gallo, LC Perreira, K Shah, NA Alcantara, C Zee, PC Ramos, AR Llabre, MM Sotres-Alvarez, D Wang, R Patel, SR AF Simonelli, Guido Dudley, Katherine A. Weng, Jia Gallo, Linda C. Perreira, Krista Shah, Neomi A. Alcantara, Carmela Zee, Phyllis C. Ramos, Alberto R. Llabre, Maria M. Sotres-Alvarez, Daniela Wang, Rui Patel, Sanjay R. TI Neighborhood Factors as Predictors of Poor Sleep in the Sueno Ancillary Study of the Hispanic Community Health Study/Study of Latinos SO SLEEP LA English DT Article DE sleep; insomnia; neighborhood; safety; noise; actigraphy ID ROAD TRAFFIC NOISE; INSOMNIA SEVERITY INDEX; PSYCHOLOGICAL DISTRESS; DEPRESSIVE SYMPTOMS; DIVERSE BACKGROUNDS; ANXIETY DISORDERS; UNITED-STATES; RISK-FACTORS; SHORT-FORM; CES-D AB Study Objectives: To evaluate whether an adverse neighborhood environment has higher prevalence of poor sleep in a US Hispanic/Latino population. Methods: A cross-sectional analysis was performed in 2156 US Hispanic/Latino participants aged 18-64 years from the Sueno ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Participants completed surveys of neighborhood environment including perceived safety, violence and noise, the Insomnia Severity Index (ISI), and 7 days of wrist actigraphy. Results: In age and sex-adjusted analyses, short sleep, low sleep efficiency, and late sleep midpoint were all more prevalent among those living in an unsafe neighborhood. After adjustment for background, site, nativity, income, employment, depressive symptoms, and sleep apnea, the absolute risk of sleeping < 6 hours was 7.7 (95% CI [0.9, 14.6]) percentage points greater in those living in an unsafe compared to a safe neighborhood. There were no differences in the prevalence of insomnia by level of safety or violence. Insomnia was more prevalent among those living in a noisy neighborhood. In adjusted analysis, the absolute risk of insomnia was 4.4 (95% CI [0.4, 8.4]) percentage points greater in those living in noisy compared to non-noisy neighborhoods. Conclusion: Using validated measures of sleep duration and insomnia, we have demonstrated the existence of a higher prevalence of short sleep and insomnia by adverse neighborhood factors. An adverse neighborhood environment is an established risk factor for a variety of poor health outcomes. Our findings suggest negative effects on sleep may represent one pathway by which neighborhood environment influences health. C1 [Simonelli, Guido] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA. [Dudley, Katherine A.] Beth Israel Deaconess Med Ctr, Div Pulm Crit Care & Sleep Med, Boston, MA 02215 USA. [Weng, Jia; Wang, Rui] Brigham & Womens Hosp, Div Sleep & Circadian Disorders, 75 Francis St, Boston, MA 02115 USA. [Gallo, Linda C.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA. [Perreira, Krista] Univ N Carolina, Dept Publ Policy, Chapel Hill, NC USA. [Shah, Neomi A.] Icahn Sch Med Mt Sinai, Div Pulm Crit Care & Sleep, New York, NY 10029 USA. [Alcantara, Carmela] Columbia Univ, Sch Social Work, New York, NY USA. [Zee, Phyllis C.] Northwestern Univ, Feinberg Sch Med, Ctr Circadian & Sleep Med, Evanston, IL USA. [Ramos, Alberto R.] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA. [Llabre, Maria M.] Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA. [Sotres-Alvarez, Daniela] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Biostat, Collaborat Studies Coordinating Ctr, Chapel Hill, NC USA. [Patel, Sanjay R.] Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, NW MUH 628,3459 Fifth Ave, Pittsburgh, PA 15213 USA. RP Patel, SR (reprint author), Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, NW MUH 628,3459 Fifth Ave, Pittsburgh, PA 15213 USA. EM patelsr2@upmc.edu FU National Heart, Lung, and Blood Institute (NHLBI) [HL098297, HL127307]; NHLBI [N01-HC65233]; University of Miami [N01-HC65234]; Albert Einstein College of Medicine [N01-HC65235]; Northwestern University [N01-HC65236]; San Diego State University [N01-HC65237]; NHLBI: National Center on Minority Health and Health Disparities; National Institute of Deafness and Other Communications Disorders; National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; Office of Dietary Supplements FX This work was supported by National Heart, Lung, and Blood Institute (NHLBI) (HL098297) and (HL127307). In addition, HCHS/SOL was carried out as a collaborative study supported by contracts from NHLBI to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements. NR 80 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0161-8105 EI 1550-9109 J9 SLEEP JI Sleep PD JAN 1 PY 2017 VL 40 IS 1 AR PII zsw025 DI 10.1093/sleep/zsw025 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA EK7SO UT WOS:000394125700025 ER PT J AU Barth, NA Villarini, G Nayak, MA White, K AF Barth, Nancy A. Villarini, Gabriele Nayak, Munir A. White, Kathleen TI Mixed populations and annual flood frequency estimates in the western United States: The role of atmospheric rivers SO WATER RESOURCES RESEARCH LA English DT Article DE mixed populations; atmospheric rivers; flood frequency; western United States ID INLAND PENETRATION; SIERRA-NEVADA; PRECIPITATION; COAST; SCALE; CALIFORNIA; SEASON; FLOWS; DAMS AB The Bulletin 17B framework assumes that the annual peak flow data included in a flood frequency analysis are from a homogeneous population. However, flood frequency analysis over the western United States is complicated by annual peak flow records that frequently contain annual flows generated from distinctly different flood generating mechanisms. These flood series contain multiple zero flows and/or potentially influential low floods (PILFs) that substantially deviate from the overall pattern in the data. Moreover, they often also contain extreme flood events representing different hydrometeorologic agents. Among the different flood generating mechanisms, atmospheric rivers (ARs) are responsible for large, regional-scale floods. The spatial and fractional contribution of ARs in annual peak flow data is examined based on 1375 long-term U.S. Geological Survey (USGS) streamgage sites with at least 30 years of data. Six main areas in which flooding is impacted by ARs at varying degrees were found throughout the western United States. The Pacific Northwest and the northern California coast have the highest fraction of AR-generated peaks (similar to 80-100%), while eastern Montana, Wyoming, Utah, Colorado, and New Mexico have nearly no impacts from ARs. The individual regions of the central Columbia River Basin in the Pacific Northwest, the Sierra Nevada, the central and southern California coast, and central Arizona all show a mixture of 30-70% AR-generated flood peaks. Analyses related to the largest flood peaks on record and to the estimated annual exceedance probabilities highlight the strong impact of ARs on flood hydrology in this region, together with marked regional differences. C1 [Barth, Nancy A.; Villarini, Gabriele; Nayak, Munir A.] Univ Iowa, IIHR Hydrosci & Engn, Iowa City, IA 52242 USA. [White, Kathleen] US Army Corps Engineers, Inst Water Resources, Alexandria, VA USA. RP Villarini, G (reprint author), Univ Iowa, IIHR Hydrosci & Engn, Iowa City, IA 52242 USA. EM gabriele-villarini@uiowa.edu OI Villarini, Gabriele/0000-0001-9566-2370; Nayak, Munir/0000-0003-2764-3623 FU U.S. Army Corps of Engineers (USACE) Research; ORAU under DOE [DE-AC05-06OR23100]; USACE Institute for Water Resources; National Science Foundation under CAREER [AGS-1349827]; NASA Headquarters under the NASA Earth and Space Science Fellowship Program [NNX14AK78H] FX Nancy Barth was supported by an appointment to the U.S. Army Corps of Engineers (USACE) Research Participation Program administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy (DOE) and the U. S. Army Corps of Engineers (USACE). ORISE is managed by ORAU under DOE contract DE-AC05-06OR23100. All opinions expressed in this paper are the author's and do not necessarily reflect the policies and views of USACE, DOE, or ORAU/ORISE. Gabriele Villarini acknowledges financial support from the USACE Institute for Water Resources and funding by the National Science Foundation under CAREER Grant AGS-1349827. Munir A. Nayak was supported by NASA Headquarters under the NASA Earth and Space Science Fellowship Program, grant NNX14AK78H. The data used for these analyses are available from http://waterdata.usgs.gov/nwis and from http://www.esrl.noaa.gov/psd/data/gridded/data. 20thC_ReanV2c.html. The comments and suggestions by five anonymous reviewers and the Associate Editor are gratefully acknowledged. NR 43 TC 1 Z9 1 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 EI 1944-7973 J9 WATER RESOUR RES JI Water Resour. Res. PD JAN PY 2017 VL 53 IS 1 BP 257 EP 269 DI 10.1002/2016WR019064 PG 13 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA EL9AJ UT WOS:000394911200015 ER PT J AU Waters, K Pandey, R Karna, SP AF Waters, Kevin Pandey, Ravindra Karna, Shashi P. TI Amino Acid Analogue-Conjugated BN Nanomaterials in a Solvated Phase: First Principles Study of Topology-Dependent Interactions with a Monolayer and a (5,0) Nanotube SO ACS OMEGA LA English DT Article ID BORON-NITRIDE NANOTUBES; WALLED CARBON NANOTUBES; NONCOVALENT FUNCTIONALIZATION; DISPERSION CORRECTION; ADSORPTION; SURFACE; CYTOCOMPATIBILITY; STABILITY; MOLECULES; GRAPHENE AB Using density functional theory and an implicit solvation model, the relationship between the topology of boron nitride (BN) nanomaterials and the protonated/deprotonated states of amino acid analogues is investigated. In the solvated phase, the calculated results show distinct "physisorbed versus chemisorbed" conditions for the analogues of arginine (Arg)- and aspartic acid (Asp)-conjugated BN nanomaterials, including a monolayer (ML) and a small-diameter zigzag nanotube (NT). Such a distinction does not depend on the functional groups of amino acids but rather depends on the curvature-induced interactions associated with the tubular configuration. Arg and Asp interact with the BNML to form physisorbed complexes irrespective of the state of the amino acids in the solvated phase. For the NT, Arg and Asp form chemisorbed complexes, and the distinct nature of bonds between the donor electron moieties of N-(Arg) and O-(Asp) and the boron of the tubular surface is revealed by the natural bond orbital analysis; stronger s-type bonds for the deprotonated conjugated complexes and slightly weaker p-type dominated bonds for the protonated conjugated complexes. The interaction of neutral Trp with BN nanomaterials results in physisorbed configurations through pi-stacking interactions with the indole ring of the Trp and BN nanomaterials. The calculated results form the basis for a theoretical study of more complex protein macromolecules interacting with nanomaterials under physiological conditions. C1 [Waters, Kevin; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Karna, Shashi P.] US Army, Res Lab, ATTN RDRL WM, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. RP Waters, K; Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM kwaters@mtu.edu; pandey@mtu.edu FU Army Research Office [W911NF-14-2-0088] FX Helpful discussions with Nabanita Saikia, Max Seel, Wil Slough, and Gaoxue Wang are acknowledged. RAMA and Superior, high-performance computing clusters at Michigan Technological University, were used to obtain the results presented in this article. This research was partially supported by the Army Research Office through grant number W911NF-14-2-0088. NR 49 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2470-1343 J9 ACS OMEGA JI ACS Omega PD JAN PY 2017 VL 2 IS 1 BP 76 EP 83 DI 10.1021/acsomega.6b00321 PG 8 WC Chemistry, Multidisciplinary SC Chemistry GA EN2TF UT WOS:000395862400009 ER PT J AU Gatewood, JR Price, CR AF Gatewood, James R. Price, Candice R. TI Utilizing Social Network Analysis to Study Communities of Women in Conflict Zones SO JOURNAL OF HUMANISTIC MATHEMATICS LA English DT Article ID WAR AB This article proposes to study the plight of women in conflict zones through the lens of social network analysis. We endorse the novel idea of building a social network within troubled regions to assist in understanding the structure of women's communities and identifying key individuals and groups that will help rebuild and empower the lives of women. Our main argument is that we can better understand the complexity of a society with quantitative measures using a network analysis approach. Given the foundation of this paper, one can develop a model that will represent the connections between women in these communities. This model can then support work aiming to help women in zones of conflict. C1 [Gatewood, James R.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Price, Candice R.] Univ San Diego, Dept Math, San Diego, CA 92110 USA. RP Gatewood, JR (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM gatewood.james@gmail.com; cprice@sandiego.edu NR 22 TC 0 Z9 0 U1 0 U2 0 PU CLAREMONT CENTER MATHEMATICAL SCIENCES PI CLAREMONT PA 610 N COLLEGE AVE, 228C, CLAREMONT, CA 91711 USA SN 2159-8118 J9 J HUMANIST MATH JI J. Humanist. Math. PD JAN PY 2017 VL 7 IS 1 BP 3 EP 21 PG 19 WC History & Philosophy Of Science SC History & Philosophy of Science GA EO1JN UT WOS:000396454800002 ER PT J AU Tofsted, DH AF Tofsted, David H. TI Short-exposure turbulence effects on the modulation transfer function of annular aperture optical systems SO OPTICAL ENGINEERING LA English DT Article DE atmospheric turbulence; atmospheric optics; image formation theory; modulation transfer function ID ATMOSPHERIC-TURBULENCE AB The results of recent analytical work performed to characterize the short-exposure blurring effects of path integrated optical turbulence for annular aperture systems is described using the modulation transfer function. Results presented here extend the circular case to the annular aperture problem involving a circularly symmetric central obscuration associated with telescope optics secondary mirrors. To enable this extension, adjustments to procedures that compute the tilt-variance and phase-tilt correlation effects are described, and the results are illustrated. A four-dimensionally parameterized function of turbulence strength, diffraction influence, angular frequency, and fractional central obscuration is given. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. C1 [Tofsted, David H.] US Army, Res Lab, ATTN RDRL CIE D, White Sands Missile Range, NM 88002 USA. RP Tofsted, DH (reprint author), US Army, Res Lab, ATTN RDRL CIE D, White Sands Missile Range, NM 88002 USA. EM david.h.tofsted.civ@mail.mil NR 18 TC 0 Z9 0 U1 0 U2 0 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD JAN PY 2017 VL 56 IS 1 AR 015105 DI 10.1117/1.OE.56.1.015105 PG 10 WC Optics SC Optics GA EO0LN UT WOS:000396389400066 ER PT J AU Shen, CW Wang, CP Sanghadasa, M Lin, LW AF Shen, Caiwei Wang, Chun-Ping Sanghadasa, Mohan Lin, Liwei TI Flexible micro-supercapacitors prepared using direct-write nanofibers SO RSC ADVANCES LA English DT Article ID GRAPHITE OXIDE-FILMS; ALL-SOLID-STATE; ON-CHIP; ELECTROCHEMICAL CAPACITORS; HIGH-PERFORMANCE; ENERGY-STORAGE; CARBON NANOTUBE; ELECTRODES; DEVICES; NANOPARTICLES AB Herein, wedemonstrated direct-write flexible micro-supercapacitors prepared by the near-field electrospinning of polypyrrole (PPy) nanofibers on a patterned metal electrode deposited on a flexible polymer substrate. The continuous porous nanofiber network with a pseudocapacitance effect greatly increases the capacitance and facilitates ion transport in the electrodes. The prototype based on the lab-synthesized PPy nanofibers shows a high capacitance of 0.48 mF cm(-2) when the total area of both electrodes and electrolyte is considered, and the performance is not affected when it is bent to different extents. The micro-supercapacitors were experimentally proved to be highly flexible with excellent electrochemical performance and cycling stability. Our approach is simple, versatile, and compatible with different substrates for the direct integration of energy storage devices in flexible microsystems. C1 [Shen, Caiwei; Lin, Liwei] Univ Calif Berkeley, Dept Mech Engn, 1113 Etcheverry Hall, Berkeley, CA 94720 USA. [Wang, Chun-Ping] Natl Tsing Hua Univ, Dept Power Mech Engn, Hsinchu, Taiwan. [Sanghadasa, Mohan] US Army, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL USA. RP Shen, CW (reprint author), Univ Calif Berkeley, Dept Mech Engn, 1113 Etcheverry Hall, Berkeley, CA 94720 USA. EM shencw10@berkeley.edu FU BSAC, Berkeley Sensor and Actuator Center; National Science Foundation Industry/ University Cooperative Research Center; US Army Aviation and Missile Research, Development and Engineering Center FX This work was supported in part by the BSAC, Berkeley Sensor and Actuator Center, the National Science Foundation Industry/University Cooperative Research Center, and the US Army Aviation and Missile Research, Development and Engineering Center. NR 40 TC 0 Z9 0 U1 0 U2 0 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2046-2069 J9 RSC ADV JI RSC Adv. PY 2017 VL 7 IS 19 BP 11724 EP 11731 DI 10.1039/c6ra28218k PG 8 WC Chemistry, Multidisciplinary SC Chemistry GA EN2VH UT WOS:000395867900065 ER PT J AU Weiskopf, RB Beliaev, AM Shander, A Guinn, NR Cap, AP Ness, PM Silverman, TA AF Weiskopf, Richard B. Beliaev, Andrei M. Shander, Aryeh Guinn, Nicole R. Cap, Andrew P. Ness, Paul M. Silverman, Toby A. TI Addressing the unmet need of life-threatening anemia with hemoglobin-based oxygen carriers SO TRANSFUSION LA English DT Editorial Material ID LIBERAL TRANSFUSION STRATEGY; SEVERE ISOVOLEMIC ANEMIA; RECOMBINANT HUMAN HEMOGLOBIN; DECLINE BLOOD-TRANSFUSION; NITRIC-OXIDE; MYOCARDIAL-ISCHEMIA; HEMORRHAGIC-SHOCK; ELECTROPHYSIOLOGICAL DIFFERENCES; COGNITIVE FUNCTION; RANDOMIZED-TRIALS C1 [Weiskopf, Richard B.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Beliaev, Andrei M.] Auckland City Hosp, Green Lane Cardiothorac Surg Unit, Auckland, New Zealand. [Shander, Aryeh] Duke Univ, Med Ctr, Dept Anesthesiol, Ctr Blood Conservat, Durham, NC 27710 USA. [Guinn, Nicole R.] Englewood Hosp & Med Ctr, Dept Anesthesiol Crit Care Med Pain Management &, Englewood, NJ USA. [Guinn, Nicole R.] Icahn Sch Med Mt Sinai, Med & Surg, New York, NY 10029 USA. [Cap, Andrew P.] US Army Inst Surg Res, JBSA Ft Sam Houston, TX USA. [Ness, Paul M.] Johns Hopkins Sch Med, Pathol, Med, Oncol, Baltimore, MD USA. [Silverman, Toby A.] Parexel Consulting, Bethesda, MD USA. RP Weiskopf, RB (reprint author), Univ Calif San Francisco, San Francisco, CA 94143 USA. EM rbw@TheWeiskopfGroup.com NR 54 TC 0 Z9 0 U1 0 U2 0 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 EI 1537-2995 J9 TRANSFUSION JI Transfusion PD JAN PY 2017 VL 57 IS 1 BP 207 EP 214 DI 10.1111/trf.13923 PG 8 WC Hematology SC Hematology GA EL2CU UT WOS:000394428500028 PM 27859328 ER PT J AU Murugan, M Ghoshal, A Walock, MJ Barnett, BD Pepi, MS Kerner, KA AF Murugan, Muthuvel Ghoshal, Anindya Walock, Michael J. Barnett, Blake D. Pepi, Marc S. Kerner, Kevin A. TI Sand particle-Induced deterioration of thermal barrier coatings on gas turbine blades SO ADVANCES IN AIRCRAFT AND SPACECRAFT SCIENCE LA English DT Article DE turbine blade coatings; thermal barrier coatings; sand particle glazing; gas turbine coating damage ID HIGH-TEMPERATURE ATTACK; GLASSY DEPOSITS; RESISTANT; DEGRADATION; GRADIENT; SPRAY AB Gas turbines operating in dusty or sandy environment polluted with micron-sized solid particles are highly prone to blade surface erosion damage in compressor stages and molten sand attack in the hot sections of turbine stages. Commercial/Military fixed-wing aircraft engines and helicopter engines often have to operate over sandy terrains in the middle eastern countries or in volcanic zones; on the other hand gas turbines in marine applications are subjected to salt spray, while the coal-burning industrial power generation turbines are subjected to fly-ash. The presence of solid particles in the working fluid medium has an adverse effect on the durability of these engines as well as performance. Typical turbine blade damages include blade coating wear, sand glazing, Calcia-Magnesia-Alumina-Silicate (CMAS) attack, oxidation, plugged cooling holes, all of which can cause rapid performance deterioration including loss of aircraft. The focus of this research work is to simulate particle-surface kinetic interaction on typical turbomachinery material targets using non-linear dynamic impact analysis. The objective of this research is to understand the interfacial kinetic behaviors that can provide insights into the physics of particle interactions and to enable leap ahead technologies in material choices and to develop sand-phobic thermal barrier coatings for turbine blades. This paper outlines the research efforts at the U.S Army Research Laboratory to come up with novel turbine blade multifunctional protective coatings that are sand-phobic, sand impact wear resistant, as well as have very low thermal conductivity for improved performance of future gas turbine engines. The research scope includes development of protective coatings for both nickel-based super alloys and ceramic matrix composites. C1 [Murugan, Muthuvel; Ghoshal, Anindya; Walock, Michael J.; Barnett, Blake D.; Pepi, Marc S.] US Army, Res Lab, Bldg 4603, Aberdeen Proving Ground, MD 21005 USA. [Kerner, Kevin A.] US Army, Aviat & Missile Res Dev & Engn Ctr, Aviat Dev Directorate, Bldg 401, Fort Eustis, VA 23604 USA. RP Murugan, M (reprint author), US Army, Res Lab, Bldg 4603, Aberdeen Proving Ground, MD 21005 USA. EM muthuvel.murugan.civ@mail.mil NR 19 TC 0 Z9 0 U1 0 U2 0 PU TECHNO-PRESS PI DAEJEON PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA SN 2287-528X EI 2287-5271 J9 ADV AIRCR SPACECR SC JI Adv. Aircr. Spacecr. Sci. PD JAN PY 2017 VL 4 IS 1 BP 37 EP 52 DI 10.12989/aas.2017.4.1.037 PG 16 WC Engineering, Aerospace SC Engineering GA EM3XI UT WOS:000395247500003 ER PT J AU DeGregorio, BA Tuberville, TD Kennamer, RA Harris, BB Brisbin, IL AF DeGregorio, Brett A. Tuberville, Tracey D. Kennamer, Robert A. Harris, Bess B. Brisbin, I. Lehr, Jr. TI Spring emergence of Eastern Box Turtles (Terrapene carolina): influences of individual variation and scale of temperature correlates SO CANADIAN JOURNAL OF ZOOLOGY LA English DT Article DE emergence cues; Eastern Box Turtle; growing degree-days; dormancy ecology; individual variation; temperature; Terrapene carolina ID BLACK RAT SNAKES; HIBERNATION; PATTERNS; ENVIRONMENT; MORTALITY; JUVENILE; OBSOLETA; ECOLOGY; ORNATA; SIZE AB Many organisms spend considerable time in dormancy to avoid stressful environmental conditions. Understanding the timing and triggers of dormancy behavior is critical for understanding an animal's life history and behavior. Eastern Box Turtles (Terrapene carolina (L., 1758)) avoid winter temperatures by burrowing into the soil and remaining dormant. Identifying the proximate environmental cues that trigger emergence can improve conservation efforts by reducing potential aboveground turtle mortality. During a 17-year study, half of all variation in emergence timing was attributed to individual variation and the habitat that they occupied during dormancy. We suggest that individual variation in emergence timing is common within populations and confounds efforts to identify reliable emergence cues. Additionally, the scale of meteorological data limits the ability to identify emergence predictors. Using data from temperature loggers placed at dormancy locations, we found that surface air temperatures, averaged over the 5 days prior to emergence, were more strongly related to emergence probability than any variables derived from local weather stations. Turtles generally did not emerge from dormancy until the 5-day mean surface temperatures measured at dormancy sites reached approximately 15 degrees C. Our results suggest that individuals respond differently to environmental thresholds for emergence and individuals may be characterized as risk-taking or risk-aversive. C1 [DeGregorio, Brett A.; Tuberville, Tracey D.; Kennamer, Robert A.; Harris, Bess B.; Brisbin, I. Lehr, Jr.] Univ Georgia, Savannah River Ecol Lab, Aiken, SC 29802 USA. [Harris, Bess B.] Florida Fish & Wildlife Conservat Commiss, Fish & Wildlife Res Inst, Gainesville, FL 32653 USA. [DeGregorio, Brett A.] US Army Corps Engn, ERDC, CERL, Champaign, IL 61822 USA. RP DeGregorio, BA (reprint author), Univ Georgia, Savannah River Ecol Lab, Aiken, SC 29802 USA.; DeGregorio, BA (reprint author), US Army Corps Engn, ERDC, CERL, Champaign, IL 61822 USA. EM badegregorio@gmail.com FU U.S. Department of Energy [DE-FC09-07SR22506]; Outdoors Ministry Program of the Trinity Presbytery of the Presbyterian Church (USA) FX Throughout these studies, valuable fieldwork was provided by K. Cartee and B. Kirkland. We thank D. Scott for assistance summarizing data logger outputs and J. Waldron for her assistance in acquiring weather-station data. B. Kingsbury provided valuable guidance regarding Box Turtle overwintering ecology and the application of GDD. This research was supported by the U.S. Department of Energy under award DE-FC09-07SR22506 to the University of Georgia Research Foundation and by financial assistance provided by the Outdoors Ministry Program of the Trinity Presbytery of the Presbyterian Church (USA). NR 30 TC 0 Z9 0 U1 1 U2 1 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA SN 0008-4301 EI 1480-3283 J9 CAN J ZOOL JI Can. J. Zool. PD JAN PY 2017 VL 95 IS 1 BP 23 EP 30 DI 10.1139/cjz-2016-0149 PG 8 WC Zoology SC Zoology GA EK3BX UT WOS:000393802100004 ER PT J AU Chase, AM Clancy, HA Lachance, RP Mathison, BM Chiu, MM Weaver, GC AF Chase, A. M. Clancy, H. A. Lachance, R. P. Mathison, B. M. Chiu, M. M. Weaver, G. C. TI Improving critical thinking via authenticity: the CASPiE research experience in a military academy chemistry course SO CHEMISTRY EDUCATION RESEARCH AND PRACTICE LA English DT Article ID UNDERGRADUATE RESEARCH EXPERIENCES; STUDENTS; MUTATIONS; SCIENCE AB Course-based undergraduate research experiences (CUREs) can introduce many students to authentic research activities in a cost-effective manner. Past studies have shown that students who participated in CUREs report greater interest in chemistry, better data collection and analysis skills, and enhanced scientific reasoning compared to traditional laboratory activities. Though self-reports are informative, performance measures are needed to evaluate CURE effectiveness objectively. The present study examines whether a CURE implementation at the United States Military Academy (by the Center for Authentic Science Practice in Education [CASPiE]) affects students' self-reported perceptions or critical thinking test scores. Students reported significant increases in their perceptions of learning through the laboratory, authentic scientific laboratory practices and interest in chemistry when compared to previous chemistry courses with traditional laboratory activities. Results also showed a significant increase in critical thinking scores, moderated by student perception of the authenticity of the laboratory activities. C1 [Chase, A. M.; Chiu, M. M.] Purdue Univ, Dept Educ Studies, W Lafayette, IN 47907 USA. [Clancy, H. A.; Lachance, R. P.; Mathison, B. M.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Weaver, G. C.] Univ Massachusetts, Amherst, MA 01003 USA. RP Chase, AM (reprint author), Purdue Univ, Dept Educ Studies, W Lafayette, IN 47907 USA. EM tonychase@purdue.edu NR 35 TC 0 Z9 0 U1 0 U2 0 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1109-4028 J9 CHEM EDUC RES PRACT JI Chem. Educ. Res. Pract. PY 2017 VL 18 IS 1 BP 55 EP 63 DI 10.1039/c6rp00171h PG 9 WC Education & Educational Research; Education, Scientific Disciplines SC Education & Educational Research GA EK2MX UT WOS:000393762500005 ER PT J AU Waskiewicz, RJ Anders, MA Lenahan, PM Lelis, AJ AF Waskiewicz, Ryan J. Anders, Mark A. Lenahan, Patrick M. Lelis, Aivars J. TI Ionizing Radiation Effects in 4H-SiC nMOSFETs Studied With Electrically Detected Magnetic Resonance SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT 53rd IEEE Nuclear and Space Radiation Effects Conference (NSREC) CY JUL 11-15, 2016 CL Portland, OR SP IEEE, IEEE Nucl & Plasma Sci Soc, Radiat Effects Comm DE Electrically detected magnetic resonance; electron paramagnetic resonance; interface traps; MOSFET ID ELECTRON-SPIN-RESONANCE; SI/SIO2 INTERFACE; MOS DEVICES; SILICON; CENTERS; DEFECTS; HYDROGEN; MOSFETS; CHARGE; TRAPS AB Electrically detected magnetic resonance (EDMR) measurements of 4H-SiC/SiO2 metal-oxide-semiconductor field-effect transistors (MOSFETs) show large changes in the EDMR induced by gamma irradiation, indicating substantial changes in interface structure but, surprisingly, no generation of interface dangling bond defects. Our results indicate substantial fundamental atomic scale differences between radiation responses of Si/SiO2 based MOSFETs and SiC/SiO2 based MOSFETs. C1 [Waskiewicz, Ryan J.; Anders, Mark A.; Lenahan, Patrick M.] Penn State Univ, University Pk, PA 16802 USA. [Lelis, Aivars J.] US Army Res Lab, Adelphi, MD 20783 USA. RP Waskiewicz, RJ (reprint author), Penn State Univ, University Pk, PA 16802 USA. EM rjw5352@psu.edu; anders.mark@gmail.com; pmlesm@engr.psu.edu; aivars.j.lelis.civ@mail.mil FU U.S. Army Research Laboratory FX This work was supported by the U.S. Army Research Laboratory. NR 34 TC 0 Z9 0 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9499 EI 1558-1578 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD JAN PY 2017 VL 64 IS 1 BP 197 EP 203 DI 10.1109/TNS.2016.2622159 PN 1 PG 7 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA EO0RB UT WOS:000396404500029 ER PT J AU Pushpakaran, BN Bayne, SB Ogunniyi, AA AF Pushpakaran, Bejoy N. Bayne, Stephen B. Ogunniyi, Aderinto A. TI Electrothermal Simulation-Based Comparison of 4H-SiC p-i-n, Schottky, and JBS Diodes Under High Current Density Pulsed Operation SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE High current density; lattice heating; pulsed operation; silicon carbide (SiC); silvaco TCAD; thermal hot spot ID VOLTAGE; RECTIFIERS AB Pulsed power applications are characterized by very high instantaneous power due to the high voltage and current involved. Power diodes used as a closing switch in pulsed power circuits must be able to withstand the high current operation well above the continuous device rating, for a transient duration. Due to the superior electrothermal properties of wide bandgap Silicon Carbide (SiC) material, it is feasible to develop high Blocking Voltage (BV) Schottky and Junction Barrier Schottky (JBS) diodes besides p-i-n rectifiers. In order to evaluate the device performance under high current density pulsed operation, 2-D models of SiC p-i-n, Schottky, and JBS diodes rated for 3.3-kV BV and 100 A/cm(2) current density were developed using Silvaco ATLAS TCAD software. The diode structures were simulated electrothermally to study the device behavior and compare the performance under high current density pulsed operation. The power dissipation and the lattice temperature profile of the SiC diodes were analyzed to compare the magnitude of heat loss and formation of thermal hot spot in the diode structure to predict the suitability of the device for pulsed power applications. C1 [Pushpakaran, Bejoy N.; Bayne, Stephen B.] Texas Tech Univ, Ctr Pulsed Power & Power Elect, Lubbock, TX 79409 USA. [Ogunniyi, Aderinto A.] Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Pushpakaran, BN (reprint author), Texas Tech Univ, Ctr Pulsed Power & Power Elect, Lubbock, TX 79409 USA. EM bejoy.pushpakaran@ttu.edu; stephen.bayne@ttu.edu; aderinto.a.ogunniyi.civ@mail.mil OI Pushpakaran, Bejoy/0000-0002-1342-5951 FU Army Research Laboratory, Adelphi, MD, USA FX This work was supported by the Army Research Laboratory, Adelphi, MD, USA. NR 38 TC 0 Z9 0 U1 2 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 EI 1939-9375 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD JAN PY 2017 VL 45 IS 1 BP 68 EP 75 DI 10.1109/TPS.2016.2636214 PG 8 WC Physics, Fluids & Plasmas SC Physics GA EK2YX UT WOS:000393794100009 ER PT J AU Bartoszek, MW McCoart, A Hong, KSJ Haley, C Highland, KB Plunkett, AR AF Bartoszek, Michael W. McCoart, Amy Hong, Kyung-Soo Jason Haley, Chelsey Highland, Krista Beth Plunkett, Anthony R. TI An observational feasibility study to assess the safety and effectiveness of intranasal fentanyl for radiofrequency ablations of the lumbar facet joints SO JOURNAL OF PAIN RESEARCH LA English DT Article DE analgesia; spinal procedures; chronic pain; sedation ID RATING-SCALE DVPRS; MILITARY POPULATION; DOUBLE-BLIND; PAIN; TOLERABILITY; PHARMACOKINETICS; ANESTHESIA; SURGERY; DEFENSE; INJURY AB Purpose: The purpose of the present observational, feasibility study is to assess the preliminary safety and effectiveness of intranasal fentanyl for lumbar facet radiofrequency ablation procedures. Patients and methods: This cohort observational study included 23 adult patients. Systolic and diastolic blood pressures, heart rate, oxygen saturation percent, Pasero Opioid-Induced Sedation Scale score, and the Defense and Veterans Pain Rating Scale pain score were assessed prior to the procedure and intranasal fentanyl (100 mu g) administration and every 15 minutes after administration, up to 60 minutes post administration. Follow-up of patient satisfaction with pain control and treatment was assessed 24 hours after discharge. The primary outcome was safety as evidenced by adverse events. Secondary outcomes included the above-mentioned vital signs and pain ratings. Results: No adverse events occurred in the present study and all participants maintained an acceptable level of awareness throughout the assessment period. One-way repeated measures analyses of covariance tests with Bonferroni-adjusted means indicated that oxygen saturation, blood pressure, and heart rate changed from baseline, whereas pain scores were lower at post-administration levels compared with baseline. Finally, the majority of participants reported being satisfied with pain control and treatment. Conclusion: Preliminary evidence indicates that intranasal fentanyl is safe and effective for lumbar facet radiofrequency ablation procedures. Future rigorous randomized control trials are needed to confirm the present results and to examine the effects of intranasal fentanyl on intraoperative and postoperative opioid use. C1 [Bartoszek, Michael W.; Plunkett, Anthony R.] Womack Army Med Ctr, Dept Anesthesiol, Ft Bragg, NC USA. [McCoart, Amy; Haley, Chelsey] Womack Army Med Ctr, Henry M Jackson Fdn, Clin Invest Def & Vet Ctr Integrat Pain Managemen, Ft Bragg, NC USA. [Hong, Kyung-Soo Jason] Sceptor Pain Fdn, Clin Res Ctr, Res Dept, Winston Salem, NC USA. [Highland, Krista Beth] Uniformed Serv Univ Hlth Sci, Henry M Jackson Fdn, Def & Vet Ctr Integrat Pain Management, Bethesda, MD USA. RP McCoart, A (reprint author), Womack Army Med Ctr, Dept Clin Invest, 2817 Reilly Rd,Bldg 2517, Ft Bragg, NC 28310 USA. EM Amy.m.mccoart.ctr@mail.mil FU Depomed FX This study was made possible by the grant and study medication provided by Depomed. We would also like to thank the Pain Clinic staff at Womack for their assistance and support of this study. NR 22 TC 0 Z9 0 U1 0 U2 0 PU DOVE MEDICAL PRESS LTD PI ALBANY PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND SN 1178-7090 J9 J PAIN RES JI J. Pain Res. PY 2017 VL 10 BP 359 EP 364 DI 10.2147/JPR.S124180 PG 6 WC Clinical Neurology SC Neurosciences & Neurology GA EM2NY UT WOS:000395154000001 PM 28243139 ER PT J AU Torres, IP Torres, LN Valdez, C Salgado, C Cap, AP Dubick, MA AF Torres Filho, I. P. Torres, L. N. Valdez, C. Salgado, C. Cap, A. P. Dubick, M. A. TI Refrigerated platelets stored in whole blood up to 5 days adhere to thrombi formed during hemorrhagic hypotension in rats SO JOURNAL OF THROMBOSIS AND HAEMOSTASIS LA English DT Article DE hemorrhage; laser; microcirculation; muscle; platelet; shock; thrombus ID ACUTE TRAUMATIC COAGULOPATHY; FORMATION IN-VIVO; HEMOSTATIC EFFECTIVENESS; APHERESIS PLATELETS; MASSIVE TRANSFUSION; HEMATOCRIT; STORAGE; FLOW; RESUSCITATION; 4-DEGREES-C AB Background There is renewed interest in the therapeutic use of cold-stored platelets for bleeding patients. However, critical information is absent or partially available in vitro. Therefore, thrombus formation and platelet adhesion were studied in vivo, in situ, using bleeding and thrombosis models in instrumented rats, and confocal intravital videomicroscopy. Objectives We tested the hypothesis that refrigerated (4 degrees C) platelets (stored for 24 h or 5 days) participated in thrombus formation as well as platelets stored at room temperature (RT, 22 degrees C). This hypothesis was tested in normovolemia and hemorrhagic hypotension. Methods & Results After fluorescently-labeled platelet infusion, endothelial injury and vessel rupture were laser-induced in cremaster microvessels and platelet adhesion in > 230 developing thrombi was evaluated. Blood samples were collected for biochemistry and coagulation assays while multiple systemic physiologic parameters were recorded. Hemorrhagic hypotension study animals were subjected to 40% hemorrhage, leading to hypotension and hemodilution, during in vivo platelet adhesion assessments. The fluorescence intensity associated with labeled platelet adherence provided a quantitative index of adhesion. Cold-stored platelets performed as well as those stored at RT in normovolemic animals. During hypotension, cold-stored platelets still performed as well as RT-stored platelets, whereas platelet adhesion and thrombus formation were increased relative to normovolemic animals, in bleeding model experiments. Conclusions We found the methodology suitable for evaluating platelet function in vivo after different storage conditions in fully monitored animals. Refrigerated platelets (stored up to 5 days) participated as well as RT-stored platelets in thrombi formed after hemorrhage, suggesting that refrigerated platelets are effective during hypotensive situations. C1 [Torres Filho, I. P.; Torres, L. N.; Valdez, C.; Salgado, C.; Dubick, M. A.] US Army, Inst Surg Res, Damage Control Resuscitat, Ft Sam Houston, TX 78234 USA. [Cap, A. P.] US Army, Inst Surg Res, Coagulat & Blood Res Program, Ft Sam Houston, TX 78234 USA. RP Torres, IP (reprint author), US Army, Inst Surg Res, 3650 Chambers Pass,BHT-2,Room 282-1, Jbsa Ft Sam Houston, TX 78234 USA. EM ivo.p.torresfilho.civ@mail.mil FU US Army Medical Research Materiel Command FX The authors would like to thank R. Montgomery, G. Peeters, B. Furie, G. Merrill-Skoloff, M. D. Darlington, D. C. Zawieja, D. Prince and G. Muniz for their help during various phases of the study. This study was supported by the US Army Medical Research Materiel Command. It was performed in part while I. P. Torres Filho and L. N. Torres were employed by Premier Consulting & Management Services, Inc. and Cherokee Nation Businesses, respectively. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the US Department of the Army or the US Department of Defense. NR 53 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1538-7933 EI 1538-7836 J9 J THROMB HAEMOST JI J. Thromb. Haemost. PD JAN PY 2017 VL 15 IS 1 BP 163 EP 175 DI 10.1111/jth.13556 PG 13 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA EK5OI UT WOS:000393975300022 PM 27797452 ER PT J AU Legler, PM Compton, JR Hale, ML Anderson, GP Olson, MA Millard, CB Goldman, ER AF Legler, Patricia M. Compton, Jaimee R. Hale, Martha L. Anderson, George P. Olson, Mark A. Millard, Charles B. Goldman, Ellen R. TI Stability of isolated antibody-antigen complexes as a predictive tool for selecting toxin neutralizing antibodies SO MABS LA English DT Article DE Antibody complex; antibody selection; conformational change; mechanism of action; Tm-shift; toxins; unfolding ID STAPHYLOCOCCUS-AUREUS; MONOCLONAL-ANTIBODY; THERAPEUTICS; GENERATION; PROTEIN AB Ricin is an A-B ribosome inactivating protein (RIP) toxin composed of an A-chain subunit (RTA) that contains a catalytic N-glycosidase and a B-chain (RTB) lectin domain that binds cell surface glycans. Ricin exploits retrograde transport to enter into the Golgi and the endoplasmic reticulum, and then dislocates into the cytoplasm where it can reach its substrate, the rRNA. A subset of isolated antibodies (Abs) raised against the RTA subunit protect against ricin intoxication, and RTA-based vaccine immunogens have been shown to provide long-lasting protective immunity against the holotoxin. Anti-RTA Abs are unlikely to cross a membrane and reach the cytoplasm to inhibit the enzymatic activity of the A-chain. Moreover, there is not a strict correlation between the apparent binding affinity (K-a) of anti-RTA Abs and their ability to successfully neutralize ricin toxicity. Some anti-RTA antibodies are toxin-neutralizing, whereas others are not. We hypothesize that neutralizing anti-RTA Abs may interfere selectively with conformational change (s) or partial unfolding required for toxin internalization. To test this hypothesis, we measured the melting temperatures (T-m) of neutralizing single-domain Ab (sdAb)-antigen (Ag) complexes relative to the T-m of the free antigen (T-m-shift = T-m(complex) - T-m(Ag)), and observed increases in the T-m(complex) of 9-20 degrees. In contrast, non-neutralizing sdAb-Ag complexes shifted the T-m(Complex) by only 6-7 degrees. A strong linear correlation (r(2) = 0.992) was observed between the magnitude of the T-m-shift and the viability of living cells treated with the sdAb and ricin holotoxin. The T-m-shift of the sdAb-Ag complex provided a quantitative biophysical parameter that could be used to predict and rank-order the toxin-neutralizing activities of Abs. We determined the first structure of an sdAb-RTA1-33/44-198 complex, and examined other sdAb-RTA complexes. We found that neutralizing sdAb bound to regions involved in the early stages of unfolding. These Abs likely interfere with steps preceding or following endocytosis that require conformational changes. This method may have utility for the characterization or rapid screening of other Ab that act to prevent conformational changes or unfolding as part of their mechanism of action. C1 [Legler, Patricia M.; Anderson, George P.; Goldman, Ellen R.] US Naval Res Lab, Washington, DC USA. [Compton, Jaimee R.] NOVA Res Inc, Alexandria, VA USA. [Hale, Martha L.; Olson, Mark A.; Millard, Charles B.] US Army Med Res Inst Infect Dis, Frederick, MD USA. RP Legler, PM (reprint author), Naval Res Lab, 4555 Overlook Ave, Washington, DC 20375 USA. EM patricia.legler@nrl.navy.mil FU Defense Threat Reduction Agency (DTRA) [CBCALL12-LS6-2-0036]; Office of Naval Research (ONR) [6.1] FX This work was funded by the Defense Threat Reduction Agency (DTRA) project number CBCALL12-LS6-2-0036 and the Office of Naval Research (ONR) 6.1 base funding. The opinions expressed here are those of the authors and do not represent those of the United States Department of Defense or any other agency of the United States government. NR 22 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1942-0862 EI 1942-0870 J9 MABS-AUSTIN JI mAbs PY 2017 VL 9 IS 1 BP 43 EP 57 DI 10.1080/19420862.2016.1236882 PG 15 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA EK2TG UT WOS:000393779000004 PM 27660893 ER PT J AU Dyson, ZA Thanh, DP Bodhidatta, L Mason, CJ Srijan, A Rabaa, MA Vinh, PV Thanh, TH Thwaites, GE Baker, S Holt, KE AF Dyson, Zoe A. Duy Pham Thanh Bodhidatta, Ladaporn Mason, Carl Jeffries Srijan, Apichai Rabaa, Maia A. Phat Voong Vinh Tuyen Ha Thanh Thwaites, Guy E. Baker, Stephen Holt, Kathryn E. TI Whole Genome Sequence Analysis of Salmonella Typhi Isolated in Thailand before and after the Introduction of a National Immunization Program SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID ENTERICA SEROVAR TYPHI; FEVER; PLASMIDS; VACCINES; BACTERIOPHAGE; BURDEN; PHAGE; ASIA; COEVOLUTION; VACCINATION AB Vaccines against Salmonella Typhi, the causative agent of typhoid fever, are commonly used by travellers, however, there are few examples of national immunization programs in endemic areas. There is therefore a paucity of data on the impact of typhoid immunization programs on localised populations of S. Typhi. Here we have used whole genome sequencing ( WGS) to characterise 44 historical bacterial isolates collected before and after a national typhoid immunization program that was implemented in Thailand in 1977 in response to a large outbreak; the program was highly effective in reducing typhoid case numbers. Thai isolates were highly diverse, including 10 distinct phylogenetic lineages or genotypes. Novel prophage and plasmids were also detected, including examples that were previously only reported in Shigella sonnei and Escherichia coli. The majority of S. Typhi genotypes observed prior to the immunization program were not observed following it. Postvaccine era isolates were more closely related to S. Typhi isolated from neighbouring countries than to earlier Thai isolates, providing no evidence for the local persistence of endemic S. Typhi following the national immunization program. Rather, later cases of typhoid appeared to be caused by the occasional importation of common genotypes from neighbouring Vietnam, Laos, and Cambodia. These data show the value of WGS in understanding the impacts of vaccination on pathogen populations and provide support for the proposal that large-scale typhoid immunization programs in endemic areas could result in lasting local disease elimination, although larger prospective studies are needed to test this directly. C1 [Dyson, Zoe A.; Holt, Kathryn E.] Univ Melbourne, Ctr Syst Genom, Parkville, Vic, Australia. [Dyson, Zoe A.; Holt, Kathryn E.] Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic, Australia. [Duy Pham Thanh; Rabaa, Maia A.; Phat Voong Vinh; Tuyen Ha Thanh; Thwaites, Guy E.; Baker, Stephen] Univ Oxford, Clin Res Unit, Hosp Trop Dis, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam. [Bodhidatta, Ladaporn; Mason, Carl Jeffries; Srijan, Apichai] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok, Thailand. [Rabaa, Maia A.; Thwaites, Guy E.; Baker, Stephen] Univ Oxford, Ctr Trop Med & Global Hlth, Oxford, England. [Baker, Stephen] London Sch Hyg & Trop Med, London, England. RP Dyson, ZA; Holt, KE (reprint author), Univ Melbourne, Ctr Syst Genom, Parkville, Vic, Australia.; Dyson, ZA; Holt, KE (reprint author), Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic, Australia. EM zoe.dyson@unimelb.edu.au; kholt@unimelb.edu.au FU Wellcome Trust of Great Britain [106158/Z/14/Z]; Wellcome Trust [100087/Z/12/Z]; Royal Society [100087/Z/12/Z]; ZAD [106158]; NHMRC of Australia [1061409]; Oak Foundation FX This project was funded by the Wellcome Trust of Great Britain (106158/Z/14/Z); SB is a Sir Henry Dale Fellow, jointly funded by the Wellcome Trust and the Royal Society (100087/Z/12/Z) and ZAD is funded by strategic award #106158. KEH is supported by fellowship #1061409 from the NHMRC of Australia. DTP is a leadership fellow funded through the Oak Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The view expressed in this article are those of the author(s) and do not reflect the official policy of the Department of the Army, Department of Defense, or the US government. NR 68 TC 0 Z9 0 U1 1 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2017 VL 11 IS 1 AR e0005274 DI 10.1371/journal.pntd.0005274 PG 15 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA EK8CR UT WOS:000394152000046 ER PT J AU Smith, DR Hollidge, B Daye, S Zeng, XK Blancett, C Kuszpit, K Bocan, T Koehler, JW Coyne, S Minogue, T Kenny, T Chi, XL Yim, S Miller, L Schmaljohn, C Bavari, S Golden, JW AF Smith, Darci R. Hollidge, Bradley Daye, Sharon Zeng, Xiankun Blancett, Candace Kuszpit, Kyle Bocan, Thomas Koehler, Jeff W. Coyne, Susan Minogue, Tim Kenny, Tara Chi, Xiaoli Yim, Soojin Miller, Lynn Schmaljohn, Connie Bavari, Sina Golden, Joseph W. TI Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID INFECTION; TRANSMISSION; MICE; BRAZIL; ISOLATIONS; PROTECTION; PREGNANCY; OUTBREAK; DENGUE; STATES AB Animal models are needed to better understand the pathogenic mechanisms of Zika virus (ZIKV) and to evaluate candidate medical countermeasures. Adult mice infected with ZIKV develop a transient viremia, but do not demonstrate signs of morbidity or mortality. Mice deficient in type I or a combination of type I and type II interferon (IFN) responses are highly susceptible to ZIKV infection; however, the absence of a competent immune system limits their usefulness for studying medical countermeasures. Here we employ a murine model for ZIKV using wild-type C57BL/6 mice treated with an antibody to disrupt type I IFN signaling to study ZIKV pathogenesis. We observed 40% mortality in antibody treated mice exposed to ZIKV subcutaneously whereas mice exposed by intraperitoneal inoculation were highly susceptible incurring 100% mortality. Mice infected by both exposure routes experienced weight loss, high viremia, and severe neuropathologic changes. The most significant histopathological findings occurred in the central nervous system where lesions represent an acute to subacute encephalitis/encephalomyelitis that is characterized by neuronal death, astrogliosis, microgliosis, scattered necrotic cellular debris, and inflammatory cell infiltrates. This model of ZIKV pathogenesis will be valuable for evaluating medical countermeasures and the pathogenic mechanisms of ZIKV because it allows immune responses to be elicited in immunologically competent mice with IFN I blockade only induced at the time of infection. C1 [Smith, Darci R.; Hollidge, Bradley; Golden, Joseph W.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Daye, Sharon; Zeng, Xiankun; Blancett, Candace; Yim, Soojin] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. [Kuszpit, Kyle; Bocan, Thomas; Kenny, Tara; Chi, Xiaoli] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA. [Koehler, Jeff W.; Coyne, Susan; Minogue, Tim] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Miller, Lynn] US Army, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA. [Schmaljohn, Connie; Bavari, Sina] US Army, Med Res Inst Infect Dis, Headquarters Div, Ft Detrick, MD 21702 USA. RP Smith, DR (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM darci.r.smith.ctr@mail.mil; joseph.w.golden.ctr@mail.mil FU DARPA FX This work was supported by DARPA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 60 TC 0 Z9 0 U1 2 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2017 VL 11 IS 1 AR e0005296 DI 10.1371/journal.pntd.0005296 PG 22 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA EK8CR UT WOS:000394152000063 ER PT J AU Yadava, A Waters, NC AF Yadava, Anjali Waters, Norman C. TI Rationale for Further Development of a Vaccine Based on the Circumsporozoite Protein of Plasmodium vivax SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID MALARIA VACCINE; IMMUNOGENICITY; ANTIBODIES; RESPONSES; EFFICACY C1 [Yadava, Anjali; Waters, Norman C.] Walter Reed Army Inst Res, US Mil Malaria Res Program, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. RP Yadava, A (reprint author), Walter Reed Army Inst Res, US Mil Malaria Res Program, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. EM Anjali.Yadava.Civ@mail.mil NR 14 TC 0 Z9 0 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2017 VL 11 IS 1 AR e0005164 DI 10.1371/journal.pntd.0005164 PG 5 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA EK8CR UT WOS:000394152000012 ER PT J AU Howarth, AJ Buru, CT Liu, YY Ploskonka, AM Hartlieb, KJ McEntee, M Mahle, JJ Buchanan, JH Durke, EM Al-Juaid, SS Stoddart, JF DeCoste, JB Hupp, JT Farha, OK AF Howarth, Ashlee J. Buru, Cassandra T. Liu, Yangyang Ploskonka, Ann M. Hartlieb, Karel J. McEntee, Monica Mahle, John J. Buchanan, James H. Durke, Erin M. Al-Juaid, Salih S. Stoddart, J. Fraser DeCoste, Jared B. Hupp, Joseph T. Farha, Omar K. TI Postsynthetic Incorporation of a Singlet Oxygen Photosensitizer in a Metal-Organic Framework for Fast and Selective Oxidative Detoxification of Sulfur Mustard SO CHEMISTRY-A EUROPEAN JOURNAL LA English DT Article DE fullerene; metal-organic frameworks; pyrene; singlet oxygen; sulfur mustard ID CHEMICAL WARFARE AGENTS; ASSISTED LIGAND INCORPORATION; HD ANALOGS; STABILITY; PLATFORM; DESIGN; WATER; GAS; FUNCTIONALIZATION; DECONTAMINATION AB A fullerene-based photosensitizer is incorporated postsynthetically into a Zr-6 -based MOF, NU-1000, for enhanced singlet oxygen production. The structural organic linkers in the MOF platform also act as photosensitizers which contribute to the overall generation of singlet oxygen from the material under UV irradiation. The singlet oxygen generated by the MOF/fullerene material is shown to oxidize sulfur mustard selectively to the less toxic bis(2-chloroethyl)sulfoxide with a half-life of only 11 min. C1 [Howarth, Ashlee J.; Buru, Cassandra T.; Liu, Yangyang; Hartlieb, Karel J.; Stoddart, J. Fraser; Hupp, Joseph T.; Farha, Omar K.] Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA. [Ploskonka, Ann M.] Leidos Inc, Edgewood Chem Biol Ctr, POB 68, Aberdeen Proving Ground, MD 21010 USA. [McEntee, Monica; Mahle, John J.; Buchanan, James H.; Durke, Erin M.; DeCoste, Jared B.] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. [Al-Juaid, Salih S.; Farha, Omar K.] King Abdulaziz Univ, Dept Chem, Fac Sci, Jeddah, Saudi Arabia. RP Farha, OK (reprint author), Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA.; Farha, OK (reprint author), King Abdulaziz Univ, Dept Chem, Fac Sci, Jeddah, Saudi Arabia. EM o-farha@northwestern.edu FU Army Research Office [W911NF-13-1-0229]; Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) [BA13PHM210]; Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah [23-130-36-HiCi]; NSERC FX The authors gratefully acknowledge support from the Army Research Office (project no. W911NF-13-1-0229) for the synthesis and characterization of all MOF-based materials and CEES oxidation studies. J.B.D. acknowledges the Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) for funding under BA13PHM210 for all HD oxidation studies. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the ECBC for M.M. administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ECBC. J.F.S. and K.J.H. thank the Joint Center of Excellence in Integrated Nano-Systems (JCIN) at King Abdulaziz City of Science and Technology (KACST) and Northwestern University (NU) for their support in the synthesis of PCBA. O.K.F. and S.S.A. contributions to this project were funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, under grant no. 23-130-36-HiCi. A.J.H. thanks NSERC for a postdoctoral fellowship. NR 62 TC 0 Z9 0 U1 7 U2 7 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0947-6539 EI 1521-3765 J9 CHEM-EUR J JI Chem.-Eur. J. PD JAN 1 PY 2017 VL 23 IS 1 BP 214 EP 218 DI 10.1002/chem.201604972 PG 5 WC Chemistry, Multidisciplinary SC Chemistry GA EK0EO UT WOS:000393599700032 PM 27780293 ER PT J AU Harms, NE Shearer, JF Grodowitz, MJ AF Harms, Nathan E. Shearer, Judy F. Grodowitz, Michael J. TI Folivory and disease occurrence on Ludwigia hexapetala in Guntersville Reservoir, Alabama SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE aquatic weed; biological control; invasive species; natural enemies; new associations; plant pathogens ID UNITED-STATES; BIOLOGICAL-CONTROL; RUMEX-CRISPUS; PLANTS; HERBIVORES; ONAGRACEAE; INSECTS; INFECTION; FUNGUS AB We report leaf feeding, disease occurrence, and associated indigenous herbivore/fungal pathogen communities on the introduced wetland species Ludwigia hexapetala at Guntersville Reservoir, AL. Plant populations were sampled on three dates from May to September 2014. A complex of indigenous herbivore and fungal taxa, mostly known from other Ludwigia spp., resulted in peak feeding and disease occurrence on 88% and 92% of sampled leaves, respectively. Herbivore damage declined over the growing season from 78 to 21% of sampled leaves, and disease symptom occurrence increased from 0 to 80%. Total leaf damage (percent leaf area) from both herbivory and disease was determined by software image analyses of floating and aerial leaves and reached 14% total reduction in photosynthetic tissues by September 2014. Aerial leaves were more commonly affected by disease symptoms, whereas floating leaves had a greater incidence of herbivore damage. Fourteen insect herbivore and seven fungal taxa were associated with L. hexapetala at Guntersville Reservoir. Despite the diverse assemblage of herbivores and fungi associated with L. hexapetala, damage was relatively low and the weed continues to persist as a nuisance species at this and other sites in southeastern United States. However, these results along with past surveys and literature review demonstrate the ability of common Ludwigia arthropod herbivores in the United States to host shift between Ludwigia spp. This begs the question as to how difficult it will be to locate potential biocontrol agents of L. hexapetala outside the United States that will be sufficiently host specific to present little to no risk to native Ludwigia spp. C1 [Harms, Nathan E.; Shearer, Judy F.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Grodowitz, Michael J.] USDA ARS, Stoneville, MS 38776 USA. RP Harms, NE (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Nathan.E.Harms@usace.army.mil NR 45 TC 0 Z9 0 U1 0 U2 0 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2017 VL 55 BP 19 EP 25 PG 7 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA EK1XN UT WOS:000393721200003 ER PT J AU Williams, DA Harms, NE Dodd, L Grodowitz, MJ Dick, GO AF Williams, Dean A. Harms, Nathan E. Dodd, Lynde Grodowitz, Michael J. Dick, Gary O. TI Do the US dioecious and monoecious biotypes of Hydrilla verticillata hybridize? SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID EURASIAN WATERMILFOIL; ORGANISMS; EVOLUTION; ECOLOGY; PLANTS C1 [Williams, Dean A.] Texas Christian Univ, Dept Biol, Ft Worth, TX 76129 USA. [Harms, Nathan E.; Grodowitz, Michael J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Dodd, Lynde; Dick, Gary O.] US Army Engineer Lewisville Aquat Ecosyst Res Fac, Lewisville, TX 75057 USA. RP Williams, DA (reprint author), Texas Christian Univ, Dept Biol, Ft Worth, TX 76129 USA. EM dean.williams@tcu.edu FU U.S. Army Corps of Engineers Aquatic Plant Control Research Program FX We would like to thank Linda Nelson, Judy Shearer, Ryan Thum, and two reviewers for their comments on earlier drafts of this manuscript. Funding for this work was provided by the U.S. Army Corps of Engineers Aquatic Plant Control Research Program. NR 23 TC 0 Z9 0 U1 0 U2 0 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2017 VL 55 BP 35 EP 38 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA EK1XN UT WOS:000393721200005 ER PT J AU Netherland, MD Willey, L AF Netherland, Michael D. Willey, Leif TI Mesocosm evaluation of three herbicides on Eurasian watermilfoil (Myriophyllum spicatum) and hybrid watermilfoil (Myriophyllum spicatum x Myriophyllum sibiricum): Developing a predictive assay SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID FLURIDONE; TRICLOPYR; MILFOILS; 2,4-D C1 [Netherland, Michael D.] US Army Engineer Res & Dev Ctr, 7922 NW 71st St, Gainesville, FL 32653 USA. [Willey, Leif] SePRO Corp, 11550 North Meridian St,Suite 600, Carmel, IN 46032 USA. RP Netherland, MD (reprint author), US Army Engineer Res & Dev Ctr, 7922 NW 71st St, Gainesville, FL 32653 USA. EM Michael.D.Netherland@usace.ariny.mil FU U.S. Army Engineer Research and Development Center, Aquatic Plant Control Research Program; Minnesota Department of Natural Resources, Invasive Species Program, Division of Ecological and Water Resources FX Funding for this project was provided by the U.S. Army Engineer Research and Development Center, Aquatic Plant Control Research Program, and via a Cooperative Research and Development Agreement by the Minnesota Department of Natural Resources, Invasive Species Program, Division of Ecological and Water Resources. Citation of trade names does not constitute endorsement or approval of the use of such commercial products. Permission to publish this article was granted by the Chief of Engineers. NR 15 TC 0 Z9 0 U1 1 U2 1 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2017 VL 55 BP 39 EP 41 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA EK1XN UT WOS:000393721200006 ER PT J AU Patusco, R Smith, TJ Ziegler, J AF Patusco, Rachael Smith, Tracey J. Ziegler, Jane TI The Role of Fructose, and Specifically Sugar-Sweetened Beverages, in Pediatric Nonalcoholic Fatty Liver Disease SO TOPICS IN CLINICAL NUTRITION LA English DT Article DE fructose; hepatic steatosis; nonalcoholic fatty liver; sugar-sweetened beverage ID HISPANIC-AMERICAN ADOLESCENTS; VISCERAL ADIPOSITY; INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC STEATOSIS; OBESE ADOLESCENTS; GENETIC-VARIATION; DIETARY FRUCTOSE; RISK-FACTORS; CORN SYRUP AB The prevalence of nonalcoholic fatty liver disease (NAFLD) among US children and adolescents is rising, with diet identified as a risk factor. The clinical burden of pediatric NAFLD makes it a serious health concern. The aim of this review was to explore the association between fructose consumption, specifically sugar-sweetened beverage intake, and NAFLD and the effect of fructose on associated risk factors. The relationship that fructose may have with NAFLD and its related risk factors may highlight whether certain dietary constituents should be altered among those with NAFLD. C1 [Patusco, Rachael; Ziegler, Jane] Rutgers State Univ, Sch Hlth Profess, Grad Programs Clin Nutr, Newark, NJ 07107 USA. [Smith, Tracey J.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA USA. RP Patusco, R (reprint author), Rutgers State Univ, Sch Hlth Profess, Grad Programs Clin Nutr, Newark, NJ 07107 USA. EM brauerra@shp.rutgers.edu NR 50 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0883-5691 EI 1550-5146 J9 TOP CLIN NUTR JI Top. Clin. Nutr. PD JAN-MAR PY 2017 VL 32 IS 1 BP 27 EP 46 DI 10.1097/TIN.0000000000000091 PG 20 WC Nutrition & Dietetics SC Nutrition & Dietetics GA EK2MY UT WOS:000393762600004 ER PT J AU Buxton, VL Sperry, JH AF Buxton, Valerie L. Sperry, Jinelle H. TI Reproductive Decisions in Anurans: A Review of How Predation and Competition Affects the Deposition of Eggs And Tadpoles SO BIOSCIENCE LA English DT Article DE anuran; offspring deposition; breeding-habitat selection; predation; competition ID OVIPOSITION-SITE SELECTION; PERUVIAN POISON FROGS; HABITAT SELECTION; BREEDING HABITAT; CHEMICAL CUES; WOOD FROGS; CONSPECIFIC-ATTRACTION; PARENTAL DECISIONS; PUBLIC INFORMATION; NEOTROPICAL FROG AB The selection of breeding habitat has broadscale implications for species distributions and community structure and smaller-scale ramifications for offspring survival and parental fitness. In anurans, offspring deposition is a decisionmaking process that involves the assessment of multiple factors at a breeding site, including the presence of predators and competitors. Evolutionary theory predicts that adult anurans should seek to minimize the risk of predation to offspring, reduce the pressure of competition, and maximize offspring survival. Many experimental studies have demonstrated the ability of anurans to assess deposition sites for predation and competition and to choose accordingly, but our understanding of the various ecological factors involved in site choice and the broader consequences of choice is still limited. Here, we review and synthesize the literature on the influence of predators and competitors on anuran deposition behavior. We highlight current gaps in our understanding of this topic and outline future avenues of research. C1 [Buxton, Valerie L.; Sperry, Jinelle H.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL USA. RP Buxton, VL (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. EM vbuxton2@illinois.edu FU Construction Engineering Research Laboratory of the Engineer Research Development Center FX We thank Brett DeGregorio and Daniel Kovar for providing feedback on this manuscript. Special thanks to the three anonymous reviewers for their comments and critiques of this manuscript. Funding was provided by the Construction Engineering Research Laboratory of the Engineer Research Development Center. NR 85 TC 0 Z9 0 U1 4 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0006-3568 EI 1525-3244 J9 BIOSCIENCE JI Bioscience PD JAN PY 2017 VL 67 IS 1 BP 25 EP 37 DI 10.1093/biosci/biw149 PG 13 WC Biology SC Life Sciences & Biomedicine - Other Topics GA EL0VH UT WOS:000394339400005 ER PT J AU Brusnahan, JS Shaw, AP Moretti, JD Eck, WS AF Brusnahan, Jason S. Shaw, Anthony P. Moretti, Jared D. Eck, William S. TI Periodates as Potential Replacements for Perchlorates in Pyrotechnic Compositions SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Perchlorates; Periodates; Flash; Incendiary; Sustainable pyrotechnics ID GREEN-LIGHT ILLUMINANTS; HAND-HELD SIGNAL; DELAY; METAPERIODATE; DECOMPOSITION; PERFORMANCE; KINETICS; SALTS AB The periodate salts NaIO4 and KIO4 are critically evaluated as potential replacements for KClO4 in pyrotechnic compositions. Key differences between the physical and chemical properties of the periodate and perchlorate oxidizers are presented. The thermochemical characteristics of binary flash/incendiary compositions containing Al, MgAl, or Mg as the fuel and periodate or perchlorate salts as oxidizers were studied using the FactSage 6.4 software package. The computational results are compared to existing experimental data. The tendency of NaIO4 to form gaseous Na, an emitter of yellow light, in such reactions promotes high luminous efficiencies. Due to a lack of literature addressing the stability and aging characteristics of periodate-containing formulations, it is recommended that further research should be undertaken to evaluate potential chemical incompatibilities. Other concerns, including the availability and toxicological properties of the periodates, are also discussed. C1 [Brusnahan, Jason S.] Def Sci & Technol Grp, Edinburgh, SA 5111, Australia. [Shaw, Anthony P.; Moretti, Jared D.] US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. [Eck, William S.] US Army MEDCOM APHC, Army Publ Hlth Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Shaw, AP (reprint author), US Army RDECOM ARDEC, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. EM anthony.p.shaw.civ@mail.mil FU U.S. Army; Defence Science and Technology Group FX The U.S. Army is thanked for funding this work. Jason S. Brusnahan thanks the Defence Science and Technology Group for funding his International Fellowship at Picatinny Arsenal, NJ, USA. Jay C. Poret is thanked for acquiring the FactSage software package. NR 46 TC 0 Z9 0 U1 0 U2 0 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 0721-3115 EI 1521-4087 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD JAN PY 2017 VL 42 IS 1 BP 62 EP 70 DI 10.1002/prep.201600084 PG 9 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA EJ6II UT WOS:000393322300007 ER PT J AU Smith, JM AF Smith, Jane Mckee TI Resilience Through Research: Innovations for Tackling Coastal Risk SO SEA TECHNOLOGY LA English DT Editorial Material C1 [Smith, Jane Mckee] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Smith, JM (reprint author), US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COMPASS PUBLICATIONS, INC PI ARLINGTON PA 1501 WILSON BLVD., STE 1001, ARLINGTON, VA 22209-2403 USA SN 0093-3651 J9 SEA TECHNOL JI Sea Technol. PD JAN PY 2017 VL 58 IS 1 BP 19 EP 20 PG 2 WC Engineering, Ocean SC Engineering GA EJ3ZK UT WOS:000393151600006 ER PT J AU Sahu, J AF Sahu, Jubaraj TI CFD Simulations of a Finned Projectile with Microflaps for Flow Control SO INTERNATIONAL JOURNAL OF AEROSPACE ENGINEERING LA English DT Article ID SUPERSONIC JET INTERACTION; MISSILE; ACTUATORS; SPEEDS; BODIES; SYSTEM AB This research describes a computational study undertaken to determine the effect of a flow control mechanism and its associated aerodynamics for a finned projectile. The flow control system consists of small microflaps located between the rear fins of the projectile. These small microflaps alter the flow field in the aft finned region of the projectile, create asymmetric pressure distributions, and thus produce aerodynamic control forces and moments. A number of different geometric parameters, microflap locations, and the number of microflaps were varied in an attempt to maximize the control authority generated by the flaps. Steady-state Navier-Stokes computations were performed to obtain the control aerodynamic forces and moments associated with the microflaps. These results were used to optimize the control authority at a supersonic speed, M = 2.5. Computed results showed not only the microflaps to be effective at this speed, but also configurations with 6 and 8 microflaps were found to generate 25%-50% more control force than a baseline 4-flap configuration. These results led to a new optimized 8-flap configuration that was further investigated for a range of Mach numbers from M = 0.8 to 5.0 and was found to be a viable configuration effective in providing control at all of these speeds. C1 [Sahu, Jubaraj] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sahu, J (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jubaraj.sahu.civ@mail.mil FU Georgia Institute of Technology FX The author would like to thank the US Department of Defense (DoD) High-Performance Computing Modernization program and the DoD Supercomputing Resource Centers for providing critically needed high-performance computer resources for the successful accomplishment of this work. The author also wishes to thank Metacomp Technologies personnel for their help with the mesh generation and the use of their unstructured meshing software and Jonathan Rogers, Georgia Institute of Technology, for providing partial funding of this work. NR 61 TC 0 Z9 0 U1 0 U2 0 PU HINDAWI LTD PI LONDON PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND SN 1687-5966 EI 1687-5974 J9 INT J AEROSPACE ENG JI Int. J. Aerosp. Eng. PY 2017 AR 4012731 DI 10.1155/2017/4012731 PG 15 WC Engineering, Aerospace SC Engineering GA EJ6HI UT WOS:000393319600001 ER PT J AU Alighalehbabakhani, F Miller, CJ Selegean, JP Barkach, J Abkenar, SMS Dahl, T Baskaran, M AF Alighalehbabakhani, Fatemeh Miller, Carol J. Selegean, James P. Barkach, John Abkenar, Seyed Mohsen Sadatiyan Dahl, Travis Baskaran, Mark TI Estimates of sediment trapping rates for two reservoirs in the Lake Erie watershed: Past and present scenarios SO JOURNAL OF HYDROLOGY LA English DT Article DE Sediment accumulation rate; Dams; Reservoir; Watershed; Lake Erie; SWAT model ID LAND-USE; SOUTHERN PORTUGAL; FLUVIAL-SEDIMENT; COASTAL OCEAN; RIVER; SWAT; REMOVAL; IMPACTS; CLIMATE; CHANNEL AB Sediment accumulation can significantly impact the useful life of dams and the multiple functions served by those dams such as flood attenuation, hydropower, and water supply. However, there is only limited information, and even fewer physical measurements, assessing the rate of sediment accumulation in reservoirs behind dams. Many of the dams within the Great Lakes Watershed were constructed between 100 and 120 years ago, and there is reasonable concern that these dams and their associated reservoirs may be reaching capacity with respect to sediment storage. As a reservoir reaches its sediment storage capacity, there are numerous risks. Excess sediment can compromise the water intake for supply systems. Dam failure or removal can potentially allow large quantities of impounded sediment to migrate downstream, negatively impacting fish habitat and water quality. This research investigates the historical function of dams as sediment storage points. Also, this research assesses the effect of anthropogenic influences including land use change and dam construction on sediment yield and accumulation within the Lake Rockwell and Ballville Dam watershed. To better understand the historical and current sediment yield within the Lake Erie watershed, Soil and Water Assessment Tool (SWAT) models of the Lake Rockwell and Ballville Dam watersheds were developed. The resulting model suggests that the average of sediment accumulation rate within Lake Rockwell Dam reservoir varies between the minimum of 1.6 and the maximum of 4.6 g/cm(2)/yr from 1988 to 2007. Within the Ballville Dam reservoir, the rate varies between the minimum of 2.6 and the maximum of 23.2 g/cm(2)/yr from 1980 to 1999. (C) 2016 Elsevier B.V. All rights reserved. C1 [Alighalehbabakhani, Fatemeh; Miller, Carol J.; Barkach, John; Abkenar, Seyed Mohsen Sadatiyan] Wayne State Univ, Dept Civil & Environm Engn, Detroit, MI 48202 USA. [Baskaran, Mark] Wayne State Univ, Dept Geol, Detroit, MI 48202 USA. [Selegean, James P.] US Army Corps Engineers, Detroit, MI USA. RP Alighalehbabakhani, F (reprint author), Wayne State Univ, Dept Civil & Environm Engn, Detroit, MI 48202 USA. EM babakhani.fatemeh@gmail.com FU Detroit District, US Army Corps of Engineers [W911XK-14-C-0023] FX I would like to thank the Detroit District, US Army Corps of Engineers for funding this research. The contract number of this project is No. W911XK-14-C-0023. NR 39 TC 0 Z9 0 U1 8 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 EI 1879-2707 J9 J HYDROL JI J. Hydrol. PD JAN PY 2017 VL 544 BP 147 EP 155 DI 10.1016/j.jhydrol.2016.11.032 PG 9 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA EI8OR UT WOS:000392767000013 ER PT J AU Boyd, BM Sommerfield, CK Elsey-Quirk, T AF Boyd, B. M. Sommerfield, C. K. Elsey-Quirk, T. TI Hydrogeomorphic influences on salt marsh sediment accumulation and accretion in two estuaries of the US Mid-Atlantic coast SO MARINE GEOLOGY LA English DT Article DE Salt marsh; Lagoon estuary; Coastal plain estuary; Radionuclide geochronology ID SEA-LEVEL CHANGE; SPARTINA-ALTERNIFLORA LOISEL; TIDAL FRESH-WATER; DELAWARE ESTUARY; NEW-JERSEY; RATES; GROWTH; BAY; LOUISIANA; WETLANDS AB Salt marshes in two contrasting estuaries of the U.S. Mid-Atlantic coast, Barnegat Bay and Delaware Bay, were investigated to identify relationships between rates of sedimentation and marsh estuarine geomorphic setting. Barnegat Bay is a microtidal lagoon estuary with back-barrier and mainland coastal marshes, whereas Delaware Bay is a micro-mesotidal coastal plain estuary with sediment-rich estuarine marshes. Salt marshes of both estuaries are dominated by Spartina alterrallora. An analysis was performed to characterize marsh hypsometry and tidal flooding characteristics, and a coring study was conducted to measure rates of mineral sediment accumulation, organic matter accumulation, and vertical accretion using Cs-137 and Pb-210 chronology at nine sites in both estuaries. Mineral sediment and organic matter accumulation rates were significantly higher in Delaware Bay marshes (sediment mean and 1 sigma. 2.57 +/- 2.03 kg m(-2) year(-1); organic: 0.65 +/- 0.26 kg m(-2) year(-1)) than in Barnegat Bay (sediment: 0.31 +/- 0.27 kg m(-2) year(-1); organic: 0.29 +/- 0.08 kg m(-2) year(-1)), as were rates of accretion (Delaware Bay: 0.79 +/- 0.06 cm year(-1); Barnegat Bay: 0.28 +/- 0.06 cm year(-1)). Regression analysis indicated that marsh accretion rates were positively correlated with rates of sediment and organic accumulation, but the upper limit of accretion was governed by sediment accumulation. Tidal flooding frequency and duration did not correlate with marsh accumulation or accretion rates in either estuary, suggesting that hydroperiod is subordinate to sediment availability in governing rates on 50-100 year time scales. If true, natural and (or) human influences on suspended-sediment production and transport in these estuaries has potential to impact marsh accretionary status and stability, independent of sea-level rise. (C) 2016 Elsevier B.V. All rights reserved. C1 [Boyd, B. M.; Sommerfield, C. K.] Univ Delaware, Sch Marine Sci & Policy, Lewes, DE 19958 USA. [Boyd, B. M.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Elsey-Quirk, T.] Louisiana State Univ, Dept Oceanog & Coastal Sci, Baton Rouge, LA 70803 USA. RP Boyd, BM (reprint author), Univ Delaware, Sch Marine Sci & Policy, Lewes, DE 19958 USA.; Boyd, BM (reprint author), US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. EM brandon.m.boyd@usace.army.mil FU New Jersey Sea Grant (NJSG/NOAA Grant) [6210-0011]; U.S. Department of Defense SMART scholarship FX This study was funded by New Jersey Sea Grant (NJSG/NOAA Grant #6210-0011). B. Boyd was supported by a U.S. Department of Defense SMART scholarship. We thank Viktoria Unger for her assistance in the field and laboratory, Sarina Howell of the USGS New Jersey Water Science Center for providing water-level data, Troy Hill for the flooding frequency and duration R code provided in his Coastal wetlands and R blog, and Joe Gailani, Joe Kelley, Bill Ullman, and Joanna York for their comments on an earlier version of this manuscript. NR 73 TC 0 Z9 0 U1 4 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0025-3227 EI 1872-6151 J9 MAR GEOL JI Mar. Geol. PD JAN 1 PY 2017 VL 383 BP 132 EP 145 DI 10.1016/j.margeo.2016.11.008 PG 14 WC Geosciences, Multidisciplinary; Oceanography SC Geology; Oceanography GA EI8VR UT WOS:000392786800009 ER PT J AU Baruch, EN Kragh, JF Berg, AL Aden, JK Benov, A Shina, A Shlaifer, A Ahimor, A Glassberg, E Yitzhak, A AF Baruch, Erez N. Kragh, John F., Jr. Berg, Amy L. Aden, James K. Benov, Avi Shina, Avi Shlaifer, Amir Ahimor, Alon Glassberg, Elon Yitzhak, Avraham TI CONFIDENCE COMPETENCE MISMATCH AND REASONS FOR FAILURE OF NON-MEDICAL TOURNIQUET USERS SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE tourniquet; first aid; hemorrhage; prevention and control; caregivers; education; emergency medical services; tactical ID LIMB TRAUMA; ACCURACY AB Objective: Tourniquet application is a lifesaving skill taught worldwide in first aid bleeding control courses. We observed performance among non-medical users, of tourniquets in their confidence, competence, and reasons for failure. Methods: 179 Israeli military recruits without prior medical training underwent their standard first aid course where they learned Combat Application Tourniquet (CAT; Composite Resources, Rock Hill, SC, USA) use. After course completion, they self-reported confidence in tourniquet use. User performance was assessed 7-14 days later using a HapMed (TM) mannequin that assessed time, pressure, and blood loss. Competent performance required in aggregate: 1) use with pressure of 200 mmHg or more, 2) hemorrhage volume of less than 638 mL, and 3) correct placement of the tourniquet. For failed performance, a reason for failure was reported independently by both the user and an expert observer. Results: 45 of 179 user performances (25%) were competent. Users who reported high confidence had only a slightly higher chance of achieving competence in tourniquet application (r = 0.17, p = 0.022). The most common reason for failure was excess slack in the CAT's strap (experts 55%, users 39%), and too few turns of the windlass (23% and 31%, respectively) was the second most common reason. Expert and user evaluations had poor agreement (K = 0.44, 95% CI 0.32-0.56). Conclusion: The Most common reason for failed use of tourniquets among non-medical users was excess slack in the tourniquet strap. Users self-evaluated their performance inaccurately and demonstrated a confidence competence mismatch. These pitfalls in performance may help tourniquet instructors improve training of caregivers. C1 [Baruch, Erez N.; Berg, Amy L.; Benov, Avi; Shina, Avi; Shlaifer, Amir; Ahimor, Alon; Glassberg, Elon; Yitzhak, Avraham] Israel Def Forces Med Corps, Ramat Gan, Israel. [Kragh, John F., Jr.; Aden, James K.] US Army Inst Surg Res, Damage Control Resuscitat, JBSA, Ft Sam Houston, TX USA. [Benov, Avi] Meir Med Ctr, Dept Surg A, Kefar Sava, Israel. [Shina, Avi] Sheba Med Ctr, Talpiot Med Leadership Program, Ramat Gan, Israel. [Shlaifer, Amir] Tel Aviv Sourasky Med Ctr, Orthoped Div, Tel Aviv, Israel. RP Baruch, EN (reprint author), 13 Smilanski St, IL-7525869 Rishon Leziyyon, Israel. EM erez_br@yahoo.com OI Baruch, Erez Nissim/0000-0001-6001-6598 NR 31 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1090-3127 EI 1545-0066 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD JAN-FEB PY 2017 VL 21 IS 1 BP 39 EP 45 DI 10.1080/10903127.2016.1209261 PG 7 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA EJ0KR UT WOS:000392897800007 PM 27494564 ER PT J AU Skiba, AW Wabel, TM Carter, CD Hammack, SD Temme, JE Lee, T Driscoll, JF AF Skiba, Aaron W. Wabel, Timothy M. Carter, Campbell D. Hammack, Stephen D. Temme, Jacob E. Lee, Tonghun Driscoll, James F. TI Reaction layer visualization: A comparison of two PLIF techniques and advantages of kHz-imaging SO PROCEEDINGS OF THE COMBUSTION INSTITUTE LA English DT Article DE kHz-PLIF; CH-PLIF; Turbulent premixed combustion; Reaction layer imaging; Hi-pilot burner ID TURBULENT PREMIXED FLAMES; LASER-INDUCED FLUORESCENCE; HEAT-RELEASE; METHANE/AIR FLAMES; STEREOSCOPIC PIV; LOCAL FLAME; AIR FLAMES; OH-PLIF; COMBUSTION; CH AB Visualizing the structural features of turbulent premixed flames is critical for the validation of fundamen-tal combustion theories. This work compares two methods for visualizing reaction layers of flames. The first is planar laser-induced fluorescence (PLIF) of CH radicals. The second involves the product of simultaneously acquired PLIF images of hydroxyl radicals (OH) and formaldehyde molecules (CH2O) to generate "overlaplayers." Based on comparisons to CH-PLIF, the present work establishes the overlap-method as a practical technique for visualizing structural features of extremely turbulent flames (u'/S-L> 25). Specifically, both thin and thickened CH-and overlap-layers are observed in four flames of varying turbulence intensities (8 < u'/S-L < 64). Average overlap-and CH-layer thicknesses are found to exhibit the same trend with increasing turbulence levels. Furthermore, flame surface density (FSD) profiles derived from both techniques agree well. Specifically, their values are of the same magnitude and they decay at similar rates with increasing distance from centerline. Moreover, a parameter defined as the integral of the radial FSD-profiles is compared for the overlap-and CH-based measurements: differences between the two varied from 0.1% to approximately 20%. Such variation is considered small, since it is not greater than the estimated error in computing this parameter from the CH-based measurement. Finally, this study demonstrates the ability to acquire CH-PLIF images at a rate of 10 kHz within extremely turbulent flames. Results from such "high-speed" images demonstrate the ability to quantify the rate of flamelet-merging, which is an important quantity in models of turbulent premixed combustion. (C) 2016 by The Combustion Institute. Published by Elsevier Inc. C1 [Skiba, Aaron W.; Wabel, Timothy M.; Driscoll, James F.] Univ Michigan, Dept Aerosp Engn, 1320 Beal Ave, Ann Arbor, MI 48109 USA. [Carter, Campbell D.] US Air Force, Res Lab, Wright Patterson AFB, OH 45433 USA. [Hammack, Stephen D.; Lee, Tonghun] Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA. [Temme, Jacob E.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Skiba, AW (reprint author), Univ Michigan, Dept Aerosp Engn, 1320 Beal Ave, Ann Arbor, MI 48109 USA. EM skiba@umich.edu FU AFOSR [FA9550-12-1-0101] FX The authors thank AFOSR for including support through the project Grant FA9550-12-1-0101. NR 41 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1540-7489 EI 1873-2704 J9 P COMBUST INST JI Proc. Combust. Inst. PY 2017 VL 36 IS 3 BP 4593 EP 4601 DI 10.1016/j.proci.2016.07.033 PG 9 WC Thermodynamics; Energy & Fuels; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA EJ7OT UT WOS:000393412600142 ER PT J AU Emdadi, L Tran, DT Zhang, JY Wu, W Song, HM Gan, QQ Liu, DX AF Emdadi, Laleh Tran, Dat T. Zhang, Junyan Wu, Wei Song, Haomin Gan, Qiaoqiang Liu, Dongxia TI Synthesis of titanosilicate pillared MFI zeolite as an efficient photocatalyst SO RSC ADVANCES LA English DT Article ID 2-DIMENSIONAL ZEOLITES; CATALYTIC EPOXIDATION; LAMELLAR PRECURSOR; ACID CATALYSIS; MCM-36; PERSPECTIVES; MESOPOROSITY; DERIVATIVES; NANOSHEETS; OXIDATION AB A titanosilicate pillared MFI zeolite (abbreviated as Si/Ti-PMFI) has been synthesized by sequential infiltration of a mixed tetraethyl orthosilicate (TEOS) and tetrabutyl orthotitanate (TBOT) solvent into and hydrolysis of the TEOS/TBOT solvent entrapped between the multilamellar MFI layers. The Ti-species present in the titanosilicate pillars, acid sites supplied by the framework Al-O(H)-Si sites in MFI layers, and mesoporosity collectively endow Si/Ti-PMFI with efficient adsorption assisted photocatalytic functionality, which was exemplified by the degradation of methyl orange (MO) in water. The synthesis of Si/Ti-PMFI zeolites containing Al-O(H)-Si acid sites within MFI layers and Ti-sites between layers diversified the structure, physicochemical properties, and catalytic functionality of hierarchical lamellar zeolites. The Si/Ti-PMFI lamellar zeolites were studied as adsorptive catalysts for photocatalysis, especially when bulky molecules are involved. C1 [Emdadi, Laleh; Zhang, Junyan; Wu, Wei; Liu, Dongxia] Univ Maryland, Dept Chem & Biomol Engn, 4418 Stadium Dr, College Pk, MD 20742 USA. [Tran, Dat T.] US Army Res Lab, RDRL SEC C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Song, Haomin; Gan, Qiaoqiang] Univ Buffalo, Dept Elect Engn, 230 M Davis Hall, Buffalo, NY 14260 USA. RP Liu, DX (reprint author), Univ Maryland, Dept Chem & Biomol Engn, 4418 Stadium Dr, College Pk, MD 20742 USA. EM liud@umd.edu FU Army Research Laboratory [5284201]; National Science Foundation [NSF-CBET 1264599, 1351384]; Maryland NanoCenter; AIMLab; University of Maryland Energy Research Center (UMERC) FX The authors gratefully acknowledge financial support from the Army Research Laboratory (5284201) and National Science Foundation (NSF-CBET 1264599, 1351384). We acknowledge the support of Maryland NanoCenter and its AIMLab. Laleh Emdadi thanks for the Harry K. Wells Energy Research Fellowship from University of Maryland Energy Research Center (UMERC) to support her research. NR 53 TC 0 Z9 0 U1 6 U2 6 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2046-2069 J9 RSC ADV JI RSC Adv. PY 2017 VL 7 IS 6 BP 3249 EP 3256 DI 10.1039/c6ra23959e PG 8 WC Chemistry, Multidisciplinary SC Chemistry GA EK2HU UT WOS:000393749200025 ER PT J AU Brager, AJ Heemstra, L Bhambra, R Ehlen, JC Esser, KA Paul, KN Novak, CM AF Brager, Allison J. Heemstra, Lydia Bhambra, Raman Ehlen, J. Christopher Esser, Karyn A. Paul, Ketema N. Novak, Colleen M. TI Homeostatic effects of exercise and sleep on metabolic processes in mice with an overexpressed skeletal muscle clock SO BIOCHIMIE LA English DT Article DE Insulin sensitivity; Resting energy expenditure; VO2 max; Restricted sleep; Treadmill running; Molecular circadian clock ID MAMMALIAN CIRCADIAN CLOCK; SEX-CHROMOSOMES; BMAL1; COMPONENT AB Brain and muscle-ARNT-like factor (Bmal1/BMAL1) is an essential transcriptional/translational factor of circadian clocks. Loss of function of Bma1/BMAL1 is highly disruptive to physiological and behavioral processes. In light of these previous findings, we examined if transgenic overexpression of Bmal1/BMAL1 in skeletal muscle could alter metabolic processes. First, we characterized in vivo and ex vivo metabolic phenotypes of muscle overexpressed mice (male and female) compared to wild-type littermates (WT). Second, we examined in vivo and ex vivo metabolic processes in the presence of positive and negative homeostatic challenges: high-intensity treadmill running (positive) and acute sleep deprivation (negative). In vivo measures of metabolic processes included body composition, respiratory exchange ratio (RER; VCO2/VO2), energy expenditure, total activity counts, and food intake collected from small animal indirect calorimetry. Ex vivo measure of insulin sensitivity in skeletal muscle was determined from radioassays. RER was lower for muscle overexpressed females compared to female WTs. There were no genotype-dependent differences in metabolic phenotypes for males. With homeostatic challenges, muscle overexpressed mice had lower energy expenditure after high-intensity treadmill running. Acute sleep deprivation reduced insulin sensitivity in skeletal muscle in overexpressed male mice, but not male WTs. The present study contributes to a body of evidence showing pleiotropic, non-circadian, and homeostatic effects of altered Bmal1/BMAL1 expression on metabolic processes, demonstrating a critical need to further investigate the broad and complex actions of Bmal1/BMAL1 on physiology and behavior. Published by Elsevier B.V. C1 [Brager, Allison J.] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD 20910 USA. [Heemstra, Lydia; Bhambra, Raman; Novak, Colleen M.] Kent State Univ, Dept Biol Sci, Kent, OH 44242 USA. [Heemstra, Lydia; Bhambra, Raman; Novak, Colleen M.] Kent State Univ, Sch Biomed Sci, Kent, OH 44242 USA. [Ehlen, J. Christopher] Morehouse Sch Med, Dept Neurobiol, Atlanta, GA 30310 USA. [Esser, Karyn A.] Univ Florida, Coll Med, Dept Physiol & Funct Genom, Gainesville, FL 32611 USA. [Paul, Ketema N.] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA USA. EM allison.j.bragen.ctr@mail.mil FU [F32HL116077]; [1R01AR066082]; [U54NS083932]; [R01NS078410]; [R15DK097644]; [R15DK108668]; [AHA GRNT12050566] FX This work was performed at Kent State University in Kent, OH and Morehouse School of Medicine in Atlanta, GA. Funding to Dr. Brager from F32HL116077. Funding to Dr. Esser from 1R01AR066082. Funding to Dr. Ketema Paul from U54NS083932, R01NS078410. Funding to Dr. Colleen Novak, Lydia Heemstra, and Rama Bhambra from R15DK097644, R15DK108668, AHA GRNT12050566. NR 26 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0300-9084 EI 1638-6183 J9 BIOCHIMIE JI Biochimie PD JAN PY 2017 VL 132 BP 161 EP 165 DI 10.1016/j.biochi.2016.11.014 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EI7OJ UT WOS:000392687300017 PM 27916643 ER PT J AU Gregory, E West, TA Cole, WR Bailie, JM McCulloch, KL Ettenhofer, ML Cecchini, A Qashu, FM AF Gregory, Emma West, Therese A. Cole, Wesley R. Bailie, Jason M. McCulloch, Karen L. Ettenhofer, Mark L. Cecchini, Amy Qashu, Felicia M. TI Use of a multi-level mixed methods approach to study the effectiveness of a primary care progressive return to activity protocol after acute mild traumatic brain injury/concussion in the military SO CONTEMPORARY CLINICAL TRIALS LA English DT Article DE Clinical study methodology; Outcomes research; Traumatic brain injury; Concussion; Knowledge translation; Military ID CONCUSSION MANAGEMENT; SERVICE MEMBERS; SYMPTOMS; INJURY; IMPACT; SPORT; REST; RECOMMENDATIONS; INTERVENTION; COMPLAINTS AB The large number of U.S. service members diagnosed with concussion/mild traumatic brain injury each year underscores the necessity for clear and effective clinical guidance for managing concussion. Relevant research continues to emerge supporting a gradual return to pre-injury activity levels without aggravating symptoms; however, available guidance does not provide detailed standards for this return to activity process. To fill this gap, the Defense and Veterans Brain Injury Center released a recommendation for primary care providers detailing a step-wise return to unrestricted activity during the acute phase of concussion. This guidance was developed in collaboration with an interdisciplinary group of clinical, military, and academic subject matter experts using an evidence-based approach. Systematic evaluation of the guidance is critical to ensure positive patient outcomes, to discover barriers to implementation by providers, and to identify ways to improve the recommendation. Here we describe a multi-level, mixed-methods approach to evaluate the recommendation incorporating outcomes from both patients and providers. Procedures were developed to implement the study within complex but ecologically-valid settings at multiple military treatment facilities and operational medical units. Special consideration was given to anticipated challenges such as the frequent movement of military personnel, selection of appropriate design and measures, study implementation at multiple sites, and involvement of multiple service branches (Army, Navy, and Marine Corps). We conclude by emphasizing the need to consider contemporary approaches for evaluating the effectiveness of clinical guidance. (C) 2016 Elsevier Inc. All rights reserved. C1 [Gregory, Emma; Cole, Wesley R.; Bailie, Jason M.; Ettenhofer, Mark L.; Cecchini, Amy; Qashu, Felicia M.] Def & Vet Brain Injury Ctr, 1335 East West Highway, Silver Spring, MD 20910 USA. [Gregory, Emma; Cole, Wesley R.; Bailie, Jason M.] Gen Dynam Hlth Solut, 8601 Georgia Ave Ste 900, Silver Spring, MD 20910 USA. [West, Therese A.] US Army Med Res & Mat Command, Combat Casualty Care Res Program, 722 Doughten St, Ft Detrick, MD 21792 USA. [Cole, Wesley R.] Womack Army Med Ctr, MIXC TBI 2817 Reilly Rd, Ft Bragg, NC 28310 USA. [Bailie, Jason M.] Naval Hosp Camp Pendleton, 33 Area,Mental Hlth Bldg 33305, Camp Pendleton, CA 92055 USA. [McCulloch, Karen L.] Univ North Carolina Chapel Hill, 321 S Columbia St,Bondurant Hall Ste 3024, Chapel Hill, NC 27599 USA. [McCulloch, Karen L.; Cecchini, Amy] Venesco LLC, 14801 Murdock St Suite 125, Chantilly, VA 20151 USA. [Ettenhofer, Mark L.] Naval Med Ctr San Diego, Dept Phys Med & Rehabil, 34730 Bob Wilson Dr Ste 201 Bldg 3, San Diego, CA 92134 USA. [Ettenhofer, Mark L.] Amer Hosp Serv Grp LLC, 1 E Uwchlan Ave,Suite 407, Exton, PA 19341 USA. EM emma.d.gregory2.ctr@mail.mil FU Defense Health Program [6.7]; Defense and Veterans Brain Injury Center FX This work was supported by the Defense Health Program 6.7 and the Defense and Veterans Brain Injury Center. NR 31 TC 0 Z9 0 U1 6 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1551-7144 EI 1559-2030 J9 CONTEMP CLIN TRIALS JI Contemp. Clin. Trials PD JAN PY 2017 VL 52 BP 95 EP 100 DI 10.1016/j.cct.2016.11.005 PG 6 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA EI5VZ UT WOS:000392565700013 PM 27836507 ER PT J AU Cecotti, H Ries, AJ AF Cecotti, Hubert Ries, Anthony J. TI Best practice for single-trial detection of event-related potentials: Application to brain-computer interfaces SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY LA English DT Article DE Event-related potentials; Brain-computer Interface; Biomedical engineering; Spatial filtering; Multivariate pattern analysis; Classification ID INDEPENDENT COMPONENT ANALYSIS; SERIAL VISUAL PRESENTATION; MENTAL CHRONOMETRY; ERP COMPONENTS; IMAGE SEARCH; P300; CLASSIFICATION; EEG; BCI; CONSCIOUSNESS AB The detection of event-related potentials (ERPs) in the electroencephalogram (EEG) signal is a fundamental component in non-invasive brain-computer interface (BCI) research, and in modern cognitive neuroscience studies. Whereas the grand average response across trials provides an estimation of essential characteristics of a brain evoked response, an estimation of the differences between trials for a particular type of stimulus can provide key insight about the brain dynamics and possible origins of the brain response. The research in ERP single trial detection has been mainly driven by applications in biomedical engineering, with an interest from machine learning and signal processing groups that test novel methods on noisy signals. Efficient single-trial detection techniques require processing steps that include temporal filtering, spatial filtering, and classification. In this paper, we review the current state-of-the-art methods for single-trial detection of event-related potentials with applications in BCI. Efficient single-trial detection techniques should embed simple yet efficient functions requiring as few hyper-parameters as possible. The focus of this paper is on methods that do not include a large number of hyper-parameters and can be easily implemented with datasets containing a limited number of trials. A benchmark of different classification methods is proposed on a database recorded from sixteen healthy subjects during a rapid serial visual presentation task. The results support the conclusion that single-trial detection can be achieved with an area under the ROC curve superior to 0.9 with less than ten sensors and 20 trials corresponding to the presentation of a target. Whereas the number of sensors is not a key element for efficient single-trial detection, the number of trials must be carefully chosen for creating a robust classifier. (C) 2016 Elsevier B.V. All rights reserved. C1 [Cecotti, Hubert] Univ Ulster, Fac Comp & Engn, Magee Campus, Coleraine BT48 7JL, Londonderry, North Ireland. [Ries, Anthony J.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM h.cecotti@ulster.ac.uk FU Institute for Collaborative Biotechnologies through U.S. Army Research Office [W911NF-09-D-0001]; InvestNI [1303/101154803]; UI-ster University FX This research was supported by the Institute for Collaborative Biotechnologies through contract W911NF-09-D-0001 from the U.S. Army Research Office. HC would like to thank the NI Functional Brain Mapping Facility project (1303/101154803) funded by InvestNI and UI-ster University. NR 80 TC 1 Z9 1 U1 5 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-8760 EI 1872-7697 J9 INT J PSYCHOPHYSIOL JI Int. J. Psychophysiol. PD JAN PY 2017 VL 111 SI SI BP 156 EP 169 DI 10.1016/j.ijpsycho.2016.07.500 PG 14 WC Psychology, Biological; Neurosciences; Physiology; Psychology; Psychology, Experimental SC Psychology; Neurosciences & Neurology; Physiology GA EI5SJ UT WOS:000392554600013 PM 27453051 ER PT J AU Chudnovsky, AA Koutrakis, P Kostinski, A Proctor, SP Garshick, E AF Chudnovsky, A. Alexandra Koutrakis, Petros Kostinski, Alex Proctor, Susan P. Garshick, Eric TI Spatial and temporal variability in desert dust and anthropogenic pollution in Iraq, 1997-2010 SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID AEROSOL OPTICAL DEPTH; FINE PARTICULATE MATTER; OZONE MONITORING INSTRUMENT; DAILY EMERGENCY ADMISSIONS; STORM EVENTS; HOSPITAL ADMISSIONS; AIR-POLLUTION; RESPIRATORY SYMPTOMS; PM2.5 CONCENTRATIONS; EXPOSURE ASSESSMENT AB Satellite imaging has emerged as a method for monitoring regional air pollution and detecting areas of high dust concentrations. Unlike ground observations, continuous data monitoring is available with global coverage of terrestrial and atmospheric components. In this study we test the utility of different sources of satellite data to assess air pollution concentrations in Iraq. SeaWiFS and MODIS Deep Blue (DB) aerosol optical depth (AOD) products were evaluated and used to characterize the spatial and temporal pollution levels from the late 1990s through 2010. The AOD and Angstrom exponent (an indicator of particle size, since smaller Angstrom exponent values reflect a source that includes larger particles) were correlated on 50 x 50 km spatial resolution. Generally, AOD and Angstrom exponent were inversely correlated, suggesting a significant contribution of coarse particles from dust storms to AOD maxima. Although the majority of grid cells exhibited this trend, a weaker relationship in other locations suggested an additional contribution of fine particles from anthropogenic sources. Tropospheric NO2 densities from the OMI satellite were elevated over cities, also consistent with a contribution from anthropogenic sources. Our analysis demonstrates the use of satellite imaging data to estimate relative pollution levels and source contributions in areas of the world where direct measurements are not available. Implications: The authors demonstrated how satellite data can be used to characterize exposures to dust and to anthropogenic pollution for future health related studies. This approach is of a great potential to investigate the associations between subject-specific exposures to different pollution sources and their health effects in inaccessible regions and areas where ground monitoring is unavailable. C1 [Chudnovsky, A. Alexandra] Tel Aviv Univ, Dept Geog & Human Environm, Tel Aviv, Israel. [Chudnovsky, A. Alexandra; Koutrakis, Petros] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Kostinski, Alex] Michigan Technol Univ, Houghton, MI 49931 USA. [Proctor, Susan P.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA. [Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Proctor, Susan P.] VA Boston Healthcare Syst, Res Serv, Boston, MA USA. [Garshick, Eric] VA Boston Healthcare Syst, Med Serv, Pulm Allergy Sleep & Crit Care Med Sect, Boston, MA USA. [Garshick, Eric] Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Boston, MA USA. EM achudnov@hsph.harvard.edu FU U.S. Department of Veterans Affairs, Office of Research and Development, Clinical Science Research and Development, Cooperative Studies Program, U.S. Environmental Protection Agency (EPA) grant [RD 83479801]; National Science Foundation [AGS-111916] FX This work is supported by the U.S. Department of Veterans Affairs, Office of Research and Development, Clinical Science Research and Development, Cooperative Studies Program, U.S. Environmental Protection Agency (EPA) grant RD 83479801, and National Science Foundation Grant AGS-111916. Its contents are solely the responsibility of the authors and do not represent the official views of the EPA, U.S. Department of Veterans Affairs, or the U.S. Department of Defense/Army. Further, EPA, U.S. Department of Veterans Affairs, and the U.S. Department of Defense/Army do not endorse the purchase of any commercial products or services mentioned in the publication. NR 69 TC 1 Z9 1 U1 5 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1096-2247 EI 2162-2906 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PY 2017 VL 67 IS 1 BP 17 EP 26 DI 10.1080/10962247.2016.1153528 PG 10 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EI7ED UT WOS:000392659700003 PM 28001122 ER PT J AU Corey, BW Thompson, MG Hittle, LE Jacobs, AC Asafo-Adjei, EA Huggins, WM Melander, RJ Melander, C Ernst, RK Zurawski, DV AF Corey, Brendan W. Thompson, Mitchell G. Hittle, Lauren E. Jacobs, Anna C. Asafo-Adjei, Edward A. Huggins, William M. Melander, Roberta J. Melander, Christian Ernst, Robert K. Zurawski, Daniel V. TI 1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens SO ACS INFECTIOUS DISEASES LA English DT Article DE ESKAPE pathogens; fatty acids; antibiotic; antibacterial; fungi; Gram-negative membrane ID INFECTIOUS-DISEASES SOCIETY; FATTY-ACID BIOSYNTHESIS; ANTIBIOTIC-RESISTANCE; GENOMIC ANALYSIS; BAD BUGS; DRUGS; YEAST; DIVERSIFICATION; INHIBITORS; EPIDEMIC AB Acinetobacter baumannii are Gram-negative bacilli that pose a constant threat to susceptible patients because of increased resistance to multiple antibiotics and persistence in the hospital environment. After genome analysis, we discovered that A. baumannii harbors genes that share homology to an enzymatic pathway that elongates long-chain fatty acids (LCFA) in fungi. Previously, 1,2,4-triazolidine-3-thiones (T-3-Ts) were shown to inhibit hyphae production in fungi, and this same LCFA elongation pathway was implicated as the possible target. Therefore, we investigated if T-3-Ts also have activity against multidrug-resistant A. baumannii. Surprisingly, all of the clinical isolates of A. baumannii that were tested have susceptibility to ECC145 and ECC188 with MIC90 values of 8.0 mu g/mL. In contrast, reference strains and clinical isolates of other common nosocomial bacteria that lack the LCFA pathway also lacked susceptibility. Time kill experiments revealed that both ECC145 and ECC188 have a bacteriostatic effect against A. baumannii. Mass spectrometry analysis suggested that exposure to T-3-Ts resulted in less LCFA production. Supplementation of media with either 0.02% w/v oleic or linoleic acid abrogated the bacteriostatic effect of the compounds, which again implicated LCFA elongation as the target. Our results suggest these molecules could be a promising start to further exploit what appears to be an important aspect of A. baumannii membrane function and integrity. C1 [Corey, Brendan W.; Thompson, Mitchell G.; Jacobs, Anna C.; Zurawski, Daniel V.] Walter Reed Army Inst Res, Bacterial Dis Branch, Wound Infect Dept, Silver Spring, MD 20910 USA. [Hittle, Lauren E.; Ernst, Robert K.] Univ Maryland, Sch Dent, Dept Microbial Pathogenesis, Baltimore, MD 21201 USA. [Asafo-Adjei, Edward A.] Walter Reed Army Inst Res, Dept Vet Med, Silver Spring, MD 20910 USA. [Huggins, William M.; Melander, Roberta J.; Melander, Christian] North Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA. RP Zurawski, DV (reprint author), Walter Reed Army Inst Res Bacterial Dis, Wound Infect Dept, Rm 3A45,2460 Linden Lane,Bldg 503, Silver Spring, MD 20910 USA. EM daniel.v.zurawski.ctr@mail.mil FU Military Infectious Diseases Research Program [W0136_15_WR]; NIH [GM055769] FX B.W.C., M.G.T., A.C.J., E.A.A.-A., and D.V.Z. were supported by W0136_15_WR, a grant from the Military Infectious Diseases Research Program. W.M.H., R.J.M., and C.M. were supported by NIH Grant GM055769. NR 30 TC 1 Z9 1 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 2373-8227 J9 ACS INFECT DIS JI ACS Infect. Dis. PD JAN PY 2017 VL 3 IS 1 BP 62 EP 71 DI 10.1021/acsinfecdis.6b00133 PG 10 WC Chemistry, Medicinal; Infectious Diseases SC Pharmacology & Pharmacy; Infectious Diseases GA EI1TH UT WOS:000392260300007 PM 27764938 ER PT J AU Huggins, WM Minrovic, BM Corey, BW Jacobs, AC Melander, RJ Sommer, RD Zurawski, DV Melander, C AF Huggins, William M. Minrovic, Bradley M. Corey, Brendan W. Jacobs, Anna C. Melander, Roberta J. Sommer, Roger D. Zurawski, Daniel V. Melander, Christian TI 1,2,4-Triazolidine-3-thiones as Narrow Spectrum Antibiotics against Multidrug-Resistant Acinetobacter baumannii SO ACS MEDICINAL CHEMISTRY LETTERS LA English DT Article DE antibiotic resistance; antibiotics; Acinetobacter baumannii ID INFECTIONS; PARADIGM AB With only two new classes of antibiotics developed in the last 40 years, novel antibiotics are desperately needed to combat the growing problem of multidrug-resistant and extensively drug resistant bacteria, particularly Gram-negative bacteria. Described in this letter is the synthesis and antibiotic activity of 1,2,4-triazolidine-3-thiones as narrow spectrum antibiotics. Optimization of the 1,2,4-triazolidine-3-thione scaffold identified a small molecule with potent antibiotic activity against multiple strains of multidrug-resistant and extensively drug resistant Acinetobacter baumannii. This small molecule also shows single dose, in vivo activity in a Galleria mellonella infection model with A. baumannii and represents a promising start in the development of a class of drugs that can target this bacterial pathogen. C1 [Huggins, William M.; Minrovic, Bradley M.; Melander, Roberta J.; Sommer, Roger D.; Melander, Christian] North Carolina State Univ, Dept Chem, 2620 Yarbrough Dr, Raleigh, NC 27695 USA. [Corey, Brendan W.; Jacobs, Anna C.; Zurawski, Daniel V.] Walter Reed Army Inst Res, Wound Infect Dept, Silver Spring, MD 20910 USA. RP Melander, C (reprint author), North Carolina State Univ, Dept Chem, 2620 Yarbrough Dr, Raleigh, NC 27695 USA. EM ccmeland@ncsu.edu FU N.C. State FX The authors from N.C. State would like to thank the university for support. The authors from Wound Infection Department at WRAIR would like to acknowledge the constant support of the Military Infectious Diseases Research Program. NR 23 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-5875 J9 ACS MED CHEM LETT JI ACS Med. Chem. Lett. PD JAN PY 2017 VL 8 IS 1 BP 27 EP 31 DI 10.1021/acsmedchemlett.6b00296 PG 5 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA EH8UM UT WOS:000392047900004 PM 28105270 ER PT J AU Suedel, BC Wilkens, JL Kennedy, AJ AF Suedel, Burton C. Wilkens, Justin L. Kennedy, Alan J. TI Effects of Suspended Sediment on Early Life Stages of Smallmouth Bass (Micropterus dolomieu) SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID PARENTAL CARE; WATER-QUALITY; TURBIDITY; EGGS; SELECTIVITY; SURVIVAL; BEHAVIOR; IMPACTS; DEFENSE; SUCCESS AB The resuspension of sediments caused by activities, such as dredging operations, is a concern in Great Lakes harbors where multiple fish species spawn. To address such concerns, smallmouth bass (Micropterus dolomieu) were exposed to uncontaminated suspended sediment (nominally 0, 100, 250, and 500 mg/L) continuously for 72 h to determine the effects on egg-hatching success and swim-up fry survival and growth. The test sediments were collected from two harbors: (1) fine-grained sediment in Grand Haven Harbor, Lake Michigan, and (2) coarser-grained sediment in Fairport Harbor, Lake Erie. Eggs exposed to total suspended solids (TSS) concentrations > 100 mg/L resulted in decreased survival of post-hatch larval fish. Fry survival was > 90 % at the highest exposure concentration (500 mg/L), but growth was decreased when the exposure concentration was > 100 mg/L. Growth and survival of swim-up fry held for a 7- and 26-day post-exposure the grow-out period was variable suggesting that the sediment grain size and strain of fish may influence lingering effects after the cessation of exposure. The results suggest that exposed eggs hatched normally; however, newly hatched larvae, which are temporarily immobile, are more vulnerable to the effects of suspended sediment. The swim-up fry were found to be more sensitive to high TSS concentrations in sandy relative to silty sediment. These data represent a conservative exposure scenario that can be extrapolated to high-energy systems in the field to inform management decisions regarding the necessity for dredging windows or need to implement controls to protect M. dolomieu. C1 [Suedel, Burton C.; Wilkens, Justin L.; Kennedy, Alan J.] US Army, Engn Res & Dev Ctr, Corps Engineers, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. RP Suedel, BC (reprint author), US Army, Engn Res & Dev Ctr, Corps Engineers, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM burton.suedel@usace.army.mil; justin.l.wilkens@usace.army.mil; alan.j.kennedy@usace.army.mil FU Corps of Engineers Buffalo District; Dredging Operations and Environmental Research Program FX We thank Reese Sparrow at the John D. Parker East Texas State Fish Hatchery and Steve Krueger at the Jake Wolf Memorial Fish Hatchery, Topeka, IL, and their staffs for their assistance in providing eggs. We thank Scott Pickard of the Buffalo District and Hal Harrington of the Detroit District Corps of Engineers for the coordination of sediment collection and their review of an earlier version of the paper, Jacob Stanley for the swimming behavior analyses, and Jack Grogan and Robert Boyd for expert technical assistance. This research was funded by the Corps of Engineers Buffalo District and the Dredging Operations and Environmental Research Program, Todd Bridges, Director. Permission was granted by the Chief of Engineers to publish this material. NR 42 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0090-4341 EI 1432-0703 J9 ARCH ENVIRON CON TOX JI Arch. Environ. Contam. Toxicol. PD JAN PY 2017 VL 72 IS 1 BP 119 EP 131 DI 10.1007/s00244-016-0322-4 PG 13 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EI2GR UT WOS:000392305400011 PM 27778053 ER PT J AU Wu, HC Quan, DN Tsao, CY Liu, Y Terrell, JL Luo, XL Yang, JC Payne, GF Bentley, WE AF Wu, Hsuan-Chen Quan, David N. Tsao, Chen-Yu Liu, Yi Terrell, Jessica L. Luo, Xiaolong Yang, Jen-Chang Payne, Gregory F. Bentley, William E. TI Conferring Biological Activity to Native Spider Silk: A Biofunctionalized Protein-Based Microfiber SO BIOTECHNOLOGY AND BIOENGINEERING LA English DT Article DE biofabrication; biofunctionalization; spider silk; microfluidics ID GREEN FLUORESCENT PROTEIN; NEPHILA-CLAVIPES; DRAGLINE SILK; ESCHERICHIA-COLI; PREY CAPTURE; TRANSGLUTAMINASE; SIGNALS; GELATIN; SPECTRA; FIBERS AB Spider silk is an extraordinary material with physical properties comparable to the best scaffolding/structural materials, and as a fiber it can be manipulated with ease into a variety of configurations. Our work here demonstrates that natural spider silk fibers can also be used to organize biological components on and in devices through rapid and simple means. Micron scale spider silk fibers (5-10 mu m in diameter) were surface modified with a variety of biological entities engineered with pentaglutamine tags via microbial transglutaminase (mTG). Enzymes, enzyme pathways, antibodies, and fluorescent proteins were all assembled onto spider silk fibers using this biomolecular engineering/biofabrication process. Additionally, arrangement of biofunctionalized fiber should in of itself generate a secondary level of biomolecular organization. Toward this end, as proofs of principle, spatially defined arrangement of biofunctionalized spider silk fiber was shown to generate effects specific to silk position in two cases. In one instance, arrangement perpendicular to a flow produced selective head and neck carcinoma cell capture on silk with antibodies complexed to conjugated protein G. In a second scenario, asymmetric bacterial chemotaxis arose from asymmetric conjugation of enzymes to arranged silk. Overall, the biofabrication processes used here were rapid, required no complex chemistries, were biologically benign, and also the resulting engineered silk microfibers were flexible, readily manipulated and functionally active. Deployed here in microfluidic environments, biofunctional spider silk fiber provides a means to convey complex biological functions over a range of scales, further extending its potential as a biomaterial in biotechnological settings. (C) 2016 Wiley Periodicals, Inc. C1 [Wu, Hsuan-Chen] Natl Taiwan Univ, Dept Biochem Sci & Technol, Taipei, Taiwan. [Quan, David N.; Liu, Yi; Payne, Gregory F.; Bentley, William E.] Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA. [Tsao, Chen-Yu; Payne, Gregory F.; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. [Terrell, Jessica L.] US Army, Res Lab, Adelphi, MD USA. [Luo, Xiaolong] Catholic Univ Amer, Dept Mech Engn, Washington, DC 20064 USA. [Yang, Jen-Chang] Taipei Med Univ, Sch Dent Technol, Taipei, Taiwan. RP Bentley, WE (reprint author), Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA.; Bentley, WE (reprint author), Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. EM bentley@umd.edu FU National Science Foundation [CBET 1264509, CBET 1160005, DMREF 1435957]; Defense Threat Reduction Agency [HDTRA1-13-1-0037]; Robert W. Deutsch Foundation FX Contract grant sponsor: National Science Foundation; Contract grant numbers: CBET 1264509; CBET 1160005; DMREF 1435957; Contract grant sponsor: Defense Threat Reduction Agency; Contract grant number: HDTRA1-13-1-0037; Contract grant sponsor: Robert W. Deutsch Foundation. NR 51 TC 0 Z9 0 U1 7 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0006-3592 EI 1097-0290 J9 BIOTECHNOL BIOENG JI Biotechnol. Bioeng. PD JAN PY 2017 VL 114 IS 1 BP 83 EP 95 DI 10.1002/bit.26065 PG 13 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA EI5MQ UT WOS:000392539400009 PM 27478042 ER PT S AU Jenket, DR Forster, AM Paulter, NG Weerasooriya, T Gunnarsson, CA Al-Sheikhly, M AF Jenket, Donald R., II Forster, Amanda M. Paulter, Nick G., Jr. Weerasooriya, Tusit Gunnarsson, Carey A. Al-Sheikhly, Mohamad BE Antoun, B Arzoumanidis, A Qi, HJ Silberstein, M Amirkhizi, A Furmanski, J Lu, H TI An Investigation of the Temperature and Strain-Rate Effects on Strain-to-Failure of UHMWPE Fibers SO CHALLENGES IN MECHANICS OF TIME DEPENDENT MATERIALS, VOL 2 SE Conference Proceedings of the Society for Experimental Mechanics Series LA English DT Proceedings Paper CT SEM Annual Conference and Exposition on Experimental and Applied Mechanics CY JUN 06-09, 2016 CL Orlando, FL SP Soc Expt Mech DE UHMWPE single fiber; Strain-to-failure; Split-Hopkinson Tension Bar (SHTB); Kolsky bar; Single fiber heater ID STATISTICAL-ANALYSIS AB During a ballistic impact, Ultra High Molecular Weight Polyethylene (UHMWPE) fibers are subjected to high temperatures and high strain-rates. Their tensile strength increases with increasing strain-rate and decreases with increasing temperature. To understand the impact of both factors simultaneously, a single fiber heater has been fabricated to heat UHMWPE fibers up to the melting temperature (similar to 148 degrees C) to measure the change in mechanical properties as a function of temperature and strain-rate. Custom grips have been fabricated for use with the single fiber heater and performed well across all strain rates and temperatures in this study. 251 tensile tests have been conducted on 10-mm gage length UHMWPE single fibers at temperature-strain-rate combinations spanning five strain-rates between 10(-3) and 550 s(-1) and 11 temperatures from 20 to 148 degrees C. A non-failure boundary is created by temperature-strain-rate combinations where fibers can be strained to 25 % without mechanically failing. This occurs at 75 degrees C for 10(-3) s(-1), 100 degrees C for 10(-2) s(-1), 130 degrees C for 10(-1) s(-1), 148 degrees C for 10(0) s(-1), and fail regardless of temperature at 55(0) s(-1). It is estimated that for similar mechanical response, an increase in temperature of 25-30 degrees C is equivalent to lowering the strain-rate by one decade for strain-rates between 10(-3) and 10(-1) s(-1). At 550 s(-1) strain-rate, there was minor change in the strain-to-failure from 20 to 145 degrees C indicating strain-rate is the dominant factor. C1 [Jenket, Donald R., II; Forster, Amanda M.; Paulter, Nick G., Jr.] NIST, M-S 8102 100 Bur Dr, Gaithersburg, MD 20899 USA. [Weerasooriya, Tusit; Gunnarsson, Carey A.] Army Res Lab, WRMD, Aberdeen Proving Ground, MD 21005 USA. [Al-Sheikhly, Mohamad] Univ Maryland, Dept Mat Sci & Engn, 4418 Stadium Dr, College Pk, MD 20742 USA. RP Jenket, DR (reprint author), NIST, M-S 8102 100 Bur Dr, Gaithersburg, MD 20899 USA. EM donald.jenket@nist.gov OI Forster, Amanda/0000-0001-7397-4429 NR 12 TC 0 Z9 0 U1 5 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 2191-5644 BN 978-3-319-41543-7; 978-3-319-41542-0 J9 C PROC SOC EXP MECH PY 2017 BP 23 EP 33 DI 10.1007/978-3-319-41543-7_4 PG 11 WC Engineering, Mechanical; Materials Science,