FN Thomson Reuters Web of Science™ VR 1.0 PT J AU MARSHALL, MS BENNER, RE AF MARSHALL, MS BENNER, RE TI SIZING OPAQUE SPHERICAL-PARTICLES USING CLASSICAL MATCHED-FILTERS AND HOLOGRAPHIC RING DETECTORS SO OPTICAL ENGINEERING LA English DT Article DE INFORMATION PROCESSING; PARTICLE SIZING; OPTICAL CORRELATION ID OPTICAL-PATTERN RECOGNITION; COMPUTER-GENERATED HOLOGRAM AB Two optical pattern recognition methods for characterizing spherical and nonspherical aerosols and particulates are presented. The overall objective of size distribution determination in nearly real time under conditions of high particulate loading is specified. A holographic version of the commercially available wedge-ring detector is described to replace the classical matched filter and some of the possible benefits are enumerated. Computer simulations utilizing the classical matched filter and the holographic ring detector and experimental data collected for opaque spherical particles are included. C1 UNIV UTAH,DEPT ELECT ENGN,SALT LAKE CITY,UT 84112. RP MARSHALL, MS (reprint author), USA,DUGWAY PROVING GROUND,INSTRUMENTAT BRANCH,DUGWAY PROVING GROUND,UT 84022, USA. NR 23 TC 17 Z9 17 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAY PY 1992 VL 31 IS 5 BP 947 EP 955 DI 10.1117/12.56161 PG 9 WC Optics SC Optics GA HU370 UT WOS:A1992HU37000010 ER PT J AU KIRSCH, JC GREGORY, DA THIE, MW JONES, BK AF KIRSCH, JC GREGORY, DA THIE, MW JONES, BK TI MODULATION CHARACTERISTICS OF THE EPSON LIQUID-CRYSTAL TELEVISION SO OPTICAL ENGINEERING LA English DT Article DE INFORMATION PROCESSING; LIQUID CRYSTAL TELEVISIONS; PHASE MODULATION; AMPLITUDE MODULATION ID SPATIAL LIGHT-MODULATOR; OPTICAL CORRELATOR AB The amplitude- and phase-modulating properties of liquid crystal televisions (LCTVs) are becoming increasingly well known. The Epson Crystal Image video projector is a relatively new TV and uses three liquid crystal panels to encode the red, green, and blue components of the video signal onto the projector light. These panels can be removed for use in optical systems. We present the results from measurements of the phase- and amplitude-modulation properties of one of these LCTV panels. RP KIRSCH, JC (reprint author), USA,MISSILE COMMAND,AMSMI RD WS PO,REDSTONE ARSENAL,AL 35898, USA. NR 14 TC 87 Z9 90 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAY PY 1992 VL 31 IS 5 BP 963 EP 970 DI 10.1117/12.56170 PG 8 WC Optics SC Optics GA HU370 UT WOS:A1992HU37000012 ER PT J AU STEINBAUM, SS PEARL, RH KRANSDORF, M AF STEINBAUM, SS PEARL, RH KRANSDORF, M TI NONOPERATIVE THERAPY OF A COMPLICATED BILIARY STRICTURE SO PEDIATRIC SURGERY INTERNATIONAL LA English DT Article DE BILE DUCT OBSTRUCTION; DRAINAGE; CHOLANGIOPANCREATOGRAPHY; PROSTHESIS; CHOLANGITIS AB Three recent reports have described external placement of biliary drains for common bile duct (CBD) strictures in children. We report combining endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic cholangiography (PTC), and transductal stenting for the precise diagnosis and management of a complicated CBD stricture. A 5 1/2-year-old boy diagnosed with hepatic rhabdomyosarcoma was treated with induction chemotherapy and extended left hepatic resection. Postoperative neutrophil dysfunction contributed to multiple septic complications requiring three operative procedures for drainage. During these septic episodes cholangitis occurred with a peak serum bilirubin level of 30 mg/dl that finally stabilized at 20 mg/dl. The patient could not be cleared of biliary sepsis. PTC was performed with simultaneous ERCP. A well-defined, discrete CBD stricture was delineated and an external biliary drain was placed. Three weeks later, after the sepsis had cleared and the bilirubin level had markedly decreased, a transhepatic intraductal stent was placed exiting in the duodenum. This was later internalized and remained in place. The patient died 6 months later from a massive pelvic recurrence of his tumor. He suffered no further biliary complications and maintained normal bilirubin levels until his death. We conclude that modalities well-documented in adults for nonoperative management of biliary strictures (PTC, ERCP, stents) can be used successfully in the pediatric population in selected cases. C1 WALTER REED ARMY MED CTR,PEDIAT SURG SERV,WASHINGTON,DC 20307. NR 0 TC 3 Z9 3 U1 0 U2 2 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0179-0358 J9 PEDIATR SURG INT JI Pediatr. Surg. Int. PD MAY PY 1992 VL 7 IS 3 BP 211 EP 213 PG 3 WC Pediatrics; Surgery SC Pediatrics; Surgery GA HQ040 UT WOS:A1992HQ04000015 ER PT J AU HUHMAN, KL MOORE, TO MOUGEY, EH MEYERHOFF, JL AF HUHMAN, KL MOORE, TO MOUGEY, EH MEYERHOFF, JL TI HORMONAL RESPONSES TO FIGHTING IN HAMSTERS - SEPARATION OF PHYSICAL AND PSYCHOLOGICAL CAUSES SO PHYSIOLOGY & BEHAVIOR LA English DT Note DE AGGRESSION; DEFEAT; ADRENOCORTICOTROPIN; BETA-ENDORPHIN; CORTISOL; STRESS; AGONISTIC BEHAVIOR; PROOPIOMELANOCORTIN ID MESOCRICETUS-AURATUS WATERHOUSE; POMC-DERIVED PEPTIDES; GOLDEN-HAMSTERS; BETA-ENDORPHIN; BEHAVIOR; RADIOIMMUNOASSAY; PROLACTIN; PLASMA AB Male Syrian hamsters were paired and allowed to interact with a conspecific for 15 min a day for 4 days. On the fifth day, the animals were again paired, but they were kept physically separated by a mesh partition that allowed visual, olfactory, and auditory contact between the animals. Controls were placed with conspecifics on each of the 5 testing days, but the partition between them was never removed. Hamsters that were submissive on days 1-4 exhibited elevated plasma adrenocorticotropin-like immunoreactivity (ACTH-LI), beta-endorphin-like immunoreactivity (B-EP-LI), and cortisol on day 5 even though no fighting occurred on that day. Dominant hamsters did not differ from controls. These data support the hypothesis that there is an important psychological component to the pituitary-adrenocortical response in defeated hamsters. C1 WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. NR 15 TC 54 Z9 54 U1 2 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD MAY PY 1992 VL 51 IS 5 BP 1083 EP 1086 DI 10.1016/0031-9384(92)90097-L PG 4 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA HY285 UT WOS:A1992HY28500031 PM 1319587 ER PT J AU DON, RC GILLESPIE, JW LAMBING, CLT AF DON, RC GILLESPIE, JW LAMBING, CLT TI EXPERIMENTAL CHARACTERIZATION OF PROCESSING-PERFORMANCE RELATIONSHIPS OF RESISTANCE WELDED GRAPHITE POLYETHERETHERKETONE COMPOSITE JOINTS SO POLYMER ENGINEERING AND SCIENCE LA English DT Article ID THERMOPLASTIC COMPOSITES AB A study to investigate fusion bonding (welding) of AS4 graphite/polyetheretherketone (PEEK) thermoplastic composites is presented. Processing studies are conducted for resistance welding preconsolidated AS4/PEEK laminates in both unidirectional and quasi-isotropic configurations using PEEK and polyetherimide (PEI) film at the joint interface. All bonding was done under a constant displacement process. The influence of processing time, initially applied consolidation pressure, and the rate of heat generation on weld performance is examined through lap shear and Mode I interlaminar fracture toughness testing. A rapid increase in strength with processing time that asymptotically approaches the compression molded baseline is measured. Weld times for quasi-isotropic lap shear coupons are significantly shorter than those with a unidirectional lay-up. Variation of the initially applied consolidation pressure is shown to have little influence on the lap shear strength of PEEK film welded lap joints. A discussion of the mechanisms allowing void formation during the welding process is given. Bond strength test results are correlated with ultrasonic C-scans of the weld regions. C1 USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005. ALCOA,ALCOA LABS,ALCOA CTR,PA 15069. NR 16 TC 16 Z9 17 U1 1 U2 5 PU SOC PLASTICS ENG INC PI BROOKFIELD CENTER PA 14 FAIRFIELD DR, BROOKFIELD CENTER, CT 06804-0403 SN 0032-3888 J9 POLYM ENG SCI JI Polym. Eng. Sci. PD MAY PY 1992 VL 32 IS 9 BP 620 EP 631 DI 10.1002/pen.760320908 PG 12 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA HU948 UT WOS:A1992HU94800007 ER PT J AU DUNN, LTCD AF DUNN, LTCD TI 250-DOLLAR FOR A LIFE SO POSTGRADUATE MEDICINE LA English DT Editorial Material C1 BIGGS GRIDLEY MEM HOSP,GRIDLEY,CA. RP DUNN, LTCD (reprint author), USA,RESERVE MED CORPS,10131 BILICH PL,CUPERTINO,CA 95014, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD MAY 1 PY 1992 VL 91 IS 6 BP 69 EP 70 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA HV264 UT WOS:A1992HV26400004 ER PT J AU SACCI, JB SCHRIEFER, ME RESAU, JH WIRTZ, RA DETOLLA, LJ MARKHAM, RB AZAD, AF AF SACCI, JB SCHRIEFER, ME RESAU, JH WIRTZ, RA DETOLLA, LJ MARKHAM, RB AZAD, AF TI MOUSE MODEL FOR EXOERYTHROCYTIC STAGES OF PLASMODIUM-FALCIPARUM MALARIA PARASITE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID MONOCLONAL-ANTIBODY CHARACTERIZATION; LIVER; HEPATOCYTES; SPOROZOITES; SCHIZONTS; ANTIGENS; CULTURE; INVITRO AB Research on the exoerythrocytic (EE) stages of human malaria parasites has been hindered because of the lack of an easily available suitable animal model. We report here an approach to produce mature EE-stage Plasmodium falciparum parasites by using severe combined immunodeficient (scid) mice with transplanted human hepatocytes. Transplantation of human hepatocytes into scid mice (scid hu-hep), their subsequent intravenous infection with P. falciparum sporozoites, and the development of mature liver-stage merozoites was achieved. Immunofluorescent staining of scid hu-hep kidney tissue sections demonstrated the presence of circum-sporozoite protein (early during infection), merozoite surface antigen 1, and liver schizont antigen 1. The scid hu-hep model can serve as a source of human malaria liver-stage parasites, decreasing the need for nonhuman primates. Use of this model will facilitate characterization of EE-stage antigens and the assessment of stage-specific chemotherapeutic agents and candidate vaccines. C1 UNIV MARYLAND,SCH MED,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,BALTIMORE,MD 21205. FU NIAID NIH HHS [AI-17828, AI-28748, AI-29163] NR 27 TC 25 Z9 25 U1 0 U2 2 PU NATL ACAD PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAY 1 PY 1992 VL 89 IS 9 BP 3701 EP 3705 DI 10.1073/pnas.89.9.3701 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA HR853 UT WOS:A1992HR85300007 PM 1570289 ER PT J AU BALKIN, TJ ODONNELL, VM WESENSTEN, N MCCANN, U BELENKY, G AF BALKIN, TJ ODONNELL, VM WESENSTEN, N MCCANN, U BELENKY, G TI COMPARISON OF THE DAYTIME SLEEP AND PERFORMANCE EFFECTS OF ZOLPIDEM VERSUS TRIAZOLAM SO PSYCHOPHARMACOLOGY LA English DT Article DE ZOLPIDEM; TRIAZOLAM; COGNITIVE PERFORMANCE; SLEEP; MEMORY AB Fifty healthy male subjects were administered zolpidem (5, 10, or 20 mg), triazolam (0.5 mg) or placebo, then attempted to sleep in a non-sleep-conducive environment. Subjects were awakened at 90 min post-drug (near peak blood concentration for both drugs) and tested on several cognitive tasks, including Two Column Addition, Logical Reasoning, and a Simulated Escape Task. This was followed by a second, 3.5-h sleep period. Hypnotic efficacy of the 20 mg zolpidem (Z-20) dose was similar to that of the 0.5 mg triazolam (TRIAZ) dose, as indicated by comparably shortened sleep latencies and lengthened total sleep times. Though accuracy on most performance measures was not affected by either drug, a reduction in speed of responding on logical reasoning and addition tasks was evident for the TRIAZ group at 90 min post-drug (Ps < 0.05). On the simulated escape task, only triazolam significantly increased the mean number of errors, and interfered with subsequent memory of the task. Thus, zolpidem had milder effects on performance than triazolam. However, 60% of the Z-20 subjects experienced mild, adverse physical reactions. Performance differences between somnogenically comparable doses of zolpidem and triazolam may be due to their differential affinities for the BZ1 and BZ2 receptor subtypes. RP BALKIN, TJ (reprint author), WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,HUMAN PSYCHOPHARMACOL BRANCH,WASHINGTON,DC 20307, USA. NR 19 TC 57 Z9 57 U1 1 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0033-3158 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PD MAY PY 1992 VL 107 IS 1 BP 83 EP 88 DI 10.1007/BF02244970 PG 6 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA HK561 UT WOS:A1992HK56100013 PM 1589566 ER PT J AU NIKLASSON, B JONSSON, M WIDEGREN, I PERSSON, K LEDUC, J AF NIKLASSON, B JONSSON, M WIDEGREN, I PERSSON, K LEDUC, J TI A STUDY OF NEPHROPATHIA-EPIDEMICA AMONG MILITARY PERSONNEL IN SWEDEN SO RESEARCH IN VIROLOGY LA English DT Article DE PUUMULA VIRUS, NEPHROPATHIA EPIDEMICA, HFRS; SWEDEN, SOLDIERS AB The incidence of nephropathia epidemica (NE), caused by Puumala virus, among military troops operating in an endemic area of Sweden was investigated. A total of 705 soldiers (age 18-25) involved in field training in three different endemic counties were bled twice within a 6-month interval. Three individuals seroconverted when tested for Puumala virus antibodies by IgG ELISA. Symptoms typical of NE were not recorded in any of the patients. However, mild febrile episodes were recorded in 2 of the 3 individuals. One serologically confirmed soldier with typical NE symptoms was found in another group of 12,000 troops. This soldier fell ill 3 weeks after a 7-day-long field exercise. The present study indicates that military populations are at considerably greater risk of contracting NE when compared to the entire population residing in the same area. C1 SWEDISH DEF RES ESTAB, S-17290 SUNDBYBERG, SWEDEN. MILO NN, S-83125 OSTERSUND, SWEDEN. USA, MED RES INST INFECT DIS, DIV DIS ASSESSMENT, FREDERICK, MD 21702 USA. RP NIKLASSON, B (reprint author), NATL BACTERIOL LAB, DEPT VIROL, S-10521 STOCKHOLM, SWEDEN. NR 10 TC 5 Z9 7 U1 0 U2 0 PU EDITIONS SCIENTIFIQUES ELSEVIER PI PARIS CEDEX 15 PA 141 RUE JAVEL, 75747 PARIS CEDEX 15, FRANCE SN 0923-2516 J9 RES VIROLOGY JI Res. Virol. PD MAY-JUN PY 1992 VL 143 IS 3 BP 211 EP 214 DI 10.1016/S0923-2516(06)80106-8 PG 4 WC Virology SC Virology GA JC565 UT WOS:A1992JC56500007 PM 1355610 ER PT J AU KOSS, M TRAVIS, W MORAN, C HOCHHOLZER, L AF KOSS, M TRAVIS, W MORAN, C HOCHHOLZER, L TI PSEUDOMESOTHELIOMATOUS ADENOCARCINOMA - A REAPPRAISAL SO SEMINARS IN DIAGNOSTIC PATHOLOGY LA English DT Article DE MESOTHELIOMA; ADENOCARCINOMA OF LUNG; BRONCHIOLOALVEOLAR CARCINOMA; ASBESTOS-RELATED LUNG DISEASE RP KOSS, M (reprint author), USA,INST PATHOL,DIV EDITORIAL,ROOM 4018,WASHINGTON,DC 20306, USA. NR 0 TC 38 Z9 38 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0740-2570 J9 SEMIN DIAGN PATHOL JI Semin. Diagn. Pathol. PD MAY PY 1992 VL 9 IS 2 BP 117 EP 123 PG 7 WC Medical Laboratory Technology; Pathology SC Medical Laboratory Technology; Pathology GA JA076 UT WOS:A1992JA07600005 PM 1609154 ER PT J AU MORAN, CA SUSTER, S KOSS, MN AF MORAN, CA SUSTER, S KOSS, MN TI THE SPECTRUM OF HISTOLOGIC GROWTH-PATTERNS IN BENIGN AND MALIGNANT FIBROUS TUMORS OF THE PLEURA SO SEMINARS IN DIAGNOSTIC PATHOLOGY LA English DT Article DE SOLITARY FIBROUS TUMOR; FIBROUS MESOTHELIOMA; SUBMESOTHELIAL FIBROMA; FIBROSARCOMA OF THE PLEURA RP MORAN, CA (reprint author), USA,INST PATHOL,DEPT PULM & MEDIASTINAL PATHOL,WASHINGTON,DC 20306, USA. NR 0 TC 171 Z9 176 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0740-2570 J9 SEMIN DIAGN PATHOL JI Semin. Diagn. Pathol. PD MAY PY 1992 VL 9 IS 2 BP 169 EP 180 PG 12 WC Medical Laboratory Technology; Pathology SC Medical Laboratory Technology; Pathology GA JA076 UT WOS:A1992JA07600010 PM 1609159 ER PT J AU FISTEL, SH RUEDAPEDRAZA, E ISHAK, KG GOODMAN, ZD AF FISTEL, SH RUEDAPEDRAZA, E ISHAK, KG GOODMAN, ZD TI A 29-YEAR-OLD MAN WITH THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME AND LIVER DYSFUNCTION SO SEMINARS IN LIVER DISEASE LA English DT Review ID PNEUMOCYSTIS-CARINII INFECTION; VIRUS-INFECTION; SYNDROME AIDS; HEPATITIS; DISEASE C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. USAF,INST PATHOL,DEPT HEPAT & GASTROINTESTINAL PATHOL,WASHINGTON,DC 20306. USAF,INST PATHOL,VET ADM,SPECIAL REFERENCE LAB PATHOL,WASHINGTON,DC 20306. NR 25 TC 0 Z9 0 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 381 PARK AVE SOUTH, NEW YORK, NY 10016 SN 0272-8087 J9 SEMIN LIVER DIS JI Semin. Liver Dis. PD MAY PY 1992 VL 12 IS 2 BP 219 EP 225 DI 10.1055/s-2007-1007394 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JE346 UT WOS:A1992JE34600014 PM 1636124 ER PT J AU AZAROW, KS MOLLOY, M KAVOLIUS, J SAYLES, J CABELLON, S PEARL, RH AF AZAROW, KS MOLLOY, M KAVOLIUS, J SAYLES, J CABELLON, S PEARL, RH TI PERIOPERATIVE COMPLICATIONS OF LONG-TERM CENTRAL VENOUS CATHETERS IN HIGH-RISK PATIENTS - PREDICTORS VERSUS MYTHS SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID HICKMAN-BROVIAC CATHETERS; RIGHT-ATRIAL CATHETER; ACCESS; PLACEMENT; INSERTION; BACTEREMIA AB A prospective cohort of 126 patients having long-term central venous catheterization was collected over a 10-month period. The patients were preoperatively assessed for the following risk factors: previous catheter placement, an absolute neutrophil count less than 500/mm3, a platelet count less than 50000/mm3, a BUN value greater than 60 mg/dL or a serum creatinine level greater than 2.5 mg/dL, a prothrombin time greater than 1.5 times control, recent sepsis, and a Western blot test positive for HIV. The incidence of perioperative complications was 23%. Complications included pneumothorax, arterial puncture, tunnel hematoma, unsuccessful initial placement, and reaction to local anesthesia or blood products. No single risk factor had any statistical significance in predicting a complication. In the subpopulation of patients having two or more risk factors, the complication rate was 50%, with the majority of these being failed placement attempts. We conclude that inserting a permanent central venous catheter is not a benign procedure, but it can be safely done in critically ill patients. Furthermore, evaluation of preoperative risk factors in candidates for catheterization can be helpful to the surgeon with respect to counseling and operative planning. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP AZAROW, KS (reprint author), WALTER REED ARMY MED CTR,DEPT GEN SURG,WASHINGTON,DC 20307, USA. NR 20 TC 5 Z9 5 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD MAY PY 1992 VL 85 IS 5 BP 498 EP 501 DI 10.1097/00007611-199205000-00009 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA HV017 UT WOS:A1992HV01700009 PM 1585202 ER PT J AU POROPATICH, MR PHILLIPS, YY AF POROPATICH, MR PHILLIPS, YY TI LISTERIAL BRAIN-ABSCESS IN LONG-STANDING SARCOIDOSIS SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID CENTRAL NERVOUS-SYSTEM; MONOCYTOGENES; MANIFESTATIONS; OUTBREAK RP POROPATICH, MR (reprint author), WALTER REED ARMY MED CTR, DEPT MED, WASHINGTON, DC 20307 USA. NR 18 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD MAY PY 1992 VL 85 IS 5 BP 554 EP 556 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA HV017 UT WOS:A1992HV01700020 ER PT J AU MELANSON, GF OTCHY, DP WALTERS, MJ MADSEN, J AF MELANSON, GF OTCHY, DP WALTERS, MJ MADSEN, J TI THE IMPORTANCE OF STABILIZING THE SPECIMEN TAKEN AT NEEDLE LOCALIZED BIOPSY OF THE BREAST FOR MICROCALCIFICATIONS SO SURGERY GYNECOLOGY & OBSTETRICS LA English DT Article ID NONPALPABLE LESIONS; CANCER; MAMMOGRAPHY; MANAGEMENT; DIAGNOSIS; CARCINOMA AB The specimen from a needle localized biopsy of the breast must be compared with its roentgenogram to locate the area of microcalcification within the specimen. Any errors in aligning the specimen to its roentgenogram could result in failure to sample and microscopically examine the area of the microcalcifications. The results of the current study show the importance of maintaining the orientation and position of the specimen from the time the roentgenogram is taken until it is examined by the pathologist. Each of 45 consecutive specimens taken at biopsy were secured to a square of cardboard immediately after excision from the breast to maintain the orientation of the specimen during the process of roentgenography. The histologic findings of this group (group 2) were compared with the preceding 87 biopsies (group 1) in which no effort had been made to immobilize the specimen for a roentgenogram. The presence of microcalcifications was confirmed roentgenographically in all the specimens of each group. Histologic confirmation of the presence of microcalcifications was obtained in 42 of 45 specimens in group 2 and only 71 of 87 in group 1 (p = 0.035). Thirty-one per cent of specimens in group 2 contained a carcinoma compared with 10 per cent in group 1. We conclude that fixing the position of the specimen after excision improves the ability of the pathologist to locate the suspicious area of microcalcifications within the specimen. This may lead to an increase in the yield of these biopsies and the identification of occult carcinomas that might otherwise be missed. C1 BROOKE ARMY MED CTR,DEPT SURG & PATHOL,GEN SURG SERV,FT SAM HOUSTON,TX 78234. NR 12 TC 3 Z9 3 U1 0 U2 0 PU FRANKLIN H MARTIN FOUNDATION PI CHICAGO PA 55 E ERIE ST, CHICAGO, IL 60611 SN 0039-6087 J9 SURG GYNECOL OBSTET JI Surg. Gynecol. Obstet. PD MAY PY 1992 VL 174 IS 5 BP 376 EP 378 PG 3 WC Obstetrics & Gynecology; Surgery SC Obstetrics & Gynecology; Surgery GA HU069 UT WOS:A1992HU06900006 PM 1570614 ER PT J AU VANGEL, MG AF VANGEL, MG TI NEW METHODS FOR ONE-SIDED TOLERANCE LIMITS FOR A ONE-WAY BALANCED RANDOM-EFFECTS ANOVA MODEL SO TECHNOMETRICS LA English DT Article DE BEHRENS-FISHER PROBLEM; DESIGN ALLOWABLE; NUISANCE PARAMETER AB The problem of determining one-sided tolerance limits or, equivalently, one-sided confidence limits on a quantile of a normal population with variance-sigma-2 = sigma(b)2 + sigma(e)2 is considered in this article. The tolerance limits are obtained using data from a one-way balanced random-effects sample from this population. Two procedures are introduced-a simple approximate method based on an asymptotic expansion and a computer-intensive procedure that provides very nearly the nominal confidence in the presence of the nuisance variance-component ratio. For the computer-intensive procedure, tables are provided that eliminate the need for most of the computation for some important situations. Tolerance limits for strength are routinely used in structural design. Material strength, particularly for composite materials, often exhibits considerable between-batch variability. A tolerance limit that provides nearly the nominal confidence is usually preferable to a conservative limit, since a conservative tolerance limit underestimates the capability of the material. An aircraft-industry application to determining tolerance limits for composite material properties in the presence of between-batch variability is discussed. RP VANGEL, MG (reprint author), USA,MAT TECHNOL LAB,SLCMT-MRS,WATERTOWN,MA 02172, USA. NR 15 TC 30 Z9 30 U1 0 U2 3 PU AMER STATISTICAL ASSOC PI ALEXANDRIA PA 1429 DUKE ST, ALEXANDRIA, VA 22314 SN 0040-1706 J9 TECHNOMETRICS JI Technometrics PD MAY PY 1992 VL 34 IS 2 BP 176 EP 185 DI 10.2307/1269233 PG 10 WC Statistics & Probability SC Mathematics GA HQ464 UT WOS:A1992HQ46400003 ER PT J AU SHANKS, GD WATT, G EDSTEIN, MD WEBSTER, HK LOESUTTIVIBOON, L WECHGRITAYA, S AF SHANKS, GD WATT, G EDSTEIN, MD WEBSTER, HK LOESUTTIVIBOON, L WECHGRITAYA, S TI HALOFANTRINE GIVEN WITH FOOD FOR FALCIPARUM-MALARIA SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Note C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RI Shanks, George Dennis/F-4056-2014 OI Shanks, George Dennis/0000-0001-5763-8660 NR 4 TC 24 Z9 24 U1 0 U2 0 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD MAY-JUN PY 1992 VL 86 IS 3 BP 233 EP 234 DI 10.1016/0035-9203(92)90286-L PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JD304 UT WOS:A1992JD30400005 PM 1412639 ER PT J AU CONSTANTINE, NT SCOTT, DA KAMAL, M ROBERTS, CR ROLFS, A SCHUMACHER, HC MARX, P AF CONSTANTINE, NT SCOTT, DA KAMAL, M ROBERTS, CR ROLFS, A SCHUMACHER, HC MARX, P TI TROPICAL SPASTIC PARAPARESIS ASSOCIATED WITH HTLV-1 IN EGYPT SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Note ID VIRUS TYPE-I C1 ABBASSIA FEVER HOSP,CAIRO,EGYPT. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. FREE UNIV BERLIN,W-1000 BERLIN 33,GERMANY. RP CONSTANTINE, NT (reprint author), USN,MED RES UNIT 3,CAIRO,EGYPT. NR 11 TC 5 Z9 5 U1 0 U2 0 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD MAY-JUN PY 1992 VL 86 IS 3 BP 300 EP 301 DI 10.1016/0035-9203(92)90320-C PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JD304 UT WOS:A1992JD30400029 PM 1412661 ER PT J AU SANCHEZ, JL CANDLER, WH FISHBEIN, DB GREENE, CR COTE, TR KELLY, DJ DRIGGERS, DP JOHNSON, BJB AF SANCHEZ, JL CANDLER, WH FISHBEIN, DB GREENE, CR COTE, TR KELLY, DJ DRIGGERS, DP JOHNSON, BJB TI A CLUSTER OF TICK-BORNE INFECTIONS - ASSOCIATION WITH MILITARY TRAINING AND ASYMPTOMATIC INFECTIONS DUE TO RICKETTSIA-RICKETTSII SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LINKED IMMUNOSORBENT-ASSAY; LYME-DISEASE; EHRLICHIOSIS AB During the spring of 1989, 86 members of a military unit from the state of Maryland, USA, participated in two-week-long training manoeuvres in the states of Arkansas (location FC) and Virginia (location FAPD). Acute febrile illnesses due to infections with two tick-borne pathogens, Rickettsia rickettsii and Ehrlichia sp., were confirmed serologically in 2 initial cases who were admitted to the hospital. A seroepidemiological investigation among unit members found an additional 17 of 109 individuals (16%) with elevated post-exposure indirect immunofluorescent antibody (IFA) titres to R. rickettsii (16 cases) and/or E. canis (2 cases). The seropositivity rate of personnel who trained at FC was 38% (15 of 40), compared to only 13% (4 of 31) and 8% (3 of 38) of personnel who trained at FAPH or who did not train in the field, respectively (P<0.001). Seropositivity was associated with symptoms suggestive of a tick-borne illness. Only 4 (22%) and 6 (33%) of the 18 personnel seropositive for R. rickettsii reported an erythematous or petechial type of rash or a febrile illness, respectively, within 4 weeks of exposure; 5 of 18 (28%) personnel infected with R. rickettsii reported no symptoms and only 8 of 18 (44%) received medical treatment. Mild infections with R. rickettsii, or a closely related spotted fever group agent, may have accounted for the high infection rate experienced by this group. C1 MARYLAND STATE HLTH DEPT,EPIDEMIOL & DIS CONTROL PROGRAM,BALTIMORE,MD 21201. USN,MED RES INST,RICKETTSIAL DIS PROGRAM,BETHESDA,MD 20889. OFF ARMY SURGEON GEN,FALLS CHURCH,VA 22041. CTR DIS CONTROL,DIV VECTOR BORNE INFECT DIS,FT COLLINS,CO 80522. CTR DIS CONTROL,DIV VIRAL & RICKETTSIAL DIS,ATLANTA,GA 30333. RP SANCHEZ, JL (reprint author), WALTER REED ARMY MED CTR,DIV PREVENT MED,DEPT FIELD STUDIES,WASHINGTON,DC 20307, USA. NR 21 TC 36 Z9 37 U1 2 U2 2 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD MAY-JUN PY 1992 VL 86 IS 3 BP 321 EP 325 DI 10.1016/0035-9203(92)90330-F PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JD304 UT WOS:A1992JD30400036 PM 1412666 ER PT J AU SARNO, AP ROSE, GS HARRINGTON, RA AF SARNO, AP ROSE, GS HARRINGTON, RA TI CORONAL TRANSCEREBELLAR DIAMETER - AN ALTERNATE VIEW SO ULTRASOUND IN OBSTETRICS & GYNECOLOGY LA English DT Article DE FETAL CEREBELLUM; AXIAL AND CORONAL TRANSCEREBELLAR DIAMETER AB Evaluation of the fetal cerebellum in the axial plane has become an important part of obstetric sonography. We report our experience with an alternate view, the coronal transcerebellar view, in 134 fetuses at gestational ages of 13-30 weeks. There is a linear first-order correlation between axial and coronal transcerebellar diameters. Additionally, the coronal view was more reliably obtained, especially at gestational ages between 24 and 30 weeks. We believe that this view warrants further study, particularly in pathological states. RP SARNO, AP (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,CTR ANTEPARTUM DIAGNOST,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PARTHENON PUBLISHING GROUP PI CARNFORTH LANCASHIRE PA CASTERTON HALL, CARNFORTH LANCASHIRE, ENGLAND LA6 2LA SN 0960-7692 J9 ULTRASOUND OBST GYN JI Ultrasound Obstet. Gynecol. PD MAY PY 1992 VL 2 IS 3 BP 158 EP 161 DI 10.1046/j.1469-0705.1992.02030158.x PG 4 WC Acoustics; Obstetrics & Gynecology; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Obstetrics & Gynecology; Radiology, Nuclear Medicine & Medical Imaging GA JQ341 UT WOS:A1992JQ34100005 PM 12796966 ER PT J AU ZEIDMAN, EJ DESMOND, P THOMPSON, IM AF ZEIDMAN, EJ DESMOND, P THOMPSON, IM TI SURGICAL-TREATMENT OF CARCINOMA OF THE MALE URETHRA SO UROLOGIC CLINICS OF NORTH AMERICA LA English DT Article ID SQUAMOUS-CELL CARCINOMA; PENIS C1 BROOKE ARMY MED CTR,DEPT SURG,UROL SERV,FT SAM HOUSTON,TX 78234. NR 27 TC 31 Z9 32 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0094-0143 J9 UROL CLIN N AM JI Urol. Clin. N. Am. PD MAY PY 1992 VL 19 IS 2 BP 359 EP 372 PG 14 WC Urology & Nephrology SC Urology & Nephrology GA LA255 UT WOS:A1992LA25500017 PM 1574826 ER PT J AU LIOU, CP FERRICK, MG AF LIOU, CP FERRICK, MG TI A MODEL FOR VERTICAL FRAZIL DISTRIBUTION SO WATER RESOURCES RESEARCH LA English DT Article ID ICE; TURBULENCE; FLOW AB A model is presented for the evolution of frazil over depth and with time in a turbulent flow. The net upward migration due to buoyancy of the frazil is opposed by intermittent mixing induced by large energy-containing eddies. A surface renewal model is used to describe the effects of large eddy mixing. Parameters that represent an entire water body are obtained by averaging those of discrete water columns using a probability density function. These parameters include the concentration profile, the surface age, and the surface layer thickness. A dimensionless surface renewal frequency characterizes the frazil distribution at equilibrium. The rate of heat loss from the water surface, the surface renewal frequency, and the critical surface layer thickness determine whether the frazil will evolve toward a well-mixed equilibrium state or a layered state. The model provides a physical basis for understanding the transition between these states. consistent with existing empirical criteria and field data. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP LIOU, CP (reprint author), UNIV IDAHO,DEPT CIVIL ENGN,MOSCOW,ID 83843, USA. NR 31 TC 2 Z9 2 U1 1 U2 1 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD MAY PY 1992 VL 28 IS 5 BP 1329 EP 1337 DI 10.1029/92WR00058 PG 9 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA HT438 UT WOS:A1992HT43800013 ER PT J AU MCDONNELL, JA AF MCDONNELL, JA TI AMERICAN-INDIANS AND WORLD-WAR-2 - TOWARD A NEW ERA IN INDIAN AFFAIRS - BERNSTEIN,AR SO WESTERN HISTORICAL QUARTERLY LA English DT Book Review RP MCDONNELL, JA (reprint author), USA CORPS ENGINEERS,SEATTLE,WA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WESTERN HISTORY ASSOCIATION PI LOGAN PA UTAH STATE UNIV, UMC 0740, LOGAN, UT 84322 SN 0043-3810 J9 WESTERN HIST QUART JI West. Hist. Q. PD MAY PY 1992 VL 23 IS 2 BP 240 EP 241 DI 10.2307/970461 PG 2 WC History SC History GA HW466 UT WOS:A1992HW46600021 ER PT J AU ASHANI, Y PEGGINS, JO DOCTOR, BP AF ASHANI, Y PEGGINS, JO DOCTOR, BP TI MECHANISM OF INHIBITION OF CHOLINESTERASES BY HUPERZINE-A SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID ACETYLCHOLINESTERASE C1 ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. RP ASHANI, Y (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 11 TC 90 Z9 92 U1 0 U2 4 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD APR 30 PY 1992 VL 184 IS 2 BP 719 EP 726 DI 10.1016/0006-291X(92)90649-6 PG 8 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA HR526 UT WOS:A1992HR52600025 PM 1575745 ER PT J AU SAMUELSON, L MILLER, P GALOTTI, D MARX, KA KUMAR, J TRIPATHY, S KAPLAN, D AF SAMUELSON, L MILLER, P GALOTTI, D MARX, KA KUMAR, J TRIPATHY, S KAPLAN, D TI LANGMUIR-BLODGETT-FILMS OF STREPTAVIDIN-CONJUGATED PHYCOERYTHRIN BOUND TO BIOTINYLATED MONOLAYERS SO THIN SOLID FILMS LA English DT Article; Proceedings Paper CT 5TH INTERNATIONAL CONF ON LANGMUIR-BLODGETT FILMS CY AUG 26-30, 1991 CL PARIS, FRANCE ID PHYCOBILISOMES; BINDING AB The Langmuir-Blodgett technique has been used to simultaneously orient and couple the photodynamic, water soluble protein, phycoerythrin, to a biotin derivatized phospholipid monolayer film. It was found that both avidin and streptavidin phycoerythrin conjugates will preferentially adsorb to the biotinylated lipid monolayer films while at the air-water interface. Pressure-area isotherms indicate that oriented monolayer films are formed with the hydrophilic biotin binding sites exposed to the four biotin binding sites on avidin and streptavidin in the conjugated proteins. The binding of protein to the lipid films was determined by probing the characteristic, intense fluorescence of the phycoerythrin at 576 nm. The measurements were carried out on monolayer films transferred onto solid glass supports, exciting the samples with 496 nm light and scanning the emission from 515 to 670 nm. It was determined that avidin conjugated proteins complex to the biotin lipid monolayer through both specific and non-specific binding mechanisms, while the streptavidin-phycoerythrin binds by what appears to be only a specific (biotin-streptavidin) mechanism. C1 UNIV LOWELL,DEPT CHEM,LOWELL,MA 01854. UNIV LOWELL,DEPT PHYS,LOWELL,MA 01854. RP SAMUELSON, L (reprint author), USA,NATICK LAB,BIOTECHNOL BRANCH,NATICK,MA 01760, USA. NR 11 TC 5 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD APR 30 PY 1992 VL 210 IS 1-2 BP 796 EP 798 DI 10.1016/0040-6090(92)90407-3 PG 3 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA HV025 UT WOS:A1992HV02500108 ER PT J AU ZHU, XT GORONKIN, H MARACAS, GN DROOPAD, R STROSCIO, MA AF ZHU, XT GORONKIN, H MARACAS, GN DROOPAD, R STROSCIO, MA TI ELECTRON-MOBILITY ENHANCEMENT BY CONFINING OPTICAL PHONONS IN GAAS/ALAS MULTIPLE QUANTUM-WELLS SO APPLIED PHYSICS LETTERS LA English DT Article ID DOUBLE HETEROSTRUCTURES; FROHLICH INTERACTION; SCATTERING AB We report experimental evidence for an enhanced electron mobility in a multiple quantum well structure in which the optical phonon modes are confined. By inserting n ultrathin layers of AlAs into a host GaAs well, thus dividing the bulklike host well into n + 1 miniwells, we observe a substantial enhancement in electron mobility for temperatures T > 100 K. We have also studied the dependence of the electron mobility on the miniwell width. The electron mobility is found to first increase with decreasing miniwell width and then decrease after reaching a maximum value at the width around 45 angstrom. C1 ARIZONA STATE UNIV,DEPT ELECT ENGN,TEMPE,AZ 85287. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP ZHU, XT (reprint author), MOTOROLA INC,PHOENIX CORP RES LABS,TEMPE,AZ 85284, USA. NR 12 TC 28 Z9 28 U1 3 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 27 PY 1992 VL 60 IS 17 BP 2141 EP 2143 DI 10.1063/1.107063 PG 3 WC Physics, Applied SC Physics GA HQ500 UT WOS:A1992HQ50000034 ER PT J AU JAYASURIYA, K AF JAYASURIYA, K TI A COMPUTATIONAL INVESTIGATION OF PHOSPHAALKYNES - A NEW BUILDING BLOCK SO THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE LA English DT Article ID PHOSPHORUS-COMPOUNDS; COMPLEXES AB The electronic properties of C = P, C = P and C-P bonds and their aza analogues, C = N, C = N and C-N bonds, were investigated using an ab initio self-consistent field molecular orbital approach at the 4-31G* level. The cyclodimerization and cyclotetramerization of the monomer, methylphosphaacetylene (CH3-C = P) were analyzed by the molecular electrostatic potential (MEP) method. Based on the MEP maps, two reactive sites attractive towards an incoming electrophile were identified for phosphaacetylene, but its aza analogue, acetonitrile, showed only a single reactive site. The -C = P group, in contrast to the -C = N group, tends to form 'side-on' bonds with transition metals, and this has been reinforced by MEP maps of phosphaacetylene, indicating a larger negative region near the pi-bonds. RP JAYASURIYA, K (reprint author), USA,CTR RES DEV & ENGN,GEOCTR CORP,BLDG 3028,PICATINNY,ARSENAL,NJ 07806, USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 THEOCHEM-J MOL STRUC JI Theochem-J. Mol. Struct. PD APR 23 PY 1992 VL 88 BP 17 EP 27 PG 11 WC Chemistry, Physical SC Chemistry GA HT301 UT WOS:A1992HT30100003 ER PT J AU DUTTA, M SHEN, H SMITH, DD CHOI, KK NEWMAN, PG AF DUTTA, M SHEN, H SMITH, DD CHOI, KK NEWMAN, PG TI LOCALIZATION OF ELECTRONS BY ELECTRIC-FIELD IN GAAS/ALAS GAMMA-X COUPLED STRUCTURES SO SURFACE SCIENCE LA English DT Article; Proceedings Paper CT 5TH INTERNATIONAL CONF ON MODULATED SEMICONDUCTOR STRUCTURES ( MSS-5 ) CY JUL 08-12, 1991 CL NARA, JAPAN SP YAMADA SCI FDN ID QUANTUM-WELLS; SUPERLATTICES; SPECTROSCOPY AB We present experimental data in two different types of structures involving GaAs/AlAs multiple quantum wells which demonstrate the coupling between the GAMMA and X confined levels in the GaAs and the AlAs layers. The electrons which are delocalized when the confined level is nearly degenerate with the X-valley can be localized with the application of an electric field. Experiments done in a hot electron transistor structure allow the levels in the AlAs and the coupling of the levels to be observed in the hot electron spectra. C1 GEOCENTERS INC,NEWTON UPPER FALLS,MA 02164. RP DUTTA, M (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 10 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-6028 J9 SURF SCI JI Surf. Sci. PD APR 21 PY 1992 VL 267 IS 1-3 BP 474 EP 478 DI 10.1016/0039-6028(92)91180-J PG 5 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA HM901 UT WOS:A1992HM90100109 ER PT J AU GILLESPIE, JB LINDBERG, JD AF GILLESPIE, JB LINDBERG, JD TI SEASONAL AND GEOGRAPHIC VARIATIONS IN IMAGINARY REFRACTIVE-INDEX OF ATMOSPHERIC PARTICULATE MATTER SO APPLIED OPTICS LA English DT Article AB Samples of atmospheric particulate matter were collected on cellulose membrane filters at selected locations in Europe during 1976 and 1977 as part of an international cooperative atmospheric characterization program. These samples are analyzed for imaginary refractive index in the 0.3-1.7-mu-m spectral region. These data are used to determine the range of variability of the imaginary refractive index and are examined for seasonal variations. These data are discussed in the light of results of analysis of samples collected from other parts of the world and samples that were analyzed as a function of particle size. C1 SCI & TECHNOL CORP,LAS CRUCES,NM 88001. RP GILLESPIE, JB (reprint author), USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 11 TC 9 Z9 10 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD APR 20 PY 1992 VL 31 IS 12 BP 2107 EP 2111 PG 5 WC Optics SC Optics GA HP607 UT WOS:A1992HP60700034 PM 20720865 ER PT J AU GILLESPIE, JB LINDBERG, JD AF GILLESPIE, JB LINDBERG, JD TI ULTRAVIOLET AND VISIBLE IMAGINARY REFRACTIVE-INDEX OF STRONGLY ABSORBING ATMOSPHERIC PARTICULATE MATTER SO APPLIED OPTICS LA English DT Article AB Determinations of the imaginary refractive index in the ultraviolet and visible spectral regions as determined from diffuse reflectance measurements are presented. Materials examined are carbon black and oxides of iron, lead, mercury, copper, manganese, and vanadium along with lead iodide and iron sulfide. C1 SCI & TECHNOL CORP,LAS CRUCES,NM 88001. RP GILLESPIE, JB (reprint author), USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 8 TC 23 Z9 23 U1 1 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD APR 20 PY 1992 VL 31 IS 12 BP 2112 EP 2115 PG 4 WC Optics SC Optics GA HP607 UT WOS:A1992HP60700035 PM 20720866 ER PT J AU ESSIEN, M GILLESPIE, JB ARMSTRONG, RL AF ESSIEN, M GILLESPIE, JB ARMSTRONG, RL TI OBSERVATION OF SUPPRESSION OF MORPHOLOGY-DEPENDENT RESONANCES IN SINGLY LEVITATED MICROMETER-SIZED DROPLETS SO APPLIED OPTICS LA English DT Article ID PARTIAL-WAVE RESONANCES AB Suppression of morphology-dependent resonances of the light elastically scattered by a laser-illuminated, micrometer-sized droplet is reported. A single nonabsorbing droplet is levitated by using an electrodynamic quadrupole trap, and the scattered light is monitored as the droplet slowly evaporates. The size of the droplet is approximated by using the instability characteristics of the electrodynamic trap. To determine the refractive index and droplet radius precisely, the experimental scattering curve is fitted to a scattering curve that is generated from Mie theoretical calculations. The procedure is then repeated for absorbing droplets. The quality factor Q of each experimental resonance is determined and used to quantify the suppression effect. A dramatic suppression of narrow resonances occurs with increased absorption, whereas little or no effect is seen in moderate to broad resonances. C1 USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP ESSIEN, M (reprint author), NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003, USA. NR 14 TC 8 Z9 8 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD APR 20 PY 1992 VL 31 IS 12 BP 2148 EP 2153 PG 6 WC Optics SC Optics GA HP607 UT WOS:A1992HP60700039 PM 20720870 ER PT J AU LLOYD, WC LEONE, CR AF LLOYD, WC LEONE, CR TI SUPERVOLTAGE ORBITAL RADIOTHERAPY IN 36 CASES OF GRAVES-DISEASE SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article ID RADIATION-THERAPY; OPHTHALMOPATHY; ORBITOPATHY; MANAGEMENT AB Thirty-six patients who had clinically progressive Graves' dysthyroid orbitopathy were treated with supervoltage orbital radiotherapy. Twenty-three of the patients had discontinued the use of orally administered prednisone after developing intolerable side effects. Medical contraindications prevented seven patients from receiving systemic corticosteroid treatment. Six additional patients declined to take prednisone and chose orbital radiotherapy as their primary treatment. All patients were treated with one radiotherapy protocol wherein a 6 MV linear accelerator delivered 2,000 cGy to the midplane of both orbits in ten fractions. None of the 36 patients was treated with corticosteroids during the orbital radiotherapy treatment interval. We encountered three patients who failed to respond to orbital radiotherapy and required supplemental immunosuppression to arrest progression of Graves' disease. The remaining 33 patients experienced stabilization or clinical improvement of their condition. None of the patients experienced complications from orbital irradiation. We believe supervoltage orbital radiotherapy is an effective means of treating Graves' dysthyroid orbitopathy. C1 UNIV TEXAS,HLTH SCI CTR,DEPT OPHTHALMOL,MED CTR TOWER,SUITE 505,7950 FLOYD CURL DR,SAN ANTONIO,TX 78229. BROOKE ARMY MED CTR,OPHTHALMOL SERV,FT SAM HOUSTON,TX 78234. NR 16 TC 20 Z9 21 U1 0 U2 0 PU OPHTHALMIC PUBL CO PI CHICAGO PA 77 WEST WACKER DR, STE 660, CHICAGO, IL 60601 SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD APR 15 PY 1992 VL 113 IS 4 BP 374 EP 380 PG 7 WC Ophthalmology SC Ophthalmology GA HM922 UT WOS:A1992HM92200002 PM 1558110 ER PT J AU RUSTAD, JR YUEN, DA SPERA, FJ AF RUSTAD, JR YUEN, DA SPERA, FJ TI COORDINATION VARIABILITY AND THE STRUCTURAL COMPONENTS OF SILICA GLASS UNDER HIGH-PRESSURES SO CHEMICAL GEOLOGY LA English DT Article ID MOLECULAR-DYNAMICS; COMPUTER-SIMULATION; LIQUID SILICATES; MELTING CURVE; CRYSTALLINE; RAMAN; SIO2; GPA; PEROVSKITE; SPECTRA AB The description of the structure of siliceous melts as the silicon ions transform from four- to six-fold coordination with increasing pressure is difficult because their structures range from open networks at low pressures to ones which are more nearly close-packed at pressures of 25-30 GPa. The effect of these coordination modifications on the density, diffusivity, viscosity and melting behavior of silicate liquids is of vital importance to the transport of partial melt in the mantle. Using molecular dynamics calculations, we have investigated the physical and structural characteristics of amorphous silica up to pressures of 1 3 5 GPa. The pairwise potential of S. Tsuneyuki,and coworkers has previously been proven to be remarkably versatile in the simulation of several crystalline silica polymorphs. We point out some problems connected with its parameterization when used for amorphous phases at high pressures or high temperatures. We find large concentrations (30-50%) of five-fold coordinated Si atoms in square pyramidal geometry between 15 and 30 GPa. We describe some alternative interpretations of melt structure involving the Delaunay network and these are consistent with a model of liquid structure involving mixing of four-, five- and six-fold coordinated Si atoms with an associated negative excess mixing volume coupled with an ideal entropy of mixing on the order of 1-1.75 R. Neighbor cage backscattering effects are largely controlled by physical neighbor distances (those within the first radial distribution function coordination shell) and are not sensitive to the volume reduction of the surrounding Voronoi cell, but their behavior at long times may be controlled by the decreased Voronoi cell anisotropy at higher pressures. C1 UNIV MINNESOTA, DEPT GEOL & GEOPHYS, MINNEAPOLIS, MN 55455 USA. UNIV CALIF SANTA BARBARA, DEPT GEOL SCI, SANTA BARBARA, CA 93106 USA. UNIV CALIF SANTA BARBARA, INST CRUSTAL STUDIES, SANTA BARBARA, CA 93106 USA. RP USA, HIGH PERFORMANCE COMP RES CTR, MINNESOTA SUPERCOMP INST, MINNEAPOLIS, MN 55415 USA. NR 58 TC 15 Z9 15 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2541 EI 1878-5999 J9 CHEM GEOL JI Chem. Geol. PD APR 15 PY 1992 VL 96 IS 3-4 BP 421 EP 437 DI 10.1016/0009-2541(92)90070-L PG 17 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA HU748 UT WOS:A1992HU74800015 ER PT J AU CHEUNG, KS HARRISON, RJ YIP, S AF CHEUNG, KS HARRISON, RJ YIP, S TI STRESS-INDUCED MARTENSITIC TRANSITION IN A MOLECULAR-DYNAMICS MODEL OF ALPHA-IRON SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID MONTE-CARLO SIMULATION; UNIVERSAL FEATURES; METALS; TEMPERATURE; SYSTEMS AB A structural transition bcc --> hcp induced by uniaxial tensile stress is observed by molecular dynamics simulation using an interatomic potential function for alpha-iron derived by the embedded atom method. The transformation is reversible with hysteresis. The deformation mechanism for the forward transition is found to be different from that for the backward transition. The critical stress required for the transition decreases with increasing temperature, as is expected. C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP CHEUNG, KS (reprint author), MIT,DEPT NUCL ENGN,CAMBRIDGE,MA 02139, USA. NR 33 TC 22 Z9 22 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 15 PY 1992 VL 71 IS 8 BP 4009 EP 4014 DI 10.1063/1.350846 PG 6 WC Physics, Applied SC Physics GA HP366 UT WOS:A1992HP36600053 ER PT J AU KRZYCH, U JAREED, T LINK, HT LOOMIS, LD BALLOU, WR AF KRZYCH, U JAREED, T LINK, HT LOOMIS, LD BALLOU, WR TI DISTINCT T-CELL SPECIFICITIES ARE INDUCED WITH THE AUTHENTIC VERSUS RECOMBINANT PLASMODIUM-BERGHEI CIRCUMSPOROZOITE PROTEIN SO JOURNAL OF IMMUNOLOGY LA English DT Article ID ANTIGEN-PRESENTING FUNCTION; FALCIPARUM-MALARIA; BETA-GALACTOSIDASE; SUPPRESSOR CELLS; IMMUNE-RESPONSE; EPITOPES; CLONES; IMMUNIZATION; DETERMINANTS; ANTIBODIES AB Plasmodium berghei sporozoite (SPZ)-immune lymph node (LN) cells obtained from mice of different H-2 haplotypes were analyzed for the presence of circumsporozoite (CS) protein-reactive T cells in proliferative assays. Although lymphocytes from each strain responded in vitro to the priming Ag and to the soluble rCS protein, they did not respond to CS protein synthetic peptides. Parallel analysis of rCS protein-primed LN cells revealed that the two Ag are unequal in generating T cell specificities: although SPZ priming did not induce CS protein peptide-reactive T cells, priming with rCS protein did. Not being privy to the processing and presentation of SPZ Ag, we postulated that a different order of processing of the authentic, i.e., SPZ-associated CS protein vs soluble rCS protein might be responsible for the generation of different T cell specificities. Accordingly, authentic CS protein might not be processed by APC, or the processed fragments might obscure the recognition of smaller peptide fragments. Therefore, we subjected the SPZ to three cycles of a freeze/thaw procedure and used the denatured SPZ preparation for priming. We observed that contrary to priming with the authentic SPZ, denatured SPZ generated T cells reactive to some of the CS protein synthetic peptides. The hypothesis that each form of the SPZ Ag is subject to a unique Ag processing was also confirmed in experiments demonstrating a lack of recognition of the authentic CS protein by rCS protein-primed LN cells. Hence, the evidence presented in this work that complex protozoan Ag, such as Plasmodia, might present different requirements for Ag-specific T cell induction/activation not only enhances the basic understanding of the immune system, but is essential for the development of antimalaria vaccine(s). In addition, these observations support the hypothesis that the molecular context of the priming Ag influences the outcome of T cell specificities, by providing evidence that the authentic CS protein induces a T cell repertoire that is distinct from that induced by the rCS protein. C1 CATHOLIC UNIV AMER,DEPT BIOL,WASHINGTON,DC 20064. RP KRZYCH, U (reprint author), WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307, USA. NR 31 TC 14 Z9 14 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 15 PY 1992 VL 148 IS 8 BP 2530 EP 2538 PG 9 WC Immunology SC Immunology GA HN740 UT WOS:A1992HN74000032 PM 1348519 ER PT J AU TURPIN, JA VARGO, M MELTZER, MS AF TURPIN, JA VARGO, M MELTZER, MS TI ENHANCED HIV-1 REPLICATION IN RETINOID-TREATED MONOCYTES - RETINOID EFFECTS MEDIATED THROUGH MECHANISMS RELATED TO CELL-DIFFERENTIATION AND TO A DIRECT TRANSCRIPTIONAL ACTION ON VIRAL GENE-EXPRESSION SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; NECROSIS-FACTOR-ALPHA; LEUKEMIA THP-1 CELLS; LONG TERMINAL REPEAT; BLOOD MONOCYTES; AIDS PATIENTS; BRAIN-TISSUE; VITAMIN-A; INFECTION; ACID AB Vitamin A and other retinoids have profound effects on macrophage differentiation and function. Such effects could alter interactions between HIV and tissue macrophages, a principal target cell and reservoir for virus during HIV disease. Indeed, retinoids are used to treat various symptoms associated with HIV infection. We show that levels of virus replication in monocytes cultured 7 days before and continuously after HIV infection in 1 to 10-mu-M retinoic acid were 10- to 20-fold greater than those of control cells. No direct toxicity (detachment from substrate or cell death) was evident in infected or control monocytes treated with less-than-or-equal-to 10-mu-M retinoic acid. Maximum effects of retinoic acid (50% maximum effect was at 0.8 +/- 0.1-mu-M) required 5 to 7 days treatment before infection and persisted without additional treatment through more than 4 wk. RT activity in cultures of retinoic acid-treated monocytes reached maximum levels much earlier than those of control cultures, but the minimum tissue culture infectious doses for retinoic acid-treated and untreated monocytes were comparable. Retinoic acid treatment did not affect susceptibility of monocytes to HIV infection. Further, the frequency of infected cells in retinoic acid-treated and control cultures were also comparable: about 20% of cells in each culture expressed HIV proteins or RNA 2 wk after infection. In contrast, levels of HIV-specific RNA and DNA were 3- to 5-fold higher in the retinoic acid-treated over control monocytes 1 wk after infection. That retinoic acid increased levels of HIV gene expression in monocyte cultures without affecting the number of infected cells per culture suggested a transcriptional mechanism for the effect. This was confirmed in the U937 myeloid cell line transfected with HIV LTR linked to a chloramphenicol acetyl transferase reporter gene. Chloramphenicol acetyl transferase activity in lysates of retinoic acid-treated cells were 20-fold higher than that of control cells. These data show that retinoic acid significantly increased HIV replication in monocytes through mechanisms related to cell differentiation and to a direct transcriptional effect on viral gene expression. C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,HIV IMMUNOPATHOGENESIS PROGRAM,WASHINGTON,DC 20307. NR 64 TC 76 Z9 76 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 15 PY 1992 VL 148 IS 8 BP 2539 EP 2546 PG 8 WC Immunology SC Immunology GA HN740 UT WOS:A1992HN74000033 PM 1560208 ER PT J AU BLOEMER, MJ HAUS, JW AF BLOEMER, MJ HAUS, JW TI COMPACT, HIGH-EXTINCTION WAVE-GUIDE POLARIZERS THAT USE LOCALIZED SURFACE-PLASMONS SO OPTICS LETTERS LA English DT Article ID SILVER; GLASS AB We report a new type of waveguide polarizer that utilizes surface plasmon modes localized in nanometer-size silver particles to polarize light. Polarization is due to selective excitation of a lossy surface plasmon mode in the silver. Planar waveguides have been fabricated by a K+-Na+ ion-exchange process in a glass composite containing elongated silver particles. Both TE- and TM-pass polarizers have been fabricated with extinction ratios of > 50 dB/100-mu-m at 836 nm. Propagation losses for the pass axis were < 0.2 dB/10-mu-m. The polarizing properties are modeled by an effective medium theory. C1 RENSSELAER POLYTECH INST,DEPT PHYS,TROY,NY 12180. RP BLOEMER, MJ (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 12 TC 10 Z9 10 U1 1 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD APR 15 PY 1992 VL 17 IS 8 BP 598 EP 600 DI 10.1364/OL.17.000598 PG 3 WC Optics SC Optics GA HM730 UT WOS:A1992HM73000016 PM 19794570 ER PT J AU CRAMER, CJ TRUHLAR, DG AF CRAMER, CJ TRUHLAR, DG TI AN SCF SOLVATION MODEL FOR THE HYDROPHOBIC EFFECT AND ABSOLUTE FREE-ENERGIES OF AQUEOUS SOLVATION SO SCIENCE LA English DT Article ID CAVITY SURFACE-AREA; SEMIEMPIRICAL METHODS; CHARGE MODEL; GAS-PHASE; WATER; PARAMETERS; HYDRATION; AM1; OPTIMIZATION; POTENTIALS AB A model for absolute free energies of solvation of organic, small inorganic, and biological molecules in aqueous solution is described. This model has the following features: (i) the solute charge distribution is described by distributed monopoles, and solute screening of dielectric polarization is treated with no restrictions on solute shape; (ii) the energetic effects of cavity formation, dispersion interactions, and solute-induced restructuring of water are included by a semiempirical cavity surface tension; and (iii) both of these effects are included in the solute Hamiltonian operator for self-consistent field (SCF) calculations to allow solvent-induced electronic and geometric distortion of the solute. The model is parameterized for solutes composed of H, C, N, O, F, P, S, Cl, Br, and I against experimental data for 150 neutral solutes and 28 ions, with mean absolute errors of 0.7 and 2.6 kilocalories per mole, respectively. C1 UNIV MINNESOTA,INST SUPERCOMP,DEPT CHEM,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RP CRAMER, CJ (reprint author), USA,CTR CHEM RES DEV & ENGN,RES DIRECTORATE,DIV PHYS,ABERDEEN PROVING GROUND,MD 21010, USA. RI Truhlar, Donald/G-7076-2015; Cramer, Christopher/B-6179-2011 OI Truhlar, Donald/0000-0002-7742-7294; Cramer, Christopher/0000-0001-5048-1859 NR 78 TC 468 Z9 469 U1 1 U2 23 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD APR 10 PY 1992 VL 256 IS 5054 BP 213 EP 217 DI 10.1126/science.256.5054.213 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA HM896 UT WOS:A1992HM89600026 PM 17744720 ER PT J AU COHEN, JM FAMINI, GR AF COHEN, JM FAMINI, GR TI CALCULATIONS BASED ON THE EIKONAL METHOD SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 12 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK161 UT WOS:A1992HK16101897 ER PT J AU FAMINI, GR KRISHNAN, PN BURKE, LA JENSEN, JO AF FAMINI, GR KRISHNAN, PN BURKE, LA JENSEN, JO TI PENDANT-CHAIN INTERACTIONS IN MODEL COMPOUNDS FOR POLYMERS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 COPPIN STATE COLL,DEPT NAT SCI,BALTIMORE,MD 21226. USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RUTGERS STATE UNIV,DEPT CHEM,CAMDEN,NJ 08102. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 15 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK161 UT WOS:A1992HK16101900 ER PT J AU URBAN, JJ FAMINI, GR AF URBAN, JJ FAMINI, GR TI EXAMINATION OF THE DEGREE OF CONVERGENCE IN AMINO-ACID INTERCONVERSIONS WITH THE MOLECULAR-DYNAMICS FREE-ENERGY PERTURBATION TECHNIQUE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 22 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK161 UT WOS:A1992HK16101907 ER PT J AU BOSSLE, PC ELLZY, MW MARTIN, JJ AF BOSSLE, PC ELLZY, MW MARTIN, JJ TI DETECTION OF THIODIGLYCOL AND ITS SULFOXIDE AND SULFONE ANALOGS IN ENVIRONMENTAL WATERS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 46 EP ANYL PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK161 UT WOS:A1992HK16100393 ER PT J AU SENNETT, MS ZUKAS, WX WENTWORTH, SE AF SENNETT, MS ZUKAS, WX WENTWORTH, SE TI MOLECULAR-DYNAMICS SIMULATION OF EPOXY ADHESIVE MONOMER INTERACTIONS WITH ALUMINA SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,POLYMER RES BRANCH,MAT TECHNOL LAB,WATERTOWN,MA 02172. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 49 EP IEC PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK162 UT WOS:A1992HK16200076 ER PT J AU CLAY, ML YOUNG, VY AF CLAY, ML YOUNG, VY TI DYNAMIC-RESPONSE CHARACTERIZATION OF THE CHLORIDE-ION SELECTIVE ELECTRODE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV FLORIDA,DEPT CHEM,GAINESVILLE,FL 32611. USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 75 EP ANYL PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK161 UT WOS:A1992HK16100421 ER PT J AU KIM, HJ TAUB, IA RICHARDSON, MJ YEOMANS, W AF KIM, HJ TAUB, IA RICHARDSON, MJ YEOMANS, W TI STRUCTURAL INVESTIGATION OF THE INTRINSIC CHEMICAL MARKERS FOR THERMOPROCESSING OF FOODS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RD & E CTR,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 85 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK161 UT WOS:A1992HK16100085 ER PT J AU RAO, M BALAKRISHNAN, K GONZALEZ, RD JOHN, VT AKKARA, J KAPLAN, D ARRANDA, F RAO, D AF RAO, M BALAKRISHNAN, K GONZALEZ, RD JOHN, VT AKKARA, J KAPLAN, D ARRANDA, F RAO, D TI ENZYMATIC-SYNTHESIS OF NOVEL POLYMERS IN MICROSTRUCTURED MEDIA SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,DEPT PHYS,BOSTON,MA 02125. TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. USA,RES DEV & ENGN LABS,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 99 EP BIOT PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK161 UT WOS:A1992HK16100625 ER PT J AU KLAYMAN, DL AF KLAYMAN, DL TI ARTEMISIA-ANNUA - FROM WEED TO RESPECTABLE ANTIMALARIAL PLANT SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 123 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK161 UT WOS:A1992HK16100121 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP TI NATURE AND MECHANISM OF THE REACTION OF DISULFIDES AND TRISULFIDES WITH ORGANOMETALLIC REAGENTS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,FT WASHINGTON,MD 20774. USA,CRDEC,ABERDEEN PROVING GROUND,MD 21021. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 131 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK162 UT WOS:A1992HK16201515 ER PT J AU AKKARA, JA SALAPU, P KAPLAN, DL AF AKKARA, JA SALAPU, P KAPLAN, DL TI POLYANILINE SYNTHESIZED BY ENZYME-CATALYZED REACTIONS IN ORGANIC-SOLVENTS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 189 EP PMSE PN 3 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK163 UT WOS:A1992HK16300811 ER PT J AU URBAN, JJ FAMINI, GR AF URBAN, JJ FAMINI, GR TI COMPUTATIONAL STUDY OF SOLVENT EFFECTS ON THE CONFORMATION OF DOPAMINE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,SMCCR RSP C,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 225 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK162 UT WOS:A1992HK16201609 ER PT J AU LEVY, HB SALAZAR, A REED, W MORALES, J AF LEVY, HB SALAZAR, A REED, W MORALES, J TI STUDIES OF POLYICLC IN AIDS PATIENTS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 ASHFORD HOSP,SAN JUAN,PR. NIAID,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 248 EP PMSE PN 3 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK163 UT WOS:A1992HK16300870 ER PT J AU FAMINI, GR FRYKMAN, EK WILSON, LY AF FAMINI, GR FRYKMAN, EK WILSON, LY TI USING THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS - SOME ADENOSINE ACTIVITIES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 253 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK162 UT WOS:A1992HK16201637 ER PT J AU FAMINI, GR WILSON, LY AF FAMINI, GR WILSON, LY TI USING THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS - SOME SPECTRA SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 254 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK162 UT WOS:A1992HK16201638 ER PT J AU FAMINI, GR WILSON, LY AF FAMINI, GR WILSON, LY TI USING THEORETICAL DESCRIPTORS IN STRUCTURE-ACTIVITY-RELATIONSHIPS - ACETYLCHOLINESTERASE INHIBITION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. LOMA LINDA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 255 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK162 UT WOS:A1992HK16201639 ER PT J AU COHEN, JM AF COHEN, JM TI A SELF-CONSISTENT EIKONAL APPROXIMATION APPLIED TO ELECTRONICALLY DIABATIC COLLISIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CRDEC,SMCCR RSP C,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 293 EP PHYS PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK162 UT WOS:A1992HK16202389 ER PT J AU TAWA, GJ MIELKE, SL FRIEDMAN, RS HALVICK, P TRUHLAR, DG AF TAWA, GJ MIELKE, SL FRIEDMAN, RS HALVICK, P TRUHLAR, DG TI QUANTUM DYNAMICS OF NA(32P)+H2 COLLISIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 NASA,AMES RES CTR,MOFFETT FIELD,CA 94035. UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,DEPT CHEM,PSYCHOPHYSIOL PROGRAM,INST SUPERCOMP,MINNEAPOLIS,MN 55455. RI Mielke, Steven/B-7533-2008; Truhlar, Donald/G-7076-2015 OI Mielke, Steven/0000-0002-1938-7503; Truhlar, Donald/0000-0002-7742-7294 NR 1 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 347 EP PHYS PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK162 UT WOS:A1992HK16202443 ER PT J AU BRODKIN, JS SENGUPTA, LC FRANZEN, W SAGALYN, PL AF BRODKIN, JS SENGUPTA, LC FRANZEN, W SAGALYN, PL TI SURFACE CHARACTERIZATION OF METAL PLATES EXPOSED TO ATOMIC OXYGEN IN SPACE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 400 EP INOR PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK162 UT WOS:A1992HK16200810 ER PT J AU CEBE, P CARBECK, J SCHREUDERGIBSON, H BLUHM, A YEOMANS, W AF CEBE, P CARBECK, J SCHREUDERGIBSON, H BLUHM, A YEOMANS, W TI PRELIMINARY CHARACTERIZATION OF STILBENE-SUBSTITUTED LIQUID-CRYSTAL POLYCARBONATES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 MIT,DEPT MAT SCI & ENGN,CAMBRIDGE,MA 02139. USA,NATICK RES & DEV LABS,CTR DEV & ENGN,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 420 EP POLY PN 3 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK163 UT WOS:A1992HK16300412 ER PT J AU MUNAVALLI, S MULLER, AJ ROSSMAN, DI ROHRBAUGH, DK FERGUSOR, CP AF MUNAVALLI, S MULLER, AJ ROSSMAN, DI ROHRBAUGH, DK FERGUSOR, CP TI SYNTHESIS OF BIS(TRIFLUOROMETHYL) TRISULFIDE AND BIS(TRIFLUOROMETHYLTHIO) SELENIDE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,FT WASHINGTON,MD 20774. USA,CRDEC,ABERDEEN PROVING GROUND,MD 21021. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 460 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK162 UT WOS:A1992HK16201844 ER PT J AU ALSTON, WB AF ALSTON, WB TI STRUCTURE-TO-PROPERTY RELATIONSHIPS IN ADDITION CURED POLYMERS .4. CORRELATIONS BETWEEN THERMOOXIDATIVE WEIGHT LOSSES OF NORBORNENYL CURED POLYIMIDE RESINS AND THEIR COMPOSITES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 NASA,LEWIS RES CTR,USA,AVIAT RES & TECHNOL ACT,CLEVELAND,OH 44135. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 503 EP POLY PN 3 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK163 UT WOS:A1992HK16300493 ER PT J AU BEAUDRY, WT WAGNER, GW WARD, JR AF BEAUDRY, WT WAGNER, GW WARD, JR TI SOLID-STATE P-31 MAS NMR-STUDY OF THE ADSORPTION AND HYDROLYSIS OF ORGANOPHOSPHORUS ESTERS ON SYNTHETIC ION-EXCHANGE RESINS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 5 PY 1992 VL 203 BP 778 EP INOR PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA HK162 UT WOS:A1992HK16201186 ER PT J AU LOOAREESUWAN, S VIRAVAN, C VANIJANONTA, S WILAIRATANA, P SUNTHARASAMAI, P CHAROENLARP, P ARNOLD, K KYLE, D CANFIELD, C WEBSTER, K AF LOOAREESUWAN, S VIRAVAN, C VANIJANONTA, S WILAIRATANA, P SUNTHARASAMAI, P CHAROENLARP, P ARNOLD, K KYLE, D CANFIELD, C WEBSTER, K TI RANDOMIZED TRIAL OF ARTESUNATE AND MEFLOQUINE ALONE AND IN SEQUENCE FOR ACUTE UNCOMPLICATED FALCIPARUM-MALARIA SO LANCET LA English DT Article ID PLASMODIUM-FALCIPARUM; QINGHAOSU ARTEMISININ; ANTIMALARIAL DRUG; PYRIMETHAMINE; SULFADOXINE; THAILAND AB The increasing frequency of therapeutic failures in falciparum malaria in Thailand shows an urgent need for effective drugs or drug combinations. Artesunate, a qinghaosu derivative, is effective in clearing parasitaemia rapidly, but the recrudescence rate can be as high as 50%. We have compared artesunate followed by mefloquine with each drug alone in acute, uncomplicated falciparum malaria. 127 patients were randomly assigned treatment with artesunate (600 mg over 5 days), mefloquine (750 mg then 500 mg 6 h later), or artesunate followed by mefloquine. All patients were admitted to hospital for 28 days to exclude reinfection. Cure was defined as no recrudescence during the 28 days' follow-up. The cure rates for mefloquine and artesunate alone were 81% (30/37 patients) and 88% (35/40); the combination was effective in all of 39 patients. Fever and parasite clearance times were significantly shorter in the groups that received artesunate than in the mefloquine-only group. The frequency of nausea and vomiting was slightly, but not significantly, higher among patients who received both drugs than in the other groups. The combination of artesunate followed by mefloquine is highly effective and well tolerated in patients with acute, uncomplicated falciparum malaria in Thailand. C1 ROCHE ASIAN RES FDN,HONG KONG,HONG KONG. USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. PHARMACEUT SYST INC,GAITHERSBURG,MD. RP LOOAREESUWAN, S (reprint author), MAHIDOL UNIV,BANGKOK HOSP TROP DIS,FAC TROP MED,4206 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 23 TC 123 Z9 124 U1 0 U2 2 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD APR 4 PY 1992 VL 339 IS 8797 BP 821 EP 824 DI 10.1016/0140-6736(92)90276-9 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA HM441 UT WOS:A1992HM44100001 PM 1347854 ER PT J AU LEADER, H GORDON, RK BAUMGOLD, J BOYD, VL NEWMAN, AH SMEJKAL, RM CHIANG, PK AF LEADER, H GORDON, RK BAUMGOLD, J BOYD, VL NEWMAN, AH SMEJKAL, RM CHIANG, PK TI MUSCARINIC RECEPTOR SUBTYPE SPECIFICITY OF (N,N-DIALKYLAMINO)ALKYL 2-CYCLOHEXYL-2-PHENYLPROPIONATES - CYLEXPHENES (CYCLOHEXYL-SUBSTITUTED APROPHEN ANALOGS) SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID POTENT ANTIMUSCARINIC AGENT; ACETYLCHOLINE-RECEPTORS; BINDING-PROPERTIES; ANTAGONISTS; INHIBITION; CELLS; PIRENZEPINE; SELECTIVITY; AZAPROPHEN; SECRETION AB A series of aprophen [N,N-diethylamino)ethyl 2,2-diphenylpropionate] analogues, called cylexphenes, were synthesized with alterations in (1) the chain length of the amine portion of the ester, (2) the alkyl groups on the amino alcohol, and (3) a cyclohexyl group replacing one of the phenyl rings. The antimuscarinic activities of these analogues were assessed in two pharmacological assays: the inhibition of acetylcholine-induced contraction of guinea pig ileum, and the blocking of carbachol-stimulated release of alpha-amylase from rat pancreatic acinar cells. These two tissues represent the M3(ileum) and M3(pancreas) muscarinic receptor subtypes. In addition, the analogues were also evaluated for their competitive inhibition of the binding of [H-3]NMS to selected cell membranes, each containing only one of the m1, M2, m3, or M4 muscarinic receptor subtypes. The m1 and m3 receptors were stably transfected into A9 L cells. The replacement of one phenyl group of aprophen with a cyclohexyl group increased the selectivity of all the analogues for the pancreatic acinar muscarinic receptor subtype over the ileum subtype by more than 10-fold, with the (N,N-dimethylamino)propyl analogue exhibiting the greatest selectivity for the pancreas receptor subtype, over 30-fold. The cylexphenes also showed a decrease in potency in comparison to the parent compound when examined for the binding of [H-3]NMS to the M2 subtype. In agreement with the pharmacological data obtained from the pancreas, the (N,N-dimethylamino)propyl cylexphene 3 demonstrated the greatest selectivity for the m3 subtype, and additionally showed a preference for the m1 and M4 receptor subtypes over the M2 receptor subtype in the binding assay. Thus, this compound showed a potent selectivity according to the pharmacological and binding assays between the muscarinic receptor subtypes of the pancreas and ileum. In both the pharmacological and binding assays, the potency of the analogues decreased markedly when the chain length and the bond distance between the carbonyl oxygen and protonated nitrogen were increased beyond three methylene groups. When the structures of these analogues were analyzed using a molecular modeling program, the bond distance between the carbonyl oxygen and protonated nitrogen was deduced to be more important for the antagonist activity than subtype specificity. C1 GEORGE WASHINGTON UNIV,DEPT RADIOL,WASHINGTON,DC 20037. WALTER REED ARMY MED CTR,DIV BIOCHEM,APPL BIOCHEM BRANCH,WASHINGTON,DC 20307. NR 38 TC 8 Z9 8 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD APR 3 PY 1992 VL 35 IS 7 BP 1290 EP 1295 DI 10.1021/jm00085a017 PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA HM691 UT WOS:A1992HM69100017 PM 1560441 ER PT J AU RAINS, VS DITZLER, TF AF RAINS, VS DITZLER, TF TI SLEEP DISORDERS AND AGING SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID HIP FRACTURE; HALF-LIFE; BENZODIAZEPINES; RISK; LONG C1 TRIPLER ARMY MED CTR,TRISERV ALCOHOLISM RECOVERY FACIL,HONOLULU,HI 96859. RP RAINS, VS (reprint author), VET AFFAIRS MED CTR,MARTINEZ,CA 94553, USA. NR 10 TC 1 Z9 1 U1 1 U2 1 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD APR 2 PY 1992 VL 326 IS 14 BP 956 EP 956 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA HL261 UT WOS:A1992HL26100024 PM 1542355 ER PT J AU KARLE, JM KARLE, IL GORDON, RK CHIANG, PK AF KARLE, JM KARLE, IL GORDON, RK CHIANG, PK TI RELATIONSHIP OF 3-DIMENSIONAL STRUCTURE OF MUSCARINIC ANTAGONISTS TO ANTIMUSCARINIC ACTIVITY - STRUCTURE OF THIODEACYLAPROPHEN HYDROCHLORIDE SO ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE LA English DT Article ID RECEPTORS; APROPHEN; AZAPROPHEN; ANALOGS; AGENT AB C20H28NS+ .Cl-, 2-(diethylamino)ethyl 1,1-diphenylethyl sulfide hydrochloride (thiodeacylaprophen hydrochloride), M(r) = 349.9, orthorhombic, P2(1)2(1)2(1), a = 8.933 (2), b = 11.710 (3), c = 18.934 (4) angstrom, V = 1980.6 (7) angstrom 3, Z = 4, D(x) = 1.173 g cm-3, Cu k(alpha), lambda = 1.54178 angstrom, mu = 26.70 cm-1, F(000) = 752, room temperature, final R = 4.1% for 1417 reflections with \F0\ > 3-sigma(F). Thiodeacylaprophen crystallized as a tertiary amine hydrochloride salt. The S-C-C-N+ segment adopts a trans configuration as does one of the C(phenyl)-C-S-C segments. A comparison of the structure of thiodeacylaprophen with the crystal structures of poten antimuscarinic agents suggests that the relatively weak antimuscarinic activity of thiodeacylaprophen compared to atropine and aprophen may be substantially due to the short intramolecular S...N+ distance of 4.106 (6) angstrom. Other contributing structural factors may include the direction of the N+-H bond and restricted accessibility of the sulfur atom for interatomic interactions. C1 USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375. WALTER REED ARMY MED CTR,DIV BIOCHEM,WASHINGTON,DC 20307. RP KARLE, JM (reprint author), WALTER REED ARMY MED CTR,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 27 TC 3 Z9 3 U1 0 U2 1 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0108-7681 J9 ACTA CRYSTALLOGR B JI Acta Crystallogr. Sect. B-Struct. Commun. PD APR 1 PY 1992 VL 48 BP 208 EP 213 DI 10.1107/S0108768191013149 PN 2 PG 6 WC Chemistry, Multidisciplinary; Crystallography SC Chemistry; Crystallography GA HP118 UT WOS:A1992HP11800014 PM 1515109 ER PT J AU BERNTON, EW BRYANT, HU DECOSTER, MA ORENSTEIN, JM RIBAS, JL MELTZER, MS GENDELMAN, HE AF BERNTON, EW BRYANT, HU DECOSTER, MA ORENSTEIN, JM RIBAS, JL MELTZER, MS GENDELMAN, HE TI NO DIRECT NEURONOTOXICITY BY HIV-1 VIRIONS OR CULTURE FLUIDS FROM HIV-1-INFECTED T-CELLS OR MONOCYTES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; IMMUNE-DEFICIENCY SYNDROME; GLUTAMATE NEUROTOXICITY; ENVELOPE PROTEIN; MYCOPLASMA; MACROPHAGE; INFECTION; ANTIBODIES; ALPHA AB Macrophages and microglia are the principal target cells for human immunodeficiency virus (HIV) in brain, and as such, are likely participants in the neuropathology of HIV infection. In a model system for this process, we found that fluids from human monocyte cultures enhanced survival and differentiation of the neurons in fetal rat brain explants. In contrast, fluids from HIV-infected monocyte cultures were strongly toxic to neurons and paradoxically enhanced the proliferation of glial cells. Further, neuronotoxic activity in these fluids was mediated through activation of NMDA binding receptors on the neurons and was inhibited by any of several different NMDA antagonists. Neuronotoxic activity was directly related to contamination of the HIV virus stock with Mycoplasma arginini and M. hominis. Pure cultures of mycoplasma, bacterial lipopolysaccharide (LPS), or murine recombinant tumor necrosis factor alpha (rTNF-alpha) each induced neuronotoxicity which exactly mirrored that induced by the contaminated HIV stock. It is likely that mycoplasma or components of the mycoplasma plasma membrane stimulate TNF-alpha production by the glial cells in the brain explants. Indeed, careful depletion of glial cells in these explants prevented mycoplasma or LPS-mediated neuronotoxicity. No neuronotoxicity was evident with HIV-1 virus stock, HIV-1 gp120, or culture fluids from HIV-infected T cells or monocytes when these preparations were free of contamination by mycoplasma and LPS. These findings suggest caution in interpretation of those experiments in which similar contamination has not been rigorously excluded. C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. GEORGE WASHINGTON UNIV,SCH MED,DEPT PATHOL,WASHINGTON,DC 20307. HENRY M JACKSON FDN,ROCKVILLE,MD 20850. RP BERNTON, EW (reprint author), WALTER REED ARMY MED CTR,DEPT NEUROPHARMACOL,WASHINGTON,DC 20307, USA. NR 32 TC 50 Z9 50 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD APR PY 1992 VL 8 IS 4 BP 495 EP 503 DI 10.1089/aid.1992.8.495 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA HR877 UT WOS:A1992HR87700011 PM 1599756 ER PT J AU SMOLIN, MR GORMAN, PD GAITHER, NS WORTHAM, DC AF SMOLIN, MR GORMAN, PD GAITHER, NS WORTHAM, DC TI ORIGIN OF THE RIGHT CORONARY-ARTERY FROM THE LEFT MAIN CORONARY-ARTERY IDENTIFIED BY TRANSESOPHAGEAL ECHOCARDIOGRAPHY SO AMERICAN HEART JOURNAL LA English DT Note ID ANOMALIES RP SMOLIN, MR (reprint author), WALTER REED ARMY MED CTR,CARDIOL SERV,WASHINGTON,DC 20307, USA. NR 7 TC 7 Z9 7 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD APR PY 1992 VL 123 IS 4 BP 1062 EP 1065 DI 10.1016/0002-8703(92)90721-7 PN 1 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA HL737 UT WOS:A1992HL73700038 PM 1549974 ER PT J AU MENNING, BW AF MENNING, BW TI GUNS FOR THE CZAR - AMERICAN TECHNOLOGY AND THE SMALL ARMS INDUSTRY IN 19TH-CENTURY RUSSIA - BRADLEY,J SO AMERICAN HISTORICAL REVIEW LA English DT Book Review RP MENNING, BW (reprint author), USA,COMMAND & GEN STAFF COLL,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER HISTORICAL REVIEW PI WASHINGTON PA 400 A ST SE, WASHINGTON, DC 20003 SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD APR PY 1992 VL 97 IS 2 BP 584 EP 585 DI 10.2307/2165830 PG 2 WC History SC History GA HP914 UT WOS:A1992HP91400119 ER PT J AU HICKEY, DR AF HICKEY, DR TI A GENTLEMANLY AND HONORABLE PROFESSION - THE CREATION OF THE UNITED-STATES NAVAL OFFICER CORPS, 1794-1815 - MCKEE,C SO AMERICAN HISTORICAL REVIEW LA English DT Book Review RP HICKEY, DR (reprint author), USA,COMMAND & GEN STAFF COLL,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER HISTORICAL REVIEW PI WASHINGTON PA 400 A ST SE, WASHINGTON, DC 20003 SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD APR PY 1992 VL 97 IS 2 BP 612 EP 613 DI 10.2307/2165865 PG 2 WC History SC History GA HP914 UT WOS:A1992HP91400155 ER PT J AU FRIEDL, KE DELUCA, JP MARCHITELLI, LJ VOGEL, JA AF FRIEDL, KE DELUCA, JP MARCHITELLI, LJ VOGEL, JA TI RELIABILITY OF BODY-FAT ESTIMATIONS FROM A 4-COMPARTMENT MODEL BY USING DENSITY, BODY-WATER, AND BONE-MINERAL MEASUREMENTS SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE BODY COMPOSITION; BODY FAT; DENSITOMETRY; BODY-WATER ANALYSIS; X-RAY ABSORPTIOMETRY; BONE MASS; RELIABILITY; MULTICOMPARTMENT MODELS; ELECTRICAL IMPEDANCE ID ABSORPTIOMETRY; MASS; FLUIDS; VOLUME; WEIGHT; WOMEN AB Reliability of body-fat estimation by a four-compartment model was tested in 10 subjects. Body densities were measured by underwater weighing (UWW), total body water (TBW) by deuterium dilution, and total body bone mass (TBBM) by dual-energy x-ray absorptiometry in three sessions in 1 wk. Percent body fat was determined by [2.559/density -0.734 (TBW/weight) + 0.983 (TBBM/weight) - 1.841] x 100. Reliability coefficients were 0.991 and 0.994, and within-subjects standard deviations were +/- 1.0 and +/- 1.1 for percent body-fat estimations from Siri's two-compartment and the four-compartment models, respectively; fat mass was +/- 0.8 kg with both models. These data suggest that additive errors in the multicompartment model do not offset the improved accuracy of fat estimations over those obtained from UWW alone. The greatest source of error came from the UWW procedure itself (+/- 0.002 g/cm3, or almost-equal-to 1.0% of body weight), followed by error in TBW (+/- 0.5 L). More reproducible passive methods that are not dependent on hydration or TBBM may be especially useful after validation against the four-compartment model. RP FRIEDL, KE (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT PHYSIOL,NATICK,MA 01760, USA. OI Friedl, Karl/0000-0002-3134-8427 NR 34 TC 127 Z9 128 U1 1 U2 2 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-2310, BETHESDA, MD 20814-3998 SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD APR PY 1992 VL 55 IS 4 BP 764 EP 770 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA HM118 UT WOS:A1992HM11800001 PM 1550056 ER PT J AU PANDOLF, KB GANGE, RW LATZKA, WA BLANK, IH YOUNG, AJ SAWKA, MN AF PANDOLF, KB GANGE, RW LATZKA, WA BLANK, IH YOUNG, AJ SAWKA, MN TI HUMAN THERMOREGULATORY RESPONSES DURING COLD WATER IMMERSION AFTER ARTIFICIALLY INDUCED SUNBURN SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE BLOOD RESPONSES; EXERCISE-COLD STRESS; PERCEPTUAL RESPONSES; PHYSIOLOGICAL RESPONSES; TEMPERATURE REGULATION; ULTRAVIOLET ERYTHEMA; ULTRAVIOLET RADIATION ID ULTRAVIOLET-RADIATION; TEMPERATURE-CHANGES; HUMAN-SKIN; IRRADIATION; EXERCISE; BLOOD AB Thermoregulatory responses during cold-water immersion (water temperature 22-degrees-C) were compared in 10 young men before as well as 24 h and 1 wk after twice the minimal erythemal dose of ultraviolet-B radiation that covered approximately 85% of the body surface area. After 10 min of seated rest in cold water, the men exercised for 50 min on a cycle ergometer (approximately 51% of maximal aerobic power). Rectal temperature, regional and mean heat flow (h(c)-), mean skin temperature from five sites, and heart rate were measured continuously for all volunteers while esophageal temperature was measured for six subjects. Venous blood samples were collected before and after cold water immersion. The mean skin temperature was higher (P < 0.05) throughout the 60-min cold water exposure both 24 h and 1 wk after sunburn compared with before sunburn. Mean h(c) was higher (P < 0.05) after 10 min resting immersion and during the first 10 min of exercise when 24 h postsunburn was compared with presunburn, with the difference attributed primarily to higher h(c) from the back and chest. While rectal temperature and heart rate did not differ between conditions, esophageal temperature before immersion and throughout the 60 min of cold water immersion was higher (P < 0.05) when 24 h postsunburn was compared with presunburn. Plasma volume increased (P < 0.05) after 1 wk postsunburn compared with presunburn, whereas plasma protein concentration was reduced (P < 0.05). After exercise cortisol was greater (P < 0.05) 24 h postsunburn compared with either presunburn or 1 wk postsunburn. Rated perceived exertion and thermal sensation during the 60 min of cold water immersion did not differ between conditions. In conclusion, artificially induced sunburn impaired the ability of these men to vasoconstrict during cold water immersion, resulting in greater heat loss. These adverse thermoregulatory effects were still present 1 wk after sunburn when the associated erythema had disappeared. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,WELLMAN LABS PHOTOMED,BOSTON,MA 02114. RP PANDOLF, KB (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 32 TC 9 Z9 9 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD APR PY 1992 VL 262 IS 4 BP R617 EP R623 PN 2 PG 7 WC Physiology SC Physiology GA HQ056 UT WOS:A1992HQ05600065 PM 1566926 ER PT J AU PANDOLF, KB GANGE, RW LATZKA, WA BLANK, IH KRANING, KK GONZALEZ, RR AF PANDOLF, KB GANGE, RW LATZKA, WA BLANK, IH KRANING, KK GONZALEZ, RR TI HUMAN THERMOREGULATORY RESPONSES DURING HEAT EXPOSURE AFTER ARTIFICIALLY INDUCED SUNBURN SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE BLOOD RESPONSES; EXERCISE-HEAT STRESS; PERCEPTUAL RESPONSES; PHYSIOLOGICAL RESPONSES; SWEATING RESPONSES; TEMPERATURE REGULATION; ULTRAVIOLET ERYTHEMA; ULTRAVIOLET RADIATION ID ECCRINE SWEAT GLAND; EXERCISE; ERYTHEMA; BLOOD; SKIN AB Thermoregulatory responses in the heat (ambient temperature 49-degrees-C, 20% relative humidity, 1 m/s wind) were investigated in 10 unacclimated men during 50 min of cycle ergometer exercise (approximately 53% of maximal aerobic power) after a 10-min rest before as well as 24 h and 1 wk after twice the minimal erythemal dose of UV-B radiation that covered approximately 85% of the body surface area. In 7 subjects esophageal temperature (T(es)) was recorded while in all 10 subjects five-site skin and rectal temperatures, heart rate, and back, left forearm, and shielded (12 cm2 area) right forearm sweating rates (m(sw)) were recorded at 15-s intervals. Venous blood was collected before and after exercise-heat stress. Mean skin temperature, T(es), rectal temperature, heart rate, and total body sweating rate were not significantly (P > 0.05) affected by sunburn. Pre- and postexercise values of hematocrit, hemoglobin, plasma protein, plasma volume, and plasma osmolality were also not affected (P > 0.05) by sunburn. Analysis of presunburn and post-sunburn data showed that the T(es) intercept for sweating (degrees-C) was unaffected (P > 0.05), but m(sw)/T(es) and final m(sw) from the left forearm (m(sw)/T(es)) 0.24 +/- 0.02 vs. 0.17 +/- 0.01 mg.cm-2.min-1.degrees-C-1, P < 0.05; m(sw) 0.60 +/- 0.05 vs. 0.37 +/- 0.02, mg.cm-2.min-1, P < 0.05) and back (m(sw)/T(es) 0.43 +/- 0.03 vs. 0.36 +/- 0.01 mg.cm-2.min-1.degrees-C-1, P = 0.052; m(sw) 1.08 +/- 0.09 vs. 0.74 +/- 0.05 mg.cm-2.min-1, P < 0.05) were significantly reduced 24 h postsunburn. Because the protected right forearm m(sw)/T(es) (0.26 +/- 0.01 vs. 0.26 +/- 0.01 mg.cm-2.min-1.degrees-C-1) and final m(sw) (0.63 +/- 0.06 vs. 0.54 +/- 0.03 mg.cm-2.min-1) were not impeded (P > 0.05) by sunburn, decrements in sudomotor drive and level of hydration were not factors in the response. In addition, rated perceived exertion at 45 min and thermal sensation at 30 min of exercise in the heat were significantly greater (P < 0.05) 24 h and 1 wk postsunburn compared with presunburn. These data suggested that after sunburn there was an effect, locally mediated, on both the responsiveness and capacity of the sweat gland. C1 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,WELLMAN LABS PHOTOMED,BOSTON,MA 02114. RP PANDOLF, KB (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 32 TC 13 Z9 14 U1 1 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD APR PY 1992 VL 262 IS 4 BP R610 EP R616 PN 2 PG 7 WC Physiology SC Physiology GA HQ056 UT WOS:A1992HQ05600064 PM 1566925 ER PT J AU CHILDS, JE SCHWARTZ, BS KSIAZEK, TG GRAHAM, RR LEDUC, JW GLASS, GE AF CHILDS, JE SCHWARTZ, BS KSIAZEK, TG GRAHAM, RR LEDUC, JW GLASS, GE TI RISK-FACTORS ASSOCIATED WITH ANTIBODIES TO LEPTOSPIRES IN INNER-CITY RESIDENTS OF BALTIMORE - A PROTECTIVE ROLE FOR CATS SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Note AB Leptospiral antibody prevalence was 16% in residents of Baltimore. Seropositivity was associated with age, gender, race, and bird ownership, and negatively associated with contact with rat excrement and cat ownership. Current cat ownership reduced the antibody risk associated with age and race from odds ratios (95% confidence interval) of 3.3 (2.0, 5.5) and 3.3 (1.1, 9.3), respectively, to the baseline level. These data establish the high prevalence of leptospiral antibody in Baltimore and suggest a protective role for cats in reducing the risk of human infection. C1 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,BALTIMORE,MD 21205. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. RP CHILDS, JE (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,615 N WOLFE ST,BALTIMORE,MD 21205, USA. RI Childs, James/B-4002-2012 NR 28 TC 38 Z9 39 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD APR PY 1992 VL 82 IS 4 BP 597 EP 599 DI 10.2105/AJPH.82.4.597 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA HT246 UT WOS:A1992HT24600024 PM 1546785 ER PT J AU ROWTON, ED DEMATA, M RIZZO, N PORTER, CH NAVIN, TR AF ROWTON, ED DEMATA, M RIZZO, N PORTER, CH NAVIN, TR TI ISOLATION OF LEISHMANIA-BRAZILIENSIS FROM LUTZOMYIA-OVALLESI (DIPTERA, PSYCHODIDAE) IN GUATEMALA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ISOENZYME CHARACTERIZATION; CUTANEOUS LEISHMANIASIS AB Leishmania brailiensis is endemic in Guatemala and Belize in Central America. To help identify the vector(s) of this parasite in Guatemala, phlebotomine sand flies that were aspirated from the clothing of collectors at Tikal National Park in the Department of the Peten were examined for flagellates. Lutzomyia ovallesi was found infected with flagellates that were identified as L. braziliensis by isoenzyme electrophoresis. The isoenzyme profile of this isolate matched those from humans from the same area. C1 UNIV VALLE,CIET,MED ENTOMOL RES & TRAINING UNIT,GUATEMALA CITY,GUATEMALA. CTR DIS CONTROL,NATL CTR INFECT DIS,DIV PARASIT DIS,ATLANTA,GA 30333. RP ROWTON, ED (reprint author), WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 NR 10 TC 14 Z9 18 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1992 VL 46 IS 4 BP 465 EP 468 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA HT819 UT WOS:A1992HT81900015 PM 1575293 ER PT J AU KAIN, KC WIRTZ, RA FERNANDEZ, I FRANKE, ED RODRIGUEZ, MH LANAR, DE AF KAIN, KC WIRTZ, RA FERNANDEZ, I FRANKE, ED RODRIGUEZ, MH LANAR, DE TI SEROLOGIC AND GENETIC-CHARACTERIZATION OF PLASMODIUM-VIVAX FROM WHOLE BLOOD-IMPREGNATED FILTER-PAPER DISKS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CIRCUMSPOROZOITE PROTEIN; FALCIPARUM; ANTIBODY AB The presence in the New World of a variant strain of Plasmodium vivax (VK247) containing a unique circumsporozoite (CS) repeat domain was determined by the detection of antibodies to the variant CS protein and by genetic analysis of the CS gene from field isolates. Whole blood specimens were collected on filter paper from patients infected with P. vivax in Mexico and Peru. Plasmodium vivax DNA was eluted from filter paper samples and the CS gene was amplified by the polymerase chain reaction (PCR) and analyzed for the presence of VK247 or VK210 DNA by oligoprobe hybridization. Sera eluted from a companion filter paper sample were screened for antibodies reactive with the predominant and variant repeat peptides by enzyme-linked immunosorbent assays (ELISA) and with sporozoites by the immunofluorescent antibody (IFA) test. All 24 patients were positive by PCR and oligoprobe hybridization for either VK210 (16 of 24), VK247 (3 of 24), or both (5 of 24). Mixed infections were common (5 of 7) in Peru, but were not observed in the Mexican isolates (0 of 17). All three VK247 infections from Mexico occurred in residents of the foothills above Tapachula (P = 0.02). Of patients with smear-positive P. vivax infection, 42% (10 of 24) had detectable antibodies eluted from dried blood dots that were reactive with the CS protein by IFA or ELISA. These findings establish the widespread distribution of the P. vivax variant CS protein in the New World and indicate that dried blood filter paper samples represent a valuable source of material for the serologic and molecular analysis of plasmodial infections. C1 CTR INVEST PALUDISMO,MEXICO CITY 30700,MEXICO. NAVAL MED RES INST DETACHMENT,APO AA 34031,LIMA,PERU. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307. RI Lanar, David/B-3560-2011; Villasante, Eileen/G-3602-2011 NR 13 TC 35 Z9 36 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1992 VL 46 IS 4 BP 473 EP 479 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA HT819 UT WOS:A1992HT81900017 PM 1575295 ER PT J AU ROMOSER, WS FARAN, ME BAILEY, CL LERDTHUSNEE, K AF ROMOSER, WS FARAN, ME BAILEY, CL LERDTHUSNEE, K TI AN IMMUNOCYTOCHEMICAL STUDY OF THE DISTRIBUTION OF RIFT-VALLEY FEVER VIRUS IN THE MOSQUITO CULEX-PIPIENS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID EQUINE ENCEPHALOMYELITIS VIRUS; ENCEPHALITIS-VIRUS; CULISETA-MELANURA; VECTOR; DISSEMINATION; INFECTION; DIPTERA; MIDGUT AB The dissemination of Rift Valley fever (RVF) virus in females of the epidemic vector Culex pipiens was studied immunocytochemically. Among orally infected specimens, viral antigen was detected in all major midgut regions, although individuals varied with respect to which regions were infected. Among specimens with disseminated infections (infections beyond the midgut epithelium), antigen was detected in most tissues, including those of the nervous and endocrine systems. However, no antigen was found in the ovarian follicular epithelia, oocytes/nurse cells, or female accessory gland. A viral dissemination index (DI) based on several tissues was determined for each orally infected specimen and used to estimate the extent of viral dissemination in the hemocoel. Plots of DI values as a function of time after ingestion of an infectious blood meal indicated that dissemination was sporadic, and that once virus escapes from the midgut, its spread to other tissues is rapid. The most common sequence of tissue/organ infection following escape of virus from the midgut epithelium appears to be as follows: intussuscepted foregut, fat body, salivary glands and thoracic ganglia, epidermis, and ommatidia of the compound eyes. Reduced fecundity and survival identified in other studies of RVF virus-infected Cx. pipiens are probably explainable on the basis of extensive tissue and organ infection resulting in an overall energy drain. Infection of regulatory tissues and organs such as the ganglia of the central nervous system, neurosecretory cells, and the corpora allata may also have detrimental effects on the overall functioning of a mosquito, even in the absence of widespread infection. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP ROMOSER, WS (reprint author), OHIO UNIV,DEPT ZOOL & BIOMED SCI,INST TROP & GEOG DIS,ATHENS,OH 45701, USA. NR 37 TC 26 Z9 28 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1992 VL 46 IS 4 BP 489 EP 501 PG 13 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA HT819 UT WOS:A1992HT81900019 PM 1575297 ER PT J AU ANHOLM, JD POWLES, ACP DOWNEY, R HOUSTON, CS SUTTON, JR BONNET, MH CYMERMAN, A AF ANHOLM, JD POWLES, ACP DOWNEY, R HOUSTON, CS SUTTON, JR BONNET, MH CYMERMAN, A TI OPERATION EVEREST II - ARTERIAL OXYGEN-SATURATION AND SLEEP AT EXTREME SIMULATED ALTITUDE SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article ID PERFORMANCE; DISRUPTION; SENSITIVITY; HYPOXEMIA; HYPOXIA; HUMANS AB Frequent sleep disturbances and desaturation during sleep are common at high altitude, but few data are available from the highest altitudes at which humans are known to sleep. Because sleep fragmentation at low altitude may impair mental function and oxygen deprivation produces lasting central nervous system abnormalities, a better understanding of the severity of sleep disturbances and oxygen desaturation at extreme altitudes is important. The purpose of this study was to determine the severity of sleep disturbance and the extent of arterial oxygen desaturation at extreme simulated altitude. Out of eight healthy male subject volunteers who started, five aged 27.2 +/- 1.5 yr completed the study during 6 weeks of progressive hypobaric hypoxia in a decompression chamber. The men were studied at barometric pressures of 760, 429, 347, 282 mm Hg and following return to 760 mm Hg. All demonstrated frequent nighttime awakenings (37.2 awakenings per subject per night at 282 mm Hg, decreasing significantly to 14.8 on return to sea level, p < 0.05). Total sleep time decreased from 337 +/- 30 min at 760 mm Hg to 167 +/- 44 min at 282 mm Hg (p < 0.01). Rapid eye movement (REM) sleep decreased from 17.9% +/- 6.0% of sleep time at sea level to 4.0% +/- 3.3% at 282 mm Hg (p < 0.01). Sleep continuity as reflected by brief arousals increased from 22 +/- 6 arousals per hour of sleep at sea level to 161 +/- 66 arousals per hour at 282 mm Hg (p < 0.01). All subjects showed arterial oxygen desaturation proportional to the altitude. The average oxygen saturation (SaO2) was 79% +/- 3% at 429 mm Hg, 66% +/- 6% at 347 mm Hg, and 52% +/- 2% at 282 mm Hg. Sleep stage had only a minimal effect on SaO2 at any altitude. SaO2 was negatively correlated with brief sleep arousals, r = -0.72, p < 0.01. All subjects demonstrated periodic breathing with apneas throughout much of the night at 347 and 282 mm Hg. These data indicate that sleep quality progressively worsens as SaO2 decreases despite lack of progressive changes in sleep stages at altitude. This study extends previous information on the severity of desaturation during sleep, and suggests that improvements in oxygenation might prove beneficial in restoring consolidated sleep, possibly even improving daytime performance. C1 LOMA LINDA UNIV,DEPT MED,LOMA LINDA,CA 92350. MCMASTER UNIV,MED CTR,DEPT MED,CARDIORESP UNIT,HAMILTON L8S 4L8,ONTARIO,CANADA. USA,ENVIRONM MED RES INST,DIV ALTITUDE RES,NATICK,MA 01760. NR 33 TC 94 Z9 95 U1 1 U2 7 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1992 VL 145 IS 4 BP 817 EP 826 PG 10 WC Respiratory System SC Respiratory System GA HM120 UT WOS:A1992HM12000017 PM 1554208 ER PT J AU ROGERS, KR FERNANDO, JC THOMPSON, RG VALDES, JJ ELDEFRAWI, ME AF ROGERS, KR FERNANDO, JC THOMPSON, RG VALDES, JJ ELDEFRAWI, ME TI DETECTION OF NICOTINIC RECEPTOR LIGANDS WITH A LIGHT ADDRESSABLE POTENTIOMETRIC SENSOR SO ANALYTICAL BIOCHEMISTRY LA English DT Article ID ACETYLCHOLINE-RECEPTOR; IONIC CHANNEL; ALPHA-BUNGAROTOXIN; BINDING; ELECTROPLAX; IMMUNOASSAY; COMPLEX; MUSCLE; SITES; ASSAY C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201. USA,CTR RES DEV & ENGN,DIV BIOTECHNOL,EDGEWOOD,MD 21010. NR 46 TC 15 Z9 15 U1 1 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD APR PY 1992 VL 202 IS 1 BP 111 EP 116 DI 10.1016/0003-2697(92)90215-S PG 6 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA HK719 UT WOS:A1992HK71900020 PM 1621972 ER PT J AU THWAITES, BK STAMATOS, JM CROWL, FD COHEN, AJ VERNALIS, MN CAMBIER, PA AF THWAITES, BK STAMATOS, JM CROWL, FD COHEN, AJ VERNALIS, MN CAMBIER, PA TI TRANSESOPHAGEAL ECHOCARDIOGRAPHIC DIAGNOSIS OF INTRAAORTIC THROMBUS DURING COARCTATION REPAIR SO ANESTHESIOLOGY LA English DT Article DE COMPLICATION, INTRAAORTIC THROMBUS; MONITORING, TRANSESOPHAGEAL ECHOCARDIOGRAPHY; SURGERY, COARCTATION OF THE AORTA ID TWO-DIMENSIONAL ECHOCARDIOGRAPHY; ESOPHAGEAL; SURGERY; AORTA C1 WALTER REED ARMY MED CTR,DEPT CARDIOTHORAC SURG,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CARDIOL,WASHINGTON,DC 20307. RP THWAITES, BK (reprint author), WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307, USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD APR PY 1992 VL 76 IS 4 BP 638 EP 639 DI 10.1097/00000542-199204000-00023 PG 2 WC Anesthesiology SC Anesthesiology GA HL558 UT WOS:A1992HL55800023 PM 1550290 ER PT J AU HAHN, MB BETTENCOURT, JA MCCREA, WB AF HAHN, MB BETTENCOURT, JA MCCREA, WB TI INVIVO STERILIZATION OF AN INFECTED LONG-TERM EPIDURAL CATHETER SO ANESTHESIOLOGY LA English DT Article DE ANESTHETIC TECHNIQUES, EPIDURAL, INFECTION; ANTIBIOTICS, VANCOMYCIN C1 UNIFORMED SERV UNIV HLTH SCI,F EDWARD HERBERT SCH MED,DEPT ANESTHESIOL,BETHESDA,MD 20814. RP HAHN, MB (reprint author), WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307, USA. NR 7 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD APR PY 1992 VL 76 IS 4 BP 645 EP 646 DI 10.1097/00000542-199204000-00026 PG 2 WC Anesthesiology SC Anesthesiology GA HL558 UT WOS:A1992HL55800026 PM 1550291 ER PT J AU BROWN, AE ROSENBERG, R NGAMPOCHJANA, M AF BROWN, AE ROSENBERG, R NGAMPOCHJANA, M TI THE INFECTIVE EFFICIENCY OF INTRADERMALLY INOCULATED PLASMODIUM-COATNEYI SPOROZOITES SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Note C1 ARMED FORCES RES INST MED SCI,DEPT ENTOMOL,BANGKOK 10400,THAILAND. ARMED FORCES RES INST MED SCI,DEPT VET MED,BANGKOK 10400,THAILAND. RP BROWN, AE (reprint author), ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,3156 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 11 TC 1 Z9 1 U1 0 U2 0 PU CARFAX PUBL CO PI ABINGDON PA PO BOX 25, ABINGDON, OXFORDSHIRE, ENGLAND OX14 3UE SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD APR PY 1992 VL 86 IS 2 BP 193 EP 195 PG 3 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA HZ143 UT WOS:A1992HZ14300015 PM 1417212 ER PT J AU MILLER, SA JAMES, RH SLINEY, DH AF MILLER, SA JAMES, RH SLINEY, DH TI INDIRECT OPHTHALMOSCOPES - EVALUATION FOR POTENTIAL HAZARD SO APPLIED OPTICS LA English DT Article DE INDIRECT OPHTHALMOSCOPE; HAZARD ANALYSIS; OPTICAL RADIATION ID RADIATION AB The optical radiation emitted from eight indirect ophthalmoscopes was measured. The levels were compared with the threshold limit values (TLVs) published by the American Conference of Governmental Industrial Hygienists. Many tested instruments were found to emit unnecessarily high levels of ultraviolet and infrared radiation in addition to visible light. The levels of optical radiation emitted from most of the ophthalmoscopes were below the applicable TLVs. Nevertheless, suitable blocking filters can reduce the emission of ultraviolet and infrared radiation. Use of the ophthalmoscopes at the lowest possible power setting and the shortest possible exposure time would further minimize patient exposure. C1 USA,ENVIRONM HYG AGCY,ABERDEEN PROVING GROUND,MD 21010. RP MILLER, SA (reprint author), US FDA,CTR DEVICES & RADIOL HLTH,ROCKVILLE,MD 20857, USA. NR 20 TC 5 Z9 5 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD APR 1 PY 1992 VL 31 IS 10 BP 1631 EP 1637 PG 7 WC Optics SC Optics GA HM110 UT WOS:A1992HM11000034 PM 20720798 ER PT J AU EASTES, JW AF EASTES, JW TI SPECTRAL AND PHYSICAL-PROPERTIES OF SOME DESERT SOILS - IMPLICATIONS FOR REMOTE SPECTROSCOPIC TERRAIN ANALYSIS IN ARID REGIONS SO APPLIED SPECTROSCOPY LA English DT Article DE REMOTE INFRARED SPECTROSCOPY; TERRAIN ANALYSIS; DESERT SOILS ID REFLECTANCE AB Spectral structure between 2.5 and 13.5-mu-m of a variety of soils collected from the U.S. Southwest and Saudi Arabia is shown to provide qualitative information about composition and texture. Calcite and gypsum, soil components playing significant roles in determining surface hardness, exhibit diagnostic features between 3 and 5-mu-m which may permit their identification via remote sensing. Gypsum also exhibits high surface reflectance at 8.7-mu-m; however this feature would be unreliable in a natural setting because it falls in the same spectral region in which quartz displays its strong fundamental. Silicate reflectance between 8 and 12-mu-m decreases with particle size; thus inferences of soil particle size and texture can potentially be made from spectral data in this region. Such information can be of military importance for forecasting regional vehicle trafficability and dust potential, often crucial concerns in the planning and conduction of tactical field operations. RP EASTES, JW (reprint author), USA,CTR TOPOG ENGN,FT BELVOIR,VA 22060, USA. NR 17 TC 2 Z9 2 U1 1 U2 3 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 201B BROADWAY ST, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD APR PY 1992 VL 46 IS 4 BP 640 EP 644 DI 10.1366/0003702924124934 PG 5 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA HP473 UT WOS:A1992HP47300018 ER PT J AU ZIESKE, LA AF ZIESKE, LA TI PASSIVE EXPOSURE OF COCAINE IN MEDICAL PERSONNEL AND ITS RELATIONSHIP TO DRUG SCREENING-TESTS SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material RP ZIESKE, LA (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD APR PY 1992 VL 118 IS 4 BP 364 EP 364 PG 1 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA HN299 UT WOS:A1992HN29900002 ER PT J AU BROWN, DM BARTON, BR YOUNG, VL PRUITT, BA AF BROWN, DM BARTON, BR YOUNG, VL PRUITT, BA TI DECREASED WOUND CONTRACTION WITH FIBRIN GLUE TREATED SKIN-GRAFTS SO ARCHIVES OF SURGERY LA English DT Article ID ADHESION; SEAL; SURGERY AB Skin grafts can be used effectively to inhibit wound contraction. A critical element of this inhibition is the adherence of the graft to the wound bed. Fibrin glue has been shown to increase the adherence of skin grafts to wound beds. We therefore devised an experiment to determine the effect of fibrin glue on skin graft inhibition of wound contraction. Two 2.5 x 2.5-cm full-thickness defects were created on the dorsa of 15 Sprague-Dawley rats. Thirty partial-thickness grafts were harvested from isogeneric donor animals using a brown dermatome. Prior to grafting, one full-thickness defect, each animal received 0.2 mL of fibrin glue (Immuno AG, Vienna, Austria). The adjacent wound served as the control and received 0.2 mL of normal saline. Grafts were applied, sutured, and protected with an occlusive dressing. The size of graft sites treated with fibrin glue or normal saline was determined at the time of graft application and thereafter at 3-day intervals for 21 days using standardized photographic techniques. The percentage of change from initial wound size at each point was recorded for each group. Graft sites treated with fibrin glue contracted less than the controls from the ninth postgraft day to the completion of the study. The mechanism by which fibrin glue inhibits wound contraction may be related to increased adherence of grafts to the underlying wound bed. As an adjunct in skin grafting, fibrin glue may offer certain advantages that are not achieved by suturing alone. C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. WASHINGTON UNIV,SCH MED,DIV PLAST SURG,ST LOUIS,MO 63110. NR 35 TC 31 Z9 32 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD APR PY 1992 VL 127 IS 4 BP 404 EP 406 PG 3 WC Surgery SC Surgery GA HM464 UT WOS:A1992HM46400006 PM 1558491 ER PT J AU WANG, YS MILLER, DR ANDERSON, DE CIONCO, RM LIN, JD AF WANG, YS MILLER, DR ANDERSON, DE CIONCO, RM LIN, JD TI A SPATIAL LENGTH SCALE ANALYSIS OF TURBULENT TEMPERATURE AND VELOCITY FLUCTUATIONS WITHIN AND ABOVE AN ORCHARD CANOPY SO BOUNDARY-LAYER METEOROLOGY LA English DT Article ID ATMOSPHERIC SURFACE-LAYER; PARTICLE TRAJECTORIES; FOREST CANOPY; AIR-FLOW; NUMERICAL-SIMULATION; VEGETATION CANOPIES; LATERAL COHERENCE; DECIDUOUS FOREST; PLANT CANOPIES; CLOSURE-MODEL AB Turbulent flow within and above an almond orchard was measured with three-dimensional wind sensors and fine-wire thermocouple sensors arranged in a horizontal array. The data showed organized turbulent structures as indicated by coherent asymmetric ramp patterns in the time series traces across the sensor array. Space-time correlation analysis indicated that velocity and temperature fluctuations were significantly correlated over a transverse distance more than 4 m. Integral length scales of velocity and temperature fluctuations were substantially greater in unstable conditions than those in stable conditions. The coherence spectral analysis indicated that Davenport's geometric similarity hypothesis was satisfied in the lower frequency region. From the geometric similarity hypothesis, the spatial extents of large ramp structures were also estimated with the coherence functions. C1 USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. UNIV CONNECTICUT,DEPT CIVIL ENGN,STORRS,CT 06269. RP WANG, YS (reprint author), UNIV CONNECTICUT,DEPT NAT RESOURCES MANAGEMENT & ENGN,STORRS,CT 06269, USA. NR 48 TC 9 Z9 9 U1 0 U2 3 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0006-8314 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD APR PY 1992 VL 59 IS 1-2 BP 125 EP 139 DI 10.1007/BF00120690 PG 15 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA HT785 UT WOS:A1992HT78500007 ER PT J AU JAMES, WF TAYLOR, WD BARKO, JW AF JAMES, WF TAYLOR, WD BARKO, JW TI PRODUCTION AND VERTICAL MIGRATION OF CERATIUM-HIRUNDINELLA IN RELATION TO PHOSPHORUS AVAILABILITY IN EAU-GALLE RESERVOIR, WISCONSIN SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES LA English DT Article ID ALKALINE-PHOSPHATASE ACTIVITY; NORTH-TEMPERATE RESERVOIR; PLANKTONIC DINOFLAGELLATE; EPILIMNETIC PHOSPHORUS; DISTRIBUTION PATTERNS; EDDY DIFFUSION; SHAGAWA LAKE; PHYTOPLANKTON; MINNESOTA; GROWTH AB Seasonal production of Ceratium hirundinella and its diel migratory patterns were examined in relation to phosphorus (P) availability in eutrophic Eau Galle Reservoir, Wisconsin (USA). During mid-June, hypolimnetic P gradients (0.030-1.045 mg.L-1) developed as internal P loading was high (14.7-18.0 mg.m-2.d-1). Ceratium migrated as much as 4 m into the upper hypolimnion at night. Subsequent increases in Ceratium biomass, gross primary productivity, and chlorophyll a indicated retrieval of hypolimnetic P for production. During early July, anoxia restricted vertical migration of Ceratium into the hypolimnion. Surplus cellular P was low during this period, while alkaline phosphatase activity increased to a maximum, suggesting P limitation of Ceratium production. During late July and August, P-rich interflows from the Eau Galle River entered the reservoir at the base of the epilimnion. Ceratium migrated into these interflows at night, with corresponding increases and decreases in surplus cellular P and alkaline phosphatase activity, respectively. Ceratium production increased to a maximum in early September, following these periods of high external P input. These results directly support the hypothesis that Ceratium can access multiple P sources through vertical migration. C1 ENVIRONM LAB,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP JAMES, WF (reprint author), EAU GALLE LIMNOL LAB,WATERWAYS EXPT STN,SPRING VALLEY,WI 54767, USA. NR 40 TC 25 Z9 26 U1 1 U2 7 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0706-652X J9 CAN J FISH AQUAT SCI JI Can. J. Fish. Aquat. Sci. PD APR PY 1992 VL 49 IS 4 BP 694 EP 700 DI 10.1139/f92-078 PG 7 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA HL305 UT WOS:A1992HL30500007 ER PT J AU BALL, DH WILEY, BJ REESE, ET AF BALL, DH WILEY, BJ REESE, ET TI EFFECT OF SUBSTITUTION AT C-6 ON THE SUSCEPTIBILITY OF PULLULAN TO PULLULANASES - ENZYMATIC DEGRADATION OF MODIFIED PULLULANS SO CANADIAN JOURNAL OF MICROBIOLOGY LA English DT Article DE 3,6-ANHYDROPULLULAN; 6-AZIDO-6-DEOXYPULLULAN; BIODEGRADABILITY; 6-CHLORO-6-DEOXYPULLULAN; PULLULAN; PULLULANASES AB Pullulan, with all of the primary hydroxyl groups modified, is an excellent substrate for defining the effect of degree of substitution on biodegradability because of the uniform distribution of substituents on the polysaccharide. 6-Chloro-6-deoxypullulan and 3,6-anhydropullulan are highly resistant to hydrolysis by the four different types of pullulanase. 6-Azido-6-deoxypullulan is resistant to three types but susceptible to hydrolysis by the fourth, isopullulanase. Neopullulanase is strongly inhibited by 6-chloro-6-deoxypullulan and 6-azido-6-deoxypullulan, the other pullulanases much less so. RP BALL, DH (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 17 TC 5 Z9 5 U1 0 U2 1 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4166 J9 CAN J MICROBIOL JI Can. J. Microbiol. PD APR PY 1992 VL 38 IS 4 BP 324 EP 327 PG 4 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology; Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology; Microbiology GA HV212 UT WOS:A1992HV21200010 PM 1611558 ER PT J AU FONTANELLA, JF FONTANELLA, SK AF FONTANELLA, JF FONTANELLA, SK TI ATLAS OF COMMUNISM - STERN,G SO CARTOGRAPHY AND GEOGRAPHIC INFORMATION SYSTEMS LA English DT Book Review RP FONTANELLA, JF (reprint author), US MIL ACAD,DEPT GEOG & ENVIRONM ENGN,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER CONGR SURVEYING & MAPPING PI BETHESDA PA 5410 GROSVENOR LANE, BETHESDA, MD 20814 SN 1050-9844 J9 CARTOGR GEOGR INFORM PD APR PY 1992 VL 19 IS 2 BP 106 EP 107 PG 2 WC Geography SC Geography GA HT347 UT WOS:A1992HT34700010 ER PT J AU MARTIN, TW MOODY, JM BIRD, JJ SLIFE, D MURGO, JP AF MARTIN, TW MOODY, JM BIRD, JJ SLIFE, D MURGO, JP TI EFFECT OF EXERCISE ON INDEXES OF VALVULAR AORTIC-STENOSIS SO CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS LA English DT Article DE CATHETERIZATION; HEMODYNAMICS ID ORIFICE AREA; GORLIN FORMULA AB Changes in the physiologic state of the patient may affect indices of valvular aortic stenosis. We determined the effects of supine exercise on the Gorlin valve area, Cannon valve area, aortic valve resistance, and a modified stroke work loss index in 80 patients with aortic stenosis. Exercise caused a significant increase in the Gorlin and Cannon valve area, while work loss and valve resistance decreased significantly. The average percent change in work loss, 12.2%, was lower than the other indices (P < 0.02), i.e., 15.3% for valve resistance, 18.6% for the Gorlin area, and 19.3% for the Cannon area. The correlation between the rest and exercise measurements was highest for work loss (r = 0.94), compared to 0.93, 0.88, and 0.89 for the other 3 indices, respectively. In patients with a Gorlin area below 1 cm2, exercise caused a significant decrease in work loss, but not Cannon area or valve resistance. However, the percent change was significantly lower and the correlation was better with the work loss index. We conclude that the work loss index is less affected by supine exercise than other indices of aortic stenosis. C1 BROOKE ARMY MED CTR,CARDIOL SERV,FT SAM HOUSTON,TX 78234. NR 17 TC 20 Z9 20 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-6569 J9 CATHETER CARDIO DIAG JI Catheter. Cardiovasc. Diagn. PD APR PY 1992 VL 25 IS 4 BP 265 EP 271 DI 10.1002/ccd.1810250402 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA HK938 UT WOS:A1992HK93800001 PM 1571986 ER PT J AU COWAN, FM BROOMFIELD, CA SMITH, WJ AF COWAN, FM BROOMFIELD, CA SMITH, WJ TI INHIBITION OF SULFUR MUSTARD-INCREASED PROTEASE ACTIVITY BY NIACINAMIDE, N-ACETYL-L-CYSTEINE OR DEXAMETHASONE SO CELL BIOLOGY AND TOXICOLOGY LA English DT Article DE SULFUR MUSTARD; PROTEASE; LYMPHOCYTES AB The pathologic mechanisms underlying sulfur mustard-induced skin vesication remain undefined. Papirmeister et al. (1985) have postulated a biochemical mechanism for sulfur mustard-induced cutaneous injury involving DNA alkylation, metabolic disruption, and enhanced proteolytic activity. We have previously utilized a chromogenic peptide substrate assay to establish that human peripheral blood lymphocytes exposed to sulfur mustard exhibited enhanced proteolytic activity. In this study, compounds known to alter the biochemical events associated with sulfur mustard exposure or to reduce protease activity were tested for their ability to block the sulfur mustard-increased proteolysis. Treatment of cells with niacinamide, N-acetyl-L-cysteine, or dexamethasone resulted in a decrease of sulfur mustard-increased protease activity. Complete inhibition of sulfur mustard-increased proteolysis was achieved by using protease inhibitors (antipain, leupeptin, and 4-(2-aminoethyl)-benzenesulfonylfluoride). These data suggest that therapeutic intervention in the biochemical pathways that culminate in protease activation or direct inhibition of proteolysis might serve as an approach to the treatment of sulfur mustard-induced pathology. C1 USA,BIOCHEM PHARMACOL BRANCH,MED RES INST CHEM DEF,SGRD-UV-PB,ABERDEEN PROVING GROUND,MD 21010. NR 10 TC 19 Z9 21 U1 0 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0742-2091 J9 CELL BIOL TOXICOL JI Cell Biol. Toxicol. PD APR-JUN PY 1992 VL 8 IS 2 BP 129 EP 138 PG 10 WC Cell Biology; Toxicology SC Cell Biology; Toxicology GA JR791 UT WOS:A1992JR79100002 PM 1422923 ER PT J AU HNATIUK, OW DILLARD, TA SCHAEFER, PS MCMANIGLE, J AF HNATIUK, OW DILLARD, TA SCHAEFER, PS MCMANIGLE, J TI BILATERAL HILAR ENLARGEMENT AND DYSPNEA IN A YOUNG BLACK-MAN SO CHEST LA English DT Article ID PULMONARY ARTERIAL-HYPERTENSION; MAGNETIC-RESONANCE; EMBOLI; CT; MEDIASTINUM; INVOLVEMENT; CARCINOMA C1 WALTER REED ARMY MED CTR,DEPT RADIOL,THORAC RADIOL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP HNATIUK, OW (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 20 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD APR PY 1992 VL 101 IS 4 BP 1128 EP 1130 DI 10.1378/chest.101.4.1128 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA HN511 UT WOS:A1992HN51100049 PM 1555431 ER PT J AU TSOKOS, GC AF TSOKOS, GC TI PATHOGENESIS OF HUMAN SYSTEMIC LUPUS-ERYTHEMATOSUS - INTRODUCTION SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Editorial Material C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP TSOKOS, GC (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MED,WASHINGTON,DC 20307, USA. NR 0 TC 4 Z9 4 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD APR PY 1992 VL 63 IS 1 BP 3 EP 3 DI 10.1016/0090-1229(92)90081-X PG 1 WC Immunology; Pathology SC Immunology; Pathology GA HK772 UT WOS:A1992HK77200002 PM 1591879 ER PT J AU TSOKOS, GC AF TSOKOS, GC TI LYMPHOCYTE ABNORMALITIES IN HUMAN LUPUS SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Article ID TYPE-3 COMPLEMENT RECEPTORS; HUMAN-BLOOD LYMPHOCYTES; B-CELL RESPONSES; PERIPHERAL-BLOOD; ERYTHEMATOSUS PATIENTS; ACTIVATED LYMPHOCYTES; IMMUNE-RESPONSES; IMMUNOGLOBULIN; EXPRESSION; SLE C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP TSOKOS, GC (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MED,WASHINGTON,DC 20307, USA. NR 29 TC 22 Z9 22 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD APR PY 1992 VL 63 IS 1 BP 7 EP 9 DI 10.1016/0090-1229(92)90083-Z PG 3 WC Immunology; Pathology SC Immunology; Pathology GA HK772 UT WOS:A1992HK77200004 PM 1591886 ER PT J AU CIESLAK, TJ ROBB, ML DRABICK, CJ FISCHER, GW AF CIESLAK, TJ ROBB, ML DRABICK, CJ FISCHER, GW TI CATHETER-ASSOCIATED SEPSIS CAUSED BY OCHROBACTRUM-ANTHROPI - REPORT OF A CASE AND REVIEW OF RELATED NONFERMENTATIVE BACTERIA SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID CDC GROUP-VD; HUMAN CLINICAL SPECIMENS; ACHROMOBACTER GROUP-B; AGROBACTERIUM-RADIOBACTER; XYLOSOXIDANS BACTEREMIA; VALVE ENDOCARDITIS; ALCALIGENES; IDENTIFICATION; INFECTIONS; MENINGITIS AB Ochrobactrum anthropi, formerly known as CDC group Vd, is an oxidase-producing, gram-negative, non-lactose-fermenting bacillus that oxidizes glucose and grows readily on MacConkey agar. Only occasionally isolated from human clinical specimens, this organism has rarely been found to be pathogenic. We describe the first reported case of infection due to O. anthropi in a child, that of bacteremia in a 3-year-old girl undergoing chemotherapy for retinoblastoma. In addition, we review the literature concerning cases of infection due to this and closely related bacterial species, namely Alcaligenes xylosoxidans subspecies xylosoxidans, Agrobacterium radiobacter, and "Achromobacter" group B. Finally, we attempt to clarify the confusing history and taxonomy of these organisms as well as make recommendations regarding antimicrobial therapy for infections caused by them. C1 WALTER REED ARMY MED CTR,DEPT CLIN MICROBIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. RP CIESLAK, TJ (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,DIV INFECT DIS,BETHESDA,MD 20814, USA. NR 39 TC 77 Z9 78 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR PY 1992 VL 14 IS 4 BP 902 EP 907 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HL304 UT WOS:A1992HL30400016 PM 1576286 ER PT J AU SHANLEY, DJ EVANS, EM BUCKNER, AB DELAPLAIN, CB AF SHANLEY, DJ EVANS, EM BUCKNER, AB DELAPLAIN, CB TI SYNOVIAL OSTEOCHONDROMATOSIS DEMONSTRATED ON BONE-SCAN CORRELATION WITH CT AND MRI SO CLINICAL NUCLEAR MEDICINE LA English DT Note RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,DIV NUCL MED,HONOLULU,HI 96859, USA. NR 3 TC 10 Z9 10 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD APR PY 1992 VL 17 IS 4 BP 338 EP 339 DI 10.1097/00003072-199204000-00021 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA HM775 UT WOS:A1992HM77500021 PM 1572132 ER PT J AU BABCOCK, J SASALA, K CROSS, A DEAL, CD AF BABCOCK, J SASALA, K CROSS, A DEAL, CD TI SIALIDASE IN NEISSERIA-GONORRHOEAE INFECTIONS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A382 EP A382 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74101404 ER PT J AU BHATTACHARJEE, AK OPAL, SM DRABICK, JJ COLLINS, H CROSS, AS AF BHATTACHARJEE, AK OPAL, SM DRABICK, JJ COLLINS, H CROSS, AS TI BOTH IGG AND IGM FRACTIONS OF SERA FROM RABBITS IMMUNIZED WITH BOILED ESCHERICHIA-COLI J5 BACTERIA PROTECT NEUTROPENIC RATS AGAINST LETHAL BACTEREMIA SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. BROWN UNIV,PROVIDENCE,RI 02912. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A382 EP A382 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74101405 ER PT J AU BIRX, DL JOHNSON, S BURKE, DS REDFIELD, RR AF BIRX, DL JOHNSON, S BURKE, DS REDFIELD, RR TI VACCINE THERAPY USING RGP 160 IN EARLY HIV-INFECTION SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,DIV RETROVIROL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A333 EP A333 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74101122 ER PT J AU CROSS, A ARTENSTEIN, A FREDEKING, T QUE, J FURER, E SADOFF, J CRYZ, S AF CROSS, A ARTENSTEIN, A FREDEKING, T QUE, J FURER, E SADOFF, J CRYZ, S TI SAFETY AND IMMUNOGENICITY OF A POLYVALENT ESCHERICHIA-COLI VACCINE IN HUMAN VOLUNTEERS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. SWISS SERUM & VACCINE INST,BERN,SWITZERLAND. ANTIBODY SYST,BEDFORD,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A260 EP A260 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74100710 ER PT J AU DRABICK, J BHATTACHARJEE, A WILLIAMS, W SIBER, G CROSS, A AF DRABICK, J BHATTACHARJEE, A WILLIAMS, W SIBER, G CROSS, A TI COVALENT POLYMYXIN B-STARCH AND POLYMYXIN B-IMMUNOGLOBULIN G CONJUGATES AS NOVEL ANTIENDOTOXIN REAGENTS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. NR 0 TC 5 Z9 5 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A287 EP A287 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74100871 ER PT J AU DRABICK, J BIRXRAYBUCK, D ODAVIA, R REDFIELD, R OSTER, C AF DRABICK, J BIRXRAYBUCK, D ODAVIA, R REDFIELD, R OSTER, C TI CIMETIDINE AS AN IMMUNOAUGMENTING AGENT IN ADVANCED HIV-INFECTION SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT RETROVIROL,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A383 EP A383 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74101408 ER PT J AU KROENKE, K LUCAS, CA ROSENBERG, M SCHEROKMAN, BJ HERBERS, JE WEHRLE, PA BOGGI, JO AF KROENKE, K LUCAS, CA ROSENBERG, M SCHEROKMAN, BJ HERBERS, JE WEHRLE, PA BOGGI, JO TI THE ETIOLOGY OF DIZZINESS - A PROSPECTIVE-STUDY SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A559 EP A559 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74102435 ER PT J AU LANDRY, F PANGARO, L KROENKE, K HERBERS, J LUCEY, C DIEMER, M AF LANDRY, F PANGARO, L KROENKE, K HERBERS, J LUCEY, C DIEMER, M TI A CONTROLLED TRIAL OF A SEMINAR TO IMPROVE MEDICAL-STUDENT ATTITUDES, KNOWLEDGE AND USE OF MEDICAL LITERATURE SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNILEVER FORSCH GESELL MBH,W-2000 HAMBURG 50,GERMANY. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A600 EP A600 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74102682 ER PT J AU LUCEY, CR BLATT, SP BUTZIN, C HENDRIX, CW LUCEY, DR AF LUCEY, CR BLATT, SP BUTZIN, C HENDRIX, CW LUCEY, DR TI TOTAL LYMPHOCYTE COUNT AS A PREDICTOR OF CD4+ T-CELL COUNT IN HIV-INFECTED PERSONS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236. RI Hendrix, Craig/G-4182-2014 OI Hendrix, Craig/0000-0002-5696-8665 NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A560 EP A560 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74102440 ER PT J AU LUCEY, DR NOVAK, J REDFIELD, RR GARTNER, S AF LUCEY, DR NOVAK, J REDFIELD, RR GARTNER, S TI HUMAN MONOCYTE-MACROPHAGES EXPRESS SUBSTANCE-P RECEPTORS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,HENRY M JACKSON FDN,DEPT RETROVIRAL RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A270 EP A270 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74100774 ER PT J AU NATH, J SCHNEIDER, I AF NATH, J SCHNEIDER, I TI ANTIMALARIAL EFFECTS OF THE ANTITUBULIN HERBICIDE TRIFLURALIN - STUDIES IN PLASMODIUM-FALCIPARUM SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT HEMATOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307. NR 0 TC 17 Z9 17 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A331 EP A331 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74101112 ER PT J AU OPAL, SM FISHER, CJ CROSS, AS PALARDY, JE HOOVER, DL MARRA, MN SCOTT, RW AF OPAL, SM FISHER, CJ CROSS, AS PALARDY, JE HOOVER, DL MARRA, MN SCOTT, RW TI BACTERICIDAL PERMEABILITY-INCREASING PROTEIN AS AN ANTIENDOTOXIN THERAPEUTIC AGENT - COMPARISONS WITH ANTI-CORE GLYCOLIPID POLYCLONAL ANTIBODY THERAPY SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 BROWN UNIV,PROVIDENCE,RI 02912. CASE WESTERN RESERVE UNIV,CLEVELAND,OH 44106. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. INCYTE PHARMACEUT,PALO ALTO,CA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A213 EP A213 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74100438 ER PT J AU ROTHWELL, SW WRIGHT, DG AF ROTHWELL, SW WRIGHT, DG TI CHARACTERIZATION OF INFLUENZA-A VIRUS BINDING-SITES ON HUMAN NEUTROPHILS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT HEMATOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A247 EP A247 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74100638 ER PT J AU ROY, MJ HERBERS, J KROENKE, K AF ROY, MJ HERBERS, J KROENKE, K TI WHEN THE DOCTOR LEAVES THE PATIENT - TRANSFER OF CARE IN THE CLINIC SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A617 EP A617 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74102784 ER PT J AU SMITH, KJ WELSH, M SKELTON, HG YEAGER, J AF SMITH, KJ WELSH, M SKELTON, HG YEAGER, J TI HISTOPATHOLOGIC FEATURES AND IMMUNOHISTOCHEMICAL STAINING FOUND IN INFLAMMATORY LINEAR VERRUCOUS EPIDERMAL NEVI SUGGEST A DISTINCTIVE PATTERN OF CLONAL DYSREGULATION OF GROWTH SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A462 EP A462 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74101859 ER PT J AU STEINWEG, DL WORTH, H AF STEINWEG, DL WORTH, H TI ALCOHOLISM SCREENING - A COMPARISON OF 2 DIFFERENT INTRODUCTIONS TO THE CAGE QUESTIONS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV GEN INTERNAL MED,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A619 EP A619 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74102794 ER PT J AU WILLIAMS, W CROSS, A BHATTACHARJEE, A HOOVER, D YOUNG, L DRABICK, J WINSTON, S SADOFF, J AF WILLIAMS, W CROSS, A BHATTACHARJEE, A HOOVER, D YOUNG, L DRABICK, J WINSTON, S SADOFF, J TI INHIBITION OF ENDOTOXIN ACTIVITY IN MICE WITH ANTISERA TO GENTIOBIOSE HEPTAACETATE CONJUGATE VACCINES SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIVAX BIOL,ROCKVILLE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A383 EP A383 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74101411 ER PT J AU YUAN, CM KIANDOLI, L MOORE, J AF YUAN, CM KIANDOLI, L MOORE, J TI PHOSPHORAMIDON INHIBITS ENDOTHELIN PRODUCTION BY ENDOTHELIAL-CELLS EXPOSED TO CYCLOSPORINE SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,NEPHROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1992 VL 40 IS 2 BP A316 EP A316 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HN741 UT WOS:A1992HN74101033 ER PT J AU DUCEY, JP LAMIELL, JM GUELLER, GE AF DUCEY, JP LAMIELL, JM GUELLER, GE TI ARTERIAL-VENOUS CARBON-DIOXIDE TENSION DIFFERENCE DURING SEVERE HEMORRHAGE AND RESUSCITATION SO CRITICAL CARE MEDICINE LA English DT Article DE CARBON DIOXIDE; HEMORRHAGE; RESUSCITATION; SHOCK; ACIDOSIS; HYPOTENSION; SWINE MODEL; BLOOD FLOW; HETASTARCH; BLOOD GAS ANALYSIS ID CARDIOPULMONARY RESUSCITATION; CARDIAC-ARREST; BLOOD; INDICATOR; PCO2 AB Purpose: To define clinically useful markers for determining the adequacy of resuscitation after hemorrhage. Design: Prospective study of 20 Yorkshire swine, using an established model for hemorrhagic shock in swine. Background and Methods: Clinically useful markers for assessing the adequacy of resuscitation after hemorrhage do not exist. We assess variables, such as BP and arterial blood pH. However, these variables do not correlate well with restoration of organ perfusion. In this study, 14 anesthetized swine were hemorrhaged to a mean arterial pressure of < 25 mm Hg. After 30 mins without interventions, each animal was resuscitated with whole blood, hydroxyethyl starch, or normal saline. At baseline and during shock and resuscitation, hemodynamic variables, arterial and mixed venous blood gases, and arterial lactate concentrations were measured to determine which variables correlated most closely with the restoration of blood flow. Results: The correlation between cardiac index and arterial or mixed venous pH and the correlations with arterial lactate values were poor. The correlation between cardiac index and mixed venous hemoglobin saturation also was weak (r2 = .28). Cardiac index correlated best with the arterial-venous Pco2 difference (r2 = .67) and the arterial-venous pH difference (r2 = .38). Using multiple regression, a linear correlation was established between the cardiac index and the arterial-venous pH and Pco2 difference throughout shock and resuscitation (r2 = .91). Conclusion: These findings suggest that the adequacy of resuscitation after hemorrhage can be assessed using paired arterial and mixed venous pH and Pco2 values. RP DUCEY, JP (reprint author), BROOKE ARMY MED CTR,DEPT SURG,DIV CRIT CARE,FT SAM HOUSTON,TX 78234, USA. NR 17 TC 26 Z9 26 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD APR PY 1992 VL 20 IS 4 BP 518 EP 522 DI 10.1097/00003246-199204000-00014 PG 5 WC Critical Care Medicine SC General & Internal Medicine GA HP191 UT WOS:A1992HP19100014 PM 1559366 ER PT J AU KADAKIA, SC WONG, RKH MAYDONOVITCH, CL NELSON, NR HENKIN, RI AF KADAKIA, SC WONG, RKH MAYDONOVITCH, CL NELSON, NR HENKIN, RI TI SERUM AND TISSUE ZINC CONCENTRATIONS IN PATIENTS WITH ENDOSCOPIC ESOPHAGITIS SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE ZINC; ESOPHAGITIS; H2 ANTAGONIST; INTERLEUKIN-1 AND INTERLEUKIN-6 ID CELL-PROLIFERATION; METALLOTHIONEIN; DEFICIENCY; EPITHELIUM; METABOLISM; EPIDERMIS; BARRIER AB Because zinc is an important metabolic requirement for growth and repair of squamous tissue, we questioned whether changes in serum and esophageal tissue zinc were present in patients with reflux esophagitis. To investigate this question, we prospectively studied 49 patients undergoing upper gastrointestinal endoscopy for symptoms of abdominal pain and discomfort; 19 patients were taking H-2 antagonists at the time of the study. Blood was obtained to measure serum zinc concentrations prior to endoscopy and tissue zinc levels were obtained from esophageal biopsies from the distal, middle, and proximal esophagus in patients who were either endoscopically normal or who exhibited endoscopic esophagitis. Serum zinc concentrations were significantly lower in patients with endoscopic esophagitis compared to the endoscopically normal group (77 +/- 3.8-mu-g/dl vs 88 +/- 2.4-mu-g/dl, P < 0.02). Distal esophageal tissue concentrations were significantly higher in patients with endoscopic esophagitis compared to the endoscopically normal group (200 +/- 30-mu-g/liter vs 135 +/- 15-mu-g/liter, P < 0.05); whereas there were no differences between values obtained in the proximal or middle esophagus. Serum and tissue zinc concentrations in patients with esophagitis receiving H-2 antagonists were more similar to values obtained in patients who were endoscopically normal than to patients with endoscopic esophagitis without treatment. This study suggests that in endoscopic esophagitis: (1) greater amounts of zinc are concentrated in the rapidly proliferating distal esophageal epithelium, (2) the serum zinc pool may serve as a major zinc source, and (3) decreasing esophageal mucosal inflammation with H-2 antagonists may decrease zinc loss via the esophageal epithelium. C1 TASTE & SMELL CLIN,CTR MOLEC NUTR & SENSORY DISORDERS,WASHINGTON,DC. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,GASTROENTEROL SERV,WASHINGTON,DC 20307. NR 21 TC 7 Z9 7 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD APR PY 1992 VL 37 IS 4 BP 513 EP 516 DI 10.1007/BF01307572 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA HL971 UT WOS:A1992HL97100007 PM 1348024 ER PT J AU KIRK, J SCHNEIDER, DA AF KIRK, J SCHNEIDER, DA TI PHYSIOLOGICAL AND PERCEPTUAL RESPONSES TO LOAD-CARRYING IN FEMALE SUBJECTS USING INTERNAL AND EXTERNAL FRAME BACKPACKS SO ERGONOMICS LA English DT Article DE INTERNAL AND EXTERNAL FRAME BACKPACKS; LOAD-CARRYING; CARDIORESPIRATORY RESPONSES; PERCEPTUAL RESPONSES ID MODES AB Eleven female subjects (ages 18-33 years) walked on a motor-driven treadmill at 86 m/min for 1 h carrying 33% of their body weight in a backpack. The grade of the treadmill alternated every 15 min between 0 and 3%. Each subject carried an internal frame backpack for one trial and an external frame backpack for another trial on a separate day. The variables measured during the two load-carrying experiments included oxygen consumption (VO2), heart rate (HR), respiratory exchange ratio (R), minute ventilation V(E), and the ratings of perceived exertion for the chest (RPE-chest), shoulders (RPE-shoulders), and legs (RPE-legs). When oxygen uptake measured during load-carrying was expressed as a percentage of VO2max, the average values were 40.1% (63.5% HRmax) at 0% grade and 49.0% (69.6% HRmax) at 3% grade for both backpacks. No significant differences were found between the two packs for any of the metabolic, cardiorespiratory, or perceptual variables measured. Changes in treadmill grade had a significant effect on VO2, HR, and V(E), regardless of the type of pack carried. Minute ventilation was the only physiological response to load-carrying that increased significantly as exercise duration increased. The values for RPE-chest, RPE-shoulders, and RPE-legs were significantly increased by both exercise time and treadmill slope, regardless of the type of pack frame carried. Thus despite relatively constant metabolic responses over time, increased perception of effort could compromise completion of the load-carrying task. It was concluded that differences in backpack frame design were not great enough to produce significant differences in the energy cost or perception of carrying a moderately heavy load on the back. C1 USA,NATICK RES DEV & ENGN CTR,INDIVIDUAL PROTECT DIRECTORATE,NATICK,MA 01760. RP KIRK, J (reprint author), NORTHEASTERN UNIV,DEPT HLTH SPORT & LEISURE STUDIES,HUMAN PERFORMANCE LAB,BOSTON,MA 02115, USA. NR 17 TC 35 Z9 35 U1 0 U2 4 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0014-0139 J9 ERGONOMICS JI Ergonomics PD APR PY 1992 VL 35 IS 4 BP 445 EP 455 DI 10.1080/00140139208967825 PG 11 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA HU531 UT WOS:A1992HU53100007 PM 1597175 ER PT J AU RAO, VB SAUNDERS, NB AF RAO, VB SAUNDERS, NB TI A RAPID POLYMERASE-CHAIN-REACTION-DIRECTED SEQUENCING STRATEGY USING A THERMOSTABLE DNA-POLYMERASE FROM THERMUS-FLAVUS SO GENE LA English DT Article DE PHAGE T4; AUTOMATED SEQUENCING; GENOME MAPPING; CLINICAL DIAGNOSIS; PCR; TUB POLYMERASE ID INVITRO AB We have developed a polymerase chain reaction (PCR)-directed sequencing strategy for rapid sequencing of DNA from crude viral or cell preparations. The basic strategy consists of two phases. In the first phase. the target DNA is amplified by symmetric PCR with low concentrations of deoxyribonucleotide triphosphate (dNTP) and oligodeoxyribonucleotide primers. This results in exponential amplification of DNA in the initial cycles, reaching a plateau by 25 cycles due to limiting concentrations of dNTP and primers. In the second phase, a small aliquot of the PCR mixture is amplified without any purification, by asymmetric PCR in the presence of a 5'-labeled primer and one of the four dideoxyribonucleotide triphosphates. This results in the accumulation of single-stranded DNA products that are terminated at specific points by incorporation of the appropriate dideoxyribonucleotide monophosphate. The products are then analyzed by electrophoresis on a sequencing gel followed by autoradiography. The PCR conditions are optimized to generate sequence ladders of several hundred nucleotides starting from as low as 100 copies of bacteriophage or bacterial genome in one to two days. C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. RP RAO, VB (reprint author), CATHOLIC UNIV AMER,INST BIOMOLEC STUDIES,DEPT BIOL,103 MCCORT WARD HALL,WASHINGTON,DC 20064, USA. NR 10 TC 20 Z9 22 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1119 J9 GENE JI Gene PD APR 1 PY 1992 VL 113 IS 1 BP 17 EP 23 DI 10.1016/0378-1119(92)90665-C PG 7 WC Genetics & Heredity SC Genetics & Heredity GA HQ849 UT WOS:A1992HQ84900003 PM 1563631 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP HSU, FL AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP HSU, FL TI PREPARATIONS AND REACTIONS OF TRIFLUOROMETHYLTHIOCOPPER SO HETEROATOM CHEMISTRY LA English DT Article ID REAGENTS AB Trifluoromethylthiocopper, a versatile reagent for the introduction of the trifluoromethylthio group into organic compounds, has been prepared in a crystalline form. The thiyl radicals, generated in situ from this precursor, cause the cleavage of the S-S bond of di- and trisulfides to give unsymmetrical di- and trisulfides. Unsymmetrical n-butyl trifluoromethyl disulfide is formed by the cleaveage of the C-S bond of n-butyl sulfide. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP MUNAVALLI, S (reprint author), GEOCENTERS INC,FT WASHINGTON,MD 20744, USA. NR 22 TC 29 Z9 29 U1 1 U2 2 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 1042-7163 J9 HETEROATOM CHEM JI Heteroatom Chem. PD APR PY 1992 VL 3 IS 2 BP 189 EP 192 DI 10.1002/hc.520030216 PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA JT810 UT WOS:A1992JT81000015 ER PT J AU ENAND, R KOERNER, G KNUTILLA, T AF ENAND, R KOERNER, G KNUTILLA, T TI INTO THE TRENCHES ... DEPLOYING EXPERT SYSTEMS IN A MILITARY ENVIRONMENT SO IEEE EXPERT-INTELLIGENT SYSTEMS & THEIR APPLICATIONS LA English DT Article C1 USA,CTR AI,HEADQUARTERS DEPT ARMY,WASHINGTON,DC 20310. RP ENAND, R (reprint author), CARNEGIE GRP INC,GOVT DIAGNOST,PPG PL,PITTSBURGH,PA 15222, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 SN 0885-9000 J9 IEEE EXPERT JI IEEE Expert-Intell. Syst. Appl. PD APR PY 1992 VL 7 IS 2 BP 2 EP 3 PG 2 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA HP273 UT WOS:A1992HP27300001 ER PT J AU BINDER, M WADE, WL CYGAN, P JOW, TR MAMMONE, RJ AF BINDER, M WADE, WL CYGAN, P JOW, TR MAMMONE, RJ TI BREAKDOWN VOLTAGES OF COMMERCIAL POLYMER-FILMS FOLLOWING EXPOSURE TO VARIOUS GAS PLASMAS SO IEEE TRANSACTIONS ON ELECTRICAL INSULATION LA English DT Note AB Increased breakdown voltages were observed in thin (8 to 12-mu-m) commercial thermoplastic polymer films after they had been briefly exposed to low temperature, low pressure, gas plasmas. RP BINDER, M (reprint author), USA,ELECTR TECHNOL & DEVICE LAB,DIV POWER SOURCES,LABCOM,FT MONMOUTH,NJ 07703, USA. NR 3 TC 7 Z9 7 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9367 J9 IEEE T ELECTR INSUL PD APR PY 1992 VL 27 IS 2 BP 399 EP 401 DI 10.1109/14.135611 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA HQ444 UT WOS:A1992HQ44400021 ER PT J AU LETTERIE, GS SAKAS, L AF LETTERIE, GS SAKAS, L TI PROXIMAL TUBAL OBSTRUCTION ASSOCIATED WITH TUBAL SCHISTOSOMIASIS SO INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS LA English DT Article DE PROXIMAL TUBAL OBSTRUCTION; SCHISTOSOMIASIS AB The gynecologic consequences of schistosomiasis may range from minimal inflammation of tubal serosa to more intense reactions involving the periadnexal regions. Complete obliteration of the tubal lumen has not been described. We describe a case of proximal tubal obstruction associated with tubal schistosomiasis. C1 TRIPLER ARMY MED CTR,DEPT PATHOL,ANAT PATHOL SERV,HONOLULU,HI 96859. RP LETTERIE, GS (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,REPROD ENDOCRINOL SERV,HONOLULU,HI 96859, USA. NR 8 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0020-7292 J9 INT J GYNECOL OBSTET JI Int. J. Gynecol. Obstet. PD APR PY 1992 VL 37 IS 4 BP 293 EP 296 DI 10.1016/0020-7292(92)90333-E PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA HJ493 UT WOS:A1992HJ49300011 PM 1350547 ER PT J AU HUSS, K SQUIRE, EN CARPENTER, GB SMITH, LJ HUSS, RW SALATA, K SALERNO, M AGOSTINELLI, D HERSHEY, J AF HUSS, K SQUIRE, EN CARPENTER, GB SMITH, LJ HUSS, RW SALATA, K SALERNO, M AGOSTINELLI, D HERSHEY, J TI EFFECTIVE EDUCATION OF ADULTS WITH ASTHMA WHO ARE ALLERGIC TO DUST MITES SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE EDUCATION; COMPUTER; ASTHMA; MITE ALLERGY; ENVIRONMENT; ALLERGEN; HOME VISITS; SYMPTOMATOLOGY; AVOIDANCE; ADHERENCE ID HOUSE DUST; AVOIDANCE; TRIAL; DERMATOPHAGOIDES; MORTALITY; CHILDHOOD; PATIENT AB The effects of supplementary computer instruction in house dust mite-avoidance measures on adherence to implementing measures, on home dust mite-allergen levels, and on symptomatology were investigated in 52 adult patients with mite-associated asthma. Twenty-six patients received conventional instruction (counseling and written instruction) and the other 26 patients received conventional plus 22 minutes of interactive computer-assisted instruction. Instructions were aimed at mite-avoidance measures. Pre- and postinstruction dust samples were collected, and adherence was monitored. All patients kept symptom diaries twice a day. Patients' progress was followed for 12 weeks, and all patients completed the study. Adherence, number of observed and self-reported mite-avoidance measures implemented after visit, was higher for the computer group (p = 0.023). The computer-instructed group achieved significantly lower levels of mite allergen in bedroom carpets (p = 0.004) with mean levels of mite allergen declining from 6.5 +/- 7.6 to 2.2 +/- 4.3-mu-g/gm of dust (two-site monoclonal antibody assays), whereas levels for the conventional-instructed group did not change. Moreover, by study weeks 9 and 10, the computer-instructed group was significantly less symptomatic (p = 0.033). Mean symptom scores for this group decreased from 12.4 to 7.7, compared with 16.4 to 14.3. Conventional instruction supplemented with computer instruction is suggested in mite education. C1 CATHOLIC UNIV AMER,SCH NURSING,WASHINGTON,DC 20064. RP HUSS, K (reprint author), WALTER REED ARMY MED CTR,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20307, USA. NR 25 TC 57 Z9 58 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD APR PY 1992 VL 89 IS 4 BP 836 EP 843 DI 10.1016/0091-6749(92)90439-9 PG 8 WC Allergy; Immunology SC Allergy; Immunology GA HN860 UT WOS:A1992HN86000009 PM 1560167 ER PT J AU TOBER, RL LI, WQ BHATTACHARYA, PK AF TOBER, RL LI, WQ BHATTACHARYA, PK TI DIFFERENTIAL PHOTOCURRENT SPECTROSCOPY - A NOVEL TECHNIQUE FOR SEMICONDUCTOR CHARACTERIZATION SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID PIEZOREFLECTANCE; PHOTOREFLECTANCE AB Differential photocurrent spectra of various InxGa1-xAs diodes demonstrate that modulated photocurrent techniques can easily be used to characterize p-i-n and Schottky diode structures. The spectra were obtained in such a way as to produce a first derivative with respect to either the photon energy or an electric field. A simple model yields an expression for the differential photocurrent spectra in terms of the derivative functional form normally used to fit modulated spectra. Therefore, the sharp spectral features produced with these techniques can be used to determine not only band-gap energies and spectral linewidths but built-in electric fields as well. C1 UNIV MICHIGAN,DEPT ELECT ENGN & COMP SCI,ANN ARBOR,MI 48109. RP TOBER, RL (reprint author), USA,ADELPHI LAB CTR,HARRY DIAMOND LABS,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 12 TC 4 Z9 4 U1 1 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 1 PY 1992 VL 71 IS 7 BP 3506 EP 3509 DI 10.1063/1.350904 PG 4 WC Physics, Applied SC Physics GA HM704 UT WOS:A1992HM70400066 ER PT J AU KSIAZEK, TG ROLLIN, PE JAHRLING, PB JOHNSON, E DALGARD, DW PETERS, CJ AF KSIAZEK, TG ROLLIN, PE JAHRLING, PB JOHNSON, E DALGARD, DW PETERS, CJ TI ENZYME IMMUNOSORBENT-ASSAY FOR EBOLA VIRUS-ANTIGENS IN TISSUES OF INFECTED PRIMATES SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HEMORRHAGIC-FEVER; SOUTHERN SUDAN; NORTHERN ZAIRE; STRAINS; MONKEYS AB A sandwich enzyme immunosorbent assay (EIA) using a mixture of mouse monoclonal antibodies for antigen capture and polyclonal hyperimmune rabbit anti-Ebola virus serum for antigen detection was developed and evaluated on the tissues of monkeys naturally or experimentally infected with strains of Ebola viruses. When compared with virus isolation, the antigen detection EIA was both sensitive and specific: 44 of 45 (97.7%) liver homogenates and 38 of 41 (92.7%) spleen homogenates that were culture positive and tested by both techniques were positive for viral antigen, while 85 of 87 (97.7%) culture-negative liver homogenates and 66 of 66 culture-negative spleen homogenates were found to be antigen negative. The assay, initially developed to detect antigens of prototype African strains of Ebola virus, reliably detected related strains of Ebola virus found during two recent outbreaks of Ebola virus infection among imported, quarantined Macaca fascicularis monkeys in the United States. The assay allows economical and rapid testing of large numbers of tissue specimens. Antigen was found in homogenates of spleen and liver and in serum. C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21702. HAZLETON LABS,VIENNA,VA 22180. NR 13 TC 85 Z9 91 U1 0 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 1992 VL 30 IS 4 BP 947 EP 950 PG 4 WC Microbiology SC Microbiology GA HJ487 UT WOS:A1992HJ48700035 PM 1572982 ER PT J AU MONGAN, P PETERSON, RE CULLING, RD AF MONGAN, P PETERSON, RE CULLING, RD TI PRESSURE MONITORING CAN ACCURATELY POSITION CATHETERS FOR AIR-EMBOLISM ASPIRATION SO JOURNAL OF CLINICAL MONITORING LA English DT Article DE VEINS-CANNULATION; ANESTHESIA-NEUROSURGICAL; COMPLICATIONS-EMBOLISM; AIR; EQUIPMENT-CATHETERS, RIGHT ATRIAL ID CENTRAL VENOUS CATHETERS; ARM VEINS; DOGS; RESUSCITATION; RETRIEVAL AB Venous air embolism is a potentially catastrophic surgical complication. While prevention and early diagnosis represent the cornerstones of management, definitive therapy of a massive air embolus relies on aspiration of the air through an appropriately located multiorifice catheter. Currently, the most common method for accurately positioning a multiorifice catheter in the high right atrium is an intravenous electrocardiogram (IVECG). Because that method is not always technically feasible, we evaluated a right ventricular waveform as a marker for accurate and reliable catheter localization. Twenty patients were prospectively evaluated. After successful insertion of an antecubital introducer sheath, a multiorifice catheter was advanced into the central circulation (5 orifices, one at the distal tip and four 1.0 x 1.5 mm side orifices spaced 0.5 cm apart beginning 1.2 cm from the distal tip). Simultaneous IVECG and pressure waveforms were monitored. After the catheter was advanced into the right ventricle, it was withdrawn until an IVECG P-wave characteristic of the superior vena cava-right atrial junction was observed. The time from cannulation of the basilic vein until obtaining a characteristic IVECG of the superior vena cava-right atrial junction was 6.6 +/- 4.2 minutes (mean +/- SD). The distance between loss of the right ventricular waveform to the appearance of the desired IVECG P-wave configuration was 3.6 +/- 0.35 cm (mean +/- SD). Because the origin of the observed IVECG complex (1.7 cm proximal to the distal orifice) and of the right ventricular waveform are located in two different places, the tip of the catheter was not considered to be in an optimal position for air aspiration. To position the distal orifice to within 1 cm of the superior vena cava-right atrial junction, we withdrew the catheter an additional 0.7 cm. This method can be used, once the final surgical position is obtained, in lieu of IVECG for reconfirming the position of the catheter during the surgical procedure. If IVECG is technically inadequate, any multiorifice catheter can be used and the catheter could be withdrawn 4.3 cm (3.6 +/- 0.7 cm) after exiting the right ventricle and be in a position that has been experimentally documented to be optimal for air aspiration. The method represents a rapid, reliable alternative to IVECG for confirming position of a multiorifice catheter in the high right atrium. RP MONGAN, P (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234, USA. NR 18 TC 4 Z9 4 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0748-1977 J9 J CLIN MONITOR JI J. Clin. Monit. PD APR PY 1992 VL 8 IS 2 BP 121 EP 125 DI 10.1007/BF01617430 PG 5 WC Anesthesiology SC Anesthesiology GA HP095 UT WOS:A1992HP09500005 PM 1583547 ER PT J AU BASKIN, SI HOROWITZ, AM NEALLEY, EW AF BASKIN, SI HOROWITZ, AM NEALLEY, EW TI THE ANTIDOTAL ACTION OF SODIUM-NITRITE AND SODIUM THIOSULFATE AGAINST CYANIDE POISONING SO JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article ID CYTOCHROME-OXIDASE; ANTAGONISM; TOXICITY; NITROPRUSSIDE; PHARMACOKINETICS; METHEMOGLOBIN; INTOXICATION; DOGS; 4-DIMETHYLAMINOPHENOL; PROTECTION AB The combination of sodium thiosulfate and sodium nitrite has been used in the United States since the 1930s as the primary antidote for cyanide intoxication. Although this combination was shown to exhibit much greater efficacy than either ingredient alone, the two compounds could not be used prohylactically because each exhibits a number of side effects. This review discusses the pharmacodynamics, pharmacokinetics, and toxicology of the individual agents, and their combination. C1 PHARMAVENE INC,GAITHERSBURG,MD. RP BASKIN, SI (reprint author), USA,MED RES INST CHEM DEF,BLDG E-3100,ABERDEEN PROVING GROUND,MD 21010, USA. NR 124 TC 83 Z9 83 U1 1 U2 8 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0091-2700 J9 J CLIN PHARMACOL JI J. Clin. Pharmacol. PD APR PY 1992 VL 32 IS 4 BP 368 EP 375 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA HP684 UT WOS:A1992HP68400011 PM 1569239 ER PT J AU BERNARD, RS KAPITZA, H AF BERNARD, RS KAPITZA, H TI HOW TO DISCRETIZE THE PRESSURE-GRADIENT FOR CURVILINEAR MAC GRIDS SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article C1 FORSCHUNGSZENTRUM GEESTHACHT GMBH,W-2054 GEESTHACHT,GERMANY. RP BERNARD, RS (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 10 TC 9 Z9 9 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0021-9991 J9 J COMPUT PHYS JI J. Comput. Phys. PD APR PY 1992 VL 99 IS 2 BP 288 EP 298 DI 10.1016/0021-9991(92)90208-G PG 11 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA HN915 UT WOS:A1992HN91500010 ER PT J AU IWU, MM KLAYMAN, DL AF IWU, MM KLAYMAN, DL TI EVALUATION OF THE INVITRO ANTIMALARIAL ACTIVITY OF PICRALIMA-NITIDA EXTRACTS SO JOURNAL OF ETHNOPHARMACOLOGY LA English DT Article DE PICRALIMA-NITIDA; PLASMODIUM-FALCIPARUM; ANTIMALARIAL ACTIVITY ID PLANTS AB Extracts of Picralima nitida seeds, fruit rind, and stem bark have been investigated in vitro for antimalarial activity. The extracts showed remarkable inhibitory activity against drug resistant clones ef Plasmodium falciparum at doses of 1.23-32-mu-g/ml. The dichloromethane extract of the fruit rind was the most active of the crude extracts, with IC50 values of 1.61-mu-g/ml for the Indochina (W-2), clone and 2.41-mu-g/ml for the Sierra Leone (D-6), clone. An alkaloid fraction obtained from the methanol extract of the stem bark gave an IC50 value of 2.00-mu-g/ml and 1.23-mu-g/ml in the W-2 and D-6 clones, respectively. The result supports the continued ethnomedical exploration of the plant as a potential antimalarial drug. C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 18 TC 18 Z9 18 U1 0 U2 1 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0378-8741 J9 J ETHNOPHARMACOL JI J. Ethnopharmacol. PD APR PY 1992 VL 36 IS 2 BP 133 EP 135 DI 10.1016/0378-8741(92)90012-G PG 3 WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine GA HU996 UT WOS:A1992HU99600005 PM 1608269 ER PT J AU MISER, WF AF MISER, WF TI OUTCOME OF INFANTS BORN WITH NUCHAL CORDS SO JOURNAL OF FAMILY PRACTICE LA English DT Article DE UMBILICAL CORD; LABOR COMPLICATIONS; FETAL DISTRESS ID UMBILICAL-CORD; HEART-RATE; COMPLICATIONS; COMPRESSION; LENGTH AB Background. The effect of a nuchal cord on the outcome of delivery is controversial. The purposes of this study were to investigate the frequency of nuchal cords and determine the effect that nuchal cords have on the neonate. Methods. In a retrospective, case-control study, 706 consecutive infant deliveries in a community hospital were evaluated. Sixteen deliveries that were complicated by the umbilical cord entangled around an extremity or by a prolapsed cord were excluded from further analysis. The study group consisted of the 167 deliveries (23.7%) complicated by a nuchal cord. The remaining 523 deliveries were used as the control group. Results. There were no significant differences found in maternal age, race, parity, prepregnancy weight, or amount of weight gain between the mothers of the infants in the two groups. Fetal bradycardia and variable decelerations in fetal heart rate occurred almost twice as often in the nuchal cord group (18.6% as compared with 9.6%, P < .01). Despite this finding, there was no significant difference in the number of operative deliveries or in Apgar scores at 1 and 5 minutes between the two groups. There were no perinatal deaths associated with nuchal cords. Infants born with nuchal cords weighed less than those in the control group (3345 g compared with 3468 g, P < .01). There were also significantly fewer large-for-gestational-age and macrosomic infants born in the nuchal cord group. Complications such as jaundice, hypoglycemia, sepsis, and respiratory problems were not increased in the postnatal period because of a nuchal cord. Conclusions. This study suggests that nuchal cords are common and are rarely associated with significant morbidity or mortality in neonates. C1 REYNOLDS ARMY COMMUNITY HOSP,FT SILL,OK. RP MISER, WF (reprint author), TRIPLER ARMY MED CTR,HSHK FM,DEPT FAMILY PRACTICE,TRIPLER AMC,HI 96859, USA. RI Miser, William/E-3686-2011 NR 36 TC 23 Z9 24 U1 0 U2 0 PU APPLETON & LANGE PI E NORWALK PA 25 VAN ZANT ST, E NORWALK, CT 06855 SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD APR PY 1992 VL 34 IS 4 BP 441 EP 445 PG 5 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA HN859 UT WOS:A1992HN85900013 PM 1556538 ER PT J AU HOKE, CH VAUGHN, DW NISALAK, A INTRALAWAN, P POOLSUPPASIT, S JONGSAWAS, V TITSYAKORN, U JOHNSON, RT AF HOKE, CH VAUGHN, DW NISALAK, A INTRALAWAN, P POOLSUPPASIT, S JONGSAWAS, V TITSYAKORN, U JOHNSON, RT TI EFFECT OF HIGH-DOSE DEXAMETHASONE ON THE OUTCOME OF ACUTE ENCEPHALITIS DUE TO JAPANESE ENCEPHALITIS-VIRUS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID CHIANGMAI VALLEY; INFECTIONS; THAILAND; TRIAL AB Death due to Japanese encephalitis usually occurs in the first 5 days of hospitalization as a result of deepening coma with respiratory arrest. Death may result from edema-induced increases in intracranial pressure that might be reduced by the administration of steroids. Sixty-five patients presenting in Thailand to four hospitals with a diagnosis of acute Japanese encephalitis were randomized in a double-masked fashion and stratified by initial mental status into a placebo group (saline) or a treatment group (dexamethasone 0.6 mg/kg intravenously as a loading dose followed by 0.2 mg/kg every 6 h for 5 days). Fifty-five of the 65 had confirmed Japanese encephalitis as demonstrated by detection of virus or by Japanese encephalitis virus-specific IgM antibody. Important outcome measures included mortality (24%, treatment group; 27%, control group), days to alert mental status (3.9 vs. 6.2), and neurologic status 3 months after discharge (45% abnormal in each group). No statistically significant benefit of high-dose dexamethasone could be detected. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. BANGKOK CHILDRENS HOSP,BANGKOK,THAILAND. KAMPANGPHET PROV HOSP,KAMPANGPHET,THAILAND. CHIANGRAI PROV HOSP,CHIANGRAI,THAILAND. CHIANGRAI PROV HOSP,CHIANGRAI,THAILAND. UTTARADIT PROV HOSP,UTTARADIT,THAILAND. RP HOKE, CH (reprint author), WALTER REED ARMY MED CTR,DEPT VIRAL DIS,DIV COMMUNICABLE DIS & INFECT DIS,WASHINGTON,DC 20307, USA. NR 23 TC 56 Z9 62 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR PY 1992 VL 165 IS 4 BP 631 EP 637 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HJ642 UT WOS:A1992HJ64200004 PM 1313068 ER PT J AU YAMAMOTO, T ECHEVERRIA, P YOKOTA, T AF YAMAMOTO, T ECHEVERRIA, P YOKOTA, T TI DRUG-RESISTANCE AND ADHERENCE TO HUMAN INTESTINES OF ENTEROAGGREGATIVE ESCHERICHIA-COLI SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID HEP-2 CELLS; ENTEROADHERENT; DIARRHEA; PATTERNS; ASSAY AB Clinical isolates of enteroaggregative Escherichia coli (EAggEC) were tested for their in vitro susceptibilities to 27 antimicrobial agents. Marked drug resistance was observed with sulfamethoxazole, ampicillin, and chloramphenicol in contrast to such antimicrobial agents as cefixime, sparfloxacin, and ciprofloxacin. One of the EAggEC strains carried a plasmid that conferred on its host resistance to ampicillin, tetracycline, sulfamethoxazole, streptomycin, and spectinomycin and an ability to adhere to child ileal villi or HeLa cells in the characteristic aggregative pattern. This plasmid also mediated D-mannose-resistant hemagglutinin production and bacterial clump formation (autoagglutination). The data demonstrate appearance of marked drug resistance and an intestine-adherence and drug-resistance plasmid in the newest category of diarrheagenic E. coli. C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RP YAMAMOTO, T (reprint author), JUNTENDO UNIV,SCH MED,DEPT BACTERIOL,2-1-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN. NR 15 TC 41 Z9 41 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR PY 1992 VL 165 IS 4 BP 744 EP 749 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HJ642 UT WOS:A1992HJ64200024 PM 1552205 ER PT J AU QUEENER, SF DEAN, RA BARTLETT, MS MILHOUS, WK BERMAN, JD ELLIS, WY SMITH, JW AF QUEENER, SF DEAN, RA BARTLETT, MS MILHOUS, WK BERMAN, JD ELLIS, WY SMITH, JW TI EFFICACY OF INTERMITTENT DOSAGE OF 8-AMINOQUINOLINES FOR THERAPY OR PROPHYLAXIS OF PNEUMOCYSTIS PNEUMONIA IN RATS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID CARINII PNEUMONIA; SECONDARY PROPHYLAXIS; CLINDAMYCIN; PRIMAQUINE; AIDS AB Experimental 8-aminoquinolines from Walter Reed Army Institute for Research are effective for prophylaxis or therapy of Pneumocystis carinii pneumonia in rat models. In the present study, primaquine, WR6026, and WR238605 were tested in prophylaxis and treatment models of P. carinii pneumonia to compare the effectiveness of continuous versus intermittent dosing. For treatment of P. carinii pneumonia, the drugs showed detectable effects when given once every 4 days (primaquine and WR6026 at doses > 8 mg/kg; WR238605 at doses > 2 mg/kg). For prophylaxis, WR6026 and WR238605 were effective given alone daily (WR6026 at doses > 0.25 mg/kg; WR238605 at doses > 0.57 mg/kg). WR6026 and WR238605 at 4 mg/kg given once every 4 days for prophylaxis were as effective as daily trimethoprim-sulfamethoxazole. These studies suggest that higher doses of 8-aminoquinolines administered at appropriate intervals may be as effective as continuous dosing for prophylaxis of P. carinii pneumonia. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP QUEENER, SF (reprint author), INDIANA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL,635 BARNHILL DR,INDIANAPOLIS,IN 46202, USA. FU NIAID NIH HHS [AI-25859, AI-72647] NR 15 TC 18 Z9 18 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR PY 1992 VL 165 IS 4 BP 764 EP 768 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HJ642 UT WOS:A1992HJ64200029 PM 1532406 ER PT J AU SMITH, KJ WELSH, M SKELTON, HG YEAGER, J AF SMITH, KJ WELSH, M SKELTON, HG YEAGER, J TI HISTOPATHOLOGIC FEATURES AND IMMUNOHISTOCHEMICAL STAINING FOUND IN INFLAMMATORY LINEAR VERRUCOUS EPIDERMAL NEVI SUGGEST A DISTINCTIVE PATTERN OF CLONAL DYSREGULATION OF GROWTH SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 1992 VL 98 IS 4 BP 607 EP 607 PG 1 WC Dermatology SC Dermatology GA HL846 UT WOS:A1992HL84600605 ER PT J AU ROBERTS, CR MITRA, R HYAMS, K BRODINE, SK LAL, RB AF ROBERTS, CR MITRA, R HYAMS, K BRODINE, SK LAL, RB TI SEROLOGIC DIFFERENTIATION OF HUMAN LYMPHOTROPIC-T VIRUS TYPE-I FROM TYPE-II INFECTION BY SYNTHETIC PEPTIDE IMMUNOASSAYS SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE SELECT-HTLV; SYNTHEIA; POLYMERASE CHAIN REACTION ID HTLV-II AB Synthetic peptide-based serologic assays (Select-HTLV and SynthEIA) that distinguish the closely related human T-cell lymphotropic virus types I (HTLV-I) and II (HTLV-II) were tested blindly for their ability to correctly identify infection caused by either virus type. Of 57 HTLV-I and 38 HTLV-II specimens from individuals whose infections were confirmed by polymerase chain reaction, the Select-HTLV assay categorized 56 (98%) as HTLV-I, 36 (95%) as HTLV-II, and 3 (3%) as nontypeable. Similarly, the SynthEIA assay categorized 54 (95%) as HTLV-I, 29 (76%) as HTLV-II, and 12 (13%) as nontypeable. More importantly, no specimen was wrongly classified by either assay (100% specificity). Further, analysis of serial specimens from six patients also demonstrated concordant results with the PCR findings. Our results suggest that serotyping of HTLV infections can be achieved reliably by these peptide assays, thus the need for technically complex PCR-based HTLV typing, while not eliminated, can be greatly reduced. C1 CTR DIS CONTROL,CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,RETROVIRUS DIS BRANCH,MAIL STOP G19,ATLANTA,GA 30333. WALTER REED ARMY MED CTR,DEPT DIAGNOST RETROVIROL,DIV RETROVIROL,WASHINGTON,DC 20307. SRA TECHNOL INC,ROCKVILLE,MD. USN,MED RES INST,BETHESDA,MD 20814. USN HOSP,DIV INFECT DIS,SAN DIEGO,CA 92134. NR 19 TC 15 Z9 15 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD APR PY 1992 VL 36 IS 4 BP 298 EP 302 DI 10.1002/jmv.1890360412 PG 5 WC Virology SC Virology GA HL082 UT WOS:A1992HL08200011 PM 1578221 ER PT J AU BEAUDRY, WT WAGNER, GW WARD, JR AF BEAUDRY, WT WAGNER, GW WARD, JR TI SOLID-STATE P-31 MAS NMR-STUDY OF THE DISTRIBUTION AND REACTION OF ORGANOPHOSPHORUS ESTERS ADSORBED ON SYNTHETIC RESIN CATALYSTS SO JOURNAL OF MOLECULAR CATALYSIS LA English DT Article ID CHEMICAL-SHIFT TENSORS; ROTATING SOLIDS; PHOSPHATE; HYDROLYSIS; EXCHANGE; CLEAVAGE; POLYCRYSTALLINE; ZEOLITE; PROBES; SITES AB A powder containing sorptive and reactive resins that was developed for the removal and subsequent catalytic degradation of toxic organophosphorus esters is characterized using dimethyl methylphosphonate (DMMP), p-nitrophenyl diphenylphosphate (PNDP), and P-31 MAS NMR. The results for DMMP confirm, spectroscopically, that the adsorbed ester is distributed between the sorptive and reactive resin components. Spectra of the DMMP surface probe adsorbed on the resin are indicative of two different adsorption sites, one possessing a much larger capacity compared with the other. The large-capacity site is identified as the sorptive macroreticular 'porous' region of the resin. The smaller-capacity site seems to be associated with the reactive quaternary ammonium hydroxide functional groups of the ion-exchange resin. At each type of site, adsorbed DMMP exhibits 'liquid-like' isotropic motion; however, the molecules do not appear to be able to rapidly migrate between the sorptive and reactive regions. Variable-temperature P-31 MAS NMR results for DMMP demonstrate that any molecular exchange between these sites must be occurring at a rate of less than 300 s-1, even at 50-degrees-C. PNDP hydrolyzes on the resin powder to yield diphenyl phosphate (DPP) and p-nitrophenoxide. A second P-31 MAS NMR resonance is not observed for PNDP adsorbed at the reactive sites; however, the anionic DPP product appears to be tightly bound by the quaternary amine ion-exchange group, which may block further PNDP hydrolysis at the reactive site. RP BEAUDRY, WT (reprint author), USA,CTR CHEM RES DEV & ENGN,RES DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 34 TC 13 Z9 13 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-5102 J9 J MOL CATAL PD APR PY 1992 VL 73 IS 1 BP 77 EP 90 DI 10.1016/0304-5102(92)80063-M PG 14 WC Chemistry, Physical SC Chemistry GA HZ170 UT WOS:A1992HZ17000010 ER PT J AU JOHNSON, JC LANGHORST, SM LOYALKA, SK VOLKERT, WA KETRING, AR AF JOHNSON, JC LANGHORST, SM LOYALKA, SK VOLKERT, WA KETRING, AR TI CALCULATION OF RADIATION-DOSE AT A BONE-TO-MARROW INTERFACE USING MONTE-CARLO MODELING TECHNIQUES (EGS4) SO JOURNAL OF NUCLEAR MEDICINE LA English DT Article ID SM-153 EDTMP; TRANSPORT AB Radiation dose rate profiles at a bone-to-marrow interface were calculated by simulating a uniform radiation source at the center of the endosteal layer in a long bone. Isotopes (Sm-153, Re-186, and Ho-166) were assumed to assimilate as surface agents and the dose profiles were calculated on a microscopic scale using the Electron-Gamma Shower (EGS4) computer program. We validated our computational model against published dose factors (delta) for uniform volume distributed sources replicating them to an accuracy of better than 95%. The calculated dose distributions illustrate the relative contribution of atomic electrons, beta, and photon fractions. The backscatter contribution to marrow dose increased from 3% to 4% at the source to 6% to 8% at a marrow depth of 100-mu-m. Backscattered dose fraction was not significantly different among the three isotopes. The dose contribution from the three isotopes was remarkably similar at ranges between 25 and 125-mu-m. C1 UNIV MISSOURI,COLUMBIA,MO 65201. DEPT NUCL ENGN,COLUMBIA,MO. VET HOSP,DEPT NUCL MED,COLUMBIA,MO. RP JOHNSON, JC (reprint author), USA,MAT COMMAND,OFF COMMAND SURGEON,AMCSG-R,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 24 TC 19 Z9 19 U1 1 U2 1 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD APR PY 1992 VL 33 IS 4 BP 623 EP 628 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA HM082 UT WOS:A1992HM08200034 PM 1552352 ER PT J AU SCUBA, JR PARRADO, C AF SCUBA, JR PARRADO, C TI PARAPHARYNGEAL HEMORRHAGE SECONDARY TO THROMBOLYTIC THERAPY FOR ACUTE MYOCARDIAL-INFARCTION SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article C1 BROOKE ARMY MED CTR,RADIAT SERV,FT SAM HOUSTON,TX 78234. RP SCUBA, JR (reprint author), BROOKE ARMY MED CTR,ORAL & MAXILLOFACIAL SURG SERV,BEACH PAVIL,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 5 Z9 5 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD APR PY 1992 VL 50 IS 4 BP 413 EP 415 DI 10.1016/0278-2391(92)90410-2 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HL270 UT WOS:A1992HL27000023 PM 1545300 ER PT J AU RENDER, PJ AF RENDER, PJ TI AN IMPRESSION TECHNIQUE TO MAKE A NEW MASTER CAST FOR AN EXISTING REMOVABLE PARTIAL DENTURE SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB When the master cast for a removable partial denture is lost and a well-fitting framework remains, it may be necessary to replace the master cast. A two-step impression procedure is described that combines the altered-cast technique and the use of a modified disposable tray. Finger pressure is maintained on the major connector throughout the making of both impressions, to prevent framework movement and loss of contact with prepared rest seats. RP RENDER, PJ (reprint author), BROOKE ARMY MED CTR,AREA DENT LAB,1005 GORGAS CIRCLE,FT SAM HOUSTON,TX 78234, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1992 VL 67 IS 4 BP 488 EP 490 DI 10.1016/0022-3913(92)90078-O PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HL265 UT WOS:A1992HL26500011 PM 1507131 ER PT J AU HOGANS, WR AGAR, JR AF HOGANS, WR AGAR, JR TI THE BOND STRENGTH OF ELASTOMER TRAY ADHESIVES TO THERMOPLASTIC AND ACRYLIC RESIN TRAY MATERIALS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID IMPRESSION MATERIALS; ACCURACY AB This study evaluated the bond strength of selected impression materials (Permlastic, Express, and Hydrosil) to a thermoplastic custom tray material as a function of drying time of the adhesive after application to a tray material. In addition, bond strengths of a polysulfide impression material to an acrylic resin tray material and to a thermoplastic tray material made directly against wax were evaluated. Bond strengths were obtained directly from values of applied load at failure and important conclusions were drawn. RP HOGANS, WR (reprint author), WALTER REED ARMY MED CTR,HOSP DENT CLIN,DENT ACT,ADV EDUC PROGRAM PROSTHODONT,WASHINGTON,DC 20307, USA. NR 6 TC 7 Z9 7 U1 0 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1992 VL 67 IS 4 BP 541 EP 543 DI 10.1016/0022-3913(92)90087-Q PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HL265 UT WOS:A1992HL26500020 PM 1507140 ER PT J AU SHELLEY, JJ PLUMMER, KD AF SHELLEY, JJ PLUMMER, KD TI REMOVABLE PROSTHODONTIC LABORATORY SURVEY SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID CURRICULUM SURVEY; DENTAL SCHOOLS AB This article presents a brief review of the literature concerning the curriculum deemphasis for removable prosthodontics, especially on the subject of complete dentures. The authors surveyed commercial dental laboratories specializing in removable dental prosthetics in three major Texas cities to determine whether dentists were submitting adequate records and information with their complete denture work authorizations. Results indicate that dentists are requesting services from their laboratories without providing adequate records. C1 USA,DENTAC,REMOVABLE PROSTHODONT SERV,FT HOOD,TX 76544. USA,DENTAL,PERKINS DENT CLIN,FT HOOD,TX 76544. NR 12 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1992 VL 67 IS 4 BP 567 EP 568 DI 10.1016/0022-3913(92)90092-O PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HL265 UT WOS:A1992HL26500025 PM 1507145 ER PT J AU NETTI, CA NAGY, WW AF NETTI, CA NAGY, WW TI A SIMPLIFIED MATRIX FOR MAKING DIRECT CORES SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID COMPOSITE AB This article describes the use of a pharmaceutical gelatin capsule as a matrix for making various posted and nonposted crown substructures. The procedure used for a cast post and core using this matrix is outlined. C1 USA,PROSTHODONT RESIDENCY PROGRAM,FT SAM HOUSTON,TX 78234. RP NETTI, CA (reprint author), USA,DEPT FIXED PROSTHODONT,AREA DENT LAB,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 6 Z9 6 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1992 VL 67 IS 4 BP 569 EP 571 DI 10.1016/0022-3913(92)90093-P PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HL265 UT WOS:A1992HL26500026 PM 1507146 ER PT J AU MERRILL, GA MILLER, D CHIRGWIN, J HOROWITZ, PM AF MERRILL, GA MILLER, D CHIRGWIN, J HOROWITZ, PM TI IMMUNOLOGICAL EVIDENCE FOR A CONFORMATIONAL DIFFERENCE BETWEEN RECOMBINANT BOVINE RHODANESE AND RHODANESE PURIFIED FROM BOVINE LIVER SO JOURNAL OF PROTEIN CHEMISTRY LA English DT Article DE RHODANESE; INDIRECT ELISA; IMMUNOLOGICAL; CONFORMATION; STRUCTURE-FUNCTION; RECOMBINANT ID LINKED IMMUNOSORBENT-ASSAY; MONOCLONAL-ANTIBODIES; ENZYME; COVALENT AB Rhodanese has been utilized as a model enzyme for the study of protein structure-function relationships. The enzyme has recently been cloned and the recombinant enzyme is now available for investigation. However, prior to use in structure-function studies, the recombinant enzyme must be shown to have the same structure and activity as the bovine liver enzyme used in the previous studies. An immunological study of the conformations of these enzyme conformers is described. Three antibodies (two monoclonal and one polyclonal, site-directed antibody) were shown to detect distinct and nonoverlapping epitopes. The epitopes of the monoclonal antirhodanese antibodies (R207 and MAB11) were mapped to the same CNBr digest fragment of the amino terminal domain of rhodanese, and the epitope of the site-directed antibody prepared against the interdomain tether sequence of rhodanese (PAT-T1) was mapped to that region of rhodanese (residues 142-156). The rhodanese conformers were studied by monitoring the accessibility of the epitopes recognized by each antibody in each conformer using an indirect ELISA. None of the antibodies could detect its epitope on the purified liver enzyme. Two of the antibodies (R207 and PAT-TI) could also not detect their epitopes on the recombinant enzyme. However, MAB11 did detect a conformational difference between the natural and recombinant rhodanese conformers, indicating the conformational difference is localized in the first 73 amino acids of rhodanese. This difference presumably reflects the difference in the histories of the two enzymes and may be due to differences in enzyme folding, differences in the purification procedures, and differences in storage conditions-all of which could influence the final conformation of the enzyme. C1 UNIV TEXAS,HLTH SCI CTR,DEPT BIOCHEM,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,DEPT CLIN INVEST,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,CTR DEV & APPLICAT BIOANALYT METHODS,SAN ANTONIO,TX 78284. FU NIGMS NIH HHS [GM25177] NR 19 TC 5 Z9 5 U1 0 U2 1 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0277-8033 J9 J PROTEIN CHEM JI J. Protein Chem. PD APR PY 1992 VL 11 IS 2 BP 193 EP 199 DI 10.1007/BF01025225 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA HX982 UT WOS:A1992HX98200010 PM 1382437 ER PT J AU CERCHIE, P SHIPLEY, B AUST, R WASSON, J REAGO, D AF CERCHIE, P SHIPLEY, B AUST, R WASSON, J REAGO, D TI MANNED SIMULATION RESULTS CONCERNING DESIGN PARAMETERS FOR AN EFFECTIVE OBSTACLE AVOIDANCE SYSTEM (OASYS) SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB Tactical helicopters face unique dangers during nap-of-the-earth (NOE) and contour flight operations. Wires, antennas, and their supporting structures are not reliably detected by the unaided eye or pilot night vision systems. The ability to detect obstacles and provide pilot warnings in time to make a controlled avoidance maneuver will greatly enhance survivability. A study was conducted by McDonnell Douglas Helicopter Company (MDHC) for the U.S. Army Communications and Electronics Command Center for Night Vision and Electro-Optics (C2NVEO), Ft. Belvoir, Virginia, to determine Field of View (FOV), Frame Time (FT), slewing, and stabilization requirements for an effective helicopter Obstacle Avoidance System (OASYS). Four sensor configurations differing in the above parameters were tested at two model ranges (200 meters, or 656.17 ft, and 400 meters, or 1312.34 ft). The results indicate that, for the test condition: 1) a 6 deg vertical x 8 deg horizontal FOV is unacceptable, 2) a 200m model range is insufficient, 3) a FOV as small as 20 deg vertical x 30 deg horizontal can be acceptable provided there is adequate stabilization, FT, and model range, and 4) that a 400m model range is sufficient provided the sensor parameters (FOV, FT, slewing and stabilization) are adequate. C1 MCDONNELL DOUGLAS HELICOPTER CO,TECH STAFF,MESA,AZ. USA,CTR US ARMY COMMUN & ELECTR COMMAND,FT BELVOIR,VA 22060. RP CERCHIE, P (reprint author), MCDONNELL DOUGLAS HELICOPTER CO,SIMULAT STUDIES,MESA,AZ 85205, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 1992 VL 37 IS 2 BP 3 EP 10 PG 8 WC Engineering, Aerospace SC Engineering GA HU567 UT WOS:A1992HU56700001 ER PT J AU EVERETT, RA BARTLETT, FD ELBER, W AF EVERETT, RA BARTLETT, FD ELBER, W TI PROBABILISTIC FATIGUE METHODOLOGY FOR SAFE RETIREMENT LIVES SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB Fleet readiness and flight safety strongly depend on the degree of reliability and maintainability that can be designed into rotorcraft flight critical components. The current U.S. Army fatigue life specification for new rotorcraft is the so-called "six nines" reliability, or a probability of failure of one in a million. This report reviews the progress of a round robin which was established by the American Helicopter Society (AHS) Subcommittee for Fatigue and Damage Tolerance to investigate reliability-based fatigue methodology. The participants in this cooperative effort are the U.S. Army Aviation Systems Command (AVSCOM) and the rotorcraft industry. One phase of the joint activity examined fatigue reliability under uniquely defined conditions for which only one answer was correct. The other phases were set up to learn how the different industry methods in defining fatigue strength affected the mean fatigue life and reliability calculations. Hence, constant amplitude and spectrum fatigue test data were provided so that each participant could perform their standard fatigue life analysis. As a result of this round robin, the probabilistic logic for including both fatigue strength and spectrum loading variability to develop a consistent reliability analysis was established. In this first study, the reliability analysis was limited to the linear cumulative damage approach. However, it is expected that superior fatigue life prediction methods will ultimately be developed through this open AHS forum. To that end, these preliminary results were useful in identifying some topics for additional study. RP EVERETT, RA (reprint author), LANGLEY RES CTR,USA,AVSCOM,AEROSTRUCT DIRECTORATE,DIV STRUCT,HAMPTON,VA, USA. NR 12 TC 4 Z9 4 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 1992 VL 37 IS 2 BP 41 EP 53 PG 13 WC Engineering, Aerospace SC Engineering GA HU567 UT WOS:A1992HU56700005 ER PT J AU EVERETT, RA AF EVERETT, RA TI A COMPARISON OF FATIGUE LIFE PREDICTION METHODOLOGIES FOR ROTORCRAFT SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB Because of the current U.S. Army requirement that all new rotorcraft be designed to a "six nines" reliability on fatigue life, this study was undertaken to assess the accuracy of the current safe life philosophy using the nominal stress Palmgren-Miner linear cumulative damage rule to predict the fatigue life of rotocraft dynamic components. It has been shown in the past that this methodology can predict fatigue lives that differ from test lives by more than two orders of magnitude. A further objective of this work was to compare the accuracy of this methodology to another safe life method called the local strain approach as well as to a method which predicts fatigue life based solely on crack growth data. Spectrum fatigue tests were run on notched (K(T) = 2.42) specimens made of 4340 steel using the Felix/28 variable amplitude spectrum (a shortened form of a standard loading sequence for 'fixed' or semi-rigid helicopter rotors). Two other spectra which resulted from a simple rainflow reconstruction of Felix/28 were also tested. Both linear cumulative damage methods predicted the fatigue lives of the Felix/28 tests fairly well, being slightly on the unconservative side of the test data. The crack growth method, which is based on "small-crack" crack growth data and a crack-closure model, also predicted the fatigue lives very well with the predicted lives being slightly longer than the mean test lives but within the experimental scatter band. The crack growth model was also able to predict the change in test lives produced by the rainflow reconstructed spectra. RP EVERETT, RA (reprint author), LANGLEY RES CTR,USA,AVSCOM,AEROSTRUCT DIRECTORATE,HAMPTON,VA, USA. NR 17 TC 2 Z9 2 U1 0 U2 1 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 1992 VL 37 IS 2 BP 54 EP 60 PG 7 WC Engineering, Aerospace SC Engineering GA HU567 UT WOS:A1992HU56700006 ER PT J AU CRAIN, TW KENNON, WG DESMOND, PM DRESNER, ML SANDBERG, GD AF CRAIN, TW KENNON, WG DESMOND, PM DRESNER, ML SANDBERG, GD TI EXTRAGONADAL YOLK-SAC TUMOR IN A SUPERIOR SCROTAL MASS SO JOURNAL OF UROLOGY LA English DT Article DE NEOPLASMS, EMBRYONAL AND MIXED; TESTICULAR NEOPLASMS, SCROTUM ID GERM-CELL TUMORS; TESTIS TUMORS; SEMINOMA AB We report a case of an extragonadal yolk sac tumor in a superior scrotal mass. Testicular ultrasonography was normal preoperatively and after chemotherapy. Serum alpha-fetoprotein was initially increased to 344.55 ng./ml. (normal 0 to 15) but it returned to normal after surgery and chemotherapy. C1 TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859. RP CRAIN, TW (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,UROL SERV,HONOLULU,HI 96859, USA. RI Desmond, Patricia /D-1966-2014 OI Desmond, Patricia /0000-0002-4803-6323 NR 19 TC 2 Z9 2 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD APR PY 1992 VL 147 IS 4 BP 1087 EP 1088 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA HL662 UT WOS:A1992HL66200033 PM 1552591 ER PT J AU DALGARD, DW HARDY, RJ PEARSON, SL PUCAK, GJ QUANDER, RV ZACK, PM PETERS, CJ JAHRLING, PB AF DALGARD, DW HARDY, RJ PEARSON, SL PUCAK, GJ QUANDER, RV ZACK, PM PETERS, CJ JAHRLING, PB TI COMBINED SIMIAN HEMORRHAGIC-FEVER AND EBOLA VIRUS-INFECTION IN CYNOMOLGUS MONKEYS SO LABORATORY ANIMAL SCIENCE LA English DT Article AB Simian hemorrhagic fever (SHF) virus and a new strain of Ebola virus were isolated concurrently in recently imported cynomolgus monkeys (Macaca fascicularis) being maintained in a quarantine facility. Ebola virus had never been isolated in the U.S. previously and was presumed to be highly pathogenic for humans. A chronology of events including measures taken to address the public health concerns is presented. The clinicopathologic features of the disease were abrupt anorexia, splenomegaly, marked elevations of lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase, with less prominent elevations of blood urea nitrogen, creatinine, and other serum chemistry parameters. Histologically, fibrin deposition, hemorrhage, and necrosis of lymphoid cells and reticular mononuclear phagocytes were present in the spleens of SHF and of Ebola virus-infected animals. Intravascular fibrin thrombi and hemorrhage were also present in the renal medulla and multifocally in the gastrointestinal tract. Necrosis of lymphoid and epithelial cells was occasionally noted in the gastrointestinal tract. The histopathologic findings considered specific for Ebola virus infection include hepatocellular necrosis, necrosis of the zona glomerulosa of the adrenal cortex, and interstitial pneumonia, all of which were generally associated with the presence of 1 to 4-mu-intracytoplasmic amphophilic inclusion bodies. The disease spread within rooms despite discontinuation of all direct contact with animals, and droplet or aerosol transmission was suspected. Antibody to Ebola virus developed in animal handlers but no clinical disease was noted, suggesting a less virulent strain of virus. SHF is recognized as a fulminating fatal pathogen for monkeys and previous experimental Ebola infections in monkeys resulted in rapid death. The disease noted in this outbreak progressed slowly within a room and spread was measured in weeks rather than days. When an animal expressed clinical signs, however, death followed within 2 to 7 days. The typical signs of SHF infection such as epistaxis, subcutaneous hemorrhage, bloody diarrhea, and fever were not prominent features of this outbreak. An explanation for the apparent decrease in virulence for these two notorious pathogens is unclear. C1 HAZLETON RES PROD,RESTON,VA. HAZLETON RES PROD,DENVER,PA. HAZLETONS TEXAS PRIMATE CTR,ALICE,TX. USA,MED RES INST INFECT DIS,F DETRICK,MD. RP DALGARD, DW (reprint author), HAZELTON LABS AMER INC,WASHINGTON,VIENNA,VA 22180, USA. NR 9 TC 68 Z9 72 U1 0 U2 13 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD APR PY 1992 VL 42 IS 2 BP 152 EP 157 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA HR654 UT WOS:A1992HR65400009 PM 1318446 ER PT J AU ROY, MJ WALSH, TJ AF ROY, MJ WALSH, TJ TI HISTOPATHOLOGIC AND IMMUNOHISTOCHEMICAL CHANGES IN GUT-ASSOCIATED LYMPHOID-TISSUES AFTER TREATMENT OF RABBITS WITH DEXAMETHASONE SO LABORATORY INVESTIGATION LA English DT Article DE CORTICOSTEROIDS; MUCOSAL IMMUNITY; M-CELLS; DOME EPITHELIUM ID DOME EPITHELIUM; CORTICOSTEROID ACTION; PEYERS PATCHES; SUBPOPULATIONS; HYDROCORTISONE; LYMPHOCYTES; MECHANISMS; MIGRATION; IGA AB Corticosteroids cause impaired cell-mediated immunity which may encourage development of gastrointestinal and respiratory infections. In order to better understand the effects of corticosteroids on gastrointestinal immunity, immunological and histological changes in gut-associated lymphoid tissues were examined after intravenous administration of dexamethasone to rabbits. In treated animals, lymphoid domes and follicles were considerably reduced in size, and the dome epithelial layer was markedly depleted of M cells and lymphocytes. There were numerous open lesions at the luminal surface of dome epithelium, consistent with necrosis of M cells, and a striking depletion of follicular B cells in treated animals. These immunologic and histologic effects of corticosteroids could have found profound, deleterious effects on mucosal immune responses and host resistance to microbial infections. C1 NCI,PEDIAT BRANCH,INFECT DIS SECT,BLDG 10,RM 13N-240,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DEPT EXPTL PATHOL,WASHINGTON,DC 20307. NR 26 TC 14 Z9 16 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD APR PY 1992 VL 66 IS 4 BP 437 EP 443 PG 7 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA HP263 UT WOS:A1992HP26300005 PM 1583884 ER PT J AU FARAG, IH BUZZELL, GM PHETTEPLACE, G AF FARAG, IH BUZZELL, GM PHETTEPLACE, G TI MICROCOMPUTER ANALYSIS OF SOLID LIQUID-PHASE CHANGE HEAT-TRANSFER SO MATHEMATICAL AND COMPUTER MODELLING LA English DT Article ID ENTHALPY METHOD; FRONT AB The development of a microcomputer based finite element program featuring phase change (melting and freezing) simulation and facilities is outlined. A closed form Galerkin finite element method derived from a delta function formulation of the latent heat discontinuity in the heat capacity versus temperature function is used within phase change elements of the solution domain. Storage reduction data structures are implemented and compared on the basis of overall program execution time. Analytical solutions for melting and freezing are used to verify program accuracy and to explore other simulation parameters such as time step size, mesh density and start-up technique. Several "life like" phase change simulations are compared to the results obtained from other numerical models. C1 UNIV NEW HAMPSHIRE,DEPT MECH ENGN,DURHAM,NH 03824. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP FARAG, IH (reprint author), UNIV NEW HAMPSHIRE,DEPT CHEM ENGN,DURHAM,NH 03824, USA. NR 22 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0895-7177 J9 MATH COMPUT MODEL JI Math. Comput. Model. PD APR PY 1992 VL 16 IS 4 BP 105 EP 113 DI 10.1016/0895-7177(92)90038-M PG 9 WC Computer Science, Interdisciplinary Applications; Computer Science, Software Engineering; Mathematics, Applied SC Computer Science; Mathematics GA HN348 UT WOS:A1992HN34800010 ER PT J AU SINGH, A MOSES, FM SMOAK, BL DEUSTER, PA AF SINGH, A MOSES, FM SMOAK, BL DEUSTER, PA TI PLASMA ZINC UPTAKE FROM A SUPPLEMENT DURING SUBMAXIMAL RUNNING SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE EXERCISE; ZINC ABSORPTION; ORAL ZINC TOLERANCE TEST; ZINC SUPPLEMENT; URINARY ZINC ID TOLERANCE-TEST; EXERCISE; ABSORPTION; METABOLISM; COPPER; WOMEN; BLOOD AB The uptake of zinc (Zn) into the plasma after the ingestion of 25 mg of Zn from multivitamin-mineral supplement was studied in 10 men during running (R) and control (C) conditions; the R was for 2 h at 60-65% of their maximal oxygen uptake. Subjects took the supplement with 200 ml of deionized water before the R or C (0-time). Blood was drawn before the Zn load and every 30 min for 3 h. By 2 h, plasma Zn concentrations had risen to values that were 151 +/- 7% and 149 +/- 5% of (0-time) R and C concentrations, respectively. Furthermore, the average rates of Zn uptake into the plasma did not differ between the R and C (4.4 vs 3.8-mu-mol.l-1.h-1) conditions. Finally, areas under the curve were not different (R: 13.2 +/- 1.8-mu-mol.l-1.3h-1; C: 11.5 +/- 1.5-mu-mol.l-1.3h-1). In summary, submaximal endurance running did not affect plasma Zn uptake and therefore absorption of Zn from a supplement taken just prior to exercise. The effect of chronic exercise on Zn absorption remains to be determined. C1 WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. RP SINGH, A (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MIL MED,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 NR 26 TC 7 Z9 7 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD APR PY 1992 VL 24 IS 4 BP 442 EP 446 PG 5 WC Sport Sciences SC Sport Sciences GA HN931 UT WOS:A1992HN93100009 PM 1560740 ER PT J AU SAWKA, MN YOUNG, AJ PANDOLF, KB DENNIS, RC VALERI, CR AF SAWKA, MN YOUNG, AJ PANDOLF, KB DENNIS, RC VALERI, CR TI ERYTHROCYTE, PLASMA, AND BLOOD-VOLUME OF HEALTHY-YOUNG MEN SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE AEROBIC FITNESS; F-CELL RATIO; HEMATOLOGICAL VOLUMES; LEAN BODY MASS; NORMATIVE DATA; SURFACE AREA; TOTAL BLOOD VOLUME; VASCULAR FLUID VOLUMES ID EXERCISE; MUSCLE AB Insufficient data are readily available concerning the vascular fluid volumes of healthy young men. The primary purpose of this study was to develop a normative database for the erythrocyte volume, plasma volume, and blood volume of healthy young men. The secondary purposes were to relate these vascular fluid volumes to the person's body size and physical fitness level and to develop equations that enable their prediction. Fifty-one male soldiers with a mean age of 22 (range 18-35) yr and with a mean maximal aerobic power of 53 (range 42-65) ml O2.kg-1.min-1 had their lean body mass and vascular fluid volumes measured. Erythrocyte volume was measured by Cr-51, and plasma volume was measured by I-125. The findings concerning the erythrocyte volume, plasma volume, and blood volume of these young men are summarized as follows: 1) these vascular fluid volumes are accurately predicted from several indices of body size; 2) lean body mass is the anthropometric index that is most closely correlated to these vascular fluid volumes; 3) the erythrocyte volumes for a given body surface area are lower, particularly for large individuals, than values previously reported in surveys of undefined populations; 4) aerobic fitness is generally not related to vascular volumes; and 5) F-cell ratio is not related to aerobic fitness. C1 BOSTON UNIV,SCH MED,USN,BLOOD RES LAB,BOSTON,MA 02110. RP SAWKA, MN (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760, USA. NR 34 TC 67 Z9 67 U1 0 U2 5 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD APR PY 1992 VL 24 IS 4 BP 447 EP 453 PG 7 WC Sport Sciences SC Sport Sciences GA HN931 UT WOS:A1992HN93100010 PM 1560741 ER PT J AU KLEIN, TA TADA, MS LIMA, JBP TANG, AT AF KLEIN, TA TADA, MS LIMA, JBP TANG, AT TI INFECTION OF ANOPHELES-DARLINGI FED ON PATIENTS INFECTED WITH PLASMODIUM-VIVAX BEFORE AND DURING TREATMENT WITH CHLOROQUINE PLUS PRIMAQUINE IN COSTA MARQUES, RONDONIA, BRAZIL SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE ANOPHELES-DARLINGI; CHLOROQUINE; PRIMAQUINE ID MOSQUITOS; MALARIA; AREAS AB Five patients with asexual and sexual parasites of Plasmodium vivax were treated orally with 600 mg chloroquine diphosphate (hour 0) followed with 300 mg at 8, 24 and 48 h later. Primaquine phosphate, 15 mg, was administered concurrently at h 0 and at 24 h intervals for 14 days. Anopheles darlingi were fed before the first dose (h -0.5) and 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 36, 48, 60 and 72 h later. Mosquitoes were examined for oocysts on day 8 and for sporozoites on day 15 after infection. Four of the five patients studied were still infective to mosquitoes from 1-5 h after the first dose of chloroquine plus primaquine. One of these and one other patient, who vomited 15 min after the first dose, became inffective again at hours 10 and 12, respectively. Once produced, oocysts in mosquitoes fed on patients before, during and after chloroquine plus primaquine treatment appeared normal and produced sporozoite infected salivary glands. In view of these data, it is concluded that primaquine demonstrated rapid gametocytocidal activity and should be administered concurrently with chloroquine to reduce vivax malaria transmission. C1 USA,MED RES UNIT BRAZIL,APO,MIAMI,FL 34030. UNIV BRASILIA,BR-70910 BRASILIA,DF,BRAZIL. NR 16 TC 3 Z9 7 U1 0 U2 0 PU MEM INST OSWALDO CRUZ PI RIO DE JANEIRO PA SECRETARY CAIXA POSTAL 926, 20001 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD APR-JUN PY 1992 VL 87 IS 2 BP 191 EP 195 PG 5 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA JN567 UT WOS:A1992JN56700004 PM 1308564 ER PT J AU SUNWOO, AJ MORRIS, JW LUCEY, GK AF SUNWOO, AJ MORRIS, JW LUCEY, GK TI THE GROWTH OF CU-SN INTERMETALLICS AT A PRETINNED COPPER-SOLDER INTERFACE SO METALLURGICAL TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID 60SN-40PB SOLDER; JOINTS; CU3SN AB This article reports a comparative study of the formation and growth of intermetallic phases at the interface of Cu wetted with a thick solder joint or a thin, pretinned solder layer. The eta-phase (Cu6Sn5) forms when Cu is wet with eutectic solder at temperatures below 400-degrees-C. The intermetallic layer is essentially unaffected by aging at 70-degrees-C for as long as 13 weeks. On aging a eutectic joint at 170-degrees-C, the eta-phase intermetallic layer thickens and epsilon-phase (Cu3Sn) nucleates at the Cu/intermetallic interface and grows to a thickness comparable to that of the eta-phase, while a Pb-rich boundary layer forms in the solder. The aging behavior of a thin, pretinned eutectic layer is qualitatively different. At 170-degrees-C, the Sn in the eutectic is rapidly consumed to form eta-phase intermetallic, which converts to epsilon-phase. The residual Pb withdraws into isolated islands, and the solderability of the surface deteriorates. When the pretinned layer is Pb-rich (95Pb-5Sn), the Sn in the layer is also rapidly converted into eta-phase, in the form of dendrites penetrating from the intermetallic at the Cu interface and discrete precipitates in the bulk. However, the development of the intermetallic largely ceases when the Sn is consumed; epsilon-phase does not form, and the residual Pb remains as an essentially continuous layer, preserving the solderability of the sample. These observations are interpreted in light of the Cu-Sn and Pb-Sn phase diagrams, the temperature of initial wetting, and the relative diffusivities of Cu and Sn in the solder and intermetallic phases. C1 USA,HARRY DIAMOND LABS,PRODUCIBIL TECHNOL BRANCH,ADELPHI,MD 20783. UNIV CALIF BERKELEY,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720. UNIV CALIF BERKELEY,DEPT MAT SCI & MINERAL ENGN,BERKELEY,CA 94720. RP SUNWOO, AJ (reprint author), UNIV CALIF LAWRENCE LIVERMORE NATL LAB,LIVERMORE,CA 94550, USA. NR 29 TC 140 Z9 142 U1 0 U2 16 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0360-2133 J9 METALL TRANS A PD APR PY 1992 VL 23 IS 4 BP 1323 EP 1332 DI 10.1007/BF02665064 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA HL915 UT WOS:A1992HL91500029 ER PT J AU VICK, JA AF VICK, JA TI MEDICAL STUDIES OF THE POISONOUS LAND AND SEA-SNAKES FOUND IN AND AROUND SAUDI-ARABIA SO MILITARY MEDICINE LA English DT Article AB Studies were carried out to determine the comparative toxicity and pathophysiology of 13 of the more poisonous snakes indigenous to Saudi Arabia. Included were four snakes from the Viperidae family, six from the Elapidae family, and three representative sea snakes from the family Hydrophidae. Anesthetized adult beagle dogs and anesthetized monkeys were used in the study. Vital physiological functions were continuously recorded as were changes in the blood coagulation system and any tissue damage produced by the venom at the site of envenomation. For the intravenous administration of the venom, lyophilized venom was obtained by "milking" each of the live specimens used in the study. Actual envenomation was accomplished by grasping the poisonous reptile and allowing the snake to strike the shaved exposed gluteal muscle of the anesthetized animal. Venom from the snakes of the family Viperidae produced death in an average of 3 hours. The average lethal dose was 1.13 mg/kg. Depression of first and second stage clotting factors was observed with these venoms as well as a decrease in fibrinogen levels and in platelet counts. Findings suggestive of intravascular coagulation were also observed with moderate hemolysis of the formed elements. Some local hemorrhage was seen at the site of envenomation. Venom from the Elapidae family of snakes produced death at an average of 1.7 hours. The average lethal dose was 0.70 mg/kg. Death appeared to be primarily due to respiratory paralysis following blockade at the neuromuscular junction. Only moderate hemolysis was seen with these venoms. No intravascular coagulation or tissue damage was seen. The venom of the family Hydrophidae consistently produced death in less than 30 minutes. No tissue damage was observed, nor were any changes seen in the hematological parameters monitored. Death in these studies appeared to be primarily due to respiratory paralysis; however, the breakdown of muscle tissue was observed. It would appear from these preliminary studies that the area in and around Saudi Arabia does indeed have a number of snakes that could be a danger to humans. RP VICK, JA (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20012, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1992 VL 157 IS 4 BP 159 EP 162 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA HN354 UT WOS:A1992HN35400007 PM 1320221 ER PT J AU VANDERBURGH, PM AF VANDERBURGH, PM TI ABILITY OF THE ARMY CIRCUMFERENCE METHOD TO DETECT CHANGES IN SUBCUTANEOUS FAT OVER A 9-WEEK PERIOD SO MILITARY MEDICINE LA English DT Article AB The Army Circumference Method (ACM), used to estimate percent body fat for soldiers, has been shown to have questionable validity as applied to women. This study's primary purpose was to examine the ability of this method to detect changes in subcutaneous fat over a 9-week period with men (N = 55) and women (N = 51) enrolled in a weight management program. Changes in percent body fat, based on the ACM, were correlated with the corresponding ones from the Jackson/Pollock skinfold method. Results indicated that the male ACM (r2 = 0.548) could more satisfactorily detect changes in subcutaneous fat than the female ACM (r2 = 0.135). RP VANDERBURGH, PM (reprint author), US MIL ACAD,DEPT PHYS EDUC,SPORTS MED BRANCH,W POINT,NY 10996, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1992 VL 157 IS 4 BP 186 EP 188 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA HN354 UT WOS:A1992HN35400014 PM 1620379 ER PT J AU VANDERBURGH, PM AF VANDERBURGH, PM TI FAT DISTRIBUTION - ITS PHYSIOLOGICAL SIGNIFICANCE, HEALTH IMPLICATIONS, AND ITS ADAPTATION TO EXERCISE TRAINING SO MILITARY MEDICINE LA English DT Article AB Recently, fat distribution has become of clinical interest in assessing one's risk for coronary heart disease (CHD). Investigations have shown stronger relationships between abdominal, or central adiposity, and various well known risk factors for CHD, than peripheral and/or total adiposity. The simple waist-to-hip ratio, shown to be a valid index of such fat distribution, should be considered for use by professionals in military medicine in assessing one's risk for relevant diseases. Consideration must also be made of the role of exercise as an intervention in improving one's fat distribution profile. RP VANDERBURGH, PM (reprint author), US MIL ACAD,DEPT PHYS EDUC,SPORTS MED BRANCH,W POINT,NY 10996, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1992 VL 157 IS 4 BP 189 EP 192 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA HN354 UT WOS:A1992HN35400015 PM 1620380 ER PT J AU ALLEN, FW SMITH, BE AF ALLEN, FW SMITH, BE TI IMPACT OF DENTAL SICK CALL ON COMBAT EFFECTIVENESS - THE DENTAL FITNESS CLASS-3 SOLDIER SO MILITARY MEDICINE LA English DT Article AB Dental sick call can have a significant impact on combat effectiveness, a loss of up to 18,720 man days per division per year. This study identified two target populations that interceptive dental treatment could best be directed toward. They are the E-1 to E-3 pay grades and soldiers in combat arms units. This study also offers dental resources needed to treat various target populations. RP ALLEN, FW (reprint author), USA,ADV EDUC PROGRAM GEN DENT 2 YEARS,WASHINGTON,DC 20310, USA. NR 0 TC 11 Z9 16 U1 2 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1992 VL 157 IS 4 BP 200 EP 203 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA HN354 UT WOS:A1992HN35400018 PM 1620383 ER PT J AU WOHLHIETER, J AF WOHLHIETER, J TI WORKSHOP ON THE EPIDEMIOLOGY OF RETROVIRAL INFECTIONS - MILITARY MEDICAL CONSORTIUM FOR APPLIED RETROVIRAL RESEARCH SO MILITARY MEDICINE LA English DT Editorial Material RP WOHLHIETER, J (reprint author), WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1992 VL 157 IS 4 BP 204 EP 207 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA HN354 UT WOS:A1992HN35400019 PM 1320222 ER PT J AU DEFRAITES, RF KRAUSS, MR AF DEFRAITES, RF KRAUSS, MR TI ATTENDANCE AND REFERRAL PATTERNS IN A HEALTH PROMOTION PROGRAM FOR SOLDIERS SO MILITARY MEDICINE LA English DT Article AB We studied referral patterns among 505 active duty Army participants in a health promotion program at Fort Lewis, Washington. Over one-third (35.6%) were referred to health care providers for confirmation of cholesterol or blood pressure screening results. Fifty-two (10.3%) had elevated blood pressure screening measurements, of whom 30% had been previously diagnosed as hypertensive. One hundred forty-six had cholesterol levels greater-than-or-equal-to 200 mg/dl, 22.8% of whom were already aware of hypercholesterolemia. Referral for follow-up was not associated with race, sex, or rank after controlling for age. Screening resulted in a large number of referrals for previously unrecognized abnormalities. RP DEFRAITES, RF (reprint author), WALTER REED ARMY MED CTR,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1992 VL 157 IS 4 BP 214 EP 218 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA HN354 UT WOS:A1992HN35400022 PM 1620386 ER PT J AU NOMIZU, S PERSON, DA SAITO, C LOCKETT, LJ AF NOMIZU, S PERSON, DA SAITO, C LOCKETT, LJ TI A UNIQUE CASE OF REDUCING BODY MYOPATHY SO MUSCLE & NERVE LA English DT Article DE CONGENITAL MYOPATHY; MYOPATHY REDUCING; MITRAL VALVE PROLAPSE; HISTOCHEMICAL; ELECTROMYOGRAPHY AB The clinical, electromyographic, and histologic characteristics of a 17-year-old girl with reducing body myopathy are described. She is, to our knowledge, the oldest reported case and the only patient described with severe mitral valve prolapse and scoliosis. Electromyography demonstrated spontaneous positive sharp waves and fibrillation potentials with many low-amplitude, short, polyphasic motor unit potentials. The right deltoid muscle was chaacterized by focal areas with large fibers associated with increased endomysial connective tissue and "split" fibers. Purple-gray sarcoplasmic masses stained with trichrome were PAS-negative, appeared as "empty" spaces with both ATPase and NADH-TR, and stained darkly with menadione NBT. The features described expand the clinical presentation of this myopathy, and may lead to a better understanding of its etiology. C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PHYS MED,HONOLULU,HI 96859. STRAUB CLIN & HOSP,DEPT PATHOL,HONOLULU,HI 96813. NR 7 TC 6 Z9 6 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0148-639X J9 MUSCLE NERVE JI Muscle Nerve PD APR PY 1992 VL 15 IS 4 BP 463 EP 466 DI 10.1002/mus.880150408 PG 4 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA HJ848 UT WOS:A1992HJ84800007 PM 1314327 ER PT J AU GOODKIN, DE COOKFAIR, D WENDE, K BOURDETTE, D PULLICINO, P SCHEROKMAN, B WHITHAM, R JACOBS, L MUNSCHAUER, F EMRICH, L GRANGER, C HERNDON, R RUDICK, R FISCHER, J SIMON, J SALAZAR, A AF GOODKIN, DE COOKFAIR, D WENDE, K BOURDETTE, D PULLICINO, P SCHEROKMAN, B WHITHAM, R JACOBS, L MUNSCHAUER, F EMRICH, L GRANGER, C HERNDON, R RUDICK, R FISCHER, J SIMON, J SALAZAR, A TI INTERRATER AND INTRARATER SCORING AGREEMENT USING GRADES 1.0 TO 3.5 OF THE KURTZKE EXPANDED DISABILITY STATUS SCALE (EDSS) SO NEUROLOGY LA English DT Article ID MULTIPLE-SCLEROSIS; FUNCTIONAL-SYSTEMS; IMPAIRMENT AB We determined inter- and intrarater Kurtzke Expanded Disability Status Scale (EDSS) scoring agreement for four trained examining physicians who evaluated 10 clinically stable multiple sclerosis patients. These patients had previously been determined to have EDSS scores of 1.0 to 3.5 and were scheduled to participate in a funded clinical trial of intramuscular recombinant interferon-beta. Intrarater reliability was greater than interrater reliability for scoring the EDSS and all of its component functional systems scores (FSS). Specifically, individual examiners were able to reproduce three serial examination scores on the same patient on the same day (intrarater agreement) within 1.0 EDSS or 2.0 individual FSS points. Reproducible scoring across examiners (interrater agreement), however, could only be accomplished within 1.5 EDSS or 3.0 individual FSS points. Additionally, the interrater scoring variability in our patients is greater than that previously reported for patients with higher EDSS scores. We conclude that clinical trials that employ the EDSS as an outcome measure of treatment efficacy should include inter- and intrarater agreement data for all examining physicians. Most importantly, studies using a single examining physician to evaluate individual patients throughout the course of a clinical trial will require less change in the EDSS to reliably measure disease activity than will studies using more than one examining physician to evaluate individual patients throughout the trial. C1 SUNY BUFFALO,DEPT SOCIAL & PREVENT MED,DATA MANAGEMENT & STAT OFF,BUFFALO,NY 14260. OREGON HLTH SCI UNIV,DEPT NEUROL,PORTLAND,OR 97201. VET ADM MED CTR,NEUROL SERV,PORTLAND,OR 97207. UNIV COLORADO,DEPT RADIOL,DENVER,CO 80202. WALTER REED ARMY MED CTR,DEPT NEUROL,WASHINGTON,DC 20307. MILLARD FILLMORE HOSP,BAIRD MS CTR,BUFFALO,NY 14209. RP GOODKIN, DE (reprint author), CLEVELAND CLIN EDUC FDN,MELLEN CTR MULTIPLE SCLEROSIS TREATMENT & RES,9500 EUCLID AVE,CLEVELAND,OH 44106, USA. FU NINDS NIH HHS [1R01 NS 26321-01A2] NR 12 TC 144 Z9 144 U1 0 U2 4 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0028-3878 J9 NEUROLOGY JI Neurology PD APR PY 1992 VL 42 IS 4 BP 859 EP 863 PG 5 WC Clinical Neurology SC Neurosciences & Neurology GA HP855 UT WOS:A1992HP85500029 PM 1565242 ER PT J AU SPARENBORG, S BRENNECKE, LH JAAX, NK BRAITMAN, DJ AF SPARENBORG, S BRENNECKE, LH JAAX, NK BRAITMAN, DJ TI DIZOCILPINE (MK-801) ARRESTS STATUS-EPILEPTICUS AND PREVENTS BRAIN-DAMAGE INDUCED BY SOMAN SO NEUROPHARMACOLOGY LA English DT Article DE SEIZURE-RELATED-BRAIN-DAMAGE; ORGANOPHOSPHORUS COMPOUND; CHOLINESTERASE INHIBITION; EXCITOTOXICITY; GUINEA PIG; POWER SPECTRAL ANALYSIS ID ANTICONVULSANT; NEUROPATHOLOGY; NEUROTOXICITY; CONVULSIONS; PATHOLOGY; PROTECTS; SEIZURES; DIAZEPAM; AGENTS; MODEL AB The involvement of the NMDA receptor in the neurotoxicity induced by soman, an organophosphorus compound which irreversibly inhibits cholinesterase, was studied in guinea pigs. The drug MK-801 (0.5, 1 or 5 mg/kg, i.p.) was given as a pretreatment before a convulsant dose of soman or as a posttreatment (30, 100 or 300-mu-g/kg, i.m.) 5 min after the development of soman-induced status epilepticus. Pyridostigmine, atropine and pralidoxime chloride were also given to each subject to counteract the lethality of soman. All subjects that were challenged with soman and given the vehicle for MK-801 (saline) exhibited severe convulsions and electrographic seizure activity. Neuronal necrosis was found in the hippocampus, amygdala, thalamus and the pyriform and cerebral cortices of those subjects surviving for 48 hr. Pretreatment with 0.5 or 1 mg/kg doses of MK-801 did not prevent nor delay the onset of seizure activity but did diminish its intensity and led to its early arrest. At the largest dose (5 mg/kg), MK-801 completely prevented the development of seizure activity and brain damage. Posttreatment with MK-801 prevented, arrested or reduced seizure activity, convulsions and neuronal necrosis in a dose-dependent manner. The NMDA receptor may play a more critical role in the spread and maintenance, rather than the initiation of cholinergically-induced seizure activity. C1 USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,ABERDEEN PROVING GROUND,MD 21010. NR 21 TC 92 Z9 92 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0028-3908 J9 NEUROPHARMACOLOGY JI Neuropharmacology PD APR PY 1992 VL 31 IS 4 BP 357 EP 368 DI 10.1016/0028-3908(92)90068-Z PG 12 WC Neurosciences; Pharmacology & Pharmacy SC Neurosciences & Neurology; Pharmacology & Pharmacy GA HM172 UT WOS:A1992HM17200007 PM 1522953 ER PT J AU SHANLEY, DJ VASSALLO, CJ AF SHANLEY, DJ VASSALLO, CJ TI ATYPICAL PRESENTATION OF LHERMITTE-DUCLOS DISEASE - PREOPERATIVE DIAGNOSIS WITH MRI SO NEURORADIOLOGY LA English DT Article DE CEREBELLUM; DEVELOPMENTAL DISORDER; LHERMITTE-DUCLOS DISEASE; MAGNETIC RESONANCE IMAGING ID DYSPLASTIC GANGLIOCYTOMA; CEREBELLUM AB In a 35-year-old man with clinical features mimicking acute subarachnoid hemorrhage, MRI demonstrated bilateral Lhermitte-Duclos disease. RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 12 TC 14 Z9 14 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0028-3940 J9 NEURORADIOLOGY JI Neuroradiology PD APR PY 1992 VL 34 IS 2 BP 103 EP 104 PG 2 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA HQ052 UT WOS:A1992HQ05200004 PM 1603303 ER PT J AU CAMPBELL, JG JACOBS, AM AF CAMPBELL, JG JACOBS, AM TI DETECTION OF BURIED LAND MINES BY COMPTON BACKSCATTER IMAGING SO NUCLEAR SCIENCE AND ENGINEERING LA English DT Article ID ENERGY-ABSORPTION AB The application of Compton backscatter imaging to the detection of buried nonmetallic land mines is examined. A combination of measurements and calculations is used to address the problem. Measurements are made using an X-ray source, positioning system, and various detectors. A Monte Carlo photon transport code is the primary method used in calculations. An imaging system, based on detector collimation to emphasize differences in the interactions of multiply scattered photons in soil and explosive, is capable of mine detection to depths of at least 7.5 cm. C1 UNIV FLORIDA,DEPT NUCL ENGN SCI,GAINESVILLE,FL 32611. RP CAMPBELL, JG (reprint author), US MIL ACAD,DEPT PHYS,W POINT,NY 10996, USA. NR 27 TC 16 Z9 16 U1 0 U2 0 PU AMER NUCLEAR SOCIETY PI LA GRANGE PK PA 555 N KENSINGTON AVENUE, LA GRANGE PK, IL 60525 SN 0029-5639 J9 NUCL SCI ENG JI Nucl. Sci. Eng. PD APR PY 1992 VL 110 IS 4 BP 417 EP 424 PG 8 WC Nuclear Science & Technology SC Nuclear Science & Technology GA HP316 UT WOS:A1992HP31600011 ER PT J AU POLZIN, WJ KOPELMAN, JN ROBINSON, RD READ, JA BRADY, K AF POLZIN, WJ KOPELMAN, JN ROBINSON, RD READ, JA BRADY, K TI THE ASSOCIATION OF ANTIPHOSPHOLIPID ANTIBODIES WITH PREGNANCIES COMPLICATED BY FETAL GROWTH RESTRICTION - REPLY SO OBSTETRICS AND GYNECOLOGY LA English DT Letter RP POLZIN, WJ (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD APR PY 1992 VL 79 IS 4 BP 637 EP 638 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA HL511 UT WOS:A1992HL51100034 ER PT J AU HEMPHILL, ES EBERT, FR MUENCH, AG AF HEMPHILL, ES EBERT, FR MUENCH, AG TI THE MEDIAL GASTROCNEMIUS-MUSCLE FLAP IN THE TREATMENT OF WOUND COMPLICATIONS FOLLOWING TOTAL KNEE ARTHROPLASTY SO ORTHOPEDICS LA English DT Article C1 DWIGHT D EISENHOWER ARMY MED CTR,ORTHOPED SURG SERV,FT GORDON,GA 30905. NR 9 TC 15 Z9 17 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD APR PY 1992 VL 15 IS 4 BP 477 EP 480 PG 4 WC Orthopedics SC Orthopedics GA HN754 UT WOS:A1992HN75400011 PM 1565583 ER PT J AU CASLER, JD CONLEY, JJ AF CASLER, JD CONLEY, JJ TI SURGICAL-MANAGEMENT OF ADENOID CYSTIC CARCINOMA IN THE PAROTID-GLAND SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID FACIAL-NERVE; HEAD; NECK; SURGERY; ORIGIN AB Although adenoid cystic carcinoma may be found in multiple sites in the head and neck as well as other glandular sites throughout the body, nowhere is management of the disease more controversial than in the parotid gland. Here the facial nerve is at risk from both the disease and the treatment. Seventy-five cases of adenoid cystic carcinoma of the parotid were analyzed. Patients were placed in four groups, depending on the type of parotid surgery received as definitive therapy: (1) lateral lobectomy, (2) total parotidectomy, (3) radical parotidectomy without preoperative facial weakness, and (4) radical parotidectomy with preoperative facial weakness. Patients were assessed with regard to staging of the initial lesion, the status of surgical margins, and the use of postoperative radiotherapy. The incidence of local recurrence and distant metastases were also recorded. Survival statistics are presented for each group. Though associated with facial nerve sacrifice, radical parotidectomy appears to offer clear advantages in terms of long-term disease-free survival in patients with T2 and T3 lesions. The residual facial paralysis may be rehabilitated primarily or secondarily to reduce patient morbidity. Four of 16 patients (25%) with preoperative weakness achieved 10-year survival when radical parotidectomy was used. Obtaining clear margins at the initial setting appears to offer improved survival. C1 ST VINCENTS MED CTR,NEW YORK,NY. COLUMBIA UNIV COLL PHYS & SURG,DEPT OTOLARYNGOL HEAD & NECK SURG,NEW YORK,NY 10032. RP CASLER, JD (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,OTOLARYNGOL HEAD & NECK SURG SERV,WASHINGTON,DC 20307, USA. NR 16 TC 19 Z9 21 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 1992 VL 106 IS 4 BP 332 EP 338 PG 7 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA HP335 UT WOS:A1992HP33500003 PM 1314372 ER PT J AU VIETTI, TJ LAND, V SHUSTER, JJ AMYLON, M LINK, M BERARD, C CRIST, W BOROWITZ, M FALLETTA, J BOWMAN, WP BRECHER, M CASTLEBERRY, R FRANKEL, L GOORIN, A HAYES, FA HVIZDALA, E KRISCHER, JP POLLOCK, BH MCWILLIAMS, N MURPHY, S PICK, T PULLEN, J RAVINDRANATH, Y SMITH, EI STEUBER, CP SULLIVAN, M VANEYS, J WHARAM, M AF VIETTI, TJ LAND, V SHUSTER, JJ AMYLON, M LINK, M BERARD, C CRIST, W BOROWITZ, M FALLETTA, J BOWMAN, WP BRECHER, M CASTLEBERRY, R FRANKEL, L GOORIN, A HAYES, FA HVIZDALA, E KRISCHER, JP POLLOCK, BH MCWILLIAMS, N MURPHY, S PICK, T PULLEN, J RAVINDRANATH, Y SMITH, EI STEUBER, CP SULLIVAN, M VANEYS, J WHARAM, M TI PROGRESS AGAINST CHILDHOOD-CANCER - THE PEDIATRIC ONCOLOGY GROUP EXPERIENCE SO PEDIATRICS LA English DT Article DE CANCER; COOPERATIVE GROUP; NEOPLASM ID ACUTE LYMPHOBLASTIC-LEUKEMIA; CHILDREN AB The sequential outcome was evaluated for all childhood cancers in which the Pediatric Oncology Group has conducted a series of clinical trials, with constant eligibility, on patients with newly diagnosed cancer. The analysis was applied to more than 7000 patients with cancer diagnosed between 1976 and 1989. These include acute leukemia (4 subgroups), non-Hodgkins lymphoma (4 subgroups), osteogenic sarcoma, and advanced neuroblastoma. In 8 of these 10 disease areas, significant improvement in outcome has occurred. In rare diseases such as pediatric cancer, collaborative studies may be the only way to conduct therapeutic trials of sufficient statistical power. A cooperative group has distinct advantages over a series of ad hoc collaborative studies in that it can maintain a unified data base, study its history with minimal confounding effects of changing institutional participants, and develop long-term research relationships among its participants. C1 UNIV FLORIDA, DEPT STAT, GAINESVILLE, FL 32611 USA. CHILDRENS HOSP STANFORD, PALO ALTO, CA 94304 USA. ST JUDE CHILDRENS RES HOSP, MEMPHIS, TN 38101 USA. DUKE UNIV, MED CTR, DURHAM, NC 27710 USA. COOK FT WORTH CHILDRENS MED CTR, FT WORTH, TX USA. NEW YORK STATE DEPT HLTH, ROSWELL PK MEM INST, DIV PEDIAT, BUFFALO, NY 14263 USA. UNIV ALABAMA, CHILDRENS HOSP, BIRMINGHAM, AL USA. SCOTT & WHITE MEM HOSP & CLIN, DEPT PEDIAT, TEMPLE, TX 76501 USA. HARVARD UNIV, SCH MED, DANA FARBER CANC INST, DEPT PEDIAT, BOSTON, MA 02115 USA. BERLEN LABS INC, ALAMEDA, CA USA. UNIV S FLORIDA, MED CTR, DEPT PEDIAT, TAMPA, FL 33620 USA. UNIV FLORIDA, DEPT PEDIAT, GAINESVILLE, FL 32611 USA. EASTERN MAINE MED CTR, DEPT PEDIAT, BANGOR, ME 04401 USA. CHILDRENS MEM HOSP, CHICAGO, IL 60614 USA. BROOKE ARMY MED CTR, DEPT PEDIAT, FT SAM HOUSTON, TX 78234 USA. UNIV MISSISSIPPI, MED CTR, DEPT PEDIAT, JACKSON, MS 39216 USA. WAYNE STATE UNIV, CHILDRENS HOSP MICHIGAN, DETROIT, MI 48202 USA. UNIV TEXAS, SW MED CTR, DEPT SURG, DALLAS, TX 75230 USA. BAYLOR COLL MED, DEPT PEDIAT, HOUSTON, TX 77030 USA. UNIV TEXAS, MD ANDERSON CANC CTR, DEPT PEDIAT, HOUSTON, TX 77025 USA. JOHNS HOPKINS UNIV, DEPT RADIAT ONCOL, BALTIMORE, MD 21218 USA. RP VIETTI, TJ (reprint author), WASHINGTON UNIV, SCH MED,DEPT PEDIAT,POG OPERAT OFF,SUITE 2A, 4949 W PINE BLVD, ST LOUIS, MO 63108 USA. NR 9 TC 30 Z9 30 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD APR PY 1992 VL 89 IS 4 BP 597 EP 600 PG 4 WC Pediatrics SC Pediatrics GA HM251 UT WOS:A1992HM25100004 ER PT J AU STROSCIO, MA KIM, KW IAFRATE, GJ DUTTA, M GRUBIN, HL AF STROSCIO, MA KIM, KW IAFRATE, GJ DUTTA, M GRUBIN, HL TI DRAMATIC REDUCTION IN THE LONGITUDINAL-OPTICAL PHONON EMISSION RATE IN POLAR-SEMICONDUCTOR QUANTUM WIRES SO PHILOSOPHICAL MAGAZINE LETTERS LA English DT Article ID HETEROSTRUCTURES; GROWTH; SCATTERING; ELECTRONS; SYSTEM AB Novel quantum-effect polar-semiconductor structures underlie technologies portending dramatic enhancements in the capability to process information orders of magnitude faster than is possible currently. In many embodiments of these quantum-effect structures, charges are transported in quasi-one-dimensional quantum wires which must support the transport of charges at high mobilities. However, it has recently been demonstrated that the longitudinal-optical (LO) phonons established at quantum-wire interfaces lead to dramatic enhancements in carrier-phonon interactions and concomitant degradation in carrier mobility. This letter demonstrates that phonon modes may be tailored through the judicious use of metal-semiconductor interfaces in such a way as to dramatically reduce unwanted emission of interface LO phonons and, consequently, to lead to the achievement of high quantum-wire mobility. C1 N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. SCI RES ASSOCIATES ING,GLASTONBURY,CT 06033. RP STROSCIO, MA (reprint author), USA,RES OFF,POB 12211,RES TRIANGLE PK,NC 27709, USA. NR 22 TC 17 Z9 17 U1 0 U2 1 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0950-0839 J9 PHIL MAG LETT JI Philos. Mag. Lett. PD APR PY 1992 VL 65 IS 4 BP 173 EP 176 DI 10.1080/09500839208207532 PG 4 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter SC Materials Science; Metallurgy & Metallurgical Engineering; Physics GA HN944 UT WOS:A1992HN94400001 ER PT J AU SINGH, S RAI, J BOWDEN, CM POSTAN, A AF SINGH, S RAI, J BOWDEN, CM POSTAN, A TI INTRINSIC OPTICAL BISTABILITY WITH SQUEEZED VACUUM SO PHYSICAL REVIEW A LA English DT Article ID LOCAL-FIELD CORRECTION; STATES; ATOMS; MODEL AB Intrinsic optical bistability due to dipole-dipole interactions among interacting two-level atoms shows strong phase dependence in the presence of a squeezed vacuum. We show that by varying the relative phase between the squeezed vacuum and the incident field, it is possible to excite the system of two-level atoms from the lower to upper branch of the bistable curve. On this basis, an optical switch that utilizes this phase dependence for intrinsic optical bistability is proposed. RP SINGH, S (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAP SCI DIRECTORATE,AMSMI-RD-WS,REDSTONE ARSENAL,AL 35898, USA. NR 25 TC 47 Z9 48 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD APR 1 PY 1992 VL 45 IS 7 BP 5160 EP 5165 DI 10.1103/PhysRevA.45.5160 PN B PG 6 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA HN476 UT WOS:A1992HN47600042 ER PT J AU BRENNAN, FX BERGER, DF STARZEC, JJ BALKIN, TJ AF BRENNAN, FX BERGER, DF STARZEC, JJ BALKIN, TJ TI PLASMA-GLUCOSE LEVELS AND LEVERPRESS AVOIDANCE VERSUS ESCAPE BEHAVIORS IN RATS SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE PLASMA GLUCOSE; LEVERPRESS AVOIDANCE; ESCAPE; STRESS; COPING BEHAVIORS ID STRESS; CORTICOSTERONE AB The relationship between performance in an avoidance conditioning paradigm and the plasma glucose levels of Sprague-Dawley rats was examined in two experiments. In Experiment 1 we investigated whether glucose levels varied with the animal's relative success at acquiring the avoidance task. Results indicated that animals classified as avoiders (60% avoidance and above) had lower glucose levels than animals classified as escapers (30% avoidance and below). In Experiment 2 we looked at whether glucose levels showed within-subject changes with avoidance acquisition. Results demonstrated that glucose levels showed reductions if an animal learned the avoidance response. Subjects that did not learn the response showed no such reduction. Such results suggest that the physiological response to stress is attenuated by acquisition of successful coping behaviors that exercise control over the onset of aversive events. C1 SUNY COLL CORTLAND,DEPT PSYCHOL,BOX 2000,CORTLAND,NY 13045. UNIV COLORADO,DEPT PSYCHOL,BOULDER,CO 80309. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 15 TC 1 Z9 1 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD APR PY 1992 VL 51 IS 4 BP 723 EP 727 DI 10.1016/0031-9384(92)90108-E PG 5 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA HR331 UT WOS:A1992HR33100009 PM 1594670 ER PT J AU PAP, GM AF PAP, GM TI MEASURING TO AQL INEFFECTIVE SO QUALITY PROGRESS LA English DT Letter RP PAP, GM (reprint author), USA,PICATINNY ARSENAL,PROD ASSURANCE & TEST DIRECTORATE,DIV TECHNOL,DOVER,NJ 07801, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC QUALITY CONTROL-ASQC PI MILWAUKEE PA ASQC MEMBERSHIP MANAGER 611 E. WISCONSIN AVENUE, MILWAUKEE, WI 53202 SN 0033-524X J9 QUAL PROG JI Qual. Prog. PD APR PY 1992 VL 25 IS 4 BP 6 EP & PG 0 WC Engineering, Multidisciplinary; Engineering, Industrial; Management; Operations Research & Management Science SC Engineering; Business & Economics; Operations Research & Management Science GA HM400 UT WOS:A1992HM40000004 ER PT J AU HOWARD, SL LOCKE, RJ SAUSA, RC MIZIOLEK, AW AF HOWARD, SL LOCKE, RJ SAUSA, RC MIZIOLEK, AW TI MASS-SPECTROMETRIC STUDY OF SIMPLE OLEFINIC FLAMES - COMPARISON WITH LASER DIAGNOSTICS OF C2H4/O2/AR FLAMES AT 20-TORR SO RAPID COMMUNICATIONS IN MASS SPECTROMETRY LA English DT Article ID ATOMIC OXYGEN; FLAT FLAMES; HYDROGEN; FLUORESCENCE; THERMOCOUPLES; SPECTROSCOPY; EXCITATION; NM AB A new research apparatus for characterization of low-pressure premixed flames has been developed. This instrument incorporates several spectral techniques in one apparatus so that various diagnostic techniques can be quantitatively compared and the usable detection range expanded. Features include detection by mass analysis with a triple quadrupole mass spectrometer and by laser techniques such as laser-induced fluorescence. Temperature profiles of the flame both with and without the mass spectrometer probe were obtained by thermocouple. Concentration profiles of the highly reactive flame species H., O, and OH. were obtained and compared. RP HOWARD, SL (reprint author), USA,BALLIST RES LABS,SLCBR-IB-I,ABERDEEN PROVING GROUND,MD 21005, USA. NR 22 TC 4 Z9 4 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0951-4198 J9 RAPID COMMUN MASS SP JI Rapid Commun. Mass Spectrom. PD APR PY 1992 VL 6 IS 4 BP 278 EP 283 DI 10.1002/rcm.1290060411 PG 6 WC Chemistry, Analytical; Spectroscopy SC Chemistry; Spectroscopy GA HN448 UT WOS:A1992HN44800010 ER PT J AU HUGHJONES, M BARRE, N NELSON, G WEHNES, K WARNER, J GARVIN, J GARRIS, G AF HUGHJONES, M BARRE, N NELSON, G WEHNES, K WARNER, J GARVIN, J GARRIS, G TI LANDSAT-TM IDENTIFICATION OF AMBLYOMMA-VARIEGATUM (ACARI, IXODIDAE) HABITATS IN GUADELOUPE SO REMOTE SENSING OF ENVIRONMENT LA English DT Article ID VEGETATION; IXODOIDEA; ECOLOGY; VECTORS AB The objective of this study in 1986-1987 was to determine whether it was possible to remotely identify the specific habitat or habitats of the African bont tick, Amblyomma variegatum, using Landsat-TM imagery data. An unsupervised classification of the April 1986 image was carried out using LAS KMEANS and SPCSRT. The predictability of the landcover classes was determined by visiting random preselected sites within wetlands, woodlands, canefields, and grazing. On a second visit adult ticks were counted in over 103 herds and the habitats recorded. Descriminant analysis indicated that there were a limited number of tick habitats. The tick counts for the herds within these habitats indicate that each habitat probably has a characteristic tick density. The visible farms in Grande Terre, representing four habitats, were then compared with the landcover classes found in a 5 x 5 pixel array at each farm site in the classified image. The habitats could be separated using principal component analysis. Divisive clustering analysis was applied to the band values and derived indices for a similar sized array for each farm site visible in the original unclassified image of Guadeloupe. This analysis clustered the sites by large and small variance of band values, and by vegetation and moisture indices. Herds in heterogeneous sites with large variances had more ticks than those in homogeneous or low variance sites. Within the heterogeneous sites, those with high vegetation and moisture indices had more ticks than those with low values. C1 CTR RECH ANTILLES & GUYANE,INST ELEVAGE & MED VET PAYS TROP MISSION,TICK RES UNIT,POINTE A PITRE,GUADELOUPE. USA,MED RES INST INFECT DIS,DIV DATA PROC,FREDERICK,MD 21701. NASA,GODDARD SPACE FLIGHT CTR,GREENBELT,MD 20771. USDA ARS,US LIVESTOCK INSECT LAB,KERRVILLE,TX. RP HUGHJONES, M (reprint author), LOUISIANA STATE UNIV,SCH VET MED,DEPT EPIDEMIOL & COMMUNITY HLTH,BATON ROUGE,LA 70803, USA. NR 23 TC 25 Z9 25 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0034-4257 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD APR PY 1992 VL 40 IS 1 BP 43 EP 55 DI 10.1016/0034-4257(92)90125-4 PG 13 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA HK758 UT WOS:A1992HK75800004 ER PT J AU KIPP, JW AF KIPP, JW TI SOVIET NAVAL THEORY AND POLICY - GORSHKOV INHERITANCE - HERRICK,TW SO RUSSIAN REVIEW LA English DT Book Review RP KIPP, JW (reprint author), FOREIGN MIL STUDIES OFF,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU OHIO STATE UNIV PRESS PI COLUMBUS PA 1050 CARMACK RD, COLUMBUS, OH 43210 SN 0036-0341 J9 RUSS REV JI Russ. Rev. PD APR PY 1992 VL 51 IS 2 BP 284 EP 285 DI 10.2307/130717 PG 2 WC History SC History GA HM026 UT WOS:A1992HM02600028 ER PT J AU BENEDIKT, RA KRANSDORF, MJ JELINEK, JS MOSER, RP AF BENEDIKT, RA KRANSDORF, MJ JELINEK, JS MOSER, RP TI CASE-REPORT 722 - OSTEOSARCOMATOSIS IN A SKELETALLY IMMATURE GIRL SO SKELETAL RADIOLOGY LA English DT Note ID OSTEO-SARCOMA; BONE-MARROW C1 ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT RADIOL,HERSHEY,PA 17033. NR 10 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-2348 J9 SKELETAL RADIOL JI Skeletal Radiol. PD APR PY 1992 VL 21 IS 3 BP 187 EP 189 PG 3 WC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging SC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging GA HQ585 UT WOS:A1992HQ58500008 PM 1604346 ER PT J AU MORRIS, MJT MCALLISTER, CK AF MORRIS, MJT MCALLISTER, CK TI BACTEREMIA DUE TO PASTEURELLA-MULTOCIDA SO SOUTHERN MEDICAL JOURNAL LA English DT Note ID INFECTIONS RP MORRIS, MJT (reprint author), BROOKE ARMY MED CTR, INFECT DIS SERV, FT SAM HOUSTON, TX 78234 USA. NR 5 TC 15 Z9 15 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD APR PY 1992 VL 85 IS 4 BP 442 EP 443 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA HQ752 UT WOS:A1992HQ75200027 PM 1566154 ER PT J AU VOGEL, JA FRIEDL, KE AF VOGEL, JA FRIEDL, KE TI BODY-FAT ASSESSMENT IN WOMEN - SPECIAL CONSIDERATIONS SO SPORTS MEDICINE LA English DT Review AB Methods of in vivo body fat estimation are based on simple assumptions about body composition which work reasonably well for men, while estimations in women have been largely extrapolated from the male studies so that women are treated as men with just more of the same fat. Compared to men, fat regulation in women is considerably more elaborate, with more and different sites for storage and a larger proportion of fat distributed to the extremities and in subcutaneous locations. Thus, a ratio of waist-to-hips girth which reflects increasing fatness in men only specifies 2 different extremes of a broader spectrum of possibilities for fat distribution in women. This complicates anthropometric prediction of total fatness and clearly limits the generalisability of any female equations. Anthropometric methods are further confounded by difficulties in the criterion methods against which they are developed. For example, the validity of assumptions about the fractional contributions of bone mineral and body water to fat-free mass and density may not hold through the reproductive cycles. Women athletes involved in weight-bearing or strength training may increase bone mineral content above average values but if they become amenorrhoeic, bone mineral density may fall significantly below average values. Fit premenopausal women distribute fat differently and have a higher bone mineral content than unfit postmenopausal women. Genetic factors which also affect criterion method assumptions in men are superimposed on these additional complications in women. Body fat in female athletes extends across almost the entire range of female fatness, with some of the lowest measurements in distance runners and body builders which fall into the normal male range, but also with some relatively high values in swimmers and strength athletes, which would classify these women as obese by male standards. Thus, total body fat reflects a more complex regulation and has a different meaning to health and performance in women than it does for men. Predictive equations for women athletes should be developed with a view to the specific group and ultimate purpose to which they will be applied. RP VOGEL, JA (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT PHYSIOL,OCCUPAT HLTH & PERFORMANCE DIRECTORATE,NATICK,MA 01746, USA. OI Friedl, Karl/0000-0002-3134-8427 NR 0 TC 28 Z9 28 U1 0 U2 6 PU ADIS INTERNATIONAL LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 10, NEW ZEALAND SN 0112-1642 J9 SPORTS MED JI Sports Med. PD APR PY 1992 VL 13 IS 4 BP 245 EP 269 DI 10.2165/00007256-199213040-00003 PG 25 WC Sport Sciences SC Sport Sciences GA HK323 UT WOS:A1992HK32300003 PM 1615253 ER PT J AU CARLSON, DE CIOFFI, WG MASON, AD MCMANUS, WF PRUITT, BA AF CARLSON, DE CIOFFI, WG MASON, AD MCMANUS, WF PRUITT, BA TI RESTING ENERGY-EXPENDITURE IN PATIENTS WITH THERMAL-INJURIES SO SURGERY GYNECOLOGY & OBSTETRICS LA English DT Article ID BURN PATIENTS; REQUIREMENTS AB Resting energy expenditures (REE) were measured using indirect calorimetric techniques in 62 patients with burn injuries admitted during 1987 to 1989 and compared with similar measurements made during 1972 to 1973. Energy requirements were related to burn size in both populations, but were greater in the earlier population. In the present study, data from some patients were obtained using a canopy system and from others during mechanical ventilation and were analyzed separately. The regression of REE on burn size was linear for the canopy measurements (r = 0.724) and for the ventilator measurements (r = 0.579). REE data were corrected for the expected basal metabolic rate (BMR) for each patient, with appropriate adjustment for age and sex. The regression of REE per BMR on burn size was linear (r = 0.724), differing from the curvilinear relationship found during 1972 to 1973. These data suggest a change in postburn energy requirements, probably related to differences in patient management. Predictive equations based on older data can be expected to overestimate energy requirements in patients receiving modern burn therapy. RP CARLSON, DE (reprint author), USA,INST SURG RES,LIB BRANCH,FT SAM HOUSTON,TX 78234, USA. NR 15 TC 37 Z9 37 U1 0 U2 0 PU FRANKLIN H MARTIN FOUNDATION PI CHICAGO PA 55 E ERIE ST, CHICAGO, IL 60611 SN 0039-6087 J9 SURG GYNECOL OBSTET JI Surg. Gynecol. Obstet. PD APR PY 1992 VL 174 IS 4 BP 270 EP 276 PG 7 WC Obstetrics & Gynecology; Surgery SC Obstetrics & Gynecology; Surgery GA HM797 UT WOS:A1992HM79700002 PM 1553604 ER PT J AU JENKINS, TF WALSH, ME AF JENKINS, TF WALSH, ME TI DEVELOPMENT OF FIELD SCREENING METHODS FOR TNT, 2,4-DNT AND RDX IN SOIL SO TALANTA LA English DT Article ID RESIDUES AB Simple field-screening methods are presented for detecting 2,4,6-TNT, 2,4-DNT and RDX in soil. A 20-g portion of soil is extracted by manually shaking with 100 ml of acetone for three minutes. After the soil settles, the supernatant is filtered and divided into three aliquots. Two aliquots are reacted with potassium hydroxide and sodium sulfite to form the red-colored Janowsky complex when 2,4,6-TNT is present or the blue-purple complex when 2,4-DNT is present. The third aliquot of the extract is passed through a strong anion exchange resin to remove nitrate and nitrite. Then the extract is acidified and RDX is reduced with zinc to nitrous acid, which is reacted with a Griess reagent to produce a highly colored azo dye. Concentrations of TNT, 2,4-DNT and RDX are estimated from their absorbances at 540, 570 and 507 nm, respectively. Detection limits are about 1-mu-g/g for 2,4,6-TNT and RDX and about 2-mu-g/g for 2,4-DNT. Concentration estimates from field analyses correlate well with laboratory analyses. RP JENKINS, TF (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 27 TC 88 Z9 88 U1 1 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-9140 J9 TALANTA JI Talanta PD APR PY 1992 VL 39 IS 4 BP 419 EP 428 DI 10.1016/0039-9140(92)80158-A PG 10 WC Chemistry, Analytical SC Chemistry GA HM270 UT WOS:A1992HM27000015 PM 18965397 ER PT J AU MEIER, HL JOHNSON, JB AF MEIER, HL JOHNSON, JB TI THE DETERMINATION AND PREVENTION OF CYTOTOXIC EFFECTS INDUCED IN HUMAN-LYMPHOCYTES BY THE ALKYLATING AGENT 2,2'-DICHLORODIETHYL SULFIDE (SULFUR MUSTARD, HD) SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID NAD+ LEVELS RP MEIER, HL (reprint author), USA,MED RES INST,CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 24 TC 37 Z9 37 U1 1 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD APR PY 1992 VL 113 IS 2 BP 234 EP 239 DI 10.1016/0041-008X(92)90119-D PG 6 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA HP304 UT WOS:A1992HP30400008 PM 1532867 ER PT J AU STILES, BG SEXTON, FW AF STILES, BG SEXTON, FW TI IMMUNOREACTIVITY, EPITOPE MAPPING AND PROTECTION STUDIES WITH ANTI-CONOTOXIN GI SERA AND VARIOUS CONOTOXINS SO TOXICON LA English DT Article ID TOXIGENIC ESCHERICHIA-COLI; CONUS-GEOGRAPHUS VENOM; AMINO-ACID-SEQUENCE; YERSINIA-ENTEROCOLITICA; MONOCLONAL-ANTIBODIES; NEUROTOXINS; PEPTIDES; BINDING; TOXINS AB Goat or rabbit anti-conotoxin GI sera recognized native or dithiothreitol-reduced alpha-conotoxins GI, MI and SI in an enzyme-linked immunosorbent assay (ELISA). Native mu-conotoxin GIIIA or omega-conotoxin GVIA did not react with either anti-conotoxin GI serum in the assay. The goat anti-conotoxin GI serum neutralized 2.5 LD50S Of alpha-conotoxins GI or MI in mouse lethal assays, while the rabbit antiserum had little protective capabilities. Epitope mapping of synthesized conotoxin peptide fragments revealed that both anti-conotoxin GI sera recognized linear sequences from five different alpha-conotoxins: GI, GIA, GII, MI and SI. The CCNPAC sequence was optimally recognized by both antisera. RP STILES, BG (reprint author), USA,MED RES INST INFECT DIS,DEPT TOXINOL,DIV PATHOPHYSIOL,FREDERICK,MD 21702, USA. NR 27 TC 5 Z9 5 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD APR PY 1992 VL 30 IS 4 BP 367 EP 377 DI 10.1016/0041-0101(92)90533-B PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA HW292 UT WOS:A1992HW29200001 PM 1378233 ER PT J AU MEGRET, F HUGNOT, JP FALCONAR, A GENTRY, MK MORENS, DM MURRAY, JM SCHLESINGER, JJ WRIGHT, PJ YOUNG, P VANREGENMORTEL, MHV DEUBEL, V AF MEGRET, F HUGNOT, JP FALCONAR, A GENTRY, MK MORENS, DM MURRAY, JM SCHLESINGER, JJ WRIGHT, PJ YOUNG, P VANREGENMORTEL, MHV DEUBEL, V TI USE OF RECOMBINANT FUSION PROTEINS AND MONOCLONAL-ANTIBODIES TO DEFINE LINEAR AND DISCONTINUOUS ANTIGENIC SITES ON THE DENGUE VIRUS ENVELOPE GLYCOPROTEIN SO VIROLOGY LA English DT Article ID BORNE ENCEPHALITIS-VIRUS; AMINO-ACID SEQUENCE; STRUCTURAL PROTEINS; ESCHERICHIA-COLI; TYPE-2 VIRUS; WEST NILE; FLAVIVIRUS; EPITOPES; IDENTIFICATION; DETERMINANTS C1 UNIV HAWAII,DIV TROP MED & MED MICROBIOL,HONOLULU,HI 96816. MONASH UNIV,DEPT MICROBIOL,CLAYTON,VIC 3168,AUSTRALIA. WALTER REED ARMY MED CTR,DEPT BIOCHEM,WASHINGTON,DC 20307. ROYAL CHILDRENS HOSP,SIR ALBERT SAKZEWSKI VIRUS RES LAB,BRISBANE,QLD 4029,AUSTRALIA. UNIV LONDON LONDON SCH HYG & TROP MED,LONDON WC1E 7HT,ENGLAND. INST BIOL MOLEC & CELLULAIRE,DEPT IMMUNOCHEM,F-67084 STRASBOURG,FRANCE. ROCHESTER GEN HOSP,DEPT MED,ROCHESTER,NY 14621. RP MEGRET, F (reprint author), INST PASTEUR,DEPT VIROL,F-75724 PARIS 15,FRANCE. RI Young, Paul/A-6176-2010 OI Young, Paul/0000-0002-2040-5190 NR 48 TC 107 Z9 113 U1 1 U2 4 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD APR PY 1992 VL 187 IS 2 BP 480 EP 491 DI 10.1016/0042-6822(92)90450-4 PG 12 WC Virology SC Virology GA HH591 UT WOS:A1992HH59100011 PM 1372140 ER PT J AU JOYE, GF PAUL, RN AF JOYE, GF PAUL, RN TI HISTOLOGY OF INFECTION OF HYDRILLA-VERTICILLATA BY MACROPHOMINA-PHASEOLINA SO WEED SCIENCE LA English DT Article DE BIOCONTROL; AQUATIC PLANTS; HISTOPATHOLOGY AB Infection of Hydrilla verticillata by Macrophomina phaseolina was investigated using scanning and transmission electron microscopy. Sprigs of plants in petri plates were inoculated with suspensions of fungal hyphae. Samples of inoculated and noninoculated plants were taken over time. Fungal cells attached to lower epidermal cell walls but not the upper epidermal cell walls of leaves. In less than 40 h, penetration through the cell wall was completed and colonization of host cells was observed. Penetration of upper epidermis was limited to the cell wall adjacent to a lower epidermal cell. No penetration was observed through the outer cell wall of upper epidermis. Inhibition of penetration through the outer cell wall of the upper epidermis may be attributable to an osmiophilic layer below the cell wall. Disruption of the host cell walls and subsequent host cell death was preceded by massive colonization of the host by this pathogen. C1 USA,WATERWAYS EXP STN,VICKSBURG,MS. USDA ARS,BIOL S WEED SCI LAB,STONEVILLE,MS 38776. NR 23 TC 7 Z9 7 U1 0 U2 1 PU WEED SCI SOC AMER PI CHAMPAIGN PA 309 W CLARK ST, CHAMPAIGN, IL 61820 SN 0043-1745 J9 WEED SCI JI Weed Sci. PD APR-JUN PY 1992 VL 40 IS 2 BP 288 EP 295 PG 8 WC Agronomy; Plant Sciences SC Agriculture; Plant Sciences GA JC083 UT WOS:A1992JC08300021 ER PT J AU CZERSKA, E CASAMENTO, J NING, J SWICORD, M ALBARAZI, H DAVIS, C ELSON, E AF CZERSKA, E CASAMENTO, J NING, J SWICORD, M ALBARAZI, H DAVIS, C ELSON, E TI COMPARISON OF THE EFFECT OF ELF ON C-MYC ONCOGENE EXPRESSION IN NORMAL AND TRANSFORMED HUMAN-CELLS SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID ELECTROMAGNETIC-FIELDS C1 UNIV MARYLAND,DEPT ELECT ENGN,COLL PK,MD 20742. WALTER REED ARMY MED CTR,DEPT MICROWAVE RES,WASHINGTON,DC 20307. RP CZERSKA, E (reprint author), US FDA,CTR DEVICES & RADIOL HLTH,ROCKVILLE,MD 20857, USA. NR 5 TC 11 Z9 11 U1 0 U2 1 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD MAR 31 PY 1992 VL 649 BP 340 EP 342 DI 10.1111/j.1749-6632.1992.tb49624.x PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JM217 UT WOS:A1992JM21700027 PM 1580505 ER PT J AU NING, J CASAMENTO, J CZERSKA, E SWICORD, M ALBARAZI, H DAVIS, C ELSON, E AF NING, J CASAMENTO, J CZERSKA, E SWICORD, M ALBARAZI, H DAVIS, C ELSON, E TI COMPARISON OF THE EFFECT OF ELF ON TOTAL RNA-CONTENT IN NORMAL AND TRANSFORMED HUMAN-CELLS SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID TRANSCRIPTION C1 UNIV MARYLAND,DEPT ELECT ENGN,COLL PK,MD 20742. WALTER REED ARMY MED CTR,DEPT MICROWAVE RES,WASHINGTON,DC 20307. RP NING, J (reprint author), US FDA,CTR DEVICES & RADIOL HLTH,ROCKVILLE,MD 20857, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD MAR 31 PY 1992 VL 649 BP 353 EP 355 DI 10.1111/j.1749-6632.1992.tb49628.x PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JM217 UT WOS:A1992JM21700031 PM 1374596 ER PT J AU CALDERON, L LU, Y SHEN, H PAMULAPATI, J DUTTA, M CHANG, WH YANG, LW WRIGHT, PD AF CALDERON, L LU, Y SHEN, H PAMULAPATI, J DUTTA, M CHANG, WH YANG, LW WRIGHT, PD TI PHOTOLUMINESCENCE CHARACTERIZATION OF NONRADIATIVE RECOMBINATION IN CARBON-DOPED GAAS SO APPLIED PHYSICS LETTERS LA English DT Article ID CURRENT GAIN; P-GAAS; VELOCITY AB Room-temperature photoluminescence is used to investigate the basic recombination mechanisms in carbon-doped GaAs samples, with hole concentrations ranging from 3.0 x 10(16) to 1.2 x 10(20) cm-3. The solution of a one-dimensional, steady-state continuity equation for minority carriers indicates that in heavily carbon-doped GaAs, surface recombination is minimal, while bulk nonradiative recombination is dominant. The bulk nonradiative recombination rate depends not only on p2, which represents Auger recombination, but also on p3. By using a single p+-GaAs:C (1 x 10(20) cm-3) base layer in an AlGaAs/GaAs heterojunction bipolar transistor, the surface recombination is minimized. C1 USA,ELECTR TECHNOL & DEVICES LAB,SLCET,ED,FT MONMOUTH,NJ 07703. FORD MICROELECTR INC,COLORADO SPRINGS,CO 80921. RP CALDERON, L (reprint author), RUTGERS STATE UNIV,DEPT ELECTR & COMP ENGN,PISCATAWAY,NJ 08855, USA. NR 15 TC 14 Z9 14 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 30 PY 1992 VL 60 IS 13 BP 1597 EP 1599 DI 10.1063/1.107483 PG 3 WC Physics, Applied SC Physics GA HL734 UT WOS:A1992HL73400024 ER PT J AU YAN, L KRIEGER, JB IAFRATE, GJ AF YAN, L KRIEGER, JB IAFRATE, GJ TI NEGATIVE-IONS AS DESCRIBED BY KOHN-SHAM EXCHANGE-ONLY THEORY SO CHEMICAL PHYSICS LETTERS LA English DT Article ID DENSITY-FUNCTIONAL THEORY; EFFECTIVE-POTENTIAL METHOD; ELECTRON-AFFINITIES; ENERGIES; ATOMS AB Exchange-only calculations using the optimized effective potential method and the method developed recently by Krieger, Li and Iafrate are performed for negative ions of alkalis, halogens and those with incomplete 2p and 3p shells. Comparisons are made with the results of Hartree-Fock as well as with those obtained by using the method proposed by Harbola and Sahni. C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP CUNY BROOKLYN COLL, DEPT PHYS, BROOKLYN, NY 11210 USA. NR 26 TC 40 Z9 40 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 EI 1873-4448 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD MAR 27 PY 1992 VL 191 IS 1-2 BP 38 EP 46 DI 10.1016/0009-2614(92)85365-H PG 9 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA HM768 UT WOS:A1992HM76800007 ER PT J AU FALVEY, DE CRAMER, CJ AF FALVEY, DE CRAMER, CJ TI ARYLNITRENIUM AND ALKYLNITRENIUM IONS - SINGLET-TRIPLET GAPS VIA ABINITIO AND SEMIEMPIRICAL METHODS SO TETRAHEDRON LETTERS LA English DT Article ID NITRENIUM IONS; STATES AB The accuracy of semi-empirically predicted singlet-triplet energy gaps for substituted nitrenium ions is examined by comparison to correlated (CISD), ab initio calculations. Unrealistically low singlet energies are delivered by both the AM1 and MNDO method with the differences being rather random for AM1, but quite consistent for MNDO. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP FALVEY, DE (reprint author), UNIV MARYLAND,DEPT CHEM & BIOCHEM,COLLEGE PK,MD 20742, USA. RI Falvey, Daniel/B-7817-2009; Cramer, Christopher/B-6179-2011 OI Cramer, Christopher/0000-0001-5048-1859 NR 19 TC 57 Z9 57 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0040-4039 J9 TETRAHEDRON LETT JI Tetrahedron Lett. PD MAR 24 PY 1992 VL 33 IS 13 BP 1705 EP 1708 PG 4 WC Chemistry, Organic SC Chemistry GA HL425 UT WOS:A1992HL42500009 ER PT J AU HUTCHINSON, JA ALLIK, TH AF HUTCHINSON, JA ALLIK, TH TI DIODE ARRAY-PUMPED ER, YB - PHOSPHATE-GLASS LASER SO APPLIED PHYSICS LETTERS LA English DT Article ID ERBIUM AB A diode-array side-pumped Er, Yb: phosphate glass laser has been constructed. Pumped with two 970 nm, InGaAs strained-layer diode arrays, a long pulse slope efficiency of 14% was obtained, with thresholds of 60 mJ input, a maximum output pulse energy of 20 mJ, and with output wavelengths at 1545 +/- 12 nm. When Q-switched, the laser generated 0.3 mJ, 50 ns FWHM pulses at an output wavelength of 1533 +/- 1 nm. Visible upconversion emission in the laser rod was observed. C1 SCI APPLICAT INT CORP,MCLEAN,VA 22102. RP HUTCHINSON, JA (reprint author), USA,CECOM NIGHT VIS & ELECTROOPT DIRECTORATE,FT BELVOIR,VA 22060, USA. NR 9 TC 100 Z9 100 U1 1 U2 5 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 23 PY 1992 VL 60 IS 12 BP 1424 EP 1426 DI 10.1063/1.107310 PG 3 WC Physics, Applied SC Physics GA HK373 UT WOS:A1992HK37300005 ER PT J AU GANT, TA SHEN, H FLEMISH, JR FOTIADIS, L DUTTA, M AF GANT, TA SHEN, H FLEMISH, JR FOTIADIS, L DUTTA, M TI RAMAN-STUDY OF LOW GROWTH TEMPERATURE GAAS SO APPLIED PHYSICS LETTERS LA English DT Article ID MOLECULAR-BEAM EPITAXY AB A Raman study has been made of GaAs grown by MBE at low temperature, which is known to produce nonstoichiometric (As-rich) material. The epilayer has a slightly larger lattice constant than the GaAs substrate, as measured by x-ray diffraction. Raman measurements show that the LO phonon of LT-GaAs is shifted down in frequency from that of bulk GaAs. The shift is related to the presence of As(Ga) antisite defects, which cause a reduction in the electric field associated with the LO phonon. After the sample was annealed, the epilayer had the same lattice constant as the substrate, and the LO phonon moved closer to that of bulk GaAs. C1 GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. RP GANT, TA (reprint author), USA,SLCET ED,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 10 TC 26 Z9 27 U1 0 U2 6 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 23 PY 1992 VL 60 IS 12 BP 1453 EP 1455 DI 10.1063/1.107268 PG 3 WC Physics, Applied SC Physics GA HK373 UT WOS:A1992HK37300015 ER PT J AU METCALF, VL FULLER, CR SILCOX, RJ BROWN, DE AF METCALF, VL FULLER, CR SILCOX, RJ BROWN, DE TI ACTIVE CONTROL OF SOUND-TRANSMISSION RADIATION FROM ELASTIC PLATES BY VIBRATION INPUTS .2. EXPERIMENTS SO JOURNAL OF SOUND AND VIBRATION LA English DT Article C1 VIRGINIA POLYTECH INST & STATE UNIV,BLACKSBURG,VA 24061. NASA,LANGLEY RES CTR,HAMPTON,VA 23665. LOCKHEED ENGN & SCI CO,HAMPTON,VA 23666. RP METCALF, VL (reprint author), USA,LANGLEY RES CTR,AVSCOM,AVIAT RES & TECHNOL ACT,HAMPTON,VA 23665, USA. NR 6 TC 22 Z9 23 U1 0 U2 3 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0022-460X J9 J SOUND VIB JI J. Sound Vibr. PD MAR 22 PY 1992 VL 153 IS 3 BP 387 EP 402 DI 10.1016/0022-460X(92)90372-5 PG 16 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA HL113 UT WOS:A1992HL11300001 ER PT J AU MEDARY, RT AF MEDARY, RT TI INEXPENSIVE, RAPID FIELD SCREENING-TEST FOR 2,4,6-TRINITROTOLUENE IN SOIL SO ANALYTICA CHIMICA ACTA LA English DT Article DE SOIL; TNT; TRINITROTOLUENE AB Simplified laboratory and field screening tests for 2,4,6-trinitrotoluene (TNT) in soil are described along with data supporting their validity. For field screening, an amount of soil (6 g) is vigorously shaken with 35 ml of methanol. Addition of 2 drops of 10% aqueous sodium hydroxide to 3 ml of the decantate results in a pink to purple color, the absorbance at 516 nm is directly proportional to the concentration of the TNT in the soil. The detection limit is estimated to be in the range of 4-8 ppm. The results of these screening tests correlate well with LC results. RP MEDARY, RT (reprint author), USA CORPS ENGINEERS,DIV ENGN,ENVIRONM SUPPORT SECT,601 E 12TH ST,KANSAS CITY,MO 64106, USA. NR 12 TC 28 Z9 28 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD MAR 20 PY 1992 VL 258 IS 2 BP 341 EP 346 DI 10.1016/0003-2670(92)85111-I PG 6 WC Chemistry, Analytical SC Chemistry GA HK842 UT WOS:A1992HK84200019 ER PT J AU KHALED, EEM HILL, SC BARBER, PW CHOWDHURY, DQ AF KHALED, EEM HILL, SC BARBER, PW CHOWDHURY, DQ TI NEAR-RESONANCE EXCITATION OF DIELECTRIC SPHERES WITH PLANE-WAVES AND OFF-AXIS GAUSSIAN BEAMS SO APPLIED OPTICS LA English DT Note ID STIMULATED RAMAN-SCATTERING; DROPLETS AB Modes having high-Q morphology-dependent resonances (MDR's) can dominate the internal energy distribution in spheres even when excited by many linewidths from the resonant location. C1 USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP KHALED, EEM (reprint author), CLARKSON UNIV,DEPT ELECT & COMP ENGN,POTSDAM,NY 13699, USA. NR 8 TC 45 Z9 45 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAR 20 PY 1992 VL 31 IS 9 BP 1166 EP 1169 PG 4 WC Optics SC Optics GA HJ278 UT WOS:A1992HJ27800002 PM 20720734 ER PT J AU CHATFIELD, DC FRIEDMAN, RS SCHWENKE, DW TRUHLAR, DG AF CHATFIELD, DC FRIEDMAN, RS SCHWENKE, DW TRUHLAR, DG TI CONTROL OF CHEMICAL-REACTIVITY BY QUANTIZED TRANSITION-STATES SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID MECHANICAL REACTION PROBABILITIES; POTENTIAL-ENERGY SURFACE; PHASE-SPACE BOTTLENECKS; PATH HAMILTONIAN MODEL; QUANTAL RATE CONSTANTS; THERMAL RATE CONSTANTS; PHOTODETACHMENT SPECTRUM; TUNNELING CALCULATIONS; COLLINEAR REACTIONS; + H AB We review the basic principles of quantized transition state control of microcanonical ensemble rate constants and state-selected rate constants. Selected examples are presented for the H + H-2 and O + H-2 reactions. The following aspects are emphasized: (i) We can calculate accurate quantal microcanonical rate constants up to high energies. (ii) These rate constants show resolvable structure which may be attributed to quantized transition states. (iii) The energy dependence of the microcanonical rate constants can be explained quantitatively using a transition state plus tunneling model based on these quantized transition states. (iv) Fitting the model of quantized transition states plus tunneling to the accurate quantum dynamics yields energies, transmission coefficients, and effective barrier widths for individual energy levels of the transition state. (v) The energy level spectrum can be assigned using the conventional model for a complex with a missing degree of freedom. The spectrum is in good agreement with that predicted by the adiabatic theory of reactions or variational transition state theory. The deviations may provide a quantitative test of approximations typically involved in such calculations, e.g., neglect of anharmonic mode couplings. (vi) The individual transmission coefficients show that the quantitative errors in transition state theory (about 10% at the highest energy considered) result from large breakdowns for a few bend-excited levels rather than from small (say 10%) breakdowns for all transition state levels. (vii) The transition state effective barrier widths can be understood both in terms of the barrier widths of vibrationally adiabatic potential curves and in terms of resonance theory. (vii) Transition state resonance theory also allows predictions of transition state lifetimes on the basis of fits to the energy derivative of the microcanonical rate constant. (ix) We can calculate half-collision transition probabilities for specific reactant states to proceed to particular states of the activated complex and for particular states of the activated complex to proceed to specific states of the products; this allows for a very detailed picture of how state-to-state reactions occur. (x) The analysis of state-selected reactivity in terms of passage through particular transition states explains trends in the dependence of rate constants on initial vibrational and rotational quantum numbers. C1 UNIV MINNESOTA, DEPT CHEM, INST SUPERCOMP, MINNEAPOLIS, MN 55455 USA. UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. NASA, AMES RES CTR, MOFFETT FIELD, CA 94035 USA. RI schwenke, david/I-3564-2013; Truhlar, Donald/G-7076-2015 OI Truhlar, Donald/0000-0002-7742-7294 NR 120 TC 90 Z9 91 U1 2 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD MAR 19 PY 1992 VL 96 IS 6 BP 2414 EP 2421 DI 10.1021/j100185a007 PG 8 WC Chemistry, Physical SC Chemistry GA HK717 UT WOS:A1992HK71700007 ER PT J AU MAGILL, AJ GASSER, RA OSTER, CN GROGL, M SUN, W AF MAGILL, AJ GASSER, RA OSTER, CN GROGL, M SUN, W TI VISCEROTROPIC LEISHMANIASIS IN PERSONS RETURNING FROM OPERATION-DESERT-STORM 1990-1991 (REPRINTED FROM MORBIDITY AND MORTALITY WEEKLY, VOL 41, PG 131-134, 1992) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint ID VISCERAL LEISHMANIASIS; CUTANEOUS LEISHMANIASIS; REGION C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. WILLIAM BEAUMONT ARMY MED CTR,INFECT DIS SERV,EL PASO,TX 79920. CTR DIS CONTROL,NATL CTR INFECT DIS,DIV PARASIT DIS,ATLANTA,GA 30333. RP MAGILL, AJ (reprint author), WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307, USA. NR 12 TC 3 Z9 3 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 18 PY 1992 VL 267 IS 11 BP 1444 EP 1446 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA HH488 UT WOS:A1992HH48800006 ER PT J AU ROSSOW, MP MOSHER, RL AF ROSSOW, MP MOSHER, RL TI DESIGN OF CELLULAR COFFERDAMS BY THE CCELL COMPUTER-PROGRAM SO COMPUTERS & STRUCTURES LA English DT Article AB CCELL is a computer program for the analysis and design of cellular cofferdams and mooring cells. The theoretical basis of the program is explained in sufficient detail to enable a designer to determine if the program is appropriate for his or her needs. Two design examples are presented. C1 USA,ENGINEER WATERWAYS EXPT STN,DIV COMP AIDED ENGN,VICKSBURG,MS 39180. RP ROSSOW, MP (reprint author), SO ILLINOIS UNIV,DEPT CIVIL ENGN,EDWARDSVILLE,IL 62026, USA. NR 23 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-7949 J9 COMPUT STRUCT JI Comput. Struct. PD MAR 17 PY 1992 VL 42 IS 6 BP 979 EP 988 DI 10.1016/0045-7949(92)90108-C PG 10 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA HN403 UT WOS:A1992HN40300011 ER PT J AU CAMBIER, PA KIRBY, WC WORTHAM, DC MOORE, JW AF CAMBIER, PA KIRBY, WC WORTHAM, DC MOORE, JW TI PERCUTANEOUS CLOSURE OF THE SMALL (LESS-THAN-2.5 MM) PATENT DUCTUS-ARTERIOSUS USING COIL EMBOLIZATION SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Note ID CATHETER OCCLUSION; OCCLUDER RP CAMBIER, PA (reprint author), WALTER REED ARMY MED CTR,CARDIOL SERV,WASHINGTON,DC 20307, USA. NR 12 TC 202 Z9 217 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD MAR 15 PY 1992 VL 69 IS 8 BP 815 EP 816 DI 10.1016/0002-9149(92)90514-Y PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA HJ098 UT WOS:A1992HJ09800023 PM 1546662 ER PT J AU MORRIS, JT MCALLISTER, CK AF MORRIS, JT MCALLISTER, CK TI CEFOTETAN-INDUCED SINGULTUS SO ANNALS OF INTERNAL MEDICINE LA English DT Letter ID HICCUPS RP MORRIS, JT (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 4 Z9 4 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD MAR 15 PY 1992 VL 116 IS 6 BP 522 EP 523 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA HJ598 UT WOS:A1992HJ59800025 PM 1739250 ER PT J AU HEIER, J ENZENAUER, RW LAPIANA, FG AF HEIER, J ENZENAUER, RW LAPIANA, FG TI OCULAR INJURIES AT A COMBAT SUPPORT HOSPITAL IN SUPPORT OF OPERATIONS DESERT SHIELD AND STORM SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. FITZSIMONS ARMY MED CTR,AURORA,CO 80045. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1992 VL 33 IS 4 BP 782 EP 782 PG 1 WC Ophthalmology SC Ophthalmology GA HK135 UT WOS:A1992HK13500445 ER PT J AU DELCERRO, M LAZAR, E CVETKOVICH, T GENDELMAN, H BLUMBERG, B DZENKO, K DELCERRO, C EPSTEIN, L AF DELCERRO, M LAZAR, E CVETKOVICH, T GENDELMAN, H BLUMBERG, B DZENKO, K DELCERRO, C EPSTEIN, L TI A SMALL ANIMAL-MODEL OF HIV-1 INFECTION OF NEURAL TISSUE - INTRAOCULAR XENOGRAFTS OF HUMAN FETAL RETINA AND BRAIN SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV ROCHESTER,SCH MED,ROCHESTER,NY 14627. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1992 VL 33 IS 4 BP 851 EP 851 PG 1 WC Ophthalmology SC Ophthalmology GA HK135 UT WOS:A1992HK13500800 ER PT J AU CAVALLARO, BE WARD, TP PEELE, KA HOLLIFIELD, RD WERTZ, FD AF CAVALLARO, BE WARD, TP PEELE, KA HOLLIFIELD, RD WERTZ, FD TI CLOSURE OF SCLERAL LACERATIONS WITH CYANOACRYLATE ADHESIVE SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1992 VL 33 IS 4 BP 1311 EP 1311 PG 1 WC Ophthalmology SC Ophthalmology GA HK135 UT WOS:A1992HK13503086 ER PT J AU BILLOCK, VA HARDING, TH AF BILLOCK, VA HARDING, TH TI STATISTICAL INDEPENDENCE OF SPATIOTEMPORAL CONTRAST THRESHOLDS AS A FUNCTION OF FREQUENCY SEPARATION - DIFFERENCES IN SPATIAL AND TEMPORAL PROCESSING SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,AEROMED RES LAB,FT RUCKER,AL 36362. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1992 VL 33 IS 4 BP 1344 EP 1344 PG 1 WC Ophthalmology SC Ophthalmology GA HK135 UT WOS:A1992HK13503242 ER PT J AU CHATFIELD, DC TRUHLAR, DG SCHWENKE, DW AF CHATFIELD, DC TRUHLAR, DG SCHWENKE, DW TI STATE-SELECTED CHEMICAL-REACTION DYNAMICS AT THE S-MATRIX LEVEL - FINAL-STATE SPECIFICITIES OF NEAR-THRESHOLD PROCESSES AT LOW AND HIGH-ENERGIES SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID VARIATIONAL-METHODS; CROSS-SECTIONS; COLLISIONS; VIBRATION; SURFACES; ROTATION AB State-to-state reaction probabilities are found to be highly final-state specific at state-selected threshold energies for the reactions O + H-2 --> OH + H and H + H-2 --> H-2 + H. The study includes initial rotational states with quantum numbers 0-15, and the specificity is especially dramatic for the more highly rotationally excited reactants. The analysis is based on accurate quantum mechanical reactive scattering calculations. Final-state specificity is shown in general to increase with the rotational quantum number of the reactant diatom, and the trends are confirmed for both zero and nonzero values of the total angular momentum. C1 UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. NASA, AMES RES CTR, MOFFETT FIELD, CA 94035 USA. RP CHATFIELD, DC (reprint author), UNIV MINNESOTA, INST SUPERCOMP, DEPT CHEM, MINNEAPOLIS, MN 55455 USA. RI schwenke, david/I-3564-2013; Truhlar, Donald/G-7076-2015 OI Truhlar, Donald/0000-0002-7742-7294 NR 31 TC 9 Z9 9 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD MAR 15 PY 1992 VL 96 IS 6 BP 4313 EP 4323 DI 10.1063/1.462824 PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA HK019 UT WOS:A1992HK01900029 ER PT J AU WHITE, CJ RAMEE, SR BANKS, AK MESA, JE CHOKSHI, S ISNER, JM AF WHITE, CJ RAMEE, SR BANKS, AK MESA, JE CHOKSHI, S ISNER, JM TI A NEW BALLOON-EXPANDABLE TANTALUM COIL STENT - ANGIOGRAPHIC PATENCY AND HISTOLOGIC-FINDINGS IN AN ATHEROGENIC SWINE MODEL SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article ID LUMINAL CORONARY ANGIOPLASTY; ATHEROSCLEROTIC RABBIT AORTAS; BLOOD-INSTITUTE; PTCA REGISTRY; ENDOPROSTHESES; RESTENOSIS; PLACEMENT; ARTERIES; PROGRESS; GRAFT AB The angiographic patency and histologic characteristics of a new balloon-expandable tantalum stent were studied after implantation intervals ranging from 1 to 32 weeks in atherogenic miniature swine peripheral and coronary arteries. Stents were placed in 34 arteries (10 coronary and 24 iliac arteries) in a total of 13 swine. Two swine died within 24 h of stent implantation. Follow-up angiography was performed before death was induced in 11 swine (8 coronary and 19 iliac arteries) and revealed 100% patency without evidence of lumen stenosis, thrombosis or migration of the stents. The neointimal thickening was maximal at 4 weeks after stent implantation and was at its minimum at 32 weeks after implantation with reendothelialization of the stents generally complete at that time. An advantage of this balloon-expandable device is its inherent longitudinal flexibility. The coil configuration allowed the nondeployed stent to negotiate acute bends in coronary arteries to reach the site of implantation and also allowed the deployed stent to conform to the natural contour of tortuous coronary arteries. The tantalum device was remarkable for its radiographic visibility, which greatly aided its placement under fluoroscopic guidance. This study demonstrates this stent's ease of implantation, excellent patency rate and absence of restenosis due to neointimal proliferation for up to 8 months in this atherogenic swine model. C1 ALTON OCHSNER MED FDN & OCHSNER CLIN,DEPT INTERNAL MED,CARDIOL SECT,NEW ORLEANS,LA 70121. WALTER REED ARMY MED CTR,DEPT INTERNAL MED,SERV CARDIOL,WASHINGTON,DC 20307. ST ELIZABETH HOSP,DEPT INTERNAL MED,BOSTON,MA. RI White, Christopher/J-6686-2012 OI White, Christopher/0000-0001-8618-7539 NR 27 TC 40 Z9 40 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD MAR 15 PY 1992 VL 19 IS 4 BP 870 EP 876 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA HJ636 UT WOS:A1992HJ63600026 PM 1545083 ER PT J AU YU, FTS YANG, XY GREGORY, DA AF YU, FTS YANG, XY GREGORY, DA TI POLYCHROMATIC NEURAL NETWORKS SO OPTICS COMMUNICATIONS LA English DT Article ID MODEL; IMPLEMENTATION; CRYSTAL; NETS AB A polychromatic optical neural network using cascaded liquid crystal televisions (LCTV) is presented and simulated which uses a polychromatic interconnection weight matrix (IWM) for color pattern recognition. Extension of the polychromatic neural net for multichannel operation is also proposed. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP YU, FTS (reprint author), PENN STATE UNIV,DEPT ELECT & COMP ENGN,UNIV PK,PA 16802, USA. NR 14 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD MAR 15 PY 1992 VL 88 IS 2-3 BP 81 EP 86 DI 10.1016/0030-4018(92)90489-E PG 6 WC Optics SC Optics GA HK403 UT WOS:A1992HK40300001 ER PT J AU COWDREY, A AF COWDREY, A TI THE GREATEST GOOD TO THE GREATEST NUMBER - PENICILLIN RATIONING ON THE AMERICAN HOME FRONT, 1940-1945 - ADAMS,DP SO SCIENCE LA English DT Book Review RP COWDREY, A (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20314, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD MAR 13 PY 1992 VL 255 IS 5050 BP 1450 EP 1450 DI 10.1126/science.255.5050.1450 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA HH744 UT WOS:A1992HH74400063 PM 17801237 ER PT J AU CHIANG, PK BURBELO, PD BRUGH, SA GORDON, RK FUKUDA, K YAMADA, Y AF CHIANG, PK BURBELO, PD BRUGH, SA GORDON, RK FUKUDA, K YAMADA, Y TI ACTIVATION OF COLLAGEN-IV GENE-EXPRESSION IN F9 TERATOCARCINOMA CELLS BY 3-DEAZAADENOSINE ANALOGS - INDIRECT INHIBITORS OF METHYLATION SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID S-ADENOSYLHOMOCYSTEINE HYDROLASE; DNA METHYLATION; DIFFERENTIATION; ALPHA-1(IV); PROMOTER; POTENT AB 3-Deazaadenosine analogs can function as inhibitors and also as alternative substrates of S-adenosylhomocysteine (AdoHcy) hydrolase. In cells treated with the analogs, AdoHcy invariably accumulates, leading to inhibition of cellular methylation. F9 teratocarcinoma cells, stably transfected with two collagen (IV) promoter-enhancer-CAT constructs and treated with 10-mu-M 3-deazaadenosine, 3-deaza-(+/-)-aristeromycin or 3-deazaneplanocin, showed a strong induction of CAT activities without affecting differentiation. In comparison, the same 3-deaza analogs did not affect the CAT activity in F9 cells transfected with the beta-actin promoter-CAT construct. Furthermore, Northern blot analysis of endogenous mRNA from wild-type F9 cells treated with the 3-deaza nucleosides all showed an induction of the collagen alpha-1(IV) chain mRNA. Thus, the 3-deaza analogs most likely affect DNA methylation because their results are consistent with the previous observation that the integrated collagen alpha-1(IV) promoter-enhancer constructs were activated with 5 azacytidine. C1 NIDA,BETHESDA,MD 20892. RP CHIANG, PK (reprint author), WALTER REED ARMY MED CTR,APPL BIOCHEM BRANCH,WASHINGTON,DC 20307, USA. RI Burbelo, Peter/B-1027-2009 NR 29 TC 30 Z9 30 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAR 5 PY 1992 VL 267 IS 7 BP 4988 EP 4991 PG 4 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA HF642 UT WOS:A1992HF64200103 PM 1537874 ER PT J AU TANGREA, JA EDWARDS, BK TAYLOR, PR HARTMAN, AM PECK, GL SALASCHE, SJ MENON, PA BENSON, PM MELLETTE, JR GUILL, MA ROBINSON, JK GUIN, JD STOLL, HL GRABSKI, WJ WINTON, GB AF TANGREA, JA EDWARDS, BK TAYLOR, PR HARTMAN, AM PECK, GL SALASCHE, SJ MENON, PA BENSON, PM MELLETTE, JR GUILL, MA ROBINSON, JK GUIN, JD STOLL, HL GRABSKI, WJ WINTON, GB TI LONG-TERM THERAPY WITH LOW-DOSE ISOTRETINOIN FOR PREVENTION OF BASAL-CELL CARCINOMA - A MULTICENTER CLINICAL-TRIAL SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article ID SKELETAL HYPEROSTOSIS DISH; 13-CIS-RETINOIC ACID; SPINAL HYPEROSTOSIS; ORAL ISOTRETINOIN; ICHTHYOSIS; TOXICITY; ACNE AB Background: High-dose isotretinoin has been reported to have a prophylactic effect on nonmelanoma skin cancer, although it is associated with significant toxicity. Purpose: To test the effectiveness of the long-term administration of low-dose isotretinoin in reducing the occurrence of basal cell carcinoma at a new site in patients with previously treated basal cell carcinomas and to measure the toxicity associated with this regimen, we conducted a clinical trial at eight cancer centers. Methods: Nine hundred and eighty-one patients with two or more previously confirmed basal cell carcinomas were randomly assigned to receive either 10 mg of isotretinoin or a placebo daily. Patients were followed for 36 months and monitored at 6-month intervals for skin cancer and toxic effects. Results: After 36 months of treatment, no statistically significant difference in either the cumulative percent of patients with an occurrence of basal cell carcinoma at a new site or the annual rate of basal cell carcinoma formation existed between patients receiving isotretinoin and those receiving the placebo. Elevated serum triglycerides, hyperostotic axial skeletal changes, and mucocutaneous reactions were more frequent in the group receiving isotretinoin than in the control group, and these differences were all statistically significant (P < .001). Conclusion: This low-dose regimen of isotretinoin not only is ineffective in reducing the occurrence of basal cell carcinoma at new sites in patients with two or more previously treated basal cell carcinomas but also is associated with significant adverse systemic effects. Implication: The toxicity associated with the long-term administration of isotretinoin, even at the low dose used in this trial, must be weighed in planning future prevention trials. C1 EISENHOWER ARMY MED CTR,AUGUSTA,GA. NORTHWESTERN UNIV,CHICAGO,IL 60611. UNIV ARKANSAS,LITTLE ROCK,AR 72204. NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,BUFFALO,NY 14263. USN HOSP,PORTSMOUTH,VA. FITZSIMONS ARMY MED CTR,AURORA,CO 80045. NCI,DIV CANC PREVENT & CONTROL,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. BROOKE ARMY MED CTR,SAN ANTONIO,TX. NR 35 TC 118 Z9 120 U1 0 U2 4 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD MAR 4 PY 1992 VL 84 IS 5 BP 328 EP 332 DI 10.1093/jnci/84.5.328 PG 5 WC Oncology SC Oncology GA HU102 UT WOS:A1992HU10200014 PM 1738183 ER PT J AU MATHER, B AF MATHER, B TI MODELING THE STRUCTURAL EFFECTS OF ALKALI-AGGREGATE REACTIONS ON REINFORCED-CONCRETE SO ACI MATERIALS JOURNAL LA English DT Discussion C1 USA,STRUCT LAB,WATERWAYS EXPT STN,WASHINGTON,DC 20310. RP MATHER, B (reprint author), AMER CONCRETE INST,DETROIT,MI 48219, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 INTERNATIONAL WAY, COUNTRY CLUB DRIVE, PO BOX 9094, FARMINGTON HILLS, MI 48333-9094 SN 0889-325X J9 ACI MATER J JI ACI Mater. J. PD MAR-APR PY 1992 VL 89 IS 2 BP 211 EP 212 PG 2 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA HM990 UT WOS:A1992HM99000014 ER PT J AU WALKER, EH AF WALKER, EH TI CANCER AS A MECHANISM OF HYPERMUTATION SO ACTA BIOTHEORETICA LA English DT Article ID CELLS; MICE; DNA; EVOLUTION AB The highly structured mechanisms of cancers, their tendency to occur as a response to environmental stress, and the existence of oncogenes, suggest that neoplasticity may represent more than a biological disfunction. It is proposed that cancer exists as a phylogenetic mechanism serving to promote "hyperevolution", albeit at the expense of the ontogeny, that is similar to a process recently discovered in bacterial mutations. Cell-surface-associated nucleic acid in tumorigenic cells and sperm cell vectorization of foreign DNA indicate the existence of essential mechanisms necessary to the occurrence of cancer mediated hyperevolution. An analysis of the proposed mechanism indicates that for mutagenesis of chemical cytology, stress induced neoplasticity confers an evolutionary advantage of more than two orders of magnitude. C1 WALKER CANC RES INST INC,ABERDEEN,MD 21001. RP WALKER, EH (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 28 TC 1 Z9 1 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0001-5342 J9 ACTA BIOTHEOR JI Acta Biotheor. PD MAR PY 1992 VL 40 IS 1 BP 31 EP 40 PG 10 WC Mathematical & Computational Biology SC Mathematical & Computational Biology GA HX593 UT WOS:A1992HX59300004 PM 1626443 ER PT J AU DEB, KK HILL, MD ROTH, RS KELLY, JF AF DEB, KK HILL, MD ROTH, RS KELLY, JF TI DIELECTRIC AND PYROELECTRIC PROPERTIES OF DOPED LEAD ZINC NIOBATE (PZN) CERAMIC MATERIALS SO AMERICAN CERAMIC SOCIETY BULLETIN LA English DT Article ID SYSTEM; PHASE AB Relaxor ferroelectric materials based on lead zinc niobate (PZN) are candidate materials for IR sensors in night vision equipment. Pyroelectric measurements, as well as measurements of the dielectric constant versus temperature and frequency, were performed. Crystallographic and grain size data are also presented. The peak temperature for the dielectric constant differs from that of the pyroelectric coefficient contributing to a high figure of merit for a pyroelectric IR detector material. C1 NATL INST STAND & TECHNOL,DIV CERAM,ELECTR MAT GRP,GAITHERSBURG,MD 20899. USA,ELECTROOPT DIRECTORATE,FT BELVOIR,VA 22060. RP DEB, KK (reprint author), USA,CECOM,CTR NIGHT VIS,FT BELVOIR,VA 22060, USA. NR 14 TC 4 Z9 4 U1 0 U2 1 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7812 J9 AM CERAM SOC BULL JI Am. Ceram. Soc. Bull. PD MAR PY 1992 VL 71 IS 3 BP 349 EP 354 PG 6 WC Materials Science, Ceramics SC Materials Science GA HH557 UT WOS:A1992HH55700014 ER PT J AU ARTHUR, JD BODHIDATTA, L ECHEVERRIA, P PHUPHAISAN, S PAUL, S AF ARTHUR, JD BODHIDATTA, L ECHEVERRIA, P PHUPHAISAN, S PAUL, S TI DIARRHEAL DISEASE IN CAMBODIAN CHILDREN AT A CAMP IN THAILAND SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE CAMPYLOBACTER; CRYPTOSPORIDIUM; DIARRHEA; ESCHERICHIA-COLI; REFUGEES; ROTAVIRUSES; SHIGELLA ID ENTEROAGGREGATIVE ESCHERICHIA-COLI; CAMPYLOBACTER-JEJUNI; YOUNG-CHILDREN; PERSISTENT DIARRHEA; DNA HYBRIDIZATION; INTERVENTIONS; CRYPTOSPORIDIUM; INFANTS; CELLS AB The etiology of acute diarrhea (less-than-or-equal-to 3 days duration) and persistent diarrhea (greater-than-or-equal-to 14 days duration) was determined in Cambodian children under age 5 years in a refugee camp on the Thai-Cambodian border between May and October 1989; potential risk factors associated with persistent diarrhea were examined in an age-matched case-control study. Specimens collected from children and environmental sources were examined by standard microbiologic methods; Escherichia coli isolates were examined for hybridization with specific DNA probes and in tissue culture adherence assays. The same bacterial, viral, or parasitic agents were identified in 79 children with persistent diarrhea and in 408 children with acute diarrhea. Only one of nine children with persistent diarrhea excreted the same organism, Cryptosporidium, for that extended period. The most important risk factors identified for developing persistent diarrhea were living with other young children (odds ratio (OR) = 2.0, 95% confidence interval (CI) 1.2-3.4) and being undernourished (OR = 2.6, 95% CI 1.2-5.7). Persistent diarrhea in children in this camp was associated with several different agents rather than persistent infections with a single organism. C1 ARMED FORCES RES INST MED SCI,DEPT BACTERIOL,315 6 RAJVITHI RD,BANGKOK 10400,THAILAND. CATHOLIC RELIEF SERV,SURIN,THAILAND. UN BORDER RELIEF OPERAT,ARANYAPRATHET,THAILAND. NR 35 TC 13 Z9 13 U1 1 U2 1 PU JOHNS HOPKINS UNIV SCHOOL HYGIENE PUB HEALTH PI BALTIMORE PA 111 MARKET PLACE, STE 840, BALTIMORE, MD 21202-6709 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD MAR 1 PY 1992 VL 135 IS 5 BP 541 EP 551 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA HR190 UT WOS:A1992HR19000010 PM 1570820 ER PT J AU TIWARY, CM HOLGUIN, AH AF TIWARY, CM HOLGUIN, AH TI PREVALENCE OF OBESITY AMONG CHILDREN OF MILITARY DEPENDENTS AT 2 MAJOR MEDICAL-CENTERS SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID OVERWEIGHT; CHILDHOOD; ADOLESCENTS; ENVIRONMENT AB Background. Prevalence of childhood obesity is unknown among military dependents. We ascertained the prevalence among all children aged 1 year or older attending the pediatric and adolescent clinics at the Walter Reed Army Medical Center (WRAMC) during 1978 and the Brooke Army Medical Center (BAMC) during 1986 and 1990. Methods: Obesity was defined according to the child's relative weight computed from growth charts of the National Center for Health Statistics. Results. The study sample included 1715 children (1078 at BAMC, 637 at WRAMC). Among them, 14.8% were overweight, 10.8% were obese, and 7.7% (3.0% males, 4.7% females) were grossly obese. The prevalence of grossly obese children was 5.5% at WRAMC and 9.0% at BAMC; 11.5% among children of retirees and 7.3% among children of active duty personnel (P < .008); 5.5% among children of officers and 12.2% among children of sergeants (P < .0005). The prevalence of very obese children was 10.1% for those older than 12 years of age and 3.3% for those aged 6 years or younger (P < .0001). Conclusions. Retiree status of the sponsor was more important than sponsor's rank or child's age in determining the prevalence of childhood obesity. Prevalence of obesity approximately doubled over the 8 to 12 years of the study. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. UNIV TEXAS,HLTH SCI CTR,SCH PUBL HLTH,SAN ANTONIO,TX 78284. RP TIWARY, CM (reprint author), BROOKE ARMY MED CTR,DEPT PEDIAT,FT SAM HOUSTON,TX 78234, USA. NR 27 TC 11 Z9 11 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD MAR PY 1992 VL 82 IS 3 BP 354 EP 357 DI 10.2105/AJPH.82.3.354 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA HL802 UT WOS:A1992HL80200005 PM 1536349 ER PT J AU BURKE, DS AF BURKE, DS TI INTRODUCTION TO THE 1991 ASTMH PRESIDENTIAL-ADDRESS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Editorial Material RP BURKE, DS (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. OI /0000-0002-5704-8094 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 1992 VL 46 IS 3 BP 239 EP 240 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA HM470 UT WOS:A1992HM47000001 PM 1558262 ER PT J AU HERWALDT, BL BERMAN, JD AF HERWALDT, BL BERMAN, JD TI RECOMMENDATIONS FOR TREATING LEISHMANIASIS WITH SODIUM STIBOGLUCONATE (PENTOSTAM) AND REVIEW OF PERTINENT CLINICAL-STUDIES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VISCERAL LEISHMANIASIS; CUTANEOUS LEISHMANIASIS; KALA-AZAR; MUCOSAL LEISHMANIASIS; EFFICACY; KENYA; REGIMENS; INDIA AB Pentavalent antimonial compounds have been the mainstay of the treatment of visceral, cutaneous, and mucosal leishmaniasis for approximately half a century. Pentostam (sodium stibogluconate) is the pentavalent antimonial compound available in the United States (through the Centers for Disease Control). As dosage regimens for treating leishmaniasis have evolved, the daily dose of antimony and the duration of therapy have been progressively increased to combat unresponsiveness to therapy. In the 1980s, the use of 20 mg/kg/day (instead of 10 mg/kg/day) of antimony was recommended, but only to a maximum daily dose of 850 mg. The authors have concluded on the basis of recent efficacy and toxicity data that this 850-mg restriction should be removed; the evidence to date, which is summarized here, suggests that a regimen of 20 mg/kg/day of pentavalent antimony, without an upper limit on the daily dose, is more efficacious and is not substantially more toxic than regimens with lower daily doses. We recommend treating all forms of leishmaniasis with a full 20 mg/kg/day of pentavalent antimony. We treat cutaneous leishmaniasis for 20 days and visceral and mucosal leishmaniasis for 28 days. Our judgment of cure is based on clinical criteria. C1 WALTER REED ARMY MED CTR,DIRECTORS OFF,WASHINGTON,DC 20307. RP HERWALDT, BL (reprint author), US DEPT HHS,CTR DIS CONTROL,NATL CTR INFECT DIS,PUBL HLTH SERV,DIV PARASIT DIS,ATLANTA,GA 30333, USA. NR 25 TC 295 Z9 305 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 1992 VL 46 IS 3 BP 296 EP 306 PG 11 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA HM470 UT WOS:A1992HM47000010 PM 1313656 ER PT J AU FRANKE, ED LUCAS, CM CHAUCA, G WIRTZ, RA HINOSTROZA, S AF FRANKE, ED LUCAS, CM CHAUCA, G WIRTZ, RA HINOSTROZA, S TI ANTIBODY-RESPONSE TO THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-VIVAX IN NATURALLY INFECTED HUMANS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SPOROZOITES; EPITOPE; ANTIGEN; VACCINE; REPEAT; SERA AB The circumsporozoite (CS) protein of Plasmodium vivax consists of a central repeat region flanked by highly conserved non-repeat regions. Serum samples from 33 individuals with naturally acquired infections of P. vivax were tested for antibodies to four antigens representing the vivax CS protein. Three recombinant proteins containing different overlapping sequences in the non-repeat regions and either the entire central repeat region (vivax-1 and vivax-2) or two of the repeat sequences (vivax-3) were used as antigens in an enzyme-linked immunosorbent assay (ELISA). Antibodies to two other proteins, one (NS1(81)V20) containing the entire predominant repeat region (GDRAA/DGQPA) and the other (Pvk247) containing the variant repeat sequence (ANGAGNQPG) that was recently reported from Thailand were also measured by ELISA. Immunoglobulin G antibodies to the antigen representing the predominant repeat were present in 15% of the patients on the first day of treatment (day 0) and in 24% of the patients two weeks later (post-treatment). Six and 12% of the patients had IgG antibodies to the antigen containing the variant repeat on day 0 and post-treatment, respectively. A larger proportion of the sera had antibodies to the three antigens containing the non-repeat sequences; on the first day of treatment and two weeks later, 79 and 97% of the patients, respectively, had antibodies to vivax-1, vivax-2, and vivax-3. In this sample of Peruvians naturally infected with P. vivax, the most prevalent antibody responses were targeted to epitopes in the non-repeat region of the CS protein rather than to epitopes in the repeat region. The exact location of the non-repeat epitopes and their relevance to immunity to sporozoites deserve further investigation. C1 CTR MED NAVAL CMST,LIMA,PERU. WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307. RP FRANKE, ED (reprint author), USN,MED RES INST DETACHMENT,LIMA,PERU. RI Villasante, Eileen/G-3602-2011 NR 17 TC 12 Z9 12 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 1992 VL 46 IS 3 BP 320 EP 326 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA HM470 UT WOS:A1992HM47000013 PM 1373042 ER PT J AU HOSKING, MP MONGAN, PD PETERSON, RE AF HOSKING, MP MONGAN, PD PETERSON, RE TI REMOVAL OF A LARGE INTRATHORACIC TUMOR IN A CHILD - NEUROGENIC MOTOR-EVOKED POTENTIAL MONITORING OF SPINAL-CORD INTEGRITY AND ANESTHETIC MANAGEMENT SO ANESTHESIA AND ANALGESIA LA English DT Article ID STIMULATION; PARAPLEGIA; INTUBATION; PATHWAYS; SURGERY; HUMANS C1 BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234. NR 25 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD MAR PY 1992 VL 74 IS 3 BP 460 EP 463 PG 4 WC Anesthesiology SC Anesthesiology GA HF475 UT WOS:A1992HF47500023 PM 1539828 ER PT J AU THOMAS, JG AF THOMAS, JG TI AN ALTERNATIVE DIAPHRAGM FOR PATIL-SYRACUSE MASKS SO ANESTHESIA AND ANALGESIA LA English DT Letter RP THOMAS, JG (reprint author), BROOKE ARMY MED CTR,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD MAR PY 1992 VL 74 IS 3 BP 473 EP 473 DI 10.1213/00000539-199203000-00036 PG 1 WC Anesthesiology SC Anesthesiology GA HF475 UT WOS:A1992HF47500036 PM 1539836 ER PT J AU KENWORTHY, KL HOFFMAN, J ROGERS, JN AF KENWORTHY, KL HOFFMAN, J ROGERS, JN TI A NEW DRESSING TECHNIQUE FOR TEMPORARY PERCUTANEOUS CATHETERS USED FOR PAIN MANAGEMENT SO ANESTHESIOLOGY LA English DT Letter ID EPIDURAL CATHETERS C1 BROOKE ARMY MED CTR,DEPT SURG,OPERAT SERV,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,PAIN MANAGEMENT CLIN,ANESTHESIOL & PAIN MANAGEMENT CLIN STAFF,SAN ANTONIO,TX 78234. RP KENWORTHY, KL (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA SERV,FT SAM HOUSTON,TX 78234, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD MAR PY 1992 VL 76 IS 3 BP 482 EP 483 DI 10.1097/00000542-199203000-00036 PG 2 WC Anesthesiology SC Anesthesiology GA HG476 UT WOS:A1992HG47600036 PM 1539869 ER PT J AU BOYLAN, KB FERRIERO, DM GRECO, CM SHELDON, RA DEW, M AF BOYLAN, KB FERRIERO, DM GRECO, CM SHELDON, RA DEW, M TI CONGENITAL HYPOMYELINATION NEUROPATHY WITH ARTHROGRYPOSIS MULTIPLEX CONGENITA SO ANNALS OF NEUROLOGY LA English DT Note ID NEWBORN; NERVE AB A term male infant is described with an isolated disorder of peripheral myelination. At necropsy, the great majority of medium-to-large axons were unmyelinated. Electron microscopy showed normal axons and redundant lamination of basement membrane, suggestive of early onion bulb pathology. Immunohistochemistry of peripheral nerve showed deficiency of the myelin proteins P2 and Po, myelin basic protein, and myelin-associated glycoprotein. Arrest of peripheral myelination at the promyelin stage appears to be the origin of myelin deficiency. C1 JOHNS HOPKINS UNIV,DEPT NEUROL,BALTIMORE,MD 21218. UNIV CALIF SAN FRANCISCO,DEPT NEUROL,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,DEPT PEDIAT,SAN FRANCISCO,CA 94143. CHILDRENS HOSP,DEPT NEUROPATHOL,SAN FRANCISCO,CA 94119. DWIGHT D EISENHOWER ARMY MED CTR,DEPT PSYCHIAT,FT GORDON,GA 30905. DWIGHT D EISENHOWER ARMY MED CTR,DEPT NEUROL,FT GORDON,GA 30905. NR 13 TC 37 Z9 37 U1 0 U2 0 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0364-5134 J9 ANN NEUROL JI Ann. Neurol. PD MAR PY 1992 VL 31 IS 3 BP 337 EP 340 DI 10.1002/ana.410310318 PG 4 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA HQ121 UT WOS:A1992HQ12100017 PM 1637141 ER PT J AU GILLESPIE, JB LINDBERG, JD AF GILLESPIE, JB LINDBERG, JD TI MEASURING ABSOLUTE DIFFUSE REFLECTANCE IN THE ULTRAVIOLET SO APPLIED OPTICS LA English DT Article AB An improvement is provided on a previously published method for determining absolute diffuse reflectance by using any spectroreflectometer that is capable of relative reflectance measurements. The improvement extends the applicability of the method to the UV and IR spectral ranges and improves overall accuracy. A comparison example of the earlier method and the improved version applied to the same set of data are provided. Values for the Kubelka-Munk absorption coefficients and scattering coefficients are given for the 0.25-0.60-mu-m spectral region. C1 SCI & TECHNOL CORP,LAS CRUCES,NM 88001. RP GILLESPIE, JB (reprint author), USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 10 TC 1 Z9 1 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAR 1 PY 1992 VL 31 IS 7 BP 955 EP 959 PG 5 WC Optics SC Optics GA HE657 UT WOS:A1992HE65700015 PM 20720706 ER PT J AU HORNG, S HIROSE, Y KAHN, A WRENN, C PFEFFER, R AF HORNG, S HIROSE, Y KAHN, A WRENN, C PFEFFER, R TI CA0.5SR0.5F2/GAAS(100) FOR EPITAXIAL REGROWTH AND ELECTRON-BEAM PATTERNING SO APPLIED SURFACE SCIENCE LA English DT Article; Proceedings Paper CT 3RD INTERNATIONAL CONF ON THE FORMATION OF SEMICONDUCTOR INTERFACES ( ICFSI-3 ) CY MAY 06-10, 1991 CL ITALIAN NATL RES COUNCIL, ROME, ITALY SP CNR, IST NAZL FIS NUCL, SINCROTRONE TRIESTE, IBM ITALIA, PERKIN ELMER, CASSA RISPARMIO ROMA HO ITALIAN NATL RES COUNCIL ID FLUORIDE AB Layers of GaAs and Ca0.5Sr0.5F2 are grown by molecular beam epitaxy. The morphology, orientation, composition and crystallinity of the layers are analyzed as a function of growth temperature and surface treatment. The fluoride layers show a high degree of crystallinity and a smooth surface morphology. The crystallinity and morphology of the GaAs overlayer are improved by electron irradiation of the fluoride surface prior to GaAs growth followed by a two-step growth procedure for the GaAs overlayer. A technique of electron-beam patterning of the fluoride layer is developed and the formation of 3-5-mu-m features is demonstrated. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP HORNG, S (reprint author), PRINCETON UNIV,DEPT ELECT ENGN,PRINCETON,NJ 08544, USA. RI Schaff, William/B-5839-2009 NR 7 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-4332 J9 APPL SURF SCI JI Appl. Surf. Sci. PD MAR PY 1992 VL 56-8 BP 855 EP 860 DI 10.1016/0169-4332(92)90350-7 PN B PG 6 WC Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA HM078 UT WOS:A1992HM07800047 ER PT J AU WALKER, WE AF WALKER, WE TI COMPARING ARMY RESERVE FORCES - A TALE OF MULTIPLE IRONIES, CONFLICTING REALITIES, AND MORE CERTAIN PROSPECTS SO ARMED FORCES & SOCIETY LA English DT Article AB In spite of the "total force" policy, Army reserve forces are fraught with ironies, contradictions, and paradoxes and continue to be at odds with the regular Army. And yet, reserve forces perform a variety of essential military roles both nationally and locally, the most important of which is serving as the popular face of the Army. It seems clear that the reserves will play a more significant role in the post-cold war era. Over the next decade military reformers will force the Army to rely more heavily on reservists in a newly redesigned total force. Thus the question is not whether changes in the Army's reliance on reserve forces will be imposed by outsiders, but whether these changes will occur with or without the Army's active support. In the 1990s the Congress is also likely to increase the relative status of Army reserve components. Indeed, reserve forces may become the great pork barrel in American politics during the 1990s. RP WALKER, WE (reprint author), US MIL ACAD,DEPT SOCIAL SCI,W POINT,NY 10996, USA. NR 41 TC 9 Z9 9 U1 0 U2 1 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SPR PY 1992 VL 18 IS 3 BP 303 EP 322 DI 10.1177/0095327X9201800301 PG 20 WC Political Science; Sociology SC Government & Law; Sociology GA HR218 UT WOS:A1992HR21800001 ER PT J AU FILBERT, MG APLAND, JP PETRALI, JP ADLER, M AF FILBERT, MG APLAND, JP PETRALI, JP ADLER, M TI PARAOXON BLOCK OF CHLORIDE CONDUCTANCE IN CELL R2 OF APLYSIA-CALIFORNICA SO BRAIN RESEARCH BULLETIN LA English DT Article DE APLYSIA-CALIFORNICA; CELL R2; PARAOXON; ACETYLCHOLINE; GAMMA-AMINOBUTYRIC ACID; ACETYLCHOLINESTERASE; CHLORIDE CHANNELS; VOLTAGE CLAMP ID MUSCLE; ACETYLCHOLINE; FROG AB In the presence of paraoxon, the amplitudes of chloride currents activated by acetylcholine (ACh) or gamma-aminobutyric acid (GABA) were reduced in cell R2 of Aplysia californica. IC50 values were 12 and 9.7-mu-M for ACh and GABA responses, respectively. Paraoxon did not affect resting membrane potential, input resistance, or chloride reversal potential. Both the slopes and maxima of ACh and GABA concentration-response curves were reduced by paraoxon, suggesting that paraoxon antagonism of these responses is not competitive. The antagonism of ACh and GABA responses by paraoxon was not related to inhibition of acetylcholinesterase. C1 USA,MED RES INST CHEM DEF,COMPARAT PATHOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. RP FILBERT, MG (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 24 TC 6 Z9 6 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0361-9230 J9 BRAIN RES BULL JI Brain Res. Bull. PD MAR PY 1992 VL 28 IS 3 BP 473 EP 477 DI 10.1016/0361-9230(92)90049-4 PG 5 WC Neurosciences SC Neurosciences & Neurology GA HM255 UT WOS:A1992HM25500015 PM 1375524 ER PT J AU FRUCHT, H GAZDAR, AF PARK, JA OIE, H JENSEN, RT AF FRUCHT, H GAZDAR, AF PARK, JA OIE, H JENSEN, RT TI CHARACTERIZATION OF FUNCTIONAL RECEPTORS FOR GASTROINTESTINAL HORMONES ON HUMAN COLON CANCER-CELLS SO CANCER RESEARCH LA English DT Article ID VASOACTIVE INTESTINAL PEPTIDE; HIGH-AFFINITY RECEPTORS; HUMAN GASTRIC-CARCINOMA; SWISS 3T3 CELLS; LUNG-CANCER; VIP RECEPTORS; LINE HGT-1; MOLECULAR-IDENTIFICATION; MUSCARINIC RECEPTORS; REGULATORY PEPTIDES AB Studies demonstrate that some colon cancers possess receptors for various gastrointestinal hormones or neurotransmitters, the occupation of which can affect growth. These results are limited because frequently only a small number of tumors are studied, only 1 or 2 receptors are sought, and the effect on cell function is not investigated. In the present study, 10 recently characterized human colon cancer cell lines were studied to determine whether they possess receptors for any of 12 different gastrointestinal hormones or neurotransmitters and to determine whether these receptors mediate changes in cellular function. Each of the cell lines exhibited receptors for at least one radioligand. Receptors for vasoactive intestinal peptide (VIP) and muscarinic cholinergic agents occurred on 60%, bombesin and gastrin on 30%, beta-adrenergic agents and gastrin-releasing peptide (GRP) on 20%, and somatostatin, opiates, neuromedin B, and substance P on 10%. Analysis of [H-3]N-methylscopolamine binding revealed a K(d) of 0.2 nM for N-methylscopolamine with a binding capacity of 2500 sites/cell. With the agonist carbamylcholine, the receptor exhibited 2 classes of binding sites: one of high affinity (K(d) 55-mu-M) representing 75% of the binding sites and one of low affinity (K(d) 0.3 mM) representing 25% of the binding sites. Analysis of I-125-[Tyr4]bombesin binding revealed a receptor of high affinity (K(d) 2.1-mu-M) with a binding capacity of 3300 sites/cell. Inhibition of binding by agonists revealed relative potencies of I-125-[Tyr4]bombesin > GRP >> neuromedin B, and two recently described antagonists were similar in potency to GRP. Analysis of I-125-VIP binding revealed a receptor having 2 classes of binding sites: one of high affinity (K(d) 3.6 nM) and one of low affinity (K(d) 1.7-mu-M) which represented the majority of the 5.5 x 10(6) binding sites/cell. The relative potencies of agonists were VIP > helodermin > peptide histidine methionine > secretin. Evaluation of biological activity mediated by the muscarinic cholinergic and bombesin receptors revealed an increase of intracellular calcium and of inositol triphosphate by specific receptor agonists. The presence or absence of receptors detected by binding correlated closely with the ability of selective receptor agonists to alter cell function. These results demonstrate the presence of several different receptors for gastrointestinal hormones or neurotransmitters, some described for the first time, on human colon cancer cell lines, including bombesin-related peptides, VIP, somatostatin, substance P, beta-adrenergic agents, calcitonin gene-related peptide, gastrin, muscarinic cholinergic agents, and opiates. These receptors are functional because occupation by selective agonists altered intracellular mediators. These results suggest that it will be important to extend these studies to evaluate growth effects. C1 NIDDKD,BLDG 10,ROOM 9C-103,BETHESDA,MD 20892. NCI,USA,MED ONCOL BRANCH,BETHESDA,MD 20892. RI Park, Jae-Gahb/J-5494-2012 NR 60 TC 114 Z9 114 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD MAR 1 PY 1992 VL 52 IS 5 BP 1114 EP 1122 PG 9 WC Oncology SC Oncology GA HF637 UT WOS:A1992HF63700010 PM 1310640 ER PT J AU BERG, BW DILLARD, TA RAJAGOPAL, KR MEHM, WJ AF BERG, BW DILLARD, TA RAJAGOPAL, KR MEHM, WJ TI OXYGEN SUPPLEMENTATION DURING AIR-TRAVEL IN PATIENTS WITH CHRONIC OBSTRUCTIVE LUNG-DISEASE SO CHEST LA English DT Article AB The objective of this study was to quantitate the effects of O2 supplementation by nasal cannula (NC) and Venturi mask (VM) on PaO2 in patients with chronic obstructive pulmonary disease (COPD) during acute hypobaric exposure, simulating a commercial jet aircraft cabin. We conducted a crossover intervention trial in which subjects served as their own controls in an ambulatory outpatient pulmonary disease service of a tertiary care military medical center and a hypobaric research facility. The subjects were a volunteer sample of 18 men with stable severe COPD, not requiring long-term O2 therapy, and uncomplicated by hypercapnea or cardiac disease. Mean age was 68 years, and mean FEV1 was 0.97 L (31.3 percent predicted). We exposed patients to conditions equivalent to 8,000 feet in a hypobaric chamber. Radial artery catheters provided blood samples at ground level and 8,000 feet. O2 was sequentially administered at 8,000 feet by NC at 4 L/min and 24 percent or 28 percent VM. We describe changes in blood gas data from baseline values and between interventions. O2 at 4 L/min NC flow at 8,000 feet caused PaO2 to increase from 47.4 +/- 6.3 mm Hg to 82.3 +/- 14 mm Hg (n = 18), an increase of 34.9 +/- 14.8 mm Hg. Supplementation of O2 by 24 percent VM caused PaO2 at 8,000 feet to increase by 12.7 +/- 3.8 mm Hg. Twenty-eight percent VM caused PaO2 at 8,000 feet to increase by 19.7 +/- 8.2 mm Hg. Changes in PaO2 with 4 L/min NC were greater than those with either VM. The increase with 28 percent VM was greater than that caused by 24 percent VM (p < 0.05). Compared with ground level, 4 L/min NC increased mean PaO2 by 9.9 +/- 12.6 mm Hg; 24 percent and 28 percent VM did not cause mean PaO2 to increase above ground level values. We describe a range of capability of familiar O2 therapy devices to increase PaO2 to levels that will maintain tissue oxygenation of patients during acute altitude exposure. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. ARMED FORCES INST PATHOL,DIV ALTITUDE & HYPERBAR PHYSIOL,WASHINGTON,DC 20306. RP BERG, BW (reprint author), WALTER REED ARMY MED CTR,DEPT MED,BLDG 2,RM 6316,WASHINGTON,DC 20307, USA. NR 15 TC 38 Z9 39 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD MAR PY 1992 VL 101 IS 3 BP 638 EP 641 DI 10.1378/chest.101.3.638 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA HG784 UT WOS:A1992HG78400014 PM 1541125 ER PT J AU SHIPPEE, RL JOHNSON, AA CIOFFI, WG LASKO, J LEVOYER, TE JORDAN, BS AF SHIPPEE, RL JOHNSON, AA CIOFFI, WG LASKO, J LEVOYER, TE JORDAN, BS TI SIMULTANEOUS DETERMINATION OF LACTULOSE AND MANNITOL IN URINE OF BURN PATIENTS BY GAS-LIQUID-CHROMATOGRAPHY SO CLINICAL CHEMISTRY LA English DT Article ID INTESTINAL PERMEABILITY; CELIAC-DISEASE AB Ratios of lactulose/mannitol excretion in urine have been used to assess the extent of intestinal permeability in various disease and trauma conditions. Reported studies have used this technique to correlate altered gastrointestinal mucosal permeability to translocation of bacteria and endotoxin, leading to occult sepsis in burn patients. Enzymatic methods of analysis for urine concentrations of mannitol and lactulose were used in these studies. We have found that urine from patients with severe burns frequently contains compounds that interfere with the enzymatic methods. We describe using gas-liquid chromatography to determine mannitol and lactulose simultaneously in the urine of burn patients. To avoid the multiple peaks for the anomeric forms of the reducing sugars during precolumn trimethylsilyl derivatization, we converted the sugars to oximes before the silylation step. The method gave good recoveries of mannitol and lactulose added to burn patients' urine samples. Unlike the enzymatic methods, gas-liquid chromatography eliminates the effect of interfering compounds and allows for the simultaneous determination of both sugars in urine samples. RP SHIPPEE, RL (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 8 TC 32 Z9 33 U1 0 U2 1 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD MAR PY 1992 VL 38 IS 3 BP 343 EP 345 PG 3 WC Medical Laboratory Technology SC Medical Laboratory Technology GA HJ870 UT WOS:A1992HJ87000005 PM 1547549 ER PT J AU BRYAN, JP SJOGREN, MH PERINE, PL LEGTERS, LJ AF BRYAN, JP SJOGREN, MH PERINE, PL LEGTERS, LJ TI LOW-DOSE INTRADERMAL AND INTRAMUSCULAR VACCINATION AGAINST HEPATITIS-B SO CLINICAL INFECTIOUS DISEASES LA English DT Review ID MENTALLY-RETARDED PATIENTS; PLASMA-DERIVED VACCINE; NEW-ZEALAND CHILDREN; IMMUNE-RESPONSE; ANTIBODY-RESPONSE; VIRUS-INFECTION; RECOMBINANT-DNA; IMMUNOGENICITY; IMMUNIZATION; BOOSTER AB Hepatitis B and its sequelae are global problems preventable by immunization. Expense limits the use of hepatitis B vaccines, but low-dose intradermal immunization has been evaluated as a cost-saving strategy in numerous studies. With few exceptions, low-dose intradermal plasma-derived vaccines have elicited protective levels of antibody in 82%-100% of young healthy adults - a proportion similar to that noted with full-dose regimens; peak levels of antibody to hepatitis B surface antigen (HBsAg) are lower with reduced doses, however. Although children respond well to low-dose intradermal immunization, this procedure is technically difficult in neonates and should not be used for those born to HBsAg-positive mothers. For persons at high risk, antibody to HBsAg must be assessed after immunization to determine the need for a booster dose. A fourth dose 1-2 years after the initial series substantially increases antibody concentrations. In low intradermal doses, recombinant vaccine elicits lower rates of seroconversion than plasma-derived vaccine. However, low intramuscular doses of recombinant vaccine give favorable results. In short, low-dose intradermal or intramuscular immunization offers protection against hepatitis B at significant savings and may be useful for mass immunization of populations at high risk. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP BRYAN, JP (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMET,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 87 TC 52 Z9 54 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR PY 1992 VL 14 IS 3 BP 697 EP 707 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HE701 UT WOS:A1992HE70100011 PM 1532914 ER PT J AU MORRIS, JT LONGFIELD, RN AF MORRIS, JT LONGFIELD, RN TI LOFGREN SYNDROME DIAGNOSED AS ACUTE RHEUMATIC-FEVER IN A MILITARY RECRUIT SO CLINICAL INFECTIOUS DISEASES LA English DT Letter RP MORRIS, JT (reprint author), BROOKE ARMY MED CTR,DEPT MED,INFECT DIS SERV,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR PY 1992 VL 14 IS 3 BP 781 EP 782 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HE701 UT WOS:A1992HE70100021 PM 1562667 ER PT J AU MORRIS, JT LONGFIELD, RN AF MORRIS, JT LONGFIELD, RN TI MENINGITIS AND BACTEREMIA DUE TO NONTYPABLE HAEMOPHILUS-INFLUENZAE IN ADULTS SO CLINICAL INFECTIOUS DISEASES LA English DT Letter ID NONTYPABLE HEMOPHILUS-INFLUENZAE; DISEASE; SPECTRUM RP MORRIS, JT (reprint author), BROOKE ARMY MED CTR,DEPT MED,INFECT DIS SERV,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 4 Z9 4 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR PY 1992 VL 14 IS 3 BP 782 EP 783 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HE701 UT WOS:A1992HE70100022 PM 1562668 ER PT J AU SHANLEY, DJ BUCKNER, AB AF SHANLEY, DJ BUCKNER, AB TI ESTHESIONEUROBLASTOMA DEMONSTRATED ON BONE-SCAN - CORRELATION WITH CT AND MRI SO CLINICAL NUCLEAR MEDICINE LA English DT Article RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,DIV NUCL MED,HONOLULU,HI, USA. NR 4 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD MAR PY 1992 VL 17 IS 3 BP 231 EP 232 DI 10.1097/00003072-199203000-00016 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA HJ469 UT WOS:A1992HJ46900016 PM 1611796 ER PT J AU COOK, BA BASS, JW NOMIZU, S ALEXANDER, ME AF COOK, BA BASS, JW NOMIZU, S ALEXANDER, ME TI SEDATION OF CHILDREN FOR TECHNICAL PROCEDURES - CURRENT STANDARD OF PRACTICE SO CLINICAL PEDIATRICS LA English DT Article ID COMPUTED-TOMOGRAPHY; INFANTS; SCAN; CT AB We sought to define the current standard of care for children undergoing sedation for painless diagnostic procedures by sending questionnaires to 284 pediatric residency program directors in North America. From the 89 responses, we determined that departments of pediatrics set sedation policies for children in most institutions, often with formal written guidelines for these procedures. Most require that children have some form of cardiorespiratory monitoring while under sedation and that they are attended by individuals trained in cardiorespiratory resuscitation until the child is fully recovered. The use of parents to transport and monitor the sedated child is uncommon, and total lack of monitoring is rare. Chloral hydrate in dosages of 25 mg/kg to 100 mg/kg is the most common drug used for sedation; DPT, a combination of parenteral Demerol (meperidine), Phenergan (promethazine), and Thorazine (chlorpromazine), at a maximum dose of 2 mg/1mg/1mg/kg is the second; and pentobarbital in a dosage of 5 mg/kg to 7 mg/kg is the third. These sedation regimens were associated with few serious side effects, except that two deaths were reported in infants with congenital heart disease who were sedated with DPT. We believe this survey may reflect the current standard of practice for sedation in North American infants and children undergoing diagnostic procedures. C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. NR 14 TC 53 Z9 53 U1 0 U2 0 PU WESTMINSTER PUBL INC PI GLEN HEAD PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD MAR PY 1992 VL 31 IS 3 BP 137 EP 142 DI 10.1177/000992289203100302 PG 6 WC Pediatrics SC Pediatrics GA HK419 UT WOS:A1992HK41900002 PM 1547584 ER PT J AU NIELSEN, R ENDRUSICK, TL AF NIELSEN, R ENDRUSICK, TL TI LOCALIZED TEMPERATURES AND WATER-VAPOR PRESSURES WITHIN CLOTHING DURING ALTERNATE EXERCISE REST IN THE COLD SO ERGONOMICS LA English DT Article DE SWEATING; CLOTHING; TEMPERATURE; HUMIDITY; COLD; EXERCISE ID VENTILATION; INSULATION; TRANSPORT; MOVEMENT; POSTURE; COTTON; WIND AB The purpose of this study was to determine the variation of localized skin temperatures, clothing surface temperatures and water vapour pressures within a clothing system when worn during alternating work/rest cycles in a cold environment. A two-layer prototype clothing system comprising underwear and a uniform was studied on eight subjects (T(a) = T(r)BAR = 5-degrees-C; T(dp) = -3.5-degrees-C; nu(a) = 0.32 m s-1; I(tot) = 0.24 m2 K W-1). The 2 h experiment comprised a twice-repeated bout of 40 min cycle exercise (W = 56 W m-2; M = 313 W m-2) followed by 20 min of rest (M = 62 W m-2). Esophageal, skin, clothing, and ambient temperatures, as well as dew-point temperatures near the skin, in the clothing and in the environment were monitored. In addition, evaporation of sweat and sweat accumulated in the clothing were determined. The temperatures and water vapour pressures in all clothing layers varied significantly with the human thermoregulatory responses (skin temperature, sweating) to alternating work/rest cycles. Different courses of localized corresponding temperatures and water vapour pressures indicated that various forms of heat transport and heat exchange in the skin-clothing-environment system are of significance in different body areas. C1 USA,ENVIRONM MED RES INST,DIV BIOPHYS & BIOMED MODELLING,NATICK,MA 01760. RP NIELSEN, R (reprint author), TECH UNIV DENMARK,HEATING & AIR CONDIT LAB,DK-2800 LYNGBY,DENMARK. NR 26 TC 13 Z9 13 U1 0 U2 2 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0014-0139 J9 ERGONOMICS JI Ergonomics PD MAR PY 1992 VL 35 IS 3 BP 313 EP 327 DI 10.1080/00140139208967816 PG 15 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA HL930 UT WOS:A1992HL93000007 PM 1572340 ER PT J AU TSANGARAKIS, N PELLETIER, GP PEPI, MS AF TSANGARAKIS, N PELLETIER, GP PEPI, MS TI RESPONSE OF AN ALUMINA FIBER-REINFORCED ALUMINUM COMPOSITE TO COMBINED TENSION TORSION SO EXPERIMENTAL MECHANICS LA English DT Article ID FATIGUE; DEFORMATION AB Aluminum coupons reinforced undirectionally with continuous alumina fibers were loaded in combined tension-torsion. Experimental results indicate that the super-imposition of a 0.0025 shear strain reduced the tensile strain to failure by 67 percent. Similarly, the superposition of a 0.0007 tensile strain reduced the shear strain to failure by 81 percent. It was inferred that applying the torque first and then the axial load or the axial load first and then the torque, had no significant affect on the failure envelope. The shear modulus was estimated to be 50.56.GPa. RP TSANGARAKIS, N (reprint author), USA,MAT TECHNOL LAB,SLCMT MRM,WATERTOWN,MA 02172, USA. NR 19 TC 1 Z9 1 U1 0 U2 1 PU SOC EXPERIMENTAL MECHANICS PI BETHEL PA 7 SCHOOL STREET, BETHEL, CT 06801 SN 0014-4851 J9 EXP MECH JI Exp. Mech. PD MAR PY 1992 VL 32 IS 1 BP 49 EP 53 DI 10.1007/BF02317985 PG 5 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA HR634 UT WOS:A1992HR63400009 ER PT J AU KEATE, RF SHAFFER, R AF KEATE, RF SHAFFER, R TI SEEDING OF HEPATOCELLULAR-CARCINOMA TO PERITONEOSCOPY INSERTION SITE SO GASTROINTESTINAL ENDOSCOPY LA English DT Letter ID FINE-NEEDLE ASPIRATION; BIOPSY; TUMORS RP KEATE, RF (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 11 TC 10 Z9 11 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAR-APR PY 1992 VL 38 IS 2 BP 203 EP 204 DI 10.1016/S0016-5107(92)70403-9 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA HM718 UT WOS:A1992HM71800031 PM 1314756 ER PT J AU HEWITT, AD AF HEWITT, AD TI POTENTIAL OF COMMON WELL CASING MATERIALS TO INFLUENCE AQUEOUS METAL CONCENTRATIONS SO GROUND WATER MONITORING AND REMEDIATION LA English DT Article AB Static leaching and sorption laboratory studies were performed to assess the potential of polyvinyl chloride (PVC), polytetrafluoroethylene (PTFE), and two types of stainless steel (SS 304 and SS 316) well casing materials to influence metal concentrations in ground water solutions with low dissolved oxygen. Overall, PTFE was inert, whereas one or both stainless steels significantly altered the solution concentrations of Cd, Cr, Cu, Pb, Fe, and Ni. PVC was generally more reactive than PTFE, but did not significantly alter the solution metal concentrations as often, or as greatly, as either of the stainless casings. RP HEWITT, AD (reprint author), COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 11 Z9 11 U1 0 U2 0 PU GROUND WATER PUBLISHING CO PI WESTERVILLE PA 601 DEMPSEY RD, WESTERVILLE, OH 43081 SN 1069-3629 J9 GROUND WATER MONIT R JI Ground Water Monit. Remediat. PD SPR PY 1992 VL 12 IS 2 BP 131 EP 136 DI 10.1111/j.1745-6592.1992.tb00043.x PG 6 WC Water Resources SC Water Resources GA HQ361 UT WOS:A1992HQ36100009 ER PT J AU ZHAO, JH BURKE, T LARSON, D WEINER, M CHIN, A BALLINGALL, JM YU, TH AF ZHAO, JH BURKE, T LARSON, D WEINER, M CHIN, A BALLINGALL, JM YU, TH TI DYNAMIC IV CHARACTERISTICS OF AN ALGAAS/GAAS-BASED OPTOTHYRISTOR FOR PULSED POWER-SWITCHING APPLICATIONS SO IEEE ELECTRON DEVICE LETTERS LA English DT Article AB A high-performance MBE-grown AlGaAs/GaAs-based heterostructure optothyristor has been fabricated and characterized for high-power pulsed switching applications. An LEC undoped semi-insulating GaAs of 650-mu-m in thickness was used as the voltage blocking layer and low-temperature GaAs grown at 200-degrees-C was used to passivate the surface and to reduce the surface leakage current. The dynamic current-voltage characteristics have been measured up to 115 A and 1974 V, which corresponds to a field intensity of more than 30 kV/cm. The dissipated energy per switching as a function of device voltage has also been determined to be in the range of 2 mJ or lower. C1 GE,ELECTR LAB,SYRACUSE,NY 13221. USA,LABCOM,ETD LAB,FT MONMOUTH,NJ 07703. RP ZHAO, JH (reprint author), RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855, USA. NR 14 TC 3 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD MAR PY 1992 VL 13 IS 3 BP 161 EP 163 DI 10.1109/55.144997 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA HE796 UT WOS:A1992HE79600009 ER PT J AU ALMAN, GM MOLTER, LA SHEN, H DUTTA, M AF ALMAN, GM MOLTER, LA SHEN, H DUTTA, M TI REFRACTIVE-INDEX APPROXIMATIONS FROM LINEAR PERTURBATION-THEORY FOR PLANAR MQW WAVE-GUIDES SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article ID MULTIPLE-QUANTUM-WELL; WAVE-GUIDES; OPTICAL BIREFRINGENCE; PROPAGATION AB The mode powers and propagation constants for planar multilayer waveguides formed with multiple quantum well (MQW) materials and with the MQW layers replaced by a single uniform layer are compared. By considering linear perturbations of the solutions of the wave equation, the optimal choice of average for the dielectric constant of the substituted single layer is determined. For the case of TE modes, minimal error in the propagation constant is predicted if a weighted average of the dielectric constants of the MQW materials is used. For the case of TM modes, using a weighted average of the reciprocal of the dielectric constants is predicted to yield the minimum error. Numerical results confirm these predictions. This substitution is applied to a waveguide with a single MQW-guiding region and the relative magnitude of the errors in the power distribution and propagation constant for symmetric and antisymmetric TE modes are explained. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP ALMAN, GM (reprint author), SWARTHMORE COLL,DEPT ENGN,SWARTHMORE,PA 19081, USA. NR 15 TC 40 Z9 40 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD MAR PY 1992 VL 28 IS 3 BP 650 EP 657 DI 10.1109/3.124989 PG 8 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA HG906 UT WOS:A1992HG90600012 ER PT J AU FORTIER, AH POLSINELLI, T GREEN, SJ NACY, CA AF FORTIER, AH POLSINELLI, T GREEN, SJ NACY, CA TI ACTIVATION OF MACROPHAGES FOR DESTRUCTION OF FRANCISELLA-TULARENSIS - IDENTIFICATION OF CYTOKINES, EFFECTOR-CELLS, AND EFFECTOR MOLECULES SO INFECTION AND IMMUNITY LA English DT Article ID TUMOR NECROSIS FACTOR; LISTERIA-MONOCYTOGENES; L-ARGININE; INTERFERON-GAMMA; LEISHMANIA-MAJOR; MONONUCLEAR PHAGOCYTES; MURINE MACROPHAGES; TOXOPLASMA-GONDII; CYTO-TOXICITY; RESISTANCE AB Francisella tularensis live vaccine strain (LVS) was grown in culture with nonadherent resident, starch-elicited, or Proteose Peptone-elicited peritoneal cells. Numbers of bacteria increased 4 logs over the input inoculum in 48 to 72 h. Growth rates were faster in inflammatory cells than in resident cells: generation times for the bacterium were 3 h in inflammatory cells and 6 h in resident macrophages. LVS-infected macrophage cultures treated with lymphokines did not support growth of the bacterium, although lymphokines alone had no inhibitory effects on replication of LVS in culture medium devoid of cells. Removal of gamma interferon (IFN-gamma) by immunoaffinity precipitation rendered lymphokines ineffective for induction of macrophage anti-LVS activity, and recombinant IFN-gamma stimulated both resident and inflammatory macrophage populations to inhibit LVS growth in vitro. Inflammatory macrophages were more sensitive to effects of IFN-gamma: half-maximal activity was achieved at 5 U/ml for inflammatory macrophages and 20 U/ml for resident macrophages. IFN-gamma-induced anti-LVS activity correlated with the production of nitrite (NO2-), an oxidative end product of L-arginine-derived nitric oxide (NO). Anti-LVS activity and nitrite production were both completely inhibited by the addition of either the L-arginine analog N(G)-monomethyl-L-arginine or anti-tumor necrosis factor antibodies to activated macrophage cultures. Thus, macrophages can be activated by IFN-gamma to suppress the growth of F. tularensis by generation of toxic levels of NO, and inflammatory macrophages are substantially more sensitive to activation activities of IFN-gamma for this effector reaction than are more differentiated resident cells. RP FORTIER, AH (reprint author), WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307, USA. NR 45 TC 153 Z9 153 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAR PY 1992 VL 60 IS 3 BP 817 EP 825 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA HH195 UT WOS:A1992HH19500016 PM 1541555 ER PT J AU LONGFIELD, RN WORTHAM, WG FLETCHER, LL NAUSCHEUTZ, WF AF LONGFIELD, RN WORTHAM, WG FLETCHER, LL NAUSCHEUTZ, WF TI CLUSTERED BACTEREMIAS IN A HEMODIALYSIS UNIT - CROSS-CONTAMINATION OF BLOOD TUBING FROM ULTRAFILTRATE WASTE SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Note ID PYROGENIC REACTIONS AB OBJECTIVE: To determine the cause of clustered bacteremias occurring among chronic hemodialysis patients. DESIGN: A retrospective investigation of clinical and laboratory records with direct observation of dialysis facilities and technique. Bacterial blood isolates were identified and compared with environmental isolates. SETTING: The 11-station chronic hemodialysis unit that serves approximately 50 patients in a 450-bed military hospital. PATIENTS: Hemodialysis unit patients with aerobic gram-negative bacillus or Enterococcus casseliflavus blood isolates between April 1988 and February 1990. RESULTS: The recovery and species identification of the unique isolate, E casseliflavus, from 2 index cases of bacteremia in February 1990 helped identify the cluster and demonstrated its protracted course. Dialysis blood tubing was contaminated with ultrafiltrate waste during dialyzer setup. INTERVENTION: Bacteremias were controlled by halting the practice of attaching the venous tubing directly to a waste container while priming the membrane, by emphasizing glove changes and handwashing after contact with ultrafiltrate waste and by daily decontamination of ultrafiltrate waste bags. CONCLUSIONS: We recommend that other hemodialysis units institute these interventions. C1 BROOKE ARMY MED CTR,CLIN MICROBIOL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,NEPHROL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,INFECT CONTROL SERV,FT SAM HOUSTON,TX 78234. RP LONGFIELD, RN (reprint author), BROOKE ARMY MED CTR,HSHE MDI,INFECT DIS SERV,FT SAM HOUSTON,TX 78234, USA. NR 13 TC 12 Z9 12 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD MAR PY 1992 VL 13 IS 3 BP 160 EP 164 PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA HJ130 UT WOS:A1992HJ13000012 PM 1564314 ER PT J AU BURTON, DM STITH, JA AF BURTON, DM STITH, JA TI EXTRALUMINAL ESOPHAGEAL COIN EROSION IN CHILDREN - CASE-REPORT AND REVIEW SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY LA English DT Article DE COIN; FOREIGN BODY; ESOPHAGEAL PERFORATION; EXTRALUMINAL MIGRATION ID FOREIGN-BODY; PERFORATION AB Coins are often reported as the most commonly ingested foreign body (FB) in children. They are felt to be benign FBs since they usually pass through the gastrointestinal tract without incident. However, when these objects become impacted within the esophageal lumen, they can perforate the esophagus and migrate extraluminally. Symptoms of the perforation itself are frequently absent, but the potential vascular and suppurative complications may be devastating. We present the 10th reported case of complete extraluminal migration of an esophageal coin, and the only case which was treated without an open surgical procedure. Because of the potential complications, we recommend aggressive surgical intervention as soon as the diagnosis is made. C1 WALTER REED ARMY MED CTR,DEPT SURG,OTOLARYNGOL HEAD & NECK SURG SERV,WASHINGTON,DC 20307. MALCOLM GROW MED CTR,DEPT SURG,OTOLARYNGOL SERV,WASHINGTON,DC. NR 7 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0165-5876 J9 INT J PEDIATR OTORHI JI Int. J. Pediatr. Otorhinolaryngol. PD MAR PY 1992 VL 23 IS 2 BP 187 EP 194 DI 10.1016/0165-5876(92)90056-U PG 8 WC Otorhinolaryngology; Pediatrics SC Otorhinolaryngology; Pediatrics GA HK105 UT WOS:A1992HK10500011 PM 1563936 ER PT J AU LEE, CK SADECK, JE AF LEE, CK SADECK, JE TI CONTROLLED OPENING METHOD FOR CLUSTERED PARACHUTES SO JOURNAL OF AIRCRAFT LA English DT Article AB This paper presents a method for achieving simultaneous opening of clustered parachutes. The method involves connecting and partially reefing the parachutes in a cluster during the initial stage of the opening so that they open together as a single parachute; they are then disconnected and disreefed at almost full inflation, thereby controlling and opening the parachute simultaneously. This method, called the controlled opening method, was tested with clusters of 64-ft-diam G-12 cargo parachutes, 100-ft-diam G-11 cargo parachutes, and 28-ft-diam C-9 personnel parachutes. Their openings were significantly improved when compared to the openings of these clusters without using the controlled opening method. RP LEE, CK (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD MAR-APR PY 1992 VL 29 IS 2 BP 264 EP 272 DI 10.2514/3.46154 PG 9 WC Engineering, Aerospace SC Engineering GA HM898 UT WOS:A1992HM89800015 ER PT J AU VENKATESAN, MM BUYSSE, JM OAKS, EV AF VENKATESAN, MM BUYSSE, JM OAKS, EV TI SURFACE PRESENTATION OF SHIGELLA-FLEXNERI INVASION PLASMID ANTIGENS REQUIRES THE PRODUCTS OF THE SPA LOCUS SO JOURNAL OF BACTERIOLOGY LA English DT Article ID ENTEROINVASIVE ESCHERICHIA-COLI; NUCLEOTIDE-SEQUENCE; MULTIDRUG RESISTANCE; ATP-SYNTHASE; BETA-SUBUNIT; BACTERIAL TRANSPORT; BINDING PROTEINS; P-GLYCOPROTEIN; RHESUS-MONKEYS; GENES AB An avirulent, invasion plasmid insertion mutant of Shigella flexneri 5 (pHS1059) was restored to the virulence phenotype by transformation with a partial HindIII library of the wild-type invasion plasmid constructed in pBR322. Western immunoblot analysis of pHS1059 whole-cell lysates revealed that the synthesis of the invasion plasmid antigens VirG, IpaA, IpaB, IpaC, and IpaD was similar to that seen in the corresponding isogenic S. flexneri 5 virulent strain, M90T. IpaB and IpaC, however, were not present on the surface of pHS1059 as was found in M90T, suggesting that the transport or presentation of the IpaB and IpaC proteins onto the bacterial surface was defective in the mutant. pHS1059 was complemented by pWR266, which carried contiguous 1.2- and 4.1-kb HindIII fragments of the invasion plasmid. pHS1059(pWR266) cells were positive in the HeLa cell invasion assay as well as colony immunoblot and enzyme-linked immunosorbent assays, using monoclonal antibodies to IpaB and IpaC. These studies established that the antigens were expressed on the surface of the transformed bacteria. In addition, water extraction of pHS1059 and pHS1059(pWR266) whole cells, which can be used to remove IpaB and IpaC antigens from the surface of wild-type M90T bacteria, yielded significant amounts of these antigens from pHS1059(pWR266) but not from pHS1059. Minicell and DNA sequence analysis indicated that several proteins were encoded by pWR266, comprising the spa loci, which were mapped to a region approximately 18 kb upstream of the ipaBCDAR gene cluster. Subcloning and deletion analysis revealed that more than one protein was involved in complementing the Spa- phenotype in pHS1059. One of these proteins, Spa47, showed striking homology to ORF4 of the Bacillus subtilis flaA locus and the fliI gene sequence of Salmonella typhimurium, both of which bear strong resemblance to the alpha and beta-subunits of bacterial, mitochondrial, and chloroplast proton-translocating F0F1 ATPases. C1 WALTER REED ARMY MED CTR,DEPT ENTER DIS,WASHINGTON,DC 20307. RP VENKATESAN, MM (reprint author), WALTER REED ARMY MED CTR,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307, USA. NR 54 TC 160 Z9 169 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD MAR PY 1992 VL 174 IS 6 BP 1990 EP 2001 PG 12 WC Microbiology SC Microbiology GA HJ502 UT WOS:A1992HJ50200037 PM 1312536 ER PT J AU MORANG, A AF MORANG, A TI INLET MIGRATION AND HYDRAULIC PROCESSES AT EAST PASS, FLORIDA SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE EBB-TIDAL SHOAL; EROSION; JETTIES; NEARSHORE WAVE MEASUREMENTS; SANTA-ROSA ISLAND; TIDAL HYDRAULICS; TIDAL INLET AB East Pass, a tidal inlet in the Florida Panhandle between Pensacola and Panama City, connects Choctawhatchee Bay to the Gulf of Mexico. From 1983 to 1991, the U.S. Army Corps of Engineers sponsored a monitoring project to measure waves, currents, tidal elevations, bathymetry, and shoreline changes at the site. Based on these data and on historical records, a three-phase model has been developed which describes the inlet's behavior during the last 120 years. The first phase (pre-1928) is of spit development and breaching and covers the period when the pass was oriented in a northwest-southeast direction between Choctawhatchee Bay and the Gulf From 1928 to 1968, the inlet was characterized by the second phase: stable throat position but with a main ebb channel that migrated over a developing ebb-tidal delta. This phase covers the time after the inlet breached through Santa Ross Island in a north-south direction and began to migrate to the east. The third phase, spanning 1968, when rubble-mound jetties were built, to the present is characterized by a stable throat and ebb channel, and ebb-tidal shoal growth. Despite the jetties, East Pass has continued to demonstrate a tendency to move eastward. The driving forces of the eastward migration are hypothesized to be: (1) Wave forces. The predominant wave direction measured in 10-m water depth is from the southwest, while the shoreline trends east-west. (2) Backbay tidal channel and flood-tidal shoal geometry direct ebb currents towards the eastern shore of the inlet. (3) Because of freshwater inputs, the ebb flow is longer in duration and higher in velocity than the flood. RP MORANG, A (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SPR PY 1992 VL 8 IS 2 BP 457 EP 481 PG 25 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA KX286 UT WOS:A1992KX28600018 ER PT J AU CAMFIELD, FE AF CAMFIELD, FE TI REPORT OF THE 55TH MEETING - COASTAL-ENGINEERING-RESEARCH-BOARD SO JOURNAL OF COASTAL RESEARCH LA English DT Editorial Material RP CAMFIELD, FE (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SPR PY 1992 VL 8 IS 2 BP 506 EP 507 PG 2 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA KX286 UT WOS:A1992KX28600023 ER PT J AU PISCITELLE, L SEGARS, R AF PISCITELLE, L SEGARS, R TI EFFECT OF PARTICLE-SIZE DISTRIBUTION IN DETERMINING A POWDERS FRACTAL DIMENSION BY SINGLE GAS BET - A MATHEMATICAL-MODEL SO JOURNAL OF COLLOID AND INTERFACE SCIENCE LA English DT Article ID NONINTEGER DIMENSIONS; CHEMISTRY; SURFACES; IRREGULARITY; PROTEINS C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 11 TC 12 Z9 12 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0021-9797 J9 J COLLOID INTERF SCI JI J. Colloid Interface Sci. PD MAR 1 PY 1992 VL 149 IS 1 BP 226 EP 232 DI 10.1016/0021-9797(92)90407-D PG 7 WC Chemistry, Physical SC Chemistry GA HE420 UT WOS:A1992HE42000024 ER PT J AU SHAW, DS AF SHAW, DS TI COMPUTER-AIDED-INSTRUCTION FOR ADULT PROFESSIONALS - A RESEARCH REPORT SO JOURNAL OF COMPUTER-BASED INSTRUCTION LA English DT Article AB Computer-Aided Instruction (CAI) should satisfy the learning needs of the users. In schools, the goal has been mastery of subject matter. Adult professionals typically need to improve work performance. These different objectives have prompted research on the effectiveness of CAI with architects and engineers The first study found that designers scored as high when they learned a design software package from an embedded computer-based tutorial as they did through more traditional training methods. However, an attitude survey revealed that some features of the tutorial were not considered helpful. Another study identified groups of users who were less satisfied than others with the tutorial. A new instructional system has been modeled that permits more control by adult professionals and can be used to let students learn while working. RP SHAW, DS (reprint author), USA,CONSTRUCT ENGN RES LAB,CECER FSA,POB 9005,CHAMPAIGN,IL 61826, USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU ADCIS INT HEADQUARTERS PI COLUMBUS PA 1601 WEST FIFTH AVE, SUITE 111, COLUMBUS, OH 43212 SN 0098-597X J9 J COMPUT-BASE INSTR PD SPR PY 1992 VL 19 IS 2 BP 54 EP 57 PG 4 WC Education & Educational Research SC Education & Educational Research GA HZ601 UT WOS:A1992HZ60100004 ER PT J AU LAKHANI, H GADE, PA AF LAKHANI, H GADE, PA TI CAREER DECISIONS OF DUAL MILITARY CAREER COUPLES - A MULTIDISCIPLINARY ANALYSIS OF THE UNITED-STATES-ARMY SO JOURNAL OF ECONOMIC PSYCHOLOGY LA English DT Article AB Dual career or two earner couples have been a significant and a growing component of both the civilian and the military labor force. Further, the number of dual military career couples has increased as the number of women in the U.S. Armed Forces has increased. In this paper, we hypothesized that career intentions of these couples were interdependent and a function of variables from economics, psychology, and sociology. Results, based on the 1985 U.S. Army Dual Career Survey, supported this hypothesis. Soldiers' intentions to remain in the U.S. Army were positively related to perceived spouse's intention to stay in the Army, family income, family size, career commitment, and job satisfaction. Policy implications of these results are discussed in the context of military downsizing. RP LAKHANI, H (reprint author), USA,BEHAV & SOCIAL SCI RES INST,PERI RP,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 21 TC 10 Z9 10 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-4870 J9 J ECON PSYCHOL JI J. Econ. Psychol. PD MAR PY 1992 VL 13 IS 1 BP 153 EP 166 DI 10.1016/0167-4870(92)90057-E PG 14 WC Economics; Psychology, Multidisciplinary SC Business & Economics; Psychology GA HP048 UT WOS:A1992HP04800010 ER PT J AU COEN, TJ WONG, M AF COEN, TJ WONG, M TI VARNISHES - THE EFFECT OF A 2ND COAT ON APICAL ROOT LEAKAGE OF RETROFILL AMALGAMS SO JOURNAL OF ENDODONTICS LA English DT Article ID HIGH-COPPER AMALGAM; CAVITY VARNISHES; DENTIN PERMEABILITY; GUTTA-PERCHA; MICROLEAKAGE; EFFICACY; INVITRO AB The root canals of 60 single-rooted human teeth were obturated with gutta-percha. Each root was then resected and randomly received one of five retrofill procedures: copal varnish before the retrofill amalgam; copal varnish before and after the retrofill amalgam; Barrier (polyamide varnish) before the retrofill amalgam; Barrier before and after the retrofill amalgam; or retrofill amalgam with no varnish. All roots were placed in methylene blue dye for 11 days, and apical dye leakage was measured. This study showed that a single coat of either varnish prior to the retrofill improves the apical seal. No statistically significant differences were observed between the use of the two varnishes or between placement of a second coat of either varnish and the use of only one coat. RP COEN, TJ (reprint author), USA,DENT ACT,ADV EDUC GEN DENT PROGRAM,FT HOOD,TX, USA. NR 18 TC 3 Z9 3 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAR PY 1992 VL 18 IS 3 BP 97 EP 99 DI 10.1016/S0099-2399(06)81306-3 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HG194 UT WOS:A1992HG19400001 PM 19186427 ER PT J AU BUDD, CS REID, DE KULILD, JC WELLER, RN AF BUDD, CS REID, DE KULILD, JC WELLER, RN TI ENDODONTIC TREATMENT OF AN UNUSUAL CASE OF FUSION SO JOURNAL OF ENDODONTICS LA English DT Article ID THERAPY AB This case report describes the endodontic and restorative treatment of two anterior permanent teeth with unusual external and internal anatomy due to fusion. A maxillary right central incisor had fused with a supernumerary and the maxillary left central incisor had fused with the left lateral incisor. The complexity of the root canal systems in each tooth required that different endodontic obturation techniques be used. The restorative treatment involved large complex chamber-retained composite build-ups and direct veneers. C1 USA,DENT ACT,POSTGRAD PROGRAM,ENDODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. USA,TINGAY DENT CLIN,FT GORDON,GA 30905. NR 10 TC 7 Z9 7 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAR PY 1992 VL 18 IS 3 BP 133 EP 137 DI 10.1016/S0099-2399(06)81314-2 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HG194 UT WOS:A1992HG19400009 PM 19186435 ER PT J AU BECKETT, DC AARTILA, TP MILLER, AC AF BECKETT, DC AARTILA, TP MILLER, AC TI SEASONAL CHANGE IN PLANT-DWELLING CHIRONOMIDAE AND NAIDIDAE IN A WISCONSIN LAKE SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article ID MACROPHYTES; MACROINVERTEBRATES AB We investigated the degree of change in the larval chironomid and naidid communities colonizing the macrophyte Potamogeton nodosus over the plant's growing season. Sampling of plant-dwelling invertebrates at three sites in Eau Galle Lake, Wisconsin near the beginning of the growing season of P. nodosus (June - 1987) and at the peak of this macrophyte's development (August - 1986 and 1987) revealed dramatic seasonal changes in abundance among the chironomid and naidid species. Non-burrowing chironomid larvae (Paratanytarsus sp., Thienemanniella nr. fusca, and Corynoneura taris) dominated the June collections, whereas burrowing chironomids such as Polypedilum illinoense, Glyptotendipes dreisbachi, and Endochironomus nigricans dominated the August collections in both years. Naidids also showed a marked change from June to August; e.g. Nais pardalis, the most abundant naidid on P. nodosus in June, was not present in the August collections. The striking similarities between the August 1986 and August 1987 invertebrate collections (and their dissimilarities from the June collections) also indicate that these seasonal changes are predictable. It is also apparent that the seasonal succession of chironomid and naidid species produces great temporal diversity, since different species use the same plants at different times. Chironomid and naidid species richness on P. nodosus was considerably greater than has been reported from other studies of plant-dwelling invertebrate communities. C1 USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. RP BECKETT, DC (reprint author), UNIV SO MISSISSIPPI,DEPT BIOL SCI,HATTIESBURG,MS 39406, USA. NR 30 TC 7 Z9 9 U1 0 U2 0 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD MAR PY 1992 VL 7 IS 1 BP 45 EP 57 DI 10.1080/02705060.1992.9664669 PG 13 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA HK695 UT WOS:A1992HK69500006 ER PT J AU EZZELL, JW ABSHIRE, TG AF EZZELL, JW ABSHIRE, TG TI SERUM PROTEASE CLEAVAGE OF BACILLUS-ANTHRACIS PROTECTIVE ANTIGEN SO JOURNAL OF GENERAL MICROBIOLOGY LA English DT Article ID NUCLEOTIDE-SEQUENCE; TOXIN; ENCAPSULATION; GENE; ANTIBODIES; VACCINE; STRAINS; CLONING; PLASMID; REGION AB The protective antigen component of anthrax lethal toxin, produced in vitro, has a molecular mass of 83 kDa. Cell-culture studies by others have demonstrated that upon binding of the 83 kDa protective antigen to cell-surface receptors, the protein is cleaved by an unidentified cell-associated protease activity. The resultant 63 kDa protein then binds lethal factor to form lethal toxin, which has been proposed to be internalized by endocytosis. We found that, in the blood of infected animals, the protective antigen exists primarily as a 63 kDa protein and appears to be complexed with the lethal factor component of the toxin. Conversion of protective antigen from 83 to 63 kDa was catalysed by a calcium-dependent, heat-labile serum protease. Except for being complexed to protective antigen, there was no apparent alteration of lethal factor during the course of anthrax infection. The protective antigen-cleaving protease appeared to be ubiquitous among a wide range of animal species, including primates, horses, goats, sheep, dogs, cats and rodents. RP EZZELL, JW (reprint author), USA,MED RES INST INFECT DIS,DIV BACTERIOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 44 TC 64 Z9 67 U1 0 U2 0 PU SOC GENERAL MICROBIOLOGY PI READING PA HARVEST HOUSE 62 LONDON ROAD, READING, BERKS, ENGLAND RG1 5AS SN 0022-1287 J9 J GEN MICROBIOL JI J. Gen. Microbiol. PD MAR PY 1992 VL 138 BP 543 EP 549 PN 3 PG 7 WC Microbiology SC Microbiology GA HH673 UT WOS:A1992HH67300018 PM 1593265 ER PT J AU XIAO, SY CHU, YK KNAUERT, FK LOFTS, R DALRYMPLE, JM LEDUC, JW AF XIAO, SY CHU, YK KNAUERT, FK LOFTS, R DALRYMPLE, JM LEDUC, JW TI COMPARISON OF HANTAVIRUS ISOLATES USING A GENUS-REACTIVE PRIMER PAIR POLYMERASE CHAIN-REACTION SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID KOREAN HEMORRHAGIC-FEVER; NEPHROPATHIA EPIDEMICA VIRUS; RENAL SYNDROME; HANTAAN VIRUS; UNITED-STATES; NUCLEOTIDE-SEQUENCE; ETIOLOGIC AGENT; RAT; RNA; ANTIBODY AB RNA of more than 40 hantavirus isolates, originating from rodents and humans of widely separated geographical areas, was copied to cDNA using reverse transcriptase and amplified by polymerase chain reaction (PCR). A genus-reactive oligonucleotide primer pair, flanking a 365 bp region of the G2 glycoprotein gene, was chosen for genus-reactive PCR. DNA products were digested with 20 restriction endonucleases and cleavage patterns were analysed. For strains of known sequence, the restriction patterns observed were consistent with those predicted from sequence data, demonstrating that the amplified products originated from target virus RNA. Further analyses suggested that all amplified viruses could be easily typed into one of five restriction patterns using only five enzymes. The categories identified by restriction analysis of PCR-amplified cDNA corresponded with serogroups established by plaque-reduction neutralization tests. This method may greatly simplify the identification of new hantavirus isolates. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. RP XIAO, SY (reprint author), USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FT DETRICK,BLDG 1425,FREDERICK,MD 21702, USA. NR 38 TC 50 Z9 58 U1 4 U2 5 PU SOC GENERAL MICROBIOLOGY PI READING PA HARVEST HOUSE 62 LONDON ROAD, READING, BERKS, ENGLAND RG1 5AS SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD MAR PY 1992 VL 73 BP 567 EP 573 PN 3 PG 7 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA HH456 UT WOS:A1992HH45600009 PM 1347558 ER PT J AU ESHOW, MM AF ESHOW, MM TI FLIGHT INVESTIGATION OF VARIATIONS IN ROTORCRAFT CONTROL AND DISPLAY DYNAMICS FOR HOVER SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article AB This paper describes a flight investigation of the handling qualities issues associated with variations in display dynamics for varying levels of vehicle augmentation. The experiment was conducted on the NASA/Army CH-47B Variable-Stability Research Helicopter using its model-following control system and a color, panel-mounted display. A display law design method developed and flight tested previously was refined and expanded to account for guidance effects. Specifically, for rate, attitude, and velocity command vehicle response types, both integrator-like and gain-like display controlled element dynamics were evaluated in two hovering tasks conducted in simulated zero-visibility conditions. The tasks were performed both with and without automation of the vertical and directional axes to assess the impact of divided attention on performance and work load. Quantitative and subjective data describing the pilots' ability to perform the tasks were collected and analyzed, and pilot-vehicle-display dynamics were identified. Results indicated that gain-like display dynamics were generally preferred and resulted in better inner-loop tracking and higher inner-loop crossover frequencies, while not degrading outer-loop position performance. RP ESHOW, MM (reprint author), USA,NASA,AMES RES CTR,ARMY AEROFLIGHT DYNAM DIRECTORATE,FLIGHT CONTROL BRANCH,AVIAT SYST COMMAND,MOFFETT FIELD,CA 94035, USA. NR 19 TC 1 Z9 1 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD MAR-APR PY 1992 VL 15 IS 2 BP 482 EP 490 DI 10.2514/3.20861 PG 9 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA HK051 UT WOS:A1992HK05100026 ER PT J AU LETTERIE, GS LUETKEHANS, T AF LETTERIE, GS LUETKEHANS, T TI REPRODUCTIVE OUTCOME AFTER FALLOPIAN-TUBE CANALIZATION AND MICROSURGERY FOR BIPOLAR TUBAL OCCLUSION SO JOURNAL OF GYNECOLOGIC SURGERY LA English DT Article AB Surgical therapy for coexistent proximal and distal obstruction has consisted of combined proximal (reimplantation or reanastomosis) and distal (salpingostomy) repairs. Data suggest that successful relief of proximal obstruction by fluoroscopically guided tubal canalization (FTC) may be achieved in 60% to 95% of cases. We studied the use of FTC as a preoperative adjunct in 14 patients with coexistent proximal tubal obstruction (PTO) and distal tubal obstruction, progressing to surgical repair of distal disease if proximal patency was achieved. Unilateral (9/14) or bilateral (5/14) PTO was demonstrated on at least one hysterosalpingogram (HSG) and during chromotubation performed as part of the diagnostic laparoscopy. FTC was successful in four patients (28%). HSG revealed proximal reocclusion in two patients. Two patients had persistent proximal patency and underwent distal salpingostomies and adhesiolysis for mild hydrosalpinges and pelvic adhesive disease. No pregnancies have been achieved after 12 and 18 months follow-up. The lower patency rate and higher recurrence rates of PTO when compared to data of prior studies suggest that in vitro fertilization, though more costly, ultimately may represent the most expedient and effective method of management of coexistent proximal and distal tubal disease. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859. NR 6 TC 4 Z9 4 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1042-4067 J9 J GYNECOL SURG JI J. Gynecol. Surg. PD SPR PY 1992 VL 8 IS 1 BP 11 EP 13 DI 10.1089/gyn.1992.8.11 PG 3 WC Obstetrics & Gynecology; Surgery SC Obstetrics & Gynecology; Surgery GA HX250 UT WOS:A1992HX25000002 PM 10149786 ER PT J AU CULLINANE, MJ LANSEY, KE MAYS, LW AF CULLINANE, MJ LANSEY, KE MAYS, LW TI OPTIMIZATION-AVAILABILITY-BASED DESIGN OF WATER-DISTRIBUTION NETWORKS SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article ID DISTRIBUTION-SYSTEM DESIGN; RELIABILITY; MODEL AB A practical measure for water-distribution system reliability, based on hydraulic availability is presented and incorporated in an optimal design procedure for component sizing. The measure combines hydraulic and mechanical availability in a form that defines the proportion of the time that the system will satisfactorily fulfill its function. However, rather than a simple discrete failure relationship with absolute failure it pressure heads fall below a prescribed minimum the hydraulic availability is modeled with continuous increasing acceptability as higher pressures occur. Availability is considered in a nonlinear optimization model that is reduced in complexity by linking the optimizer with a network solver to implicitly solve the hydraulic constraints. The results of the model application show an increasing marginal cost for higher levels of availability, and the optimal designs tend to follow the engineering rules of thumb for system design. C1 UNIV ARIZONA,DEPT CIVIL ENGN & ENGN MECH,TUCSON,AZ 85721. ARIZONA STATE UNIV,DEPT CIVIL ENGN,TEMPE,AZ 85287. RP CULLINANE, MJ (reprint author), USA,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 30 TC 80 Z9 87 U1 2 U2 7 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD MAR PY 1992 VL 118 IS 3 BP 420 EP 441 DI 10.1061/(ASCE)0733-9429(1992)118:3(420) PG 22 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA HE637 UT WOS:A1992HE63700006 ER PT J AU NAVIN, TR ARANA, BA ARANA, FE BERMAN, JD CHAJON, JF AF NAVIN, TR ARANA, BA ARANA, FE BERMAN, JD CHAJON, JF TI PLACEBO-CONTROLLED CLINICAL-TRIAL OF SODIUM STIBOGLUCONATE (PENTOSTAM) VERSUS KETOCONAZOLE FOR TREATING CUTANEOUS LEISHMANIASIS IN GUATEMALA SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID STEROL BIOSYNTHESIS; ANTILEISHMANIAL AGENTS; MEXICANA PROMASTIGOTES; EFFICACY; AMASTIGOTES; MACROPHAGES; GROWTH AB To determine the relative efficacy and toxicity of stibogluconate and ketoconazole for the treatment of cutaneous leishmaniasis, a comparative trial was conducted in which 120 Guatemalan men with parasitologically proven cutaneous leishmaniasis were randomly divided into three treatment groups: sodium stibogluconate (20 mg of antimony per kilogram per day intravenously for 20 days), ketoconazole (600 mg per day orally for 28 days), and placebo. Treatment outcome was influenced by species. Among patients infected with Leishmania braziliensis, 24 (96%) of 25 in the stibogluconate group but only 7 (30%) of 23 in the ketoconazole group responded. Among Leishmania mexicana-infected patients, only 4 (57%) of 7 in the stibogluconate group but 8 (89%) of 9 in the ketoconazole group responded. These differences emphasize the importance of speciation in the treatment of leishmaniasis. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. SANIDAD MIL,GUATEMALA CITY,GUATEMALA. RP NAVIN, TR (reprint author), CTR DIS CONTROL,CTR INFECT DIS,DIV PARASIT DIS,MED ENTOMOL RES & TRAINING UNIT GUATEMALA,ATLANTA,GA 30333, USA. NR 17 TC 196 Z9 201 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAR PY 1992 VL 165 IS 3 BP 528 EP 534 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HE466 UT WOS:A1992HE46600018 PM 1311351 ER PT J AU PETRUCCELLI, BP MURPHY, GS SANCHEZ, JL WALZ, S DEFRAITES, R GELNETT, J HABERBERGER, RL ECHEVERRIA, P TAYLOR, DN AF PETRUCCELLI, BP MURPHY, GS SANCHEZ, JL WALZ, S DEFRAITES, R GELNETT, J HABERBERGER, RL ECHEVERRIA, P TAYLOR, DN TI TREATMENT OF TRAVELERS DIARRHEA WITH CIPROFLOXACIN AND LOPERAMIDE SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID CAMPYLOBACTER-JEJUNI AB To determine the efficacy of loperamide given with long- and short-course quinolone therapy for treating traveler's diarrhea, 142 US military personnel were randomized to receive a single 750-mg dose of ciprofloxacin with placebo, 750 mg of ciprofloxacin with loperamide, or a 3-day course of 500 mg of ciprofloxacin twice daily with loperamide. Culture of pretreatment stool specimens revealed campylobacters (41%), salmonellae (18%), enterotoxigenic Escherichia coli (ETEC, 6%), and shigellae (4%). Of the participants, 87% completely recovered within 72 h of entry. Total duration of illness did not differ significantly among the three treatment groups, but patients in the 3-day ciprofloxacin plus loperamide group reported a lower cumulative number of liquid bowel movements at 48 and 72 h after enrollment compared with patients in the single-dose ciprofloxacin plus placebo group (1.8 vs. 3.6, P = .01; 2.0 vs. 3.9, P = .01). While not delivering a remarkable therapeutic advantage, loperamide appears to be safe for treatment of non-ETEC causes of traveler's diarrhea. Two of 54 patients with Campylobacter enteritis had a clinical relapse after treatment that was associated with development of ciprofloxacin resistance. C1 WALTER REED ARMY MED CTR,DEPT ENTER INFECT,DIV PREVENT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV COMMUN DIS & IMMUNOL,WASHINGTON,DC 20307. MADIGAN ARMY MED CTR,PREVENT MED SERV,FT LEWIS,MD. USN,INST MED RES,BETHESDA,MD 20814. ARMED FORCES RES INST MED SCI,DEPT BACTERIOL,BANGKOK,THAILAND. USN,MED RES UNIT 2,MANILA,PHILIPPINES. NR 12 TC 111 Z9 111 U1 1 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAR PY 1992 VL 165 IS 3 BP 557 EP 560 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HE466 UT WOS:A1992HE46600024 PM 1538160 ER PT J AU QIAN, CG LIU, CT PETERS, CJ AF QIAN, CG LIU, CT PETERS, CJ TI METABOLISM OF PLATELET-ACTIVATING-FACTOR IN NEUTROPHILS ISOLATED FROM PICHINDE VIRUS-INFECTED GUINEA-PIGS SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE LYSOPLATELET-ACTIVATING FACTOR; ACYLPLATELET-ACTIVATING FACTOR; LEUKOPENIA ID FACTOR PAF; INTRAVENOUS-INFUSION; ANTAGONIST; MEDIATORS; RESPONSES; ACETHER; LIPIDS AB Metabolism of platelet-activating factor (PAF) was studied in cultured polymorphonuclear neutrophils (PMNs) obtained from Pichinde virus-infected strain 13 guinea pigs. Neutrophils obtained from control and infected guinea pigs on postinoculation days 10 and 14 were incubated with [H-3]lyso-PAF, [H-3]PAF, or [H-3]acetate. After incubation for 1 h at 37-degrees-C, formation of [H-3]acyl-PAF from either [H-3]lyso-PAF or [H-3]PAF increased significantly in PMNs from infected guinea pigs compared to control PMNs. Furthermore, total radioactivity from [H-3]lyso-PAF or [H-3]PAF was higher in PMNs from infected animals than in those from controls. However, compared to PAF production by control PMNs, production of PAF by infected PMNs was unchanged. These results suggest that PMNs may not be the major source of increased blood PAF levels during Pichinde viral disease. C1 USA,MED RES INST INFECT DIS,DEPT CLIN & EXPTL PHYSIOL,DIV DIS ASSESSMENT,FREDERICK,MD 21701. NR 20 TC 2 Z9 2 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD MAR PY 1992 VL 51 IS 3 BP 210 EP 213 PG 4 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA JQ363 UT WOS:A1992JQ36300002 PM 1541904 ER PT J AU ROBERT, LL COLEMAN, RE LAPOINTE, DA MARTIN, PJS KELLY, R EDMAN, JD AF ROBERT, LL COLEMAN, RE LAPOINTE, DA MARTIN, PJS KELLY, R EDMAN, JD TI LABORATORY AND FIELD-EVALUATION OF 5 REPELLENTS AGAINST THE BLACK FLIES PROSIMULIUM-MIXTUM AND P-FUSCUM (DIPTERA, SIMULIIDAE) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE INSECTA; PROSIMULIUM; REPELLENTS; DEET ID TRIALS; DEET AB Deet (N,N-diethyl-3-methylbenzamide), the lactone CIC-4 ([2-hydroxy-methyl-cyclohexyl] acetic acid lactone), the USDA Proprietary Chemicals AI3-37220 (1-[3-cyclohexen-1-ylcarbonyl]-2-methylpiperidine) and AI3-35765 (1-[3-cyclohexen-1-ylcarbonyl] piperidine), and the U.S. military extended duration repellent formulation (EDRF) of deet were evaluated for repellency in the laboratory and field against the black flies Prosimulium mixtum and P. fuscum. CIC-4, AI3-37220, and AI3-35765 were as effective as deet at repelling P. mixtum and P. fuscum in laboratory and field experiments. Only the EDRF provided significantly longer protection than the deet standard against these black flies in the field. C1 UNIV MASSACHUSETTS,DEPT ENTOMOL,AMHERST,MA 01003. RP ROBERT, LL (reprint author), WALTER REED ARMY MED CTR,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 27 TC 23 Z9 24 U1 0 U2 1 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAR PY 1992 VL 29 IS 2 BP 267 EP 272 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA HG772 UT WOS:A1992HG77200021 PM 1495040 ER PT J AU LINTHICUM, KJ DICKSON, DL LOGAN, TM AF LINTHICUM, KJ DICKSON, DL LOGAN, TM TI FEEDING EFFICIENCY OF LARVAL HYALOMMA-TRUNCATUM (ACARI, IXODIDAE) ON HOSTS PREVIOUSLY EXPOSED TO TICKS SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ARACHNIDA; IXODIDAE; HYALOMMA-TRUNCATUM; HOST RESPONSE ID GUINEA-PIGS; IMMUNE RESISTANCE; PASSIVE TRANSFER; IDENTIFICATION; ANTIGENS AB The effect of guinea pig response to feeding larval Hyalomma truncatum Koch ticks was studied by measuring the percentage of ticks engorging and molting, their engorged weight, and hemoglobin content. Four guinea pigs were infested with 100, 200, 400, and 1,000 larvae, respectively, on three occasions at 21-d intervals, followed by a fourth infestation with 500 larvae. During the second, third, and fourth infestations, significantly fewer ticks engorged on each guinea pig than during the first infestation. The greatest reduction in percentage molting occurred during the fourth infestation on the animal with successive exposure to 400 larvae; only 24% of the ticks that fed molted. Ticks with the lowest mean weight and hemoglobin content also engorged on this animal during the fourth infestation. Guinea pigs exposed to 200 and 400 H. truncatum larvae elicited the greatest change in feeding efficiency during the fourth infestation. However, these hosts had no effect on a single subsequent fifth infestation with Amblyomma cajennense (F.) nymphs, as > 95% successfully engorged. RP LINTHICUM, KJ (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,DEPT ARBOVIRAL ENTOMOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 21 TC 3 Z9 3 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAR PY 1992 VL 29 IS 2 BP 310 EP 313 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA HG772 UT WOS:A1992HG77200029 PM 1495048 ER PT J AU LIN, WW KIANG, JG CHUANG, DM AF LIN, WW KIANG, JG CHUANG, DM TI PHARMACOLOGICAL CHARACTERIZATION OF ENDOTHELIN-STIMULATED PHOSPHOINOSITIDE BREAKDOWN AND CYTOSOLIC FREE CA-2+ RISE IN RAT C6 GLIOMA-CELLS SO JOURNAL OF NEUROSCIENCE LA English DT Article ID VASCULAR SMOOTH-MUSCLE; VASOACTIVE INTESTINAL CONTRACTOR; CEREBELLAR GRANULE CELLS; INOSITOL TRISPHOSPHATE; CALCIUM-CONCENTRATION; PHOSPHATE FORMATION; PEPTIDE ENDOTHELIN; DOWN-REGULATION; ANGIOTENSIN-II; NG108-15 CELLS AB Because increasing evidence indicates that glial cells are a target of endothelin, we have characterized endothelin-induced phosphoinositide (PI) turnover and Ca2+ homeostasis in C6 glioma cells. Endothelin-1 (ET) increased formation of H-3-inositol phosphate (IP) from PI and elicited an increase in cytosolic free Ca2+ ([Ca2+]i) in rat C6 glioma. In the presence of Li+, the increase in H-3-inositol trisphosphate formation was rapid, reaching its peak at 5 min after stimulation. ET also elicited a rapid and sustained increase in [Ca2+]i in a dose-dependent manner (1-100 nM). The rank orders of efficacy for ET-related peptides in increasing [Ca2+]i were ET = ET-2 > sarafotoxin > ET-3. Both ET-mediated stimulation of IP formation and [Ca2+]i increase were largely inhibited in the absence of external Ca2+ but unaffected by the depletion of external Na+ and the presence of dihydropyridine derivatives or verapamil. Inorganic Ca2+ channel blockers Cd2+, La3+, and Mn2+ at 1 mM inhibited both responses induced by ET. Cross-desensitization and nonadditivity were observed for both events among ET-related peptides tested, but not between ET and ATP. Pretreatment of cells with pertussis toxin (PTX) attenuated the PI response to ET, but had no effect on ET-elicited [Ca2+]i increase. ET-induced Ca2+ mobilization (measured in Ca2+-free medium) was only transient and was inhibited by 8-(N,N-diethylamino)octyl-3,4,5-trimethoxy-benzoate. Moreover, the intracellular Ca2+ pools mobilized by ET and ATP appeared to overlap, as indicated by their partial heterologous desensitization. Pretreatment with phorbol dibutyrate (PDBu) for 10 min reduced the PI response and Ca2+ mobilization but potentiated the [Ca2+]i increase induced by ET. In cells pretreated with PDBu for 24 hr, both responses to ET were attenuated. Our results suggest that, in C6 glioma, ET induces PI hydrolysis and causes Ca2+ influx. The former response is mediated by a PTX-sensitive G-protein, leading to intracellular Ca2+ mobilization, while the latter response results in further increase in [Ca2+]i. C1 NIMH,BIOL PSYCHIAT BRANCH,CHIEF UNIT MOLEC NEUROBIOL,BLDG 10,ROOM 3N212,BETHESDA,MD 20892. NATL TAIWAN UNIV,COLL MED,DEPT PHARMACOL,TAIPEI,TAIWAN. WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307. OI Lin, Wan Wan/0000-0002-3207-734X NR 49 TC 47 Z9 47 U1 0 U2 0 PU SOC NEUROSCIENCE PI WASHINGTON PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 SN 0270-6474 J9 J NEUROSCI JI J. Neurosci. PD MAR PY 1992 VL 12 IS 3 BP 1077 EP 1085 PG 9 WC Neurosciences SC Neurosciences & Neurology GA HJ353 UT WOS:A1992HJ35300036 PM 1312133 ER PT J AU MAEL, F ASHFORTH, BE AF MAEL, F ASHFORTH, BE TI ALUMNI AND THEIR ALMA-MATER - A PARTIAL TEST OF THE REFORMULATED MODEL OF ORGANIZATIONAL IDENTIFICATION SO JOURNAL OF ORGANIZATIONAL BEHAVIOR LA English DT Article ID SOCIAL IDENTITY; COMMITMENT; BEHAVIOR; MEMBERS; BIAS AB Organizational identification is defined as a perceived oneness with an organization and the experience of the organization's successes and failures as one's own. While identification is considered important to the organization, it has not been clearly operationalized. The current study tests a proposed model of organizational identification. Self-report data from 297 alumni of an all-male religious college indicate that identification with the alma mater was associated with: (1) the hypothesized organizational antecedents of organizational competition, but not with interorganizational competition, (2) the hypothesized individual antecedents of satisfaction with the organization, tenure as students, and sentimentality, but not with recency of attendance, number of schools attended, or the existence of a mentor, and (3) the hypothesized outcomes of making financial contributions, willingness to advise one's offspring and others to attend the college, and participating in various school functions. The findings provide direction for academic administrators seeking to increase alumni support, as well as for corporate managers concerned about the loyalty of workers in an era of mergers and takeovers. C1 CONCORDIA UNIV,DEPT MANAGEMENT,MONTREAL H3G 1M8,QUEBEC,CANADA. RP MAEL, F (reprint author), USA,RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 79 TC 1141 Z9 1182 U1 33 U2 198 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0894-3796 J9 J ORGAN BEHAV JI J. Organ. Behav. PD MAR PY 1992 VL 13 IS 2 BP 103 EP 123 DI 10.1002/job.4030130202 PG 21 WC Business; Psychology, Applied; Management SC Business & Economics; Psychology GA HM685 UT WOS:A1992HM68500001 ER PT J AU LONG, JB RIGAMONTI, DD DOSAKA, K KRAIMER, JM MARTINEZARIZALA, A AF LONG, JB RIGAMONTI, DD DOSAKA, K KRAIMER, JM MARTINEZARIZALA, A TI SOMATOSTATIN CAUSES VASOCONSTRICTION, REDUCES BLOOD-FLOW AND INCREASES VASCULAR-PERMEABILITY IN THE RAT CENTRAL-NERVOUS-SYSTEM SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID SPINAL SUBARACHNOID INJECTION; BRAIN-BARRIER PERMEABILITY; DYNORPHIN-A 1-13; SUBSTANCE-P; INTRATHECAL SOMATOSTATIN; DORSAL HORN; NEUROLOGICAL DYSFUNCTION; RECEPTOR ANTAGONIST; NEUROTOXIC ACTIONS; NEURONAL INJURY AB Using radiolabeled microspheres, spinal cord blood flow was measured after spinal subarachnoid injections of 3.1- to 12.5-nmol doses of somatostatin through either indwelling i.t. catheters or acutely inserted intervertebral needles. With either injection technique, somatostatin caused significant dose-dependent reductions in thoracic and lumbosacral blood flow that could be partially blocked by a 5-min preinjection of the somatostatin receptor antagonist cyclo[7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)], which has previously been shown to block the hindlimb flaccidity produced by these doses of somatostatin in conscious rats. The duration of these blood flow changes were appreciably less in the rats injected through indwelling i.t. catheters. Somatostatin-induced reductions in spinal cord perfusion were accompanied by transient pressor responses, reduced cardiac output, 3-fold increases in spinal cord cerebrospinal fluid lactic acid concentrations and breakdown of the blood-spinal cord barrier, as reflected by significantly increased extravasation of [I-125]bovine serum albumin. By 24 hr postinjection, a 12.5-nmol dose of somatostatin caused appreciable spinal cord cellular injury, as evidenced by significant elevations in cerebrospinal fluid concentrations of lactate dehydrogenase. After topical application to exposed pial vessels of the parietal cortex, comparable doses of somatostatin caused immediate intense dose-related arteriolar vasospasm and subsequent extravasation of the visible macromolecular tracer Evans blue dye. We conclude that somatostatin has significant vasoconstrictory effects on the blood vessels of the brain and spinal cord of the rat that must be recognized and appreciated when studying its neuropharmacological actions in vivo. C1 WALTER REED ARMY MED CTR,DIV SURG,WASHINGTON,DC 20307. UNIV MIAMI,SCH MED,MIAMI,FL 33152. RP LONG, JB (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,NEUROPHARMACOL BRANCH,WASHINGTON,DC 20307, USA. NR 44 TC 36 Z9 36 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD MAR PY 1992 VL 260 IS 3 BP 1425 EP 1432 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA HJ019 UT WOS:A1992HJ01900069 PM 1347570 ER PT J AU HOMIAK, AW COOK, PA DEBOER, J AF HOMIAK, AW COOK, PA DEBOER, J TI EFFECT OF HYGIENE INSTRUMENTATION ON TITANIUM ABUTMENTS - A SCANNING ELECTRON-MICROSCOPY STUDY SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID POWDER ABRASIVE INSTRUMENT; PROPHY-JET; REMOVAL; INVITRO; SYSTEM AB Implant abutments can be exposed to a variety of oral prophylaxis procedures. In this in vitro study, titanium abutments were subjected to five oral prophylaxis treatment modalities; a metal scaler, a plastic scaler, a rubber cup, a rubber cup with tin oxide, and an air-powder abrasive. The abutment surfaces were then examined under both light and scanning electron microscopes. The metal scaler was seen to roughen the titanium surface. All other modalities tested appeared to smooth the titanium surface by removing surface debris and rounding off the sharp machined grooves present on the untreated abutment surface. C1 USA DENT ACT,PROSTHODONT RESIDENCY TRAINING PROGRAM,FT BLISS,TX. NR 15 TC 24 Z9 24 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAR PY 1992 VL 67 IS 3 BP 364 EP 369 DI 10.1016/0022-3913(92)90248-9 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HF661 UT WOS:A1992HF66100018 PM 1324308 ER PT J AU DRISCOLL, CF TAYLOR, MA OSTROWSKI, JS AF DRISCOLL, CF TAYLOR, MA OSTROWSKI, JS TI FABRICATION OF BOLUS COMPENSATORS USED IN THE TREATMENT OF IRREGULAR TISSUE SURFACES IN RADIATION-THERAPY SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID COMPLICATIONS; PREVENTION AB Radiation treatment involving irregular surfaces of facial topography often causes difficulties for the radiation oncologists. The isodose curves normally used become skewed, thereby making treatment planning more complex. A simple and useful technique is presented describing the use of dental materials to make a bolus compensator to aid in radiation therapy of nonplanar surfaces. This technique will allow the radiation oncologist to treat these patients in a most efficient manner. The materials needed are readily available to the dentist and are easily handled. C1 NATL NAVAL DENT SCH, BETHESDA, MD USA. NATL NAVAL MED CTR, BETHESDA, MD 20814 USA. RP DRISCOLL, CF (reprint author), USA, DENTAC, TRIPLER ARMY MED CTR, HONOLULU, HI 96859 USA. NR 22 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAR PY 1992 VL 67 IS 3 BP 370 EP 374 DI 10.1016/0022-3913(92)90249-A PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HF661 UT WOS:A1992HF66100019 PM 1507103 ER PT J AU MCCARTNEY, JW AF MCCARTNEY, JW TI MANAGEMENT OF IMPLANT MALALIGNMENT PRECLUDING TRANSFER COPING PLACEMENT SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article RP MCCARTNEY, JW (reprint author), WALTER REED ARMY MED CTR,AREA DENT LAB,WASHINGTON,DC 20307, USA. NR 1 TC 3 Z9 3 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAR PY 1992 VL 67 IS 3 BP 423 EP 425 DI 10.1016/0022-3913(92)90263-A PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HF661 UT WOS:A1992HF66100033 PM 1507116 ER PT J AU CAMPBELL, TM NAGY, WW AF CAMPBELL, TM NAGY, WW TI CYANOACRYLATE ACCELERATOR FOR DIE PREPARATION SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article C1 USA,DENT ACT,DEPT FIXED PROSTHODONT,FT SAM HOUSTON,TX 78234. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAR PY 1992 VL 67 IS 3 BP 427 EP 427 DI 10.1016/0022-3913(92)90265-C PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HF661 UT WOS:A1992HF66100035 PM 1507118 ER PT J AU BLOODWORTH, KE AF BLOODWORTH, KE TI IMPROVEMENT IN AN ARTICULATORS CLUTCH FABRICATION SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article RP BLOODWORTH, KE (reprint author), USA,DENT ACT,FT ORD,CA 93941, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAR PY 1992 VL 67 IS 3 BP 428 EP 428 DI 10.1016/0022-3913(92)90266-D PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HF661 UT WOS:A1992HF66100036 PM 1507119 ER PT J AU BLOODWORTH, KE AF BLOODWORTH, KE TI IMPROVEMENTS IN AN ARTICULATOR CLUTCH DESIGN AND REGISTRATION SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article C1 USA,DENT ACT,FT ORD,CA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAR PY 1992 VL 67 IS 3 BP 429 EP 429 DI 10.1016/0022-3913(92)90267-E PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HF661 UT WOS:A1992HF66100037 PM 1507120 ER PT J AU BORNSTEIN, J CELMINS, I PLOSTINS, P SCHMIDT, E AF BORNSTEIN, J CELMINS, I PLOSTINS, P SCHMIDT, E TI LAUNCH DYNAMICS OF FIN-STABILIZED PROJECTILES SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article AB An experimental methodology examining the disturbances acting upon fin-stabilized projectiles during the launch process and initial stages of free flight has been developed. Disturbances are characterized by the angular deviation of the projectile trajectory from an anticipated line of flight extending between the gun muzzle and the aim point prior to firing the cannon. Gun motion during projectile in-bore time is determined using strain gauges and proximity probes. A technique employing multiple orthogonal x rays is used to measure both the linear and angular motion of the projectile during the transitional ballistic flight phase. Radiographs taken in the immediate vicinity of the muzzle provide the relative motion of the projectile with respect to the muzzle caused by inbore balloting, gun/projectile decoupling, initial sabot discard, and muzzle blast disturbances. Comparison with radiographs obtained after sabot separation measures the disturbances due to asymmetric sabot discard. Results obtained using these techniques have shown that the gun dynamics contributes less than half of the overall disturbance to the projectile, but the in-bore vibration of the projectile is a major contributor, as is asymmetric sabot discard. RP BORNSTEIN, J (reprint author), USA,BALLIST RES LAB,DIV LAUNCH & FLIGHT,FLUID PHYS LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 10 TC 4 Z9 4 U1 1 U2 2 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD MAR-APR PY 1992 VL 29 IS 2 BP 166 EP 172 DI 10.2514/3.26331 PG 7 WC Engineering, Aerospace SC Engineering GA HM954 UT WOS:A1992HM95400004 ER PT J AU SWAB, JJ LEATHERMAN, GL AF SWAB, JJ LEATHERMAN, GL TI STATIC-FATIGUE LIFE OF CE-TZP AND SI3N4 IN A CORROSIVE ENVIRONMENT SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Note ID MOLTEN-SALT CORROSION; SILICON-NITRIDE; HOT CORROSION; SODIUM-SULFATE; CERAMICS; STRENGTH AB Stress rupture testing was performed in four-point flexure at 1000-degrees-C to determine the effects of Na2SO4-induced corrosion on the static-fatigue life of a Ce-TZP and a MgO-doped Si3N4. The results showed that the static-fatigue life of the Ce-TZP was unaffected by this corrosive environment. However, the static-fatigue life of a MgO-doped Si3N4 was reduced by the introduction of Na2SO4. C1 WORCESTER POLYTECH INST,WORCESTER,MA 01609. RP SWAB, JJ (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 25 TC 1 Z9 1 U1 0 U2 0 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD MAR PY 1992 VL 75 IS 3 BP 719 EP 721 DI 10.1111/j.1151-2916.1992.tb07866.x PG 3 WC Materials Science, Ceramics SC Materials Science GA HJ063 UT WOS:A1992HJ06300037 ER PT J AU LOGAN, TM LINTHICUM, KJ AF LOGAN, TM LINTHICUM, KJ TI SURVIVAL OF AEDES (NEOMELANICONION) EGGS IN THE LABORATORY SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Note ID VALLEY FEVER VIRUS; KENYA AB Adult Aedes mcintoshi and Ae. circumluteolus were produced from eggs stored up to 9 months in the laboratory. Under standard hatching conditions, eggs stored at 24-degrees and 26-degrees-C consistently produced adults for up to 9 months after collection. In contrast, eggs stored at 15-degrees-C were significantly different, producing < 1% adults from 6-12 months after collection. Aedes (Neomelaniconion) eggs can be stored and serve as a reliable source of specimens to be used in vector competence and other studies. RP LOGAN, TM (reprint author), USA,MED RES INST INFECT DIS,FREDERICK,MD 21702, USA. NR 11 TC 1 Z9 1 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1992 VL 8 IS 1 BP 89 EP 91 PG 3 WC Entomology SC Entomology GA HM114 UT WOS:A1992HM11400018 PM 1583498 ER PT J AU TURELL, MJ DICKSON, DL AF TURELL, MJ DICKSON, DL TI RECOVERABILITY OF RIFT-VALLEY FEVER AND SANDFLY FEVER SICILIAN VIRUSES FROM INFECTED PHLEBOTOMUS-PAPATASI (DIPTERA, PSYCHODIDAE) TRAPPED IN VARIOUS OILS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Note ID FLIES AB We studied the effects of various oils used to trap sand flies on the recovery of virus from infected adult Phlebotomus papatasi. Both Rift Valley fever and sandfly fever Sicilian viruses were readily recovered from virus-inoculated specimens held at 26-degrees-C on mineral, olive or castor oil-soaked sheets for up to 12 h. However, after 50 h on oil-soaked paper, significantly greater titers were recovered from sand flies trapped with mineral oil than from sand flies trapped with either of the other oils. This indicates that sand flies trapped on oil-soaked paper would be suitable for virus isolation attempts and that mineral oil had the least effect on virus recovery. RP TURELL, MJ (reprint author), USA,MED RES INST INFECT DIS,DEPT ARBOVIRAL ENTOMOL,DIV VIROL,FREDERICK,MD 21702, USA. NR 12 TC 1 Z9 1 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1992 VL 8 IS 1 BP 92 EP 94 PG 3 WC Entomology SC Entomology GA HM114 UT WOS:A1992HM11400019 PM 1316427 ER PT J AU ALM, PF AF ALM, PF TI VETERINARY SERVICE IN POSTWAR KUWAIT SO JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Article; Proceedings Paper CT ANIMAL WELFARE FORUM : THE VETERINARIANS ROLE IN THE WELFARE OF WILDLIFE CY NOV 07, 1991 CL CHICAGO, IL SP AMER VET MED ASSOC C1 USA,VET CORPS,SAN ANTONIO,TX 78247. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 SN 0003-1488 J9 J AM VET MED ASSOC JI J. Am. Vet. Med. Assoc. PD MAR 1 PY 1992 VL 200 IS 5 BP 640 EP 641 PG 2 WC Veterinary Sciences SC Veterinary Sciences GA HF684 UT WOS:A1992HF68400012 PM 1568902 ER PT J AU WARREN, WL POINDEXTER, EH OFFENBERG, M MULLERWARMUTH, W AF WARREN, WL POINDEXTER, EH OFFENBERG, M MULLERWARMUTH, W TI PARAMAGNETIC POINT-DEFECTS IN AMORPHOUS-SILICON DIOXIDE AND AMORPHOUS-SILICON NITRIDE THIN-FILMS .1. A-SIO2 SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID ELECTRON-SPIN-RESONANCE; SI-29 HYPERFINE-STRUCTURE; HIGH-PURITY SILICA; E' CENTERS; VITREOUS-SILICA; CRYSTALLINE QUARTZ; SI/SIO2 INTERFACE; OXYGEN VACANCY; FUSED-SILICA; GLASSY SIO2 AB In this paper we review and examine paramagnetic point defects in thin film amorphous silicon dioxide (a-SiO2), which is an important insulating material in modern electronic devices. Findings unique to thin films are compared with results from bulk materials to yield a picture of the structural, physical, chemical, and electronic nature of the defect centers. The most important defect in a-SiO2 is emphasized, the trivalent silicon moiety termed the E' center. We examine the types of E' centers observed in radiation or injection damaged thermal oxides, ion sputtered oxides, plasma enhanced chemical vapor deposited oxides, ion implanted thermal oxides, plastically densified silica, fused silicas, and high surface area sol-gel oxides. The nature of the precursor moieties, and their electrical charging phenomena are discussed. The different varieties of E' centers are categorized, and the reliability of their distinct existence and classification is assessed. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RHEIN WESTFAL TH AACHEN,INST SEMICOND ELECTR,W-5100 AACHEN,GERMANY. UNIV MUNSTER,INST PHYS CHEM,W-4400 MUNSTER,GERMANY. RP WARREN, WL (reprint author), SANDIA NATL LABS,DIV ELECTR CERAM,ALBUQUERQUE,NM 87185, USA. NR 81 TC 99 Z9 99 U1 0 U2 12 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD MAR PY 1992 VL 139 IS 3 BP 872 EP 880 DI 10.1149/1.2069318 PG 9 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA HH077 UT WOS:A1992HH07700043 ER PT J AU WARREN, WL KANICKI, J RONG, FC POINDEXTER, EH AF WARREN, WL KANICKI, J RONG, FC POINDEXTER, EH TI PARAMAGNETIC POINT-DEFECTS IN AMORPHOUS-SILICON DIOXIDE AND AMORPHOUS-SILICON NITRIDE THIN-FILMS .2. A-SINX-H SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID DANGLING-BOND CENTERS; SI-29 HYPERFINE-STRUCTURE; PLASMA-DEPOSITED FILMS; LESS-THAN 1.2; ELECTRONIC-PROPERTIES; CORRELATION-ENERGY; CRYSTALLINE SIO2; 1ST OBSERVATION; MEMORY TRAPS; E' CENTER AB In this paper we review paramagnetic point defects in amorphous silicon nitride thin films. We will discuss two intrinsic paramagnetic defects: a trivalent silicon center, named the K-center, and the recently observed nitrogen dangling-bond center. We examine the structural identification, and the electronic properties of the K-center, as well as consider why a-SiNx:H is generally a very effective charge trapping dielectric. In addition, this paper compares and contrasts special features of the structure and electronic role of the paramagnetic point defects in both silicon dioxide and silicon nitride thin films; this may provide insight for further studies on the physics and chemistry of these dangling-bond centers in both materials. C1 IBM CORP,THOMAS J WATSON RES CTR,DIV RES,YORKTOWN HTS,NY 10598. USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP WARREN, WL (reprint author), SANDIA NATL LABS,DIV ELECTR CERAM,ALBUQUERQUE,NM 87185, USA. NR 70 TC 79 Z9 79 U1 0 U2 6 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD MAR PY 1992 VL 139 IS 3 BP 880 EP 889 DI 10.1149/1.2069319 PG 10 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA HH077 UT WOS:A1992HH07700044 ER PT J AU IKEUCHI, H SAKANO, T SANCHEZ, J MASON, AD PRUITT, BA AF IKEUCHI, H SAKANO, T SANCHEZ, J MASON, AD PRUITT, BA TI THE EFFECTS OF PLATELET-ACTIVATING-FACTOR (PAF) AND A PAF ANTAGONIST (CV-3988) ON SMOKE-INHALATION INJURY IN AN OVINE MODEL SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 51ST ANNUAL SESSION OF THE AMERICAN ASSOC FOR THE SURGERY OF TRAUMA CY SEP 11-14, 1991 CL PHILADELPHIA, PA SP AMER ASSOC SURG TRAUMA ID IGE-ANAPHYLAXIS; RABBIT; SHOCK; NEUTROPHIL; RELEASE; SHEEP AB The role of platelet-activating factor (PAF) in inhalation injury was studies in sheep, using CV-3988, a PAF antagonist. Following smoke exposure, 15 sheep were divided into three groups of five. Group I animals were untreated; group II animals were treated with CV-3988 before and after exposure; group III animals were treated only after exposure. In group I, platelet and WBC counts were markedly changed within 6 hours (p < 0.05); in the treated groups, alteration of cell counts was not obvious. Blood malondialdehyde (MDA) levels were increased significantly only in group I. Blood PGE2 and TXB2 levels did not differ among the groups. Mean tissue MDA and mean bronchoalveolar lavage fluid (BALF) MDA concentrations were significantly increased in group I (p < 0.01); mean BALF TXB2 levels were significantly decreased in group I (p < 0.01). These data suggest that PAF affects inhalation injury through modulation of lipid oxygenation and that PAF antagonists may offer therapeutic benefit in the management of this injury. C1 OSAKA PREFECTURE HOSP,DEPT EMERGENCY MED,OSAKA,JAPAN. RP IKEUCHI, H (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 27 TC 12 Z9 14 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAR PY 1992 VL 32 IS 3 BP 344 EP 350 DI 10.1097/00005373-199203000-00012 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA HM904 UT WOS:A1992HM90400012 PM 1548723 ER PT J AU MAGGIO, MI COSTABILE, RA FOLEY, JP AF MAGGIO, MI COSTABILE, RA FOLEY, JP TI ENDOSCOPICALLY CONTROLLED PLACEMENT OF URETHROVESICAL ANASTOMOTIC SUTURES AFTER RADICAL RETROPUBIC PROSTATECTOMY SO JOURNAL OF UROLOGY LA English DT Article DE PROSTATECTOMY; ANASTOMOSIS, SURGICAL AB Radical retropubic prostatectomy is a challenging surgical procedure. One of the technically demanding aspects of this surgery is the urethrovesical anastomosis. We have used a 21F cystoscope in selected patients to enhance the quality of our urethrally placed anastomotic sutures. This technique may be a beneficial adjunct in those cases in which delineation of the transected urethral margin is difficult to identify secondary to urethral retraction and should be considered an addition to the presently available armamentarium of maneuvers used to make the urethrovesical anastomosis technically easier and more precise. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP MAGGIO, MI (reprint author), WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307, USA. NR 12 TC 8 Z9 9 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAR PY 1992 VL 147 IS 3 BP 903 EP 904 PN 2 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA HF976 UT WOS:A1992HF97600031 PM 1538493 ER PT J AU HUGHES, SA AF HUGHES, SA TI ESTIMATING WAVE-INDUCED BOTTOM VELOCITIES AT VERTICAL WALL SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article AB A linear theory equation is presented for estimating water velocity parameters beneath reflected, two-dimensional, irregular, nonbreaking waves as a function of the incident wave spectrum, water depth, and spatial location. The estimation procedure requires specification of wave reflection and phase shift as a function of frequency. For the special case of normally incident, unidirectional, nonbreaking irregular waves being perfectly reflected by a vertical wall, the equation provides estimates of near-bottom (above boundary layer) fluid particle velocity parameters as a function of only the incident wave spectrum, water depth, and distance from the wall. Comparisons between laboratory fluid velocity measurements and velocity estimates based on the measured incident spectrum are good for this special case. Furthermore, the distribution of peak horizontal velocities compares well with estimates based on the Rayleigh distribution. For two cases of a TMA spectrum wherein the significant height and peak period vary but other shape parameters are held constant, explicit formulas are given to estimate maximum bottom velocity parameters as a function of water depth, peak period, and significant height. RP HUGHES, SA (reprint author), USA,COSTAL ENGN RES CTR,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 8 TC 12 Z9 12 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD MAR-APR PY 1992 VL 118 IS 2 BP 175 EP 192 DI 10.1061/(ASCE)0733-950X(1992)118:2(175) PG 18 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA HE648 UT WOS:A1992HE64800004 ER PT J AU MYHRE, SW AF MYHRE, SW TI DEFENSE WITNESS IMMUNITY AND THE DUE-PROCESS STANDARD - A PROPOSED AMENDMENT TO THE MANUAL FOR COURT-MARTIAL SO MILITARY LAW REVIEW LA English DT Article C1 USA,JUDGE ADVOCATE GEN SCH,WASHINGTON,DC 20310. RP MYHRE, SW (reprint author), US MARINE CORPS,WASHINGTON,DC, USA. NR 29 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1992 VL 136 BP 69 EP 114 PG 46 WC Law SC Government & Law GA JB219 UT WOS:A1992JB21900003 ER PT J AU ADDICOTT, JF AF ADDICOTT, JF TI OPERATION DESERT STORM - LEE,R.E. OR SHERMAN,W.T. SO MILITARY LAW REVIEW LA English DT Article RP ADDICOTT, JF (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV INT LAW,WASHINGTON,DC 20310, USA. NR 45 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1992 VL 136 BP 115 EP 135 PG 21 WC Law SC Government & Law GA JB219 UT WOS:A1992JB21900004 ER PT J AU BORCH, FL AF BORCH, FL TI A RAPE OF JUSTICE - MACARTHUR AND THE NEW-GUINEA HANGINGS - LUSZKI,WA SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1992 VL 136 BP 161 EP 165 PG 5 WC Law SC Government & Law GA JB219 UT WOS:A1992JB21900006 ER PT J AU BORCH, FL AF BORCH, FL TI A FIGHTER PILOTS LIFE - GABRESKI,F, MOLESWORTH,C SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1992 VL 136 BP 165 EP 171 PG 7 WC Law SC Government & Law GA JB219 UT WOS:A1992JB21900007 ER PT J AU BORCH, FL AF BORCH, FL TI THE MARCH OF CONQUEST - TAYLOR,T SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1992 VL 136 BP 171 EP 175 PG 5 WC Law SC Government & Law GA JB219 UT WOS:A1992JB21900010 ER PT J AU URECH, EM AF URECH, EM TI VETERANS BENEFITS MANUAL - AN ADVOCATES GUIDE TO REPRESENTING VETERANS AND THEIR DEPENDENTS - WILDHABER,ME, ABRAMS,RB, STICHMAN,BF, ADDELSTONE,DF SO MILITARY LAW REVIEW LA English DT Book Review RP URECH, EM (reprint author), USA,JUDGE ADVOCATE GEN SCH,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1992 VL 136 BP 175 EP 177 PG 3 WC Law SC Government & Law GA JB219 UT WOS:A1992JB21900012 ER PT J AU BORCH, FL AF BORCH, FL TI FRONT AND CENTER - BINDER,LJ SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1992 VL 136 BP 177 EP 180 PG 4 WC Law SC Government & Law GA JB219 UT WOS:A1992JB21900013 ER PT J AU BORCH, FL AF BORCH, FL TI DRUG AND ALCOHOL TESTING - ADVISING THE EMPLOYER - TURKULA,WD SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1992 VL 136 BP 180 EP 181 PG 2 WC Law SC Government & Law GA JB219 UT WOS:A1992JB21900014 ER PT J AU BLOK, RJ AF BLOK, RJ TI SIMULATOR SICKNESS IN THE UNITED-STATES-ARMY UH-60A BLACKHAWK FLIGHT SIMULATOR SO MILITARY MEDICINE LA English DT Article AB Realistic training in aviation now includes the use of sophisticated flight simulators which can provide near total perception of aircraft flight, Reports of simulator sickness seem to be increasing in simulators with multi-directional motion, computer-generated imagery, and infinity optics. A voluntary, subjective, symptom-oriented questionnaire was completed by 141 pilots after training in the UH-60A 2B38 Blackhawk flight simulator. Thirty-six percent reported positive symptoms of motion sickness. Pilots may be at risk if they fly too soon after simulator training and a mandatory grounding time is advised. RP BLOK, RJ (reprint author), 25TH AVIAT BRIGADE,DIV INFANTRY LIGHT 25,SCHOFIELD BARRACKS,HI 96785, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1992 VL 157 IS 3 BP 109 EP 111 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA HG831 UT WOS:A1992HG83100007 PM 1603398 ER PT J AU GRIMES, SR WHIDDON, RG HOLLSTEN, D TREVINO, SB NAUSCHUETZ, WF AF GRIMES, SR WHIDDON, RG HOLLSTEN, D TREVINO, SB NAUSCHUETZ, WF TI EFFECT OF POVIDONE-IODINE IRRIGATION ON THE PREOPERATIVE CHEMICAL PREPARATION OF THE EYE SO MILITARY MEDICINE LA English DT Article AB Preoperative eyes which had been treated with gentamicin for one-half day were subjected to one of two povidone-iodine (PI) preparations. The control eye was prepared using a previously described 5% PI one-drop technique, while the paired eye was irrigated with a 0.02 % PI solution. Aerobic and anaerobic bacterial cultures were taken of each eye before and after PI applications. Statistical analysis of the data indicates that both techniques were equally effective in reducing surface colonization of the anaerobic cocci and bacilli, the viridans streptococci and micrococci. Both methods were also equally ineffective in reducing the numbers of coagulase-negative staphylococci from the surface of the eye. With the apparent emergence of gentamicin-resistant coagulase-negative staphylococci, the potential for staphylococcal endophthalmitis is increasing. RP GRIMES, SR (reprint author), BROOKE ARMY MED CTR,DEPT OPHTHALMOL,MICROBIOL SECT,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 6 Z9 10 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1992 VL 157 IS 3 BP 111 EP 113 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA HG831 UT WOS:A1992HG83100008 PM 1603399 ER PT J AU MCPHEE, SD TOWNSEND, LJ AF MCPHEE, SD TOWNSEND, LJ TI A STUDY OF ORGANIZATIONAL COMMITMENT AND JOB-SATISFACTION AMONG AIR-FORCE OCCUPATIONAL-THERAPY OFFICERS SO MILITARY MEDICINE LA English DT Article AB The purpose of this study is to describe the levels of organizational commitment and job satisfaction found in Air Force occupational therapy officers assigned to the Biomedical Sciences Corps. A questionnaire was mailed to 27 eligible active duty Air Force occupational therapy officers. Of the 23 surveys returned, 22 were usable, an 82% response rate. The occupational therapy officer's demographic characteristics are detailed for all officers and then by company and field grade respondents. Results indicate that these officers have moderately high levels of organizational commitment and job satisfaction. Analyses of the results suggest that field grade officers express more organizational commitment than company grade officers. Both company grade and field grade officers display the same level of job satisfaction. Upon closer scrutiny, though, company grade officers are found to be more satisfied with promotions and rewards gained from their jobs. Field grade officers express higher levels of satisfaction with pay, supervision, and relationship with coworkers. RP MCPHEE, SD (reprint author), USA,ACAD HLTH SCI,OCCUPAT THERAPY BRANCH,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1992 VL 157 IS 3 BP 117 EP 121 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA HG831 UT WOS:A1992HG83100010 PM 1603401 ER PT J AU KLOTZ, FW ORLANDI, PA REUTER, G COHEN, SJ HAYNES, JD SCHAUER, R HOWARD, RJ PALESE, P MILLER, LH AF KLOTZ, FW ORLANDI, PA REUTER, G COHEN, SJ HAYNES, JD SCHAUER, R HOWARD, RJ PALESE, P MILLER, LH TI BINDING OF PLASMODIUM-FALCIPARUM 175-KILODALTON ERYTHROCYTE BINDING ANTIGEN AND INVASION OF MURINE ERYTHROCYTES REQUIRES N-ACETYLNEURAMINIC ACID BUT NOT ITS O-ACETYLATED FORM SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY LA English DT Article DE PLASMODIUM-FALCIPARUM; RED CELL; MEROZOITE; RECEPTOR; SIALIC ACID ID MOUSE ERYTHROCYTES; MALARIAL PARASITES; MEROZOITE INVASION; INFLUENZA-VIRUS; C-VIRUSES; RECEPTOR; PROTEINS; SURFACE; IDENTIFICATION; GLYCOPROTEIN AB Sialic acid on human erythrocytes is involved in invasion by the human malaria parasite, Plasmodium falciparum. Mouse erythrocytes were used as a reagent to explore the question of whether erythrocyte sialic acid functions as a nonspecific negative charge or whether the sialic acid is a necessary structural part of the receptor for merozoites. Human erythrocytes contain N-acetylneuraminic acid (Neu5Ac), whereas mouse erythrocytes, which are also invaded by P. falciparum merozoites, contain 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac2) and N-glycoloylneuraminic acid (Neu5Gc), in addition to Neu5Ac. We compared the effects of sialidase and influenza C virus esterase treatments of mouse erythrocytes on invasion and the binding of a 175-kDa P. falciparum protein (EBA- 1 75), a sialic acid-dependent malaria ligand implicated in the invasion process. Sialidase-treated mouse erythrocytes were refractory to invasion by P. falciparum merozoites and failed to bind EBA-175. Influenza C virus esterase, which converts Neu5,9Ac2 to Neu5Ac, increased both invasion efficiency and EBA-175 binding to mouse erythrocytes. Thus, the parasite and EBA-175 discriminate between Neu5Ac and Neu5,9Ac2, that is, the C-9 acetyl group interferes with EBA-175 binding and invasion by P. falciparum merozoites. This indicates that sialic acid is part of a receptor for invasion. C1 NIAID,PARASIT DIS LAB,BLDG 4,ROOM 126,BETHESDA,MD 20892. DNAX RES INST MOLEC & CELLULAR BIOL INC,RES INST,PALO ALTO,CA. CUNY MT SINAI SCH MED,DEPT MICROBIOL,NEW YORK,NY 10029. UNIV KIEL,INST BIOCHEM,W-2300 KIEL 1,GERMANY. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. OI Palese, Peter/0000-0002-0337-5823 NR 30 TC 60 Z9 61 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-6851 J9 MOL BIOCHEM PARASIT JI Mol. Biochem. Parasitol. PD MAR PY 1992 VL 51 IS 1 BP 49 EP 54 DI 10.1016/0166-6851(92)90199-T PG 6 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA HG814 UT WOS:A1992HG81400006 PM 1565137 ER PT J AU SIM, BKL TOYOSHIMA, T HAYNES, JD AIKAWA, M AF SIM, BKL TOYOSHIMA, T HAYNES, JD AIKAWA, M TI LOCALIZATION OF THE 175-KILODALTON ERYTHROCYTE BINDING ANTIGEN IN MICRONEMES OF PLASMODIUM-FALCIPARUM MEROZOITES SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY LA English DT Note DE ERYTHROCYTE BINDING ANTIGEN; PLASMODIUM-FALCIPARUM; MEROZOITE; MICRONEME ID KNOWLESI; INVASION C1 JOHNS HOPKINS UNIV,BALTIMORE,MD 21218. CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106. RP SIM, BKL (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. FU NIAID NIH HHS [AI-10645] NR 15 TC 91 Z9 92 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-6851 J9 MOL BIOCHEM PARASIT JI Mol. Biochem. Parasitol. PD MAR PY 1992 VL 51 IS 1 BP 157 EP 160 PG 4 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA HG814 UT WOS:A1992HG81400018 PM 1565131 ER PT J AU BERNING, PR NIILER, A AF BERNING, PR NIILER, A TI METHODS OF ADAPTING ION-BEAM ANALYSIS TECHNIQUES FOR USE ON CURVED SURFACES SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article ID SILICON AB Information concerning surface contamination of powder particles obtained by ion beam analysis would prove very useful in the fields of powder metallurgy and ceramics, however current methods of analysis generally require flat, laterally uniform sample surfaces. We describe two methods for adapting backscattering spectroscopy techniques for use on samples consisting of small spherical or cylindrical particles. These methods make use of current flat surface spectra simulation programs and require no additional programming. The first method simulates a spherical or cylindrical surface with an array of tilted flat segments and constructs an energy spectrum by summing flat surface spectra simulations from each segment. The second method utilizes flat surface depth profiles that, when used in a flat surface simulation program, will mimic the results for a particular spherical or cylindrical surface configuration. The limitations, and relative strengths and weakness, of each method will be discussed. Examples of the use of these methods in conjunction with Rutherford Backscattering Spectroscopy will be shown, although they are also applicable to other types of ion beam analysis. RP BERNING, PR (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD MAR PY 1992 VL 63 IS 4 BP 434 EP 444 DI 10.1016/0168-583X(92)95216-E PG 11 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA HN168 UT WOS:A1992HN16800010 ER PT J AU WALTON, TL AF WALTON, TL TI INTERIM GUIDANCE FOR PREDICTION OF WAVE RUN-UP ON BEACHES SO OCEAN ENGINEERING LA English DT Article AB A method of predicting wind wave run-up (for any desired quantile or statistic value) on smooth linear mild slopes has been presented. The method is based on a re-analysis of an extensive laboratory measurement run-up data base of Mase [(1989), Random wave run-up height on gentle slopes. J. WatWay, Port, Coastal, Ocean Engng Div., ASCE 115, 649-661] and Mase and Iwagaki [(1984), Run-up of random waves on gentle slopes. Proceedings of the 19th Coastal Engineering Conference, ASCE, pp. 593-609]. The predictive run-up measurement equation is based on a modified dimensionless form of the Hunt [(1959), Design of seawalls and breakwaters. Proc. J. WatWay Harbour Div., ASCE, 85, 123-152] formula with a linear intercept term (which appears to be due to mild slope wave set-up). Values of the slope coefficient in the run-up predictive equation are based on the Rayleigh probability distribution in accordance with findings from the present re-analysis of the Mase data set. Run-up prediction for a given quantile or statistic value is then found utilizing the slope coefficient based on Rayleigh theory combined with the predictive linear equation found herein for the average run-up height R(mean) in a stationary wave train. In the case of rough slopes and permeable beaches, it is obvious that the true run-up would be reduced from the predicted values of run-up given by the smooth slope method provided herein. At present the extent of such reduction is a matter of speculation. As an interim measure, it is recommended that conservative design practice be followed by using the run-up values predicted via the method given herein unless sufficient justification for run-up reduction based on laboratory or field findings can be provided. RP WALTON, TL (reprint author), USA,CORPS ENGINEERS,COASTAL ENGN RES CTR,VICKSBURG,MS 39180, USA. NR 9 TC 2 Z9 2 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD MAR PY 1992 VL 19 IS 2 BP 199 EP 207 DI 10.1016/0029-8018(92)90015-V PG 9 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA HE814 UT WOS:A1992HE81400006 ER PT J AU THOMPSON, SH CHARLES, GA CRAIG, DB AF THOMPSON, SH CHARLES, GA CRAIG, DB TI CORRELATION OF ORAL-DISEASE WITH THE REED,WALTER STAGING SCHEME FOR HIV-1-SEROPOSITIVE PATIENTS SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS LA English DT Article ID HIV INFECTION; AIDS; CLASSIFICATION; DIAGNOSIS; RISK AB This study correlates the prevalent oral disease findings in 390 patients seropositive for human immunodeficiency virus type 1 (HIV-1) with their level of staging (Walter Reed) and depletion of peripheral helper T lymphocytes (CD4+). Chronic lymphadenopathy of the head and neck was a common finding (59.2%) that occurred early in staging progression and did not correlate with depression of helper T-cell levels. Of the three prevalent oral disease findings (oral hairy leukoplakia (OHL), candidiasis, necrotizing ulcerative gingivitis [NUG]) only OHL and NUG were significantly correlated with helper T-cell depletion. The occurrence of visually detectable OHL and NUG corresponds to depletion of peripheral helper T-lymphocyte values in a range of 157 to 299 cells/mm3. This range may represent a more accurate value for biologically significant lymphocyte depletion than the Walter Reed value of 400 cells/mm3. The presence of OHL showed a weak statistical correlation with staging progression, indicating deteriorating immunoregulation. No cases of Kaposi's sarcoma or other HIV-1-associated oral diseases were observed in the sample population, regardless of the patient's staging category or peripheral helper T-lymphocyte count. C1 DWIGHT D EISENHOWER ARMY MED CTR,OTORHINOLARYNGOL HEAD & NECK SURG SERV,FT GORDON,GA 30905. DWIGHT D EISENHOWER ARMY MED CTR,DEPT MED,FT GORDON,GA 30905. RP THOMPSON, SH (reprint author), TRIPLER ARMY MED CTR,DENTAC,ORAL PATHOL SERV,HONOLULU,HI 96859, USA. NR 12 TC 27 Z9 30 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD MAR PY 1992 VL 73 IS 3 BP 289 EP 292 DI 10.1016/0030-4220(92)90123-8 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HJ297 UT WOS:A1992HJ29700009 PM 1532056 ER PT J AU YOUNG, TD AF YOUNG, TD TI THE NEED FOR NATO-EUROPE SUBSTRATEGIC NUCLEAR-WEAPONS SO ORBIS-A JOURNAL OF WORLD AFFAIRS LA English DT Article RP YOUNG, TD (reprint author), USA,COLL WAR,INST STRATEG STUDIES,CARLISLE,PA, USA. NR 30 TC 0 Z9 0 U1 0 U2 0 PU JAI PRESS INC PI GREENWICH PA 55 OLD POST RD-#2, PO BOX 1678, GREENWICH, CT 06836-1678 SN 0030-4387 J9 ORBIS-J WORLD AFF JI Orbis-J. World Aff. PD SPR PY 1992 VL 36 IS 2 BP 227 EP 238 PG 12 WC International Relations SC International Relations GA HG341 UT WOS:A1992HG34100006 ER PT J AU ZEIGLER, D LYNCH, SA MUIR, J BENJAMIN, J MAX, MB AF ZEIGLER, D LYNCH, SA MUIR, J BENJAMIN, J MAX, MB TI TRANSDERMAL CLONIDINE VERSUS PLACEBO IN PAINFUL DIABETIC NEUROPATHY SO PAIN LA English DT Article DE CONTROLLED CLINICAL TRIALS; ADRENERGIC AGONISTS; ANALGESIA; PAIN; NOREPINEPHRINE ID RELIEVES POSTHERPETIC NEURALGIA; EPIDURAL CLONIDINE; CANCER PAIN; ANALGESIA; AMITRIPTYLINE; HYPERALGESIA AB In a randomized, double-blind, 2-period crossover study, 24 patients with pain due to diabetic polyneuropathy received transdermal clonidine, 0.3 mg/day, and placebo patches, each for 6 weeks. Pain was assessed daily by a 13-word descriptor list. Mean daily pain scores for the 6th week, the primary outcome variable, averaged 13% lower with clonidine than with placebo (95% conf. lim. for clonidine effect: 29% reduction to 3% increase in pain), which was not statistically significant (P = 0.11, 2-tailed paired t test). After this study, however, 9 patients who wished to continue clonidine had single (3 patients) or multiple (6 patients) cycles of clonidine withdrawal and rechallenge. Seven of 9 patients consistently reported return of pain with patch withdrawal followed by relief upon retreatment. One patient had an equivocal response, and the other patient had no relief upon retreatment. The 7 responders appeared similar to the other 17 patients in pain quality and neurological exam. We conclude that there may be a subset of patients with diabetic polyneuropathy who respond to transdermal clonidine. Further research is needed to identify features of neuropathic pain that predict drug response and to develop study designs that are more sensitive to a response in a subset of patients. C1 NIDR, NEUROBIOL & ANESTHESIOL BRANCH,PAIN RES CLIN, BLDG 10,ROOM 3C-405, BETHESDA, MD 20892 USA. NIH, DEPT CLIN CTR NURSING, BETHESDA, MD 20892 USA. WALTER REED ARMY MED CTR, DEPT PHYS MED & REHABIL, WASHINGTON, DC 20307 USA. NR 31 TC 53 Z9 54 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 EI 1872-6623 J9 PAIN JI Pain PD MAR PY 1992 VL 48 IS 3 BP 403 EP 408 DI 10.1016/0304-3959(92)90092-P PG 6 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA HM571 UT WOS:A1992HM57100017 PM 1594263 ER PT J AU ANDERSON, LL PALLER, AS MALPASS, D SCHMIDT, ML BERGER, TG AF ANDERSON, LL PALLER, AS MALPASS, D SCHMIDT, ML BERGER, TG TI CHEDIAK-HIGASHI-SYNDROME IN A BLACK-CHILD SO PEDIATRIC DERMATOLOGY LA English DT Article AB Chediak-Higashi syndrome (CHS) is an uncommon genetic disorder with a constellation of clinical, pathologic, and immunologic manifestations. It is rarely reported in blacks. Pathognomonic intracellular inclusions in white blood cells are well recognized; however, characteristic abnormal melanin aggregation into giant melanosomes also occurs, as can be readily seen by histologic evaluation of hair. We present a case of CHS in a black child. C1 BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,FT SAM HOUSTON,TX 78234. NR 0 TC 5 Z9 5 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 SN 0736-8046 J9 PEDIATR DERMATOL JI Pediatr. Dermatol. PD MAR PY 1992 VL 9 IS 1 BP 31 EP 36 DI 10.1111/j.1525-1470.1992.tb00322.x PG 6 WC Dermatology; Pediatrics SC Dermatology; Pediatrics GA HJ831 UT WOS:A1992HJ83100006 PM 1574473 ER PT J AU LEEK, MR HANNA, TE MARSHALL, L AF LEEK, MR HANNA, TE MARSHALL, L TI ESTIMATION OF PSYCHOMETRIC FUNCTIONS FROM ADAPTIVE TRACKING PROCEDURES SO PERCEPTION & PSYCHOPHYSICS LA English DT Article ID STATISTICAL PROPERTIES; PSYCHOPHYSICAL PROCEDURES; PSYCHOACOUSTICS; THRESHOLD AB Because adaptive tracking procedures are designed to avoid stimulus levels far from a target threshold value, the psychometric function constructed from the trial-by-trial data in the track may be accurate near the target level but a poor reflection of performance at levels far removed from the target. A series of computer simulations was undertaken to assess the reliability and accuracy of psychometric functions generated from data collected in up-down adaptive tracking procedures. Estimates of psychometric function slopes were obtained from trial-by-trial data in simulated adaptive tracks and compared with the true characteristics of the functions used to generate the tracks. Simulations were carried out for three psychophysical procedures and two target performance levels, with tracks generated by psychometric functions with three different slopes. The functions reconstructed from the tracking data were, for the most part, accurate reflections of the true generating functions when at least 200 trials were included in the tracks. However, for 50- and 100-trial tracks, slope estimates were biased high for all simulated experimental conditions. Correction factors for slope estimates from these tracks are presented. There was no difference in the accuracy and reliability of slope estimation due to target level for the adaptive track, and only minor differences due to psychophysical procedure. It is recommended that, if both threshold and slope of psychometric functions are to be estimated from the trial-by-trial tracking data, at least 100 trials should be included in the tracks, and a three- or four-alternative forced-choice procedure should be used. However, good estimates can also be obtained using the two-alternative forced-choice procedure or less than 100 trials if appropriate corrections for bias are applied. C1 USN,SUBMARINE MED RES LAB,SUBMARINE BASE NEW LONDON,GROTON,CT 06340. RP LEEK, MR (reprint author), WALTER REED ARMY MED CTR,CTR AUDIOL & SPEECH,WASHINGTON,DC 20307, USA. NR 20 TC 53 Z9 53 U1 0 U2 2 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0031-5117 J9 PERCEPT PSYCHOPHYS JI Percept. Psychophys. PD MAR PY 1992 VL 51 IS 3 BP 247 EP 256 DI 10.3758/BF03212251 PG 10 WC Psychology; Psychology, Experimental SC Psychology GA HH655 UT WOS:A1992HH65500005 PM 1561050 ER PT J AU DOWLING, JP AF DOWLING, JP TI COULOMB SCATTERING NEAR MIRRORS - QUANTUM CORRECTIONS TO THE RUTHERFORD FORMULA SO PHYSICAL REVIEW A LA English DT Article ID 2ND QUANTIZATION; ELECTRODYNAMICS AB When Coulomb scattering takes place near mirrors, additional scattering amplitudes occur due to the reflection of virtual photons. Under certain conditions these amplitudes can interfere, in a purely quantum-mechanical fashion, giving rise to possibly observable fringes in the differential-scattering cross section. The effect is calculated here for a Coulomb potential near a single mirror and also between a pair of parallel mirrors. The experimental feasibility is then briefly discussed. RP DOWLING, JP (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAP SCI DIRECTORATE,AMSMI-RD-WS,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 11 TC 1 Z9 1 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD MAR 1 PY 1992 VL 45 IS 5 BP 3121 EP 3125 DI 10.1103/PhysRevA.45.3121 PG 5 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA HH617 UT WOS:A1992HH61700061 ER PT J AU POSTAN, A RAI, J BOWDEN, CM AF POSTAN, A RAI, J BOWDEN, CM TI STIMULATED BRILLOUIN-SCATTERING IN A 2-LEVEL SYSTEM SO PHYSICAL REVIEW A LA English DT Article ID PHASE CONJUGATION; 4-WAVE; SODIUM; RESONANCES; FLUIDS; BEAMS; VAPOR; GAIN AB Resonances in the interaction of a saturable two-level system with stimulated Brillouin scattering are discussed. These resonances appear due to the coupling between the two-level system and the resonant acoustic waves that are excited in the host substance by a coherent electromagnetic field of two mutually detuned, counterpropagating laser beams. Results for sodium vapor mixed with nitrogen buffer gas are presented. C1 INDIAN INST TECHNOL,DEPT PHYS,KANPUR 208016,UTTAR PRADESH,INDIA. USA,MISSILE COMMAND,WEAP SCI DIRECTORATE,CTR RES DEV & ENGN,REDSTONE ARSENAL,AL 35898. RP POSTAN, A (reprint author), TECHNION ISRAEL INST TECHNOL,DEPT PHYS,IL-32000 HAIFA,ISRAEL. NR 36 TC 3 Z9 3 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD MAR 1 PY 1992 VL 45 IS 5 BP 3294 EP 3299 DI 10.1103/PhysRevA.45.3294 PG 6 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA HH617 UT WOS:A1992HH61700081 ER PT J AU AKYEL, Y BELT, M AF AKYEL, Y BELT, M TI A MICROWAVE-TRANSPARENT OPERANT CHAMBER FOR RATS SO PHYSIOLOGY & BEHAVIOR LA English DT Note DE MICROWAVE FIELDS; OPERANT CHAMBER; SCHEDULES OF REINFORCEMENT AB To study the operant behavior of rats in a microwave field, an operant chamber equipped with a response lever, stimulus lights, and a feeder was constructed using polycarbonate and fiber optic material. The chamber was connected to a personal computer located outside of the microwave chamber to program the schedules of reinforcement and to collect data. The operant chamber did not interfere with the microwave field and kept the subject's body parallel to the E-field for maximum absorption. C1 WALTER REED ARMY MED CTR,MICROWAVE RES,WASHINGTON,DC 20307. RP AKYEL, Y (reprint author), ERC BIOSERV CORP,SUITE 222,6 MONTGOMERY VILLAGE AVE,GAITHERSBURG,MD 20879, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD MAR PY 1992 VL 51 IS 3 BP 647 EP 650 DI 10.1016/0031-9384(92)90191-4 PG 4 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA HN239 UT WOS:A1992HN23900029 PM 1523241 ER PT J AU BURLESON, DG JOHNSON, A SALIN, M MASON, AD PRUITT, BA AF BURLESON, DG JOHNSON, A SALIN, M MASON, AD PRUITT, BA TI IDENTIFICATION OF NEOPTERIN AS A POTENTIAL INDICATOR OF INFECTION IN BURNED PATIENTS SO PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE LA English DT Article ID LIQUID-CHROMATOGRAPHY; SERUM; MARKER AB Several fluorescent substances are present in the supernatants of acid-precipitated whole blood or plasma from burned patients. Perchloric acid supernatants of sera from infected, but not uninfected, burned rats contained a fluorescent substance with maximum emission at 420 nm at 355-nm excitation (355 ex/420 em). In this study of serum from burned human patients, several fluorescent substances were resolved by reverse-phase high-pressure liquid chromatography. One of these fluorescent components had an high-pressure liquid chromatography retention time and fluorescent characteristics identical to those of neopterin. The identification of this component as neopterin was verified by thermospray mass spectrometry. Serum neopterin concentrations were then determined in supernatants of patient serum samples having various levels of 355 ex/420 em fluorescence. A correlation was found between the concentrations of neopterin determined by high-pressure liquid chromatography and the presence of bacteremia in burned patients. These findings suggest that neopterin, which is a useful indicator of infection in other clinical settings, may also be an indicator of infection in burned patients. C1 USA, INST SURG RES, BIOCHEM BRANCH, FT SAM HOUSTON, TX 78234 USA. NR 22 TC 12 Z9 12 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0037-9727 J9 P SOC EXP BIOL MED JI Proc. Soc. Exp. Biol. Med. PD MAR PY 1992 VL 199 IS 3 BP 305 EP 310 PG 6 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HE842 UT WOS:A1992HE84200007 PM 1539033 ER PT J AU LESTER, LS FANSELOW, MS AF LESTER, LS FANSELOW, MS TI NOCTURNALITY AS A DEFENSIVE BEHAVIOR IN THE RAT - AN ANALYSIS IN TERMS OF SELECTIVE ASSOCIATION BETWEEN LIGHT AND AVERSIVE-STIMULATION SO PSYCHOLOGICAL RECORD LA English DT Article ID CS MODALITY; CONDITIONED SUPPRESSION; SHOCK-INTENSITY; FEAR; NALOXONE; COMPONENTS; ANALGESIA; PATTERNS; RHYTHMS; SYSTEM AB One striking aspect of the rat's daily activity pattern is its strong nocturnal tendency. The present research tests the assumption that nocturnality in the rat serves a defensive function. If nocturnality represents a form of defense, the rat may associate light with aversive events more readily than it associates dark with aversive events. Experiment 1 examined this hypothesis in terms of the rat's foraging behavior while living in an operant chamber. Electric footshock delivered to the grid floor near the response lever simulated the influence of predation during feeding. The results indicated that foraging behavior in the rat is sensitive to the risk of predation. Rats that had shock paired with either the light or dark phase reorganized their meal taking and reduced time spent at risk. However, the finding that the largest changes in foraging occurred when shock was delivered exclusively during the dark phase did not support the hypothesis that nocturnal feeding is a defensive behavior and was not indicative of a selective association between light and aversive events. Similar conclusions were reached when the defensive behavior freezing was used as the discriminative response in differential conditioning studies. Rate of differentiation was faster when shock was paired with a dark phase CS, relative to pairings with a light phase CS (Experiment 4). Rats failed to show differential freezing in a light S+ chamber and a dark S- chamber (Experiment 2), but did so with S+ and S- conditions reversed. Similar results with a light or dark chamber paired with a food US (Experiment 3) suggested two things: first, rats that acquired the discrimination when light phase signaled shock may have relied on endogenous cues rather than light/dark per se; second, the results obtained with pairings of darkness and shock were not indicative of a selective association between darkness and aversive events. C1 UNIV CALIF LOS ANGELES,LOS ANGELES,CA 90024. RP LESTER, LS (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 66 TC 5 Z9 5 U1 0 U2 1 PU PSYCHOLOGICAL RECORD PI GAMBIER PA KENYON COLLEGE, GAMBIER, OH 43022 SN 0033-2933 J9 PSYCHOL REC JI Psychol. Rec. PD SPR PY 1992 VL 42 IS 2 BP 221 EP 253 PG 33 WC Psychology, Multidisciplinary SC Psychology GA HP244 UT WOS:A1992HP24400006 ER PT J AU FITZGERALD, DT AF FITZGERALD, DT TI TO CALIFORNIA BY SEA - A MARITIME HISTORY OF THE CALIFORNIA GOLD-RUSH - DELGADO,JP SO PUBLIC HISTORIAN LA English DT Book Review RP FITZGERALD, DT (reprint author), USA CORPS ENGINEERS,HONOLULU,HI, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SPR PY 1992 VL 14 IS 2 BP 95 EP 96 PG 2 WC History SC History GA HR113 UT WOS:A1992HR11300016 ER PT J AU LEFEVER, EB ROSENTHAL, RM RAMAMURTHY, S AF LEFEVER, EB ROSENTHAL, RM RAMAMURTHY, S TI INTRAPULMONARY PLACEMENT OF A PLEURAL CATHETER SO REGIONAL ANESTHESIA LA English DT Article DE ANESTHETICS, LOCAL; ANESTHETIC TECHNIQUES, REGIONAL, PLEURAL, INTERCOSTAL; COMPLICATIONS, PNEUMOTHORAX; PAIN, POSTHERPETIC NEURALGIA AB Objective and Conclusion. A case of intrapulmonary placement of a pleural catheter is described that was likely due to the presence of focal pleural thickening at the site of catheter insertion. RP LEFEVER, EB (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 SN 0146-521X J9 REGION ANESTH JI Reg. Anesth. PD MAR-APR PY 1992 VL 17 IS 2 BP 107 EP 109 PG 3 WC Anesthesiology SC Anesthesiology GA HQ438 UT WOS:A1992HQ43800010 PM 1581248 ER PT J AU BAUMGARTEN, RK AF BAUMGARTEN, RK TI INTRAPLEURAL, INTERPLEURAL, OR PLEURAL BLOCK - SIMPLER MAY BE BETTER SO REGIONAL ANESTHESIA LA English DT Letter RP BAUMGARTEN, RK (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 SN 0146-521X J9 REGION ANESTH JI Reg. Anesth. PD MAR-APR PY 1992 VL 17 IS 2 BP 116 EP 116 PG 1 WC Anesthesiology SC Anesthesiology GA HQ438 UT WOS:A1992HQ43800018 PM 1581255 ER PT J AU JOHNSON, AR QUIGLEY, CJ AF JOHNSON, AR QUIGLEY, CJ TI A VISCOHYPERELASTIC MAXWELL MODEL FOR RUBBER VISCOELASTICITY SO RUBBER CHEMISTRY AND TECHNOLOGY LA English DT Article; Proceedings Paper CT MEETING OF THE RUBBER DIVISION OF THE AMERICAN CHEMICAL SOC CY MAY 21-24, 1991 CL TORONTO, CANADA SP AMER CHEM SOC, RUBBER DIV AB A new viscoelastic model for rubber is presented. It is similar to a Maxwell internal solid model in which all the solids are hyperelastic. A key feature of this model is its ability to accurately predict step-strain relaxation test data for very large strains. A method to obtain the constitutive models for the solids is presented for the three legged version and is used with existing data in the literature to compute variable-rate uniaxial pull tests. The finite-element implementation of this theory is given. Computations are made for a uniaxial constant-strain-rate test using a nearly incompressible axisymmetric version of the finite-element method. RP JOHNSON, AR (reprint author), USA,MAT TECHNOL LAB,MECH & STRUCT BRANCH,SLCMT MRS,WATERTOWN,MA 02172, USA. NR 25 TC 30 Z9 40 U1 1 U2 3 PU AMER CHEMICAL SOC INC PI AKRON PA RUBBER DIV UNIV AKRON PO BOX 499, AKRON, OH 44309-0499 SN 0035-9475 J9 RUBBER CHEM TECHNOL JI Rubber Chem. Technol. PD MAR-APR PY 1992 VL 65 IS 1 BP 137 EP 153 DI 10.5254/1.3538596 PG 17 WC Polymer Science SC Polymer Science GA HQ111 UT WOS:A1992HQ11100010 ER PT J AU MEDALIA, AI ALESI, AL MEAD, JL AF MEDALIA, AI ALESI, AL MEAD, JL TI PATTERN ABRASION AND OTHER MECHANISMS OF WEAR OF TANK TRACK PADS SO RUBBER CHEMISTRY AND TECHNOLOGY LA English DT Article ID RUBBER ABRASION C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP MEDALIA, AI (reprint author), MEDALIA ASSOCIATES INC,30 DORR RD,NEWTON,MA 02158, USA. NR 41 TC 23 Z9 27 U1 0 U2 7 PU AMER CHEMICAL SOC INC PI AKRON PA RUBBER DIV UNIV AKRON PO BOX 499, AKRON, OH 44309-0499 SN 0035-9475 J9 RUBBER CHEM TECHNOL JI Rubber Chem. Technol. PD MAR-APR PY 1992 VL 65 IS 1 BP 154 EP 175 DI 10.5254/1.3538597 PG 22 WC Polymer Science SC Polymer Science GA HQ111 UT WOS:A1992HQ11100011 ER PT J AU BUDE, J HESS, K IAFRATE, GJ AF BUDE, J HESS, K IAFRATE, GJ TI IMPACT IONIZATION - BEYOND THE GOLDEN-RULE SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 7TH INTERNATIONAL CONF ON HOT CARRIERS IN SEMICONDUCTORS ( HCIS-7 ) CY JUL 01-05, 1991 CL NARA, JAPAN SP NARA PREFECTURE, NARA CITY, NARA CONVENT BUR, WATANABE MEM FDN ADV SCI & TECHNOL AB The influence of collision broadening due to phonons and the intracollisional field effect on the inverse Auger process have been examined. Results are presented for silicon and show for the first time the wave-vector dependence of the ionization rate including collision broadening. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP BUDE, J (reprint author), UNIV ILLINOIS,BECKMAN INST ADV SCI & TECHNOL & ECE,URBANA,IL 61801, USA. NR 9 TC 6 Z9 6 U1 2 U2 3 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAR PY 1992 VL 7 IS 3B BP B506 EP B508 DI 10.1088/0268-1242/7/3B/132 PG 3 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA HL262 UT WOS:A1992HL26200134 ER PT J AU CHOI, KK DUTTA, M NEWMAN, PG IAFRATE, GJ AF CHOI, KK DUTTA, M NEWMAN, PG IAFRATE, GJ TI EXCITATION HOT-ELECTRON SPECTROSCOPY OF QUANTUM-WELL STRUCTURES SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 7TH INTERNATIONAL CONF ON HOT CARRIERS IN SEMICONDUCTORS ( HCIS-7 ) CY JUL 01-05, 1991 CL NARA, JAPAN SP NARA PREFECTURE, NARA CITY, NARA CONVENT BUR, WATANABE MEM FDN ADV SCI & TECHNOL AB By using hot-electron transistor structures, we showed that the hot-electrons in the base suffer little or no energy loss within a distance less than 1500 angstrom. We utilize this hot-electron property to construct a highly sensitive 10-mu-m infrared hot-electron transistor. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP CHOI, KK (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 7 TC 0 Z9 0 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAR PY 1992 VL 7 IS 3B BP B251 EP B252 DI 10.1088/0268-1242/7/3B/060 PG 2 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA HL262 UT WOS:A1992HL26200062 ER PT J AU DASSARMA, S CAMPOS, VB STROSCIO, MA KIM, KW AF DASSARMA, S CAMPOS, VB STROSCIO, MA KIM, KW TI CONFINED PHONON MODES AND HOT-ELECTRON ENERGY RELAXATION IN SEMICONDUCTOR MICROSTRUCTURES SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article ID GAAS QUANTUM WELLS; RESOLVED RAMAN-SCATTERING; WAVELENGTH OPTICAL PHONONS; LO PHONONS; INTERSUBBAND RELAXATION; DOUBLE HETEROSTRUCTURES; ALAS SUPERLATTICES; EXCITATIONS; WIRE; POLARIZABILITY AB The role of confined phonon modes in determining the energy relaxation of hot electrons in low-dimensional semiconductor microstructures is discussed within a dielectric continuum model for the LO phonon confinement and a long wavelength Frohlich model for the electron-phonon interaction. Numerical results are provided for the hot-electron relaxation rate as a function of electron temperature and density for GaAs quantum wells and quantum wires by taking into account emission of slab phonon modes. Comparison with existing experimental results shows some evidence for slab phonon emission in intersubband electronic relaxation in reasonably narrow quantum wells. It is argued that most experiments can be interpreted in terms of an electron-bulk phonon interaction model (i.e. by taking into account the effect of confinement only on the electrons and assuming the phonons to be the usual bulk three-dimensional phonons) because a number of important physical processes, such as screening, the hot phonon effect, phonon self-energy correction etc, make it difficult to distinguish quantitatively between various models for phonon confinement, except perhaps in the narrowest (< 50 angstrom) wells and wires. Detailed numerical results for the calculated intra-subband relaxation rate in GaAs quantum wires are provided within the slab phonon and the electron temperature model, including the effects of dynamical screening, quantum degeneracy and non-equilibrium hot phonons. C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. N CAROLINA STATE UNIV, DEPT ELECT & COMP ENGN, RALEIGH, NC 27695 USA. RP UNIV MARYLAND, DEPT PHYS, JOINT PROGRAM ADV ELECTR MAT, COLLEGE PK, MD 20742 USA. RI Das Sarma, Sankar/B-2400-2009 OI Das Sarma, Sankar/0000-0002-0439-986X NR 56 TC 18 Z9 18 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0268-1242 EI 1361-6641 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAR PY 1992 VL 7 IS 3B BP B60 EP B66 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA HL262 UT WOS:A1992HL26200017 ER PT J AU GRUBIN, HL GOVINDAN, TR MORRISON, BJ STROSCIO, MA AF GRUBIN, HL GOVINDAN, TR MORRISON, BJ STROSCIO, MA TI DENSITY-MATRIX AND QUANTUM-MOMENT STUDIES OF SINGLE-BARRIER AND MULTIPLE-BARRIER STRUCTURES SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 7TH INTERNATIONAL CONF ON HOT CARRIERS IN SEMICONDUCTORS ( HCIS-7 ) CY JUL 01-05, 1991 CL NARA, JAPAN SP NARA PREFECTURE, NARA CITY, NARA CONVENT BUR, WATANABE MEM FDN ADV SCI & TECHNOL AB The time-dependent Liouville equation for the density matrix in the coordinate representation, incorporating scattering effects through a quasi-Fermi level, and Poisson's equation have been solved numerically for a single- and double-barrier structure using algorithms based on 'characteristics', and show significant charge accumulation on the emitter side of the barrier, as well as significant charge screening in multiple-barrier structures. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP GRUBIN, HL (reprint author), SCI RES ASSOCIATES INC,GLASTONBURY,CT 06033, USA. NR 5 TC 3 Z9 3 U1 2 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAR PY 1992 VL 7 IS 3B BP B434 EP B438 DI 10.1088/0268-1242/7/3B/112 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA HL262 UT WOS:A1992HL26200114 ER PT J AU GRUBIN, HL GOVINDAN, TR MORRISON, BJ FERRY, DK STROSCIO, MA AF GRUBIN, HL GOVINDAN, TR MORRISON, BJ FERRY, DK STROSCIO, MA TI TEMPERATURE DESCRIPTION OF TRANSPORT IN SINGLE-BARRIER AND MULTIPLE-BARRIER STRUCTURES SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 7TH INTERNATIONAL CONF ON HOT CARRIERS IN SEMICONDUCTORS ( HCIS-7 ) CY JUL 01-05, 1991 CL NARA, JAPAN SP NARA PREFECTURE, NARA CITY, NARA CONVENT BUR, WATANABE MEM FDN ADV SCI & TECHNOL ID QUANTUM AB Barrier calculations based upon solutions of the Liouville equation in the coordinate representation reveal a complicated spatial dependence of the quantum distribution function near and within the barriers. Within the framework of classical transport this spatial dependence suggests equilibrium electron temperature values that differ from the ambient. The prospect of quantum heating and cooling under equilibrium conditions is examined and dispelled in favour of an interpretation that includes density-gradient contributions. C1 ARIZONA STATE UNIV,TEMPE,AZ 85287. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP GRUBIN, HL (reprint author), SCI RES ASSOCIATES INC,GLASTONBURY,CT 06033, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAR PY 1992 VL 7 IS 3B BP B360 EP B363 DI 10.1088/0268-1242/7/3B/093 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA HL262 UT WOS:A1992HL26200095 ER PT J AU KIM, KW LITTLEJOHN, MA STROSCIO, MA IAFRATE, GJ AF KIM, KW LITTLEJOHN, MA STROSCIO, MA IAFRATE, GJ TI TRANSITION FROM LO-PHONON TO SO-PHONON SCATTERING IN MESOSCALE STRUCTURES SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 7TH INTERNATIONAL CONF ON HOT CARRIERS IN SEMICONDUCTORS ( HCIS-7 ) CY JUL 01-05, 1991 CL NARA, JAPAN SP NARA PREFECTURE, NARA CITY, NARA CONVENT BUR, WATANABE MEM FDN ADV SCI & TECHNOL ID RECTANGULAR QUANTUM WIRE; ELECTRONIC POLARIZABILITY; DOUBLE HETEROSTRUCTURES; FROHLICH INTERACTION; SUPERLATTICES; MODES AB Macroscopic dielectric continuum models of optical-phonon modes predict enhancements in the magnitudes of the surface-optical (SO) modes in double-barrier heterostructures as the heterojunction-to-heterojunction separation is reduced. In this paper, the ratio of electron scattering by the SO-phonon modes to that by the (electrostatic) confined longitudinal-optical- (LO-) phonon modes is calculated for a GaAs/AlAs short-period superlattice based on the assumption that electron-SO-phonon scattering may be described by a scalar potential. The scaling of the ratio of electron-SO-phonon scattering to electron-LO-phonon scattering as a function of the superlattice period provides a sensitive test of the appropriateness of the scalar-potential model. The effect of phonon confinement on electron-optical-phonon scattering rates is presented for rectangular quantum wires as well. A major conclusion of these new results is that it is essential to model phonon confinement properly in predicting carrier transport properties in mesoscale structures. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP KIM, KW (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 23 TC 3 Z9 3 U1 0 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAR PY 1992 VL 7 IS 3B BP B49 EP B51 DI 10.1088/0268-1242/7/3B/013 PG 3 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA HL262 UT WOS:A1992HL26200015 ER PT J AU MICKEVICIUS, R MITIN, VV KIM, KW STROSCIO, MA AF MICKEVICIUS, R MITIN, VV KIM, KW STROSCIO, MA TI ELECTRON HIGH-FIELD TRANSPORT IN MULTISUBBAND QUANTUM WIRE STRUCTURES SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 7TH INTERNATIONAL CONF ON HOT CARRIERS IN SEMICONDUCTORS ( HCIS-7 ) CY JUL 01-05, 1991 CL NARA, JAPAN SP NARA PREFECTURE, NARA CITY, NARA CONVENT BUR, WATANABE MEM FDN ADV SCI & TECHNOL ID PHONONS AB The Monte Carlo simulation of electron transport in multisubband quasi-one-dimensional GaAs/AlAs quantum wires (QWIS) are presented. The electron intrasubband and intersubband scattering by surface-optical and confined longitudinal-optical phonons in QWIS has been included in the program. It is demonstrated that at room temperature the electron drift velocity in the QWI is suppressed by electron intersubband scattering and does not exceed the bulk material values. The energy dependence of the total scattering rate in ideal QWIS exhibits multiple sharp peaks related to intersubband transitions. The scattering rates in the real QWIS with variable thicknesses are calculated as well. The results show that even small variation in thickness leads to a significant broadening of the very first peaks and complete washing-out of the peak-like structure at higher energies. C1 N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP MICKEVICIUS, R (reprint author), WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48202, USA. NR 12 TC 10 Z9 10 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAR PY 1992 VL 7 IS 3B BP B299 EP B301 DI 10.1088/0268-1242/7/3B/074 PG 3 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA HL262 UT WOS:A1992HL26200076 ER PT J AU MCMAHON, JR FRANKE, R AF MCMAHON, JR FRANKE, R TI KNOT SELECTION FOR LEAST-SQUARES THIN PLATE SPLINES SO SIAM JOURNAL ON SCIENTIFIC AND STATISTICAL COMPUTING LA English DT Article DE KNOT SELECTION; LEAST SQUARES; THIN PLATE SPLINES; DIRICHLET TESSELLATION; SCATTERED DATA ID SCATTERED DATA; APPROXIMATION; INTERPOLATION AB An algorithm for the selection of knot point locations for approximation of functions from large sets of scattered data by least squares thin plate splines is given. The algorithm is based on the idea that each data point is equally important in defining the surface, which allows the knot selection process to be decoupled from the least squares. Properties of the algorithm are investigated, and examples demonstrating it are given. Results of some least squares approximations are given and compared with other approximation methods. C1 USN,POSTGRAD SCH,MONTEREY,CA 93943. RP MCMAHON, JR (reprint author), US MIL ACAD,DEPT MATH,W POINT,NY 10996, USA. NR 14 TC 10 Z9 12 U1 0 U2 0 PU SIAM PUBLICATIONS PI PHILADELPHIA PA 3600 UNIV CITY SCIENCE CENTER, PHILADELPHIA, PA 19104-2688 SN 0196-5204 J9 SIAM J SCI STAT COMP PD MAR PY 1992 VL 13 IS 2 BP 484 EP 498 DI 10.1137/0913026 PG 15 WC Mathematics, Applied SC Mathematics GA HE400 UT WOS:A1992HE40000003 ER PT J AU HARTLE, AE AF HARTLE, AE TI FACING EVIL - KEKES,J SO SOCIETY LA English DT Book Review RP HARTLE, AE (reprint author), US MIL ACAD,PHILOSOPHY PROGRAM,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0147-2011 J9 SOCIETY JI Society PD MAR-APR PY 1992 VL 29 IS 3 BP 91 EP 94 PG 4 WC Social Sciences, Interdisciplinary; Sociology SC Social Sciences - Other Topics; Sociology GA HF942 UT WOS:A1992HF94200015 ER PT J AU MARION, GM SCHLESINGER, WH FONTEYN, PJ AF MARION, GM SCHLESINGER, WH FONTEYN, PJ TI ALKALINITY MEASUREMENTS IN WATER EXTRACTS OF CALCAREOUS SOILS SO SOIL SCIENCE SOCIETY OF AMERICA JOURNAL LA English DT Note ID ION ACTIVITY PRODUCTS; CALCIUM-CARBONATE; SUPERSATURATION AB In soil carbonate solubility studies, it is usually assumed that total alkalinity is equal to inorganic-C alkalinity. Recent studies have raised questions about the validity of this assumption. This study reexamined previously published soil data from grass-oak (Quercus spp.) woodlands and deserts to test the hypothesis that total alkalinity is equal to inorganic-C alkalinity. Total alkalinity was measured with strong-acid titration, while inorganic-C alkalinity was calculated from pH and the partial pressure of CO2 (pCO2) measurements. Within the limits of error, calculated inorganic C alkalinity (Y) was equal to measured total alkalinity (X) (Y = 0.01 + 0.998X, r2 = 0.97). A recommendation was made for overdetermining the state of experimental systems in solubility studies; this allows one to check the internal consistency of experimental measurements, equilibrium constants, and model assumptions. C1 SAN FRANCISCO STATE UNIV,OFF RES & PROFESS DEV,SAN FRANCISCO,CA 94132. DUKE UNIV,DEPT BOT,DURHAM,NC 27706. RP MARION, GM (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 18 TC 1 Z9 1 U1 0 U2 5 PU SOIL SCI SOC AMER PI MADISON PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 SN 0361-5995 J9 SOIL SCI SOC AM J JI Soil Sci. Soc. Am. J. PD MAR-APR PY 1992 VL 56 IS 2 BP 598 EP 600 PG 3 WC Soil Science SC Agriculture GA HR731 UT WOS:A1992HR73100042 ER PT J AU MORRIS, JT MCALLISTER, CK AF MORRIS, JT MCALLISTER, CK TI BUBONIC PLAGUE SO SOUTHERN MEDICAL JOURNAL LA English DT Note RP MORRIS, JT (reprint author), BROOKE ARMY MED CTR,DEPT MED,INTERNAL MED SERV,FT SAM HOUSTON,TX 78234, USA. NR 8 TC 2 Z9 2 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD MAR PY 1992 VL 85 IS 3 BP 326 EP 327 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA HK616 UT WOS:A1992HK61600019 PM 1546359 ER PT J AU STORELLA, RJ SCHOUCHOFF, AL FUJII, M HILL, J FLETCHER, JE JIANG, MS SMITH, LA AF STORELLA, RJ SCHOUCHOFF, AL FUJII, M HILL, J FLETCHER, JE JIANG, MS SMITH, LA TI PRELIMINARY EVIDENCE FOR A POSTSYNAPTIC ACTION OF BETA-BUNGAROTOXIN IN MAMMALIAN SKELETAL-MUSCLE SO TOXICON LA English DT Note ID CROTOXIN; VENOM AB Two hours after treatment with beta-bungarotoxin (0.34-0.4-mu-M), when there was complete neuromuscular block, the peak contracture response to 50-mu-M succinylcholine was significantly reduced by about 35% in the mouse phrenic nerve-diaphragm preparation. Additionally, significant phospholipase A2 activity was detected on primary cell cultures from skeletal muscle which were incubated for 2 hr with concentrations of beta-bungarotoxin greater-than-or-equal-to 0.1-mu-M. Thus, beta-bungarotoxin appears to have pharmacologically and biochemically detectable postsynaptic actions in mammalian muscle systems. C1 USA,MED RES INST INFECT DIS,DEPT TOXINOL,DIV PATHOL,FT DETRICK,MD 21702. RP STORELLA, RJ (reprint author), HAHNEMANN UNIV,DEPT ANESTHESIOL,PHILADELPHIA,PA 19102, USA. NR 18 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD MAR PY 1992 VL 30 IS 3 BP 349 EP 354 DI 10.1016/0041-0101(92)90876-7 PG 6 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA HR719 UT WOS:A1992HR71900013 PM 1529466 ER PT J AU ODUOLA, AMJ SOWUNMI, A MILHOUS, WK KYLE, DE MARTIN, RK WALKER, O SALAKO, LA AF ODUOLA, AMJ SOWUNMI, A MILHOUS, WK KYLE, DE MARTIN, RK WALKER, O SALAKO, LA TI INNATE RESISTANCE TO NEW ANTIMALARIAL-DRUGS IN PLASMODIUM-FALCIPARUM FROM NIGERIA SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MEFLOQUINE; INVITRO; CHLOROQUINE; MALARIA; AMPLIFICATION; AFRICA; GENE AB The rapid dissemination of chloroquine-resistant Plasmodium falciparum in West Africa has been well documented and represents a significant health threat to autochthonous populations. The methodical development of alternative chemotherapeutic agents demands that dispensing new antimalarial drugs (mefloquine, halofantrine, and artemisinin [qinghaosu]) be closely monitored in order to protect their clinical utility. Indeed, mefloquine-resistant strains of P. falciparum have been reported. We present data from experiments in vitro on the innate resistance of P. falciparum isolates to mefloquine as well as a disturbing observation of transient resistance to artemisinin. The implications for the extended efficacy of these new antimalarial drugs are addressed. C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. UNIV IBADAN,COLL MED,DEPT PHARMACOL & THERAPEUT,IBADAN,NIGERIA. NR 21 TC 37 Z9 37 U1 0 U2 0 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD MAR-APR PY 1992 VL 86 IS 2 BP 123 EP 126 DI 10.1016/0035-9203(92)90533-I PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA HV022 UT WOS:A1992HV02200004 PM 1440764 ER PT J AU BROWN, AE HERRINGTON, DA WEBSTER, HK CLYDE, DF SZTEIN, MB DAVIS, JR BEIER, MS EDELMAN, R AF BROWN, AE HERRINGTON, DA WEBSTER, HK CLYDE, DF SZTEIN, MB DAVIS, JR BEIER, MS EDELMAN, R TI URINARY NEOPTERIN IN VOLUNTEERS EXPERIMENTALLY INFECTED WITH PLASMODIUM-FALCIPARUM SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MALARIA PARASITES; INTERFERON-GAMMA AB To investigate the kinetics of monocyte/macrophage activation in falciparum malaria we determined urinary neopterin values serially in experimentally infected volunteers. Three subjects who had been immunized with irradiated sporozoites via mosquito bites served as controls. These individuals remained aparasitaemic, afebrile and without a rise in neopterin after challenge by infective mosquitoes. Four non-immune subjects developed Plasmodium falciparum parasitaemia, fever (3 of 4) and sharp rises in neopterin. Parasite densities reached 10-100 parasitized erythrocytes per mu-l before elevations in temperature or neopterin levels were detected. Onset of fever preceded the rise in neopterin excretion by one day. Prompt chemotherapy was associated with the clearance of parasites from the blood and the return of temperature and neopterin levels to normal. C1 UNIV MARYLAND,CTR VACCINE DEV,BALTIMORE,MD 21201. RP BROWN, AE (reprint author), ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,315-6 RAJUITHI RD,BANGKOK 10400,THAILAND. FU NIAID NIH HHS [N01-AI-62553] NR 15 TC 7 Z9 7 U1 0 U2 2 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD MAR-APR PY 1992 VL 86 IS 2 BP 134 EP 136 DI 10.1016/0035-9203(92)90539-O PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA HV022 UT WOS:A1992HV02200009 PM 1440769 ER PT J AU LOGAN, TM DAVIES, FG LINTHICUM, KJ KSIAZEK, TG AF LOGAN, TM DAVIES, FG LINTHICUM, KJ KSIAZEK, TG TI RIFT-VALLEY FEVER ANTIBODY IN HUMAN SERA COLLECTED AFTER AN OUTBREAK IN DOMESTIC-ANIMALS IN KENYA SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Note ID VIRUS C1 VET RES LAB,KABETE,KENYA. RP LOGAN, TM (reprint author), USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21701, USA. NR 16 TC 11 Z9 11 U1 0 U2 0 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD MAR-APR PY 1992 VL 86 IS 2 BP 202 EP 203 DI 10.1016/0035-9203(92)90571-S PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA HV022 UT WOS:A1992HV02200030 PM 1440789 ER PT J AU IRVINE, KN EBERHARDT, AJ AF IRVINE, KN EBERHARDT, AJ TI MULTIPLICATIVE, SEASONAL ARIMA MODELS FOR LAKE ERIE AND LAKE-ONTARIO WATER LEVELS SO WATER RESOURCES BULLETIN LA English DT Article DE TIME SERIES ANALYSIS; WATER MANAGEMENT; WATER LEVELS; LAKE ERIE; LAKE ONTARIO; ARIMA MODELS AB Federal agencies in the U.S. and Canada continuously examine methods to improve understanding and forecasting of Great Lakes water level dynamics in an effort to reduce the negative impacts of fluctuating levels incurred by interests using the lakes. The short term, seasonal and long term water level dynamics of lakes Erie and Ontario are discussed. Multiplicative, seasonal ARIMA models are developed for lakes Erie and Ontario using standardized, monthly mean level data for the period 1900 to 1986. The most appropriate model identified for each lake had the general form: (1 0 1)(0 1 1)12. The data for each lake were subdivided by time periods (1900 to 1942; 1943 to 1986) and the model coefficients estimated for the subdivided data were similar, indicating general model stability for the entire period of record. The models estimated for the full data sets were used to forecast levels 1,2,3, and 6 months ahead for a period of high levels (1984 to 1986). The average absolute forecast error for Lake Erie was 0.049m, 0.076m, 0.091m and 0.128m for the 1, 2,3, and 6 month forecasts, respectively. The average absolute forecast error for Lake Ontario was 0.058m, 0.095m, 0.120m and 0.136m for the 1,2,3, and 6 month forecasts, respectively. The ARIMA models provide additional information on water level time series structure and dynamics. The models also could be coordinated with current forecasting methods, possibly improving forecasting accuracy. C1 SUNY COLL BUFFALO,CTR ENVIRONM RES & EDUC,BUFFALO,NY 14222. USA,CORPS ENGINEERS,WATER CONTROL SECT,BUFFALO DIST,BUFFALO,NY 14207. RP IRVINE, KN (reprint author), SUNY COLL BUFFALO,DEPT GEOG & PLANNING,1300 ELMWOOD AVE,BUFFALO,NY 14222, USA. NR 28 TC 21 Z9 21 U1 1 U2 3 PU AMER WATER RESOURCES ASSOC PI HERNDON PA 950 HERNDON PARKWAY SUITE 300, HERNDON, VA 20170-5531 SN 0043-1370 J9 WATER RESOUR BULL JI Water Resour. Bull. PD MAR-APR PY 1992 VL 28 IS 2 BP 385 EP 396 PG 12 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA JF797 UT WOS:A1992JF79700014 ER PT J AU BAKERFULCO, CJ BUCHBINDER, JC TORRI, SA ASKEW, EW AF BAKERFULCO, CJ BUCHBINDER, JC TORRI, SA ASKEW, EW TI DIETARY STATUS OF MARINE CORPS OFFICER CANDIDATES SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1682 EP A1682 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27100480 ER PT J AU BECKER, WK SHIPPEE, R MASON, AD PRUITT, BA AF BECKER, WK SHIPPEE, R MASON, AD PRUITT, BA TI DIETARY UREA CYCLE AMINO-ACIDS ALTER PLASMA AMINO-ACID LEVELS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,SAN ANTONIO,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1966 EP A1966 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27102127 ER PT J AU CHANG, FCT BENTON, BJ AF CHANG, FCT BENTON, BJ TI THE INFLUENCE OF BEHAVIORS AND STATES OF AROUSAL ON BULBAR RESPIRATORY-RELATED DISCHARGE PATTERNS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1828 EP A1828 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27101325 ER PT J AU CHANG, SKW GONZALEZ, RR AF CHANG, SKW GONZALEZ, RR TI HUMAN-BODY CONVECTIVE HEAT-TRANSFER DETERMINATION EMPLOYING NAPHTHALENE DISKS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A2015 EP A2015 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27102404 ER PT J AU CHUANG, AH MCPHERSON, JC MCPHERSON, JC AF CHUANG, AH MCPHERSON, JC MCPHERSON, JC TI HEMOLYTIC EFFECT OF SODIUM-FLUORIDE SO FASEB JOURNAL LA English DT Meeting Abstract C1 EISENHOWER ARMY MED CTR,FT GORDON,GA. MED COLL GEORGIA,AUGUSTA,GA 30912. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1764 EP A1764 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27100953 ER PT J AU DURKOT, MJ HOYT, RW DARRIGRAND, A KAMIMORI, G HUBBARD, L CYMERMAN, A AF DURKOT, MJ HOYT, RW DARRIGRAND, A KAMIMORI, G HUBBARD, L CYMERMAN, A TI CHRONIC HYPOBARIC HYPOXIA (427-TORR) DECREASES INTRACELLULAR AND TOTAL-BODY WATER IN IMMATURE MICROSWINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1774 EP A1774 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27101009 ER PT J AU ELSAYED, NM NAKASHIMA, JM POSTLETHWAIT, EM AF ELSAYED, NM NAKASHIMA, JM POSTLETHWAIT, EM TI CHANGES IN URIC-ACID LEVELS AFTER VENTILATING ISOLATED PERFUSED RAT LUNGS WITH DIFFERENT O2 TENSIONS SO FASEB JOURNAL LA English DT Meeting Abstract C1 LETTERMAN ARMY INST RES,SAN FRANCISCO,CA 94129. UNIV TEXAS,MED BRANCH,GALVESTON,TX 77550. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV CALIF LOS ANGELES,SCH PUBL HLTH,LOS ANGELES,CA 90024. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1817 EP A1817 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27101261 ER PT J AU FULCO, CS TRAD, LA FORTE, VA GONZALEZ, J IWANYK, EJ HOYT, RW CYMERMAN, A AF FULCO, CS TRAD, LA FORTE, VA GONZALEZ, J IWANYK, EJ HOYT, RW CYMERMAN, A TI USE OF HYPOXIC AND CARBON-DIOXIDE SENSITIVITY TESTS TO PREDICT THE INCIDENCE AND SEVERITY OF ACUTE MOUNTAIN-SICKNESS (AMS) AT MODERATE ALTITUDES (3800M) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1773 EP A1773 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27101004 ER PT J AU GORDON, RK DUERRE, JA CHIANG, PK AF GORDON, RK DUERRE, JA CHIANG, PK TI ASYMMETRIC LOCATION AND UNIQUE CHARACTERISTICS OF MEMBRANE PHOSPHOLIPID METHYLTRANSFERASE (PLM) IN HL-60 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV N DAKOTA,SCH MED,GRAND FORKS,ND 58202. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1833 EP A1833 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27101355 ER PT J AU GUO, ZM QIAN, C LIU, CT PETERS, CJ AF GUO, ZM QIAN, C LIU, CT PETERS, CJ TI CHANGES IN CATECHOLAMINE AND SEROTONIN CONCENTRATIONS IN CEREBROSPINAL-FLUID, BRAIN, AND PLASMA OF GUINEA-PIGS INFECTED WITH PICHINDE VIRUS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INF DIS,FREDERICK,MD 21702. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A2030 EP A2030 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27102496 ER PT J AU HAZLEWOOD, CF PETERS, CJ LIU, CT AF HAZLEWOOD, CF PETERS, CJ LIU, CT TI SPECTRAL CHANGES OF THE LUNG-TISSUE OF PICHINDE VIRUS-INFECTED GUINEA-PIG BY HIGH-RESOLUTION NUCLEAR-MAGNETIC-RESONANCE (NMR) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INFECT DIS RES INST,FREDERICK,MD 21702. BAYLOR COLL MED,HOUSTON,TX 77030. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1669 EP A1669 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27100406 ER PT J AU IWANYK, EJ SMITH, S BEIDLEMAN, BA KOBRICK, JL ROBERTS, A CYMERMAN, A AF IWANYK, EJ SMITH, S BEIDLEMAN, BA KOBRICK, JL ROBERTS, A CYMERMAN, A TI EFFECT OF PROLONGED HIGH-ALTITUDE EXPOSURE ON INTRAOCULAR-PRESSURE, VISUAL-FIELDS, ACUITY, VERGENCE, PHORIA AND VISUAL EVOKED-RESPONSE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. UNIV CALIF BERKELEY,BERKELEY,CA 94720. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1773 EP A1773 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27101003 ER PT J AU KIANG, JG AF KIANG, JG TI HYPERTHERMIA INCREASES INOSITOL 1,4,5-TRISPHOSPHATE IN HUMAN EPIDERMOID A-431-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1924 EP A1924 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27101879 ER PT J AU LINDSAY, DR ATKINS, JL AF LINDSAY, DR ATKINS, JL TI OXYGEN-TENSION IS NOT UNIFORM ON THE CORTICAL SURFACE OF THE NORMAL RAT-KIDNEY SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MARYLAND,SCH MED,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RI Atkins, James/B-3577-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1813 EP A1813 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27101237 ER PT J AU MEIER, HL CLAYSON, ET KELLY, SA CORUN, CM AF MEIER, HL CLAYSON, ET KELLY, SA CORUN, CM TI THE CONCENTRATION-DEPENDENT AND TIME-DEPENDENT SULFUR MUSTARD (HD) INITIATED DECREASE IN ATP LEVELS IN HUMAN LYMPHOCYTE PREPARATIONS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1619 EP A1619 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27100111 ER PT J AU PEARCE, FJ HART, C BROCKMAN, K WIESMANN, W AF PEARCE, FJ HART, C BROCKMAN, K WIESMANN, W TI EFFECT OF BRIEF, SUCCESSIVE PORTAL VENOUS (PV) OCCLUSIONS ON ARTERIAL AND PORTAL VENOUS ENDOTOXIN CONCENTRATIONS (ET) IN THE RAT SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A2040 EP A2040 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27102551 ER PT J AU RAO, M WASSEF, N ALVING, CR KRZYCH, U AF RAO, M WASSEF, N ALVING, CR KRZYCH, U TI A NOVEL ROUTE FOR PROCESSING OF LIPOSOME-ENCAPSULATED MALARIAL ANTIGEN SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A2003 EP A2003 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27102339 ER PT J AU WALLUM, TE HAZLEWOOD, CF LIU, CT AF WALLUM, TE HAZLEWOOD, CF LIU, CT TI DETECTION OF SPECTRAL CHANGES IN PLASMA AND RED-BLOOD-CELLS OF PICHINDE VIRUS-INFECTED GUINEA-PIGS - NUCLEAR-MAGNETIC-RESONANCE (NMR) TECHNOLOGIES SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1670 EP A1670 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27100407 ER PT J AU ZENG, GC DAVE, JR GAO, L BURBELO, PD RHODES, C BERNTON, E YAMADA, Y CHIANG, PK AF ZENG, GC DAVE, JR GAO, L BURBELO, PD RHODES, C BERNTON, E YAMADA, Y CHIANG, PK TI REQUIREMENT FOR THE C-FOS PROTOONCOGENE FOR THE INDUCTION OF 3T3-L1 FIBROBLASTS TO ADIPOCYTES BY INSULIN AND 3-DEAZAADENOSINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NIDR,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1992 VL 6 IS 5 BP A1936 EP A1936 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HH271 UT WOS:A1992HH27101951 ER PT J AU KIM, HJ RICHARDSON, M AF KIM, HJ RICHARDSON, M TI DETERMINATION OF 5-HYDROXYMETHYLFURFURAL BY ION-EXCLUSION CHROMATOGRAPHY WITH UV DETECTION SO JOURNAL OF CHROMATOGRAPHY LA English DT Note CT 15TH INTERNATIONAL SYMP ON COLUMN LIQUID CHROMATOGRAPHY ( HPLC 91 ) CY JUN 03-07, 1991 CL BASEL, SWITZERLAND SP SWISS ASSOC CHEMISTS ID ELECTROCHEMICAL DETECTION; SPECTROPHOTOMETRIC METHOD; HONEY; NITRITE; FOODS AB 5-Hydroxymethylfurfural (HMF) was determined without interferences in juices, honey, syrup, tomato paste, grape juice concentrate and dehydrated pear by anion-exclusion chromatographic separation and UV detection at 285 nm. The samples were mixed with water, filtered and injected without extensive sample treatment, which is normally required in conventional spectrophotometric or reversed-phase high-performance liquid chromatographic methods. HMF at the 50 ppb level was determined with a signal-to-noise ratio of 6. The recovery of HMF added to honey was 98% at the 10 ppm level and 91% at 30 ppm. RP KIM, HJ (reprint author), USA,CTR RES DEV & ENGN,FOOD ENGN DIRECTORATE,KANSAS ST,NATICK,MA 01760, USA. NR 21 TC 34 Z9 35 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR PD FEB 28 PY 1992 VL 593 IS 1-2 BP 153 EP 156 DI 10.1016/0021-9673(92)80280-8 PG 4 WC Chemistry, Analytical SC Chemistry GA HJ355 UT WOS:A1992HJ35500024 ER PT J AU ARMSTRONG, RD SQUIRE, DC MORETON, JE AF ARMSTRONG, RD SQUIRE, DC MORETON, JE TI EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON THE CONSECUTIVE ACQUISITION OF 4 LEVER RESPONSE CHAINS IN RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,CRDEC,ABERDEEN PROVING GROUND,MD 21010. UNIV MARYLAND,SCH PHARM,BALTIMORE,MD 21201. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A987 EP A987 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900297 ER PT J AU ASSAAD, A MITCHELTREE, L PETRALI, J BAZE, W HERNANDEZ, S DEWEY, H WOODARD, C WADE, J MOORE, D AF ASSAAD, A MITCHELTREE, L PETRALI, J BAZE, W HERNANDEZ, S DEWEY, H WOODARD, C WADE, J MOORE, D TI HEMATOLOGY, SERUM CHEMISTRY, AND PULMONARY PATHOLOGICAL ALTERATIONS IN SHEEP EXPOSED TO BIS(TRIFLUOROMETHYL)DISULFIDE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,EDGEWOOD,MD 21010. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1065 EP A1065 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900747 ER PT J AU BOYLE, T FINE, RL JETT, M AF BOYLE, T FINE, RL JETT, M TI ARACHIDONATE METABOLITES IN STAPHYLOCOCCAL ENTEROTOXIN-B (SEB)-STIMULATED RODENT SPLEEN-CELLS - INTERFERENCE IN 5-LIPOXYGENASE PATHWAY INHIBITS MITOGENESIS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV PATHOL,WASHINGTON,DC 20307. VET ADM MED CTR,DURHAM,NC 27705. GEORGETOWN UNIV,DEPT CHEM,WASHINGTON,DC 20057. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1564 EP A1564 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71903632 ER PT J AU BUCKPITT, A BRENNAN, P KIM, H CONE, N JOHNSON, D BAGGOT, JD CHUNG, H AF BUCKPITT, A BRENNAN, P KIM, H CONE, N JOHNSON, D BAGGOT, JD CHUNG, H TI DISPOSITION AND ELIMINATION OF THE ANTILESHMANIAL AGENT, WR-6026, IN RATS AFTER ORAL-DRUG ADMINISTRATION SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV CALIF DAVIS,DAVIS,CA 95616. WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1001 EP A1001 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900376 ER PT J AU BYERS, CE CAPACIO, BR AF BYERS, CE CAPACIO, BR TI THE DETERMINATION OF GRANISETRON IN GUINEA-PIG PLASMA BY HPLC SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1308 EP A1308 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71902150 ER PT J AU CARANTO, G WEIBEL, K LARRISON, R BRECHT, K ASHER, J SCHUTZ, M WOLFE, AD MAXWELL, DM DOCTOR, BP AF CARANTO, G WEIBEL, K LARRISON, R BRECHT, K ASHER, J SCHUTZ, M WOLFE, AD MAXWELL, DM DOCTOR, BP TI INVIVO AND INVITRO REACTIVATION OF SARIN INHIBITED FETAL BOVINE SERUM ACETYLCHOLINESTERASE BY HI-6 SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. USA,CHEM DEF RES INST,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1016 EP A1016 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900465 ER PT J AU CLAYBAUGH, JR FREUND, BJ LUTHER, G MULLER, K BENNETT, PB AF CLAYBAUGH, JR FREUND, BJ LUTHER, G MULLER, K BENNETT, PB TI EFFECTS OF HYPERBARIA (360 MSW) ON THE HORMONAL RESPONSE TO MAXIMAL EXERCISE IN MAN SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. USA,ENVIRONM MED RES INST,NATICK,MA 01760. DUKE UNIV,MED CTR,DURHAM,NC 27710. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1461 EP A1461 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71903040 ER PT J AU DUBOSE, DA MOREHOUSE, DH HINKLE, JR AF DUBOSE, DA MOREHOUSE, DH HINKLE, JR TI BOVINE AORTIC ENDOTHELIAL-CELL (BAEC) BARRIER FUNCTION FOLLOWING HYPERTHERMIC EXPOSURE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1035 EP A1035 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900575 ER PT J AU EDDINGTON, N KAMIMORI, GH LUGO, S HOYT, R DURKOT, M CYMERMAN, A AF EDDINGTON, N KAMIMORI, GH LUGO, S HOYT, R DURKOT, M CYMERMAN, A TI COMPARTMENTAL PHARMACOKINETIC (PK) MODEL TO CHARACTERIZE THE DISPOSITION OF CAFFEINE (CA) AT SEA-LEVEL (SL) AND AT HIGH-ALTITUDE (HA) AFTER SINGLE DOSE ADMINISTRATION TO MINIATURE SWINE (MS) SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MARYLAND,DEPT PHARMACEUT,BALTIMORE,MD 21201. WRAIR,DEPT BEHAV BIOL,WASHINGTON,DC 20307. USA,RIEM,DIV ALTITUDE,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A992 EP A992 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900327 ER PT J AU GRAY, RR GORDON, RK BUTLER, DL BROWN, ND CHIANG, PK AF GRAY, RR GORDON, RK BUTLER, DL BROWN, ND CHIANG, PK TI ANATOXIN-A EVOKED RELEASE OF ENDOGENOUS ACETYLCHOLINE FROM GUINEA-PIG ILEUM SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV BIOCHIM & GENET MICROBIENNE,WASHINGTON,DC 20307. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1014 EP A1014 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900451 ER PT J AU HOYT, RW FULCO, CS DURKOT, MJ STEIN, TP CYMERMAN, A AF HOYT, RW FULCO, CS DURKOT, MJ STEIN, TP CYMERMAN, A TI EFFECTS OF HIGH-ALTITUDE RESIDENCE ON LACTATE METABOLISM DURING EXERCISE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. UNIV MED & DENT NEW JERSEY,SCH OSTEOPATH MED,DEPT SURG,CAMDEN,NJ 08103. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1467 EP A1467 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71903073 ER PT J AU HUMMEL, RL GUO, ZM LIU, CT AF HUMMEL, RL GUO, ZM LIU, CT TI EFFECTS OF PICHINDE VIRAL-INFECTION ON PLASMA-CONCENTRATION OF ATRIAL-NATRIURETIC-PEPTIDE (ANP) IN GUINEA-PIGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 1 TC 2 Z9 2 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1491 EP A1491 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71903212 ER PT J AU JETT, M FINE, RL GEMSKI, P BOYLE, T HUNT, R CHATTERJEE, S MULSHINE, JL AF JETT, M FINE, RL GEMSKI, P BOYLE, T HUNT, R CHATTERJEE, S MULSHINE, JL TI LEUKOTRIENES VS 5-HETE - STAPHYLOCOCCAL ENTEROTOXIN-B (SEB) INDUCED 5-LIPOXYGENASE METABOLITES REFLECT TOXIC VS NONTOXIC RESPONSES SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV PATHOL,WASHINGTON,DC 20307. DUKE UNIV,MED CTR,DURHAM,NC 27710. JOHNS HOPKINS UNIV,DEPT PEDIAT,BALTIMORE,MD 21218. NIH,DCPC,BPRB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1053 EP A1053 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900678 ER PT J AU KAMIMORI, GH EDDINGTON, ND BRUNHART, AE MCCOY, SA AF KAMIMORI, GH EDDINGTON, ND BRUNHART, AE MCCOY, SA TI SATURATION KINETICS OF INDOCYANINE GREEN (ICG) FOLLOWING MULTIPLE DOSES IN HUMANS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,WASHINGTON,DC 20307. UNIV MARYLAND,DEPT PHARMACEUT,BALTIMORE,MD 21201. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1002 EP A1002 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900383 ER PT J AU KRAEMER, WJ DZIADOS, JE FLECK, SJ MARCHITELLI, L GORDON, SE MELLO, R FRYKMAN, PN HARMAN, E FRY, AC TRIPLETT, NT KOZIRIS, LP AF KRAEMER, WJ DZIADOS, JE FLECK, SJ MARCHITELLI, L GORDON, SE MELLO, R FRYKMAN, PN HARMAN, E FRY, AC TRIPLETT, NT KOZIRIS, LP TI HORMONAL RESPONSES TO HEAVY RESISTANCE EXERCISE IN WOMEN SO FASEB JOURNAL LA English DT Meeting Abstract C1 PENN STATE UNIV,CTR SPORTS MED,UNIV PK,PA 16802. USA,RIEM,DIV OCCUPAT PHYSIOL,NATICK,MA 01760. UNIV SO COLORADO,DIV SPORTS SCI,COLORADO SPRINGS,CO 80909. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1538 EP A1538 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71903482 ER PT J AU KRAMER, TR MOORE, RJ FRIEDL, KE MARTINEZLOPEZ, LE AF KRAMER, TR MOORE, RJ FRIEDL, KE MARTINEZLOPEZ, LE TI EFFECTS OF MULTIPLE STRESSORS DURING UNITED-STATES-ARMY RANGER TRAINING ON CELL-IMMUNE FUNCTIONS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USDA,HUMAN NUTR RES CTR,BELTSVILLE,MD 20705. USA,ENVIRONM MED RES INST,NATICK,MA 01760. MARTIN ARMY COMM HOSP,FT BENNING,GA 31905. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1214 EP A1214 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71901604 ER PT J AU LIU, CT GUO, ZM QIAN, C PETERS, CJ AF LIU, CT GUO, ZM QIAN, C PETERS, CJ TI INCREASED CONCENTRATION OF PLATELET-ACTIVATING-FACTOR IN GUINEA-PIG BRAIN INFECTED WITH PICHINDE VIRUS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NR 5 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1314 EP A1314 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71902187 ER PT J AU LUGO, S KAMIMORI, GH EDDINGTON, N AF LUGO, S KAMIMORI, GH EDDINGTON, N TI NONLINEAR PHARMACOKINETICS OF INDOCYANINE GREEN (ICG) AFTER REPEATED ADMINISTRATION TO HEALTHY MALE-VOLUNTEERS SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MARYLAND,DEPT PHARMACEUT,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A993 EP A993 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900328 ER PT J AU MATTHEW, C AF MATTHEW, C TI TREATMENT OF HYPERTHERMIA AND DEHYDRATION WITH A HYPERTONIC SOLUTION SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1201 EP A1201 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71901529 ER PT J AU NARAYAN, KA SUNDARAM, S NEIDHARDT, A KUPPERSCHMIDT, J AF NARAYAN, KA SUNDARAM, S NEIDHARDT, A KUPPERSCHMIDT, J TI DIGESTIBILITY OF SOLID FATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,NATICK RES & DEV LABS,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A969 EP A969 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900192 ER PT J AU QIAN, C GUO, ZM PETERS, CJ LIU, CT AF QIAN, C GUO, ZM PETERS, CJ LIU, CT TI PLATELET-ACTIVATING-FACTOR (PAF)-INDUCED CARDIOPULMONARY DYSFUNCTIONS AND THEIR REVERSAL WITH A PAF ANTAGONIST (BN 52021) IN GUINEA-PIGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1315 EP A1315 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71902188 ER PT J AU ROBINSON, CP FRANZ, DR BONDURA, ME AF ROBINSON, CP FRANZ, DR BONDURA, ME TI PALYTOXIN EFFECTS ON PORCINE CORONARY-ARTERY RINGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV OKLAHOMA,HLTH SCI CTR,COLL PHARM,OKLAHOMA CITY,OK 73190. USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1305 EP A1305 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71902133 ER PT J AU ROSE, MS MOORE, R MAHNKE, R CHRISTENSEN, E ASKEW, EW AF ROSE, MS MOORE, R MAHNKE, R CHRISTENSEN, E ASKEW, EW TI WEIGHT-REDUCTION TECHNIQUES ADOPTED WHEN WEIGHT STANDARDS ARE ENFORCED SO FASEB JOURNAL LA English DT Meeting Abstract C1 S DAKOTA STATE UNIV,BROOKINGS,SD 57007. USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1364 EP A1364 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71902473 ER PT J AU SAXENA, A HUR, RS GENTRY, MK DOCTOR, BP AF SAXENA, A HUR, RS GENTRY, MK DOCTOR, BP TI IMMUNOCHEMICAL CHARACTERIZATION OF THE MONOMERIC FORM OF FETAL BOVINE SERUM ACETYLCHOLINESTERASE SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 2 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1016 EP A1016 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900464 ER PT J AU SCHAUDIES, RP AF SCHAUDIES, RP TI INCREASED RENAL EGF FOLLOWING ISCHEMIA IS ASSOCIATED WITH A DECREASE IN MEMBRANE-ASSOCIATED PRECURSORS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1028 EP A1028 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900533 ER PT J AU SMITH, N PARKER, G MCCOMAS, D TAYLOR, T AF SMITH, N PARKER, G MCCOMAS, D TAYLOR, T TI PALYTOXIN AND NG-AMINO-L-ARGININE ABOLISH THE RELAXATION BUT NOT THE CONTRACTILE RESPONSE TO ACETYLCHOLINE IN RAT AORTIC RINGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1256 EP A1256 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71901849 ER PT J AU UYEHARA, CFT MATSUDA, LS SATO, AK CLAYBAUGH, JR AF UYEHARA, CFT MATSUDA, LS SATO, AK CLAYBAUGH, JR TI VASOPRESSIN IMPROVES BLOOD OXYGENATION DURING HYPOXIA IN NEONATAL PIGLETS SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. KAPIOLANI MED CTR,HONOLULU,HI. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1461 EP A1461 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71903037 ER PT J AU WANEBO, J WIESMANN, W MCKINNEY, L PEARCE, F AF WANEBO, J WIESMANN, W MCKINNEY, L PEARCE, F TI LONG-TERM (7-DAY), NONINVASIVE MONITORING OF SKIN FLAP PO2 USING OXYGEN-QUENCHED PHOSPHORESCENCE DECAY MEASUREMENT SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20889. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1059 EP A1059 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71900710 ER PT J AU WHITE, K LINK, H KRZYCH, U AF WHITE, K LINK, H KRZYCH, U TI T-CELL LYMPHOKINES PARTICIPATE IN PROTECTIVE IMMUNITY INDUCED BY IMMUNIZATION WITH RADIATION-ATTENUATED PLASMODIUM-BERGHEI SPOROZOITES SO FASEB JOURNAL LA English DT Meeting Abstract C1 CATHOLIC UNIV AMER,DEPT BIOL,WASHINGTON,DC 20065. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 26 PY 1992 VL 6 IS 4 BP A1220 EP A1220 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA HG719 UT WOS:A1992HG71901640 ER PT J AU AMEMIYA, Y HONG, SS VENKATARAMAN, BV PATIL, PN SHAMS, G ROMSTEDT, K FELLER, DR HSU, FL MILLER, DD AF AMEMIYA, Y HONG, SS VENKATARAMAN, BV PATIL, PN SHAMS, G ROMSTEDT, K FELLER, DR HSU, FL MILLER, DD TI SYNTHESIS AND ALPHA-ADRENERGIC ACTIVITIES OF 2-SUBSTITUTED AND 4-SUBSTITUTED IMIDAZOLINE AND IMIDAZOLE ANALOGS SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID RAT AORTA; RECEPTOR INTERACTIONS; HUMAN-PLATELETS; CATECHOLIMIDAZOLINES; AFFINITY; EFFICACY; CARBON AB Seven analogues of medetomidine and naphazoline were synthesized and evaluated for their alpha(1) (aorta) and alpha(2) (platelet) activities. The analogues were composed of 2- and 4-substituted imidazoles and imidazolines attached through a methylene bridge to either the 1- or 2-naphthalene ring system. In general the 1-naphthalene analogues were the most potent inhibitors of epinephrine-induced platelet aggregation. Of considerable interest was the fact that the 1-naphthalene analogues (2, 5-7) were partial agonists while the 2-naphthalene analogues (3, 8, 9) were antagonists in an alpha(1) adrenergic system (aorta). Thus, appropriately substituted naphthalene analogues of medetomidine and naphthazoline provide a spectrum of alpha(1)-agonist, alpha(1)-antagonist, and alpha(2)-antagonist activity. C1 OHIO STATE UNIV,COLL MED,DIV MED CHEM,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,DIV PHARMACOGNOSY & PHARMACOL,COLUMBUS,OH 43210. USA,CHEM RES,ABERDEEN PROVING GROUND,MD 21010. FU NIGMS NIH HHS [R01GM29358-10] NR 21 TC 19 Z9 19 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD FEB 21 PY 1992 VL 35 IS 4 BP 750 EP 755 DI 10.1021/jm00082a017 PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA HE971 UT WOS:A1992HE97100017 PM 1347319 ER PT J AU CRENSHAW, ME SCALORA, M BOWDEN, CM AF CRENSHAW, ME SCALORA, M BOWDEN, CM TI ULTRAFAST INTRINSIC OPTICAL SWITCHING IN A DENSE MEDIUM OF 2-LEVEL ATOMS SO PHYSICAL REVIEW LETTERS LA English DT Article ID BISTABILITY AB We performed a numerical investigation of the dynamics of the Bloch equations, extended for dense media (media having many atoms within a cubic resonance wavelength), for optical pulses whose duration is much less than an induced-dipole dephasing time. We find a signature of near dipole-dipole interaction which may provide a useful method for validating the first-principles model, for measuring the strength of the interaction, and for coherent pumping. Further, we demonstrate a new and unique optical switching mechanism which may lead to the development of important devices. RP CRENSHAW, ME (reprint author), USA MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI-RD-WS,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 13 TC 92 Z9 95 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD FEB 17 PY 1992 VL 68 IS 7 BP 911 EP 914 DI 10.1103/PhysRevLett.68.911 PG 4 WC Physics, Multidisciplinary SC Physics GA HE195 UT WOS:A1992HE19500004 ER PT J AU GUHA, S KANG, K PORTER, P ROACH, JF REMY, DE ARANDA, FJ RAO, DVGLN AF GUHA, S KANG, K PORTER, P ROACH, JF REMY, DE ARANDA, FJ RAO, DVGLN TI 3RD-ORDER OPTICAL NONLINEARITIES OF METALLOTETRABENZOPORPHYRINS AND A PLATINUM POLY-YNE SO OPTICS LETTERS LA English DT Article ID REVERSE SATURABLE ABSORPTION AB The third-order optical nonlinearities of two metallotetrabenzoporphyrins and a platinum poly-yne dissolved in tetrahydrofuran were measured by using picosecond and nanosecond laser pulses. The pulse-width-dependent measurements indicated that excited-state absorption was present in both classes of material along with nonresonant two-photon absorption. C1 USA,NATICK RES & DEV LABS,CTR DEV & ENGN,NATICK,MA 01760. UNIV MASSACHUSETTS,DEPT PHYS,BOSTON,MA 02125. RP GUHA, S (reprint author), MARTIN MARIETTA CORP LABS,1450 S ROLLING RD,BALTIMORE,MD 21227, USA. RI Rao, Devulapalli/L-8863-2015 NR 14 TC 101 Z9 102 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD FEB 15 PY 1992 VL 17 IS 4 BP 264 EP 266 DI 10.1364/OL.17.000264 PG 3 WC Optics SC Optics GA HD420 UT WOS:A1992HD42000013 PM 19784296 ER PT J AU BOWEN, KJ VUKELJA, SJ AF BOWEN, KJ VUKELJA, SJ TI HYPERCOAGULABLE STATES - THEIR CAUSES AND MANAGEMENT SO POSTGRADUATE MEDICINE LA English DT Article ID PROTEIN-C DEFICIENCY; SYSTEMIC LUPUS-ERYTHEMATOSUS; S DEFICIENCY; CLINICAL-SIGNIFICANCE; BLOOD-COAGULATION; THROMBOSIS; ANTICOAGULANT; PATHOPHYSIOLOGY; ANTITHROMBIN; ANTIBODIES AB A number of hypercoagulable states, both hereditary and acquired, cause or predispose a patient to thromboembolic disease. Drs Bowen and Vukelja offer a useful overview of these clinical conditions, many of which require long-term or lifelong anticoagulant therapy. RP BOWEN, KJ (reprint author), USA,BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 31 TC 2 Z9 2 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD FEB 15 PY 1992 VL 91 IS 3 BP 117 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA HF809 UT WOS:A1992HF80900015 PM 1741357 ER PT J AU HAMILTON, JD HARTIGAN, PM SIMBERKOFF, MS DAY, PL DIAMOND, GR DICKINSON, GM DRUSANO, GL EGORIN, MJ GEORGE, WL GORDIN, FM HAWKES, CA JENSEN, PC KLIMAS, NG LABRIOLA, AM LAHART, CJ OBRIEN, WA OSTER, CN WEINHOLD, KJ WRAY, NP ZOLLAPAZNER, SB AF HAMILTON, JD HARTIGAN, PM SIMBERKOFF, MS DAY, PL DIAMOND, GR DICKINSON, GM DRUSANO, GL EGORIN, MJ GEORGE, WL GORDIN, FM HAWKES, CA JENSEN, PC KLIMAS, NG LABRIOLA, AM LAHART, CJ OBRIEN, WA OSTER, CN WEINHOLD, KJ WRAY, NP ZOLLAPAZNER, SB TI A CONTROLLED TRIAL OF EARLY VERSUS LATE TREATMENT WITH ZIDOVUDINE IN SYMPTOMATIC HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION - RESULTS OF THE VETERANS AFFAIRS COOPERATIVE STUDY SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID PLACEBO-CONTROLLED TRIAL; AIDS-RELATED COMPLEX; DOUBLE-BLIND; AZIDOTHYMIDINE AZT; CLINICAL-TRIALS; EFFICACY; TOXICITY; PATIENT; HIV AB Background. Zidovudine is recommended for asymptomatic and early symptomatic human immunodeficiency virus (HIV) infection. The best time to initiate zidovudine treatment remains uncertain, however, and whether early treatment improves survival has not been established. Methods. We conducted a multicenter, randomized, double-blind trial that compared early zidovudine therapy (beginning at 1500 mg per day) with late therapy in HIV-infected patients who were symptomatic and had CD4+ counts between 0.2 x 10(9) and 0.5 x 10(9) cells per liter (200 to 500 per cubic millimeter) at entry. Those assigned to late therapy initially received placebo and began zidovudine when their CD4+ counts fell below 0.2 x 10(9) per liter (200 per cubic millimeter) or when the acquired immunodeficiency syndrome (AIDS) developed. Results. During a mean follow-up period of more than two years, there were 23 deaths in the early-therapy group (n = 170) and 20 deaths in the late-therapy group (n = 168) (P = 0.48; relative risk [late vs. early], 0.81; 95 percent confidence interval, 0.44 to 1.59). In the early-therapy group, 28 patients progressed to AIDS, as compared with 48 in the late-therapy group (P = 0.02; relative risk, 1.76; 95 percent confidence interval, 1.1 to 2.8). Early therapy increased the time until CD4+ counts fell below 0.2 x l0(9) per liter (200 per cubic millimeter), and it produced more conversions from positive to negative for serum p24 antigen. Early therapy was associated with more anemia, leukopenia, nausea, vomiting, and diarrhea, whereas late therapy was associated with more skin rash. Conclusions. In symptomatic patients with HIV infection, early treatment with zidovudine delays progression to AIDS, but in this controlled study it did not improve survival, and it was associated with more side effects. C1 DEPT VET AFFAIRS MED CTR,BALTIMORE,MD. DEPT VET AFFAIRS MED CTR,HOUSTON,TX. DEPT VET AFFAIRS MED CTR,LOS ANGELES,CA. DEPT VET AFFAIRS MED CTR,MIAMI,FL. DEPT VET AFFAIRS MED CTR,NEW YORK,NY. DEPT VET AFFAIRS MED CTR,SAN FRANCISCO,CA. DEPT VET AFFAIRS MED CTR,WASHINGTON,DC. VET AFFAIRS COORDINATING CTR,W HAVEN,CT. VET AFFAIRS COORDINATING CTR,ALBUQUERQUE,NM. DUKE UNIV,DURHAM,NC 27706. WALTER REED ARMY MED CTR,WASHINGTON,DC. RP HAMILTON, JD (reprint author), DEPT VET AFFAIRS MED CTR,508 FULTON ST,DURHAM,NC 27705, USA. NR 18 TC 330 Z9 330 U1 0 U2 3 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD FEB 13 PY 1992 VL 326 IS 7 BP 437 EP 443 DI 10.1056/NEJM199202133260703 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA HD164 UT WOS:A1992HD16400003 PM 1346337 ER PT J AU MARSHALL, MS BENNER, RE AF MARSHALL, MS BENNER, RE TI SPHERICAL-PARTICLE SIZING BY OPTICAL CORRELATION USING TERNARY PHASE-AMPLITUDE FILTERS SO APPLIED OPTICS LA English DT Article ID RATIO; RECOGNITION AB Computer simulations and experimental data are presented for various ternary phase-amplitude filters used to size opaque spherical particles. We first report on nearly unlimited spatial frequency ternary phase-amplitude filters derived directly from the classical matched filter for opaque spherical particles in the size range of 100 to 400-mu-m. Next we investigate the increasing influence of the cutoff frequency on the optical correlator as the particles become smaller. Using limited-order ternary phase-amplitude filters, we report on sizing opaque spherical particles in the size ranges of 100 to 400, 15 to 100, and 5 to 25-mu-m. C1 UNIV UTAH,DEPT ELECT ENGN,SALT LAKE CITY,UT 84122. RP MARSHALL, MS (reprint author), USA,DUGWAY PROVING GROUND,INSTRUMENTAT BRANCH,DUGWAY PROVING GROUND,UT 84022, USA. NR 12 TC 2 Z9 2 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD FEB 10 PY 1992 VL 31 IS 5 BP 644 EP 651 PG 8 WC Optics SC Optics GA HC500 UT WOS:A1992HC50000010 PM 20720660 ER PT J AU SUN, HJ WATKINS, GD RONG, FC FOTIADIS, L POINDEXTER, EH AF SUN, HJ WATKINS, GD RONG, FC FOTIADIS, L POINDEXTER, EH TI OPTICALLY DETECTED ELECTRON-PARAMAGNETIC RESONANCE OF ARSENIC ANTISITES IN LOW-TEMPERATURE GAAS-LAYERS SO APPLIED PHYSICS LETTERS LA English DT Article ID NUCLEAR DOUBLE-RESONANCE; AS-ANTISITE; DEFECTS; EL2 AB Arsenic antisites in GaAs layers grown by molecular-beam epitaxy at low substrate temperatures (approximately 200-degrees-C) were observed using electron paramagnetic resonance (EPR), magnetic circular dichroism in absorption (MCDA), and MCDA-detected EPR. This observation confirms that there is a MCDA band directly associated with arsenic antisites in the GaAs layers. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. LEHIGH UNIV,DEPT PHYS,BETHLEHEM,PA 18015. RP SUN, HJ (reprint author), LEHIGH UNIV,SHERMAN FAIRCHILD LAB,BETHLEHEM,PA 18015, USA. NR 10 TC 25 Z9 26 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD FEB 10 PY 1992 VL 60 IS 6 BP 718 EP 720 DI 10.1063/1.106548 PG 3 WC Physics, Applied SC Physics GA HC820 UT WOS:A1992HC82000019 ER PT J AU STURM, M JOHNSON, JB AF STURM, M JOHNSON, JB TI THERMAL-CONDUCTIVITY MEASUREMENTS OF DEPTH HOAR SO JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH LA English DT Article AB The effective thermal conductivity of snow (k(eff)), which includes latent heat transfer due to vapor diffusion, was measured during three winters in Fairbanks, Alaska. In 1986-1987, k(eff) of several layers of snow was monitored in detail as the snow metamorphosed into depth hoar. Measurements were made using a needle probe with an estimated accuracy of +/- 8%; k(eff) was found to decrease and then increase as the snow passed from new snow through several distinct stages of depth hoar. For depth hoar, k(eff) ranged from 0.026 to 0.105, with an average value of 0.063 W m-1 K-1. This is one half to one fourth the value suggested by most studies for snow of similar density. For depth hoar of a given type, k(eff) can be represented as a linear function of temperature between 0-degrees and -20-degrees-C but requires a nonlinear function for the range from 0-degrees to -196-degrees-C. At -196-degrees-C the thermal conductivity of depth hoar approached that of still air, suggesting that conduction through the ice skeleton of the snow was limited and that the increase in k(eff) at temperatures near 0-degrees-C is the result of the strong temperature dependence of water vapor density. This conclusion is consistent with the nature of the ice bonds in depth hoar, which are thin and relatively few in number. RP STURM, M (reprint author), USA,COLD REG RES & ENGN LAB,BLDG 4070,FT WAINWRIGHT,AK 99703, USA. NR 51 TC 52 Z9 52 U1 0 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-SOL EA JI J. Geophys. Res.-Solid Earth PD FEB 10 PY 1992 VL 97 IS B2 BP 2129 EP 2139 DI 10.1029/91JB02685 PG 11 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA HD477 UT WOS:A1992HD47700033 ER PT J AU LOOAREESUWAN, S WILAIRATANA, P VANIJANONTA, S KYLE, D WEBSTER, K AF LOOAREESUWAN, S WILAIRATANA, P VANIJANONTA, S KYLE, D WEBSTER, K TI EFFICACY OF QUININE-TETRACYCLINE FOR ACUTE UNCOMPLICATED FALCIPARUM-MALARIA IN THAILAND SO LANCET LA English DT Letter ID PLASMODIUM-FALCIPARUM C1 ARMED FORCES RES INST MED SCI,USA MED COMPONENT,BANGKOK,THAILAND. RP LOOAREESUWAN, S (reprint author), MAHIDOL UNIV,BANGKOK HOSP TROP DIS,FAC TROP MED,BANGKOK 10400,THAILAND. NR 6 TC 46 Z9 47 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD FEB 8 PY 1992 VL 339 IS 8789 BP 369 EP 369 DI 10.1016/0140-6736(92)91690-A PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA HC771 UT WOS:A1992HC77100047 PM 1346445 ER PT J AU CHANG, FCT AF CHANG, FCT TI MODIFICATION OF MEDULLARY RESPIRATORY-RELATED DISCHARGE PATTERNS BY BEHAVIORS AND STATES OF AROUSAL SO BRAIN RESEARCH LA English DT Article DE RESPIRATION; BEHAVIOR; STATE OF AROUSAL; VENTRAL RESPIRATORY GROUP; BOTZINGER COMPLEX; NUCLEUS AMBIGUUS; CHRONIC SINGLE UNIT RECORDING; DIAPHRAGMATIC ELECTROMYOGRAM; GUINEA PIG ID SLEEP-WAKING STATES; GUINEA-PIGS; INSPIRATORY NEURONS; EXPIRATORY NEURONS; CENTRAL NUCLEUS; CAT; INHIBITION; PROJECTIONS; WAKEFULNESS; AMYGDALA AB The modulatory influences of behaviors and states of arousal on bulbar respiratory-related unit (RRU) discharge patterns were studied in an unanesthetized, freely behaving guinea pig respiratory model system. When fully instrumented, this model system permits concurrent monitoring and recording of (i) single units from either Botzinger complex or nucleus para-ambiguus; (ii) electrocorticogram; and, (iii) diaphragmatic EMG. In addition to being used in surveys of RRU discharge patterns in freely behaving states, the model system also offered a unique opportunity in investigating the effects of pentobarbital on RRU discharge patterns before, throughout the course of, and during recovery from anesthesia. In anesthetized preparations, a particular RRU discharge pattern (such as tonic, incrementing or decrementing) typically displayed little, if any notable variation. The most striking development following pentobarbital was a state of progressive bradypnea attributable to a significantly augmented RRU cycle duration, burst duration and an increase in the RRU spike frequencies during anesthesia. In freely behaving states, medullary RRU activities rarely adhered to a fixed, immutable discharge pattern. More specifically, the temporal organization (such as burst duration, cycle duration, and the extent of modulation of within-burst spike frequencies) of RRU discharge patterns regularly showed complex and striking variations, not only with states of arousal (sleep/wakefulness, anesthesia) but also with discrete alterations in electrocorticogram (ECoG) activities and a multitude of on-going behavioral repertories such as volitional movement, postural modification, phonation, mastication, deglutition, sniffing/exploratory behavior, alerting/startle reflexes. Only during sleep, and on occasions when the animal assumed a motionless, resting posture, could burst patterns of relatively invariable periodicity and uniform temporal attributes be observed. RRU activities during sniffing reflex is worthy of further note in that, based on power spectrum analyses of concurrently recorded ECoG activities, this particular discharge pattern was clearly associated with the activation of a 6-10 Hz theta rhythm. These findings indicated that bulbar RRU activity patterns are subject to change by not only behaviors and sleep/wakefulness cycles, but also a variety of modulatory influences and feedback/feedforward biases from other central and peripheral physiological control mechanisms. RP CHANG, FCT (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 40 TC 18 Z9 18 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD FEB 7 PY 1992 VL 571 IS 2 BP 281 EP 292 DI 10.1016/0006-8993(92)90666-W PG 12 WC Neurosciences SC Neurosciences & Neurology GA HE699 UT WOS:A1992HE69900014 PM 1611499 ER PT J AU ARCIDIACONO, S KAPLAN, DL AF ARCIDIACONO, S KAPLAN, DL TI MOLECULAR-WEIGHT DISTRIBUTION OF CHITOSAN ISOLATED FROM MUCOR-ROUXII UNDER DIFFERENT CULTURE AND PROCESSING CONDITIONS SO BIOTECHNOLOGY AND BIOENGINEERING LA English DT Article DE CHITIN; CHITOSAN; MUCOR-ROUXII; POLYSACCHARIDES AB The isolation of chitosan from a fungal source offers the potential of a product with controlled physicochemical properties not obtainable by the commercial chemical conversion of crustacean chitin. A variety of culture and processing protocols using Mucor rouxii were studied for their effects on biomass yield and chitosan molecular weight. Weight-averaged molecular weight determined by gel permeation chromotography ranged from 2.0 x 10(5) to approximately 1.4 x 10(6) daltons. The chitosan yield ranged from 5% to 10% of total biomass dry weight and from 30% to 40% of the cell wall. Of the culture parameters studied, length of incubation and medium composition effected biomass production and molecular weight. Modification of the processing protocol, including the type and strength of acid, and cell wall disruption in acid prior to refluxing were used to optimize the efficiency of chitosan extraction. The degree of deacetylation of fungal and commercial chitosans was compared using infrared spectrometry, titration, and first derivative of UV absorbance spectrometry. The chitosan obtained directly from the fungal cell wall had a higher degree of deacetylation than commercial chitosan from the chemical conversion process. RP ARCIDIACONO, S (reprint author), USA,NATICK RES DEV & E CTR,DIV BIOTECHNOL,NATICK,MA 01760, USA. NR 12 TC 70 Z9 73 U1 1 U2 5 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0006-3592 J9 BIOTECHNOL BIOENG JI Biotechnol. Bioeng. PD FEB 5 PY 1992 VL 39 IS 3 BP 281 EP 286 DI 10.1002/bit.260390305 PG 6 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA HA001 UT WOS:A1992HA00100004 PM 18600943 ER PT J AU KRIEGER, JB LI, Y IAFRATE, GJ AF KRIEGER, JB LI, Y IAFRATE, GJ TI ACCURATE LOCAL SPIN-POLARIZED EXCHANGE POTENTIAL - RECONCILIATION OF GENERALIZED SLATER AND KOHN-SHAM METHODS SO INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY LA English DT Article ID DENSITY-FUNCTIONAL THEORY; ATOMS; ENERGY AB Using simple physical arguments, a local spin-polarized exchange potential, V(x-sigma), is constructed from the single-particle Hartree-Fock (HF) potentials (generalized Slater method) that reduces to the usual Kohn-Sham (KS) result in the uniform gas limit. Numerical results for 10 closed subshell atoms demonstrate that the total energy calculated employing this V(x-sigma) is closer to the exact KS results than those of other standard exchange approximations with electron densities and highest occupied orbital eigenvalues that closely approximate the HF results. C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP CUNY BROOKLYN COLL, DEPT PHYS, BROOKLYN, NY 11210 USA. NR 21 TC 33 Z9 33 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0020-7608 EI 1097-461X J9 INT J QUANTUM CHEM JI Int. J. Quantum Chem. PD FEB 5 PY 1992 VL 41 IS 3 BP 489 EP 496 DI 10.1002/qua.560410311 PG 8 WC Chemistry, Physical; Mathematics, Interdisciplinary Applications; Physics, Atomic, Molecular & Chemical SC Chemistry; Mathematics; Physics GA GW220 UT WOS:A1992GW22000010 ER PT J AU VANCOTT, TC LOOMIS, LD REDFIELD, RR BIRX, DL AF VANCOTT, TC LOOMIS, LD REDFIELD, RR BIRX, DL TI REAL-TIME BIOSPECIFIC INTERACTION ANALYSIS OF ANTIBODY REACTIVITY TO PEPTIDES FROM THE ENVELOPE GLYCOPROTEIN, GP160, OF HIV-1 SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE BIOSPECIFIC INTERACTION ANALYSIS (BIACORE); ANTIBODY-ANTIGEN INTERACTION; POLYCLONAL SERUM; HIV-1; GP160; PEPTIDE; AFFINITY ID VIRUS TYPE-III; SURFACE-PLASMON RESONANCE; HTLV-III/LAV ENVELOPE; T4 MOLECULE; AIDS; RETROVIRUS; NEUTRALIZATION; RECEPTOR; ANTIGEN AB A new assay designed to quantitate antibody reactivity to specific peptides using biospecific interaction analysis (BIAcore) has been developed. Peptides of various lengths (15-40 amino acids) and isoelectric points (pI = 4.5-13) were covalently linked (immobilized) to a biosensor and interacted with polyclonal human sera. The immobilization procedure was highly reproducible, with bound peptides retaining high antibody reactivity. The assay was rapid, requiring only 25-30 min to immobilize the peptide and 2-8 min for each subsequent peptide/serum binding interaction. The same peptide surface has been used for up to 90 cycles of serum binding and regeneration with only a 0.3% decay in reactivity over cycle number. The quantitative BIAcore signal, measuring peptide/antibody binding interactions, was directly related to the antigen/antibody concentrations within the biosensor. The assay allowed interactions to be studied in their native form and without the need of additional secondary detection antibodies. Correlation between conventional peptide ELISA and BIAcore was obtained. The BIAcore linear range persisted over a series of eight two-fold dilutions. This extended linear dynamic response range is an improvement over conventional ELISA measurements. The sensitivity for monoclonal antibody detection is similar to conventional ELISAs and 4.9 ng/ml was readily detected. C1 WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,DIV RETROVIROL,WASHINGTON,DC 20307. NR 31 TC 63 Z9 64 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD FEB 5 PY 1992 VL 146 IS 2 BP 163 EP 176 DI 10.1016/0022-1759(92)90225-I PG 14 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA HD576 UT WOS:A1992HD57600003 PM 1538140 ER PT J AU CHOI, KK FOTIADIS, L TAYSINGLARA, M CHANG, W IAFRATE, GJ AF CHOI, KK FOTIADIS, L TAYSINGLARA, M CHANG, W IAFRATE, GJ TI INFRARED-ABSORPTION AND PHOTOCONDUCTIVE GAIN OF QUANTUM-WELL INFRARED PHOTODETECTORS SO APPLIED PHYSICS LETTERS LA English DT Article AB We have conducted a detailed study on the properties of a multiple quantum well infrared photodetector (QWIP) with a single bound state. From the optical absorption experiment, we found that the peak absorption energy is determined by the resonant states associated with each individual well and not by the global miniband structure. From the transport experiment, we observed that the photoelectron distribution over the QWIP is extremely narrow and close to the top of the quantum well barriers, indicative of the diffusive nature of the hot-electron transport in this structure. At large bias, the photoelectron distribution begins to shift up in energy, and is found strongly correlated to the observed photoconductive gain of the detector. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP CHOI, KK (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 10 TC 18 Z9 18 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD FEB 3 PY 1992 VL 60 IS 5 BP 592 EP 594 DI 10.1063/1.106591 PG 3 WC Physics, Applied SC Physics GA HB582 UT WOS:A1992HB58200025 ER PT J AU RONG, FC GERARDI, GJ BUCHWALD, WR POINDEXTER, EH UMLOR, MT KEEBLE, DJ WARREN, WL AF RONG, FC GERARDI, GJ BUCHWALD, WR POINDEXTER, EH UMLOR, MT KEEBLE, DJ WARREN, WL TI ELECTRICALLY DETECTED MAGNETIC-RESONANCE OF A TRANSITION-METAL RELATED RECOMBINATION CENTER IN SI P-N DIODES SO APPLIED PHYSICS LETTERS LA English DT Article ID SPIN-DEPENDENT RECOMBINATION; SILICON; PLATINUM; JUNCTION AB A hyperfine structure has been observed by electrically detected magnetic resonance from a Si p-n diode. From the hyperfine splitting, and the natural abundance of the interacting I = 1/2 nuclear species, the recombination center is found to be consistent with a platinum complex. C1 MICHIGAN TECHNOL UNIV,DEPT PHYS,HOUGHTON,MI 49931. SANDIA NATL LABS,ALBUQUERQUE,NM 87185. RP RONG, FC (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,GEOCTR INC,FT MONMOUTH,NJ 07703, USA. RI Keeble, David /C-6633-2012 OI Keeble, David /0000-0002-5378-799X NR 14 TC 30 Z9 30 U1 1 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD FEB 3 PY 1992 VL 60 IS 5 BP 610 EP 612 DI 10.1063/1.106569 PG 3 WC Physics, Applied SC Physics GA HB582 UT WOS:A1992HB58200031 ER PT J AU SINGLETON, RE AF SINGLETON, RE TI CFD JOINS THE ARMY SO AEROSPACE AMERICA LA English DT Article RP SINGLETON, RE (reprint author), USA,RES OFF,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0740-722X J9 AEROSPACE AM JI Aerosp. Am. PD FEB PY 1992 VL 30 IS 2 BP 22 EP 26 PG 5 WC Engineering, Aerospace SC Engineering GA HD315 UT WOS:A1992HD31500006 ER PT J AU HALL, P SEDNEY, R GERBER, N AF HALL, P SEDNEY, R GERBER, N TI HIGH REYNOLDS-NUMBER FLOWS IN ROTATING AND NUTATING CYLINDERS - SPATIAL EIGENVALUE APPROACH SO AIAA JOURNAL LA English DT Article ID MOTION; FLUID AB The spatial eigenvalue expansion procedure that we have used previously to study viscous flow in rotating and nutating cylinders is studied in the high Reynolds number limit. It is shown that in this limit there is a significant simplification in the procedure employed to determine the amplitudes of the eigenfunctions used to describe the forced velocity field in the cylinder. More precisely, it is shown that these amplitudes can, to the order of Reynolds number used in this paper, be simply expressed in terms of Bessel functions. The method is used to calculate the pressure coefficient at a point on the end wall. Detailed comparisons with experimental results are made. It is found that the approach provides an accurate and extremely rapid way of determining this pressure coefficient. C1 USA,BALLIST RES LABS,DIV LAUNCH & FLIGHT,ABERDEEN PROVING GROUND,MD 21005. RP HALL, P (reprint author), UNIV MANCHESTER,MATH,MANCHESTER M13 9PL,LANCS,ENGLAND. NR 13 TC 1 Z9 3 U1 0 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD FEB PY 1992 VL 30 IS 2 BP 423 EP 430 DI 10.2514/3.10933 PG 8 WC Engineering, Aerospace SC Engineering GA HE967 UT WOS:A1992HE96700018 ER PT J AU FRANCIS, ML MELTZER, MS GENDELMAN, HE AF FRANCIS, ML MELTZER, MS GENDELMAN, HE TI INTERFERONS IN THE PERSISTENCE, PATHOGENESIS, AND TREATMENT OF HIV-INFECTION SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; PLACEBO-CONTROLLED TRIAL; BLOOD MONONUCLEAR-CELLS; HERPES-SIMPLEX VIRUS; DOUBLE-STRANDED-RNA; CHRONIC HEPATITIS-C; KAPOSIS SARCOMA; IFN-ALPHA; MESSENGER-RNA; FIBRONECTIN DISTRIBUTION AB Interferon (IFN) plays an important role in the treatment and pathogenesis of HIV disease. Recent studies show beneficial effects of IFN-alpha in the treatment of HIV-associated Kaposi's Sarcoma and early HIV-infection. Moreover, cell culture studies support these beneficial effects. HIV infection of monocytes is blocked by IFN-alpha administered at the time of viral challenge. The IFN-alpha-treated cells show no evidence of HIV infection. Viral gene products produced in monocytes infected with HIV then treated with IFN-alpha gradually decrease to baseline. Large quantities of proviral DNA are seen in the HIV-infected IFN-alpha-treated cells with little evidence for viral transcription suggesting true microbiological latency. While most viral infections of cells result in IFN production, HIV is a notable exception. Indeed, HIV does not induce monocytes to produce IFN-alpha and blocks its production following poly(I).poly(c) stimulation. This allows HIV yet another mechanism to evade an important host antiviral response. Paradoxically, the appearance of IFN activity in sera of HIV-infected patients is associated with disease progression, not resolution. Recent observations showing that the interaction between HIV-infected monocytes and PBMC results in the production of IFN-alpha-s with reduced anti-HIV activity may help explain this paradox. Thus, IFN-alpha plays an important but complex role in HIV disease. The elucidation of cellular factors that regulate the antiretroviral effects of IFN-alpha may lead to the development of novel therapeutic strategies for HIV infection. C1 HENRY M JACKSON FDN ADV MIL MED,ROCKVILLE,MD 20805. RP FRANCIS, ML (reprint author), WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,HIV IMMUNOPATHOGENESIS PROGRAM,9620 MED CTR DR,ROCKVILLE,MD 20805, USA. NR 68 TC 133 Z9 133 U1 0 U2 4 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD FEB PY 1992 VL 8 IS 2 BP 199 EP 207 DI 10.1089/aid.1992.8.199 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA HG489 UT WOS:A1992HG48900011 PM 1371692 ER PT J AU DIEHL, AM SHI, QY BROWN, N SMITH, J RAIFORD, D GORDON, R CASERO, R AF DIEHL, AM SHI, QY BROWN, N SMITH, J RAIFORD, D GORDON, R CASERO, R TI ETHANOL-ASSOCIATED ALTERATIONS IN THE KINETICS OF PUTRESCINE UPTAKE AND METABOLISM BY THE REGENERATING LIVER SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE PUTRESCINE; POLYAMINES; LIVER REGENERATION; ORNITHINE DECARBOXYLASE ID AFFINITY GABA UPTAKE; ORNITHINE DECARBOXYLASE; HEPATIC REGENERATION; RAT-LIVER; INHIBITION; POLYAMINE; GROWTH; DIFLUOROMETHYLORNITHINE; LOCALIZATION; REVERSAL AB Biosynthesis of the polyamines, putrescine, spermidine, and spermine is required for DNA synthesis and liver regeneration after partial hepatectomy. We have previously reported that chronic ethanol consumption impairs polyamine synthesis and significantly retards liver regeneration after partial hepatectomy. In those studies, supplementation with putrescine restored hepatic DNA synthesis in ethanol-fed rats but exerted no effect in pair-fed controls. These differences in the response to putrescine treatment may have resulted from ethanol-associated differences in hepatic uptake, release, or metabolism of putrescine. To resolve these issues and define more completely how putrescine treatment affects DNA synthesis, we now assess the kinetics of putrescine uptake and metabolism after intraperitoneal or intravenous injection of radiolabeled putrescine (1.2 mmol/kg, specific activity 1-mu-Ci/mmol) into rats fed 36% ethanol diets or isocaloric, nonethanol diets for 6 weeks prior to partial hepatectomy. After putrescine treatment, hepatic putrescine concentrations were greater in ethanol-fed rats than controls. Differences in post-treatment hepatic putrescine levels between ethanol and pair-fed groups could not be explained by differences in the rates of hepatic putrescine uptake or excretion into bile; residual de novo synthesis of putrescine from ornithine or metabolism of hepatic putrescine to its polyamine products, spermidine and spermine. Indeed, supplemental putrescine was not appreciably converted to spermidine or spermine in either ethanol or control rats. Hence, these latter polyamines are unlikely to be responsible for the treatment-associated improvement in DNA synthesis that has been noted in ethanol-fed rats. This suggests that putrescine itself acts to restore hepatic DNA synthesis in ethanol-fed rats. C1 JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,DIV BIOCHEM,WASHINGTON,DC 20307. FU NIAAA NIH HHS [AA08260-03] NR 28 TC 6 Z9 6 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0145-6008 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD FEB PY 1992 VL 16 IS 1 BP 5 EP 10 DI 10.1111/j.1530-0277.1992.tb00626.x PG 6 WC Substance Abuse SC Substance Abuse GA HE666 UT WOS:A1992HE66600002 PM 1558302 ER PT J AU FILLINGKATZ, MR LEVIN, SW PATRONAS, NJ KATZ, NNK AF FILLINGKATZ, MR LEVIN, SW PATRONAS, NJ KATZ, NNK TI TERMINAL TRANSVERSE LIMB DEFECTS ASSOCIATED WITH FAMILIAL CAVERNOUS ANGIOMATOSIS SO AMERICAN JOURNAL OF MEDICAL GENETICS LA English DT Article DE FAMILIAL CAVERNOUS ANGIOMATOSIS; ANGIOMAS; DISRUPTION; LIMB DEFECT ID VASCULAR ABNORMALITIES; SCALP DEFECTS; MALFORMATIONS; DISRUPTION; HEMANGIOMA; ANOMALIES; POLAND; RETINA AB Terminal transverse limb defects rarely are reported as familial. Multiple pathogenetic mechanisms, including vascular disruption, have been proposed to account for these defects. We report on a family followed over the past 6 years known to have familial cavernous angiomatosis in which 2 relatives have similar terminal transverse defects at the mid-forearm. Multiple relatives have had episodic bleeding from intracranial cavernous angiomas, a distinct finding in this disorder. Other findings in this family include retinal cavernous angiomas (2 patients), a high incidence of skin angiomas (12 patients), cavernous angiomas of the soft tissue (2 patients), and a hepatic angioma (one patient). One of the 2 individuals with the limb defect was evaluated extensively. Magnetic resonance imaging of the forearm with the terminal transverse defect using gadolinium-DTPA enhancement showed abrupt termination of all structures distal to the normal radial and ulnar heads. We propose that familial cavernous angiomatosis may be a new cause of vascular disruption resulting in terminal transverse limb defects. C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,EXCEPT FAMILY MEMBER PROGRAM,BLDG 38,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,DIV OPHTHALMOL,BETHESDA,MD 20814. NIH,WARREN G MAGNUSON CLIN CTR,DEPT RADIOL,BETHESDA,MD 20892. NIAAA,NEUROGENET LAB,BETHESDA,MD. NICHHD,HUMAN GENET BRANCH,BETHESDA,MD 20892. NR 31 TC 12 Z9 12 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0148-7299 J9 AM J MED GENET JI Am. J. Med. Genet. PD FEB 1 PY 1992 VL 42 IS 3 BP 346 EP 351 DI 10.1002/ajmg.1320420319 PG 6 WC Genetics & Heredity SC Genetics & Heredity GA HA737 UT WOS:A1992HA73700018 PM 1536177 ER PT J AU COMPTON, AM MEYERS, CE HONDRUM, SO LORTON, L AF COMPTON, AM MEYERS, CE HONDRUM, SO LORTON, L TI COMPARISON OF THE SHEAR BOND STRENGTH OF A LIGHT-CURED GLASS IONOMER AND A CHEMICALLY CURED GLASS IONOMER FOR USE AS AN ORTHODONTIC BONDING AGENT SO AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS LA English DT Article ID CEMENTS; ENAMEL; DENTIN AB Light-cured glass ionomers with an initial set of 20 seconds may produce higher initial bond strengths, as well as decreased sensitivity to moisture contamination and desiccation, than chemically cured glass ionomers making them attractive for use as orthodontic bonding agents. The purpose of this study was to determine and compare the shear bond strength of stainless steel orthodontic attachments to enamel with a light-cured glass ionomer (Zionomer) tested at 60 minutes and 24 hours, and a rapidly setting chemically cured glass ionomer (Ketac-Bond) tested at 60 minutes and 24 hours. Fifty-two recently extracted human premolars were randomly divided into four groups- 1-hour and 24-hour light-cured glass ionomer groups and 1-hour and 24-hour chemically cured glass ionomer groups. Stainless steel lingual buttons were bonded to prepared enamel surfaces, and the samples were placed in a water bath at 37-degrees-C until ready for testing. The shear bond strength of each sample was determined with a universal testing instrument. Results from the study conclude: (1) The mean shear bond strength of the light-cured glass ionomer is greater than that of the chemically cured glass ionomer at 1 and 24 hours. (2) The mean shear bond strength of both glass ionomers increases from 1 to 24 hours. (3) The mean shear bond strength of the light-cured glass ionomer is not significantly different from 1 to 24 hours, but the shear bond strength of the chemically cured glass ionomer cement is different. The faster setting reaction of the light-cured glass ionomer and its higher initial and sustained bond strength make it more attractive for use as an orthodontic bonding agent. C1 USA ORTHODONT RESIDENCY PROGRAM,FT GEORGE G MEADE,MD. USA,INST DENT RES,FT GEORGE G MEADE,MD. HENRY M JACKSON FDN,ROCKVILLE,MD. RP COMPTON, AM (reprint author), USA,DENTAC,DENT CLIN 5,FT RILEY,KS 66442, USA. NR 33 TC 34 Z9 34 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0889-5406 J9 AM J ORTHOD DENTOFAC JI Am. J. Orthod. Dentofac. Orthop. PD FEB PY 1992 VL 101 IS 2 BP 138 EP 144 DI 10.1016/0889-5406(92)70005-U PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HD747 UT WOS:A1992HD74700009 PM 1739068 ER PT J AU HINKES, MJ AF HINKES, MJ TI MORTAL REMAINS - A TRUE STORY OF RITUAL MURDER - SCAMMELL,H SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY LA English DT Book Review RP HINKES, MJ (reprint author), USA,CENT IDENTIFICAT LAB,FT KAMEHAMEHA,BLDG 45,HICKAM AFB,HI, USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0002-9483 J9 AM J PHYS ANTHROPOL JI Am. J. Phys. Anthropol. PD FEB PY 1992 VL 87 IS 2 BP 237 EP 238 DI 10.1002/ajpa.1330870212 PG 2 WC Anthropology; Evolutionary Biology SC Anthropology; Evolutionary Biology GA HA023 UT WOS:A1992HA02300011 ER PT J AU MEYER, CA COLON, E PROVOST, T SHERMAN, JL AF MEYER, CA COLON, E PROVOST, T SHERMAN, JL TI DELINEATION OF SURGICAL SEGMENTAL LIVER ANATOMY - VALUE OF PRISE, AN MR FAST-SCANNING TECHNIQUE SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Note ID RESECTION; SURGERY C1 PICKER INT,SEQUENCE DEV GRP,HIGHLAND HTS,OH 44143. MAGNET IMAGING VIRGINIA,FALLS CHURCH,VA 22043. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL,BETHESDA,MD 20814. RP MEYER, CA (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307, USA. NR 8 TC 7 Z9 7 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD FEB PY 1992 VL 158 IS 2 BP 299 EP 301 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA HB058 UT WOS:A1992HB05800012 PM 1729785 ER PT J AU COLEMAN, RE CLAVIN, AM MILHOUS, WK AF COLEMAN, RE CLAVIN, AM MILHOUS, WK TI GAMETOCYTOCIDAL AND SPORONTOCIDAL ACTIVITY OF ANTIMALARIALS AGAINST PLASMODIUM-BERGHEI ANKA IN ICR MICE AND ANOPHELES-STEPHENSI MOSQUITOS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID BLOOD SCHIZONTOCIDAL ACTION; RODENT MALARIA; P-BERGHEI; PRIMAQUINE; CHEMOTHERAPY; RESISTANCE; DRUG; FLOXACRINE; YOELII; ACID AB The gametocytocidal and sporontocidal activity of three 8-aminoquinolines (primaquine, WR-238605, and WR-242511), three dihydroacridine-diones (floxacrine, WR-250547, and WR-250548), a 1,4-naphthoquinone (menoctone), a synthetic aminoalcohol (halofantrine), and a guanide (WR-182393) was determined against a cloned line of Plasmodium berghei ANKA. Gametocytocidal activity was assessed by treating mice with a single intraperitoneal inoculation of a given compound (25 mg base drug/kg mouse body weight) four days after the mice were infected with P. berghei. Thin blood smears were made every other day, and the percent parasitemia and macrogametocyte and microgametocyte rates were determined. Floxacrine, menoctone, WR-242511, WR-250547, and WR-250548 effectively cleared sexual and asexual parasites from the peripheral circulation within six days of drug administration. Halofantrine, primaquine, WR-182393, and WR-238605 were ineffective at clearing P. berghei ANKA from circulating erythrocytes at the doses tested; however, mice survival time increased markedly with these compounds when compared with the controls. Significant numbers of macrogametocytes and microgametocytes were present throughout the duration of the infection in mice treated with halofantrine, primaquine, WR-182393, and WR-238605. Sporontocidal activity was evaluated by allowing Anopheles stephensi mosquitoes to feed on P. berghei-infected mice 90 min after treatment with a particular drug. Halofantrine and WR-182393 exhibited no sporontocidal activity, while floxacrine, menoctone, primaquine, WR-238605, WR-242511, WR-250547, and WR-250548 exhibited significant activity. Minimum effective doses (mg base drug/kg of mouse body weight) that prevented mosquitoes from developing sporozoite-infected salivary glands were 0.1563 mg/kg for WR-250547, 0.625 mg/kg for menoctone, 1.25 mg/kg for primaquine, 10 mg/kg for floxacrine, 10 mg/kg for WR-242511, 10 mg/kg for WR-250548, and 25 mg/kg for WR-238605. C1 WALTER REED ARMY MED CTR,DEPT PARASITOL,WASHINGTON,DC 20307. RP COLEMAN, RE (reprint author), WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 58 TC 38 Z9 38 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1992 VL 46 IS 2 BP 169 EP 182 PG 14 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA HH014 UT WOS:A1992HH01400012 PM 1539752 ER PT J AU ELSON, HF GENTRY, MK DOCTOR, BP AF ELSON, HF GENTRY, MK DOCTOR, BP TI A MICROTITER ASSAY FOR DETERMINING PROTEIN, ACETYLCHOLINESTERASE ACTIVITY, AND G418 (NEOMYCIN) RESISTANCE IN CULTURED-CELLS SO ANALYTICAL BIOCHEMISTRY LA English DT Article ID DYE-BINDING; QUANTITATION; FRACTIONS; SDS C1 NHLBI, MOLEC BIOL LAB, BETHESDA, MD 20892 USA. RP WALTER REED ARMY MED CTR, DEPT BIOCHEM, WASHINGTON, DC 20307 USA. NR 17 TC 4 Z9 4 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 EI 1096-0309 J9 ANAL BIOCHEM JI Anal. Biochem. PD FEB 1 PY 1992 VL 200 IS 2 BP 268 EP 272 DI 10.1016/0003-2697(92)90464-I PG 5 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA HB926 UT WOS:A1992HB92600010 PM 1378703 ER PT J AU MARTIN, TW SEAWORTH, JF JOHNS, JP PUPA, LE CONDOS, WR AF MARTIN, TW SEAWORTH, JF JOHNS, JP PUPA, LE CONDOS, WR TI COMPARISON OF ADENOSINE, DIPYRIDAMOLE, AND DOBUTAMINE IN STRESS ECHOCARDIOGRAPHY SO ANNALS OF INTERNAL MEDICINE LA English DT Article DE ECHOCARDIOGRAPHY; DOBUTAMINE; DIPYRIDAMOLE; ADENOSINE; EXERCISE TEST ID CORONARY-ARTERY DISEASE; ACUTE MYOCARDIAL-INFARCTION; EFFORT ANGINA-PECTORIS; PHYSIOLOGIC BASIS; VASCULAR-SURGERY; CARDIAC RISK; EXERCISE; DIAGNOSIS; HYPEREMIA; TL-201 AB Objective: To compare adenosine, dipyridamole, and dobutamine in stress echocardiography with regard to sensitivity, specificity, accuracy, and side effects. Design: Crossover, blinded comparison, with coronary angiography serving as the criterion standard. Setting: U.S. Army tertiary care hospital. Participants: Forty participants, 25 with coronary disease and 15 without coronary disease. Patients were eligible if they had coronary angiography within 6 weeks of stress testing or if they had a risk for coronary disease of less than 5%. Measurements: Left ventricular wall motion was recorded after dobutamine (0.38 mg/kg body weight), adenosine (0.84 mg/kg body weight), and dipyridamole (0.84 mg/kg body weight) stress testing. Stress echocardiographic evaluation was considered to be abnormal if the patient developed new or progressive wall motion abnormalities. The rate of side effects for the types of echocardiography and the patient preference were recorded. Main Results: The sensitivity of dobutamine stress echocardiography (76%; 95% Cl, 59% to 93%) was significantly higher than that of adenosine echocardiography (40%; Cl, 21% to 59%; P < 0.001) and that of dipyridamole echocardiography (56%; Cl, 37% to 75%; P = 0.019). The specificity of adenosine testing (93%; Cl, 80% to 100%) was significantly higher than that of dobutamine echocardiography (60%; Cl, 35% to 85%; P = 0.008) and that of dipyridamole echocardiography (67%; Cl, 43% to 91 %; P = 0.028). Symptoms were more frequent with adenosine echocardiography (100%) than with dipyridamole (88%; P< 0.001) or dobutamine (80%; P < 0.001) echocardiography. Treatment for persistent symptoms was required in more patients after dipyridamole echocardiography (40%) than after dobutamine (12%; P < 0.001) or adenosine (0%; P < .001) echocardiography. More patients preferred dobutamine (48%) or dipyridamole (40%) echocardiography to adenosine echocardiography (12%; P < .001). Conclusions: Dobutamine stress echocardiography is more sensitive and is better tolerated than adenosine or dipyridamole stress echocardiography. Adenosine echocardiography is more specific than dobutamine or dipyridamole echocardiography and is less likely to cause persistent symptoms. C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 30 TC 155 Z9 157 U1 0 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD FEB 1 PY 1992 VL 116 IS 3 BP 190 EP 196 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA HB356 UT WOS:A1992HB35600003 PM 1728203 ER PT J AU KORTEPETER, C MACMILLAN, M FERRELL, R AF KORTEPETER, C MACMILLAN, M FERRELL, R TI POSSIBLE SHORT-TERM-MEMORY LOSS ASSOCIATED WITH NAFARELIN ACETATE SO ANNALS OF PHARMACOTHERAPY LA English DT Article AB OBJECTIVE AND DESIGN: A survey was conducted to determine the occurrence of short-term memory loss in patients using nafarelin acetate nasal spray. SETTING AND PATIENTS: A list of all patients receiving nafarelin acetate from our pharmacy over a four-month period was generated. We contacted and surveyed 16 women. INTERVENTIONS: Each patient was asked to repeat three words at the beginning of the survey and after a series of questions, each patient was asked to recall the three words. Patients were also asked if they believed that their memory was affected by nafarelin acetate nasal spray. RESULTS: Eleven patients (69 percent) recalled three words, 3 (19 percent) recalled two words, and 2 (13 percent) recalled one word at the conclusion of the survey. Nine of 16 patients (56 percent) reported some type of memory difficulty. CONCLUSIONS: Nafarelin acetate nasal spray may adversely affect short-term memory. This effect is not documented in current literature and further investigation is warranted in the possible relationship between gonadotropin releasing hormone agonists, estrogen deficiency, menopause, and short-term memory. Our survey also demonstrates the significance of communication between pharmacists and patients on newly marketed medications. C1 UNIV HAWAII,SCH NURSING,HONOLULU,HI 96822. UNIV PACIFIC,SCH PHARM,STOCKTON,CA 95211. MADIGAN ARMY MED CTR,TACOMA,WA 98431. RP KORTEPETER, C (reprint author), TRIPLER ARMY MED CTR,PHARM SERV HSHK PY,HONOLULU,HI 96859, USA. NR 5 TC 7 Z9 7 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD FEB PY 1992 VL 26 IS 2 BP 169 EP 171 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA HF079 UT WOS:A1992HF07900003 PM 1532517 ER PT J AU EDWARDS, FH WESTON, L AF EDWARDS, FH WESTON, L TI SURGICAL-MANAGEMENT OF POSTEROSEPTAL ACCESSORY ATRIOVENTRICULAR PATHWAYS SO ANNALS OF THORACIC SURGERY LA English DT Article ID PARKINSON-WHITE SYNDROME; CLOSED-HEART TECHNIQUE; EPICARDIAL APPROACH; KENT BUNDLES; EXPERIENCE; TACHYARRHYTHMIAS AB From October 1988 through January 1991, 22 consecutive patients with Wolff-Parkinson-White syndrome underwent surgical ablation of symptomatic accessory posteroseptal atrioventricular pathways at our institution. As our experience with posteroseptal tracts accumulated, we found that surgical technique was logically dictated by the presence of free wall tracts and the exact location of the posteroseptal tract. Accordingly, we developed an operative approach that involves the selective use of endocardial, epicardial, and cryoablation techniques depending on the anatomic location of accessory tracts. This selective approach allows one to exploit the advantages of each technique while minimizing associated disadvantages. There were 14 men and 8 women with an average age of 25 years (range, 19 to 39 years). All patients had symptomatic tachyarrhythmias caused by accessory atrioventricular pathway(s). Most required several antiarrhythmic medications and 17 (77%) had poor arrhythmia control despite maximal medical therapy. Twelve patients had two accessory pathways and 3 also had dual atrioventricular nodal pathways. There were no early or late deaths. In 2 patients, a delta wave associated with a free wall tract reappeared 3 to 5 days after the initial operation, necessitating a second operation which successfully eliminated the accessory tract. All posteroseptal tracts were successfully eliminated during the initial operation. All patients were relieved of symptoms and are now free of medical therapy. Each patient has undergone a postoperative electrophysiologic study which confirms the absence of posteroseptal accessory conduction. The selective approach has been totally successful in our hands and should prove useful to those interested in optimizing the efficiency of surgical procedures for Wolff-Parkinson-White syndrome. C1 WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. NR 17 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD FEB PY 1992 VL 53 IS 2 BP 321 EP 325 PG 5 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA HB907 UT WOS:A1992HB90700025 PM 1731676 ER PT J AU OSTROW, RS FORSLUND, KM MCGLENNEN, RC SHAW, DP SCHLIEVERT, PM USSERY, MA HUGGINS, JW FARAS, AJ AF OSTROW, RS FORSLUND, KM MCGLENNEN, RC SHAW, DP SCHLIEVERT, PM USSERY, MA HUGGINS, JW FARAS, AJ TI RIBAVIRIN MITIGATES WART GROWTH IN RABBITS AT EARLY STAGES OF INFECTION WITH COTTONTAIL RABBIT PAPILLOMAVIRUS SO ANTIVIRAL RESEARCH LA English DT Article DE PAPILLOMAVIRUS; RIBAVIRIN; RABBIT; WART INHIBITION ID AEROSOL TREATMENT; VIRUS-INFECTION; VIRAL-DNA; INFLUENZA; CANCER; CARCINOMAS; INVITRO; CLONING; TUMORS; AGENT AB The challenge to develop antiviral agents effective against DNA viruses such as human papillomavirus (HPV) has been dependent on finding an animal model which mimics the human forms of the disease. We have used an existing model system for the purpose of measuring the effect of antiviral drugs on the inhibition of growth of these lesions. This was based upon domestic rabbits which efficiently grow cutaneous papillomas (warts) when infected with cottontail rabbit papillomavirus (CRPV). One agent which had shown significant success in achieving these goals was ribavirin. Ribavirin was administered intradermally shortly prior to infection at multiple sites with CRPV. Following daily injections of this drug for eight weeks, we have shown a dose-dependent response which had markedly reduced the number of warts, the time of first appearance of warts and reduced the tumor mass as compared to placebo-treated control animals. At the highest dose of ribavirin tested, 30 mg/kg/day, compared to controls, the average reduction in the number of warts was 52%, the average time of first appearance of warts was 49% longer, and the average mass of the warts was reduced by 98%. No detectable antibodies to CRPV were observed in any of the animals. The only side effects which were observed was focal alopecia, and a decrease in body growth upon prolonged treatment, both of which were completely reversible. Pharmacokinetic studies established the metabolism of ribavirin over a 24-h period of time. Ribavirin administered beginning 12 or 30 days post-infection, while not reducing the number of warts, slightly retarded the growth of warts as determined by date of first appearance of warts and mass of warts. C1 UNIV MINNESOTA,SCH MED,DEPT MICROBIOL,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,SCH MED,DEPT LAB MED & PATHOL,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,COLL VET MED,DEPT VET DIAGNOST INVEST,ST PAUL,MN 55108. US FDA,ROCKVILLE,MD 20857. USA,INFECT DIS RES INST,FREDERICK,MD 21701. RP OSTROW, RS (reprint author), UNIV MINNESOTA,SCH MED,INST HUMAN GENET,BOX 206 UMHC,HARVARD ST & E RIVER RD,MINNEAPOLIS,MN 55455, USA. FU PHS HHS [N01-A1-82688] NR 40 TC 17 Z9 18 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD FEB PY 1992 VL 17 IS 2 BP 99 EP 113 DI 10.1016/0166-3542(92)90045-7 PG 15 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA HC243 UT WOS:A1992HC24300001 PM 1313222 ER PT J AU KRAMER, FM ROCK, K ENGELL, D AF KRAMER, FM ROCK, K ENGELL, D TI EFFECTS OF TIME OF DAY AND APPROPRIATENESS ON FOOD-INTAKE AND HEDONIC RATINGS AT MORNING AND MIDDAY SO APPETITE LA English DT Article ID SELECTION RP KRAMER, FM (reprint author), USA,CTR RES DEV & ENGN,STRNC YBF,NATICK,MA 01760, USA. NR 10 TC 36 Z9 36 U1 1 U2 5 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0195-6663 J9 APPETITE JI Appetite PD FEB PY 1992 VL 18 IS 1 BP 1 EP 13 DI 10.1016/0195-6663(92)90206-L PG 13 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA HF131 UT WOS:A1992HF13100001 PM 1562198 ER PT J AU SMITH, KJ SKELTON, HG YEAGER, J ANGRITT, P WAGNER, K JAMES, WD GIBLIN, WJ LUPTON, GP AF SMITH, KJ SKELTON, HG YEAGER, J ANGRITT, P WAGNER, K JAMES, WD GIBLIN, WJ LUPTON, GP TI CUTANEOUS HISTOPATHOLOGIC, IMMUNOHISTOCHEMICAL, AND CLINICAL MANIFESTATIONS IN PATIENTS WITH HEMOPHAGOCYTIC SYNDROME SO ARCHIVES OF DERMATOLOGY LA English DT Article ID CYTOPHAGIC HISTIOCYTIC PANNICULITIS; SIMULATING MALIGNANT HISTIOCYTOSIS; T-CELL LEUKEMIA; SYSTEMIC HISTIOCYTOSIS; LYMPHOMA; INTERLEUKIN-2; IMMUNOTHERAPY; MARKERS; INVITRO; CANCER AB Background and Design. - the hemophagocytic syndrome (HPS) is characterized by fever, wasting, generalized lymphadenopathy, hepatosplenomegaly, and pancytopenia, often with associated coagulopathy. The most common cutaneous manifestations are panniculitis and purpura. Cytophagic histiocytic panniculitis fits within the spectrum of HPS, and the most consistent histopathologic feature in HPS is a proliferation of mature histiocytes that exhibit prominent erythrophagocytosis and cytophagocytosis. The clinical spectrum, the underlying causes, and the histopathologic features found in HPS are broad. The characteristic phagocytic histiocytes seen in HPS have been confused with malignant histiocytes in the past, but are now known to be reactive. The clinical findings, histologic, and immunohistochemical features of 10 cases of HPS with cutaneous lesions were reviewed. Immunohistochemical markers included KP-1, beta-F-1, UCHL-1, L-26, MAC-387, factor XIIIa, and S100 protein. Results. - The HPS was associated with T-cell lymphoma and/or viral infection. Most biopsy specimens showed edema and hemorrhage with a lymphohistiocytic infiltrate and prominent histiocytic cells showing erythrophagocytosis and, in some cases, cytophagocytosis. The histiocytic cells showed positive reactions for KP-1 and negative reactions for the lmphoid markers. In all cases the lymphoid cells showed a mixed pattern with most cells positive for beta-F-1 and UCHL-1, and a small percentage positive for L-26. Conclusion. - In HPS, the prominent phagocytic histiocytes are reactive and are stimulated by T-cell lymphocytes, either neoplastic or in response to viral infection. Many of the findings in the HPS may also be due directly or indirectly to cytokines produced by proliferating T-cell lymphocytes and/or reactive phagocytic histiocytes. C1 ARMED FORCES INST PATHOL, DEPT DERMATOL, WASHINGTON, DC 20306 USA. ARMED FORCES INST PATHOL, AIDS REGISTRY, WASHINGTON, DC 20306 USA. WALTER REED ARMY MED CTR, DEPT DERMATOL, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20814 USA. NATL NAVAL MED CTR, HENRY M JACKSON FDN, BETHESDA, MD 20814 USA. NR 45 TC 48 Z9 52 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD FEB PY 1992 VL 128 IS 2 BP 193 EP 200 DI 10.1001/archderm.128.2.193 PG 8 WC Dermatology SC Dermatology GA HC996 UT WOS:A1992HC99600004 PM 1739297 ER PT J AU SMITH, KJ SKELTON, HG YEAGER, J JAMES, WD WAGNER, KF AF SMITH, KJ SKELTON, HG YEAGER, J JAMES, WD WAGNER, KF TI MOLLUSCUM CONTAGIOSUM - ULTRASTRUCTURAL EVIDENCE FOR ITS PRESENCE IN SKIN ADJACENT TO CLINICAL LESIONS IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SO ARCHIVES OF DERMATOLOGY LA English DT Article AB Background and Design. -Molluscum contagiosum in acquired immunodeficiency disease, although not life threatening, is often a marker of late-stage disease and may lead to disfiguring cutaneous lesions. Although most current therapy results in at least temporary clearing of individual lesions, lesions frequently recur and new lesions arise. Examination of hematoxylin-eosin-stained histologic sections in two patients showed changes suggestive of viral infection in the epidermis 0.5 cm and 1 cm lateral to obvious clinical lesions. These areas were clinically free of any lesions. Both routine histopathologic examination and ultrastructural examination were performed in two patients infected with human immunodeficiency virus type 1 (HIV-1) and three non-HIV-1-infected patients. Results. -All patients showed histologic changes diagnostic of molluscum contagiosum. In addition, the sections from HIV-1-infected patients showed areas of acanthosis, hyperkeratosis, and nuclear atypia. Electron microscopy of these areas revealed rare viral organisms in these areas. Similar acanthotic, hyperkeratotic areas were not seen in the biopsy specimens from the non-HIV-1-infected patients and no viral particles were found in the epidermis around the lesions. Conclusion. -Viral structures consistent with molluscum contagiosum are present within the clinically normal epidermis around lesions of molluscum contagiosum in some HIV-1-infected patients. This may explain the large number of lesions seen in these patients and the difficulty in controlling the spread and recurrence of molluscum contagiosum in HIV-1-infected patients. C1 ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20306 USA. HENRY M JACKSON FDN, WASHINGTON, DC USA. WALTER REED ARMY MED CTR, DEPT DERMATOL, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20814 USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. FU NIAMS NIH HHS [AY01AR90008, NY01AR00014] NR 21 TC 35 Z9 36 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD FEB PY 1992 VL 128 IS 2 BP 223 EP 227 DI 10.1001/archderm.128.2.223 PG 5 WC Dermatology SC Dermatology GA HC996 UT WOS:A1992HC99600009 PM 1739301 ER PT J AU ZIESKE, LA AF ZIESKE, LA TI MYOFASCIAL FLAPS IN HEAD AND NECK RECONSTRUCTION SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material RP ZIESKE, LA (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD FEB PY 1992 VL 118 IS 2 BP 122 EP 122 PG 1 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA HC810 UT WOS:A1992HC81000002 ER PT J AU ZIESKE, LA AF ZIESKE, LA TI THE SYNERGISTIC EFFECTS OF RHODAMINE-123 AND MEROCYANINE-540 - SENSITIZATION OF HUMAN TUMOR-CELL LINES AFTER LASER EXPOSURE - A NEW TECHNIQUE OF PHOTODYNAMIC THERAPY SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material RP ZIESKE, LA (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD FEB PY 1992 VL 118 IS 2 BP 123 EP 123 PG 1 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA HC810 UT WOS:A1992HC81000005 ER PT J AU ADLER, M MOORE, DH FILBERT, MG AF ADLER, M MOORE, DH FILBERT, MG TI MECHANISM OF SOMAN-INDUCED CONTRACTIONS IN CANINE TRACHEAL SMOOTH-MUSCLE SO ARCHIVES OF TOXICOLOGY LA English DT Article DE TRACHEAL SMOOTH MUSCLE; CHOLINESTERASE INHIBITORS; MUSCARINIC RECEPTOR; SOMAN; ORGANOPHOSPHATE ID ACETYLCHOLINE; RECEPTORS; TISSUES; AIRWAY AB The actions of the irreversible organophosphorus cholinesterase (ChE) inhibitor soman were investigated on canine tracheal smooth muscle in vitro. Concentrations of soman greater-than-or-equal-to 1 nM increased the amplitude and decay of contractions elicited by electric field stimulation. The effect on decay showed a marked dependence on stimulation frequency, undergoing a 2.4-fold increase between 3 and 60 Hz. Soman also potentiated tensions due to bath applied acetylcholine (ACh). Little or no potentiation was observed for contractions elicited by carbamylcholine, an agonist that is not hydrolyzed by ChE. Concentration of soman greater-than-or-equal-to 3 nM led to the appearance of sustained contractures. These contractures developed with a delayed onset and were well correlated with ChE activity. Alkylation of muscarinic receptors by propylbenzilylcholine mustard antagonized the actions of soman on both spontaneous and electrically-evoked muscle contractions. The results are consistent with a mechanism in which the toxic actions of soman are mediated by accumulation of neurally-released ACh secondary to inhibition of ChE activity. An important factor in this accumulation is suggested to be the buffering effect of the muscarinic receptors on the efflux of ACh from the neuroeffector junction. RP ADLER, M (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 25 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-5761 J9 ARCH TOXICOL JI Arch. Toxicol. PD FEB PY 1992 VL 66 IS 3 BP 204 EP 210 DI 10.1007/BF01974016 PG 7 WC Toxicology SC Toxicology GA HE340 UT WOS:A1992HE34000009 PM 1497485 ER PT J AU THARION, WJ HOYT, RW MARLOWE, BE CYMERMAN, A AF THARION, WJ HOYT, RW MARLOWE, BE CYMERMAN, A TI EFFECTS OF HIGH-ALTITUDE AND EXERCISE ON MARKSMANSHIP SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID BETA-BLOCKADE; PERFORMANCE AB The effects of exercise and high altitude (3,700 m to 4,300 m) on marksmanship accuracy and sighting time were quantified in 16 experienced marksmen. Subjects dry-fired a disabled rifle equipped with a laser-based system from a free-standing position. The 2.3-cm circular target was at a distance of 5 m. Marksmanship was assessed under the following conditions: 1) at rest at sea level; 2) immediately after a 21-km run/walk ascent from 1,800 m to 4,300 m elevation; 3) at rest during days 1 to 3 at altitude; 4) at rest during days 14 to 16 at altitude; and 5) immediately after a second ascent after 17 d at altitude. Exercise reduced marksmanship accuracy (p < 0.05) but did not affect sighting time. Acute altitude exposure reduced marksmanship accuracy, and decreased sighting time (p < 0.05). However, after residence at altitude, accuracy and sighting time at rest returned to sea level values. Exercise and acute altitude exposure had similar but independent detrimental effects on marksmanship. C1 USA,ENVIRONM MED RES INST,DIV NEUROSCI & MIL PERFORMANCE,SGRP UE OP,NATICK,MA 01760. NR 13 TC 17 Z9 17 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 1992 VL 63 IS 2 BP 114 EP 117 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA HC248 UT WOS:A1992HC24800003 PM 1546938 ER PT J AU SHIPPEE, RL KOPPENHEFFER, T WATIWAT, SR BURLESON, DG MASON, AD AF SHIPPEE, RL KOPPENHEFFER, T WATIWAT, SR BURLESON, DG MASON, AD TI THE INTERACTION OF BURN INJURY AND ZINC NUTRITURE AS ASSESSED BY THE HUMORAL RESPONSE TO SHEEP RED-BLOOD-CELLS IN A BURN RAT MODEL SO BURNS LA English DT Article AB Clinical and animal studies suggest that burn injury induces alterations in zinc metabolism. It also has been established that zinc nutriture can cause alterations in the immune response, but there is a paucity of information concerning the interrelationship between burn injury, zinc nutriture and the immune response. In the present study, rats were subjected to full skin thickness dorsal scald injuries covering 30 per cent of the total body surface and then maintained on sufficient or deficient zinc intake. The rats were immunized with sheep red blood cells (SRBC) on day 6 postburn and killed 4 days later. The spleens were excised and spleen lymphocytes isolated and used in a Jerne plaque assay to determine the number of plaque-forming cells (PFC). The burn/zinc-sufficient regimen significantly increased (P < 0.01) the PFC response when compared to unburned zinc-sufficient or zinc-deficient control rats. Burned rats that were maintained on a zinc-deficient regimen showed a significant decrease (P < 0.05) in PFC when compared to burned rats maintained on a zinc-sufficient regimen. This study indicates an interaction of zinc in the primary humoral immune response following thermal injury. RP SHIPPEE, RL (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0305-4179 J9 BURNS JI Burns PD FEB PY 1992 VL 18 IS 1 BP 45 EP 48 DI 10.1016/0305-4179(92)90119-F PG 4 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA HA921 UT WOS:A1992HA92100010 PM 1558674 ER PT J AU FERRICK, MG WEYRICK, PB HUNNEWELL, ST AF FERRICK, MG WEYRICK, PB HUNNEWELL, ST TI ANALYSIS OF RIVER ICE MOTION NEAR A BREAKING FRONT SO CANADIAN JOURNAL OF CIVIL ENGINEERING LA English DT Article DE BREAKING FRONT; DYNAMIC ICE BREAKUP; ICE CONTINUITY; ICE CONVERGENCE; ICE MOTION; RIVER ICE AB Dynamic river ice breakup displays different behaviors depending on the physical characteristics of the river, the flow, and the ice cover. Although a quantitative theory of dynamic breakup is not yet available, one of the essential components of such a theory will be a description of the ice motion near the breaking front. In this paper we develop an analysis of this motion for a specific case. The analysis is generalized by allowing the speed of the breaking front to vary, and the parameters of the ice motion that are obtained represent different dynamic breakup behaviors that have been previously described. The results of the analysis include (i) the ice velocity, ice acceleration, and bank resistance at each point in a river reach as functions of time, (ii) the equilibrium ice velocity as a function of bank resistance and the ice velocity as a function of time for several initial and bank resistance conditions, and (iii) the time of ice motion, ice velocity, ice acceleration, and the convergence of the moving ice with distance from the breaking front. The measure of ice convergence quantifies the loss of surface area by the sheet required for ice continuity, and distinguishes the basic types of dynamic breakup. RP FERRICK, MG (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 9 TC 10 Z9 10 U1 0 U2 0 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0315-1468 J9 CAN J CIVIL ENG JI Can. J. Civ. Eng. PD FEB PY 1992 VL 19 IS 1 BP 105 EP 116 PG 12 WC Engineering, Civil SC Engineering GA HR559 UT WOS:A1992HR55900011 ER PT J AU BECKETT, DC AARTILA, TP MILLER, AC AF BECKETT, DC AARTILA, TP MILLER, AC TI INVERTEBRATE ABUNDANCE ON POTAMOGETON-NODOSUS - EFFECTS OF PLANT-SURFACE AREA AND CONDITION SO CANADIAN JOURNAL OF ZOOLOGY-REVUE CANADIENNE DE ZOOLOGIE LA English DT Article ID EPIPHYTIC MACROINVERTEBRATES; SUBMERSED MACROPHYTES; FLORIDA LAKES AB Using the macrophyte Potamogeton nodosus, we investigated variability in abundance of plant-dwelling invertebrates among individual plants. Plants were collected from three Potamogeton beds in Eau Galle Lake, Wisconsin, in June and August 1987. Invertebrate abundance on P. nodosus and the amount of plant surface area were positively correlated in both June and August. In August the amount of leaf damage (plant condition) was another important predictor of invertebrate abundance. Plant surface area and plant condition were responsible for most to almost all of the variability in invertebrate abundance on P. nodosus (R2 = 0.66 in June; R2 = 0.83 in August). The correlation between invertebrate abundance and plant condition in August and the lack of such a correlation in June indicated that plant age, rather than plant condition per se, was a causal mechanism for increased invertebrate abundance. Some plants were heavily colonized by invertebrates: a single plant collected in June held a total of 555 invertebrates, which included 177 chironomid larvae and 143 naidid worms. We estimate that the P. nodosus in a 20 x 60 m Potamogeton bed supported about 33 million invertebrates in June and approximately 30 million invertebrates in August. The use of take management techniques in which plants are eliminated would therefore markedly reduce invertebrate abundance in the littoral zone, and would, in turn, deny fishes and waterfowl an important and abundant food resource. C1 USA,ENVIRONM LAB,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP BECKETT, DC (reprint author), UNIV SO MISSISSIPPI,DEPT BIOL SCI,HATTIESBURG,MS 39406, USA. NR 32 TC 26 Z9 26 U1 0 U2 3 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4301 J9 CAN J ZOOL JI Can. J. Zool.-Rev. Can. Zool. PD FEB PY 1992 VL 70 IS 2 BP 300 EP 306 DI 10.1139/z92-045 PG 7 WC Zoology SC Zoology GA HR073 UT WOS:A1992HR07300015 ER PT J AU ROACH, JM RIPPLE, G DILLARD, TA AF ROACH, JM RIPPLE, G DILLARD, TA TI INADVERTENT LOSS OF BRONCHOSCOPY INSTRUMENTS IN THE TRACHEOBRONCHIAL TREE SO CHEST LA English DT Article ID FLEXIBLE FIBEROPTIC BRONCHOSCOPY; FOREIGN-BODIES; COMPLICATIONS; BREAKAGE; ADULTS AB Equipment malfunction is a rare complication of flexible fiberoptic bronchoscopy. We report an unusual example of equipment failure resulting in the inadvertent introduction of a foreign body (the tip of a cleaning brush) into the bronchial tree of a patient during FFB. In addition, we review several other cases in which problems have been caused by malfunction of accessory equipment. Careful inspection of all cleaning and biopsy utensils should reduce the chance of istrogenically introducing a foreign body from the bronchoscope channel into the patient's airway. We suggest that biopsy forceps are the best retrieval instrument to use when the foreign body involved is a brush or a piece of wire. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP ROACH, JM (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 20 TC 3 Z9 4 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD FEB PY 1992 VL 101 IS 2 BP 568 EP 569 DI 10.1378/chest.101.2.568 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA HC557 UT WOS:A1992HC55700060 PM 1735295 ER PT J AU ZEIGLER, D BENJAMIN, J CRAIG, BE LI, SH SHOAF, SE MAX, MB AF ZEIGLER, D BENJAMIN, J CRAIG, BE LI, SH SHOAF, SE MAX, MB TI SINGLE DOSES OF DESIPRAMINE DO NOT POTENTIATE POSTOPERATIVE MORPHINE ANALGESIA SO CLINICAL PHARMACOLOGY & THERAPEUTICS LA English DT Meeting Abstract C1 NIDR,NEUROBIOL & ANESTHESIA BRANCH,BETHESDA,MD 20892. NIAAA,CLIN STUDIES LAB,BETHESDA,MD. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0009-9236 J9 CLIN PHARMACOL THER JI Clin. Pharmacol. Ther. PD FEB PY 1992 VL 51 IS 2 BP 146 EP 146 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA HE703 UT WOS:A1992HE70300102 ER PT J AU HARRIS, LW GENNINGS, C CARTER, WH ANDERSON, DR BOWERSOX, SL SOLANA, RP AF HARRIS, LW GENNINGS, C CARTER, WH ANDERSON, DR BOWERSOX, SL SOLANA, RP TI EFFICACY COMPARISON OF SCOPOLAMINE (SCP) AND DIAZEPAM (DZ) IN SOMAN EXPOSED GUINEA-PIGS SO CLINICAL PHARMACOLOGY & THERAPEUTICS LA English DT Meeting Abstract C1 USA,MRICD,ABERDEEN PROVING GROUND,MD 21010. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,RICHMOND,VA 23298. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0009-9236 J9 CLIN PHARMACOL THER JI Clin. Pharmacol. Ther. PD FEB PY 1992 VL 51 IS 2 BP 159 EP 159 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA HE703 UT WOS:A1992HE70300152 ER PT J AU AYAU, EL UYEHARA, CFT EISENHAUER, CL LEWIS, DE NAKAMURA, KT AF AYAU, EL UYEHARA, CFT EISENHAUER, CL LEWIS, DE NAKAMURA, KT TI METHAMPHETAMINE RECOVERY FROM MECONIUM AND AMNIOTIC-FLUID IN GUINEA-PIGS DEPENDS ON GESTATIONAL-AGE AND METABOLISM SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,HONOLULU,HI 96822. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. US DRUG TESTING LABS,CHICAGO,IL. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1992 VL 40 IS 1 BP A65 EP A65 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HA103 UT WOS:A1992HA10300353 ER PT J AU EASA, D MUNDIE, TG UYEHARA, CFT FINN, K BALARAMAN, V TAKENAKA, W AF EASA, D MUNDIE, TG UYEHARA, CFT FINN, K BALARAMAN, V TAKENAKA, W TI PULMONARY-FUNCTION AND HEMODYNAMIC-EFFECTS OF CONTINUOUS NEGATIVE EXTRATHORACIC PRESSURE (CNEP) IN VENTILATED PIGLETS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. UNIV HAWAII,JOHN A BURNS SCH MED,DEPT PEDIAT,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1992 VL 40 IS 1 BP A83 EP A83 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HA103 UT WOS:A1992HA10300458 ER PT J AU MUNDIE, TG EASA, D FINN, K STEVENS, EL HASHIRO, GM UYEHARA, CFT AF MUNDIE, TG EASA, D FINN, K STEVENS, EL HASHIRO, GM UYEHARA, CFT TI EFFECTS OF 2 HOURS OF CONTINUOUS NEGATIVE EXTRATHORACIC PRESSURE (CNEP) ON PULMONARY-FUNCTION AND HEMODYNAMICS IN VENTILATED PIGLETS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. UNIV HAWAII,JOHN A BURNS SCH MED,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1992 VL 40 IS 1 BP A84 EP A84 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HA103 UT WOS:A1992HA10300466 ER PT J AU UYEHARA, CFT MATSUDA, LS CLAYBAUGH, JR AF UYEHARA, CFT MATSUDA, LS CLAYBAUGH, JR TI VASOPRESSIN EFFECTS ON PULMONARY VASCULAR-RESISTANCE AND ARTERIAL BLOOD-GASES IN NEONATAL PIGLETS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. KAPIOLANI MED CTR,HONOLULU,HI. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1992 VL 40 IS 1 BP A91 EP A91 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HA103 UT WOS:A1992HA10300505 ER PT J AU UYEHARA, CFT DESILVA, AS BERKENBAUGH, JT NAKAMURA, KT AF UYEHARA, CFT DESILVA, AS BERKENBAUGH, JT NAKAMURA, KT TI ONTOGENY OF AORTIC CONTRACTILITY TO CIRCULATING HORMONES IN HYPERTENSIVE AND NORMOTENSIVE RATS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,HONOLULU,HI 96822. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1992 VL 40 IS 1 BP A21 EP A21 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HA103 UT WOS:A1992HA10300113 ER PT J AU TUCKER, WB PEROVICH, DK AF TUCKER, WB PEROVICH, DK TI STRESS MEASUREMENTS IN DRIFTING PACK ICE SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article ID SEA ICE; NOISE AB Accurate measurements of in-situ pack ice forces are necessary to improve ice forecasting models and to estimate loads on offshore structures. Two months of in-situ ice stress measurements were obtained in the pack ice of the eastern Arctic during the fall of 1988. Sensors were placed to examine both the horizontal and vertical distributions of ice stresses in multiyear ice. Stresses in the multiyear ice 200 m from the edge of the floe reached 150 kPa during extreme deformation events. Within a few meters of the edge and in adjacent first-year ice, they exceeded 350 kPa on several occasions (400 kPa in one instance) during local ice failure events. Thermally induced stresses at shallow depths in the multiyear ice were caused by rapid temperature changes and could be nearly as large as stresses observed during deformation. The vertical distribution of stresses varied with the type of deformation event, but the largest values were always observed in the upper half of the ice sheet. Stresses due to deformation were rapidly attenuated away from the edge of the floe. Near the edge, however, recorded stresses agreed well with those observed in the adjacent first-year ice. These two locations also experienced twice daily oscillations of about 50 kPa which are apparently tidal or inertially induced. RP TUCKER, WB (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 28 TC 23 Z9 24 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD FEB PY 1992 VL 20 IS 2 BP 119 EP 139 DI 10.1016/0165-232X(92)90012-J PG 21 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA HH335 UT WOS:A1992HH33500002 ER PT J AU LESKOVAC, V PEGGINS, JO AF LESKOVAC, V PEGGINS, JO TI HEPATIC-METABOLISM OF ARTEMISININ DRUGS .3. INDUCTION OF HYDROGEN-PEROXIDE PRODUCTION IN RAT-LIVER MICROSOMES BY ARTEMISININ DRUGS SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY LA English DT Article ID MONO-OXYGENASE SYSTEM; SUPEROXIDE ANION; OXIDASE AB 1. In this communication, induction of hydrogen peroxide production by the semisynthetic antimalarial drugs of the artemisinin class (beta-arteether, beta-artelinic acid and dihydroartemisinin) in rat liver microsomes, is reported. 2. Endogenous, NADPH-dependent, production of hydrogen peroxide in rat liver microsomes was enhanced in the presence of arteether and artelinic acid, but not in the presence of dihydroartemisinin. 3. NADPH-dependent metabolism of arteether and artelinic acid was closely coupled to the drug-induced production of hydrogen peroxide. 4. The redox cycle of cytochrome P-450 was presented, which describes satisfactorily both the endogenous and the drug-assisted hydrogen peroxide production in rat liver microsomes; also, the rate-limiting step of the cycle was identified. C1 WALTER REED ARMY MED CTR, DIV EXPTL THERAPEUT, WASHINGTON, DC 20307 USA. NR 21 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1532-0456 EI 1878-1659 J9 COMP BIOCHEM PHYS C JI Comp. Biochem. Physiol. C-Toxicol. Pharmacol. PD FEB PY 1992 VL 101 IS 2 BP 203 EP 208 DI 10.1016/0742-8413(92)90261-5 PG 6 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology GA HM516 UT WOS:A1992HM51600003 PM 1354091 ER PT J AU TEZDUYAR, TE BEHR, M LIOU, J AF TEZDUYAR, TE BEHR, M LIOU, J TI A NEW STRATEGY FOR FINITE-ELEMENT COMPUTATIONS INVOLVING MOVING BOUNDARIES AND INTERFACES - THE DEFORMING-SPATIAL-DOMAIN SPACE-TIME PROCEDURE .1. THE CONCEPT AND THE PRELIMINARY NUMERICAL TESTS SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article ID FLUID-DYNAMICS; FORMULATION; EQUATIONS AB A new strategy based on the stabilized space-time finite element formulation is proposed for computations involving moving boundaries and interfaces. In the deforming-spatial-domain/space-time (DSD/ST) procedure the variational formulation of a problem is written over its space-time domain, and therefore the deformation of the spatial domain with respect to time is taken into account automatically. Because the space-time mesh is generated over the space-time domain of the problem, within each time step, the boundary (or interface) nodes move with the boundary (or interface). Whether the motion of the boundary is specified or not, the strategy is nearly the same. If the motion of the boundary is unknown, then the boundary nodes move as defined by the other unknowns at the boundary (such as the velocity or the displacement). At the end of each time step a new spatial mesh covers the new spatial domain. For computational feasibility, the finite element interpolation functions are chosen to be discontinuous in time, and the fully discretized equations are solved one space-time slab at a time. C1 AMOCO PROD CO,TULSA RES CTR,TULSA,OK 74102. UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55415. RP TEZDUYAR, TE (reprint author), UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,DEPT AEROSP ENGN & MECH,1200 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. RI Behr, Marek/H-5401-2011; Tezduyar, Tayfun/F-6134-2012 OI Behr, Marek/0000-0003-4257-8276; Tezduyar, Tayfun/0000-0001-8707-3162 NR 12 TC 467 Z9 483 U1 4 U2 21 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0045-7825 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD FEB PY 1992 VL 94 IS 3 BP 339 EP 351 DI 10.1016/0045-7825(92)90059-S PG 13 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA HJ361 UT WOS:A1992HJ36100003 ER PT J AU TEZDUYAR, TE BEHR, M MITTAL, S LIOU, J AF TEZDUYAR, TE BEHR, M MITTAL, S LIOU, J TI A NEW STRATEGY FOR FINITE-ELEMENT COMPUTATIONS INVOLVING MOVING BOUNDARIES AND INTERFACES - THE DEFORMING-SPATIAL-DOMAIN SPACE-TIME PROCEDURE .2. COMPUTATION OF FREE-SURFACE FLOWS, 2-LIQUID FLOWS, AND FLOWS WITH DRIFTING CYLINDERS SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article ID FLUID-DYNAMICS; FORMULATION; EQUATIONS AB New finite element computational strategies for free-surface flows, two-liquid flows, and flows with drifting cylinders are presented. These strategies are based on the deforming spatial-domain/space-time (DSD/ST) procedure. In the DSD/ST approach, the stabilized variational formulations for these types of flow problem are written over their space-time domains. One of the important features of the approach is that it enables one to circumvent the difficulty involved in remeshing every time step and thus reduces the projection errors introduced by such frequent remeshings. Computations are performed for various test problems mainly for the purpose of demonstrating the computational capability developed for this class of problems. In some of the test cases, such as the liquid drop problem, surface tension is taken into account. For flows involving drifting cylinders, the mesh moving and remeshing schemes proposed are convenient and reduce the frequency of remeshing. C1 UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55415. AMOCO PROD CO,TULSA RES CTR,TULSA,OK 74102. RP TEZDUYAR, TE (reprint author), UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,DEPT AEROSP ENGN & MECH,1200 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. RI Behr, Marek/H-5401-2011; Tezduyar, Tayfun/F-6134-2012 OI Behr, Marek/0000-0003-4257-8276; Tezduyar, Tayfun/0000-0001-8707-3162 NR 10 TC 358 Z9 365 U1 1 U2 14 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0045-7825 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD FEB PY 1992 VL 94 IS 3 BP 353 EP 371 DI 10.1016/0045-7825(92)90060-W PG 19 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA HJ361 UT WOS:A1992HJ36100004 ER PT J AU SMALLRIDGE, RC AF SMALLRIDGE, RC TI METABOLIC AND ANATOMIC THYROID EMERGENCIES - A REVIEW SO CRITICAL CARE MEDICINE LA English DT Review DE THYROID DISEASES; CRITICAL CARE; THYROID STORM; GOITER, SUBSTERNAL; HYPERTHYROIDISM; LYMPHOMA; THYROTROPIN; HEMODYNAMICS; THYROTOXICOSIS; BETA-ADRENERGIC RECEPTOR BLOCKERS; AIRWAY OBSTRUCTION ID SUPERIOR VENA-CAVA; IMPAIRED WATER-EXCRETION; OBSTRUCTIVE SLEEP-APNEA; INTRA-THORACIC GOITER; COMPLETE HEART-BLOCK; LONG-TERM TREATMENT; GRAVES-DISEASE; HYPOTHYROID PATIENTS; PITUITARY-TUMOR; HYPO-THYROIDISM AB Purpose: To review the diagnosis and management of thyroid diseases, both metabolic (thyroid storm and myxedema coma) and anatomic (substernal goiter, lymphoma, anaplastic carcinoma) that may require intensive care therapy. Data Sources: English-language articles were identified through a search of the MEDLINE and Index Medicus databases. Bibliographies of retrieved articles were examined for relevant articles. Study Selection: Approximately 250 articles were reviewed. Those articles deemed most representative were utilized. Case reports were included to highlight rare, but potentially lethal complications. Data Extraction: All data were analyzed by one observer. Limitations of the data are discussed. Data Synthesis: Guidelines for determining the etiology of thyrotoxic crisis are outlined. Criteria for distinguishing critically ill hypothyroid patients from those patients with the euthyroid sick syndrome are given. Therapy for both disorders must be aggressive and multifaceted, and detailed management is indicated. Substernal goiter is almost always benign, but may cause various acute complications, including dyspnea, respiratory failure, superior vena caval syndrome, esophageal varices (downhill), and others. Surgery almost always corrects the problem. Lymphomas present with rapid thyroid enlargement. Recent studies suggest that surgery may assume more of a supportive role, used principally to obtain adequate tissue for histologic classification. Conclusions: Thyroid disorders can produce emergencies requiring the attention of multiple medical and surgical specialists. While management is often successful, future studies should address the following three areas: a) optimization of thyroid hormone dose for treatment of myxedema coma; b) clarification of the role of radiotherapy and/or chemotherapy for thyroid lymphoma; and c) more effective therapy for anaplastic carcinoma. RP SMALLRIDGE, RC (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307, USA. NR 154 TC 28 Z9 29 U1 1 U2 4 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD FEB PY 1992 VL 20 IS 2 BP 276 EP 291 DI 10.1097/00003246-199202000-00016 PG 16 WC Critical Care Medicine SC General & Internal Medicine GA HC983 UT WOS:A1992HC98300016 PM 1737461 ER PT J AU EHLEN, J AF EHLEN, J TI ANALYSIS OF SPATIAL RELATIONSHIPS AMONG GEOMORPHIC, PETROGRAPHIC AND STRUCTURAL CHARACTERISTICS OF THE DARTMOOR TORS SO EARTH SURFACE PROCESSES AND LANDFORMS LA English DT Article DE LANDFORM CLASSIFICATION; TORS; DARTMOOR; ROCK COMPOSITION; ROCK GRAIN SIZE; JOINTS; ROCK TEXTURE ID BORNHARDTS AB The granite tors of Dartmoor are characterized by using the regional spatial patterns of 21 geomorphic, petrographic, and structural variables. The data were derived from topographic maps, field measurement, and laboratory analysis of rock samples collected in the field. Identification of spatial patterns and comparison of patterns between variables were made on contour maps generated from the data using ARC/INFO. Three tor types-summit tors, valleyside tors, and spur tors-are semiquantitatively characterized using these data and procedures. The three types of tors are distinguished with respect to variations in relative relief, joint spacing and joint type, rock texture, grain size, and composition. Summit tors have the highest relative relief (mean: 125.7 m), contain the most potassium feldspar (> 30 per cent), and have the most widely-spaced primary vertical (> 300 cm) and secondary horizontal joints (> 10 cm). The rocks are the most megacrystic (> 15 per cent) and the coarsest grained. Plagioclase is also abundant in summit tors. Valleyside tors have the lowest relative relief (mean: 72.9 m) and the most widely-spaced horizontal joints (primary, 60-200 cm; secondary, > 10 cm). Grain size, vertical joint spacing, and quartz and potassium feldspar abundances are intermediate. The shapes of valleyside tors are controlled by horizontal joints and the rocks are either very feebly magcrystic or equigranular in texture. Spur tors have intermediate relative relief (mean: 115.4 m), the narrowest joint spacing (vertical joints, < 200 cm, 50-75 cm; horizontal joints < 60 cm, < 10 cm) and the finest grain. In addition, the rocks are feebly magacrystic. RP EHLEN, J (reprint author), USA,ENGINEER TOPOG LABS,RES INST,DIV REMOTE SENSING,FT BELVOIR,VA 22060, USA. NR 33 TC 8 Z9 8 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0197-9337 J9 EARTH SURF PROCESSES JI Earth Surf. Process. Landf. PD FEB PY 1992 VL 17 IS 1 BP 53 EP 67 DI 10.1002/esp.3290170105 PG 15 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA HA460 UT WOS:A1992HA46000004 ER PT J AU DAVIES, FG KILELU, E LINTHICUM, KJ PEGRAM, RG AF DAVIES, FG KILELU, E LINTHICUM, KJ PEGRAM, RG TI PATTERNS OF RIFT-VALLEY FEVER ACTIVITY IN ZAMBIA SO EPIDEMIOLOGY AND INFECTION LA English DT Article ID KENYA; VIRUS AB An hypothesis that there was an annual emergence of Rift Valley fever virus in Zambia, during or after the seasonal rains, was examined with the aid of sentinel cattle. Serum samples taken during 1974 and 1978 showed evidence of epizootic Rift Valley fever in Zambia, with more than 80% positive. A sentinel herd exposed from 1982 to 1986 showed that some Rift Valley fever occurred each year. This was usually at a low level, with 3-8% of the susceptible cattle seroconverting. In 1985-6 more than 20% of the animals seroconverted. and this greater activity was associated with vegetational changes - which could be detected by remote-sensing satellite imagery which have also been associated with greater virus activity in Kenya. C1 FAO,DANIDA TICK CONTROL PROJECT,DEPT VET & TSETSE CONTROL SERV,BALMORAL,ZAMBIA. VET RES LAB,KABETE,KENYA. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP DAVIES, FG (reprint author), WHO,FAO,REG REFERENCE CTR RIFT VALLEY FEVER,KABETE,KENYA. NR 15 TC 21 Z9 25 U1 0 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD FEB PY 1992 VL 108 IS 1 BP 185 EP 191 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA HK032 UT WOS:A1992HK03200019 PM 1547835 ER PT J AU MILLET, P CHIZZOLINI, C WIRTZ, RA BATHURST, I BRODERSON, JR CAMPBELL, GH COLLINS, WE AF MILLET, P CHIZZOLINI, C WIRTZ, RA BATHURST, I BRODERSON, JR CAMPBELL, GH COLLINS, WE TI INHIBITORY ACTIVITY AGAINST SPOROZOITES INDUCED BY ANTIBODIES DIRECTED AGAINST NONREPETITIVE REGIONS OF THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-VIVAX SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article ID SYNTHETIC PEPTIDES; ANTIGENIC ANALYSIS; REPEAT DOMAIN; FALCIPARUM; IMMUNOGENICITY; EPITOPES; KNOWLESI; INVITRO; MICE AB In previous studies, Saimiri sciureus boliviensis monkeys have been immunized with four recombinant proteins reproducing part of the circumsporozoite (CS) protein of Plasmodium vivax sporozoites (NS1(81)V20, rPvCS-1, rPvCS-2, rPvCS-3), or with irradiated sporozoites of P. vivax Salvador I strain. To analyze the antibody response elicited against epitopes located outside the immunodominant repeat region of the CS protein, serum samples from these animals were tested for their ability to inhibit the in vitro development of liver stages of P. vivax VK247 strain, characterized from the other strains only by a specific repeat region on the CS protein. Results indicated that there is at least one protective B-cell epitope outside the repeat region of the CS protein of P. vivax sporozoites, and that this epitope can be expressed by irradiated sporozoites, rPvCS-2 and -3, but not by rPvCS-1 or NS1(81)V20. Therefore, we designed peptides from the amino acid sequences present both in rPvCS-2 and -3, but not included in the recombinant proteins rPvCS-1 and NS1(81)V20. Anti-peptide antibodies had no activity on the development of sporozoites of P. vivax Salvador I strain, into schizonts in primary culture of Saimiri monkey hepatocytes. In addition, antisporozoite antibodies did not react with any of the peptides. These results suggest that the in vitro inhibition observed in this study could depend upon the conformation of the CS protein. This study also demonstrates that antibody response to unnatural linear epitopes can be induced by immunization with recombinant proteins. C1 CHIRON CORP,EMERYVILLE,CA. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. CTR DIS CONTROL,CTR PATHOL 2,SCI RESOURCES PROGRAM,ATLANTA,GA 30333. RP MILLET, P (reprint author), CTR DIS CONTROL,CTR PATHOL 2,DIV PARASIT DIS F12,MALARIA BRANCH,ATLANTA,GA 30333, USA. NR 23 TC 9 Z9 9 U1 0 U2 1 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD FEB PY 1992 VL 22 IS 2 BP 519 EP 524 DI 10.1002/eji.1830220234 PG 6 WC Immunology SC Immunology GA HF952 UT WOS:A1992HF95200033 PM 1371470 ER PT J AU GUERTLER, AT LAGUTCHIK, MS MARTIN, DG AF GUERTLER, AT LAGUTCHIK, MS MARTIN, DG TI TOPICAL ANESTHETIC-INDUCED METHEMOGLOBINEMIA IN SHEEP - A COMPARISON OF BENZOCAINE AND LIDOCAINE SO FUNDAMENTAL AND APPLIED TOXICOLOGY LA English DT Article ID GLUCOSE-6-PHOSPHATE-DEHYDROGENASE G-6-PD ACTIVITY; CETACAINE; SUSCEPTIBILITY; DEFICIENCY C1 WALTER REED ARMY MED CTR,DIV MED,DEPT RESP RES,WASHINGTON,DC 20307. RP GUERTLER, AT (reprint author), WALTER REED ARMY MED CTR,MED RES FELLOWSHIP,WASHINGTON,DC 20307, USA. NR 37 TC 14 Z9 14 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0272-0590 J9 FUND APPL TOXICOL JI Fundam. Appl. Toxicol. PD FEB PY 1992 VL 18 IS 2 BP 294 EP 298 DI 10.1016/0272-0590(92)90058-P PG 5 WC Toxicology SC Toxicology GA HD260 UT WOS:A1992HD26000017 PM 1601230 ER PT J AU MIZAN, M MCGOWAN, R AF MIZAN, M MCGOWAN, R TI RESIDUAL PHASE NOISE PERFORMANCE OF X-BAND GAAS-FET AMPLIFIERS AT LIQUID-NITROGEN TEMPERATURE SO IEE PROCEEDINGS-G CIRCUITS DEVICES AND SYSTEMS LA English DT Article DE AMPLIFIERS; NOISE AND INTERFERENCE AB High-performance X-band GaAs FET amplifiers were evaluated at room temperature and 77 K, to determine the residual phase noise of the amplifiers. The data revealed 15-50 dBc/Hz degradation in the close-in residual phase noise when the amplifiers were operated at 77 K. RP MIZAN, M (reprint author), USA,COMMAND LAB,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD, ENGLAND SG1 2AY SN 0956-3768 J9 IEE PROC-G PD FEB PY 1992 VL 139 IS 1 BP 37 EP 38 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA HD515 UT WOS:A1992HD51500008 ER PT J AU TUMOLILLO, TA ASHLEY, PR AF TUMOLILLO, TA ASHLEY, PR TI A NOVEL PULSE-POLING TECHNIQUE FOR EO POLYMER WAVE-GUIDE DEVICES USING DEVICE ELECTRODE POLING SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article AB Described here is a novel method for poling electrooptic polymer modulators using a pulse-poling technique. Device electrodes were used directly for poling, such that the poling field is selectively applied in a counter-aligned fashion while the signal field is coaligned, thus requiring only a single-voltage source for poling and modulation. Channel waveguide losses caused by poling with the device electrodes were measured and compared to total waveguide poling. The technique was found to introduce less overall loss for devices with inactive waveguide regions of more than a few millimeters and simplifies fabrication requirements. RP TUMOLILLO, TA (reprint author), USA,MISSILE COMMAND,CTR DEV & ENGN CTR,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 9 TC 25 Z9 25 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD FEB PY 1992 VL 4 IS 2 BP 142 EP 145 DI 10.1109/68.122342 PG 4 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA HD298 UT WOS:A1992HD29800011 ER PT J AU AZIMISADJADI, MR POOLE, DE SHEEDVASH, S SHERBONDY, KD STRICKER, SA AF AZIMISADJADI, MR POOLE, DE SHEEDVASH, S SHERBONDY, KD STRICKER, SA TI DETECTION AND CLASSIFICATION OF BURIED DIELECTRIC ANOMALIES USING A SEPARATED APERTURE SENSOR AND A NEURAL NETWORK DISCRIMINATOR SO IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT LA English DT Article; Proceedings Paper CT 8TH ANNUAL CONF ON THE INSTRUMENTATION AND MEASUREMENT TECHNOLOGY ( IMTC/91 ) CY MAY 14-16, 1991 CL ATLANTA, GA SP IEEE, INSTRUMENTAT MEASUREMENT SOC, IEEE, ATLANTA SECTION AB The problem of detection and classification of buried dielectric anomalies using a separated aperture microwave sensor and an artificial neural network discriminator was considered. Several methods for training and data representation were developed to study the trainability and generalization capabilities of the networks. The effect of the architectural variation on the network performance was also studied. The principal component method was used to reduce the volume of the data and also the dimension of the weight space. Simulation results on two types of targets were obtained which indicated superior detection and classification performance when compared with the conventional methods. C1 USA,BELVOIR RD&E CTR,COUNTERMINE SYST DIRECTORATE,FT BELVOIR,VA 22060. RP AZIMISADJADI, MR (reprint author), COLORADO STATE UNIV,DEPT ELECT ENGN,FT COLLINS,CO 80523, USA. OI Sherbondy, Kelly/0000-0003-4730-3706 NR 15 TC 15 Z9 15 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9456 J9 IEEE T INSTRUM MEAS JI IEEE Trans. Instrum. Meas. PD FEB PY 1992 VL 41 IS 1 BP 137 EP 143 DI 10.1109/19.126648 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA HK154 UT WOS:A1992HK15400029 ER PT J AU LIESKE, CN KLOPCIC, RS GROSS, CL CLARK, JH DOLZINE, TW LOGAN, TP MEYER, HG AF LIESKE, CN KLOPCIC, RS GROSS, CL CLARK, JH DOLZINE, TW LOGAN, TP MEYER, HG TI DEVELOPMENT OF AN ANTIBODY THAT BINDS SULFUR MUSTARD SO IMMUNOLOGY LETTERS LA English DT Article DE SULFUR MUSTARD; SULFUR MUSTARD ANTIBODY; ANTIBODY INHIBITION; HAPTENS AB An antibody that binds bis(2-chloroethyl)sulfide (sulfur mustard) was developed. The immunizing antigen was prepared from the hapten 4-(2-chloroethyl)benzoic acid covalently bound to keyhole limpet hemocyanin (KLH). The antibody was monitored by a solid phase enzyme-linked immunosorbent assay (ELISA). The test antigen consisted of a second hapten, 8-chlorocaprylic acid, covalently bound to bovine serum albumin (BSA). The test antigen was absorbed to the wells of 96-well plates. The immunizing and test antigens contain a common chloroethyl moiety. Thiodiglycol, the principal hydrolysis product of sulfur mustard, does not react with the antibody. This antibody, because of its specificity, has the potential to be a valuable tool for mustard research and forensic detection. RP LIESKE, CN (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 19 TC 8 Z9 8 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2478 J9 IMMUNOL LETT JI Immunol. Lett. PD FEB 1 PY 1992 VL 31 IS 2 BP 117 EP 122 DI 10.1016/0165-2478(92)90137-D PG 6 WC Immunology SC Immunology GA GY339 UT WOS:A1992GY33900004 PM 1740349 ER PT J AU LENZ, DE YOURICK, JJ DAWSON, JS SCOTT, J AF LENZ, DE YOURICK, JJ DAWSON, JS SCOTT, J TI MONOCLONAL-ANTIBODIES AGAINST SOMAN - CHARACTERIZATION OF SOMAN STEREOISOMERS SO IMMUNOLOGY LETTERS LA English DT Article DE SOMAN; ANTIBODIES; STEREOISOMERS; ABSOLUTE CONFIGURATION ID NERVE AGENT SOMAN; PHOSPHORUS AB Hybridomas were produced which expressed monoclonal anti-soman antibodies as determined by microtiter enzyme-linked-antibody immunoassay (EIA). Each of these antibodies was titrated using a competitive inhibition enzyme immunoassay (CIEIA) with a variety of test ligands. The ligands used included soman (a racemic mixture), sarin, tabun, and each of the four stereoisomers of soman (C+P+, C+P-, C-P+ and C-P-). In all cases the antibodies tested exhibited IC50 values of 10(-4)-5 x 10(-6) M for soman. When sarin or tabun was used as a ligand, the antibodies exhibited no cross reactivity. All of the antibodies cross reacted with the four soman stereoisomers. A second group of hybridomas were produced which expressed monoclonal antibodies against C(S)P(S)-soman. These antibodies were used to make preliminary absolute chiral assignments to the four soman stereoisomers. RP LENZ, DE (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 7 TC 14 Z9 14 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2478 J9 IMMUNOL LETT JI Immunol. Lett. PD FEB 1 PY 1992 VL 31 IS 2 BP 131 EP 135 DI 10.1016/0165-2478(92)90139-F PG 5 WC Immunology SC Immunology GA GY339 UT WOS:A1992GY33900006 PM 1740351 ER PT J AU OAKS, EV TURBYFILL, KR AF OAKS, EV TURBYFILL, KR TI MYOSIN-CROSS-REACTIVE EPITOPE OF SHIGELLA-FLEXNERI INVASION PLASMID ANTIGEN-B SO INFECTION AND IMMUNITY LA English DT Article ID STREPTOCOCCAL M-PROTEIN; MONOCLONAL-ANTIBODIES; NUCLEOTIDE-SEQUENCE; SECONDARY-STRUCTURE; MOLECULAR-CLONING; HELA-CELLS; AMINO-ACID; GENE; SPREAD; LOCUS AB IpaB, invasion plasmid antigen B, of Shigella flexneri is a 62-kDa protein required for invasion of intestinal epithelial cells. IpaB is also one of several major protein antigens recognized by the humoral immune systems of most humans and monkeys after infection with shigellae. Computer analysis of the deduced IpaB amino acid sequence indicates that an alpha-helical structure is likely through much of the molecule. Homology searches with protein data banks show that one alpha-helical domain between amino acid residues 95 and 181 has a moderate level of identity with myosin and streptococcal M protein. By using a monoclonal antibody (2F1) which recognizes an epitope in the amino-terminal third of the IpaB protein, it was possible to demonstrate a cross-reactive epitope(s) on skeletal muscle myosin. Epitope mapping localized the 2F1 epitope to three noncontiguous regions of the IpaB protein within the alpha-helical domain that contains homology with myosin. Antibodies produced in rabbits immunized with synthetic peptides from one of the 2F1 epitope regions (residues 99 to 110) of IpaB were capable of reacting with IpaB as well as myosin. Furthermore, sera from several monkeys previously infected with S. flexneri 2a contained antibodies to IpaB pep 101-116 (IpaB peptide 101-116) and also myosin. Sera from animals with antibodies against other IpaB peptides did not contain antibodies against myosin. RP OAKS, EV (reprint author), WALTER REED ARMY MED CTR,DEPT ENTER INFECT,WASHINGTON,DC 20307, USA. NR 39 TC 5 Z9 5 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD FEB PY 1992 VL 60 IS 2 BP 557 EP 564 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA HA564 UT WOS:A1992HA56400034 PM 1370431 ER PT J AU IVINS, BE WELKOS, SL LITTLE, SF CRUMRINE, MH NELSON, GO AF IVINS, BE WELKOS, SL LITTLE, SF CRUMRINE, MH NELSON, GO TI IMMUNIZATION AGAINST ANTHRAX WITH BACILLUS-ANTHRACIS PROTECTIVE ANTIGEN COMBINED WITH ADJUVANTS SO INFECTION AND IMMUNITY LA English DT Article ID STERNE STRAIN; GUINEA-PIGS; RESISTANCE; IMMUNITY; TOXIN; MICE; EXPRESSION; ANTIBODIES; RELEVANCE; SUBTILIS AB The protective efficacy of immunization against anthrax with Bacillus anthracis protective antigen (PA) combined with different adjuvants was tested in Hartley guinea pigs and CBA/J and A/J mice. Adjuvant components derived from microbial products that were tested included threonyl-muramyl dipeptide (threonyl-MDP); monophosphoryl lipid A (MPL); trehalose dimycolate (TDM); and the delipidated, deproteinized, cell wall skeleton (CWS) from either Mycobacterium phlei or the BCG strain of Mycobacterium bovis. Nonmicrobially derived adjuvants tested included aluminum hydroxide and the lipid amine CP-20,961. In guinea pigs, all adjuvants and adjuvant mixtures enhanced antibody titers to PA as well as survival after a parenteral challenge of virulent B. anthracis Ames spores. In contrast, PA alone or combined with either aluminum hydroxide or CP-20,961 failed to protect mice. Vaccines containing PA combined with threonyl-MDP or MPL-TDM-CWS protected a majority of female CBA/J mice. Statistical analysis of survival data in the guinea pigs indicated that PA-MPL-CWS and PA-MPL-TDM-CWS were more efficacious than the currently licensed human anthrax vaccine. C1 USA,MED RES INST INFECT DIS,DIV INFORMAT MANAGEMENT,FREDERICK,MD 21702. RP IVINS, BE (reprint author), USA,MED RES INST INFECT DIS,DIV BACTERIOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 46 TC 108 Z9 113 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD FEB PY 1992 VL 60 IS 2 BP 662 EP 668 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA HA564 UT WOS:A1992HA56400051 PM 1730501 ER PT J AU ODONNELL, BP SPERLING, LC JAMES, WD AF ODONNELL, BP SPERLING, LC JAMES, WD TI LOOSE ANAGEN HAIR SYNDROME SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article AB This recently described entity begins in childhood and is characterized by actively growing hairs that can be easily and painlessly removed from the scalp, leading to alopecia. RP ODONNELL, BP (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 8 TC 20 Z9 23 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD FEB PY 1992 VL 31 IS 2 BP 107 EP 109 DI 10.1111/j.1365-4362.1992.tb03248.x PG 3 WC Dermatology SC Dermatology GA HC608 UT WOS:A1992HC60800010 PM 1559732 ER PT J AU FIELDS, CA NEWBERRY, JE PFEIFFER, HD SODERLUND, CA KIRBY, SF MCWILLIAMS, GB AF FIELDS, CA NEWBERRY, JE PFEIFFER, HD SODERLUND, CA KIRBY, SF MCWILLIAMS, GB TI MERCURY - A HETEROGENEOUS SYSTEM FOR SPATIAL EXTRAPOLATION OF MESOSCALE METEOROLOGICAL DATA SO INTERNATIONAL JOURNAL OF MAN-MACHINE STUDIES LA English DT Article ID KNOWLEDGE C1 USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP FIELDS, CA (reprint author), NEW MEXICO STATE UNIV,COMP RES LAB,LAS CRUCES,NM 88003, USA. OI Fields, Chris/0000-0002-4812-0744 NR 30 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0020-7373 J9 INT J MAN MACH STUD PD FEB PY 1992 VL 36 IS 2 BP 309 EP 326 DI 10.1016/0020-7373(92)90020-L PG 18 WC Computer Science, Cybernetics; Ergonomics; Psychology SC Computer Science; Engineering; Psychology GA HF683 UT WOS:A1992HF68300012 ER PT J AU BRODINE, SK OLDFIELD, EC CORWIN, AL THOMAS, RJ RYAN, AB HOLMBERG, J MOLGAARD, CA GOLBECK, AL RYDEN, LA BENENSON, AS ROBERTS, CR BLATTNER, WA AF BRODINE, SK OLDFIELD, EC CORWIN, AL THOMAS, RJ RYAN, AB HOLMBERG, J MOLGAARD, CA GOLBECK, AL RYDEN, LA BENENSON, AS ROBERTS, CR BLATTNER, WA TI HTLV-I AMONG UNITED-STATES MARINES STATIONED IN A HYPERENDEMIC AREA - EVIDENCE FOR FEMALE-TO-MALE SEXUAL TRANSMISSION SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HUMAN T-CELL LEUKEMIA LYMPHOMA VIRUS; SEXUALLY TRANSMITTED DISEASES ID CELL LEUKEMIA-VIRUS; TROPICAL SPASTIC PARAPARESIS; LYMPHOTROPIC VIRUS; DRUG-ABUSERS; BLOOD-DONORS; ANTIBODIES; INFECTION; LYMPHOMA; SEROPREVALENCE; RETROVIRUS AB Among 5,255 active duty United States Marines on permanent tour in Okinawa, Japan, screened for human T-cell leukemia/lymphoma virus type I (HTLV-I) seropositivity, 3 (0.06%) were confirmed by Western blot analysis to have core and envelope reactivity. All three seropositive individuals have a history of prolonged sexual contact with Okinawan women, and two of the three individuals are married to seropositive Okinawan wives. Two gave a prior history of gonorrhea, while all three were negative for syphilis (MHA-TP) and hepatitis B. No other risk factors associated with HTLV-I seropositivity in the United States were identified. A banked sample from one individual, obtained 8 months after initial sexual relations with his HTLV-I-seropositive Okinawan spouse and 20 months before being retested in the survey, showed a pattern suggesting seroconversion. Although based on small numbers, these data suggest that female-to-male transmission of HTLV-I occurs in the absence of other cofactors, e.g., ulcerative genital lesions. C1 NAVAL HOSP,US PACIFIC COMMAND JOINT BLOOD PROGRAM OFF,OKINAWA,JAPAN. USN HOSP,DEPT CLIN INVEST,SAN DIEGO,CA 92134. USN,MED RES & DEV COMMAND,BETHESDA,MD 20814. USN,ENVIRONM PREVENT MED UNIT 6,HONOLULU,HI. MARINE DIV 3,OKINAWA,JAPAN. SAN DIEGO STATE UNIV,GRAD SCH PUBL HLTH,SAN DIEGO,CA 92182. SAN DIEGO STATE UNIV,DEPT MATH SCI,SAN DIEGO,CA 92182. WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. NCI,VIRAL EPIDEMIOL SECT,BETHESDA,MD 20892. RP BRODINE, SK (reprint author), USN HOSP,DEPT INTERNAL MED,DIV INFECT DIS,SAN DIEGO,CA 92134, USA. NR 34 TC 10 Z9 10 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD FEB PY 1992 VL 5 IS 2 BP 158 EP 162 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA GZ902 UT WOS:A1992GZ90200010 PM 1732508 ER PT J AU PRIDHAM, KF CHANG, AS AF PRIDHAM, KF CHANG, AS TI TRANSITION TO BEING THE MOTHER OF A NEW INFANT IN THE 1ST 3 MONTHS - MATERNAL PROBLEM-SOLVING AND SELF-APPRAISALS SO JOURNAL OF ADVANCED NURSING LA English DT Article ID BEHAVIOR; PARENTHOOD; EMPLOYMENT; FAMILY; MODEL; BABY AB This study explored components of a model of transition to being the mother of a new infant during an infant's first 3 months. Personal and situational conditions and maternal problem-solving factors (issue formulating and the use of help with issues) that may influence transition markers (maternal appraisal of problem-solving competence and evaluation of parenting) were examined for two study periods: the first 30 days postpartum and the next 60 days. For the second study period, variables contributing to maternal attention to infant growth, development and temperament (knowing issues) were also explored. Questionnaires and a daily log kept by 62 mothers of healthy term infants were data sources. Everyday supports (situational condition) contributed to use of lay help for the second period. Caretaking issues positively influenced use of clinician help throughout the study. The number of knowing issues a mother formulated contributed positively to problem-solving competence and to parenting evaluation; the use of problem-solving help had no effect. More clinician help received during the first month meant higher need for maternal action for both knowing and caretaking issues in the second and third months. Further study of the mechanisms of these relationships and examination of factors contributing to shifts in the transition process are needed. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP PRIDHAM, KF (reprint author), UNIV WISCONSIN,SCH NURSING,600 HIGHLAND AVE,MADISON,WI 53792, USA. FU BHP HRSA HHS [R01 NU-00606] NR 48 TC 28 Z9 29 U1 1 U2 4 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0309-2402 J9 J ADV NURS JI J. Adv. Nurs. PD FEB PY 1992 VL 17 IS 2 BP 204 EP 216 DI 10.1111/j.1365-2648.1992.tb01875.x PG 13 WC Nursing SC Nursing GA HC714 UT WOS:A1992HC71400010 PM 1556329 ER PT J AU ORGILL, MM KINCHELOE, JD SUTHERLAND, RA AF ORGILL, MM KINCHELOE, JD SUTHERLAND, RA TI MESOSCALE INFLUENCES ON NOCTURNAL VALLEY DRAINAGE WINDS IN WESTERN COLORADO VALLEYS SO JOURNAL OF APPLIED METEOROLOGY LA English DT Article ID TRACER AB The mesoalpha-scale upper-level sounding network data collected during the 1984 ASCOT meteorlogical and tracer experiments provided a unique opportunity to analyze the nocturnal drainage wind in four different valleys in western Colorado, and to examine the effects of the synoptic- and mesoscale ambient conditions on these valley drainage winds. The six experimental periods, although biased because of a "fair weather" selection process, provided an additional opportunity to examine "good" and "poor" drainage scenarios. The results show that drainage winds fill all four valleys up to 80%-100% of their valley depths under favorable nocturnal radiative longwave cooling (1.0-degrees-1.5-degrees-C h-1) and light (< 5 m s-1) ambient winds. Valley drainage, once established, is rather resistant to erosion from above because of the large source regions of these valleys, their large volume fluxes and inertia, and the persistent stable conditions inside these valleys. Wind erosion was observed on three nights when the drainage depth was reduced to less than half of the valley depth. The principal contributing factors to wind erosion processes were above-valley along-valley wind component opposing the drainage, valley stability, height of the 5 m s-1 isotach above the valley, and total above-valley wind acceleration. Generally, wind erosion processes appear to be especially active when above-valley wind speeds exceed 5 m s-1 and accelerations exceed 0.00040 m s-2. Other contributing factors that cause variable or terminated drainage depths are precipitation-evaporation effects causing nonradiative drainage events, wind shear above the valley, cloudiness, frontal passages, and synoptic winds directed in the down-valley direction. C1 USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. NEW MEXICO STATE UNIV,LAS CRUCES,NM 88003. NR 16 TC 8 Z9 8 U1 0 U2 3 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0894-8763 J9 J APPL METEOROL JI J. Appl. Meteorol. PD FEB PY 1992 VL 31 IS 2 BP 121 EP 141 DI 10.1175/1520-0450(1992)031<0121:MIONVD>2.0.CO;2 PG 21 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA HE943 UT WOS:A1992HE94300001 ER PT J AU ADLER, M DESHPANDE, SS FOSTER, RE MAXWELL, DM ALBUQUERQUE, EX AF ADLER, M DESHPANDE, SS FOSTER, RE MAXWELL, DM ALBUQUERQUE, EX TI EFFECTS OF SUBACUTE PYRIDOSTIGMINE ADMINISTRATION ON MAMMALIAN SKELETAL-MUSCLE FUNCTION SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE EXTENSOR DIGITORUM LONGUS; DIAPHRAGM; TWITCH TENSION; ACH RELEASE; SUBACUTE; ALZET PUMPS; TOLERANCE; ANTICHOLINESTERASE; PYRIDOSTIGMINE; SOMAN ID IONIC CHANNEL COMPLEX; PROTECTION; SOMAN; PRETREATMENT; ANIMALS AB The subacute effects of pyridostigmine bromide were investigated on the contractile properties of rat extensor digitorum longus (EDL) and diaphragm muscles. The cholinesterase inhibitor was delivered via subcutaneously implanted osmotic minipumps (Alzet(R)) at 9-mu-g h-1 (low dose) or 60-mu-g h-1 (high dose). Animals receiving high-dose pyridostigmine pumps exhibited marked alterations in muscle properties within the first day of exposure that persisted for the remaining 13 days. With 0.1 Hz stimulation, EDL twitch tensions of treated animals were elevated relative to control. Repetitive stimulation at frequencies > 1 Hz led a use-dependent depression in the amplitude of successive twitches during the train. Recovery from pyridostigmine was essentially complete by 1 day of withdrawal. Rats implanted with low-dose pyridostigmine pumps showed little or no alteration of in vivo twitch tensions during the entire 14 days of treatment. Diaphragm and EDL muscles excised from pyridostigmine-treated rats and tested in vitro showed no significant alterations in twitch and tetanic tensions and displayed the same sensitivity as muscles of control animals to subsequent pyridostigmine exposures. In the presence of atropine, subacutely administered pyridostigmine protected rats from two LD50 doses of the irreversible cholinesterase inhibitor, soman. In the absence of atropine, the LD50 of soman was not altered by subacute pyridostigmine treatment. C1 USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201. RP ADLER, M (reprint author), USA,MED RES INST CHEM DEF,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 28 TC 10 Z9 10 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD FEB PY 1992 VL 12 IS 1 BP 25 EP 33 DI 10.1002/jat.2550120107 PG 9 WC Toxicology SC Toxicology GA HA973 UT WOS:A1992HA97300005 PM 1564249 ER PT J AU DRESSER, TH RIVERA, ER HOFFMANN, FJ FINCH, RA AF DRESSER, TH RIVERA, ER HOFFMANN, FJ FINCH, RA TI TERATOGENIC ASSESSMENT OF 4 SOLVENTS USING THE FROG EMBRYO TERATOGENESIS ASSAY - XENOPUS (FETAX) SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE XENOPUS; FETAX; TERATOGENICITY; SOLVENTS; ETHANOL; DIMETHYL SULFOXIDE; FORMAMIDE; GLYCEROL FORMAL ID METABOLIC-ACTIVATION SYSTEM; DEVELOPMENTAL TOXICITY; ETHANOL; IDENTIFICATION; EMBRYOTOXICITY; MALFORMATION; VALIDATION; EXPOSURE; INVITRO AB The Frog Embryo Teratogenesis Assay-Xenopus (FETAX) was used to assess the teratogenic potential of four solvents. Embryos of the South African clawed frog, Xenopus laevis, were exposed for 96 h to ethanol, dimethyl sulfoxide (DMSO), formamide or glycerol formal. Exposure groups were maintained using a static renewal system in which the exposure media were changed at 24-h intervals. Survival was monitored at 24-h intervals. Length, as an indicator of growth effects, and developmental malformations were determined at the end of the assay (96 h). Using this information, the 96-h LC50, the 96-h EC50 (Malformation), and the no observable effect levels (NOELs) for mortality, malformation and length were determined for each solvent. The teratogenic index [TI = 96-h LC50/96-h EC50 (Malformation)] also was calculated for each of the solvents. DMSO appeared to be the least toxic or teratogenic solvent examined, with a pooled LC50 of 1.92%, a pooled EC50 (Malformation) of 1.57% and TI values of 1.20 and 1.24 in replicate trials. Formamide appeared to be the most toxic solvent, with a pooled LC50 of 1.04%. Data trends suggested that ethanol was the most teratogenic solvent tested, with a pooled EC50 (Malformation) of 1.04% and TI values of 1.42 and 1.50. The results obtained in the present work for ethanol and DMSO were compared to previously published FETAX results for these two solvents. The present results are in close agreement with these results from other laboratories, thus providing further evidence supporting the interlaboratory reproducibility of FETAX results. C1 USA,BIOMED RES & DEV LAB,DIV HLTH EFFECTS RES,FREDERICK,MD 21702. NR 47 TC 33 Z9 33 U1 2 U2 9 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD FEB PY 1992 VL 12 IS 1 BP 49 EP 56 DI 10.1002/jat.2550120111 PG 8 WC Toxicology SC Toxicology GA HA973 UT WOS:A1992HA97300009 PM 1564253 ER PT J AU ORLANDI, PA KLOTZ, FW HAYNES, JD AF ORLANDI, PA KLOTZ, FW HAYNES, JD TI A MALARIA INVASION RECEPTOR, THE 175-KILODALTON ERYTHROCYTE BINDING ANTIGEN OF PLASMODIUM-FALCIPARUM RECOGNIZES THE TERMINAL NEU5AC(ALPHA-2-3)GAL- SEQUENCES OF GLYCOPHORIN-A SO JOURNAL OF CELL BIOLOGY LA English DT Article ID INFLUENZA-VIRUS; SIALIC-ACID; POLYACRYLAMIDE GELS; MEROZOITE INVASION; MEMBRANE-PROTEINS; FILM DETECTION; IMMUNE SERUM; SURFACE; PARASITES; CELL AB Plasmodium falciparum malaria parasites invade human erythrocytes by means of a parasite receptor for erythrocytes, the 175-kD erythrocyte binding antigen (EBA-175). Similar to invasion efficiency, binding requires N-acetylneuraminic acid (Neu5Ac) on human erythrocytes, specifically the glycophorins. EBA-175 bound to erythrocytes with receptor-like specificity and was saturable. The specificity of EBA-175 binding was studied to determine if its binding is influenced either by simple electrostatic interaction with the negatively charged Neu5Ac (on the erythrocyte surface); or if Neu5Ac indirectly affected the conformation of an unknown ligand, or if Neu5Ac itself in specific linkage and carbohydrate composition was the primary ligand for EBA-175 as demonstrated for hemagglutinins of influenza viruses. Most Neu5Ac on human erythrocytes is linked to galactose by alpha-2-3 and alpha-2-6 linkages on glycophorin A. Soluble Neu5Ac by itself in solution did not competitively inhibit the binding of EBA-175 to erythrocytes, suggesting that linkage to an underlying sugar is required for binding in contrast to charge alone. Binding was competitively inhibited only by Neu5Ac(alpha-2-3)Gal-containing oligosaccharides. Similar oligosaccharides containing Neu5Ac(alpha-2-6)Gal-linkages had only slight inhibitory effects. Binding inhibition assays with modified sialic acids and other saccharides confirmed that oligosaccharide composition and linkage were primary factors for efficient binding. EBA-175 bound tightly enough to glycophorin A that the complex could be precipitated with an anti-glycophorin A monoclonal antibody. Selective cleavage of O-linked tetrasaccharides clustered at the NH2 terminus of glycophorin A markedly reduced binding in inhibition studies. We conclude that the Neu5Ac(a-2,3)Gal- determinant on O-linked tetrasaccharides of glycophorin A appear to be the preferential erythrocyte ligand for EBA-175. C1 WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. NR 46 TC 170 Z9 172 U1 3 U2 4 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 SN 0021-9525 J9 J CELL BIOL JI J. Cell Biol. PD FEB PY 1992 VL 116 IS 4 BP 901 EP 909 DI 10.1083/jcb.116.4.901 PG 9 WC Cell Biology SC Cell Biology GA HD550 UT WOS:A1992HD55000006 PM 1310320 ER PT J AU PAYNE, EW AF PAYNE, EW TI MICROSCALE SYNTHESIS OF 2,6-BIS(MORPHOLINOMETHYL)-PARA-CRESOL - A PHENOLIC MANNICH BASE SO JOURNAL OF CHEMICAL EDUCATION LA English DT Article RP PAYNE, EW (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 8 TC 2 Z9 2 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0021-9584 J9 J CHEM EDUC JI J. Chem. Educ. PD FEB PY 1992 VL 69 IS 2 BP A40 EP A41 PG 2 WC Chemistry, Multidisciplinary; Education, Scientific Disciplines SC Chemistry; Education & Educational Research GA HH527 UT WOS:A1992HH52700001 ER PT J AU LAL, RB BRODINE, S KAZURA, J MBIDDEKATONGA, E YANAGIHARA, R ROBERTS, C AF LAL, RB BRODINE, S KAZURA, J MBIDDEKATONGA, E YANAGIHARA, R ROBERTS, C TI SENSITIVITY AND SPECIFICITY OF A RECOMBINANT TRANSMEMBRANE GLYCOPROTEIN (RGP21)-SPIKED WESTERN IMMUNOBLOT FOR SEROLOGICAL CONFIRMATION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II INFECTIONS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID ANTIBODY REACTIVITY; ENVELOPE PROTEIN; HTLV; SEQUENCE; PEPTIDE; DONORS; ASSAYS; BLOOD AB Serum specimens (n = 2,712) obtained from individuals residing in diverse geographic regions and categorized as seropositve (n = 122), seroindeterminate (n = 523), or seronegative (n = 2,067) for human T-cell lymphotropic virus (HTLV) infection in accordance with U.S. Public Health Service guidelines were retested by recombinant transmembrane protein (rgp21)-spiked Western immunoblotting. Of the 122 HTLV-positive specimens, those from 85 of 85 (100%) U.S. blood donors, 2 of 2 (100%) Brazilians, 1 of 2 (50%) Indonesians, 14 of 14 (100%) Solomon Islanders, and 18 of 19 (95%) Papua New Guineans reacted with rgp21, yielding an overall sensitivity of 98% (120 of 122). Specimens from individuals whose infections were confirmed to be HTLV type I or HTLV type II by the polymerase chain reaction assay reacted equally well with rgp21. Of the 523 HTLV-indeterminate specimens, those from 21 of 379 (5.5%) U.S. blood donors, 3 of 6 (50%) Brazilians, 10 of 23 (44%) Ugandans, 8 of 49 (16%) Indonesians, 4 of 36 (11%) Solomon Islanders, and 5 of 30 (17%) Papua New Guineans reacted with rgp21. None of these 51 specimens reacted with native gp46 and/or gp61/68 in a radioimmunoprecipitation assay, suggesting a false-positive reaction (9.75%). Of the 2,067 HTLV-negative specimens, 12 reacted with rgp21, yielding a false-positivity rate of 0.6%. These data indicate that while detection of rgp21 is highly sensitive, it can yield false-positive results. Thus, specimens exhibiting reactivity with rgp21 in the absence of reactivity with native gp46 and/or gp61/68 by Western blot should be tested further by a radioimmunoprecipitation assay to verify HTLV type I or type II infection. C1 USN,HLTH RES CTR,DIV INFECT DIS,SAN DIEGO,CA 92132. CASE WESTERN RESERVE UNIV,DEPT MED,DIV GEOG MED,CLEVELAND,OH 44106. MAKERERE UNIV,UGANDA CANC INST,KAMPALA,UGANDA. NINCDS,CENT NERVOUS SYST STUDIES LAB,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DEPT DIAGNOST RETORVIROL,WASHINGTON,DC 20307. RP LAL, RB (reprint author), CTR DIS CONTROL,CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,RETROVIRUS DIS BRANCH,ATLANTA,GA 30333, USA. NR 25 TC 43 Z9 45 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD FEB PY 1992 VL 30 IS 2 BP 296 EP 299 PG 4 WC Microbiology SC Microbiology GA HA100 UT WOS:A1992HA10000007 PM 1347047 ER PT J AU GEISBERT, TW JAHRLING, PB HANES, MA ZACK, PM AF GEISBERT, TW JAHRLING, PB HANES, MA ZACK, PM TI ASSOCIATION OF EBOLA-RELATED RESTON VIRUS-PARTICLES AND ANTIGEN WITH TISSUE LESIONS OF MONKEYS IMPORTED TO THE UNITED-STATES SO JOURNAL OF COMPARATIVE PATHOLOGY LA English DT Article ID HEMORRHAGIC-FEVER; PATHOLOGY C1 USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702. RP GEISBERT, TW (reprint author), USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21702, USA. NR 18 TC 100 Z9 103 U1 0 U2 6 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0021-9975 J9 J COMP PATHOL JI J. Comp. Pathol. PD FEB PY 1992 VL 106 IS 2 BP 137 EP 152 DI 10.1016/0021-9975(92)90043-T PG 16 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA HL114 UT WOS:A1992HL11400003 PM 1597531 ER PT J AU SCOTT, AC VIRE, DE AF SCOTT, AC VIRE, DE TI AN EVALUATION OF THE ABILITY OF A DENTIN PLUG TO CONTROL EXTRUSION OF THERMOPLASTICIZED GUTTA-PERCHA SO JOURNAL OF ENDODONTICS LA English DT Article ID ROOT-CANAL OBTURATION; SEALING ABILITY; APICAL SEAL; PLACEMENT AB Overextension of gutta-percha when using any of the thermoplasticized obturation techniques has often been mentioned as a possible deleterious yet common sequela. The purpose of this study was to test a means of controlling the extrusion of material at the apical seat of the preparation when thermoplasticized gutta-percha techniques are used. Eighty human maxillary central incisors were prepared via step-back technique, in vitro, with apical stops placed 1 mm short of the actual apical foramen and the foramen was checked for patency. Teeth were divided into 10 groups, embedded in special "tooth trays," and four groups had intentional dentin plugs of 1-mm thickness placed to enhance the apical stop. A tooth tray of patent teeth and one of dentin-plugged teeth were than obturated by (a) the Obtura technique, (b) the Ultrafil technique, (c) the Touch'n Heat technique, and (d) the Thermafil technique. Teeth were removed from the trays, extruded material carefully excised and weighed, and the weights evaluated by statistical analysis to determine results. When foramen patency was maintained, the Thermafil technique demonstrated significantly greater problems with overextension of material than did other techniques. The dentin plug served as an effective means of preventing extrusion. RP SCOTT, AC (reprint author), USA,DENTAC,FT BRAGG,NC 28307, USA. NR 19 TC 7 Z9 8 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD FEB PY 1992 VL 18 IS 2 BP 52 EP 57 DI 10.1016/S0099-2399(06)81370-1 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HJ424 UT WOS:A1992HJ42400002 PM 19186418 ER PT J AU WILLIAMS, RT ZIEGENFUSS, PS SISK, WE AF WILLIAMS, RT ZIEGENFUSS, PS SISK, WE TI COMPOSTING OF EXPLOSIVES AND PROPELLANT CONTAMINATED SOILS UNDER THERMOPHILIC AND MESOPHILIC CONDITIONS SO JOURNAL OF INDUSTRIAL MICROBIOLOGY LA English DT Article DE COMPOSTING; EXPLOSIVES; PROPELLANTS; THERMOPHILIC; MESOPHILIC; BIOREMEDIATION AB Composting was investigated as a bioremediation technology for clean-up of sediments contaminated with explosives and propellants. Two field demonstrations were conducted, the first using 2,4,6-trinitrotoluene (TNT), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetraazocine (HMX), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and N-methyl-N,2,4,6-tetranitroaniline (tetryl) contaminated sediment, and the second using nitrocellulose (NC) contaminated soil. Tests were conducted in thermophilic and mesophilic aerated static piles. Extractable TNT was reduced from 11 840 mg/kg to 3 mg/kg, and NC from 13 090 mg/kg to 16 mg/kg under thermophilic conditions. Under mesophilic conditions, TNT was reduced from 11 190 mg/kg to 50 mg/kg. The thermophilic and mesophilic half-lives were 11.9 and 21.9 days for TNT, 17.3 and 30.1 days for RDX, and 22.8 and 42.0 days for HMX, respectively. Known nitroaromatic transformation products increased in concentration over the first several weeks of the test period, but decreased to low concentrations thereafter. C1 USA,TOX & HAZARDOUS MAT AGCY,ABERDEEN PROVING GROUND,MD 21010. RP WILLIAMS, RT (reprint author), ROY F WESTON INC,1 WESTON WAY,W CHESTER,PA 19380, USA. NR 13 TC 75 Z9 77 U1 0 U2 4 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0169-4146 J9 J IND MICROBIOL JI J. Indust. Microbiol. PD FEB-MAR PY 1992 VL 9 IS 2 BP 137 EP 144 DI 10.1007/BF01569746 PG 8 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA HP671 UT WOS:A1992HP67100010 ER PT J AU ROSENBERG, YJ SHAFFERMAN, A WHITE, BD PAPERMASTER, SF LEON, E EDDY, GA BENVENISTE, R BURKE, DS LEWIS, MG AF ROSENBERG, YJ SHAFFERMAN, A WHITE, BD PAPERMASTER, SF LEON, E EDDY, GA BENVENISTE, R BURKE, DS LEWIS, MG TI VARIATION IN THE CD4+ AND CD8+ POPULATIONS IN LYMPH-NODES DOES NOT REFLECT THAT IN THE BLOOD DURING SIV(MNE/E11S) INFECTION OF MACAQUES SO JOURNAL OF MEDICAL PRIMATOLOGY LA English DT Article; Proceedings Paper CT 4TH MEETING ON NONHUMAN PRIMATE MODELS FOR AIDS CY NOV 06-09, 1991 CL WASHINGTON REG PRIMATE RES CTR, SEATTLE, WA HO WASHINGTON REG PRIMATE RES CTR DE CD4+; CD8+ CELLS; LYMPH NODES; BLOOD; SIV; RHESUS MACAQUES ID IMMUNODEFICIENCY VIRUS; LYMPHOCYTES-T; AIDS; SUBSETS; UCHL1 AB The decline in the CD4% and CD4/CD8 ratios have been compared in lymph nodes and blood from SIV(MNE/E11S) infected rhesus macaques. The results indicate that loss from the LN CD4+ cell pool does not occur until CD4/CD8 ratios of < 0.5 is reached in blood. These changes also correlate with the ability to isolate virus from the blood and the transition of CD45RA(hi) to highly activated CD45RA(lo) CD8+ cells both of which may play a role in eliminating CD4+ cells. In end-stage disease, CD8+ cells also decline in LN and mitogen responsiveness no longer exists in any nodes. Interestingly at this stage, the circulating CD8% increases significantly and represents the only source of functional T cells remaining in the body. C1 NCI,FREDERICK CANC RES FACIL,FREDERICK,MD 21701. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP ROSENBERG, YJ (reprint author), HENRY M JACKSON FDN RES LAB,1500 E GUDE DR,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 21 TC 14 Z9 14 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0047-2565 J9 J MED PRIMATOL JI J. Med. Primatol. PD FEB-MAY PY 1992 VL 21 IS 2-3 BP 131 EP 137 PG 7 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA HW208 UT WOS:A1992HW20800014 PM 1359148 ER PT J AU TICEHURST, J POPKIN, TJ BRYAN, JP INNIS, BL DUNCAN, JF AHMED, A IQBAL, M MALIK, I KAPIKIAN, AZ LEGTERS, LJ PURCELL, RH AF TICEHURST, J POPKIN, TJ BRYAN, JP INNIS, BL DUNCAN, JF AHMED, A IQBAL, M MALIK, I KAPIKIAN, AZ LEGTERS, LJ PURCELL, RH TI ASSOCIATION OF HEPATITIS-E VIRUS WITH AN OUTBREAK OF HEPATITIS IN PAKISTAN - SEROLOGIC RESPONSES AND PATTERN OF VIRUS EXCRETION SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE ENTERICALLY TRANSMITTED NON-A; NON-B (ET-NANB) HEPATITIS; EPIDEMIC; IMMUNE ELECTRON MICROSCOPY (IEM); ANTIBODY; VIRUS PARTICLES ID NON-B-HEPATITIS; TRANSMITTED NON-A; IMMUNE ELECTRON-MICROSCOPY; CYNOMOLGUS MACAQUES; PARTICLES; EPIDEMIC; ANTIGEN; GASTROENTERITIS; IDENTIFICATION; QUANTITATION AB Hepatitis E virus (HEV), a positive-strand RNA agent, has been associated with enterically transmitted non-A, non-B hepatitis in Asia, Africa, and Mexico. To evaluate the role of HEV in an outbreak of hepatitis in Pakistan, we used immune electron microscopy to detect 1) antibody to HEV, for evidence of infection, and 2) virus, to determine the pattern of HEV excretion. Paired sera from 2 patients were assayed for antibody by using reference HEV: one seroconverted, an atypical finding for HEV infections; the other had high levels of anti-HEV in both sera. Virus particles with the size (29 x 31 nm) and morphology of HEV were detected in feces from 10 of 85 patients and serologically identified as HEV by using reference antibodies from an HEV infected chimpanzee. One of these HEV-containing specimens was collected 9 days before the onset of jaundice; it was among feces from 38 outpatients with nonspecific symptoms and biochemical hepatitis, 12 of whom subsequently developed jaundice. The other 9 feces with HEV were among 36 collected within 7 days of the onset of acute icteric hepatitis; all 11 feces from days 8 to 15 were negative for HEV. Fecal concentrations of HEV appeared to be lower than those of many enteric viruses: only one specimen contained as many as 5 particles per EM grid square. It is concluded that HEV was etiologically associated with the epidemic and was predominantly excreted at very low levels during the first week of jaundice. C1 NIAID,INFECT DIS LAB,BETHESDA,MD 20892. UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR,BETHESDA,MD 20814. ARMED FORCE INST MED SCI,DEPT VIROL,BANGKOK,THAILAND. ARMY MED COLL,PAKISTAN US LAB SEROEPIDEMIOL,RAWALPINDI,PAKISTAN. RP TICEHURST, J (reprint author), WALTER REED ARMY MED CTR,DEPT VIRAL DIS,WASHINGTON,DC 20307, USA. RI Ticehurst, John/I-7532-2012 NR 50 TC 51 Z9 51 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD FEB PY 1992 VL 36 IS 2 BP 84 EP 92 DI 10.1002/jmv.1890360205 PG 9 WC Virology SC Virology GA HB785 UT WOS:A1992HB78500004 PM 1583470 ER PT J AU KHANNA, B SPELBRING, JE INNIS, BL ROBERTSON, BH AF KHANNA, B SPELBRING, JE INNIS, BL ROBERTSON, BH TI CHARACTERIZATION OF A GENETIC VARIANT OF HUMAN HEPATITIS-A VIRUS SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE NUCLEIC ACID SEQUENCE; GENETIC VARIABILITY; GENOTYPE; ANIMAL INFECTIVITY ID NUCLEOTIDE-SEQUENCE; GENOMIC SEQUENCES; CLASSIFICATION; POLYMERASE; STRAINS; CLONING AB Human isolates of hepatitis A (HAV) are a single serotype; however, recent genetic surveys using limited nucleotide sequencing have provided evidence that more than one genotype is responsible for HAV infection in different parts of the world (Jansen et al. [1990]: Proc Natl Acad Sci USA 87:2867-2871; Robertson et al. [1991] J Infect Dis 163:286-292). One of these genotypes was originally isolated from Panamanian owl monkeys (strain PA21), but has subsequently been found associated with human cases of HAV from Sweden in 1979 (H-122) and the United States of America in 1976 (GA76). The nucleic acid sequence of the exposed capsid polypeptide region of GA76 differs from other human HAV sequences by approximately 20%, yet differs by only 2.4% when compared with P1 sequence of the PA21 strain. The 20% nucleic acid variability between GA76 and other human HAV results in limited amino acid changes (3%), while a comparison with PA21 revealed only four homologous amino acid substitutions within VP2, VP3, and VP1 polypeptides. HAV infected stool specimens from Nepal and northern India during 1989 and 1990 were found to contain virus whose genetic makeup was related to the PA21 and GA76 isolates. This genotype of HAV appears to be circulating in some parts of the world where HAV is hyperendemic, and is a potential cause of hepatitis A infection within a susceptible population. C1 ARMED FORCES RES INST MED SCI,USA MED COMPONENT,BANGKOK,THAILAND. RP KHANNA, B (reprint author), CTR DIS CONTROL,CTR INFECT DIS,WHO,COLLABORATING CTR RES & REFERENCE VIRAL HEPATITIS,ATLANTA,GA 30333, USA. NR 30 TC 32 Z9 34 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD FEB PY 1992 VL 36 IS 2 BP 118 EP 124 DI 10.1002/jmv.1890360208 PG 7 WC Virology SC Virology GA HB785 UT WOS:A1992HB78500007 PM 1316423 ER PT J AU TELLER, DC MURPHY, TP AF TELLER, DC MURPHY, TP TI BILATERAL FACIAL PARALYSIS - A CASE PRESENTATION AND LITERATURE-REVIEW SO JOURNAL OF OTOLARYNGOLOGY LA English DT Article AB Bilateral facial paralysis is a diagnostic challenge, which may manifest itself as either a simultaneous or alternating form, occurring in 0.3-2.0% of patients that present with facial paralysis. The differential diagnosis of facial paralysis includes congenital, traumatic, neurologic, infectious, metabolic, neoplastic, toxic, iatrogenic and idiopathic etiologies. While idiopathic facial paralysis is the most common diagnosis, a comprehensive evaluation must be completed prior to this diagnosis in patients with bilateral facial paralysis. A representative case of simultaneous bilateral facial paralysis is presented. The literature is reviewed and discussed. A diagnostic protocol for the evaluation of bilateral facial paralysis is proposed. Bilateral facial paralysis requires a thorough evaluation and may prove to be a diagnostic dilemma. RP TELLER, DC (reprint author), BROOKE ARMY MED CTR,DEPT SURG,OTOLARYNGOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 25 Z9 26 U1 0 U2 0 PU DECKER PERIODICALS INC PI HAMILTON PA 4 HUGHSON STREET SOUTH PO BOX 620, LCD 1, HAMILTON ON L8N 3K7, CANADA SN 0381-6605 J9 J OTOLARYNGOL JI J. Otolaryngol. PD FEB PY 1992 VL 21 IS 1 BP 44 EP 47 PG 4 WC Otorhinolaryngology SC Otorhinolaryngology GA HE406 UT WOS:A1992HE40600008 PM 1564749 ER PT J AU PLICHTA, EJ BEHL, WK AF PLICHTA, EJ BEHL, WK TI HIGH-RATE MOLTEN-SALT CELLS EMPLOYING BARIUM NICKEL SULFIDE CATHODES SO JOURNAL OF POWER SOURCES LA English DT Article ID ELECTRODES AB Barium nickel sulfide (BaNiS2) was investigated as a cathode material in high temperature molten salt cells using lithium-aluminum alloy as the anode and a eutectic mixture of lithium chloride and potassium chloride immobilized with magnesium oxide as the electrolyte. Results are presented on the cathode utilization, cathode energy and power densities obtained at current densities of 0.05 to 2.0 A/cm2 at 400-degrees-C. The performance of these cells is also compared with the performance of similar cells using nickel monosulfide or its mixture with barium sulfide as cathodes. The electrode reactions occurring at the positive electrode in these cells during charge and discharge operations are also discussed. C1 USA,ELECTR TECHNOL & DEVICES LAB,LABCOM,FT MONMOUTH,NJ 07703. NR 9 TC 5 Z9 5 U1 2 U2 7 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD FEB PY 1992 VL 37 IS 3 BP 325 EP 333 DI 10.1016/0378-7753(92)85016-4 PG 9 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA HG105 UT WOS:A1992HG10500003 ER PT J AU ADRIAN, ED KRANTZ, WA IVANHOE, JR AF ADRIAN, ED KRANTZ, WA IVANHOE, JR TI THE USE OF PROCESSED SILICONE TO RETAIN THE IMPLANT-SUPPORTED TISSUE-BORNE OVERDENTURE SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB A technique is described for constructing the implant-retained overdenture with heat-polymerized silicone that is processed around undercuts in a round bar framework connecting the implants. An acrylic resin circular rest contacting the bar ensures that the implants are loaded in occlusion for stress distribution over the fixtures. C1 USA DENTAC,REMOVABLE PROSTHODONT SERV,FT GORDON,GA. EMORY UNIV,SCH POSTGRAD MED,DEPT PROSTHODONT,ATLANTA,GA 30322. NR 2 TC 12 Z9 12 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD FEB PY 1992 VL 67 IS 2 BP 219 EP 222 DI 10.1016/0022-3913(92)90457-L PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HB902 UT WOS:A1992HB90200015 PM 1538330 ER PT J AU BESSER, MJ POSEY, DM AF BESSER, MJ POSEY, DM TI CYSTIC TERATOMA IN A SUPERNUMERARY OVARY OF THE GREATER OMENTUM - A CASE-REPORT SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article AB Supernumerary ovary is a rarely described gynecologic finding. A 47-year-old woman presented with abdominal pain and a palpable lower abdominal mass. The mass, removed in a partial omentectomy, was found to consist of a supernumerary ovary with a cystic teratoma. C1 BRIGHAM & WOMENS HOSP,DEPT OBSTET & GYNECOL,BOSTON,MA 02115. TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859. NR 15 TC 16 Z9 17 U1 1 U2 1 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA P.O. DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 SN 0024-7758 J9 J REPROD MED JI J. Reprod. Med. PD FEB PY 1992 VL 37 IS 2 BP 189 EP 193 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA HE650 UT WOS:A1992HE65000020 PM 1538369 ER PT J AU ANDERSON, LL THOMAS, DE BERGER, TG VUKELJA, SJ AF ANDERSON, LL THOMAS, DE BERGER, TG VUKELJA, SJ TI CUTANEOUS PIGMENTATION AFTER DAUNORUBICIN CHEMOTHERAPY SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note ID NAIL PIGMENTATION RP ANDERSON, LL (reprint author), BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 9 TC 6 Z9 6 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD FEB PY 1992 VL 26 IS 2 BP 255 EP 256 DI 10.1016/S0190-9622(08)80301-5 PN 1 PG 2 WC Dermatology SC Dermatology GA HB885 UT WOS:A1992HB88500022 PM 1552062 ER PT J AU SHARKEY, MJ GRABSKI, WJ MCCOLLOUGH, ML BERGER, TG AF SHARKEY, MJ GRABSKI, WJ MCCOLLOUGH, ML BERGER, TG TI POSTCOITAL APPEARANCE OF A MEDIAN RAPHE CYST SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note RP SHARKEY, MJ (reprint author), BROOKE ARMY MED CTR,DEPT DERMATOL,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 10 Z9 10 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD FEB PY 1992 VL 26 IS 2 BP 273 EP 274 DI 10.1016/S0190-9622(08)80313-1 PN 1 PG 2 WC Dermatology SC Dermatology GA HB885 UT WOS:A1992HB88500034 PM 1552074 ER PT J AU HEIMER, WL BRAUNER, G JAMES, WD AF HEIMER, WL BRAUNER, G JAMES, WD TI DERMATOPATHIA PIGMENTOSA RETICULARIS - A REPORT OF A FAMILY DEMONSTRATING AUTOSOMAL DOMINANT INHERITANCE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article AB Dermatopathia pigmentosa reticularis is a rare heritable disorder consisting of a triad of cutaneous findings including reticulate hyperpigmentation, noncicatricial alopecia, and onychodystrophy. In addition to this triad, other variable features of dermatopathia pigmentosa reticularis have been described, including adermatoglyphia, hypohidrosis or hyperhidrosis, and palmoplantar hyperkeratosis. Only 10 cases have been described in the world literature to date, and no clear inheritance pattern has been demonstrated. We present a patient with the classic features of the dermatopathia pigmentosa reticularis triad, along with adermatoglyphia, hypohidrosis, and punctate hyperkeratosis of the palms and soles. A family pedigree demonstrates the autosomal dominant inheritance of dermatopathia pigmentosa reticularis. C1 NEW YORK MED COLL,DEPT DERMATOL,VALHALLA,NY 10595. RP HEIMER, WL (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 10 TC 27 Z9 27 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD FEB PY 1992 VL 26 IS 2 BP 298 EP 301 DI 10.1016/0190-9622(92)70039-I PN 2 PG 4 WC Dermatology SC Dermatology GA HB886 UT WOS:A1992HB88600005 PM 1303619 ER PT J AU MALANE, SL SAU, P BENSON, PM AF MALANE, SL SAU, P BENSON, PM TI EPITHELIOID HEMANGIOENDOTHELIOMA ASSOCIATED WITH REFLEX SYMPATHETIC DYSTROPHY SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID CARCINOMA AB A patient with long-standing reflex sympathetic dystrophy of the foot developed an aggressive epithelioid hemangioendothelioma of the involved extremity. The tumor metastasized to a regional lymph node and later to the lungs. The features of epithelioid hemangioendothelioma and reflex sympathetic dystrophy are reviewed. RP MALANE, SL (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 14 TC 21 Z9 21 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD FEB PY 1992 VL 26 IS 2 BP 325 EP 328 DI 10.1016/0190-9622(92)70047-J PN 2 PG 4 WC Dermatology SC Dermatology GA HB886 UT WOS:A1992HB88600013 PM 1569252 ER PT J AU BHATT, RT AF BHATT, RT TI OXIDATION EFFECTS ON THE MECHANICAL-PROPERTIES OF A SIC-FIBER-REINFORCED REACTION-BONDED SI3N4 MATRIX COMPOSITE SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID STRENGTH AB The room-temperature mechanical properties of a SiC-fiber-reinforced reaction-bonded silicon nitride composite were measured after 100 h treatment in nitrogen and oxygen environments to 1400-degrees-C. The composite heat-treated in nitrogen to 1400-degrees-C showed no appreciable loss in properties. In contrast, composites heat-treated in oxygen from 600-degrees to 1000-degrees-C retained approximately 65% and 35% of the matrix fracture and ultimate strength, respectively, of the as-fabricated composites, and those heat-treated from 1200-degrees to 1400-degrees-C retained greater than 90% and 65% of the matrix fracture and ultimate strength, respectively, of the as-fabricated composites. For all nitrogen and oxygen treatments, the composite displayed strain capability beyond the matrix fracture strength. Oxidation of the fiber surface coating, which caused degradation of bond between the fiber and matrix and reduction in fiber strength, appears to be the dominant mechanism for property degradation of the composites oxidized from 600-degrees to 1000-degrees-C. Formation of a protective silica coating at external surfaces of the composites at and above 1200-degrees-C reduced oxidation of the fiber coating and hence degrading effects of oxidation on their properties. RP USA, AVIAT RES & TECHNOL ACTIV, AVSCOM, PROPULS LAB, LEWIS RES CTR, CLEVELAND, OH 44135 USA. NR 17 TC 22 Z9 22 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD FEB PY 1992 VL 75 IS 2 BP 406 EP 412 DI 10.1111/j.1151-2916.1992.tb08194.x PG 7 WC Materials Science, Ceramics SC Materials Science GA HE103 UT WOS:A1992HE10300020 ER PT J AU SNODGRASS, HL AF SNODGRASS, HL TI PERMETHRIN TRANSFER FROM TREATED CLOTH TO THE SKIN SURFACE - POTENTIAL FOR EXPOSURE IN HUMANS SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH LA English DT Article ID PERSONAL PROTECTION; ACARI AB Permethrin is an agricultural insecticide of great interest to the military because of its repellency toward disease-bearing insects when impregnated into uniforms. However, migration of the substance from clothing to the skin surface is of toxicological importance. To quantitate leaching from treated clothing, studies were performed in which swatches of fabric impregnated with C-14-labeled permethrin were applied to the backs of rabbits for 1 wk. Permethrin migration was quantitated by measuring the fate of the C-14 label. Conditions that could affect leaching and/or absorption were also evaluated, that is, varying environments, the presence of sweat, different fabric types, and the effects of prelaundering. Results showed that fabric treated with permethrin at a rate of 0.125 mg/cm2 lost the substance to the skin surface at an average rate of 0.49%/d. At the end of the 7-d exposures in rabbits, about 3.2% of the available permethrin had reached the skin, 2% having been recovered from excreta (absorbed) and 1.2% remaining on the skin surface. Prelaundering the treated fabric had little effect on migration rate, nor did the other variables tested. Exposure dose to humans from wearing permethrin-treated (0.125 mg/cm2) military clothing is predicted to be 6 x 10(-4) mg/kg/d. RP SNODGRASS, HL (reprint author), USA,ENVIRONM HYG AGCY,DIV TOXICOL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 22 TC 40 Z9 40 U1 1 U2 5 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0098-4108 J9 J TOXICOL ENV HEALTH JI J. Toxicol. Environ. Health PD FEB PY 1992 VL 35 IS 2 BP 91 EP 105 PG 15 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA HD585 UT WOS:A1992HD58500002 PM 1542137 ER PT J AU BISHOP, JR MOUL, JW SIHELNIK, SA PEPPAS, DS GORMLEY, TS MCLEOD, DG AF BISHOP, JR MOUL, JW SIHELNIK, SA PEPPAS, DS GORMLEY, TS MCLEOD, DG TI USE OF GLYCOSYLATED HEMOGLOBIN TO IDENTIFY DIABETICS AT HIGH-RISK FOR PENILE PERIPROSTHETIC INFECTIONS SO JOURNAL OF UROLOGY LA English DT Article DE DIABETES-MELLITUS; HEMOGLOBIN-A, GLYCOSYLATED; INFECTION; PENILE PROSTHESIS ID PROSTHESIS SURGERY; COMPLICATIONS; MELLITUS; EXPERIENCE AB We report an 18-month prospective study of 90 patients undergoing penile prosthesis implantation to evaluate a possible cause-and-effect relationship between degree of diabetic control and the risk of infection complicating the operation. Long-term diabetic control was objectively evaluated by measurement of the glycosylated hemoglobin of the patient, which is known to provide an objective value for degree of control for the preceding 60 to 90 days. Of 90 patients 5 (5.5%) had a periprosthetic infection requiring explantation and all infections occurred in the 32 diabetics (36%) in the population (p < 0.009). Of the 32 diabetics 13 (41.1%) were poorly controlled with time as demonstrated by a glycosylated hemoglobin level of greater than 11.5% and 4 of the infections occurred in this group. Of the 19 remaining controlled diabetics (glycosylated hemoglobin level less than 11.5%) only 1 infection occurred. Therefore, infection occurred in 31% of the poorly controlled versus 5% of the adequately controlled patients (p < 0.0003). Measurement of glycosylated hemoglobin values appears to be a useful tool to evaluate diabetic patients before implantation of a penile prosthesis. Patients with a glycosylated hemoglobin level of 11.5% or greater should be more optimally controlled before undergoing implantation in an effort to avoid infectious complications. C1 WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. NR 31 TC 69 Z9 69 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD FEB PY 1992 VL 147 IS 2 BP 386 EP 388 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA HB782 UT WOS:A1992HB78200019 PM 1732600 ER PT J AU MOUL, JW MAGGIO, MI HARDY, MR HARTMAN, DS AF MOUL, JW MAGGIO, MI HARDY, MR HARTMAN, DS TI RETROAORTIC LEFT RENAL-VEIN IN TESTICULAR CANCER-PATIENT - POTENTIAL STAGING AND TREATMENT PITFALL SO JOURNAL OF UROLOGY LA English DT Article DE TESTICULAR NEOPLASMS; RENAL VEINS; MAGNETIC RESONANCE IMAGING; TOMOGRAPHY, X-RAY COMPUTED; NEOPLASM STAGING ID ABDOMINAL AORTIC SURGERY; TESTIS CANCER; METASTASES; ANOMALIES AB A 20-year-old man was diagnosed with a left mixed germ cell testicular tumor and clinical staging with computerized tomography suggested left para-aortic subhilar retroperitoneal adenopathy. The patient received 4 cycles of cisplatin, vinblastine and bleomycin chemotherapy but the mass in the left renal hilus area remained unchanged. Subsequent retroperitoneal lymphadenectomy revealed the mass to be a retroaortic left renal vein type 2. Further confusion occurred during followup in differentiating this anomaly from recurrent neoplasm necessitating evaluation by magnetic resonance imaging. Retroaortic left renal vein represents a potential imaging pitfall in testicular cancer that may facilitate suboptimal staging, treatment and followup. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. RP MOUL, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,ROOM A3019,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 20 TC 9 Z9 9 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD FEB PY 1992 VL 147 IS 2 BP 454 EP 456 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA HB782 UT WOS:A1992HB78200041 PM 1310124 ER PT J AU EDWARDS, JSA ROBERTS, DE MUTTER, SH AF EDWARDS, JSA ROBERTS, DE MUTTER, SH TI RATIONS FOR USE IN A COLD ENVIRONMENT SO JOURNAL OF WILDERNESS MEDICINE LA English DT Article DE HYDRATION; MEAL, READY-TO-EAT; RATION; COLD WEATHER; NUTRITION AB This study compares the nutritional support provided by two military field rations, one containing primarily fully reconstituted (wet pack), ready to eat foods items and one containing all dried food items, in an arctic environment. The subjects (n = 80 per group) were soldiers in two companies of light infantry involved in an 8-day winter field exercise in Alaska. Each group was issued approximately 4600 kcal daily. Measurements included food and water intake, food preference ratings of individual food items, and the subjects' hydration status. Mean caloric intakes were 2729 kcal for the group consuming the wet pack foods (MRE/supp) and 2943 kcal for the group consuming dried foods (RCW). Mean weight losses were 2.8 lb (1.6%) and 2.9 lb (1.7%), respectively. Mean daily water intake was 3.4 liters per day for the MRE/supp group and 3.7 liters per day for the RCW group. The mean urine specific gravities were 1.020 for the MRE/supp group and 1.021 for the RCW group, indicating adequate hydration. We conclude that both rations were similar in terms of caloric intake and ability to maintain hydration status. The MRE received slightly higher food preference ratings, but neither experimental group consumed sufficient calories to meet the Military Recommended Dietary Allowances (MRDA) and maintain body weight. Choice of rations should be based not on nutritional criteria, but on consideration such as water availability, size and volume of load, resupply schedule, financial and logistical considerations, and the task at hand. C1 USA,INST ENVIRONM MED,DIV COLD RES,NATICK,MA 01760. NR 0 TC 2 Z9 2 U1 1 U2 2 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0953-9859 J9 J WILDERNESS MED PD FEB PY 1992 VL 3 IS 1 BP 27 EP 47 DI 10.1580/0953-9859-3.1.27 PG 21 WC Medicine, General & Internal; Physiology SC General & Internal Medicine; Physiology GA HD363 UT WOS:A1992HD36300005 ER PT J AU WILTSE, JC MINK, JW AF WILTSE, JC MINK, JW TI QUASI-OPTICAL POWER COMBINING OF SOLID-STATE SOURCES SO MICROWAVE JOURNAL LA English DT Article ID INTERINJECTION-LOCKED OSCILLATORS; INTEGRATED PHASED-ARRAYS; MILLIMETER; CAVITY AB There is a strong need for high power, solid-state sources at microwave and mm-wavelengths. At microwave frequencies, waveguide or cavity combiners have been successful, but at mm-wavelengths this approach has problems in terms of losses, power output and dimensional tolerances. In the past few years, significant efforts have been carried out to develop planar arrays of solid-state oscillators or amplifiers in a grid configuration in order to produce spatial combining. Some of these structures have used open Fabry-Perot resonators for coupling the sources to provide feedback for phase locking. Sources utilized have included Gunn or IMPATT diodes, or FETs or HEMTs with the three-terminal devices currently being more popular. This article discusses these developments and describes the current state of the art. C1 USA,RES OFF,DIV ELECTR,RES TRIANGLE PK,NC. RP WILTSE, JC (reprint author), GEORGIA TECH RES INST,ATLANTA,GA 30322, USA. NR 46 TC 13 Z9 13 U1 1 U2 5 PU HORIZON HOUSE-MICROWAVE PI NORWOOD PA 685 CANTON ST, NORWOOD, MA 02062 SN 0192-6225 J9 MICROWAVE J JI Microw. J. PD FEB PY 1992 VL 35 IS 2 BP 144 EP & PG 0 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA HE835 UT WOS:A1992HE83500009 ER PT J AU KNAPIK, J REYNOLDS, K STAAB, J VOGEL, JA JONES, B AF KNAPIK, J REYNOLDS, K STAAB, J VOGEL, JA JONES, B TI INJURIES ASSOCIATED WITH STRENUOUS ROAD MARCHING SO MILITARY MEDICINE LA English DT Article AB Injuries were recorded during and up to 12 days after a maximal effort road march. Light infantry soldiers (N = 335) carried a total load of 46 kg over a 20 km course. Twenty-four percent of the soldiers suffered one or more injuries, resulting in 44 days of limited duty. All injuries involved the lower extremities and/or the back. Foot blisters and back problems were the most common complaints (35% and 23%, respectively, of the total injuries). These data indicate that units without recent road marching training can expect a high incidence of injuries as a result of a single demanding road march. RP KNAPIK, J (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT MED,NATICK,MA 01760, USA. NR 0 TC 51 Z9 55 U1 0 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1992 VL 157 IS 2 BP 64 EP 67 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA HC531 UT WOS:A1992HC53100009 PM 1603388 ER PT J AU WITHERS, BG KELLEY, PW MCNEIL, JG COWAN, DN BRUNDAGE, JF AF WITHERS, BG KELLEY, PW MCNEIL, JG COWAN, DN BRUNDAGE, JF TI A BRIEF REVIEW OF THE EPIDEMIOLOGY OF HIV IN THE UNITED-STATES-ARMY SO MILITARY MEDICINE LA English DT Article AB The Department of Defense has conducted extensive HIV testing for over 5 years. We summarize the epidemiology of the HIV infection in the total Army. While screening of civilian applicants effectively ensures seronegativity of enlistees, there are approximately 220 new HIV infections each year among active duty soldiers. High-risk demographic groups in the Army include single soldiers, males, those age 25-35, blacks, and Hispanics (including black and Hispanic females). While preventive efforts in the Army should reflect the higher risk experienced by these groups, all soldiers should be made aware of their susceptibility as the epidemic evolves to include more women and heterosexual men. RP WITHERS, BG (reprint author), WALTER REED ARMY MED CTR,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1992 VL 157 IS 2 BP 80 EP 84 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA HC531 UT WOS:A1992HC53100013 PM 1603392 ER PT J AU ROSEN, LN BAIN, MW MOGHADAM, LZ AF ROSEN, LN BAIN, MW MOGHADAM, LZ TI HEALTH-PROBLEMS AMONG ARMY CHILDREN SO MILITARY MEDICINE LA English DT Article AB Of 782 Army families with children that were surveyed, over 10% reported one or more member with health problems or handicapping conditions requiring special ongoing treatment. However, less than half of these were enrolled in the Exceptional Family Member Program. Families with illnesses/handicaps that were enrolled in the program reported on the average more health problems than families with illnesses that were not enrolled. RP ROSEN, LN (reprint author), WALTER REED ARMY MED CTR,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 1 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1992 VL 157 IS 2 BP 85 EP 88 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA HC531 UT WOS:A1992HC53100014 PM 1376460 ER PT J AU RITCHIE, EC AF RITCHIE, EC TI TREATMENT OF GAS MASK PHOBIA SO MILITARY MEDICINE LA English DT Article AB Many soldiers develop feelings of claustrophobia when wearing a protective mask. In the battlefield environment of today, it is essential that soldiers be able to tolerate gas masks. This article briefly reviews the historical use of gas masks in the U.S. Army. Two cases of treatment of gas mask phobia are described. Behavioral therapy techniques useful for treatment are summarized. RP RITCHIE, EC (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1992 VL 157 IS 2 BP 104 EP 106 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA HC531 UT WOS:A1992HC53100019 PM 1603385 ER PT J AU OMEARA, NT SOLAND, RM AF OMEARA, NT SOLAND, RM TI OPTIMAL STRATEGIES FOR PROBLEMS OF SIMULTANEOUS ATTACK AGAINST AN AREA DEFENSE WITH IMPACT-POINT PREDICTION SO NAVAL RESEARCH LOGISTICS LA English DT Article ID PREALLOCATED PREFERENTIAL DEFENSE AB An area to be defended consists of separated point targets. These targets are subject to an attack in which the offensive weapons are assumed to arrive simultaneously. The defense has area defenders, each of which is capable of intercepting any attacker Furthermore, the defense has impact-point prediction, i.e., it has knowledge of each attacker's intended target prior to allocation of the area interceptors. For a given attack, the defense wishes to allocate its interceptors against attackers so as to maximize the expected total survival value of the targets. In its first move, the offense seeks an attack allocation which will minimize expected total surviving value against best defense. We develop an algorithm to determine optimal attack and defense strategies and the optimal value of this sequential min-max problem. Branch-and-bound techniques are used to obtain integer solutions, and illustrative computational results are provided. C1 GEORGE WASHINGTON UNIV,SCH ENGN & APPL SCI,DEPT OPERAT RES,WASHINGTON,DC 20052. RP OMEARA, NT (reprint author), USA,STRATEG DEF COMMAND,ARLINGTON,VA 22215, USA. NR 22 TC 7 Z9 8 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD FEB PY 1992 VL 39 IS 1 BP 1 EP 28 PG 28 WC Operations Research & Management Science SC Operations Research & Management Science GA GZ947 UT WOS:A1992GZ94700001 ER PT J AU KRUMINS, SA BROOMFIELD, CA AF KRUMINS, SA BROOMFIELD, CA TI EVIDENCE OF NK1 AND NK2 TACHYKININ RECEPTORS AND THEIR INVOLVEMENT IN HISTAMINE-RELEASE IN A MURINE MAST-CELL LINE SO NEUROPEPTIDES LA English DT Article ID SUBSTANCE-P ANTAGONIST; SWISS 3T3 CELLS; SELECTIVE AGONISTS; INDEPENDENT MODE; HUMAN-SKIN; RAT; PEPTIDES; BINDING; ACTIVATION; SUBSTANCE-P AB Binding of [H-3]substance P (SP) and histamine release were examined using a cloned mouse mast cell line. SP binding was saturable and specific. In the presence of 30 mM Na2SO4/50 mM Tris buffer, SP interacted with two types of binding sites K(d) values of 0.3 and 40 nM. High-affinity SP binding was blocked by the inclusion of 0.5 uM of the NK1 receptor selective ligand septide in the binding mixture. Neurokinin A (NKA) evoked concentration-dependent histamine release. At concentrations in the nanomolar range, the NK1 preferring agonists SP, SP methylester and physalaemin evoked less-than-or-equal-to 5% net release of histamine, which was substantially less than the maximum effect of NKA (+37%) in the micromolar range. Pretreatment of the cells with the NK2 antagonist peptide A reduced NKA-induced histamine release. [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P, a putative SP antagonist, also elicited histamine release in the micromolar range, apparently acting as an agonist at the NK2 site. Compound 48/80, N-terminal SP fragments, neurokinin B and the two selective NK2 receptor antagonists cyclo(Gln-Trp-Phe-(R)-[ANC-2]Leu-Met) (peptide A) and cyclo(Gln-Trp-Phe-Gly-Leu-Met) (peptide B) were ineffective. Although the results suggest the coexistence of functional NK1 and NK2 receptors, it appears that in this mast cell line neurokinin-induced histamine release is primarily mediated by the NK2 receptor, characterized biochemically as a low affinity binding site with a K(d) value of 40nM for SP. C1 USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 40 TC 50 Z9 52 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH, MIDLOTHIAN, SCOTLAND EH1 3AF SN 0143-4179 J9 NEUROPEPTIDES JI Neuropeptides PD FEB PY 1992 VL 21 IS 2 BP 65 EP 72 DI 10.1016/0143-4179(92)90516-Y PG 8 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA HE569 UT WOS:A1992HE56900001 PM 1372967 ER PT J AU HERZWURM, PJ WALSH, J PETTINE, KA EBERT, FR AF HERZWURM, PJ WALSH, J PETTINE, KA EBERT, FR TI PROPHYLACTIC CERCLAGE - A METHOD OF PREVENTING FEMUR FRACTURE IN UNCEMENTED TOTAL HIP-ARTHROPLASTY SO ORTHOPEDICS LA English DT Article AB The incidence of femur fracture in noncemented hip arthroplasty has been reported to be between 4.1 % and 27.8 %. To quantitate the hoop stress generated during insertion of a femoral broach in total hip arthroplasty and determine the effect of cerclage with both braided cable and wire, we harvested 14 pairs of embalmed cadaver femurs. These were reamed and broached to duplicate the surgical technique of inserting a straight non-cemented femoral component. Group one consisted of eight matched cadaver femurs which were tested using a single 2.0 mm chrome-cobalt cable placed around the calcar of one femur, with the other serving as a control. Group two consisted of five matched cadaver femurs which were tested using a single 18 gauge cerclage wire in the same manner. In group one, the femurs serving as controls were found to have a mean microstrain of (1425.00 +/- 1180.19). The eight femurs tested with a 2 mm cable were determined to have a mean microstrain of (4179 +/- 2853.89). In group two, the femurs serving as controls were found to have a mean microstrain of (962.60 +/- 956.78). The five femurs in group two tested with a cerclage wire were determined to have a mean microstrain of (1112.00 +/- 975.66). Using a paired t-test, statistical significance was achieved with a confidence level of P less-than-or-equal-to .01 in group one. Prophylactic wiring of the proximal femur with 2 mm cable increases the hoop stress resistance and, therefore, should decrease the incidence of intraoperative femur fractures in uncemented total hip arthroplasty. RP HERZWURM, PJ (reprint author), EISENHOWER ARMY MED CTR,ORTHOPAED SURG SERV,FT GORDON,GA 30905, USA. NR 0 TC 26 Z9 27 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD FEB PY 1992 VL 15 IS 2 BP 143 EP 146 PG 4 WC Orthopedics SC Orthopedics GA HC660 UT WOS:A1992HC66000004 PM 1738716 ER PT J AU WEISSE, ME BASS, JW YOUNG, LM AF WEISSE, ME BASS, JW YOUNG, LM TI PEDIATRIC BLOOD CULTURE - COMPARISON OF YIELDS USING AEROBIC, ANAEROBIC AND HYPERTONIC MEDIA SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Note DE BLOOD CULTURE; BACTEC; PEDIATRIC; CHILD ID HEMOPHILUS-INFLUENZAE; RADIOMETRIC DETECTION; BACTEREMIA C1 TRIPLER ARMY MED CTR,DEPT PEDIAT PATHOL,HONOLULU,HI 96859. NR 7 TC 5 Z9 5 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD FEB PY 1992 VL 11 IS 2 BP 123 EP 125 PG 3 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA HD422 UT WOS:A1992HD42200014 PM 1741183 ER PT J AU BASS, JW AF BASS, JW TI TREATMENT OF SKIN AND SKIN STRUCTURE INFECTIONS SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE SKIN INFECTIONS; STAPHYLOCOCCUS-AUREUS; TOXIC SHOCK SYNDROME; SCALDED SKIN SYNDROME ID TOXIC-SHOCK SYNDROME; STREPTOCOCCUS-PYOGENES; SCARLET FEVER; ASSOCIATION; CELLULITIS; DISEASE RP BASS, JW (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. NR 27 TC 4 Z9 4 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD FEB PY 1992 VL 11 IS 2 BP 152 EP 155 DI 10.1097/00006454-199202000-00032 PG 4 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA HD422 UT WOS:A1992HD42200026 PM 1741194 ER PT J AU WISWELL, TE HENLEY, MA AF WISWELL, TE HENLEY, MA TI INTRATRACHEAL SUCTIONING, SYSTEMIC INFECTION, AND THE MECONIUM ASPIRATION SYNDROME SO PEDIATRICS LA English DT Article DE MECONIUM ASPIRATION SYNDROME; ASPHYXIA NEONATORUM; INTRATRACHEAL SUCTIONING; INTUBATION; EXTRACORPOREAL MEMBRANE OXYGENATION ID TRACHEAL SUCTION; STAINED NEONATE; MANAGEMENT; NEWBORN; INFANTS AB A retrospective analysis was performed to determine: (1) the proportion of neonates with the meconium aspiration syndrome (MAS) who were not depressed at birth; (2) to evaluate the clinical course of neonates with MAS, particularly relating to whether or not delivery room intubation and intratracheal suctioning had taken place; and (3) to examine the incidence of culture-proven bacteremia among meconium-stained neonates and those with MAS. The medical records of all meconium-stained neonates and those with MAS admitted to our facility from 1985 through 1989 were reviewed. Of 5697 liveborn neonates, 741 (13%) were meconium-stained, of whom 608 (82%) were intubated and suctioned in the delivery room. No complications of the intubation/suctioning procedure were noted in these neonates. Forty-five neonates had culture-proven bacteremia. Five bacteremic neonates had been meconium-stained (0.7% of all such neonates), while 40 were not stained (0.8% incidence). Of 36 neonates with MAS, 1 (2.8%) was bacteremic. Twenty (56%) of 36 newborns with MAS did not require positive pressure ventilation in the delivery room. Twelve (33%) of the babies with MAS had not been intubated and suctioned in the delivery room. Nine (75%) of 12 nonsuctioned neonates, as well as 6 (25%) of 24 suctioned neonates, required mechanical ventilation for more than 6 hours (P = .010). Pneumothoraces occurred in 6 (50%) of 12 nonsuctioned and 5 (21%) of 24 suctioned babies (P = .125). Four of 12 nonsuctioned newborns either died (n = 1) or required extracorporeal membrane oxygenation (n = 3), while only 1 of the suctioned newborns required extracorporeal membrane oxygenation (P = .034). It is concluded that (1) delivery room intubation of meconium-stained neonates appears to be a procedure with a low incidence of complications; (2) a substantial proportion of neonates in whom MAS subsequently develops do not require resuscitation at birth; (3) neonates who develop MAS after not having been suctioned may be at increased risk for adverse sequelae; and (4) there is no evidence for an increased incidence of bacteremia among meconium-stained neonates. C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,NEONATOL SERV,WASHINGTON,DC 20307. NR 33 TC 60 Z9 60 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD FEB PY 1992 VL 89 IS 2 BP 203 EP 206 PG 4 WC Pediatrics SC Pediatrics GA HD255 UT WOS:A1992HD25500005 PM 1734384 ER PT J AU WITKIN, JM GENOVESE, RF WITKIN, KM CHIANG, PK AF WITKIN, JM GENOVESE, RF WITKIN, KM CHIANG, PK TI BEHAVIORAL-EFFECTS OF SOME DIPHENYL-SUBSTITUTED ANTIMUSCARINICS - COMPARISON WITH COCAINE AND ATROPINE SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE ATROPINE; BENACTYZINE; AZAPROPHEN; COCAINE; LOCOMOTOR ACTIVITY; FIXED-INTERVAL SCHEDULES; DISCRIMINATIVE STIMULUS EFFECTS; BEHAVIORAL EFFECTS; RATS ID SCHEDULE-CONTROLLED BEHAVIOR; SQUIRREL-MONKEY; DOPAMINE UPTAKE; AZAPROPHEN; PHYSOSTIGMINE; PHARMACOLOGY; ANTAGONISTS; SCOPOLAMINE; INHIBITORS; AGENTS AB To more fully characterize the behavioral excitatory effects observed with certain diphenyl-substituted antimuscarinics, various behavioral effects of benactyzine, a prototype excitatory antimuscarinic, was evaluated in rats. These effects were compared to those of cocaine, atropine, and azaprophen, a muscarinic antagonist that contains both the diphenyl substituents of benactyzine and a ring isomeric with the tropane ring of atropine. Under a fixed-interval 5-min schedule of food presentation, cocaine and benactyzine increased response rates. Atropine and azaprophen only decreased responding. The muscarinic agonist oxotremorine attenuated the rate-increasing effects but did not alter the disruptions in the temporal patterning produced by benactyzine or shift the dose-effect function to the right. In rats discriminating 10 mg/kg cocaine from saline, benactyzine partially substituted for cocaine, producing a maximum of 50% cocaine-appropriate responses. Benactyzine fully substituted for scopolamine in rats discriminating 0.056 mg/kg scopolamine from saline. All antimuscarinics increased locomotor activity when activity levels were low in control animals, but the increases were less than those produced by cocaine. Cocaine increased both locomotor activity and fixed-interval responding at comparable doses, whereas 10-fold higher doses of benactyzine were required to increase locomotor activity. These results support the following conclusions: 1) In addition to its classical antimuscarinic behavioral profile, benactyzine has behavioral excitatory actions similar in some respects to those of cocaine; 2) the behavioral excitatory effects of benactyzine do not appear to be due solely to antagonism of muscarinic receptors; and 3) the alkyl-ester may be an important structural feature of diphenyl-substituted antimuscarinics for the induction of behavioral stimulation. C1 WEINBERG CONSULTING GRP INC,WASHINGTON,DC 20036. WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT APPL BIOCHEM,WASHINGTON,DC 20307. RP WITKIN, JM (reprint author), NIDA,ADDICT RES CTR,PSYCHOBIOL LAB,DRUG DEV GRP,POB 5180,BALTIMORE,MD 21224, USA. NR 27 TC 5 Z9 5 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD FEB PY 1992 VL 41 IS 2 BP 377 EP 384 DI 10.1016/0091-3057(92)90114-U PG 8 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA HM764 UT WOS:A1992HM76400019 PM 1574528 ER PT J AU SHURTLEFF, D RASLEAR, TG GENOVESE, RF SIMMONS, L AF SHURTLEFF, D RASLEAR, TG GENOVESE, RF SIMMONS, L TI PERCEPTUAL BISECTION IN RATS - THE EFFECTS OF PHYSOSTIGMINE, SCOPOLAMINE AND PIRENZEPINE SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE PHYSOSTIGMINE; PIRENZEPINE; SCOPOLAMINE; CHOLINERGIC; TEMPORAL DISCRIMINATION; LOUDNESS DISCRIMINATION; RATS ID DIISOPROPYL PHOSPHOROFLUORIDATE DFP; TIME PERCEPTION; INTERNAL CLOCK; DISCRIMINATION; PATTERNS; MODELS; BIAS; LAW AB The effects of cholinergic drugs on three different perceptual bisection tasks were studied in rats. Physostigmine (0.056-0.56 mg/kg), a reversible anticholinesterase, produced dose-dependent decrements in discriminability (A'), but did not affect the bisection point (BP) in visual duration, auditory duration, and auditory intensity bisection tasks. This finding is consistent with results previously obtained in an auditory duration bisection task with an irreversible anticholinesterase, diisopropyl phosphorfluoridate. Scopolamine (0.075-0.422 mg/kg), a muscarinic cholinergic-receptor antagonist, produced dose-dependent decrements in both A' and BP in visual and auditory duration bisection tasks. The behavioral antagonism between physostigmine (0.56 mg/kg) and scopolamine (0.075-0.237 mg/kg) was studied in the visual and auditory duration bisection tasks. The BP was not affected by physostigmine alone or in combination with scopolamine, except at the largest dose of scopolamine, which produced a reliable decrement in the BP. A', however, was equally decreased by physostigmine alone and all combinations of physostigmine and scopolamine. Pirenzepine (1, 3 and 10 mg/kg), a selective high-affinity M1 muscarinic antagonist, had no effect on A' or the BP in the duration bisection tasks, suggesting changes in perception produced by muscarinic antagonists do not involve the M1 receptor subtype. The similar drug effects in different sensory modalities (visual and auditory) and perceptual systems (subjective duration and loudness) suggest that cholinergic drugs may affect perceptual mechanisms responsible for sensory coding, such as the output of a neural generator. C1 WALTER REED ARMY MED CTR,DEPT MICROWAVE RES,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307. RP SHURTLEFF, D (reprint author), USN,MED RES INST,THERMAL STRESS ADAPTAT PROGRAM,MS-11,BETHESDA,MD 20889, USA. NR 33 TC 20 Z9 20 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD FEB PY 1992 VL 51 IS 2 BP 381 EP 390 DI 10.1016/0031-9384(92)90156-V PG 10 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA HA082 UT WOS:A1992HA08200024 PM 1557449 ER PT J AU ALVING, CR VERMA, JN RAO, M KRZYCH, U AMSELEM, S GREEN, SM WASSEF, NM AF ALVING, CR VERMA, JN RAO, M KRZYCH, U AMSELEM, S GREEN, SM WASSEF, NM TI LIPOSOMES CONTAINING LIPID-A AS A POTENT NONTOXIC ADJUVANT SO RESEARCH IN IMMUNOLOGY LA English DT Article ID MALARIA SPOROZOITE ANTIGEN; ALUMINUM HYDROXIDE; MACROPHAGES; LIPOPOLYSACCHARIDE; ENDOTOXIN; LPS C1 WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. RP ALVING, CR (reprint author), WALTER REED ARMY MED CTR,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307, USA. NR 12 TC 21 Z9 21 U1 0 U2 0 PU EDITIONS SCIENTIFIQUES ELSEVIER PI PARIS CEDEX 15 PA 141 RUE JAVEL, 75747 PARIS CEDEX 15, FRANCE SN 0923-2494 J9 RES IMMUNOL JI Res. Immunol. PD FEB PY 1992 VL 143 IS 2 BP 197 EP 198 DI 10.1016/S0923-2494(92)80165-H PG 2 WC Immunology SC Immunology GA HH607 UT WOS:A1992HH60700010 PM 1574647 ER PT J AU GREGORIADIS, G SZOKA, FC HARDING, CV HUANG, L ALVING, CR VERMA, JN RAO, M KRZYCH, U AMSELEM, S GREEN, SJ WASSEF FIDLER, IJ PHILLIPS, NC DAEMEN, T BOGERS, W BERKENBOSCH, F DERIJK, RH CLAASSEN, E PATEL, H AF GREGORIADIS, G SZOKA, FC HARDING, CV HUANG, L ALVING, CR VERMA, JN RAO, M KRZYCH, U AMSELEM, S GREEN, SJ WASSEF FIDLER, IJ PHILLIPS, NC DAEMEN, T BOGERS, W BERKENBOSCH, F DERIJK, RH CLAASSEN, E PATEL, H TI LIPOSOMES AS AN INVIVO TOOL TO STUDY AND MANIPULATE MACROPHAGE FUNCTION - DISCUSSION SO RESEARCH IN IMMUNOLOGY LA English DT Discussion DE LIPOSOME; MACROPHAGE; TUMOR; LYMPHOCYTE; IMMUNOREGULATION; MHC; LIVER; ENDOTOXIN; MDP; AUTOIMMUNITY; LIPIDS; IMMUNOTHERAPY; FORUM ID MURAMYL TRIPEPTIDE PHOSPHATIDYLETHANOLAMINE; PROLONGED CIRCULATION TIME; MANNOSYLATED LIPOSOMES; ANTITUMORAL PROPERTIES; REDUCED TOXICITY; ENHANCED UPTAKE; PHASE-I; LPS; INTERLEUKIN-1; FORMULATIONS C1 UNIV CALIF SAN FRANCISCO,DEPT PHARM & PHARMACEUT CHEM,SAN FRANCISCO,CA 94143. WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110. UNIV PITTSBURGH,SCH MED,DEPT PHARMACOL,PITTSBURGH,PA 15261. WALTER REED ARMY MED CTR,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT CELL BIOL,HOUSTON,TX 77030. MCGILL UNIV,MONTREAL GEN HOSP,RES INST,MONTREAL H3G 1A4,QUEBEC,CANADA. MCGILL UNIV,MONTREAL H3A 2T5,QUEBEC,CANADA. UNIV GRONINGEN,PHYSIOL CHEM LAB,9712 KZ GRONINGEN,NETHERLANDS. FREE UNIV AMSTERDAM,DEPT ADULT PSYCHIAT,DIV HISTOL,1081 BT AMSTERDAM,NETHERLANDS. UNIV HOSP LEIDEN,DEPT NEPHROL,2300 RC LEIDEN,NETHERLANDS. TNO,MED BIOL LAB,DEPT IMMUNOL & MED MICROBIOL,2280 AA RIJSWIJK,NETHERLANDS. CHARING CROSS & WESTMINSTER MED SCH,DEPT BIOCHEM,LONDON W6 8RF,ENGLAND. RP GREGORIADIS, G (reprint author), UNIV LONDON,SCH PHARM,CTR DRUG DELIVERY RES,29-39 BRUNSWICK SQ,LONDON WC1N 1AX,ENGLAND. NR 32 TC 0 Z9 0 U1 0 U2 1 PU EDITIONS SCIENTIFIQUES ELSEVIER PI PARIS CEDEX 15 PA 141 RUE JAVEL, 75747 PARIS CEDEX 15, FRANCE SN 0923-2494 J9 RES IMMUNOL JI Res. Immunol. PD FEB PY 1992 VL 143 IS 2 BP 245 EP 256 PG 12 WC Immunology SC Immunology GA HH607 UT WOS:A1992HH60700020 ER PT J AU MEYER, CA KRANSDORF, MJ MOSER, RP JELINEK, JS AF MEYER, CA KRANSDORF, MJ MOSER, RP JELINEK, JS TI CASE-REPORT 716 - SOFT-TISSUE METASTASIS IN SYNOVIAL SARCOMA SO SKELETAL RADIOLOGY LA English DT Note C1 ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT RADIOL,HERSHEY,PA 17033. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. WASHINGTON HOSP CTR,DEPT RADIOL,WASHINGTON,DC 20010. NR 5 TC 10 Z9 10 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-2348 J9 SKELETAL RADIOL JI Skeletal Radiol. PD FEB PY 1992 VL 21 IS 2 BP 128 EP 131 PG 4 WC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging SC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging GA HF936 UT WOS:A1992HF93600010 PM 1314428 ER PT J AU MOLINE, ML POLLAK, CP MONK, TH LESTER, LS WAGNER, DR ZENDELL, SM GRAEBER, RC SALTER, CA HIRSCH, E AF MOLINE, ML POLLAK, CP MONK, TH LESTER, LS WAGNER, DR ZENDELL, SM GRAEBER, RC SALTER, CA HIRSCH, E TI AGE-RELATED DIFFERENCES IN RECOVERY FROM SIMULATED JET-LAG SO SLEEP LA English DT Article DE JET LAG; SLEEP; CIRCADIAN RHYTHMS; AGING ID SLOW-WAVE SLEEP; INDIVIDUAL-DIFFERENCES; CIRCADIAN-RHYTHM; SHIFT-WORK; REM-SLEEP; PERFORMANCE; TEMPERATURE; DEPRIVATION; INSOMNIACS; CYCLE AB Six healthy young men and eight early middle-aged men were isolated from environmental time cues for 15 days. For the first 6-7 days (one or two nights adaptation, four nights baseline), their sleep and meals were scheduled to approximate their habitual patterns. Their daily routines were then shifted 6 hours earlier by terminating the sixth or seventh sleep episode 6 hours early. The new schedules were followed for the next 8 or 9 days. Important age-related differences in adjustment to this single 6-hour schedule shift were found. For the first 4-day interval after the shift, middle-aged subjects had larger increases of waking time during the sleep period and earlier termination of sleep than young subjects. They also reported larger decreases in alertness and well-being and larger increases in sleepiness, weariness and effort required to perform daily functions. The rate of adjustment of the circadian core temperature rhythm to the new schedule did not differ between groups. These results suggest that the symptoms reported by the middle-aged subjects may be due mainly to difficulty maintaining sleep at early times of the circadian day. The compensatory response to sleep deprivation may also be less robust in middle-aged individuals traveling eastbound. C1 WESTERN PSYCHIAT INST & CLIN,PITTSBURGH,PA 15261. NASA,AMES RES CTR,MOFFETT FIELD,CA 94035. USA,NATICK RD&E CTR,NATICK,MA 01760. RP MOLINE, ML (reprint author), NEW YORK HOSP,CORNELL MED CTR,INST CHRONOBIOL,21 BLOOMINGDALE RD,WHITE PLAINS,NY 10605, USA. NR 46 TC 54 Z9 55 U1 0 U2 2 PU AMER SLEEP DISORDERS ASSOC PI ROCHESTER PA 1610 14TH STREET NW SUITE 300, ROCHESTER, MN 55806 SN 0161-8105 J9 SLEEP JI Sleep PD FEB PY 1992 VL 15 IS 1 BP 28 EP 40 PG 13 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA HF940 UT WOS:A1992HF94000004 PM 1557592 ER PT J AU ACKER, CG AF ACKER, CG TI CHOLESTEROL MICROEMBOLIZATION AND STABLE RENAL-FUNCTION WITH CONTINUED ANTICOAGULATION SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID STREPTOKINASE THERAPY; EMBOLIZATION; ANGIOGRAPHY; INFARCTION; DISEASE RP ACKER, CG (reprint author), EISENHOWER ARMY MED CTR,DEPT INTERNAL MED,FT GORDON,GA, USA. NR 14 TC 2 Z9 2 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD FEB PY 1992 VL 85 IS 2 BP 210 EP 212 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA HE866 UT WOS:A1992HE86600024 PM 1738893 ER PT J AU XIONG, YM SNYDER, PG WOOLLAM, JA ALJUMAILY, GA GAGLIARDI, FJ MIZERKA, LJ AF XIONG, YM SNYDER, PG WOOLLAM, JA ALJUMAILY, GA GAGLIARDI, FJ MIZERKA, LJ TI OPTICAL CHARACTERIZATION OF SILICON OXYNITRIDE THIN-FILMS BY VARIABLE ANGLE SPECTROSCOPIC ELLIPSOMETRY SO SURFACE AND INTERFACE ANALYSIS LA English DT Article; Proceedings Paper CT 13TH SYMP ON APPLIED SURFACE ANALYSIS CY JUN 12-14, 1991 CL MINNEAPOLIS, MN ID ION-ASSISTED DEPOSITION; SIH4-CO2-NH3-H-2 SYSTEM; KINETICS; GE AB Silicon oxynitride (SiOxNy) thin films were deposited on silicon substrates by ion-assisted deposition. Variable angle spectroscopic ellipsometry (VASE) was used to optically characterize the deposited film properties, such as layer thickness and composition, film surface and interface qualities, as well as the refractive index spectrum in the wavelength range 320-820 nm. The measured VASE spectra were analyzed by assuming SiOxNy to be a physical mixture of two distinct phases, silicon dioxide and silicon nitride, using the Bruggeman effective medium approximation. Remarkably good agreements between the measured spectra and model calculations were obtained over the entire spectral range for all the samples studied. Layer thicknesses of SiOxNy films determined by VASE were consistent with their corresponding nominal values. The ellipsometrically deduced refractive index spectrum was observed to be strongly dependent on the film composition. In addition, the film refractive index at each applied wavelength was found to be a linear function of its constituent relative volume fraction. The results from VASE analysis also indicated that all the sample films investigated exhibited smooth surfaces, sharp interfaces between the film and substrate and high packing density. C1 UNIV NEBRASKA,DEPT ELECT ENGN,CTR MICROELECTR & OPT MAT RES,LINCOLN,NE 68588. BARR ASSOCIATES INC,WESTFORD,MA 01886. USA,MAT TECHNOL LAB,SLCMT,EMS,WATERTOWN,MA 02172. NR 30 TC 5 Z9 5 U1 0 U2 2 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0142-2421 J9 SURF INTERFACE ANAL JI Surf. Interface Anal. PD FEB PY 1992 VL 18 IS 2 BP 124 EP 128 DI 10.1002/sia.740180211 PG 5 WC Chemistry, Physical SC Chemistry GA HJ670 UT WOS:A1992HJ67000010 ER PT J AU WEINSTEIN, SA BELL, RC BROWN, CR FLETCHER, JE SMITH, LA AF WEINSTEIN, SA BELL, RC BROWN, CR FLETCHER, JE SMITH, LA TI PATHOLOGICAL-CHANGES INDUCED BY PHOSPHOLIPASE-A2 ISOLATED FROM THE VENOM OF COLLETT SNAKE, PSEUDECHIS-COLLETTI - A LIGHT AND ELECTRON-MICROSCOPIC STUDY SO TOXICON LA English DT Article ID NOTECHIS-SCUTATUS-SCUTATUS; AUSTRALIAN TIGER SNAKE; VIRIDIS-VIRIDIS VENOM; RAT SKELETAL-MUSCLE; MYOTOXIN-A; RATTLESNAKE; MYOGLOBINURIA; PURIFICATION; RESPONSES; DAMAGE AB Pseudechis colletti is an Australian elapid snake with a range limited to central Queensland, Australia. The venom of this snake, as well as that of several other Australian elapids, has been shown to contain a phospholipase A2 (PLA2) which can cause a marked myoglobinuria in mice. Few studies have described the histopathologic and ultrastructural changes that result from myotoxic PLA2-induced damage. Our investigation demonstrated that the isolated PLA2 induced myodegeneration and necrosis in myocardium in a dose-related manner, with subsequent myoglobinuria and myoglobinuric nephropathy. C1 USA,MED RES INST INFECT DIS,DEPT TOXINOL,DIV PATHOPHYSIOL,FT DETRICK,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DEPT COMPARAT PATHOL,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DEPT ELECTRON MICROSCOPY,FREDERICK,MD 21701. HAHNEMANN UNIV,DEPT ANESTHESIOL,PHILADELPHIA,PA 19102. NR 46 TC 17 Z9 17 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD FEB PY 1992 VL 30 IS 2 BP 171 EP 185 DI 10.1016/0041-0101(92)90470-P PG 15 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA HK584 UT WOS:A1992HK58400007 PM 1557787 ER PT J AU HOOTEN, ME FINSTUEN, K THOMPSON, IM AF HOOTEN, ME FINSTUEN, K THOMPSON, IM TI MULTIVARIATE CASE-CONTROL STUDY OF SURVIVAL FOLLOWING TRANSURETHRAL RESECTION OF PROSTATE SO UROLOGY LA English DT Article ID HYPERPLASIA; REOPERATION; MORTALITY AB Although prevalence of perioperative mortality following transurethral resection of the prostate (TURP) has steadily declined as reported in several review studies, it has been suggested that with extended follow-up after TURP, mortality exceeds that of an age-matched population. The sample selected for this study was drawn from a data base of 2,005 men who entered a urologic health-screening program. The sample included a group of 25 patients who underwent TURP and a group of 50 age-matched control patients with symptoms of prostatism. Patients were followed for six years, a total of 450 observed person-years. Multivariate analyses based on a general linear model approach for the dependent variable of survival were used to assess gains in predictive efficiency due to combinations of TURP versus control, time, and patient variables. F-ratio hypothesis tests of coefficients of multiple determination for the models indicated that TURP did account for a significant amount of the variability of survival but only after five years of follow-up. However, a far larger proportion of the variance in survival was explained by other patient variables of age, preoperative risk, comorbidity factors, and postoperative urinary disease after all effects due to TURP, follow-up years, and operation cohort years were held constant in the survival prediction equation. C1 BROOKE ARMY MED CTR,UROL SERV,FT SAM HOUSTON,TX 78234. BAYLOR UNIV,GRAD SCH,USA,HLTH CARE ADM PROGRAM,WACO,TX 76798. NR 16 TC 5 Z9 5 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD FEB PY 1992 VL 39 IS 2 BP 111 EP 116 DI 10.1016/0090-4295(92)90265-X PG 6 WC Urology & Nephrology SC Urology & Nephrology GA HD891 UT WOS:A1992HD89100003 PM 1736501 ER PT J AU DIAZ, JM SMITH, KG MACCARIO, M AF DIAZ, JM SMITH, KG MACCARIO, M TI EXACERBATION OF MOTOR TIC AND INDUCTION OF NEW TIC BY HALOPERIDOL USE SO WESTERN JOURNAL OF MEDICINE LA English DT Article ID NERVOUS-SYSTEM STIMULANTS; TOURETTE-LIKE SYNDROME; NEUROLEPTIC TREATMENT; DISORDER; LINKAGE C1 UNIV CALIF SAN FRANCISCO,DEPT EPIDEMIOL & BIOSTAT,SAN FRANCISCO,CA 94143. LETTERMAN ARMY MED CTR,DEPT MED,NEUROL SERV,SAN FRANCISCO,CA 94129. RP DIAZ, JM (reprint author), WILLIAM BEAUMONT ARMY MED CTR,DEPT MED,NEUROL SERV,FT BLISS,TX 79920, USA. NR 24 TC 2 Z9 2 U1 0 U2 0 PU CARDEN JENNINGS PUBL CO LTD PI CHARLOTTESVILLE PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903 SN 0093-0415 J9 WESTERN J MED JI West. J. Med. PD FEB PY 1992 VL 156 IS 2 BP 198 EP 199 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA HD714 UT WOS:A1992HD71400019 PM 1536082 ER PT J AU REDFIELD, RR BIRX, DL TRAMONT, EC BURKE, DS AF REDFIELD, RR BIRX, DL TRAMONT, EC BURKE, DS TI VACCINATION WITH GP160 IN HIV - REPLY SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 MARYLAND BIOTECHNOL INST,BALTIMORE,MD 21201. RP REDFIELD, RR (reprint author), WALTER REED ARMY MED CTR,ROCKVILLE,MD 20850, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JAN 30 PY 1992 VL 326 IS 5 BP 348 EP 348 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA HA991 UT WOS:A1992HA99100024 ER PT J AU SHAW, RW AF SHAW, RW TI SUPERCRITICAL WATER - REPLY SO CHEMICAL & ENGINEERING NEWS LA English DT Letter C1 USA,WASHINGTON,DC 20310. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0009-2347 J9 CHEM ENG NEWS JI Chem. Eng. News PD JAN 27 PY 1992 VL 70 IS 4 BP 3 EP 3 PG 1 WC Chemistry, Multidisciplinary; Engineering, Chemical SC Chemistry; Engineering GA HB115 UT WOS:A1992HB11500004 ER PT J AU MALEVSKY, AV YUEN, DA WEYER, LM AF MALEVSKY, AV YUEN, DA WEYER, LM TI VISCOSITY AND THERMAL FIELDS ASSOCIATED WITH STRONGLY CHAOTIC NON-NEWTONIAN THERMAL-CONVECTION SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID TURBULENCE; MANTLE AB We have investigated the thermomechanical structure in strongly chaotic non-Newtonian thermal convection for both base-heated and internally-heated systems. Temperature can build up in stagnant regions and a non-Newtonian mantle can tolerate less internal-heating. Viscosity fields of strongly chaotic regime show a granular structure. The horizontal spectra of viscosity fluctuations obey a power-law and yield a fractal dimension of 1. 6 to 1. 8 for the isoviscosity lines, providing evidence for two-dimensional turbulence. Long wavelength viscosity variations are smoothed out by the turbulent non-Newtonian flows. C1 UNIV MINNESOTA,DEPT GEOL & GEOPHYS,MINNEAPOLIS,MN 55455. RP MALEVSKY, AV (reprint author), UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP & RES CTR,MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55415, USA. NR 10 TC 12 Z9 14 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD JAN 24 PY 1992 VL 19 IS 2 BP 127 EP 130 DI 10.1029/91GL03181 PG 4 WC Geosciences, Multidisciplinary SC Geology GA HC057 UT WOS:A1992HC05700013 ER PT J AU CARR, ME KRISHNAMURTI, C ALVING, BM AF CARR, ME KRISHNAMURTI, C ALVING, BM TI EFFECT OF PLASMINOGEN-ACTIVATOR INHIBITOR-1 ON TISSUE-TYPE PLASMINOGEN ACTIVATOR-INDUCED FIBRINOLYSIS SO THROMBOSIS AND HAEMOSTASIS LA English DT Article ID FAST-ACTING INHIBITOR; HYPOTHERMIA; PLASMA; PAI-1 AB The effect of fibrin on the interaction of human recombinant single-chain tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) was studied in normal rabbit plasma and in plasma with high levels of native PAI-1. t-PA was added to diluted plasma containing calcium (10 mM) and I-125-fibrinogen at 37-degrees-C. Clotting was initiated with human thrombin, and lysis was monitored both turbidimetrically and by release of I-125-fibrin degradation products (fdp). The activity of t-PA (50 IU/ml) was rapidly reduced to 15% of the initial value in plasma containing PAI-1 (23 AU/ml). When thrombin and t-PA were added simultaneously to the plasma, more than 70% of the activity was retained through incorporation of t-PA into the fibrin clot. t-PA-induced fibrinolysis in PAI-I enriched plasma was further delayed when the temperature was reduced from 37 to 25-degrees-C. Turbidimetric and I-125-fdp release data provided complementary information. The former technique traced fiber dissolution, while the latter reflected network integrity. These results indicate that t-PA-induced fibrinolysis in PAI-1 enriched plasma is modulated by the presence of fibrin and by temperature. C1 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,MCGUIRE VET ADM HOSP,MED SERV,DEPT INTERNAL MED,RICHMOND,VA 23298. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,MCGUIRE VET ADM HOSP,MED SERV,DEPT PATHOL,RICHMOND,VA 23298. WALTER REED ARMY MED CTR,DIV MED,HEMATOL BRANCH,WASHINGTON,DC 20307. NR 22 TC 22 Z9 22 U1 0 U2 0 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD JAN 23 PY 1992 VL 67 IS 1 BP 106 EP 110 PG 5 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA HC095 UT WOS:A1992HC09500022 PM 1615464 ER PT J AU FARRIS, MM KLINGHOFFER, AA ROSSIN, JA TEVAULT, DE AF FARRIS, MM KLINGHOFFER, AA ROSSIN, JA TEVAULT, DE TI DEACTIVATION OF A PT/AL2O3 CATALYST DURING THE OXIDATION OF HEXAFLUOROPROPYLENE SO CATALYSIS TODAY LA English DT Article ID TREATED PT-GAMMA-AL2O3 CATALYSTS; PLATINUM; GAMMA-AL2O3; REDUCTION; XPS AB A 5% Pt/Al2O3 catalyst was exposed to hexafluoropropylene (HFP) at concentrations between 500 and 4,500 ppm in humid air at temperatures between 300 and 400-degrees-C. The catalyst was found to deactivate over all conditions investigated. Analysis of the catalyst following reaction exposure indicated that the catalyst support had been transformed to aluminum fluoride, and that virtually all of the support's surface area had been lost. The observed deactivation was attributed to degradation of the catalyst support, caused by a reaction between the alumina support and product hydrofluoric acid. Under some conditions, the rate of catalytic deactivation was found to be proportional to the number of moles of hexafluoropropylene reacted. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP FARRIS, MM (reprint author), GEOCENTERS INC,FT WASHINGTON,MD 20744, USA. NR 18 TC 11 Z9 12 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-5861 J9 CATAL TODAY JI Catal. Today PD JAN 22 PY 1992 VL 11 IS 4 BP 501 EP 516 DI 10.1016/0920-5861(92)80040-T PG 16 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical SC Chemistry; Engineering GA JV492 UT WOS:A1992JV49200005 ER PT J AU JOKUBAITIS, LK QUINN, MF AF JOKUBAITIS, LK QUINN, MF TI NEW ARMY METHOD IN STATING AND ASSESSING RAM REQUIREMENTS SO PROCEEDINGS ANNUAL RELIABILITY AND MAINTAINABILITY SYMPOSIUM LA English DT Article; Proceedings Paper CT 1992 ANNUAL SYMP ON RELIABILITY AND MAINTAINABILITY CY JAN 21-23, 1992 CL LAS VEGAS, NV SP IEEE, INST IND ENGINEERS, AMER SOC QUAL CONTROL, SYSTEM SAFETY SOC, SOC RELIAB ENGINEERS, SOC LOGIST ENGINEERS DE FAILURE DEFINITION; RAM SPECIFICATION; RAM INCENTIVES; SAMPLE DATA COLLECTION AB As history has shown, the establishment of reliability requirements for complex equipment operating under diversified and difficult environments is a challenging task. It is challenging to a point where a singular mission requirement expressed in generalized terms does not do the job. For this reason, the recently introduced U. S. Army methodology of specifying reliability both to assess its performance during a given mission and to determine the quality of the product with more all-inclusive logistics overtones covers all the aspects of reliability concerns. Additionally, the dictated approach to specify reliability in terms of reliability growth and bands minimizes the danger of beating a system to death without appropriate evaluation or a chance to establish its worthiness. The associated improvements in the techniques to assess reliability and to identify candidates for minimizing logistics burden and for approving cost-effectiveness will also enhance the quality of the product. The thrust of this effort has been, and is, to provide the most reliable equipment to the soldier in the field without shooting oneself in the foot during the process due to poor reliability specifications or assessment techniques. RP JOKUBAITIS, LK (reprint author), USA,TANK AUTOMOT COMMAND,DIV RAM ASSESSMENT & DATA,ATTN AMSTA QR,WARREN,MI 48397, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0149-144X J9 P ANNU REL MAINT SYM JI Proc. Annu. Reliab. Maintainab. Symp. PD JAN 21 PY 1992 IS SYM BP 19 EP 27 DI 10.1109/ARMS.1992.187795 PG 9 WC Engineering, Multidisciplinary; Engineering, Industrial SC Engineering GA HQ114 UT WOS:A1992HQ11400005 ER PT J AU HARTMAN, JA WHITT, JH AF HARTMAN, JA WHITT, JH TI R-AND-M-CONTRACTING STRATEGY SO PROCEEDINGS ANNUAL RELIABILITY AND MAINTAINABILITY SYMPOSIUM LA English DT Article; Proceedings Paper CT 1992 ANNUAL SYMP ON RELIABILITY AND MAINTAINABILITY CY JAN 21-23, 1992 CL LAS VEGAS, NV SP IEEE, INST IND ENGINEERS, AMER SOC QUAL CONTROL, SYSTEM SAFETY SOC, SOC RELIAB ENGINEERS, SOC LOGIST ENGINEERS DE R-AND-M CONTRACTING; TQM, R-AND-M REQUIREMENTS; R-AND-M TASKS; REVIEWS; DATA REQUIREMENTS AB This paper defines and describes a new approach to R & M contracting. The current approach to R & M contracting employed almost universally by the Government and industry is discussed, and the problems normally encountered are identified. The techniques and sources of data used in the preparation of R & M statements of work are identified and discussed. The application of Total Quality Management (TQM) principles and practices as a prerequisite to the new R&M contracting strategy is presented. A brief discussion of the procedures for defining and implementing the strategy is provided. The R & M contracting strategy presented in this paper will simplify the R & M program requirements definition process, ensure key R & M tasks are selected and appropriately tailored, and produce a cost-effective program. RP HARTMAN, JA (reprint author), USA,STRATEG DEF COMMAND,DIV PROD ASSURANCE,POB 1500,HUNTSVILLE,AL 35807, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0149-144X J9 P ANNU REL MAINT SYM JI Proc. Annu. Reliab. Maintainab. Symp. PD JAN 21 PY 1992 IS SYM BP 80 EP 84 DI 10.1109/ARMS.1992.187803 PG 5 WC Engineering, Multidisciplinary; Engineering, Industrial SC Engineering GA HQ114 UT WOS:A1992HQ11400013 ER PT J AU PINNICK, RG BISWAS, A PENDLETON, JD ARMSTRONG, RL AF PINNICK, RG BISWAS, A PENDLETON, JD ARMSTRONG, RL TI AEROSOL-INDUCED LASER BREAKDOWN THRESHOLDS - EFFECT OF RESONANT PARTICLES SO APPLIED OPTICS LA English DT Article ID STIMULATED RAMAN-SCATTERING; INDUCED AIR BREAKDOWN; TIME-RESOLVED SPECTROSCOPY; MICROMETER-SIZED DROPLETS; BRILLOUIN-SCATTERING; LIQUID DROPLETS; SINGLE; RADIATION; DEPENDENCE; EXPLOSION AB Laser intensity thresholds for the onset of stimulated Raman scattering and the breakdown in resonant micro-meter-sized droplets are reduced to below those for nonresonant droplets by a factor of approximately 3. This reduction is most likely caused by the enhancement of electromagnetic energy (photon) densities within the droplets over and above that in nonresonant droplets. The magnitude of the threshold reduction for breakdown is consistent with the assertion that (1) input (pump) wavelength resonances that initiate plasma have cavity Q's of approximately 10(4) and (2) finite regions of high-electromagnetic-energy density within the droplet, with dimensions of the order of the Debye length, are required to initiate plasma. RP PINNICK, RG (reprint author), ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 35 TC 11 Z9 11 U1 1 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 1992 VL 31 IS 3 BP 311 EP 318 PG 8 WC Optics SC Optics GA HB063 UT WOS:A1992HB06300003 PM 20717408 ER PT J AU HELLMAN, OC VANCAUWENBERGHE, O HERBOTS, N OLSON, J CULBERTSON, RJ CROFT, WJ AF HELLMAN, OC VANCAUWENBERGHE, O HERBOTS, N OLSON, J CULBERTSON, RJ CROFT, WJ TI STRUCTURE AND PROPERTIES OF SILICON-NITRIDE AND SIXGE1-X NITRIDE PREPARED BY DIRECT LOW-ENERGY ION-BEAM NITRIDATION SO MATERIALS SCIENCE AND ENGINEERING B-SOLID STATE MATERIALS FOR ADVANCED TECHNOLOGY LA English DT Article; Proceedings Paper CT SYMP AT THE 1991 SPRING MEETING OF THE EUROPEAN MATERIALS RESEARCH SOC : ION BEAM SYNTHESIS OF COMPOUND AND ELEMENTAL LAYERS CY MAY 28-31, 1991 CL STRASBOURG, FRANCE SP EUROPEAN MAT RES SOC ID ASSISTED DEPOSITION; ON-INSULATOR; IMPLANTATION; NITROGEN; FILMS AB Thin films of silicon nitride, germanium nitride and silicon germanium nitride were formed using direct low energy ion beam nitridation. In this process a monoenergetic nitrogen ion beam directly impinges on the material to be nitrided, in the present work Si(100), Ge/Si(100) and Si0.89Ge0.11/Si(100). The energies investigated ranged from 100 eV to 1 keV. Germanium and SiGe alloy were grown on Si(100) using molecular beam epitaxy. The kinetic energy of the ion beam introduces activated nitrogen species athermally into the substrate, and allows the formation of nitrides at low temperatures (20-420-degrees-C). Properties of the films such as stress, stoichiometry and microstructure are found to depend strongly on ion energy and substrate temperature. Film stress is highly compressive for samples deposited at room temperature, but decreases with temperature and becomes tensile at 420-degrees-C. Film thicknesses, as measured by cross-sectional transmission electron microscopy and Rutherford backscattering spectrometry, were found to be much greater than the projected range of the ions. The creation of an amorphous layer beneath the amorphous nitride film is observed, and is found to be a strong function of ion energy, temperature and nitrogen ion dose. C1 MIT,DEPT MAT SCI & ENGN,CAMBRIDGE,MA 02139. USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. NR 19 TC 5 Z9 5 U1 0 U2 3 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0921-5107 J9 MAT SCI ENG B-SOLID JI Mater. Sci. Eng. B-Solid State Mater. Adv. Technol. PD JAN 20 PY 1992 VL 12 IS 1-2 BP 53 EP 59 DI 10.1016/0921-5107(92)90258-B PG 7 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA HE158 UT WOS:A1992HE15800011 ER EF