FN Thomson Reuters Web of Science™ VR 1.0 PT J AU NELSON, KE CELENTANO, DD SUPRASERT, S WRIGHT, N EIUMTRAKUL, S TULVATANA, S MATANASARAWOOT, A AKARASEWI, P KUNTOLBUTRA, S ROMYEN, S SIRISOPANA, N THEETRANONT, C AF NELSON, KE CELENTANO, DD SUPRASERT, S WRIGHT, N EIUMTRAKUL, S TULVATANA, S MATANASARAWOOT, A AKARASEWI, P KUNTOLBUTRA, S ROMYEN, S SIRISOPANA, N THEETRANONT, C TI RISK-FACTORS FOR HIV-INFECTION AMONG YOUNG-ADULT MEN IN NORTHERN THAILAND SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID IMMUNODEFICIENCY-VIRUS-INFECTION; TRANSMISSION; WOMEN AB Objective.-To determine the sociodemographic and behavioral risk factors associated with human immunodeficiency virus (HIV) infection in two cohorts of young men selected for military service in northern Thailand. Design.-Military conscripts were studied cross-sectionally after conscription in May 1991 and November 1991. Risk factors were assessed by interview with trained nonmilitary interviewers. Setting.-Two military training bases in Chiang Mai, Thailand. Participants.-A total of 2417 young men aged 19 to 23 years (mean age, 21 years) conscripted by lottery into military service in the Royal Thai Army or Royal Thai Air Force from six provinces in northern Thailand. Main Outcome Measures.-Human immunodeficiency virus seroprevalence by enzyme-linked immunosorbent assay confirmed by Western blot and univariate and multivariate analyses of sociodemographic and behavioral risk factors associated with HIV seroprevalence. Results.-Overall, 289 (12.0%) of 2417 men were HIV-seropositive at baseline. The strongest associations with being HIV positive were heterosexual activities. History of sex with a female commercial sex worker (CSW) was frequent (96.5% of men who were HIV-positive and 79.0% of men who were HIV-negative) and strongly associated with HIV infection on univariate and multivariate analyses (adjusted odds ratio, 1.60 to 2.07, depending on the frequency of CSW contact). Also, sexually transmitted diseases were common and associated with HIV infection in both univariate and multivariate analyses (adjusted odds ratio, 3.36). Sex with other males and injection drug use were uncommon and not associated with HIV infection. Condom use was reported in 61.5% of men at last sex with a CSW but was not shown to be protective of prevalent HIV infection. Conclusion.-The epidemic of HIV infection has spread widely among young men in northern Thailand, despite reported frequent and recent use of condoms during sex with female CSWs. Control of HIV infection in this population will probably require more regular and effective use of condoms, prevention and treatment of sexually transmitted diseases, and reduction in the frequency of CSW contact. C1 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT HLTH POLICY & MANAGEMENT,BALTIMORE,MD 21205. CHIANG MAI UNIV,DEPT FAMILY MED,CHIANG MAI,THAILAND. CHIANG MAI UNIV,DEPT PATHOL,CHIANG MAI,THAILAND. MINIST PUBL HLTH,CHIANG MAI,THAILAND. ROYAL THAI ARMY,CHIANG MAI,THAILAND. ROYAL THAI AF,CHIANG MAI,THAILAND. ROBERT WOOD JOHNSON MED SCH,PISCATAWAY,NJ. ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RP NELSON, KE (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL,624 N BROADWAY,BALTIMORE,MD 21205, USA. NR 20 TC 125 Z9 127 U1 3 U2 4 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD AUG 25 PY 1993 VL 270 IS 8 BP 955 EP 960 DI 10.1001/jama.270.8.955 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA LT567 UT WOS:A1993LT56700026 PM 8345647 ER PT J AU ECKART, DW CASAS, LM AF ECKART, DW CASAS, LM TI SHALLOW ANGLE LAPPING OF III-V SEMICONDUCTOR THIN-LAYER STRUCTURES BY AN ION-BEAM CHEMICAL ETCHING TECHNIQUE SO APPLIED PHYSICS LETTERS LA English DT Article ID OXYGEN AB Layer thicknesses of < 2 nm have been resolved in GaAs-AlGaAs superlattice structures using a novel method involving the chemical etching of the shallow lapped area surrounding an ion beam sputter crater formed after Auger electron spectroscopy depth profiling. This method can be used to measure layer thickness variations across a wafer of a nominal 15 nm InGaAs layer in a pseudomorphic high electron mobility transistor. It can also be used to probe interlayer lattice mixing at selected areas on the wafer, for example, near an ohmic contact. RP ECKART, DW (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 23 PY 1993 VL 63 IS 8 BP 1041 EP 1043 DI 10.1063/1.109828 PG 3 WC Physics, Applied SC Physics GA LU095 UT WOS:A1993LU09500009 ER PT J AU ZAROMB, S AKINYEMI, A BIRENZVIGE, A TORRES, R AF ZAROMB, S AKINYEMI, A BIRENZVIGE, A TORRES, R TI PORTABLE HIGH-THROUGHPUT LIQUID-ABSORPTION AEROSOL SAMPLER SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES DEV & ENVIRONM CTR,ABERDEEN PROVING GROUND,MD 21010. NR 1 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 5 EP ENVR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP321 UT WOS:A1993LP32101373 ER PT J AU SHAW, RW AF SHAW, RW TI PHYSICAL-CHEMISTRY AND THE DOD ENVIRONMENTAL-QUALITY PLAN SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 11 EP PHYS PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP322 UT WOS:A1993LP32200763 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP TI REACTIONS OF TRIFLUOROMETHYLTHIOCOPPER WITH HALOMETHANES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD CHEM RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. GEOCENTERS INC,FT WASHINGTON,MD 20744. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 17 EP FLUO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP321 UT WOS:A1993LP32101520 ER PT J AU FAMINI, GR WILSON, LY AF FAMINI, GR WILSON, LY TI USING THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS - SOME APPLICATIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 21 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP321 UT WOS:A1993LP32101275 ER PT J AU ASHMAN, WP BLOOR, BC NELSON, TM MEEHAN, BS AF ASHMAN, WP BLOOR, BC NELSON, TM MEEHAN, BS TI STRUCTURE SEDATIVE ACTIVITY RELATIONSHIPS OF ALPHA2-ADRENERGIC COMPOUNDS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES,RES & TECHNOL DIRECTORATE,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. UNIV CALIF LOS ANGELES,DEPT ANESTHESIOL,LOS ANGELES,CA 90024. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 49 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP321 UT WOS:A1993LP32101303 ER PT J AU HUANG, XL FAMINI, GR AF HUANG, XL FAMINI, GR TI A COMPARATIVE MOLECULAR-ORBITAL STUDY OF THE REACTIVITY OF TRIMETHYL PHOSPHATE WITH ANIONIC NUCLEOPHILES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 61 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP321 UT WOS:A1993LP32101314 ER PT J AU DONOVAN, WH FAMINI, GR AF DONOVAN, WH FAMINI, GR TI A CONFORMATIONAL-ANALYSIS OF SULFUR MUSTARD SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD RTC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 63 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP321 UT WOS:A1993LP32101316 ER PT J AU STENHOUSE, PJ RATTO, JA DELL, PA AF STENHOUSE, PJ RATTO, JA DELL, PA TI SUB-T(G) RELAXATIONS IN STARCH POLY(ETHYLENE-CO-VINYL ALCOHOL) BLENDS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES & DEV LABS,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 77 EP CELL PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP321 UT WOS:A1993LP32100625 ER PT J AU BEAUDRY, WT WAGNER, GW AF BEAUDRY, WT WAGNER, GW TI METAL-ION CATALYZED-HYDROLYSIS OF ORGANOPHOSPHORUS ESTERS ON ION-EXCHANGE RESINS - NMR RELAXATION MEASUREMENTS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RDEC,RES & TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 78 EP INOR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP321 UT WOS:A1993LP32101897 ER PT J AU SLOAN, JM BODNAR, SC AF SLOAN, JM BODNAR, SC TI FLOODED CELL PERMEATION TESTING OF DMSO IN NATURAL-RUBBER SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,POLYMER RES BRANCH,WATERTOWN,MA 02172. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 98 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP322 UT WOS:A1993LP32201110 ER PT J AU SCHNEIDER, NS AF SCHNEIDER, NS TI THE EFFECT OF WATER ON THE GLASS-TRANSITION BEHAVIOR OF HYDROPHILIC POLYURETHANES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,NEWTON,MA 02159. USA,RES LAB,MAT DIRECTORATE,POLYMER RES BRANCH,WATERTOWN,MA 02172. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 122 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP322 UT WOS:A1993LP32201577 ER PT J AU LIEBMAN, SA PHILLIPS, C FITZGERALD, W LEVY, EJ PESCERODRIGUEZ, R MORRIS, J FIFER, RA AF LIEBMAN, SA PHILLIPS, C FITZGERALD, W LEVY, EJ PESCERODRIGUEZ, R MORRIS, J FIFER, RA TI INTEGRATED INTELLIGENT INSTRUMENTS FOR THE MATERIALS SCIENCES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 CCS INSTRUMENT SYST INC,AVONDALE,PA 19311. USA,RES LAB,ABERDEEN PR GR,MD 21005. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 129 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP322 UT WOS:A1993LP32201584 ER PT J AU MAYER, JM ELION, GR AF MAYER, JM ELION, GR TI PROCESSABILITY AND CHARACTERIZATION OF STARCH-BLEND FILMS PRODUCED USING DIFFERENT STARCH SOURCES AND AMYLOSE-AMYLOPECTIN RATIOS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR RES DEV & ENERGY,NATICK,MA 01760. INT COMMUN & ENERGY,CHATHAM,MA 02633. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 129 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP321 UT WOS:A1993LP32100129 ER PT J AU GULLIANI, D GALEZEWSKI, A WILUSZ, E AF GULLIANI, D GALEZEWSKI, A WILUSZ, E TI PROPERTIES OF ELASTOMERS BASED ON ISOBUTYLENE, ISOPRENE AND P-BROMOMETHYLSTYRENE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 182 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP322 UT WOS:A1993LP32201634 ER PT J AU BYRNE, CA DESPER, CR SCHNEIDER, NS CHU, B GAO, T AF BYRNE, CA DESPER, CR SCHNEIDER, NS CHU, B GAO, T TI POLYETHYLENE-BASED POLYURETHANE BLOCK-COPOLYMERS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,NEWTON,MA 02159. SUNY,DEPT CHEM,STONY BROOK,NY 11794. USA,RES LAB,AMSRL MA PP,WATERTOWN,MA 02172. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 264 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP322 UT WOS:A1993LP32201276 ER PT J AU DESPER, CR CHU, B LI, YJ BYRNE, CA AF DESPER, CR CHU, B LI, YJ BYRNE, CA TI MORPHOLOGY STUDIES OF CHDI URETHANE ELASTOMERS BY X-RAY-DIFFRACTION USING SYNCHROTRON-RADIATION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,POLYMER RES UNIT,WATERTOWN,MA 02172. SUNY,DEPT CHEM,STONY BROOK,NY 11794. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 269 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP322 UT WOS:A1993LP32201281 ER PT J AU SAMUELSON, LA LIM, JO KAMATH, M MARX, KA TRIPATHY, SK KAPLAN, DL AF SAMUELSON, LA LIM, JO KAMATH, M MARX, KA TRIPATHY, SK KAPLAN, DL TI THE COUPLING OF A THIOPHENE COPOLYMER TO A PHOTOACTIVE ANTENNAE PROTEIN USING BIOTIN STREPTAVIDIN COMPLEXATION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,CTR ADV MAT,DEPT CHEM,LOWELL,MA 01854. USA,NATWICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 327 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP322 UT WOS:A1993LP32201339 ER PT J AU AKKARA, JA BRUNO, F SAMUELSON, L AYYAGARI, M TRIPATHY, S MARX, K JOHN, VT KAPLAN, DL AF AKKARA, JA BRUNO, F SAMUELSON, L AYYAGARI, M TRIPATHY, S MARX, K JOHN, VT KAPLAN, DL TI SYNTHESIS OF 2-DIMENSIONAL ELECTROOPTIC POLYMER NETWORKS THROUGH BIOCATALYSIS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,DEPT CHEM,LOWELL,MA 01760. USA,NATWICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 22 PY 1993 VL 206 BP 365 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA LP322 UT WOS:A1993LP32201376 ER PT J AU RICE, BM CARTLAND, HE CHABALOWSKI, CF AF RICE, BM CARTLAND, HE CHABALOWSKI, CF TI AB-INITIO POTENTIAL-ENERGY SURFACE FOR THE H+OCS REACTION SO CHEMICAL PHYSICS LETTERS LA English DT Article ID PLESSET PERTURBATION CALCULATIONS; MODEL SN2 REACTIONS; CARBONYL SULFIDE; ATOMIC-HYDROGEN; BARRIER HEIGHTS; GEOMETRY; MP2 AB An ab initio MP4 study has been made of the potential energy surface of the H + OCS reaction. Minima and saddle points leading to formation of OH + CS or SH + CO were found. Stationary points were located using the 6-31G** basis set at the ROHF and UMP2 levels of theory, with energy refinements at the MP4(SDTQ) level. This theoretical study, in conjunction with the recent experimental results of Bohmer, Mikhaylichenko and Wittig, provides a mechanistic overview of the reactions of the H + OCS system. The results substantiate experimental hypotheses of the existence of stable, four-body reaction intermediates, as well as ''tight'' four-body transition states leading to products. Our calculations provide the first set of structural data that detail the reaction mechanisms for H + OCS going to SH + CO or OH + CS. RP RICE, BM (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 26 TC 15 Z9 15 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD AUG 20 PY 1993 VL 211 IS 4-5 BP 283 EP 292 DI 10.1016/0009-2614(93)87061-7 PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA LT225 UT WOS:A1993LT22500001 ER PT J AU ACTON, N KARLE, JM MILLER, RE AF ACTON, N KARLE, JM MILLER, RE TI SYNTHESIS AND ANTIMALARIAL ACTIVITY OF SOME 9-SUBSTITUTED ARTEMISININ DERIVATIVES SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID DIHYDROARTEMISININ DERIVATIVES; QINGHAOSU; ANALOGS; CONVERSION; MALARIA; INVITRO; DRUGS AB Several 9-substituted derivatives of the antimalarial drug artemisinin have been prepared by functionalizing the double bond of artemisitene and related compounds. Stereochemical assignments for these compounds were made using a combination of NMR experiments, an X-ray diffraction study of one compound, and chemical correlations of several other compounds with this one compound of unambiguous structure and with its epimer. The compounds synthesized show a wide variation in in vitro antimalarial activity. RP ACTON, N (reprint author), WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 19 TC 34 Z9 35 U1 3 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD AUG 20 PY 1993 VL 36 IS 17 BP 2552 EP 2557 DI 10.1021/jm00069a014 PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA LU544 UT WOS:A1993LU54400014 PM 8355254 ER PT J AU MORTON, DC KOH, J HOGH, CP KHORMAEI, R AF MORTON, DC KOH, J HOGH, CP KHORMAEI, R TI STUDY OF THE EFFECTS OF AGING ON THE RELAXATION LUMINANCE IN ATOMIC LAYER EPITAXY ZNS-MN ALTERNATING-CURRENT THIN-FILM ELECTROLUMINESCENT DEVICES SO APPLIED PHYSICS LETTERS LA English DT Article AB A study of the relaxation luminance peak and the electro-optical aging effects in atomic layer epitaxy (ALE) normally doped ZnS:Mn alternating-current thin-film electroluminescent (ACTFEL) devices is presented. The relaxation luminance occurs when the applied voltage goes to zero. The changes in the luminance versus time L(t), current versus time I(t), and characteristics of luminance versus voltage, as a function of aging are discussed in terms of a model which includes bulk traps, space charge, and shallow trap levels. This relaxation luminance peak observed in ALE devices provides a means of gaining insight into ACTFEL devices. C1 VITRON INC,EATONTOWN,NJ 07724. PLANAR SYST INC,BEAVERTON,OR 97006. RP MORTON, DC (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 15 TC 5 Z9 5 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 16 PY 1993 VL 63 IS 7 BP 863 EP 865 DI 10.1063/1.109882 PG 3 WC Physics, Applied SC Physics GA LT206 UT WOS:A1993LT20600003 ER PT J AU CHOI, KK TIDROW, MZ TAYSINGLARA, M CHANG, WH KUAN, CH FARLEY, CW CHANG, F AF CHOI, KK TIDROW, MZ TAYSINGLARA, M CHANG, WH KUAN, CH FARLEY, CW CHANG, F TI LOW DARK CURRENT INFRARED HOT-ELECTRON TRANSISTOR FOR 77-K OPERATION SO APPLIED PHYSICS LETTERS LA English DT Article ID ARRAY AB Recently, thermal imaging using quantum well infrared photodetector (QWIP) focal plane arrays has been demonstrated. However, the operating temperature needs to be kept around 60 K due to the large dark current occurring at higher temperatures. In order to achieve thermal imaging at 77 K, we have designed and demonstrated two infrared hot-electron transistor structures, whose dark current is two to three orders of magnitude lower than that of a QWIP. The resultant dark current falls within the limit of the charge handling capacity of a readout circuit, and the infrared detection is demonstrated to be background limited at 77 K. The noise equivalent temperature difference of the detectors is estimated to be 14 and 26 mK, respectively. C1 PRINCETON UNIV,DEPT ELECT ENGN,PRINCETON,NJ 08544. ROCKWELL INT CORP,CTR SCI,THOUSAND OAKS,CA 91360. RP CHOI, KK (reprint author), USA,RES LAB,EPSD,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 13 TC 26 Z9 26 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 16 PY 1993 VL 63 IS 7 BP 908 EP 910 DI 10.1063/1.109869 PG 3 WC Physics, Applied SC Physics GA LT206 UT WOS:A1993LT20600019 ER PT J AU RONG, FC HARVEY, JF POINDEXTER, EH GERARDI, GJ AF RONG, FC HARVEY, JF POINDEXTER, EH GERARDI, GJ TI NATURE OF P-B-LIKE DANGLING-ORBITAL CENTERS IN LUMINESCENT POROUS SILICON SO APPLIED PHYSICS LETTERS LA English DT Article ID 100 SILICON; INTERFACE; WAFERS; RESONANCE AB The P(b)-like dangling-orbit centers in luminescent porous silicon (LPSi) have been enhanced to very high concentration (10(15) cm-2) by gentle oxidation. High signal-to-noise ratio and very sharp lines enable the g-value maps, and Si-29 hyperfine and superhyperfine structures to be clearly resolved by ordinary EPR. Only one P(b)-like center is observed, and it is proven to be of the P(b0) variety (.Si=Si3). The relative EPR signal strengths from different g limbs indicate that the LPSi crystallite morphology is not dominated by needles or platelets. C1 WILLIAM PATERSON COLL NEW JERSEY,WAYNE,NJ 07470. RP RONG, FC (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 20 TC 35 Z9 35 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 16 PY 1993 VL 63 IS 7 BP 920 EP 922 DI 10.1063/1.109845 PG 3 WC Physics, Applied SC Physics GA LT206 UT WOS:A1993LT20600023 ER PT J AU NEWMAN, RA PETERSON, B DAVEY, FR BRABYN, C COLLINS, H BRUNETTO, VL DUGGAN, DB WEISS, RB ROYSTON, I MILLARD, FE MILLER, AA BLOOMFIELD, CD AF NEWMAN, RA PETERSON, B DAVEY, FR BRABYN, C COLLINS, H BRUNETTO, VL DUGGAN, DB WEISS, RB ROYSTON, I MILLARD, FE MILLER, AA BLOOMFIELD, CD TI PHENOTYPIC MARKERS AND BCL-1 GENE REARRANGEMENTS IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA - A CANCER AND LEUKEMIA GROUP-B STUDY SO BLOOD LA English DT Article ID T(11-14) CHROMOSOME-TRANSLOCATION; NON-HODGKINS-LYMPHOMAS; T-CELLS; EXPRESSION; CLASSIFICATION; CD11C; DIFFERENTIATION; IDENTIFICATION; DETERMINANTS; BREAKPOINT C1 UNIV CALIF SAN DIEGO,CTR CANC,DEPT MED,LA JOLLA,CA 92093. DUKE UNIV,MED CTR,CALGB STAT OFF,DURHAM,NC 27710. SUNY HLTH SCI CTR,DEPT PATHOL,SYRACUSE,NY. ROSWELL PK CANC INST,DEPT MED,BUFFALO,NY. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. USN HOSP,DEPT MED,SAN DIEGO,CA 92134. UNIV TENNESSEE CTR HLTH SCI,DEPT MED,MEMPHIS,TN 38163. FU NCI NIH HHS [CA21060-15, CA26806-12, CA37027-09] NR 31 TC 74 Z9 74 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD AUG 15 PY 1993 VL 82 IS 4 BP 1239 EP 1246 PG 8 WC Hematology SC Hematology GA LT742 UT WOS:A1993LT74200025 PM 8102560 ER PT J AU PHILLIPS, RW KIKENDALL, JW LUK, GD WILLIS, SM MURPHY, JR MAYDONOVITCH, C BOWEN, PE STACEWICZSAPUNTZAKIS, M WONG, RKH AF PHILLIPS, RW KIKENDALL, JW LUK, GD WILLIS, SM MURPHY, JR MAYDONOVITCH, C BOWEN, PE STACEWICZSAPUNTZAKIS, M WONG, RKH TI BETA-CAROTENE INHIBITS RECTAL MUCOSAL ORNITHINE DECARBOXYLASE ACTIVITY IN COLON-CANCER PATIENTS SO CANCER RESEARCH LA English DT Article ID NEOPLASTIC GROWTH; RAT; INDUCTION; ANTIOXIDANT; BIOMARKERS AB Colonic adenocarcinoma affects approximately 6% of adults in many Western countries. Beta-carotene (BC), a safe, inexpensive, and widely available compound, has been proposed as a cancer chemopreventive agent. To evaluate whether BC shows promise as an inhibitor of colonic carcinogenesis, we studied 20 male subjects who had previously undergone resection of colonic adenocarcinoma. Each subject received beta-carotene, 30 mg orally, daily for 6 months. Rectal mucosa was sampled at multiple intervals prior to, during, and following BC administration. Mucosal ornithine decarboxylase (ODC) activity and serum and mucosal BC concentrations were determined at each interval. ODC activity was inhibited by 44% (P < 0.05) and 57% (P < 0.01) after 2 and 9 weeks, respectively, of BC administration and remained low compared with baseline even 6 months following discontinuation of BC. Serum and mucosal BC concentrations increased as expected during BC administration and remained elevated for 6 months following BC discontinuation. The demonstrated inhibition of rectal mucosal ODC activity in these patients with resected colon cancer suggests that BC may prove useful as a cancer chemopreventive agent. C1 WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. UNIV ILLINOIS,DEPT NUTR & MED DIETET,CHICAGO,IL 60612. UNIV TEXAS,SW MED CTR,DALLAS,TX 75216. DEPT VET AFFAIRS MED CTR,DALLAS,TX 75216. FU NCI NIH HHS [UO1 CA 50399] NR 22 TC 44 Z9 44 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD AUG 15 PY 1993 VL 53 IS 16 BP 3723 EP 3725 PG 3 WC Oncology SC Oncology GA LR765 UT WOS:A1993LR76500015 PM 8339282 ER PT J AU SELTZER, MD GRUBER, JB HILLS, ME QUARLES, GJ MORRISON, CA AF SELTZER, MD GRUBER, JB HILLS, ME QUARLES, GJ MORRISON, CA TI MULTISITE OPTICAL-SPECTRA AND ENERGY-LEVELS OF TRIVALENT THULIUM IONS IN YTTRIUM SCANDIUM GALLIUM GARNET SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID GROWTH AB Intrinsic structural disorder in scandium-substituted garnets, attributed to mixed occupancy o certain sites in the crystal lattice by different cations, has direct consequences for the optical spectra of rare-earth activator ions dispersed over multiple sites. In trivalent thulium-doped yttrium scandium gallium garnet (Tm3+:YSGG), site-selective laser excitation spectra reveal the presence of Tm3+ ions in regular D2 sites, disturbed regular sites, and in octahedral C3i sites. Absorption spectra obtained at 4 K between 0.26 and 1.85 mum are broader than those observed in more-ordered crystal hosts and include structure attributed to Tm3+ ions in sites of other than D2 symmetry. A crystal-field splitting calculation was carried out in which a parametrized Hamiltonian (including Coulombic, spin-orbit, and crystal-field terms for Tm3+ ions in D2 symmetry) was diagonalized for all manifolds of the Tm3+ (4f12) configuration. The rms deviation between 52 experimental and calculated Stark levels of Tm3+ in regular D2 sites was 5 cm-1. C1 SAN JOSE STATE UNIV,DEPT PHYS,SAN JOSE,CA 95192. USN,RES LAB,ELECTROOPT TECHNOL BRANCH,WASHINGTON,DC 20375. USA,ADELPHI LAB COMMAND,HARRY DIAMOND LABS,ADELPHI,MD 20783. RP SELTZER, MD (reprint author), USN,CTR AIR WARFARE,DIV WEAPONS,DIV CHEM,CHINA LAKE,CA 93555, USA. NR 17 TC 16 Z9 16 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 15 PY 1993 VL 74 IS 4 BP 2821 EP 2829 DI 10.1063/1.354633 PG 9 WC Physics, Applied SC Physics GA LT183 UT WOS:A1993LT18300099 ER PT J AU LU, XJ RHODES, D PERLMAN, BS AF LU, XJ RHODES, D PERLMAN, BS TI HIGH-FREQUENCY CAPACITIVE EFFECTS IN RESONANT-TUNNELING DIODES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID DOUBLE-BARRIER DIODES; FINITE-SUPERLATTICE; OSCILLATIONS; MICROWAVE; MODEL; GHZ AB The time-varying charge buildup in the quantum well region of a resonant tunneling diode (RTD) and related capacitive effects are calculated using the scattering matrix method developed. The small signal analysis of admittance shows a prominent influence from the capacitive effect, due to the dynamic shifting of the resonant energy levels. The model developed is helpful for understanding the RTD's high-frequency behavior and device applications. RP LU, XJ (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 15 PY 1993 VL 74 IS 4 BP 2908 EP 2913 DI 10.1063/1.355292 PG 6 WC Physics, Applied SC Physics GA LT183 UT WOS:A1993LT18300112 ER PT J AU REEVES, MS CHATFIELD, DC TRUHLAR, DG AF REEVES, MS CHATFIELD, DC TRUHLAR, DG TI PRECONDITIONED COMPLEX GENERALIZED MINIMAL RESIDUAL ALGORITHM FOR DENSE ALGEBRAIC VARIATIONAL EQUATIONS IN QUANTUM REACTIVE SCATTERING SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID LINEAR-SYSTEMS; CHEMICAL-REACTIONS; ITERATIVE SOLUTION; COLLISIONS; HD; PROBABILITIES; PRINCIPLE; MATRIX; WAVE; D2 AB Variational basis-set formulations of the quantum mechanical reactive scattering problem lead to large, dense sets of equations. In previous work, we showed that the generalized minimal residual (GMRes) algorithm is sometimes competitive in terms of computer time with direct methods for these dense matrices, even when complex-valued boundary conditions are used, leading to non-Hermitian matrices. This paper presents a preconditioning scheme to accelerate convergence and improve performance. We block the potential energy coupling into a series of distortion blocks, and we employ the outgoing wave variational principle with nonorthogonal basis functions, including both dynamically adapted Green's functions for the distortion blocks and also square integrable functions. The coefficient matrix of the resulting linear system couples the blocks. We have found that preconditioners formed from diagonal blocks of the coefficient matrix corresponding to the distortion blocks and vibrational blocks are effective at accelerating the iterative method in every test case, by factors of 2.9-20, with an average speedup of a factor of 6.5. The storage requirements and computational efficiency of the new scheme compare favorably to those for preconditioners based on banded matrices of variable bandwidth. The new preconditioners yield converged transition probabilities in less computer time than a direct solver even in cases which do not converge in a reasonable amount of time without preconditioning, and the average speedup compared to the direct solution is a factor of 7.6. C1 UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. RP REEVES, MS (reprint author), UNIV MINNESOTA, DEPT CHEM, INST SUPERCOMP, MINNEAPOLIS, MN 55455 USA. RI Truhlar, Donald/G-7076-2015 OI Truhlar, Donald/0000-0002-7742-7294 NR 42 TC 10 Z9 10 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD AUG 15 PY 1993 VL 99 IS 4 BP 2739 EP 2751 DI 10.1063/1.465182 PG 13 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA LR056 UT WOS:A1993LR05600046 ER PT J AU FRANCIS, ML MELTZER, MS AF FRANCIS, ML MELTZER, MS TI INDUCTION OF IFN-ALPHA BY HIV-1 IN MONOCYTE-ENRICHED PBMC REQUIRES GP120-CD4 INTERACTION BUT NOT VIRUS-REPLICATION SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; HERPES-SIMPLEX VIRUS; BLOOD MONONUCLEAR-CELLS; HUMAN PERIPHERAL-BLOOD; ENVELOPE V3 LOOP; INTERFERON-ALPHA; INFECTED MONOCYTES; SENDAI VIRUS; TYPE-1 INFECTION; MESSENGER-RNA AB IFN-alpha is in plasma of HIV-1 infected patients during early and late-stage disease and may play a role in control of virus replication. The stimulus for IFN-alpha production, the cells that produce this cytokine, and the effectiveness of this IFN-alpha response for control of virus infection are not yet defined. Culture fluids from freshly isolated PBMC of HIV-1 seronegative donors contained high levels of IFN-alpha after exposure to 100 to 1000 infectious HIV-1 particles per culture. Levels of IFN-alpha induced by HIV-1 were directly dependent on the number of monocytes in cell preparations: No IFN-alpha was detected from T cell-enriched PBMC. In monocyte cultures, induction of IFN-alpha by HIV-1 was relatively specific: Levels of IL-1beta, IL-6, IFN-gamma, and TNF-alpha remained at baseline. Capacity of HIV-1 virions to induce IFN-alpha was not dependent on virus replication. IFN-alpha was induced by (a) heat-inactivated HIV-1, (b) virions from 8E5 cells, a cell line that releases noninfectious HIV-1, (c) HIV-1-infected cells fixed in paraformaldehyde, and (d) T cell-tropic HIV-1 that binds to but does not infect monocytes. Capacity of HIV-1 virions and HIV-1 infected cells to induce IFN-alpha was completely inhibited by soluble rCD4 or mAb against CD4 or gp120. Antibodies against CD4, however, did not induce monocytes to produce IFN-alpha. HIV-1-induced IFN-alpha production was inhibited by antibodies against both V3 loop determinants and the CD4 binding site of gp120. Further, sera and purified immunoglobulin from HIV-1 infected patients also inhibited HIV-1-induced IFN-alpha production. These observations suggest that potentially protective antiviral responses associated with IFN-alpha production in HIV-1 infected patients are inhibited by the development of antibodies against gp120. RP FRANCIS, ML (reprint author), WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,HIV IMMUNOPATHOGENESIS PROGRAM,9620 MED CTR DR,ROCKVILLE,MD 20850, USA. NR 53 TC 58 Z9 58 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD AUG 15 PY 1993 VL 151 IS 4 BP 2208 EP 2216 PG 9 WC Immunology SC Immunology GA LR904 UT WOS:A1993LR90400047 PM 8345204 ER PT J AU ZHOU, WM DUTTA, M SMITH, DD PAMULAPATI, J SHEN, H NEWMAN, P SACKS, R AF ZHOU, WM DUTTA, M SMITH, DD PAMULAPATI, J SHEN, H NEWMAN, P SACKS, R TI MAGNETOOPTICAL STUDIES OF STRAIN EFFECTS ON THE EXCITONS IN INXGA1-XAS/ALYGA1-YAS STRAINED QUANTUM-WELLS SO PHYSICAL REVIEW B LA English DT Article ID BINDING-ENERGY; LAYER SUPERLATTICES; HETEROSTRUCTURES; INXGA1-XAS/GAAS; MAGNETOEXCITONS AB Low-temperature (4.2 K) magnetoreflectance measurements have been performed on a series of InxGa1-xAs/AlyGa1-yAs strained-layer quantum wells (QW's) with the InAs mole fraction x varying from 0 to 0.2, for three different well widths, and for the magnetic-field range of 0-9 T. The diamagnetic shift data of 1s, 2s, 3s,... excitons are fit to a theoretical model to determine the exciton binding energies and the in-plane reduced effective masses, which are presented as a function of x, for excitons in 80, 120, and 340 angstrom InxGa1-xAs/AlyGa1-yAs QW's. In the case of high-barrier QW's, the binding energies and effective masses appear to decrease linearly with increasing x over the range studied. The rate of change of the effective mass mu as x increases from 0 to 0.2 is experimentally determined, using two different methods, to be dmu/dx = -0.057m0 and dmu/dx = -0.041m0, which exhibits a substantial strain dependence when compared with the value dmu/dx = -0.07m0, from unstrained bulk InxGa1-xAs. A theoretical approach taking into account the effect of composition change in the QW and 'strain on both the conduction and valence bands is made and gives dmu/dx = -0.051m0, which is in good agreement with our experimental result. C1 UNITED TECHNOL RES CTR,E HARTFORD,CT 06108. RP ZHOU, WM (reprint author), USA,RES LAB,EPSD,FT MONMOUTH,NJ 07703, USA. NR 20 TC 13 Z9 13 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD AUG 15 PY 1993 VL 48 IS 8 BP 5256 EP 5260 DI 10.1103/PhysRevB.48.5256 PG 5 WC Physics, Condensed Matter SC Physics GA LV385 UT WOS:A1993LV38500032 ER PT J AU ALVING, CR DETRICK, B RICHARDS, RL LEWIS, MG SHAFFERMAN, A EDDY, GA AF ALVING, CR DETRICK, B RICHARDS, RL LEWIS, MG SHAFFERMAN, A EDDY, GA TI NOVEL ADJUVANT STRATEGIES FOR EXPERIMENTAL MALARIA AND AIDS VACCINES SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID CELL C1 GEORGE WASHINGTON UNIV, MED CTR, CLIN IMMUNOL LAB, WASHINGTON, DC 20037 USA. HENRY M JACKSON FDN ADVANCEMENT MIL MED, ROCKVILLE, MD 20850 USA. ISRAEL INST BIOL RES, NESS ZIONA, ISRAEL. RP ALVING, CR (reprint author), WALTER REED ARMY MED CTR, DEPT MEMBRANE BIOCHEM, WASHINGTON, DC 20307 USA. NR 24 TC 1 Z9 1 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 USA SN 0077-8923 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PD AUG 12 PY 1993 VL 690 BP 265 EP 275 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA LX021 UT WOS:A1993LX02100028 ER PT J AU CHENG, F ANDRES, P YU, FTS GREGORY, D AF CHENG, F ANDRES, P YU, FTS GREGORY, D TI INTENSITY COMPENSATION FIBER FOR JOINT TRANSFORM CORRELATION PEAK ENHANCEMENT SO APPLIED OPTICS LA English DT Article ID FILTERS; BINARIZATION AB A spatial filtering technique is proposed to sharpen the correlation peak for a joint transform correlator (JTC) by using the inverse reference power spectrum. Ways of handling the pole problems are discussed under various noise conditions. The minimum mean-square-error method is used to locate the optimum bias value and to estimate threshold level as applied to eradicate the poles. Applications to multitarget recognition and spectral fringe binarization are also studied. Computer-simulated results show that the compensated JTC performs better than the conventional JTC. C1 USA, MISSILE COMMAND, REDSTONE ARSENAL, AL 35898 USA. RP CHENG, F (reprint author), PENN STATE UNIV, DEPT ELECT & COMP ENGN, UNIV PK, PA 16802 USA. NR 11 TC 32 Z9 33 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD AUG 10 PY 1993 VL 32 IS 23 BP 4357 EP 4364 PG 8 WC Optics SC Optics GA LQ797 UT WOS:A1993LQ79700008 PM 20830093 ER PT J AU EVERITT, HO DELUCIA, FC AF EVERITT, HO DELUCIA, FC TI THE TEMPERATURE-DEPENDENCE OF FAST VIBRATIONAL-ENERGY TRANSFER PROCESSES IN METHYL-FLUORIDE SO MOLECULAR PHYSICS LA English DT Article ID INFRARED DOUBLE-RESONANCE; MILLIMETER-WAVE; LASER; SPECTROSCOPY; (CH3F)-C-13; DYNAMICS; CH3F AB The temperature dependencies of two fast vibrational energy transfer processes in methyl fluoride (CH3F) have been measured between 120 K and 400 K by means of time-resolved millimetre/submillimetre-infrared double resonance spectroscopy. The first of these processes, a resonant vibrational swapping process between the ground vibrational state and the nu3 = 1 (nu3) vibrational state, effectively transfers population between states of A and E symmetry. A rapid increase in cross section with decreasing temperature was observed for this process, a result in excellent quantitative agreement with semiclassical theory of near resonant vibrational collisions. The second process, which transfers population between the nu3 and nu6 = 1 (nu6) vibrational states, was found experimentally to have a much weaker temperature dependence. From this result and from additional experimental observations of symmetry type-sensitive energy transfer into nu6, the energy transfer between nu3 and nu6 was demonstrated to result from a 'direct' vibrational energy transfer rather than from an 'indirect' vibrational swap process. C1 OHIO STATE UNIV,DEPT PHYS,COLUMBUS,OH 43210. RP EVERITT, HO (reprint author), USA,RES OFF,POB 12211,RES TRIANGLE PK,NC, USA. RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 NR 25 TC 2 Z9 2 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0026-8976 J9 MOL PHYS JI Mol. Phys. PD AUG 10 PY 1993 VL 79 IS 5 BP 1087 EP 1101 DI 10.1080/00268979300101851 PG 15 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA LR638 UT WOS:A1993LR63800013 ER PT J AU CASEY, HC CHEN, CH ZAVADA, JM NOVAK, SW AF CASEY, HC CHEN, CH ZAVADA, JM NOVAK, SW TI ANALYSIS OF HYDROGEN DIFFUSION FROM PROTON-EXCHANGED LAYERS IN LINBO3 SO APPLIED PHYSICS LETTERS LA English DT Article ID WAVE-GUIDES; WAVEGUIDES AB Hydrogen profiles for proton-exchanged layers in Z-cut LiNbO3 were obtained by secondary ion mass spectrometry measurements after annealing at 400-degrees-C for times from 6 to 180 min. To fit the measured hydrogen profiles, it was necessary to use two separate Gaussian diffusion profiles which could be designated as a more slowly diffusing substitutional hydrogen on lithium sites and a more rapidly diffusing interstitial hydrogen. At 400-degrees-C, analysis leads to a substitutional hydrogen diffusion coefficient D(s) almost-equal-to 4.6 X 10(-12) cm2/s and an interstitial hydrogen diffusion coefficient D(i) almost-equal-to 1.5 x 10(-11) cm2/S. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. EVANS EAST INC,PLAINSBORO,NJ 08536. RP CASEY, HC (reprint author), DUKE UNIV,DEPT ELECT ENGN,BOX 90291,DURHAM,NC 27708, USA. NR 10 TC 12 Z9 12 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 9 PY 1993 VL 63 IS 6 BP 718 EP 720 DI 10.1063/1.109938 PG 3 WC Physics, Applied SC Physics GA LR258 UT WOS:A1993LR25800004 ER PT J AU ZHANG, K WU, DW FU, JM MILLER, DL FUKUDA, M YUN, YH SCHAUER, S AF ZHANG, K WU, DW FU, JM MILLER, DL FUKUDA, M YUN, YH SCHAUER, S TI LOW-TEMPERATURE MIGRATION-ENHANCED EPITAXY OF BASE MATERIAL FOR ALGAAS/GAAS HETEROJUNCTION BIPOLAR-TRANSISTORS SO APPLIED PHYSICS LETTERS LA English DT Article ID DOPED GAAS; DIFFUSION AB Migration enhanced epitaxy (MEE) was used in this work to grow p+-GaAs at the substrate temperature of 300-degrees-C for the base of AlGaAs/GaAs heterojunction bipolar transistors. The results indicated that the low-temperature MEE-grown p+-GaAs epitaxial layers (p = 1 X 10(19) -1 X 10(20) CM-3) exhibited a crystalline quality comparable to those grown by standard MBE at a substrate temperature of 570-degrees-C. AlGaAs/GaAs HBTs with low-temperature MEE-grown bases doped at p almost-equal-to 2 X 10(19) cm-3 were fabricated by using a self-alignment technique. For the devices with the conventional MBE-grown base, secondary ion mass spectroscopy depth profiles showed a significant Be diffusion into the AlGaAs emitter and as a consequence, the devices showed no current gain. For the devices with the low-temperature MBE-grown base, there was a negligible Be penetration into the emitter and the devices exhibited a common-emitter dc current gain of 13. C1 PENN STATE UNIV,DEPT ELECT & COMP ENGN,UNIV PK,PA 16802. PENN STATE UNIV,DEPT MAT SCI & ENGN,UNIV PK,PA 16802. M-A-COM INC,CTR CORP R&D,LOWELL,MA 01851. USA,ETDL,FT MONMOUTH,NJ 07703. PENN STATE UNIV,DEPT PHYS,UNIV PK,PA 16802. RP ZHANG, K (reprint author), PENN STATE UNIV,ELECTR MAT & PROC RES LAB,UNIV PK,PA 16802, USA. NR 13 TC 3 Z9 3 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 9 PY 1993 VL 63 IS 6 BP 809 EP 811 DI 10.1063/1.109915 PG 3 WC Physics, Applied SC Physics GA LR258 UT WOS:A1993LR25800035 ER PT J AU LEE, LE FONSECA, V BRETT, KM SANCHEZ, J MULLEN, RC QUENEMOEN, LE GROSECLOSE, SL HOPKINS, RS AF LEE, LE FONSECA, V BRETT, KM SANCHEZ, J MULLEN, RC QUENEMOEN, LE GROSECLOSE, SL HOPKINS, RS TI ACTIVE MORBIDITY SURVEILLANCE AFTER HURRICANE-ANDREW - FLORIDA, 1992 SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID FLOOD AB Objective.-To describe the health status of and to detect disease outbreaks in the population affected by Hurricane Andrew in south Dade County, Florida. Design.-The Florida Department of Health and Rehabilitative Services and the US Army conducted active surveillance for gastrointestinal illness, respiratory illness, injury, and other index conditions by monitoring civilian and service member visits to care sites (civilian and military free care sites and hospital emergency departments) from August 30 (1 week after the hurricane's landfall) through September 30,1992. Setting.-South Dade County, Florida. Main Outcome Measures.-Proportional morbidity: the number of daily visits for each index condition divided by the total number of visits, expressed as a percentage. Morbidity rate: the total number of daily visits by service members divided by the total number of service members, expressed as a percentage. Results.-Six index conditions accounted for 41.3% of visits to civilian free care sites: diarrhea (4.7%), cough (4.7%), other infection (9.6%), rash (5.4%), animal bite (1.2%), and injury (15.7%). At military free care sites, five index conditions accounted for 75.7% of civilian visits: injury (23.7%), dermatologic illness (12.4%), respiratory illness (9.9%), gastrointestinal illness (5.3%), and other medical conditions (24.4%). Two index conditions accounted for 54.1 % of service member visits: injury (36.2%) and dermatologic illness (17.9%). During the 5 weeks after the hurricane, proportional morbidity from injury decreased; proportional morbidity from respiratory illness increased; and proportional morbidity from diarrhea was stable. No infectious disease outbreaks occurred. Conclusions.-Injuries were an important source of morbidity throughout the surveillance period, especially among service members. Enteric and respiratory agents did not cause disease outbreaks, despite alarming rumors to the contrary. C1 CTR DIS CONTROL & PREVENT,NATL CTR HLTH STAT,DIV ANAL,OFF ANAL & EPIDEMIOL,ATLANTA,GA 30333. FLORIDA DEPT HLTH & REHABIL SERV,OFF DIS CONTROL & AIDS PREVENT,EPIDEMIOL PROGRAM,TALLAHASSEE,FL. CTR DIS CONTROL & PREVENT,NATL CTR ENVIRONM HLTH,DIV ENVIRONM HAZARDS & HLTH EFFECTS,ATLANTA,GA 30333. WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307. RP LEE, LE (reprint author), CTR DIS CONTROL & PREVENT,NATL CTR HLTH STAT,DIV FIELD EPIDEMIOL,EPIDEMIOL PROGRAM OFF,ATLANTA,GA 30333, USA. NR 9 TC 35 Z9 35 U1 2 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD AUG 4 PY 1993 VL 270 IS 5 BP 591 EP 594 DI 10.1001/jama.270.5.591 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA LP436 UT WOS:A1993LP43600023 PM 8331757 ER PT J AU MOSES, FM AF MOSES, FM TI GASTROINTESTINAL-BLEEDING AND THE ATHLETE SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Review ID LONG-DISTANCE RUNNERS; MARATHON RUNNERS; ISCHEMIC COLITIS; IRON-DEFICIENCY; HEMORRHAGIC-SHOCK; GASTRIC-LESIONS; EXOGENOUS ACID; BLOOD-LOSS; EXERCISE; ANEMIA RP MOSES, FM (reprint author), WALTER REED ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. NR 44 TC 36 Z9 36 U1 2 U2 3 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD AUG PY 1993 VL 88 IS 8 BP 1157 EP 1159 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA LQ793 UT WOS:A1993LQ79300003 PM 8338081 ER PT J AU HARRINGTON, GR HNATIUK, OW AF HARRINGTON, GR HNATIUK, OW TI NONINVASIVE MONITORING SO AMERICAN JOURNAL OF MEDICINE LA English DT Review ID PULMONARY-ARTERY CATHETERS; BLOOD-PRESSURE; CARDIAC-OUTPUT; THERMODILUTION; BIOIMPEDANCE; SPECTROSCOPY; ACCURACIES; DEVICES; FINGER; SHOCK AB Noninvasive monitors are finding increased use in the intensive care unit both as labor-saving tools and as a means to reduce complications associated with invasive techniques. The current technology allows for the replacement of a number of invasive devices with a noninvasive counterpart capable of providing similar information. The potential reduction in morbidity and mortality realized with a greater reliance on noninvasive monitors should result in widespread application of these modalities. C1 WALTER REED ARMY MED CTR,CRIT CARE MED SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 43 TC 2 Z9 2 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD AUG PY 1993 VL 95 IS 2 BP 221 EP 228 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA LT427 UT WOS:A1993LT42700014 PM 8356987 ER PT J AU DILLINGHAM, TR SPELLMAN, NT BRAVERMAN, SE ZEIGLER, DN BELANDRES, PV BRYANT, PR SALCEDO, VL SCHNEIDER, RL AF DILLINGHAM, TR SPELLMAN, NT BRAVERMAN, SE ZEIGLER, DN BELANDRES, PV BRYANT, PR SALCEDO, VL SCHNEIDER, RL TI ANALYSIS OF CASUALTIES REFERRED TO ARMY PHYSICAL MEDICINE SERVICES DURING THE PERSIAN-GULF CONFLICT SO AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION LA English DT Article DE REHABILITATION; WAR; AMPUTATION; NERVE INJURIES ID LEBANON WAR; CARE AB This study describes the casualties referred during the Persian Gulf War and underscores the valuable role of Army physical medicine and rehabilitation (PMR) services in evaluation and early rehabilitation of wartime casualties. Data regarding demographics, injury types, medical complications, complications of immobility and functional limitations were collected by military physiatrists at five Army Medical Centers with PMR services. Active duty soldiers injured in the Persian Gulf War who were referred totalled 222. Musculoskeletal injuries occurred in 57%, peripheral nerve injuries in 44%, penetrating wounds in 32%, fractures in 28%, brain injuries in 8%, amputations in 7%, burns in 6% and spinal cord injuries in 3%. The primary referral service was orthopedics (64%). Electrodiagnostic evaluations were performed for 41% of all referrals. Lower limb and upper limb contractures occurred in 10% and 9% of patients, respectively. Ambulatory impairments were seen in 48%. Nerve injuries were associated with penetrating wounds in 68%, with amputations in 67% and with fractures in 58%. C1 FITZSIMONS ARMY MED CTR,PHYS MED SERV,AURORA,CO 80045. CHILDRENS HOSP,NATL MED CTR,PHYS MED SERV,WASHINGTON,DC 20010. RP DILLINGHAM, TR (reprint author), WALTER REED ARMY MED CTR,PHYS MED & REHABIL SERV,WASHINGTON,DC 20307, USA. NR 9 TC 11 Z9 13 U1 0 U2 3 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0894-9115 J9 AM J PHYS MED REHAB JI Am. J. Phys. Med. Rehabil. PD AUG PY 1993 VL 72 IS 4 BP 214 EP 218 DI 10.1097/00002060-199308000-00008 PG 5 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA LU176 UT WOS:A1993LU17600008 PM 8363817 ER PT J AU JENSEN, PS SHERVETTE, RE XENAKIS, SN RICHTERS, J AF JENSEN, PS SHERVETTE, RE XENAKIS, SN RICHTERS, J TI ANXIETY AND DEPRESSIVE-DISORDERS IN ATTENTION-DEFICIT DISORDER WITH HYPERACTIVITY - NEW FINDINGS SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Article ID CHILDREN; POPULATION; INTERVIEWS; INVENTORY; CONDUCT AB Objective: The authors examined the discriminant validity of the diagnosis of attention deficit disorder with hyperactivity. Method. They used standardized rating scales of life stresses and child and family functioning to assess psychosocial and family risk factors in 47 children who had the diagnosis of attention deficit disorder with hyperactivity, a matched group of 47 children in the community, and a matched group of 47 children seen in a psychiatric clinic. Results: Children who had the diagnosis of attention deficit disorder and children in the psychiatric clinic reported significantly more depression and anxiety than did the children in the community, furthermore, children diagnosed as having attention deficit disorder with hyperactivity bad more externalizing symptoms than did children in the psychiatric clinic. Children diagnosed as having attention deficit disorder with hyperactivity plus a comorbid anxiety or depressive disorder had higher levels of coexisting life stresses and parental symptoms than did children who had the single diagnosis of attention deficit disorder with hyperactivity. Conclusions: These results underscore the need for future studies to carefully assess children diagnosed as having attention deficit disorder with hyperactivity for concurrent psychiatric disorders as well as family and psychosocial stressors that may contribute to childhood symptoms. Such information is essential because different subtypes of attention deficit disorder with comorbid disorders may arise from different etiologic pathways, may require varying treatment options, and may foreshadow different eventual outcomes. C1 EISENHOWER ARMY MED CTR,DEPT PSYCHIAT & NEUROL,FT GORDON,GA. OI Richters, John/0000-0002-6780-1828; Jensen, Peter/0000-0003-2387-0650 NR 22 TC 107 Z9 108 U1 1 U2 4 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD AUG PY 1993 VL 150 IS 8 BP 1203 EP 1209 PG 7 WC Psychiatry SC Psychiatry GA LP806 UT WOS:A1993LP80600012 PM 8328565 ER PT J AU KITTAYAPONG, P STRICKMAN, D AF KITTAYAPONG, P STRICKMAN, D TI 3 SIMPLE DEVICES FOR PREVENTING DEVELOPMENT OF AEDES-AEGYPTI LARVAE IN WATER JARS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID DENGUE AB We developed three types of covers that are easily fabricated from plastic screen locally manufactured in Thailand. The covers were designed to permit normal use of water jars for drinking, utility water uses, and water storage. Tests of the covers in the laboratory and field demonstrated that they could completely prevent successful development of Aedes aegypti (L.) in water jars. Initial experience in a village setting demonstrated that these devices were readily manufactured and used in a community-based program. Village residents adapted the covers to local patterns of water use, collecting rainwater through the screen and adjusting cover use to water depth. C1 MAHIDOL UNIV,FAC SCI,DEPT BIOL,BANGKOK 10400,THAILAND. USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,DEPT MED ENTOMOL,BANGKOK,THAILAND. NR 11 TC 19 Z9 20 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 1993 VL 49 IS 2 BP 158 EP 165 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LW871 UT WOS:A1993LW87100002 PM 8357077 ER PT J AU EGAN, JE HOFFMAN, SL HAYNES, JD SADOFF, JC SCHNEIDER, I GRAU, GE HOLLINGDALE, MR BALLOU, WR GORDON, DM AF EGAN, JE HOFFMAN, SL HAYNES, JD SADOFF, JC SCHNEIDER, I GRAU, GE HOLLINGDALE, MR BALLOU, WR GORDON, DM TI HUMORAL IMMUNE-RESPONSES IN VOLUNTEERS IMMUNIZED WITH IRRADIATED PLASMODIUM-FALCIPARUM SPOROZOITES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MALARIA VACCINE TRIALS; CD8+ T-CELLS; CIRCUMSPOROZOITE PROTEIN; SURFACE-ANTIGEN; ANTIBODIES; MICE; EFFICACY; GENE; PROTECTION; INHIBITION AB Volunteers immunized with gamma-irradiated Plasmodium falciparum sporozoites serve as the gold standard for protective immunity against mosquito-borne malaria transmission and provide a relevant model for studying protective immune effector mechanisms. During a 7-12-month period, we immunized four volunteers via the bites of irradiated, infected mosquitoes. Following these exposures to attentuated sporozoites, all four volunteers developed antibodies to sporozoites as measured by an immunofluorescence assay and by an enzyme-linked immunosorbent assay using the circumsporozoite (CS) protein repeat-based molecule R32LR as capture antigen. Three volunteers also developed antibodies against the nonrepeating (flanking) regions of the CS protein; the level of these antibodies paralleled the serum activity to inhibit sporozoite invasion of hepatoma cells in vitro. These three volunteers were protected against malaria transmitted by the bites of five infected mosquitoes. Two of these protected volunteers received additional immunizing doses of irradiated sporozoites and were subsequently protected against challenge with a heterologous P. falciparum clone. No detectable fluctuations were observed in circulating levels of tumor necrosis factor, interferon-gamma, or interleukin-6 during the course of this study. Analysis of the humoral and cellular immune responses of these protected volunteers is expected to yield important clues to additional targets of immunity against the pre-erythrocytic stages of malaria parasites. C1 WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. USN,MED RES INST,MALARIA PROGRAM,BETHESDA,MD 20814. UNIV GENEVA,CMU,DEPT PATHOL,CH-1211 GENEVA 4,SWITZERLAND. BIOMED RES INST,ROCKVILLE,MD. RI Grau, Georges/D-7690-2014 OI Grau, Georges/0000-0002-0442-0462 NR 43 TC 99 Z9 99 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 1993 VL 49 IS 2 BP 166 EP 173 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LW871 UT WOS:A1993LW87100003 PM 8357078 ER PT J AU RUSSELL, RG WASSERMAN, SS ODONNOGHUE, JM TAYLOR, DN BOSLEGO, J MORENO, JG HOPKINS, RJ DETOLLA, LJ MORRIS, JG AF RUSSELL, RG WASSERMAN, SS ODONNOGHUE, JM TAYLOR, DN BOSLEGO, J MORENO, JG HOPKINS, RJ DETOLLA, LJ MORRIS, JG TI SEROLOGIC RESPONSE TO HELICOBACTER-PYLORI AMONG CHILDREN AND TEENAGERS IN NORTHERN CHILE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID INFECTION; ASSOCIATION; PREVALENCE; SEROPREVALENCE; GASTRITIS; RISK AB The serologic response to Helicobacter pylori was determined in 388 children and teenagers living in Iquique, Chile by using an IgG enzyme-linked immunosorbent assay. Serum antibody levels, as measured by optical density, correlated strongly with age. Increases in the mean antibody level were seen primarily after age five, with rates of seropositivity increasing to greater-than-or-equal-to 70% among teenagers. The reasons for this age-related pattern of acquisition of infection remain to be determined. C1 UNIV MARYLAND,SCH MED,DEPT PATHOL,BALTIMORE,MD 21201. UNIV MARYLAND,SCH MED,DEPT MED,DIV GEOG MED,BALTIMORE,MD 21201. UNIV MARYLAND,SCH MED,DIV INFECT DIS,BALTIMORE,MD 21201. DEPT VET AFFAIRS MED CTR,BALTIMORE,MD. WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. INST SALUD PUBL CHILE,SANTIAGO,CHILE. RP RUSSELL, RG (reprint author), UNIV MARYLAND,SCH MED,PROGRAM COMPARAT MED,BALTIMORE,MD 21201, USA. NR 14 TC 37 Z9 39 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 1993 VL 49 IS 2 BP 189 EP 191 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LW871 UT WOS:A1993LW87100006 PM 8357081 ER PT J AU DAVIS, JA GREENFIELD, RE BREWER, TG AF DAVIS, JA GREENFIELD, RE BREWER, TG TI BENZOCAINE-INDUCED METHEMOGLOBINEMIA ATTRIBUTED TO TOPICAL APPLICATION OF THE ANESTHETIC IN SEVERAL LABORATORY-ANIMAL SPECIES SO AMERICAN JOURNAL OF VETERINARY RESEARCH LA English DT Article ID CETACAINE; SHEEP AB In a screening study, a common benzocaine-containing anesthetic was topically applied to the following species: dogs (n = 11), domestic shorthair cats (n = 38), Long-Evans rats (n = 22), Sprague-Dawley rats (n = 11), ferrets (n = 6), rhesus monkeys (n = 10), cynomolgus monkeys (n = 10), owl monkeys (n = 10), New Zealand White rabbits (n = 18), miniature pigs (n = 9), ICR mice (n = 4), C3H mice (n = 4), and C57BL/10SnJ mice (n = 24). All animals, except mice and rats, received a 2-second spray to the mucous membranes of the nasopharynx for an estimated dose of 56 mg. A 2-second spray to rodents' oral mucous membranes deliverd too great a volume of fluid for these animals; therefore, an equivalent dose was applied to the oral mucosa membranes by use of a 23-gauge needle and syringe. Initial (baseline) blood samples, as well as 4 blood samples taken every 15 minutes after drug application, were analyzed for methemoglobin (MHb), using an oximeter. Positive MHb response (> 3 SD above baseline) was seen in individuals of all groups. The study was repeated in dogs several months later to confirm low response. Response to benzocaine spray was observed in most animals tested, with response peaking between 15 and 30 minutes after dosing. Positive MHb response ranged from 3.5 to 38%, was detected in > 95% of individual animals, and ranged from 15 to 60 minutes after drug administration. Responses were variable because of the screening nature of the study and the topical route of drug administration, but the highest responses were observed in rabbits and cats, and the lowest were seen in mice and dogs. Methemoglobin could be a confounding variable for several types of studies; investigators should consider this toxicity of benzocaine-containing topical anesthetics and use appropriate alternative methods or drugs (ie, lidocaine). C1 WALTER REED ARMY INST RES,DEPT ANIM RESOURCES,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DIV VET MED,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 16 TC 24 Z9 24 U1 0 U2 1 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 SN 0002-9645 J9 AM J VET RES JI Am. J. Vet. Res. PD AUG PY 1993 VL 54 IS 8 BP 1322 EP 1326 PG 5 WC Veterinary Sciences SC Veterinary Sciences GA LP646 UT WOS:A1993LP64600021 PM 8214904 ER PT J AU WATERHOUSE, WJ ENZENAUER, RW MARTYAK, AP AF WATERHOUSE, WJ ENZENAUER, RW MARTYAK, AP TI SUCCESSFUL STRABISMUS SURGERY IN A CHILD WITH MOEBIUS SYNDROME SO ANNALS OF OPHTHALMOLOGY LA English DT Article AB Moebius syndrome is characterized by congenital paralysis, usually bilateral, of the lateral rectus muscles and the muscles of facial expression. Esotropia is common in these patients. Few reports exist of the surgical results after treatment of strabismus in such patients. We report the case of a 19-month-old white boy with Moebius syndrome who demonstrated an A-pattern esotropia with orthotropia in down-gaze. Use of a conventional surgical approach for an A-pattern esotropia and a bilateral medial rectus recession with a one-half tendon-width supraplacement produced the desired result of orthotropia in primary gaze in our patient. C1 FITZSIMONS ARMY MED CTR,DEPT SURG,OPHTHALMOL SERV,AURORA,CO 80045. TRIPLER ARMY MED CTR,DEPT SURG,OPHTHALMOL SERV,HONOLULU,HI 96859. NR 5 TC 7 Z9 8 U1 0 U2 0 PU AMER SOC CONTEMPORARY OPHTHALMOLOGY PI SKOKIE PA 4711 GOLF RD, SUITE 408, SKOKIE, IL 60076-1242 SN 0003-4886 J9 ANN OPHTHALMOL JI Ann. Ophthalmol. PD AUG PY 1993 VL 25 IS 8 BP 292 EP 294 PG 3 WC Ophthalmology SC Ophthalmology GA LU629 UT WOS:A1993LU62900003 PM 8239323 ER PT J AU VOGELGESANG, SA DENNIS, GJ BAUER, FA AF VOGELGESANG, SA DENNIS, GJ BAUER, FA TI PROTEINURIA ASSOCIATED WITH TOLMETIN TREATMENT IN A PATIENT WITH SYSTEMIC LUPUS-ERYTHEMATOSUS SO ARTHRITIS AND RHEUMATISM LA English DT Item About an Individual RP VOGELGESANG, SA (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD AUG PY 1993 VL 36 IS 8 BP 1181 EP 1182 DI 10.1002/art.1780360822 PG 2 WC Rheumatology SC Rheumatology GA LR486 UT WOS:A1993LR48600021 PM 8343194 ER PT J AU GREEN, MR CHRISTENSEN, KP AF GREEN, MR CHRISTENSEN, KP TI ARTHROSCOPIC VERSUS OPEN BANKART PROCEDURES - A COMPARISON OF EARLY MORBIDITY AND COMPLICATIONS SO ARTHROSCOPY LA English DT Article DE ARTHROSCOPIC BANKART; SHOULDER, ARTHROSCOPIC ADVANTAGES; SHOULDER, SURGERY MORBIDITY; GLENOID LABRUM; SHOULDER, POSTSURGICAL FUNCTION AB Morgan recently reported excellent results by arthroscopically suturing detached labra to the glenoid via drill holes in anterior shoulder dislocators. We attempted to quantitatively compare the operative time, and perioperative morbidity employing this technique to these same parameters using the open Bankart procedure. We retrospectively reviewed the records of consecutive patients undergoing either of these procedures at our institution over the past 2 years. Only those cases wherein the labra were reattached to the glenoid via drill holes were considered. There were 20 patients in the arthroscopic and 18 in the open Bankart groups. Using the arthroscopic method, there was a 1.8-fold decrease in operative time. a 10-fold decrease in blood loss, and a 2.5-fold decrease in postoperative narcotic use compared with the open procedure (p < 0.001). Postoperative fevers were similarly reduced. Hospital stay averaged 3.1 days with the open procedure compared with 1.1 days with the arthroscopic method (p < 0.001). Most arthroscopic Bankarts are now performed on a same-day basis. Time lost from work was 25.5 and 15.3 days for the open and arthroscopic procedures, respectively (p < 0.001). There were three complications among the patients treated with the open technique compared with none in the arthroscopic group. Thus, we conclude that the arthroscopic Bankart procedure offers significant improvements in operative time, perioperative morbidity, and complications compared with the open technique for patients with anterior shoulder instability. RP GREEN, MR (reprint author), TRIPLER ARMY MED CTR,DIV ORTHOPAED SURG,HONOLULU,HI 96859, USA. NR 0 TC 114 Z9 117 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0749-8063 J9 ARTHROSCOPY JI Arthroscopy PD AUG PY 1993 VL 9 IS 4 BP 371 EP 374 DI 10.1016/S0749-8063(05)80308-1 PG 4 WC Orthopedics; Surgery SC Orthopedics; Surgery GA LQ790 UT WOS:A1993LQ79000001 PM 8216566 ER PT J AU RABIN, J AF RABIN, J TI SPATIAL CONTRAST SENSITIVITY THROUGH AVIATORS NIGHT-VISION IMAGING-SYSTEM SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID CHART AB Visual acuity is often used to assess vision through image intensifying devices such as night vision goggles (NVG's). Fewer attempts have been made to measure contrast sensitivity through NVG's. Such information would be useful to better understand contrast processing through NVG's under various stimulus conditions. In this study, computer-generated letter charts were used to measure contrast sensitivity through third generation NVG's for a range of letter sizes. The red phosphor of a standard color monitor proved to be an effective stimulus for third generation devices. Different night sky conditions were simulated over a 3 log unit range. The results illustrate the profile of contrast sensitivity through third generation NVG's over a range of night sky conditions. Comparison of measurements through NVG's to measurements obtained without the device but at the same luminance and color distinguish between effects of luminance and noise on contrast sensitivity. RP RABIN, J (reprint author), USA,AEROMED RES LAB,DIV SENSORY RES,POB 620577,FT RUCKER,AL 36362, USA. NR 15 TC 8 Z9 8 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 1993 VL 64 IS 8 BP 706 EP 710 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA LP566 UT WOS:A1993LP56600004 PM 8368983 ER PT J AU BRUCKART, JE MCENTIRE, J LICINA, JR BRANTLEY, DK SHANAHAN, DF AF BRUCKART, JE MCENTIRE, J LICINA, JR BRANTLEY, DK SHANAHAN, DF TI FATAL MISHAP REPORT - 1ST SPH-4B FLIGHT HELMET RECOVERED FROM A UNITED-STATES-ARMY HELICOPTER MISHAP SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Note AB The most common cause of death in helicopter accidents is head injury. Flight helmets can be designed to distribute and attenuate crash forces to the head. Experience derived from crashes using the U.S. Army SPH-4 flight helmet has led to modifications to improve protection. Within the past year, the Army has introduced the SPH-4B flight helmet which includes several new features to reduce injury in future mishaps. The first SPH-4B flight helmet recovered from a fatal mishap is described and correlated with the injuries to the wearer. The new shell and liner reduced the impact forces to the head. There were no side impacts to determine the performance of the crushable earcups in the helmet. The new SPH-4B flight helmet has several new and distinctive features that should improve survival in future helicopter crashes. careful study of life support equipment retrieved from crashes is important to understand how the equipment performs in the crash environment. RP BRUCKART, JE (reprint author), USA,AEROMED RES LAB,DIV BIODYNAM RES,LIFE SUPPORT EQUIPMENT BRANCH,POB 577,FT RUCKER,AL 36362, USA. NR 16 TC 1 Z9 1 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 1993 VL 64 IS 8 BP 755 EP 759 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA LP566 UT WOS:A1993LP56600012 PM 8368991 ER PT J AU CASTEEL, DA PERI, SP GERENA, L AF CASTEEL, DA PERI, SP GERENA, L TI SYNTHESIS AND ANTIMALARIAL EVALUATION OF 2,3,5-TRIOXABICYCLO[2.2.3]NONANE, A MODEL FOR THE PUTATIVE PHARMACOPHORE OF ARTEMISININ SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article ID QINGHAOSU ARTEMISININ AB The title compound was prepared from the known 6-tetrahydrooxepanol by formation of the 6-mesylate followed by treatment with acidic methanol to yield the methyl acetal. Reaction of 2-methoxy-6-mesyloxytetrahydrooxepane with anhydrous hydrazine followed by treatment with 30 hydrogen peroxide and sodium peroxide provided the diastereomeric mixture of 6-hydroperoxides. The hydroperoxides cyclized upon treatment with acid to give trioxabicyclo[2.2.3]bicyclononane. The bridged bicyclic trioxane exhibited only marginal antimalarial activity. C1 WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP CASTEEL, DA (reprint author), UNIV IOWA,COLL PHARM,DIV MED & NAT PROD CHEM,IOWA CITY,IA 52242, USA. NR 8 TC 7 Z9 7 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD AUG PY 1993 VL 3 IS 8 BP 1707 EP 1710 DI 10.1016/S0960-894X(00)80047-5 PG 4 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA LW592 UT WOS:A1993LW59200045 ER PT J AU ZHANG, TM YANG, ZQ ZHANG, MY HU, ZJ XIANG, JM HUGGINS, JW COSGRIFF, TM SMITH, JI AF ZHANG, TM YANG, ZQ ZHANG, MY HU, ZJ XIANG, JM HUGGINS, JW COSGRIFF, TM SMITH, JI TI EARLY ANALYSIS OF VIREMIA AND CLINICAL-TESTS IN PATIENTS WITH EPIDEMIC HEMORRHAGIC-FEVER SO CHINESE MEDICAL JOURNAL LA English DT Article AB We analysed the early viremia and clinical tests in 82 patients with epidemic hemorrhagic fever (EHF). The results showed that the changes in viremia and clinical tests are related to the severity of the disease and prognosis. Higher concentrations of the virus in infected patients might cause a more unfavourable prognosis and more abnormalities in clinical tests. CK-MB, SGOT, SGPT, serum creatinine and urea nitrogen contents increased markedly, while serum total protein, albumin and calcium contents decreased markedly, indicating that the heart, liver and kidney in EHF patients were severely damaged. Markedly increased WBC and monocytes showed that the patients were seriously infected. Platelet count, antithrombin-III and plasminogen decreased markedly, demonstrating that there were marked changes in the coagulation-anticoagulation and fibrinolytic system of the EHF patients. Changes in RBC, Hb and HCT contents indicated that the blood in the EHF patients had a higher concentration. This study gives further evidence that EHFV plays an important role in the pathogenesis of EHF. C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD. RP ZHANG, TM (reprint author), HUBEI MED COLL,VIRUS RES INST,WUHAN 430071,PEOPLES R CHINA. NR 5 TC 3 Z9 3 U1 0 U2 0 PU CHINESE MEDICAL ASSOCIATION PI BEIJING PA 42 DONGSI XIDAJIE, BEIJING 100710, PEOPLES R CHINA SN 0366-6999 J9 CHINESE MED J-PEKING JI Chin. Med. J. PD AUG PY 1993 VL 106 IS 8 BP 608 EP 610 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA LX847 UT WOS:A1993LX84700011 PM 7900974 ER PT J AU OLAUGHLIN, MP SLACK, MC GRIFKA, RG PERRY, SB LOCK, JE MULLINS, CE AF OLAUGHLIN, MP SLACK, MC GRIFKA, RG PERRY, SB LOCK, JE MULLINS, CE TI IMPLANTATION AND INTERMEDIATE-TERM FOLLOW-UP OF STENTS IN CONGENITAL HEART-DISEASE SO CIRCULATION LA English DT Article DE PULMONARY ARTERY; DILATION; VEINS; STENOSIS; ANGIOPLASTY AB Background. Balloon-expandable stents (johnson and Johnson Interventional Systems) have been in use for congenital heart disease since late 1989. They have made possible treatment in previously untreatable branch pulmonary artery stenoses and systemic venous stenosis. The purpose of this report is to detail the results and intermediate-term follow-up of stents used for treatment of congenital heart disease. Methods and Results. Eighty-five patients underwent placement of 121 stents in Houston and Boston. Fifty-eight patients had stents put in pulmonary arteries, nine had stents in conduits or outflow tracts, and 21 had stents in venous stenoses or narrowed Fontan anastomoses. (Three patients had stents in two locations.) These stent procedures resulted in gradient reduction from 55.2 +/- 33.3 to 14.2 +/- 13.5 mm Hg in pulmonary arteries, from 41.4 +/- 26.0 to 20.7 +/- 17.0 mm Hg in conduits or outflow tracts, and from 9.8 +/- 6.9 to 2.4 +/- 3.1 mm Hg in venous stenoses or Fontan anastomoses. Diameter of narrowings increased from 4.6 +/- 2.3 to 11.3 +/- 3.2 mm in the pulmonary artery, from 8.8 +/- 3.6 to 12.7 +/- 2.6 in conduits, and from 3.8 +/- 2.9 to 11.3 +/- 2.8 in venous stenoses. Follow-up has shown stent fracture in one patient, restenosis in one, and sudden death in one. Recatheterization has been done in 38 patients an average of 8.6 months after stent installation. Compared with immediately postimplant data, there was no significant change in luminal diameter or pressure gradient. Redilation was performed in 14 patients (17 stents) 1 week to 24 months after implantation (mean, 10.2 months), with a small but significant increase in stenosis diameter. Conclusions. We conclude that stent treatment of vascular stenoses in congenital heart disease retains efficacy at medium-term follow-up and offers a much-improved outlook for patients with these lesions. C1 TEXAS CHILDRENS HOSP,DIV PEDIAT CARDIOL,HOUSTON,TX 77030. TEXAS CHILDRENS HOSP,DIV PEDIAT,HOUSTON,TX 77030. WALTER REED ARMY MED CTR,CARDIOL SERV,WASHINGTON,DC 20307. BOSTON CHILDRENS HOSP,DEPT PEDIAT CARDIOL,BOSTON,MA. RP OLAUGHLIN, MP (reprint author), DUKE UNIV,DIV PEDIAT CARDIOL,POB 3090,DURHAM,NC 27710, USA. NR 3 TC 227 Z9 235 U1 1 U2 2 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD AUG PY 1993 VL 88 IS 2 BP 605 EP 614 PG 10 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA LR058 UT WOS:A1993LR05800033 PM 8339424 ER PT J AU BECKER, JA ASCHER, DP MENDIOLA, J YODER, B WEISSE, M WAECKER, N HEROMAN, WM DAVIS, C FAJARDO, JE FISCHER, GW AF BECKER, JA ASCHER, DP MENDIOLA, J YODER, B WEISSE, M WAECKER, N HEROMAN, WM DAVIS, C FAJARDO, JE FISCHER, GW TI FALSE-NEGATIVE URINE LATEX PARTICLE AGGLUTINATION TESTING IN NEONATES WITH GROUP-B STREPTOCOCCAL BACTEREMIA - A FUNCTION OF IMPROPER TEST IMPLEMENTATION SO CLINICAL PEDIATRICS LA English DT Article ID RAPID DIAGNOSIS; BODY-FLUIDS; ANTIGEN; INFECTION; ASSAY AB Although blood cultures remain the most specific indicator of Group B streptococcus (GBS) sepsis, a potentially life-threatening infection in neonates, test results may not be available for 24 to 48 hours. Detection of GBS antigen in the urine by latex particle agglutination (LPA) may speed diagnosis. This study analyzed the sensitivity of the GBS urine LPA assay under clinical conditions. The urine of neonates with early-onset GBS bacteremia was analyzed for GBS antigen over a three-year period at six military medical centers. Overall, 53.5% (38/71) of infants with positive blood cultures had a positive urine LPA test. Only one medical center routinely followed manufacturer's recommendations to concentrate urine specimens before testing. These data suggest that the sensitivity for the urine LPA assay, when performed on unconcentrated urine, is lower than previously reported. Clinicians should insist that the laboratory maximize sensitivity by concentrating urine prior to GBS LPA testing. C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236. TRIPLER ARMY MED CTR,OAHU,HI. USN HOSP,SAN DIEGO,CA 92134. USN HOSP,PORTSMOUTH,VA. NR 8 TC 6 Z9 6 U1 0 U2 0 PU WESTMINSTER PUBL INC PI GLEN HEAD PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD AUG PY 1993 VL 32 IS 8 BP 467 EP 471 DI 10.1177/000992289303200805 PG 5 WC Pediatrics SC Pediatrics GA LT005 UT WOS:A1993LT00500005 PM 8403745 ER PT J AU ALIABADI, SK TEZDUYAR, TE AF ALIABADI, SK TEZDUYAR, TE TI SPACE-TIME FINITE-ELEMENT COMPUTATION OF COMPRESSIBLE FLOWS INVOLVING MOVING BOUNDARIES AND INTERFACES SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article ID ADVECTIVE-DIFFUSIVE SYSTEMS; FLUID-DYNAMICS; FORMULATION; CYLINDERS; EQUATIONS; STRATEGY; OPERATOR; EULER AB The deformable-spatial-domain / stabilized-space-time (DSD/SST) formulation, introduced by Tezduyar et al. is applied to computation of viscous compressible flows involving moving boundaries and interfaces. The stabilization technique employed is a streamline-upwind / Petrov-Galerkin (SUPG) method, with a modified SUPG stabilization matrix. The stabilized finite element formulation of the governing equations is written over the space-time domain of the problem, and therefore the deformation of the spatial domain with respect to time is taken into account automatically. The frequency of remeshing is minimized to minimize the projection errors involved in remeshing and also to increase the parallelization potential of the computations. The implicit equation systems arising from the space-time finite element discretizations are solved iteratively. It is demonstrated that the combination of the SUPG stabilization and the space-time approach gives the capability of handling complicated compressible flow problems, including those with moving surfaces and shock-boundary layer interactions. C1 UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,1200 WASHINGTON AVE S,MINNEAPOLIS,MN 55415. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,DEPT AEROSP ENGN & MECH,MINNEAPOLIS,MN 55415. RI Tezduyar, Tayfun/F-6134-2012 OI Tezduyar, Tayfun/0000-0001-8707-3162 NR 14 TC 68 Z9 70 U1 0 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0045-7825 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD AUG PY 1993 VL 107 IS 1-2 BP 209 EP 223 DI 10.1016/0045-7825(93)90176-X PG 15 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA LR193 UT WOS:A1993LR19300011 ER PT J AU BIRX, DL REDFIELD, RR AF BIRX, DL REDFIELD, RR TI IMMUNOTHERAPEUTIC STRATEGIES IN THE TREATMENT OF HIV-INFECTION AND AIDS SO CURRENT OPINION IN IMMUNOLOGY LA English DT Review ID HUMAN-IMMUNODEFICIENCY-VIRUS; PASSIVE-IMMUNIZATION; RECOMBINANT GP160; TYPE-1 INFECTION; PERIPHERAL-BLOOD; CONTROLLED TRIAL; T-CELLS; VACCINE; PLASMA; INDIVIDUALS AB The immune response against HIV does not result in complete viral clearance. Recent interventions have focused on novel strategies to modify human anti-HIV immunity. Active vaccination of patients with HIV infection (vaccine therapy) safely alters the immune repertoire against HIV. This unique approach will provide insight into the immunoregulatory consequences of HIV-specific innate and adaptive immune responses, and hopefully define the immunological Achilles heel of HIV. Once defined, researchers, aided by current biotechnological techniques, can rationally design future vaccines and immune based therapeutic products. RP BIRX, DL (reprint author), WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,WASHINGTON,DC 20307, USA. NR 47 TC 7 Z9 7 U1 0 U2 0 PU CURRENT BIOLOGY LTD PI LONDON PA 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB SN 0952-7915 J9 CURR OPIN IMMUNOL JI Curr. Opin. Immunol. PD AUG PY 1993 VL 5 IS 4 BP 600 EP 607 DI 10.1016/0952-7915(93)90044-S PG 8 WC Immunology SC Immunology GA LU975 UT WOS:A1993LU97500020 PM 8216935 ER PT J AU DEMERS, DM VINCENT, JM BASS, JW AF DEMERS, DM VINCENT, JM BASS, JW TI GROUP-A STREPTOCOCCAL DISEASE SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Article AB With the decline in incidence of severe disease due to group A beta-hemolytic streptococci (GABHS) in developed countries over the past 4 decades most young clinicians have little experience with highly fatal diseases once associated with this organism. More recent reports, however, indicate that the epidemiology of GABHS disease has been changing over the past several years and severe disease is remerging. This review will focus on some of these changes and related developments; specifically, streptococcal pyoderma, streptococcal antigen detection kits, acute rheumatic fever and severe invasive streptococcal disease. RP DEMERS, DM (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,POB 330,HONOLULU,HI 96859, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0951-7375 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD AUG PY 1993 VL 6 IS 4 BP 565 EP 569 DI 10.1097/00001432-199308000-00014 PG 5 WC Infectious Diseases SC Infectious Diseases GA LQ292 UT WOS:A1993LQ29200015 ER PT J AU VUKELJA, SJ SHARKEY, MJ BAKER, WJ BERGER, TC AF VUKELJA, SJ SHARKEY, MJ BAKER, WJ BERGER, TC TI PERICARDITIS ASSOCIATED WITH ACRAL ERYTHEMA OF CHEMOTHERAPY - A SYNDROME OF CUTANEOUS AND SEROSAL TOXICITIES SO CUTIS LA English DT Article ID BONE-MARROW TRANSPLANTATION AB A nineteen-year-old woman whose Hodgkin's disease had relapsed experienced acral erythema in association with an asymptomatic pericardial friction rub following autologous bone marrow transplantation. An echocardiogram revealed a large pericardial and right pleural effusion. Since blood cultures gave negative results, renal function was normal, and the patient had neither neutropenia nor elevated temperature, an infectious cause was deemed unlikely and invasive procedures were not performed. These effusions resolved spontaneously. We propose that this patient's acral erythema and associated pericardial and pleural inflammation represent cutaneous and serosal toxic reactions to high-dosage chemotherapy that occur with the onset of leukocyte recovery. If so, acral erythema may signal the beginning of a toxic drug reaction. The appearance of erythema associated with lymphocyte recovery is due to immune hypersensitivity secondary to immaturity of the reconstituting immune system. Thus, we recommend that patients with acral erythema be examined for pleuropericarditis, especially if they experience chest pain. C1 BROOKE ARMY MED CTR,DEPT MED,GRAD SCH HEMATOL ONCOL,FT SAM HOUSTON,TX 78234. NR 6 TC 2 Z9 2 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD AUG PY 1993 VL 52 IS 2 BP 89 EP 90 PG 2 WC Dermatology SC Dermatology GA PK217 UT WOS:A1993PK21700006 PM 8404022 ER PT J AU CARR, FE REID, AH WESSENDORF, MW AF CARR, FE REID, AH WESSENDORF, MW TI A CRYPTIC PEPTIDE FROM THE PREPROTHYROTROPIN-RELEASING HORMONE PRECURSOR STIMULATES THYROTROPIN GENE-EXPRESSION SO ENDOCRINOLOGY LA English DT Article ID PITUITARY-TUMOR CELLS; PROLACTIN GENE; MESSENGER-RNA; RAT-BRAIN; GROWTH-HORMONE; TRH; TRANSCRIPTION; PROHORMONE; IDENTIFICATION; CALCIUM AB The precursor peptide of TRH (prepro-TRH) contains five copes of pro-TRH linked by other peptide sequences. These peptides are coprocessed with TRH in the median eminence of the hypothalamus and released into the portal circulation, rendering this family of peptides available to act at the level of the anterior pituitary. Therefore, we tested the potential bioactivity of one cryptic peptide, prepro-TRH amino acids 160-169 [prepro-TRH-(160-169)], in a TRH-responsive pituitary cell line (GH3). In a heterologous TSH expression assay, we found that prepro-TRH-(160-169) stimulated TSHbeta gene promoter activity in a time- and dose-dependent manner; moreover, the effect of prepro-TRH-(160-169) was more rapid and of greater magnitude than that of TRH on TSHbeta-directed chloramphenicol acetyltransferase synthesis. In the same cells, we found that prepro-TRH-(160-169) stimulated PRL synthesis and secretion, but the effect was similar in magnitude and duration to that of TRH. The effect of prepro-TRH-(160-169) appears to be additive to that of TRH, suggesting that prepro-TRH-(160-169) may act through a mechanism separate from that of TRH. Thus, prepro-TRH-(160-169) has potent endocrinological effects at the level of the genome. C1 WALTER REED ARMY INST RES, DEPT CLIN PHYSIOL, WASHINGTON, DC 20307 USA. UNIV MINNESOTA, DEPT CELL BIOL & NEUROANAT, MINNEAPOLIS, MN 55455 USA. RP CARR, FE (reprint author), WALTER REED ARMY MED CTR, DEPT CLIN INVEST, KYLE METAB UNIT, 6800 GEORGIA AVE, WASHINGTON, DC 20307 USA. NR 27 TC 23 Z9 23 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0013-7227 EI 1945-7170 J9 ENDOCRINOLOGY JI Endocrinology PD AUG PY 1993 VL 133 IS 2 BP 809 EP 814 DI 10.1210/en.133.2.809 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA LQ846 UT WOS:A1993LQ84600053 PM 8344217 ER PT J AU PARMELEE, RW WENTSEL, RS PHILLIPS, CT SIMINI, M CHECKAI, RT AF PARMELEE, RW WENTSEL, RS PHILLIPS, CT SIMINI, M CHECKAI, RT TI SOIL MICROCOSM FOR TESTING THE EFFECTS OF CHEMICAL-POLLUTANTS ON SOIL FAUNA COMMUNITIES AND TROPHIC STRUCTURE SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE NEMATODES; MICROARTHROPODS; COPPER; P-NITROPHENOL; TRINITROTOLUENE ID EARTHWORM EISENIA-FETIDA; NO-TILLAGE AGROECOSYSTEMS; ORGANIC-CHEMICALS; SEWAGE-SLUDGE; HEAVY-METALS; TOXICITY; DECOMPOSITION; NEMATODES; LITTER; MICROARTHROPODS AB A microcosm technique is presented that uses community and trophic-level analysis of soil nematodes and microarthropods to determine the effects of chemicals on soil systems. Forest soil was treated with either copper (0, 100, 200, 400, and 600 mug g-1), p-nitrophenol (0, 20, 40, 80, and 160 mug g-1), or trinitrotoluene (0, 25, 50, 100, and 200 mug g-1). Nematodes were sorted into bacterivore, fungivore, herbivore, and omnivore-predator trophic groups, and a hatchling category. Microarthropods were sorted to the acarine suborders Prostigmata, Mesostigmata, and Oribatida; the insectan order Collembola; and a miscellaneous group. Omnivore-predator nematodes and meso-stigmatid and oribatid mites were the groups most sensitive to copper and were significantly reduced at levels as low as 100 mug g-1 copper. Total nematode and microarthropod numbers declined above 200 mug g-1 copper. Trophic structure analysis suggested that high sensitivity of nematode predators to intermediate levels of copper reduced predation on herbivore nematodes and resulted in greater numbers of nematodes compared to controls. p-Nitrophenol was very toxic to the nematode community, and all trophic groups were significantly reduced above 20 mug g-1. However, there was no effect of p-nitrophenol on microarthropods. Trinitrotoluene had no significant negative effect on total abundance of either group of soil fauna, but oribatids were significantly reduced at 200 mug g-1. Our results demonstrated that soil nematodes and microarthropods were sensitive indicators of environmental contaminants and that trophic-structure and community analysis has the potential to detect more subtle indirect effects of chemicals on soil food-web structure. We conclude that microcosms with field communities of soil microfauna offer high resolution of the ecotoxicological effects of chemicals in complex soil systems. C1 USA,CRDEC,ABERDEEN PROVING GROUND,MD 21010. GEOCENTERS INC,ABERDEEN PROVING GROUND,MD 21010. RP PARMELEE, RW (reprint author), OHIO STATE UNIV,DEPT ENTOMOL,1735 NEIL AVE,COLUMBUS,OH 43210, USA. NR 45 TC 80 Z9 84 U1 5 U2 30 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD AUG PY 1993 VL 12 IS 8 BP 1477 EP 1486 DI 10.1897/1552-8618(1993)12[1477:SMFTTE]2.0.CO;2 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA LP260 UT WOS:A1993LP26000015 ER PT J AU HONIG, PK WORTHAM, DC ZAMANI, K CONNER, DP MULLIN, JC CANTILENA, LR AF HONIG, PK WORTHAM, DC ZAMANI, K CONNER, DP MULLIN, JC CANTILENA, LR TI EFFECT OF CONCOMITANT ADMINISTRATION OF CIMETIDINE AND RANITIDINE ON THE PHARMACOKINETICS AND ELECTROCARDIOGRAPHIC EFFECTS OF TERFENADINE SO EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article DE TERFENADINE METABOLISM; CIMETIDINE; RANITIDINE; ANTIHISTAMINES; TORSADES-DE-POINTES; PHARMACOKINETICS; DRUG INTERACTION ID DRUG-INTERACTIONS; ERYTHROMYCIN AB Terfenadine is a widely prescribed non-sedating antihistamine which undergoes rapid and almost complete first pass biotransformation to an active carboxylic acid metabolite. It is unusual to find unmetabolised terfenadine in the plasma of patients taking the drug. Terfenadine in vitro is a potent blocker of the myocardial potassium channel. Overdose, hepatic compromise and the coadministration of ketoconazole and erythromycin result in the accumulation of terfenadine, which is thought to be responsible of QT prolongation and Torsades de Pointes ventricular arrhythmia in susceptible individuals. Cimetidine and ranitidine are two popular H-2 antagonists which are often taken with terfenadine. The effects of cimetidine and ranitidine on terfenadine metabolism were studied in two cohorts of 6 normal volunteers given the recommended dose of terfenadine (60 mg every 12 h) for 1 week prior to initiation of cimetidine 600 mg every 12 h or ranitidine 150 mg every 12 h. Pharmacokinetic profiles and morning pre-dose electrocardiograms were obtained whilst the patients were on terfenadine alone and after the addition of cimetidine or rantidine. One of the subjects in each cohort had a detectable plasma level of parent compound after 1 week of terfenadine therapy alone; it did not accumulate further after addition of the H-2 antagonist. The pharmacokinetics of the carboxylic acid metabolite of terfenadine (C(max), t(max), AUC) were not significantly changed after co-administration of either H-2 antagonist. None of the remaining 5 subjects in either cohort demonstrated accumulation of unmetabolised terfenadine after addition of the respective H-2 antagonist and electrocardiographic QT intervals and T-U morphology in them was not changed during the course of the study. We conclude that cimetidine and ranitidine in the dosages used in this study did not affect the metabolism of terfenadine, and that patients exposed to these drug combinations are not at increased risk of altered cardiac repolarisation. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL,DIV CLIN PHARMACOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT CARDIOL,WASHINGTON,DC 20307. US FDA,ROCKVILLE,MD 20857. RI Zamani, Kaveh/A-9182-2011 NR 28 TC 24 Z9 25 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0031-6970 J9 EUR J CLIN PHARMACOL JI Eur. J. Clin. Pharmacol. PD AUG PY 1993 VL 45 IS 1 BP 41 EP 46 DI 10.1007/BF00315348 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA LR694 UT WOS:A1993LR69400007 PM 8405028 ER PT J AU MADDEN, KB MOELLER, RF DOUGLASS, LW GOLDMAN, T LUNNEY, JK AF MADDEN, KB MOELLER, RF DOUGLASS, LW GOLDMAN, T LUNNEY, JK TI TRICHINELLA-SPIRALIS - GENETIC-BASIS AND KINETICS OF THE ANTI-ENCYSTED MUSCLE LARVAL RESPONSE IN MINIATURE SWINE SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE HELMINTH; TRICHINELLA-SPIRALIS; T-CELL RESPONSES; EOSINOPHILS; HISTOCHEMISTRY; NIH MINIPIG; ENCYSTED MUSCLE LARVAE (ML); MAJOR HISTOCOMPATIBILITY COMPLEX (MHC); SWINE LEUKOCYTE ANTIGEN (SLA) COMPLEX; AX, PIGS WITH SLA HAPLOTYPES AA, AC, AD, AF, AG, DH, AND HH; NON-AX, PIGS WITH SLA HAPLOTYPES CC, CD, AND DD; GENETIC REGULATION; DISEASE RESISTANCE; NURSE CELLS; RESPONDER (R); NONRESPONDER (NR); PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC); MESENTERIC LYMPH NODE CELLS (MLNC); MANDIBULAR LYMPH NODE CELLS (MDLNC); RETROPHARYNGEAL LYMPH NODE CELLS (RPLNC); CRUDE WORM EXTRACT (CWE); INTERLEUKIN (IL); INTERFERON (IFN) ID MAJOR HISTOCOMPATIBILITY COMPLEX; CELL SUBSETS; RESISTANCE; MICE; INFECTION; EOSINOPHILS; SUSCEPTIBILITY; DESTRUCTION; SECRETION; IMMUNITY C1 USDA ARS,BELTSVILLE AGR RES CTR,LPSI,HELMINTH DIS LAB,BELTSVILLE,MD 20705. WALTER REED ARMY MED CTR,ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. UNIV MARYLAND,DEPT ANIM SCI,COLL PK,MD 20742. NR 36 TC 15 Z9 16 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD AUG PY 1993 VL 77 IS 1 BP 23 EP 35 DI 10.1006/expr.1993.1057 PG 13 WC Parasitology SC Parasitology GA LR331 UT WOS:A1993LR33100003 PM 8344404 ER PT J AU BRANDT, HE AF BRANDT, HE TI SPACETIME TANGENT BUNDLE WITH TORSION SO FOUNDATIONS OF PHYSICS LETTERS LA English DT Article DE SPACETIME TANGENT BUNDLE; FINSLER SPACETIME; KAHLER MANIFOLD; TORSION; GAUGE CURVATURE FIELD; ALMOST COMPLEX STRUCTURE AB It is demonstrated explicitly that the bundle connection of the Finsler-spacetime tangent bundle can be made compatible with Cartan's theory of Finsler space by the inclusion of bundle torsion, and without the restriction that the gauge curvature field be vanishing. A component of the contorsion is made to cancel the contribution of the gauge curvature field to the relevant component of the bundle connection. Also, it is shown that the bundle manifold remains almost complex, and that the almost complex structure can be made to have a vanishing covariant derivative if additional conditions on the torsion are satisfied. However, the Finsler-spacetime tangent bundle remains complex only if the gauge curvature field vanishes. RP BRANDT, HE (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0894-9875 J9 FOUND PHYS LETT JI Found. Phys. Lett. PD AUG PY 1993 VL 6 IS 4 BP 339 EP 369 DI 10.1007/BF00665653 PG 31 WC Physics, Multidisciplinary SC Physics GA LX627 UT WOS:A1993LX62700005 ER PT J AU BECKER, RL SPECHT, CS JONES, R RUEDAPEDRAZA, ME OLEARY, TJ AF BECKER, RL SPECHT, CS JONES, R RUEDAPEDRAZA, ME OLEARY, TJ TI USE OF REMOTE VIDEO MICROSCOPY (TELEPATHOLOGY) AS AN ADJUNCT TO NEUROSURGICAL FROZEN-SECTION CONSULTATION SO HUMAN PATHOLOGY LA English DT Article ID NORWAY C1 ARMED FORCES INST PATHOL,DEPT CELLULAR PATHOL,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,DEPT NEUROPATHOL,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,DEPT OPHTHALM PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 6 TC 48 Z9 48 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0046-8177 J9 HUM PATHOL JI Hum. Pathol. PD AUG PY 1993 VL 24 IS 8 BP 909 EP 911 DI 10.1016/0046-8177(93)90142-4 PG 3 WC Pathology SC Pathology GA LT274 UT WOS:A1993LT27400013 PM 8375860 ER PT J AU YUAN, CM MANUNTA, P HAMLYN, JM CHEN, S BOHEN, E YEUN, J HADDY, FJ PAMNANI, MB AF YUAN, CM MANUNTA, P HAMLYN, JM CHEN, S BOHEN, E YEUN, J HADDY, FJ PAMNANI, MB TI LONG-TERM OUABAIN ADMINISTRATION PRODUCES HYPERTENSION IN RATS SO HYPERTENSION LA English DT Article DE OUABAIN; HYPERTENSION, RENAL; NA+,K+-ATPASE; SODIUM-POTASSIUM PUMP ID DIGITALIS-LIKE-FACTOR; POTASSIUM-ADENOSINE-TRIPHOSPHATASE; HUMAN-PLASMA; CIRCULATING INHIBITOR; SODIUM-TRANSPORT; BLOOD-PRESSURE; IDENTIFICATION; VOLUME; PUMP; COMPOUND AB Ouabain has recently been identified as an endogenous Na+-K+ pump inhibitor. We administered ouabain chronically to normotensive rats with varying degrees of reduced renal mass (RRM) and to normal two-kidney rats to see whether hypertension could be produced. Normal male Wistar rats and rats with 25%, 60%, and 70% RRM received ouabain (13.9 mug/kg per day IP) in normal saline for 4 weeks followed by ouabain (27.8 mug/kg per day IP) for 3 to 4 more weeks. Respective control animals received vehicle only. Blood pressure was recorded weekly by tail plethysmography. Animals received tap water and standard rat chow, except for 70% RRM rats, which received distilled water and sodium-free chow. After 6 to 8 weeks of treatment, with rats under thiobutabarbital anesthesia, direct blood pressure was determined. Plasma, tissue, and urinary ouabain levels were measured with a specific radioimmunoassay. Animals receiving ouabain developed significant in creases in mean blood pressure compared with control animals (70% RRM, 147 +/- 4; vs 116 +/- 4 mm Hg; 60% RRM, 140 +/- 4 vs 107 +/- 3 mm Hg; 25% RRM, 13 +/- 5 vs 100 +/- 2 mm Hg; no RRM, 116 +/- 4 vs 98 +/- 5 mm Hg). Plasma ouabain levels measured 24 hours after the last ouabain dose were not different in animals receiving ouabain vs those receiving vehicle. However, kidney tissue ouabain levels were significantly greater (6.39 +/- 1.17 vs 2.36 +/- 0.52 mug/kg, P < .05) in animals receiving ouabain. In conclusion, ouabain, given chronically, is associated with the development of hypertension in RRM rats as well as in normal rats. Blood pressure was greater in animals with greater degrees of RRM for a given ouabain dose. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. UNIV MARYLAND,DEPT PHYSIOL,BALTIMORE,MD 21201. RP YUAN, CM (reprint author), WALTER REED ARMY MED CTR,DEPT MED,NEPHROL SERV,WASHINGTON,DC 20307, USA. NR 51 TC 136 Z9 142 U1 0 U2 1 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0194-911X J9 HYPERTENSION JI Hypertension PD AUG PY 1993 VL 22 IS 2 BP 178 EP 187 PG 10 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA LQ645 UT WOS:A1993LQ64500007 PM 8340153 ER PT J AU SCHIAVONE, GA ONEILL, K PAULSEN, KD AF SCHIAVONE, GA ONEILL, K PAULSEN, KD TI H-POLARIZED SCATTERING FROM SINGLE AND MULTIPLE ELONGATED CAVITIES SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article ID ELECTROMAGNETIC TRANSMISSION; CONDUCTING PLANE; GROUND PLANE; APERTURE; FORMULATION; SURFACES; SLIT AB H-polarized scattering is investigated for perfectly conducting surfaces containing one, two, or many parallel grooves. Incidence is transverse to the axes of the cavities, which are of rectangular cross section and on the order of the incident wavelength in size. For cases with many regularly spaced cavities, a Floquet and waveguide, mode-matching scheme is used that incorporates the effects of a nonplanar, nonuniform incident beam, a corresponding receiving pattern, and a finite target size. Realistic simplification of the receiving pattern greatly reduces the computational requirements for the case of backscatter. For single grooves, point matching is used between waveguide mode and integral expressions. Measured backscatter patterns show negligible coupling effects for two nearby cavities; thus, pattern multiplication using single-cavity patterns is applied to obtain results for dual-cavity structures. Calculated patterns for single-cavity and multiple-cavity targets agree well with Ka-band laboratory measurements. The results highlight the significance of the finite beam and lab setting in surface scattering studies, and show grating type behavior for two or more scattering cavities. Parametric studies and spectral analysis for multiple-cavity structures suggest an ability to estimate individual cavity width and separation for sets of similar cavities, and to estimate cavity separation even for dissimilar cavities. C1 USA,COLD REGIONS RES & ENGN LAB,HANOVER,NH 03755. RP SCHIAVONE, GA (reprint author), DARTMOUTH COLL,THAYER SCH ENGN,HANOVER,NH 03755, USA. NR 24 TC 4 Z9 4 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD AUG PY 1993 VL 41 IS 8 BP 1122 EP 1131 DI 10.1109/8.244654 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA MH961 UT WOS:A1993MH96100015 ER PT J AU CHANH, TC HEWETSON, JF AF CHANH, TC HEWETSON, JF TI POLYCLONAL ANTIIDIOTYPES INDUCE ANTIBODY-RESPONSES PROTECTIVE AGAINST RICIN CYTOTOXICITY SO IMMUNOLOGY LA English DT Note ID COMMUNIS; VACCINE; INVITRO AB Protein G-purified goat anti-ricin IgG, previously demonstrated to protect against ricin toxicity in vitro and in vivo, was used to raise BALB/c mouse and New Zealand White rabbit polyclonal anti-idiotypic antibodies. The generated anti-idiotypic sera were repeatedly absorbed over agarose conjugated to normal goat immunoglobulins, and purified by protein A-agarose affinity chromatography. Immunization of BALB/c mice with BALB/c anti-idiotypes did not result in a significant anti-ricin antibody response. However, injection of BALB/c mice with BALB/c anti-idiotypes conjugated to keyhole limpet haemocyanin (KLH) or with unconjugated rabbit anti-idiotypes resulted in specific and anti-ricin immune responses. The anti-idiotype-induced anti-ricin antibody responses protected against the in vitro cytotoxicity of ricin, a potent plant-derived protein synthesis inhibitor, as assessed by the murine EL-4 leukaemia cell assays. Thus, anti-idiotype-based vaccines may represent an alternative, safe and effective means of inducing protective immunity against toxins such as ricin, whose extreme in vivo toxicity render them unsafe as immunogens. C1 SW FDN BIOMED RES,CTR AIDS RES,SAN ANTONIO,TX 78228. USA,INFECT DIS RES INST,DEPT PATHOPHYSIOL,FREDERICK,MD 21701. RP CHANH, TC (reprint author), SW FDN BIOMED RES,DEPT VIROL & IMMUNOL,POB 28147,SAN ANTONIO,TX 78228, USA. NR 18 TC 9 Z9 9 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0019-2805 J9 IMMUNOLOGY JI Immunology PD AUG PY 1993 VL 79 IS 4 BP 681 EP 684 PG 4 WC Immunology SC Immunology GA LQ746 UT WOS:A1993LQ74600026 PM 8406596 ER PT J AU HUBER, TM AF HUBER, TM TI BOUGAINVILLE - THE FORGOTTEN CAMPAIGN, 1943-1945 - GAILEY,HA SO INTERNATIONAL HISTORY REVIEW LA English DT Book Review RP HUBER, TM (reprint author), US ARMY COMMAND & GEN STAFF COLL,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SIMON FRASER UNIV, INT HISTORY REVIEW PI BURNABY PA EAA 2015, BURNABY BC V5A 1S6, CANADA SN 0707-5332 J9 INT HIST REV JI Int. Hist. Rev. PD AUG PY 1993 VL 15 IS 3 BP 618 EP 619 PG 2 WC History SC History GA LX239 UT WOS:A1993LX23900044 ER PT J AU DAVIS, TME BROWN, AE SMITH, CD AF DAVIS, TME BROWN, AE SMITH, CD TI METABOLIC DISTURBANCES IN PLASMODIUM-COATNEYI-INFECTED RHESUS-MONKEYS SO INTERNATIONAL JOURNAL FOR PARASITOLOGY LA English DT Article DE MALARIA; PLASMODIUM-COATNEYI; RHESUS MONKEYS; GLUCOSE; LACTATE; CALCIUM; PHOSPHATE; CHOLESTEROL ID ACUTE FALCIPARUM-MALARIA; HUMAN CEREBRAL MALARIA; LACTATE; CALCIUM; ACID AB To investigate metabolic disturbances in an animal model of human malaria, four rhesus monkeys (Macaca mulatta) were infected with Plasmodium coatneyi, a parasite which induces cytoadherence of infected erythrocytes. When moribund or the parasitaemia had plateaued, the monkeys were sacrificed (3 animals) or treated with chloroquine (1 animal). Blood and cerebrospinal fluid (CSF) were sampled at intervals between inoculation and sacrifice or treatment. Arterial and CSF glucose and lactate rose during infection, indicating evolving insulin resistance. The arteriovenous difference in glucose concentration also increased, consistent with increased glucose consumption by parasitised tissues. Arterial plasma lactate rose but a positive arteriovenous concentration difference suggested tissue lactate uptake. The animal with the highest plasma lactate at sacrifice remained hyperglycaemic but also had the highest CSF lactate, the greatest cerebral sequestration and neurological depression, and biochemical and histological evidence of severe hepatic pathology. Serum cholesterol and corrected serum calcium fell consistently during infection; serum phosphate was also reduced in animals without renal impairment. These preliminary results indicate that lactic acidosis is a late complication of severe malaria and, by implication from this and other studies, hypoglycaemia occurs even later; other metabolic changes during P. coatneyi infection in rhesus monkeys also parallel those of severe falciparum malaria in humans. The model could be used in further studies of malaria-associated metabolic dysfunction and its management. C1 ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. RP DAVIS, TME (reprint author), UNIV WESTERN AUSTRALIA,FREMANTLE HOSP,DEPT MED,POB 480,FREMANTLE,WA 6160,AUSTRALIA. RI Davis, Timothy/M-5144-2014 FU Wellcome Trust NR 27 TC 13 Z9 13 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0020-7519 J9 INT J PARASITOL JI Int. J. Parasit. PD AUG PY 1993 VL 23 IS 5 BP 557 EP 563 DI 10.1016/0020-7519(93)90160-Z PG 7 WC Parasitology SC Parasitology GA LY721 UT WOS:A1993LY72100004 PM 8225757 ER PT J AU UNDERWOOD, JH AF UNDERWOOD, JH TI STRESS INTENSITY FACTOR AND LOAD-LINE DISPLACEMENT EXPRESSIONS FOR THE ROUND BAR BEND SPECIMEN SO INTERNATIONAL JOURNAL OF FRACTURE LA English DT Note ID EDGE CRACK RP UNDERWOOD, JH (reprint author), USA,CTR ARMAMENT RES DEV & ENGN,WATERVLIET,NY 12189, USA. NR 11 TC 1 Z9 1 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0376-9429 J9 INT J FRACTURE JI Int. J. Fract. PD AUG 1 PY 1993 VL 62 IS 3 BP R49 EP R55 DI 10.1007/BF00012546 PG 7 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA MG501 UT WOS:A1993MG50100008 ER PT J AU SOURWINE, DA AF SOURWINE, DA TI CAS APPLICABILITY, COVERAGE AND DISCLOSURE SO JOURNAL OF ACCOUNTANCY LA English DT Article RP SOURWINE, DA (reprint author), USA,COLL LOGIST MANAGEMENT,FT LEE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER INST CERTIFIED PUBL ACCOUNTANTS PI JERSEY CITY PA HARBORSIDE FINANCIAL CENTER 201 PLAZA THREE, JERSEY CITY, NJ 07311-3881 SN 0021-8448 J9 J ACCOUNTANCY PD AUG PY 1993 VL 176 IS 2 BP 69 EP & PG 0 WC Business, Finance SC Business & Economics GA MA745 UT WOS:A1993MA74500013 ER PT J AU LEVI, M RUDEN, U BIRX, D LOOMIS, L REDFIELD, R LOVGREN, K AKERBLOM, L SANDSTROM, E WAHREN, B AF LEVI, M RUDEN, U BIRX, D LOOMIS, L REDFIELD, R LOVGREN, K AKERBLOM, L SANDSTROM, E WAHREN, B TI EFFECTS OF ADJUVANTS AND MULTIPLE ANTIGEN PEPTIDES ON HUMORAL AND CELLULAR IMMUNE-RESPONSES TO GP160 OF HIV-1 SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HIV-1; ADJUVANTS; GP160; MAP; V3 REGION ID HUMAN-IMMUNODEFICIENCY-VIRUS; CYTOTOXIC T-CELLS; SYNTHETIC PEPTIDES; ENVELOPE PROTEIN; MONOCLONAL-ANTIBODIES; MEDIATED-IMMUNITY; AMINO-ACIDS; B-CELL; GP120; IMMUNIZATION AB The capacity of five different adjuvants, AlPO4, a muramyldipeptide formulation (MDP.TSL), Freund's adjuvant, immunostimulating complex and its matrix components to elicit humoral and cellular responses in rabbits immunized with the human immunodeficiency virus type 1 (HIV-1) envelope protein rgp160IIIB was compared. The highest antibody titers against gp160 and gp41/gp120 epitopes were seen with rgp160 in MDP.TSL or Freund's adjuvant, whereas the broadest responses were seen in rabbits immunized with rgp160 in matrix or MDP.TSL. The broadest spectrum of high-avidity antibodies was also induced by rgp160 in MDP.TSL. Neutralizing titers against HIV-1IIIB, low titers to HIV-1MN, and the most efficient inhibition of viral cell-to-cell spread was seen with rgp160 in MDP.TSL. The strongest and most persisting cellular responses were induced by rgp160 in AlPO4 or MDP.TSL. Using MDP.TSL as the adjuvant, we also improved the immune response against gp120 epitopes by boosting rgp160-primed rabbits with rgp160, multiple antigenic peptides (MAPs), or unconjugated peptides. The MAPs induced high neutralizing titers and were superior to rgp160 alone in inducing both humoral and cellular reactivity. MAPs are therefore strong candidates for inclusion into future HIV-1 vaccines. C1 WALTER REED ARMY INST RES,ROCKVILLE,MD. NATL VET INST,DEPT VIROL,UPPSALA,SWEDEN. VENHALSAN,SOUTH HOSP,STOCKHOLM,SWEDEN. RP LEVI, M (reprint author), NATL BACTERIOL LAB,DEPT VIROL,S-10521 STOCKHOLM,SWEDEN. NR 33 TC 23 Z9 25 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD AUG PY 1993 VL 6 IS 8 BP 855 EP 864 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA LM633 UT WOS:A1993LM63300001 PM 8315572 ER PT J AU WHANGPENG, J CHEN, YMA KNUTSEN, T ZHAO, WP TSAI, S AF WHANGPENG, J CHEN, YMA KNUTSEN, T ZHAO, WP TSAI, S TI CHROMOSOME-STUDIES IN HTLV-I, HTLV-II, AND HIV-1, HIV-2 CELL-LINES INFECTED IN-VIVO AND IN-VITRO SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HTLV-I HTLV-II; HIV-1; HIV-2; CHROMOSOMAL ABNORMALITIES; CYTOGENETIC ANALYSIS ID LEUKEMIA LYMPHOMA VIRUS; PNEUMOCYSTIS-CARINII PNEUMONIA; LYMPHOCYTES; AIDS; RETROVIRUSES AB HTLV-I, II and HIV-1, 2 are T-cell tropic viruses, all belonging to the retrovirus family. These viruses are transmitted horizontally by intimate contact or through blood products. The study of chromosomal changes in these T cells may enhance our understanding of the nature and mechanism of these viral infections. However, because of the cytopathic effect of these viruses on T cells, the direct observation of abnormalities in these cells is sometimes difficult. We performed chromosomal analysis on six HTLV-I cell lines from patients with HTLV-I-positive leukemia/lymphoma, one HTLV-I variant cell line, and two HTLV-II-positive cell lines. The results of these studies were compared with the findings in an earlier (published) study of direct preparations and short-term cultures of cells from 11 HTLV-I-positive NIH patients. Our study also included cytogenetic analysis of seven established cell lines and six normal peripheral bloods infected in vitro with the HTLV-III(B) strain of HIV-1 (five cell lines and six bloods) or HIV-2 (two lines); all were studied both before and after viral infection. The results showed that all six HTLV-1 cell lines and the variant cell line had multiple chromosomal changes: three lines had deletions of chromosome 6, with breakpoints between q21 and q25. Nine of the 11 NIH patients with HTLV-1 had clonal abnormalities, and six of these nine had chromosome 6 deletions with breakpoints ranging from band q11 to band q23. The high incidence of 6q involvement may be of considerable significance in this clinical subgroup of HTLV-1 patients. The two HTLV-II cell lines were established from patients suffering from HTLV-II infection. Both of these cell lines had translocations of chromosome 21 at p11, and both had extra copies of chromosome 20; no known oncogenes or receptors are located on these two chromosomes. Chromosome 17 was the chromosome most frequently involved (three lines) in the five HIV-1-infected cell lines, followed by chromosomes 3 and 21; it is of interest that NGL (also known as C-ERBB2 or NEU oncogene), CD7 (a lymphocyte antigen), HTLV-1 receptor, NGFR (nerve growth factor receptor), and MIC6 are all cell surface antigens coded by genes on chromosome 17q. No specific chromosome abnormalities were found in the normal blood samples infected with HIV-1, and no unique chromosome changes were noted in the two cell lines infected with HIV-2; however, the infected H9 line had a chromosome 17 abnormality, a translocation involving band 17p11. C1 NCI,MED BRANCH,BETHESDA,MD 20892. ACAD SINICA,TAIPEI 115,TAIWAN. WALTER REED ARMY MED CTR,ARMED FORCES INST PATHOL,WASHINGTON,DC 20307. NR 32 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD AUG PY 1993 VL 6 IS 8 BP 930 EP 940 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA LM633 UT WOS:A1993LM63300011 PM 8315577 ER PT J AU HUANG, XR MCCALLUM, DS DAWSON, MD SMIRL, AL BOGGESS, TF HASENBERG, TC TOBER, RL AF HUANG, XR MCCALLUM, DS DAWSON, MD SMIRL, AL BOGGESS, TF HASENBERG, TC TOBER, RL TI AMBIPOLAR DIFFUSION AND CARRIER LIFETIME MEASUREMENTS IN ALL-BINARY (INAS)2(GAAS)5 STRAINED QUANTUM-WELLS GROWN ON GAAS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID CRITICAL LAYER THICKNESS; FIELD-EFFECT TRANSISTORS; MOLECULAR-BEAM EPITAXY; HIGH-TRANSCONDUCTANCE; P-CHANNEL; SUPERLATTICES; INAS/GAAS; DEPENDENCE AB The in-well ambipolar diffusion coefficients and carrier lifetimes in ordered all-binary quantum wells, composed of (InAs)2(GaAs)5 short-period strained-layer superlattices (SPSLSs) grown on [001]-oriented GaAs substrates, are measured using picosecond optically induced transient grating and pump-probe techniques. Quantum wells containing SPSLSs may be expected to exhibit higher in-plane hole mobilities compared to InGaAs ternary alloy quantum wells because of a larger average indium content and reduced disorder scattering in the SPSLS structures. The results obtained in the SPSLSs are compared to those obtained in InGaAs alloy quantum wells of comparable well width and confinement energies. This indicates that, for a given SPSLS and its equivalent alloy, the ambipolar diffusion coefficients are comparable while the carrier lifetimes in the SPSLSs are longer. The longer carrier lifetimes in the SPSLSs suggest that these binary structures possess fewer nonradiative recombination centers than the alloys. The absence of a dramatic improvement in the transport properties, however, may indicate that imperfect interfaces in the SPSLSs may be offsetting their possible advantages, in spite of the fact that optical measurements in the SPSLSs indicate high quality and x-ray and transmission electron microscopic measurements demonstrate the binary nature of these structures. C1 UNIV IOWA,DEPT PHYS & ASTRON,IOWA CITY,IA 52242. HUGHES RES LABS,MALIBU,CA 90265. USA,RES LABS,ELECTR & POWER SOURCES DIRECTORATE,ADELPHI,MD 20783. RP HUANG, XR (reprint author), UNIV IOWA,CTR LASER SCI & ENGN,IOWA CITY,IA 52242, USA. NR 26 TC 3 Z9 3 U1 1 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 1993 VL 74 IS 3 BP 1868 EP 1873 DI 10.1063/1.355301 PG 6 WC Physics, Applied SC Physics GA LQ127 UT WOS:A1993LQ12700061 ER PT J AU KRAEMER, WJ FLECK, SJ DZIADOS, JE HARMAN, EA MARCHITELLI, LJ GORDON, SE MELLO, R FRYKMAN, PN KOZIRIS, LP TRIPLETT, NT AF KRAEMER, WJ FLECK, SJ DZIADOS, JE HARMAN, EA MARCHITELLI, LJ GORDON, SE MELLO, R FRYKMAN, PN KOZIRIS, LP TRIPLETT, NT TI CHANGES IN HORMONAL CONCENTRATIONS AFTER DIFFERENT HEAVY-RESISTANCE EXERCISE PROTOCOLS IN WOMEN SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE LACTATE; ANAEROBIC; STRENGTH TRAINING; AMMONIA; GROWTH FACTORS; GROWTH HORMONE; CORTISOL; TESTOSTERONE ID GROWTH-FACTOR RESPONSES; SERUM TESTOSTERONE; SKELETAL-MUSCLE; STRENGTH; MEN; ADAPTATIONS; PROTEIN; FEMALES; PLASMA AB Nine eumenorrheic women (age 24.11 +/- 4.28 yr) performed each of six randomly assigned heavy-resistance protocols (HREPs) on separate days during the early follicular phase of the menstrual cycle. The HREPs consisted of two series [series 1 (strength, S) and series 2 (hypertrophy, H)] of three protocols, each using identically ordered exercises controlled for load [5 vs. 10 repetitions maximum (RM)], rest period length (1 vs. 3 min), and total work (J) within each three-protocol series. Blood measures were determined pre-, mid- (after 4 of 8 exercises), and postexercise (0, 5, 15, 30, 60, 90, 120 min and 24 and 48 h). In series 1, a significant (P < 0.05) reduction in growth hormone (GH) was observed at 90 min postexercise for all three protocols. In series 2, the 10-RM protocol with 1-min rest periods (H10/1) produced significant increases above rest in GH concentrations at 0, 5, and 15 min postexercise, and the H10/1 and H5/1 protocols demonstrated significant reductions at 90 and 120 min postexercise. Cortisol demonstrated significant increases in response to the S10/3 protocol at 0 min, to the H10/1 protocol at midexercise and at 0 and 5 min postexercise, and to the H5/1 protocol at 5 and 15 min postexercise. No significant changes were observed in total insulin-like growth factor I, total testosterone, urea, or creatinine for any of the HREPs. Significant elevations in whole blood lactate and ammonia along with significant reductions in blood glucose were observed. Hormonal and metabolic blood variables measured in the early follicular phase of the menstrual cycle varied in response to different HREPs. The most dramatic increases above resting concentrations were observed with the H10/1 protocol, indicating that the more glycolytic HREPs may stimulate greater GH and cortisol increases. C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. US OLYMP COMM,DIV SPORTS SCI & TECHNOL,COLORADO SPRINGS,CO 80909. RP KRAEMER, WJ (reprint author), PENN STATE UNIV,CTR SPORTS MED,117 ANN BLDG,UNIV PK,PA 16802, USA. NR 45 TC 168 Z9 176 U1 0 U2 12 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD AUG PY 1993 VL 75 IS 2 BP 594 EP 604 PG 11 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA LT582 UT WOS:A1993LT58200017 PM 8226457 ER PT J AU OBERHELMAN, RA KOPECKO, DJ VENKATESAN, MM SALAZARLINDO, E GOTUZZO, E YI, A CHEAWOO, E RUIZ, R FERNANDEZPRADA, C LEONBARUA, R SACK, RB AF OBERHELMAN, RA KOPECKO, DJ VENKATESAN, MM SALAZARLINDO, E GOTUZZO, E YI, A CHEAWOO, E RUIZ, R FERNANDEZPRADA, C LEONBARUA, R SACK, RB TI EVALUATION OF ALKALINE PHOSPHATASE-LABELED IPAH PROBE FOR DIAGNOSIS OF SHIGELLA INFECTIONS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID ENTEROINVASIVE ESCHERICHIA-COLI; FLEXNERI; CHILDHOOD; THAILAND; GENE AB The presence of many enteropathogens which are not easily detectable by routine stool culture has led to the development of alternative diagnostic methods. One of these techniques, nucleic acid probe hybridization, has been used to identify Shigella spp. and enteroinvasive Escherichia coli (EIEC) in stool specimens through the detection of genetic material encoded by a specific large almost-equal-to 200-kbp virulence-related plasmid. In the present study, an alkaline phosphatase-labelled oligonucleotide probe developed to detect the gene for ipaH, a repetitive genetic sequence thought to be present on both the virulence-related plasmid and the chromosomes of all strains of Shigella and EIEC, was tested in a developing-country setting through a prospective clinical trial. In a group of 219 Peruvian adults and children with acute gastroenteritis, the ipaH probe detected 85% of cases of shigellosis and demonstrated a specificity of 95% when compared with simultaneous detection by several stool culture techniques. Additionally, three cases of EIEC infection which could not be diagnosed by culture methods alone were detected with the ipaH probe and were confirmed by plasmid analysis and Sereny testing. These preliminary results suggest that, with further research, the ipaH probe should prove to be a useful and rapid adjunct in the diagnosis of acute gastroenteritis in developing countries. C1 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT INT HLTH,DIV GEOG MED,BALTIMORE,MD 21205. WALTER REED ARMY INST RES,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307. UNIV PERUANA CAYETANO HEREDIA,LIMA 100,PERU. NR 11 TC 14 Z9 14 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD AUG PY 1993 VL 31 IS 8 BP 2101 EP 2104 PG 4 WC Microbiology SC Microbiology GA LM795 UT WOS:A1993LM79500026 PM 8370736 ER PT J AU GRUNBERG, SM CROWLEY, J LIVINGSTON, R GILL, I WILLIAMSON, SK OROURKE, T BRAUN, T MARSHALL, ME WEICK, JK BALCERZAK, SP MARTINO, RL AF GRUNBERG, SM CROWLEY, J LIVINGSTON, R GILL, I WILLIAMSON, SK OROURKE, T BRAUN, T MARSHALL, ME WEICK, JK BALCERZAK, SP MARTINO, RL TI EXTENDED ADMINISTRATION OF ORAL ETOPOSIDE AND ORAL CYCLOPHOSPHAMIDE FOR THE TREATMENT OF ADVANCED NON-SMALL-CELL LUNG-CANCER - A SOUTHWEST-ONCOLOGY-GROUP STUDY SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID PHASE-II TRIAL; COMBINATION CHEMOTHERAPY; PHARMACOLOGY C1 UNIV SO CALIF,SCH MED,LOS ANGELES,CA 90033. OHIO STATE UNIV,CTR HLTH,COLUMBUS,OH 43210. UNIV SO ALABAMA,MOBILE,AL 36688. SW ONCOL GRP,CTR STAT,SEATTLE,WA. PUGET SOUND ONCOL CONSORTIUM,SEATTLE,WA. UNIV KANSAS,MED CTR,KANSAS CITY,KS 66103. BROOKE ARMY MED CTR,SAN ANTONIO,TX. WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236. UNIV COLORADO,BOULDER,CO 80309. UNIV CINCINNATI,MED CTR,CINCINNATI,OH 45267. CLEVELAND CLIN EDUC FDN,CLEVELAND,OH 44106. FU NCI NIH HHS [CA-12644, CA-20319, CA-37429] NR 15 TC 14 Z9 14 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD AUG PY 1993 VL 11 IS 8 BP 1598 EP 1601 PG 4 WC Oncology SC Oncology GA LR480 UT WOS:A1993LR48000024 PM 8393099 ER PT J AU JENSEN, JO CARRIERI, AH VLAHACOS, CP ZEROKA, D HAMEKA, HF MERROW, CN AF JENSEN, JO CARRIERI, AH VLAHACOS, CP ZEROKA, D HAMEKA, HF MERROW, CN TI EVALUATION OF ONE-ELECTRON INTEGRALS FOR ARBITRARY OPERATORS V(R) OVER CARTESIAN GAUSSIANS - APPLICATION TO INVERSE-SQUARE DISTANCE AND YUKAWA OPERATORS SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article ID SCREENED COULOMB POTENTIALS; MOLECULAR INTEGRALS; REDUCED FORM AB A general procedure is presented for generating one-electron integrals over any arbitrary potential operator that is a function of radial distance only. The procedure outlines that for a nucleus centered at point C integrals over Cartesian Gaussians can be written as linear combinations of I-D integrals. These Cartesian Gaussian functions are expressed in a compact form involving easily computed auxiliary functions. It is well known that integrals over the Coulomb operator can be expressed in terms of F(n)(T) integrals, where [GRAPHICS] By means of a substitution for F(n)(T) by other simple functions, algorithms that form integrals over an arbitrary function can be generated. Formation of such integrals is accomplished with minor editing of existing code based on the McMurchie-Davidson formalism. Further, the method is applied using the inverse-square distance and Yukawa potential operators V(r) over Cartesian Gaussian functions. Thus, the proposed methodology covers a large class of one-electron integrals necessary for theoretical studies of molecular systems by ab initio calculations. Finally, by virtue of the procedure's recursive nature it provides us with an efficient scheme of computing the proposed class of one-electron integrals. (C) 1993 by John Wiley & Sons, Inc. C1 SCI & TECHNOL CORP,HAMPTON,VA 23666. LEHIGH UNIV,DEPT CHEM,BETHLEHEM,PA 18015. UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104. RP JENSEN, JO (reprint author), USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 23 TC 5 Z9 5 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0192-8651 J9 J COMPUT CHEM JI J. Comput. Chem. PD AUG PY 1993 VL 14 IS 8 BP 986 EP 994 DI 10.1002/jcc.540140814 PG 9 WC Chemistry, Multidisciplinary SC Chemistry GA LM546 UT WOS:A1993LM54600013 ER PT J AU BRACUTI, AJ AF BRACUTI, AJ TI CRYSTAL AND MOLECULAR-STRUCTURE OF TRIETHANOLAMMONIUM NITRATE (TEAN) SO JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH LA English DT Article AB The crystal and molecular structure of crystalline triethanolammonium nitrate (TEAN) was determined. TEAN is monoclinic with space group P2(1)/c and has lattice parameters a = 6.592(1), b = 16.358(1), c = 9.3850(8) angstrom and beta = 90.87(1)-degrees. Based on four formula weights of TEAN per unit cell, the computed density is 1.393 g/cm 3. The structure is a three-dimensional hydrogen bonded network of cations and anions. An interesting feature of the cation conformation is the presence of intramolecular trifurcated hydrogen bonding of the proton. RP BRACUTI, AJ (reprint author), USA,ARDEC,PICATINNY ARSENAL,NJ 07869, USA. NR 5 TC 12 Z9 12 U1 0 U2 2 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0277-8068 J9 J CRYST SPECTROSC PD AUG PY 1993 VL 23 IS 8 BP 669 EP 673 DI 10.1007/BF01325192 PG 5 WC Crystallography; Spectroscopy SC Crystallography; Spectroscopy GA LP626 UT WOS:A1993LP62600010 ER PT J AU VYDYANATH, HR ELLSWORTH, JA FISHER, RF KENNEDY, JJ JOHNSON, CJ NEUGEBAUER, GT AF VYDYANATH, HR ELLSWORTH, JA FISHER, RF KENNEDY, JJ JOHNSON, CJ NEUGEBAUER, GT TI VAPOR-PHASE EQUILIBRIA IN THE CD1-XZNXTE ALLOY SYSTEM SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE CDZNTE ALLOYS; TE ANNEALING IN CD AND ZN VAPOR; VAPOR-PHASE EQUILIBRIA ID CDTE SOLID-SOLUTIONS; MOLE PERCENT CDTE; PARTIAL PRESSURES; GROWTH AB Cd1-xZnxTe compounds of different compositions have been prepared at temperatures ranging from 400 to 1000-degrees-C by annealing elemental Te in sealed quartz ampoules, in an atmosphere comprising vapors of Cd and Zn whose partial pressures were varied by varying the composition of the binary Cd1-yZny alloys which provided the Cd and Zn vapors in these annealing experiments. The chemical compositions of the resulting Cd1-xZnxTe compounds have been analyzed using electron probe microanalytical techniques. Results indicate that presence of a 0.5% Zn along with Cd in a closed or semi-closed system may prove to be beneficial in preventing decomposition and/or formation of a metal/non metal phase during annealing of Cd0.96Zn0.04Te substrates. Using the thermodynamic data in the literature for the binary Cd1-yZny alloys and with the assumption that the activities of the Cd and Zn components are weakly dependent on temperature, the partial pressures of Cd and Zn in equilibrium with the Cd1-xZnxTe compounds at various temperatures have been evaluated. C1 USA,CECOM,NIGHT VIS & ELECTROOPT DIRECTORATE,FT BELVOIR,VA 22060. II VI INC,SAXONBURG,PA 16056. RP VYDYANATH, HR (reprint author), AEROJET ELECTR,DIV SYST,1100 W HOLLYVALE ST,AZUSA,CA 91702, USA. NR 9 TC 28 Z9 34 U1 1 U2 1 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 1993 VL 22 IS 8 BP 1067 EP 1071 DI 10.1007/BF02817526 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA LR505 UT WOS:A1993LR50500039 ER PT J AU VYDYANATH, HR ELLSWORTH, JA PARKINSON, JB KENNEDY, JJ DEAN, B JOHNSON, CJ NEUGEBAUER, GT SEPICH, J LIAO, PK AF VYDYANATH, HR ELLSWORTH, JA PARKINSON, JB KENNEDY, JJ DEAN, B JOHNSON, CJ NEUGEBAUER, GT SEPICH, J LIAO, PK TI THERMOMIGRATION OF TE PRECIPITATES AND IMPROVEMENT OF (CD,ZN)TE SUBSTRATE CHARACTERISTICS FOR THE FABRICATION OF LWIR (HG,CD)TE PHOTODIODES SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE CDZNTE SUBSTRATES; LPE; LWIR HGCDTE DEVICE ARRAYS; THERMOMIGRATION OF TE; LPE AB (Cd,Zn)Te wafers containing Te precipitates have been annealed under well defined thermodynamic conditions at temperatures below and above the melting of Te. Results of the examination of the wafers with infrared microscopy before and after the anneals indicate a substantial reduction of the Te precipitates in wafers annealed at temperatures in excess of the melting point of Te compared with those annealed at temperatures below the melting point of Te. These results confirm the thermomigration of liquid Te precipitates to be the principally operative mechanism during annealing in the elimination of these precipitates in (Cd,Zn)Te wafers. The occurrence of Te precipitates in (Hg,Cd)Te epitaxial layers grown on (Cd,Zn)Te substrates containing Te precipitates is also explained on the basis of thermomigration of these precipitates during LPE growth from the substrates to the epilayers. Absence of occurrence of Te precipitates in (Hg,Cd)Te epilayers grown on annealed (Cd,Zn)Te substrates with negligible Te precipitates is also confirmed. Usefulness of annealing (Cd,Zn)Te substrates-to eliminate Te precipitates -prior to epilayer growth is confirmed via demonstration of improved long wavelength infrared (Hg,Cd)Te device array performance uniformity in epitaxial layers grown on (Cd,Zn)Te substrates with negligible Te precipitates after annealing. C1 USA,CECOM,NIGHT VIS & ELECTROOPT DIRECTORATE,FT BELVOIR,VA 22060. II VI INC,SAXONBURG,PA 16056. TEXAS INSTRUMENTS INC,DALLAS,TX 75265. RP VYDYANATH, HR (reprint author), AEROJET ELECTR,DIV SYST,1100 W HOLLYVALE ST,AZUSA,CA 91702, USA. RI Chang, Yong/B-3541-2009 NR 5 TC 38 Z9 39 U1 1 U2 4 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 1993 VL 22 IS 8 BP 1073 EP 1080 DI 10.1007/BF02817527 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA LR505 UT WOS:A1993LR50500040 ER PT J AU JOYCE, AP DONNELLY, JC AF JOYCE, AP DONNELLY, JC TI EVALUATION OF THE EFFECTIVENESS AND COMFORT OF INCISIVE NERVE ANESTHESIA GIVEN INSIDE OR OUTSIDE THE MENTAL FORAMEN SO JOURNAL OF ENDODONTICS LA English DT Article AB Thirty volunteer subjects were given bilateral injections of one-half carpule of 2% Xylocaine with 1:100,000 epinephrine to anesthetize the incisive nerve. Injections were given either inside or outside the mental foramen. Success (80/80 reading) and duration of anesthesia were verified with the Analytic Technology pulp tester. Pain and preference for either injection type were evaluated via questionnaire. The mental foramen could be located in 1 min 56.6% of the time. There was a significantly greater chance of success for injections given inside the foramen for the second bicuspid (p = 0.0422) and the canine (p = 0.015). There was no statistically significant difference in success for either type injection for the first bicuspid (p = 0.184). There was no significant difference in duration of anesthesia whether given inside or outside the foramen and no difference in pain of injection with either type. Patients had no clear-cut preference for either injection type. C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. NR 6 TC 10 Z9 10 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD AUG PY 1993 VL 19 IS 8 BP 409 EP 411 DI 10.1016/S0099-2399(06)81506-2 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LQ521 UT WOS:A1993LQ52100007 PM 8263444 ER PT J AU JURCAK, JJ BELLIZZI, R LOUSHINE, RJ AF JURCAK, JJ BELLIZZI, R LOUSHINE, RJ TI SUCCESSFUL SINGLE-VISIT ENDODONTICS DURING OPERATION DESERT SHIELD SO JOURNAL OF ENDODONTICS LA English DT Article AB This article reports on the incidence of success following single-visit endodontic therapy. Non-surgical endodontic therapy was performed on 210 teeth in 167 patients who were rapidly deployed during the initial stages of Operation Desert Shield. Upon their return, 97 patients were recalled for follow-up evaluation. This study evaluated 102 teeth. The recall rate was 58% with a success rate of 89%. C1 ENDODONT RESIDENCY PROGRAM,FT GORDON,GA. RP JURCAK, JJ (reprint author), USA,DENTAL ACTIV,FT BENNING,GA 31905, USA. NR 16 TC 13 Z9 16 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD AUG PY 1993 VL 19 IS 8 BP 412 EP 413 DI 10.1016/S0099-2399(06)81507-4 PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LQ521 UT WOS:A1993LQ52100008 PM 8263445 ER PT J AU MUNAVALLI, S LEWIS, EO MULLER, AJ ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP AF MUNAVALLI, S LEWIS, EO MULLER, AJ ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP TI NOVEL REACTIONS OF PERFLUORO-2-(TRIFLUOROMETHYL)-PROPENE SO JOURNAL OF FLUORINE CHEMISTRY LA English DT Article AB Unlike its hydrocarbon counterpart, perfluoro-2-(trifluoromethyl)propene is a highly reactive compound. It participates in both heterolytic and homolytic reactions. It readily reacts with nucleophiles and sluggishly with electrophiles. It reacts as well with common organic solvents, such as dimethylformamide, ethanol and others. In this communication, we describe its reactions with trifluoromethylthiocopper, sulfur trioxide and tributyltin cyanide, the mechanism of formation of the various products and their mass spectral data. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP MUNAVALLI, S (reprint author), GEOCENTERS INC,FT WASHINGTON,MD 20774, USA. NR 31 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-1139 J9 J FLUORINE CHEM JI J. Fluor. Chem. PD AUG PY 1993 VL 63 IS 3 BP 253 EP 264 DI 10.1016/S0022-1139(00)80569-2 PG 12 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA LP188 UT WOS:A1993LP18800008 ER PT J AU SIKES, A WHITFIELD, S ROSANO, DJ AF SIKES, A WHITFIELD, S ROSANO, DJ TI RECOVERY OF HEAT-STRESSED SPORES OF BACILLUS-STEAROTHERMOPHILUS ON SOLID MEDIA CONTAINING CALCIUM-DEFICIENT AND MAGNESIUM-DEFICIENT AGAR SO JOURNAL OF FOOD PROTECTION LA English DT Note ID RESISTANCE AB Recovery of heat-stressed (121.1-degrees-C) spores of Bacillus stearothermophilus (ATCC 12980) produced on solid sporulation agar media (Cook and Brown) and recovered on antibiotic assay medium + 0.1% soluble starch agar media appeared to be dependent on the concentration of two trace metals, calcium (Ca) and magnesium (Mg), in the agar component of the nutrient growth medium. Results from the present investigation indicated that heat-stressed (121.1-degrees-C, 0-20 min) spores of B. stearothermophilus were not recovered on agar media containing commercial agar products from BBL, Bitek (Difco), and Oxoid; however, under similar experimental conditions, heat-stressed spores were recovered on solid agar media containing Bacto (Difco) or Acumedia agar products. Chemical analysis of the trace minerals content of all five agar products indicated that the Ca content (% dry weight) of BBL, Bitek, and Oxoid products was less-than-or-equal-to 0.01% of the dry weight; the Ca content of Bacto and Acumedia agars was 15- to 20-fold greater. Similarly, the Mg content varied considerably between agars. Bacto and Acumedia agar products contained 0.073 and 0.043% Mg, respectively; the Mg content of BBL, Bitek, and Oxoid products was 0.003, 0.006, and 0.0007%, respectively. The recovery potential of mineral-deficient agar media (Ca and Mg less-than-or-equal-to 0.01% of dry weight) was restored by increasing the Ca and Mg levels to those found in mineral sufficient agar media (greater-than-or-equal-to 0.2 and 0.06% Ca and Mg, respectively). RP SIKES, A (reprint author), USA,NATICK RES & DEV LABS,NATICK,MA 01760, USA. NR 14 TC 8 Z9 8 U1 0 U2 1 PU INT ASSOC MILK FOOD ENVIRONMENTAL SANITARIANS, INC PI DES MOINES PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2838 SN 0362-028X J9 J FOOD PROTECT JI J. Food Prot. PD AUG PY 1993 VL 56 IS 8 BP 706 EP 709 PG 4 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA LU067 UT WOS:A1993LU06700011 ER PT J AU KRAKAUER, T PETERS, CJ AF KRAKAUER, T PETERS, CJ TI LIPOPOLYSACCHARIDE INHIBITS THE PRODUCTION OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN A HUMAN MONOCYTIC CELL-LINE SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID INVITRO INFECTION; INTERFERONS; IMMUNOSUPPRESSION; INTERLEUKIN-6; REPLICATION; MACROPHAGE; BLOOD; ALPHA AB The human monocytic cell line THP-1 was used as a model to study the mechanism of infection in the monocyte/macrophage, a natural target of lymphocytic choriomeningitis virus (LCMV) infection in vivo. Both the virulent strain, LCMV. WE, and the avirulent strain, LCMV. ARM, infected THP-1 cells, but did not stimulate THP-1 cells to secrete interleukin 1 (IL-1) or tumour necrosis factor (TNF-alpha). When lipopolysaccharide (LPS) was added to THP-1 cells together with LCMV, an 80 to 90 % reduction in the number of infected cells (measured by immunofluorescence) and a 90% reduction in viral plaques was observed 5 to 6 days postinfection. Neither interferon alpha (IFN-alpha) nor IFN-beta were detected in supernatants from THP-1 cells after the addition of LCMV, LPS. or LPS plus LCMV. In contrast. the same levels of IL-1 and TNF-alpha were observed in the presence of LPS and LCMV, or LPS alone. However, antibodies to IL-1, TNF-alpha, interleukin 6 and IFN-alpha did not block the antiviral effect of LPS. In kinetic studies, LPS added 1 day after adding LCMV to THP-1 cells was still effective in reducing the number of infected cells. Our findings suggest that LPS alters cellular metabolism, possibly through the induction of IFN-alpha, and that IFN-alpha in the absence of LPS suppresses virus production. RP KRAKAUER, T (reprint author), USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21702, USA. NR 25 TC 3 Z9 3 U1 0 U2 0 PU SOC GENERAL MICROBIOLOGY PI READING PA HARVEST HOUSE 62 LONDON ROAD, READING, BERKS, ENGLAND RG1 5AS SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD AUG PY 1993 VL 74 BP 1653 EP 1656 DI 10.1099/0022-1317-74-8-1653 PN 8 PG 4 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA LQ264 UT WOS:A1993LQ26400023 PM 8345356 ER PT J AU XIAO, SY LIANG, MF SCHMALJOHN, CS AF XIAO, SY LIANG, MF SCHMALJOHN, CS TI MOLECULAR AND ANTIGENIC CHARACTERIZATION OF HV114, A HANTAVIRUS ISOLATED FROM A PATIENT WITH HEMORRHAGIC-FEVER WITH RENAL SYNDROME IN CHINA SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID POLYMERASE CHAIN-REACTION; HEMORRHAGIC-FEVER; MESSENGER-RNA; VIRUS; NUCLEOTIDE; SEQUENCE; SEGMENTS; TRIAL AB The relationship of a Hantaan-like virus (HV114), isolated from a patient with haemorrhagic fever with renal syndrome in Hubei Province, People's Republic of China, to other pathogenic hantaviruses was evaluated by cross-neutralization studies and nucleotide sequence analysis of the M genome segment. Plaque reduction neutralization assays indicated that HV114 is closely related to prototype Hantaan (HTN) virus, strain 76118, which was originally isolated from an Apodemus field mouse in Korea. Comparison of the M genome segments of HTN 76-118 and HV114 revealed sequence identity of 84.7% and 95-4% for nucleotides and deduced amino acids. respectively. These data demonstrate that HV114 and 76-118 are two closely related but different isolates of HTN virus, establishing the scientific basis for testing and future use in China of a recombinant vaccine expressing the genome of HTN virus strain 76-118. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. RI Xiao, Shu-Yuan/E-2215-2012 NR 17 TC 33 Z9 45 U1 0 U2 0 PU SOC GENERAL MICROBIOLOGY PI READING PA HARVEST HOUSE 62 LONDON ROAD, READING, BERKS, ENGLAND RG1 5AS SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD AUG PY 1993 VL 74 BP 1657 EP 1659 DI 10.1099/0022-1317-74-8-1657 PN 8 PG 3 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA LQ264 UT WOS:A1993LQ26400024 PM 8102176 ER PT J AU DALY, SF AF DALY, SF TI WAVE-PROPAGATION IN ICE-COVERED CHANNELS SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article ID RIVER AB The propagation of waves in ice-covered channels is analyzed using linearized forms of the three equations governing one-dimensional unsteady flow in rectangular ice-covered channels. The equations describe fluid continuity. momentum, and the ice-cover response. The ice cover is assumed to be a relatively thin, continuous elastic plate. Five well-defined bands of wave celerity are found in the wave-number spectrum. Three bands exist at wavelengths longer than about 20 characteristic lengths of the ice and define the range of quasi-open-channel wave propagation over which the wave celerities are analogous to open-channel wave celerities. Two bands exist at shorter wavelengths: an ice-coupled band (in which the wave celerity increases sharply with wave number and is a function of the wavelength and the ice-cover properties) and, at even shorter wavelengths. an acoustic band. The attenuation of ice-coupled and acoustic waves is found to be small. The group velocity over the dispersive ice-coupled band is found to always exceed the wave celerities. RP DALY, SF (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 17 TC 14 Z9 15 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD AUG PY 1993 VL 119 IS 8 BP 895 EP 910 DI 10.1061/(ASCE)0733-9429(1993)119:8(895) PG 16 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA LN326 UT WOS:A1993LN32600002 ER PT J AU TSAREV, SA TSAREVA, TS EMERSON, SU KAPIKIAN, AZ TICEHURST, J LONDON, W PURCELL, RH AF TSAREV, SA TSAREVA, TS EMERSON, SU KAPIKIAN, AZ TICEHURST, J LONDON, W PURCELL, RH TI ELISA FOR ANTIBODY TO HEPATITIS-E VIRUS (HEV) BASED ON COMPLETE OPEN-READING FRAME-2 PROTEIN EXPRESSED IN INSECT CELLS - IDENTIFICATION OF HEV INFECTION IN PRIMATES SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID NON-B HEPATITIS; TRANSMITTED NON-A; LINKED-IMMUNOSORBENT-ASSAY; MONOCLONAL-ANTIBODIES; FELINE CALICIVIRUS; C VIRUS; GENE; CHIMPANZEES; SEQUENCE; EPIDEMIC AB A recombinant baculovirus containing the complete open-reading frame (ORF)-2 region of the hepatitis E virus (HEV) genome was constructed. The major protein synthesized in insect cells infected with recombinant virus was about the size expected for the complete ORF-2 product. This protein reacted in a Western blot assay with plasma from an HEV-infected chimpanzee. Lysates of the recombinant virus-infected insect cells were used in ELISA to monitor seroconversion of eight primate species (chimpanzees, four species of Old World monkeys, and three species of New World monkeys) inoculated with HEV. Homologous detector anti-immunoglobulin was more sensitive than heterologous anti-immunoglobulin for detecting anti-HEV by ELISA. All primate species except tamarins seroconverted after inoculation with HEV, although anti-HEV titers of Old World monkey species were generally higher than those of New World monkey species. The ELISA with complete ORF-2 antigen appeared to be a sensitive and practical method for detecting anti-HEV. C1 NIAID,EPIDEMIOL SECT,INFECT DIS LAB,BETHESDA,MD 20892. GEORGETOWN UNIV,DIV MOLEC VIROL & IMMUNOL,ROCKVILLE,MD. WALTER REED ARMY INST RES,DEPT VIRAL DIS,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP TSAREV, SA (reprint author), NIAID,HEPATITUS VIRUSES SECT,INFECT DIS LAB,BLDG 7,RM 200,BETHESDA,MD 20892, USA. RI Ticehurst, John/I-7532-2012 FU NIAID NIH HHS [AI-05069] NR 33 TC 171 Z9 185 U1 1 U2 5 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG PY 1993 VL 168 IS 2 BP 369 EP 378 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA LN813 UT WOS:A1993LN81300017 PM 8335973 ER PT J AU PETRI, WA HAQUE, R KRESS, K WOOD, S WILKINS, T JACKSON, TFHG LYERLY, D AF PETRI, WA HAQUE, R KRESS, K WOOD, S WILKINS, T JACKSON, TFHG LYERLY, D TI PREDICTIVE VALUE OF DIAGNOSTIC-TESTS AND PREVALENCE OF INVASIVE ENTAMOEBA-HISTOLYTICA INFECTION - REPLY SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter ID DIFFERENTIATION; ZYMODEMES C1 INT CTR DIARRHOEAL DIS RES,DHAKA,BANGLADESH. USA,CHEM RES DEV COMMAND,ABERDEEN PROVING GROUND,MD 21010. TECHLAB,BLACKSBURG,VA. RES INST DIS TROP ENVIRONM,CONGELLA,SOUTH AFRICA. RP PETRI, WA (reprint author), UNIV VIRGINIA,HLTH SCI CTR,RM 2115 MR4 BLDG,CHARLOTTESVILLE,VA 22908, USA. NR 8 TC 2 Z9 2 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG PY 1993 VL 168 IS 2 BP 514 EP 515 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA LN813 UT WOS:A1993LN81300047 ER PT J AU FINE, JD JOHNSON, LB CRONCE, D WRIGHT, JT LEIGH, IM MCCOLLOUGH, M BRIGGAMAN, RA AF FINE, JD JOHNSON, LB CRONCE, D WRIGHT, JT LEIGH, IM MCCOLLOUGH, M BRIGGAMAN, RA TI INTRACYTOPLASMIC RETENTION OF TYPE-VII COLLAGEN AND DOMINANT DYSTROPHIC EPIDERMOLYSIS-BULLOSA - REVERSAL OF DEFECT FOLLOWING CESSATION OF OR MARKED IMPROVEMENT IN DISEASE-ACTIVITY SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Article DE EPIDERMOLYSIS BULLOSA; GENODERMATOSES; BULLOUS DISEASE; BASEMENT MEMBRANE; EXTRACELLULAR MATRIX; TYPE-VII COLLAGEN; MONOCLONAL ANTIBODIES; TRANSIENT BULLOUS DERMOLYSIS OF THE NEWBORN ID EPIDERMAL BASEMENT-MEMBRANE; MONOCLONAL-ANTIBODY; DERMOLYSIS; EXPRESSION; COMPONENT; JUNCTION; NEWBORN; ANTIGEN AB It has been recently shown that the presence of perinuclear ''stellate bodies'' within the epidermis in patients with a form of dominant dystrophic epidermolysis bullosa named ''transient bullous dermolysis of the newborn'' corresponds to collections of type VII collagen. To determine the temporal relationship of this unique immunohistochemical defect with course of clinical disease activity, we have longitudinally studied the expression of two epitopes of type VII collagen (LH 7: 2; L3d) in nine patients in four such kindreds by immunofluorescence and immunoelectron microscopic technique. In every infant so studied at the time of active blistering, type VII collagen was detectable primarily within basilar and, to a lesser extent, suprabasilar keratinocytes. In contrast, type VII collagen was detectable solely in linear array along the dermoepidermal junction in skin from each patient following complete cessation or at least marked diminution of visible clinical disease activity. These findings support the hypothesis that the temporary mechanical fragility and blistering of the skin in infants with this rare subset of dominant dystrophic epidermolysis bullosa reflect the presence of reduced amounts of type VII collagen along the dermoepidermal function, and that this diminution may be the result of either a delay in transport and integration of type VII collagen from basilar keratinocytes into the skin basement membrane or excessive phagocytosis of type VII collagen. C1 UNIV N CAROLINA,SCH PUBL HLTH,DEPT CURRICULUM PUBL HLTH NURSING,CHAPEL HILL,NC 27514. UNIV N CAROLINA,SCH DENT,DEPT PEDIAT DENT,CHAPEL HILL,NC 27514. SO CLIN CTR,NATL EPIDERMOLYSIS BULLOSA REGISTRY,CHAPEL HILL,NC. BROOKE ARMY MED CTR,DEPT DERMATOL,SAN ANTONIO,TX. LONDON HOSP,DEPT DERMATOL,LONDON E1 1BB,ENGLAND. IMPERIAL CANC RES FUND,SKIN TUMOUR LAB,LONDON WC2A 3PX,ENGLAND. RP FINE, JD (reprint author), UNIV N CAROLINA,N CAROLINA MEM HOSP,SCH MED,DEPT DERMATOL,ROOM 137,CB 7600,CHAPEL HILL,NC 27514, USA. FU NIAMS NIH HHS [NIAMS NO1 AR22200, NIAMS NO1 AR62271, NIAMS NO1 AR22201] NR 16 TC 19 Z9 19 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD AUG PY 1993 VL 101 IS 2 BP 232 EP 236 DI 10.1111/1523-1747.ep12364899 PG 5 WC Dermatology SC Dermatology GA LP487 UT WOS:A1993LP48700024 PM 8345225 ER PT J AU CHAU, KH DAWSON, GJ BILE, KM MAGNIUS, LO SJOGREN, MH MUSHAHWAR, IK AF CHAU, KH DAWSON, GJ BILE, KM MAGNIUS, LO SJOGREN, MH MUSHAHWAR, IK TI DETECTION OF IGA CLASS ANTIBODY TO HEPATITIS-E VIRUS IN SERUM SAMPLES FROM PATIENTS WITH HEPATITIS-E VIRUS-INFECTION SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE HEPATITIS-E VIRUS HEV; HEV INFECTION; ANTI-HEV ANTIBODIES ID UNITED-STATES TRAVELER; NON-B HEPATITIS; ENZYME-IMMUNOASSAY; DELTA-VIRUS; NON-A; ANTIGEN; DEFICIENCY; IDENTIFICATION; PAKISTAN; EPIDEMIC AB A newly developed assay for IgA class antibody to hepatitis E virus (IgA anti-HEV) was used to study 145 serum samples collected during an outbreak of an enterically transmitted hepatitis that occurred in 3 villages in the lower Shebeli region of Southern Somalia between January, 1988 and November, 1989. A total of 52.4% of the afflicted patients were found positive for IgA anti-HEV, and 73.1% of these were also positive for IgM. Both antibodies disappeared during the convalescence period. Similar results were also seen in serum obtained from sporadic cases of acute waterborne hepatitis in Pakistan. (C) 1993 Wiley-Liss, Inc. C1 ABBOTT LABS,EXPTL BIOL RES,N CHICAGO,IL 60064. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. FAC MED MOGADISHU,DEPT MED,MUQDISHO,SOMALIA. NATL BACTERIOL LAB,DEPT VIROL,S-10521 STOCKHOLM,SWEDEN. NR 27 TC 37 Z9 37 U1 1 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD AUG PY 1993 VL 40 IS 4 BP 334 EP 338 DI 10.1002/jmv.1890400414 PG 5 WC Virology SC Virology GA LP677 UT WOS:A1993LP67700013 PM 8228927 ER PT J AU SCHNECK, DL GROSS, PD TABOR, MW AF SCHNECK, DL GROSS, PD TABOR, MW TI ODONTOGENIC MYXOMA - REPORT OF 2 CASES WITH RECONSTRUCTION CONSIDERATIONS SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Note ID MAXILLECTOMY; JAW C1 EISENHOWER ARMY MED CTR,ORAL & MAXILLOFACIAL SURG SERV,FT GORDON,GA 30905. EISENHOWER ARMY MED CTR,ORAL & MAXILLOFACIAL SURG RESIDENCY PROGRAM,FT GORDON,GA. NR 30 TC 10 Z9 11 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD AUG PY 1993 VL 51 IS 8 BP 935 EP 940 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LR896 UT WOS:A1993LR89600025 PM 8336234 ER PT J AU HELLSTEIN, JH FOTOS, PG LAW, SS KOVACEVIC, M CARRIERE, KC AF HELLSTEIN, JH FOTOS, PG LAW, SS KOVACEVIC, M CARRIERE, KC TI DIFFERENTIATION OF SUGAR ASSIMILATION CHARACTERISTICS AND COLONY PHENOTYPES IN PATHOGENIC AND COMMENSAL ORAL CANDIDAL ISOLATES SO JOURNAL OF ORAL PATHOLOGY & MEDICINE LA English DT Article DE CANDIDA-ALBICANS; COMMENSALISM; PATHOGENICITY; PHENOTYPE ID DENTURE WEARERS; ALBICANS; CANDIDIASIS; YEASTS; INFECTIONS; PROTEINASE; CARRIAGE AB A comparison of sugar assimilation patterns has been made using 72 oral candidal isolates recovered from diseased and non-diseased patients. Significant differences were demonstrated between isolates recovered from diseased versus healthy mouths. In addition, significant changes in colony phenotype (switch frequency and morphologic predominance) were found to relate to predictive data generated from carbon source utilization data. These results suggest that biochemical properties and colony phenotypic characteristics may hold promise in predicting the behavior of oral candidal isolates in disease. C1 UNIV IOWA,COLL DENT,DEPT ORAL PATHOL RADIOL & MED,DSB,IOWA CITY,IA 52242. USA,DENT CORP,FT BLISS,TX. UNIV MANITOBA,MANITOBA CTR HLTH POLICY & EVALUAT,WINNIPEG R3T 2N2,MANITOBA,CANADA. UNIV IOWA,DEPT STAT & ACTUARIAL SCI,IOWA CITY,IA 52242. FU NIDCR NIH HHS [DE09381-OIAI] NR 45 TC 3 Z9 3 U1 0 U2 1 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0904-2512 J9 J ORAL PATHOL MED JI J. Oral Pathol. Med. PD AUG PY 1993 VL 22 IS 7 BP 312 EP 319 DI 10.1111/j.1600-0714.1993.tb01080.x PG 8 WC Dentistry, Oral Surgery & Medicine; Pathology SC Dentistry, Oral Surgery & Medicine; Pathology GA LV978 UT WOS:A1993LV97800007 PM 8229869 ER PT J AU RAWLINGS, JS SMITH, FR GARCIA, J AF RAWLINGS, JS SMITH, FR GARCIA, J TI EXPECTED DURATION OF HOSPITAL STAY OF LOW-BIRTH-WEIGHT INFANTS - GRAPHIC DEPICTION IN RELATION TO BIRTH-WEIGHT AND GESTATIONAL-AGE SO JOURNAL OF PEDIATRICS LA English DT Article ID INTENSIVE-CARE; RISK AB Neonatal duration of hospital stay correlated with both birth weight and gestational age in positively skewed, nonlinear relationships. Within increments of birth weight, gestational age had a semiindependent influence on length of stay. Log length of stay correlated with both birth weight and gestational age in linear, normally distributed relationships. A nomogram is provided for predicting individual lengths of stay. C1 TRIPLER ARMY MED CTR, DEPT PEDIAT, NEONATOL SERV, HONOLULU, HI 96859 USA. RP RAWLINGS, JS (reprint author), MADIGAN ARMY MED CTR, DEPT PEDIAT, NEWBORN MED SERV, TACOMA, WA 98433 USA. NR 9 TC 9 Z9 9 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD AUG PY 1993 VL 123 IS 2 BP 307 EP 309 PG 3 WC Pediatrics SC Pediatrics GA LR295 UT WOS:A1993LR29500023 PM 8345432 ER PT J AU SHAHAN, MH CHUANG, AH BRENNAN, WA DIRKSEN, TR VANDYKE, TE MCPHERSON, JC AF SHAHAN, MH CHUANG, AH BRENNAN, WA DIRKSEN, TR VANDYKE, TE MCPHERSON, JC TI THE EFFECT OF CHLORHEXIDINE IRRIGATION ON TENSILE WOUND STRENGTH SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE CHLORHEXIDINE, THERAPEUTIC USE; WOUND HEALING; PERIODONTAL DISEASES SURGERY ID NEUTROPHIL LOCOMOTION; IMPAIRMENT; INVITRO; SURGERY; INVIVO AB CHLORHEXIDINE IN AN ALCOHOL VEHICLE with flavoring agents has been used as a mouthrinse to reduce plaque accumulation in periodontal surgery patients. The purpose of this study was to evaluate the effects of a chlorhexidine-containing mouthrinse on the early tensile wound strength of healing surgical wounds in the rat. Standardized transdermal incisions were made on each lateral abdominal wall of 40 Sprague-Dawley rats. Wounds were irrigated with 10 ml of 0.12% chlorhexidine or 10 ml of normal saline prior to closure. Animals were sacrificed at 48 hours and 96 hours, and the wound area was excised by a standardized protocol. Wound strength was measured using constant speed tensiometry to determine the tensile strength of the healing incision. Results revealed a significantly reduced tensile wound strength at 48 hours for the chlorhexidine-treated group (127 +/- 18.5 gm) compared to the saline irrigation group (150 +/- 32.3 gm) (P <0.001). However, by 96 hours a significantly increased tensile wound strength was demonstrated by the chlorhexidine treated group (202.1 +/- 21.7 gm) compared to the saline irrigation group (183.2 +/- 37.3 gm) (P<0.05). These data suggest that chlorhexidine-containing mouthrinse irrigation of wounds produced a reduced early tensile wound strength, but ultimately resulted in shorter healing time. C1 MED COLL GEORGIA,AUGUSTA,GA 30912. EASTMAN DENT CTR,ROCHESTER,NY 14620. RP SHAHAN, MH (reprint author), USA,PERIODONTAL RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. FU NIDCR NIH HHS [DE 06436] NR 31 TC 5 Z9 6 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD AUG PY 1993 VL 64 IS 8 BP 719 EP 722 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LV691 UT WOS:A1993LV69100007 PM 8410610 ER PT J AU KORTE, WD SHIH, ML AF KORTE, WD SHIH, ML TI DEGRADATION OF 3 RELATED BIS(PYRIDINIUM)ALDOXIMES IN AQUEOUS-SOLUTIONS AT HIGH-CONCENTRATIONS - EXAMPLES OF UNEXPECTEDLY RAPID AMIDE GROUP HYDROLYSIS SO JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Article ID PERFORMANCE LIQUID-CHROMATOGRAPHY; HI-6; DECOMPOSITION; STABILITY; OXIMES; IDENTIFICATION; PYRIDINIUM; SEPARATION; CHLORIDE); EFFICACY AB The principal initial degradation products of two bis(pyridinium)aldoxime organophosphate-inhibited acetylcholinesterase reactivators, 1 (HI-6) and 3 (HS-6), in concentrated nonbuffered aqueous solutions approximating potential therapeutic dosage concentrations were found to be the carboxylic acid derivatives 2 and 4 formed from the hydrolysis of the amide functional group. Compounds 2 and 4 were prepared by heating 1 and 3 in the presence of high concentrations of hydroxylamine hydrochloride and characterized by H-1 and C-13 NMR, IR, and UV analyses. Estimates of the rates of hydrolysis of the amide groups in 1 and 3 and in model compounds 5, 7, and 8 under similar conditions were determined. The unexpectedly rapid hydrolysis of the amide groups in 1 and 3 was attributed to both the hydrogen ion catalysis of the concentrated aqueous solutions of the unusually acidic bis(pyridinium) aldoximes 1 and 3 and general acid catalysis by the aldoxime group. C1 USA,MED INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 31 TC 2 Z9 2 U1 1 U2 4 PU AMER PHARMACEUTICAL ASSN PI WASHINGTON PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037 SN 0022-3549 J9 J PHARM SCI JI J. Pharm. Sci. PD AUG PY 1993 VL 82 IS 8 BP 782 EP 786 DI 10.1002/jps.2600820805 PG 5 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA LP621 UT WOS:A1993LP62100004 PM 8377113 ER PT J AU LEATHERMAN, DL MIDDLEBROOK, JL AF LEATHERMAN, DL MIDDLEBROOK, JL TI EFFECTS OF EMETINE ON THE SPECIFIC ASSOCIATION OF T-2 TOXIN WITH MAMMALIAN-CELLS SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID EUKARYOTIC RIBOSOMES; PROTEIN-SYNTHESIS; BINDING; INHIBITION; TRICHODERMIN AB The effects of emetine on the association of T-2 toxin with Chinese hamster ovary cells were examined. T-2 toxin-cell association at both 4-degrees-C and 37-degrees-C was reduced by up to 90% after preincubation of cells with emetine. Emetine-induced reduction in T-2 toxin-cell association was time-, temperature-, and concentration-dependent. A 4-min preincubation with emetine at physiological temperature was required to develop the maximum inhibitory effect. After brief exposures (less-than-or-equal-to 5 min), emetine's inhibitory effects on toxin-cell association were reversible. However, after longer exposure periods to emetine (60 min), toxin-cell association was irreversibly blocked. The addition of emetine to cells prebound with toxin resulted in dissociation at a rate 2 to 3 times slower than a competitive chase with nonlabeled toxin. Emetine did not compete directly for T-2 toxin binding to its receptor on isolated, purified, run-off ribosomes. However, the binding of toxin to purified ribosomes prepared from cells preincubated with emetine was markedly reduced. Scatchard analysis indicated that emetine's inhibitory effects on T-2 toxin-cell association were mediated through mixed allosteric and competitive types of inhibition at specific, intracellular, T-2 toxin ribosomal binding sites. C1 USA,MED RES INST INFECT DIS,DIV TOXINOL,FREDERICK,MD 21701. NR 18 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD AUG PY 1993 VL 266 IS 2 BP 732 EP 740 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA LT482 UT WOS:A1993LT48200036 PM 8355204 ER PT J AU LEATHERMAN, DL MIDDLEBROOK, JL AF LEATHERMAN, DL MIDDLEBROOK, JL TI EFFECT OF EMETINE ON T-2 TOXIN-INDUCED INHIBITION OF PROTEIN-SYNTHESIS IN MAMMALIAN-CELLS SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID RAT; ASSOCIATION; MYCOTOXINS; TOXICOSIS; RIBOSOMES; BINDING AB Chinese hamster ovary cells were used to examine the effect of emetine upon the toxicity of T-2 toxin and several related trichothecene inhibitors of polypeptide synthesis. Emetine inhibited protein synthesis and T-2 toxin-cell association in a concentration-dependent manner. The dose-response curves for these two effects were nearly identical. Over a narrow concentration range (0.3-3.0 mug/ml), emetine's inhibition of protein synthesis was partially reversible, whereas its inhibition of toxin-cell association was maintained for extended periods. This sustained inhibition of toxin-cell association, resulted in ''desensitized'' cells with reduced sensitivity to the inhibitory effects of T-2 toxin on protein synthesis. Similar results were obtained when emetine-preincubated cells were challenged with diacetoxyscirpenol, verrucarin A and roridin A. In contrast, there were no measurable effects of emetine upon the response of the cells to the less potent trichothecenes, deoxynivalenol, T-2 tetraol and verrucarol. In addition to emetine, several other inhibitors of polypeptide synthesis were examined for their effects on T-2 toxin-cell association and sensitivity to T-2 toxin. Of these, only cycloheximide inhibited toxin-cell association. Unlike emetine, sustained protection against the effects of T-2 toxin was not observed with cycloheximide. C1 USA,MED RES INST INFECT DIS,DIV TOXINOL,FREDERICK,MD 21701. NR 34 TC 7 Z9 7 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD AUG PY 1993 VL 266 IS 2 BP 741 EP 748 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA LT482 UT WOS:A1993LT48200037 PM 8355205 ER PT J AU SALOMON, M AF SALOMON, M TI CONDUCTANCE OF SOLUTIONS OF LITHIUM BIS(TRIFLUOROMETHANESULFONE)IMIDE IN WATER, PROPYLENE CARBONATE, ACETONITRILE AND METHYL FORMATE AT 25-DEGREES-C SO JOURNAL OF SOLUTION CHEMISTRY LA English DT Article DE ELECTROLYTE CONDUCTANCE; IONIC CONDUCTANCE; ION-PAIR FORMATION; TRIPLE ION FORMATION; NON-COULOMBIC INTERACTIONS; LITHIUM SALTS; BIS(TRIFLUOROMETHANESULFONE)IMIDE ANION; WATER; PROPYLENE CARBONATE; ACETONITRILE; METHYL FORMATE ID 1-1 ELECTROLYTES AB Conductance data for lithium bis(trifluoromethanesulfone)imide, LiN(CF3SO2)2, are reported for the solvents water, propylene carbonate, acetonitrile and methyl formate at 25-degrees-C. Limiting molar conductivities LAMBDA0, association constants K(A), and triple ion formation constants K(t) are reported where applicable. These data are compared with literature data for the commonly studied lithium salts LiClO4 and LiAsF6. Non-coulombic energy contributions to ion pair formation are evaluated and discussed in terms of ion-ion and ion-solvent interactions. RP SALOMON, M (reprint author), USA,DIV POWER SOURCES,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 27 TC 58 Z9 58 U1 0 U2 9 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0095-9782 J9 J SOLUTION CHEM JI J. Solut. Chem. PD AUG PY 1993 VL 22 IS 8 BP 715 EP 725 DI 10.1007/BF00647411 PG 11 WC Chemistry, Physical SC Chemistry GA LU451 UT WOS:A1993LU45100004 ER PT J AU WELCH, ML SMITH, KJ SKELTON, HG FRISMAN, DM YEAGER, J ANGRITT, P WAGNER, KF AF WELCH, ML SMITH, KJ SKELTON, HG FRISMAN, DM YEAGER, J ANGRITT, P WAGNER, KF TI IMMUNOHISTOCHEMICAL FEATURES IN INFLAMMATORY LINEAR VERRUCOUS EPIDERMAL NEVI SUGGEST A DISTINCTIVE PATTERN OF CLONAL DYSREGULATION OF GROWTH SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID FACTOR-XIIIA; DERMAL DENDROCYTES; PSORIASIS; EXPRESSION; CELLS; SKIN; AIDS AB Background: We studied biopsy material from four patients with inflammatory linear verrucous epidermal nevi (ILVEN) that had a psoriasiform appearance histologically and seven cases of linear epidermal nevi (LEN). Of the seven LEN, five showed hyperkeratosis, papillomatosis, and varying degrees of acanthosis; two had features of epidermolytic hyperkeratosis. Because these lesions have distinctive histologic patterns, we wanted to determine whether we could also demonstrate a distinctive pattern of immunohistochemical markers. Methods: On all 11 cases we performed immunohistochemical stains for PCNA, factor XIIIa, MAC-387, UCHL-1, and OPD-4. In addition, on one case of ILVEN we performed ICAM-1, ELAM-1, and HLA-DR stains. Results: The pattern of staining of PCNA, factor XIIIa, MAC-38 7, UCHL-1, and OPD-4 was distinctly different in ILVEN and LEN. Staining for ICAM-1 was present on keratinocytes, and ELAM-1 was present on endothelial cells in two cases of ILVEN. HLA-DR in these same two cases of ILVEN stained mainly dendritic cells in the epidermis. Conclusion: The different pattern of staining of PCNA, factor XIIIa, MAC-387, UCHL-1, and OPD-4 in LEN and ILVEN indicates a different mechanism of growth dysregulation. Stains for ICAM-1, ELAM-1, and HLA-DR in ILVEN suggest that an inability to down-regulate the inflammatory infiltrate may be important in the growth dysregulation in ILVEN. In addition, the onset of ILVEN at the time of HIV-1 infection in one patient suggests that HIV-1 infection may be one of many factors that initiates ILVEN in a susceptible person. C1 WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20306 USA. ARMED FORCES INST PATHOL, DEPT CELLULAR PATHOL, WASHINGTON, DC 20306 USA. ARMED FORCES INST PATHOL, AIDS REGISTRY, WASHINGTON, DC 20306 USA. NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20814 USA. HENRY M JACKSON FDN, WASHINGTON, DC USA. RP WELCH, ML (reprint author), WALTER REED ARMY MED CTR, DEPT DERMATOL, WASHINGTON, DC 20307 USA. FU NIAMS NIH HHS [NIAMS Y01AR00014, NIAMS Y01AR90008] NR 21 TC 10 Z9 10 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD AUG PY 1993 VL 29 IS 2 BP 242 EP 248 PN 1 PG 7 WC Dermatology SC Dermatology GA LR278 UT WOS:A1993LR27800017 PM 8101529 ER PT J AU SMITH, KJ SKELTON, HG VOGEL, P YEAGER, J BAXTER, D WAGNER, KF AF SMITH, KJ SKELTON, HG VOGEL, P YEAGER, J BAXTER, D WAGNER, KF TI EXAGGERATED INSECT BITE REACTIONS IN PATIENTS POSITIVE FOR HIV SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note ID MOSQUITO BITES; INFECTION C1 NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20814 USA. WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DERMATOL SERV, WASHINGTON, DC 20307 USA. HENRY M JACKSON FDN, WASHINGTON, DC USA. RP SMITH, KJ (reprint author), ARMED FORCES INST PATHOL, WASHINGTON, DC 20306 USA. FU NIAMS NIH HHS [NIAMS Y01AR00014, NIAMS Y01AR90008] NR 11 TC 20 Z9 20 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD AUG PY 1993 VL 29 IS 2 BP 269 EP 272 PN 1 PG 4 WC Dermatology SC Dermatology GA LR278 UT WOS:A1993LR27800026 PM 8101530 ER PT J AU BEARD, JS SMITH, KJ SKELTON, HG AF BEARD, JS SMITH, KJ SKELTON, HG TI COMBINATION CHEMOTHERAPY WITH 5-FLUOROURACIL, FOLINIC ACID, AND ALPHA-INTERFERON PRODUCING HISTOLOGIC FEATURES OF GRAFT-VERSUS-HOST DISEASE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID INDUCED ACRAL ERYTHEMA; PLANTAR ERYTHRODYSESTHESIA SYNDROME; NEUTROPHILIC ECCRINE HIDRADENITIS; SELECTIVE LOSS; THERAPY; HYPERPIGMENTATION; FLUOROURACIL; RESPONSES; INFUSION AB Fluorouracil is a common cause of acral erythema and a variety of pigmentary anomalies. These conditions are believed to be the result of a direct toxic effect or a graft-versus-host-like reaction. We describe two cases in which an erythematous eruption that evolved into hyperpigmented, hyperkeratotic lesions developed in two patients who were receiving combination chemotherapy (5-fluorouracil, folinic acid, and alpha-interferon). The histologic features included apoptotic keratinocytes with exocytosis of mononuclear cells, some showing satellitosis, and hydropic change of the basal cell layer with an interface dermatitis that was most marked within the distal eccrine duct and acrosyringium. Clinicopathologic correlation suggests that the eruption was primarily caused by involvement of the sweat glands and hair follicles. Although a direct toxic effect may play some role, the histologic features suggest that the dominant mechanism is a graft-versus-host-like or host-versus-altered-host-type reaction. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP BEARD, JS (reprint author), WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307, USA. NR 35 TC 18 Z9 18 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD AUG PY 1993 VL 29 IS 2 BP 325 EP 330 DI 10.1016/0190-9622(93)70187-X PN 2 PG 6 WC Dermatology SC Dermatology GA LR751 UT WOS:A1993LR75100011 PM 8340507 ER PT J AU KING, N FRIDLUND, KE ASKEW, EW AF KING, N FRIDLUND, KE ASKEW, EW TI NUTRITION ISSUES OF MILITARY WOMEN SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION LA English DT Article; Proceedings Paper CT SYMP ON WOMENS HEALTH AND NUTRITION RESEARCH : US GOVERNMENTAL CONCERN, AT THE 33RD ANNUAL MEETING OF THE AMERICAN COLLEGE OF NUTRITION CY OCT, 1992 CL SAN DIEGO, CA SP AMER COLL NUTR DE MILITARY WOMEN; NUTRITIONAL SURVEYS; NUTRITIONAL INTAKE; MILITARY RECOMMENDED DIETARY ALLOWANCES; MILITARY RATIONS AB Nutritional data were collected from 147 female soldiers in four surveys (two field and two dining hall studies) conducted by the US Army Research Institute of Environmental Medicine and Letterman Army Institute of Research, The 49 female soldiers observed in the field studies had suboptimal mean energy (1751 kcal), protein (52.3 g), calcium (620 mg), and iron (11.8 mg) intakes. In addition, 54 female soldiers in the dining hall studies also had lower than desirable mean iron (16.2 mg) intakes. These data suggest that nutritional problems encountered by military women are similar to those faced by their civilian counterparts, based on NHANES II and CSFII reports. Although the impact of sporadic low nutrient intakes during short 10-14-day field training exercises may be of little consequence, this may be significant when inadequate intakes occur routinely or for extended periods during military conflicts. Viable solutions to the nutritional problems of military women could include ration supplementation and nutrition education. C1 OFF SURGEON GEN,WASHINGTON,DC. RP KING, N (reprint author), USA,ENVIRONM MED RES INST,DIV MIL NUTR,SGRD,UE,OPN,NATICK,MA 01760, USA. NR 14 TC 16 Z9 16 U1 0 U2 3 PU AMER COLL NUTRITION PI NEW YORK PA C/O HOSP. JOINT DIS. 301 E. 17TH ST., NEW YORK, NY 10003 SN 0731-5724 J9 J AM COLL NUTR JI J. Am. Coll. Nutr. PD AUG PY 1993 VL 12 IS 4 BP 344 EP 348 PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA LP805 UT WOS:A1993LP80500004 PM 8409093 ER PT J AU LEBER, AP DACRE, JC THAKE, DC MAYS, DC AF LEBER, AP DACRE, JC THAKE, DC MAYS, DC TI P-CHLOROPHENYL METHYL SULFIDE, P-CHLOROPHENYL METHYL SULFOXIDE, AND P-CHLOROPHENYL METHYL SULFONE .1. ACUTE TOXICITY AND BACTERIAL MUTAGENICITY STUDIES SO JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY LA English DT Article AB An acute toxicity battery was performed on a series of three chemicals (p-chlorophenyl methyl sulfide, p-chloro-phenyl methyl sulfoxide, and p-chlorophenyl methyl sulfone) which have been identified as ground water contaminants at the U.S. Army's Rocky Mountain Arsenal near Denver. The results indicate that these materials exhibit oral LD50 values in the ranges of 400-620 mg/kg in rats and 330-880 mg/kg in mice. Following dermal exposures, only the sulfide induced death in rabbits. This agent and the sulfoxide induced central nervous system depression for a period of up to 7 days postapplication. Skin irritation potencies in rabbit tests were in the order of sulfoxide > sulfone >> sulfide, whereas ocular test results revealed irritation potencies to be sulfoxide > sulfide > sulfone. Results of guinea pig testing indicated a lack of sensitization potential for all compounds. None of the test materials induced bacterial mutations in Salmonella (five strains) assays that employed Arochlor 1254- and phenobarbital-induced S-9 rat liver activation systems. The most overt short-term effects following exposure to one or more of these agents are the ocular effects and the neurologic/lethal potentials following dermal or oral contact. C1 USA,BIOMED RES & DEV LAB,FT DETRICK,FREDERICK,MD 21702. BATTELLE MEM INST,COLUMBUS,OH 43201. NR 7 TC 0 Z9 0 U1 0 U2 4 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0730-0913 J9 J AM COLL TOXICOL JI J. Am. Coll. Toxicol. PD AUG PY 1993 VL 12 IS 4 BP 369 EP 376 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA LZ143 UT WOS:A1993LZ14300007 ER PT J AU THAKE, DC MAYS, DC LEBER, AP DACRE, JC AF THAKE, DC MAYS, DC LEBER, AP DACRE, JC TI P-CHLOROPHENYL METHYL SULFIDE, P-CHLOROPHENYL METHYL SULFOXIDE, AND P-CHLOROPHENYL METHYL SULFONE .2. SUBCHRONIC EFFECTS IN RODENTS AND RHESUS-MONKEYS SO JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY LA English DT Article ID DOSE LEVELS AB Rats, mice, and rhesus monkeys were subjected in subchronic exposures to the chemicals p-chlorophenyl methyl sulfide, p-chlorophenyl methyl sulfoxide, and p-chlorophenyl sulfone. Ninety-one-day toxicity studies were conducted by administering test chemicals to rodents at dietary concentrations of 750, 1500, and 3000 ppm. Clinical signs observed included transient central nervous system (CNS) depression, anorexia, and depressed weight gains. Minor alterations of hematologic and clinical chemistry parameters were also present. Gross and microscopic tissue findings in mice and rats included enlargement, necrotic and megalocytic changes of the liver. Damage to bronchiolar epithelium was observed in mice only at the highest exposure level. A 14-day gavage study in monkeys used daily dosages ranging from 2.5 to 80 mg/kg with an additional 15 days allotted for a recovery phase in one-half the test animals. Compound-related findings included lethality, CNS depression, and emesis. There were no significant compound-induced alterations in electrocardiographic or ophthalmic parameters. Serum blood urea nitrogen and serum glutamic pyruvic transaminase values were elevated in the highest dosage groups for the three test materials concomitant with increases in liver and kidney weights. Microscopic lesions included proliferative changes in lymph nodes, spleen, and bone marrow; hepatocellular vacuolization, degeneration, and necrosis; thyroid follicular cell hyperplasia; and degenerative lesions in gastric and intestinal epithelium. No-observable-effect levels (NOELs) were not established for any of the three test chemicals in the species tested. C1 USA,BIOMED RES & DEV LAB,FT DETRICK,FREDERICK,MD 21702. BATTELLE MEM INST,COLUMBUS,OH 43201. MAYO CLIN & MAYO FDN,MAYO MED SCH,ROCHESTER,MN 55905. NR 9 TC 1 Z9 1 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0730-0913 J9 J AM COLL TOXICOL JI J. Am. Coll. Toxicol. PD AUG PY 1993 VL 12 IS 4 BP 377 EP 395 PG 19 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA LZ143 UT WOS:A1993LZ14300008 ER PT J AU DACRE, JC LEBER, AP MAYS, DC AF DACRE, JC LEBER, AP MAYS, DC TI P-CHLOROPHENYL METHYL SULFIDE, P-CHLOROPHENYL METHYL SULFOXIDE, AND P-CHLOROPHENYL METHYL SULFONE .3. TOXICOKINETICS AND METABOLISM IN RATS AND RHESUS-MONKEYS SO JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY LA English DT Article AB Pharmacokinetic properties of p-chlorophenyl methyl sulfide, p-chlorophenyl methyl sulfoxide, and p-chlorophenyl methyl sulfone were evaluated in rats and rhesus monkeys following oral administration of C-14 radiolabeled test materials. In addition, urinary metabolite formation in treated rats was partially assessed, as was microsomal enzyme induction as determined by hexobarbital sleep time assays. All test materials were found to be rapidly absorbed following gavage dosing with a biphasic diminution of blood radiolabel in the rat. As an apparent result of higher dosage levels, rhesus monkeys exhibited both a delayed attainment of peak blood levels and a lower rate of elimination of blood C-14. A minor portion (5-7%) of urinary radioactivity from treated rats was not extractable with chloroform until incubation with deconjugation enzymes was conducted, releasing up to 50%. The values for rhesus monkeys were 15-62% and 50%, respectively; the former values are apparently elevated (relative to rat) due to saturation of conjugate-formation pathways. Decreases were observed for hexobarbital sleep times following 3-day treatment with 50 mg/kg of each of the test compounds and, consistent with hepatomegaly observed in subchronic studies, suggest induction of hepatic microsomal enzymes. The study supports evidence that these chemicals are cleared primarily via the urine in a dose-dependent manner, and are conjugated to water-soluble metabolites in both rats and rhesus monkeys. C1 BATTELLE MEM INST,COLUMBUS,OH 43201. RP DACRE, JC (reprint author), USA,BIOMED RES & DEV LAB,FT DETRICK,FREDERICK,MD 21702, USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0730-0913 J9 J AM COLL TOXICOL JI J. Am. Coll. Toxicol. PD AUG PY 1993 VL 12 IS 4 BP 397 EP 407 PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA LZ143 UT WOS:A1993LZ14300009 ER PT J AU KOLKA, MA QUIGLEY, MD BLANCHARD, LA TOYOTA, DA STEPHENSON, LA AF KOLKA, MA QUIGLEY, MD BLANCHARD, LA TOYOTA, DA STEPHENSON, LA TI VALIDATION OF A TEMPERATURE TELEMETRY SYSTEM DURING MODERATE AND STRENUOUS EXERCISE SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE EXERCISE; TELEMETRY; BODY TEMPERATURE; HUMAN ID CORE TEMPERATURE; TYMPANIC TEMPERATURE; BRAIN; HYPERTHERMIA; ESOPHAGEAL; SURGERY; HUMANS AB 1. Esophageal temperature [T(es) (18.0 +/- 6.1 min)] and pill temperature [T(hti) (25.3 +/- 9.1 min)] reached steady state faster (P < 0.05) during moderate exercise (40 min at 40% peak V(O2)) than rectal temperature [T(re) (37.3 +/- 4.6 min)] at T(a) = 29-degrees-C, T(dp) = 11-degrees-C. Steady-state exercise temperatures were lower for T(es) = 37.18 +/- 0.18-degrees-C and T(hti) = 37.20 +/- 0.32-degrees-C than T(re) = 37.46 +/- 0.15-degrees-C (P < 0.05). 2. During moderate exercise the change in core,temperature per time (slope) was greater (P < 0.05) for T(es) (0.050 +/- 0.01 3-degrees-C min-1) than T(hti), (0.031 +/- 0.014-degrees-C min-1) and T(re) (0.018 +/- 0.005-degrees-C min-1). During intense exercise the change in T(es) per minute was twice that for T(hti) and 5 times that for T(re). 3. Overall, T(hti) tracked dynamic changes in core temperature significantly faster than T(re), although T(hti) did not track dynamic changes as well or as consistently as T(es). The concept of using a temperature sensor in a pill may be useful clinically, but mobility of the pill makes this temperature measurement less suitable for research than esophageal or rectal temperature measurements. RP KOLKA, MA (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760, USA. NR 26 TC 56 Z9 56 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD AUG PY 1993 VL 18 IS 4 BP 203 EP 210 DI 10.1016/0306-4565(93)90004-D PG 8 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA LY883 UT WOS:A1993LY88300004 ER PT J AU BARRY, MJ COCKETT, ATK HOLTGREWE, HL MCCONNELL, JD SIHELNIK, SA WINFIELD, HN AF BARRY, MJ COCKETT, ATK HOLTGREWE, HL MCCONNELL, JD SIHELNIK, SA WINFIELD, HN TI RELATIONSHIP OF SYMPTOMS OF PROSTATISM TO COMMONLY USED PHYSIOLOGICAL AND ANATOMICAL MEASURES OF THE SEVERITY OF BENIGN PROSTATIC HYPERPLASIA SO JOURNAL OF UROLOGY LA English DT Article DE PROSTATIC HYPERTROPHY; SYMPTOMS; URODYNAMICS ID TRANSURETHRAL RESECTION; URODYNAMIC FINDINGS; NATURAL-HISTORY; RESIDUAL URINE; PROSTATECTOMY; HYPERTROPHY; MORTALITY; MEN; UROFLOWMETRY; REOPERATION AB In previous studies the severity of symptoms of prostatism in men with benign prostatic hyperplasia have not correlated well with prostate size, degree of bladder trabeculation, uroflowmetry or post-void residual volume. As part of a prospective cohort study of benign prostatic hyperplasia treatment effectiveness in 4 university-based urology practices, we correlated symptom severity and these commonly used measures of disease severity. Symptom severity was quantified using the American Urological Association symptom index. Analyses were based on 198 outpatients completing a standardized evaluation (84 of these men have completed 6 months of followup after treatment with prostatectomy, balloon dilation, terazosin or watchful waiting). At baseline, symptom severity was not correlated with uroflowmetry, post-void residual, prostate size and degree of bladder trabeculation. However, symptom severity was much more strongly related to overall health status than the other measures. Reduction in symptoms with treatment did correlate with improvements in uroflowmetry. This poor baseline correlation with symptoms may reflect unreliability in measurement of the physiological/anatomical variables. Alternatively, these parameters may be measuring different pathophysiological phenomena. C1 SW MED CTR,DEPT UROL,DIV UROL,DALLAS,TX. AMER UROL ASSOC,DEPT UROL,BALTIMORE,MD. UNIV IOWA,COLL MED,DEPT UROL,IOWA CITY,IA 52242. WALTER REED ARMY MED CTR,DEPT UROL,UROL SERV,WASHINGTON,DC 20307. UNIV ROCHESTER,SCH MED,DEPT UROL,ROCHESTER,NY 14627. JOHNS HOPKINS UNIV,SCH MED,DEPT UROL,BALTIMORE,MD 21205. RP BARRY, MJ (reprint author), MASSACHUSETTS GEN HOSP,CTR MED PRACTICES EVALUAT,BOSTON,MA 02114, USA. FU AHRQ HHS [HS 06336, HS 06689] NR 36 TC 279 Z9 284 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1993 VL 150 IS 2 BP 351 EP 358 PN 1 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA LM765 UT WOS:A1993LM76500018 PM 7686980 ER PT J AU SUTHERLAND, DE AF SUTHERLAND, DE TI LABCALC - A PC-COMPATIBLE SPREADSHEET TEMPLATE FOR LABORATORY CALCULATIONS SO LABORATORY MEDICINE LA English DT Article RP SUTHERLAND, DE (reprint author), DD EISENHOWER ARMY MED CTR,DEPT CLIN INVEST,CHEM SERV,FT GORDON,GA 30905, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLIN PATHOLOGISTS PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 SN 0007-5027 J9 LAB MED JI Lab. Med. PD AUG PY 1993 VL 24 IS 8 BP 525 EP 529 PG 5 WC Medical Laboratory Technology SC Medical Laboratory Technology GA LN146 UT WOS:A1993LN14600010 ER PT J AU BURGESS, EB AF BURGESS, EB TI GHOSTRIDER ONE - CARROLL,G SO LIBRARY JOURNAL LA English DT Book Review RP BURGESS, EB (reprint author), USA,CTR TRALINET,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD AUG PY 1993 VL 118 IS 13 BP 148 EP 148 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA LT263 UT WOS:A1993LT26300271 ER PT J AU BURGESS, EB AF BURGESS, EB TI THE BUTTON MAN - FREEMANTLE,B SO LIBRARY JOURNAL LA English DT Book Review RP BURGESS, EB (reprint author), USA,CTR TRALINET,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD AUG PY 1993 VL 118 IS 13 BP 149 EP 149 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA LT263 UT WOS:A1993LT26300282 ER PT J AU CAHILL, S BULUSU, S AF CAHILL, S BULUSU, S TI MOLECULAR-COMPLEXES OF EXPLOSIVES WITH CYCLODEXTRINS .1. CHARACTERIZATION OF COMPLEXES WITH THE NITRAMINES RDX, HMX AND TNAZ IN SOLUTION BY H-1-NMR SPIN-LATTICE RELAXATION-TIME MEASUREMENTS SO MAGNETIC RESONANCE IN CHEMISTRY LA English DT Article DE H-1 NMR; H-1 SPIN LATTICE RELAXATION; NITRAMINES; INCLUSION COMPLEXES; CYCLODEXTRINS ID INCLUSION COMPLEXES; DYNAMICS; C-13 AB Inclusion complex formation between the explosive molecules of the nitramine type, RDX, HMX and TNAZ, and cyclodextrins (alpha, beta and gamma) was studied in aqueous solution by means of H-1 spin-lattice relaxation time (T1) measurements. The results show that nitramines bind to cyclodextrins in solution; RDX and HMX bind most strongly to gamma-cyclodextrin whereas TNAZ binds most strongly to beta-cyclodextrin. The dynamic coupling coefficient and dissociation constant were determined for the complex of TNAZ with beta-cyclodextrin. The values obtained suggest that TNAZ forms a relatively weak complex with beta-cyclodextrin (K(d) = 1.8 x 10(-2) M) that displays considerable motion in the complex with respect to cyclodextrin (coupling coefficient = 0.23). This method of using H-1 T1 measurements for characterizing complex formation in solution, while limited to guest molecules containing a pair of protons having a fixed internuclear distance, is shown to be useful when complexation-induced chemical shifts are too small to be significant. C1 USA,ARMAMENTS RES DEV & ENGN CTR,DIV ENERGET MAT,PICATINNY ARSENAL,NJ 07806. NR 17 TC 21 Z9 21 U1 0 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0749-1581 J9 MAGN RESON CHEM JI Magn. Reson. Chem. PD AUG PY 1993 VL 31 IS 8 BP 731 EP 735 DI 10.1002/mrc.1260310808 PG 5 WC Chemistry, Multidisciplinary; Chemistry, Physical; Spectroscopy SC Chemistry; Spectroscopy GA LP887 UT WOS:A1993LP88700007 ER PT J AU HOPKINS, MA JENKINS, JT LOUGE, MY AF HOPKINS, MA JENKINS, JT LOUGE, MY TI ON THE STRUCTURE OF 3-DIMENSIONAL SHEAR FLOWS SO MECHANICS OF MATERIALS LA English DT Article; Proceedings Paper CT 2ND US / JAPAN SEMINAR ON MECHANICS OF GRANULAR MATERIALS CY AUG 05-09, 1991 CL CLARKSON UNIV, POTSDAM, NY HO CLARKSON UNIV ID GRANULAR FLOW; SMOOTH; MICROSTRUCTURE; PARTICLES; DISKS AB This paper describes an investigation of structure in moderately dilute three-dimensional shear flows. Structure is defined as a dynamic inhomogeneity or fluctuation in the spatial concentration field. Numerical experiments are performed with large numbers of identical, frictionless, inelastic spheres. The spheres are contained in a fully periodic cubic control volume. A state of shear is maintained in the control volume by moving the upper periodic image in one direction and the lower image in the opposite direction. As the coefficient of restitution of the spheres is lowered, conditions in the control volume deviate from a state of simple shear, exhibiting strong wavelike fluctuations in the concentration, stress, and velocity fields. Visual inspection of the spatial concentration field reveals a strong tendency for spheres with a low coefficient of restitution to form dense elongated clouds. The major axis of the clouds tends to align itself in the direction of the mean velocity and perpendicular to the direction of variation in the mean velocity created by the moving periodic images of the control volume. C1 CORNELL UNIV,DEPT THEORET & APPL MECH,ITHACA,NY 14853. CORNELL UNIV,SIBLEY SCH MECH & AEROSP ENGN,ITHACA,NY 14853. RP HOPKINS, MA (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 9 TC 18 Z9 18 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-6636 J9 MECH MATER JI Mech. Mater. PD AUG PY 1993 VL 16 IS 1-2 BP 179 EP 187 DI 10.1016/0167-6636(93)90041-O PG 9 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA LQ372 UT WOS:A1993LQ37200021 ER PT J AU LOUGE, MY JENKINS, JT HOPKINS, MA AF LOUGE, MY JENKINS, JT HOPKINS, MA TI THE RELAXATION OF THE 2ND MOMENTS IN RAPID SHEAR FLOWS OF SMOOTH DISKS SO MECHANICS OF MATERIALS LA English DT Article; Proceedings Paper CT 2ND US / JAPAN SEMINAR ON MECHANICS OF GRANULAR MATERIALS CY AUG 05-09, 1991 CL CLARKSON UNIV, POTSDAM, NY HO CLARKSON UNIV AB This paper compares the results of numerical simulations for two-dimensional, rapid, homogeneous shear flows of identical, smooth, inelastic disks with the predictions of Jenkins and Richman ((1988), J. Fluid Mech. 192, 313-328) for the relaxation of the second moments of the velocity distribution function following a homogeneous, but anisotropic disturbance of their steady values. For nearly elastic disks, the time-history of the relaxation is in excellent agreement with the theory in both its dense and dilute limits. However, deviations are observed in the case of inelastic particles. C1 CORNELL UNIV,DEPT THEORET & APPL MECH,ITHACA,NY 14853. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP LOUGE, MY (reprint author), CORNELL UNIV,SIBLEY SCH MECH & AEROSP ENGN,ITHACA,NY 14853, USA. NR 2 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-6636 J9 MECH MATER JI Mech. Mater. PD AUG PY 1993 VL 16 IS 1-2 BP 199 EP 203 DI 10.1016/0167-6636(93)90043-Q PG 5 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA LQ372 UT WOS:A1993LQ37200023 ER PT J AU RONG, FC HARVEY, JF POINDEXTER, EH GERARDI, GJ AF RONG, FC HARVEY, JF POINDEXTER, EH GERARDI, GJ TI IDENTIFICATION AND PROPERTIES OF PB-LIKE CENTERS IN PHOTOLUMINESCENT POROUS SILICON SO MICROELECTRONIC ENGINEERING LA English DT Article; Proceedings Paper CT 8TH BIENNIAL CONF ON INSULATING FILMS ON SEMICONDUCTORS CY JUN 02-05, 1993 CL DELFT, NETHERLANDS SP ELSEVIER, DELFT UNIV TECHNOL, FDN FUNDAMENTAL STUDIES MATTER, PHILIPS RES, COMMISS EUROPEAN COMMUNITIES AB A paramagnetic defect in luminescent porous Si was observed at concentration 10(15) cm-2. The g-values, hyperfine and superhyperfine structure identify it as a slight variant of the planar-surface P(b0) center (.Si=Si3). Its complete g-map reflects multiply-oriented microcrystal faces on a lattice aligned with the substrate. It seems not to be the only luminescence recombination center in porous Si. RP RONG, FC (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-9317 J9 MICROELECTRON ENG JI Microelectron. Eng. PD AUG PY 1993 VL 22 IS 1-4 BP 147 EP 150 DI 10.1016/0167-9317(93)90148-X PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Optics; Physics, Applied SC Engineering; Science & Technology - Other Topics; Optics; Physics GA LV299 UT WOS:A1993LV29900029 ER PT J AU KIRCHNER, KW LUCEY, GK GEIS, J AF KIRCHNER, KW LUCEY, GK GEIS, J TI COPPER SOLDER INTERMETALLIC GROWTH-STUDIES SO MICROSCOPY RESEARCH AND TECHNIQUE LA English DT Article DE INTERMETALLIC COMPOUNDS; ESEM; SEM ID COMPOUND GROWTH; SOLDERABILITY AB Copper samples, hot solder (eutectic) dipped and thermally aged, were cross-sectioned and placed in an environmental scanning electronic microscope (ESEM). While in the ESEM the samples were heated for approximately 2.5 h at 170-degrees-C to stimulate the growth of additional Cu/Sn intermetallic compound. The intent of the study was to obtain a continuous real-time videotape record of the diffusion process and compare the observations to static SEM images reported to represent long-term, naturally aged intermetallic growth. The video obtained allows the observation of the diffusion process and relativistic growth phenomena at the Cu, Cu3Sn, Cu6Sn5, and solder interfaces as well as effects on the bulk Cu and solder. Effects contrary to earlier reports were observed; for example, growth rates of Cu3Sn were found to greatly exceed those of Cu6Sn5. (C) 1993 Wiley-Liss, Inc.* C1 TECH INT,CHESHIRE,CT 06410. RP KIRCHNER, KW (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 6 TC 3 Z9 4 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 1059-910X J9 MICROSC RES TECHNIQ JI Microsc. Res. Tech. PD AUG PY 1993 VL 25 IS 5-6 BP 503 EP 508 DI 10.1002/jemt.1070250522 PG 6 WC Anatomy & Morphology; Biology; Microscopy SC Anatomy & Morphology; Life Sciences & Biomedicine - Other Topics; Microscopy GA LN846 UT WOS:A1993LN84600021 PM 8400445 ER PT J AU THOMSON, JD LISECKI, EJ AF THOMSON, JD LISECKI, EJ TI INJURIES AND DEATHS FROM COLLECTING WAR SOUVENIRS IN OPERATION DESERT-STORM SO MILITARY MEDICINE LA English DT Article AB Data were collected on 22 patients who sustained injuries or death from collecting war souvenirs during Operation Desert Storm from December 1990 to May 1991. Nine of 16 patients injured and 3 of 6 patients killed were non-combat arms personnel. Non-combat personnel closely followed combat units, and subsequently were exposed to unexploded ordnance. Combat and non-combat personnel should be warned that innocent-appearing material on or near a battlefield may be an explosive device. They should be instructed concerning the types of ordnance used, as well as the dangers of unexploded ordnance. RP THOMSON, JD (reprint author), TRIPLER ARMY MED CTR,ORTHOPED SURG SERV,HONOLULU,HI 96859, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1993 VL 158 IS 8 BP 505 EP 507 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA LT492 UT WOS:A1993LT49200011 PM 8414069 ER PT J AU FITZGERALD, ML BRAUDAWAY, CA LEEKS, D PADGETT, MB SWARTZ, AL SAMTER, J GARYSTEPHENS, M DELLINGER, NF AF FITZGERALD, ML BRAUDAWAY, CA LEEKS, D PADGETT, MB SWARTZ, AL SAMTER, J GARYSTEPHENS, M DELLINGER, NF TI DEBRIEFING - A THERAPEUTIC INTERVENTION SO MILITARY MEDICINE LA English DT Article AB An injured soldier may not have the benefit of the mental health interventions available to other combatants. A team of psychiatric liaison nurses report on the therapeutic effects of debriefing in the treatment of the traumatically injured soldier. Debriefing not only affords an opportunity for the patient to share thoughts and feelings about the trauma, but provides additional data regarding effective coping mechanisms. This information also assists the health care team to identify individuals at risk for developing post-traumatic stress disorder. Patient teaching can then be directed toward helping each individual recognize the signs and symptoms of stress unique to him/her and mobilize a plan for obtaining assistance. Debriefing also assists the treatment team in identifying a soldier's specific information deficits regarding the system, i.e., medical boards and convalescent leaves. RP FITZGERALD, ML (reprint author), WALTER REED ARMY MED CTR,PEDIAT CONSULTAT LIAISON SERV,WASHINGTON,DC 20307, USA. NR 0 TC 11 Z9 11 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1993 VL 158 IS 8 BP 542 EP 545 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA LT492 UT WOS:A1993LT49200019 PM 8414077 ER PT J AU THARION, WJ RICE, V SHARP, MA MARLOWE, BE AF THARION, WJ RICE, V SHARP, MA MARLOWE, BE TI THE EFFECTS OF LITTER CARRYING ON RIFLE SHOOTING SO MILITARY MEDICINE LA English DT Article AB This study investigated whether the use of a shoulder harness would affect shooting accuracy after patient litter carrying. Two- and four-person teams, 12 male and 9 female soldiers, fired at targets before and after (1) a 15-minute bout of rapid, short litter carries and lifts, and (2) a moderate speed 30-minute litter carry with and without a harness for both types of carries. Shooting accuracy was 10% poorer (p < 0.05) after the 15-minute bout (chiBAR +/- SD = 8.9 +/- 1.9 mm) than after the 30-minute carry (8.1 +/- 1.7 mm). Four-person teams using litter-carriage harnesses had 17% tighter shot groups (45.5 +/- 30.4 mm2) (p < 0.05) than four-person teams that did not use harnesses (54.5 +/- 26.1 MM2) and two-person teams with (56.3 +/- 29.1 mm2) or without harnesses (54.9 +/- 30.7 mm2). The harness can potentially improve shooting accuracy after litter carrying. RP THARION, WJ (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1993 VL 158 IS 8 BP 566 EP 570 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA LT492 UT WOS:A1993LT49200026 PM 8414084 ER PT J AU CARDINAL, PA AF CARDINAL, PA TI ATLS AND THE GULF-WAR SO MILITARY MEDICINE LA English DT Letter RP CARDINAL, PA (reprint author), USA,DEPT PRIMARY CARE & COMMUNITY MED,FT MONMOUTH,NJ 07703, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1993 VL 158 IS 8 BP A5 EP A5 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA LT492 UT WOS:A1993LT49200001 PM 8414065 ER PT J AU CLEGG, TA AF CLEGG, TA TI DEBT AND DESERT SHIELD STORM SO MILITARY MEDICINE LA English DT Letter RP CLEGG, TA (reprint author), USA,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1993 VL 158 IS 8 BP A7 EP A7 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA LT492 UT WOS:A1993LT49200006 ER PT J AU CLOONAN, CC YESKEY, KS AF CLOONAN, CC YESKEY, KS TI ATLS AND THE GULF-WAR SO MILITARY MEDICINE LA English DT Letter RP CLOONAN, CC (reprint author), USA,WASHINGTON,DC 20310, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1993 VL 158 IS 8 BP A5 EP A6 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA LT492 UT WOS:A1993LT49200002 PM 8267762 ER PT J AU LAPIANA, FG AF LAPIANA, FG TI ATLS AND THE GULF-WAR SO MILITARY MEDICINE LA English DT Letter RP LAPIANA, FG (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1993 VL 158 IS 8 BP A6 EP A6 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA LT492 UT WOS:A1993LT49200004 PM 8414066 ER PT J AU MOUL, JW AF MOUL, JW TI FATHER OF UROLOGY - REPLY SO MILITARY MEDICINE LA English DT Letter RP MOUL, JW (reprint author), USA,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1993 VL 158 IS 8 BP A8 EP A8 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA LT492 UT WOS:A1993LT49200009 ER PT J AU PARKER, M BOSSCHER, J BARNHILL, D PARK, R AF PARKER, M BOSSCHER, J BARNHILL, D PARK, R TI OVARIAN MANAGEMENT DURING RADICAL HYSTERECTOMY IN THE PREMENOPAUSAL PATIENT SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID CERVIX; CARCINOMA AB Objective: To determine whether the ovaries should be retained or removed in premenopausal women undergoing radical hysterectomies for cervical carcinoma. Methods: Questionnaires were sent to all women who had radical hysterectomies without further therapy for cervical carcinoma at our institution over a 16-year period. Those who had retained ovarian tissue were asked to have serum gonadotropin levels measured. Results: Eighty-four of 124 eligible women (68%) responded. Sixty-eight respondents were premenopausal at the time of surgery. Thirty-eight had a bilateral salpingo-oophorectomy (BSO), 20 had one ovary preserved, and ten retained both ovaries. Six of 30 (20%) who retained ovaries developed early hormonal failure. Two of these 30 (7%) required oophorectomies subsequently. Twenty-seven of 38 BSO patients (71%) were compliant with their hormone replacement regimens. Fourteen of 15 women (93%) age 40 or younger were compliant, whereas 13 of 23 (57%) over age 40 were compliant (P < .05). Twenty-three of 34 BSO respondents (68%) reported improved or unchanged sexual relations, compared with 24 of 27 (89%) who retained ovaries (P > .05). Conclusions: Twenty-seven percent of our premenopausal women with retained ovaries have experienced early loss of hormonal function or required subsequent oophorectomies. For an accurate estimate of ovarian longevity, all patients would have to be followed through menopause. Compliance in taking hormone medication was high in our young patients. Sexual function was not adversely affected following castration. A hypothetical cost comparison favored removing, rather than retaining, the ovaries. We recommend that elective BSO be performed on most premenopausal women undergoing radical hysterectomies for cervical carcinoma. RP PARKER, M (reprint author), WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 6 TC 13 Z9 13 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD AUG PY 1993 VL 82 IS 2 BP 187 EP 190 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA LP372 UT WOS:A1993LP37200005 PM 8336862 ER PT J AU JOHNSON, JL RITTER, D AF JOHNSON, JL RITTER, D TI OBSERVATION OF PERIODIC-WAVES IN A PULSE-COUPLED NEURAL-NETWORK SO OPTICS LETTERS LA English DT Article AB A pulse-coupled neural network was implemented, for the first time to our knowledge, in a hybrid electro-optical laboratory demonstration system. Dynamic coherent traveling-wave patterns were observed that repeated their spatial patterns at each locality with a period that depended on the local input pattern and strength. Coherence and periodicity were maintained far beyond the physical limits of the linking receptive fields, suggesting a new mechanism for information transmission in a network with limited local connectivity. With no linking, the output became chaotic because the relative phases increased linearly in time. C1 UNIV ERLANGEN NURNBERG,W-8520 ERLANGEN,GERMANY. RP JOHNSON, JL (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 9 TC 91 Z9 124 U1 1 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD AUG 1 PY 1993 VL 18 IS 15 BP 1253 EP 1255 DI 10.1364/OL.18.001253 PG 3 WC Optics SC Optics GA LP287 UT WOS:A1993LP28700017 PM 19823349 ER PT J AU RABIN, J AF RABIN, J TI VERNIER ACUITY THROUGH NIGHT-VISION GOGGLES SO OPTOMETRY AND VISION SCIENCE LA English DT Article DE NIGHT VISION GOGGLES; IMAGE INTENSIFIERS; VERNIER ACUITY; CONTRAST SENSITIVITY AB Night vision goggles (NVG's) are being used increasingly in military and civilian environments. Despite the use of these devices, relatively few tests exist to assess visual performance through NVG's. Hyperacuity tasks may provide a sensitive index of performance through night vision devices. In this study, grating vernier acuity was measured through NVG's. As reported previously, a power law relation was observed between vernier acuity and stimulus contrast. Comparison of vernier acuity with and without NVG's indicated that performance is limited by the contrast transfer of the device. Vernier acuity measurements can be used to assess the quality of vision and quantity of contrast transferred through night vision devices. RP RABIN, J (reprint author), USA,AEROMED RES LAB,SGRD UAS VS,POB 620577,FT RUCKER,AL 36362, USA. NR 0 TC 5 Z9 5 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1040-5488 J9 OPTOMETRY VISION SCI JI Optom. Vis. Sci. PD AUG PY 1993 VL 70 IS 8 BP 689 EP 691 DI 10.1097/00006324-199308000-00019 PG 3 WC Ophthalmology SC Ophthalmology GA LR740 UT WOS:A1993LR74000019 PM 8414393 ER PT J AU CATTERLIN, RK THRONDSON, RR AF CATTERLIN, RK THRONDSON, RR TI IODOFORM GAUZE WITH A RADIOPAQUE FILAMENT SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS LA English DT Letter RP CATTERLIN, RK (reprint author), USA,DENT ACT,FT HOOD,TX, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD AUG PY 1993 VL 76 IS 2 BP 257 EP 257 DI 10.1016/0030-4220(93)90215-P PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LT505 UT WOS:A1993LT50500026 PM 8361742 ER PT J AU DIGGS, CL BALLOU, WR MILLER, LH AF DIGGS, CL BALLOU, WR MILLER, LH TI THE MAJOR MEROZOITE SURFACE PROTEIN AS A MALARIA VACCINE TARGET SO PARASITOLOGY TODAY LA English DT Article ID MONOCLONAL-ANTIBODY RECOGNIZES; PLASMODIUM-FALCIPARUM; AOTUS MONKEYS; ANTIGEN GENE; PARASITE; RECOMBINANT; IMMUNIZATION; PRECURSOR; INVASION; EPITOPE AB Experts gathered for two days in the summer of 1992 at the National Institutes of Health and the Walter Reed Army Institute of Research to discuss the potential of a major merozoite surface protein (MSP-1) in malaria vaccine development. The participants came in an exemplary spirit of co-operation, sharing ideas and unpublished data toward the common goal of a malaria vaccine. Their conclusions are presented here by Carter Diggs, Ripley Ballou and Lou Miller. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. NIAID,MALARIA RES LAB,BETHESDA,MD 20892. RP DIGGS, CL (reprint author), ATLANTIC RESOURCES CORP,1601 N KENT ST,SUITE 1101,ARLINGTON,VA 22209, USA. NR 32 TC 49 Z9 51 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0169-4758 J9 PARASITOL TODAY JI Parasitol. Today PD AUG PY 1993 VL 9 IS 8 BP 300 EP 302 DI 10.1016/0169-4758(93)90130-8 PG 3 WC Parasitology SC Parasitology GA LN898 UT WOS:A1993LN89800014 PM 15463788 ER PT J AU KAUFMAN, D WESENSTEN, NJ PEARSON, NR KAMIMORI, GH BALKIN, TJ AF KAUFMAN, D WESENSTEN, NJ PEARSON, NR KAMIMORI, GH BALKIN, TJ TI ALTITUDE AND TIME OF DAY EFFECTS ON EEG SPECTRAL PARAMETERS SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE ALTITUDE; TIME OF DAY; SPECTRAL ANALYSIS AB Electroencephalographic (EEG) recordings were obtained from nine male subjects at sea level and again following rapid ascent to high altitude (4300 meters) at 0900, 1600, and 1830 h. Electroencephalographic data were subjected to Fast Fourier Transformation and analyzed for beta, spindle, alpha, theta, delta, and total amplitudes. Total amplitude increased from baseline to altitude while relative theta (absolute theta/total amplitude) decreased from baseline to altitude. Amplitude for absolute and relative spindle and total amplitude increased across the day. The results indicate that altitude exerts an effect on the waking electroencephalogram which can be quantified via spectral analysis. C1 WALTER REED ARMY INST RES,DEPT BEHAV BIOL,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. NR 13 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD AUG PY 1993 VL 54 IS 2 BP 283 EP 287 DI 10.1016/0031-9384(93)90112-S PG 5 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA LM882 UT WOS:A1993LM88200014 PM 8372122 ER PT J AU GRIFFITH, J GREENLEES, J AF GRIFFITH, J GREENLEES, J TI GROUP COHESION AND UNIT VERSUS INDIVIDUAL DEPLOYMENT OF UNITED-STATES-ARMY RESERVISTS IN OPERATION DESERT-STORM SO PSYCHOLOGICAL REPORTS LA English DT Article AB The common background and reduced disruption among personnel in Army Reserve and Army National Guard units are presumed to make these units very cohesive. The recent Persian Gulf War often necessitated reassigning soldiers from their original units to others to obtain the adequate number of personnel and the right mix of military occupational specialties in deployed units. This study examined the effects of reassigning privates through staff sergeants (E1-E6), some of whom were deployed with their units (N = 1,572) and some of whom were deployed individually with another unit (N = 209) during Operation Desert Storm. Possible benefits of keeping soldiers in intact units during deployment included greater civilian employers' support during deployment, fewer administrative procedural problems affecting soldiers (e.g., paying the soldier), and greater community support after soldiers' return. Individually deployed soldiers may have been motivated to go with another unit during deployment (e.g., perceptions of greater readiness in individual military and combat skill and lower readiness of their unit). Being individually deployed was not associated with lower organizational commitment (Army Reserve career intent) or future readiness (willingness to report for future mobilizations and perceived family support). C1 WESTAT CORP,ROCKVILLE,MD. USA,WASHINGTON,DC 20310. NR 6 TC 5 Z9 5 U1 0 U2 3 PU PSYCHOLOGICAL REPORTS PI MISSOULA PA P O BOX 9229, MISSOULA, MT 59807 SN 0033-2941 J9 PSYCHOL REP JI Psychol. Rep. PD AUG PY 1993 VL 73 IS 1 BP 272 EP 274 PG 3 WC Psychology, Multidisciplinary SC Psychology GA LQ451 UT WOS:A1993LQ45100049 ER PT J AU PEOPLES, GE SCHOOF, DD ANDREWS, JVR NORTON, JA KIM, B ALEXANDER, HR GOEDEGEBUURE, PS EBERLEIN, TJ AF PEOPLES, GE SCHOOF, DD ANDREWS, JVR NORTON, JA KIM, B ALEXANDER, HR GOEDEGEBUURE, PS EBERLEIN, TJ TI T-CELL RECOGNITION OF OVARIAN-CANCER SO SURGERY LA English DT Article; Proceedings Paper CT 54TH ANNUAL MEETING OF THE SOC OF UNIVERSITY SURGEONS CY FEB 11-13, 1992 CL SEATTLE, WA SP SOC UNIV SURGEONS ID TUMOR-INFILTRATING LYMPHOCYTES; AUTOLOGOUS TUMOR; MALIGNANT ASCITES; CLONAL ANALYSIS; HLA-A; MELANOMA; INTERLEUKIN-2; CARCINOMA; IMMUNOTHERAPY; ACTIVATION AB Background. The existence of a tumor-specific T-cell immune response to human malignant melanoma has been well documented In contrast, the existence of tumor-specific cytotoxic T lymphocyte to ovarian cancer remains controversial despite the abundant lymphocytic infiltrates in the malignant ascites and solid tumor of these patients. Methods. Tumor-associated lymphocytes (TAL) from the malignant ascites and tumor-infiltrating lymphocytes (TIL) from the solid tumors were isolated from six untreated patients with ovarian cancer. TAL and TIL were grown with initial anti-cluster of differentiation of T cells (CD3), low-dose interleukin-2, and tumor stimulation. T-cell lines were analyzed in functional studies. Results. At 5 weeks, TAL and TIL from five of six patients were >50% CD8+, and one of six was > 70% CD4+. In all five pairs of CD8 positive cultures, both TAL and TIL exhibited high levels of tumor-specific cytotoxicity for ascitic and solid tumor, respectively. T-cell recognition of tumor was mediated through the T-cell receptor-CD3 complex and was human leukocyte antigen class I restricted TAL and TIL lysed autologous ascitic tumor equally well; however, TAL-mediated tumoricidal activity against autologous solid tumor was consistently and significantly poorer than TIL-mediated killing. Conclusions. Tumor-specific cytotoxic T lymphocytes can be expanded from both TAL and TIL. However, TAL do not kill solid tumor as efficiently as TIL. This suggests the requirement of TIL, or a combination of TIL and TAL, for effective immunotherapy. C1 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT SURG,DIV SURG ONCOL,75 FRANCIS ST,BOSTON,MA 02115. USA,MED DEPT STUDENT DETACHMENT,FT SAM HOUSTON,TX 78234. FU NCI NIH HHS [CA 09535, R01 CA45484] NR 22 TC 63 Z9 63 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0039-6060 J9 SURGERY JI Surgery PD AUG PY 1993 VL 114 IS 2 BP 227 EP 234 PG 8 WC Surgery SC Surgery GA LQ384 UT WOS:A1993LQ38400013 PM 8342128 ER PT J AU SHAVER, TR MANISCALCOTHEBERGE, M SWANSON, SJ KOCANDRLE, V AF SHAVER, TR MANISCALCOTHEBERGE, M SWANSON, SJ KOCANDRLE, V TI INTERNAL MARSUPIALIZATION AFTER LAPAROSCOPY FOR LYMPHOCELES AFTER RENAL-TRANSPLANTATION SO SURGERY GYNECOLOGY & OBSTETRICS LA English DT Article RP SHAVER, TR (reprint author), WALTER REED ARMY MED CTR,ORGAN TRANSPLANT SERV,WASHINGTON,DC 20307, USA. NR 2 TC 4 Z9 4 U1 0 U2 0 PU FRANKLIN H MARTIN FOUNDATION PI CHICAGO PA 55 E ERIE ST, CHICAGO, IL 60611 SN 0039-6087 J9 SURG GYNECOL OBSTET JI Surg. Gynecol. Obstet. PD AUG PY 1993 VL 177 IS 2 BP 187 EP 187 PG 1 WC Obstetrics & Gynecology; Surgery SC Obstetrics & Gynecology; Surgery GA LQ640 UT WOS:A1993LQ64000015 PM 8342101 ER PT J AU CARTLAND, HE NICKOLAISEN, SL AF CARTLAND, HE NICKOLAISEN, SL TI CO INTERNAL EXCITATION IN THE PHOTODISSOCIATION OF CR(CO)6 AT 278 NM SO CHEMICAL PHYSICS LETTERS LA English DT Article ID EXCIMER LASER PHOTOLYSIS; GROUP-6 METAL-CARBONYLS; GAS-PHASE; CHROMIUM HEXACARBONYL; INFRARED CHEMILUMINESCENCE; ELECTRONIC-STRUCTURE; ENERGY DISPOSAL; MOLECULAR-BEAM; SPECTROSCOPY; DISSOCIATION AB Time-resolved infrared diode laser spectroscopy has been used to probe CO internal excitation in the photodissociation of Cr(CO)6 at 278 nm. At the high fluence level of these experiments, CO state distributions are not consistent with a statistical model of single-photon absorption. A simple Franck-Condon treatment, assuming multiphoton absorption into a dissociative continuum, qualitatively describes the observed CO vibrational distribution. RP CARTLAND, HE (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 21 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD JUL 30 PY 1993 VL 210 IS 4-6 BP 327 EP 332 DI 10.1016/0009-2614(93)87031-W PG 6 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA LP038 UT WOS:A1993LP03800004 ER PT J AU MCQUAID, MJ LEMIRE, GW SAUSA, RC AF MCQUAID, MJ LEMIRE, GW SAUSA, RC TI OBSERVATION AND ANALYSIS OF ROTATIONALLY RESOLVED (B)OVER-TILDE-(X)OVER-TILDE ELECTRONIC-TRANSITIONS OF CD-AR SO CHEMICAL PHYSICS LETTERS LA English DT Article ID SHELL VANDERWAALS COMPLEXES; DIATOMIC MOLECULE; SPECTROSCOPY; DYNAMICS; STATE AB The CD-Ar van der Waals complex has been generated in the gas phase by the 248 nm photolysis of CDBr3 entrained in a supersonic jet of argon. Rotationally resolved spectra associated with the complex have been observed by laser-induced fluorescence in the vicinity of the CD B2SIGMA-X 2PI (1, 0) band near 366 nm. Bands at 27310.7 and 27327.8 cm-1 are rotationally analyzed using computer simulations, and assigned as (1, 0(0), 0) and (1, 1rho, 0), respectively. The vibronic structure of the CD-Ar excited states has also been analyzed using a model based on hindered internal rotation. The results are compared to those reported for CH-Ar. C1 USA,RES LAB,AMSRL WT PC,ABERDEEN PROVING GROUND,MD 21010. NR 19 TC 15 Z9 15 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD JUL 30 PY 1993 VL 210 IS 4-6 BP 350 EP 354 DI 10.1016/0009-2614(93)87035-2 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA LP038 UT WOS:A1993LP03800008 ER PT J AU WEISS, RB VOGELZANG, NJ PETERSON, BA PANASCI, LC CARPENTER, JT GAVIGAN, M SARTELL, K FREI, E MCINTYRE, OR AF WEISS, RB VOGELZANG, NJ PETERSON, BA PANASCI, LC CARPENTER, JT GAVIGAN, M SARTELL, K FREI, E MCINTYRE, OR TI A SUCCESSFUL SYSTEM OF SCIENTIFIC-DATA AUDITS FOR CLINICAL-TRIALS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID MISCONDUCT; PROGRAM AB Objective.-To report on data collected during on-site audits of source documents in the Cancer and Leukemia Group B (CALGB). Design.-A retrospective review of audit reports in four audit cycles. Setting.-A cooperative group of institutions conducting clinical trials in cancer treatment. Participants.-Patients taking part in clinical trials at collaborating CALGB institutions, members of the CALGB Data Audit Committee, and group chairmen of CALGB. Main Outcome Measure.-The results of 691 institutional audits conducted by the CALGB in 1982 through 1992 with comparisons of main CALGB institutions vs affiliates. Results.-In four full reviews of all participating institutions in the CALGB, 3787 patients have had their on-site medical records compared with data submitted to the CALGB Data Management Center. Compliance with federal regulations for oversight by an institutional review board improved from a deficiency rate of 28.0% among the main institutions and 49.6% of the affiliate institutions in the first audit cycle to respective figures of 13.3% and 28.2% in the fourth cycle. Consent form deficiencies also dropped overall from 18.5% in the first cycle to 3.9% in the fourth. Patient eligibility was verified by auditors in 94.5%, and assessment of tumor changes in response to treatment was verified in 96.4% in the fourth cycle; both figures were only slightly lower in the first cycle. Two instances of scientific impropriety were discovered for a rate of only 0.28% of all audits. Both occurred prior to 1984, and none have occurred since. Major protocol deviations in drug dosing have held steady at about 11% over four audit cycles. Over the 11-year period of audits, three main institutions and 96 affiliate institutions have discontinued CALGB membership due solely, or at least partly, to unfavorable audit results. Conclusion.-Scientific improprieties have occurred very rarely in clinical trials conducted by the CALGB. Protocol compliance in assessing patient eligibility and tumor responses has been high. Attention to administrative matters of consent forms, institutional review board approval, and ancillary data submission has measurably improved in the CALGB, which is at least partly due to the pressure from this on-site peer review of investigator performance. C1 MCGILL CANC CTR,DEPT MED,MONTREAL,PQ,CANADA. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. UNIV CHICAGO,DEPT MED,CHICAGO,IL 60637. CANC & LEUKEMIA GRP B,CENT OFF,LEBANON,NH. UNIV MINNESOTA,DEPT MED,MINNEAPOLIS,MN 55455. UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294. UNIV N CAROLINA,DEPT MED,CHAPEL HILL,NC 27514. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV MED ONCOL,BOSTON,MA 02115. DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT MED,HANOVER,NH 03756. RP WEISS, RB (reprint author), WALTER REED ARMY MED CTR,DEPT MED,MED ONCOL SECT,WASHINGTON,DC 20307, USA. FU NCI NIH HHS [CA 16450, CA 26806, CA 41287] NR 17 TC 52 Z9 53 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUL 28 PY 1993 VL 270 IS 4 BP 459 EP 464 DI 10.1001/jama.270.4.459 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA LN426 UT WOS:A1993LN42600024 PM 8320783 ER PT J AU DUREE, GC SHULTZ, JL SALAMO, GJ SEGEV, M YARIV, A CROSIGNANI, B DIPORTO, P SHARP, EJ NEURGAONKAR, RR AF DUREE, GC SHULTZ, JL SALAMO, GJ SEGEV, M YARIV, A CROSIGNANI, B DIPORTO, P SHARP, EJ NEURGAONKAR, RR TI OBSERVATION OF SELF-TRAPPING OF AN OPTICAL BEAM DUE TO THE PHOTOREFRACTIVE EFFECT SO PHYSICAL REVIEW LETTERS LA English DT Article ID MEDIA; SOLITONS AB We report on the first observation of self-trapping of an optical beam due to the photorefractive effect. The self-trapping occurs at microwatt light power levels, is intensity independent, and results in significant spatial pulse reshaping. C1 CALTECH,DEPT APPL PHYS,PASADENA,CA 91125. UNIV LAQUILA,DIPARTIMENTO FIS,I-67100 LAQUILA,ITALY. FDN UGO BORDONI,ROME,ITALY. USA,RES LAB,FT BELVOIR,VA 22060. ROCKWELL INT CORP,CTR SCI,THOUSAND OAKS,CA 91360. RP DUREE, GC (reprint author), UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701, USA. NR 12 TC 512 Z9 565 U1 0 U2 18 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD JUL 26 PY 1993 VL 71 IS 4 BP 533 EP 536 DI 10.1103/PhysRevLett.71.533 PG 4 WC Physics, Multidisciplinary SC Physics GA LP045 UT WOS:A1993LP04500016 ER PT J AU MERRILL, GA BUTLER, M HOROWITZ, PM AF MERRILL, GA BUTLER, M HOROWITZ, PM TI LIMITED TRYPTIC DIGESTION NEAR THE AMINO-TERMINUS OF BOVINE LIVER RHODANESE PRODUCES ACTIVE ELECTROPHORETIC VARIANTS WITH ALTERED REFOLDING SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID FORMS; PROTEINS; ENZYME AB When the enzyme rhodanese was partially digested by immobilized trypsin, it retained greater than 50% of its original activity although less than 10% of the undigested enzyme remained. The predominant daughter species were two 31-kDa polypeptides whose amino termini corresponded to either residue 44 or 45 of the enzyme's sequence. Following digestion, charged species were isolated by ion exchange chromatography. Denaturing electrophoresis revealed that a 4-kDa peptide remained associated with the 31-kDa fragment. This 4-kDa peptide appears to correspond to the amino-terminal 45 residues of rhodanese. Further proteolysis gave a 2.5-kDa peptide that dissociated under non-denaturing conditions without apparent change in migration of the 31-kDa fragment on SDS gels. Refolding of undigested, urea-denatured rhodanese restored much of its activity. Similar treatment of rhodanese following limited tryptic digestion resulted in no regain of activity. Refolding of a mixture of intact and digested rhodanese resulted in regain of activity appropriate for the amount of intact rhodanese in the sample, indicating that clipped rhodanese does not inhibit refolding of intact rhodanese. It is concluded that portions of the amino terminus of rhodanese are important in the enzyme's folding, but are not essential for the enzyme's sulfurtransferase activity. C1 UNIV TEXAS,HLTH SCI CTR,DEPT BIOCHEM,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,CTR DEV & APPLICAT BIOANALYT METHODS,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,DEPT CLIN INVEST,FT SAM HOUSTON,TX 78234. FU NIEHS NIH HHS [ES05729]; NIGMS NIH HHS [GM25177] NR 26 TC 9 Z9 9 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD JUL 25 PY 1993 VL 268 IS 21 BP 15611 EP 15620 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA LN305 UT WOS:A1993LN30500045 PM 8340386 ER PT J AU CLAYBAUGH, JR UYEHARA, CFT AF CLAYBAUGH, JR UYEHARA, CFT TI METABOLISM OF NEUROHYPOPHYSEAL HORMONES SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID MELANOCYTE-STIMULATING HORMONE; PERFUSED RAT-KIDNEY; STOP-FLOW ANALYSIS; ARGININE-VASOPRESSIN; DIABETES-INSIPIDUS; CIRCULATING VASOPRESSINASE; AMNIOTIC-FLUID; GUINEA-PIG; CLEARANCE; OXYTOCIN RP CLAYBAUGH, JR (reprint author), TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859, USA. NR 70 TC 13 Z9 13 U1 0 U2 3 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD JUL 22 PY 1993 VL 689 BP 250 EP 268 DI 10.1111/j.1749-6632.1993.tb55552.x PG 19 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA LX020 UT WOS:A1993LX02000021 PM 8373016 ER PT J AU LINDBERG, JD DOUGLASS, RE GARVEY, DM AF LINDBERG, JD DOUGLASS, RE GARVEY, DM TI IMAGINARY REFRACTIVE-INDEX OF BUCKYBALLS SO APPLIED OPTICS LA English DT Note AB The UV, visible, and IR imaginary refractive indexes Of C60 are determined and compared with that of carbon soot. C1 USA, ATMOSPHER SCI LAB, WHITE SANDS MISSILE RANGE, NM 88002 USA. RP LINDBERG, JD (reprint author), SCI & TECHNOL CORP, POB 7390, HAMPTON, VA 23666 USA. NR 6 TC 1 Z9 1 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 1993 VL 32 IS 21 BP 3921 EP 3922 PG 2 WC Optics SC Optics GA LN837 UT WOS:A1993LN83700017 PM 20830026 ER PT J AU MAYEWSKI, PA MEEKER, LD MORRISON, MC TWICKLER, MS WHITLOW, SI FERLAND, KK MEESE, DA LEGRAND, MR STEFFENSEN, JP AF MAYEWSKI, PA MEEKER, LD MORRISON, MC TWICKLER, MS WHITLOW, SI FERLAND, KK MEESE, DA LEGRAND, MR STEFFENSEN, JP TI GREENLAND ICE CORE SIGNAL CHARACTERISTICS - AN EXPANDED VIEW OF CLIMATE-CHANGE SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID NITRATE CONCENTRATIONS; VOLCANIC-ERUPTIONS; TIME-SERIES; SPACED DATA; RECORDS; SULFATE; IMPACT; SNOW AB The last millenium of Earth history is of particular interest because it documents the environmental complexities of both natural variability and anthropogenic activity. We have analyzed the major ions contained in the Greenland Ice Sheet Project 2 (GISP 2) ice core from the present to approximately 674 A.D. to yield an environmental reconstruction for this period that includes a description of nitrogen and sulfur cycling, volcanic emissions, sea salt and terrestrial influences. We have adapted and extended mathematical procedures for extracting sporadic (e.g., volcanic) events, secular trends, and periodicities found in the data sets. Finally, by not assuming that periodic components (signals) were ''stationary'' and by utilizing evolutionary spectral analysis, we were able to reveal periodic processes in the climate system which change in frequency, ''turn on,'' and ''turn off'' with other climate transitions such as that between the little ice age and the medieval warm period. C1 COLD REG RES & ENGN LAB,HANOVER,NH. LAB GLACIOL & GEOPHYS ENVIRONN,ST MARTIN DHERES,FRANCE. UNIV COPENHAGEN,INST GEOPHYS,DEPT GLACIOL,DK-1168 COPENHAGEN,DENMARK. UNIV NEW HAMPSHIRE,DEPT MATH,DURHAM,NH 03824. RP MAYEWSKI, PA (reprint author), UNIV NEW HAMPSHIRE,INST STUDY EARTH OCEANS & SPACE,GLACIER RES GRP,DURHAM,NH 03824, USA. NR 42 TC 100 Z9 106 U1 1 U2 7 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD JUL 20 PY 1993 VL 98 IS D7 BP 12839 EP 12847 DI 10.1029/93JD01085 PG 9 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA LP166 UT WOS:A1993LP16600021 ER PT J AU MORRIS, JT KELLY, JW AF MORRIS, JT KELLY, JW TI RIFABUTIN-INDUCED AGEUSIA SO ANNALS OF INTERNAL MEDICINE LA English DT Letter ID COMPLEX RP MORRIS, JT (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 6 Z9 6 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD JUL 15 PY 1993 VL 119 IS 2 BP 171 EP 172 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA LU902 UT WOS:A1993LU90200025 PM 8390142 ER PT J AU BARATTA, FI AF BARATTA, FI TI STABILITY REVISITED FOR A STRAIGHT-FRONTED EDGE CRACK IN A 3-POINT LOADED ROUND BEND BAR SO INTERNATIONAL JOURNAL OF FRACTURE LA English DT Article ID SPECIMENS RP BARATTA, FI (reprint author), USA,RES LAB,WATERTOWN,MA 02172, USA. NR 14 TC 2 Z9 2 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0376-9429 J9 INT J FRACTURE JI Int. J. Fract. PD JUL 15 PY 1993 VL 62 IS 2 BP R29 EP R35 DI 10.1007/BF00035164 PG 7 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA MB331 UT WOS:A1993MB33100008 ER PT J AU NICKOLAISEN, SL CARTLAND, HE AF NICKOLAISEN, SL CARTLAND, HE TI THE H+OCS HOT ATOM REACTION - CO STATE DISTRIBUTIONS AND TRANSLATIONAL ENERGY FROM TIME-RESOLVED INFRARED-ABSORPTION SPECTROSCOPY SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID CARBONYL SULFIDE; HYDROGEN-ATOMS; EXCITATION; OCS AB Time-resolved infrared diode laser spectroscopy has been used to probe CO internal and translational excitation from the reaction of hot H atoms with OCS. Product distributions should be strongly biased toward the maximum 1.4 eV collision energy obtained from 278 nm pulsed photolysis of HI. Rotations and vibrations are both colder than predicted by statistical density of states theory, as evidenced by large positive surprisal parameters. The bias against rotation is stronger than that against vibration, with measurable population as high as v = 4. The average CO internal excitation is 1920 cm-1, accounting for only 13 % of the available energy. Of the energy balance, time-resolved sub-Doppler line shape measurements show that more than 38% appears as relative translation of the separating CO and SH fragments. Studies of the relaxation kinetics indicate that some rotational energy transfer occurs on the time scale of our measurements, but the distributions do not relax sufficiently to alter our conclusions. Vibrational distributions are nascent, though vibrational relaxation of excited CO is unusually fast in the OCS bath, with rates approaching 3% of gas kinetic for nu = 1. At 9720 cm-1 above the activation barrier, energy partitioning is consistent with incomplete IVR in an HSCO intermediate, followed by repulsive release of a large fraction of the available energy into relative translation. C1 US MIL ACAD,PHOTON RES CTR,W POINT,NY 10996. NR 25 TC 5 Z9 5 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD JUL 15 PY 1993 VL 99 IS 2 BP 1145 EP 1158 DI 10.1063/1.465412 PG 14 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA LM894 UT WOS:A1993LM89400039 ER PT J AU ANDREAS, EL LANGE, MA ACKLEY, SF WADHAMS, P AF ANDREAS, EL LANGE, MA ACKLEY, SF WADHAMS, P TI ROUGHNESS OF WEDDELL SEA-ICE AND ESTIMATES OF THE AIR-ICE DRAG COEFFICIENT SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID THICKNESS DISTRIBUTION; WIND STRESS; FRAM STRAIT; OCEAN; ZONE; MOMENTUM; HEAT AB The roughness of a sheet of sea ice encodes its deformational history and determines its aerodynamic coupling with the overlying air and underlying water. Here we report snow surface, ice surface, and ice underside roughness computed from 47 surface elevation profiles collected during a transect of the Weddell Sea. The roughness for each surface, parameterized as the standard deviation of the surface elevation, segregates according to whether or not a floe has been deformed: deformed ice has greater roughness than undeformed ice. Regardless of deformational history, the underside roughness is almost always greater than the snow surface and ice surface roughnesses, which are nearly equal. Roughness spectra for all three surfaces and for both deformed and undeformed ice roll off roughly as k-1 when the wavenumber k is between 0.1 and 3 rad m-1. The snow surface and underside spectra roll off somewhat faster than k-1, and the ice surface spectra roll off somewhat slower than k-1. Both top and underside Arctic ice roughness spectra, on the other hand, have been reported to roll off faster than k-2. We speculate that the excess spectral intensity at high wavenumbers in the Antarctic ice surface spectra results from the small-scale roughness that the ice sheet had on consolidation. This excess high-wavenumber spectral intensity persists in the ice surface spectra of second-year ice. Evidently, once formed, the ice surface remains unchanged on the microscale until the entire ice sheet melts. With a remote measurement of roughness, we should be able to decide whether an ice floe is deformed or undeformed. Our spectral analysis hints that remote sensing may also be able to differentiate between first-year and second-year ice. From the snow surface spectra, we compute a roughness scale xi that parameterizes the air-ice momentum coupling and lets us estimate the neutral stability drag coefficient referenced to a height of 10 m, C(DN10). Typical C(DN10) values are 1.1-1.4 x 10(-3) over undeformed ice and 1.3-1.8 X 10(-3) over deformed ice. C1 UNIV LAPLAND,CTR ARTIC,SF-96101 ROVIANIEMI,FINLAND. UNIV CAMBRIDGE,SCOTT SOLAR RES INST,CAMBRIDGE CB2 1ER,ENGLAND. RP ANDREAS, EL (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 44 TC 37 Z9 39 U1 0 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD JUL 15 PY 1993 VL 98 IS C7 BP 12439 EP 12452 DI 10.1029/93JC00654 PG 14 WC Oceanography SC Oceanography GA LN310 UT WOS:A1993LN31000012 ER PT J AU STROSCIO, MA KIM, KW AF STROSCIO, MA KIM, KW TI PIEZOELECTRIC SCATTERING OF CARRIERS FROM CONFINED ACOUSTIC MODES IN CYLINDRICAL QUANTUM WIRES SO PHYSICAL REVIEW B LA English DT Note ID OPTICAL-PHONON INTERACTION; HETEROSTRUCTURES AB Confined acoustic modes are derived for a free-standing nanometer-scale cylindrical polar semiconductor quantum wire. The piezoelectric scattering Hamiltonian is calculated for the interaction of charge carriers with the lowest-order azimuthally symmetric torsional modes in such nanometer-scale quantum wires. C1 N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. RP STROSCIO, MA (reprint author), USA,RES OFF,POB 12211,RES TRIANGLE PK,NC 27709, USA. NR 13 TC 26 Z9 26 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD JUL 15 PY 1993 VL 48 IS 3 BP 1936 EP 1938 DI 10.1103/PhysRevB.48.1936 PG 3 WC Physics, Condensed Matter SC Physics GA LP050 UT WOS:A1993LP05000074 ER PT J AU RUDIN, S REINECKE, TL AF RUDIN, S REINECKE, TL TI PLASMONS LOCALIZED AT POINT CHARGES IN SEMICONDUCTOR QUANTUM-WELLS SO PHYSICAL REVIEW B LA English DT Article ID ELECTRON PHONON INTERACTION; COLLECTIVE EXCITATIONS; HETEROSTRUCTURES AB The plasmon excitations of inhomogeneous carrier gases in semiconductor quantum wells in the presence of charged impurities are investigated. The random phase approximation for the carrier gas yields an integral equation which expresses the condition that plasmons may be self-consistently localized in the vicinity of the impurity. The localized plasmon is a density wave trapped at the impurity site and exists in the electron (hole) gas only for negative (positive) impurity charge. Bound states of the intersubband plasmon are found for all densities of the carrier gas in a quantum well, a result which differs qualitatively from the bulk case. Numerical results for the binding energies are given for a range of parameters. C1 USN, RES LAB, WASHINGTON, DC 20375 USA. RP USA, RES LAB, FT MONMOUTH, NJ 07703 USA. NR 9 TC 5 Z9 5 U1 0 U2 0 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD JUL 15 PY 1993 VL 48 IS 4 BP 2223 EP 2235 DI 10.1103/PhysRevB.48.2223 PG 13 WC Physics, Condensed Matter SC Physics GA LP540 UT WOS:A1993LP54000024 ER PT J AU OELSCHLAEGER, TA GUERRY, P KOPECKO, DJ AF OELSCHLAEGER, TA GUERRY, P KOPECKO, DJ TI UNUSUAL MICROTUBULE-DEPENDENT ENDOCYTOSIS MECHANISMS TRIGGERED BY CAMPYLOBACTER-JEJUNI AND CITROBACTER-FREUNDII SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE COATED-PITS; CYTOSKELETON; ENDOSOME ACIDIFICATION; MICROFILAMENTS; PROTEIN SYNTHESIS ID RECEPTOR-MEDIATED ENDOCYTOSIS; INTESTINAL EPITHELIAL-CELLS; COATED PIT FORMATION; SHIGELLA-FLEXNERI; ESCHERICHIA-COLI; HELA-CELLS; INVASION; PENETRATION; SALMONELLA; INFECTION AB Bacterial invasion of six different human epithelial cell lines showed that some strains of the intestinal pathogen Campylobacter jejuni invaded intestinal cell lines at a level 10(2)-10(4) times higher than reported previously for other Campylobacter strains. Separately, urinary tract isolates of Citrobacter freundii triggered a high-efficiency invasion of bladder cells. Use of multiple inhibitors with known effects on eukaryotic cell structures/processes allowed us to define in these genetically distinct bacterial genera unusual bacterial invasion mechanisms that uniquely require microtubules but not microfilaments. Campylobacter jejuni strain 81-176 uptake into 407 intestinal cells and Citrobacter entry into T24 bladder cells was blocked by microtubule depolymerization and inhibitors of coated-pit formation but not by microfilament depolymerization. Inhibitors of endosome acidification had no significant impact on intracellular survival of Campylobacter jejuni or Citrobacter freundii, but monensin markedly reduced Citrobacter uptake. Epithelial cell invasion by both of these bacterial genera was dependent upon de novo bacterial protein synthesis but not upon de novo eukaryotic cell protein synthesis. In contrast to the T24 cell line-specific, strict microtubule-dependent uptake, Citrobacter entry into other cell lines was inhibited by both microtubule and microfilament-depolymerization, suggesting that these bacteria encode two separate pathways for uptake (i, microtubule-dependent; ii, microfilament-dependent) that are cell line-specific and are recognized perhaps depending on the presence and abundance of appropriate eukaryotic receptors. C1 USN,MED RES INST,ENTER DIS PROGRAM,BETHESDA,MD 20814. RP OELSCHLAEGER, TA (reprint author), WALTER REED ARMY INST RES,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307, USA. RI Oelschlaeger, Tobias/B-5624-2015 NR 30 TC 226 Z9 232 U1 0 U2 8 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUL 15 PY 1993 VL 90 IS 14 BP 6884 EP 6888 DI 10.1073/pnas.90.14.6884 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA LM681 UT WOS:A1993LM68100104 PM 8341714 ER PT J AU BEAUDRY, WT WAGNER, GW WARD, JR AF BEAUDRY, WT WAGNER, GW WARD, JR TI CHARACTERIZATION OF THE MOLECULAR-EXCHANGE PROCESS OBSERVED FOR DIMETHYL METHYLPHOSPHONATE ADSORBED ON A SORPTIVE REACTIVE RESIN MIXTURE BY P-31 MAGNETIZATION-TRANSFER AND 2-D EXCHANGE MAS NMR SO JOURNAL OF MOLECULAR CATALYSIS LA English DT Article DE DIMETHYL METHYLPHOSPHONATE; MOLECULAR EXCHANGE; ION-EXCHANGE RESIN; MAGIC-ANGLE SPINNING NMR; P-31 NMR; LETHAL AGENT DECONTAMINATION ID POLYMER BEADS AB The molecular exchange of dimethyl methylphosphonate (DMMP) between the reactive and sorptive components in a mixture of three macroreticular resins (a high surface area carbonaceous adsorbent and strong-base and strong-acid ion-exchange resins) is characterized by P-31 MAS NMR. Data from P-31 MAS magnetization-transfer NMR experiments performed on four samples possessing 2, 6, 9 and 14% DMMP are analyzed using a modified two-site exchange model which takes into account that only a fraction of DMMP molecules adsorbed on the carbonaceous adsorbent (site B) are able to exchange with those residing on the ion-exchange resins (site A) during the time scale of the experiment. The exchange lifetime determined in this manner for DMMP adsorbed on the carbonaceous adsorbent (k(B)-1) remains fairly constant at ca. 50 ms for the four samples. The exchange lifetime for DMMP residing on the ion-exchange resins (k(A)-1) is observed to increase for lower weight-percent loadings: 250 ms (14%), 330 ms (9%), 500 ms (6%) and 670 ms (2%). P-31 MAS 2-D exchange NMR experiments indicate an optimum mixing time (tau(m)) of 0.2-0.5 s for the 14% sample, which is consistent with the measured exchange lifetimes. C1 USA,CTR CHEM RES DEV & ENGN,RES DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. NR 18 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-5102 J9 J MOL CATAL PD JUL 14 PY 1993 VL 83 IS 1-2 BP 183 EP 195 DI 10.1016/0304-5102(93)87018-4 PG 13 WC Chemistry, Physical SC Chemistry GA LQ324 UT WOS:A1993LQ32400018 ER PT J AU MIELKE, SL TAWA, GJ TRUHLAR, DG SCHWENKE, DW AF MIELKE, SL TAWA, GJ TRUHLAR, DG SCHWENKE, DW TI ENERGY-TRANSFER THROUGH EXCIPLEX FUNNEL STATES SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Note ID COLLISION COMPLEX; SPECTROSCOPY; MOLECULES; SURFACES; DYNAMICS C1 UNIV MINNESOTA,INST SUPERCOMP,CHEM PHYS PROGRAM,DEPT CHEM,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. NASA,AMES RES CTR,MOFFETT FIELD,CA 94035. RI Mielke, Steven/B-7533-2008; schwenke, david/I-3564-2013; Truhlar, Donald/G-7076-2015 OI Mielke, Steven/0000-0002-1938-7503; Truhlar, Donald/0000-0002-7742-7294 NR 30 TC 35 Z9 35 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD JUL 14 PY 1993 VL 115 IS 14 BP 6436 EP 6437 DI 10.1021/ja00067a079 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA LT173 UT WOS:A1993LT17300079 ER PT J AU DOUGLAS, AA WAGER, JE MORTON, DC KOH, JB HOGH, CP AF DOUGLAS, AA WAGER, JE MORTON, DC KOH, JB HOGH, CP TI HOT-ELECTRON LUMINESCENCE IN ZNS ALTERNATING-CURRENT THIN-FILM ELECTROLUMINESCENT DEVICES SO APPLIED PHYSICS LETTERS LA English DT Article ID TRANSPORT; EMISSION AB Hot electron luminescence experiments are performed on ZnS alternating-current thin-film electroluminescent (ACTFEL) devices in order to determine the extent to which the electron distribution is heated. The luminescence spectrum is found to be broad and essentially featureless up to a high energy cutoff of approximately 3.7 eV, which is determined by optical absorption within the ZnS. This result indicates that under normal operating conditions in a ZnS ACTFEL device, a significant fraction of the electrons transported across the phosphor possess energies equal to or in excess of the ZnS band gap. C1 OREGON STATE UNIV,CTR ADV MAT RES,DEPT ELECT & COMP ENGN,CORVALLIS,OR 97331. USA,COMMAND LAB,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. VITRON INC,EATONTOWN,NJ 07724. NR 9 TC 6 Z9 7 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 12 PY 1993 VL 63 IS 2 BP 231 EP 233 DI 10.1063/1.110350 PG 3 WC Physics, Applied SC Physics GA LL831 UT WOS:A1993LL83100038 ER PT J AU VANDERGRACHT, J RHODES, WT AF VANDERGRACHT, J RHODES, WT TI PARTIALLY COHERENT PERIODIC STOP FILTERING FOR INSPECTION OF PERIODIC OBJECTS SO APPLIED OPTICS LA English DT Article AB A partially coherent system is introduced for defect inspection of periodic objects such as integrated circuit photomasks. An experimental investigation demonstrates that the new system is more robust in the presence of optical setup noise than the corresponding coherent spatial filtering system. The system illumination is provided by an array of mutually incoherent point sources that image onto a grid of opaque spots at the pupil plane. Nonperiodic defects are displayed at the image plane as bright structures against a dark background. C1 GEORGIA INST TECHNOL, CTR OPT SCI & ENGN, ATLANTA, GA 30332 USA. RP VANDERGRACHT, J (reprint author), USA, RES LAB, 2800 POWDER MILL RD, ADELPHI, MD 20783 USA. NR 16 TC 3 Z9 3 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 10 PY 1993 VL 32 IS 20 BP 3708 EP 3714 PG 7 WC Optics SC Optics GA LM078 UT WOS:A1993LM07800010 PM 20829999 ER PT J AU LEVIN, LI HOLLY, EA SEWARD, JP AF LEVIN, LI HOLLY, EA SEWARD, JP TI BLADDER-CANCER IN A 39-YEAR-OLD FEMALE PHARMACIST SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Letter ID HANDLING ANTINEOPLASTIC DRUGS; POLYVINYL-CHLORIDE GLOVES; ANTI-NEOPLASTIC DRUGS; NON-HODGKINS LYMPHOMA; CYTO-TOXIC DRUGS; CYTOSTATIC DRUGS; OCCUPATIONAL EXPOSURE; UNITED-STATES; NURSES; CYCLOPHOSPHAMIDE C1 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT EPIDEMIOL & BIOSTAT,SAN FRANCISCO,CA 94143. STANFORD UNIV,MED CTR,SCH MED,DEPT HLTH RES & POLICY,STANFORD,CA 94305. UNIV CALIF BERKELEY,SCH PUBL HLTH,PREVENT MED RESIDENCY PROGRAM,BERKELEY,CA 94720. RP LEVIN, LI (reprint author), WALTER REED ARMY INST RES,DEPT EPIDEMIOL,DIV PREVENT MED,SUITE 250,1 TAFT COURT,ROCKVILLE,MD 20850, USA. NR 41 TC 9 Z9 9 U1 0 U2 0 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD JUL 7 PY 1993 VL 85 IS 13 BP 1089 EP 1091 DI 10.1093/jnci/85.13.1089 PG 3 WC Oncology SC Oncology GA LK823 UT WOS:A1993LK82300020 PM 8515497 ER PT J AU MARINO, MT PEGGINS, JO BREWER, TG AF MARINO, MT PEGGINS, JO BREWER, TG TI HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF A CANDIDATE 8-AMINOQUINOLINE ANTIMALARIAL DRUG (WR-242511) USING OXIDATIVE ELECTROCHEMICAL DETECTION SO JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS LA English DT Note AB WR 242511 (or I) is a new compound of the 8-aminoquinoline class designed to replace primaquine for the treatment of malaria. In order to perform preclinical and clinical testing, an assay was needed to determine drug levels in plasma samples. A simple and reliable reversed-phase high-performance liquid chromatographic (HPLC) method for the measurement of I in plasma using oxidative electrochemical detection is described. A 250-mul plasma sample containing WR 256408 (or II) as intemal standard was extracted with tert.-butyl methyl ether-2-propanol. A 25-jul aliquot of the extractant was used for HPLC analysis. The mobile phase was 50:50 acetonitrile-sodium acetate (50 mM, pH 6) with 1 mM EDTA. Compounds I and II were separated within 10 min. The limit of detection for I was 10 ng/ml (plasma) with a recovery around 72%. The method was validated in a dog experiment where levels were followed for 48 h. The method is sensitive and robust and can be used for routine drug analysis during pharmacokinetic studies. RP MARINO, MT (reprint author), WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV INTERNAL MED 2,WASHINGTON,DC 20307, USA. NR 7 TC 3 Z9 3 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4347 J9 J CHROMATOGR-BIOMED JI J. Chromatogr.-Biomed. Appl. PD JUL 2 PY 1993 VL 616 IS 2 BP 338 EP 343 DI 10.1016/0378-4347(93)80405-S PG 6 WC Chemistry, Analytical SC Chemistry GA LM640 UT WOS:A1993LM64000023 PM 8376517 ER PT J AU ROSENBERG, YJ ZACK, PM WHITE, BD PAPERMASTER, SF ELKINS, WR EDDY, GA LEWIS, MG AF ROSENBERG, YJ ZACK, PM WHITE, BD PAPERMASTER, SF ELKINS, WR EDDY, GA LEWIS, MG TI DECLINE IN THE CD4+ LYMPHOCYTE POPULATION IN THE BLOOD OF SIV-INFECTED MACAQUES IS NOT REFLECTED IN LYMPH-NODES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; MORPHOLOGIC CHANGES; TYPE-1 INFECTION; SOOTY MANGABEYS; HIV INFECTION; AIDS; LYMPHADENOPATHY; REPLICATION; RESERVOIRS; DISEASE AB Although loss of CD4+ lymphocytes in peripheral blood is a standard criterion for evaluating the course of HIV disease, little is known about changes within lymphoid organs, which contain the bulk (>50%) of the body's lymphocytes. Because such studies are feasible only by using non-human primates, we have examined lymph nodes (LNs), spleen, and blood from monkeys infected with two isolates of simian immunodeficiency virus (SIV). During both the acute and chronic phases of these infections, characteristic reductions in the blood CD4+ cell levels are not reflected in LN, where the CD4+ pool remains within normal levels. However, when circulating CD4/CD8 ratios have consistently fallen to approximately 0.5, striking decreases in the percentage of CD4 cells (CD4%) and CD4/CD8 ratios in LN occur concomitantly with dramatic increases in viral antigen expression on follicular dendritic cells within LN germinal centers (GCs). The data suggest that loss from the total T cell pool in minimal until the final stages of SIV and HIV disease and that the immunological deterioration of LN is the event that precipitates the increased susceptibility to infections and progression to AIDS. C1 WALTER REED ARMY INST RES,ROCKVILLE,MD 20852. NIAID,BETHESDA,MD 20892. RP ROSENBERG, YJ (reprint author), HENRY M JACKSON FDN,1500 E GUDE DR,ROCKVILLE,MD 20850, USA. NR 36 TC 56 Z9 56 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD JUL PY 1993 VL 9 IS 7 BP 639 EP 646 DI 10.1089/aid.1993.9.639 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA LQ607 UT WOS:A1993LQ60700009 PM 8103665 ER PT J AU REID, T AF REID, T TI THROMBOSIS AND RECOMBINANT INTERFERON-ALPHA - REPLY SO AMERICAN JOURNAL OF MEDICINE LA English DT Letter ID GAMMA-INTERFERON; ENDOTHELIAL-CELLS; UPPER EXTREMITY; ISCHEMIA; NECROSIS; MEMBRANE; MICE RP REID, T (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD JUL PY 1993 VL 95 IS 1 BP 115 EP 116 DI 10.1016/0002-9343(93)90243-I PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA LN568 UT WOS:A1993LN56800019 ER PT J AU KANE, AG ROBLES, HA SMIRNIOTOPOULOS, JG HEIRONIMUS, JD FISH, MH AF KANE, AG ROBLES, HA SMIRNIOTOPOULOS, JG HEIRONIMUS, JD FISH, MH TI RADIOLOGIC-PATHOLOGICAL CORRELATION - DIFFUSE PONTINE ASTROCYTOMA SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article DE BRAIN STEM, NEOPLASMS; RADIOLOGIC-PATHOLOGICAL CORRELATIONS ID BRAIN-STEM GLIOMAS; TUMORS; DIAGNOSIS; CHILDREN; CHILDHOOD; LESIONS; BIOPSY C1 BROOKE ARMY MED CTR,DEPT NUCL MED,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. RP KANE, AG (reprint author), BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234, USA. RI Smirniotopoulos, James/D-3726-2011 NR 24 TC 5 Z9 5 U1 0 U2 0 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD JUL-AUG PY 1993 VL 14 IS 4 BP 941 EP 945 PG 5 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA LM070 UT WOS:A1993LM07000026 PM 8352167 ER PT J AU LETTERIE, GS MURRAY, JE SAMLASKA, CP AF LETTERIE, GS MURRAY, JE SAMLASKA, CP TI FAILURE OF PROSTAGLANDIN INDUCTION IN AN OBSTRUCTIVE MULLERIAN ABNORMALITY SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Note DE UTERINE ANOMALIES; FAILED INDUCTION; PROSTAGLANDIN AB Failure of prostaglandins E2 and F2alpha to induce labor for intrauterine fetal death is infrequent. The factors contributing to these failures remain unclear. We describe a case of failed induction with the use of a combination of vaginal prostaglandin E2 and systemic prostaglandin F2alpha in a 24-week intrauterine fetal death in association with a noncommunicating rudimentary uterine horn The implications of this mullerian abnormality for theories of parturition are discussed. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859. NR 4 TC 3 Z9 3 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JUL PY 1993 VL 169 IS 1 BP 207 EP 209 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA LN987 UT WOS:A1993LN98700047 PM 8333456 ER PT J AU WITTICH, AC MURRAY, JE AF WITTICH, AC MURRAY, JE TI INTRAVAGINAL FOREIGN-BODY OF LONG-DURATION - A CASE-REPORT SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Note DE INTRAVAGINAL FOREIGN BODY; VAGINAL FOREIGN BODY; REMOVAL OF FOREIGN BODY AB Foul-smelling, bloody vaginal discharge and pelvic pain may indicate the presence of an unknown intravaginal foreign body. A case of an adult who underwent numerous examinations and a previous laparotomy without location of the foreign body is presented. Radiologic diagnosis and surgical removal of the object is described. RP WITTICH, AC (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859, USA. NR 2 TC 13 Z9 13 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JUL PY 1993 VL 169 IS 1 BP 211 EP 212 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA LN987 UT WOS:A1993LN98700049 PM 8333458 ER PT J AU KNAPIK, J ZOLTICK, J ROTTNER, HC PHILLIPS, J BIELENDA, C JONES, B DREWS, F AF KNAPIK, J ZOLTICK, J ROTTNER, HC PHILLIPS, J BIELENDA, C JONES, B DREWS, F TI RELATIONSHIPS BETWEEN SELF-REPORTED PHYSICAL-ACTIVITY AND PHYSICAL-FITNESS IN ACTIVE MEN SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article AB We examined relationships between self-reported physical activity and physical fitness in a group of 202 male military officers, 36 to 51 years of age. Physical activity was estimated from the Minnesota Leisure Time Physical Activity Questionnaire and classified as heavy, moderate, or light depending on the intensity of individual activities. Directly measured components of physical fitness included aerobic capacity (treadmill walking peak VO2), body composition (densitometry), muscle strength (isokinetic mode), and flexibility (bend-and-reach test). Both total and heavy activity were significantly (P < .05) related to aerobic capacity, body fat, fat-free mass, upper body strength, and flexibility. Moderate and light activity were not related to the fitness measures. We divided subjects into quartiles of physical activity and corrected the fitness measures for age and cigarette smoking status. Subjects with more total and heavy activity had higher aerobic capacity and lower body fat; subjects with more heavy activity also had greater upper body strength. Again, moderate and low activity were not related to any fitness measure. These data indicate that heavy physical activity is related to various components of physical fitness even after correction for age and smoking status in a group of men who are healthy, generally very active, and fit. RP KNAPIK, J (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT MED,NATICK,MA 01760, USA. NR 0 TC 30 Z9 31 U1 1 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JUL-AUG PY 1993 VL 9 IS 4 BP 203 EP 208 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA LU229 UT WOS:A1993LU22900002 PM 8398219 ER PT J AU CONNOLLY, BM JENSON, AB PETERS, CJ GEYER, SJ BARTH, JF MCPHERSON, RA AF CONNOLLY, BM JENSON, AB PETERS, CJ GEYER, SJ BARTH, JF MCPHERSON, RA TI PATHOGENESIS OF PICHINDE VIRUS-INFECTION IN STRAIN-13 GUINEA-PIGS - AN IMMUNOCYTOCHEMICAL, VIROLOGICAL, AND CLINICAL-CHEMISTRY STUDY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID END-PRODUCT; SILVER INTENSIFICATION; PEROXIDASE REACTION; HEMORRHAGIC-FEVER; PATHOLOGY; HAMSTERS AB Pichinde virus has been adapted to produce lethal infection of Strain 13 guinea pigs. Viral replication and presence of viral antigen in frozen tissues stained by immunofluorescence has been previously described. Further investigation into the pathogenesis of this disease has been hampered by the lack of a light microscopic method for correlating histologic lesions and the presence of Pichinde viral antigens. For this purpose, we developed a sensitive immunocytochemical technique for staining Pichinde viral antigens in formalin-fixed, paraffin-embedded tissue. Enhancement of the immunocytochemical staining with nickel chloride markedly improved detection of viral antigens. We examined frozen and formalin-fixed tissues from Strain 13 guinea pigs for viral antigens by light microscopy and immunocytochemistry at various intervals after infection with Pichinde virus. Progressive involvement of different tissues correlated with organ injury measured by serum biochemical abnormalities. Pichinde viral antigen was first detected in splenic macrophages five days after infection and their subsequent destruction facilitated persistent viremia. The inability to clear virus led to multiple organ infection and vascular involvement. Ensuing infections involved particularly the liver, spleen, adrenal glands, lungs, and intestines. Gastroenteritis developed, with extensive involvement of the muscularis mucosa throughout the gastrointestinal tract. Water and food intake decreased rapidly after day 8, leading to marked weight loss. Fatty changes of the liver suggested metabolic derangement that was further exacerbated terminally by adrenal infection and pulmonary impairment. C1 CTR DIS CONTROL & PREVENT, SPECIAL PATHOGENS BRANCH, ATLANTA, GA USA. SCRIPPS RES INST, SCRIPPS IMMUNOL REFERENCE LAB, LA JOLLA, CA USA. USA, MED RES INST INFECT DIS, FREDERICK, MD 21701 USA. SCRIPPS CLIN & RES FDN, DEPT PATHOL, LA JOLLA, CA 92037 USA. RP CONNOLLY, BM (reprint author), GEORGETOWN UNIV, MED CTR, DEPT PATHOL, WASHINGTON, DC 20007 USA. OI Geyer, Stefan/0000-0003-1746-9019 NR 23 TC 30 Z9 30 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1993 VL 49 IS 1 BP 10 EP 24 PG 15 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LU313 UT WOS:A1993LU31300002 PM 8394659 ER PT J AU OGWANG, RA MWANGI, JK GITHURE, J WERE, JBO ROBERTS, CR MARTIN, SK AF OGWANG, RA MWANGI, JK GITHURE, J WERE, JBO ROBERTS, CR MARTIN, SK TI FACTORS AFFECTING EXFLAGELLATION OF IN-VITRO CULTIVATED PLASMODIUM-FALCIPARUM GAMETOCYTES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MALARIA PARASITES; INDUCTION; BERGHEI AB The environment of Plasmodium falciparum gametocytes changes when they make the transition from the vertebrate to the invertebrate host. Gametocytes of this species cultivated in vitro were used to evaluate the effect of serum, pH, pCO2 tension, bicarbonate ion, and temperature on gamete formation. Temperature was the only factor responsible for keeping P. falciparum gametocytes in the inactivated state. Mature gametocytes held at temperatures above 30-degrees-C remained quiescent in 10% serum, even at low ambient pCO2, tension, alkaline pH, and in the presence of 25 mM bicarbonate ion. When the temperature of the medium was allowed to drop below 30-degrees-C, gametocytes emerged from the red blood cells and microgametocytes consistently exflagellated at pH 7.4, even in the absence of bicarbonate ion. With regard to bicarbonate ion, exflagellation in P. falciparum is similar to P. berghei and different from P. gallinaceum gametocytes, which have an obligate requirement for bicarbonate ion. C1 KENYA GOVT MED RES CTR,BIOMED SCI RES CTR,NAIROBI,KENYA. WALTER REED ARMY INST RES,USAMRU,WASHINGTON,DC 20307. RP OGWANG, RA (reprint author), KENYA GOVT MED RES CTR,CLIN RES CTR,NAIROBI,KENYA. NR 8 TC 33 Z9 33 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1993 VL 49 IS 1 BP 25 EP 29 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LU313 UT WOS:A1993LU31300003 PM 8352388 ER PT J AU DE, D BHADURI, AP MILHOUS, WK AF DE, D BHADURI, AP MILHOUS, WK TI A NOVEL PYRROLIDONOALKANEAMINE (WR268954) THAT MODULATES CHLOROQUINE RESISTANCE OF PLASMODIUM-FALCIPARUM IN-VITRO SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MULTIDRUG-RESISTANCE; POTENTIATING ACTION; MALARIA; DRUGS; PHARMACOLOGY; TETRANDRINE; REVERSAL; EFFLUX; CELLS AB With the recent observations of efflux of chloroquine from Plasmodium falciparum and modulation of chloroquine resistance by calcium channel blockers, such as verapamil, a great deal of attention has been focused on the development of new modulators that can potentiate the efficacy of chloroquine. We report a new compound, WR268954, that has weak intrinsic antimalarial activity compared to chloroquine. In vitro, it increased the susceptibilities of chloroquine-resistant P. falciparum strains to chloroquine and quinine, but did not affect the chloroquine-susceptible strains. In the presence of 2,000 nM of WR268954, the 50% inhibitory concentration of chloroquine for drug-resistant P. falciparum decreased 90-fold in comparison with the control (chloroquine only). The same concentration of WR268954 increased the potentiation of chloroquine in resistant strains to a level approximately equivalent to that observed for the sensitive strain. This compound also potentiates the efficacy of quinine in drug-resistant parasites. However, WR268954 did not enhance the efficacy of mefloquine in the mefloquine-resistant parasites. In this report, the data show the synergistic effect of WR268954 on the antimalarial activity of chloroquine in drug-resistant strains of P. falciparum, but only an additive effect on drug-sensitive strains of parasites. Compound WR268954 belongs to a pyrrolidino alkane amine class whose in vitro chloroquine resistance modulator activity supports the basis for the synthesis of this class of compounds. C1 USA,MED RES UNIT,AMER CONSULATE,AA,APO,BR-34030 RIO JANEIRO,BRAZIL. CENT DRUG RES INST,LUCKNOW 226001,UTTAR PRADESH,INDIA. RP DE, D (reprint author), WALTER REED ARMY INST RES,DEPT PARASITOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 28 TC 8 Z9 8 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1993 VL 49 IS 1 BP 113 EP 120 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LU313 UT WOS:A1993LU31300015 PM 8352383 ER PT J AU CANFIELD, CJ MILHOUS, WK AGER, AL ROSSAN, RN SWEENEY, TR LEWIS, NJ JACOBUS, DP AF CANFIELD, CJ MILHOUS, WK AGER, AL ROSSAN, RN SWEENEY, TR LEWIS, NJ JACOBUS, DP TI PS-15 - A POTENT, ORALLY-ACTIVE ANTIMALARIAL FROM A NEW CLASS OF FOLIC-ACID ANTAGONISTS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PLASMODIUM-FALCIPARUM; INVITRO; RESISTANCE AB A new, orally-active inhibitor of dihydrofolic acid reductase (DHFR), PS- 1 5 (N-(3-(2,4,5-trichlorophenoxy)propyloxy)-N'-(1-methylethyl)-imidocarbonimidicdiamide hydrochloride), has significant activity against drug-resistant Plasmodium falciparum. It is not cross-resistant with other inhibitors of DHFR (e.g., pyrimethamine and cycloguanil). Although it bears similarities to proguanil, PS-15 represents a new antifolate class of drugs that we have named oxyguanils or hydroxylamine-derived biguanides. This compound displays intrinsic antimalarial activity and also is metabolized in vivo to WR99210, an extremely active triazine inhibitor of DHFR. When tested in vitro against drug-resistant clones of P. falciparum, PS-15 was more active than proguanil, and the putative metabolite, WR99210, was more active than the proguanil metabolite cycloguanil. The drug is also more active as well as less toxic than proguanil when administered orally to mice infected with P. berghei. When administered orally to Aotus monkeys infected with multidrug-resistant P. falciparum, PS-15 was more active than either proguanil or WR99210. In 1973, WR99210 underwent clinical trials for safety and tolerance in volunteers. The trials showed gastrointestinal intolerance and limited bioavailability; further development of the drug was abandoned. Because PS-15 has intrinsic antimalarial activity, is not cross-resistant with other DHFR inhibitors, and can be metabolized to WR99210 in vivo, oral administration of this new drug should circumvent the shortcomings and retain the advantages found with both proguanil and WR99210. C1 WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. GORGAS MEM LAB,PANAMA CITY,PANAMA. JACOBUS PHARMACEUT CO,PRINCETON,NJ. UNIV MIAMI,SCH MED,CTR TROP PARASIT DIS,MIAMI,FL 33152. RP CANFIELD, CJ (reprint author), PHARMACEUT SYST INC,GAITHERSBURG,MD, USA. NR 25 TC 94 Z9 97 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1993 VL 49 IS 1 BP 121 EP 126 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LU313 UT WOS:A1993LU31300016 PM 8352384 ER PT J AU UDOMSANGPETCH, R BROWN, AE SMITH, CD WEBSTER, HK AF UDOMSANGPETCH, R BROWN, AE SMITH, CD WEBSTER, HK TI PLASMODIUM-COATNEYI RING-INFECTED ERYTHROCYTE SURFACE-ANTIGENS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PF155 RESA; FALCIPARUM MALARIA; T-CELL; ANTIBODIES; SEQUENCES; CANDIDATE; RESIDENTS; IMMUNITY; VACCINE; SERA AB Plasmodium coatneyi produced ring-infected erythrocyte surface antigen (RESA) during infection of the rhesus monkey. This antigen was immunogenic and elicited an antibody response that was not persistent but was boosted by repeated infections in a manner similar to that seen in P. falciparum infections in humans. Preliminary data showed that the appearance and increasing titer of antibodies to P. coatneyi RESA-like antigen were associated with prolongation of intervals from inoculation to patency and with control of parasitemia. Studies using both immunofluorescence assay and Western blot analysis showed that P. coatneyi-immune rhesus serum cross-reacted with P. falciparum antigens, but P. falciparum immune human serum did not recognize P. coatneyi antigens in either assay. These results show that P. coatneyi expresses RESA-like antigen that elicits an antibody response similar to that observed for human antibody to P. falciparum RESA. However, antibodies to P. coatneyi did not cross-react with P. falciparum RESA in erythrocyte membrane immunofluorescence assay and dot immunoblot analysis, suggesting that different immunogenic epitopes are present on the two molecules. Our observations support the use of this primate model in RESA-based vaccine development. C1 ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,DEPT VETMED,BANGKOK,THAILAND. RP UDOMSANGPETCH, R (reprint author), MAHIDOL UNIV,FAC SCI,DEPT PATHOBIOL,BANGKOK 10700,THAILAND. NR 19 TC 4 Z9 4 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1993 VL 49 IS 1 BP 127 EP 134 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LU313 UT WOS:A1993LU31300017 PM 8352385 ER PT J AU MILLER, AC PAYNE, BS AF MILLER, AC PAYNE, BS TI QUALITATIVE VERSUS QUANTITATIVE SAMPLING TO EVALUATE POPULATION AND COMMUNITY CHARACTERISTICS AT A LARGE-RIVER MUSSEL BED SO AMERICAN MIDLAND NATURALIST LA English DT Article ID OHIO RIVER AB Quantitative and qualitative sampling methods were used to study community characteristics, density, recruitment rates and population demography of abundant species of freshwater mussels (Family: Unionidae), at Ohio River Miles 444.2-445.6 in July 1989 and September 1990. Mean unionid densities (+/-SD) based on 100, 0.25-sq m total substratum samples at four sites ranged from 4.4 +/- 6.8 to 52.4 +/- 13.9 individuals/sq m. Mean densities of Corbicula fluminea ranged from 66.8 +/- 67.7 to 1352.8 +/- 96.1 individuals/sq m. Shannon-Weaver species diversity log2.306 (2.32 to 2.50) and evenness (0.76 to 0.90) at these sites indicated an equitable distribution of species within the community. Individuals of two abundant species, Quadrula pustulosa pustulosa and Pleurobema cordatum, were represented by most size classes, indicating generally sustained recruitment with some annual variation. Both sampling methods provided similar estimates of community composition, species richness, diversity and evenness. A comparison of these results with those from a previous survey at this bed indicates no major changes in biotic conditions between 1984 and 1989-1990. RP USA, ENVIRONM LAB, ENGINEER WATERWAYS EXPT STN, VICKSBURG, MS 39180 USA. NR 29 TC 33 Z9 33 U1 4 U2 12 PU AMER MIDLAND NATURALIST PI NOTRE DAME PA UNIV NOTRE DAME, BOX 369, ROOM 295 GLSC, NOTRE DAME, IN 46556 USA SN 0003-0031 EI 1938-4238 J9 AM MIDL NAT JI Am. Midl. Nat. PD JUL PY 1993 VL 130 IS 1 BP 133 EP 145 DI 10.2307/2426282 PG 13 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA LQ360 UT WOS:A1993LQ36000013 ER PT J AU MONGAN, PD PETERSON, RE AF MONGAN, PD PETERSON, RE TI INTRAVENOUS ANESTHETIC ALTERATIONS ON THE SPINAL-SCIATIC EVOKED-RESPONSE IN SWINE SO ANESTHESIA AND ANALGESIA LA English DT Article ID TRANSCRANIAL ELECTRICAL-STIMULATION; NITROUS-OXIDE; CORD ISCHEMIA; POTENTIALS; SURGERY; ANIMALS; CORTEX AB Sciatic evoked responses (ScER) are used to monitor the integrity of the anterior spinal cord during spinal surgery. To evaluate the effects of intravenous anesthetics on the lumbar spinal evoked potential (SpEP) and ScER, 28 swine were anesthetized with halothane and an intravenous infusion of ketamine. After experimental preparation, anesthesia was maintained with ketamine, and the swine were divided into four equal groups (n = 7). The evoked responses were generated by delivering an electrical stimuli to the interspinous ligaments caudal to Tl and T2. The lumbar SpEP was recorded from the interspinous ligaments caudal to L2 and L3. The ScERs were recorded bilaterally from electrodes placed adjacent to the sciatic nerves. In Group 1 the effects of bolus dose administration of ketamine were evaluated. In Groups 2-4 anesthesia was maintained with ketamine by continuous infusion and the effects of fentanyl, sufentanil, and propofol on the L2 SpEP and ScER were evaluated. There was no significant change in either the amplitude or latency of the L2 SpEP with any anesthetic studied. Ketamine administered in bolus doses (2.5,5, and 10 mg/kg) did not alter the ScER. After bolus doses of fentanyl 10 mug/kg or sufentanil 1 mug/kg, there was a similar decrement in the amplitude of the ScER (P < 0.05) that recovered at 10 min without changes in latency. There were no changes in the ScER associated with infusion of fentanyl 1-5 pg.kg-1.h-1 or sufentanil 0.1-0.5 mug.kg-1.h-1. Propofol in bolus dose (0.5-2 mg/kg) administration induced significant (P < 0.05) changes in amplitude and latency at 2.5 min and those effects resolved within 20 min. After full recovery of the ScER to baseline, propofol infusion (2-12 mg.kg-1.min-1) caused a decrement in amplitude and increase in latency with almost complete abolition of the ScER at 12 mg.kg-1.min-1. The results suggest that the use of propofol or bolus administration of opioids may cause changes in the ScER that would complicate interpretation. RP MONGAN, PD (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,MED CORPS,FT SAM HOUSTON,TX 78234, USA. NR 19 TC 3 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD JUL PY 1993 VL 77 IS 1 BP 149 EP 154 PG 6 WC Anesthesiology SC Anesthesiology GA LL119 UT WOS:A1993LL11900029 PM 8317723 ER PT J AU KOO, B BECKER, LE CHUANG, S MERANTE, F ROBINSON, BH MACGREGOR, D TEIN, I HO, VB MCGREAL, DA WHERRETT, JR LOGAN, WJ AF KOO, B BECKER, LE CHUANG, S MERANTE, F ROBINSON, BH MACGREGOR, D TEIN, I HO, VB MCGREAL, DA WHERRETT, JR LOGAN, WJ TI MITOCHONDRIAL ENCEPHALOMYOPATHY, LACTIC-ACIDOSIS, STROKE-LIKE EPISODES (MELAS) - CLINICAL, RADIOLOGICAL, PATHOLOGICAL, AND GENETIC OBSERVATIONS SO ANNALS OF NEUROLOGY LA English DT Article ID RAGGED-RED FIBERS; MYOCLONIC EPILEPSY; TRANSFER RNALEU(UUR); MOLECULAR-GENETICS; REDUCTASE-ACTIVITY; BLOOD-VESSELS; MYOPATHY; ENCEPHALOPATHY; MUTATION; DEFICIENCY AB We reviewed 10 patients (5 males, 5 females) with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes. The age of symptom onset ranged from 3 months to 12 years. All had lactic acidosis, multiple stroke-like events with secondary neurological deficits, radiological changes of progressive brain infarction, and muscle biopsy showing ragged-red fibers. In patients with earlier onset of symptoms (<2 yr), involvement tended to be more diffuse, with failure to thrive and early onset of delayed development. Patients whose symptoms appeared later tended to have focal neurological deficits with migraine-like headache, and a rate of cognitive regression reflecting the rapidity of disease progression. Radiological changes included multiple areas of infarction with initial predilection for parietal occipital areas, progressing to generalized atrophy. Pathological findings in muscle biopsies included type 1 fiber predominance, ragged-red fibers, increased intermyofibrillar lipid deposition, and abnormal mitochondria. Four patients showed mitochondrial DNA tRNA mutation at position 3,243. No difference was noted in clinical, radiological, or pathological findings in patients with and without this mutation, suggesting that multiple sites of point mutation may give rise to mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes. C1 HOSP SICK CHILDREN,DIV NEUROL,555 UNIV AVE,TORONTO M5G 1X8,ONTARIO,CANADA. HOSP SICK CHILDREN,DIV NEUROPATHOL,TORONTO M5G 1X8,ONTARIO,CANADA. HOSP SICK CHILDREN,DIV NEURORADIOL,TORONTO M5G 1X8,ONTARIO,CANADA. TORONTO HOSP,WESTERN DIV,DIV NEUROL,TORONTO,ON,CANADA. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. HOSP SICK CHILDREN,DIV METAB & GENET,TORONTO M5G 1X8,ONTARIO,CANADA. NR 46 TC 77 Z9 81 U1 0 U2 2 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0364-5134 J9 ANN NEUROL JI Ann. Neurol. PD JUL PY 1993 VL 34 IS 1 BP 25 EP 32 DI 10.1002/ana.410340107 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA LK404 UT WOS:A1993LK40400005 PM 8517676 ER PT J AU DROST, AC BURLESON, DG CIOFFI, WG MASON, AD PRUITT, BA AF DROST, AC BURLESON, DG CIOFFI, WG MASON, AD PRUITT, BA TI PLASMA CYTOKINES AFTER THERMAL-INJURY AND THEIR RELATIONSHIP TO INFECTION SO ANNALS OF SURGERY LA English DT Article ID TUMOR-NECROSIS-FACTOR; SEPTIC SHOCK; INTERLEUKIN-1; ENDOTOXIN; DISEASE; SEPSIS; IL-6 AB Objective The relationship of plasma cytokine levels to infection, core temperature, and to one another in patients with thermal injury was examined. Summary Background Data The response to infection has been associated with cytokines such as interleukin 1beta (IL1beta), interleukin 6 (IL6), and tumor necrosis factor alpha (TNFalpha), and these cytokines have been studied in various inflammatory diseases. The authors previously reported that patients with thermal injury have elevated IL1beta and IL6 plasma levels and that these cytokines may play different roles in the response to thermal injury. Methods IL1beta, IL6, and TNFalpha were measured by enzyme-linked immunosorbent assay (ELISA) in serial samples of plasma from 27 patients. Results IL6 and TNFalpha levels were increased in severely infected patients as compared to patients who remained free of infection, and the IL6 level was higher in infected patients who died than those who survived. There was no apparent relationship between IL1beta levels and infection. IL6 and IL1beta were positively correlated with core temperature. The correlations between IL6 and IL1beta, between IL6 and TNFalpha, and between TNFalpha and IL1beta were significant. Conclusions These results suggest that IL6 and TNFalpha play a role in the response of burned patients to infection. RP DROST, AC (reprint author), USA,INST SURG RES,LIB BRANCH,FT SAM HOUSTON,TX 78234, USA. NR 15 TC 115 Z9 116 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD JUL PY 1993 VL 218 IS 1 BP 74 EP 78 DI 10.1097/00000658-199307000-00012 PG 5 WC Surgery SC Surgery GA LN058 UT WOS:A1993LN05800012 PM 8328832 ER PT J AU KNAPP, JS BACK, AF BABST, AF TAYLOR, D RICE, RJ AF KNAPP, JS BACK, AF BABST, AF TAYLOR, D RICE, RJ TI IN-VITRO SUSCEPTIBILITIES OF ISOLATES OF HAEMOPHILUS-DUCREYI FROM THAILAND AND THE UNITED-STATES TO CURRENTLY RECOMMENDED AND NEWER AGENTS FOR TREATMENT OF CHANCROID SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Note ID HEMOPHILUS-DUCREYI AB We determined the in vitro susceptibilities of 54 isolates of Haemophilus ducreyi from Thailand (29 isolates) and San Francisco (25 isolates) to penicillin G, tetracycline, amoxicillin-clavulanic acid, ceftriaxone, cefixime, erythromycin, azithromycin, ciprofloxacin, ofloxacin, and trimethoprim-sulfamethoxazole. Isolates were susceptible to less-than-or-equal-to 0.25 mug of ceftriaxone per ml, less-than-or-equal-to 0.5 mug of cefixime per ml, less-than-or-equal-to 0.125 mug of ciprofloxacin per ml, and less-than-or-equal-to 0.06 mug of ofloxacin per ml. Erythromycin was active against all isolates (MIC for 90% of isolates tested, 0.25 mug/ml), as was azithromycin (MIC, less-than-or-equal-to 0.06 mug/ml). In contrast, all but one isolate were resistant to greater-than-or-equal-to 8.0 mug of tetracycline per ml, 11.1% of the isolates were resistant to greater-than-or-equal-to 8.0 mug of amoxicillin-clavulanic acid per ml, and 40.9% of the isolates were resistant to trimethoprim-sulfamethoxazole (MIC, greater-than-or-equal-to 4/76 mug/ml). C1 DEPT PUBL HLTH,SAN FRANCISCO,CA 94102. WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307. RP KNAPP, JS (reprint author), CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV SEXUALLY TRANSMITTED DIS LAB RES,ATLANTA,GA 30333, USA. NR 16 TC 25 Z9 25 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 1993 VL 37 IS 7 BP 1552 EP 1555 PG 4 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA LL214 UT WOS:A1993LL21400032 PM 8363390 ER PT J AU STASHOWER, ME YEAGER, JK SMITH, KJ SKELTON, HG WAGNER, KF AF STASHOWER, ME YEAGER, JK SMITH, KJ SKELTON, HG WAGNER, KF TI CIMETIDINE AS THERAPY FOR TREATMENT-RESISTANT PSORIASIS IN A PATIENT WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME SO ARCHIVES OF DERMATOLOGY LA English DT Article ID EPIDERMAL LANGERHANS CELLS; HISTAMINE; CYCLOSPORIN; IMMUNE C1 USA,WALTER REED ARMY INST RES,WASHINGTON,DC 20310. USN,ARMED FORCES INST PATHOL,WASHINGTON,DC 20350. HENRY M JACKSON FDN,ROCKVILLE,MD. RP STASHOWER, ME (reprint author), USN,NATL NAVAL MED CTR,BETHESDA,MD 20814, USA. NR 24 TC 5 Z9 5 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JUL PY 1993 VL 129 IS 7 BP 848 EP 850 PG 3 WC Dermatology SC Dermatology GA LM091 UT WOS:A1993LM09100003 PM 8323304 ER PT J AU RUE, LW CIOFFI, WG MASON, AD MCMANUS, WF PRUITT, BA AF RUE, LW CIOFFI, WG MASON, AD MCMANUS, WF PRUITT, BA TI IMPROVED SURVIVAL OF BURNED PATIENTS WITH INHALATION INJURY SO ARCHIVES OF SURGERY LA English DT Article; Proceedings Paper CT 100TH SCIENTIFIC SESSION OF THE WESTERN SURGICAL ASSOC CY NOV 15-18, 1992 CL SAN ANTONIO, TX SP W SURG ASSOC ID MORTALITY; OSCILLATIONS; VENTILATION AB Objective: To study a cohort of patients treated at the same institution and to compare that patient population with that of a previous report documenting the comorbidity of inhalation injury and pneumonia. Specifically, we wanted to determine whether there had been an improvement in survival of patients suffering inhalation injury. Design: A retrospective review. Settings The US Army Institute of Surgical Research, Ft Sam Houston, Tex, a 40-bed burn intensive care referral unit. Subjects: One thousand two hundred fifty-six thermally injured patients treated between january 1985 and December 1990. Main Outcome Measure: A comparison of pneumonia frequency and ultimate survival of the current cohort of patients as compared with a previously generated stepwise logistic analysis predicting mortality on the basis of 1980 to 1984 patient data. Results: Of 1256 burned patients admitted between 1985 and 1990, there were 330 identified as having inhalation injury. These patients were older (35.0 vs 26.6 years) and had more extensive bums (41.1% vs 18.3%) and a higher mortality (29.4% vs 5.0%) than did the patients without inhalation injury. When compared with a mortality predictor generated from 1980 through 1984 patient data, patients in the most recent period had a lower mortality than predicted (29.4% vs 41.4%). Patients with less severe injury (positive xenon scan, negative results of bronchoscopy; n=85), although having a similar incidence of pneumonia (13.1% vs 19.5%) as the same group from 1980 through 1984, accounted for the most improvement in survival. The 3.6% mortality was significantly less than the predicted rate of 15.7%. Patients with positive results of bronchoscopy (n=245) also showed some improvement in outcome from that predicted (38.3% vs 50.2%) despite no change in the rate of pneumonia (46.9% vs 48.5%). Further improvement in survival was realized in those patients supported with high-frequency ventilation. Although their age (33.9 vs 36.3 years), burn size (46.0% vs 45.5%), and duration of intubation (16.8 vs 15.1 days) were similar to those of conventionally treated patients, mortality was significantly less than predicted (16.4% vs 40.9%) and less than that in patients treated with conventional ventilation (16.4% vs 42.7%). Conclusions: The improvement in survival of patients with inhalation injury represents the aggregate effects of the general improvement and outcome of all burned patients, the prevention of pneumonia by high-frequency ventilation, and the reduced mortality from the pneumonias that did occur. C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 21 TC 76 Z9 78 U1 1 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD JUL PY 1993 VL 128 IS 7 BP 772 EP 780 PG 9 WC Surgery SC Surgery GA LL482 UT WOS:A1993LL48200008 PM 8317959 ER PT J AU YAMAMOTO, Y HUGHSON, RL SUTTON, JR HOUSTON, CS CYMERMAN, A FALLEN, EL KAMATH, MV AF YAMAMOTO, Y HUGHSON, RL SUTTON, JR HOUSTON, CS CYMERMAN, A FALLEN, EL KAMATH, MV TI OPERATION-EVEREST .2. AN INDICATION OF DETERMINISTIC CHAOS IN HUMAN HEART-RATE-VARIABILITY AT SIMULATED EXTREME ALTITUDE SO BIOLOGICAL CYBERNETICS LA English DT Article ID TIME-SERIES; STRANGE ATTRACTORS; SURROGATE DATA; DIMENSION; SYSTEMS; INFORMATION; SLEEP AB It has been shown that fluctuation of human heartbeat intervals (heart rate variability, HRV) reflects variations in autonomic nervous system activity. We studied HRV at simulated altitudes of over 6000 m from Holter electrocardiograms recorded during the Operation Everest II study (Houston et al. 1987). Stationary, approximately 30-min segments of HRV data from six subjects at sea level and over 6000 m were supplied to (1) spectral analysis to evaluate sympathetic and parasympathetic nervous system (SNS, PNS) activity, (2) the analysis of Poincare section of the phase space trajectory reconstructed on a delayed coordinate system to evaluate whether there was fluctuation with deterministic dynamics, (3) the estimation of the correlation dimension to evaluate a static property of putative attractors, and (4) the analysis of nonlinear predictability of HRV time series which could reflect a dynamic property of the attractor. Unlike HRV at sea level, the recordings at over 6000 m showed a strong periodicity (period of about 20 s) with small cycle-to-cycle perturbation. When this perturbation was expressed on a Poincare section, it seemed to be likely that the perturbation itself obeyed a deterministic law. The correlation dimensions of these recordings showed low dimensional values (3.5 +/- 0.4, mean +/- SD), whereas those of the isospectral surrogates showed significantly (P <0.05) higher values (5.3 +/- 0.5) with embedding dimensions of 5.6 +/- 0.9. At over 6000 m, the correlation coefficients between the observed and the predicted time series with the prediction time of <4 beats were significantly (P <0.01) higher than those for the surrogate data, whereas there was no significant difference in the nonlinear predictability between the observed and the surrogate data at sea level. The results of the spectral analyses showed that, at over 6000 m, there was hardly any power >0.15 Hz in the HRV spectra possibly due to PNS withdrawal. Hence, these deterministic and/or chaotic dynamics might be mediated by variations in SNS activity at over 6000 m. C1 MCMASTER UNIV,DEPT MED,HAMILTON L8N 3Z5,ONTARIO,CANADA. UNIV VERMONT,BURLINGTON,VT 05401. UNIV WATERLOO,FAC APPL HLTH SCI,DEPT KINESIOL,WATERLOO N2L 3G1,ONTARIO,CANADA. UNIV SYDNEY,FAC HLTH SCI,DEPT BIOL SCI,LIDCOMBE,NSW 2141,AUSTRALIA. USA,ENVIRONM MED RES INST,NATICK,MA 01760. FU NHLBI NIH HHS [HL-17731, HL-14985] NR 36 TC 39 Z9 41 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-1200 J9 BIOL CYBERN JI Biol. Cybern. PD JUL PY 1993 VL 69 IS 3 BP 205 EP 212 DI 10.1007/BF00198960 PG 8 WC Computer Science, Cybernetics; Neurosciences SC Computer Science; Neurosciences & Neurology GA LP948 UT WOS:A1993LP94800003 PM 8373891 ER PT J AU YEE, E KOSTENIUK, PR CHANDLER, GM BILTOFT, CA BOWERS, JF AF YEE, E KOSTENIUK, PR CHANDLER, GM BILTOFT, CA BOWERS, JF TI STATISTICAL CHARACTERISTICS OF CONCENTRATION FLUCTUATIONS IN DISPERSING PLUMES IN THE ATMOSPHERIC SURFACE-LAYER SO BOUNDARY-LAYER METEOROLOGY LA English DT Article ID BOUNDARY-LAYER; STOCHASTIC-MODEL; HOMOGENEOUS TURBULENCE; SIMULATION AB Measurements have been made of concentration fluctuations in a dispersing plume from an elevated point source in the atmospheric surface layer using a recently developed fast-response photoionization detector. This detector, which has a frequency response (-6 dB point) of about 100 Hz, is shown to be capable of resolving the fluctuation variance contributed by the energetic subrange and most of the inertial-convective subrange, with a reduction in the fluctuation variance due to instrument smoothing of the finest scales present in the plume of at most 4%. Concentration time series have been analyzed to obtain the statistical characteristics of both the amplitude and temporal structure of the dispersing plume. We present alongwind and crosswind concentration fluctuation profiles of statistics of amplitude structure such as total and conditional fluctuation intensity, skewness and kurtosis, and of temporal structure such as intermittency factor, burst frequency, and mean burst persistence time. Comparisons of empirical concentration probability distributions with a number of model distributions show that our near-neutral data are best represented by the lognormal distribution at shorter ranges, where both plume meandering and fine-scale in-plume mixing are equally important (turbulent-convective regime), and by the gamma distribution at longer ranges, where internal structure or spottiness is becoming dominant (turbulent-diffusive regime). The gamma distribution provides the best model of the concentration pdf over all downwind fetches for data measured under stable stratification. A physical model is developed to explain the mechanism-induced probabilistic schemes in the alongwind development of a dispersing plume, that lead to the observed probability distributions of concentration. Probability distributions of concentration burst length and burst return period have been extracted and are shown to be modelled well with a power-law distribution. Power spectra of concentration fluctuations are presented. These spectra exhibit a significant inertial-convective subrange, with the frequency at the spectral peak decreasing with increasing downwind fetch. The Kolmogorov constant for the inertial-convective subrange has been determined from the measured spectra to be 0.17 +/- 0.03. C1 KOSTENIUK CONSULTING LTD,SASKATOON S7M 2L9,SK,CANADA. S&J ENGN INC,SCARBOROUGH M1V 3S1,ON,CANADA. USA,MAT TEST DIRECTORATE,DIV METEROL,DUGWAY PROVING GROUND,UT 84022. NR 28 TC 46 Z9 47 U1 0 U2 4 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0006-8314 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD JUL PY 1993 VL 65 IS 1-2 BP 69 EP 109 DI 10.1007/BF00708819 PG 41 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA LR178 UT WOS:A1993LR17800004 ER PT J AU TENERIELLO, MG EBINA, M LINNOILA, RI HENRY, M NASH, JD PARK, RC BIRRER, MJ AF TENERIELLO, MG EBINA, M LINNOILA, RI HENRY, M NASH, JD PARK, RC BIRRER, MJ TI P53 AND KI-RAS GENE-MUTATIONS IN EPITHELIAL OVARIAN NEOPLASMS SO CANCER RESEARCH LA English DT Article ID ONCOGENE; ADENOCARCINOMAS; AMPLIFICATION; ACTIVATION; CANCER; TUMORS AB In an effort to define the pathogenic relationship between ovarian neoplasms spanning the clinicopathological spectrum from benign to malignant, the incidence of Ki-ras and p53 mutations was determined in 20 ovarian cystadenomas, 20 low malignant potential (LMP) tumors of the ovary, and 23 ovarian carcinomas. Using DNA extracted from paraffin embedded tissue, polymerase chain reaction amplification, designed restriction fragment length polymorphism analysis, and DNA sequencing, 1 cystadenoma (5%), 6 LMP tumors (30%), and 1 ovarian carcinoma (4%) demonstrated an activated Ki-ras gene. All of the Ki-ras mutations identified except one were GGT to GAT transversions at codon 12. One LMP tumor demonstrated a CAA to CAC transversion at codon 61. Using polymerase chain reaction/single strand conformational polymorphism, DNA sequencing, and immunohistochemistry, 11 ovarian carcinomas (48%) demonstrated a p53 mutation. These mutations included 5 mis-sense. 2 nonsense, and 1 frameshift mutation located within exons 6-8 and 3 mutations that were identified only by immunohistochemical staining. No p53 mutations could be identified in cystadenomas or LMP tumors. Clinically, the presence of either a Ki-ras or p53 mutation was associated with advanced stage disease. The pattern of Ki-ras and p53 mutations appears to distinguish LMP tumors from invasive carcinomas and suggests that they may be separate biological entities. C1 NAT NAVAL MED CTR, DEPT OBSTET & GYNECOL GYNECOL ONCOL, BETHESDA, MD 20889 USA. WALTER REED ARMY MED CTR, DEPT OBSTET & GYNECOL GYNECOL ONCOL, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, DEPT PATHOL, BETHESDA, MD 20889 USA. NCI, DIV CANC PREVENT & CONTROL, BIOMARKERS & PREVENT RES BRANCH, ROCKVILLE, MD 20850 USA. NR 28 TC 220 Z9 223 U1 0 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JUL 1 PY 1993 VL 53 IS 13 BP 3103 EP 3108 PG 6 WC Oncology SC Oncology GA LL131 UT WOS:A1993LL13100032 PM 8319218 ER PT J AU COWAN, FM BROOMFIELD, CA AF COWAN, FM BROOMFIELD, CA TI PUTATIVE ROLES OF INFLAMMATION IN THE DERMATOPATHOLOGY OF SULFUR MUSTARD SO CELL BIOLOGY AND TOXICOLOGY LA English DT Article DE INFLAMMATION; PROTEASE; SULFUR MUSTARD ID INTERCELLULAR-ADHESION MOLECULE-1; SKIN MAST-CELLS; LEUKOCYTE ADHESION; DELAYED-HYPERSENSITIVITY; CUTANEOUS INFLAMMATION; CONTACT-DERMATITIS; BASEMENT-MEMBRANE; ATOPIC-DERMATITIS; PROTEASE ACTIVITY; EPITHELIAL-CELLS RP COWAN, FM (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,SGRD,UV,PB,ABERDEEN PROVING GROUND,MD 21010, USA. NR 67 TC 47 Z9 48 U1 1 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0742-2091 J9 CELL BIOL TOXICOL JI Cell Biol. Toxicol. PD JUL-SEP PY 1993 VL 9 IS 3 BP 201 EP 213 DI 10.1007/BF00755599 PG 13 WC Cell Biology; Toxicology SC Cell Biology; Toxicology GA MD543 UT WOS:A1993MD54300001 PM 8299000 ER PT J AU GROSS, CL INNACE, JK HOVATTER, RC MEIER, HL SMITH, WJ AF GROSS, CL INNACE, JK HOVATTER, RC MEIER, HL SMITH, WJ TI BIOCHEMICAL MANIPULATION OF INTRACELLULAR GLUTATHIONE LEVELS INFLUENCES CYTOTOXICITY TO ISOLATED HUMAN-LYMPHOCYTES BY SULFUR MUSTARD SO CELL BIOLOGY AND TOXICOLOGY LA English DT Article DE CYTOTOXICITY; GLUTATHIONE; LYMPHOCYTES; SULFUR MUSTARD ID BUTHIONINE SULFOXIMINE; PHENYLALANINE MUSTARD; DEPLETION; TOXICITY; CELLS; INHIBITION; CULTURE; SINGLE; MICE AB Glutathione (GSH) is the major nonprotein thiol that can protect cells from damage due to electrophilic alkylating agents by forming conjugates with the agent. Sulfur mustard (HD) is an electrophilic alkylating agent that has potent mutagenic, carcinogenic, cytotoxic, and vesicant properties. Compounds that elevate or reduce intraceIlular levels of GSH may produce changes in cytotoxicity induced by sulfur mustard. Pretreatment of human peripheral blood lymphocytes (PBL) for 72 hr with 1 mM buthionine sulfoximine (BSO), which reduces intracellular GSH content to approximately 26% of control, appears to sensitize these in vitro cells to the cytotoxic effects of 10 mu M HD but not to higher HD concentrations. Pretreatment of PBL for 48 hr with 10 mM N-acetyl cysteine (NAC), which elevates intracellular glutathione levels ro 122% of control, appears to partially protect these in vitro cells from the cytotoxic effects of 10 mu M HD but not to higher HD concentrations. Augmentation of intracellular levels of glutathione may provide partial protection against cytotoxicity of sulfur mustard. RP GROSS, CL (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,SGRD,UV,PB,ABERDEEN PROVING GROUND,MD 21010, USA. NR 27 TC 74 Z9 77 U1 0 U2 6 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0742-2091 J9 CELL BIOL TOXICOL JI Cell Biol. Toxicol. PD JUL-SEP PY 1993 VL 9 IS 3 BP 259 EP 267 DI 10.1007/BF00755604 PG 9 WC Cell Biology; Toxicology SC Cell Biology; Toxicology GA MD543 UT WOS:A1993MD54300006 PM 8299004 ER PT J AU COWAN, FM YOURICK, JJ HURST, CG BROOMFIELD, CA SMITH, WJ AF COWAN, FM YOURICK, JJ HURST, CG BROOMFIELD, CA SMITH, WJ TI SULFUR MUSTARD-INCREASED PROTEOLYSIS FOLLOWING IN-VITRO AND IN-VIVO EXPOSURES SO CELL BIOLOGY AND TOXICOLOGY LA English DT Article DE HAIRLESS GUINEA PIGS; LYMPHOCYTES; PROTEASE; SULFUR MUSTARD ID PROTEASE ACTIVITY; NIACINAMIDE AB The pathologic mechanisms underlying sulfur mustard (HD)-induced skin vesication are as yet undefined. Papirmeister et al. (1985) postulate enhanced proteolytic activity as a proximate cause of HD-induced cutaneous injury. Using a chromogenic peptide substrate assay, we previously reported that in vitro exposure of cell cultures to HD enhances proteolytic activity. We have continued our investigation of HD-increased proteolytic activity in vitro and have expanded our studies to include an in vivo animal model for HD exposure. In vitro exposure of human peripheral blood lymphocytes (PBL) to HD demonstrated that the increase in proteolytic activity is both time- and temperature-dependent. Using a panel of 10 protease substrates, we established that the HD-increased proteolysis was markedly different from thar generated by plasminogen activator. The hairless guinea pig is an animal model used for the study of HD-induced dermal pathology. When control and HD-exposed PBL and hairless guinea pig skin where examined, similarities in their protease substrate reactivities were observed. HD-exposed hairless guinea pig skin biopsies demonstrated increased proteolytic activity that was time-dependent. The HD-increased proteolytic response was similar in both in vitro and in vivo studies and may be useful for elucidating both the mechanism of HD-induced vesication and potential treatment compounds. C1 USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,SGRD,UV,PB,ABERDEEN PROVING GROUND,MD 21010. NR 16 TC 25 Z9 25 U1 0 U2 2 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0742-2091 J9 CELL BIOL TOXICOL JI Cell Biol. Toxicol. PD JUL-SEP PY 1993 VL 9 IS 3 BP 269 EP 277 DI 10.1007/BF00755605 PG 9 WC Cell Biology; Toxicology SC Cell Biology; Toxicology GA MD543 UT WOS:A1993MD54300007 PM 8299005 ER PT J AU SUNDBERG, RJ DALVIE, D CORDERO, J SABAT, M MUSALLAM, HA AF SUNDBERG, RJ DALVIE, D CORDERO, J SABAT, M MUSALLAM, HA TI CARBAMATES OF (HYDROXYPHENOXY)METHYL HETEROAROMATIC SALTS AS ACETYLCHOLINESTERASE INHIBITORS AND PROTECTIVE AGENTS AGAINST ORGANOPHOSPHORUS COMPOUNDS SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID SOMAN; BINDING; PYRIDOSTIGMINE; PRETREATMENT; PHYSOSTIGMINE; ATROPINE; PRIMATES; EFFICACY; RECEPTOR; ANIMALS AB A series of N,N-dimethylcarbamates of 2-[(2'-, 3'-, and 4'-hydroxyphenoxy)methyl] heteroaromatic salts has been prepared. Pyridine, imidazole, quinoline, benzimidazole, and imidazo[1,2-a]pyridine derivatives were included. Most of the compounds are inhibitors of electric eel acetylcholinesterase and also show prophylactic activity toward a 2LD50 dose of soman in mice. C1 WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. RP UNIV VIRGINIA, DEPT CHEM, CHARLOTTESVILLE, VA 22901 USA. NR 38 TC 7 Z9 7 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X EI 1520-5010 J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD JUL-AUG PY 1993 VL 6 IS 4 BP 500 EP 505 DI 10.1021/tx00034a017 PG 6 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA LM738 UT WOS:A1993LM73800017 PM 8374048 ER PT J AU SUNDBERG, RJ DALVIE, D CORDERO, J MUSALLAM, HA AF SUNDBERG, RJ DALVIE, D CORDERO, J MUSALLAM, HA TI CARBAMATE DERIVATIVES OF 2-ARYLIMIDAZO[1,2-A]PYRIDINIUM SALTS AS ACETYLCHOLINESTERASE INHIBITORS AND PROTECTIVE AGENTS AGAINST ORGANOPHOSPHORUS COMPOUNDS SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID PHYSOSTIGMINE; EFFICACY; RECEPTOR; MEMORY; SOMAN AB A series of 2-arylimidazo[1,2-a]pyridinium salts with (N,N-dimethylcarbamoyl)oxy or (N-methylcarbamoyl)oxy groups at the 3'- or 4'-position on the phenyl substituent and various substituents on the imidazo[1,2-a]pyridine ring have been synthesized. The compounds show in vitro inhibitory activity against electric eel acetylcholinesterase (AChE), type III, and several of the compounds show protective effects toward the organophosphorus AChE inhibitor soman in mice. The possible structural relationship of these compounds to physostigmine and pyridostigmine is considered. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP SUNDBERG, RJ (reprint author), UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901, USA. NR 19 TC 5 Z9 5 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0893-228X J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD JUL-AUG PY 1993 VL 6 IS 4 BP 506 EP 510 DI 10.1021/tx00034a018 PG 5 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA LM738 UT WOS:A1993LM73800018 PM 8374049 ER PT J AU LIPNICK, RN SFIKAKIS, PP KLIPPLE, GL TSOKOS, GC AF LIPNICK, RN SFIKAKIS, PP KLIPPLE, GL TSOKOS, GC TI ELEVATED SOLUBLE CD8 ANTIGEN AND SOLUBLE INTERLEUKIN-2 RECEPTORS IN THE SERA OF PATIENTS WITH JUVENILE RHEUMATOID-ARTHRITIS SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Article ID DISEASE-ACTIVITY; ACTIVATION; CELLS C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20010. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20010. RP LIPNICK, RN (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814, USA. NR 29 TC 14 Z9 14 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD JUL PY 1993 VL 68 IS 1 BP 64 EP 67 DI 10.1006/clin.1993.1096 PG 4 WC Immunology; Pathology SC Immunology; Pathology GA LJ158 UT WOS:A1993LJ15800010 PM 8513595 ER PT J AU SFIKAKIS, PP TESAR, J BARAF, H LIPNICK, R KLIPPLE, G TSOKOS, GC AF SFIKAKIS, PP TESAR, J BARAF, H LIPNICK, R KLIPPLE, G TSOKOS, GC TI CIRCULATING INTERCELLULAR-ADHESION MOLECULE-1 IN PATIENTS WITH SYSTEMIC-SCLEROSIS SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Article ID LUPUS-ERYTHEMATOSUS; SCLERODERMA; EXPRESSION; CLASSIFICATION; FIBROBLASTS; RECEPTORS; DISEASE C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20010. WALTER REED ARMY MED CTR,RHEUMATOL & CLIN IMMUNOL SERV,WASHINGTON,DC 20010. NR 24 TC 65 Z9 65 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD JUL PY 1993 VL 68 IS 1 BP 88 EP 92 DI 10.1006/clin.1993.1100 PG 5 WC Immunology; Pathology SC Immunology; Pathology GA LJ158 UT WOS:A1993LJ15800014 PM 8099861 ER PT J AU KEITH, J STOCKWELL, S BALL, D REMILLARD, K KAPLAN, D THANNHAUSER, T SHERWOOD, R AF KEITH, J STOCKWELL, S BALL, D REMILLARD, K KAPLAN, D THANNHAUSER, T SHERWOOD, R TI COMPARATIVE-ANALYSIS OF MACROMOLECULES IN MOLLUSK SHELLS SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY LA English DT Article ID ORGANIC MATRIX; LIQUID-CHROMATOGRAPHY; ACIDIC PROTEINS; CALCIUM-BINDING; SPICULE; BIOMINERALIZATION; CALMODULIN; COMPONENTS; CRYSTALS; MEMBRANE AB 1. Proteins and polysaccharides were isolated from the shells of molluscs; blue mussel, Mytilus edulis, chambered nautilus, Nautilus pompilius, and red abalone, Haliolus rufescens. 2- N-acetyl glucosamine was detected in nautilus but not mussel or abalone. 3. Amino acid analysis of protein fractions was completed for the three molluscs and purified proteins from the mussel were partially sequenced. 4. Calcium binding studies were carried out with some of the protein fractions. C1 USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. CORNELL UNIV,BIOTECHNOL CORE FACIL,ANALT & SYNTH FACIL,ITHACA,NY 14853. NR 59 TC 41 Z9 45 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0305-0491 J9 COMP BIOCHEM PHYS B JI Comp. Biochem. Physiol. B-Biochem. Mol. Biol. PD JUL-AUG PY 1993 VL 105 IS 3-4 BP 487 EP 496 DI 10.1016/0305-0491(93)90078-J PG 10 WC Biochemistry & Molecular Biology; Zoology SC Biochemistry & Molecular Biology; Zoology GA LK642 UT WOS:A1993LK64200008 PM 8365104 ER PT J AU TUNG, C MCALISTER, KW WANG, CM AF TUNG, C MCALISTER, KW WANG, CM TI UNSTEADY AERODYNAMIC BEHAVIOR OF AN AIRFOIL WITH AND WITHOUT A SLAT SO COMPUTERS & FLUIDS LA English DT Article AB Unsteady flow behavior and load characteristics of a 2-D VR-7 airfoil with and without a leading-edge slat were studied in the water tunnel of the Aeroflightdynamics Directorate, NASA Ames Research Center. Both airfoils were oscillated sinusoidally between 5-degrees and 25-degrees at Re = 200,000 to obtain the unsteady lift, drag and pitching moment data. A fluorescent dye was released from an orifice located at the leading edge of the airfoil for the purpose of visualizing the boundary layer and wake flow. The flow field and load predictions of an incompressible Navier-Stokes code based on a velocity-vorticity formulation were compared with the test data. The test and predictions both confirm that the slatted VR-7 airfoil delays both static and dynamic stall as compared to the VR-7 airfoil alone. C1 GEORGIA INST TECHNOL,SCH AEROSP ENGN,ATLANTA,GA 30332. RP TUNG, C (reprint author), NASA,AMES RES CTR,AVSCOM,US ARMY AEROFLIGHTDYNAM DIRECTORATE,MOFFETT FIELD,CA 94035, USA. NR 9 TC 5 Z9 5 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-7930 J9 COMPUT FLUIDS JI Comput. Fluids PD JUL-SEP PY 1993 VL 22 IS 4-5 BP 529 EP 547 DI 10.1016/0045-7930(93)90024-4 PG 19 WC Computer Science, Interdisciplinary Applications; Mechanics SC Computer Science; Mechanics GA LN724 UT WOS:A1993LN72400010 ER PT J AU MILLS, CB DIEHL, VA BIRKMIRE, DP MOU, LC AF MILLS, CB DIEHL, VA BIRKMIRE, DP MOU, LC TI PROCEDURAL TEXT - PREDICTIONS OF IMPORTANCE RATINGS AND RECALL BY MODELS OF READING-COMPREHENSION SO DISCOURSE PROCESSES LA English DT Article ID PROSE PASSAGES; CAUSAL; DIRECTIONS; EVENTS; UNITS AB Two models of text comprehension, a referential model proposed by Kintsch and van Dijk (1978) and a causal model proposed by Trabasso and SperrY (1985), were tested in two experiments with eight procedural texts. In Experiment 1, 24 female college students rated the importance of propositions, idea units, and sentences to the overall procedure described in the texts on a 7-point scale. In Experiment 2, 16 female college students recalled each of the eight texts immediately after reading it. Predictors derived from the models were used to predict the ratings and the recall in multiple regression analyses. The results showed that the amount of variance accounted for by the predictors varied from text to text. For the ratings, the causal model accounted for significantly more variance than the referential model. For the recall, the causal model generally accounted for more variance but the difference was not significant. For the referential model, level within the hierarchy accounted for the most variance and for the causal model, the causal chain variable accounted for the most variance. The models were not as powerful as in previous research with narrative texts, perhaps because these models do not take into account the cognitive representation involved in doing the task described by a procedural text. C1 WESTERN ILLINOIS UNIV,MACOMB,IL 61455. USA,RES LAB,WASHINGTON,DC 20310. UNIV MARYLAND,COLL PK,MD 20742. RP MILLS, CB (reprint author), GOUCHER COLL,DEPT PSYCHOL,TOWSON,MD 21204, USA. NR 35 TC 11 Z9 11 U1 0 U2 0 PU ABLEX PUBL CORP PI NORWOOD PA 355 CHESTNUT ST, NORWOOD, NJ 07648 SN 0163-853X J9 DISCOURSE PROCESS JI Discl. Process. PD JUL-SEP PY 1993 VL 16 IS 3 BP 279 EP 315 PG 37 WC Psychology, Educational; Psychology, Experimental SC Psychology GA MC511 UT WOS:A1993MC51100003 ER PT J AU COULOMBE, RA HUIE, JM SHARMA, RP HUGGINS, JW AF COULOMBE, RA HUIE, JM SHARMA, RP HUGGINS, JW TI PHARMACOKINETICS OF THE ANTIVIRAL AGENT CARBOCYCLIC 3-DEAZAADENOSINE SO DRUG METABOLISM AND DISPOSITION LA English DT Article ID S-ADENOSYLHOMOCYSTEINE HYDROLASE; TISSUE; 3'-DIDEOXYINOSINE; HOMOCYSTEINE; ANALOGS; RATS; MICE AB The pharmacokinetics of carbocyclic 3-deazaadenosine (Cc3Ado), a competitive inhibitor of S-adenosyl-L-homocysteine hydrolase and novel antiviral agent, was investigated in female BALB/c mice. Mice were dosed either orally or intravenously with a single dose of 10 mg/kg (10 muCi [H-3]Cc3Ado), and blood and tissue samples were taken at selected intervals for 24 hr. The plasma concentration vs. time data for Cc3Ado was best described by a two-compartment open model with first-order elimination. The apparent half-life was 23 and 38 min, for intravenously and orally administered Cc3Ado, respectively. Depending on route, tissue concentrations of Cc3Ado reached their maximum by 120 min, and concentrations of Cc3Ado were greatest in the liver, followed by the kidney, spleen, and stomach. By 24 hr, all tissues contained a similar amount of Cc3Ado. In the plasma, one major labeled metabolite was detected, which increased in concentration over time until about 45 min after dosing. None of the plasma Cc3Ado was protein bound, as assessed by in vitro protein binding analysis. Oral Cc3Ado was about 20% bioavailable. Data from this first investigation of the pharmacokinetics of Cc3Ado indicate that this antiviral agent is rapidly distributed and eliminated from the plasma and that distribution to tissues is wide-spread and rapid. C1 UTAH STATE UNIV,DEPT VET SCI,PROGRAMS TOXICOL & MOLEC BIOL,LOGAN,UT 84322. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RI Coulombe, Roger/G-7523-2012 NR 13 TC 5 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-9556 J9 DRUG METAB DISPOS JI Drug Metab. Dispos. PD JUL-AUG PY 1993 VL 21 IS 4 BP 555 EP 559 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA LP256 UT WOS:A1993LP25600001 PM 8104112 ER PT J AU KADAKIA, SC PARKER, A ANGUEIRA, C CASSADAY, M AF KADAKIA, SC PARKER, A ANGUEIRA, C CASSADAY, M TI FAILURE TO DEFLATE THE BALLOON OF REPLACEMENT GASTROSTOMY TUBES SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID DUODENAL OBSTRUCTION; BUTTON C1 BROOKE ARMY MED CTR,GASTROENTEROL SERV,SAN ANTONIO,TX. BROOKE ARMY MED CTR,DEPT MED,SAN ANTONIO,TX. NR 14 TC 5 Z9 5 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD JUL-AUG PY 1993 VL 39 IS 4 BP 576 EP 578 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA LQ571 UT WOS:A1993LQ57100025 PM 8365615 ER PT J AU GLASS, AR KIKENDALL, JW SOBIN, LH BOWEN, PE AF GLASS, AR KIKENDALL, JW SOBIN, LH BOWEN, PE TI SERUM 25-HYDROXYVITAMIN-D CONCENTRATIONS IN COLONIC NEOPLASIA SO HORMONE AND METABOLIC RESEARCH LA English DT Note ID VITAMIN-D; CALCIUM; CANCER C1 ARMED FORCES INST PATHOL,DIV GASTROINTESTINAL PATHOL,WASHINGTON,DC 20306. UNIV ILLINOIS,DEPT NUTR & MED DIETET,CHICAGO,IL 60680. RP GLASS, AR (reprint author), WALTER REED ARMY MED CTR,DEPT MED,ENDOCRINOL & GASTROENTEROL SERV,ENDOCRINOL SERV 7D,WASHINGTON,DC 20307, USA. NR 5 TC 9 Z9 9 U1 0 U2 0 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0018-5043 J9 HORM METAB RES JI Horm. Metab. Res. PD JUL PY 1993 VL 25 IS 7 BP 397 EP 398 DI 10.1055/s-2007-1002130 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA LQ321 UT WOS:A1993LQ32100016 PM 8406331 ER PT J AU ALEXANDER, L AF ALEXANDER, L TI STC TURNOUT SIGNALS INTEREST IN MILITARY SOFTWARE SO IEEE SOFTWARE LA English DT Editorial Material RP ALEXANDER, L (reprint author), USA,COMMUN ELECTR COMMAND,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 SN 0740-7459 J9 IEEE SOFTWARE JI IEEE Softw. PD JUL PY 1993 VL 10 IS 4 BP 109 EP 109 PG 1 WC Computer Science, Software Engineering SC Computer Science GA LK670 UT WOS:A1993LK67000025 ER PT J AU FILLER, RL VIG, JR AF FILLER, RL VIG, JR TI LONG-TERM AGING OF OSCILLATORS SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article AB A search performed in connection with a recent review of the literature on oscillator aging has revealed very few reports on the long term (e.g., for periods greater than 1 year) aging of oscillators. The purpose of this paper is to report aging results for more than 40 oscillators, from a variety of sources, for periods ranging from 1 year to more than 10 years. The aging data were accumulated with an automated aging facility. The oscillators that have been on test include temperature compensated crystal oscillators (TCXO's) and oven-controlled crystal oscillators (OCXO's). The TCXO's were maintained in a controlled temperature environment. Several of the TCXO'zs were built for a gun-launched sensor application and have been shown to be capable of surviving more than 30 000-g shock levels of 12 ms duration. The aging of these ruggedized TCXO's are surprisingly good (<2 x 10(-10)/d). The better OCXO's exhibit long term aging of a few parts in 10(12)/d. RP FILLER, RL (reprint author), USA,RES LAB,FREQUENCY CONTROL & TIMING BRANCH,FT MONMOUTH,NJ 07703, USA. NR 5 TC 13 Z9 13 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD JUL PY 1993 VL 40 IS 4 BP 387 EP 394 DI 10.1109/58.251287 PG 8 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA LR851 UT WOS:A1993LR85100015 PM 18263195 ER PT J AU CROSS, AS OPAL, SM SADOFF, JC GEMSKI, P AF CROSS, AS OPAL, SM SADOFF, JC GEMSKI, P TI CHOICE OF BACTERIA IN ANIMAL-MODELS OF SEPSIS SO INFECTION AND IMMUNITY LA English DT Review ID TUMOR-NECROSIS-FACTOR; CONTROLLED CLINICAL-TRIAL; GRAM-NEGATIVE BACTEREMIA; ESCHERICHIA-COLI; SEPTIC SHOCK; FACTOR-ALPHA; MONOCLONAL-ANTIBODY; PROTECTS MICE; MENINGOCOCCAL DISEASE; PRIMATE BACTEREMIA C1 WALTER REED ARMY INST RES,DEPT PATHOL,WASHINGTON,DC 20307. BROWN UNIV,SCH MED,DEPT MED,PROVIDENCE,RI 02860. RP CROSS, AS (reprint author), WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 76 TC 111 Z9 114 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUL PY 1993 VL 61 IS 7 BP 2741 EP 2747 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA LJ343 UT WOS:A1993LJ34300001 PM 8514375 ER PT J AU KANE, AG REDWINE, MD COSSI, AF AF KANE, AG REDWINE, MD COSSI, AF TI CHARACTERIZATION OF FOCAL FATTY CHANGE IN THE LIVER WITH A FAT-ENHANCED INVERSION-RECOVERY SEQUENCE SO JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING LA English DT Article DE LIVER, FATTY; LIVER; PULSE SEQUENCES; TISSUE CHARACTERIZATION; TISSUE SUPPRESSION AB A T1-weighted inversion-recovery (IR) sequence was used to study 15 patients with possible fatty change in the liver. The inversion time (TI) was calculated for optimal suppression of normal liver signal (t-null). Conventional spin-echo (SE) and short TI IR (STIR) sequences were also performed. For seven documented benign focal fatty liver lesions, the T1-weighted IR (fat-enhanced) sequence clearly enabled differentiation of normal from fat-infiltrated liver, whereas three of these lesions were isointense to normal liver with all other sequences. The livers of the other nine patients (two normal, one with diffuse fatty change, two with metastatic disease, one with hemangioma, one with focal nodular hyperplasia, one with simple cyst, and one with micronodular cirrhosis) showed homogeneous reduction of liver signal with the fat-enhanced IR sequence. RP KANE, AG (reprint author), BROOKE ARMY MED CTR,DEPT RADIOL,BLDG 1000,SAN ANTONIO,TX 78234, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU SOC MAGNETIC RESONANCE IMAGING PI EASTON PA 1991 NORTHAMPTON ST, EASTON, PA 18042-3189 SN 1053-1807 J9 JMRI-J MAGN RESON IM JI JMRI-J. Magn. Reson. Imaging PD JUL-AUG PY 1993 VL 3 IS 4 BP 581 EP 586 DI 10.1002/jmri.1880030406 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA LM781 UT WOS:A1993LM78100005 PM 8347950 ER PT J AU ROBINSON, SE RODRIGUEZ, ER SAMMONS, MT KEIM, J AF ROBINSON, SE RODRIGUEZ, ER SAMMONS, MT KEIM, J TI DOES BEING IN THE MILITARY AFFECT NURSES PERCEPTIONS OF WORK LIFE SO JOURNAL OF ADVANCED NURSING LA English DT Article ID JOB-SATISFACTION; BURNOUT; STRESS AB This study was a causal comparative investigation of military and civilian nurses' perceptions of selected aspects of work life. The Work Environment Scale, the Maslach Bumout Inventory and the Michigan Job Satisfaction Scale were administered to civilian and military samples matched on selected demographic variables. MANOVA procedures failed to reveal significant differences on measures of bumout and morale. Although military nurses were significantly more satisfied with issues of pay and fringe benefits, civilian nurses reported significantly greater job satisfaction, peer cohesion, supervisory support, decision making, autonomy, task orientation and opportunity to be innovative. These findings and suggested changes are discussed with attention to differences between the military and civilian work setting. C1 WALTER REED ARMY MED CTR,BALTIMORE,MD. RP ROBINSON, SE (reprint author), ARIZONA STATE UNIV,COUNSELLING PSYCHOL PROGRAMME,TEMPE,AZ 85287, USA. RI Dopko, Rae/J-7437-2015 NR 26 TC 5 Z9 5 U1 1 U2 4 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0309-2402 J9 J ADV NURS JI J. Adv. Nurs. PD JUL PY 1993 VL 18 IS 7 BP 1146 EP 1151 DI 10.1046/j.1365-2648.1993.18071146.x PG 6 WC Nursing SC Nursing GA LL712 UT WOS:A1993LL71200020 PM 8370907 ER PT J AU HAN, WY LU, Y LEE, HS COLE, MW CASAS, LM DEANNI, A JONES, KA YANG, LW AF HAN, WY LU, Y LEE, HS COLE, MW CASAS, LM DEANNI, A JONES, KA YANG, LW TI SHALLOW OHMIC CONTACT TO BOTH N-GAAS AND P-GAAS SO JOURNAL OF APPLIED PHYSICS LA English DT Note ID SOLID-PHASE EPITAXY; GE AB A shallow Pd/Ge/Ti/Pt/ohmic contact for both n- and p-GaAs has been investigated. The contacts were rapid thermally annealed in N2 for 15 s at temperatures from 350 to 550-degrees-C. The lowest average specific contact resistances were 4.7 X 10(-7) and 6.4 X 10(-7) OMEGA cm2 for the n- and p-GaAs, respectively, when the n-GaAs was doped with Si to 2 X 10(18) cm-3 and the p-GaAs was doped with carbon to 5 X 10(19) cm-3. Electrical measurements and Auger depth profiles showed that the contacts were stable as they remained ohmic after an anneal at 300-degrees-C for 20 h for both n- and p-GaAs. The p contact is more stable than the n contact at the higher temperatures where there is more As outdiffusion as determined by Auger depth profiles. Transmission electron microscopy showed that the interfaces between the p-GaAs and the contacts were smooth for both as-grown and annealed samples, and no oxides were detected. C1 USA,ELECTR TECHNOL & DEVICE LAB,FT MONMOUTH,NJ 07703. FORD MICROELECTR INC,COLORADO SPRINGS,CO 80921. RP HAN, WY (reprint author), RUTGERS UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855, USA. NR 14 TC 38 Z9 38 U1 0 U2 6 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 1 PY 1993 VL 74 IS 1 BP 754 EP 756 DI 10.1063/1.355248 PG 3 WC Physics, Applied SC Physics GA LK469 UT WOS:A1993LK46900119 ER PT J AU YOUNG, AJ SAWKA, MN QUIGLEY, MD CADARETTE, BS NEUFER, PD DENNIS, RC VALERI, CR AF YOUNG, AJ SAWKA, MN QUIGLEY, MD CADARETTE, BS NEUFER, PD DENNIS, RC VALERI, CR TI ROLE OF THERMAL FACTORS ON AEROBIC CAPACITY IMPROVEMENTS WITH ENDURANCE TRAINING SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE AEROBIC EXERCISE ADAPTATIONS; PHYSICAL FITNESS; BODY TEMPERATURE REGULATION; MAXIMAL OXYGEN UPTAKE; ERYTHROCYTE VOLUME; CITRATE SYNTHASE ID BLOOD-VOLUME; EXERCISE; WATER; MEN; PLASMA AB This investigation studied the importance of the rise in body temperature during exercise for aerobic capacity adaptations produced by endurance training. The approach used was to compare training effects produced by subjects exercising in hot (35-degrees-C) water vs. cold (20-degrees-C) water. Hot water was used to potentiate, and cold water to blunt, the rise in body temperature during exercise. Eighteen young men trained by cycle-ergometer exercise at 60% of maximal oxygen uptake (VO2max) while immersed to the neck in either hot (HWT, n = 9) or cold (CWT, n = 9) water for 60 min, 5 days/wk, for 8 wk. Before and after training, Vo2max, erythrocyte volume, plasma volume, and vastus lateralis citrate synthase activity were measured. Training increased (P < 0.01) Vo2max by 13%, with no difference between HWT and CWT in the magnitude of the effect. Erythrocyte volume increased 4% (P < 0.01) with training, with no difference between HWT and CWT in the magnitude of the effect. Plasma volume remained unchanged by training in both the HWT and CWT groups. Last, vastus lateralis citrate synthase activity increased by 38% with training, but there was no difference between HWT and CWT in the training effect. Thus, exercise-induced body temperature elevations are not an important stimulus for the aerobic adaptations to moderate-intensity endurance training. C1 BOSTON UNIV,MED CTR,USN,BLOOD RES LAB,BOSTON,MA 02118. RP YOUNG, AJ (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760, USA. NR 27 TC 14 Z9 14 U1 1 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 1993 VL 75 IS 1 BP 49 EP 54 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA LN649 UT WOS:A1993LN64900007 PM 8376300 ER PT J AU GUPTA, RK KORTE, DW REDDY, G AF GUPTA, RK KORTE, DW REDDY, G TI MUTAGENIC POTENTIAL OF NITROGUANIDINE AND NITROSOGUANIDINE IN THE DROSOPHILA-MELANOGASTER SEX-LINKED RECESSIVE LETHAL ASSAY SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE DROSOPHILA; SEX-LINKED RECESSIVE LETHAL ASSAY; NITROGUANIDINE; NITROSOGUANIDINE; MUTAGENIC POTENTIAL; PROPELLANT ID CHROMOSOME AB Nitroguanidine (NG) and its degradation product nitrosoguanidine (NSG) were evaluated for their mutagenic potential by using Drosophila melanogaster sex-linked recessive lethal (SLRL) assay. Following 72 h of feeding exposure, NG and NSG at concentrations of 4-8 mug ml-1 and 15-20 mg ml-1, respectively, were not mutagenic in the test system. The frequencies of mutations for NG and the negative control were 0.188% and 0.096%, respectively. The frequencies of mutations for NSG and the negative control experiments were 0.049% and 0.05%, respectively. The positive control mutation frequencies were 15% and 17.8% for the two assays. The differences between the mutation frequencies of NG and NSG and their negative controls were not significant. C1 USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. RP GUPTA, RK (reprint author), LETTERMAN ARMY INST RES,SAN FRANCISCO,CA 94129, USA. NR 16 TC 2 Z9 2 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD JUL-AUG PY 1993 VL 13 IS 4 BP 231 EP 234 DI 10.1002/jat.2550130404 PG 4 WC Toxicology SC Toxicology GA LP823 UT WOS:A1993LP82300002 PM 8376722 ER PT J AU SALEM, H AF SALEM, H TI SILVER,SEYMOUR,D. - OBITUARY SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Item About an Individual RP SALEM, H (reprint author), USA,CTR CHEM RES DEV & ENGN,SMCCR RST,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD JUL-AUG PY 1993 VL 13 IS 4 BP R3 EP R3 DI 10.1002/jat.2550130403 PG 1 WC Toxicology SC Toxicology GA LP823 UT WOS:A1993LP82300001 ER PT J AU LEMIRE, GW MCQUAID, MJ KOTLAR, AJ SAUSA, RC AF LEMIRE, GW MCQUAID, MJ KOTLAR, AJ SAUSA, RC TI INVESTIGATION OF THE GAS-PHASE (B)OVER-TILDE-(X) OVER-TILDE ELECTRONIC-SPECTRA OF CH-AR BY LASER-INDUCED FLUORESCENCE SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID MULTIPHOTON IONIZATION SPECTROSCOPY; POTENTIAL-ENERGY SURFACES; VANDERWAALS MOLECULES; OH-AR; VIBRATIONAL PREDISSOCIATION; ROTATIONAL SPECTRA; DIATOMIC MOLECULE; COMPLEXES; STATE; NO AB Gas-phase methyidyne-argon (CH-Ar) van der Waals complexes have been detected spectroscopically by laser-induced fluorescence (LIF) in the region of the CH B2SIGMA--X2PI(r) (0,0) and (1,0) bands near 363.5 and 388.9 nm, respectively. They are formed by a supersonic free-jet expansion of argon gas seeded with CH radicals generated from the 248 nm photolysis of CHBr2Cl. The excitation spectra reveal a number of rovibronic bands which are assigned to various stretching and/or bending motions of the CH-Ar complex. From the excitation spectra, lower limits for the ground and exited state binding energies are estimated. Rotational analysis based on combination differences and computer simulations of eight of the rovibronic bands yields an average ground state value of B(av)'' = 0. 174 +/- 0.004 cm-1 and excited state constants ranging from B' = 0.086-0.116 cm-1. This indicates that the CH-Ar van der Waals bond is lengthened considerably upon electronic excitation. A splitting of the ground state rotational energy levels, related to the anisotropy of the intermolecular potential and Coriolis coupling, is also observed. Based on an analysis of the rovibronic structure of the CH-Ar bands in terms of a hindered internal rotational model describing the interaction of Ar(1S0) atom with a CH monomer, a linear equilibrium geometry is inferred for the excited state and a ''T'' shaped geometry for the ground state. These results are compared to those obtained from gas-phase LIF studies of OH-Ar complexes recorded near the OH A2SIGMA+-X2PI(i) (0,0) and (1,0) bands. C1 USA, RES LAB, AMSRL, WT PC, ABERDEEN PROVING GROUND, MD 21005 USA. NR 46 TC 29 Z9 29 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD JUL 1 PY 1993 VL 99 IS 1 BP 91 EP 98 DI 10.1063/1.465708 PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA LJ308 UT WOS:A1993LJ30800011 ER PT J AU FRANCIS, TB SMALLRIDGE, RC KANE, J MAGNER, JA AF FRANCIS, TB SMALLRIDGE, RC KANE, J MAGNER, JA TI OCTREOTIDE CHANGES SERUM THYROTROPIN (TSH) GLYCOISOMER DISTRIBUTION AS ASSESSED BY LECTIN CHROMATOGRAPHY IN A TSH MACROADENOMA PATIENT SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID ASPARAGINE-LINKED OLIGOSACCHARIDES; SECRETING PITUITARY-ADENOMAS; MOUSE THYROTROPIN; GLYCOPROTEIN HORMONES; GLYCOSYLATION; CARBOHYDRATE; SIALYLATION; BIOACTIVITY; SUBUNIT; BIOSYNTHESIS AB A 28-yr-old woman with hyperthyroidism due to a TSH/GH-secreting macroadenoma was treated preoperatively with octreotide to attain euthyroidal status. Lectin chromatography, performed on her immunopurified serum TSH obtained at baseline and 1 week after 50 mug three times daily octreotide therapy, revealed a significant increase in ricin binding after octreotide. This result is consistent with increased amounts of TSH isoforms with more exposed galactose residues. Further clinical studies to elucidate the effects of pharmacological agents on serum TSH isoforms and TSH bioactivity are needed. C1 WALTER REED ARMY INST RES, DIV MED, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, ENDOCRINE METAB SERV, WASHINGTON, DC 20307 USA. UNIV ILLINOIS, HUMANA HOSP MICHAEL REESE, DIV ENDOCRINOL, CHICAGO, IL 60616 USA. NR 25 TC 15 Z9 15 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X EI 1945-7197 J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD JUL PY 1993 VL 77 IS 1 BP 183 EP 187 DI 10.1210/jc.77.1.183 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA LL828 UT WOS:A1993LL82800037 PM 8325941 ER PT J AU GEISBERT, TW JAHRLING, PB EZZELL, JW AF GEISBERT, TW JAHRLING, PB EZZELL, JW TI USE OF IMMUNOELECTRON MICROSCOPY TO DEMONSTRATE FRANCISELLA-TULARENSIS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note ID ANTIBODIES; DIAGNOSIS; TULAREMIA; IDENTIFICATION; DISEASE AB Three immunoelectron microscopy (IEM) methods were employed to show laboratory-cultivated Francisella tularensis. By the IEM assays, F. tularensis was distinguished from four antigenically distinct gram-negative bacteria. IEM should be a valuable tool for confirming presumptive isolates of F. tularensis and may potentially be useful for demonstrating other medically important bacteria. C1 USA,MED RES INST INFECT DIS,DIV BACTERIOL,FREDERICK,MD 21702. RP GEISBERT, TW (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,FREDERICK,MD 21702, USA. NR 14 TC 7 Z9 7 U1 2 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUL PY 1993 VL 31 IS 7 BP 1936 EP 1939 PG 4 WC Microbiology SC Microbiology GA LJ201 UT WOS:A1993LJ20100053 PM 8349780 ER PT J AU MONGAN, PD PETERSON, RE CULLING, RD AF MONGAN, PD PETERSON, RE CULLING, RD TI RIGHT HEART, RIGHT PRINCIPLE, WRONG CATHETER - REPLY SO JOURNAL OF CLINICAL MONITORING LA English DT Letter RP MONGAN, PD (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0748-1977 J9 J CLIN MONITOR JI J. Clin. Monit. PD JUL PY 1993 VL 9 IS 3 BP 208 EP 208 PG 1 WC Anesthesiology SC Anesthesiology GA LN092 UT WOS:A1993LN09200011 ER PT J AU ANTMAN, K CROWLEY, J BALCERZAK, SP RIVKIN, SE WEISS, GR ELIAS, A NATALE, RB COOPER, RM BARLOGIE, B TRUMP, DL DOROSHOW, JH AISNER, J PUGH, RP WEISS, RB COOPER, BA CLAMOND, GH BAKER, LH AF ANTMAN, K CROWLEY, J BALCERZAK, SP RIVKIN, SE WEISS, GR ELIAS, A NATALE, RB COOPER, RM BARLOGIE, B TRUMP, DL DOROSHOW, JH AISNER, J PUGH, RP WEISS, RB COOPER, BA CLAMOND, GH BAKER, LH TI AN INTERGROUP PHASE-III RANDOMIZED STUDY OF DOXORUBICIN AND DACARBAZINE WITH OR WITHOUT IFOSFAMIDE AND MESNA IN ADVANCED SOFT-TISSUE AND BONE SARCOMAS SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID HIGH-DOSE IFOSFAMIDE; ONCOLOGY-GROUP; COMBINATION CHEMOTHERAPY; ADRIAMYCIN NSC-123127; UNRESECTABLE SARCOMA; PULMONARY METASTASES; HUMAN NEOPLASIA; ACTINOMYCIN-D; TRIAL; CYCLOPHOSPHAMIDE C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. OHIO STATE UNIV,CTR HLTH,COLUMBUS,OH 43210. MCGILL UNIV,CTR CHEMOTHERAPY,MONTREAL H3A 2T5,QUEBEC,CANADA. PUGET SOUND ONCOL CONSORTIUM,SEATTLE,WA. CITY HOPE NATL MED CTR,DUARTE,CA 91010. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. UNIV MICHIGAN,MED CTR,ANN ARBOR,MI 48109. UNIV MARYLAND,CTR CANC,BALTIMORE,MD 21201. WAKE FOREST UNIV,BOWMAN GRAY SCH MED,WINSTON SALEM,NC 27103. UNIV ARKANSAS MED SCI HOSP,LITTLE ROCK,AR 72205. DUKE UNIV,DURHAM,NC 27706. ALLEGHENEY HLTH EDUC & RES,PITTSBURGH,PA. WAYNE STATE UNIV,MED CTR,DETROIT,MI 48202. SW ONCOL GRP,CTR STAT,SEATTLE,PA. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. UNIV IOWA,IOWA CITY,IA 52242. FU NCI NIH HHS [CA-14028, CA-04920, CA-37429] NR 47 TC 280 Z9 290 U1 0 U2 8 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD JUL PY 1993 VL 11 IS 7 BP 1276 EP 1285 PG 10 WC Oncology SC Oncology GA LL233 UT WOS:A1993LL23300012 PM 8315425 ER PT J AU NAGY, EV BURCH, HB LUKES, YG CARR, FE KOSUGI, S KOHN, LD BURMAN, KD AF NAGY, EV BURCH, HB LUKES, YG CARR, FE KOSUGI, S KOHN, LD BURMAN, KD TI IMMUNOGENICITY OF A UNIQUE REGION OF THE HUMAN THYROTROPIN RECEPTOR SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION LA English DT Article DE TSH RECEPTOR; ANTIBODIES; PEPTIDE ID AUTOIMMUNE THYROID-DISEASE; FAT-CELL MEMBRANES; GRAVES-DISEASE; MOLECULAR-CLONING; RABBIT ANTIBODIES; TSH RECEPTOR; EXPRESSION; BINDING; IDENTIFICATION; PROTEIN AB Clarifying the role of the TSH receptor protein in the autoimmune process may be the key to understanding the development of Graves' disease. In the present study we used a 16 amino acid peptide of the human TSH receptor (hTSHR) to immunize rabbits. A comparable, but theoretically less immunogenic, peptide was injected into other rabbits. The antibody response against these and other peptides, as well as against solubilized human thyroid membrane (TM) and guinea pig fat cell membrane (GPF) proteins, was tested using ELISA and Western blots. The GPF and TM binding pattern of rabbits' sera was compared to that of Graves' patients' sera. We have identified an area of antigenic cross-reactivity between GPF and TM; a 63 kD protein was present in both GPF and TM, and this protein uniformly bound IgG-s of the rabbits' postimmunization sera and one of eight Graves' patient's serum. We have shown that i) a theoretically immunogenic 16 amino acid peptide was indeed highly immunogenic in rabbits, ii) antibodies binding to GPF and TM were detected after immunization, and iii) the peak of thyroid stimulating immunoglobulin activity of sera was followed by a transient elevation of serum triiodothyronine levels. Further studies investigating the immunogenic epitopes of the hTSHR as well as characterizing the 63 kD protein are indicated. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,KYLE METAB UNIT,ENDOCRINE METAB SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. NIDDKD,BIOCHEM & METAB LAB,CELL REGULAT SECT,BETHESDA,MD. FU FIC NIH HHS [1 F05 TW04412-01] NR 34 TC 11 Z9 11 U1 0 U2 0 PU EDITRICE KURTIS S R L PI MILANO PA VIA LUIGI ZOJA, 30-20153 MILANO, ITALY SN 0391-4097 J9 J ENDOCRINOL INVEST JI J. Endocrinol. Invest. PD JUL-AUG PY 1993 VL 16 IS 7 BP 485 EP 493 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA LQ748 UT WOS:A1993LQ74800003 PM 7901266 ER PT J AU LEVER, JH RZENTKOWSKI, G AF LEVER, JH RZENTKOWSKI, G TI DEPENDENCE OF POST-STABLE FLUIDELASTIC BEHAVIOR ON THE DEGREES OF FREEDOM OF A TUBE BUNDLE SO JOURNAL OF FLUIDS AND STRUCTURES LA English DT Article ID FLOW-INDUCED VIBRATIONS; CROSS-FLOW; ARRAY; INSTABILITY; STABILITY; CYLINDERS C1 ONTARIO HYDRO,DIV RES,TORONTO M8Z 5S4,ONTARIO,CANADA. RP LEVER, JH (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 32 TC 7 Z9 7 U1 1 U2 1 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0889-9746 J9 J FLUID STRUCT JI J. Fluids Struct. PD JUL PY 1993 VL 7 IS 5 BP 471 EP 496 DI 10.1006/jfls.1993.1030 PG 26 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA LN198 UT WOS:A1993LN19800003 ER PT J AU OWSLEY, DW MANN, RW CHAPMAN, RE MOORE, E COX, WA AF OWSLEY, DW MANN, RW CHAPMAN, RE MOORE, E COX, WA TI POSITIVE IDENTIFICATION IN A CASE OF INTENTIONAL EXTREME FRAGMENTATION SO JOURNAL OF FORENSIC SCIENCES LA English DT Note DE PHYSICAL ANTHROPOLOGY; HUMAN IDENTIFICATION; TAPHONOMIC EFFECTS; FRAGMENTATION; COMPUTER IMAGING AB The investigation of the first of the murders of young males to which Jeffrey Dahmer confessed led to systematic survey of two acres of semirural property in Bath Township, Ohio. The survey revealed the fragmentary skeleton of a young adult male, as well as bones of several species of animals. Through archaeobiological analysis, the animal bones were identified and taphonomic modifications documented. The human bones were dry and weathered, and many were rodent-gnawed, indicating that they had been exposed for many years. The human bones displayed an extreme degree of splintering, warping, bending, and spiral breakage. The only relatively complete bone was a cervical vertebra. Dismemberment and breakage had been accomplished by cutting, blunt force, and, in the case of the ribs, manual bending. Even in so extreme a case of intentional fragmentation, however, forensic anthropological analysis resulted in positive identification, with the primary criteria based on matching osteological features evident in premortem and postmortem radiographs of a cervical vertebra. C1 USA,CENT IDENTIFICAT LAB,HICKAM AFB,HI. RP OWSLEY, DW (reprint author), NATL MUSEUM NAT HIST,DEPT ANTHROPOL,MS 112,WASHINGTON,DC 20560, USA. NR 3 TC 7 Z9 7 U1 1 U2 3 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD JUL PY 1993 VL 38 IS 4 BP 985 EP 996 PG 12 WC Medicine, Legal SC Legal Medicine GA LM756 UT WOS:A1993LM75600035 PM 8355016 ER PT J AU JOHNS, DD ABT, SR WATSON, CC COMBS, PG AF JOHNS, DD ABT, SR WATSON, CC COMBS, PG TI RIPRAP SIZING FOR ARS-TYPE LOW-DROP STILLING BASINS SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Note C1 COLORADO STATE UNIV,DEPT CIVIL ENGN,FT COLLINS,CO 80523. USA,CORPS ENGINEERS,RIVER STABILIZAT BRANCH,VICKSBURG,MS 39181. RP JOHNS, DD (reprint author), CH2M HILL INC,DENVER,CO 80222, USA. NR 8 TC 1 Z9 1 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JUL PY 1993 VL 119 IS 7 BP 864 EP 869 DI 10.1061/(ASCE)0733-9429(1993)119:7(864) PG 6 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA LH279 UT WOS:A1993LH27900007 ER PT J AU QIAN, CG GUO, ZM PETERS, CJ LIU, CT AF QIAN, CG GUO, ZM PETERS, CJ LIU, CT TI PLATELET-ACTIVATING-FACTOR (PAF)-INDUCED CARDIOPULMONARY DYSFUNCTIONS AND THEIR REVERSAL WITH A PAF ANTAGONIST (BN 52021) IN STRAIN 13 GUINEA-PIGS SO JOURNAL OF LIPID MEDIATORS LA English DT Article DE PAF; PAF ANTAGONIST; CARDIOPULMONARY FUNCTION ID PICHINDE VIRUS; RECEPTOR ANTAGONIST; RATS; INFLAMMATION; RABBIT; EVENTS; POTENT AB Cardiovascular and respiratory responses to a 2 h intravenous constant infusion of PAF (5 and 10 ng/kg per min) were studied in strain 13 guinea pigs. PAF decreased arterial blood pressure, left systolic ventricular pressure, and cardiac output (CO). These cardiovascular changes were dose-dependent. The PAF-induced hypotension returned to a pre-infusion level spontaneously with increased total peripheral resistance despite continuous infusion of PAF. The decreased CO was most striking, and did not recover to pre-infusion levels due to depressed cardiac contractility and impaired ventricular relaxation. Respiratory responses to PAF infusion at these doses were mild and only occurred after serious cardiovascular dysfunctions developed. A higher dose of PAF (20 ng/kg per min) produced drastically decreased CO and dynamic lung compliance (C(dyn)), increased pulmonary airway resistance, hypoventilation and apnea within 10-40 min. BN 52021. a PAF receptor antagonist, administered as a single i.v. dose (6 mg/kg) 15 min after PAF infusion, reversed most of cardiopulmonary dysfunctions and prevented death by increasing cardiac contractility, CO, and minute volume from extremely low values. The data suggest that marked cardiopulmonary disturbances induced by intravenous PAF infusion reflects certain pathophysiological mechanisms of diseases that may involve the cellular release of PAF. The administration of BN 52021 or other potent PAF antagonists may be beneficial under these circumstances. C1 USA,MED RES INST INFECT DIS,DEPT CLIN & EXPTL PHYSIOL,DIV DIS ASSESSMENT,FREDERICK,MD 21702. NR 27 TC 7 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-8319 J9 J LIPID MEDIATOR JI J. Lipid Mediat. PD JUL PY 1993 VL 7 IS 3 BP 223 EP 237 PG 15 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA LW192 UT WOS:A1993LW19200002 PM 8219003 ER PT J AU SAVIANO, TJ AF SAVIANO, TJ TI PLEASURE BOATS AND THE LIMITATION OF LIABILITY ACT SO JOURNAL OF MARITIME LAW AND COMMERCE LA English DT Article C1 USA,JUDGE ADVOCATE GEN CORPS,WASHINGTON,DC 20310. NR 31 TC 1 Z9 1 U1 0 U2 0 PU JEFFERSON LAW BOOK COMPANY PI BALTIMORE PA 2100 HUNTINGDON AVE, BALTIMORE, MD 21211 SN 0022-2410 J9 J MARIT LAW COMMER JI J. Marit. Law Commer. PD JUL PY 1993 VL 24 IS 3 BP 519 EP 559 PG 41 WC International Relations; Law SC International Relations; Government & Law GA MD939 UT WOS:A1993MD93900003 ER PT J AU BOMBARD, CF AF BOMBARD, CF TI STRATEGIC-PLANNING - A PRACTICAL APPROACH SO JOURNAL OF NURSING ADMINISTRATION LA English DT Article AB A successful organization, whether a corporation or a department within that corporation, will, in most instances, have a plan, a blueprint for action, that establishes goals and a direction for the future. The author outlines initial and subsequent efforts of the department of nursing at a large military medical center to establish an annual strategic planning conference and to develop implement, and maintain a department of nursing strategic plan. C1 BROOKE ARMY MED CTR,DEPT NURSING,SAN ANTONIO,TX. RP BOMBARD, CF (reprint author), ARMY NURSE CORPS,7TH MED COMMAND,HEIDELBERG,GERMANY. NR 3 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-0443 J9 J NURS ADMIN JI J. Nurs. Adm. PD JUL-AUG PY 1993 VL 23 IS 7-8 BP 41 EP 45 DI 10.1097/00005110-199307000-00012 PG 5 WC Nursing SC Nursing GA LT194 UT WOS:A1993LT19400015 PM 8360765 ER PT J AU JOHNSON, WM BUSNARDO, MS AF JOHNSON, WM BUSNARDO, MS TI SILICOSIS FOLLOWING EMPLOYMENT IN THE MANUFACTURE OF SILICA FLOUR AND INDUSTRIAL SAND SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID SANDBLASTERS AB We describe silicosis in a patient with chronic obstructive pulmonary disease who worked as a maintenance mechanic for less than 5 years in a plant in South Carolina that manufactures silica flour and industrial sand An open lung biopsy showed an early stage of silicosis manifested by perivascular and peribronchial collections of macrophages as well as early granuloma formation. A n antinuclear antibody profile compatible with Sjogren's syndrome or systemic lupus erythematosus occurred with no symptoms of either disease. Excessive occupational exposure levels of respirable free silica were documented. C1 DWIGHT D EISENHOWER ARMY MED CTR,DEPT PATHOL,FT GORDON,GA 30905. RP JOHNSON, WM (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,DEPT MED,PULM DIS SERV,FT GORDON,GA 30905, USA. NR 24 TC 6 Z9 6 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUL PY 1993 VL 35 IS 7 BP 716 EP 719 DI 10.1097/00043764-199307000-00015 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA LP146 UT WOS:A1993LP14600012 PM 8366396 ER PT J AU BUTLER, RCD VORONO, AA FINSTUEN, K AF BUTLER, RCD VORONO, AA FINSTUEN, K TI DOSAGE EFFECTS OF PULSED STEROID-THERAPY ON SERUM CORTISOL-LEVELS IN ORAL AND MAXILLOFACIAL SURGERY PATIENTS SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID DEXAMETHASONE C1 BROOKE ARMY MED CTR,ORAL & MAXILLOFACIAL SURG SERV,FT SAM HOUSTON,TX 78234. ACAD HLTH SCI,US ARMY BAYLOR UNIV GRAD PROGRAM HLTH CARE ADM,HLTH CARE ORG & ANAL BRANCH,FT SAM HOUSTON,TX. BROOKE ARMY MED CTR,ORAL & MAXILLOFACIAL SURG TRAINING PROGRAM,FT SAM HOUSTON,TX 78234. NR 21 TC 7 Z9 7 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD JUL PY 1993 VL 51 IS 7 BP 750 EP 753 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LJ406 UT WOS:A1993LJ40600007 PM 8509913 ER PT J AU DONOVAN, MG ONDRA, SL ILLIG, JJ DICKERSON, NC AF DONOVAN, MG ONDRA, SL ILLIG, JJ DICKERSON, NC TI COMBINED TRANSMANDIBULAR-ZYGOMATIC APPROACH AND INFRATEMPORAL CRANIOTOMY FOR INTRACRANIAL SKULL BASE TUMORS SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID FOSSA APPROACH; LESIONS; ACCESS; ORBIT C1 WALTER REED ARMY MED CTR,NEUROSURG SERV,WASHINGTON,DC 20307. RP DONOVAN, MG (reprint author), WILLIAM BEAUMONT ARMY MED CTR,DEPT ORAL & MAXILLOFACIAL SURG,ORAL & MAXILLOFACIAL SURG SERV,EL PASO,TX 79920, USA. NR 11 TC 12 Z9 15 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD JUL PY 1993 VL 51 IS 7 BP 754 EP 758 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LJ406 UT WOS:A1993LJ40600008 PM 8509914 ER PT J AU PEACOCK, ME SUTHERLAND, DE SCHUSTER, GS BRENNAN, WA ONEAL, RB STRONG, SL VANDYKE, TE AF PEACOCK, ME SUTHERLAND, DE SCHUSTER, GS BRENNAN, WA ONEAL, RB STRONG, SL VANDYKE, TE TI THE EFFECT OF NICOTINE ON REPRODUCTION AND ATTACHMENT OF HUMAN GINGIVAL FIBROBLASTS IN-VITRO SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE CONNECTIVE TISSUE ATTACHMENT; FIBROBLASTS; NICOTINE ADVERSE EFFECTS; SMOKING ADVERSE EFFECTS ID PERIODONTAL-DISEASE; CIGARETTE-SMOKING; POLYMORPHONUCLEAR LEUKOCYTES; TOBACCO-SMOKE; ASSOCIATION; COTININE; PLASMA; GRAFT AB THE ABILITY OF FIBROBLASTS TO REPRODUCE and attach to teeth is of paramount importance in re-establishing the lost connective tissue attachment after periodontal therapy. This study examined the effect of nicotine, a major component of the particulate phase of tobacco smoke, on human gingival fibroblast (HGF) reproduction and attachment to tissue culture surfaces. Pooled HGF cultures made from explants of gingival biopsies were utilized between passages 5 and 10 and plated in 96-well plates at 1.0 x 10(4) cells per well. Cell numbers were determined using 3-(4,5-dimethylthiazol-2-y)-2,5-diphenyl tetrazolium bromide (MTT), which is a reflection of mitochondrial dehydrogenase activity. The concentrations of nicotine used were 0.025, 0.05, 0.1, 0.2, and 0.4 muM, the average serum concentration for a smoker being approximately 0.1 muM. The effect of continuous nicotine exposure on HGF reproduction was determined by incubating cell cultures and media containing nicotine for up to 48 hours. Residual toxicity was determined by preincubating cells with nicotine for 1 or 6 hours. HGF suspensions and increasing concentrations of nicotine were added together to determine the effect on attachment. Results showed an enhanced effect of nicotine on HGF attachment, with increasing numbers of cells attaching with increasing nicotine concentrations, compared to the control. Low concentrations of nicotine had a stimulatory effect on cell replication, while higher concentrations of nicotine appear to have no significant effect on HGF reproduction. The responses of cells to some concentrations of nicotine may persist after its removal. C1 MED COLL GEORGIA,AUGUSTA,GA 30912. UNIV MICHIGAN,ANN ARBOR,MI 48109. EASTMAN DENT CTR,ROCHESTER,NY 14620. RP PEACOCK, ME (reprint author), USA,DENT ACTIV,PERIODONTAL RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. NR 38 TC 72 Z9 76 U1 0 U2 4 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD JUL PY 1993 VL 64 IS 7 BP 658 EP 665 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LP673 UT WOS:A1993LP67300011 PM 8366415 ER PT J AU BROWN, ND BUTLER, DL CHIANG, PK AF BROWN, ND BUTLER, DL CHIANG, PK TI STABILIZATION OF THYMOPENTIN AND PRESERVATION OF ITS PHARMACOLOGICAL PROPERTIES BY 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN SO JOURNAL OF PHARMACY AND PHARMACOLOGY LA English DT Note ID ANATOXIN-A; RECEPTOR; AGONIST AB Thymopentin prepared in 5, 15, and 20% 2-hydroxypropyl-beta-cyclodextrin (HPCD) was able to inhibit guinea-pig ileum contraction stimulated by anatoxin-a (3 x 10(-6) M) after fourteen months of storage at room temperature. Thus, in contrast to the instability of thymopentin prepared without HPCD, the pharmacological activity was retained and could be stored in a ready-to-use solution for extended periods without refrigeration. RP BROWN, ND (reprint author), WALTER REED ARMY INST RES,DEPT APPL BIOCHEM,WASHINGTON,DC 20307, USA. NR 13 TC 7 Z9 8 U1 0 U2 0 PU ROYAL PHARMACEUTICAL SOC GREAT BRITAIN PI LONDON PA 1 LAMBETH HIGH ST, LONDON, ENGLAND SE1 7JN SN 0022-3573 J9 J PHARM PHARMACOL JI J. Pharm. Pharmacol. PD JUL PY 1993 VL 45 IS 7 BP 666 EP 667 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA LN642 UT WOS:A1993LN64200019 PM 8105066 ER PT J AU MCCARTNEY, JW DOUD, R AF MCCARTNEY, JW DOUD, R TI PASSIVE ADAPTATION OF THE PROSTHESIS-IMPLANT INTERFACE BY SOLDERING GOLD CYLINDERS TO THE FRAMEWORK CASTING SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID LONGITUDINAL CLINICAL EFFECTIVENESS; OSSEOINTEGRATED DENTAL IMPLANTS; TORONTO AB Difficulties associated with accuracy of conventional long-span one-piece castings for fixed partial dentures are also observed in the fabrication of implant-supported prostheses. A technique is proposed whereby direct intraoral verification of cylinder-abutment relationship, master cast accuracy, possible corrected cast procedures, and soldering of gold cylinders to the framework ensure an accurate, passive adaptation of the prosthesis to all supporting implants. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP MCCARTNEY, JW (reprint author), DEPT VET AFFAIRS MED CTR,CENT DENT LAB 160L,50 IRVING ST NW,WASHINGTON,DC 20422, USA. NR 4 TC 13 Z9 14 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUL PY 1993 VL 70 IS 1 BP 17 EP 20 DI 10.1016/0022-3913(93)90031-I PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LJ848 UT WOS:A1993LJ84800005 PM 8103559 ER PT J AU RYSKA, TA AF RYSKA, TA TI COPING STYLES AND RESPONSE DISTORTION ON SELF-REPORT INVENTORIES AMONG HIGH-SCHOOL ATHLETES SO JOURNAL OF PSYCHOLOGY LA English DT Article ID STATE ANXIETY; PERCEPTIONS AB In the present study, I examined the relationship between social desirability, competitive state anxiety, and perceived coach support among male and female high school tennis players (N = 270). On the basis of SCAT (Martens, 1977) and M-C SDS scores (Crowne & Marlowe, 1960), I developed four stress coping style groups. Results did not reveal significant differences between these groups on the reporting of CSAI-2 (Martens, Burton, Vealey, Bump, & Smith, 1982) subscales. However, athletes high in social desirability reported significantly greater coach support than athletes low in social desirability, F(1, 269) = 6.24, p < .02. These conflicting results suggest that the effect of response distortion on self-report measures be more closely scrutinized according to variables such as sport type, level of expertise, and degree of mental skills training. The continued use of social desirability instruments is encouraged to assess the general accuracy of conclusions drawn from self-report data. RP RYSKA, TA (reprint author), US MIL ACAD,DEPT PHYS EDUC,ARVIN GYMNASIUM,W POINT,NY 10996, USA. NR 30 TC 2 Z9 2 U1 3 U2 4 PU HELDREF PUBLICATIONS PI WASHINGTON PA 1319 EIGHTEENTH ST NW, WASHINGTON, DC 20036-1802 SN 0022-3980 J9 J PSYCHOL JI J. Psychol. PD JUL PY 1993 VL 127 IS 4 BP 409 EP 418 PG 10 WC Psychology, Multidisciplinary SC Psychology GA MB749 UT WOS:A1993MB74900005 ER PT J AU CHEOK, KC OVERHOLT, JL BECK, RR AF CHEOK, KC OVERHOLT, JL BECK, RR TI EXACT METHODS FOR DETERMINING THE KINEMATICS OF A STEWART PLATFORM USING ADDITIONAL DISPLACEMENT SENSORS SO JOURNAL OF ROBOTIC SYSTEMS LA English DT Article AB The Stewart platform (SP) is a parallel closed-kinematic chain robotic mechanism that is capable of providing high structural and positional rigidity. Because of its unique capability, the platforms have been employed in many control engineering applications such as simulator shakers, robotic manipulators, etc. However, a main problem often found in the implementation of a real-time controller for the platform is the lack of an efficient algorithm for solving its highly nonlinear forward kinematic transformation (FKT), where one seeks to find the translational and orientational altitudes of the moveable platform from knowing the lengths of the platform linkages. This article describes two new direct and exact methods for computing the translational and rotational displacements of an SP by employing extra translational displacement sensors (TDSs), in addition to the existing TDSs for the six links of the SP. The key for the approach lies in knowing where to employ the TDSs for determining positional vectors of strategic platform locations. By taking advantage of a tetrahedral geometry, closed-form solutions for the FKT can then be derived and directly evaluated. The new methods produce accurate solutions with only minimal computation necessary. The advantages and disadvantages of the proposed methods are discussed and compared to an existing method. The exact methods are being investigated for an on-line implementation of a nonlinear adaptive control system and redundancy scheme for a 25-ton Stewart platform-based Crew Station/Turret Motion Base Simulator (CS/TMBS) at the U.S. Army Tank-Automotive Command (TACOM). RP CHEOK, KC (reprint author), USA,TANK AUTOMOT COMMAND,AMSTA RY,DIV SYST SIMULAT & TECHNOL,WARREN,MI 48397, USA. NR 16 TC 39 Z9 41 U1 0 U2 1 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0741-2223 J9 J ROBOTIC SYST JI J. Robot. Syst. PD JUL PY 1993 VL 10 IS 5 BP 689 EP 707 DI 10.1002/rob.4620100508 PG 19 WC Robotics SC Robotics GA LG775 UT WOS:A1993LG77500007 ER PT J AU NICELY, ER MAGGIO, MI BROWN, CE AF NICELY, ER MAGGIO, MI BROWN, CE TI EXTRACORPOREAL SHOCK-WAVE LITHOTRIPSY TREATMENT OF LOWER CALICEAL STONES - AN UPDATE ON THE USE OF A COBRA CATHETER FOR DIRECT IRRIGATION SO JOURNAL OF STONE DISEASE LA English DT Article AB As the general experience with extracorporeal shock wave lithotripsy (ESWL) for renal calculi broadens, it is increasingly evident that the clearance of stone fragments in lower pole calices needs to be improved. The stone-free rate posttreatment for lower caliceal stones is consistently less than that for other upper tract locations. Utilization of a cystoscopically placed cobra catheter for directed irrigation during ESWL with a Dornier HM4 lithotripter resulted in an increase of our lower caliceal stone-free rate to 64% (29/45) at 1 month follow-up and 73% (33/45) at 3 months follow-up compared to 36% (15/42) of randomly selected controls at 1 month (p < 0.007) and 54% (23/42) at 3 months (p < 0.070). Patients were included in the study if they had a solitary calculus, < 2 cm in size, located in a normal lower pole calix and had no indwelling stent placed by the referring physician. The cobra catheter was positioned in the appropriate calix with fluoroscopic guidance under intravenous sedation. Statistical analysis was performed using Pearson's Chi-square test. We conclude that the pre-ESWL treatment placement of a cobra catheter into the lower pole calix and intermittent irrigation during the procedure is a useful adjunct in the successful treatment of lower caliceal calculi. RP NICELY, ER (reprint author), WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FUTURA PUBL CO PI ARMONK PA 135 BEDFORD RD, PO BOX 418, ARMONK, NY 10504-0418 SN 1059-9509 J9 J STONE DIS PD JUL PY 1993 VL 5 IS 3 BP 155 EP 158 PG 4 WC Gastroenterology & Hepatology; Urology & Nephrology SC Gastroenterology & Hepatology; Urology & Nephrology GA LW648 UT WOS:A1993LW64800003 PM 10146233 ER PT J AU SRINIVASAN, GR RAGHAVAN, V DUQUE, EPN MCCROSKEY, WJ AF SRINIVASAN, GR RAGHAVAN, V DUQUE, EPN MCCROSKEY, WJ TI FLOWFIELD ANALYSIS OF MODERN HELICOPTER ROTORS IN HOVER BY NAVIER-STOKES METHOD SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID BLADE; FLOW AB The viscous, three-dimensional flowfields of UH-60A and BERP rotors are calculated for lifting hover configurations using a Navier-Stokes computational fluid dynamics method, called TURNS, with a view to understand the importance of planform effects on the airloads. The solution scheme is essentially a free-wake method. That is, the induced effects of the wake, including the interaction of tip vortices with successive blades, are captured as a part of the overall flowfield solution without prescribing the structure or position of the vortical wake. However, the structure of the captured tip vortex is diffused by numerical viscosity. Calculated results are presented for the UH-60A and BERP rotors in the form of surface pressures, hover performance parameters, surface particle flow, tip vortex, and vortex wake trajectory at two thrust conditions. The results for the UH-60A model rotor agree well with experiments for a moderate thrust condition. Comparison of UH-60A results with an equivalent rectangular UH-60A blade and a high-twist BERP blade indicates that the BERP blade, with an unconventional planform, produces more thrust at a given collective pitch, and approximately the same Figure of Merit. The high thrust conditions considered produce severe shock-induced flow separation for the UH-60A blade, while the BERP blade develops more thrust and minimal separation. The BERP blade produces a tighter tip vortex structure compared with the UH-60A blade. These results and the discussion presented bring out the similarities and differences between the two rotors. C1 JAI ASSOCIATES INC,MT VIEW,CA 94042. STERLING SOFTWARE INC,FED SYST GRP,PALO ALTO,CA. USA,AEROFLIGHTDYNAM DIRECTORATE,MOFFETT FIELD,CA 94035. RP SRINIVASAN, GR (reprint author), NASA,AMES RES CTR,MOFFETT FIELD,CA 94035, USA. NR 18 TC 26 Z9 29 U1 0 U2 1 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 1993 VL 38 IS 3 BP 3 EP 13 PG 11 WC Engineering, Aerospace SC Engineering GA ME845 UT WOS:A1993ME84500001 ER PT J AU VISINTAINER, JA MARCOLINI, MA BURLEY, CL LIU, SR AF VISINTAINER, JA MARCOLINI, MA BURLEY, CL LIU, SR TI ACOUSTIC PREDICTIONS USING MEASURED PRESSURES FROM A MODEL ROTOR IN THE DNW SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB A contemporary design, 4-bladed United Technologies model rotor with pressure-instrumented blades was tested in the Duits-Nederlandse Windtunnel. Simultaneous acoustic and pressure measurements were made for a wide range of operating conditions. Microphones were positioned at a number of locations in the flow forward of the rotor to measure rotor thickness noise and high-speed impulsive noise (in the rotor plane), and blade-vortex interaction noise (forward and below the rotor plane). The blade surface pressure data are used as aerodynamic input to WOPWOP, which is a rotor noise prediction program that predicts thickness and loading noise. The predicted results using WOPWOP are compared to the measured noise levels for cases where either the noise, blade-vortex interaction noise, or high-speed impulsive noise is the dominant noise mechanism. The comparisons show regions of good agreement, as well as areas where further improvement is necessary. C1 NASA,LANGLEY RES CTR,HAMPTON,VA 23665. USA,AEROFLIGHTDYNAM DIRECTORATE,MOFFETT FIELD,CA. RP VISINTAINER, JA (reprint author), UNITED TECHNOL CORP,SIKORSKY AIRCRAFT DIV,STRATFORD,CT 06601, USA. NR 18 TC 8 Z9 8 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 1993 VL 38 IS 3 BP 35 EP 44 PG 10 WC Engineering, Aerospace SC Engineering GA ME845 UT WOS:A1993ME84500004 ER PT J AU YEAGER, WT MIRICK, PH HAMOUDA, MNH WILBUR, ML SINGLETON, JD WILKIE, WK AF YEAGER, WT MIRICK, PH HAMOUDA, MNH WILBUR, ML SINGLETON, JD WILKIE, WK TI ROTORCRAFT AEROELASTIC TESTING IN THE LANGLEY TRANSONIC DYNAMICS TUNNEL SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB Wind-tunnel testing of a properly scaled aeroelastic model helicopter rotor is considered critical to the design and development of new rotor systems. For this reason, extensive testing or aeroelastically scaled model rotors is done in the Transonic Dynamics Tunnel (TDT) located at the Langley Research Center. A unique capability of this facility, which enables proper dynamic scaling, is the use of difluorodichloromethane, or Refrigerant-12 (R-12) as a test medium. The paper presents a description of the TDT and a discussion of the benefits of using R-12 as a test medium. A description of the system used to conduct model tests is provided, as well as examples of typical rotor tests conducted in the TDT. RP YEAGER, WT (reprint author), USA,VEHICLE STRUCT DIRECTORATE,NASA,LANGLEY RES CTR,HAMPTON,VA, USA. NR 25 TC 1 Z9 1 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 1993 VL 38 IS 3 BP 73 EP 82 PG 10 WC Engineering, Aerospace SC Engineering GA ME845 UT WOS:A1993ME84500008 ER PT J AU BANISH, LD SIMS, R SACK, D MONTALI, RJ PHILLIPS, L BUSH, M AF BANISH, LD SIMS, R SACK, D MONTALI, RJ PHILLIPS, L BUSH, M TI PREVALENCE OF SHIGELLOSIS AND OTHER ENTERIC PATHOGENS IN A ZOOLOGIC COLLECTION OF PRIMATES SO JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Article ID FECAL LEUKOCYTES; RESISTANT AB An epidemiologic study of shigellosis was the preliminary step in the formulation of a plan for the control of devastating infectious diseases in nonhuman primates at the National Zoological Park. Data were collected from primate groups with enzootic shigellosis and included the following species: white-cheeked and siamang gibbons (Hylobates concolor and H syndactylies); lion-tailed, celebes, and Barbary macaques (Macaca silenus, M nigera, and M sylvanus); black and white colobus monkeys (Colobus guerzea); grey-cheeked mangabeys (Cerecocebus albigena); spider monkeys (Ateles susciceps robusuts); ruffed lemurs (Lemur varrigatus); lowland gorillas (Gorilla gorilla); and orangutans (pongo pygmaeus). Data included results of physical examination, proctoscopy with biopsy, fecal parasitologic and cytologic examinations, and bacteriologic culturing of swabbed specimens of rectum and gingiva. Repetitive fecal examinations were subsequently performed and included bacteriologic culturing of fecal specimens for enteropathogenic bacteria and parasites and cytologic examination of feces. Data were collected for a 1-year period from 82 primates, and 14 gibbons were studied intensively. White-cheeked and siamang gibbons shed Shigella flexneri sporadically, but persistently. All gibbons were affected with a mean point prevalence of 30.7% (range 0 to 71%). Shigella flexneri also was isolated from feces of lion-tailed macaques. Shigella sonnei was isolated from feces of grey-cheeked mangabeys, celebes macaques, and spider monkeys. Of 180 colonic mucosal biopsy specimens from 60 primates, 3 contained Shigella spp. Most S flexneri isolates were serotype Y. Our findings substantiated that enzootic shigellosis was more widespread at the National Zoological Park than signs of disease and results of a few bacteriologic cultures suggested. Those primate species affected were pinpointed, and the heterogeneity of Shigella spp involved was elucidated. Supportive diagnostic techniques were investigated and an unconventional protocol for performing bacteriologic culturing of fecal specimens was found useful in decreasing false-negative results. Epidemiologic findings and shedding patterns defined appropriateness of clinical management options. C1 SMITHSONIAN INST,NATL ZOOL PK,DEPT PATHOL,WASHINGTON,DC 20008. DEPT LAB SERV,DIV PATHOL,WALTER REED ARMY INST RES,WASHINGTON,DC 20012. JOHNS HOPKINS UNIV,SCH PUBL HLTH,DEPT INT MED,BALTIMORE,MD 21205. RP BANISH, LD (reprint author), SMITHSONIAN INST,NATL ZOOL PK,DEPT ANIM HLTH,WASHINGTON,DC 20008, USA. NR 15 TC 16 Z9 16 U1 1 U2 9 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 SN 0003-1488 J9 J AM VET MED ASSOC JI J. Am. Vet. Med. Assoc. PD JUL 1 PY 1993 VL 203 IS 1 BP 126 EP 132 PG 7 WC Veterinary Sciences SC Veterinary Sciences GA LK830 UT WOS:A1993LK83000029 PM 8407446 ER PT J AU BANISH, LD SIMS, R BUSH, M SACK, D MONTALI, RJ AF BANISH, LD SIMS, R BUSH, M SACK, D MONTALI, RJ TI CLEARANCE OF SHIGELLA-FLEXNERI CARRIERS IN A ZOOLOGIC COLLECTION OF PRIMATES SO JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Article ID ARTHROPATHY; MONKEYS AB In 1990, a high prevalence of Shigella flexneri was documented in the gibbon population at the National Zoological Park. The enzootic strain had been determined to be resistant to most antibiotics and had been responsible for animal deaths. Prevalence of Shigella spp was high in the entire primate population. To address the clinical problem, eradication was attempted by use of enrofloxacin. Facilities disinfection comprised a large part of Shigella clearance efforts. After the clearance protocol was completed gibbons, vs other primate species, were closely monitored for 16 months by subjecting their feces to bacteriologic culturing. The program was successful, with eradication Of the problematic strain of S flexneri. However, 10 to 12 months after completion of treatments, S sonnei was isolated from feces of 3 animals living in the same housing facility. C1 SMITHSONIAN INST,NATL ZOOL PK,DEPT PATHOL,WASHINGTON,DC 20008. DEPT LAB SERV,DIV PATHOL,WALTER REED ARMY INST RES,WASHINGTON,DC 20012. JOHNS HOPKINS UNIV,SCH PUBL HLTH,DEPT INTERNAL MED,BALTIMORE,MD 21205. RP BANISH, LD (reprint author), SMITHSONIAN INST,NATL ZOOL PK,DEPT ANIM HLTH,WASHINGTON,DC 20008, USA. NR 15 TC 9 Z9 9 U1 2 U2 2 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 SN 0003-1488 J9 J AM VET MED ASSOC JI J. Am. Vet. Med. Assoc. PD JUL 1 PY 1993 VL 203 IS 1 BP 133 EP 136 PG 4 WC Veterinary Sciences SC Veterinary Sciences GA LK830 UT WOS:A1993LK83000030 PM 8407447 ER PT J AU LAMAR, CR AF LAMAR, CR TI ANALYTICAL SOLUTION FOR THERMAL RUNAWAY IN THE SURFACE HEATING OF PLATES SO JOURNAL OF THERMOPHYSICS AND HEAT TRANSFER LA English DT Note RP LAMAR, CR (reprint author), USA,STRATEG DEF COMMAND,DIV HIGH ENERGY LASER,DIRECTED ENERGY DIRECTORATE,HUNTSVILLE,AL 35807, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0887-8722 J9 J THERMOPHYS HEAT TR JI J. Thermophys. Heat Transf. PD JUL-SEP PY 1993 VL 7 IS 3 BP 538 EP 540 DI 10.2514/3.455 PG 3 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA LN868 UT WOS:A1993LN86800025 ER PT J AU AZAROW, KS PEARL, RH ZURCHER, R EDWARDS, FH COHEN, AJ AF AZAROW, KS PEARL, RH ZURCHER, R EDWARDS, FH COHEN, AJ TI PRIMARY MEDIASTINAL MASSES - A COMPARISON OF ADULT AND PEDIATRIC POPULATIONS SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY LA English DT Article ID PRIMARY CYSTS; TUMORS; CHILDREN; MANAGEMENT AB Since 1944 62 pediatric patients with primary cysts and tumors of the mediastinum have been operated on at our institution. We compared this group with 195 adult patients with similar diagnoses who were operated on during this period. Comparisons were made with regard to histologic type, location, presenting symptoms, physical findings, and surgical complications. We found significant increases in the prevalence of lymphoma in adults (41/195 versus 4/62, p < 0.05) and of neurogenic tumors in children (21/62 versus 24/195, p < 0.05). There were no significant differences in the prevalence of thymic tumors (51/195 versus 22/62), germ cell tumors (24/195 versus 4/62), and cysts (32/195 versus 15/62). There was no difference in the prevalence of symptomatic patients (99/195 versus 36/62). The prevalence of malignancy has increased in both groups since 1970 (2/28 versus 16/34 in children, p < 0.01; and 14/56 versus 69/139 in adults, p < 0.05). This is attributed to a rise in the prevalence of malignant neurogenic tumors in children and to an increase in the prevalence of lymphomas in adults. Tumor size, location, and the presence of symptoms were predictive of malignancy in the adult population but not in the pediatric population. No difference existed in mortality and morbidity between the two groups. All three pediatric deaths were directly related to loss of airway control as a result of mass effect from the tumor. Definite differences exist between the adult and pediatric populations with regard to mediastinal tumors. These differences need to be considered carefully when evaluating and planning treatment for a child with a mediastinal mass. C1 WALTER REED ARMY MED CTR,DEPT THORAC SURG,THORAC SURG SERV,4TH FLOOR,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV PEDIAT SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. NR 17 TC 63 Z9 66 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-5223 J9 J THORAC CARDIOV SUR JI J. Thorac. Cardiovasc. Surg. PD JUL PY 1993 VL 106 IS 1 BP 67 EP 72 PG 6 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA LM053 UT WOS:A1993LM05300007 PM 8321006 ER PT J AU PRUITT, BA AF PRUITT, BA TI TRAUMA CARE IN WAR AND PEACE - THE ARMY AAST SYNERGISM - 1992 FITTS LECTURE SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 52ND ANNUAL SESSION OF THE AMERICAN ASSOC FOR THE SURGERY OF TRAUMA CY SEP 17-19, 1992 CL LOUISVILLE, KY SP AMER ASSOC SURG TRAUMA ID VASCULAR INJURIES; BURNED PATIENTS; THERMAL INJURY; SURGERY; MANAGEMENT; VIETNAM; REPAIR RP PRUITT, BA (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 90 TC 11 Z9 11 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 1993 VL 35 IS 1 BP 78 EP 87 DI 10.1097/00005373-199307000-00014 PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA LP571 UT WOS:A1993LP57100014 PM 8331717 ER PT J AU GRAVES, TA CIOFFI, WG VAUGHAN, GM PRATT, L HEIRONIMUS, JD MCMANUS, WF PRUITT, BA MACKSIE, RC LUCAS, CE AF GRAVES, TA CIOFFI, WG VAUGHAN, GM PRATT, L HEIRONIMUS, JD MCMANUS, WF PRUITT, BA MACKSIE, RC LUCAS, CE TI THE RENAL EFFECTS OF LOW-DOSE DOPAMINE IN THERMALLY INJURED PATIENTS SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 52ND ANNUAL SESSION OF THE AMERICAN ASSOC FOR THE SURGERY OF TRAUMA CY SEP 17-19, 1992 CL LOUISVILLE, KY SP AMER ASSOC SURG TRAUMA ID GLOMERULAR-FILTRATION RATE; RECEPTOR STIMULATION; NATRIURESIS; INFUSION; DISEASE; FAILURE; SODIUM; WATER; FLOW AB The renal effects of low-dose dopamine (LDD) therapy in hyperdynamic thermally injured patients are unknown. We investigated the renal effects of LDD in ten burn patients (mean +/- SEM age and %total body surface burned: 30.2 +/- 3.3 years and 53.4% +/- 7%) and six controls (mean age; 20.2 +/- 0.5 years). Administration of LDD significantly increased glomerular filtration rate, effective renal plasma flow, sodium excretion, and urine flow in the controls and effective renal plasma flow, urine flow, heart rate, and cardiac index in the patients. The chronotropic effect of dopamine appears to be a principal contributor to the patients' increased effective renal plasma flow. Sodium excretion was increased by LDD only in the patients in whom the pre-dopamine sodium excretion exceeded 5 mEq/h. Lack of a consistent natriuretic effect and the consistent chronotropic effect suggest that the routine use of low-dose dopamine in burn patients is unwarranted. The side effects that attend the desired response determine clinical use, i.e., the potential for blood flow redistribution and increased cardiac work demands must be balanced against increased renal plasma flow and natriuresis. C1 USA,INST SURG RES,SGRD-USC-B,FT SAM HOUSTON,TX 78234. NR 20 TC 24 Z9 25 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 1993 VL 35 IS 1 BP 97 EP 103 DI 10.1097/00005373-199307000-00016 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA LP571 UT WOS:A1993LP57100016 PM 8331720 ER PT J AU HATHAWAY, MD CHRISS, RM WOOD, JR STRAZISAR, AJ AF HATHAWAY, MD CHRISS, RM WOOD, JR STRAZISAR, AJ TI EXPERIMENTAL AND COMPUTATIONAL INVESTIGATION OF THE NASA LOW-SPEED CENTRIFUGAL-COMPRESSOR FLOW-FIELD SO JOURNAL OF TURBOMACHINERY-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 37TH INTERNATIONAL CONGRESS AND EXPOSITION ON GAS TURBINE AND AEROENGINE CY JUN 01-04, 1992 CL COLOGNE, GERMANY AB An experimental and computational investigation of the NASA Low-Speed Centrifugal Compressor (LSCC) flow field has been conducted using laser anemometry and Dawes' three dimensional viscous code. The experimental configuration consists of a backswept impeller followed by a vaneless diffuser. Measurements of the three-dimensional velocity field were acquired at several measurement planes through the compressor. The measurements describe both the throughflow and secondary velocity field along each measurement plane. In several cases the measurements provide details of the flow within the blade boundary layers. Insight into the complex flow physics within centrifugal compressors is provided by the computational analysis, and assessment of the CFD predictions is provided by comparison with the measurements. Five-hole probe and hot-wire surveys at the inlet and exit to the rotor as well as surface flow visualization along the impeller blade surfaces provide independent confirmation of the laser measurement technique. The results clearly document the development of the throughflow velocity wake, which is characteristic of unshrouded centrifugal compressors. C1 NASA,LEWIS RES CTR,CLEVELAND,OH 44135. RP HATHAWAY, MD (reprint author), USA,RES LAB,VEHICLE PROPULS DIRECTORATE,CLEVELAND,OH 44135, USA. NR 27 TC 38 Z9 42 U1 1 U2 10 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0889-504X J9 J TURBOMACH JI J. Turbomach.-Trans. ASME PD JUL PY 1993 VL 115 IS 3 BP 527 EP 542 DI 10.1115/1.2929285 PG 16 WC Engineering, Mechanical SC Engineering GA LP012 UT WOS:A1993LP01200017 ER PT J AU MOUL, JW AF MOUL, JW TI GANGRENE OF PENIS AFTER IMPLANTATION OF PENILE PROSTHESIS - CASE-REPORTS, TREATMENT RECOMMENDATIONS AND REVIEW OF LITERATURE - COMMENT SO JOURNAL OF UROLOGY LA English DT Editorial Material RP MOUL, JW (reprint author), WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUL PY 1993 VL 150 IS 1 BP 192 EP 192 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA LH013 UT WOS:A1993LH01300058 ER PT J AU MCLANE, GF COLE, MW ECKART, DW COOKE, P MOERKIRK, R MEYYAPPAN, M AF MCLANE, GF COLE, MW ECKART, DW COOKE, P MOERKIRK, R MEYYAPPAN, M TI MAGNETRON-ENHANCED REACTIVE ION ETCHING OF GAAS AND ALGAAS USING CH4/H2/AR SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 39TH NATIONAL SYMP OF THE AMERICAN VACUUM SOC CY NOV 09-13, 1992 CL CHICAGO, IL SP AMER VACUUM SOC ID HYDROGEN; METHANE; INP; PASSIVATION; C2H6/H2/AR; MIXTURE; DAMAGE; FIELD; GAS AB Magnetron reactive ion etching of GaAs and AlGaAs has been investigated in CH4/H-2/Ar gas mixtures. Etch rate was determined as a function of gas composition, power density (0.4-1.0 W/cm2), pressure (6-25 mTorr), and total flow rate (20-40 sccm). Scanning electron microscope measurements revealed that anisotropic etching characteristics and smooth etched surfaces can be obtained. Transmission electron microscope measurements showed that the addition of Ar to the gas mixture enhanced surface smoothness, but increased the etch-induced defect depth and density. Hydrogen passivation effects of etched and rapid thermal annealed GaAs were studied for two anneal temperatures (300, 400-degrees-C). C1 SCI RES ASSOCIATES INC,GLASTONBURY,CT 06033. RP MCLANE, GF (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. RI Schaff, William/B-5839-2009 NR 18 TC 21 Z9 21 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD JUL-AUG PY 1993 VL 11 IS 4 BP 1753 EP 1757 DI 10.1116/1.578419 PN 2 PG 5 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA LP008 UT WOS:A1993LP00800022 ER PT J AU SULTAN, NJ HUGHES, SA AF SULTAN, NJ HUGHES, SA TI IRREGULAR WAVE-INDUCED VELOCITIES IN SHALLOW-WATER SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article AB Irregular water waves were generated in a flat-bottomed. two-dimensional wave tank with a partially reflecting spending beach. The horizontal and vertical velocity of the fluid particles was measured with a laser Doppler velocimeter at middepth and near bottom in the water column. The results show that a linear theory equation predicts the root-mean-square (rms) water particle velocity to within 10% given the measured incident wave height spectrum, reflection coefficients, and water depth. An extension of the Gaussian probability distribution based on the Gram-Charlier series was applied to the velocity time series. This extended distribution did not fit the measured data better than the ordinary Gaussian distribution. The Beta-Rayleigh probability distribution function was applied to peak velocities. A slight improvement is observed over the ordinary Rayleigh distribution. The parameters of the Beta-Rayleigh distribution are empirically correlated with parameters of the incident wave spectrum. C1 USA,COASTAL ENGN RES CTR,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP SULTAN, NJ (reprint author), TEXAS A&M UNIV SYST,OCEAN ENGN PROGRAM,COLL STN,TX 77843, USA. NR 13 TC 6 Z9 6 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JUL-AUG PY 1993 VL 119 IS 4 BP 429 EP 447 DI 10.1061/(ASCE)0733-950X(1993)119:4(429) PG 19 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA LJ647 UT WOS:A1993LJ64700006 ER PT J AU KRAUS, NC MASON, JM AF KRAUS, NC MASON, JM TI PREDICTION OF STORM NORMAL BEACH PROFILES - DISCUSSION SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Discussion RP KRAUS, NC (reprint author), USA,ENGN,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 3 TC 2 Z9 2 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JUL-AUG PY 1993 VL 119 IS 4 BP 468 EP 470 DI 10.1061/(ASCE)0733-950X(1993)119:4(468) PG 3 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA LJ647 UT WOS:A1993LJ64700013 ER PT J AU MULLER, WS SAMUELSON, LA FOSSEY, SA KAPLAN, DL AF MULLER, WS SAMUELSON, LA FOSSEY, SA KAPLAN, DL TI FORMATION AND CHARACTERIZATION OF LANGMUIR SILK FILMS SO LANGMUIR LA English DT Article ID FIBROIN MEMBRANE; PHOSPHOLIPID MONOLAYERS; BLODGETT FILMS; SOLID-STATE; IMMOBILIZATION; PROTEIN; SPECTROSCOPY; PENETRATION; SENSORS; MODEL AB Langmuir films were formed from regenerated (solubilized cocoons) Bombyx mori silk. Pressure/area isotherms and deposition studies indicate the formation of stable films; however, due to the molecular weight and solubility nature of silk it has been difficult to determine the area occupied by each protein polymer chain. The thin films were successfully transferred on to various solid supports for analysis. Ellipsometry data indicate a film thickness of 11.6 to 11.9 angstrom. Infrared spectrometry (ATR) shows wavenumbers at the amide bands of 1624 (amide I), 1522 (amide II), 1258 (amide III), and 700.8 (amide V), indicative of a silk II structure. TEM micrographs show pores of 300-3500 A in diameter and electron diffraction analysis indicates a polycrystalline structure. RP MULLER, WS (reprint author), USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760, USA. NR 36 TC 35 Z9 36 U1 1 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0743-7463 J9 LANGMUIR JI Langmuir PD JUL PY 1993 VL 9 IS 7 BP 1857 EP 1861 DI 10.1021/la00031a038 PG 5 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA LN721 UT WOS:A1993LN72100038 ER PT J AU GAZONAS, GA AF GAZONAS, GA TI A UNIAXIAL NONLINEAR VISCOELASTIC CONSTITUTIVE MODEL WITH DAMAGE FOR M30 GUN PROPELLANT SO MECHANICS OF MATERIALS LA English DT Article ID CRACK INITIATION; MEDIA; FRACTURE; GROWTH AB The nonlinear viscoelastic mechanical response of a conventional tank gun propellant, M30, is modeled using a ''modified superposition integral'' that incorporates the effects of microstructural fracture damage. Specifically, a linear, time-dependent kernel is convolved with the first-time derivative of a power-law function of stress and a damage ''softening'' that accounts for damage evolution by a microcrack growth mechanism. The microcrack damage function is a master curve formed from shifted isothermal, compressive, uniaxial constant strain rate (0.01 s-1 to 420 s-1) data on solid, right-circular cylinders of M30 gun propellant. An attractive feature of the model is its ability to predict work-softening behavior under conditions of monotonically increasing deformation. Time-dependent predictions of stress versus time, failure stress versus failure time, and failure stress versus strain rate, quantitatively agree with experimental results from constant strain rate tests on the propellant. Theoretical predictions of time-dependent stresses for Heaviside and ''ballistic-like'' strain histories are also provided. RP GAZONAS, GA (reprint author), USA,RES LAB,DIV PROPULS & FLIGHT,ABERDEEN PROVING GROUND,MD 21005, USA. OI Gazonas, George/0000-0002-2715-016X NR 35 TC 7 Z9 8 U1 2 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-6636 J9 MECH MATER JI Mech. Mater. PD JUL PY 1993 VL 15 IS 4 BP 323 EP 335 DI 10.1016/0167-6636(93)90006-D PG 13 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA LP002 UT WOS:A1993LP00200006 ER PT J AU CARLIN, K CARLIN, S AF CARLIN, K CARLIN, S TI ACID-BASE MAY BE MORE VARIABLE THAN PREVIOUSLY THOUGHT SO MEDICAL HYPOTHESES LA English DT Article ID PERFUSED RAT-LIVER; HYPOXIC LACTIC-ACIDOSIS; INTRACELLULAR PH; SODIUM-BICARBONATE; LIPOPROTEIN-LIPASE; LACTATE UPTAKE; GLUCONEOGENESIS; HEPATOCYTES; TRANSPORT; BINDING AB Organ systems in the human body may not be homogeneous in regard to pH. Possibly specific organ systems under certain conditions maintain a pH level significantly different than the systemic pH. RP CARLIN, K (reprint author), BROOKE ARMY MED CTR,DEPT ENDOCRINOL,FT SAM HOUSTON,TX 78234, USA. NR 43 TC 5 Z9 5 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH, MIDLOTHIAN, SCOTLAND EH1 3AF SN 0306-9877 J9 MED HYPOTHESES JI Med. Hypotheses PD JUL PY 1993 VL 41 IS 1 BP 42 EP 47 DI 10.1016/0306-9877(93)90032-L PG 6 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA LQ100 UT WOS:A1993LQ10000008 PM 8231979 ER PT J AU KING, N SUTHERLAND, MR MUTTER, SH ASKEW, EW ROBERTS, DE AF KING, N SUTHERLAND, MR MUTTER, SH ASKEW, EW ROBERTS, DE TI COLD WEATHER FIELD-EVALUATION OF THE 18-MAN ARCTIC TRAY PACK RATION MODULE, THE MEAL, READY-TO-EAT, AND THE LONG-LIFE RATION PACKET SO MILITARY MEDICINE LA English DT Article AB The Army Field Feeding System was evaluated for its ability to provide adequate nutrition and hydration during a 10-day cold weather field exercise. Soldiers consumed the 18-Man Arctic Tray Pack Ration Module with either a wet-pack (Meal, Ready-to-Eat) or a dehydrated (Long Life Ration Packet) individual ration. Both feeding regimens were acceptable, meeting protein and micronutrients requirements. However, the soldiers consumed only 70% of their energy requirement, thus losing an average of 0.9% of body weight. This weight loss, although not excessive, underscores the importance of maintaining an adequate food intake during extended cold weather military field operations. RP KING, N (reprint author), USA,ENVIRONM MED RES INST,DIV MIL NUTR,NATICK,MA 01760, USA. NR 0 TC 3 Z9 3 U1 0 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1993 VL 158 IS 7 BP 458 EP 465 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA LM843 UT WOS:A1993LM84300011 PM 8351047 ER PT J AU ROSEN, LN TEITELBAUM, JM WESTHUIS, DJ AF ROSEN, LN TEITELBAUM, JM WESTHUIS, DJ TI CHILDRENS REACTIONS TO THE DESERT-STORM DEPLOYMENT - INITIAL FINDINGS FROM A SURVEY OF ARMY FAMILIES SO MILITARY MEDICINE LA English DT Article AB Psychological symptom profiles were obtained on 1,601 children of soldiers deployed during Operation Desert Storm (ODS). The profiles were obtained from reports of the parents who stayed at home with the children. Certain symptoms such as sadness were common, but very few parents considered their children's problems serious enough to require counseling. The strongest predictor of children's receiving counseling during ODS was a previous history of being in counseling for emotional problems. RP ROSEN, LN (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,SGRD UWI A,WASHINGTON,DC 20307, USA. NR 0 TC 46 Z9 46 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1993 VL 158 IS 7 BP 465 EP 469 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA LM843 UT WOS:A1993LM84300012 PM 8351048 ER PT J AU ZADOO, V CATTERSON, M FENGLER, S AF ZADOO, V CATTERSON, M FENGLER, S TI THE EFFECTS OF ALCOHOL AND TOBACCO USE ON TROOP READINESS SO MILITARY MEDICINE LA English DT Article AB Prior studies have documented the ill effects of cigarette smoking on soldier athletic performance. We examined the effects, if any, of cigarette smoking and alcohol use on troop readiness. A group of 510 soldiers was examined. They answered an initial questionnaire and then were followed in sick call for a 2-month period. The results of the study confirmed that cigarette smoking impacted adversely on athletic performance. However, we were unable to quantitate increased time off or away from duty as a result of cigarette smoking and alcohol use. RP ZADOO, V (reprint author), TRIPLER ARMY MED CTR,DEPT GEN SURG,HONOLULU,HI 96818, USA. NR 0 TC 29 Z9 29 U1 1 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1993 VL 158 IS 7 BP 480 EP 484 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA LM843 UT WOS:A1993LM84300016 PM 8351051 ER PT J AU LOCKE, KD AF LOCKE, KD TI NONCOMBATANTS AND THE GENEVA CONVENTION SO MILITARY MEDICINE LA English DT Letter RP LOCKE, KD (reprint author), USA,FT HOOD,TX 76544, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1993 VL 158 IS 7 BP A4 EP A4 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA LM843 UT WOS:A1993LM84300001 ER PT J AU MODESTO, VL AF MODESTO, VL TI DELAYED HEMORRHAGE - RESPONSE SO MILITARY MEDICINE LA English DT Letter RP MODESTO, VL (reprint author), EISENHOWER ARMY MED CTR,DEPT SURG,FT GORDON,GA, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1993 VL 158 IS 7 BP A6 EP A6 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA LM843 UT WOS:A1993LM84300004 ER PT J AU WARE, LA KAIN, KC SIM, BKL HAYNES, JD BAIRD, JK LANAR, DE AF WARE, LA KAIN, KC SIM, BKL HAYNES, JD BAIRD, JK LANAR, DE TI 2 ALLELES OF THE 175-KILODALTON PLASMODIUM-FALCIPARUM ERYTHROCYTE BINDING ANTIGEN SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY LA English DT Article DE PLASMODIUM-FALCIPARUM; ERYTHROCYTE BINDING ANTIGEN; ALLELE ID MEROZOITE INVASION; MALARIA; PARASITE; GLYCOPHORIN; PROTEINS; RECEPTOR AB EBA-175, erythrocyte binding antigen 175, is a 175-kDa antigen of Plasmodium falciparum which has been shown to be involved in the recognition of erythrocytes by merozoites and may be involved in the process of erythrocyte invasion. Invasion of erythrocytes by Camp strain merozoites is inhibited by pre-treatment of red blood cells by EBA-175 from the heterologous strain, FCR-3. The sequence of the Camp strain has been published and we report here the sequence of the FCR-3 strain. The sequences are nearly identical except for a 423-bp segment in the FCR-3 strain, F-segment, that is not found in the Camp strain and a 342-bp segment, C-segment, present in the Camp strain but not in the FCR-3 strain. The locations of these two segments are different in Camp and FCR-3 EBA-175 genes and there is little DNA or amino acid sequence homology between them. The essentially dimorphic alleles, F-segment and C-segment, are conserved in all isolates examined to date. Evidence of genetic cross-over between the FCR-3 and the Camp EBA-175 genes was not observed in the analysis of a limited number of wild isolates. The continued study of the biological relevance of these sequence divergences in EBA-175 may further elucidate the sequence of events resulting in merozoite invasion of erythrocytes. C1 WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. NAMRU,JAKARTA,INDONESIA. TORONTO GEN HOSP,TROP DIS UNIT,TORONTO M5G 1L7,ONTARIO,CANADA. NIH,PARASIT DIS LAB,BETHESDA,MD 20892. RI Lanar, David/B-3560-2011 NR 18 TC 41 Z9 42 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-6851 J9 MOL BIOCHEM PARASIT JI Mol. Biochem. Parasitol. PD JUL PY 1993 VL 60 IS 1 BP 105 EP 110 DI 10.1016/0166-6851(93)90033-T PG 6 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA LL861 UT WOS:A1993LL86100012 PM 8366884 ER PT J AU DAVIS, D JABBARI, B AF DAVIS, D JABBARI, B TI SIGNIFICANT IMPROVEMENT OF STIFF-PERSON SYNDROME AFTER PARASPINAL INJECTION OF BOTULINUM TOXIN-A SO MOVEMENT DISORDERS LA English DT Note DE STIFF-PERSON SYNDROME; BOTULINUM TOXIN-A ID GLUTAMIC-ACID DECARBOXYLASE; DIABETES-MELLITUS; GABAERGIC NEURONS; AUTOANTIBODIES; DISORDER AB Following several months of low back pain, a 36-year-old man developed progressive stiffness of the abdominal, low back, and thigh muscles. On examination, these muscles demonstrated marked hypertonia consistent with the clinical diagnosis of stiff-person syndrome. The patient demonstrated increased lumbar lordosis and had focal hyperhidrosis at different sites. Electromyography showed continuous activity of the paraspinal and thigh muscles, and serum and cerebrospinal fluid antibodies to glutamic acid decarboxylase (GAD) were markedly elevated. Diazepam and Lioresal offered partial pain relief. Paraspinal muscle administration of botulinum toxin A reduced the tone of paraspinal and thigh muscles significantly and resulted in marked improvement of ambulation and cessation of pain. C1 WALTER REED ARMY MED CTR,DEPT PHYS MED & REHABIL,NEUROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT NEUROL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,BETHESDA,MD 20814. NR 29 TC 40 Z9 40 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0885-3185 J9 MOVEMENT DISORD JI Mov. Disord. PD JUL PY 1993 VL 8 IS 3 BP 371 EP 373 DI 10.1002/mds.870080323 PG 3 WC Clinical Neurology SC Neurosciences & Neurology GA LK109 UT WOS:A1993LK10900022 PM 8341305 ER PT J AU BELAY, T HOSPENTHAL, DR ROGERS, AL PATTERSON, MJ AF BELAY, T HOSPENTHAL, DR ROGERS, AL PATTERSON, MJ TI TREATMENT OF SYSTEMIC CANDIDIASIS IN A NEUTROPENIC MURINE MODEL USING IMMUNOGLOBULIN-G BEARING LIPOSOMAL AMPHOTERICIN-B SO MYCOPATHOLOGIA LA English DT Article DE FREE AMPHOTERICIN-B; IMMUNOGLOBULIN-G; LIPOSOMAL AMPHOTERICIN-B; SYSTEMIC CANDIDIASIS ID FUNGAL-INFECTIONS; CANCER-PATIENTS; ANTIBODY; CRYPTOCOCCOSIS; ALBICANS; THERAPY; MICE AB Efficacy of immunoglobulin G (IgG) bearing liposomal amphotericin B (LAMB-IgG), liposomal amphotericin B without IgG (LAMB) or free amphotericin B (fAMB/Fungizone) was investigated in the treatment of systemic candidiasis in a neutropenic mouse model. Treatment with a single dose (0.6 or 0.9 mg amphotericin B per kg body weight) of LAMB-IgG resulted in a significant increase in the survival rate of neutropenic mice infected with 3 x 10(5) cfu of Candida albicans compared to untreated controls, mice injected with IgG, or liposome alone. Survival was also better in neutropenic mice treated with LAMB-IgG than in neutropenic mice treated with the same dose of LAMB or fAMB. Moreover, 65% of all mice survived the infection after treatment with a single dose of 0.6 mg AMB of the LAMB-IgG formulation. Quantitative culture counts of organs showed that both fAMB and LABM-IgG formulations even at a dose of 0.3 mg AMB/kg, cleared C. albicans from the spleens, livers, and lungs but not from the kidneys. However, a decreasd number of C. albicans cells was recovered from the kidneys of mice that survived the infection. Results of the study suggest that LAMB-IgG is more effective than LAMB or fAMB in the therapy of disseminated candidiasis in neutropenic mice. C1 MICHIGAN STATE UNIV,DEPT BOT & PLANT PATHOL,PLANT BIOL BLDG,E LANSING,MI 48824. MICHIGAN STATE UNIV,COLL OSTEOPATH MED,E LANSING,MI 48824. MICHIGAN STATE UNIV,DEPT MICROBIOL & PUBL HLTH,E LANSING,MI 48824. MICHIGAN STATE UNIV,MED TECHNOL PROGRAM,E LANSING,MI 48824. GEORGIA STATE UNIV,DEPT CHEM,ATLANTA,GA 30303. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. NR 23 TC 5 Z9 7 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0301-486X J9 MYCOPATHOLOGIA JI Mycopathologia PD JUL PY 1993 VL 123 IS 1 BP 9 EP 17 DI 10.1007/BF01103483 PG 9 WC Mycology SC Mycology GA LZ996 UT WOS:A1993LZ99600002 PM 8247096 ER PT J AU WHITNALL, MH KISS, A AGUILERA, G AF WHITNALL, MH KISS, A AGUILERA, G TI CONTRASTING EFFECTS OF CENTRAL ALPHA-1-ADRENOCEPTOR ACTIVATION ON STRESS-RESPONSIVE AND STRESS-NONRESPONSIVE SUBPOPULATIONS OF CORTICOTROPIN-RELEASING HORMONE NEUROSECRETORY-CELLS IN THE RAT SO NEUROENDOCRINOLOGY LA English DT Article DE VASOPRESSIN; CATECHOLAMINES; ALPHA-1-ADRENERGIC RECEPTOR; MEDIAN EMINENCE; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; ACTH; METHOXAMINE; NEUROSECRETORY VESICLES; ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMISTRY ID HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; PITUITARY-ADRENOCORTICAL RESPONSES; ENHANCES VASOPRESSIN; MEDIAN-EMINENCE; IMMUNOREACTIVE INNERVATION; SYNTHESIZING NEURONS; TYROSINE-HYDROXYLASE; ARGININE VASOPRESSIN; FACTOR SECRETION; TISSUE ANTIGENS AB Stimulation of the rat hypothalamopituitary-adrenal axis during stress involves activation of central alpha1-adrenergic receptors. The subpopulation of corticotropin-releasing hormone (CRH) neurosecretory cells that contains vasopressin (VP) is selectively activated by several types of stress (immobilization, hypoglycemia, and intracerebroventricular, i.c.v., colchicine), and is located in a catecholamine-rich area of the hypothalamic paraventricular nucleus. Therefore, we tested the hypothesis that the CRH+/VP+ subpopulation is selectively activated by central alpha1-adrenergic receptors. The al-agonist methoxamine or vehicle alone was injected i.c.v. after habituation of rats to daily injections of vehicle through a chronic i.c.v. cannula. Activation of the CRH+/VP+ and CRH+/VP- subpopulations was measured by quantifying depletion of neurosecretory vesicles from immunocytochemically identified axons in the external zone of the median eminence. The habituated, vehicle-injected sham control group had normal levels of plasma ACTH and corticosterone, but possessed a significantly higher proportion of VP-containing CRH axons than naive animals. This change is similar to what was observed previously in rats subjected to repeated daily stress. I.c.v. methoxamine caused elevations of plasma ACTH and corticosterone and significant depletions of vesicles from the CRH+/VP+ axons at 1 and 2 h after injection, compared to the sham control group. The CRH+/VP- axons, however, displayed significant accumulations of neurosecretory vesicles at the same times after 300 mug methoxamine, compared to the sham control group. After 100 mug methoxamine, there was no change in the CRH+/VP- axons, compared to the sham control group. We interpret the accumulation of vesicles in the VP-deficient CRH neurosecretory axons after 300 mug i.c.v. methoxamine to reflect inhibition of this subpopulation after central alpha1-adrenergic receptor activation. The results demonstrate for the first time that central catecholamines induce release of both CRH and VP in the portal capillary plexus. These findings support the hypothesis that stress induces release of catecholamines from axons projecting to the paraventricular nucleus, thus activating alpha1-adrenergic receptors that selectively stimulate the VP-containing subpopulation of CRH neurosecretory cells. C1 NIH,INST CHILD HLTH & HUM DEV,ENDOCRINE PHYSIOL SECT,BETHESDA,MD 20892. RP WHITNALL, MH (reprint author), USA,RADIOBIOL RES INST,DEPT PHYSIOL,BETHESDA,MD 20889, USA. NR 53 TC 34 Z9 34 U1 0 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0028-3835 J9 NEUROENDOCRINOLOGY JI Neuroendocrinology PD JUL PY 1993 VL 58 IS 1 BP 42 EP 48 DI 10.1159/000126510 PG 7 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA MA162 UT WOS:A1993MA16200006 PM 8264854 ER PT J AU LAW, WA MARTIN, A SALAZAR, AM MAPOU, RL AF LAW, WA MARTIN, A SALAZAR, AM MAPOU, RL TI SYMPTOMS OF DEPRESSION IN HIV-INFECTED INDIVIDUALS - ETIOLOGIC CONSIDERATIONS SO NEUROPSYCHIATRY NEUROPSYCHOLOGY AND BEHAVIORAL NEUROLOGY LA English DT Article DE REACTION TIME; NEUROPSYCHOLOGICAL EVALUATION; INTELLECTUAL ABILITY ID HUMAN-IMMUNODEFICIENCY-VIRUS; AIDS DEMENTIA COMPLEX; MAJOR DEPRESSION; INVENTORY; MEN; MANIFESTATIONS; COMPLICATIONS; PREVALENCE; DISORDERS; DISEASE AB The relationship between self-reported symptoms of depression and reaction time were evaluated in 51 HIV seropositive (HIV+) individuals, 15 HIV seronegative (HIV-) individuals with a diagnosis of adjustment disorder, and 18 HIV- normal control subjects. The HIV+ and adjustment disorder groups had equivalent scores on the Beck Depression Inventory (BDI) that were significantly higher than the normal control group. Individual items and the group of items with somatic content were endorsed equally by the HIV+ and the psychiatric HIV- groups. A mild but significant correlation between BDI scores and reaction time was obtained only for the HIV+ group. Exploratory factor analysis of the BDI produced specific symptom clusters that correlated with reaction time in the HIV+ but not in the HIV- psychiatric subjects. These findings suggest certain self-reported symptoms of depression may reflect, at least in part, central nervous system involvement in HIV+ individuals. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PSYCHIAT,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,BETHESDA,MD 20814. NIMH,CLIN SCI LAB,BETHESDA,MD 20892. RP LAW, WA (reprint author), WALTER REED ARMY MED CTR,HENRY M JACKSON FDN ADV MIL MED,6825 16TH ST NW,WASHINGTON,DC 20307, USA. RI martin, alex/B-6176-2009 NR 44 TC 16 Z9 16 U1 1 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0894-878X J9 NEUROPSY NEUROPSY BE JI Neuropsychiatr. Neuropsychol. Behav. Neurol. PD JUL PY 1993 VL 6 IS 3 BP 181 EP 186 PG 6 WC Clinical Neurology; Psychiatry; Psychology SC Neurosciences & Neurology; Psychiatry; Psychology GA LK298 UT WOS:A1993LK29800008 ER PT J AU BOWDEN, CM AGRAWAL, GP AF BOWDEN, CM AGRAWAL, GP TI GENERALIZED BLOCH-MAXWELL FORMULATION FOR SEMICONDUCTOR-LASERS SO OPTICS COMMUNICATIONS LA English DT Article ID GAIN; SATURATION AB A perturbative method, is used, which includes, for the first time, local field effects, to obtain a set of generalized Bloch equations based upon averaging of the Bloch equations over the intraband distributions by the introduction of new dynamical variables. It is shown that the new set of Bloch equations, taken in the rate-equation limit, and neglecting local field effects, leads to the standard rate equation for the carrier density. Also is shown that the index saturates because of intraband relaxation effects, whereas the pin saturates mainly due to interband transitions. In our approach, the origin of phase-amplitude coupling, manifested through the linewidth enhancement factor, lies in the asymmetric nature of the carrier distribution within the conduction and valence bands. C1 UNIV ROCHESTER,INST OPT,ROCHESTER,NY 14627. RP BOWDEN, CM (reprint author), USA,MISSILE COMMAND,AMSMI RD WS ST RES DEV & ENGN CTR,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. RI Agrawal, Govind/D-5380-2013 OI Agrawal, Govind/0000-0003-4486-8533 NR 27 TC 23 Z9 23 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD JUL 1 PY 1993 VL 100 IS 1-4 BP 147 EP 152 DI 10.1016/0030-4018(93)90571-L PG 6 WC Optics SC Optics GA LJ527 UT WOS:A1993LJ52700026 ER PT J AU DOOLEY, DP HODGES, SD KELLY, JW AF DOOLEY, DP HODGES, SD KELLY, JW TI FACTITIOUS INFECTIONS IN ORTHOPEDIC PATIENTS SO ORTHOPEDICS LA English DT Note RP DOOLEY, DP (reprint author), BROOKE ARMY MED CTR,HSHE MDI,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD JUL PY 1993 VL 16 IS 7 BP 816 EP 820 PG 5 WC Orthopedics SC Orthopedics GA LL568 UT WOS:A1993LL56800010 PM 8361920 ER PT J AU ECKLUND, J SCHUT, L RORKE, L AF ECKLUND, J SCHUT, L RORKE, L TI ASSOCIATED VASCULAR MALFORMATIONS AND NEOPLASMS IN CHILDREN SO PEDIATRIC NEUROSURGERY LA English DT Article DE GLIOMA; NEOPLASM; CAVERNOUS ANGIOMA; ARTERIAL VENOUS MALFORMATION; ANGIOMA ID ARTERIOVENOUS MALFORMATION; COMBINED NEURILEMMOMA; OLIGODENDROGLIOMA; ANGIOGLIOMA; MENINGIOMA; ANGIOMA; GLIOMA AB Primary CNS neoplasms can rarely be associated with abnormal vascularity which is more striking than usual hypervascularity or neovascularization. These lesions are sometimes reported as angiogliomas, angiomatous astrocytomas, or descriptively as two distinct pathological entities. This vascular pattern has been reported with astrocytomas, oligodendrogliomas, neurilemmomas, meningiomas, pituitary adenomas, gangliogliomas, hemangioblastomas, mixed gliomas, gliosarcomas, and craniopharyngiomas. These lesions are classically found to be extremely vascular, both radiographically and at surgery. The true nature of these lesions is a point of controversy with some interpreting them merely as intensely vascularized tumors. Most agree, however, that unlike neovascularity in astrocytomas, the vascularity in these lesions does not carry any significant prognostic importance. In this report we present six such cases from The Children's Hospital of Philadelphia seen in the pediatric population. Four patients had vascular malformations associated with diffuse astrocytomas, and in 2 patients they were associated with subependymal giant cell astrocytomas. Five of the lesions were supratentorial, and 1 was located in the posterior fossa. The history and theories surrounding these lesions are explored. C1 CHILDRENS HOSP PHILADELPHIA,DEPT NEUROPATHOL,34TH ST & CIV CTR BLVD,PHILADELPHIA,PA 19104. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 34 TC 7 Z9 8 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1016-2291 J9 PEDIATR NEUROSURG JI Pediatr. Neurosurg. PD JUL-AUG PY 1993 VL 19 IS 4 BP 196 EP 201 DI 10.1159/000120730 PG 6 WC Clinical Neurology; Pediatrics; Surgery SC Neurosciences & Neurology; Pediatrics; Surgery GA LJ816 UT WOS:A1993LJ81600005 PM 8329304 ER PT J AU BARAFF, LJ BASS, JW FLEISHER, GR KLEIN, JO MCCRACKEN, GH POWELL, KR SCHRIGER, DL AF BARAFF, LJ BASS, JW FLEISHER, GR KLEIN, JO MCCRACKEN, GH POWELL, KR SCHRIGER, DL TI PRACTICE GUIDELINE FOR THE MANAGEMENT OF INFANTS AND CHILDREN 0 TO 36 MONTHS OF AGE WITH FEVER WITHOUT SOURCE SO PEDIATRICS LA English DT Article DE PRACTICE GUIDELINES; FEVER WITHOUT SOURCE; BACTEREMIA ID C-REACTIVE PROTEIN; SERIOUS BACTERIAL-INFECTION; ASSESSING FEBRILE CHILDREN; WHITE BLOOD-CELL; 8 WEEKS OLD; OCCULT BACTEREMIA; STREPTOCOCCUS-PNEUMONIAE; HEMOPHILUS-INFLUENZAE; OBSERVATION VARIABLES; PHYSICAL-EXAMINATION AB Study objective. To develop guidelines for the care of infants and children from birth to 36 months of age with fever without source. Participants and setting. An expert panel of senior academic faculty with expertise in pediatrics and infectious diseases or emergency medicine. Design and intervention. A comprehensive literature search was used to identify all publications pertinent to the management of the febrile child. When appropriate, meta-analysis was used to combine the results of multiple studies. One or more specific management strategies was proposed for each of decision nodes in draft management algorithms. The draft algorithms, selected publications, and the meta-analyses were provided to the panel, which determined the final guidelines using the modified Delphi technique. Results. All toxic-appearing infants and children and all febrile infants less than 28 days of age should be hospitalized for parenteral antibiotic therapy. Febrile infants 28 to 90 days of age defined at low risk by specific clinical and laboratory criteria may be managed as out-patients if close follow-up is assured. Older children with fever less than 39.0-degrees-C without source need no laboratory tests or antibiotics. Children 3 to 36 months of age with fever of 39.0-degrees-C or more and whose white blood cell count is 15 000/mm3 or more should have a blood culture and be treated with antibiotics pending culture results. Urine cultures should be obtained from all boys 6 months of age or less and all girls 2 years of age or less who are treated with antibiotics. Conclusion. These guidelines do not eliminate all risk or strictly confine antibiotic treatment to children likely to have occult bacteremia. Physicians may individualize therapy based on clinical circumstances or adopt a variation of these guidelines based on a different interpretation of the evidence. C1 TRIPLER ARMY MED CTR, HONOLULU, HI 96859 USA. CHILDRENS HOSP MED CTR, BOSTON, MA 02115 USA. BOSTON CITY HOSP, BOSTON, MA 02118 USA. UNIV TEXAS, SW MED CTR, DALLAS, TX 75230 USA. UNIV ROCHESTER, ROCHESTER, NY 14627 USA. RP BARAFF, LJ (reprint author), UNIV CALIF LOS ANGELES, CTR EMERGENCY MED, 924 WESTWOOD BLVD, SUITE 300, LOS ANGELES, CA 90024 USA. OI Schriger, David/0000-0003-0242-1127 NR 111 TC 210 Z9 224 U1 0 U2 3 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD JUL PY 1993 VL 92 IS 1 BP 1 EP 12 PG 12 WC Pediatrics SC Pediatrics GA LL160 UT WOS:A1993LL16000001 ER PT J AU NICKELS, D SCHWAB, N POTH, M AF NICKELS, D SCHWAB, N POTH, M TI EFFECTS OF SOMATOSTATIN AND CAPTOPRIL ON GLOMERULAR PROSTAGLANDIN-E(2) PRODUCTION IN NORMAL AND DIABETIC RATS SO PROSTAGLANDINS LA English DT Article ID CONVERTING ENZYME-INHIBITORS; GROWTH-HORMONE LEVELS; INITIAL RENAL GROWTH; UNINEPHRECTOMIZED RATS; URINARY-EXCRETION; MESANGIAL CELLS; SOMATOMEDIN-C; NEPHROPATHY; MELLITUS; DISEASE AB Somatostatin (SRIH) has recently been shown to be effective in reversing many of the early changes of diabetic nephropathy. It is unknown whether SRIH exerts its protective effects via its ability to suppress growth hormone (GH) or via other direct renal effects. Since changes in glomerular prostaglandin (PG) E2 production are thought to be an important part of the underlying pathophysiology of diabetic nephropathy, we sought to determine if SRIH altered glomerular PG E2 production in the rat. Whole glomeruli isolated from streptozotocin-diabetic rats and from controls were incubated with either saline, captopril, or varying concentrations of SRIH, and PG E2 production was determined by direct radioimmunoassay of media. Incubation with captopril (10(-4) M) resulted in equivalent increases in PG E2 production in glomeruli from both control and diabetic rats (140.8+/-12.8% and 150.2+/-18.9% respectively). Incubation with high concentrations of SRIH (10(-6) M) also resulted in significant increases in glomerular PG E2 production in both diabetic and control rats. However, at low SRIH concentrations (10(-10) M), glomerular PG E2 production was increased only in the diabetic rats (167.0+/-11.4% vs 95.3+/-9.2% in normals). We conclude that SRIH increases glomerular PG E2 production, and that glomeruli from diabetic rats appear to be more sensitive to lower concentrations of SRIH when compared to normal rats. It is possible that this effect on PG E2 production may underlie the favorable effects of SRIH on the glomerulus in diabetes. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP NICKELS, D (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307, USA. NR 40 TC 6 Z9 6 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN PI WOBURN PA 225 WILDWOOD AVE #UNITB PO BOX 4500, WOBURN, MA 01801-2084 SN 0090-6980 J9 PROSTAGLANDINS JI Prostaglandins PD JUL PY 1993 VL 46 IS 1 BP 61 EP 73 DI 10.1016/0090-6980(93)90063-D PG 13 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA LP952 UT WOS:A1993LP95200006 PM 8104353 ER PT J AU SALOMON, M HEFTER, GT AF SALOMON, M HEFTER, GT TI MOBILITIES OF CATION MACROCYCLIC LIGAND COMPLEXES SO PURE AND APPLIED CHEMISTRY LA English DT Article; Proceedings Paper CT INTERNATIONAL SYMP ON MACROCYCLIC LIGANDS FOR THE DESIGN OF NEW MATERIALS CY SEP 14-16, 1992 CL UNIV SURREY, GUILDFORD, ENGLAND SP INT UNION PURE & APPL CHEM, EUROPEAN COMMUNITY, INT SCI COOPERAT, USA, EUROPEAN OFF, ICI HO UNIV SURREY ID PROPYLENE CARBONATE; METAL-IONS; CONDUCTANCE; ALKALI; CONDUCTIVITY AB Formation constants for complexion between alkali metal cations and the crown ether 18C6 in the solvent 2-cyanopyridine at 30-degrees-C were determined from conductance measurements. The method allows for precise determination of these formation constants up to values of K(f) around 10(11) mol-1 dm3. The method also permits accurate evaluation of association equilibrium constants between the complex species (M-18C6)+ and the anion. The magnitudes of these ion association constants are related to the nature of the solvation of the cation and of the complexed cation. The mobilities of the complexes are also dependent, in part, upon solvation effects. In 2-cyanopyridine the single ion molar conductance of the (Li-18C6)+ complex is greater than that of the uncomplexed cation. Similar behavior is observed for alkali metal complexes with l8C6 and the cryptand 222 in other solvents such as propylene carbonate and propylene carbonate mixtures with dichloromethane. C1 MURDOCH UNIV,SCH MATH & PHYS SCI,MURDOCH,WA 6150,AUSTRALIA. RP SALOMON, M (reprint author), USA,ETDL,LABCOM,POWER SOURCES LAB,FT MONMOUTH,NJ 07703, USA. NR 39 TC 11 Z9 11 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0033-4545 J9 PURE APPL CHEM JI Pure Appl. Chem. PD JUL PY 1993 VL 65 IS 7 BP 1533 EP 1540 DI 10.1351/pac199365071533 PG 8 WC Chemistry, Multidisciplinary SC Chemistry GA LH988 UT WOS:A1993LH98800013 ER PT J AU PELLER, PJ HO, VB KRANSDORF, MJ AF PELLER, PJ HO, VB KRANSDORF, MJ TI EXTRAOSSEOUS TC-99M MDP UPTAKE - A PATHO-PHYSIOLOGICAL APPROACH SO RADIOGRAPHICS LA English DT Article DE GENITOURINARY SYSTEM, RADIONUCLIDE STUDIES; INFLAMMATION, RADIONUCLIDE STUDIES; PARATHYROID, HYPERPARATHYROIDISM; RADIONUCLIDE IMAGING, ARTIFACTS; RADIONUCLIDE IMAGING, IN DIAGNOSIS OF NEOPLASMS SOFT TISSUES, RADIONUCLIDE STUDIES ID SKELETAL TRACER KINETICS; CONCISE COMMUNICATION; METHYLENE DIPHOSPHONATE; PULMONARY CALCIFICATION; BONE-SCINTIGRAPHY; BLOOD-FLOW; PYROPHOSPHATE; RADIOPHARMACEUTICALS; HYPERCALCEMIA; ABNORMALITIES AB Scintigraphy with technetium-99m methylene diphosphonate (MDP) delineates a wide spectrum of nonosseous disorders. Neoplastic, hormonal, inflammatory, ischemic, traumatic, excretory, and artifactual entities demonstrate abnormal soft-tissue uptake of Tc-99m MDP. Mechanisms leading to increased extraosseous Tc-99m MDP uptake include extracellular fluid expansion, enhanced regional vascularity and permeability, and elevated tissue calcium concentration. The composition of the calcium deposition and the presence of other metallic ions (eg, iron and magnesium) are important. Soft-tissue Tc-99m MDP uptake is seen in benign (tumoral calcinosis, myositis ossificans) and malignant (sarcomas, adenocarcinomas, metastases) neoplastic entities. Hormonal disturbances in calcium metabolism, especially in hyperparathyroidism, can lead to metastatic calcification, visualized with Tc-99m MDP scintigraphy. Tissue damage from inflammation, infection, or physical trauma results in localized hyperemia, edema, or calcium (and hemosiderin) deposition based on their pathophysiologic characteristics. Urinary tract obstruction, anomalies, or dysfunction are demonstrated by Tc-99m MDP imaging. Common artifacts are related to faulty radiopharmaceutical preparation, Tc-99m MDP administration, and imaging technique. Recognition of these modes of extraskeletal Tc-99m MDP uptake can enhance the diagnostic value of bone scintigraphy. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. MADIGAN ARMY MED CTR,DEPT RADIOL,TACOMA,WA 98431. USA,INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20310. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. NR 64 TC 103 Z9 105 U1 0 U2 2 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD JUL PY 1993 VL 13 IS 4 BP 715 EP 734 PG 20 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA LM860 UT WOS:A1993LM86000001 PM 8356264 ER PT J AU KRANSDORF, MJ MEIS, JM AF KRANSDORF, MJ MEIS, JM TI EXTRASKELETAL OSSEOUS AND CARTILAGINOUS TUMORS OF THE EXTREMITIES SO RADIOGRAPHICS LA English DT Article DE CHONDROMA; EXTREMITIES, NEOPLASMS; FINGERS AND TOES, NEOPLASMS; MYOSITIS OSSIFICANS; OSTEOCHONDROMA; OSTEOSARCOMA; SARCOMA ID FIBRODYSPLASIA OSSIFICANS PROGRESSIVA; PSEUDOMALIGNANT MYOSITIS-OSSIFICANS; EXTRAOSSEOUS OSTEOGENIC-SARCOMA; SOFT-TISSUE MASSES; TERM FOLLOW-UP; SYNOVIAL OSTEOCHONDROMATOSIS; HETEROTOPIC OSSIFICATION; MYXOID CHONDROSARCOMA; BONE-FORMATION; CT APPEARANCE AB Extraskeletal osseous and cartilaginous tumors and tumorlike conditions of the extremities can often be differentiated radiologically; for those that cannot, knowledge of the spectrum of lesions will allow a suitably ordered differential diagnosis. Of the osseous lesions-myositis ossificans, fibro-osseous pseudotumor, fibrodysplasia ossificans progressiva soft-tissue osteoma, and extraskeletal osteosarcoma-all but myositis ossificans are relatively rare. Myositis ossificans has a distinct mineralization pattern that can be observed radiologically as a peripheral rim of lamellar bone. Fibro-osseous pseudotumor typically occurs in the digits of the hand and lacks the well-defined zoning pattern of myositis ossificans. The cartilaginous entities include the true tumors, soft-tissue chondroma and extraskeletal chondrosarcoma, and the tumorlike process, synovial osteochondromatosis. The tumors are relatively rare; synovial osteochondromatosis commonly affects middle-aged men, especially in the knee, and is associated with osteoarthritis. The differential diagnosis for these extraskeletal osseous and cartilaginous lesions includes soft-tissue sarcoma, benign mesenchymoma, malignant mesenchymoma (rare), calcified tophi in gout. melorheostosis (rare), pilomatricoma (rare), and tumoral calcinosis (rare). C1 ST MARYS HOSP,DEPT RADIOL,RICHMOND,VA. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. USA,INST PATHOL,DEPT SOFT TISSUE PATHOL,WASHINGTON,DC 20306. LOUISIANA STATE UNIV,MED CTR,SCH MED,DEPT PATHOL,NEW ORLEANS,LA 70112. GEORGETOWN UNIV,SCH MED,DEPT PATHOL,WASHINGTON,DC 20057. RP KRANSDORF, MJ (reprint author), USA,INST PATHOL,DEPT RADIOL PATHOL,BLDG 54,RM M-121,ALASKA & FERN ST,WASHINGTON,DC 20306, USA. NR 91 TC 118 Z9 123 U1 0 U2 2 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD JUL PY 1993 VL 13 IS 4 BP 853 EP 884 PG 32 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA LM860 UT WOS:A1993LM86000011 PM 8356273 ER PT J AU NAGEL, JR AF NAGEL, JR TI MIKE DISCOVERS A PLAGIARIST SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Letter RP NAGEL, JR (reprint author), USA,TEMPE,AZ, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU INDUSTRIAL RESEARCH INST INC PI WASHINGTON PA 1550 M ST., NW, WASHINGTON, DC 20005 SN 0895-6308 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD JUL-AUG PY 1993 VL 36 IS 4 BP 51 EP 52 PG 2 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA LK161 UT WOS:A1993LK16100019 ER PT J AU COLE, MW MCLANE, GF ECKART, DW MEYYAPPAN, M AF COLE, MW MCLANE, GF ECKART, DW MEYYAPPAN, M TI A COMPARATIVE MATERIALS STUDY OF MAGNETRON ION ETCHED GAAS USING FREON-12, SICL4 AND BCL3 SO SCANNING LA English DT Article DE MATERIAL DAMAGE; DRY ETCHING; MICROSTRUCTURE ID RESIDUAL DAMAGE; RAMAN-SCATTERING AB Etch characteristics and residual damage incurred via magnetron ion etching of GaAs using three different etch gases, namely, freon-12, SiCl4 and BCl3, at two different power levels has been studied. Transmission electron microscopy, scanning electron microscopy, Auger electron spectroscopy, and Schottky diode measurements were employed to determine the suitability of the processed surfaces for device fabrication. Lattice damage was incurred in all processing situations in the form of small dislocation loops. Samples etched in freon-12 at the highest power density exhibited the roughest surface morphology, while those etched in SiCl4 and BCl3 resulted in planar surfaces. The Schottky barrier diode characteristics, for all etch gases, degraded with increasing power density. The electrical quality of the BCl3-etched GaAs at the lowest power density was superior to that of the other etch gases at all power levels. The etched profiles Of SiCl4 and BCl3 yielded vertical sidewalls, whereas freon-12 yielded a negative undercut. The BCl3-etched GaAs surfaces were residue-free, while those of freon-12 and SiCl4 exhibited surface or sidewall contamination. Our results have demonstrated that magnetron ion etching with BCl3 yields planar residue-free surfaces with minimum material surface damage and superior electrical integrity compared with GaAs etched with freon-12 or SiCl4. C1 SCI RES ASSOCIATES INC,GLASTONBURY,CT. RP COLE, MW (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 12 TC 2 Z9 2 U1 0 U2 0 PU FAMS INC PI MAHWAH PA BOX 832, MAHWAH, NJ 07430 SN 0161-0457 J9 SCANNING JI Scanning PD JUL-AUG PY 1993 VL 15 IS 4 BP 225 EP 231 PG 7 WC Instruments & Instrumentation; Microscopy SC Instruments & Instrumentation; Microscopy GA LQ646 UT WOS:A1993LQ64600007 ER PT J AU VAUGHAN, GM PRUITT, BA AF VAUGHAN, GM PRUITT, BA TI THYROID-FUNCTION IN CRITICAL ILLNESS AND BURN INJURY SO SEMINARS IN NEPHROLOGY LA English DT Review ID SEVERE NONTHYROIDAL ILLNESS; EUTHYROID SICK SYNDROME; CHRONIC RENAL-FAILURE; TUMOR-NECROSIS-FACTOR; LOW-THYROXINE STATE; FREE FATTY-ACIDS; EQUILIBRIUM DIALYSIS; ILL PATIENTS; REVERSE T3; SERUM THYROTROPIN RP VAUGHAN, GM (reprint author), USA,INST SURG RES,INTERNAL MED BRANCH,BLDG 2653,FT SAM HOUSTON,TX 78234, USA. NR 117 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9295 J9 SEMIN NEPHROL JI Semin. Nephrol. PD JUL PY 1993 VL 13 IS 4 BP 359 EP 370 PG 12 WC Urology & Nephrology SC Urology & Nephrology GA LK541 UT WOS:A1993LK54100003 PM 8351451 ER PT J AU BUCHWALD, WR ZHAO, JH HARMATZ, M POINDEXTER, EH AF BUCHWALD, WR ZHAO, JH HARMATZ, M POINDEXTER, EH TI ELECTRON AND HOLE TRAPS IN HEAVILY COMPENSATED INGAAS/GAAS HETEROSTRUCTURES SO SOLID-STATE ELECTRONICS LA English DT Article ID MOLECULAR-BEAM EPITAXY; DIODES; HETEROJUNCTION; STATES AB A variety of junction space charge techniques have been used to investigate an MBE grown In0.083Ga0917As/GaAs, Al Schottky heterostructure, with the InGaAs layer above the critical thickness for this system. CV, IV and SIMS results suggest the top InGaAs layer to be heavily compensated and thus depleted of free carriers even under equilibrium conditions. Deep level transient spectroscopy measurements indicate an electron trap with an activation energy of 0.50 eV spatially located near the heterointerface as well as activation energies of 0.30 and 0.58 eV for defects in the bulk GaAs. Optical deep level transient spectroscopy was also used to investigate minority carrier defects in the InGaAs. It is argued that the depletion of the InGaAs layer gives junction space charge techniques a greater sensitivity for the determination of defect parameters located near the heterointerface, suggesting an improved approach for epilayer interface investigations. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP BUCHWALD, WR (reprint author), RUTGERS UNIV,DEPT ELECT & COMP ENGN,BOX 909,PISCATAWAY,NJ 08855, USA. NR 20 TC 6 Z9 6 U1 1 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD JUL PY 1993 VL 36 IS 7 BP 1077 EP 1082 DI 10.1016/0038-1101(93)90126-B PG 6 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA LF205 UT WOS:A1993LF20500020 ER PT J AU HAKIM, E AF HAKIM, E TI 1993 INTERNATIONAL-CONFERENCE ON MCMS SO SOLID STATE TECHNOLOGY LA English DT Editorial Material RP HAKIM, E (reprint author), USA,RES LAB,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PENNWELL PUBL CO SOLID STATE TECHNOLOGY OFFICE PI NASHUA PA TEN TARA BLVD 5TH FLOOR, NASHUA, NH 03062-2801 SN 0038-111X J9 SOLID STATE TECHNOL JI Solid State Technol. PD JUL PY 1993 VL 36 IS 7 BP 99 EP 100 PG 2 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA LN231 UT WOS:A1993LN23100011 ER PT J AU WATTENDORF, JM AF WATTENDORF, JM TI THE SOCIOLOGY CAPSTONE COURSE IN A PROFESSIONAL SCHOOL SO TEACHING SOCIOLOGY LA English DT Article C1 US MIL ACAD,DWIGHT DAVID EISENHOWER PROGRAM GRAD STUDIES LEADER DEV,W POINT,NY 10996. RP WATTENDORF, JM (reprint author), US MIL ACAD,DEPT BEHAV SCI & LEADERSHIP,W POINT,NY 10996, USA. NR 5 TC 4 Z9 4 U1 0 U2 0 PU AMER SOCIOLOGICAL ASSOC PI WASHINGTON PA 1722 N ST NW, WASHINGTON, DC 20036-2981 SN 0092-055X J9 TEACH SOCIOL JI Teach. Sociol. PD JUL PY 1993 VL 21 IS 3 BP 229 EP 232 DI 10.2307/1319016 PG 4 WC Education & Educational Research; Sociology SC Education & Educational Research; Sociology GA LK550 UT WOS:A1993LK55000007 ER PT J AU STILES, BG AF STILES, BG TI ACETYLCHOLINE-RECEPTOR BINDING CHARACTERISTICS OF SNAKE AND CONE SNAIL VENOM POSTSYNAPTIC NEUROTOXINS - FURTHER-STUDIES WITH A NONRADIOACTIVE ASSAY SO TOXICON LA English DT Article ID MONOCLONAL-ANTIBODIES; SYNTHETIC PEPTIDES; ALPHA-BUNGAROTOXIN; CONOTOXIN; SITE; PROTEIN; SUBUNITS; REGIONS; TOXINS AB The binding of postsynaptic neurotoxins from snake and marine cone snail (Conus sp.) venoms to nicotinic acetylcholine receptor (AchR) was investigated with an ELISA-based, non-radioactive assay. Three snake postsynaptic toxins from the long-chain group (Naja naja kaouthia cobratoxin, Naja oxiana neurotoxin I, Bungarus multicinctus alpha-bungarotoxin) and short-chain group (Naja naja atra cobrotoxin, Naja oxiana neurotoxin II, and Laticauda semifasciata erabutoxin b) were studied. Both types of snake postsynaptic toxins showed a dose-response with constant AchR (50 mug/ml) and varying toxin concentrations (50-0.035 mug/ml). The minimum detection limits of the assay for snake toxins ranged from 310 to 1240 ng/ml (40-160 pmole/ml), depending on the toxin. Unlike any of the short-chain toxins, long-chain toxins consistently bound less receptor and reached maximum absorbance levels with toxin concentrations of 10-50 mug/ml. Competition for AchR binding between cone snail postsynaptic neurotoxins (conotoxins GI, MI, SI) and alpha-bungarotoxin or cobrotoxin resulted in a dose-response. The postsynaptic conotoxins were uniformly better competitors for AchR binding with alpha-bungarotoxin than with cobrotoxin. Heat stability studies with neurotoxin I, erabutoxin b, or cobrotoxin revealed a loss in AchR binding activity with increasing temperature. Alpha-Bungarotoxin heated at 90-degrees-C had increased AchR binding activity by 105%, relative to 25-degrees-C samples, but lost the majority of its binding activity after 100-degrees-C. The enhanced binding of heated alpha-bungarotoxin to AchR was specific, as evidenced by a competitive dose-response with unheated a-bungarotoxin, but heated toxin lacked any biological activity in the mouse lethal assay. When conotoxins GI or MI were heated at 100-degrees-C, there was no detectable loss in AchR binding activity, and only a slight decrease in mouse lethality. RP STILES, BG (reprint author), USA,MED RES INST INFECT DIS,DIV TOXINOL,FT DETRICK,MD 21702, USA. NR 30 TC 9 Z9 9 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD JUL PY 1993 VL 31 IS 7 BP 825 EP 834 DI 10.1016/0041-0101(93)90217-7 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA LN860 UT WOS:A1993LN86000001 PM 8212028 ER PT J AU HINES, HB NASEEM, SM WANNEMACHER, RW AF HINES, HB NASEEM, SM WANNEMACHER, RW TI [H-3] SAXITOXINOL METABOLISM AND ELIMINATION IN THE RAT SO TOXICON LA English DT Note ID SHELLFISH AB Tritiated saxitoxinol was used to obtain preliminary information on saxitoxin metabolism in the rat. Sublethal doses of tritiated saxitoxinol (18.9-muCi/kg; 3.8 mug/kg) were injected i.v. into each of six rats. Urine and fecal samples were collected up to 144 hr post-injection. Within 4 hr, 60% of injected radioactivity was excreted in urine. No radioactivity was found in feces. High performance liquid chromatography analyses of urine showed that saxitoxinol was not metabolized by the rats. RP HINES, HB (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FT DETRICK,MD 21701, USA. NR 7 TC 22 Z9 24 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD JUL PY 1993 VL 31 IS 7 BP 905 EP 908 DI 10.1016/0041-0101(93)90226-9 PG 4 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA LN860 UT WOS:A1993LN86000010 PM 8212035 ER PT J AU SPIRNAK, JP LUBKE, WL THOMPSON, IM LOPEZ, M AF SPIRNAK, JP LUBKE, WL THOMPSON, IM LOPEZ, M TI DYSTROPHIC BLADDER WALL CALCIFICATIONS FOLLOWING INTRAVESICAL BCG TREATMENT FOR SUPERFICIAL TRANSITIONAL-CELL CARCINOMA OF BLADDER SO UROLOGY LA English DT Note ID BACILLUS CALMETTE-GUERIN; MITOMYCIN-C TREATMENT; CANCER; INSITU AB Bacillus Calmette-Guerin has been established as one of the most active agents for the treatment of superficial transitional cell carcinoma of the bladder. Although complications do occur with this agent, they are usually transient and mild. Two cases are herein reported in which dystrophic calcification of the urinary bladder occurred following BCG therapy; one had a diffuse and severe complication. This complication can occur with other intravesical agents, and methods for management are reported. C1 BROOKE ARMY MED CTR,DEPT UROL,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234. WILFORD HALL USAF MED CTR,DEPT UROL,SAN ANTONIO,TX. RP SPIRNAK, JP (reprint author), BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234, USA. NR 15 TC 6 Z9 7 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD JUL PY 1993 VL 42 IS 1 BP 89 EP 92 DI 10.1016/0090-4295(93)90350-J PG 4 WC Urology & Nephrology SC Urology & Nephrology GA LR144 UT WOS:A1993LR14400018 PM 8328131 ER PT J AU BURKE, DS AF BURKE, DS TI VACCINE THERAPY FOR HIV - A HISTORICAL REVIEW OF THE TREATMENT OF INFECTIOUS-DISEASES BY ACTIVE SPECIFIC IMMUNIZATION WITH MICROBE-DERIVED ANTIGENS SO VACCINE LA English DT Review DE VACCINE THERAPY; VACCINE; AIDS HIV; MICROBE-DERIVED ANTIGENS ID RECURRENT GENITAL HERPES; TUMOR-CELL VACCINE; LOCALIZED CUTANEOUS LEISHMANIASIS; COLORECTAL-CANCER PATIENTS; MITSUDA-NEGATIVE CONTACTS; MYCOBACTERIUM-LEPRAE; GUINEA-PIGS; GLYCOPROTEIN IMMUNOTHERAPY; PULMONARY TUBERCULOSIS; LEPROSY PATIENTS AB A review of the history of 'vaccine therapy' for infectious diseases is presented. The concept originated when Auzias-Turenne introduced 'syphilitic vaccination' or 'syphilization' as a treatment for syphilis in Paris in the mid-1800s; his clinical studies probably influenced Pasteur's successful rabies postexposure vaccine trials. Robert Koch in Berlin in the 1890s observed that inoculation of tuberculin into patients with tuberculosis induced an inflammatory response in affected tissues, and advocated 'tuberculin therapy. Sir Almroth Wright in London in the early 20th century devised methods to measure changes in serum 'opsonizing' activity in response to therapeutic inoculations with microbe-derived vaccines. Since the advent of antibiotics, active specific immunization with microbe-derived antigens (vaccine therapy) has been largely forgotten as a strategy for treatment of infectious diseases. Advances in antigen production and in molecular immunology now permit new tactics to probe, analyse and selectively alter in vivo human immune responses to infectious microbes. Our recent demonstration that vaccine therapy can boost natural immunity to HIV in infected patients should rekindle interest in this approach. RP BURKE, DS (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,13 TAFT COURT,SUITE 201,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 133 TC 23 Z9 23 U1 0 U2 4 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD JUL PY 1993 VL 11 IS 9 BP 883 EP 891 DI 10.1016/0264-410X(93)90374-7 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA LM707 UT WOS:A1993LM70700001 PM 8212833 ER PT J AU DEZZUTTI, CS RUDOLPH, DL ROBERTS, CR LAL, RB AF DEZZUTTI, CS RUDOLPH, DL ROBERTS, CR LAL, RB TI CHARACTERIZATION OF HUMAN T-LYMPHOTROPIC VIRUS TYPE I-INFECTED AND II-INFECTED T-CELL LINES - ANTIGENIC, PHENOTYPIC, AND GENOTYPIC ANALYSIS SO VIRUS RESEARCH LA English DT Article DE HUMAN T-LYMPHOTROPIC VIRUS; HTLV; T-CELL LINE; GENOTYPE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM ID TROPICAL SPASTIC PARAPARESIS; LONG TERMINAL REPEATS; HTLV-I; LEUKEMIA-VIRUS; PERIPHERAL-BLOOD; AFRICAN PATIENTS; UNITED-STATES; LYMPHOMA; IMMORTALIZATION; EXPRESSION AB Eighteen long-term T-cell lines were established from peripheral blood mononuclear cells of individuals infected with human T-lymphotropic virus type I (HTLV-I) or II (HTLV-II). These cell lines (10 HTLV-I and 8 HTLV-11), representing diverse pathologic profiles and geographic regions, have been in culture for over 6 months and have constitutively produced p24gag antigen. Antigenic characterization of the cell lines by Western blot analysis demonstrated that all but one produced gag (p24) and env (gp46 or gp52) structural proteins; one HTLV-I-infected cell line exhibited an aberrant protein profile. Phenotypic analysis of the HTLV-infected cell lines demonstrated phenotypes consistent with activated T-cells (CD5+, CD25+, HLA-DR+). The HTLV-I-infected cell lines were predominantly CD4+ (IR, FS, A212, SP, 1657, 1742, 3669, 1996, and 3614), whereas EG was CD8+. The HTLV-II-infected cell lines were either CD4+ (H2A, Y17, G12.1), CD8+ (H1H, H2E, Y03, Y06), or both (H1B). Restriction map analysis and subtyping of the viral genomes demonstrated heterogeneity among these isolates. Of the HTLV-I-infected cell lines, six were subtype II, one was subtype III and, on the basis of additional restriction sites, another subtype, tentatively classified as subtype IV, could he identified for three of the HTLV-I-infected cell lines. Of the HTLV-II-infected cell lines, six were subtype HTLV-IIa and two were subtype HTLV-IIb. While the majority of the cell lines resemble the prototypic HTLV-I-infected (MT-2) and HTLV-II-infected (MoT) cell lines, the antigenic, phenotypic, and genotypic data collectively demonstrate heterogeneity among viral isolates representing diverse geographic regions. C1 WALTER REED ARMY INST RES,DIV DIAGN VIROL,WASHINGTON,DC. RP DEZZUTTI, CS (reprint author), CTR DIS CONTROL & PREVENT,NAT CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,RETROVIRUS DIS BRANCH,ATLANTA,GA 30333, USA. NR 29 TC 20 Z9 21 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD JUL PY 1993 VL 29 IS 1 BP 59 EP 70 DI 10.1016/0168-1702(93)90125-7 PG 12 WC Virology SC Virology GA LQ240 UT WOS:A1993LQ24000005 PM 8105609 ER PT J AU STURM, M HOLMGREN, J AF STURM, M HOLMGREN, J TI RAIN-INDUCED WATER PERCOLATION IN SNOW AS DETECTED USING HEAT-FLUX TRANSDUCERS SO WATER RESOURCES RESEARCH LA English DT Article ID MELTWATER MOVEMENT; SIERRA-NEVADA; SNOWPACKS; COVER AB The percolation of water through snow is shown to be detectable with heat flux transducers (HFTs) at the base of, or embedded within, the snow. Theory indicates that the arrival of water at a HFT will result in a rapid drop in heat flow to negative values, followed by an exponential rise. Laboratory and field tests verify that the theory correctly predicts the form of the signal, and consideration of conditions in a snow cover suggest that it is unlikely the signal can be generated in any other way. Large (15 x 15 cm) HFTs were installed at the snow/ground interface at three locations in Alaska where rain on snow is common. During three winters, heat flux signals indicative of water percolating to the base of the snow were detected 23 times, often simultaneously at two or more sites. All signals were coincident with rain-on-snow events, though not all rain-on-snow events (there were a total of 27) were associated with distinctive heat flux signals. Signals were observed only when rainfall rates exceeded 1.5 cm d-1, and the character of the signal differed if the snow/ground interface was at or lower than 0-degrees-C. Observed delays between the start of rain and the arrival of water at the base of the snow ranged between 2 and 40 hours. A geometric analysis was used to calculate the spacing of percolation fingers or columns necessary to produce the observed number of times that water percolated onto the HFTs. The number of times there were abrupt changes in the temperature of thermistors installed in the snow adjacent to the HFTs was used in a similar manner. Results from both analyses suggest percolation columns with a mean spacing of about 25 cm, which is consistent with observations of these features in snow trenches. RP STURM, M (reprint author), USA,COLD REG RES & ENGN LAB,ALASKA PROJECTS OFF,BLDG 4070,FT WAINWRIGHT,AK 99703, USA. NR 27 TC 9 Z9 9 U1 0 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD JUL PY 1993 VL 29 IS 7 BP 2323 EP 2334 DI 10.1029/93WR00609 PG 12 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA LL335 UT WOS:A1993LL33500039 ER PT J AU BOLAN, CD KRISHNAMURTI, C TANG, DB CARRINGTON, LR ALVING, BM AF BOLAN, CD KRISHNAMURTI, C TANG, DB CARRINGTON, LR ALVING, BM TI FUNCTIONAL PROTEIN-S DEFICIENCY IN A KINDRED WITH THROMBOSIS PREVIOUSLY ATTRIBUTED TO ELEVATED LEVELS OF PLASMINOGEN-ACTIVATOR INHIBITOR-1 SO THROMBOSIS AND HAEMOSTASIS LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD JUN 30 PY 1993 VL 69 IS 6 BP 576 EP 576 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA LT577 UT WOS:A1993LT57700118 ER PT J AU KRISHNAMURTI, C BOLAN, CD COLLETON, CA REILLY, TM ALVING, BM AF KRISHNAMURTI, C BOLAN, CD COLLETON, CA REILLY, TM ALVING, BM TI COMPARISON OF THE THROMBOGENIC EFFECTS OF ANCROD AND THROMBIN ON RENAL FIBRIN DEPOSITION IN RABBITS WITH ELEVATED LEVELS OF PLASMINOGEN-ACTIVATOR INHIBITOR (PAI-1) SO THROMBOSIS AND HAEMOSTASIS LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. DUPONT MERCK CO,WILMINGTON,DE. NR 0 TC 0 Z9 0 U1 0 U2 0 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD JUN 30 PY 1993 VL 69 IS 6 BP 590 EP 590 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA LT577 UT WOS:A1993LT57700163 ER PT J AU REID, TJ ALVING, BM AF REID, TJ ALVING, BM TI THE QUANTITATIVE THROMBIN TIME (QTT) - A SIMPLE, RAPID METHOD FOR MONITORING LEVELS OF HIRULOG(TM) OR R-HIRUDIN IN PATIENT PLASMAS OR WHOLE-BLOOD SO THROMBOSIS AND HAEMOSTASIS LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 1 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD JUN 30 PY 1993 VL 69 IS 6 BP 1306 EP 1306 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA LT577 UT WOS:A1993LT57702731 ER PT J AU ALESSIO, M GRECO, NJ OCKENHOUSE, CF TANDON, NN JAMIESON, GA MALAVASI, F AF ALESSIO, M GRECO, NJ OCKENHOUSE, CF TANDON, NN JAMIESON, GA MALAVASI, F TI THE ANTI-CD36 IGM MOAB NL07 RECOGNIZES A SIMILAR EPITOPE TO THE IGG OKM-5 AND INDUCES COMPLEMENT-DEPENDENT PLATELET ACTIVATION INDEPENDENT OF GPIIB/IIIA SO THROMBOSIS AND HAEMOSTASIS LA English DT Meeting Abstract C1 OSPED SAN RAFFAELE,DIBIT,MILAN,ITALY. AMER RED CROSS,DEPT CELL BIOL,ROCKVILLE,MD. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV TURIN,BIOL CELLULARE LAB,I-10124 TURIN,ITALY. NR 1 TC 0 Z9 0 U1 0 U2 0 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD JUN 30 PY 1993 VL 69 IS 6 BP 1343 EP 1343 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA LT577 UT WOS:A1993LT57702870 ER PT J AU HAMMER, CU MEESE, DA AF HAMMER, CU MEESE, DA TI DATING ICE CORES SO NATURE LA English DT Letter C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP HAMMER, CU (reprint author), UNIV COPENHAGEN,NIELS BOHR INST PHYS ASTRON & GEOPHYS,DK-2200 COPENHAGEN,DENMARK. NR 3 TC 8 Z9 8 U1 2 U2 5 PU MACMILLAN MAGAZINES LTD PI LONDON PA PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW SN 0028-0836 J9 NATURE JI Nature PD JUN 24 PY 1993 VL 363 IS 6431 BP 666 EP 666 DI 10.1038/363666g0 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA LJ339 UT WOS:A1993LJ33900021 ER PT J AU KNIGHT, RD PARSHAD, R PRICE, FM TARONE, RE SANFORD, KK AF KNIGHT, RD PARSHAD, R PRICE, FM TARONE, RE SANFORD, KK TI X-RAY-INDUCED CHROMATID DAMAGE IN RELATION TO DNA-REPAIR AND CANCER INCIDENCE IN FAMILY MEMBERS SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article ID CELL-CYCLE PERIOD; ATAXIA-TELANGIECTASIA; CHROMOSOMAL RADIOSENSITIVITY; G2; IRRADIATION; ABERRATIONS; LYMPHOCYTES; SENSITIVITY AB The cytogenetic response to G2-phase X-irradiation was examined in phytohemagglutinin-stimulated peripheral-blood lymphocytes from 69 individuals, a few of whom were cancer patients. The cancer patients had not received radiation or chemotherapy. The responses of cells arrested by Colcemid 30 to 90 min after X-irradiation (58R) could be divided into 2 distinct categories: 51 individuals had aberration frequencies typical of normal individuals in previous studies, while 18 others had a 2- to 3-fold higher frequency of chromatid breaks and gaps. Because chromatid breaks and gaps result from unrepaired DNA strand breaks, the first category may represent an efficient DNA repair phenotype, while the second may represent a deficient repair phenotype. The individuals with the deficient G2 response reported having first- and second-degree relatives with a 3.6- and 2.2-fold higher mean frequency of cancer, respectively. The present results, together with those from earlier studies of families with a genetic disorder predisposing to cancer, suggest that this deficient cytogenetic response to G2 phase X-irradiation is associated with a high risk of cancer. (C) 1993 Wiley-Liss, Inc. C1 NCI,CELLULAR & MOLEC BIOL LAB,BLDG 37,RM 2015,BETHESDA,MD 20892. NCI,BIOSTAT BRANCH,BETHESDA,MD 20892. WALTER REED ARMY INST RES,DIV HEMATOL,WASHINGTON,DC 20307. HOWARD UNIV,COLL MED,DEPT PATHOL,WASHINGTON,DC 20059. NR 23 TC 62 Z9 63 U1 1 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0020-7136 J9 INT J CANCER JI Int. J. Cancer PD JUN 19 PY 1993 VL 54 IS 4 BP 589 EP 593 DI 10.1002/ijc.2910540412 PG 5 WC Oncology SC Oncology GA LJ491 UT WOS:A1993LJ49100011 PM 8514450 ER PT J AU POINDEXTER, EH RONG, FC BUCHWALD, WR GERARDI, GJ KEEBLE, DJ WARREN, WL AF POINDEXTER, EH RONG, FC BUCHWALD, WR GERARDI, GJ KEEBLE, DJ WARREN, WL TI ELECTRICALLY-DETECTED MAGNETIC-RESONANCE NEAR THE P-DOPED N-DOPED INTERFACE OF SI JUNCTION DIODES SO COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS LA English DT Article; Proceedings Paper CT 6TH INTERNATIONAL SYMP ON MAGNETIC RESONANCE IN COLLOID AND INTERFACE SCIENCE CY JUN 22-26, 1992 CL FLORENCE, ITALY SP COMMISS EUROPEAN COMMUNITIES, CNR, AZIENDA PROMOZ TURIST FIRENZE, BANCA COMMERCIALE ITALIANA, BRUKER ANAL MESSTECH, BRUCKER SPECTROSPIN ITALIANA, COMUNE FIRENZE, DITTA VANNI PICCINOTTI, ELSEVIER, EUROPEAN COLLOID & INTERFACE SOC DE ELECTRICALLY-DETECTED MAGNETIC RESONANCE; SILICON JUNCTION DIODES ID SPIN-DEPENDENT RECOMBINATION; SILICON; PLATINUM; SEMICONDUCTORS; IRRADIATION; SI/SIO2; CAPTURE AB Hyperfine structure has beep observed in the electrically-detected magnetic resonance signal from a silicon p-n junction diode. By comparing the g value, hyperfine parameters, and bandgap energy level with known species having suitable abundances of isotopes with I = 1/2, the center is tentatively assigned as a platinum moiety, of presently undetermined structure. The observation indicates the usefulness of EDMR in the study of defects in ultrasmall Si devices, and raises certain questions regarding the current theories of spin-dependent recombination. C1 WILLIAM PATERSON COLL NEW JERSEY,DEPT CHEM,WAYNE,NJ 07470. MICHIGAN TECHNOL UNIV,DEPT PHYS,HOUGHTON,MI 49931. SANDIA NATL LABS,ALBUQUERQUE,NM 87185. RP POINDEXTER, EH (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. RI Keeble, David /C-6633-2012 OI Keeble, David /0000-0002-5378-799X NR 31 TC 0 Z9 0 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-7757 J9 COLLOID SURFACE A JI Colloid Surf. A-Physicochem. Eng. Asp. PD JUN 17 PY 1993 VL 72 BP 119 EP 125 DI 10.1016/0927-7757(93)80458-Q PG 7 WC Chemistry, Physical SC Chemistry GA LK993 UT WOS:A1993LK99300015 ER PT J AU GERARDI, GJ RONG, FC POINDEXTER, EH HARMATZ, M SHEN, H WARREN, WL AF GERARDI, GJ RONG, FC POINDEXTER, EH HARMATZ, M SHEN, H WARREN, WL TI STUDY OF A PARAMAGNETIC CENTER ON AN SIO-TREATED GAAS SURFACE SO COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS LA English DT Article; Proceedings Paper CT 6TH INTERNATIONAL SYMP ON MAGNETIC RESONANCE IN COLLOID AND INTERFACE SCIENCE CY JUN 22-26, 1992 CL FLORENCE, ITALY SP COMMISS EUROPEAN COMMUNITIES, CNR, AZIENDA PROMOZ TURIST FIRENZE, BANCA COMMERCIALE ITALIANA, BRUKER ANAL MESSTECH, BRUCKER SPECTROSPIN ITALIANA, COMUNE FIRENZE, DITTA VANNI PICCINOTTI, ELSEVIER, EUROPEAN COLLOID & INTERFACE SOC DE ELECTRON PARAMAGNETIC RESONANCE; GAAS; PHOTOLUMINESCENCE; SIO ID REAL-TIME; PASSIVATION; HYDROGEN; ENHANCEMENT AB We have observed enhanced photoluminescence and an isotropic, singlet electron paramagnetic resonance (EPR) signal from samples of SI c-GaAs as a result of a thermal annealing treatment with SiO under vacuum. The treated samples showed a tenfold increase in photoluminescence. The EPR signal was detected at room temperature and was found to have a g value of 2.0017 and a linewidth of 0.1 mT. The enhanced photoluminescence and the EPR signal were both quenched by a 10 min exposure to hydrogen plasma with the sample near room temperature. Chemical and spectroscopic evidence indicates that the resonance is due to a silicon-related center near the GaAs surface. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. SANDIA NATL LABS,ALBUQUERQUE,NM 87185. RP GERARDI, GJ (reprint author), WILLIAM PATERSON COLL NEW JERSEY,DEPT CHEM,WAYNE,NJ 07470, USA. RI Schaff, William/B-5839-2009 NR 14 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-7757 J9 COLLOID SURFACE A JI Colloid Surf. A-Physicochem. Eng. Asp. PD JUN 17 PY 1993 VL 72 BP 161 EP 164 DI 10.1016/0927-7757(93)80462-N PG 4 WC Chemistry, Physical SC Chemistry GA LK993 UT WOS:A1993LK99300019 ER PT J AU SHIH, A COWAN, PL SOUTHWORTH, S FOTIADIS, L HOR, C KARLIN, B MOORE, F DOBISZ, E DIETRICH, H AF SHIH, A COWAN, PL SOUTHWORTH, S FOTIADIS, L HOR, C KARLIN, B MOORE, F DOBISZ, E DIETRICH, H TI LATTICE POSITION OF SI IN GAAS DETERMINED BY X-RAY STANDING-WAVE MEASUREMENTS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SYNCHROTRON RADIATION BEAMLINE; HIGH-ENERGY-RESOLUTION; SILICON; IMPLANTATION; DIFFUSION AB The x-ray standing wave (XSW) technique was applied to determine the lattice location of Si impurity atoms in GaAs(100) crystals. The synchrotron radiation of X24A at the national synchrotron light source was utilized to set up backreflection XSW, an experimental geometry which drastically relaxes the otherwise stringent requirement on the lattice perfection. Specifically, the lattice sites were determined with respect to the [311] reflection planes which differentiate a Ga site from an As site. With the aid of an appropriate choice of the x-ray fluorescence filter, we were able to study GaAs(100) samples with very low levels of Si impurities. On a sample doped with 4 X 10(18) cm-3 Si during the molecular-beam epitaxy growth, we found that the Si atoms predominantly occupied the Ga sites. On both an ion-implanted sample after annealing and a sample with Si impurities introduced by thermal diffusion, about 30% of the Si atoms occupied the Ga sites, and the rest occupied random sites. The As site occupation was less than 6%. Suggestions are made for further experiments with improved sensitivity. C1 NATL INST STAND & TECHNOL,GAITHERSBURG,MD. USA,ELECTR COMMAND,FT MONMOUTH,NJ 07703. BROOKHAVEN NATL LAB,NATL SYNCHROTRON LIGHT SOURCE,UPTON,NY 11973. WHITMAN COLL,DEPT PHYS,WALLA WALLA,WA 99362. RP SHIH, A (reprint author), USN,RES LAB,WASHINGTON,DC 20375, USA. NR 24 TC 1 Z9 1 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 15 PY 1993 VL 73 IS 12 BP 8161 EP 8168 DI 10.1063/1.353430 PG 8 WC Physics, Applied SC Physics GA LH229 UT WOS:A1993LH22900021 ER PT J AU ZAVADA, JM VOILLOT, F LAURET, N WILSON, RG THEYS, B AF ZAVADA, JM VOILLOT, F LAURET, N WILSON, RG THEYS, B TI CHARACTERIZATION OF HYDROGENATED GAAS/ALGAAS MULTIPLE-QUANTUM-WELL STRUCTURES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID PHOTOLUMINESCENCE; DONORS AB We report on the photoluminescence properties and the hydrogen depth distributions of plasma treated GaAs/AlGaAs multiple quantum well (MQW) structures. Specimens grown by molecular beam epitaxy were exposed to a deuterium plasma under different temperature-time conditions. Photoluminescence measurements were made at 4.2 K, using low and high excitation powers, on the hydrogenated samples and on untreated partners. A decrease in the linewidth of the free exciton and an increase in the peak intensity were observed in specimens following plasma treatment. In general, each of the hydrogenated MQW specimens displayed an increase in luminescence efficiency and a diminution of impurity-related peaks after hydrogenation. Secondary ion mass spectrometry measurements yielded depth distributions for H-2 and Al atoms. In samples having the best luminescence, the H-2 was nearly constant throughout the MQW region, at about 10(18) cm-3. C1 INST NATL SCI APPL,F-31077 TOULOUSE,FRANCE. HUGHES RES LABS,MALIBU,CA 90265. CNRS,PHYS SOLIDES LAB,F-92195 MEUDON,FRANCE. RP ZAVADA, JM (reprint author), USA,RES OFF,RES TRIANGLE PK,NC 27709, USA. RI Schaff, William/B-5839-2009 NR 13 TC 9 Z9 9 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 15 PY 1993 VL 73 IS 12 BP 8489 EP 8494 DI 10.1063/1.353401 PG 6 WC Physics, Applied SC Physics GA LH229 UT WOS:A1993LH22900071 ER PT J AU ANDERSON, RJ SHARP, EJ WOOD, GL CLARK, WW VUONG, QC SALAMO, GJ NEURGAONKAR, RR AF ANDERSON, RJ SHARP, EJ WOOD, GL CLARK, WW VUONG, QC SALAMO, GJ NEURGAONKAR, RR TI MUTUALLY PUMPED PHASE CONJUGATOR AS A MOVING-OBJECT CORRELATOR SO OPTICS LETTERS LA English DT Article ID FILTERS; BATIO3 AB Cross talk is observed in a photorefractive bridge mutually pumped phase conjugator during the transient time of photorefractive grating formation and is utilized to construct a moving-object correlator. The correlation of various input images has been demonstrated and compared with calculated results. The device is currently capable of a resolution of approximately 4 to 6 lines/mm. C1 USA,RES LAB,FT BELVOIR,VA 22060. UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701. ROCKWELL INT SCI CTR,THOUSAND OAKS,CA 91360. RP ANDERSON, RJ (reprint author), NATL SCI FDN,WASHINGTON,DC 20550, USA. NR 15 TC 14 Z9 14 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD JUN 15 PY 1993 VL 18 IS 12 BP 986 EP 988 DI 10.1364/OL.18.000986 PG 3 WC Optics SC Optics GA LF889 UT WOS:A1993LF88900018 PM 19823267 ER PT J AU ATHALE, RA RAJ, K SAVKAR, VA AF ATHALE, RA RAJ, K SAVKAR, VA TI FULLY PARALLEL ANALOG OPTICAL CALCULATION OF MULTIPLE OUTER PRODUCTS SO OPTICS LETTERS LA English DT Article ID MATRIX; SYSTEM; MULTIPLICATION AB An analog optical processor for evaluating weighted sums of outer products in parallel is described. It uses a linear array of light sources oriented along the diagonal, two-dimensional spatial light modulators to encode input vectors, a two-dimensional detector array to generate the output, and conventional spherical and cylindrical lenses. This system can be used to multiply two matrices as well as to evaluate a weighted rank-1 synthesis of images in a single clock cycle of the processor. Initial experimental results are presented, and factors limiting the performance are described. Implications of this architecture to optical signal- and image-processing systems are discussed. C1 GEORGE MASON UNIV,DEPT ELECT & COMP ENGN,FAIRFAX,VA 22030. RP ATHALE, RA (reprint author), USA,RES LABS,OPT SIGNAL PROC GRP,ADELPHI,MD 20783, USA. NR 12 TC 7 Z9 7 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD JUN 15 PY 1993 VL 18 IS 12 BP 989 EP 991 DI 10.1364/OL.18.000989 PG 3 WC Optics SC Optics GA LF889 UT WOS:A1993LF88900019 PM 19823268 ER PT J AU CHAN, MMY GROGL, M CHEN, CC BIENEN, EJ FONG, D AF CHAN, MMY GROGL, M CHEN, CC BIENEN, EJ FONG, D TI HERBICIDES TO CURB HUMAN PARASITIC INFECTIONS - INVITRO AND INVIVO EFFECTS OF TRIFLURALIN ON THE TRYPANOSOMATID PROTOZOANS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE LEISHMANIA; TRYPANOSOMA; MICROTUBULE; DINITROANILINE ID LEISHMANIA-MEXICANA; BETA-TUBULIN; DINITROANILINE HERBICIDES; CUTANEOUS LEISHMANIASIS; TOPICAL TREATMENT; DIFFERENTIATION; BIOSYNTHESIS; EXPRESSION; PROTEIN; ALPHA AB Leishmaniasis is a major tropical disease for which current chemotherapies, pentavalent antimonials, are inadequate and cause severe side effects. It has been reported that trifluralin, a microtubule-disrupting herbicide, is inhibitory to Leishmania amazonensis. In this study, the in vitro effect of trifluralin on different species of trypanosomatid protozoans was determined. In addition to L. amazonensis, trifluralin is effective against Leishmania major and Leishmania tropica, which cause cutaneous infections, Leishmania donovani, which causes visceral disease, Leishmania panamensis, which may cause mucocutaneous infection, and Trypanosoma brucei, an important human and veterinary pathogen. Moreover, most encouragingly, trifluralin is effective in vivo as a topical ointment against L. major and Leishmania mexicana murine cutaneous leishmaniasis. Thus, trifluralin is a promising lead drug for several related, prevalent tropical diseases: leishmaniasis, trypanosomiasis of animals, and, possibly, African trypanosomiasis in humans. C1 RUTGERS UNIV,BUR BIOL RES,PISCATAWAY,NJ 08855. WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NYU,SCH MED,DEPT MED & MOLEC PARASITOL,NEW YORK,NY 10016. RP CHAN, MMY (reprint author), RUTGERS UNIV,DEPT BIOL SCI,PISCATAWAY,NJ 08855, USA. FU NCI NIH HHS [CA 49359]; NIAID NIH HHS [R01 AI 17899] NR 38 TC 56 Z9 56 U1 0 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUN 15 PY 1993 VL 90 IS 12 BP 5657 EP 5661 DI 10.1073/pnas.90.12.5657 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA LH129 UT WOS:A1993LH12900059 PM 8516314 ER PT J AU KRASKO, GL AF KRASKO, GL TI SITE COMPETITION EFFECT OF IMPURITIES AND GRAIN-BOUNDARY STABILITY IN IRON AND TUNGSTEN SO SCRIPTA METALLURGICA ET MATERIALIA LA English DT Article ID SEGREGATION; CARBON; SULFUR; BORON; EMBRITTLEMENT; TEMPERATURE; PHOSPHORUS; COHESION; METALS RP KRASKO, GL (reprint author), USA,RES LAB,MAT DIRECTORATE,WATERTOWN,MA 02172, USA. NR 35 TC 26 Z9 26 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0956-716X J9 SCRIPTA METALL MATER JI Scr. Metall. Materialia PD JUN 15 PY 1993 VL 28 IS 12 BP 1543 EP 1548 DI 10.1016/0956-716X(93)90589-K PG 6 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA LB622 UT WOS:A1993LB62200015 ER PT J AU TUMOLILLO, TA ASHLEY, PR AF TUMOLILLO, TA ASHLEY, PR TI MULTILEVEL REGISTERED POLYMERIC MACH-ZEHNDER INTENSITY MODULATOR ARRAY SO APPLIED PHYSICS LETTERS LA English DT Article AB Described here is the first known demonstration of a registered two level guided wave polymeric electro-optic Mach-Zehnder intensity modulator array. The device consists of two complete vertically stacked levels. Both levels were independently poled and operated. There was no measurable optical or electrical cross talk due to a high resistivity thermoset polymer buffers layer employed. Fabrication and performance of the device is discussed. RP TUMOLILLO, TA (reprint author), USA MISSILE COMMAND,AMSMI RD WS CM,CTR RES DEV & ENGN,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 14 TC 43 Z9 44 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 14 PY 1993 VL 62 IS 24 BP 3068 EP 3070 DI 10.1063/1.109137 PG 3 WC Physics, Applied SC Physics GA LF990 UT WOS:A1993LF99000002 ER PT J AU RAJ, K PRATHER, DW ATHALE, RA MAIT, JN AF RAJ, K PRATHER, DW ATHALE, RA MAIT, JN TI PERFORMANCE ANALYSIS OF OPTICAL SHADOW-CASTING CORRELATORS SO APPLIED OPTICS LA English DT Article AB We analyze the performance of two optical shadow-casting image correlators that use two-dimensional source arrays to encode the system point-spread function (PSF). The analysis of a standard shadow-casting correlator suggests that the angular divergence of the source array is a critical parameter in the determination of the maximum space-bandwidth product of the image and of the PSF that can be used with such a system. Further, the energy efficiency of a standard shadow-casting correlator is related inversely to the size of the PSF. We show that the constraints on energy efficiency and on the space-bandwidth product of the PSF can be overcome by beam steering the source elements. A modified shadow-casting correlator is proposed that uses phase-only blazed gratings to beam steer the sources. Experimental results generated by a mechanically beam-steered array are presented. C1 USA, HARRY DIAMOND LABS, SCLHD ST OP, ADELPHI, MD 20783 USA. RP RAJ, K (reprint author), GEORGE MASON UNIV, DEPT ELECT & COMP ENGN, FAIRFAX, VA 22030 USA. NR 6 TC 11 Z9 11 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUN 10 PY 1993 VL 32 IS 17 BP 3108 EP 3112 PG 5 WC Optics SC Optics GA LE984 UT WOS:A1993LE98400012 PM 20829921 ER PT J AU STEPHENS, PJ JALKANEN, KJ DEVLIN, FJ CHABALOWSKI, CF AF STEPHENS, PJ JALKANEN, KJ DEVLIN, FJ CHABALOWSKI, CF TI ABINITIO CALCULATION OF VIBRATIONAL CIRCULAR-DICHROISM SPECTRA USING ACCURATE POST-SELF-CONSISTENT-FIELD FORCE-FIELDS - TRANS-2,3-DIDEUTERIOOXIRANE SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Letter ID DIPOLE TRANSITION MOMENTS; ATOMIC AXIAL TENSORS; ROTATIONAL STRENGTHS; PROPYLENE-OXIDE; ETHYLENE-OXIDE; GAUGE DEPENDENCE; FREQUENCIES; MOLECULES; POLAR AB The ab initio calculation of harmonic force fields using post-self-consistent-field (post-SCF) methods has recently increased greatly in efficiency. As a result, accurate post-SCF harmonic force fields are now achievable for experimentally accessible chiral molecules. This in turn permits for the first time comparison to experiment of ab initio predictions of vibrational circular dichroism (VCD) spectra based on accurate harmonic force fields. This advance is exploited here in the calculation of the VCD spectrum of trans-2,3-dideuteriooxirane using a large basis set MP2 force field. Excellent accord with recent experimental work is achieved. With the exception of C-H and C-D stretching modes, residual differences between predicted and experimental VCD intensities can be attributed to the incomplete inclusion of correlation in the calculation of atomic axial tensors. C1 UNIV ILLINOIS,NATL CTR SUPERCOMP APPLICAT,URBANA,IL 61801. USA,RES LAB,AMSRL,WT,PC,ABERDEEN PROVING GROUND,MD 21005. RP STEPHENS, PJ (reprint author), UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089, USA. RI Jalkanen, Karl/A-2456-2008 NR 43 TC 27 Z9 27 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD JUN 10 PY 1993 VL 97 IS 23 BP 6107 EP 6110 DI 10.1021/j100125a003 PG 4 WC Chemistry, Physical SC Chemistry GA LG415 UT WOS:A1993LG41500003 ER PT J AU ROY, MJ DAMATO, JJ BURKE, DS AF ROY, MJ DAMATO, JJ BURKE, DS TI ABSENCE OF TRUE SEROREVERSION OF HIV-1 ANTIBODY IN SEROREACTIVE INDIVIDUALS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID HUMAN IMMUNODEFICIENCY VIRUS; HOMOSEXUAL MEN; INFECTION; COHORT AB Objectives.-First, to determine whether there is evidence for loss of human immunodeficiency virus type 1 (HIV-1) antibody in seroreactive individuals. Second, if true seroreversion occurs, to determine its incidence relative to errors in the testing process. Design.- A retrospective cohort study reviewing the results of 5 446 161 HIV-1 antibody tests performed on 2 580 974 individuals (the US Army HIV Data System) from 1985 through 1992. For all patients with one or more seroreactive sample followed by one or more nonreactive sample, we examined available records and retested the samples. Participants.-Serum samples had been obtained from active-duty and retired military personnel, their dependents, and applicants to the military. Results.-Of 4911 individuals reported to be seroreactive for HIV-1 by two independent samples, only six were potential seroreverters. Review of the six cases revealed that five actually were HIV-seroreactive patients who had samples from nonreactive individuals mistakenly attributed to them, while the sixth had a testing error proven by retesting the discrepant specimen. Errors in the testing process were identified (n=23) or suspected (n=3) in another 26 individuals who had not had independent confirmation of reactivity by a second sample. The cumulative error rate was 12.4 per 1 million patients tested. An additional group of 31 uninfected infants appeared to serorevert due to loss of antibody acquired from their HIV-1-infected mothers. Conclusions.-Review of this database demonstrates no evidence for true seroreversion of HIV-1 antibody status. We conclude that if seroreversion occurs at all, it is exceedingly rare. In fact, most (if not all) cases of apparent seroreversion represent errors of attribution or testing. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307. RP ROY, MJ (reprint author), WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307, USA. OI /0000-0002-5704-8094 NR 10 TC 30 Z9 30 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUN 9 PY 1993 VL 269 IS 22 BP 2876 EP 2879 DI 10.1001/jama.269.22.2876 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA LE936 UT WOS:A1993LE93600024 PM 8497091 ER PT J AU SHEN, H WRABACK, M PAMULAPATI, J DUTTA, M NEWMAN, PG BALLATO, A LU, Y AF SHEN, H WRABACK, M PAMULAPATI, J DUTTA, M NEWMAN, PG BALLATO, A LU, Y TI NORMAL INCIDENCE HIGH-CONTRAST MULTIPLE-QUANTUM-WELL LIGHT-MODULATOR BASED ON POLARIZATION ROTATION SO APPLIED PHYSICS LETTERS LA English DT Article ID OPTICAL-PROPERTIES; UNIAXIAL-STRESS; RATIO-GREATER-THAN-100-1; LASER AB A novel optically addressed normal incidence multiple quantum well light modulator based on polarization rotation has been demonstrated for the first time. This modulator employs the anisotropic excitonic absorption created by a thermally induced in-plane uniaxial strain in a multiple quantum well structure to achieve rotations as large as +/- 25-degrees. An exceedingly high contrast ratio of 330:1 has been measured in this device. C1 RUTGERS UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. RP SHEN, H (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,AMSRL EP EF,FT MONMOUTH,NJ 07703, USA. NR 17 TC 28 Z9 28 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 7 PY 1993 VL 62 IS 23 BP 2908 EP 2910 DI 10.1063/1.109193 PG 3 WC Physics, Applied SC Physics GA LE985 UT WOS:A1993LE98500004 ER PT J AU PEROVICH, DK COTA, GF MAYKUT, GA GRENFELL, TC AF PEROVICH, DK COTA, GF MAYKUT, GA GRENFELL, TC TI BIOOPTICAL OBSERVATIONS OF 1ST-YEAR ARCTIC SEA-ICE SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID ALGAE; RESOLUTE AB The interrelationships among snow cover, ice structure, optical properties, and biological activity are of critical importance in understanding the response and behavior of sea ice systems. Of particular concern in this regard are the optical properties of the algae and the effect of snow thickness on biomass accumulation. In this paper we present the first direct in situ measurements of biomass specific diffuse attenuation spectra for arctic ice algae. The data show in situ attenuation values that are about 3 times larger than those obtained from corresponding in vivo absorption measurements, apparently reflecting differences in the geometrical distribution of the algae or the influence of skeletal ice and dissolved organic material. Observations also confirm that maximal algal accumulation occurs when there is a thin layer of snow covering the ice. A new technique to separate the effects of snow and algae in observed transmission spectra is presented. The ratio of transmittance between 600 nm and 450 nm is a sensitive indicator of biomass, while the 700 nm to 600 nm ratio is strongly affected by snow depth. C1 UNIV WASHINGTON,DEPT ATMOSPHER SCI,SEATTLE,WA 98195. UNIV TENNESSEE,GRAD PROGRAM ECOL,KNOXVILLE,TN 37996. RP PEROVICH, DK (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 16 TC 33 Z9 34 U1 1 U2 12 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD JUN 7 PY 1993 VL 20 IS 11 BP 1059 EP 1062 DI 10.1029/93GL01316 PG 4 WC Geosciences, Multidisciplinary SC Geology GA LJ516 UT WOS:A1993LJ51600015 ER PT J AU AGARWAL, SK SPIVEY, JJ TEVAULT, DE AF AGARWAL, SK SPIVEY, JJ TEVAULT, DE TI EFFECT OF WATER-VAPOR IN THE CATALYTIC DESTRUCTION OF CYANOGEN CHLORIDE SO JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS LA English DT Article ID PT/AL2O3 CATALYST; OXIDATION AB The effect of water vapour on the catalytic destruction of cyanogen chloride (CNCl) over a commercial Pt/alpha-alumina catalyst is to increase the overall conversion of CNCl, apparently by hydrolysis, providing a reaction path parallel to oxidation; the presence of water vapour also lowers the apparent activation energy for CNCl destruction, and the selectivity for CO formation is negligible in the presence of water vapour. C1 USA,CRDEC,SMCCRRSCA,ABERDEEN PROVING GROUND,MD 21010. RP AGARWAL, SK (reprint author), RES TRIANGLE INST,CTR PROC RES,POB 12194,RES TRIANGLE PK,NC 27709, USA. NR 12 TC 4 Z9 4 U1 1 U2 1 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK MILTON ROAD, CAMBRIDGE, CAMBS, ENGLAND CB4 4WF SN 0022-4936 J9 J CHEM SOC CHEM COMM JI J. Chem. Soc.-Chem. Commun. PD JUN 7 PY 1993 IS 11 BP 911 EP 912 DI 10.1039/c39930000911 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA LG166 UT WOS:A1993LG16600013 ER PT J AU BUNTE, SW CHABALOWSKI, CF WITTIG, C BEAUDET, RA AF BUNTE, SW CHABALOWSKI, CF WITTIG, C BEAUDET, RA TI ABINITIO STUDY OF THE WEAKLY BONDED CO-CL2 COMPLEX SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID GAUSSIAN BASIS FUNCTIONS; ATOMIC BASIS SETS; FIRST-ROW ATOMS; MOLECULAR CALCULATIONS; CONTRACTION; ENERGIES AB Ab initio structure and vibrational frequency calculations have been performed on the weakly bonded CO-Cl2 complex at the SCF and MP2 levels of approximation. Minima were found for the two linear structures, specifically CO-Cl2 and OC-Cl2, with the latter being slightly more stable than the former. In addition, minima were found for two nonlinear structures, one T-shaped and the other essentially parallel. In the T-shaped structure, the oxygen is very weakly bonded to the chlorines (C2v symmetry). The parallel isomer is slightly lower in energy than the T-shaped structure; however, both of the nonlinear isomers are less stable then either of the linear isomers. The calculated properties of the OC-Cl2 isomer are in excellent agreement with experimental results reported earlier, lending further support to the conclusion that the structure of the experimentally observed isomer is OC-Cl2 rather than CO-Cl2. C1 USA,RES LAB,AMSRL WT PC,ABERDEEN PROVING GROUND,MD 21005. RP BUNTE, SW (reprint author), UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089, USA. NR 13 TC 12 Z9 12 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD JUN 3 PY 1993 VL 97 IS 22 BP 5864 EP 5867 DI 10.1021/j100124a014 PG 4 WC Chemistry, Physical SC Chemistry GA LE951 UT WOS:A1993LE95100014 ER PT J AU LOUWAGIE, J MCCUTCHAN, FE PEETERS, M BRENNAN, TP SANDERSBUELL, E EDDY, GA VANDERGROEN, G FRANSEN, K GERSHYDAMET, GM DELEYS, R BURKE, DS AF LOUWAGIE, J MCCUTCHAN, FE PEETERS, M BRENNAN, TP SANDERSBUELL, E EDDY, GA VANDERGROEN, G FRANSEN, K GERSHYDAMET, GM DELEYS, R BURKE, DS TI PHYLOGENETIC ANALYSIS OF GAG GENES FROM 70 INTERNATIONAL HIV-1 ISOLATES PROVIDES EVIDENCE FOR MULTIPLE GENOTYPES SO AIDS LA English DT Article DE HIV-1; GENOTYPE; PHYLOGENETIC ANALYSIS; GAG; GENETIC VARIATION; INTERNATIONAL ID IMMUNODEFICIENCY-VIRUS TYPE-1; BLOOD MONONUCLEAR-CELLS; REVERSE-TRANSCRIPTASE; DIVERSITY; SEQUENCE; ENV AB Objective: To determine the extent of genetic variation among internationally collected HIV-1 isolates, to analyse phylogenetic relationships and the geographic distribution of different variants. Design: Phylogenetic comparison of 70 HIV-1 isolates collected in 15 countries on four continents. Methods: To sequence the complete gag genome of HIV-1 isolates, build multiple sequence alignments and construct phylogenetic trees using distance matrix methods and maximum parsimony algorithms. Results: Phylogenetic tree analysis identified seven distinct genotypes. The seven genotypes were evident by both distance matrix methods and maximum parsimony analysis, and were strongly supported by bootstrap resampling of the data. The intra-genotypic gag distances averaged 7%, whereas the inter-genotypic distances averaged 14%. The geographic distribution of variants was complex. Some genotypes have apparently migrated to several continents and many areas harbor a mixture of genotypes. Related variants may cluster in certain areas, particularly isolates from a single city collected over a short time. Conclusions: The genetic variation among HIV-1 isolates is more extensive than previously appreciated. At least seven distinct HIV-1 genotypes can be identified. Diversification, migration and establishment of local, temporal 'blooms' of particular variants may all occur concomitantly. C1 PRINCE LEOPOLD INST TROP MED,ANTWERP,BELGIUM. INST PASTEUR COTE IVOIRE,ABIDJAN,COTE IVOIRE. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP LOUWAGIE, J (reprint author), HENRY M JACKSON FDN,RES LAB,1500 E GUDE DR,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 29 TC 340 Z9 342 U1 1 U2 7 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0269-9370 J9 AIDS JI Aids PD JUN PY 1993 VL 7 IS 6 BP 769 EP 780 DI 10.1097/00002030-199306000-00003 PG 12 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA LJ624 UT WOS:A1993LJ62400003 PM 8363755 ER PT J AU KIRBY, WC LAIRD, JR LOVETT, EJ FARRELL, PE AF KIRBY, WC LAIRD, JR LOVETT, EJ FARRELL, PE TI FIXED-WIRE BALLOON DILATION OF CRITICAL PULMONARY STENOSIS SO AMERICAN HEART JOURNAL LA English DT Note ID VALVE STENOSIS; VALVULOPLASTY C1 NATL NAVAL MED CTR, BETHESDA, MD 20814 USA. RP KIRBY, WC (reprint author), WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD JUN PY 1993 VL 125 IS 6 BP 1766 EP 1767 DI 10.1016/0002-8703(93)90770-A PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA LE344 UT WOS:A1993LE34400032 PM 8498322 ER PT J AU BLANK, S AF BLANK, S TI SURVIVAL AND CONSOLIDATION - THE FOREIGN-POLICY OF SOVIET RUSSIA, 1918-1921 - DEBO,RK SO AMERICAN HISTORICAL REVIEW LA English DT Book Review RP BLANK, S (reprint author), USA,WAR COLL,CARLISLE,PA, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU AMER HISTORICAL REVIEW PI WASHINGTON PA 400 A ST SE, WASHINGTON, DC 20003 SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD JUN PY 1993 VL 98 IS 3 BP 915 EP 916 DI 10.2307/2167665 PG 2 WC History SC History GA LH603 UT WOS:A1993LH60300122 ER PT J AU LEANACOX, J LEVIN, S SURANA, R WULFSBERG, E KEENE, CL RAFFEL, LJ SULLIVAN, B SCHWARTZ, S AF LEANACOX, J LEVIN, S SURANA, R WULFSBERG, E KEENE, CL RAFFEL, LJ SULLIVAN, B SCHWARTZ, S TI CHARACTERIZATION OF DENOVO DUPLICATIONS IN 8 PATIENTS BY USING FLUORESCENCE INSITU HYBRIDIZATION WITH CHROMOSOME-SPECIFIC DNA LIBRARIES SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Article ID SUPPRESSION HYBRIDIZATION; MARKER CHROMOSOMES; REARRANGEMENTS; ABERRATIONS; ORIGIN AB Fluorescence in situ hybridization (FISH) with chromosome-specific DNA libraries was performed on samples from eight patients with de novo chromosomal duplications. In five cases, the clinical phenotype and/or cytogenetic evaluations suggested a likely origin of the duplicated material. In the remaining three cases, careful examination of the GTG-banding pattern indicated multiple possible origins; hybridization with more than one chromosome-specific library was performed on two of these cases. In all cases, FISH conclusively identified the chromosomal origin of the duplicated material. In addition, the hybridization pattern was useful in quantitatively delineating the duplication in two cases. C1 UNIV MARYLAND,SCH MED,DEPT OBSTET & GYNECOL,DIV HUMAN GENET,BALTIMORE,MD 21201. UNIV MARYLAND,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. COMMUNITY HOSP,CARILION CTR WOMEN & CHILDREN,ROANOKE VALLEY,VA. NR 21 TC 28 Z9 28 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD JUN PY 1993 VL 52 IS 6 BP 1067 EP 1073 PG 7 WC Genetics & Heredity SC Genetics & Heredity GA LG133 UT WOS:A1993LG13300007 PM 8503441 ER PT J AU BURKE, AP BENSON, W RIBAS, JL ANDERSON, D CHU, WS SMIALEK, J VIRMANI, R AF BURKE, AP BENSON, W RIBAS, JL ANDERSON, D CHU, WS SMIALEK, J VIRMANI, R TI POSTMORTEM LOCALIZATION OF HIV-1 RNA BY INSITU HYBRIDIZATION IN LYMPHOID-TISSUES OF INTRAVENOUS DRUG-ADDICTS WHO DIED UNEXPECTEDLY SO AMERICAN JOURNAL OF PATHOLOGY LA English DT Article ID INFECTED INDIVIDUALS; PERIPHERAL-BLOOD; EXPRESSION; NODES; LYMPHADENOPATHY; IMMUNOHISTOLOGY AB The histopathological alterations in lymphoid tissues and the presence of human immunodeficiency virus (HIV-1) RNA were studied in 25 consecutive autopsies of seropositive, apparently asymptomatic, intravenous drug overdose victims without palpable lymphadenopathy. The majority of lymphoid tissues in a given person showed either a combination of follicular hyperplasia and fragmentation or a combination of involution and depletion. Individuals with involuted and depleted lymphoid tissues were significantly older than those individuals with hyperplasia and fragmentation of follicles. Lymph nodes from individuals with hyperplasia with or without fragmentation were slightly but significantly larger than control nodes from seronegative persons. In tissues from infected cases, HIV-1 RNA was demonstrated by in situ hybridization in 49% of follicular centers showing hyperplasia, 62% of hyperplastic fragmented follicles, and 66% of involuted follicles in a distribution of follicular dendritic cells. No signal was detected in tissues demonstrating follicular depletion or nodes from seronegative persons. Scattered inter- and intrafollicular lymphoid cells with positive signal were present only in nodal tissues with follicular hyperplasia without involution. Tonsils, inguinal, axillary, mediastinal, supraclavicular, mesenteric nodes, and spleen were positive for HIV-1 RNA in 78%, 76%, 67%, 65%, 58% 50%, and 28% of cases, respectively, and the prevalence of positivity reflected the presence of follicles. We conclude that the clinically asymptomatic period of HIV-1 infection is characterized by pathological stages in lymphoid tissues that have distinct histological alterations and distribution of viral RNA. C1 HENRY M JACKSON FDN,ROCKVILLE,MD. ARMED FORCES INST PATHOL,DEPT HEMATOL PATHOL,WASHINGTON,DC 20306. UNIV MARYLAND,DEPT PATHOL,DIV FORENS PATHOL,BALTIMORE,MD 21201. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP BURKE, AP (reprint author), ARMED FORCES INST PATHOL,DEPT CARDIOVASC PATHOL,WASHINGTON,DC 20306, USA. NR 12 TC 30 Z9 30 U1 0 U2 0 PU AMER SOC INVESTIGATIVE PATHOLOGY, INC PI BALTIMORE PA 428 EAST PRESTON ST, BALTIMORE, MD 21202-3993 SN 0002-9440 J9 AM J PATHOL JI Am. J. Pathol. PD JUN PY 1993 VL 142 IS 6 BP 1701 EP 1713 PG 13 WC Pathology SC Pathology GA LF978 UT WOS:A1993LF97800005 PM 8506942 ER PT J AU SEELEY, FB ALEXANDER, JE CONNATSER, RW CONWAY, JS DOWLING, JP AF SEELEY, FB ALEXANDER, JE CONNATSER, RW CONWAY, JS DOWLING, JP TI DIPOLE RADIATORS IN A CAVITY - A RADIO-FREQUENCY ANALOG FOR THE MODIFICATION OF ATOMIC SPONTANEOUS EMISSION RATES BETWEEN MIRRORS SO AMERICAN JOURNAL OF PHYSICS LA English DT Article ID INHIBITED SPONTANEOUS EMISSION; FIELD AB The results of a simple experiment that studies the dipole radiation rate of a radio frequency antenna inside a parallel mirror cavity are presented. Data on the emission rate of the dipole as a function of both mirror spacing and the dipole location between mirrors is taken, and agrees well with a theoretical prediction that holds in both the classical macroscopic and quantum electrodynamical microscopic domains: In particular, theoretically predicted emission suppression and enhancements are observed. This project is then of pedagogical interest in that it is a simple mockup of several famous cavity QED experiments that investigate the change of atomic spontaneous emission rates in such resonators. C1 USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAP SCI DIRECTORATE,AMSMI RD WS ST,REDSTONE ARSENAL,AL 35898. RP SEELEY, FB (reprint author), UNIV ALABAMA,DEPT PHYS,HUNTSVILLE,AL 35899, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 18 TC 11 Z9 11 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0002-9505 J9 AM J PHYS JI Am. J. Phys. PD JUN PY 1993 VL 61 IS 6 BP 545 EP 550 DI 10.1119/1.17206 PG 6 WC Education, Scientific Disciplines; Physics, Multidisciplinary SC Education & Educational Research; Physics GA LE573 UT WOS:A1993LE57300006 ER PT J AU KIANG, JG MCCLAIN, DE AF KIANG, JG MCCLAIN, DE TI EFFECT OF HEAT-SHOCK, [CA-2+]I, AND CAMP ON INOSITOL TRISPHOSPHATE IN HUMAN EPIDERMOID A-431 CELLS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE INOSITOL PHOSPHATE; EPITHELIA ID C-DEPENDENT PROCESSES; POLYMORPHONUCLEAR NEUTROPHILS; SIGNAL TRANSDUCTION; INTRACELLULAR PH; GROWTH-FACTOR; A431 CELLS; CALCIUM; INHIBITION; PHOSPHATIDYLINOSITOL; METABOLISM AB The basal levels of inositol monophosphate, inositol bisphosphate, and inositol trisphosphate (InsP3) in A-431 cells incubated in Na+-Hanks' solution were, respectively, 1.23 +/- 0.18, 0.17 +/- 0.03, and 0.69 +/- 0.07% of the total radioactivity in the cell. When cells were heated, InsP3 increased in a temperature-dependent manner related to the duration of heating. The active form of InsP3, inositol 1,4,5-trisphosphate, increased 237 +/- 17% after heating (45-degrees-C, 20 min) then returned to baseline within 15 min after the return to 37-degrees-C. The heat-induced increase in InsP3 was not observed in the absence of extracellular Ca2+ or with amiloride treatment. Treatment with the nonhydrolyzable GTP analogue 5'-guanylylimidodiphosphate stimulated that component of the InsP3 increase due to G proteins. U-73122, an inhibitor of phospholipase C-mediated processes, blocked the increase in InsP3 resulting from heat exposure. Both pertussis toxin (30 ng/ml, 24 h), an inhibitor of G inhibitory protein, and cholera toxin (1 mug/ml, 1 h), a stimulator of G stimulatory protein, increased InsP3 in unheated cells, and heating failed to induce a further increase, suggesting that heat activates G proteins. Likewise, 8-bromoadenosine 3',5'-cyclic monophosphate (8-BrcAMP), 3-isobutyl-1-methylxanthine, Ro 20-1724, or forskolin increased InsP3 in unheated cells, and heat did not cause an additional increase. The InsP3 increase induced by 8-BrcAMP was inhibited by removal of extracellular Ca2+ or treatment with verapamil, suggesting that an influx of extracellular Ca2+ stimulates InsP3 production. These data are the first to suggest that the heat-induced increase in InsP3 results from both an increase in intracellular Ca2+ concentration and activation of G proteins, while the adenosine 3',5'-cyclic monophosphate-induced increase is due to a rise in intracellular Ca2+ alone. This increase in InsP3 is not related to heat-induced intracellular acidification. C1 ARMED FORCES RADIOBIOL RES INST,DEPT RADIAT BIOCHEM,BETHESDA,MD 20889. RP KIANG, JG (reprint author), WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307, USA. NR 35 TC 26 Z9 26 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD JUN PY 1993 VL 264 IS 6 BP C1561 EP C1569 PN 1 PG 9 WC Physiology SC Physiology GA LL132 UT WOS:A1993LL13200024 ER PT J AU CAROME, MA STRIKER, LJ PETEN, EP MOORE, J YANG, CW STETLERSTEVENSON, WG STRIKER, GE AF CAROME, MA STRIKER, LJ PETEN, EP MOORE, J YANG, CW STETLERSTEVENSON, WG STRIKER, GE TI HUMAN GLOMERULI EXPRESS TIMP-1 MESSENGER-RNA AND TIMP-2 PROTEIN AND MESSENGER-RNA SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE GLOMERULOSCLEROSIS; EXTRACELLULAR MATRIX; GENE EXPRESSION; METALLOPROTEINASE; INHIBITOR; COMPETITIVE POLYMERASE CHAIN REACTION ID POLYMERASE CHAIN-REACTION; DEGRADING NEUTRAL PROTEINASE; TISSUE INHIBITOR; MESANGIAL CELLS; METALLOPROTEINASES-2; PURIFICATION; INVITRO; QUANTITATION AB Alterations in the balance between synthesis and degradation of extracellular matrix may result in glomerulosclerosis. The interaction between metalloproteinases and their inhibitors presumably modulates the rate of glomerular matrix degradation. We examined the gene expression of tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 in human glomeruli and TIMP-2 protein in tissue sections. Kidney tissue was obtained from adults undergoing nephrectomy for renal tumor (n = 9) or biopsy for nephrosis and renal failure (n = 1). Glomeruli were microdissected and subjected to reverse transcription. TIMP cDNAs were quantitated by competitive polymerase chain reaction assays. Five nephrectomy specimens had normal glomeruli and four had diffuse glomerulosclerosis. TIMP-1 and TIMP-2 cDNA levels, detected in glomeruli from all patients, were increased fourfold and threefold, respectively, in patients with glomerulosclerosis. The elevated TIMP cDNA levels could not be attributed to an increased number of glomerular cells. TIMP-2 protein was detected within normal and sclerotic glomeruli. In conclusion, both TIMP genes were expressed in normal glomeruli, and their level of expression was increased in glomerulosclerosis associated with renal carcinoma, suggesting that expression of these inhibitors may correlate with the development of sclerosis. C1 NIDDKD,RENAL CELL BIOL SECT,METAB DIS BRANCH,BLDG 10,RM 3N110,BETHESDA,MD 20892. NCI,PATHOL LAB,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DEPT MED,SERV NEPHROL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RI Stetler-Stevenson, William/H-6956-2012 OI Stetler-Stevenson, William/0000-0002-5500-5808 NR 33 TC 63 Z9 65 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD JUN PY 1993 VL 264 IS 6 BP F923 EP F929 PN 2 PG 7 WC Physiology SC Physiology GA LL133 UT WOS:A1993LL13300093 PM 8322893 ER PT J AU MULLIGAN, ME KRANSDORF, MJ AF MULLIGAN, ME KRANSDORF, MJ TI SEQUESTRA IN PRIMARY LYMPHOMA OF BONE - PREVALENCE AND RADIOLOGIC FEATURES SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article AB OBJECTIVE. Our objective was to determine the prevalence and spectrum of radiologic features of sequestra (detached pieces of bone separated from the involved segment) in cases of primary lymphoma of bone. This is a feature of primary lymphoma of bone that, to our knowledge, has not been reported previously. Recognizing sequestra is important, because a limited differential diagnosis of entities exists when this finding is seen. MATERIALS AND METHODS. We retrospectively reviewed all the clinical and pathologic information and radiologic studies in our archives on 434 cases of skeletal lymphoma. Of these, 246 met our criteria for consideration as cases of primary lymphoma of bone. All cases were pathologically proved. Plain radiographs were available for review in all cases, and CT scans were available in 46. Data on the presence or absence of sequestra, their size and appearance, the bone involved, and the site of involvement were recorded in each case. RESULTS. Sequestra were noted in 28 (11%) of the 246 cases. The size varied from 2 to 45 mm (average, 12 mm), and multiple sequestra were seen in 17 cases. They were seen in the long bones (15 cases), axial skeleton (10 cases), and three other sites (scapula, calcaneus, and third metatarsal). CONCLUSION. Sequestra have been reported in a variety of conditions, including osteomyelitis, eosinophilic granuloma, fibrosarcoma, malignant fibrous histiocytoma, and desmoplastic fibroma. Because sequestra were seen in 11% of the cases of primary lymphoma of bone reviewed in this study, we believe that lymphoma should also be included in the differential diagnosis when a sequestrum is noted on imaging studies. C1 UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. RP MULLIGAN, ME (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,SKELETAL RADIOL SECT,WASHINGTON,DC 20307, USA. NR 10 TC 37 Z9 44 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JUN PY 1993 VL 160 IS 6 BP 1245 EP 1248 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA LW013 UT WOS:A1993LW01300020 PM 8498226 ER PT J AU LANZARO, GC OSTROVSKA, K HERRERO, MV LAWYER, PG WARBURG, A AF LANZARO, GC OSTROVSKA, K HERRERO, MV LAWYER, PG WARBURG, A TI LUTZOMYIA-LONGIPALPIS IS A SPECIES COMPLEX - GENETIC-DIVERGENCE AND INTERSPECIFIC HYBRID STERILITY AMONG 3 POPULATIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SAND FLIES DIPTERA; VISCERAL LEISHMANIASIS; PSYCHODIDAE; DISPERSAL AB The sand fly Lutzomyia longipalpis is the vector of Leishmania donovani chagasi in Latin America. An analysis of genetic variability at 27 enzyme coding loci among three laboratory populations of Lu. longipalpis revealed substantial genetic polymorphism. Levels of genetic distance between all pairwise comparisons of colonies were very high, and consistent with those previously reported among separate species in the genus Lutzomyia. Between 7% and 22% of the loci studied were diagnostic for any two of the colony populations. Experimental hybridization between colonies resulted in the production of sexually sterile male progeny. Our results provide strong evidence that Lu. longipalpis exists in nature as a complex of at least three distinct species. The possible effects of colonization on the genetic makeup of laboratory populations is considered in extending our results to natural populations. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. UNIV NACL,SCH VET MED,TROP DIS RES PROGRAM,HEREDIA,COSTA RICA. RP LANZARO, GC (reprint author), NIAID,MALARIA RES LAB,BLDG 4,BETHESDA,MD 20892, USA. NR 25 TC 120 Z9 122 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1993 VL 48 IS 6 BP 839 EP 847 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LR003 UT WOS:A1993LR00300016 PM 8333579 ER PT J AU ARGYROS, GJ PHILLIPS, YY RAYBURN, DB ROSENTHAL, RR JAEGER, JJ AF ARGYROS, GJ PHILLIPS, YY RAYBURN, DB ROSENTHAL, RR JAEGER, JJ TI WATER-LOSS WITHOUT HEAT-FLUX IN EXERCISE-INDUCED BRONCHOSPASM SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article ID INDUCED ASTHMA; BRONCHOPROVOCATION CHALLENGE; HYPERVENTILATION; TEMPERATURE; STIMULUS; AIR; PATHOGENESIS; HYPOTHESIS; HYPERPNEA; EXCHANGE AB We identified inspired gas conditions that result in no net respiratory heat loss, an isenthalpic condition, but induce a mucosal loss of water. Inspired gas at 37-degrees-C with 47 mm Hg water vapor pressure, 56-degrees-C with 38 mm Hg; and 78-degrees-C with 27 mm Hg has the same heat content as fully saturated air at body temperature. In four normal subjects hyperventilating at a minute ventilation of 30 times their FEV1 for 6 min, expired temperatures at the mouth averaged 39-degrees, 43-degrees, and 43-degrees-C for the three conditions. Retrotracheal esophageal temperatures did not fall in any subject, thereby demonstrating the absence of significant airway cooling. Nine subjects with exercise-induced bronchospasm were tested under the same conditions. Baseline functions showed an FEV1 of 85 +/- 10% of predicted (mean +/- SD), FVC, 98 +/- 13% of predicted, and FEV1/FVC, 79 +/- 4% of predicted. The asthmatic subjects demonstrated postchallenge mean falls in FEV1 of 3.4%, 6.2%, and 10.1% for the three conditions, with bronchospasm increasing as the temperature of the inspired air increased (p = 0.001). The amount of respiratory water lost from the respiratory mucosa significantly correlated with the resultant bronchospastic response as measured by the fall in FEV1 (p = 0.017), but the net respiratory heat lost did not significantly correlate (p = 0.113). This study demonstrates that bronchospasm can be induced without significant respiratory heat loss or airway cooling and suggests that it is proportional to the amount of water lost from mucosal surfaces. C1 USA, MED RES & DEV COMMAND, FT DETRICK, MD USA. WALTER REED ARMY INST RES, DEPT RESP RES, WASHINGTON, DC 20307 USA. UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. JOHNS HOPKINS UNIV, DIV ALLERGY & CLIN IMMUNOL, BALTIMORE, MD 21218 USA. RP ARGYROS, GJ (reprint author), WALTER REED ARMY MED CTR, DEPT MED, PULM & CRIT CARE MED SERV, WARD 77, WASHINGTON, DC 20307 USA. NR 36 TC 34 Z9 34 U1 0 U2 2 PU AMER THORACIC SOC PI NEW YORK PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD JUN PY 1993 VL 147 IS 6 BP 1419 EP 1424 PG 6 WC Respiratory System SC Respiratory System GA LJ667 UT WOS:A1993LJ66700016 PM 8503553 ER PT J AU MONTEMARANO, AD BENSON, PM JAMES, WD CROWE, MA AF MONTEMARANO, AD BENSON, PM JAMES, WD CROWE, MA TI ACUTE PARONYCHIA APPARENTLY CAUSED BY CANDIDA-ALBICANS IN A HEALTHY FEMALE SO ARCHIVES OF DERMATOLOGY LA English DT Letter C1 MARTIN ARMY HOSP,FT BENNING,GA 31905. RP MONTEMARANO, AD (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JUN PY 1993 VL 129 IS 6 BP 786 EP 787 PG 2 WC Dermatology SC Dermatology GA LF983 UT WOS:A1993LF98300020 PM 8507088 ER PT J AU SMITH, WB BAUNCHALK, JM GRABSKI, WJ AF SMITH, WB BAUNCHALK, JM GRABSKI, WJ TI LACK OF EFFICACY OF A BARRIER CREAM IN PREVENTING RHUS DERMATITIS SO ARCHIVES OF DERMATOLOGY LA English DT Letter RP SMITH, WB (reprint author), BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JUN PY 1993 VL 129 IS 6 BP 787 EP 788 PG 2 WC Dermatology SC Dermatology GA LF983 UT WOS:A1993LF98300021 ER PT J AU HEIER, JS ENZENAUER, RW WINTERMEYER, SF DELANEY, M LAPIANA, FP AF HEIER, JS ENZENAUER, RW WINTERMEYER, SF DELANEY, M LAPIANA, FP TI OCULAR INJURIES AND DISEASES AT A COMBAT SUPPORT HOSPITAL IN SUPPORT OF OPERATION-DESERT-SHIELD AND OPERATION-DESERT-STORM SO ARCHIVES OF OPHTHALMOLOGY LA English DT Article AB A retrospective review of all emergency department visits to a combat support hospital (one of four combining to support 150 000 troops) during Operations Desert Shield and Desert Storm was conducted, and all medical records of patients with ocular complaints were analyzed. Ocular injury and/or disease accounted for 14% (108/767) of these visits to the emergency department. Of 108 patients with ocular complaints, corneal foreign bodies (18), ocular burns (14), and traumatic iritis (eight) were the most common injuries treated, while blepharitis and conjunctivitis (16) were the most common diseases. Nineteen (18%) of the 108 patients with ocular complaints were treated during support of the ground war in Iraq (13 were Iraqi prisoners). Ophthalmic injuries accounted for 13% (19/149) of all ground war casualties; however, eight individuals had associated injuries deemed more significant than those of ocular concern. This incidence continues the trend of earlier wars, which has demonstrated a steady increase in ocular injuries. Most US Army troops were issued protective goggles, but only three of 92 American patients wore them at the time of their injury and/or disease. C1 UNIV CALIF SAN FRANCISCO,DIV OCCUPAT & ENVIRONM MED,SAN FRANCISCO,CA 94143. EMERGENCY DEPT,FT DIX,NJ. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP HEIER, JS (reprint author), FITZSIMONS ARMY MED CTR,OPHTHALMOL SERV,AURORA,CO 80045, USA. NR 17 TC 48 Z9 50 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9950 J9 ARCH OPHTHALMOL-CHIC JI Arch. Ophthalmol. PD JUN PY 1993 VL 111 IS 6 BP 795 EP 798 PG 4 WC Ophthalmology SC Ophthalmology GA LF543 UT WOS:A1993LF54300023 PM 8512480 ER PT J AU KRAFT, JF SCHWAB, KA SALAZAR, AM BROWN, HR AF KRAFT, JF SCHWAB, KA SALAZAR, AM BROWN, HR TI OCCUPATIONAL AND EDUCATIONAL ACHIEVEMENTS OF HEAD-INJURED VIETNAM VETERANS AT 15-YEAR FOLLOW-UP SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE EDUCATIONAL ACHIEVEMENT; FOLLOW-UP STUDIES; HEAD INJURY; OCCUPATION; WORK ID NEUROLOGY; LESIONS C1 UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,HEAD INJURY UNIT,BETHESDA,MD 20814. RP KRAFT, JF (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN INVEST,HEAD INJURY UNIT,ATTN HSHL-CI,WASHINGTON,DC 20307, USA. NR 26 TC 18 Z9 18 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD JUN PY 1993 VL 74 IS 6 BP 596 EP 601 DI 10.1016/0003-9993(93)90157-6 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA LG423 UT WOS:A1993LG42300006 PM 8503749 ER PT J AU KIRKLAND, FR BARTONE, PT MARLOWE, DH AF KIRKLAND, FR BARTONE, PT MARLOWE, DH TI COMMANDERS PRIORITIES AND PSYCHOLOGICAL READINESS SO ARMED FORCES & SOCIETY LA English DT Article AB This is a report on a secondary analysis of survey data to assess relationships between commanders' priorities and the psychological readiness of their units. The data were taken from two unrelated surveys-one of U.S. Army company commanders and the other of soldiers in those officers' units. Results indicated that almost all commanders put the highest priority on development of combat skills. Soldiers in units commanded by officers who also accorded high priority to human dimensions were more confident, committed, vertically bonded, psychologically healthy; and the married soldiers were more satisfied with their military and family lives than those in units whose commanders did not put high priority on human dimensions. This study is significant not only for its findings but also because it demonstrates the feasibility of using surveys to provide empirical information about associations between leaders' values and the psychological readiness of their subordinates. C1 USA,MED RES UNIT EUROPE,WASHINGTON,DC 20310. WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307. NR 64 TC 5 Z9 5 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SUM PY 1993 VL 19 IS 4 BP 579 EP 598 DI 10.1177/0095327X9301900406 PG 20 WC Political Science; Sociology SC Government & Law; Sociology GA LW865 UT WOS:A1993LW86500005 ER PT J AU GRUNER, E AF GRUNER, E TI WHAT CODE - OR, NO GREAT ESCAPES - THE CODE OF CONDUCT AND OTHER DREAMS OF RESISTANCE SO ARMED FORCES & SOCIETY LA English DT Article AB The Gulf War POW experience confronts once again with a gap between conduct dictated by the Armed Forces Code of Conduct and actual experience- In the 1990s the differences among the popular lore surrounding POW conduct, expectations written into the Code of Conduct, and POW experiences could not be more pronounced. Many now accept that the Code of Conduct is, at best, ''not enough'' for POWs. The policy on POW conduct in the United States Armed Forces needs a fresh look. The U.S. should bring its POW policies into line with conduct that it condones. Otherwise it is left to American POWs suffering in some distant prison to decide for themselves that the Code of Conduct is irrelevant. RP GRUNER, E (reprint author), US MIL ACAD,DEPT ENGLISH,W POINT,NY 10996, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SUM PY 1993 VL 19 IS 4 BP 599 EP 609 DI 10.1177/0095327X9301900407 PG 11 WC Political Science; Sociology SC Government & Law; Sociology GA LW865 UT WOS:A1993LW86500006 ER PT J AU SHERIDAN, PJ SCHNELL, RC KAHL, JD BOATMAN, JF GARVEY, DM AF SHERIDAN, PJ SCHNELL, RC KAHL, JD BOATMAN, JF GARVEY, DM TI MICROANALYSIS OF THE AEROSOL COLLECTED OVER SOUTH-CENTRAL NEW-MEXICO DURING THE ALIVE FIELD EXPERIMENT, MAY DECEMBER 1989 SO ATMOSPHERIC ENVIRONMENT PART A-GENERAL TOPICS LA English DT Article; Proceedings Paper CT 4TH INTERNATIONAL CONF ON CARBONACEOUS PARTICLES IN THE ATMOSPHERE CY APR 03-05, 1991 CL VIENNA, AUSTRIA SP AUSTRIAN FED MINIST ENVIRONM, AUSTRIAN FED MINIST SCI & TECHNOL, AUSTRIAN SOC ANAL CHEM, TECH UNIV VIENNA, INST ANAL CHEM DE AETHALOMETER; AMMONIUM SULFATE; ANALYTICAL ELECTRON MICROSCOPY; CARBON SOOT; CARBONACEOUS PARTICLES; INDIVIDUAL PARTICLE ANALYSIS; MICROANALYSIS; SULFURIC ACID ID ANALYTICAL ELECTRON-MICROSCOPE; MUNICIPAL INCINERATOR; SPRING 1983; AGASP-II; PARTICLES; STATIONS AB Thirty-eight size-segregated aerosol samples were collected in the lower troposphere over the high desert of south-central New Mexico, using cascade impactors mounted onboard two research aircraft. Four of these samples were collected in early May, sixteen in mid-July, and the remaining ones in December 1989, during three segments of the ALIVE field initiative. Analytical electron microscope analyses of aerosol deposits and individual particles from these samples were performed to physically and chemically characterize the major particulate species present in the aerosol. Air-mass trajectories arriving at the sampling area in the May program were quite different from those calculated for the July period. In general, the May trajectories showed strong westerly winds, while the July winds were weaker and southerly, consistently passing over or very near the border cities of El Paso, Texas, and Ciudad Juarez, Mexico. Aerosol samples collected during the May period were predominantly fine (0.1-0.5 mum dia.), liquid H2SO4 droplets. Samples from the July experiment were comprised mostly of fine, solid (NH4)2SO4 or mostly neutralized sulfate particles. In both sampling periods, numerous other particle classes were observed, including many types with probable terrestrial or anthropogenic sources. The numbers of these particles, however, were small when compared with the sulfates. Composite particle types, including sulfate/crustal and sulfate/carbonaceous, were also found to be present. The major differences in aerosol composition between the May and July samples (i.e. the extensive neutralization of sulfates in the July samples) can be explained by considering the different aerosol transport pathways and the proximity of the July aerosol to the El Paso/Juarez urban plume. Winds during the December experiment were quite variable, and may have contributed to the widely varying aerosol compositions observed in these samples. When the aircraft sampled the El Paso/Juarez urban plume, high concentrations of carbonaceous particles were collected. These C-rich particles were of three distinct types, two of which showed combustion morphologies and the third an irregular morphology. Concurrent aethalometer measurements of aerosol black carbon concentration were well correlated (r = 0.83) with the total carbonaceous particle fraction in the aerosol samples. Carbonaceous particles were not observed in abundance in any of the May or July samples (even when the winds passed over El Paso), and we attribute the high concentrations in December to increased wintertime burning of wood, fossil fuels and other combustibles in the urban area. C1 UNIV WISCONSIN,DEPT GEOSCI,MILWAUKEE,WI 53201. NOAA,ARL,AEROSOL RES STN,BOULDER,CO 80303. USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP SHERIDAN, PJ (reprint author), UNIV COLORADO,NOAA,COOPERAT INST RES ENVIRONM SCI,BOULDER,CO 80309, USA. NR 21 TC 25 Z9 25 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0004-6981 J9 ATMOS ENVIRON A-GEN PD JUN PY 1993 VL 27 IS 8 BP 1169 EP 1183 DI 10.1016/0960-1686(93)90244-S PG 15 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA LJ390 UT WOS:A1993LJ39000002 ER PT J AU GUNTER, RL HANSEN, ADA BOATMAN, JF BODHAINE, BA SCHNELL, RC GARVEY, DM AF GUNTER, RL HANSEN, ADA BOATMAN, JF BODHAINE, BA SCHNELL, RC GARVEY, DM TI AIRBORNE MEASUREMENTS OF AEROSOL OPTICAL-PROPERTIES OVER SOUTH-CENTRAL NEW-MEXICO SO ATMOSPHERIC ENVIRONMENT PART A-GENERAL TOPICS LA English DT Article; Proceedings Paper CT 4TH INTERNATIONAL CONF ON CARBONACEOUS PARTICLES IN THE ATMOSPHERE CY APR 03-05, 1991 CL VIENNA, AUSTRIA SP AUSTRIAN FED MINIST ENVIRONM, AUSTRIAN FED MINIST SCI & TECHNOL, AUSTRIAN SOC ANAL CHEM, TECH UNIV VIENNA, INST ANAL CHEM DE NEPHELOMETER; AETHALOMETER; BLACK CARBON; OPTICAL THICKNESS; ABSORPTION; SCATTERING; EXTINCTION ID CARBON AB We used a three wavelength nephelometer (449, 536 and 690 nm) and an aethalometer on board the NOAA King Air research aircraft to assess the contributions of aerosol optical scattering and absorption to shortwave extinction. The measurements were made over south-central New Mexico in February and July 1989. The winter measurements revealed a shallow, polluted planetary boundary layer with cleaner air above. The summer measurements showed a uniformly mixed planetary boundary layer extending from ground level to the operational ceiling of 4.5 km above ground. In both cases the total optical thickness values for the column were similar (0.03) and the fractional contribution of aerosol absorption to the extinction was between 5 and 10%. These results suggest that the aerosol extinction in summer and winter is similar, even though the planetary boundary layer thickness is quite different during the two seasons. They also demonstrate that a suitably instrumented light aircraft can profile the optical properties of the troposphere with high sensitivity and good spatial resolution. C1 LAWRENCE BERKELEY LAB,BERKELEY,CA 94720. NOAA,ERL,CLIMATE MONITORING & DIAGNOST LAB,BOULDER,CO 80303. UNIV COLORADO,NOAA,COOPERAT INST RES ENVIRONM SCI,BOULDER,CO 80309. ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP GUNTER, RL (reprint author), NOAA,ERL,AIR RESOURCES LAB,AEROSOL RES SECT,325 BROADWAY REARX1,BOULDER,CO 80303, USA. NR 13 TC 7 Z9 7 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0004-6981 J9 ATMOS ENVIRON A-GEN PD JUN PY 1993 VL 27 IS 8 BP 1363 EP 1368 DI 10.1016/0960-1686(93)90262-W PG 6 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA LJ390 UT WOS:A1993LJ39000020 ER PT J AU ECHEVERRIA, P SAVARINO, SJ YAMAMOTO, T AF ECHEVERRIA, P SAVARINO, SJ YAMAMOTO, T TI ESCHERICHIA-COLI DIARRHEA SO BAILLIERES CLINICAL GASTROENTEROLOGY LA English DT Article ID EPEC ADHERENCE-FACTOR; HEAT-STABLE ENTEROTOXIN; PUTATIVE COLONIZATION FACTOR; LINKED IMMUNOSORBENT-ASSAY; POLYMERASE CHAIN-REACTION; HEP-2 CELLS; DNA PROBE; PERSISTENT DIARRHEA; LOCALIZED ADHERENCE; INFANTILE DIARRHEA C1 USN,MED RES INST,ROCKVILLE,MD 20852. JUNTENDO UNIV,SCH MED,DEPT BACTERIOL,BUNKYO KU,TOKYO 113,JAPAN. RP ECHEVERRIA, P (reprint author), USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,RAJVITHI RD,BANGKOK 10400,THAILAND. NR 99 TC 4 Z9 4 U1 0 U2 0 PU BAILLIERE TINDALL PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0950-3528 J9 BAILLIERE CLIN GASTR JI Baillieres Clin. Gastroenterol. PD JUN PY 1993 VL 7 IS 2 BP 243 EP 262 DI 10.1016/0950-3528(93)90042-Q PG 20 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA LT108 UT WOS:A1993LT10800004 PM 8364243 ER PT J AU LUCHINS, AS LUCHINS, EH AF LUCHINS, AS LUCHINS, EH TI GESTALT THEORY, FORMAL MODELS, AND MATHEMATICAL-MODELING SO BEHAVIORAL AND BRAIN SCIENCES LA English DT Article RP LUCHINS, AS (reprint author), US MIL ACAD,DEPT MATH SCI,W POINT,NY 10996, USA. NR 16 TC 1 Z9 1 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0140-525X J9 BEHAV BRAIN SCI JI Behav. Brain Sci. PD JUN PY 1993 VL 16 IS 2 BP 355 EP 356 PG 2 WC Psychology, Biological; Behavioral Sciences; Neurosciences SC Psychology; Behavioral Sciences; Neurosciences & Neurology GA LG847 UT WOS:A1993LG84700079 ER PT J AU SMITH, LA LAFAYE, PJ LAPENOTIERE, HF SPAIN, T DOLLY, JO AF SMITH, LA LAFAYE, PJ LAPENOTIERE, HF SPAIN, T DOLLY, JO TI CLONING AND FUNCTIONAL EXPRESSION OF DENDROTOXIN-K FROM BLACK MAMBA, A K+ CHANNEL BLOCKER SO BIOCHEMISTRY LA English DT Article ID POLYMERASE CHAIN-REACTION; POTASSIUM CHANNELS; MESSENGER-RNA; BINDING-SITES; TRANSMITTER RELEASE; ALPHA-DENDROTOXIN; SNAKE-VENOM; PURIFICATION; ACCEPTORS; PROTEIN AB Mamba dendrotoxins, 7K M(r) polypeptides with three disulfide bonds, selectively inhibit certain fast-activating, voltage-sensitive neuronal K+ channels and have been instrumental in their identification, localization, and purification. However, derivatives with more refined specificity are essential to define the structural and functional properties of the multiple subtypes known to reside in the nervous system. Hence, utilizing a constructed cDNA library from the venom glands of the black mamba (Dendroaspis polylepis), the gene encoding dendrotoxin K was isolated, amplified, and expressed as a maltose-binding fusion protein in the periplasmic space of Escherichia coli. After cleavage of the chaperone from the affinity-purified product, a recombinant protein was isolated and shown to be identical to native dendrotoxin K in its N-terminal sequence, chromatographic behavior, convulsive-inducing activity, and binding to voltage-activated K+ channels in bovine synaptic membranes. This successful expression of refolded active toxin, in adequate yield. makes possible for the first time the preparation of mutants with specificity tailored for each K+ channel subtype, based both on the recently derived three-dimensional structure of alpha-dendrotoxin and the identified binding site on cloned K+ channels. C1 UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT BIOCHEM,LONDON SW7 2AY,ENGLAND. RP SMITH, LA (reprint author), USA,MED RES INST INFECT DIS,DEPT IMMUNOL & MOLEC BIOL,DIV TOXINOL,FREDERICK,MD 21702, USA. RI Dolly, Oliver/G-1532-2012 OI Dolly, Oliver/0000-0002-0861-5320 NR 38 TC 36 Z9 38 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD JUN 1 PY 1993 VL 32 IS 21 BP 5692 EP 5697 DI 10.1021/bi00072a026 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA LF063 UT WOS:A1993LF06300026 PM 8504088 ER PT J AU HWANG, HM HODSON, RE LEWIS, DL SCHOLZE, R AF HWANG, HM HODSON, RE LEWIS, DL SCHOLZE, R TI MICROBIAL DEGRADATIVE ACTIVITY IN GROUND-WATER AT A CHEMICAL WASTE-DISPOSAL SITE SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID TRANSFORMATIONS; POPULATIONS; ADAPTATION; SUBSURFACE; KINETICS; BACTERIA C1 US EPA,ENVIRONM RES LAB,ATHENS,GA 30613. USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61824. UNIV GEORGIA,INST ECOL,DEPT MARINE SCI,ATHENS,GA 30602. UNIV GEORGIA,DEPT MICROBIOL,ATHENS,GA 30602. RP HWANG, HM (reprint author), JACKSON STATE UNIV,DEPT BIOL,JACKSON,MS 39217, USA. NR 13 TC 3 Z9 3 U1 1 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD JUN PY 1993 VL 50 IS 6 BP 856 EP 863 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA KX571 UT WOS:A1993KX57100012 PM 8495063 ER PT J AU LIVINGSTON, RB CROWLEY, JJ THOMPSON, T WILLIAMSON, SK MEYERS, FJ OROURKE, T NEEFE, JR AF LIVINGSTON, RB CROWLEY, JJ THOMPSON, T WILLIAMSON, SK MEYERS, FJ OROURKE, T NEEFE, JR TI PROLONGED, ALTERNATING CHEMOTHERAPY FOR EXTENSIVE SMALL-CELL LUNG-CANCER - A SOUTHWEST-ONCOLOGY-GROUP STUDY SO CANCER LA English DT Article DE LUNG NEOPLASMS; CARCINOMA; SMALL CELL; CLINICAL TRIALS; DRUG THERAPY; COMBINATION; DOSE INTENSITY ID RANDOMIZED TRIAL; ETOPOSIDE; CISPLATIN; CYCLOPHOSPHAMIDE; VP-16 AB Background. Etoposide may be schedule dependent in small cell lung cancer (SCLC), and some data suggest a benefit for increased dose intensity in this disease. This study attempted to optimize dose intensity using an out-patient program that included prolonged, oral etoposide administration. Methods. Cisplatin-etoposide (PE) and cyclophosphamide, doxorubicin, and vincristine (CAV) were alternated at monthly intervals in patients with extensive SCLC. PE was given as cisplatin 50 mg/m2 on days 1 and 8 intravenously (IV) and etoposide 50 mg/m2/day for 14 days by mouth. CAV was administered as cyclophosphamide 60 mg/m2/day for 21 days orally, doxorubicin 20 mg/m2/week for three doses, and vincristine 2 mg IV on day, 1 only. At the end of 4 months, responding patients received an additional course of PE alternating with CAV, and whole-brain irradiation (3000 cGy in 15 fractions) was delivered to clinical complete responders (CR). Results. Among 61 eligible patients, 4 achieved CR, and 11 had a partial remission, by strict Southwest Oncology Group criteria. An additional 20 patients demonstrated greater than 50% tumor shrinkage on one disease assessment but did not have confirming measurements at all sites 4 weeks later. The overall response rate was 57%, including the latter group. The toxicity was primarily hematologic, with three treatment-related deaths from neutropenic infection (5%). Grade 4 neutropenia (< 500/mul) occurred in nine patients (15%) and Grade 4 thrormbocytopenia (< 25,000/mul), in three (5%). Analysis of the delivered dose intensity (in milligrams per square meter per week) as a function of that which was planned revealed a mean of 93% for all courses. Conclusions. Although substitution of prolonged oral etoposide in PE and oral cyclophosphamide in CAV proved to be feasible, these results suggest no advantage over those from other reported series using these alternating regimens in which the agents are pulsed. Experience with alternating PE-CAV for extensive SCLC is reviewed. C1 SW ONCOL GRP STAT CTR,SEATTLE,WA. UNIV KANSAS,MED CTR,KANSAS CITY,KS 66103. UNIV CALIF DAVIS,SACRAMENTO MED CTR,SACRAMENTO,CA 95817. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UNIV KENTUCKY,MED CTR,LEXINGTON,KY 40506. RP LIVINGSTON, RB (reprint author), PUGET SOUND ONCOL CONSORTIUM,SEATTLE,WA, USA. FU NCI NIH HHS [CA-37429, CA-12644, CA-20319] NR 17 TC 3 Z9 3 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD JUN 1 PY 1993 VL 71 IS 11 BP 3509 EP 3513 DI 10.1002/1097-0142(19930601)71:11<3509::AID-CNCR2820711108>3.0.CO;2-# PG 5 WC Oncology SC Oncology GA LE419 UT WOS:A1993LE41900007 PM 8387881 ER PT J AU CARDELLO, AV AF CARDELLO, AV TI SENSORY QUALITY SO CEREAL FOODS WORLD LA English DT Editorial Material RP CARDELLO, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,DIV BEHAV SCI,NATICK,MA 01760, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD JUN PY 1993 VL 38 IS 6 BP 435 EP & PG 0 WC Food Science & Technology SC Food Science & Technology GA LH651 UT WOS:A1993LH65100008 ER PT J AU BRIMFIELD, AA LENZ, DE MAXWELL, DM BROOMFIELD, CA AF BRIMFIELD, AA LENZ, DE MAXWELL, DM BROOMFIELD, CA TI CATALYTIC ANTIBODIES HYDROLYZING ORGANOPHOSPHORUS ESTERS SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 2ND INTERNATIONAL MEETING ON ESTERASES INTERACTING WITH ORGANOPHOSPHORUS COMPOUNDS CY APR 21-24, 1992 CL SALSOMAGGIORE, ITALY DE SOMAN; CATALYTIC ANTIBODY; TRANSITION STATE STABILIZATION; TRIGONAL BIPYRAMID ID SOMAN AB Transition state stabilization is considered one means by which enzymes reduce free energy of activation. The transition state of phosphonic acid anhydrides acted on by OPA hydrolase is postulated to be pentacoordinate, which ordains either a square pyramid or a trigonal bipyramid structure. The advent of catalytic monoclonal antibodies has provided a system in which these assumptions can be tested. By immunizing mice with the protein conjugate of a trigonal bipyramid transition state analog, we have produced hybridomas secreting monoclonal antibodies which hydrolyze phosphonates. To date, activity has been shown toward pinacolyl methylphosphonofluoridic acid (soman). Preliminary results suggest that the antibody is an IgG2a with kappa light chain character. Our results support the trigonal bipyramidal transition state for this group of enzymes. RP BRIMFIELD, AA (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 18 TC 21 Z9 21 U1 0 U2 2 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD JUN PY 1993 VL 87 IS 1-3 BP 95 EP 102 DI 10.1016/0009-2797(93)90029-X PG 8 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA LP303 UT WOS:A1993LP30300013 PM 8344006 ER PT J AU HOSKIN, FCG RAJAN, KS REMY, D WALKER, JE AF HOSKIN, FCG RAJAN, KS REMY, D WALKER, JE TI BIOPOLYMER METAL-CATALYSTS FOR THE HYDROLYSIS OF NERVE GASES SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 2ND INTERNATIONAL MEETING ON ESTERASES INTERACTING WITH ORGANOPHOSPHORUS COMPOUNDS CY APR 21-24, 1992 CL SALSOMAGGIORE, ITALY DE CHELATE; CHITOSAN; CU-2+; DFP; DIMEBU; GLUCOSAMINE; MN-2+; OPA ANHYDRASE; SOMAN; 1,2,2-TRIMETHYLPROPYL METHYL PHOSPHONOFLUORIDATE ID CHITOSAN; CHITIN AB Glucosamine oligomers - monomer through tetramer - form complexes with Cu2+ that catalyse the hydrolysis of the 'nerve gas' 1,2,2-trimethylpropylmethylphosphonofluoridate (soman) by cleaving the P-F bond. A 1/1 glucosamine/Cu2+ ratio whether as glucosamine or glucosamine units, gives the highest hydrolytic rate over the 11.5/1 to 1/1 range. This trend also appears to hold for a glucosamine polymer, chitosan, which, when complexed with Cu2+ also hydrolyzes soman. The relatively low rate of hydrolysis by this polymer-Cu2+ complex, while not yet explainable, is consistent with an extrapolation of the monomer-through-tetramer series. The question may be raised as to whether these biopolymer metal complexes provide any clues to the involvement of Mn2+ in the functioning of one class of P-F cleaving enzymes. C1 IIT,RES INST,CHICAGO,IL 60616. USA,CTR DEV & ENGN,NATICK,MA 01760. RP HOSKIN, FCG (reprint author), IIT,DEPT BIOL,CHICAGO,IL 60616, USA. NR 12 TC 1 Z9 1 U1 1 U2 2 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD JUN PY 1993 VL 87 IS 1-3 BP 109 EP 116 DI 10.1016/0009-2797(93)90031-S PG 8 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA LP303 UT WOS:A1993LP30300015 PM 8343970 ER PT J AU DEFRANK, JJ BEAUDRY, WT CHENG, TC HARVEY, SP STROUP, AN SZAFRANIEC, LL AF DEFRANK, JJ BEAUDRY, WT CHENG, TC HARVEY, SP STROUP, AN SZAFRANIEC, LL TI SCREENING OF HALOPHILIC BACTERIA AND ALTEROMONAS SPECIES FOR ORGANOPHOSPHORUS HYDROLYZING ENZYME-ACTIVITY SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 2ND INTERNATIONAL MEETING ON ESTERASES INTERACTING WITH ORGANOPHOSPHORUS COMPOUNDS CY APR 21-24, 1992 CL SALSOMAGGIORE, ITALY DE OPA ANHYDRASE; ALTEROMONAS; ORGANOPHOSPHORUS; HYDROLYSIS; DFP; SARIN; SOMAN; TABUN AB Previously, a G-type nerve agent degrading enzyme activity was found in a halophilic bacterial isolate designated JD6.5. This organism was tentatively identified as an unknown species of the genus Alteromonas. In order to determine whether this type of enzyme activity was common in other species of Alteromonas, a screening program was initiated. A number of Alteromonas species and five halophilic bacterial isolates were cultured and their crude cell extracts screened for hydrolytic activity against several organophosphorus chemical agents and other related compounds. The samples were also screened for cross-reactivity with a monoclonal antibody raised against the purified enzyme from JD6.5 and for hybridization with a DNA probe based on its N-terminal amino acid sequence A wide spectrum of activities and reactivities were seen, suggesting a significant heterogeneity between the functionally similar enzymes that are present in these bacterial species. Enzymes of the type described here have considerable potential for the decontamination and demilitarization of chemical warfare agents. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ANALYT METHODOL TEAM,ABERDEEN PROVING GROUND,MD 21010. RP DEFRANK, JJ (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,BIOCHEM DECONTAMINAT TEAM,SCBRD RTE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 11 TC 50 Z9 51 U1 3 U2 10 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD JUN PY 1993 VL 87 IS 1-3 BP 141 EP 148 DI 10.1016/0009-2797(93)90035-W PG 8 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA LP303 UT WOS:A1993LP30300019 PM 8393735 ER PT J AU GENTRY, MK SAXENA, A ASHANI, Y DOCTOR, BP AF GENTRY, MK SAXENA, A ASHANI, Y DOCTOR, BP TI IMMUNOCHEMICAL CHARACTERIZATION OF ANTIACETYLCHOLINESTERASE INHIBITORY MONOCLONAL-ANTIBODIES SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 2ND INTERNATIONAL MEETING ON ESTERASES INTERACTING WITH ORGANOPHOSPHORUS COMPOUNDS CY APR 21-24, 1992 CL SALSOMAGGIORE, ITALY DE MONOCLONAL ANTIBODIES; ANTICHOLINESTERASE; INHIBITION; FETAL BOVINE SERUM ACETYLCHOLINESTERASE; TORPEDO-CALIFORNICA ACETYLCHOLINESTERASE AB Monoclonal antibodies (mAbs) were prepared against native or DFP-inhibited Torpedo californica acetylcholinesterase and native or DFP-, MEPQ-, and soman-inhibited fetal bovine serum acetylcholinesterase. The cross reactivity of these antibodies with acetylcholinesterases from various species and their ability to inhibit catalytic activity were determined. Eight antibodies were found to inhibit catalytic activity of either Torpedo or fetal bovine serum enzyme. In all cases the antibodies bound to the native form of the enzymes and in some cases even to the denatured form. None of the antibodies recognized human or horse serum butyrylcholinesterase. Sucrose density gradient centrifugation of enzyme-antibody complexes provided two types of profiles, one with multiple peaks, indicating numerous complexes between tetrameric forms of the enzyme, and the other with single peaks, demonstrating complex formation within the tetrameric form. Different antibodies appeared to interact with slightly different regions, but in all cases the binding encompassed the peripheral anionic site. Decrease in catalytic activity of the enzyme was most likely caused by conformational changes in the enzyme molecule resulting from interaction with these mAbs. C1 ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. RP GENTRY, MK (reprint author), WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307, USA. NR 9 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD JUN PY 1993 VL 87 IS 1-3 BP 227 EP 231 DI 10.1016/0009-2797(93)90046-2 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA LP303 UT WOS:A1993LP30300030 PM 7688272 ER PT J AU BROOMFIELD, CA AF BROOMFIELD, CA TI A PURIFIED RECOMBINANT ORGANOPHOSPHORUS ACID ANHYDRASE PROTECTS MICE AGAINST SOMAN SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 2ND INTERNATIONAL MEETING ON ESTERASES INTERACTING WITH ORGANOPHOSPHORUS COMPOUNDS CY APR 21-24, 1992 CL SALSOMAGGIORE, ITALY DE ORGANOPHOSPHORUS ACID ANHYDRIDE HYDROLASE; MICE; SOMAN; PROTECTION; RECOMBINANT ID PARATHION HYDROLASE GENE; PSEUDOMONAS-DIMINUTA; EXPRESSION; INHIBITION AB Since pharmacologic treatments of organophosphorus anticholinesterases (OPs) are nearing their practical limit other types of treatment are being sought. One approach is the prophylactic administration of scavengers that will detoxify OPs before they reach their critical target site. We have shown that mice which have been treated with a purified organophospborus acid anhydride hydrolase (OPAH) are not measurably affected by doses of soman that are lethal to untreated animals. This result indicates that this approach is worthy of exploration and development for protecting military personnel and agriculture workers against OP intoxication. RP BROOMFIELD, CA (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 12 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD JUN PY 1993 VL 87 IS 1-3 BP 279 EP 284 DI 10.1016/0009-2797(93)90055-4 PG 6 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA LP303 UT WOS:A1993LP30300039 PM 8393744 ER PT J AU DOCTOR, BP BLICK, DW CARANTO, G CASTRO, CA GENTRY, MK LARRISON, R MAXWELL, DM MURPHY, MR SCHUTZ, M WAIBEL, K WOLFE, AD AF DOCTOR, BP BLICK, DW CARANTO, G CASTRO, CA GENTRY, MK LARRISON, R MAXWELL, DM MURPHY, MR SCHUTZ, M WAIBEL, K WOLFE, AD TI CHOLINESTERASES AS SCAVENGERS FOR ORGANOPHOSPHORUS COMPOUNDS - PROTECTION OF PRIMATE PERFORMANCE AGAINST SOMAN TOXICITY SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 2ND INTERNATIONAL MEETING ON ESTERASES INTERACTING WITH ORGANOPHOSPHORUS COMPOUNDS CY APR 21-24, 1992 CL SALSOMAGGIORE, ITALY DE CHOLINESTERASES; PRETREATMENT; TOXICITY; ORGANOPHOSPHATES; SOMAN; SCAVENGERS ID ACETYLCHOLINESTERASE PROPHYLAXIS; BUTYRYLCHOLINESTERASE; MICE AB The present treatment for poisoning by organophosphates consists of multiple drugs such as carbamates, antimuscarinics, and reactivators in pre- and post-exposure modalities. Recently an anticonvulsant, diazapam, has been included as a post-exposure drug to reduce convulsions and increase survival. Most regimens are effective in preventing lethality from organophosphate exposure but do not prevent toxic effects and incapacitation observed in animals and likely to occur in humans. Use of enzymes such as cholinesterases as pretreatment drugs for sequestration of highly toxic organophosphate anticholinesterases and alleviation of side effects and performance decrements was successful in animals, including non-human primates. Pretreatment of rhesus monkeys with fetal bovine serum acetylcholinesterase protected them against lethal effects of soman (up to 5 LD50) and prevented signs of OP toxicity. Monkeys pretreated with fetal bovine serum acetylcholinesterase were devoid of behavioral incapacitation after soman exposure, as measured by serial probe recognition or primate equilibrium platform performance tasks. Use of acetylcholinesterase as a single pretreatment drug provided greater protection against both lethal and behavioral effects of potent organophosphates than current multicomponent drug treatments that prevent neither signs of toxicity nor behavioral deficits. Although use of cholinesterases as single pretreatment drugs provided complete protection, its use for humans may be limited, since large quantities will be required, due to the approximately 1:1 stoichiometry between organophosphate and enzyme. Bisquaternary oximes, particularly HI-6, have been shown to reactivate organophosphate-inhibited acetylcholinesterase at a rapid rate. We explored the possibility that enzyme could be continually reactivated in animals pretreated with fetal bovine serum acetylcholinesterase, followed by an appropriate dose of reactivator, and challenged with repeated doses of sarin. In in vitro experiments, stoichiometry greater than 1:400 for enzyme:sarin was achieved; in vivo stoichiometry in mice was 1:65. Pretreatment of mice with fetal bovine serum acetylcholinesterase and HI-6 amplified the effectiveness of exogenous enzyme as a scavenger for organophosphate. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. ARMSTRONG LAB,SAN ANTONIO,TX 78235. RP DOCTOR, BP (reprint author), WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307, USA. NR 14 TC 30 Z9 30 U1 0 U2 5 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD JUN PY 1993 VL 87 IS 1-3 BP 285 EP 293 DI 10.1016/0009-2797(93)90056-5 PG 9 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA LP303 UT WOS:A1993LP30300040 PM 8343986 ER PT J AU ROACH, JM ELIASSON, AH PHILLIPS, YY AF ROACH, JM ELIASSON, AH PHILLIPS, YY TI THE EFFECT OF PYRIDOSTIGMINE ON BRONCHIAL HYPERREACTIVITY SO CHEST LA English DT Article ID MYASTHENIA-GRAVIS; RESPIRATORY MECHANICS; FLOW LIMITATION; SOMAN; PROTECTION; ATROPINE; THERAPY AB We examined the effect of pyridostigmine (PY) at a dose of 30 mg orally three times a day on nonspecific bronchial hyperreactivity in ten normal nonsmokers (NNS), ten smokers (SM), and ten mild asthmatics (AS). We conducted a double-blind, placebo-controlled, crossover trial, randomly assigning subjects to receive either placebo (PL) or PY before undergoing bronchoprovocation challenge with eucapnic voluntary hyperventilation (EVH) using dry gas. Compliance with PY was confirmed by measuring red blood cell acetylcholinesterase (Achase) levels during both days of testing. While taking PL, the mean (+/- SEM) falls in FVC and FEV, after the bronchoprovocation were as follows: NNS, 1.0 percent (+/- 0.6) FVC and 4.3 percent +/- 1.0) FEV1; SM, 2.4 percent (+/- 1.1) FVC and 2.7 percent +/- 1.3) FEV1; AS, 5.3 percent (+/- 2.3) FVC and 11.5 percent +/- 2.8) FEV1. The mean decreases in FVC and FEV1 while taking PY were as follows: NNS, 1.8 percent (+/- 0.7) FVC and 4.3 percent (+/- 0.8) FEV1; SM, 3.8 percent (+/- 1.4) FVC and 5.2 percent (+/- 1.6) FEV1; AS, 4.4 percent (+/- 1.3) FVC and 11.8 percent (+/- 2.8) FEV1. Within each category, using a paired t test to compare the results on each day of testing, no statistically significant differences were noted. Pyridostigmine at the tested dose has no significant effect on nonspecific bronchial hyperreactivity in normal NNS, SM, or AS. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP ROACH, JM (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 21 TC 7 Z9 7 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD JUN PY 1993 VL 103 IS 6 BP 1755 EP 1758 DI 10.1378/chest.103.6.1755 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA LF719 UT WOS:A1993LF71900024 PM 8404096 ER PT J AU LANCE, EM KIMURA, LH MANIBOG, CN AF LANCE, EM KIMURA, LH MANIBOG, CN TI THE EXPRESSION OF MAJOR HISTOCOMPATIBILITY ANTIGENS ON HUMAN ARTICULAR CHONDROCYTES SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID T-CELL RECEPTOR; MHC CLASS-II; MOLECULAR-BASIS; GENE-PRODUCTS; LYMPHOCYTE-T; IA-ANTIGENS; COMPLEX; ASSOCIATION; RECOGNITION; INTERFERON AB Human articular chondrocytes were analyzed for major histocompatibility (MHC) antigens. The cells were obtained by enzymatic digestion of surgical specimens from patients with osteoarthrosis and rheumatoid arthritis having joint replacement. The analyses of Class I and Class II antigens were performed using microcytotoxicity techniques, as with conventional human leukocyte antigen (HLA) typing, and by immunofluorescence on a flow cytometer with monoclonal antibodies. Eighty-five percent of the chondrocytes had strong representation of Class I molecules, and individual specificities for HLA-A, HLA-B, and HLA-C could be detected. Class II antigens generally were not expressed on chondrocytes from noninflammatory states. In osteoarthrosis, some cells expressed HLA-DP and HLA-DQ, whereas in rheumatoid arthritis, there was an increase in the expression of all Class II antigens. Incubation of chondrocytes with gamma-interferon caused the strong induction of HLA-DR and HLA-DP, whereas HLA-DQ expression was largely unaffected. These results have broad implications for tissue transplantation and autoimmune disease. C1 UNIV HAWAII,JOHN A BURNS SCH MED,DEPT SURG,HONOLULU,HI 96822. TRIPLER ARMY MED CTR,DEPT PATHOL,TRIPLER AMC,HI. RP LANCE, EM (reprint author), SHRINERS HOSP CRIPPLED CHILDREN,IMMUNOL RES LAB,HONOLULU UNIT,1310 PUNAHOU ST,HONOLULU,HI 96826, USA. NR 48 TC 20 Z9 20 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD JUN PY 1993 IS 291 BP 266 EP 282 PG 17 WC Orthopedics; Surgery SC Orthopedics; Surgery GA LF224 UT WOS:A1993LF22400032 PM 7684959 ER PT J AU HONIG, PK WORTHAM, DC ZAMANI, K MULLIN, JC CONNER, DP CANTILENA, LR AF HONIG, PK WORTHAM, DC ZAMANI, K MULLIN, JC CONNER, DP CANTILENA, LR TI THE EFFECT OF FLUCONAZOLE ON THE STEADY-STATE PHARMACOKINETICS AND ELECTROCARDIOGRAPHIC PHARMACODYNAMICS OF TERFENADINE IN HUMANS SO CLINICAL PHARMACOLOGY & THERAPEUTICS LA English DT Article ID CYCLOSPORINE AB Terfenadine is rapidly and nearly completely biotransformed during a first pass to an active acid metabolite. Accumulation of unmetabolized terfenadine has been associated with altered cardiac repolarization. Drug-drug interactions resulting in the accumulation of terfenadine have been reported for ketoconazole and erythromycin. Six subjects were given the recommended dose of terfenadine (60 mg every 12 hours) for 7 days before initiation of oral fluconazole (200 mg once daily). The mean metabolite area under the concentration-time curve increased by 34% and the time to maximum concentration of the metabolite was delayed from 2.3 to 4 hours by concurrent fluconazole. Unmetabolized terfenadine was not present in any subject, and cardiac repolarization was not significantly changed from baseline during any phase of the study. We conclude that a pharmacokinetic interaction between terfenadine and fluconazole exists; however, the absence of accumulation of parent terfenadine in plasma suggests that a clinically significant interaction is unlikely. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL,DIV CLIN PHARMACOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DIV CARDIOL,WASHINGTON,DC 20307. US FDA,ROCKVILLE,MD 20857. RI Zamani, Kaveh/A-9182-2011 FU FDA HHS [FDA 224-88-3006] NR 26 TC 78 Z9 78 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0009-9236 J9 CLIN PHARMACOL THER JI Clin. Pharmacol. Ther. PD JUN PY 1993 VL 53 IS 6 BP 630 EP 636 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA LJ938 UT WOS:A1993LJ93800003 PM 8513654 ER PT J AU BOWERS, W BLAHA, M SANKOVICH, J PATTERSON, D DUBOSE, D AF BOWERS, W BLAHA, M SANKOVICH, J PATTERSON, D DUBOSE, D TI PROSTAGLANDIN-E(2), INTERLEUKIN-1-ALPHA, AND POTASSIUM RELEASE FROM ARTIFICIAL HUMAN SKIN AFTER FREEZE-THAW INJURY SO CRYOBIOLOGY LA English DT Article ID TUMOR NECROSIS FACTOR; VASCULAR ENDOTHELIUM; FROSTBITE INJURIES; CYTOKINES; PHYSIOLOGY; HAND RP BOWERS, W (reprint author), USA,INST ENVIRONM MED,WASHINGTON,DC 20310, USA. NR 15 TC 3 Z9 3 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0011-2240 J9 CRYOBIOLOGY JI Cryobiology PD JUN PY 1993 VL 30 IS 3 BP 272 EP 278 DI 10.1006/cryo.1993.1025 PG 7 WC Biology; Physiology SC Life Sciences & Biomedicine - Other Topics; Physiology GA LE411 UT WOS:A1993LE41100004 PM 8370313 ER PT J AU BURCH, HB WARTOFSKY, L AF BURCH, HB WARTOFSKY, L TI LIFE-THREATENING THYROTOXICOSIS - THYROID STORM SO ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA LA English DT Article ID HYPER-THYROIDISM; GRAVES-DISEASE; HYPERTHYROIDISM; CRISIS; PROPRANOLOL; MANAGEMENT; PATIENT; ESMOLOL; TRIIODOTHYRONINE; HYPOTHYROIDISM C1 WALTER REED ARMY MED CTR,DEPT MED,ENDOCRINE METAB SERV,KYLE METAB UNIT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 88 TC 213 Z9 230 U1 2 U2 14 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8529 J9 ENDOCRIN METAB CLIN JI Endocrinol. Metabol. Clin. North Amer. PD JUN PY 1993 VL 22 IS 2 BP 263 EP 277 PG 15 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA LH883 UT WOS:A1993LH88300006 PM 8325286 ER PT J AU BENSEL, CK AF BENSEL, CK TI THE EFFECTS OF VARIOUS THICKNESSES OF CHEMICAL PROTECTIVE GLOVES ON MANUAL DEXTERITY SO ERGONOMICS LA English DT Article DE CHEMICAL HAZARDS; HANDGEAR; MOTOR SKILLS; PROTECTIVE CLOTHING AB This study was conducted to determine the effects on manual dexterity of the thickness of handcovering. Twelve men were timed as they performed five dexterity tests while barehanded and while wearing each of three thicknesses of chemical protective gloves, 0.18 mm, 0-36 mm, and 0.64 mm. The subjects participated in 14 sessions held on consecutive weekdays. Analysis of the data from six sessions spanning the test period yielded significant main effects (p<0.001) of handwear and of session on all dexterity tests. Mean times were best with bare hands and poorest with the 0-64 mm gloves. Performance with the gloves improved over sessions to the extent that the results with gloves approached or surpassed performance levels achieved with the bare hands during the early sessions. Regression analyses carried out on the data from the last three sessions revealed a linear increase in times to test completion as a function of increases in thickness of the handcovering. The occurrence of damage to the gloves, in the form of punctures and tears, was inversely related to thickness. The findings suggest that selection of the thinnest glove material compatible with protection from the chemical environment and practice working with the handwear will result in relatively efficient manual performance. RP BENSEL, CK (reprint author), USA,CTR RES DEV & ENGN,SOLDIER SCI DIRECTORATE,DIV BEHAV SCI,NATICK,MA 01760, USA. NR 19 TC 39 Z9 39 U1 0 U2 3 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0014-0139 J9 ERGONOMICS JI Ergonomics PD JUN PY 1993 VL 36 IS 6 BP 687 EP 696 DI 10.1080/00140139308967930 PG 10 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA LB736 UT WOS:A1993LB73600009 PM 8513775 ER PT J AU KARLE, JM OLMEDA, R GERENA, L MILHOUS, WK AF KARLE, JM OLMEDA, R GERENA, L MILHOUS, WK TI PLASMODIUM-FALCIPARUM - ROLE OF ABSOLUTE STEREOCHEMISTRY IN THE ANTIMALARIAL ACTIVITY OF SYNTHETIC AMINO ALCOHOL ANTIMALARIAL AGENTS SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE PLASMODIUM-FALCIPARUM; PROTOZOA, PARASITIC; MALARIA; ENANTIOMERS; MEFLOQUINE; HALOFANTRINE; ENPIROLINE ID MOLECULAR-STRUCTURE; INVITRO; MALARIA; QUINIDINE; CRYSTAL C1 WALTER REED ARMY INST RES,DEPT PARASITOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP KARLE, JM (reprint author), WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 17 TC 48 Z9 49 U1 0 U2 5 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD JUN PY 1993 VL 76 IS 4 BP 345 EP 351 DI 10.1006/expr.1993.1042 PG 7 WC Parasitology SC Parasitology GA LJ416 UT WOS:A1993LJ41600002 PM 8513873 ER PT J AU DOWLING, JP AF DOWLING, JP TI SPONTANEOUS EMISSION IN CAVITIES - HOW MUCH MORE CLASSICAL CAN YOU GET SO FOUNDATIONS OF PHYSICS LA English DT Article ID INHIBITED SPONTANEOUS EMISSION; QUANTUM ELECTRODYNAMICS; SELF-ENERGY; LAMB SHIFT; MEDIA; ATOM AB Cavity-induced changes in atomic spontaneous emission rates are often interpreted in terms of quantum electrodynamical zero-point field fluctuations. A completely classical method of computing this effect in terms of the unquantized normal mode structure of the cavity is presented here. Upon applying the result to a classical dipole radiating between parallel mirrors, we obtain the same cavity correction as that for atomic spontaneous emission in such a cavity. The theory is then compared with a recent experiment in the radio-frequency domain. RP DOWLING, JP (reprint author), USA,MISSILE COMMAND,WEAP SCI DIRECTORATE,CTR RES DEV & ENGN,AMSMI-RD-WS-ST,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 17 TC 22 Z9 22 U1 1 U2 8 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0015-9018 J9 FOUND PHYS JI Found. Phys. PD JUN PY 1993 VL 23 IS 6 BP 895 EP 905 DI 10.1007/BF01891512 PG 11 WC Physics, Multidisciplinary SC Physics GA LM319 UT WOS:A1993LM31900004 ER PT J AU BRANDT, HE AF BRANDT, HE TI COMPLEX SPACETIME TANGENT BUNDLE SO FOUNDATIONS OF PHYSICS LETTERS LA English DT Article DE GENERAL RELATIVITY; COMPLEX SPACETIME TANGENT BUNDLE; FINSLER SPACETIME; COMPLEX ANALYTIC MANIFOLDS; KAHLER MANIFOLDS; MAXIMAL PROPER ACCELERATION AB It is demonstrated that the spacetime tangent bundle, in the case of a Finsler spacetime, is complex, provided that the gauge curvature field vanishes. This is accomplished by determining the conditions for the vanishing of the Nijenhuis tensor in the anholonomic frame adapted to the spacetime connection. RP BRANDT, HE (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 0 TC 15 Z9 15 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0894-9875 J9 FOUND PHYS LETT JI Found. Phys. Lett. PD JUN PY 1993 VL 6 IS 3 BP 245 EP 255 DI 10.1007/BF00665729 PG 11 WC Physics, Multidisciplinary SC Physics GA LJ272 UT WOS:A1993LJ27200004 ER PT J AU MIDDLEBROOK, TJ BEHNKEN, SE MITCHELL, WR AF MIDDLEBROOK, TJ BEHNKEN, SE MITCHELL, WR TI STIMULATION OF MICROSOMAL SUPEROXIDE PRODUCTION IN-VITRO BY SELECTED MUNITION COMPOUNDS SO HAZARDOUS WASTE & HAZARDOUS MATERIALS LA English DT Article AB Stimulation of microsomal superoxide production in vitro was measured for various nitroaromatic substrates including methyl viologen, selected key munitions pollutants, and amines that can be formed from the munitions in the environment. Superoxide production mediated by microsomes from hepatic extracts required the addition of a redox active substrate and the cofactor NADPH. In the system, production of superoxide radical was stimulated by four of the five environmental munitions pollutants tested in the order: 1,3,5-trinitrobenzene > 2,4,6-trinitrotoluene > 1,3-dinitrobenzene > 2,4-dinitrotoluene. For all the.parent munition compounds stimulating superoxide production, substitution of analogous amines as substrates resulted in significantly reduced production rates. In general, rates of superoxide production stimulated by the munitions compounds correlated well with their capacity to be reduced biologically. C1 USA,BIOMED RES & DEV LAB,DIV HLTH EFFECTS RES,FT DETRICK,FREDERICK,MD 21702. NR 0 TC 7 Z9 7 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0882-5696 J9 HAZARD WASTE HAZARD JI Hazard. Waste Hazard. Mater. PD SUM PY 1993 VL 10 IS 3 BP 347 EP 355 DI 10.1089/hwm.1993.10.347 PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA MD220 UT WOS:A1993MD22000007 ER PT J AU HALL, DP AF HALL, DP TI ADJUSTMENT DISORDER CRITERIA SO HOSPITAL AND COMMUNITY PSYCHIATRY LA English DT Letter RP HALL, DP (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0022-1597 J9 HOSP COMMUNITY PSYCH PD JUN PY 1993 VL 44 IS 6 BP 592 EP 592 PG 1 WC Public, Environmental & Occupational Health; Psychiatry SC Public, Environmental & Occupational Health; Psychiatry GA LC960 UT WOS:A1993LC96000022 PM 8514314 ER PT J AU HUDAK, RP BROOKE, PP FINSTUEN, K RILEY, P AF HUDAK, RP BROOKE, PP FINSTUEN, K RILEY, P TI HEALTH-CARE ADMINISTRATION IN THE YEAR 2000 - PRACTITIONERS VIEWS OF FUTURE-ISSUES AND JOB REQUIREMENTS SO HOSPITAL & HEALTH SERVICES ADMINISTRATION LA English DT Article AB This research identifies the most important domains in health care administration (HCA) from now to the year 2000 and differentiates job skill, knowledge, and ability requirements necessary for successful management. Fellows of the American College of Healthcare Executives from about half of the United States responded to two iterations of a Delphi mail inquiry. Fellows identified 102 issues that were content-analyzed into nine domains by an HCA expert panel. Domains, in order of ranked importance, were cost/finance, leadership, professional staff interactions, health care delivery concepts, accessibility, ethics, quality/risk management, technology, and marketing. In the second Delphi iteration, Fellows reviewed domain results and rated job requirements on required job importance. Results indicated that while a business orientation is needed for organizational survival, an equal emphasis on person-oriented skills, knowledge, and abilities is required. C1 USA,SCH MED FIELD SERV,FT SAM HOUSTON,TX 78234. USA,BAYLOR UNIV,ACAD HLTH SCI,GRAD PROGRAM HLTH CARE ADM,FT SAM HOUSTON,TX 78234. USA,HLTH SERV COMMAND,FT SAM HOUSTON,TX 78234. RP HUDAK, RP (reprint author), USA,BAYLOR UNIV,GRAD PROGRAM,ACAD HLTH SCI,DIV HLTH CARE ADM,ROOM 1412,FT SAM HOUSTON,TX 78234, USA. NR 38 TC 17 Z9 17 U1 2 U2 2 PU AMER COLL HEALTHCARE EXEC HEALTH ADMINISTRATION PRESS PI CHICAGO PA ONE NORTH FRANKLIN ST SUITE 1700, CHICAGO, IL 60606 SN 8750-3735 J9 HOSP HEALTH SERV ADM JI Hosp. Health Serv. Adm. PD SUM PY 1993 VL 38 IS 2 BP 181 EP 195 PG 15 WC Health Policy & Services SC Health Care Sciences & Services GA LC973 UT WOS:A1993LC97300003 PM 10126189 ER PT J AU VICTOR, KD PASCUAL, V STITZEL, AE TSOKOS, GC CAPRA, JD SPITZER, RE AF VICTOR, KD PASCUAL, V STITZEL, AE TSOKOS, GC CAPRA, JD SPITZER, RE TI NUCLEOTIDE-SEQUENCE OF A HUMAN AUTOANTIBODY TO THE ALTERNATIVE PATHWAY C3/C5 CONVERTASE (C3NEF) SO HYBRIDOMA LA English DT Article ID VARIABLE REGION GENES; C3 NEPHRITIC FACTOR; ANTI-DNA ANTIBODY; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; UNMUTATED COPIES; GERMLINE GENES; RESPONSES; CELLS; IGG AB The production of autoantibodies to the alternative pathway C3/C5 convertase or C3 Nephritic Factor (C3NeF) is one characteristic of membranoproliferative glomerulonephritis. The complete nucleotide sequences of the heavy and light chain variable regions of an IgG C3NeF produced by an EBV transformed B cell line derived from a patient with membranoproliferative glomerulonephritis were determined. The V(H) and V(L) gene segments used by this C3NeF are extensively mutated suggesting that antigenic selection and affinity maturation may occur during the generation of these autoantibodies. C1 UNIV TEXAS,SW MED CTR,DEPT MICROBIOL,5323 HARRY HINES BLVD,DALLAS,TX 75235. SUNY HLTH SCI CTR SYRACUSE,DEPT PEDIAT,SYRACUSE,NY 13210. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. FU NIAID NIH HHS [AI12127] NR 23 TC 4 Z9 4 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0272-457X J9 HYBRIDOMA JI Hybridoma PD JUN PY 1993 VL 12 IS 3 BP 231 EP 237 DI 10.1089/hyb.1993.12.231 PG 7 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Immunology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology GA LH387 UT WOS:A1993LH38700001 PM 8395463 ER PT J AU AGRAWAL, GP BOWDEN, CM AF AGRAWAL, GP BOWDEN, CM TI CONCEPT OF LINEWIDTH ENHANCEMENT FACTOR IN SEMICONDUCTOR-LASERS - ITS USEFULNESS AND LIMITATIONS SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article ID DISTRIBUTED FEEDBACK AB The usefulness and the limitations of the concept of the linewidth enhancement factor a in semiconductor lasers are examined by considering the laser dynamics without the rate-equation approximation. The rate equations with a constant value of alpha can be used for semiconductor lasers operating continuously or modulated directly such that the carrier density does not change significantly during each modulation cycle. A new set of generalized Bloch equations should be used whenever subpicosecond optical pulses are involved. C1 USA,MISSILE COMMAND,WEAPONS SCI DIRECTORATE,AMSMI RD WS-ST,REDSTONE ARSENA,AL 35898. RP AGRAWAL, GP (reprint author), UNIV ROCHESTER,INST OPT,ROCHESTER,NY 14627, USA. RI Agrawal, Govind/D-5380-2013 OI Agrawal, Govind/0000-0003-4486-8533 NR 13 TC 16 Z9 17 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD JUN PY 1993 VL 5 IS 6 BP 640 EP 642 DI 10.1109/68.219695 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA LK182 UT WOS:A1993LK18200019 ER PT J AU STEAD, M SIMONIS, GJ PHAM, J LEAVITT, R TOWNER, F GUPTA, N AF STEAD, M SIMONIS, GJ PHAM, J LEAVITT, R TOWNER, F GUPTA, N TI 50-DB INTEGRATABLE SELF-ALIGNED STARK-LADDER ELECTROABSORPTION WAVE-GUIDE MODULATOR SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article ID LOCALIZATION AB A GaAs/AlGaAs-superlattice rib-waveguide optical modulator is reported which is fabricated with a single mask and a self-aligned electrode. It utilizes Stark-ladder transitions in the 775-810-nm wavelength range, for which the GaAs substrate is opaque. A modulation of 25 dB and modulation slope of 17 dB / V mm was achieved at 777 nm with a - 2 V bias in a 2.2-mm-long waveguide. A 50-dB modulation was achieved near 785 nm for a 6.2-V applied bias. Incorporation of additional passive superlattices into the structure resulted in an unbiased planar-waveguide loss of 1 cm-1 or less for wavelengths longer than 795 nm, making this waveguide structure also suitable for interconnect waveguides and device integration without further material regrowth or diffusion processing. C1 MARTIN MARIETTA CORP LABS,BALTIMORE,MD 21227. RP STEAD, M (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. RI Gupta, Neelam/B-8702-2013 NR 8 TC 3 Z9 3 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD JUN PY 1993 VL 5 IS 6 BP 689 EP 692 DI 10.1109/68.219712 PG 4 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA LK182 UT WOS:A1993LK18200036 ER PT J AU ZU, LQ LU, Y SHEN, H DUTTA, M AF ZU, LQ LU, Y SHEN, H DUTTA, M TI DELAY-TIME IN GAAS HIGH-POWER HIGH-SPEED PHOTOCONDUCTIVE SWITCHING DEVICES SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article AB The delay time between the beginning of optical illumination and the onset of switching in the transient response of semi-insulating GaAs high-power high-speed photoconductive switching devices is investigated in this letter. The field- and laser-energy-dependent optical absorption coefficient is used to explain the experimentally observed open-state-field and laser-energy-dependent delay time. Our calculations agree with the experimental results. C1 GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. USA,ELECTR TECHNOL & DEVICES LAB,SLCET ED,FT MONMOUTH,NJ 07703. RP ZU, LQ (reprint author), RUTGERS UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855, USA. NR 9 TC 4 Z9 6 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD JUN PY 1993 VL 5 IS 6 BP 710 EP 712 DI 10.1109/68.219719 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA LK182 UT WOS:A1993LK18200043 ER PT J AU HUANG, TC SIMONIS, GJ STEAD, M LEAVITT, RP AF HUANG, TC SIMONIS, GJ STEAD, M LEAVITT, RP TI A Y-JUNCTION OPTICAL SWITCH BASED ON FIELD-INDUCED CONTROL OF REFRACTIVE-INDEX SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article AB A new type of Y-junction optical switch structure based on refractive-index-controllable waveguides is investigated. Switching operation is observed when polarity of the reverse bias applied between the two arms of the Y-branch is alternated. A crosstalk of less than - 12 dB is achieved with a transition length of less than 400 mum at a 1.06-mum wavelength. An optical switch is realizable with this structure that has small size, large optical bandwidth, and high speed. RP HUANG, TC (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 8 TC 6 Z9 6 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD JUN PY 1993 VL 5 IS 6 BP 712 EP 715 DI 10.1109/68.219720 PG 4 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA LK182 UT WOS:A1993LK18200044 ER PT J AU STURZEBECHER, DJ ZHOU, XD ZHANG, XS DARYOUSH, AS AF STURZEBECHER, DJ ZHOU, XD ZHANG, XS DARYOUSH, AS TI OPTICALLY CONTROLLED OSCILLATORS FOR MILLIMETER-WAVE PHASED-ARRAY ANTENNAS SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article AB A new approach for the design of optically synchronized millimeter-wave local oscillators based on a subharmonically injection-locked phase-lock-loop technique is introduced. The experimental results support the desired goal of frequency and phase coherency, phase shift control of millimeter-wave oscillators, and self-oscillating mixing to downconvert a millimeter-wave RF signal. Experimental results and theoretical analysis show the advantages of the proposed approach: larger locking range of two subharmonically locked oscillators, lower FM noise degradation, and smaller phase error caused by frequency detuning. C1 DREXEL UNIV,CTR MICROWAVE LIGHTWAVE ENGN,DEPT ECE,PHILADELPHIA,PA 19104. RP STURZEBECHER, DJ (reprint author), USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 11 TC 15 Z9 15 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD JUN-JUL PY 1993 VL 41 IS 6-7 BP 998 EP 1004 DI 10.1109/22.238515 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA MC680 UT WOS:A1993MC68000014 ER PT J AU RAY, P AF RAY, P TI BOTULINUM TOXIN A INHIBITS ACETYLCHOLINE-RELEASE FROM CULTURED NEURONS IN-VITRO SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Article DE PC12 CELLS; NERVE GROWTH FACTOR; BOTULINUM TOXIN-A; ACETYLCHOLINE ID PC12 CELLS; TETANUS TOXIN; NEUROTOXIN-A; LIGHT CHAIN AB Clostridium botulinum type toxin A (BoTx) blocks stimulus-induced acetylcholine (ACh) release from presynaptic nerve terminals at peripheral neuromuscular junctions. However, the detailed mechanism of this effect remains elusive. One obstacle in solving this problem is the lack of a suitable in vitro homogenous cholinergic neuronal model system. We studied the clonal pheochromocytoma PC12 cell line to establish such a model. PC12 cells were differentiated in culture by treatment with 50 ng/ml nerve growth factor (NGF) for 4 days to enhance cellular ACh synthesis and release properties. Stimulation of these cells with high K+ (80 mM) in the perfusion medium markedly increased calcium-dependent [H-3]ACh release compared to undifferentiated cells. Stimulated [H-3]ACh release was totally inhibited by pretreatment of cells with 2 nM BoTx for 2 h. BoTx inhibition of [H-3]ACh release was time- and concentration-dependent. A 50% inhibition was obtained after 2 h incubation with a low (0.02 nM) toxin concentration. The time required for 2 mM BoTx to cause a measurable inhibition (18%) of stimulated [H-3]ACh release was 30 min. Botulinum toxin inhibition of stimulated ACh release was prevented by toxin antiserum and heat treatment, suggesting the specificity of the toxin effect. Our results show that by differentiation with NGF, PC12 cells can be shifted from an insensitive to a sensitive state with respect to BoTx inhibition of stimulated ACh release. This cell line, therefore, may serve as a valuable in vitro cholinergic model system to study the mechanism of action of BoTx. RP RAY, P (reprint author), WALTER REED ARMY INST RES,DEPT BIOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 25 TC 12 Z9 12 U1 0 U2 1 PU SOC IN VITRO BIOLOGY PI UPPER MARLBORO PA 9315 LARGO DR W #255, UPPER MARLBORO, MD 20774-4755 SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD JUN PY 1993 VL 29A IS 6 BP 456 EP 460 PG 5 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA LM383 UT WOS:A1993LM38300007 PM 8331029 ER PT J AU ORR, N ROBIN, G COHEN, D ARNON, R LOWELL, GH AF ORR, N ROBIN, G COHEN, D ARNON, R LOWELL, GH TI IMMUNOGENICITY AND EFFICACY OF ORAL OR INTRANASAL SHIGELLA-FLEXNERI 2A AND SHIGELLA-SONNEI PROTEOSOME-LIPOPOLYSACCHARIDE VACCINES IN ANIMAL-MODELS SO INFECTION AND IMMUNITY LA English DT Article ID IGA; IMMUNITY AB Immunity against shigellosis has been shown to correlate with the presence of antibodies specific for Shigella lipopolysaccharide (LPS). We here propose a new candidate vaccine for shigellosis composed of purified Shigella flexneri 2a or Shigella sonnei LPS hydrophobically complexed with group C type 2b Neisseria meningitidis outer membrane protein proteosomes. Immunization of mice either orally or intranasally with this complex induced specific homologous anti-LPS antibodies in both intestinal and respiratory secretions as well as in sera. Strong anamnestic responses were found after two or three immunizations. LPS alone, alkaline-detoxified LPS, or alkaline-detoxified LPS complexed with proteosomes was not effective. Oral or intranasal immunization of guinea pigs with two or more doses of this proteosome-LPS vaccine elicited homologous protection against Shigella keratoconjunctivitis (Sereny test). These data demonstrate that proteosomes can be used as an effective mucosal vaccine delivery system and that orally or intranasally administered acellular vaccines can protect against Shigella infections. C1 WEIZMANN INST SCI,DEPT CHEM IMMUNOL,IL-76100 REHOVOT,ISRAEL. WALTER REED ARMY MED CTR,DIV PATHOL,WASHINGTON,DC 20307. RP ORR, N (reprint author), ISRAEL DEF FORCES,MED CORPS,MILITARY POST 02149,ISRAEL. NR 31 TC 82 Z9 82 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 1993 VL 61 IS 6 BP 2390 EP 2395 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA LE498 UT WOS:A1993LE49800017 PM 8500877 ER PT J AU AK, M BOWER, JH HOFFMAN, SL SEDEGAH, M LEES, A CARTER, M BEAUDOIN, RL CHAROENVIT, Y AF AK, M BOWER, JH HOFFMAN, SL SEDEGAH, M LEES, A CARTER, M BEAUDOIN, RL CHAROENVIT, Y TI MONOCLONAL-ANTIBODIES OF 3 DIFFERENT IMMUNOGLOBULIN-G ISOTYPES PRODUCED BY IMMUNIZATION WITH A SYNTHETIC PEPTIDE OR NATIVE PROTEIN PROTECT MICE AGAINST CHALLENGE WITH PLASMODIUM-YOELII SPOROZOITES SO INFECTION AND IMMUNITY LA English DT Article ID CIRCUMSPOROZOITE PROTEIN; VACCINES; MALARIA; BERGHEI AB Passive transfer of monoclonal antibodies (MAbs) against malaria circumsporozoite (CS) proteins protects animals against malaria. Active immunization with synthetic or recombinant peptides induces a level of polyclonal antibodies to sporozoites comparable to those found after passive immunization but does not provide comparable protection. In the Plasmodium yoelii system, synthetic or recombinant peptide-induced antibodies have never been shown to protect. The current studies were designed to determine whether immunogen structure (native protein versus synthetic peptide) or immunoglobulin G (IgG) subclass of antibodies was responsible for the absolute differences between protective, passively transferred MAbs and nonprotective, actively induced polyclonal antibodies. In this study we produced two MAbs, QGP-S1 (IgG1) and QGP-S2 (IgG2b), by immunization with a synthetic peptide based on the P. yoelii CS major repeat, (QGPGAP)4, conjugated to keyhole limpet hemocyanin. These MAbs were compared to NYS1 (IgG3), an anti-CS protein MAb previously produced by immunization with irradiated P. yoelii sporozoites, which recognizes (QGP GAP)2. QGP-S1 and QGP-S2 passively transferred protection. However, when compared with NYS1, there was a hierarchy of protection, NYS1 > QGP-S1 > QGP-S2. There was no correlation between antibody level at challenge as determined by immunofluorescent antibody test against sporozoites or enzyme-linked immunosorbent assay against (QGPGAP)2 or apparent antibody avidity for (QGPGAP)2 by sodium thiocyanate elution assay. The data demonstrate that a synthetic peptide can induce protective antibodies and that a specific antibody subclass is not required for protection. Work to determine whether antibody affinity or fine specificity can explain the hierarchy of protection among the MAbs is under way. C1 USN,MED RES INST,MALARIA PROGRAM,BETHESDA,MD 20889. PAN AMER HLTH ORG,WASHINGTON,DC 20037. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. NR 18 TC 21 Z9 21 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 1993 VL 61 IS 6 BP 2493 EP 2497 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA LE498 UT WOS:A1993LE49800031 PM 8500885 ER PT J AU MICHAEL, NL VAHEY, M CHANG, G COOLEY, J EHRENBERG, P RUDERMAN, J BIRX, D REDFIELD, R AF MICHAEL, NL VAHEY, M CHANG, G COOLEY, J EHRENBERG, P RUDERMAN, J BIRX, D REDFIELD, R TI GP160 VACCINE THERAPY IN AN HIV-1-INFECTED PATIENT IS ASSOCIATED WITH A FALL IN VIRAL BURDEN - ANTIGENIC SHIFT, AND VIRAL REGULATORY SEQUENCE MUTATIONS SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. HM JACKSON FDN,ROCKVILLE,MD. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD JUN PY 1993 VL 6 IS 6 BP 678 EP 678 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA LC751 UT WOS:A1993LC75100059 ER PT J AU MCCUTCHAN, F LOUWAGIE, J EDDY, G VANDERGROEN, G PIOT, P MYERS, G BURKE, D AF MCCUTCHAN, F LOUWAGIE, J EDDY, G VANDERGROEN, G PIOT, P MYERS, G BURKE, D TI IDENTIFICATION OF MULTIPLE GENETIC SUBTYPES OF HIV-1 AND EVIDENCE FOR GEOGRAPHIC DISPERSAL SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Meeting Abstract C1 HENRY M JACKSON FDN,ROCKVILLE,MD. PRINCE LEOPOLD INC TROP MED,ANTWERP,BELGIUM. LOS ALAMOS NATL LAB,LOS ALAMOS,NM 87544. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD JUN PY 1993 VL 6 IS 6 BP 685 EP 685 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA LC751 UT WOS:A1993LC75100087 ER PT J AU LOOMIS, LD MANN, F WAHREN, B REDFIELD, RR BIRX, DL AF LOOMIS, LD MANN, F WAHREN, B REDFIELD, RR BIRX, DL TI COMPARING THE HUMORAL RESPONSE IN HIV-1-INFECTED PATIENT VOLUNTEERS POST GP-160 OR GP120 IMMUNIZATION BY PEPSCAN SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Meeting Abstract C1 HENRY M JACKSON FDN,RETROVIRAL RES LAB,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,ROCKVILLE,MD 20850. NATL BACTERIOL LAB,S-10521 STOCKHOLM,SWEDEN. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD JUN PY 1993 VL 6 IS 6 BP 708 EP 708 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA LC751 UT WOS:A1993LC75100182 ER PT J AU POLONIS, VR REDFIELD, RR HOOVENLEWIS, C LIU, YL GARTNER, S REED, W AF POLONIS, VR REDFIELD, RR HOOVENLEWIS, C LIU, YL GARTNER, S REED, W TI BIOSYNTHESIS OF HIV-1 ENVELOPE PROTEINS IN NORMAL AND NEOPLASTIC T-CELLS AND MACROPHAGES SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. HENRY M JACKSON FDN,ROCKVILLE,MD 20850. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD JUN PY 1993 VL 6 IS 6 BP 712 EP 712 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA LC751 UT WOS:A1993LC75100196 ER PT J AU MOSCA, JD GARTNER, S KAUSHAL, S PERERA, P YU, Z RITCHEY, DR DARCY, DR XU, J LIU, Y BURKE, DS AF MOSCA, JD GARTNER, S KAUSHAL, S PERERA, P YU, Z RITCHEY, DR DARCY, DR XU, J LIU, Y BURKE, DS TI HIV-1 INFECTION OF HUMAN STROMAL CELLS REPROGRAMS CYTOKINE PRODUCTION SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Meeting Abstract C1 HENRY M JACKSON FDN RES LABS,ROCKVILLE,MD. WALTER REED ARMY INST RES,ROCKVILLE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD JUN PY 1993 VL 6 IS 6 BP 736 EP 736 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA LC751 UT WOS:A1993LC75100292 ER PT J AU HAUS, JW CHUNGYAU, F BOWDEN, CM AF HAUS, JW CHUNGYAU, F BOWDEN, CM TI NONLINEAR ELECTROMAGNETIC-FIELD RESPONSE OF HIGH T(C) SUPERCONDUCTING MICROPARTICLE COMPOSITES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID INFRARED SPHERE RESONANCE; BA-CU-O; PARTICLES; FILMS AB We consider a dielectric host medium with spherical high T(c) superconducting particles embedded in it. The nonlinear electromagnetic field response of the composite superconductor material is calculated using a time-dependent Landau-Ginzburg model. Specifically, we predict a strong frequency dependence of the nonlinear susceptibility, field intensity dependence of the transition temperature, and third harmonic generation. The mechanism for the nonlinearity is the breaking of quasi-particle bonds by the electromagnetic field. C1 USA,MISSILE COMMAND,AMSMI RD WS ST RES DEV & ENGN CTR,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898. RP HAUS, JW (reprint author), RENSSELAER POLYTECH INST,DEPT PHYS,TROY,NY 12180, USA. NR 20 TC 1 Z9 1 U1 1 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 1 PY 1993 VL 73 IS 11 BP 7556 EP 7562 DI 10.1063/1.354004 PG 7 WC Physics, Applied SC Physics GA LE952 UT WOS:A1993LE95200082 ER PT J AU ARANDA, FJ RAO, DVGLN ROACH, JF TAYEBATI, P AF ARANDA, FJ RAO, DVGLN ROACH, JF TAYEBATI, P TI 3RD-ORDER NONLINEAR-OPTICAL INTERACTIONS OF C-60 AND C-70 SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB We measured the third-order nonlinear optical susceptibility chi(3) for C60 and C70 SolUtions as a function of concentration using degenerate four-wave mixing with picosecond pulses at 532 nm. From the observed minimum we were able to obtain the real and imaginary parts of chi(3). The real part is negative at this wavelength. Values of the real and imaginary components of the molecular hyperpolarizability (gamma) calculated are in the range 10(-31) esu. C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. FOSTER MILLER INC,WALTHAM,MA 02154. RP ARANDA, FJ (reprint author), UNIV MASSACHUSETTS,DEPT PHYS,BOSTON,MA 02125, USA. RI Rao, Devulapalli/L-8863-2015 NR 10 TC 21 Z9 22 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 1 PY 1993 VL 73 IS 11 BP 7949 EP 7951 DI 10.1063/1.353948 PG 3 WC Physics, Applied SC Physics GA LE952 UT WOS:A1993LE95200135 ER PT J AU UYEHARA, CFT PICHOFF, BE SIM, HH UEMURA, HS NAKAMURA, KT AF UYEHARA, CFT PICHOFF, BE SIM, HH UEMURA, HS NAKAMURA, KT TI HYPEROXIC EXPOSURE ENHANCES AIRWAY REACTIVITY OF NEWBORN GUINEA-PIGS SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE AIRWAY SMOOTH MUSCLE; OXYGEN TOXICITY; ISOMETRIC FORCE ID SMOOTH-MUSCLE; BRONCHOPULMONARY DYSPLASIA; INVITRO; OXYGEN; LUNG; RATS; RESPONSIVENESS; RESPONSES; TOXICITY; ONTOGENY AB To determine whether altered airway smooth muscle contractility contributes to airway hyperreactivity resulting from hyperoxic exposure, in vitro contractile responses of airways to two physiological constrictors, acetylcholine (10(-9) to 10(-4) M) and histamine (10(-8) to 10(-4) M), were examined. Extrathoracic trachea, intrathoracic trachea, and bronchus from 1- to 2-day-old (new-born) guinea pigs exposed to 85% oxygen for 84 h were compared with tissues obtained from newborns reared in room air. Responses in the presence and absence of aspirin (ASA; 10(-3) M) were compared. Hyperoxic exposure did not affect the histology of the airway epithelia. Contractile responses to acetylcholine and histamine were similar. Without ASA, maximal tensions generated were higher in both extrathoracic and intrathoracic trachea obtained from hyperoxia-exposed neonates than in trachea from newborns reared in room air. ASA caused maximal tensions of trachea from newborns reared in room air to increase but did not affect the already increased contractility of trachea from hyperoxia-exposed animals; the tensions achieved in hyperoxic tissues with and without ASA were similar to the hyperactive responses induced by ASA in tissues from animals reared in room air. Bronchi showed responses similar to those seen in tracheal segments. Thus, despite no apparent histological effect on the airway epithelium, hyperoxic exposure seems to increase airway smooth muscle contractility, is nonspecific for different constricting agents, and shows no regional differences in airway reactivity. C1 TRIPLER ARMY MED CTR,DEPT PEDIAT & CLIN INVEST,HONOLULU,HI 96859. FU NHLBI NIH HHS [HL-45220] NR 26 TC 15 Z9 15 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUN PY 1993 VL 74 IS 6 BP 2649 EP 2654 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA LL820 UT WOS:A1993LL82000006 PM 8365964 ER PT J AU BORMAN, WC HANSON, MA OPPLER, SH PULAKOS, ED WHITE, LA AF BORMAN, WC HANSON, MA OPPLER, SH PULAKOS, ED WHITE, LA TI ROLE OF EARLY SUPERVISORY EXPERIENCE IN SUPERVISOR PERFORMANCE SO JOURNAL OF APPLIED PSYCHOLOGY LA English DT Article ID JOB-PERFORMANCE; MODELS; SENIORITY; GOODNESS; VALIDITY; TESTS; FIT AB This research explores the role of early supervisory experience and cognitive ability in first-line supervisor performance. Similar to E L. Schmidt, J. E. Hunter, and A. N. Outerbridge's(1986) study of nonsupervisors, this research tested structural models hypothesizing relationships among supervisory experience, cognitive ability, supervisory knowledge and proficiency, and performance ratings, using a sample of 570 second-tour soldiers. The Schmidt et al. model with an additional ability - experience path provided the best fit. The significant ability --> experience path was interpreted as indicating that demonstrated ability contributes to soldiers being given the opportunity to obtain supervisory experience. Experience had a greater impact on supervisor proficiency than on superviSor knowledge. Ability had a greater impact on supervisor knowledge than on proficiency. Discussion focuses on the personal characteristics that might be involved in being assigned supervisory responsibilities. C1 PERSONNEL DECIS RES INST,MINNEAPOLIS,MN. AMER INST RES,WASHINGTON,DC. HUMAN RESOURCES RES ORG,ALEXANDRIA,VA. USA,RES INST,ALEXANDRIA,VA. RP BORMAN, WC (reprint author), UNIV S FLORIDA,DEPT PSYCHOL,BEH 339,TAMPA,FL 33620, USA. NR 22 TC 52 Z9 53 U1 1 U2 12 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0021-9010 J9 J APPL PSYCHOL JI J. Appl. Psychol. PD JUN PY 1993 VL 78 IS 3 BP 443 EP 449 PG 7 WC Psychology, Applied; Management SC Psychology; Business & Economics GA LH161 UT WOS:A1993LH16100011 ER PT J AU ARROYO, CM FELICIANO, F KOLB, DL KEELER, JR MILLETTE, SR STOTTS, RR AF ARROYO, CM FELICIANO, F KOLB, DL KEELER, JR MILLETTE, SR STOTTS, RR TI AUTOIONIZATION REACTION OF PHOSGENE (OCCL2) STUDIED BY ELECTRON-PARAMAGNETIC-RESONANCE SPIN-TRAPPING TECHNIQUES SO JOURNAL OF BIOCHEMICAL TOXICOLOGY LA English DT Article DE PHOSGENE; EPR; SPIN TRAPPING; CARBAMOYL MONOCHLORIDE RADICAL AB The reaction of phosgene with nitrone spin traps was investigated using electron paramagnetic resonance (EPR)/spin trapping techniques. Evidence for the intermediacy of a carbamoyl monochloride intermediate was obtained. Isotopic substitution of C-13-phosgene was employed to verify the hyperfine coupling constant assignments. The implications of these observations on pulmonary damage caused by inhalation of phosgene are mentioned. RP ARROYO, CM (reprint author), USA,MED RES INST CHEM DEF,ATTN SGRD UV-YY DR ARROYO,ABERDEEN PROVING GROUND,MD 21010, USA. NR 8 TC 6 Z9 8 U1 0 U2 2 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0887-2082 J9 J BIOCHEM TOXICOL JI J. Biochem. Toxicol. PD JUN PY 1993 VL 8 IS 2 BP 107 EP 110 DI 10.1002/jbt.2570080208 PG 4 WC Toxicology SC Toxicology GA LL374 UT WOS:A1993LL37400007 PM 8394937 ER PT J AU FIGUEROA, JA JACKSON, JG MCGUIRE, WL KRYWICKI, RF YEE, D AF FIGUEROA, JA JACKSON, JG MCGUIRE, WL KRYWICKI, RF YEE, D TI EXPRESSION OF INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS IN HUMAN BREAST-CANCER CORRELATES WITH ESTROGEN-RECEPTOR STATUS SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE IGFS; CELL GROWTH; BREAST CANCER CELL LINES; TUMOR BIOLOGY; HORMONAL REGULATION ID IGF-I; MOLECULAR-CLONING; CELLS; IDENTIFICATION; SERUM; SECRETION; CARCINOMA; INHIBITOR; RAT AB The insulin-like growth factors (IGFs) have been implicated in the growth regulation of human breast cancer. Since the IGFs are associated with specific binding proteins (IGFBPs) which may modulate receptor/ligand interactions, production of IGFBPs by breast cancer cells could alter their IGF-dependent growth. This study examined the expression of IGFBPs 4, 5, and 6 in eight breast cancer cell lines (BCCLs) using ribonuclease (RNase) protection assays. IGFBP-4 mRNA was detected in all BCCLs studied. IGFBP-5 expression was higher in estrogen receptor (ER) positive cells, while IGFBP-6 mRNA was detected in only two ER negative BCCLs. We also found that E2 treatment enhanced the expression of IGFBPs 2, 4, and 5 in T47-D cells. We next studied IGFBP mRNA expression in 40 primary breast tumors. All tumors expressed mRNA for IGFBPs 2-6 but none expressed IGFBP-1 message. IGFBP-3 expression was higher in ER negative tumors, while that of IGFBP-4 and -5 was higher in ER positive specimens. These differences were statistically significant (P < .05). Ligand blot analysis of tumor extracts confirmed the presence of IGFBPs in breast cancer tissues. Thus, differential IGFBP expression in ER positive and negative tumors suggests an important role for this protein in breast cancer biology. C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV MED ONCOL,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,ONCOL SERV,FT SAM HOUSTON,TX 78234. FU NCI NIH HHS [NRSA CA09434, R29CA52592] NR 35 TC 80 Z9 80 U1 0 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD JUN PY 1993 VL 52 IS 2 BP 196 EP 205 DI 10.1002/jcb.240520211 PG 10 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA LF871 UT WOS:A1993LF87100010 PM 7690042 ER PT J AU EAST, EW KIM, S AF EAST, EW KIM, S TI STANDARDIZING SCHEDULING DATA EXCHANGE SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT-ASCE LA English DT Article AB One of the major inefficiencies in the use of the critical path method (CPM) in the construction industry is the large number of proprietary and commercially available software scheduling systems. This inefficiency is due, in part, to the amount of data reentry required when progress data is exchanged between members of a project team. To solve this problem, the U.S. Army Corps of Engineers coordinated the development of a data-exchange standard with eight vendors, several construction managers, and Corps of Engineer field-office representatives. The standard was tested on a limited basis and has been officially required by the Corps of Engineers since March of 1990. To use the data-exchange features currently provided by software vendors, it is necessary for all participants in the data exchange to spend considerable time anticipating inconsistencies between software systems. A revised version of the format is expected to be released to vendors in early 1993. The revised version is expected to considerably reduce the time required by users to implement the exchange of project scheduling data. RP EAST, EW (reprint author), USA,CORPS ENGRS,CONSTR ENGRG RES LABS,CECER,FFC,POB 9005,CHAMPAIGN,IL 61826, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9364 J9 J CONSTR ENG M ASCE JI J. Constr. Eng. Manage.-ASCE PD JUN PY 1993 VL 119 IS 2 BP 215 EP 225 DI 10.1061/(ASCE)0733-9364(1993)119:2(215) PG 11 WC Construction & Building Technology; Engineering, Industrial; Engineering, Civil SC Construction & Building Technology; Engineering GA LE365 UT WOS:A1993LE36500003 ER PT J AU KUHRE, AN KESSLER, JR AF KUHRE, AN KESSLER, JR TI EFFECT OF MOISTURE ON THE APICAL SEAL OF LATERALLY CONDENSED GUTTA-PERCHA SO JOURNAL OF ENDODONTICS LA English DT Article ID OBTURATION TECHNIQUES; DYE-PENETRATION; ENTRAPPED AIR; INVITRO; LEAKAGE AB Eighty-five single-rooted human teeth were cleansed and shaped for obturation with gutta-percha and Proco-Sol root canal cement. Two of the three experimental groups had their canals contaminated with either 0.05 ml of NaOCl or saliva immediately prior to obturation. The remaining group of 25 teeth had dry canals prior to obturation. All teeth were obturated by the lateral condensation technique, covered with two coats of nail polish, immersed in India ink, and subjected to a vacuum for 15 min. The teeth were then cleared to allow visual assessment of the dye penetration through the apical seal. Positive and negative controls verified the experimental method. The recorded measurements were statistically analyzed and no significant differences were found among the groups. C1 ADV EDUC PROGRAM GEN DENT 2YR,FT BRAGG,NC. NR 16 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUN PY 1993 VL 19 IS 6 BP 277 EP 280 DI 10.1016/S0099-2399(06)80456-5 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LF359 UT WOS:A1993LF35900003 PM 8228746 ER PT J AU WANG, M ROSSI, C SCHMALJOHN, CS AF WANG, M ROSSI, C SCHMALJOHN, CS TI EXPRESSION OF NONCONSERVED REGIONS OF THE S-GENOME SEGMENTS OF 3 HANTAVIRUSES - EVALUATION OF THE EXPRESSED POLYPEPTIDES FOR DIAGNOSIS OF HEMORRHAGIC-FEVER WITH RENAL SYNDROME SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID KOREAN HEMORRHAGIC-FEVER; NEPHROPATHIA-EPIDEMICA VIRUS; HANTAAN VIRUS; ETIOLOGIC AGENT; BANK VOLES; PROTEINS; ANTIGEN; STRAINS; RATS AB Haemorrhagic fever with renal syndrome (HFRS) is a serious and often fatal disease caused by viruses in the Hantavirus genus of the family Bunyaviridae. We expressed the entire coding region of the small (S) genome segments of three serologically distinct hantaviruses as soluble proteins in Escherichia coli and evaluated the expressed nucleocapsid proteins (NPs) as antigens for diagnosis of HFRS. We also prepared novel diagnostic antigens by expressing truncated genes from which we deleted amino acid coding regions that were highly conserved among the three viruses. These antigens were analysed for their potential to detect and differentiate between antisera to various hantaviruses by ELISA. ELISA results obtained with HFRS patient sera or with sera from naturally or experimentally infected animals indicate that homologous antigens and antisera reacted to high titre. The truncated NPs were more specific than the complete NPs in distinguishing between possible aetiological agents of HFRS. Our findings demonstrate that prokaryotic expression of portions of the NPs of specific hantaviruses can be used to generate, readily and efficiently, large quantities of antigen that is both sensitive and specific in diagnostic assays for HFRS. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21702. NR 24 TC 38 Z9 50 U1 0 U2 1 PU SOC GENERAL MICROBIOLOGY PI READING PA HARVEST HOUSE 62 LONDON ROAD, READING, BERKS, ENGLAND RG1 5AS SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD JUN PY 1993 VL 74 BP 1115 EP 1124 DI 10.1099/0022-1317-74-6-1115 PN 6 PG 10 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA LG086 UT WOS:A1993LG08600019 PM 8099603 ER PT J AU SANCHEZ, JL TROFA, AF TAYLOR, DN KUSCHNER, RA DEFRAITES, RF CRAIG, SC RAO, MR CLEMENS, JD SVENNERHOLM, AM SADOFF, JC HOLMGREN, J AF SANCHEZ, JL TROFA, AF TAYLOR, DN KUSCHNER, RA DEFRAITES, RF CRAIG, SC RAO, MR CLEMENS, JD SVENNERHOLM, AM SADOFF, JC HOLMGREN, J TI SAFETY AND IMMUNOGENICITY OF THE ORAL, WHOLE-CELL RECOMBINANT B-SUBUNIT CHOLERA VACCINE IN NORTH-AMERICAN VOLUNTEERS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID FIELD TRIAL; ESCHERICHIA-COLI; VIBRIO-CHOLERAE; FOLLOW-UP; BANGLADESH; TOXIN; RESPONSES; DIARRHEA AB A newly formulated, oral, inactivated whole cell plus recombinant B subunit (WC/rBS) cholera vaccine was evaluated in US military personnel. In the first study, 74 subjects were given two doses 14 days apart. In the second study, 186 subjects were randomized into four groups; two groups received vaccine with either full (4 g) or half (2 g) strength bicarbonate buffer, and two groups received either full or half strength buffer without vaccine. Mild gastrointestinal symptoms were associated with full buffer (P = .02) but not with the vaccine. In the first study, 36% of all subjects and 55% with low prevaccination titers (<1:40) had a greater-than-or-equal-to 2-fold rise in vibriocidal antibody level; >80% of subjects developed a 4-fold rise in anti-cholera toxin (CT) titers. Post-vaccination IgA and IgG anti-CT titers were approximately 1.5-fold higher among persons receiving full strength buffer (P = .05). The WC/rBS vaccine is safe and immunogenic in North Americans, although some mild gastrointestinal symptoms occur with the high concentration of buffer necessary to protect the B subunit from gastric acid denaturation. Prior immunity to cholera conferred by parenteral vaccine decreased vibriocidal antibody response. C1 WALTER REED ARMY INST RES,DEPT ADV PREVENT MED,DIV PREVENT MED,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT ENTER INFECT,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. NICHHD,DIV PREVENT RES,BETHESDA,MD 20892. GOTHENBURG UNIV,DEPT MED MICROBIOL & IMMUNOL,S-41124 GOTHENBURG,SWEDEN. RP SANCHEZ, JL (reprint author), WALTER REED ARMY INST RES,DEPT FIELD STUDIES,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 15 TC 45 Z9 46 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUN PY 1993 VL 167 IS 6 BP 1446 EP 1449 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA LD694 UT WOS:A1993LD69400031 PM 8501336 ER PT J AU SCHULZ, DE AF SCHULZ, DE TI THE UNITED-STATES AND CUBA - FROM A STRATEGY OF CONFLICT TO CONSTRUCTIVE ENGAGEMENT SO JOURNAL OF INTERAMERICAN STUDIES AND WORLD AFFAIRS LA English DT Article RP SCHULZ, DE (reprint author), USA,COLL WAR,INST STRATEG STUDIES,WASHINGTON,DC 20310, USA. NR 16 TC 1 Z9 1 U1 0 U2 0 PU UNIV MIAMI PI CORAL GABLES PA J INTERAMER STUD WORLD AFF PO BOX 248134, CORAL GABLES, FL 33124 SN 0022-1937 J9 J INTERAM STUD WORLD JI J. Interam. Stud. World Aff. PD SUM PY 1993 VL 35 IS 2 BP 81 EP 102 DI 10.2307/165945 PG 22 WC Area Studies; International Relations; Political Science SC Area Studies; International Relations; Government & Law GA LW194 UT WOS:A1993LW19400003 ER PT J AU ADERA, T DONAHUE, AM MALIT, BD GAYDOS, JC AF ADERA, T DONAHUE, AM MALIT, BD GAYDOS, JC TI ASSESSMENT OF THE PROPOSED DRAFT AMERICAN NATIONAL STANDARD METHOD FOR EVALUATING THE EFFECTIVENESS OF HEARING CONSERVATION PROGRAMS SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID NOISE; WORKERS; AGE AB Using audiometric data, this study assessed the Draft American National Standard ANSI S12.13-1991 (DANS) method for evaluating the effectiveness of hearing conservation programs by comparing it against a standard epidemiologic method. Although the hearing conservation program of the study population was rated as ''acceptable'' (scale: acceptable, marginal, unacceptable) using the DANS method, the epidemiologic method found a 130% increased risk of hearing loss (relative risk = 2.3, 95% confidence interval = 0.8 to 6.5). In addition, study workers who were excluded from analyses for failing to comply with the DANS criteria were found to be at significantly increased risk of hearing loss (relative risk = 9.1, 95% confidence interval = 3.4 to 24.2). These data indicate that the DANS method may overestimate the effectiveness of hearing conservation programs and systematically exclude workers at high risk of hearing loss from analyses. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMET,BETHESDA,MD 20814. USA,ENVIRONM HYG AGCY,ABERDEEN PROVING GROUND,MD 21010. NR 36 TC 9 Z9 11 U1 1 U2 3 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 1993 VL 35 IS 6 BP 568 EP 573 DI 10.1097/00043764-199306000-00012 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA LG735 UT WOS:A1993LG73500008 PM 8331436 ER PT J AU KNAPIK, J ANG, P REYNOLDS, K JONES, B AF KNAPIK, J ANG, P REYNOLDS, K JONES, B TI PHYSICAL-FITNESS, AGE, AND INJURY INCIDENCE IN INFANTRY SOLDIERS SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID EXERCISE; RISKS; POPULATIONS; BENEFITS AB Injuries are a common occurrence in young, active civilian and military populations. This study examined injury incidence and the association Of musculoskeletal injuries with age and physical fitness in soldiers. Subjects were a cohort of 298 male soldiers assigned to an infantry battalion in Alaska. The soldiers' ages were obtained from the battalion records and their physical fitness was assessed from 2-mile run times, sit-ups, and push-ups. Injuries were documented from a retrospective review of the soldiers' medical records for a 6-month period (October to March) before the fitness testing. Fifty-one percent of the soldiers suffered one or more injuries. The most common injury diagnosis was musculoskeletal pain, followed by strains, sprains, and cold-related injuries. Soldiers experienced a total of 212 separate injuries, which resulted in 1764 days of limited duty. The crude annualized injury rate was 142 injuries per 100 soldiers (one soldier could experience more than one type of injury). The proportion of soldiers injured decreased as age increased. Slower 2-mile run times and fewer sit-ups were associated with a higher incidence of musculoskeletal injuries. This study documents the injury incidence in infantry soldiers and identifies younger age and low physical fitness as potential risk factors for these injuries. RP KNAPIK, J (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT MED,NATICK,MA 01760, USA. NR 27 TC 103 Z9 105 U1 2 U2 10 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 1993 VL 35 IS 6 BP 598 EP 603 DI 10.1097/00043764-199306000-00017 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA LG735 UT WOS:A1993LG73500013 PM 8331441 ER PT J AU WEISMAN, LE ANTHONY, BF HEMMING, VG FISCHER, GW AF WEISMAN, LE ANTHONY, BF HEMMING, VG FISCHER, GW TI COMPARISON OF GROUP-B STREPTOCOCCAL HYPERIMMUNE GLOBULIN AND STANDARD INTRAVENOUSLY ADMINISTERED IMMUNE GLOBULIN IN NEONATES SO JOURNAL OF PEDIATRICS LA English DT Article ID LINKED IMMUNOSORBENT-ASSAY; OPSONIC ACTIVITY; HUMAN-IGG; ANTIBODY-LEVELS; IMMUNOGLOBULIN; SERUM; POLYSACCHARIDE; SPECIFICITY; ANTIGENS; INFANTS AB Standard intravenously administered immune globulin (IVIG) contains varying amounts of group B streptococcus (GBS) antibody. A GBS hyperimmune IVIG was produced by immunizing plasma donors. The GBS type-specific opsonic activity was greater-than-or-equal-to 90% in the hyperimmune IVIG at a 1280 dilution-1 versus at a 10 dilution-1 in standard IVIG. Suckling rat survival after GBS type-specific infection was 100% when the rats were treated with hyperimmune IVIG versus less-than-or-equal-to 20% with standard IVIG. To evaluate the effect of this product on GBS antibody levels and clinical toxic effects, we randomly administered either GBS hyperimmune IVIG, 500, 250, or 100 mg/kg, or standard IVIG, 500 mg/kg, to 20 neonates with suspected sepsis. No adverse effects were observed. Total and subclass serum IgG levels reflected only the dose; serum GBS type-specific IgG and opsonic activity reflected both the product and dose of IVIG administered. Standard IVIG did not significantly increase serum GBS type-specific IgG, whereas hyperimmune IVIG, 500 mg/kg, produced a fourfold rise for >6 weeks; more variable increases were observed after 250 and 100 mg/kg doses were given. Serum GBS type-specific opsonic activity correlated with serum GBS type-specific IgG levels (R2 = 0.74; p < 0.0001). Further studies of this or similar products will be necessary to determine whether GBS type-specific antibody improves the outcome of GBS-infected neonates. C1 WALTER REED ARMY MED CTR, DEPT PEDIAT, WASHINGTON, DC 20307 USA. UNIV CALIF LOS ANGELES, HARBOR SCH MED, DEPT PEDIAT, TORRANCE, CA 90509 USA. RP WEISMAN, LE (reprint author), UNIFORMED SERV UNIV HLTH SCI, DEPT PEDIAT, 4301 JONES BRIDGE RD, BETHESDA, MD 20814 USA. FU NIAID NIH HHS [R01-AI26257] NR 34 TC 14 Z9 14 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD JUN PY 1993 VL 122 IS 6 BP 929 EP 937 PG 9 WC Pediatrics SC Pediatrics GA LF552 UT WOS:A1993LF55200019 PM 8501574 ER PT J AU GUY, SC MCQUADE, MJ SCHEIDT, MJ MCPHERSON, JC ROSSMANN, JA VANDYKE, TE AF GUY, SC MCQUADE, MJ SCHEIDT, MJ MCPHERSON, JC ROSSMANN, JA VANDYKE, TE TI INVITRO ATTACHMENT OF HUMAN GINGIVAL FIBROBLASTS TO ENDOSSEOUS IMPLANT MATERIALS SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE FIBROBLASTS; TITANIUM; HYDROXYAPATITE; DENTAL IMPLANTS ID CONNECTIVE-TISSUE; TITANIUM IMPLANTS; DENTAL IMPLANTS; FIBRONECTIN; ADHESION; TOOTH; CELLS; DOGS AB IN RECENT YEARS, THE FOCUS of dental implant research has been the nature of the bone-implant interface associated with osseointegration, yet the transgingival portion of endosseous dental implants has received little attention. The purpose of this study was to determine the attachment of human gingival fibroblasts to three different implant materials: commercially pure titanium, non-porous hydroxyapatite, and porous hydroxyapatite. Cell attachment was quantified by radiolabeling gingival fibroblasts with tritiated thymidine and counting attached cells by liquid scintillation following incubation for periods of 20, 40, and 60 minutes. Additional studies coating implant surfaces with fibronectin were also performed. The nature of the implant material itself appeared to affect the number of attached cells. Determined on a surface area basis, fibroblast attachment was greatest to titanium followed by non-porous hydroxyapatite. Porous hydroxyapatite demonstrated the least amount of fibroblast attachment. When incubated with fibronectin at a concentration of 50 mug/ml, no increase in the number of cells attached to the various implant materials was observed. A small but statistically significant increase in the number of fibroblasts attached to porous hydroxyapatite at 40 minutes was observed when implant materials were pre-treated with fibronectin. C1 USA,FT DRUM,NY. BAYLOR UNIV,DALLAS,TX. USA,BERLIN,GERMANY. USA,DD EISENHOWER ARMY MED CTR,FT GORDON,GA. UNIV TEXAS,AUSTIN,TX 78712. EASTMAN DENT CTR,ROCHESTER,NY 14620. RP GUY, SC (reprint author), USA,PERIODONT RESIDENCY PROGRAM,DENTAC,FT GORDON,GA 30905, USA. NR 50 TC 35 Z9 35 U1 0 U2 1 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD JUN PY 1993 VL 64 IS 6 BP 542 EP 546 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LG977 UT WOS:A1993LG97700006 PM 8393107 ER PT J AU RETHAM, M AF RETHAM, M TI PERIODONTAL TERMINOLOGY SO JOURNAL OF PERIODONTOLOGY LA English DT Letter RP RETHAM, M (reprint author), USA,INST DENT RES,COLUMBIA,MD, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD JUN PY 1993 VL 64 IS 6 BP 583 EP 583 PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LG977 UT WOS:A1993LG97700013 PM 8336258 ER PT J AU BROWN, ND LEADER, H PHILLIPS, LR SMEJKAL, RM GORDON, RK CHIANG, PK AF BROWN, ND LEADER, H PHILLIPS, LR SMEJKAL, RM GORDON, RK CHIANG, PK TI SYNTHESIS AND ANTIMUSCARINIC ACTIVITY OF 2-[N-(ETHYL)-(N-BETA-HYDROXYETHYL)]AMINOETHYL 2,2-DIPHENYLPROPIONATE, A METABOLITE OF APROPHEN SO JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Article ID RECEPTOR AB The preparation of 2-[N-(ethyl)-(N-beta-hydroxyethyl)]amino-ethyl 2,2-diphenylpropionate (1), a metabolite of aprophen [2-diethylamineothyl 2,2-diphenylpropionate], is described. Hydrolysis of [2-(2-chloroethyl)ethylamino]ethyl acetate hydrochloride (2) in a basic solution, followed by acidic pH adjustment, gave the ethylcholineaziridinium ion (3) that upon treatment with 2,2-diphenylpropionic acid produced 1 in a 56% yield. Synthetic 1 was found to possess antimuscarinic activities, but was approximately 10-fold less potent than the parent compound aprophen. C1 US FDA,CTR BIOL EVALUAT & RES,DIV BIOCHEM & BIOPHYS,BETHESDA,MD 20014. ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. RP BROWN, ND (reprint author), WALTER REED ARMY INST RES,APPL BIOCHEM BRANCH,WASHINGTON,DC 20307, USA. NR 12 TC 0 Z9 0 U1 0 U2 1 PU AMER PHARMACEUTICAL ASSN PI WASHINGTON PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037 SN 0022-3549 J9 J PHARM SCI JI J. Pharm. Sci. PD JUN PY 1993 VL 82 IS 6 BP 563 EP 564 DI 10.1002/jps.2600820603 PG 2 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA LE459 UT WOS:A1993LE45900002 PM 8331525 ER PT J AU BERNSTEIN, SA STRICKLAND, RW LAZARUS, E AF BERNSTEIN, SA STRICKLAND, RW LAZARUS, E TI AXILLARY LYMPHADENOPATHY DUE TO SWANSON IMPLANTS SO JOURNAL OF RHEUMATOLOGY LA English DT Note DE SILICONE LYMPHADENOPATHY; SILACTIC ELASTOMERS; JOINT PROSTHESES; RHEUMATOID ARTHRITIS; FOREIGN BODY REACTION ID CONCOMITANT MALIGNANT-LYMPHOMA; SILICONE LYMPHADENOPATHY; PROSTHESES AB We describe a case of unilateral axillary lymphadenopathy in an elderly woman with a long history of rheumatoid arthritis, 7 years status post placement of Swanson silastic elastomer implants in her right hand with good surgical outcome and with no outward reason for adenopathy. Though there was concern for malignancy, pathologic evaluation of the lymph node revealed foreign body giant cells reacting to silastic from her hand implants and no evidence of malignancy. This is only the 10th such case reported, despite the number of implants placed. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. NR 15 TC 15 Z9 15 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO ON M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD JUN PY 1993 VL 20 IS 6 BP 1066 EP 1069 PG 4 WC Rheumatology SC Rheumatology GA LH112 UT WOS:A1993LH11200031 PM 8350316 ER PT J AU SPERLING, LC HEIMER, WL AF SPERLING, LC HEIMER, WL TI ANDROGEN BIOLOGY AS A BASIS FOR THE DIAGNOSIS AND TREATMENT OF ANDROGENIC DISORDERS IN WOMEN .2. SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID POLYCYSTIC-OVARY-SYNDROME; HORMONE BINDING GLOBULIN; DEHYDROEPIANDROSTERONE SULFATE; HIRSUTE WOMEN; 21-HYDROXYLASE DEFICIENCY; HYPERANDROGENIC WOMEN; CYPROTERONE-ACETATE; ORAL-CONTRACEPTIVES; TESTOSTERONE LEVELS; LATE-ONSET AB In the May 1993 issue of the JOURNAL we reviewed the basic science of androgen biology in women. We now discuss the evaluation of suspected hyperandrogenism and the therapeutic modalities available. RP SPERLING, LC (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 119 TC 17 Z9 18 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JUN PY 1993 VL 28 IS 6 BP 901 EP 916 DI 10.1016/0190-9622(93)70129-H PG 16 WC Dermatology SC Dermatology GA LD941 UT WOS:A1993LD94100001 PM 8496453 ER PT J AU LESER, CP AF LESER, CP TI ORGANIZING DENTAL STUDY CLUBS - EDUCATION FOR BETTER PATIENT-CARE SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Article AB Direction, definition, dedication and design are the four requirements to establish a study club. Study clubs provide incentives for personal and professional growth, leading to better patient care. C1 WILLIAM BEAUMONT ARMY MED CTR,FT BLISS,TX. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER DENTAL ASSN PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 SN 0002-8177 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD JUN PY 1993 VL 124 IS 6 BP 111 EP 114 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LG409 UT WOS:A1993LG40900016 PM 8505444 ER PT J AU CHOW, E WIRTZ, RA SCOTT, TW AF CHOW, E WIRTZ, RA SCOTT, TW TI IDENTIFICATION OF BLOOD MEALS IN AEDES-AEGYPTI BY ANTIBODY SANDWICH ENZYME-LINKED-IMMUNOSORBENT-ASSAY SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID ELISA; CULICIDAE; DIPTERA; KENYA AB A comparative study of 3 ELISA protocols was performed for host blood meal identification in Aedes aegypti. In the sandwich-B ELISA, which used a combination of heavy and heavy + light chain conjugates, specificity was improved to such a degree that conjugates no longer required cross-adsorption with heterologous sera. Using the sandwich-B assay, human blood meals in laboratory reared Ae. aegypti could be detected longer after feeding (100% at 32 h and 80% at 42 h) than with a direct assay (100% at 20 h). Efficacy of the sandwich-B and direct ELISAs in field analyses was studied in parallel using 80 field collected mosquitoes from Thailand. The sandwich-B assay was superior (88% detection rate) to the direct assay (41% detection rate) and was thus selected as the method of choice for future field studies. C1 UNIV MARYLAND,CTR AGR BIOTECHNOL,COLL PK,MD 20742. WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. RP CHOW, E (reprint author), UNIV MARYLAND,DEPT ENTOMOL,COLL PK,MD 20742, USA. FU NIAID NIH HHS [AI-22119, AI-26787] NR 15 TC 48 Z9 52 U1 0 U2 2 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 1993 VL 9 IS 2 BP 196 EP 205 PG 10 WC Entomology SC Entomology GA LL221 UT WOS:A1993LL22100015 PM 8350077 ER PT J AU BECKER, WK SHIPPEE, RL MCMANUS, AT MASON, AD PRUITT, BA AF BECKER, WK SHIPPEE, RL MCMANUS, AT MASON, AD PRUITT, BA TI KINETICS OF NITROGEN-OXIDE PRODUCTION FOLLOWING EXPERIMENTAL THERMAL-INJURY IN RATS SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 1992 ANNUAL SESSION OF THE AMERICAN ASSOC FOR THE SURGERY OF TRAUMA CY SEP 17-19, 1992 CL LOUISVILLE, KY SP AMER ASSOC SURG TRAUMA ID MAMMALIAN NITRATE BIOSYNTHESIS; NITRIC-OXIDE; L-ARGININE; HYPERMETABOLIC RESPONSE; KUPFFER CELLS; MACROPHAGES; PRECURSOR; ENDOTOXIN; SYNTHASE; RELEASE AB Nitric oxide is biosynthesized from the amino acid L-arginine by the enzyme nitric oxide synthase. Nitric oxide is a vasodilator, a neurotransmitter, and may modulate immune function. The experiments presented here were performed to determine whether the synthesis of nitric oxide is increased following experimental burn injury in rats. After a 30% total body surface area burn in 300-g Lewis rats, the urinary output of nitrate, a stable metabolite of nitric oxide, was significantly increased for 8 days postburn compared with that in sham-burned control rats. The origin of the urinary nitrate from L-arginine was demonstrated by administering the stable isotope N-15(2)-guanido-arginine to burned and sham-burned rats and observing an immediate enrichment of N-15 in nitrate. The amount of administered N-15 recovered as (NO3)-N-15 was < 1% of the administered arginine isotope in both the burned and unburned rats; the recovery of the isotope increased tenfold over baseline recovery in burned rats. The arginine analog N-monomethyl-arginine, an inhibitor of the enzyme nitric oxide synthase, blocked the postburn rise in urinary NO3 output in burned rats, but did not completely inhibit the output of NO3 in burn wound-infected rats. Experimental burn injury in rats results in an increase in L-arginine-dependent nitric oxide production and urinary nitrate output. RP BECKER, WK (reprint author), USA,INST SURG RES,LIB RES,FT SAM HOUSTON,TX 78234, USA. NR 43 TC 57 Z9 60 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 1993 VL 34 IS 6 BP 855 EP 862 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA LL115 UT WOS:A1993LL11500017 PM 8315681 ER PT J AU MOUL, JW BISHOFF, JT THEUNE, SM CHANG, EH AF MOUL, JW BISHOFF, JT THEUNE, SM CHANG, EH TI ABSENT RAS GENE-MUTATIONS IN HUMAN ADRENAL-CORTICAL NEOPLASMS AND PHEOCHROMOCYTOMAS SO JOURNAL OF UROLOGY LA English DT Article DE ADRENAL NEOPLASMS; PHEOCHROMOCYTOMA; GENES, RAS; POLYMERASE CHAIN REACTION; CARCINOMA ID POLYMERASE CHAIN-REACTION; PARAFFIN-EMBEDDED TISSUES; HUMAN NEURO-BLASTOMA; C-KI-RAS; ENDOCRINE NEOPLASIA; HUMAN NEUROBLASTOMAS; TUMOR-CELLS; CELLULAR ONCOGENE; AMPLIFIED DNA; WILMS TUMOR AB A variety of human tumors have been studied for ras mutations to date. However, little is known about the prevalence and significance of ras gene activation in adrenal neoplasms. Recently, a study of 10 primary human pheochromocytomas found no evidence for ras mutations. To our knowledge no survey of ras mutations in adrenocortical neoplasms has been reported. Therefore, we analyzed deoxyribonucleic acid (DNA) from 17 archival tumors (8 adrenocortical carcinomas, 6 pheochromocytomas, 2 adrenal adenomas, 1 aldosteronoma, 2 fresh pheochromocytomas and 1 fresh benign adrenal gland) for activating mutations at the 12, 13 and 61 codons of N-ras, H-ras and K-ras. DNA was extracted from archival tissues using 3 different methods: a simplified boiling method, a proteinase-K-phenol chloroform extraction and a novel heat-stable protease Thermus rt41A technique. The boiling and heat-stable protease methods provided for more consistent polymerase chain reaction amplifications than the more laborious phenol chloroform method. This heat-stable protease Thermus rt41A method had not been reported previously for use in archival DNA extraction. Polymerase chain reaction amplified the ras gene regions of interest, and mutations were screened by mutation-specific oligonucleotide probe hybridization of Southern and slot blots. Polymerase chain reaction-generated mutation-specific positive and negative controls were used in the hybridization protocol. With these controlled conditions no definite mutations were detected at codons 12, 13 or 61 of N, H or K-ras. Ras activation via point mutations at these codons rarely, if ever, occurs in adrenal neoplasms. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,UROL SECT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP MOUL, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 49 TC 41 Z9 41 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUN PY 1993 VL 149 IS 6 BP 1389 EP 1394 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA LE819 UT WOS:A1993LE81900002 PM 8501773 ER PT J AU FERNANDEZ, JA CAIN, DR RIVERA, LR KREUTZMAN, RJ AF FERNANDEZ, JA CAIN, DR RIVERA, LR KREUTZMAN, RJ TI RIBBON DRESSING FOR CIRCUMCISION SO JOURNAL OF UROLOGY LA English DT Note DE PENIS; CIRCUMCISION; BANDAGES RP FERNANDEZ, JA (reprint author), USA,CTR AVIAT MED,DEPT UROL SURG,FT RUCKER,AL 36360, USA. NR 2 TC 2 Z9 2 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUN PY 1993 VL 149 IS 6 BP 1501 EP 1502 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA LE819 UT WOS:A1993LE81900035 PM 8501795 ER PT J AU BLANK, S AF BLANK, S TI DIPLOMACY AT AN IMPASSE - RUSSIA AND JAPAN IN A NEW ASIA SO KOREAN JOURNAL OF DEFENSE ANALYSIS LA English DT Article AB The cancellation of President Yeltsin's state visit to Japan in the fall of 1991 and continuing bilateral discussions with Japan testify to the existence of an impasse in Russo-Japanese relationships. This article concentrates on the Russian diplomatic view of Japan and analyzes the reasons for the failure of Russian diplomacy to devise a modus vivendi for a dialogue with Japan on outstanding issues such as the Kurile Islands. The article examines the institutional rivalries over Russian foreign policy that engulfed the Ministry of Foreign Affairs in a controversy it could not win, and thereby hobbled effective policy-making. But it goes beyond that analysis to examine some of the basic preconceptions of Russian diplomacy's approach to Japan and what those perspectives tell us about the nature of Russia's new position in Asia and about changes in the overall Asian state system. As a result of this analysis the author finds that despite the sincere effort of the Ministry to have a genuine dialogue with Japan, its approach is still marred by continuities from the Soviet period and fundamental misconceptions about the current direction of Japanese policy. The approach taken by the Ministry in its diplomacy before the visit already contained serious flaws not yet overcome in the Russian approach to the Asia-Pacific and to Japan in particular. And since the failure of Yeltsin's visit it appears that both countries' policies have hardened, with Russia's 99-year leases on the Kuriles and major Japanese security initiatives in Southeast Asia. Evidently both sides are looking for alternatives to serious bilateral dialogue, a situation that can only continue to prevent Russia from playing any big new Asia-Pacific role. RP BLANK, S (reprint author), USA,WAR COLL,INST STRATEG STUDIES,CARLISLE,PA 17013, USA. NR 31 TC 1 Z9 1 U1 0 U2 2 PU KOREAN INST DEFENSE ANALYSES PI SEOUL PA OFFICE RESEARCH COOPERATION, PO BOX 250, SEOUL 130-650, SOUTH KOREA SN 1016-3271 J9 KOREAN J DEF ANAL JI Korean J. Def. Anal. PD SUM PY 1993 VL 5 IS 1 BP 141 EP 164 PG 24 WC International Relations SC International Relations GA MN933 UT WOS:A1993MN93300008 ER PT J AU DOOLEY, DP AF DOOLEY, DP TI TREATMENT OF OTOSYPHILIS SO LARYNGOSCOPE LA English DT Letter RP DOOLEY, DP (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 8 TC 0 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD JUN PY 1993 VL 103 IS 6 BP 711 EP 712 PG 2 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA LG818 UT WOS:A1993LG81800024 PM 8502109 ER PT J AU LEIBY, DA SCHREIBER, RD NACY, CA AF LEIBY, DA SCHREIBER, RD NACY, CA TI IFN-GAMMA PRODUCED IN-VIVO DURING THE 1ST 2 DAYS IS CRITICAL FOR RESOLUTION OF MURINE LEISHMANIA-MAJOR INFECTIONS SO MICROBIAL PATHOGENESIS LA English DT Note DE IFN-GAMMA; TNF-ALPHA; LEISHMANIA-MAJOR; INFECTION; ANTI-CYTOKINE MAB ID TUMOR-NECROSIS-FACTOR; NATURAL-KILLER-CELLS; CUTANEOUS LEISHMANIASIS; MONOCLONAL-ANTIBODIES; INTERFERON-PRODUCTION; HOST-RESISTANCE; ACTIVATION; SUBSETS; MICE; CYTOKINES C1 WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110. RI Schreiber, Robert/A-1276-2013 OI Schreiber, Robert/0000-0001-6311-0432 NR 25 TC 14 Z9 14 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD JUN PY 1993 VL 14 IS 6 BP 495 EP 500 DI 10.1006/mpat.1993.1049 PG 6 WC Immunology; Microbiology SC Immunology; Microbiology GA LN993 UT WOS:A1993LN99300009 PM 8412622 ER PT J AU HERNICZ, CB AF HERNICZ, CB TI THE CIVIL-RIGHTS-ACTS-OF-1991 - FROM CONCILIATION TO LITIGATION - HOW CONGRESS DELEGATES LAWMAKING TO THE COURTS SO MILITARY LAW REVIEW LA English DT Article ID SUPREME-COURT; STATUTORY INTERPRETATION; CONFIRMATION; DECISIONS; HISTORY RP HERNICZ, CB (reprint author), USA,JUDGE ADVOCATE GEN SCH,CHARLOTTESVILLE,VA 22901, USA. NR 106 TC 5 Z9 5 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1993 VL 141 BP 1 EP 82 PG 82 WC Law SC Government & Law GA NC013 UT WOS:A1993NC01300001 ER PT J AU BORCH, FL AF BORCH, FL TI COLD-WAR CASUALITY - HOFMANN,GF SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,USA COMMAND & GENERAL STAFF COLL,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1993 VL 141 BP 229 EP 231 PG 3 WC Law SC Government & Law GA NC013 UT WOS:A1993NC01300006 ER PT J AU BLOUNT, BW KROBER, MS GLOYD, SS KOZAKOWSKI, M CASEY, L AF BLOUNT, BW KROBER, MS GLOYD, SS KOZAKOWSKI, M CASEY, L TI NUTRITIONAL-STATUS OF RURAL BOLIVIAN CHILDREN SO MILITARY MEDICINE LA English DT Article AB While providing health care in rural Bolivia, 349 children under 4 years old were seen. Height and weight were measured and demographic data obtained. The purpose was to describe the prevalence of malnutrition and its associated socioeconomic factors. The sample included Mataco Indians and Bolivians of European or of mixed descent. Using international standards, 21% of the children had weight below the fifth percentile for age; 27% had height below the fifth percentage for age; 17% were below the fifth percentile for weight/height. Malnutrition was more common in younger children (peak prevalence in 1-2 year olds). Malnutrition was associated with race and water source, but not with family size, literacy, immunizations, meals per day, or deaths in family. Attempts to improve nutrition should focus on the youngest children. RP BLOUNT, BW (reprint author), EISENHOWER ARMY MED CTR,DEPT FAMILY PRACTICE,FT GORDON,GA 30905, USA. NR 0 TC 4 Z9 4 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1993 VL 158 IS 6 BP 367 EP 370 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA LG142 UT WOS:A1993LG14200009 PM 8361590 ER PT J AU CANCIO, L AF CANCIO, L TI CHEMICAL CASUALTY DECONTAMINATION SO MILITARY MEDICINE LA English DT Letter RP CANCIO, L (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1993 VL 158 IS 6 BP A5 EP A5 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA LG142 UT WOS:A1993LG14200006 ER PT J AU MCCANN, UD PENETAR, DM SHAHAM, Y THORNE, DR SING, HC THOMAS, ML GILLIN, JC BELENKY, G AF MCCANN, UD PENETAR, DM SHAHAM, Y THORNE, DR SING, HC THOMAS, ML GILLIN, JC BELENKY, G TI EFFECTS OF CATECHOLAMINE DEPLETION ON ALERTNESS AND MOOD IN RESTED AND SLEEP-DEPRIVED NORMAL VOLUNTEERS SO NEUROPSYCHOPHARMACOLOGY LA English DT Article DE SLEEP DEPRIVATION; ALERTNESS; MOOD; CATECHOLAMINES; MONOAMINES ID CENTRAL NERVOUS-SYSTEM; REM-SLEEP; DEPRESSED-PATIENTS; RAT-BRAIN; MHPG EXCRETION; DEPRIVATION; DISORDERS; NOREPINEPHRINE; METABOLISM; ILLNESS AB Alpha-methyl-para-tyrosine (AMPT), a tyrosine hydroxylase inhibitor, was used to evaluate the physiologic role of central nervous system catecholamines in modulating alertness and mood. Forty healthy males were randomized to one of four conditions: AMPT in a rested condition; AMPT plus 40.5 hours of total sleep deprivation; placebo plus sleep deprivation; or placebo in a rested condition. Repeated measures of alertness and mood revealed that treatment with AMPT or sleep deprivation increased sleepiness, and combined treatment produced greater sleepiness than either treatment alone. In contrast, although combined treatment with AMPT and sleep deprivation led to large increases in negative mood, neither treatment alone produced consistent mood changes. These findings are consistent with the view that sleep deprivation is associated with decreased functional catecholamine neurotransmission. Furthermore, mood effects following sleep deprivation plus AMPT suggest that catecholamines may be involved in mood changes during sleep deprivation. C1 WALTER REED ARMY INST RES,DEPT BEHAV BIOL,WASHINGTON,DC 20307. VET ADM MED CTR,PSYCHIAT SERV,SAN DIEGO,CA 92161. CONCORDIA UNIV,DEPT PSYCHOL,MONTREAL H3G 1M8,QUEBEC,CANADA. UNIV CALIF SAN DIEGO,DEPT PSYCHIAT,SAN DIEGO,CA 92103. RP MCCANN, UD (reprint author), NIMH,ANXIETY & AFFECT DISORDERS SECT,BLDG 10,ROOM 3S-239,BETHESDA,MD 20892, USA. RI shaham, yavin/G-1306-2014 NR 47 TC 34 Z9 37 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0893-133X J9 NEUROPSYCHOPHARMACOL JI Neuropsychopharmacology PD JUN PY 1993 VL 8 IS 4 BP 345 EP 356 PG 12 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA LD161 UT WOS:A1993LD16100005 PM 8099791 ER PT J AU MCDONOUGH, JH SHIH, TM AF MCDONOUGH, JH SHIH, TM TI PHARMACOLOGICAL MODULATION OF SOMAN-INDUCED SEIZURES SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS LA English DT Review DE SOMAN; ORGANOPHOSPHORUS COMPOUNDS; NERVE AGENTS; SEIZURES; EEG ACTIVITY; ANTICHOLINERGIC COMPOUNDS; BENZODIAZEPINES; DIAZEPAM; NMDA ANTAGONISTS; MK-801; ANTICONVULSANTS; HI-6; EXCITATORY AMINO ACIDS ID GAMMA-AMINOBUTYRIC ACID; INDUCED CONVULSIONS; NERVE AGENTS; RAT-BRAIN; ANTICONVULSANT ACTIONS; STATUS EPILEPTICUS; CHOLINE LEVELS; DIAZEPAM; MK-801; ACETYLCHOLINE AB Anticholinergics, benzodiazepines and N-methyl-D-aspartate (NMDA) antagonists have been shown to modulate the expression of nerve agent-induced seizures. This study examined whether the anticonvulsant actions of these drugs varied depending on the duration of prior seizure activity. Rats implanted with electrodes to record electroencephalographic (EEG) activity were pretreated with the oxime HI-6 (125 mg/kg, IP) to prolong survival, and then challenged with a convulsant dose of the nerve agent soman (180 mug/kg, SC); treatment compounds (scopolamine, diazepam, MK-801, atropine, benactyzine, and trihexyphenidyl) were delivered IV at specific times after seizure onset. Both diazepam and MK-801 displayed a similar profile of activity: At both short or long times after seizure initiation the anticonvulsant efficacy of each drug remained the same. Diazepam, and especially MK-801, enhanced the lethal actions of soman by potentiating the respiratory depressant effects of the agent; scopolamine given prior to diazepam or MK-801 protected against the respiratory depression. Scopolamine and atropine showed a dose- and time-dependent effectiveness; the longer the seizure progressed the higher the dose of drug required to terminate the seizure, with eventual loss of anticonvulsant activity if the seizure had progressed for 40 min. In contrast, benactyzine and trihexyphenidyl showed a third profile of activity: There was a smaller increase in drug dosage required for anticonvulsant activity as seizure duration increased, and both drugs could terminate seizures that had progressed for 40 min. The early anticonvulsant action of anticholinergics is interpreted as a specific effect that blocks the primary cholinergic excitatory drive that initiates, and first maintains, nerve agent seizures. If allowed to progress, the seizure activity itself recruits excitatory neurotransmitter systems (i.e., NMDA) that eventually maintain the seizure independent of the initial cholinergic drive. This is indicated by the eventual ineffectiveness of scopolamine and atropine as the duration of the seizure progresses. Diazepam and MK-801 appear to act to moderate nerve agent seizures by enhancing inhibitory activity (diazepam) or dampening the secondarily activated noncholinergic excitatory system (MK-801). Benactyzine and trihexyphenidyl represent compounds that possibly have both anticholinergic and NMDA antagonistic properties. RP MCDONOUGH, JH (reprint author), USA,CHEM DEF RES INST,BIOCHEM PHARMACOL BRANCH,ATTN SGRD UV PB,ABERDEEN PROVING GROUND,MD 21010, USA. NR 63 TC 159 Z9 160 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0149-7634 J9 NEUROSCI BIOBEHAV R JI Neurosci. Biobehav. Rev. PD SUM PY 1993 VL 17 IS 2 BP 203 EP 215 DI 10.1016/S0149-7634(05)80151-4 PG 13 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA LC892 UT WOS:A1993LC89200004 PM 8515903 ER PT J AU ARMONDA, RA FLECKENSTEIN, JM BRANDVOLD, B ONDRA, SL HAINES, SJ AF ARMONDA, RA FLECKENSTEIN, JM BRANDVOLD, B ONDRA, SL HAINES, SJ TI CRYPTOCOCCAL SKULL INFECTION - A CASE-REPORT WITH REVIEW OF THE LITERATURE SO NEUROSURGERY LA English DT Note DE AMPHOTERICIN-B; CT; CRYPTOCOCCOSIS; FLUCYTOSINE; OSTEOMYELITIS; SKULL LESION AB A CASE OF cryptococcal osteomyelitis of the skull is presented. The patient was an immunocompetent host with skull and skin involvement without central nervous system or pulmonary extension. The radiographic findings are reviewed to include skull films, bone scan, and computed tomographic and magnetic resonance imaging scans. The patient underwent surgical debridement of the lesion as well as systemic medical therapy with amphotericin B and flucytosine. The medical and surgical therapy for such lesions is reviewed. Surgical intervention is emphasized for the removal of bony sequestrum and nonviable bone while maintaining an intact dura. C1 WALTER REED ARMY MED CTR,DEPT NEUROSURG,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT INFECT DIS,WASHINGTON,DC 20307. RI Haines, Stephen/L-3209-2013; OI Haines, Stephen/0000-0002-4263-0268; Fleckenstein, James/0000-0002-1148-697X NR 19 TC 22 Z9 22 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0148-396X J9 NEUROSURGERY JI Neurosurgery PD JUN PY 1993 VL 32 IS 6 BP 1034 EP 1036 PG 3 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA LE907 UT WOS:A1993LE90700028 PM 8327080 ER PT J AU YAN, Y AF YAN, Y TI ATTRACTORS AND DIMENSIONS FOR DISCRETIZATIONS OF A WEAKLY DAMPED SCHRODINGER-EQUATION AND A SINE-GORDEN EQUATION SO NONLINEAR ANALYSIS-THEORY METHODS & APPLICATIONS LA English DT Article DE SCHRODINGER EQUATION; SINE-GORDEN EQUATION; FINITE DIFFERENCE; ATTRACTOR; HAUSDORFF DIMENSION RP YAN, Y (reprint author), UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455, USA. NR 3 TC 22 Z9 27 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0362-546X J9 NONLINEAR ANAL-THEOR JI Nonlinear Anal.-Theory Methods Appl. PD JUN PY 1993 VL 20 IS 12 BP 1417 EP 1452 DI 10.1016/0362-546X(93)90168-R PG 36 WC Mathematics, Applied; Mathematics SC Mathematics GA LK658 UT WOS:A1993LK65800003 ER PT J AU BASS, JW STEELE, RW WITTLER, RR WEISSE, ME BELL, V HEISSER, AH BRIEN, JH FAJARDO, JE WASSERMAN, GM VINCENT, JM JONES, RG BANKS, RA KROBER, MS EITZEN, EM KOTCHMAR, GS GREENWALL, K BAUGH, JR ROBB, ML MASON, JD AF BASS, JW STEELE, RW WITTLER, RR WEISSE, ME BELL, V HEISSER, AH BRIEN, JH FAJARDO, JE WASSERMAN, GM VINCENT, JM JONES, RG BANKS, RA KROBER, MS EITZEN, EM KOTCHMAR, GS GREENWALL, K BAUGH, JR ROBB, ML MASON, JD TI ANTIMICROBIAL TREATMENT OF OCCULT BACTEREMIA - A MULTICENTER COOPERATIVE STUDY SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE OCCULT BACTEREMIA; BACTEREMIA; FEVER; ANTIMICROBIAL TREATMENT; LEUKOCYTOSIS ID FEBRILE CHILDREN; OUTPATIENT BACTEREMIA; CEFTRIAXONE; TEMPERATURE; BLOOD; RISK; AGE AB This prospective multicenter study was conducted to define more clearly clinical and laboratory criteria that predict a strong probability of occult bacteremia and to evaluate the effect of empiric broad spectrum antimicrobial treatment of these children. Children 3 to 36 months old with fever greater-than-or-equal-to 40-degrees-C (104-degrees-F) or, greater-than-or-equal-to 39.5-degrees-C (103-degrees-F) with white blood cells (WBC) greater-than-or-equal-to 15 x 10(9)/liter, and no focus of infection had blood cultures obtained and were randomized to treatment with oral amoxicillin/potassium clavulanate or intramuscular ceftriaxone. Sixty of 519 (11.6%) study patients had positive blood cultures: Streptococcus pneumoniae, 51; Haemophilus influenzae b, 6; Neisseria meningitidis, 2; and Group B Streptococcus, 1. Subgroups of high risk were identified as fever greater-than-or-equal-to 39.5-degrees-C and WBC greater-than-or-equal-to 15 x 10(9)/liter, 55 of 331 or 16.6% positive with increasing incidence of positive culture with increasing increments of degrees of leukocytosis to WBC greater-than-or-equal-to 30 x 10(9)/liter where 9 of 21 or 42.9% were positive. Subgroups of significantly lower risk were identified as fever greater-than-or-equal-to 39.5-degrees-C and WBC <15 x 10(9)/liter, 5 of 182 or 2.7% positive and those with WBC <10 x 10(9)/liter, 0 of 99 or 0.0% positive. Children with positive cultures who received ceftriaxone were nearly all afebrile after 24 hours whereas a significant number who received amoxicillin/potassium clavulanate remained febrile. In the 459 culture-negative children more amoxicillin/potassium clavulanate-treated children developed diarrhea and had less improvement in clinical scores after 24 hours than ceftriaxone-treated children. Children 3 to 36 months old with fever greater-than-or-equal-to 39.5-degrees-C and WBC greater-than-or-equal-to 15 x 10(9)/liter and no focus of infection are at high risk (>16%) for having occult bacteremia. Antimicrobial treatment of febrile children with these high risk criteria appears prudent whereas routine treatment of those with low risk criteria does not. Both treatment regimens evaluated are rational and all patients did well. C1 TRIPLER ARMY MED CTR,DEPT EMERGENCY MED,HONOLULU,HI 96859. UNIV ARKANSAS,LITTLE ROCK,AR 72204. WILLIAM BEAUMONT ARMY MED CTR,EL PASO,TX 79920. BROOKE ARMY MED CTR,SAN ANTONIO,TX. PORTSMOUTH USN HOSP,MED CTR,PORTSMOUTH,VA. MADIGAN ARMY MED CTR,TACOMA,WA 98431. KEESLER MED CTR,KEESLER AFB,MS. FAIRFAX HOSP,FAIRFAX,VA. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. USN HOSP,MED CTR,SAN DIEGO,CA 92134. RP BASS, JW (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. RI Steele, Russell/A-6075-2011 NR 30 TC 68 Z9 73 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JUN PY 1993 VL 12 IS 6 BP 466 EP 473 DI 10.1097/00006454-199306000-00003 PG 8 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA LG459 UT WOS:A1993LG45900003 PM 8345978 ER PT J AU THARION, WJ KOBRICK, JL LIEBERMAN, HR FINE, BJ AF THARION, WJ KOBRICK, JL LIEBERMAN, HR FINE, BJ TI EFFECTS OF CAFFEINE AND DIPHENHYDRAMINE ON AUDITORY-EVOKED CORTICAL POTENTIALS SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID HUMAN-PERFORMANCE; MOOD AB Caffeine and diphenhydramine are known to affect cognitive functioning in vigilance tasks. In this study, long-latency auditory evoked potentials (AEPs) obtained during concomitant performance of a visual vigilance task were examined for changes in response to administration of caffeine (200 mg) and diphenhydramine (25 mg). The AEPs were also analyzed for changes over time for up to two hours postdrug administration. Significant increases in N1 and P2 latencies and decreases in amplitude voltage were exhibited over time. The P2-N2 amplitude was significantly lower throughout testing after taking caffeine. A significant increase was seen in the P2-N2 amplitude 40 min. after diphenhydramine ingestion, These changes in amplitude may be the result of the auditory stimulus acting as a diversion to the participants while performing the visual vigilance task. Diphenhydramine was more likely to impair participants' vigilance, resulting in greater attention paid toward the auditory stimulus, whereas caffeine seemed to help participants maintain their focus of attention on the visual vigilance task. RP THARION, WJ (reprint author), USA,ENVIRONM MED RES INST,DIV MIL PERFORMANCE & NEUROSCI,NATICK,MA 01760, USA. NR 22 TC 6 Z9 6 U1 0 U2 0 PU PERCEPTUAL MOTOR SKILLS PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807 SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD JUN PY 1993 VL 76 IS 3 BP 707 EP 715 PN 1 PG 9 WC Psychology, Experimental SC Psychology GA LE389 UT WOS:A1993LE38900001 PM 8321577 ER PT J AU BRYANT, GW AF BRYANT, GW TI INTERDOT TUNNELING AND COULOMB CORRELATION SO PHYSICA B LA English DT Article; Proceedings Paper CT NATO ADVANCED RESEARCH WORKSHOP ON THE PHYSICS OF FEW-ELECTRON NANOSTRUCTURES CY SEP 23-26, 1992 CL NOORDWIJK, NETHERLANDS SP NATO, ADV RES WORKSHOP, NANOSCALE SCI PROGRAMME, DELFT UNIV, ROYAL DUTCH ACAD SCI, FDN PHYSICA, PHILIPS RES LABS, FISONS INSTRUMENTS ID QUANTUM; EXCITONS; STATES; BOXES AB The properties of coupled quantum dot nanostructures depend critically on single-particle interdot tunneling, lateral confinement, and interparticle Coulomb correlations. Calculations of few-electron and electron-hole systems that are confined in coupled, vertical quantum dot structures have been done to obtain a better understanding of the interplay of these effects. Results are presented for symmetric and asymmetric coupled dot structures as a function of the bias applied between the dots and the dot size. The competition between interdot tunneling and Coulomb correlation provides new optical signatures for lateral confinement effects in quantum dots and determines which dot structures will experience Coulomb blockade during tunneling. RP BRYANT, GW (reprint author), USA,RES LAB,MICROPHOTON DEVICES BRANCH,ADELPHI,MD 20783, USA. NR 14 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-4526 J9 PHYSICA B JI Physica B PD JUN PY 1993 VL 189 IS 1-4 BP 34 EP 42 DI 10.1016/0921-4526(93)90144-U PG 9 WC Physics, Condensed Matter SC Physics GA LL338 UT WOS:A1993LL33800006 ER PT J AU MACKIE, DM GLICK, AJ AF MACKIE, DM GLICK, AJ TI SEMICLASSICAL METHOD FOR CALCULATING QUANTUM-LATTICE-FLUCTUATION EFFECTS IN CONDUCTING AND OR OPTICALLY-ACTIVE POLYMERS, WITH RESULTS FOR POLYACETYLENE IN THE SOLITON-ANTISOLITON APPROXIMATION SO PHYSICAL REVIEW B LA English DT Article ID CONJUGATED POLYMERS; TRANS-POLYACETYLENE; GENERATION; ABSORPTION; SPECTRUM; SYSTEMS; MODES AB Deviations from the lowest-energy configuration due to the quantum nature of the lattice-called quantum lattice fluctuations (QLF's)-may significantly affect the properties of conjugated polymers. In this paper, we present a semiclassical method for including QLF effects in calculations of conducting and/or optically active polymer properties. We then apply the method to the first- and third-order absorption intensities of pristine finite chains of trans- and cis-(CH)x containing fluctuation-induced soliton-antisoliton pairs. The first-order results agree with previous calculations, which used different methods. Third-order results indicate that QLF effects are enhanced by asymmetry, and degraded by disorder. They are most important below the three-photon peak, and remain substantial even for nondegenerate ground-state polymers. C1 UNIV MARYLAND,DEPT PHYS,COLL PK,MD 20740. RP MACKIE, DM (reprint author), USA,RES LAB,SI DIRECTORATE,ADELPHI,MD 20783, USA. NR 33 TC 0 Z9 0 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD JUN 1 PY 1993 VL 47 IS 21 BP 14212 EP 14220 DI 10.1103/PhysRevB.47.14212 PG 9 WC Physics, Condensed Matter SC Physics GA LF729 UT WOS:A1993LF72900032 ER PT J AU COKER, KR AF COKER, KR TI THE PALMETTO STATES GOES TO WAR - AN EXHIBITION ON WORLD-WAR-II SO PUBLIC HISTORIAN LA English DT Art Exhibit Review RP COKER, KR (reprint author), USA,FT GORDON,GA 30905, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SUM PY 1993 VL 15 IS 3 BP 100 EP 101 PG 2 WC History SC History GA LQ704 UT WOS:A1993LQ70400028 ER PT J AU SYLLAIOS, AJ LITTLER, CL SONG, XN LOPES, VC CHRISTENSEN, CR GRISHAM, JA CLARKE, FW AF SYLLAIOS, AJ LITTLER, CL SONG, XN LOPES, VC CHRISTENSEN, CR GRISHAM, JA CLARKE, FW TI FARADAY-ROTATION ANALYSIS OF HGCDTE SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT INTERNATIONAL WORKSHOP ON MERCURY CADMIUM TELLURIDE CHARACTERIZATION CY OCT 15-16, 1992 CL DANVERS, MA SP NIST ID INSB AB Faraday rotation was measured in liquid-phase epitaxial (LPE) Hg1-xCdxTe (x almost-equal-to 0.22) at CO2 laser photon energies over the temperature range of 77 K to 300 K for magnetic fields up to 16 kG. We find that the Faraday rotation is composed of free-carrier, interband and spin-induced contributions. At 77 K, the interband and spin contributions dominate, resulting in large observed Faraday rotation, i.e. of the order of 10(2) deg cm-1 kG-1. All three contributions are needed to interpret the temperature and magnetic field dependence of the Faraday rotation in our samples. Resonant behaviour observed in the rotation angle is successfully described by impurity-to-band magneto-optical absorption. We conclude that Faraday rotation could serve as a viable technique for the non-contact measurement of carrier concentration in Hg1-xCdxTe. C1 UNIV N TEXAS,DEPT PHYS,DENTON,TX 76203. USA,MISSILE COMMAND,HUNTSVILLE,AL. RP SYLLAIOS, AJ (reprint author), TEXAS INSTRUMENTS INC,POB 655936,DALLAS,TX 75265, USA. NR 19 TC 4 Z9 4 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD JUN PY 1993 VL 8 IS 6 SU S BP 953 EP 957 DI 10.1088/0268-1242/8/6S/017 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA LL644 UT WOS:A1993LL64400018 ER PT J AU BURKE, DS AF BURKE, DS TI OF POSTULATES AND PECCADILLOES - ROBERT KOCH AND VACCINE (TUBERCULIN) THERAPY FOR TUBERCULOSIS SO VACCINE LA English DT Review DE KOCH; VACCINE THERAPY; TUBERCULOSIS; HIV AB In August 1890, Robert Koch dramatically announced that he had discovered a cure for tuberculosis, and the world rejoiced. The miracle substance was subsequently revealed to be tuberculin, inoculated as a 'vaccine therapy'. However, within a matter of months his claims were disputed and debunked, and his reputation was grievously damaged. The nationalistic pressures, professional jealousies and pecuniary interests that drove Koch's premature announcement are reviewed here and discussed in a context relevant to the development of therapeutic vaccines for human immunodeficiency virus infections. RP BURKE, DS (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,13 TAFT COURT,SUITE 101,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 50 TC 17 Z9 17 U1 0 U2 3 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD JUN PY 1993 VL 11 IS 8 BP 795 EP 804 DI 10.1016/0264-410X(93)90354-Z PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA LH325 UT WOS:A1993LH32500001 PM 8356842 ER PT J AU SHAFFERMAN, A LEWIS, MG MCCUTCHAN, FE BENVENISTE, RE JAHRLING, PB BURKE, DS EDDY, GA AF SHAFFERMAN, A LEWIS, MG MCCUTCHAN, FE BENVENISTE, RE JAHRLING, PB BURKE, DS EDDY, GA TI PREVENTION OF TRANSMISSION OF SIMIAN IMMUNODEFICIENCY VIRUS FROM VACCINATED MACAQUES THAT DEVELOPED TRANSIENT VIRUS-INFECTION FOLLOWING CHALLENGE SO VACCINE LA English DT Article DE SIMIAN IMMUNODEFICIENCY VIRUS; TRANSMISSION; MACAQUES; ENVELOPE PEPTIDE VACCINE ID CYNOMOLGUS MONKEYS; RHESUS MACAQUES; HTLV-III; PROTECTION; RETROVIRUS; AIDS; DISEASE; HIV-2; IMMUNIZATION; LENTIVIRUS AB Macaque immunization with a mixture of four SIV peptides from conserved hydrophilic envelope regions has been shown to prevent virus persistence following challenge with SIV(mne/E11s). Data shown here demonstrate that lymph node cells from all vaccinated monkeys and peripheral blood lymphocytes from one of the vaccinees were positive in a SIV-pol 'nested' polymerase chain reaction (PCR) amplification analysis. However, by 37 months after infection, all immunized monkeys were healthy while two of three controls had died and the remaining animal was virus culture-positive and had declining CD4+ lymphocytes. Viable lymph node cells and peripheral lymphoid cells in blood were transferred from the three immunized macaques to individual susceptible macaques. As a control for the transfer, one of the vaccine experiment controls that was actively producing virus in its peripheral blood was used. None of the recipients of cells from the vaccinated macaques seroconverted and all were virus coculture- and PCR-negative 25 weeks post-transfer (p.t.). The recipient of cells from the control infected macaque became positive in these tests by 2- 3 weeks p. t. These results suggest thal, while peptide-vaccinated macaques permitted some level of SIV replication following challenge, the vaccine prevented disease progression and virus transmission. C1 HENRY M JACKSON FDN,RES LAB,ROCKVILLE,MD 20852. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20852. NCI,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP SHAFFERMAN, A (reprint author), ISRAEL INST BIOL RES,DEPT BIOCHEM,POB 19,IL-70450 NESS ZIONA,ISRAEL. OI /0000-0002-5704-8094 NR 38 TC 9 Z9 9 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD JUN PY 1993 VL 11 IS 8 BP 848 EP 852 DI 10.1016/0264-410X(93)90360-A PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA LH325 UT WOS:A1993LH32500007 PM 8356845 ER PT J AU GOLDEN, JR AF GOLDEN, JR TI ECONOMICS AND NATIONAL STRATEGY - CONVERGENCE, GLOBAL NETWORKS, AND COOPERATIVE COMPETITION SO WASHINGTON QUARTERLY LA English DT Article ID LEADERSHIP RP GOLDEN, JR (reprint author), US MIL ACAD,DEPT SOCIAL SCI,W POINT,NY 10996, USA. NR 43 TC 2 Z9 2 U1 0 U2 0 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD ST JOURNALS DEPT, CAMBRIDGE, MA 02142 SN 0163-660X J9 WASH QUART JI Wash. Q. PD SUM PY 1993 VL 16 IS 3 BP 91 EP 113 PG 23 WC International Relations; Law SC International Relations; Government & Law GA LF576 UT WOS:A1993LF57600006 ER PT J AU KIM, BJ GEE, CS AF KIM, BJ GEE, CS TI HAZARDOUS-WASTE TREATMENT TECHNOLOGIES SO WATER ENVIRONMENT RESEARCH LA English DT Review ID VOLATILE ORGANIC-COMPOUNDS; SOLIDIFICATION STABILIZATION; CONTAMINATED SOILS; AROMATIC-HYDROCARBONS; THERMAL-DECOMPOSITION; BIODEGRADATION RATES; CHEMICAL OXIDATION; AQUEOUS-SOLUTIONS; ACTIVATED CARBON; TOXIC ORGANICS C1 KOREA CONSTRUCT TECHNOL RES LAB, SEOUL, SOUTH KOREA. RP KIM, BJ (reprint author), USA, CONSTRUCT ENGN RES LABS, POB 9005, CHAMPAIGN, IL 61826 USA. NR 218 TC 2 Z9 2 U1 1 U2 1 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA SN 1061-4303 J9 WATER ENVIRON RES JI Water Environ. Res. PD JUN PY 1993 VL 65 IS 4 BP 430 EP 441 PG 12 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA LM722 UT WOS:A1993LM72200027 ER PT J AU LEE, RR PASSNER, JE AF LEE, RR PASSNER, JE TI THE DEVELOPMENT AND VERIFICATION OF TIPS - AN EXPERT-SYSTEM TO FORECAST THUNDERSTORM OCCURRENCE SO WEATHER AND FORECASTING LA English DT Article AB A rule-based expert system has been developed to assist military weather forecasters in the prediction of thunderstorms. The knowledge base used by the Thunderstorm Intelligence Prediction System (TIPS) was built by using meteorological principles associated with convective activity. The goal of TIPS is to provide a gen system that can be used at any geographical location. TIPS was evaluated during the spring and summer months of 1990 for several locations across the United States. Thunderstorm forecasts were derived using 1200 UTC, atmospheric sounding data, and a single forecaster input value. Verification results show that TIPS can assist the weather forecaster in predicting thunderstorm occurrence. RP LEE, RR (reprint author), USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 0 TC 23 Z9 23 U1 0 U2 4 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0882-8156 J9 WEATHER FORECAST JI Weather Forecast. PD JUN PY 1993 VL 8 IS 2 BP 271 EP 280 DI 10.1175/1520-0434(1993)008<0271:TDAVOT>2.0.CO;2 PG 10 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA LL627 UT WOS:A1993LL62700011 ER PT J AU SPARIOSU, K STULTZ, RD BIRNBAUM, M ALLIK, TH HUTCHINSON, JA AF SPARIOSU, K STULTZ, RD BIRNBAUM, M ALLIK, TH HUTCHINSON, JA TI ERCA5(PO4)3F SATURABLE-ABSORBER Q-SWITCH FOR THE ER-GLASS LASER AT 1.53 MU-M SO APPLIED PHYSICS LETTERS LA English DT Article AB Passive Q switching of an Er:phosphate glass laser using Er:Ca5(PO4)3F (Er:FAP) as a saturable absorber intracavity (IC) load is described for the first time. Q-switched output was obtained consisting of a 6-mJ single pulse of 83 ns full width at half maximum, with a 20% efficiency relative to the corresponding free-running output in the absence of the IC Er:FAP load. C1 SCI APPLICAT INT CORP,MCLEAN,VA 22102. USA,CECOM,NIGHT VIS & ELECTR SENSORS DIRECTORATE,FT BELVOIR,VA 22060. RP SPARIOSU, K (reprint author), UNIV SO CALIF,CTR LASER STUDIES,DRB B17,UNIT PK,LOS ANGELES,CA 90089, USA. NR 9 TC 45 Z9 45 U1 0 U2 5 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 31 PY 1993 VL 62 IS 22 BP 2763 EP 2765 DI 10.1063/1.109253 PG 3 WC Physics, Applied SC Physics GA LE353 UT WOS:A1993LE35300007 ER PT J AU ZAVADA, JM CASEY, HC CHEN, CH LONI, A AF ZAVADA, JM CASEY, HC CHEN, CH LONI, A TI CORRELATION OF REFRACTIVE-INDEX PROFILES WITH SUBSTITUTIONAL HYDROGEN CONCENTRATIONS IN ANNEALED PROTON-EXCHANGED LINBO3 WAVE-GUIDES SO APPLIED PHYSICS LETTERS LA English DT Article ID WAVE-GUIDES AB We have studied the behavior of the extraordinary refractive index in a set of annealed z-cut proton-exchanged lithium niobate (LiNbO3) substrates by means of optical prism-coupling measurements and numerical simulations. Values of the index as a function of depth have been determined and fitted with a single Gaussian diffusion expression. At 400-degrees-C, the effective index diffusivity D(n) of 4.6 x 10(-12) cm-2/s is nearly identical to the diffusivity of substitutional H in these samples. Furthermore, we find a linear relationship between the increase in the extraordinary refractive index and the substitutional H concentration. At a wavelength of 0.6238 mum, the coefficient for this relationship is approximately 1.5 X 10(-23) (H cm-3)-1. C1 DUKE UNIV,DEPT ELECT ENGN,DURHAM,NC 27708. DEF RES AGCY,GREAT MALVERN WR14 3PS,WORCS,ENGLAND. RP ZAVADA, JM (reprint author), USA,RES OFF,RES TRIANGLE PK,NC 27709, USA. NR 11 TC 19 Z9 19 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 31 PY 1993 VL 62 IS 22 BP 2769 EP 2771 DI 10.1063/1.109255 PG 3 WC Physics, Applied SC Physics GA LE353 UT WOS:A1993LE35300009 ER PT J AU HUMI, M AF HUMI, M TI 3-DIMENSIONAL VORTEX METHOD FOR PARACHUTES SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS LA English DT Article DE PARACHUTES; VORTEX METHODS; CFD; SPECTRAL ANALYSIS ID FLOWS AB We describe the implementation of a new 3D vortex algorithm for the computation of the drag and flow field around parachutes. Among its novel features, the algorithm couples large eddy simulation methodology with the vortex method, away from the wall region. Furthermore, boundary conditions for a wall (no-slip) and compliant boundaries were implemented. The results of several simulations using this algorithm are analysed and discussed. The spectral contents of the vortex method are also considered. C1 USA,NATICK RD&E CTR,NATICK,MA 01760. RP HUMI, M (reprint author), WORCESTER POLYTECH INST,DEPT MATH SCI,100 INST RD,WORCESTER,MA 01609, USA. NR 17 TC 1 Z9 1 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0271-2091 J9 INT J NUMER METH FL JI Int. J. Numer. Methods Fluids PD MAY 30 PY 1993 VL 16 IS 10 BP 879 EP 889 DI 10.1002/fld.1650161003 PG 11 WC Computer Science, Interdisciplinary Applications; Mathematics, Interdisciplinary Applications; Mechanics; Physics, Fluids & Plasmas SC Computer Science; Mathematics; Mechanics; Physics GA LC011 UT WOS:A1993LC01100002 ER PT J AU RAY, P BERMAN, JD MIDDLETON, W BRENDLE, J AF RAY, P BERMAN, JD MIDDLETON, W BRENDLE, J TI BOTULINUM TOXIN INHIBITS ARACHIDONIC-ACID RELEASE ASSOCIATED WITH ACETYLCHOLINE-RELEASE FROM PC12 CELLS SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID PROTEIN-KINASE-C; ADRENAL CHROMAFFIN CELLS; CATECHOLAMINE SECRETION; DIGLYCERIDE LIPASE; BINDING-PROTEIN; RAT; ACTIVATION; MECHANISM; PLATELET; PHOSPHOLIPASE-A2 AB The molecular mechanisms of depolarization-induced calcium-dependent acetylcholine (ACh) release and its inhibition by botulinum neurotoxin type A (BoTx) are not clear. We studied these mechanisms in an in vitro cholinergic neuronal pheochromocytoma PC12 cell line model. Cultured monolayer PC12 cells were differentiated by treatment with 50 ng/ml nerve growth factor (NGF) for 4 days to enhance cellular ACh synthesis and release. Stimulation of these cells with high K+ (80 mM) in the perfusion medium caused a marked increase (three to four times) in [H-3]ACh release in a Ca2+-dependent manner. K+-stimulated [H-3]ACh release was totally inhibited by pretreatment of cells with BoTx (2 nM) for 2 h. High K+ also stimulated the release of arachidonic acid ([H-3]AA) from the cell membrane, which was inhibited by BoTx (2 nM). Addition of phospholipase A2 (PLA2) inhibitors (quinacrine, 4-bromophenacyl bromide, manoalide) to the perfusion medium inhibited K+-stimulated [H-3]ACh and [H-3]AA release in a dose-dependent manner. Inclusion of exogenous AA, the PLA2 activator melittin, or PLA2 itself prevented the effect of BoTx. These results demonstrate that in NGF-differentiated PC12 cells, AA release is associated with ACh release, BoTx inhibits both processes, and increased AA can protect against BoTx. C1 WALTER REED ARMY INST RES, DEPT BIOL, DIV EXPTL THERAPEUT, WASHINGTON, DC 20067 USA. NR 51 TC 55 Z9 55 U1 1 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAY 25 PY 1993 VL 268 IS 15 BP 11057 EP 11064 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA LD466 UT WOS:A1993LD46600052 PM 8496167 ER PT J AU ZHANG, XC JIN, Y AF ZHANG, XC JIN, Y TI INFLUENCE OF ELECTRIC AND MAGNETIC-FIELDS ON THZ RADIATION SO APPLIED PHYSICS LETTERS LA English DT Article AB We report measurement of the influence of electric and magnetic fields on optically induced THz electromagnetic radiation from semiconductors at normal incidence. The measurements show that electric and magnetic fields strongly influence the amplitude and phase of transient carrier-generated THz radiation, but do not affect THz optical rectification generated by the bulk second order nonlinear susceptibility, for static electric fields up to 10(4) V/CM. C1 USA,RES LAB,CTR PULSE POWER,FT MONMOUTH,NJ 07703. RP ZHANG, XC (reprint author), RENSSELAER POLYTECH INST,DEPT PHYS,TROY,NY 12180, USA. RI Zhang, Xi-Cheng/G-1306-2016 OI Zhang, Xi-Cheng/0000-0003-3721-1357 NR 9 TC 15 Z9 16 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 17 PY 1993 VL 62 IS 20 BP 2477 EP 2479 DI 10.1063/1.109324 PG 3 WC Physics, Applied SC Physics GA LB885 UT WOS:A1993LB88500007 ER PT J AU HAN, WY CALDERON, L LU, Y SCHAUER, SN MOERKIRK, RP LEE, HS FLEMISH, JR JONES, KA YANG, LW AF HAN, WY CALDERON, L LU, Y SCHAUER, SN MOERKIRK, RP LEE, HS FLEMISH, JR JONES, KA YANG, LW TI EFFECTS OF ANNEALING CONDITIONS ON HEAVILY CARBON-DOPED INGAAS SO APPLIED PHYSICS LETTERS LA English DT Article ID MOLECULAR-BEAM EPITAXY; VAPOR-PHASE EPITAXY; P-TYPE GAAS; MOMBE AB Two heavily carbon doped InGaAs samples (2.20 X 10(19) and 1.92 X 10(19) cm-3) with low In mol fractions (1% and 8%) were annealed with or without silicon nitride caps in H-2 containing 0.3% AsH3 over the temperature range 5000-800-degrees-C. Hall effect, secondary ion mass spectroscopy, double crystal x-ray diffraction, and integrated photoluminescence measurements showed that H outdiffuses over the annealing temperature range when the films were capped with silicon nitride. However, there was almost no net H outdiffusion for uncapped samples annealed in the same ambient and temperature range. Recombination centers formed during high temperature anneals in samples with less In (1%), but did not appear to form as readily in the one with more In (8%). C1 GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. USA,ELECTR TECHNOL & DEVICE LAB,FT MONMOUTH,NJ 07703. FORD MICROELECTR INC,COLORADO SPRINGS,CO 80921. RP HAN, WY (reprint author), RUTGERS UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855, USA. NR 17 TC 0 Z9 0 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 17 PY 1993 VL 62 IS 20 BP 2578 EP 2580 DI 10.1063/1.109302 PG 3 WC Physics, Applied SC Physics GA LB885 UT WOS:A1993LB88500041 ER PT J AU HAYES, S GREBOGI, C OTT, E AF HAYES, S GREBOGI, C OTT, E TI COMMUNICATING WITH CHAOS SO PHYSICAL REVIEW LETTERS LA English DT Article ID STRANGE ATTRACTORS; NOISE-REDUCTION; SYSTEMS AB The use of chaos to transmit information is described. Chaotic dynamical systems, such as electrical oscillators with very simple structures, naturally produce complex wave forms. We show that the symbolic dynamics of a chaotic oscillator can be made to follow a desired symbol sequence by using small perturbations, thus allowing us to encode a message in the wave form. We illustrate this using a simple numerical electrical oscillator model. C1 UNIV MARYLAND,DEPT PHYS & ASTRON,COLL PK,MD 20742. UNIV MARYLAND,PLASMA RES LAB,COLL PK,MD 20742. UNIV MARYLAND,INST PHYS SCI & TECHNOL,COLL PK,MD 20742. UNIV MARYLAND,DEPT MATH,COLL PK,MD 20742. UNIV MARYLAND,DEPT ELECT ENGN,COLL PK,MD 20742. RP HAYES, S (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. RI O, E/F-1630-2015 NR 17 TC 407 Z9 420 U1 0 U2 12 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAY 17 PY 1993 VL 70 IS 20 BP 3031 EP 3034 DI 10.1103/PhysRevLett.70.3031 PG 4 WC Physics, Multidisciplinary SC Physics GA LB784 UT WOS:A1993LB78400015 ER PT J AU JOHNSON, JB SOLIE, DJ BROWN, JA GAFFNEY, ES AF JOHNSON, JB SOLIE, DJ BROWN, JA GAFFNEY, ES TI SHOCK RESPONSE OF SNOW SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB We conducted gas-gun impact experiments on snow, with initial densities of 100-520 kg m-3 and at temperatures from -2 to -23-degrees-C and stress levels of 2-40 MPa. Carbon stress gauges were embedded in the snow to measure shock stress histories and arrival times. The unsteady and complex nature of the shock stresses necessitated the use of finite element and reverberation analysis techniques to determine the shock pressure-density (P-rho) relationships for snow. Experimental results indicate that variations in initial snow density are reflected in differences in the P-rho deformation path. The pressure needed to compact snow to a specific final density increases with lower initial density. Snow deformation was not affected by initial temperature, but was found to be strain rate dependent. Estimated release moduli increased nonlinearly from 50 MPa at a peak compression pressure of about 15 up to 2700 MPa at a peak pressure of about 40 MPa. Calculated stress histories and shock arrival times agreed with measured values within 20%. C1 LOS ALAMOS NATL LAB,LOS ALAMOS,NM 87545. KTECH CORP INC,ALBUQUERQUE,NM 87110. RP JOHNSON, JB (reprint author), USA,COLD REG RES & ENGN LAB,BLDG 4070,FT WAINWRIGHT,AK 99703, USA. NR 21 TC 8 Z9 8 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 15 PY 1993 VL 73 IS 10 BP 4852 EP 4861 DI 10.1063/1.353801 PN 1 PG 10 WC Physics, Applied SC Physics GA LD851 UT WOS:A1993LD85100019 ER PT J AU JOW, TR CYGAN, PJ AF JOW, TR CYGAN, PJ TI DIELECTRIC-BREAKDOWN OF POLYVINYLIDENE FLUORIDE AND ITS COMPARISONS WITH OTHER POLYMERS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID STRETCHED POLY(VINYLIDENE FLUORIDE); HEAT-CAPACITY; PIEZOELECTRICITY; PYROELECTRICITY; HYSTERESIS; FILMS AB Using ac and dc methods, we have investigated the dielectric strengths of polyvinylidene fluoride (PVDF)-a ferroelectric/piezoelectric polymer, and some nonferroelectric polymers. The ac to dc ratio of breakdown strengths for PVDF is significantly lower than for other polymers. This observation is discussed in terms of the specific dielectric properties of PVDF, namely, its ferroelectricity and piezoelectricity. RP JOW, TR (reprint author), USA,ELECTR & POWER SOURCES DIRECTORATE,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 29 TC 22 Z9 22 U1 2 U2 13 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 15 PY 1993 VL 73 IS 10 BP 5147 EP 5151 DI 10.1063/1.353789 PN 1 PG 5 WC Physics, Applied SC Physics GA LD851 UT WOS:A1993LD85100060 ER PT J AU CHOI, KK AF CHOI, KK TI DETECTION WAVELENGTH OF QUANTUM-WELL INFRARED PHOTODETECTORS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID DARK CURRENT; SUPERLATTICE; ABSORPTION; STATES; BAND AB Long wavelength infrared detection using intersubband transitions has been progressing rapidly in recent years. One advantage of the quantum-well infrared photodetectors is the wavelength tunability as a function of their structural parameters. In this work, we have performed a systematic calculation on the detection wavelength, the absorption linewidth, and the oscillator strength of a typical GaAs/AlxGa1-xAs multiple-quantum-well photodetector, with aluminum molar ratio in the barriers ranging from 0.14 to 0.42 and the quantum-well width ranging from 20 to 70 angstrom. We found that within these material parameters, the detection wavelength can be varied from 5 to over 25 mum. In addition, we also discuss the photoconductive gain of the detectors with respect to the energies of the final state of the optical transition and the satellite valleys of the detector material. RP CHOI, KK (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 29 TC 36 Z9 40 U1 1 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 15 PY 1993 VL 73 IS 10 BP 5230 EP 5236 DI 10.1063/1.353751 PN 1 PG 7 WC Physics, Applied SC Physics GA LD851 UT WOS:A1993LD85100075 ER PT J AU LEUPOLD, HA TILAK, AS POTENZIANI, E AF LEUPOLD, HA TILAK, AS POTENZIANI, E TI MULTI-TESLA PERMANENT-MAGNET FIELD SOURCES SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 37TH ANNUAL CONF ON MAGNETISM AND MAGNETIC MATERIALS CY DEC 01-04, 1992 CL HOUSTON, TX AB Both cylindrical (''magic ring'') and spherical (''magic sphere'') dipolar Permanent magnet field sources are capable of providing arbitrarily high fields in their interior cavities. However, since the obtainable field increases only logarithmically with the structural radius, fields above about 2.5 T necessitate excessively massive and costly structures if working volumes of more than a few cm3 are desired. The present work shows how for some cavity shapes the structures can be modified to produce fields up to 4.0 T with only about one fifth the mass and bulk of the conventional structures. Possible applications which would be impractical with the unmodified field sources are cited. RP LEUPOLD, HA (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,SLCET-ET-H,FT MONMOUTH,NJ 07703, USA. NR 5 TC 7 Z9 10 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 15 PY 1993 VL 73 IS 10 BP 6861 EP 6863 DI 10.1063/1.352463 PN 2B PG 3 WC Physics, Applied SC Physics GA LD865 UT WOS:A1993LD86500267 ER PT J AU CHEN, YY AF CHEN, YY TI BERNOULLI TRIALS - FROM A FUZZY MEASURE POINT-OF-VIEW SO JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS LA English DT Article RP CHEN, YY (reprint author), USA,CONCEPT ANAL AGCY,BETHESDA,MD 20814, USA. NR 12 TC 2 Z9 2 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0022-247X J9 J MATH ANAL APPL JI J. Math. Anal. Appl. PD MAY 15 PY 1993 VL 175 IS 2 BP 392 EP 404 DI 10.1006/jmaa.1993.1178 PG 13 WC Mathematics, Applied; Mathematics SC Mathematics GA LF124 UT WOS:A1993LF12400006 ER PT J AU ESSIEN, M ARMSTRONG, RL GILLESPIE, JB AF ESSIEN, M ARMSTRONG, RL GILLESPIE, JB TI LASING EMISSION FROM AN EVAPORATING LAYERED MICRODROPLET SO OPTICS LETTERS LA English DT Article ID LASER-EMISSION; RESONANCES; SCATTERING; DROPLETS AB We report the first observations, to our knowledge, of lasing emission from a single, evaporating, layered, micrometer-sized droplet. The droplet consists of an approximately 7.9-mum-radius glass core covered by a liquid shell of an initial 3 x 10(-4) M Rhodamine 6G dye-doped glycerin/water solution. After pumping by a doubled (532 nm) Nd:YAG pulsed laser, droplet lasing occurs over a range of shell thicknesses from approximately 14.5 to approximately 0.4 mum. At the smallest shell thickness, a dramatic increase in both the number and intensity of the lasing peaks occurs, in addition to a large (>40-nm) blue shift in the spectral bandwidth of lasing emission. A discussion of possible enhancement mechanisms responsible for these novel findings is given. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP ESSIEN, M (reprint author), NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003, USA. NR 13 TC 11 Z9 11 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD MAY 15 PY 1993 VL 18 IS 10 BP 762 EP 764 DI 10.1364/OL.18.000762 PG 3 WC Optics SC Optics GA LA947 UT WOS:A1993LA94700002 PM 19802264 ER PT J AU SHEN, H WRABACK, M PAMULAPATI, J NEWMAN, PG DUTTA, M LU, Y KUO, HC AF SHEN, H WRABACK, M PAMULAPATI, J NEWMAN, PG DUTTA, M LU, Y KUO, HC TI OPTICAL ANISOTROPY IN GAAS/ALXGA1-XAS MULTIPLE-QUANTUM WELLS UNDER THERMALLY-INDUCED UNIAXIAL STRAIN SO PHYSICAL REVIEW B LA English DT Note ID STRESS; FILMS AB The effect of thermally induced in-plane uniaxial strain on the optical properties of a GaAs/AlxGa1-xAs multiple quantum well (MQW) has been studied in detail. The strain was produced by bonding the MQW thin films to LiTaO3, a transparent substrate which possesses a direction-dependent thermal expansion coefficient. At temperatures different from the bonding temperature we have observed an anisotropy in the optical properties of the MQW due to the strain-induced lowering of its in-plane fourfold rotation symmetry. The anisotropic absorption and birefringence for light incident normal to such a MQW structure have been determined and compared to a theory involving the mixing of the valence subbands. C1 GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. RUTGERS UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. RP SHEN, H (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,AMSRL-EP-EF,FT MONMOUTH,NJ 07703, USA. NR 14 TC 37 Z9 37 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD MAY 15 PY 1993 VL 47 IS 20 BP 13933 EP 13936 DI 10.1103/PhysRevB.47.13933 PG 4 WC Physics, Condensed Matter SC Physics GA LF069 UT WOS:A1993LF06900118 ER PT J AU MAGILL, AJ GROGL, M GASSER, RA SUN, W OSTER, CN AF MAGILL, AJ GROGL, M GASSER, RA SUN, W OSTER, CN TI VISCERAL INFECTION CAUSED BY LEISHMANIA-TROPICA IN VETERANS OF OPERATION DESERT STORM SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID RENAL-TRANSPLANT RECIPIENT; FATAL LEISHMANIASIS; MEDITERRANEAN LEISHMANIASIS; OPPORTUNISTIC INFECTION; SODIUM STIBOGLUCONATE; DISEASE; CULTIVATION; DONOVANI; INVITRO; THERAPY AB Background. visceral leishmaniasis, usually caused by Leishmania donovani, has rarely been reported from eastern Saudi Arabia, so it was not expected to affect the soldiers of Operation Desert Storm. Methods. We evaluated eight soldiers with visceral leishmanial infection, examining their serum with an immunofluorescent-antibody assay, examining their marrow or biopsy tissue for amastigotes with an indirect immunofluorescent-monoclonal-antibody assay, and culturing the parasites. Cultured promastigotes were isolated and characterized by isoenzyme analysis. Results. None of the eight soldiers had classic signs or symptoms of visceral leishmaniasis (kala-azar). Seven soldiers had unexplained fever, chronic fatigue, malaise, cough, intermittent diarrhea, or abdominal pain that began up to seven months after they returned to the United States; one had no symptoms. Five had adenopathy or mild, transient hepatosplenomegaly. None had cutaneous manifestations. Diagnoses were made by bone marrow aspiration (seven patients) or lymph-node biopsy (one patient). Six isolates have been identified as L. tropica, which usually causes only cutaneous disease. Of the six patients treated with sodium stibogluconate, five improved and one remained symptomatic. Conclusions. L. tropica can produce visceral infection that can cause unexplained systemic illness in persons returning from areas where this organism is endemic. C1 WALTER REED ARMY MED CTR,INFECT DIS SECT,WASHINGTON,DC 20307. RP MAGILL, AJ (reprint author), WALTER REED ARMY INST RES,DEPT IMMUNOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 48 TC 247 Z9 257 U1 0 U2 4 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAY 13 PY 1993 VL 328 IS 19 BP 1383 EP 1387 DI 10.1056/NEJM199305133281904 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA LB495 UT WOS:A1993LB49500004 PM 8292114 ER PT J AU BEHRMANN, GP BOWEN, JP AF BEHRMANN, GP BOWEN, JP TI INFLUENCE OF TEMPERATURE ON DIFFRACTIVE LENS PERFORMANCE SO APPLIED OPTICS LA English DT Article DE DIFFRACTIVE OPTICS; THERMAL EFFECTS; ATHERMALIZATION AB The thermal properties of lenses play an important role in the performance of optical systems. We discuss the effects of uniform temperature changes and thermal gradients on diffractive lens performance. Comparisons are made between the thermal sensitivity of refractive and diffractive lenses. Useful design equations are presented that describe focal length, phase coefficients, and diffraction efficiency as functions of temperature. We present important thermal data for a number of lens materials. The optothermal expansion coefficient is used to design athermalized lenses that combine refractive and diffractive surfaces. C1 ROCHESTER PHOTON CORP, ROCHESTER, NY 14623 USA. RP BEHRMANN, GP (reprint author), USA, RES LAB, 2800 POWDER MILL RD, ADELPHI, MD 20783 USA. NR 16 TC 27 Z9 43 U1 2 U2 13 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAY 10 PY 1993 VL 32 IS 14 BP 2483 EP 2489 PG 7 WC Optics SC Optics GA LA800 UT WOS:A1993LA80000002 PM 20820407 ER PT J AU SIDICK, E KNOESEN, A MAIT, JN AF SIDICK, E KNOESEN, A MAIT, JN TI DESIGN AND RIGOROUS ANALYSIS OF HIGH-EFFICIENCY ARRAY GENERATORS SO APPLIED OPTICS LA English DT Article DE SURFACE-RELIEF GRATING; ARRAY GENERATOR; KINOFORM; DIFFRACTION THEORY ID SURFACE-RELIEF GRATINGS; MULTIPLE BEAMS; BINARY-PHASE; DIFFRACTION AB One-dimensional array generators with seven to fifteen spots are designed by the method of virtual sources in combination with simulated-annealing optimization. Continuous surface-relief grating array generators and their discretized versions are analyzed with rigorous diffraction theory, and the results are compared with those obtained from Fourier-optics theory. The array-generator designs have high diffraction efficiency and good uniformity. C1 USA, RES LAB, ADELPHI, MD 20783 USA. RP SIDICK, E (reprint author), UNIV CALIF DAVIS, DEPT ELECT ENGN & COMP SCI, DAVIS, CA 95616 USA. NR 13 TC 26 Z9 26 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAY 10 PY 1993 VL 32 IS 14 BP 2599 EP 2605 PG 7 WC Optics SC Optics GA LA800 UT WOS:A1993LA80000016 PM 20820421 ER PT J AU HOGE, CW SHLIM, DR RAJAH, R TRIPLETT, J SHEAR, M RABOLD, JG ECHEVERRIA, P AF HOGE, CW SHLIM, DR RAJAH, R TRIPLETT, J SHEAR, M RABOLD, JG ECHEVERRIA, P TI EPIDEMIOLOGY OF DIARRHEAL ILLNESS ASSOCIATED WITH COCCIDIAN-LIKE ORGANISM AMONG TRAVELERS AND FOREIGN RESIDENTS IN NEPAL SO LANCET LA English DT Article ID CAMPYLOBACTER-JEJUNI; TRAVELERS; CHILDREN AB A newly described organism called CLB (coccidian-like or cyanobacterium-like body) has been identified in cases of prolonged diarrhoea. To confirm an association of CLB with disease and identify risk factors for transmission, we conducted a case-control study of travellers and foreign residents at two outpatient clinics in Kathmandu, Nepal. Patients without diarrhoea were matched to CLB cases by clinic and date of visit. For comparison, patients with other causes of diarrhoea were also studied. Stools were examined for enteric pathogens with standard microbiological and molecular genetic techniques. CLB was identified in 108 (11%) of 964 individuals with gastrointestinal symptoms compared with only 1 (1%) of 96 symptom-free controls (p=0.003). 7% of residents in the US Embassy community acquired the infection. The diarrhoeal illness associated with CLB lasted a median of 7 weeks (interquartile range 4-9) compared with 9 days (4-19) for individuals with other causes of diarrhoea (p<0.0001). The prevalence of other enteric pathogens was no higher among CLB cases than among symptom-free controls. Patients with CLB infection were more likely than controls to report consumption of untreated water (odds ratio 3.98; 95% Cl 1.29-13.14); organisms of the same appearance were identified in an epidemiologically implicated water sample. The significant association of CLB with prolonged diarrhoea, and the low rate of other enteropathogens in CLB cases, strongly supports the hypothesis that CLB is a new pathogen. Epidemiological and environmental data suggest that the organism is waterborne. C1 US EMBASSY,MED CLIN,KATMANDU,NEPAL. CANADIAN INT WATER & ENERGY CONSULTANTS CLIN,KATMANDU,NEPAL. RP HOGE, CW (reprint author), USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,DEPT BACTERIOL IMMUNOL & MOLEC GENET,BANGKOK 10400,THAILAND. NR 17 TC 133 Z9 138 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD MAY 8 PY 1993 VL 341 IS 8854 BP 1175 EP 1179 DI 10.1016/0140-6736(93)91002-4 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA LB017 UT WOS:A1993LB01700004 PM 8098077 ER PT J AU CHABALOWSKI, CF GARMER, DR JENSEN, JO KRAUSS, M AF CHABALOWSKI, CF GARMER, DR JENSEN, JO KRAUSS, M TI REACTION FIELD CALCULATION OF THE SPECTRAL SHIFTS OF INDOLE SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID FLUORESCENCE EXCITATION-SPECTRA; EXCITED-STATE; TRYPTOPHAN; SPECTROSCOPY; DERIVATIVES; BANDS AB The excitation energy of indole has been investigated at geometries relevant to both the absorption and emission spectra using first-order configuration interaction (FOCI) methods. The calculation focused on the shift in the relative energy between the two excited states, L(B) and L(A), and the excitation energies with geometry. A reaction field calculation also examined the shift in excitation energies when the molecule is dissolved in water. The excited states are found to be separated in vacuo by about 4500 cm-1 at both the ground state and an approximation to the equilibrium L(B) geometry, M, and by 2500 cm -1 at the optimized geometry of both the first triplet excited state, T, and the first excited singlet state represented by a singles only configuration interaction (S1). In water, the excited states are essentially degenerate and mixed at the ground-state geometry. However, at the excited state geometries, M and T, the L(A) state is shifted lower in energy than the L(B) state due to the large LA excited-state reaction field. At the SI geometry, the electronic behavior of the two excited states is different from that at the other geometries. An approximation to the L(A) state is now the lower state both in vacuo and in the presence of the reaction field. There is a large calculated solvent fluorescent red shift in water at any geometry as well as a substantial Franck-Condon shift due to the steeper energy surface in the ground state compared to the excited states. The calculated energy shifts, dipole moments, and relative transition dipoles are in qualitative accord with experiment. However, the calculated fluorescent reaction dipoles are substantially larger than estimated in earlier studies. C1 NATL INST STAND & TECHNOL,CTR ADV RES BIOTECHNOL,GAITHERSBURG,MD 20899. USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. MT SINAI MED CTR,DEPT PHYSIOL & BIOPHYS,NEW YORK,NY 10029. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 30 TC 24 Z9 24 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD MAY 6 PY 1993 VL 97 IS 18 BP 4608 EP 4613 DI 10.1021/j100120a009 PG 6 WC Chemistry, Physical SC Chemistry GA LA766 UT WOS:A1993LA76600009 ER PT J AU HERBERS, JE AF HERBERS, JE TI SCREENING WITH PROSTATE-SPECIFIC ANTIGEN - SHOULD WE OR SHOULDNT WE SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP HERBERS, JE (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 2 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAY 5 PY 1993 VL 269 IS 17 BP 2212 EP 2212 DI 10.1001/jama.269.17.2212 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA KZ406 UT WOS:A1993KZ40600020 PM 7682633 ER PT J AU TERRY, AK DRAUGALIS, JR BOOTMAN, JL AF TERRY, AK DRAUGALIS, JR BOOTMAN, JL TI DRUG-USE EVALUATION PROGRAMS IN SHORT-TERM-CARE GENERAL HOSPITALS SO AMERICAN JOURNAL OF HOSPITAL PHARMACY LA English DT Article DE ADMINISTRATION; AMERICAN-SOCIETY-OF-HOSPITAL-PHARMACISTS; COMMITTEES; DATA COLLECTION; DRUG USE; GUIDELINES; HOSPITALS; PHARMACISTS, HOSPITAL; PHARMACY, INSTITUTIONAL, HOSPITAL ID ASHP NATIONAL SURVEY; PHARMACEUTICAL SERVICES AB The results of a survey to assess drug-use evaluation (DUE) programs in short-term-care general U.S. hospitals are reported. During February 1992, questionnaires were mailed to pharmacy directors at 491 randomly selected short-term-care general hospitals with 100 or more beds. The questionnaire was designed to collect information on the characteristics of surveyed hospitals and their pharmacies, DUE program characteristics, and the perceptions of pharmacists about the DUE programs. The net response rate was 66.6% (327 usable replies). Pharmacist involvement in DUE program activities was found to be very high, with two thirds of respondents indicating they participated in all five ASHP-recommended activities. Pharmacists rated the effectiveness of current DUE programs as moderate, while the importance of pharmacist participation was perceived to be very high. Pharmacists were members of 97.9% of the respondents' DUE committees, but only 65.5% of the pharmacist members held voting privileges. Pharmacists reported devoting an average of 11.27 hours weekly to DUE-related tasks. Reasons used to select drugs for DUEs, interventions employed, uses of DUE results, and methods of evaluating the effectiveness of DUE programs all varied widely. In short-term-care general hospitals with 100 or more beds, pharmacists assigned to DUE activities were highly involved in DUE committees and programs. The effectiveness of these activities needs to be assessed in more detail. C1 UNIV ARIZONA,TUCSON,AZ 85721. RP TERRY, AK (reprint author), US MIL ACAD,KELLER ARMY COMMUNITY HOSP,PHARM SERV,W POINT,NY 10996, USA. NR 12 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 0002-9289 J9 AM J HOSP PHARM JI Am. J. Hosp. Pharm. PD MAY PY 1993 VL 50 IS 5 BP 940 EP 944 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA LA584 UT WOS:A1993LA58400022 PM 8506873 ER PT J AU STEINWEG, DL WORTH, H AF STEINWEG, DL WORTH, H TI ALCOHOLISM - THE KEYS TO THE CAGE SO AMERICAN JOURNAL OF MEDICINE LA English DT Article ID QUESTIONNAIRE AB PURPOSE: To compare the efficiency of screening for alcoholism using two different introductions to the CAGE questions. PATIENTS. Forty-three alcoholics on inpatient medical and surgical services were identified through random distribution of the Michigan Alcoholism Screening Test. METHODS: Participants were randomized to two groups receiving different introductions to the CAGE questions. Group I was introduced by a simple open-ended question. Group II patients were asked first to quantitate the volume and frequency of their drinking. The outcome measures were the scores on the four CAGE questions recorded by an independent observer. RESULTS: Eighteen of 21 (86%) patients in Group I admitted to prior attempts to cut back on their drinking as compared with 8 of 22 (36%) in Group II (p = 0.002). Likewise 10 of 21 (49%) patients in the first group admitted to annoyance compared with just 3 of 22 (14%) in Group II. The average scores per patient in the two groups were significantly different. Group I = 2.52 versus Group II = 1.23 (p = 0.0002). Using a screening CAGE score of two or more to identify an alcoholic patient, the open-ended introduction identified 95% of the alcoholics compared with only 32% when the closed-ended introduction was used (p <0.0001). CONCLUSION: Our study demonstrates that the sensitivity of the CAGE questionnaire in screening for alcoholism is dramatically enhanced by an open-ended introduction. In contrast, the sensitivity of these questions is greatly reduced when preceded by inquiries that seek to define the quantity and frequency of drinking. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP STEINWEG, DL (reprint author), WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307, USA. NR 10 TC 83 Z9 85 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD MAY PY 1993 VL 94 IS 5 BP 520 EP 523 DI 10.1016/0002-9343(93)90088-7 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA LC874 UT WOS:A1993LC87400012 PM 8498397 ER PT J AU SPIRNAK, JP MONAHAN, DW AF SPIRNAK, JP MONAHAN, DW TI COLONIC DIAPHRAGMS ASSOCIATED WITH LONG-TERM USE OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Letter ID STRICTURES C1 WOMACK ARMY MED CTR,FT BRAGG,NC 28307. RP SPIRNAK, JP (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 4 TC 8 Z9 8 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAY PY 1993 VL 160 IS 5 BP 1148 EP 1149 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA KY249 UT WOS:A1993KY24900053 PM 8470601 ER PT J AU STANNARD, JP BUCKNELL, AL AF STANNARD, JP BUCKNELL, AL TI RUPTURE OF THE TRICEPS TENDON ASSOCIATED WITH STEROID INJECTIONS SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article RP STANNARD, JP (reprint author), USDA,WOMACK ARMY MED CTR,FT BRAGG,NC 28307, USA. NR 0 TC 83 Z9 86 U1 0 U2 0 PU AMER ORTHOPAEDIC SOC SPORT MED PI WALTHAM PA 230 CALVARY STREET, WALTHAM, MA 02154 SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD MAY-JUN PY 1993 VL 21 IS 3 BP 482 EP 485 DI 10.1177/036354659302100327 PG 4 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA LD141 UT WOS:A1993LD14100027 PM 8346768 ER PT J AU BRANTON, PA TAVASSOLI, FA AF BRANTON, PA TAVASSOLI, FA TI SPINDLE CELL EPITHELIOMA, THE SO-CALLED MIXED TUMOR OF THE VAGINA - A CLINICOPATHOLOGICAL, IMMUNOHISTOCHEMICAL, AND ULTRASTRUCTURAL ANALYSIS OF 28 CASES SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Article DE VAGINAL SPINDLE CELL EPITHELIOMA; MIXED TUMORS; EPITHELIAL TUMORS OF VAGINA ID PLEOMORPHIC ADENOMA; BREAST; RECEPTORS; POLYPS; CYSTS AB A total of 28 examples of vaginal mixed tumors, a circumscribed tumor composed predominantly of spindle cells, but often admixed with minor glandular, and focal areas of squamous differentiation along with localized hyaline globules, were evaluated. In addition to the clinicopathologic correlation with light microscopy, 10 cases were analyzed immunohistochemically by a panel of antibodies for keratin, smooth muscle actin, S-100 protein, and glial fibrillary acidic protein; five cases were also evaluated for estrogen and progesterone receptors. Ultrastructural analysis was performed on two tumors. The results indicate an epithelial differentiation in the predominating spindle cells based upon an intense immunoreaction with cytokeratin in nine of 10 cases and the presence of tonofilaments and desmosomes at the ultrastructural level. Contrary to mixed tumors of salivary gland and breast origin, no evidence of a myoepithelial differentiation was identified in these tumors. The name vaginal spindle cell epithelioma is proposed for these neoplasms as being more descriptive of the true nature of these tumors. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,AREA LAB SERV,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT GYNECOL & BREAST PATHOL,WASHINGTON,DC 20307. NR 20 TC 32 Z9 34 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD MAY PY 1993 VL 17 IS 5 BP 509 EP 515 DI 10.1097/00000478-199305000-00011 PG 7 WC Pathology; Surgery SC Pathology; Surgery GA KY379 UT WOS:A1993KY37900011 PM 7682380 ER PT J AU WELSH, CH WAGNER, PD REEVES, JT LYNCH, D CINK, TM ARMSTRONG, J MALCONIAN, MK ROCK, PB HOUSTON, CS AF WELSH, CH WAGNER, PD REEVES, JT LYNCH, D CINK, TM ARMSTRONG, J MALCONIAN, MK ROCK, PB HOUSTON, CS TI OPERATION EVEREST-II - SPIROMETRIC AND RADIOGRAPHIC CHANGES IN ACCLIMATIZED HUMANS AT SIMULATED HIGH-ALTITUDES SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article ID LUNG LYMPH-FLOW; EXTREME ALTITUDE; PULMONARY-EDEMA; EXERCISE; SHEEP AB We report spirometry and radiographic data on eight normal male human subjects during prolonged graded altitude exposure to as high as 8,848 m above sea level in a hypobaric chamber. We found a significant and progressive drop in FVC by 14 +/- 3% over 40 days, which resolved slowly during the first 48 h after descent. With altitude, midrange forced expiratory flow (FEF25-75) increased by 82 +/- 3%, probably because of reduced air density. FEV1, however, did not change. Chest radiographs on subjects taken 2 h after descent to sea level showed a pattern of pulmonary artery enlargement and interstitial edema. These data suggest that increased pulmonary blood volume and edema may be causes of the restricted pulmonary function pattern. C1 UNIV COLORADO,HLTH SCI CTR,DEPT RADIOL,DENVER,CO 80262. UNIV CALIF SAN DIEGO,DEPT MED,SAN DIEGO,CA 92103. UNIV COLORADO,HLTH SCI CTR,DEPT MED,DENVER,CO 80262. USA,ENVIRONM MED RES INST,DIV ALTITUDE,NATICK,MA 01760. UNIV VERMONT,BURLINGTON,VT. FU NHLBI NIH HHS [HL-14985, HL-17731] NR 27 TC 48 Z9 49 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD MAY PY 1993 VL 147 IS 5 BP 1239 EP 1244 PG 6 WC Respiratory System SC Respiratory System GA LJ666 UT WOS:A1993LJ66600028 PM 8484637 ER PT J AU HATCH, RT PARKER, JM ENGLER, RJM AF HATCH, RT PARKER, JM ENGLER, RJM TI WHEEZING, HYPOXIA, AND DYSPNEA IN A 62-YEAR-OLD WOMAN SO ANNALS OF ALLERGY LA English DT Article C1 WALTER REED ARMY MED CTR,PULM SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIAGNOST LAB IMMUNOL,WASHINGTON,DC 20307. RP HATCH, RT (reprint author), WALTER REED ARMY MED CTR,ALLERGY & IMMUNOL SERV,WASHINGTON,DC 20307, USA. NR 11 TC 1 Z9 1 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 SN 0003-4738 J9 ANN ALLERGY JI Ann. Allergy PD MAY PY 1993 VL 70 IS 5 BP 363 EP 367 PG 5 WC Allergy SC Allergy GA LD142 UT WOS:A1993LD14200003 PM 8498725 ER PT J AU JAPOUR, AJ MAYERS, DL JOHNSON, VA KURITZKES, DR BECKETT, LA ARDUINO, JM LANE, J BLACK, RJ REICHELDERFER, PS DAQUILA, RT CRUMPACKER, CS BALFOUR, H ERICE, A COOMBS, R KATZENSTEIN, D LATHEY, J RICHMAN, D MCINTOSH, K RANGAN, S REICHMAN, R SCOTT, W USSERY, M ABRAMS, L MCCUTCHAN, F BURKE, D GARDNER, L ROBERTS, C CHUNG, R HICKS, C SHELLIE, E FOWLER, A MERRITT, L FUJIMURAJUSTICE, M RUIZ, N WAGNER, K GAIL, M AF JAPOUR, AJ MAYERS, DL JOHNSON, VA KURITZKES, DR BECKETT, LA ARDUINO, JM LANE, J BLACK, RJ REICHELDERFER, PS DAQUILA, RT CRUMPACKER, CS BALFOUR, H ERICE, A COOMBS, R KATZENSTEIN, D LATHEY, J RICHMAN, D MCINTOSH, K RANGAN, S REICHMAN, R SCOTT, W USSERY, M ABRAMS, L MCCUTCHAN, F BURKE, D GARDNER, L ROBERTS, C CHUNG, R HICKS, C SHELLIE, E FOWLER, A MERRITT, L FUJIMURAJUSTICE, M RUIZ, N WAGNER, K GAIL, M TI STANDARDIZED PERIPHERAL-BLOOD MONONUCLEAR CELL-CULTURE ASSAY FOR DETERMINATION OF DRUG SUSCEPTIBILITIES OF CLINICAL HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATES SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID HIV-1 REVERSE-TRANSCRIPTASE; ZIDOVUDINE AZT; REDUCED SENSITIVITY; RESISTANT; INHIBITORS; THERAPY; INVITRO AB A standardized antiviral drug susceptibility assay for clinical human immunodeficiency virus type 1 (HIV-1) isolates has been developed for use in clinical trials. The protocol is a two-step procedure that first involves cocultivation of patient infected peripheral blood mononuclear cells (PBMC) with seronegative phytohemag-glutinin-stimulated donor PBMC to obtain an HIV-1 stock. The virus stock is titrated for viral infectivity (50% tissue culture infective dose) by use of serial fourfold virus dilutions in donor PBMC. A standardized inoculum of 1,000 50% tissue culture infective doses per 10(6) cells is used in the second step of the procedure to acutely infect seronegative donor PBMC in a 7-day microtiter plate assay with triplicate wells containing zidovudine (ZDV) concentrations ranging from 0 to 5.0 muM. The ZDV 50% inhibitory concentrations (IC50) for reference ZDV-susceptible and ZDV-resistant HIV-1 isolates ranged from 0.002 to 0.113 muM and from 0.15 to >5.0 muM, respectively. Use of this consensus protocol reduced interlaboratory variability for ZDV IC50 determinations with reference HIV-1 isolates. Among eight laboratories, the coefficient of variation ranged from 0.85 to 1.25 with different PBMC protocols and was reduced to 0.39 to 0.98 with the standardized assay. Among the clinical HIV-1 isolates assayed by the standardized drug susceptibility assay, the median ZDV IC50 increased gradually with more ZDV therapy. This protocol provides an efficient and reproducible means to assess the in vitro susceptibility to antiretroviral agents of virtually all clinical HIV-1 isolates. C1 WALTER REED ARMY INST RES, DEPT DIAGNOST RETROVIROL, ROCKVILLE, MD 20850 USA. USN, MED RES INST, ROCKVILLE, MD 20850 USA. SRA TECHNOL, ROCKVILLE, MD 20850 USA. UNIV ALABAMA, SCH MED, DIV INFECT DIS, BIRMINGHAM, AL 35294 USA. UNIV COLORADO, HLTH SCI CTR, DIV INFECT DIS, DENVER, CO 80262 USA. HARVARD UNIV, SCH PUBL HLTH, CTR STAT DATA ANAL, BOSTON, MA 02115 USA. NIAID, DIV AIDS, BETHESDA, MD 20892 USA. NATL NAVAL MED CTR, BETHESDA, MD 20814 USA. HARVARD UNIV, MASSACHUSETTS GEN HOSP E, SCH MED, INFECT DIS UNIT, BOSTON, MA 02129 USA. UNIV MINNESOTA, MINNEAPOLIS, MN 55455 USA. STANFORD UNIV, MED CTR, SCH MED, STANFORD, CA 94305 USA. UNIV WASHINGTON, SEATTLE, WA 98195 USA. UNIV CALIF SAN DIEGO, LA JOLLA, CA 92093 USA. HARVARD UNIV, CHILDRENS HOSP, SCH MED, BOSTON, MA 02115 USA. TULANE UNIV, MED CTR, NEW ORLEANS, LA 70118 USA. UNIV ROCHESTER, ROCHESTER, NY 14627 USA. UNIV MIAMI, SCH MED, MIAMI, FL 33152 USA. HENRY M JACKSON FDN, BETHESDA, MD USA. WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. RP JAPOUR, AJ (reprint author), HARVARD UNIV, BETH ISRAEL HOSP, SCH MED, DIV INFECT DIS, BOSTON, MA 02215 USA. OI /0000-0002-5704-8094 FU NIAID NIH HHS [AI 62534, AI 29173, AI 27659] NR 31 TC 249 Z9 259 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAY PY 1993 VL 37 IS 5 BP 1095 EP 1101 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA LA017 UT WOS:A1993LA01700028 PM 8517697 ER PT J AU DUEWEKE, TJ POPPE, SM ROMERO, DL SWANEY, SM SO, AG DOWNEY, KM ALTHAUS, IW REUSSER, F BUSSO, M RESNICK, L MAYERS, DI LANE, J ARISTOFF, PA THOMAS, RC TARPLEY, WG AF DUEWEKE, TJ POPPE, SM ROMERO, DL SWANEY, SM SO, AG DOWNEY, KM ALTHAUS, IW REUSSER, F BUSSO, M RESNICK, L MAYERS, DI LANE, J ARISTOFF, PA THOMAS, RC TARPLEY, WG TI U-90152, A POTENT INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID REVERSE-TRANSCRIPTASE INHIBITORS; NONNUCLEOSIDE INHIBITORS; HIV-1; DERIVATIVES; INFECTION; CELLS; AIDS; DNA AB Bisheteroarylpiperazines are potent inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). We describe a novel bisheteroarylpiperazine, U-90152 {1-(5-methanesulfonamido-1H-indol-2-yl-carbonyl)-4-[3-(1-methylethyl-amino)pyridinyl]piperazine}, which inhibited recombinant HIV-1 RT at a 50% inhibitory concentration (IC50) of 0.26 muM (compared with IC50s of >440 muM for DNA polymerases alpha and delta). U-90152 blocked the replication in peripheral blood lymphocyles of 25 primary HIV-1 isolates, including variants that were highly resistant to 3'-azido-2',3'-dideoxythymidine (AZT) or 2',3'-dideoxyinosine, with a mean 50% effective dose of 0.066 +/- 0.137 muM. U-90152 had low cellular cytotoxicity, causing less than 8% reduction in peripheral blood lymphocyte viability at 100 muM. In experiments assessing inhibition of the spread of HIV-1IIIB in cell cultures, U-90152 was much more effective than AZT. When approximately 500 HIV-1IIIB-infected MT-4 cells were mixed 1:1,000 with uninfected cells, 3 muM AZT delayed the evidence of rapid viral growth for 7 days. In contrast, 3 muM U-90152 totally prevented the spread of HIV-1, and death and/or dilution of the original inoculum of infected cells prevented renewed viral growth after U-90152 was removed at day 24. The combination of U-90152 and AZT, each at 0.5 muM, also totally prevented viral spread. Finally, although the RT amino acid substitutions K103N (lysine 103 to asparagine) and Y181C (tyrosine 181 to cysteine), which confer cross-resistance to several nonnucleoside inhibilors, also decrease the potency of U-90152, this drug retains significant activity against these mutant RTs in vitro (IC50s, approximately 8 muM). C1 UPJOHN CO LABS,KALAMAZOO,MI 49001. UNIV MIAMI,MIAMI,FL 33101. MT SINAI MED CTR,MILWAUKEE,WI 53233. WALTER REED ARMY INST RES,ROCKVILLE,MD 20850. USN,MED RES INST,ROCKVILLE,MD 20850. SRA TECHNOL,ROCKVILLE,MD 20850. NR 28 TC 132 Z9 135 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAY PY 1993 VL 37 IS 5 BP 1127 EP 1131 PG 5 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA LA017 UT WOS:A1993LA01700033 PM 7685995 ER PT J AU SAMLASKA, CP NOYES, DK AF SAMLASKA, CP NOYES, DK TI LOCALIZED CUTANEOUS REACTIONS TO GRANULOCYTE-COLONY-STIMULATING FACTOR SO ARCHIVES OF DERMATOLOGY LA English DT Letter C1 TRIPLER ARMY MED CTR,DEPT MED,HONOLULU,HI 96859. RP SAMLASKA, CP (reprint author), TRIPLER ARMY MED CTR,DERMATOL SERV,HONOLULU,HI 96859, USA. NR 5 TC 12 Z9 13 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD MAY PY 1993 VL 129 IS 5 BP 645 EP 646 DI 10.1001/archderm.129.5.645 PG 2 WC Dermatology SC Dermatology GA LB403 UT WOS:A1993LB40300020 PM 7683188 ER PT J AU AHLSTRAND, GM RACINE, CH AF AHLSTRAND, GM RACINE, CH TI RESPONSE OF AN ALASKA, USA, SHRUB-TUSSOCK COMMUNITY TO SELECTED ALL-TERRAIN-VEHICLE USE SO ARCTIC AND ALPINE RESEARCH LA English DT Article ID SOIL-PLANT SYSTEM; TUNDRA; DISTURBANCES AB Tests conducted at Wrangell-St. Elias National Park quantified the effects of all-terrain vehicle (ATV) use on a shrub-tussock community. Vehicle track depth increased significantly with increasing passes. Vehicles running on rubber tires created deeper tracks than similar vehicles mounted on continuous rubber tracks. Heavier ATVs usually produced deeper tracks than lighter vehicles. Deeper tracks resulted when vehicle use was spread over a 10-wk period during the summer than when the passes were concentrated into shorter time periods near the beginning or end of the snow-free period. Two years after completing the treatments, most of the heavier-used lanes had subsided 2 to 4 cm due to thawing of ice-rich permafrost. Although injury occurred to shrubs continuously throughout the treatments, shrub injury rates were greatest during the first few passes by an ATV. The dwarf shrubs Empetrum nigrum and Vaccinium vitis-idaea were least affected, while the low shrub Betula nana was most susceptible to injury. The degree of sedge tussock compression and amount of organic soil exposed along the ATV tracks increased in relation to vehicle weight. C1 NATL PK SERV,ANCHORAGE,AK 99503. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. NR 18 TC 5 Z9 5 U1 1 U2 5 PU INST ARCTIC ALPINE RES PI BOULDER PA UNIV COLORADO, BOULDER, CO 80309 SN 0004-0851 J9 ARCTIC ALPINE RES JI Arct. Alp. Res. PD MAY PY 1993 VL 25 IS 2 BP 142 EP 149 DI 10.2307/1551551 PG 8 WC Environmental Sciences; Geography SC Environmental Sciences & Ecology; Geography GA LC447 UT WOS:A1993LC44700008 ER PT J AU FINGER, DR PEDERSEN, RC KLIPPLE, GL AF FINGER, DR PEDERSEN, RC KLIPPLE, GL TI CNS VASCULITIS FOLLOWING CHICKENPOX - A CASE-REPORT AND REVIEW OF THE LITERATURE SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD MAY PY 1993 VL 36 IS 5 SU S BP R27 EP R27 PG 1 WC Rheumatology SC Rheumatology GA LD569 UT WOS:A1993LD56900125 ER PT J AU ALVES, D AF ALVES, D TI AUSTRALIA DEVELOPING RELATIONS WITH SOUTHEAST-ASIA SO ASIAN SURVEY LA English DT Article RP ALVES, D (reprint author), USA,WASHINGTON,DC 20310, USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0004-4687 J9 ASIAN SURV JI Asian Surv. PD MAY PY 1993 VL 33 IS 5 BP 520 EP 530 DI 10.1525/as.1993.33.5.00p02823 PG 11 WC Area Studies SC Area Studies GA LL866 UT WOS:A1993LL86600005 ER PT J AU FARR, WD AF FARR, WD TI FOR WANT OF A FLIGHT SURGEON SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Note AB In 1863, Captain John Randolph Bryan conducted the Confederate States Army's first military reconnaissance balloon flights. On his second flight, he survived a Class ''A'' aviation mishap. This article discusses the probable contributing mishap factors stemming from the lack of an effective aviation medicine program with appropriate flight surgeon input and participation. Physical standards, flying duty medical examinations, the Acceptability Rating for Military Aeronautics (ARMA), crew rest regulations, unit safety programs, physiological training, aviation life support equipment (ALSE), night vision training, survival training, and aircraft accident investigation are explored. RP FARR, WD (reprint author), USA,MC,AOCFP,AL,DIV CLIN SCI,BROOKS AFB,TX 78235, USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 1993 VL 64 IS 5 BP 405 EP 408 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA LA459 UT WOS:A1993LA45900011 PM 8503816 ER PT J AU PSOTKA, J KERST, S WESTERMAN, T AF PSOTKA, J KERST, S WESTERMAN, T TI THE USE OF HYPERTEXT AND SENSORY-LEVEL SUPPORTS FOR VISUAL LEARNING OF AIRCRAFT NAMES AND SHAPES SO BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS LA English DT Article; Proceedings Paper CT 22ND ANNUAL MEETING OF THE SOC FOR COMPUTERS IN PSYCHOLOGY CY NOV 12, 1992 CL ST LOUIS, MO SP SOC COMP PSYCHOL AB Hypertexts have many novel and unexplored features for representing, linking, and exploring knowledge to make it more useful for learning. We contrasted traditional textbook presentation of information against a hypertext that implemented database retrieval of text and manipulation of colored, bitmapped displays. Hypertext enabled us to explore the role of sensory-level supports, such as apparent motion and colored overlays, as aids for visual cognition and concept formation. One visible difference between traditional text and hypertext was in the use of a rapid browsing strategy by the hypertext learners, compared with a methodical, extended side-by-side comparison by the book learners. The research also discovered that students better learned local neighborhoods of concepts, as opposed to widely dispersed concepts, in the hypertext environment. We selected visual aircraft recognition (VACR) as a topical area for the research because it is a very important problem in the Army, because traditional VACR training emphasizes both text and images, and because we had available to us a fine manual (Army Field Manual FM 44-30) full of black-and-white pictures and text that was artfully arranged on the page, as well as access to hundreds of color slides of airplanes. Our research found superior learning with the hypertext field manual, and we examined higher order learning strategies, such as depth-first versus breadth-first paths through the hierarchy of knowledge, and sensory-level supports for learning within these environments. C1 CATHOLIC UNIV AMER,WASHINGTON,DC 20064. RP PSOTKA, J (reprint author), USA,RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 9 TC 9 Z9 9 U1 0 U2 0 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0743-3808 J9 BEHAV RES METH INSTR JI Behav. Res. Methods Instr. Comput. PD MAY PY 1993 VL 25 IS 2 BP 168 EP 172 DI 10.3758/BF03204490 PG 5 WC Psychology, Mathematical; Psychology, Experimental SC Psychology GA LD498 UT WOS:A1993LD49800011 ER PT J AU HOLLINGER, J AF HOLLINGER, J TI STRATEGIES FOR REGENERATING BONE OF THE CRANIOFACIAL COMPLEX SO BONE LA English DT Article; Proceedings Paper CT 6TH INTERNATIONAL MEETING ON BONE MORPHOMETRY CY OCT 04-09, 1992 CL LEXINGTON, KY SP ABBOTT LABS, BOEHRINGER MANNHEIM, CHUGAI PHARM, CIBA GEIGY, DIALYSIS CLIN, INTERMED ORTHOPED, RHONE POULENC RORER, SANDOZ PHARM, STRAUMANN, DEPUY ID POROUS HYDROXYAPATITE; GRAFT SUBSTITUTE; GROWTH-FACTORS; TRICALCIUM PHOSPHATE; BOVINE BONE; INDUCTION; RECONSTRUCTION; OSTEOGENESIS; OSSIFICATION; INITIATION C1 WALTER REED ARMY MED CTR,USAIDR,WASHINGTON,DC 20307. NR 51 TC 13 Z9 13 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 8756-3282 J9 BONE JI Bone PD MAY-JUN PY 1993 VL 14 IS 3 BP 575 EP 580 DI 10.1016/8756-3282(93)90196-H PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA LD833 UT WOS:A1993LD83300059 PM 8363908 ER PT J AU JAMES, WF BARKO, JW AF JAMES, WF BARKO, JW TI SEDIMENT RESUSPENSION, REDEPOSITION, AND FOCUSING IN A SMALL DIMICTIC RESERVOIR SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES LA English DT Article ID TURBULENT FLOWS; POLLEN GRAINS; LAKE SEDIMENT; TRAP BIASES; PHOSPHORUS; REDISTRIBUTION; ACCUMULATION; RETENTION; WIND AB Rates of seston (dry mass) sedimentation, estimated from sediment traps (ST rates) and sediment cores (SC rates), were determined at four water depths to examine seasonal and annual sedimentation patterns in Eau Galle Reservoir, Wisconsin (USA). Annual ST rates overestimated annual SC rates at water depths less-than-or-equal-to 4 m, suggesting that sediment resuspension and redeposition in relatively shallow regions of the reservoir caused the overestimate. In contrast, annual ST and SC rates were similar at depths >4 m, suggesting minimal sediment resuspension and redeposition in deeper regions of the reservoir. Using variations in daily ST rates estimated during the autumn overturn of 1987, we developed a conceptual framework for estimating sediment resuspension, redeposition, and focusing. Resuspension of shallow sediments during this particular period accounted for over 50% of the annual ST rate at depths less-than-or-equal-to 4 m. At the same time, focusing of resuspended shallow sediments to deeper regions accounted for about 20% of the annual ST rate at depths >4 m. Our results indicate that during autumn overturn in this reservoir, peaks in sedimentation in the deep, profundal region, estimated from sediment traps, may reflect sediment focused from shallow regions rather than sediment resuspended from the profundal region. C1 ENVIRONM LAB, WATERWAYS EXPT STN, VICKSBURG, MS 39180 USA. RP JAMES, WF (reprint author), EAU GALLE LIMNOL LAB, WATERWAYS EXPT STN, POB 237, SPRING VALLEY, WI 54767 USA. NR 30 TC 27 Z9 27 U1 0 U2 5 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA SN 0706-652X EI 1205-7533 J9 CAN J FISH AQUAT SCI JI Can. J. Fish. Aquat. Sci. PD MAY PY 1993 VL 50 IS 5 BP 1023 EP 1028 DI 10.1139/f93-118 PG 6 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA LR758 UT WOS:A1993LR75800017 ER PT J AU MARION, GM VANCLEVE, K DYRNESS, CT AF MARION, GM VANCLEVE, K DYRNESS, CT TI CALCIUM-CARBONATE PRECIPITATION DISSOLUTION ALONG A FOREST PRIMARY SUCCESSIONAL SEQUENCE ON THE TANANA RIVER FLOODPLAIN, INTERIOR ALASKA SO CANADIAN JOURNAL OF FOREST RESEARCH LA English DT Article ID ACIDIFICATION; ECOSYSTEMS; SOILS AB Calcareous (alkaline) soils exist along the river floodplains of interior Alaska. In calcareous soils, the balance of CaCO3 reflects net system acidification-alkalinization. The objectives of this study were to determine the origin of the CaCO3, quantify CaCO3 precipitation-dissolution, and quantify net system acidification alkalinization along a forest primary successional sequence (250 years) on the Tanana River floodplain of interior Alaska. The CaCO3 concentrations in the initial soil profiles were positively correlated (R2 = 0.883) with silt concentrations. Differences in CaCO3 concentrations in the early soil profiles between sites of similar age, between forest successional stages, and among soil horizons within a profile are primarily due to differences in silt concentrations, which are controlled by the alluvial deposition process. There was a curvilinear decrease in CaCO3 content along the forest successional sequence, suggesting that the CaCO3 originated with the alluvial material and was not formed in situ. The loss of CaCO3 was equivalent to a loss of acid-neutralizing capacity of 10.0 kequiv . ha-1 . year-1, which is a high rate of soil acidification. These forested, relatively pristine ecosystems are dominated by internal sources of acidity. C1 UNIV ALASKA, FOREST SOILS LAB, FAIRBANKS, AK 99775 USA. US FOREST SERV, INST NO FORESTRY, FAIRBANKS, AK 99775 USA. RP USA, CORPS ENGINEERS, COLD REG RES & ENGN LAB, 72 LYME RD, HANOVER, NH 03755 USA. NR 24 TC 13 Z9 13 U1 1 U2 1 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA SN 0045-5067 EI 1208-6037 J9 CAN J FOREST RES JI Can. J. For. Res. PD MAY PY 1993 VL 23 IS 5 BP 923 EP 927 DI 10.1139/x93-120 PG 5 WC Forestry SC Forestry GA LQ390 UT WOS:A1993LQ39000020 ER PT J AU VANCLEVE, K VIERECK, LA MARION, GM AF VANCLEVE, K VIERECK, LA MARION, GM TI INTRODUCTION AND OVERVIEW OF A STUDY DEALING WITH THE ROLE OF SALT-AFFECTED SOILS IN PRIMARY SUCCESSION ON THE TANANA RIVER FLOODPLAIN, INTERIOR ALASKA SO CANADIAN JOURNAL OF FOREST RESEARCH-REVUE CANADIENNE DE RECHERCHE FORESTIERE LA English DT Article AB This paper provides an overview of the environmental setting, rationale, and organization of a multidisciplinary research program designed to examine the role of salt-affected soils in primary succession on the Tanana River floodplain of interior Alaska. The papers included in this series report results of studies designed to examine the controls of salt-affected soil formation and vegetation development and their interaction in this fluvial environment. The association of pedogenic salts and forests is largely restricted to northern latitudes where both low precipitation and moderate potential evapotranspiration occur simultaneously. In contrast with upland secondary-successional sites, where fire is the principal determinant of forest type distribution and successional change, ecosystem processes on the floodplain are determined by the fluvial nature of the environment. Consequently, the research presented an opportunity to evaluate some of the markedly contrasting controls of development that exist between forests in the two topographic locations. This study makes a substantial contribution to our understanding of how soil and vegetation interact on interior Alaskan floodplains to give rise to productive, commercially valuable forests. C1 US FOREST SERV,INST NO FORESTRY,FAIRBANKS,AK 99775. USA,CORPS ENGINEERS,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP VANCLEVE, K (reprint author), UNIV ALASKA,FOREST SOILS LAB,FAIRBANKS,AK 99775, USA. NR 25 TC 29 Z9 29 U1 0 U2 1 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0045-5067 J9 CAN J FOREST RES JI Can. J. For. Res.-Rev. Can. Rech. For. PD MAY PY 1993 VL 23 IS 5 BP 879 EP 888 PG 10 WC Forestry SC Forestry GA LQ390 UT WOS:A1993LQ39000016 ER PT J AU MARION, GM VANCLEVE, K DYRNESS, CT BLACK, CH AF MARION, GM VANCLEVE, K DYRNESS, CT BLACK, CH TI THE SOIL CHEMICAL ENVIRONMENT ALONG A FOREST PRIMARY SUCCESSIONAL SEQUENCE ON THE TANANA RIVER FLOODPLAIN, INTERIOR ALASKA SO CANADIAN JOURNAL OF FOREST RESEARCH-REVUE CANADIENNE DE RECHERCHE FORESTIERE LA English DT Article ID SOLUBILITIES AB Alkaline soils exist under forest vegetation on the Tanana River floodplain of interior Alaska. The objectives of this study were to describe the soil chemical properties and to examine controls oil these chemical properties along a forest primary-successional sequence. Soil saturation pastes were prepared from duplicate sites along the successional sequence representing bare alluvium (stage I), open willow (stage III), poplar alder (stage V), and white spruce (stage VIII). Calcium, Mg, SO4, and ions responsible for alkalinity were the dominant solutes in the saturation extracts. Soil horizons were generally calcareous (CaCO3) and therefore alkaline (pH > 7.0) across the successional sequence. The CaCO3-containing soil horizons were saturated to supersaturated with respect to calcite. Many soil horizons in the plots of stages III and V from one site were saturated with respect to gypsum (CaSO4.2H2O), whereas other stages and sites were generally undersaturated. Phosphate availability in CaCO3-containing soil horizons was apparently constrained by CaCO3 solubility and the solubility products of beta-tricalcium phosphate and hydroxyapatite. There was a strong positive relationship between soluble salt content and silt concentration in the early stages, suggesting that initial salt content is controlled by the texture of the alluvial material: the variation in initial texture largely accounts for the site to site variation in salts. Evaporation apparently plays a role in concentrating soluble salts at the surface during the early stages (III and V), but by the late stages (VIII), the biotic and topographic factors apparently reduce surficial evaporation. This reduction in evaporation, coupled with the production of organic acids, leads to a 42% loss of soluble salts from the soils. This study supports our original hypotheses that physical factors (texture, evaporation) are most important early in the successional sequence and that biotic factors (transpiration, acid leaching) are most important late in the successional sequence in controlling salt distribution in soils on the Tanana River C1 UNIV ALASKA,FOREST SOILS LAB,FAIRBANKS,AK 99775. US FOREST SERV,INST NO FORESTRY,FAIRBANKS,AK 99775. SAN DIEGO STATE UNIV,DEPT BIOL,SAN DIEGO,CA 92182. RP MARION, GM (reprint author), USA,CORPS ENGINEERS,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 36 TC 23 Z9 23 U1 0 U2 1 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0045-5067 J9 CAN J FOREST RES JI Can. J. For. Res.-Rev. Can. Rech. For. PD MAY PY 1993 VL 23 IS 5 BP 914 EP 922 DI 10.1139/x93-119 PG 9 WC Forestry SC Forestry GA LQ390 UT WOS:A1993LQ39000019 ER PT J AU VANCLEVE, K DYRNESS, CT MARION, GM ERICKSON, R AF VANCLEVE, K DYRNESS, CT MARION, GM ERICKSON, R TI CONTROL OF SOIL DEVELOPMENT ON THE TANANA RIVER FLOODPLAIN, INTERIOR ALASKA SO CANADIAN JOURNAL OF FOREST RESEARCH-REVUE CANADIENNE DE RECHERCHE FORESTIERE LA English DT Article AB Alluvial soils on the Tanana River floodplain near Fairbanks, Alaska, were examined for development of physical and chemical properties in relation to soil depth and across a 200-year vegetation development sequence. Development was mediated by ecosystem controls including successional time, vegetation, terrace height, soil physical and chemical properties, and microclimate. These controls interact and are conditioned by the state factors time, flora, topography, parent material, and climate, respectively. On early-successional (<5 years) lower alluvial surfaces, terrace height above groundwater, soil particle size, and microclimate (through soil surface evaporation) interacted through capillary rise to produce salt-affected surface soil. Calcium salts of carbonate and sulfate were the principal chemicals encountered in these soils. Establishment of a vegetation cover between 5 and 10 years introduced evapotranspiration as a new mechanism, along with capillarity, to control moisture suction gradients. In addition, newly formed surface litter layers further helped eliminate evaporation and formation of high salt content surface soil. Continued sedimentation raised terrace elevation, so on older terraces only infrequent flood events influenced soil development. Moreover, in these successional stages, only the highest river stages raised groundwater levels, so transpiration and capillarity influenced water movement to tree root systems. During the first 25-30 years of succession, plant deposition of organic matter and nitrogen, associated with the growth of alder, markedly changed soil properties. Nearly 60% (or 240 g . m-2) of the 400 g. m-2 nitrogen encountered at 100 years was accumulated during this early period. After 100 years of vegetation development, soil carbonate content dropped to about half the peak values of about 1600 g. m-2 encountered between 4 and 25 years. By the time white spruce was the dominant forest type at 180 years, carbonate carbon declined to about 500 g . m-2, one-third that of the 1600 g . m-2 high. By this time surface soil pH declined from high values of 7.5 to between 5.5 and 6.0. Organic carbon continued to accumulate to about 6300 g . m-2 in the white spruce stage. twice that encountered in the alder poplar stage at 25 years. Indices of moisture retention were most strongly related to either soil particle size (low moisture tension and available moisture range) or vegetation-mediated soil organic matter content (high moisture tension). Cation exchange capacity was most strongly related to a vegetation-mediated index of organic matter (OM) content (%N, %C, or %OM). C1 US FOREST SERV,INST NO FORESTRY,FAIRBANKS,AK 99775. USA,CORPS ENGINEERS,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP VANCLEVE, K (reprint author), UNIV ALASKA,FOREST SOILS LAB,FAIRBANKS,AK 99775, USA. NR 30 TC 56 Z9 56 U1 3 U2 8 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0045-5067 J9 CAN J FOREST RES JI Can. J. For. Res.-Rev. Can. Rech. For. PD MAY PY 1993 VL 23 IS 5 BP 941 EP 955 PG 15 WC Forestry SC Forestry GA LQ390 UT WOS:A1993LQ39000022 ER PT J AU MALCOLM, DS FRIEDLAND, M MOORE, T BEAUREGARD, J HUFNAGEL, H WIESMANN, WP AF MALCOLM, DS FRIEDLAND, M MOORE, T BEAUREGARD, J HUFNAGEL, H WIESMANN, WP TI HYPERTONIC SALINE RESUSCITATION DETRIMENTALLY AFFECTS RENAL-FUNCTION AND SURVIVAL IN DEHYDRATED RATS SO CIRCULATORY SHOCK LA English DT Article DE 7.5-PERCENT SALINE; HEMORRHAGE; RENAL ARTERY OCCLUSION; MEAN ARTERIAL PRESSURE; INULIN CLEARANCE; RINGERS LACTATE; SURVIVAL MORTALITY ID SMALL-VOLUME RESUSCITATION; SEVERE HEMORRHAGIC-SHOCK; HYPEROSMOTIC NACL; SODIUM-CHLORIDE; PORCINE MODEL; BLOOD-FLOW; SWINE; HEMODYNAMICS; DEXTRAN-70; EFFICACY AB The purpose of our studies was to determine whether hypertonic (7.5%) saline (HTS) resuscitation is effective in the setting of dehydration. We compared the effects of HTS (5 cc/kg) to those of Ringer's lactate (RL; 45 cc/kg) on renal function, following resuscitation from hypovolemia in hydrated (free access to food/water) vs. dehydrated (food/water restricted) rats (30-350 g). Renal failure was produced by hemorrhage (15 cc/kg) plus renal artery occlusion (25 min) followed by fluid resuscitation. Dehydration was confirmed by hemoconcentration and weight loss (8-10%). Renal function was assessed at 24 hr using C-14-inulin clearance (C(in)) measurements. In hydrated animals, the C(in) of RL-treated rats (625 +/- 54 mu/min/100 g; n = 12) was no different from the C(in) in HTS-treated rats (517 +/- 48 mul/min/100 g; n = 13). Among dehydrated rats, C(in) in HTS-treated rats (n = 6) was significantly lower (P less-than-or-equal-to 0.05) than in RL-treated rats (n = 5) (117 +/- 33 mul/min/100 g vs. 542 +/- 84 mul/min/100 g, respectively). C(in) in dehydrated RL-treated rats was not significantly different from that in hydrated RL-treated rats. Furthermore, in dehydrated animals, nine of nine resuscitated with RL survived, compared to six of 13 resuscitated with HTS. All hydrated animals survived. In summary, renal failure was ameliorated by RL and worsened by HTS resuscitation in dehydrated rats. Furthermore, mortality was increased in dehydrated animals resuscitated with HTS compared to RL. C1 WALTER REED ARMY INST RES,DIV SURG,WASHINGTON,DC 20307. RP MALCOLM, DS (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 28 TC 10 Z9 11 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0092-6213 J9 CIRC SHOCK JI Circ. Shock PD MAY PY 1993 VL 40 IS 1 BP 69 EP 74 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA LB560 UT WOS:A1993LB56000010 PM 8324892 ER PT J AU GAGLIARDI, JA ELINE, MJ AF GAGLIARDI, JA ELINE, MJ TI MINIMAL PLAIN FILM FINDINGS OF A FEMORAL-NECK OSTEOID OSTEOMA DIAGNOSED BY RADIONUCLIDE BONE-SCINTIGRAPHY AND MRI SO CLINICAL NUCLEAR MEDICINE LA English DT Note AB This is a report of scintigraphy and MRI being used to define the vascularity, bone turnover, and secondary marrow changes produced by osteoid osteomas, thus accelerating diagnosis and treatment. RP GAGLIARDI, JA (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD MAY PY 1993 VL 18 IS 5 BP 446 EP 447 DI 10.1097/00003072-199305000-00020 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA LA837 UT WOS:A1993LA83700020 PM 8508586 ER PT J AU DIMARCO, RL DUGAN, JP MARTIN, WW TUCKER, WB AF DIMARCO, RL DUGAN, JP MARTIN, WW TUCKER, WB TI SEA-ICE FLEXURAL RIGIDITY - A COMPARISON OF METHODS SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article AB Mechanical properties of sea ice are typically determined from a static test using the physical and chemical properties of small samples. A series of measurements of flexural properties of multi-year sea ice were made recently using both a static and a dynamic geophysical technique. This paper presents the results of a comparison between the ice flexural rigidity determined by the two methods. The dynamic method is shown to yield a very precise determination of the flexural rigidity based upon the propagation of low frequency (1 to 70 Hz) waves. Values determined by the static method are shown to be consistently higher, at a high level of significance. C1 USA,CRREL,HANOVER,NH 03755. RP DIMARCO, RL (reprint author), ARETE ASSOCIATES,POB 16287,ARLINGTON,VA 22215, USA. NR 16 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD MAY PY 1993 VL 21 IS 3 BP 247 EP 255 DI 10.1016/0165-232X(93)90068-J PG 9 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA LC886 UT WOS:A1993LC88600004 ER PT J AU HAYNES, FD KERR, AD MARTINSON, CR AF HAYNES, FD KERR, AD MARTINSON, CR TI EFFECT OF FATIGUE ON THE BEARING CAPACITY OF FLOATING ICE SHEETS SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article AB Laboratory tests on floating freshwater ice covers with specially built pulsators are described. Preliminary tests showed that the creep deflections were very small and that the pulsator used did not cause a breakthrough on its own in the time frame considered. Therefore, a breakthrough method was used to determine the effect of the oscillatory load on the bearing capacity of an ice cover. After a prescribed time (or a number of accumulated cycles) both loading devices, the pulsator and its static control, were subjected to a constant downward deflection rate by means of screwjacks until breakthrough occurred. Two series of tests were conducted, one at an oscillating frequency of 21.5 Hz and the other at 15 Hz. Results of both series of test showed that the oscillations substantially lowered the bearing capacity of the ice covers tested. C1 UNIV DELAWARE,DEPT CIVIL ENGN,NEWARK,DE 19716. RP HAYNES, FD (reprint author), USA,COLD REG RES & ENGN LAB,ICE ENGN RES BRANCH,HANOVER,NH 03755, USA. NR 8 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD MAY PY 1993 VL 21 IS 3 BP 257 EP 263 DI 10.1016/0165-232X(93)90069-K PG 7 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA LC886 UT WOS:A1993LC88600005 ER PT J AU LEBEAU, GJ RAY, SE ALIABADI, SK TEZDUYAR, TE AF LEBEAU, GJ RAY, SE ALIABADI, SK TEZDUYAR, TE TI SUPG FINITE-ELEMENT COMPUTATION OF COMPRESSIBLE FLOWS WITH THE ENTROPY AND CONSERVATION VARIABLES FORMULATIONS SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article ID ADVECTIVE-DIFFUSIVE SYSTEMS; FLUID-DYNAMICS; EQUATIONS; OPERATOR; EULER AB SUPG-stabilized finite element formulations of compressible Euler equations based on the conservation and entropy variables are investigated and compared. The formulation based on the conservation variables consists of the formulation introduced by Tezduyar and Hughes plus a shock capturing term. The formulation based on the entropy variables is the same as the one by Hughes, Franca and Mallet, which has a shock capturing term built in. These formulations are tested on several subsonic, transonic and supersonic compressible flow problems. It is shown that the stabilized formulation based on the conservation variables gives solutions which are just as good as those obtained with the entropy variables. Furthermore, the solutions obtained using the two formulations are very close and in some cases almost indistinguishable. Consequently, it can be deduced that the relative mer-its of these two formulations will continue to remain under debate. C1 UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,1200 WASHINGTON AVE S,MINNEAPOLIS,MN 55415. UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,DEPT AEROSP ENGN & MECH,MINNEAPOLIS,MN 55415. NASA,LYNDON B JOHNSON SPACE CTR,DIV NAVIGAT CONTROL & AERONAUT,COMP FLUID DYNAM GRP,HOUSTON,TX 77058. RI Tezduyar, Tayfun/F-6134-2012 OI Tezduyar, Tayfun/0000-0001-8707-3162 NR 13 TC 77 Z9 77 U1 1 U2 2 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0045-7825 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD MAY PY 1993 VL 104 IS 3 BP 397 EP 422 DI 10.1016/0045-7825(93)90033-T PG 26 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA LC132 UT WOS:A1993LC13200006 ER PT J AU CARROUGHER, JG KADAKIA, S SHAFFER, RT BARRILLEAUX, C AF CARROUGHER, JG KADAKIA, S SHAFFER, RT BARRILLEAUX, C TI VENOUS COMPLICATIONS OF MIDAZOLAM VERSUS DIAZEPAM SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID UPPER GASTROINTESTINAL ENDOSCOPY; DOUBLE-BLIND; INTRAVENOUS DIAZEPAM; SEDATION; PREMEDICATION; COLONOSCOPY; DENTISTRY; CROSSOVER AB Although some studies have suggested fewer venous complications are associated with midazolam than with diazepam for endoscopic procedures, this variable has not been well documented. We prospectively evaluated the incidence of venous complications after intravenous injection of diazepam or midazolam in 122 consecutive patients undergoing colonoscopy and esophagogastroduodenoscopy. Overall, venous complications were more frequent with diazepam (22 of 62 patients) than with midazolam (4 of 60 patients) (p < 0.001). A palpable venous cord was present in 23% (14 of 62) of patients in the diazepam group, compared with 2% (1 of 60 patients) in the midazolam group (p < 0.002). Pain at the injection site occurred in 35% (22 of 62) of patients in the diazepam group compared with 7% (4 of 60 patients) in the midazolam group (p < 0.001). Swelling and warmth at the injection site were not significantly different between the two groups. Smoking, nonsteroidal anti-inflammatory drug use, intravenous catheter site, dwell time of the needle, alcohol use, and pain during the injection had no effect on the incidence of venous complications. C1 BROOKE ARMY MED CTR,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234. NR 17 TC 15 Z9 15 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAY-JUN PY 1993 VL 39 IS 3 BP 396 EP 399 DI 10.1016/S0016-5107(93)70113-3 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA LE878 UT WOS:A1993LE87800008 PM 8514073 ER PT J AU KEPCZYK, T KADAKIA, SC PARKER, A PINKSTON, T AF KEPCZYK, T KADAKIA, SC PARKER, A PINKSTON, T TI EFFECT OF INTRAVENOUS ERYTHROMYCIN ON GASTRIC-EMPTYING SO GASTROINTESTINAL ENDOSCOPY LA English DT Letter ID MOTILIN RP KEPCZYK, T (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX 78234, USA. NR 8 TC 1 Z9 2 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAY-JUN PY 1993 VL 39 IS 3 BP 469 EP 470 DI 10.1016/S0016-5107(93)70141-8 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA LE878 UT WOS:A1993LE87800035 PM 8514093 ER PT J AU RECHTIEN, RD HAMBACKER, KL BALLARD, RF AF RECHTIEN, RD HAMBACKER, KL BALLARD, RF TI A HIGH-FREQUENCY SPARKER SOURCE FOR THE BOREHOLE ENVIRONMENT SO GEOPHYSICS LA English DT Article ID SEISMOLOGY; ROCKS AB For tomographic investigations of shallow subsurface features of limited lateral extent, a high-frequency, low-cost borehole seismic source would be highly desirable, particularly for investigators with limited budgets. We constructed a simple, arc-discharge seismic source from off-the-shelf items. This source consists of a salt water filled bottle containing exposed conductors of a coaxial cable, across which 1 00 to 300 joules of electrical power were discharged. This source produced a seismic pulse with a dominant frequency in the neighborhood of 1.5 kHz and a half-power bandwidth in excess of 1 kHz. Repeatability of seismic signatures in a variety of environmental settings was excellent. Sufficient power was generated to observe seismic signals with at least a 35 dB signal-to-noise ratio at horizontal borehole separations of 100 m. For a borehole separation of 33.2 m, signals with at least a 35 dB signal-to-noise ratio were observed at angular ranges in the vertical plane to 68 degrees. The hydrostatic head limit for this source was determined to be approximately 430 m. C1 UNIV MISSOURI,DEPT ELECT ENGN,ROLLA,MO 65401. USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP RECHTIEN, RD (reprint author), UNIV MISSOURI,DEPT GEOL & GEOPHYS,ROLLA,MO 65401, USA. NR 12 TC 11 Z9 11 U1 0 U2 1 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD MAY PY 1993 VL 58 IS 5 BP 660 EP 669 DI 10.1190/1.1443450 PG 10 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA LC361 UT WOS:A1993LC36100006 ER PT J AU LEE, CS NALBANDIAN, V AF LEE, CS NALBANDIAN, V TI IMPEDANCE MATCHING OF A DUAL-FREQUENCY MICROSTRIP ANTENNA WITH AN AIR-GAP SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Note AB A novel microstrip antenna has been proposed to operate at dual frequencies. The microstrip is a single layer patch with nonradiating edges closed with a conducting foil. Resonant frequencies are altered by varying the air pp under the patch. The separation of the resonant frequencies can be nearly zero and has no upper limit in principle. The input impedance is easily matched by shifting the air pp. The radiation patterns are not affected by modification for dual-frequency operation. C1 USA,CECOM,INTELLIGENCE & ELECTR WARFARE DIRECTORATE,FT MONMOUTH,NJ 07703. RP LEE, CS (reprint author), SO METHODIST UNIV,DEPT ELECT ENGN,DALLAS,TX 75275, USA. NR 12 TC 4 Z9 7 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD MAY PY 1993 VL 41 IS 5 BP 680 EP 682 DI 10.1109/8.222288 PG 3 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA LN729 UT WOS:A1993LN72900018 ER PT J AU LUDWIG, R YOU, Z PALANISAMY, R AF LUDWIG, R YOU, Z PALANISAMY, R TI NUMERICAL SIMULATIONS OF AN ELECTROMAGNETIC ACOUSTIC TRANSDUCER RECEIVER SYSTEM FOR NDT APPLICATIONS SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article ID EMAT DESIGNS AB Development of a novel multistage numerical model of an electromagnetic acoustic transducer (EMAT), with particular emphasis on an EMAT receiver is presented. This model includes five separate modeling states, i.e. 1) static magnetic field simulation of an electromagnet, 2) pulsed eddy current distribution of a generic meander-line coil suspended over a conducting specimen, 3) Lorentz force distribution due to the interaction of the static magnetic field with the eddy current distributions, 4) acoustic wave generation and propagation based on the dynamic Lorentz forces, and 5) acoustic wave detection by an EMAT receiver. In particular, this paper describes how the transient particle displacement fields are converted into an induced voltage response as part of the EMAT receiver system. Numerical simulations show that the voltage response is dependent on the wire spacing of the receiver coil. C1 TIMKEN CO,CANTON,OH 44607. UNIV KASSEL,KASSEL,GERMANY. HEWLETT PACKARD CORP,ANDOVER,MA. USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP LUDWIG, R (reprint author), WORCESTER POLYTECH INST,DEPT ELECT & COMP ENGN,WORCESTER,MA 01609, USA. NR 26 TC 36 Z9 42 U1 3 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD MAY PY 1993 VL 29 IS 3 BP 2081 EP 2089 DI 10.1109/20.211323 PG 9 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA LC852 UT WOS:A1993LC85200003 ER PT J AU KOSINSKI, JA LU, YC BALLATO, A AF KOSINSKI, JA LU, YC BALLATO, A TI PURE-MODE LOCI IN PIEZOELECTRIC PLATE RESONATORS - APPLICATION TO MATERIALS EVALUATION IN CLASS 4MM SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article AB The accuracy of piezoelectric materials evaluations can be enhanced by the use of pure-mode orientations, provided that exact analytic expressions for the pure-mode eigenvalues are known. The accuracy is enhanced by eliminating the need to extract constants from the differences in sums and products of measured quantities. Previous studies of pure-mode loci have not addressed the need for an engineering methodology for pure-mode sample set selection for materials evaluation. In light of this, it has been found necessary to adopt an alternate approach for determining the pure-mode loci in piezoelectric crystals. The alternate approach yields simple analytic expressions for the stiffness eigenvalues and provides a convenient engineering methodology for pure-mode sample set selection. The paper reviews the theory of simple thickness modes in piezoelectric plate vibrators, the alternate approach to the determination of pure-mode loci and its application to pure-mode sample set selection for dilithium tetraborate is presented, and thickness- and lateral-field excitation considerations are discussed. C1 RUTGERS UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. RP KOSINSKI, JA (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 13 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD MAY PY 1993 VL 40 IS 3 BP 258 EP 264 DI 10.1109/58.216839 PG 7 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA LG561 UT WOS:A1993LG56100009 PM 18263180 ER PT J AU HICKMAN, CJ STOVER, CK JOSEPH, SW OAKS, EV AF HICKMAN, CJ STOVER, CK JOSEPH, SW OAKS, EV TI MURINE T-CELL RESPONSE TO NATIVE AND RECOMBINANT PROTEIN ANTIGENS OF RICKETTSIA-TSUTSUGAMUSHI SO INFECTION AND IMMUNITY LA English DT Article ID HEAT-SHOCK PROTEIN; MOLECULAR-CLONING; MYCOBACTERIUM-TUBERCULOSIS; FRANCISELLA-TULARENSIS; SEQUENCE-ANALYSIS; ESCHERICHIA-COLI; B-CELL; CYTOKINE PRODUCTION; GAMMA-INTERFERON; STRESS PROTEINS AB A polyclonal T-cell line with TH1 characteristics was used to assess the murine cellular immune response to native and recombinant Rickettsia tsutsugamushi antigens. Proliferation of this T-cell line was observed in response to numerous native antigen fractions, which indicates that the murine T-helper-cell response is directed at multiple scrub typhus antigens with no apparent antigenic immunodominance. Subsequent analysis of recombinant R. tsutsugamushi antigens made it possible to identify a 47-kDa scrub typhus antigen (Sta47) that was stimulatory for the polyclonal T-cell line. Recombinant clones encoding 56-, 58-, and 110-kDa antigens (Sta56, Sta58, and Sta110, respectively) were unable to induce proliferation of this T-cell line. DNA sequence analysis of the cloned rickettsial insert encoding the Sta47 protein revealed the presence of four open reading frames potentially encoding proteins of 47, 30, 18, and 13 kDa. Analysis of sodium dodecyl sulfate-polyacryl-amide gel electrophoresis-separated and eluted fractions of lysates from the recombinant HB101(pRTS47B4.3) demonstrated that the fractions containing the 47-kDa protein as well as those containing proteins less than 18 kDa were stimulatory. Selected synthetic amphipathic peptides derived from the Sta47 antigen sequence identified a 20-amino-acid peptide that gave a 10-fold increase in T-cell proliferation over a control malarial peptide of similar length. Recognition of the 47-kDa antigen by a T-cell line with TH1 characteristics implicates this protein as one of potential importance in protection studies and future vaccine development. C1 WALTER REED ARMY INST RES,DEPT RICKETTSIAL DIS,WASHINGTON,DC 20307. UNIV MARYLAND,DEPT MICROBIOL,COLL PK,MD 20742. OI Stover, Charles/0000-0002-7406-1696 NR 52 TC 17 Z9 21 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 1993 VL 61 IS 5 BP 1674 EP 1681 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA KZ177 UT WOS:A1993KZ17700010 PM 8478055 ER PT J AU WASSERMAN, GM KUMAR, S AHLERS, J RAMSDELL, F BERZOFSKY, JA MILLER, LH AF WASSERMAN, GM KUMAR, S AHLERS, J RAMSDELL, F BERZOFSKY, JA MILLER, LH TI AN APPROACH TO DEVELOPMENT OF SPECIFIC T-LYMPHOCYTE LINES BY USE OF PREPROCESSED ANTIGENS IN PLASMODIUM-VINCKEI-VINCKEI MURINE MALARIA SO INFECTION AND IMMUNITY LA English DT Article ID STIMULATORY FACTOR-I; VACCINE DEVELOPMENT; CELL LINE; MONOCLONAL-ANTIBODY; IMMUNE-RESPONSE; CLONES; IMMUNOSUPPRESSION; PROTECTION; DEFINITION; CHABAUDI AB The development of parasite-specific T-cell lines represents one approach to the potential identification of relevant immunogens in erythrocytic malarial infection. However, the use of parasitized-erythrocyte lysates as antigens inhibits the proliferation of T cells. To circumvent this problem, we preincubated antigen-presenting cells (APCs) from spleens of malaria-naive, BALB/c mice with a Plasmodium vinckei vinckei (hereafter referred to as P. vinckei)-parasitized erythrocyte lysate. APCs were subsequently irradiated and washed prior to being incubated with T lymphocytes from P. vinckei-immune, histocompatible mice. After 8 to 10 cycles of antigenic stimulation and rest, two T-cell lines were analyzed. Both lines were predominantly CD4+. Proliferation assays demonstrated marked lymphocyte blastogenesis to syngeneic but not allogeneic APCs that had preprocessed malarial antigen. Antigen incubated directly with T cells and nonpulsed APCs in vitro did not result in T-cell proliferation. Assays of interleukin-2 (IL-2), IL-4, IL-5, and gamma interferon were compatible with one cell line being predominantly T(H)1 and the other being T(H)2. Thus, APCs that have preprocessed malarial antigen and are free of extraneous parasite material induce highly reactive, antigen-specific, major histocompatibility complex-restricted T-cell lines that functionally appear capable of inducing humoral and/or cell-mediated immunity. C1 NIAID,MALARIA RES LAB,BETHESDA,MD 20892. NIAID,CELLULAR & MOLEC IMMUNOL LAB,BETHESDA,MD 20892. NCI,IMMUNOGENET & VACCINE RES SECT,BETHESDA,MD 20892. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 41 TC 2 Z9 3 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 1993 VL 61 IS 5 BP 1958 EP 1963 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA KZ177 UT WOS:A1993KZ17700049 PM 8478085 ER PT J AU OCKENHOUSE, CF TANDON, NN JAMIESON, GA GREENWALT, DE AF OCKENHOUSE, CF TANDON, NN JAMIESON, GA GREENWALT, DE TI ANTIGENIC AND FUNCTIONAL DIFFERENCES IN ADHESION OF PLASMODIUM-FALCIPARUM-INFECTED ERYTHROCYTES TO HUMAN AND BOVINE CD36 SO INFECTION AND IMMUNITY LA English DT Article ID GLYCOPROTEIN-IV CD36; PLATELET MEMBRANE GLYCOPROTEIN; PAS-IV; PARASITIZED ERYTHROCYTES; MEDIATES CYTOADHERENCE; EPITHELIAL-CELLS; OKM5 ANTIGEN; RECEPTOR; MALARIA; PROTEIN AB Cytoadherence by Plasmodium falciparum-infected erythrocytes (PRBC) to microvascular endothelium is, in part, mediated by the specific interaction between a parasite-derived erythrocyte surface ligand and a specific binding site on human CD36. We describe the selection for increased adhesion of PRBC to bovine CD36 and demonstrate that the molecular interaction between PRBC and bovine CD36 is independent of and distinct from the OKM5/8 monoclonal antibody epitopes which block PRBC-human CD36 binding. C1 AMER RED CROSS,HOLLAND LAB,15601 CRABBS BRANCH WAY,ROCKVILLE,MD 20855. WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. FU NHLBI NIH HHS [HL40858] NR 27 TC 11 Z9 11 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 1993 VL 61 IS 5 BP 2229 EP 2232 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA KZ177 UT WOS:A1993KZ17700089 PM 7683005 ER PT J AU CAPACIO, BR BYERS, CE JACKSON, TK MATTHEWS, RL AF CAPACIO, BR BYERS, CE JACKSON, TK MATTHEWS, RL TI AN HPLC METHOD FOR THE DETERMINATION OF GRANISETRON IN GUINEA-PIG PLASMA SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID ANTAGONIST; GR38032F RP CAPACIO, BR (reprint author), USA,MED RES INST CHEM DEF,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 12 TC 8 Z9 8 U1 0 U2 0 PU PRESTON PUBLICATIONS INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD MAY-JUN PY 1993 VL 17 IS 3 BP 151 EP 155 PG 5 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA LD480 UT WOS:A1993LD48000006 PM 8393119 ER PT J AU BAZE, WB AF BAZE, WB TI SOMAN-INDUCED MORPHOLOGICAL-CHANGES - AN OVERVIEW IN THE NONHUMAN PRIMATE SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE SOMAN; NERVE AGENT; PATHOLOGY; NONHUMAN PRIMATES ID NITRIC-OXIDE; NERVOUS-SYSTEM; NEUROTOXICITY; GLUTAMATE; SARIN; RATS AB A review of the literature was conducted to provide an overview of organophosphorus (OP)-induced morphological changes in the non-human primate. Most studies have evaluated effects of the OP nerve agent soman (pinacolyl methylphosphonofluoridate), an irreversible inhibitor of acetylcholinesterase. Soman-induced acute and chronic morphological changes have been examined. The effects of nerve agent therapy (i.e. pyridostigmine, praloxidime chloride and atropine), with and without an anticonvulsant (i.e. diazepam, midazolam), on soman-induced lesions have also been studied. Acute changes in the central nervous system of rhesus and cynomolgus monkeys exposed to soman alone or soman and therapy, without an anticonvulsant, were characterized by neuronal degeneration and necrosis and neuropil edema. The lesions were usually present in the frontal cortex, entorhinal cortex, amygdaloid complex, caudate nucleus, thalamus and hippocampus. Morphologically, these lesions resemble lesions produced by hypoxic-ischemic injury or by seizures and are similar to soman-induced changes in other laboratory animals. Nerve agent therapy supplemented with an anticonvulsant reduced or prevented soman-induced acute neural lesions. Acute changes in non-neural tissues were limited to the heart (e.g. hemorrhage, myofiber necrosis, myocarditis) and skeletal muscle (e.g. myofiber necrosis). Heart lesions in the non-human primate are similar to OP-induced heart lesions in man. The pathogenesis of the acute lesions in both the central nervous system and heart is discussed. Consistent soman-induced chronic morphological changes have not been produced in the rhesus monkey or baboon. RP BAZE, WB (reprint author), USA,CHEM DEF RES INST,ABERDEEN PROVING GROUND,MD 21010, USA. NR 32 TC 29 Z9 30 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD MAY-JUN PY 1993 VL 13 IS 3 BP 173 EP 177 DI 10.1002/jat.2550130306 PG 5 WC Toxicology SC Toxicology GA LD993 UT WOS:A1993LD99300004 PM 8326086 ER PT J AU WINET, H HOLLINGER, JO AF WINET, H HOLLINGER, JO TI INCORPORATION OF POLYLACTIDE-POLYGLYCOLIDE IN A CORTICAL DEFECT - NEOOSTEOGENESIS IN A BONE CHAMBER SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH LA English DT Article ID BIODEGRADABLE POLYMERS; FIXATION; TISSUE AB One hundred-micron-thick threads of 40-kDa copolymer polylactide:polyglycolide (PLGA) in a 50:50 molar ratio in bone chambers were implanted in rabbit tibias. Weekly intravital microscopic observations were used to assess trabecular ingrowth and PLGA absorption, processes referred to as incorporation. Nineteen rabbits were observed from the 3rd (W3) to the 10th or 12th (W10/W12) week postimplantation. Analysis of digitally processed video images obtained weekly showed that PLGA absorption was completed in about 8-10 weeks and trabecular ingrowth delayed to about 1 week slower than its control value. Four of the bone chambers showed PLGA unraveled by week 3, no trabecular ingrowth, and significantly reduced neovascularization. No such apparent inhibitory effects were observed in bone chambers that displayed PLGA absorption. No causal link could be established between the rate of neoosteogenesis and the rate of PLGA absorption, but it was clear that incorporation slowed and rapid degradation inhibited bone regeneration. It was concluded that copolymer synthesis and postsynthesis processing must result in a synthetic with a predictable micro- and macro-molecular structure before one can predict its incorporability in a given reconstruction or fixation site. C1 UNIV SO CALIF,LOS ANGELES,CA 90007. USA,INST DENT RES,WASHINGTON,DC 20307. RP WINET, H (reprint author), ORTHOPED HOSP,LOS ANGELES,CA 90007, USA. NR 20 TC 44 Z9 44 U1 0 U2 1 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-9304 J9 J BIOMED MATER RES JI J. Biomed. Mater. Res. PD MAY PY 1993 VL 27 IS 5 BP 667 EP 676 DI 10.1002/jbm.820270514 PG 10 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA KX333 UT WOS:A1993KX33300013 PM 7686160 ER PT J AU HULL, AE ACHESON, DWK ECHEVERRIA, P DONOHUEROLFE, A KEUSCH, GT AF HULL, AE ACHESON, DWK ECHEVERRIA, P DONOHUEROLFE, A KEUSCH, GT TI MITOMYCIN IMMUNOBLOT COLONY ASSAY FOR DETECTION OF SHIGA-LIKE TOXIN-PRODUCING ESCHERICHIA-COLI IN FECAL SAMPLES - COMPARISON WITH DNA PROBES SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HEMOLYTIC UREMIC SYNDROMES; HEMORRHAGIC COLITIS; PURIFICATION; DIARRHEA; GENES; HYBRIDIZATION; ANTIBODIES; THAILAND; STRAINS; PHAGE AB We developed a direct screening immunoblot assay for the detection of Shiga-like toxin (SLT)-producing organisms in stool samples. The assay takes advantage of the phage-mediated nature of SLT production in Escherichia coli and the phage-inducing effects of mitomycin. The addition of mitomycin significantly enhanced the amount of toxin available for immunologic detection. By using the mitomycin-enhanced immunoblot assay, SLT-producing E. coli could be distinguished from non-toxin-producing E. coli and normal stool flora in ratios of 1:1,000 to 1:5,000. The immunoblot assay was examined in a field setting and compared with direct DNA probing for SLT-I and SLT-II.The assay was able to detect SLT-producing E. coli with a high level of sensitivity and specificity. Specificity was markedly improved by using a monoclonal antibody which cross-reacts with both SLT-I and SLT-II B subunits in place of the polyclonal antitoxin sera. We conclude that the mitomycin-enhanced immunoblot colony assay is a rapid and reliable alternative to DNA probing for the detection of phage-mediated SLT-producing organisms in stool samples, especially when the production and use of nucleic acid probes are not feasible. In addition, it permits isolation of positive colonies for further study and confirmation. C1 NEW ENGLAND MED CTR,DIV GEOG MED & INFECT DIS,BOSTON,MA 02111. ARMED FORCES RES INST MED SCI,DEPT BACTERIOL,BANGKOK,THAILAND. FU NIAID NIH HHS [AI-20235, AI-16242]; NIDDK NIH HHS [DK-34928] NR 26 TC 48 Z9 48 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 1993 VL 31 IS 5 BP 1167 EP 1172 PG 6 WC Microbiology SC Microbiology GA KY463 UT WOS:A1993KY46300024 PM 8501216 ER PT J AU SUMMERS, PL DUBOIS, DR COHEN, WH MACARTHY, PO BINN, LN SJOGREN, MH SNITBHAN, R INNIS, BL ECKELS, KH AF SUMMERS, PL DUBOIS, DR COHEN, WH MACARTHY, PO BINN, LN SJOGREN, MH SNITBHAN, R INNIS, BL ECKELS, KH TI SOLID-PHASE ANTIBODY CAPTURE HEMADSORPTION ASSAY FOR DETECTION OF HEPATITIS-A VIRUS IMMUNOGLOBULIN-M ANTIBODIES SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HEMAGGLUTINATION INHIBITION ANTIBODIES; IMMUNOSORBENT TECHNIQUE; RADIOIMMUNOASSAY AB A solid-phase antibody capture hemadsorption (SPACH) assay was developed to detect hepatitis A virus (HAV)-specific immunoglobulin M (IgM) antibodies in sera from humans recently infected with hepatitis. The assay is performed with microtiter plates coated with anti-human IgM antibodies to capture IgM antibodies from the test sera. HAV-specific IgM antibody is detected by the addition of HAV hemagglutinating antigen and goose erythrocytes. Hemadsorption of erythrocytes to antigen-antibody complexes attached to the solid phase indicate the presence of IgM antibodies. The SPACH assay was compared to a commercial radioimmunoassay and was found to be equally or more sensitive and specific for the detection of HAV IgM antibodies. The SPACH assay is an alternative, rapid assay that doesn't require hazardous substrates or radioactivity for the detection of HAV-specific antibodies. C1 WALTER REED ARMY INST RES,DEPT BIOL RES & VIRUS DIS,WASHINGTON,DC 20307. USA,INST MED SCI,BANGKOK,THAILAND. NR 12 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 1993 VL 31 IS 5 BP 1299 EP 1302 PG 4 WC Microbiology SC Microbiology GA KY463 UT WOS:A1993KY46300049 PM 8388890 ER PT J AU BURRIS, H IRVIN, R KUHN, J KALTER, S SMITH, L SHAFFER, D FIELDS, S WEISS, G ECKARDT, J RODRIGUEZ, G RINALDI, D WALL, J COOK, G SMITH, S VREELAND, F BAYSSAS, M LEBAIL, N VONHOFF, D AF BURRIS, H IRVIN, R KUHN, J KALTER, S SMITH, L SHAFFER, D FIELDS, S WEISS, G ECKARDT, J RODRIGUEZ, G RINALDI, D WALL, J COOK, G SMITH, S VREELAND, F BAYSSAS, M LEBAIL, N VONHOFF, D TI PHASE-I CLINICAL-TRIAL OF TAXOTERE ADMINISTERED AS EITHER A 2-HOUR OR 6-HOUR INTRAVENOUS-INFUSION SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID TAXOL; RP-56976; ANALOGS C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. RHONE POULENC RORER,COLLEGEVILLE,PA. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP BURRIS, H (reprint author), CANC THERAPY & RES CTR S TEXAS,8122 DATAPOINT DR,CLIN INVEST,SUITE 650,SAN ANTONIO,TX 78229, USA. NR 28 TC 149 Z9 153 U1 2 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY PY 1993 VL 11 IS 5 BP 950 EP 958 PG 9 WC Oncology SC Oncology GA LA026 UT WOS:A1993LA02600022 PM 8098059 ER PT J AU ABBOTT, KC BAKRIS, G AF ABBOTT, KC BAKRIS, G TI RENAL EFFECTS OF ANTIHYPERTENSIVE MEDICATIONS - AN OVERVIEW SO JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article ID CONVERTING ENZYME-INHIBITORS; INSULIN-DEPENDENT DIABETICS; CALCIUM-ANTAGONISTS; BLOOD-PRESSURE; GLOMERULAR HEMODYNAMICS; MILD HYPERTENSION; SODIUM-INTAKE; THERAPY; RAT; NEPHROPATHY AB A variety of antihypertensive agents are available for management of elevated arterial pressure. Although these agents all effectively lower arterial pressure, they have somewhat diverse renal hemodynamic profiles. This report reviews the various similarities and differences in renal hemodynamic profiles among the different antihypertensive agents. C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV NEPHROL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,DEPT MED,DIV NEPHROL,FT SAM HOUSTON,TX 78234. NR 94 TC 8 Z9 9 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0091-2700 J9 J CLIN PHARMACOL JI J. Clin. Pharmacol. PD MAY PY 1993 VL 33 IS 5 BP 392 EP 399 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA LB240 UT WOS:A1993LB24000002 PM 8101193 ER PT J AU LOUSHINE, RJ JURCAK, JJ JEFFALONE, DM AF LOUSHINE, RJ JURCAK, JJ JEFFALONE, DM TI A 2-ROOTED MANDIBULAR INCISOR SO JOURNAL OF ENDODONTICS LA English DT Article AB A case report is presented demonstrating a two-rooted mandibular incisor. Because of prosthetic considerations, endodontic therapy was not performed and the tooth was extracted. However, this case reinforces the importance of proper radiographic techniques and interpretation in detecting radicular anomalies. C1 USA,DENT ACT,FT BENNING,GA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAY PY 1993 VL 19 IS 5 BP 250 EP 251 DI 10.1016/S0099-2399(06)81302-6 PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LA316 UT WOS:A1993LA31600009 PM 8360604 ER PT J AU KAIDOH, T NATH, J OKOYE, V AIKAWA, M AF KAIDOH, T NATH, J OKOYE, V AIKAWA, M TI NOVEL STRUCTURE IN THE PELLICULAR COMPLEX OF PLASMODIUM-FALCIPARUM GAMETOCYTES SO JOURNAL OF EUKARYOTIC MICROBIOLOGY LA English DT Article DE MALARIA; MICROTUBULES; ULTRASTRUCTURE ID HUMAN MALARIA PARASITES; CULTURE AB Using transmission electron microscopy, transverse dense bands were found to be associated with subpellicular microtubules and inner membranes in Plasmodium falciparum gametocytes. These dense bands may act as supportive structures to maintain the parallel arrangement of the microtubules, and/or to connect them to the inner membranes. C1 CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106. WALTER REED ARMY INST RES,DEPT HEMATOL,DIV MED,WASHINGTON,DC 20307. FU NIAID NIH HHS [AI-10645] NR 11 TC 5 Z9 5 U1 0 U2 0 PU SOC PROTOZOOLOGISTS PI LAWRENCE PA 810 E 10TH ST, LAWRENCE, KS 66044 SN 1066-5234 J9 J EUKARYOT MICROBIOL JI J. Eukaryot. Microbiol. PD MAY-JUN PY 1993 VL 40 IS 3 BP 269 EP 271 DI 10.1111/j.1550-7408.1993.tb04916.x PG 3 WC Microbiology SC Microbiology GA LE432 UT WOS:A1993LE43200009 PM 8508166 ER PT J AU VANBROCKLIN, C AF VANBROCKLIN, C TI MILITARY APPLICATIONS OF CHLOROTRIFLUOROETHYLENE OLIGOMER BASE NONFLAMMABLE HYDRAULIC FLUID SO JOURNAL OF FIRE SCIENCES LA English DT Article C1 USA,CTR BELVOIR RES DEV & ENGN,FT BELVOIR,VA 22060. NR 11 TC 0 Z9 0 U1 0 U2 0 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0734-9041 J9 J FIRE SCI JI J. Fire Sci. PD MAY-JUN PY 1993 VL 11 IS 3 BP 232 EP 241 DI 10.1177/073490419301100303 PG 10 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA KX942 UT WOS:A1993KX94200003 ER PT J AU FINNERTY, AE POLYANSKI, S AF FINNERTY, AE POLYANSKI, S TI USING POWDER PACKS FOR PASSIVE FIRE PROTECTION OF MILITARY VEHICLES SO JOURNAL OF FIRE SCIENCES LA English DT Article C1 USA,COMBAT SYST TEST ACTIV,STECS-LI-V,ABERDEEN PROVING GROUND,MD 21005. RP FINNERTY, AE (reprint author), USA,BALLIST RES LAB,SLCBR-TB-EE,ABERDEEN PROVING GROUND,MD 21005, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0734-9041 J9 J FIRE SCI JI J. Fire Sci. PD MAY-JUN PY 1993 VL 11 IS 3 BP 242 EP 254 DI 10.1177/073490419301100304 PG 13 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA KX942 UT WOS:A1993KX94200004 ER PT J AU ENK, AH ANGELONI, VL UDEY, MC KATZ, SI AF ENK, AH ANGELONI, VL UDEY, MC KATZ, SI TI AN ESSENTIAL ROLE FOR LANGERHANS CELL-DERIVED IL-1-BETA IN THE INITIATION OF PRIMARY IMMUNE-RESPONSES IN SKIN SO JOURNAL OF IMMUNOLOGY LA English DT Article ID ANTIGEN-PRESENTING CELLS; INVIVO; SENSITIZATION; INTERLEUKIN-1; GENERATION; EXPRESSION; INDUCTION AB Langerlians cells (LC) are Ag-presenting cells required for induction of primary immune responses in skin. After activation by Ag, LC express increased levels of MHC class II Ag, exhibit increased accessory cell activity, and migrate to regional lymph nodes where they stimulate T cells. One of the earliest manifestations of LC activation is the accumulation of increased amounts of IL-1 beta mRNA in LC within 15 min after exposure to contact allergens in vivo. To determine if enhanced IL-1beta production by LC could be causally linked to epicutaneous sensitization, we injected IL-1beta intradermally into the ears of BALB/c mice and extracted total epidermal RNA 4 h later. A quantitative reverse transcriptase-polymerase chain reaction technique was used to compare changes in IL-1alpha, IL-1beta, macrophage inflammatory protein 2, IL-10, TNF-alpha, and I-Aalpha chain mRNA signals caused by intradermally-injected IL-1beta to those caused by intradermal IL-1alpha or TNFalpha, or by topical application of the contact allergen trinitrochlorobenzene (3% TNCB). Intradermal injection of 25 ng IL-1beta resulted in 5-to 100-fold enhancement of mRNA signals for IL-1alpha, IL-1beta, MIP-2, IL-10, TNFalpha, and class II I-Aalpha, mimicking the changes caused by allergen. In contrast, injection of equivalent amounts of IL-1alpha or TNFalpha did not significantly alter the epidermal cytokine pattern. Simulating the effects of topically applied TNCB, intradermally-injected IL-1beta (but not IL-1alpha or TNFalpha) also caused enhancement of LC MHC class II expression. In addition, LC derived from IL-1beta-injected skin were 2 to 3 times more potent accessory cells in an anti-CD3 proliferation assay than LC from IL-1alpha or sham-injected skin. Finally, injection of hamster anti-mIL-1beta mAb into the skin prior to TNCB treatment completely prevented sensitization to this allergen, although injections of similar amounts of hamster anti-mlL-1alpha mAb or PBS were without effect. Taken together, our data indicate that dendritic cell-derived IL-1beta may be a critical molecule required for initiation of primary immune responses in skin. C1 NCI,DERMATOL BRANCH,BLDG 10,ROOM 12N 238,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DERMATOL CLIN,WASHINGTON,DC 20307. NR 20 TC 346 Z9 351 U1 0 U2 3 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 1993 VL 150 IS 9 BP 3698 EP 3704 PG 7 WC Immunology SC Immunology GA KY452 UT WOS:A1993KY45200004 PM 8473727 ER PT J AU FRIEDLANDER, AM WELKOS, SL PITT, MLM EZZELL, JW WORSHAM, PL ROSE, KJ IVINS, BE LOWE, JR HOWE, GB MIKESELL, P LAWRENCE, WB AF FRIEDLANDER, AM WELKOS, SL PITT, MLM EZZELL, JW WORSHAM, PL ROSE, KJ IVINS, BE LOWE, JR HOWE, GB MIKESELL, P LAWRENCE, WB TI POSTEXPOSURE PROPHYLAXIS AGAINST EXPERIMENTAL INHALATION ANTHRAX SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note AB Inhalation anthrax is a rare disease that is almost invariably fatal. This study determined whether a prolonged course of postexposure antibiotics with or without vaccination would protect monkeys exposed to a lethal aerosol dose of Bacillus anthracis when the antibiotic was discontinued. Beginning 1 day after exposure, groups of 10 animals were given penicillin, ciprofloxacin, doxycycline, doxycycline plus vaccination, vaccination alone, or saline. Antibiotics were administered for 30 days and then discontinued. Vaccine was given on days 1 and 15. Two animals died of causes other than anthrax and were not included in the statistical analysis. Nine of 10 controls and 8 of 10 animals given only vaccine died. Each antibiotic regimen completely protected animals while on therapy and provided significant long-term protection upon discontinuance of the drug (penicillin, 7 of 10 survived, P < .02; ciprofloxacin, 8 of 9 survived, P < .002; doxycycline, 9 of 10 survived, P < .002; doxycycline plus vaccination, 9 of 9 survived, P < .0002). Protection against rechallenge was provided by combining postexposure antibiotic treatment with vaccination. RP FRIEDLANDER, AM (reprint author), USA,MED RES INST INFECT DIS,DIV BACTERIOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 15 TC 249 Z9 253 U1 2 U2 8 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY PY 1993 VL 167 IS 5 BP 1239 EP 1243 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA KZ499 UT WOS:A1993KZ49900043 PM 8486963 ER PT J AU COLEMAN, RE ROBERT, LL ROBERTS, LW GLASS, JA SEELEY, DC LAUGHINGHOUSE, A PERKINS, PV WIRTZ, RA AF COLEMAN, RE ROBERT, LL ROBERTS, LW GLASS, JA SEELEY, DC LAUGHINGHOUSE, A PERKINS, PV WIRTZ, RA TI LABORATORY EVALUATION OF REPELLENTS AGAINST 4 ANOPHELINE MOSQUITOS (DIPTERA, CULICIDAE) AND 2 PHLEBOTOMINE SAND FLIES (DIPTERA, PSYCHODIDAE) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE REPELLENTS; DEET; PIPERIDINES ID TESTS AB Deet, the lactone CIC-4, and the piperidine compounds A13-37220 and A13-35765 were evaluated for initial repellency against laboratory-reared Anopheles albimanus Wiedemann, An. freeborni Aitken, An. gambiae Giles, An. stephensi Liston, and Phlebotomus papatasi (Scopoli) using a dose-response testing procedure on human volunteers. In addition, deet and CIC-4 were tested against Lutzomyia longipalpis (Lutz & Neiva). In general, the repellency of A13-37220, A13-35765, and CIC-4 was not markedly different from that of deet against each species tested; however, the different species varied greatly in response to the repellents. Overall, An. stephensi, L. longipalpis, and P. papatasi were the most sensitive, and An. albimanus the most tolerant species. The four repellents subsequently were tested against An. stephensi and An. albimanus to determine the duration of repellency. AI3-37220 provided effective (>90%) protection against An. stephensi bites for 7 h, whereas deet, A13-35765, and CIC-4 provided 6, 5, and 3 h of protection, respectively. Each of the four compounds provided < 1 h of protection against An. albimanus bites. RP COLEMAN, RE (reprint author), WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 15 TC 34 Z9 39 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1993 VL 30 IS 3 BP 499 EP 502 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA LA702 UT WOS:A1993LA70200001 PM 8510108 ER PT J AU DURDEN, LA TURELL, MJ AF DURDEN, LA TURELL, MJ TI INEFFICIENT MECHANICAL TRANSMISSION OF LANGAT (TICK-BORNE ENCEPHALITIS-VIRUS COMPLEX) VIRUS BY BLOOD-FEEDING MITES (ACARI) TO LABORATORY MICE SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Note DE LANGAT VIRUS; VECTOR COMPETENCE; MITES AB One day after feeding on a viremic mouse, tropical rat mites, Ornithonyssus bacoti (Hirst), transmitted Langat (tick-borne encephalitis virus complex) virus to a naive suckling mouse in one of four trials. However, no transmissions to naive mice by 0. bacoti were recorded either immediately after the viremic blood meal (0/4 trials) or on days 4-18 (0/20 trials). After feeding on a viremic mouse, chicken mites, Dermanyssus gallinae (De Geer), failed to transmit Langat virus to naive suckling mice in any trials (0/24). Although virus failed to replicate in either species of mite, it was detectable in 20% (2/10) of 0. bacoti individuals 1 d after a viremic blood meal, but only immediately after the viremic blood meal in 20% (2/10) of D. gallinae mites. Neither mite appears to be an efficient vector of Langat virus. C1 USA,MED RES INST INFECT DIS,DIV APPL RES,FREDERICK,MD 21702. NR 11 TC 7 Z9 7 U1 1 U2 1 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1993 VL 30 IS 3 BP 639 EP 641 PG 3 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA LA702 UT WOS:A1993LA70200025 PM 8389878 ER PT J AU JACOB, E CIERNY, G FALLON, MT MCNEILL, JF SIDERYS, GS AF JACOB, E CIERNY, G FALLON, MT MCNEILL, JF SIDERYS, GS TI EVALUATION OF BIODEGRADABLE CEFAZOLIN SODIUM MICROSPHERES FOR THE PREVENTION OF INFECTION IN RABBITS WITH EXPERIMENTAL OPEN TIBIAL FRACTURES STABILIZED WITH INTERNAL-FIXATION SO JOURNAL OF ORTHOPAEDIC RESEARCH LA English DT Article ID BEADS AB Immediate internal fixation of severe open tibial fractures usually is contraindicated due to the high risk of infection. The objective of this study was to evaluate the efficacy of local antibiotic therapy with biodegradable poly-(DL-lactide-co-glycolide) cefazolin-loaded microspheres for the prevention of infection in experimental open fractures stabilized with internal fixation. Rabbits with experimental tibial fractures that were contaminated with Staphylococcus aureus were treated with local application of cefazolin microspheres, an equivalent local dose of free Ancef powder, or systemic Ancef therapy. The bones then were fixed with a four-hole plate, and the animals were observed for 8 weeks. Clinically, deep infection was present in 86% of control animals that received no antibiotics and in 60% of animals that received a 7 day course of systemic Ancef therapy. In contrast, no infections were noted among any of the surviving rabbits that received local therapy with either cefazolin microspheres or free Ancef powder. Significantly higher levels of serum cefazolin were measured at 1 h for animals treated with free Ancef powder (18.7 +/- 6.1 mug/ml) than for those treated with cefazolin microspheres (0.57 +/- 0.27 mug/ml). Follow-up studies are in progress to evaluate further the potential clinical benefits of local antibiotic therapy for the management of contaminated open fractures in humans. C1 ATLANTA VET ADM MED CTR,ATLANTA,GA. EMORY UNIV,SCH MED,DEPT ORTHOPED,ATLANTA,GA 30322. EMORY UNIV,SCH MED,DEPT PATHOL & LAB MED,ATLANTA,GA 30322. RP JACOB, E (reprint author), US ARMY INST DENT RES,WALTER REED ARMY MED CTR,MICROBIOL BRANCH,BLDG 40,WASHINGTON,DC 20307, USA. NR 29 TC 22 Z9 22 U1 0 U2 0 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 SN 0736-0266 J9 J ORTHOPAED RES JI J. Orthop. Res. PD MAY PY 1993 VL 11 IS 3 BP 404 EP 411 DI 10.1002/jor.1100110312 PG 8 WC Orthopedics SC Orthopedics GA LJ210 UT WOS:A1993LJ21000011 PM 8326446 ER PT J AU BURROWS, WD NELSON, JH AF BURROWS, WD NELSON, JH TI IV FLUIDMAKERS - PREPARATION OF STERILE WATER FOR INJECTION IN A FIELD SETTING SO JOURNAL OF PARENTERAL SCIENCE AND TECHNOLOGY LA English DT Article AB Two approaches have been investigated for generating USP sterile, pyrogen-free water for injection (WFI) from potable water in the field. The first approach utilizes reverse osmosis (RO), ion exchange, a solid matrix filter containing activated carbon and zeta adsorbent, a final 0.2 mum pore size sterilizing filter and a device for transferring the WFI to an IV bag; prototype systems based on three different hand-operated RO units weigh 1.5-3.5 kg and are capable of producing WFI at rates of 1-10 L/hr. Parenteral solutions were made by adding WFI to an IV bag containing concentrated Ringer's lactate. The second approach, still in the breadboard stage, is similar but utilizes a larger ion exchange column in place of the RO unit and a multiport distribution head to fill a set of 18 1-L IV bags. This system, considered to be disposable, is capable of generating water of WFI quality at a fill rate of 0.5 L/min from a pressurized source. RP BURROWS, WD (reprint author), USA,BIOMED RES & DEV LAB,FT DETRICK,FREDERICK,MD 21702, USA. NR 14 TC 0 Z9 0 U1 1 U2 3 PU PARENTERAL DRUG ASSOC, INC PI BETHESDA PA 7500 OLD GEORGETOWN RD, STE, 620, BETHESDA, MD 20814 SN 0279-7976 J9 J PARENT SCI TECHN PD MAY-JUN PY 1993 VL 47 IS 3 BP 124 EP 129 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA LX960 UT WOS:A1993LX96000004 PM 8360804 ER PT J AU PICHOFF, BE UYEHARA, CFT NAKAMURA, KT AF PICHOFF, BE UYEHARA, CFT NAKAMURA, KT TI EFFECT OF CALCIUM AGONISTS, BAY-K-8644 AND CGP-28392, ON GUINEA-PIG AIRWAY SMOOTH-MUSCLE FUNCTION DURING DEVELOPMENT SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID BAY K-8644; CONTRACTILE RESPONSES; RAT AORTA; DIHYDROPYRIDINE; TRACHEAL; TISSUES; RESPONSIVENESS; SENSITIVITY; ANTAGONISTS; REACTIVITY AB Dihydropyridine calcium agonists affect airway smooth muscle function by modulating the voltage-dependent calcium channel. Two such agonists, BAY K 8644 and CGP 28392 increase airway smooth muscle tone in adult guinea pigs but their actions during ontogeny are unknown. We compared contractile responses of airway tissue from fetal, newborn and young adult guinea pigs to cumulative doses of both BAY K 8644 and CGP 28392 under isometric conditions in vitro. Responses were examined in the presence and absence of aspirin to determine if endogenous cyclooxygenase products modulated these effects. BAY K 8644 generated a contractile response in 85 of 86 tissues. Maximum contraction was greater in extrathoracic tracheas from newborns when compared to adults (P < .05). In fetuses and newborns, contraction overall was greater in the presence of aspirin; however, in adult airways cyclooxygenase blockade did not appear to have any effect (P < .05). In contrast, CGP 28392 produced no contraction in 14 of 19 tracheas (all ages combined) in the presence of aspirin; whereas, all 18 tracheas in the absence of aspirin contracted. Also, there were no significant differences in maximum response among these age groups or tissue types to CGP 28392. Increased sensitivity of tracheas in immature guinea pigs was observed for both drugs in the absence of aspirin. Our results demonstrate: 1) BAY K 8644 appears to produce greater maximal contractions; 2) BAY K 8644 shows differences in airway smooth muscle contraction with respect to age of guinea pig, tracheobronchial segment used and whether aspirin was present or not; 3) CGP 28392, while producing airway smooth muscle contraction in the absence of exogenous contractile agents, is almost completely without contractile activity in the presence of aspirin; and 4) fetal and newborn extrathoracic trachea in the absence of aspirin are more sensitive to BAY K 8644 and CGP 28392 than young adults. C1 KAPIOLANI MED CTR WOMEN & CHILDREN,DEPT PEDIAT,1319 PUNAHOU ST,HONOLULU,HI 96826. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. JOHN A BURNS SCH MED,HONOLULU,HI. FU NHLBI NIH HHS [HL-45220] NR 31 TC 3 Z9 3 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD MAY PY 1993 VL 265 IS 2 BP 524 EP 528 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA LD060 UT WOS:A1993LD06000006 PM 7684444 ER PT J AU LITTMAN, AB FAVA, M HALPERIN, P LAMONFAVA, S DREWS, FR OLESHANSKY, MA BIELENDA, CC MACLAUGHLIN, RA AF LITTMAN, AB FAVA, M HALPERIN, P LAMONFAVA, S DREWS, FR OLESHANSKY, MA BIELENDA, CC MACLAUGHLIN, RA TI PHYSIOLOGICAL BENEFITS OF A STRESS REDUCTION PROGRAM FOR HEALTHY MIDDLE-AGED ARMY OFFICERS SO JOURNAL OF PSYCHOSOMATIC RESEARCH LA English DT Article ID CORONARY-ARTERY DISEASE; ISCHEMIC-HEART-DISEASE; A BEHAVIOR PATTERN; DEHYDROEPIANDROSTERONE SULFATE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; PLASMA-LIPIDS; FOLLOW-UP; MEN; RISK AB Stress reduction programs (SRPs) can reduce morbidity and mortality in patients with coronary artery disease (CAD), This study evaluated the effect of an SRP on metabolic and hormonal risk factors for CAD. Twenty army officers participating in an SRP, Group I, and a comparison group of seventeen SRP nonparticipants, Group C, volunteered to undergo measurement of dehydroepiandrosterone-sulfate (DHEA-S), cortisol, DHEA-S/cortisol ratio, testosterone, apolipoprotein-A1, apolipoprotein-B, triglycerides, cholesterol, fibrinogen, and leukocyte count both before and after the SRP period. No differences in the changes in biochemical risk factors for CAD were found between participant and nonparticipant except for DHEA-S. While Group C had a marked reduction in DHEA-S levels, Group I had a small increase. Previous studies indicate DHEA-S is inversely associated with extent of CAD and age-adjusted DHEA-S levels below 3.78 mumol/l confer an increased risk for CAD mortality. SRP participation appears to effect DHEA-S levels, possibly partially accounting for the benefits observed in SRPs among CAD patients. C1 TUFTS UNIV, USDA, HUMAN NUTR CTR AGING, LIPID METAB LAB, MEDFORD, MA 02155 USA. USA, WAR COLL, CARLISLE, PA 17013 USA. MASSACHUSETTS GEN HOSP, ENDOCRINE STEROID LAB, BOSTON, MA 02114 USA. WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. RP LITTMAN, AB (reprint author), MASSACHUSETTS GEN HOSP, CTR CARDIOVASC HLTH, BEHAV MED CLIN, DEPT PSYCHIAT, DIV BEHAV MED, BOSTON, MA 02114 USA. NR 49 TC 15 Z9 15 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3999 EI 1879-1360 J9 J PSYCHOSOM RES JI J. Psychosomat. Res. PD MAY PY 1993 VL 37 IS 4 BP 345 EP 354 DI 10.1016/0022-3999(93)90136-4 PG 10 WC Psychiatry SC Psychiatry GA LB664 UT WOS:A1993LB66400004 PM 8510060 ER PT J AU SCHULTZ, SR BARRY, RX FORBES, WA JOHNSON, MK AF SCHULTZ, SR BARRY, RX FORBES, WA JOHNSON, MK TI EFFICACY OF FENBENDAZOLE AGAINST GASTROINTESTINAL NEMATODES IN WHITE-TAILED DEER SO JOURNAL OF RANGE MANAGEMENT LA English DT Article DE ANTHELMINTIC; DISEASE; LOUISIANA; ODOCOILEUS-VIRGINIANUS; PARASITES ID ODOCOILEUS-VIRGINIANUS; FASCIOLOIDES-MAGNA; PARASITE CONTROL AB We provided fenbendazole to captive (N = 77) and free-ranging (3 study areas) white-tailed deer (Odocoileus virginianus) in Louisiana to determine effects on gastrointestinal nematode burdens. Fenbendazole reduced gastrointestinal nematode burdens of captive and free-ranging white-tailed deer. Mean eggs per gram of feces from captive deer decreased P<0.01 and P<0.01, respectively) 89% and 84% after provision of fenbendazole in doses approximating 0.47 and 0.62 g/deer, respectively. Doses approximating 0.42-0.46 g/deer did not affect (P = 0.61) eggs per gram of feces collected from free-ranging deer. Mean eggs per gram of feces collected from free-ranging deer was affected by fenbendazole treatment (P = 0.04) and decreased an average of 86% (SE = 1.9) on the 3 study areas after provision of fenbendazole in doses approximating 1.67-1.82 g/deer. Eggs per gram of feces collected from the distal colon and abomasal parasite counts from abomasa of free-ranging deer harvested on the study areas were associated positively (r = 0.706, P<0.001), were affected by fenbendazole treatment (P<0.01 and P<0.01, respectively), and decreased 66% (SE = 5.1) and 52% (SE = 7.4), respectively, after provision of fenbendazole in doses approximating 1.67-1.82 g/deer. A reduction in the crosstransmission of gastrointestinal parasites common to deer and livestock might be possible through fenbendazole treatment of deer. C1 USA CORPS ENGINEERS,CELMK PDQ,VICKSBURG DIST OFF,VICKSBURG,MS 39180. RP SCHULTZ, SR (reprint author), LOUISIANA STATE UNIV,CTR AGR,SCH FORESTRY WILDLIFE & FISHERIES,BATON ROUGE,LA 70803, USA. NR 40 TC 5 Z9 5 U1 1 U2 4 PU SOC RANGE MANAGEMENT PI DENVER PA 1839 YORK ST, DENVER, CO 80206 SN 0022-409X J9 J RANGE MANAGE JI J. Range Manage. PD MAY PY 1993 VL 46 IS 3 BP 240 EP 244 DI 10.2307/4002614 PG 5 WC Agriculture, Dairy & Animal Science; Ecology SC Agriculture; Environmental Sciences & Ecology GA LB229 UT WOS:A1993LB22900009 ER PT J AU LETTERIE, GS MARKENSON, GR MARKENSON, MM AF LETTERIE, GS MARKENSON, GR MARKENSON, MM TI DISCHARGE AGAINST MEDICAL ADVICE IN AN OBSTETRIC UNIT SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article ID FETAL AB Obstetricians have increasingly petitioned courts for orders sanctioning treatment refused by pregnant patients. To speculate on the potential role of forced detention, we reviewed the clinical records of 39 obstetric patients who were discharged against medical advice (AMA) with several diagnoses: preterm labor (27), medical complications of pregnancy (9) and trauma (3). These patients were matched for chronologic age, gestational age and clinical examination at the time of admission and compared to a group of compliant patients who accepted and natal the treatment plan for hospitalization. No perinatal morbidity and/or mortality or other adverse outcome could be documented in the AMA group despite their refusal to continue undergoing admission and therapy. No difference could be demonstrated between the AMA group and the compliant group for obstetric complications, gestational age at delivery, newborn weight and percentage of appropriate-weight-for-gestational-age infants. These data suggest that failure to comply with major obstetric recommendations and hospitalization in these clinical settings might not adversely influence perinatal outcome. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859. NR 12 TC 5 Z9 5 U1 1 U2 2 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA P.O. DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 SN 0024-7758 J9 J REPROD MED JI J. Reprod. Med. PD MAY PY 1993 VL 38 IS 5 BP 370 EP 374 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA LD065 UT WOS:A1993LD06500007 PM 8320674 ER PT J AU DAVALOS, JF KISH, DA WOLCOTT, MP AF DAVALOS, JF KISH, DA WOLCOTT, MP TI BENDING STIFFNESS OF STRESS-LAMINATED TIMBER DECKS WITH BUTT JOINTS SO JOURNAL OF STRUCTURAL ENGINEERING-ASCE LA English DT Note AB Stress-laminated timber bridge decks consist of lumber assemblies transversely posttensioned with high-strength steel bars. The lumber components contain end-to-end butt joints to span the length of the bridge. At any cross section of the bridge, the joints are placed in a regular pattern, with one butt joint in a group of three to five laminae. The presence of butt joints in a bridge deck reduces its longitudinal bending stiffness. Since stress-laminated timber bridge decks are modeled as orthotropic plates, the actual system stiffness properties are needed in the analysis. This paper presents an analytical-experimental study to verify existing bending stiffness reduction factors for decks with regular butt-joint patterns. Forty northern red oak and hickory stress-laminated beams with three butt joint patterns and subjected to three transverse stress levels are tested in bending, and the experimental responses are correlated with existing theoretical predictions using linear regression analysis. Design recommendations are presented. C1 USA,CORPS ENGRS,DES BRANCH,HUNTINGTON,WV 25701. W VIRGINIA UNIV,COLL AGR & FORESTRY,CTR CONSTR FAC,DIV FORESTRY,MORGANTOWN,WV 26506. RP DAVALOS, JF (reprint author), W VIRGINIA UNIV,COLL ENGN,CTR CONSTR FAC,MORGANTOWN,WV 26506, USA. NR 11 TC 6 Z9 7 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9445 J9 J STRUCT ENG-ASCE JI J. Struct. Eng.-ASCE PD MAY PY 1993 VL 119 IS 5 BP 1670 EP 1676 DI 10.1061/(ASCE)0733-9445(1993)119:5(1670) PG 7 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA KY573 UT WOS:A1993KY57300022 ER PT J AU BONACUSE, PJ KALLURI, S AF BONACUSE, PJ KALLURI, S TI AXIAL-TORSIONAL FATIGUE - A STUDY OF TUBULAR SPECIMEN THICKNESS EFFECTS SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE FATIGUE; MULTIAXIAL; IN-PHASE; OUT-OF-PHASE; TUBULAR SPECIMEN; STAINLESS STEEL AB A room-temperature experimental program was conducted on AISI type 316 stainless steel to determine the effect of wall thickness on the cyclic deformation behavior and fatigue life of thin-wall, tubular, axial-torsional fatigue specimens. The following experimental variables were examined in this study: the depth of the surface work-hardened layer produced in specimen machining, and the effects of strain range and axial-torsional strain phasing. Tubular fatigue specimens were fabricated with wall thicknesses of 1.5, 2.0, and 2.5 mm. One as-fabricated specimen from each wall thickness was sectioned for microstructural examination and microhardness measurement. A specimen of each wall thickness was tested at each of three conditions-high strain range in-phase, low strain range in-phase, and low strain range out-of-phase-for a total of nine axial-torsional fatigue experiments. Little or no variation in the fatigue life or deformation behavior as a function of wall thickness was observed. The machining-induced work-hardened zone, as a percentage of the gage section material, was found to have a minimal effect on both deformation behavior and fatigue life. Out-of-phase fatigue tests displayed shorter fatigue lives and more cyclic hardening than in-phase tests. C1 NASA LEWIS RES CTR GRP,SVERDRUP TECHNOL INC,CLEVELAND,OH 44135. RP BONACUSE, PJ (reprint author), NASA,LEWIS RES CTR,USA,RES LAB,VEHICLE PROPULS DIRECTORATE,CLEVELAND,OH 44135, USA. NR 6 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0090-3973 J9 J TEST EVAL JI J. Test. Eval. PD MAY PY 1993 VL 21 IS 3 BP 160 EP 167 PG 8 WC Materials Science, Characterization & Testing SC Materials Science GA KY283 UT WOS:A1993KY28300003 ER PT J AU PATTERSON, JH HAMERNIK, RP HARGETT, CE AHROON, WA AF PATTERSON, JH HAMERNIK, RP HARGETT, CE AHROON, WA TI AN ISOHAZARD FUNCTION FOR IMPULSE NOISE SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID THRESHOLD SHIFTS; PEAK PRESSURE; HAZARD; CHINCHILLA; EXPOSURE; EAR AB Existing criteria for safe exposure to impulse noise do not consider the frequency spectrum of an impulse as a variable in the evaluation of the hazards to the auditory system. This study was designed to determine the relative potential that impulsive energy concentrated at different frequencies has in causing auditory system trauma. One hundred and thirty (130) chinchillas, divided into 22 groups of 5 to 7 animals, were used. Pre- and postexposure audiograms were measured on each animal using avoidance conditioning procedures. Quantitative histology was used to determine the extent and pattern of the sensory cell damage (cochleograms). Noise exposure employed seven different computer-generated narrow-band impulses (approximately 400-Hz bandwidth) having center frequencies located at 0.260, 0.775, 1.025, 1.350, 2.075, 2.450, and 3.550 kHz, presented at two to four different intensities. An isohazard weighting function derived from the audiometric and histological data demonstrates that equivalent amounts of impulsive energy concentrated at different frequencies are not equally hazardous to the auditory system. Comparison of the derived weighting function with the A-weighting curve indicates that low-frequency impulses are less hazardous than predicted by A-weighted sound exposure level. C1 SUNY PLATTSBURG,AUDITORY RES LAB,PLATTSBURGH,NY 12901. RP PATTERSON, JH (reprint author), USA,AEROMED RES LAB,FT RUCKER,AL 36362, USA. NR 34 TC 6 Z9 6 U1 2 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAY PY 1993 VL 93 IS 5 BP 2860 EP 2869 DI 10.1121/1.405805 PG 10 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA LC572 UT WOS:A1993LC57200042 ER PT J AU SPERLING, LC HEIMER, WL AF SPERLING, LC HEIMER, WL TI ANDROGEN BIOLOGY AS A BASIS FOR THE DIAGNOSIS AND TREATMENT OF ANDROGENIC DISORDERS IN WOMEN .1. SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Review ID POLYCYSTIC-OVARY-SYNDROME; HORMONE-BINDING GLOBULIN; CONGENITAL ADRENAL-HYPERPLASIA; 17-KETOSTEROID REDUCTASE DEFICIENCY; STEROID 21-HYDROXYLASE DEFICIENCY; HUMAN GRANULOSA-CELLS; CORD-STROMAL TUMORS; LATE-ONSET; HIRSUTE WOMEN; ANDROSTANEDIOL GLUCURONIDE AB Disorders of androgen excess in women are common in the practice of dermatology. The literature regarding the evaluation and treatment of women with cutaneous hyperandrogenism (acne, hirsutism, and alopecia) is vast and is contained in numerous subspecialty journals. At first glance, the basic science knowledge required to understand androgen biology appears exceedingly complex. However, an understanding of androgen physiology and a familiarity with the relevant literature are the basis of appropriate evaluations and treatment recommendations. In the first of this two-part series, we review the basic science of androgen biology and pathophysiology in women. The second part of this series will cover the evaluation of suspected hyperandrogenic women and the therapeutic modalities that are available. RP SPERLING, LC (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 146 TC 26 Z9 27 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAY PY 1993 VL 28 IS 5 BP 669 EP 683 PN 1 PG 15 WC Dermatology SC Dermatology GA LA303 UT WOS:A1993LA30300001 PM 8496411 ER PT J AU SKELTON, HG SMITH, KJ JOHNSON, FB COOPER, CR TYLER, WF LUPTON, GP AF SKELTON, HG SMITH, KJ JOHNSON, FB COOPER, CR TYLER, WF LUPTON, GP TI ZIRCONIUM GRANULOMA RESULTING FROM AN ALUMINUM ZIRCONIUM COMPLEX - A PREVIOUSLY UNRECOGNIZED AGENT IN THE DEVELOPMENT OF HYPERSENSITIVITY GRANULOMAS SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article AB Zirconium compounds have been associated with the development of hypersensitivity granulomas. However, aluminum zirconium complexes have not previously been shown to induce sensitization. We present the clinical and histologic findings of a case in which a patient developed an acute hypersensitivity reaction to an aluminum zirconium complex. C1 ARMED FORCES INST PATHOL,DEPT CHEM BIOL,WASHINGTON,DC 20306. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. GEORGE WASHINGTON UNIV,SCH MED,WASHINGTON,DC 20052. IRWIN ARMY COMMUNITY HOSP,DEPT PATHOL,FT RILEY,KS. RP SKELTON, HG (reprint author), ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306, USA. NR 16 TC 28 Z9 28 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAY PY 1993 VL 28 IS 5 BP 874 EP 876 DI 10.1016/0190-9622(93)70122-A PN 2 PG 3 WC Dermatology SC Dermatology GA LA304 UT WOS:A1993LA30400015 PM 8491884 ER PT J AU GONG, R LINDBERG, J ABRAMS, J WHITAKER, WR WADE, CE GOUGE, S AF GONG, R LINDBERG, J ABRAMS, J WHITAKER, WR WADE, CE GOUGE, S TI COMPARISON OF HYPERTONIC SALINE SOLUTIONS AND DEXTRAN IN DIALYSIS-INDUCED HYPOTENSION SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article DE HYPOTENSION; DEXTRAN; HEMODIALYSIS; HYPERTONIC ID HEMODIALYSIS; INSTABILITY; NACL AB The efficacy of three hypertonic saline solutions for treating dialysis-induced hypotension in a randomized, blinded, crossover clinical trial of 10 patients (a minimum of three cycles per solution) was compared. Dialysis-induced hypotension, defined as a decrease in systolic blood pressure of at least 10 mm Hg or systolic blood pressure less than 100 mm Hg, was treated with an iv bolus of either 10 mL of 23% saturated hypertonic saline, 30 mL of 7.5% hypertonic saline, or 30 mL of 7.5% saline with 6% dextran 70, each containing similar osmolar loads of 80, 80, and 100 mosM, respectively. All three solutions raised systolic blood pressure within 5 min (mean pretreatment systolic blood pressure, 87 mm Hg; mean posttreatment systolic blood pressure, 101 mm Hg; P< 0.05). The magnitude of the increase was greater with saturated hypertonic saline (15 mm Hg) and dextran 70 (17 mm Hg) compared with that with hypertonic saline (9 mm Hg; P < 0.05). At 10 min, dialysis-induced hypotension was less frequent with saturated hypertonic saline (incidence, 9%) compared with hypertonic saline (45%). Beyond 10 min, however, there was a trend toward a lower incidence of further dialysis-induced hypotension with dextran 70. There were no side effects. Given equal osmole loads, the more concentrated solution produced a greater increase in systolic blood pressure. The addition of an oncotic agent such as dextran may prolong the blood pressure response beyond 10 min. It was concluded that hypertonic saline solutions safely and effectively treat dialysis-induced hypotension. C1 ALTON OCHSNER MED FDN & OCHSNER CLIN,DEPT NEPHROL,1514 JEFFERSON HIGHWAY,NEW ORLEANS,LA 70121. LETTERMAN ARMY MED CTR,SAN FRANCISCO,CA 94129. ALTON OCHSNER MED FDN & OCHSNER CLIN,NEW ORLEANS,LA 70121. WILLIAM BEAUMONT ARMY MED CTR,EL PASO,TX 79920. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NASA,AMES RES CTR,DEPT LIFE SCI,MOFFETT FIELD,CA 94035. BROOK ARMY MED CTR,FT SAM HOUSTON,TX. NR 14 TC 13 Z9 13 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD MAY PY 1993 VL 3 IS 11 BP 1808 EP 1812 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA LF381 UT WOS:A1993LF38100010 PM 7687157 ER PT J AU RUE, LW CIOFFI, WG MCMANUS, WF PRUITT, BA PHILLIPS, LG MEYER, AA TOMPKINS, RG SAFFLE, JR AF RUE, LW CIOFFI, WG MCMANUS, WF PRUITT, BA PHILLIPS, LG MEYER, AA TOMPKINS, RG SAFFLE, JR TI WOUND CLOSURE AND OUTCOME IN EXTENSIVELY BURNED PATIENTS TREATED WITH CULTURED AUTOLOGOUS KERATINOCYTES SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 52ND ANNUAL SESSION OF THE AMERICAN ASSOC FOR THE SURGERY OF TRAUMA CY SEP 17-19, 1992 CL LOUISVILLE, KY SP AMER ASSOC SURG TRAUMA ID EXPERIENCE; EPITHELIUM; EPIDERMIS; SUBSTRATE; COLLAGEN; SKIN AB Cultured autologous keratinocytes (CAK) have been heralded as a means to achieve more rapid closure of massive burn wounds. Despite the claimed benefits of this technology, we have failed to identify its positive impact on wound closure in extensively burned patients. Sixteen patients with a mean age of 29.7 years (range, 10-56 years) and a mean total body surface area burn of 68.2% (range, 42%-85%) underwent 22 applications of CAK supplied by a private laboratory. The keratinocyte grafts were applied to a mean of 15.9% of the body surface area (range, 4%-59%) at an average cost per patient of $43,705 (range, $9,800 to $161,000). The mean body surface area of definitive wound coverage by these grafts was 4.7% (range, 0%-18.6%). The mean length of hospitalization was 132 days (range, 50-275 days). The observed mortality was 12.5% (two patients). Our experience with this wound care approach has been assessed with respect to the extent of burn, the level of wound excision, and the site of CAK application. RP RUE, LW (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 14 TC 101 Z9 102 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 1993 VL 34 IS 5 BP 662 EP 668 DI 10.1097/00005373-199305000-00008 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA LG403 UT WOS:A1993LG40300008 PM 8497000 ER PT J AU DIXON, TK RITCHEY, ML BOYKIN, W HARPER, B ZEIDMAN, E THOMPSON, IM AF DIXON, TK RITCHEY, ML BOYKIN, W HARPER, B ZEIDMAN, E THOMPSON, IM TI TRANSPARENCHYMAL SUTURE FIXATION AND TESTICULAR HISTOLOGY IN A PREPUBERTAL RAT MODEL SO JOURNAL OF UROLOGY LA English DT Article DE TESTIS; RATS, INBRED STRAINS; SUTURE TECHNIQUES; HISTOLOGY ID ORCHIOPEXY; CRYPTORCHIDISM; TESTIS AB We evaluate the effect on testicular histology when fine suture materials are used for transparenchymal suture fixation of the testis during orchiopexy in immature Sprague-Dawley rats. Significant inflammatory reactions were observed in all groups of animals with suture fixation regardless of suture size and material. Only 5% of the animals in the dartos pouch control group had an inflammatory response and no inflammation was noted in the nonoperative controls. Although these findings have not been documented in humans, this evidence raises concerns about the impact of surgical technique on the future reproductive capabilities of these testes. Alternatives to transparenchymal suture fixation of the testis should be considered in patients with cryptorchidism and testicular torsion. Sutureless dartos pouch placement may provide adequate fixation during most orchiopexies without risking injury to testicular structure and function. C1 UNIV MICHIGAN,UROL SECT,ANN ARBOR,MI 48109. RP DIXON, TK (reprint author), BROOKE ARMY MED CTR,DEPT SURG,UROL RES LABS,FT SAM HOUSTON,TX 78234, USA. NR 13 TC 18 Z9 18 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAY PY 1993 VL 149 IS 5 BP 1116 EP 1118 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA LA464 UT WOS:A1993LA46400045 PM 8097792 ER PT J AU ARMSTRONG, LE CURTIS, WC HUBBARD, RW FRANCESCONI, RP MOORE, R ASKEW, EW AF ARMSTRONG, LE CURTIS, WC HUBBARD, RW FRANCESCONI, RP MOORE, R ASKEW, EW TI SYMPTOMATIC HYPONATREMIA DURING PROLONGED EXERCISE IN HEAT SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE SODIUM; FLUID-ELECTROLYTE BALANCE; ALDOSTERONE; RENIN; ARGININE VASOPRESSIN; PLASMA VOLUME; HYPERHYDRATION ID WATER-INTOXICATION; MARATHON; FLUID; COMPLICATION; ELECTROLYTE AB Although hyponatremia (HN) has been reported among endurance athletes, its etiology often remains uncertain and of great interest to clinicians and physiologists. This case report presents physiologic evidence regarding the etiology and development of HN during exercise in the heat. A 21-yr-old male volunteer (K.G.) unexpectedly experienced symptomatic HN during a research investigation that involved controlled sodium (Na+) intake (137 mEq Na+.d-1 for 7d) and exercise-heat acclimation 1-degrees-C; 30 min.h-1,8 h.d-1 for 10 d). Fluid balance, physiologic variables, and hematologic/hormone data were measured before and after the HN episode, with similar measurements recorded for nine unaffected volunteers. The results indicated: 1) HN was verified in K.G. (plasma Na+ < 130 mEq.l-1) after only 4 h of mild, intermittent exercise in heat; 2) K.G.'s heart rate, rectal temperature, blood pressure, and Na+ losses in sweat and urine were less-than-or-equal-to control subjects at all times; 3) between hours 4-7, an inappropriately large release of vasopressin coincided with a decrease of urine volume to 0 ml.h-1. It was concluded that a large intake (10.3 l.7h-1) and retention (2.77 l.7h-1) of water and a ''low normal'' initial plasma Na+ (134 mEq.l-1) were primary factors in the development of HN in K.G., whereas Na+ losses in sweat and urine were normal and served only to exacerbate HN. C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. RP ARMSTRONG, LE (reprint author), UNIV CONNECTICUT,HUMAN PERFORMANCE LAB,BOX U-110,2095 HILLSIDE RD,STORRS,CT 06269, USA. NR 25 TC 61 Z9 61 U1 0 U2 5 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 1993 VL 25 IS 5 BP 543 EP 549 PG 7 WC Sport Sciences SC Sport Sciences GA LA333 UT WOS:A1993LA33300002 PM 8492680 ER PT J AU VANDRE, RH KLEBERS, J TESCHE, FM BLANCHARD, JP AF VANDRE, RH KLEBERS, J TESCHE, FM BLANCHARD, JP TI ELECTROMAGNETIC PULSE (EMP) .2. FIELD-EXPEDIENT WAYS TO MINIMIZE ITS EFFECTS ON FIELD MEDICAL-TREATMENT FACILITIES SO MILITARY MEDICINE LA English DT Article AB Part I of this paper showed that a field commander can expect approximately 65% of his unprotected electronic medical equipment to be damaged by the electromagnetic pulse (EMP) from a single nuclear detonation as far as 2200 km away. Using computer modeling, field-expedient ways to minimize the effects of EMP were studied. The results were: (1) keep wiring near the ground, (2) keep wiring short, (3) unplug unused equipment, (4) run power cabling and tents in a magnetic north-south direction (avoid running power cabling in the east-west direction), and (5) place sensitive equipment in International Organization for Standardization shelters. RP VANDRE, RH (reprint author), WALTER REED ARMY MED CTR,INST DENT RES,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1993 VL 158 IS 5 BP 285 EP 289 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA LB249 UT WOS:A1993LB24900005 PM 8502388 ER PT J AU JENNINGS, BM AF JENNINGS, BM TI PATIENT-CARE OUTCOMES - IMPLICATIONS FOR THE MILITARY HEALTH-SERVICES SYSTEM SO MILITARY MEDICINE LA English DT Article AB Policy makers are targeting patient outcomes and the effectiveness of interventions as possible ways to curb spiraling health care costs. Quality assurance/improvement programs are focusing on patient outcomes as a way to evaluate and improve care delivery. Consequently, members of the Military Health Services System need a solid understanding of the current emphasis on the outcomes of care to be knowledgeable participants in the health care changes precipitated by highlighting patient outcomes. RP JENNINGS, BM (reprint author), USA,HLTH PROFESSIONALS SUPPORT AGCY,DIV CLIN POLICY,WASHINGTON,DC 20310, USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1993 VL 158 IS 5 BP 289 EP 294 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA LB249 UT WOS:A1993LB24900006 PM 8502389 ER PT J AU GARLAND, FN AF GARLAND, FN TI COMBAT STRESS-CONTROL IN THE POSTWAR THEATER - MENTAL-HEALTH CONSULTATION DURING THE REDEPLOYMENT PHASE OF OPERATION-DESERT-STORM SO MILITARY MEDICINE LA English DT Article AB The redeployment phase of Operation Desert Storm resulted in a number of clinical and casualty management challenges to the mental health support system. Psychological factors affecting post-combat adjustment may be unique to this short, successful operation. Evacuation policy and available assets will be discussed in light of their effects on clinical presentations, and recommendations made for combat psychiatric policy in future foreign interventions. RP GARLAND, FN (reprint author), EISENHOWER ARMY MED CTR,PSYCHOL SERV,FT GORDON,GA 30905, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1993 VL 158 IS 5 BP 334 EP 338 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA LB249 UT WOS:A1993LB24900016 PM 8502398 ER PT J AU GAFFNEY, CL PARRY, WH AF GAFFNEY, CL PARRY, WH TI PERMISSION GRANTED SO MILITARY MEDICINE LA English DT Letter RP GAFFNEY, CL (reprint author), USA,USAHSC,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1993 VL 158 IS 5 BP A5 EP A5 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA LB249 UT WOS:A1993LB24900002 PM 8502387 ER PT J AU SATIN, AJ SEIKEN, GL CUNNINGHAM, FG AF SATIN, AJ SEIKEN, GL CUNNINGHAM, FG TI REVERSIBLE HYPERTENSION IN PREGNANCY CAUSED BY OBSTRUCTIVE UROPATHY SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID ACUTE-RENAL-FAILURE; URETERAL OBSTRUCTION; GRAVID UTERUS; SECONDARY; RENIN AB Background: Hypertension with deterioration of renal function after mid-pregnancy often signifies preeclampsia and the need for delivery. Cases: We have encountered three women with reversible hypertension related to obstructive uropathy. The women presented between 21-30 weeks' gestation with hypertension accompanied by significantly increased serum creatinine. Although pregnancy-induced hypertension was considered initially in all, there was no other evidence of preeclampsia. In all three, ureteral obstruction was confirmed radiographically and found to be associated with uterine overdistention or congenital urinary anomalies. Relief of obstruction by ureteral stent placement or percutaneous nephrostomy was followed by diuresis and resolution of hypertension. In all three women, pregnancy was extended by more than 6 weeks. Conclusion: Urinary obstruction is a rare but potentially reversible cause of hypertension in pregnancy. Relief of obstruction may lead to normalization of blood pressure and negate the need for immediate delivery. C1 BROOKE ARMY MED CTR,DEPT MED,DIV NEPHROL,SAN ANTONIO,TX. UNIV TEXAS,SW MED CTR,DEPT OBSTET & GYNECOL,DALLAS,TX 75230. NR 11 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD MAY PY 1993 VL 81 IS 5 BP 823 EP 825 PN 2 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA KY491 UT WOS:A1993KY49100009 PM 8469485 ER PT J AU ARTENSTEIN, AW EISEMAN, AS CAMPBELL, GC AF ARTENSTEIN, AW EISEMAN, AS CAMPBELL, GC TI CHRONIC DACRYOCYSTITIS CAUSED BY MYCOBACTERIUM-FORTUITUM SO OPHTHALMOLOGY LA English DT Article AB Purpose: To characterize the clinical presentation of Myobacterium fortuitum dacryocystitis, an unusual microbial cause of this disease. Methods: The authors present a detailed description of a case of M. fortuitum chronic dacryocystitis and a review of the literature. Findings: Although M. fortuitum is a well-recognized cause of chronic keratitis and corneal ulcer, it has only been reported once previously as a cause of dacryocystitis. Multiple factors that alter the ocular environment of the host may predispose to infection with this organism. The diagnosis requires isolation of the organism in the appropriate clinical setting. The authors' case represents the first patient successfully treated with dacryocystectomy. Conclusion: M. fortuitum is a rare cause of chronic dacryocystitis that may respond favorably to surgical therapy alone. C1 WALTER REED ARMY MED CTR,OPHTHALMOL SERV,WASHINGTON,DC 20307. RP ARTENSTEIN, AW (reprint author), WALTER REED ARMY MED CTR,DEPT MED,INFECT DIS SERV,WASHINGTON,DC 20307, USA. NR 9 TC 11 Z9 11 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0161-6420 J9 OPHTHALMOLOGY JI Ophthalmology PD MAY PY 1993 VL 100 IS 5 BP 666 EP 668 PG 3 WC Ophthalmology SC Ophthalmology GA LB970 UT WOS:A1993LB97000019 PM 8493008 ER PT J AU HARDEN, CS SNYDER, AP EICEMAN, GA AF HARDEN, CS SNYDER, AP EICEMAN, GA TI DETERMINATION OF COLLISION-INDUCED DISSOCIATION MECHANISMS AND CROSS-SECTIONS IN ORGANOPHOSPHORUS COMPOUNDS BY ATMOSPHERIC-PRESSURE IONIZATION TANDEM MASS-SPECTROMETRY SO ORGANIC MASS SPECTROMETRY LA English DT Article ID FRAGMENTATION MECHANISMS; TRIPLE QUADRUPOLES; DIMETHYL; IONS; INSTRUMENT; PHOSPHITE; H2O AB Nineteen organophosphorus compounds (OPCs) of the generic classes (dialkyl alkyl'-phosphonates (twelve compounds) and tri-alkyl phosphates (seven compounds) were investigated by atmospheric pressure ionization (API) tandem mass spectrometry (MS/MS). All OPCs showed consistent and comparable collision-induced dissociation (CID) pathways allowing for a generalized scheme for dissociation. When the alkyl groups are equal to or larger than ethyl, CID mechanisms are dominated by McLafferty rearrangements and neutral losses are stable molecules in all cases except cleavage of P-C or O-C bonds to form alkyl fragment ions. CID cross-sections for the OPCs were determined with excellent reproducibility and a good correlation was found with a simple model. Inferences with respect to ionic structures were made from observed trends in the cross-section measurements. Limitations in API-MS/MS instruments of this design are found in the energy distribution of the ionization and ion sampling events. C1 NEW MEXICO STATE UNIV,DEPT CHEM,LAS CRUCES,NM 88003. RP HARDEN, CS (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,RES & TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 25 TC 27 Z9 27 U1 0 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0030-493X J9 ORG MASS SPECTROM JI Org. Mass Spectrom. PD MAY PY 1993 VL 28 IS 5 BP 585 EP 592 DI 10.1002/oms.1210280520 PG 8 WC Chemistry, Organic; Spectroscopy SC Chemistry; Spectroscopy GA LD163 UT WOS:A1993LD16300019 ER PT J AU SCHUSTER, BG MIHOUS, WK AF SCHUSTER, BG MIHOUS, WK TI REDUCED RESOURCES APPLIED TO ANTIMALARIAL DRUG DEVELOPMENT SO PARASITOLOGY TODAY LA English DT Review ID PLASMODIUM-FALCIPARUM; ANTIMALARIAL-DRUGS; RESISTANCE; CHLOROQUINE AB This statement was made in 1984 (Ref I): The Agency for International Development (AID) announced a major breakthrough in the development of a vaccine against the most deadly form of malaria in human beings. The vaccine should be ready for use around the world, especially in developing countries, within five years. Since then, the spending on development of drugs against malaria has been on the decline. Brian Schuster and Wilbur Milhous wonder did we declare victory too soon? Wouldn't the prudent approach have been to look ot vaccines and drugs as complementary techniques rather than alternative approaches? RP SCHUSTER, BG (reprint author), WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 14 TC 13 Z9 13 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0169-4758 J9 PARASITOL TODAY JI Parasitol. Today PD MAY PY 1993 VL 9 IS 5 BP 167 EP 168 DI 10.1016/0169-4758(93)90139-7 PG 2 WC Parasitology SC Parasitology GA KZ009 UT WOS:A1993KZ00900006 PM 15463745 ER PT J AU RASZKA, WV SKILLMAN, LP MCEVOY, PL AF RASZKA, WV SKILLMAN, LP MCEVOY, PL TI POTENTIAL ROLE OF TRIMETHOPRIM-SULFAMETHOXAZOLE IN THE TREATMENT OF PEDIATRIC MYCOBACTERIUM-AVIUM COMPLEX INFECTIONS SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Letter DE TRIMETHOPRIM-SULFAMETHOXAZOLE; MYCOBACTERIUM-AVIUM COMPLEX INFECTIONS C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. RP RASZKA, WV (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307, USA. NR 7 TC 3 Z9 3 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD MAY PY 1993 VL 12 IS 5 BP 418 EP 419 DI 10.1097/00006454-199305000-00020 PG 2 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA LC782 UT WOS:A1993LC78200020 PM 8327308 ER PT J AU BEHRMANN, G BOWEN, J AF BEHRMANN, G BOWEN, J TI A HYBRID APPROACH OPENS DOORS FOR DIFFRACTIVE OPTICS SO PHOTONICS SPECTRA LA English DT Article RP BEHRMANN, G (reprint author), USA,RES LAB,OPT PROC TECHNOL BRANCH,WASHINGTON,DC 20310, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LAURIN PUBL CO INC PI PITTSFIELD PA BERKSHIRE COMMON PO BOX 1146, PITTSFIELD, MA 01202 SN 0731-1230 J9 PHOTON SPECTRA JI Photon. Spect. PD MAY PY 1993 VL 27 IS 5 BP 159 EP & PG 0 WC Optics SC Optics GA LB553 UT WOS:A1993LB55300027 ER PT J AU WASSERMAN, EA YUEN, DA RUSTAD, JR AF WASSERMAN, EA YUEN, DA RUSTAD, JR TI COMPOSITIONAL EFFECTS ON THE TRANSPORT AND THERMODYNAMIC PROPERTIES OF MGO-SIO2 MIXTURES USING MOLECULAR-DYNAMICS SO PHYSICS OF THE EARTH AND PLANETARY INTERIORS LA English DT Article ID COMPUTER-SIMULATION; SHEAR VISCOSITY; HIGH-PRESSURE; SILICATES; GLASS; SIO2; COEFFICIENTS; DIFFUSION; EQUATION; BOUNDARY AB We have carried out equilibrium molecular dynamics simulations of MgO-SiO2 mixtures with compositions continuously ranging from 20 to 80 mol.% MgO using Born-Mayer-type pairwise interaction potentials. Enthalpies of mixing, self-diffusion and mutual diffusion coefficients, shear viscosities, radial distribution functions and infrared absorption spectra were calculated. Self-diffusion coefficients determined at various pressures and temperatures ranging from 3500 to 5000 K increase significantly with greater amounts of MgO. The compositional increase of the mutual diffusion coefficient is less pronounced. The calculated compositional dependence of shear viscosity differs significantly from that expected from Stokes-Einstein or Eyring relationships. Computed radial distribution functions, velocity autocorrelation functions, and infrared absorption spectra allow for the monitoring of changes in melt structure with varying composition. C1 UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,ARMY HIGH PERFORMANCE COMP RES CTR,1200 WASHINGTON AVE S,MINNEAPOLIS,MN 55415. UNIV MINNESOTA,DEPT GEOL & GEOPHYS,MINNEAPOLIS,MN 55415. NR 41 TC 12 Z9 12 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0031-9201 J9 PHYS EARTH PLANET IN JI Phys. Earth Planet. Inter. PD MAY PY 1993 VL 77 IS 3-4 BP 189 EP 203 DI 10.1016/0031-9201(93)90098-T PG 15 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA LF885 UT WOS:A1993LF88500005 ER PT J AU GRABAU, JH AF GRABAU, JH TI ANIMAL ISSUES AND SOCIETY SO TOXICOLOGY LETTERS LA English DT Article; Proceedings Paper CT CONF ON APPLICATIONS OF ADVANCES IN TOXICOLOGY TO RISK ASSESSMENT CY MAY 19-21, 1992 CL WRIGHT PATTERSON AFB, OH SP ARMSTRONG LAB, OCCUPAT & ENVIRONM HLTH DIRECTORATE, TOXICOL DIV, USN, NAVAL MED RES INST DETACHMENT, USA, BIOMED RES & DEV LAB DE ANIMAL RIGHTS; ANIMAL WELFARE; ANIMAL USE; ANIMAL ISSUES; ANIMAL PATENTS; ANIMAL ACTIVISTS; ANIMAL RESEARCH AB Animal use topics are sensitive issues today. Animal uses issues are often presented as black and white or 'we' are right and 'they' are wrong. This is clearly demonstrated in the available literature from most organizations. Topics presented will include: delineation of issues and concerned groups; examples of animal issues in education and agriculture; the terrorist issue; examples of animal issues/sportsman issues; examples of political and legislative impact; and examples of biomedical and toxicology animal use issues. RP GRABAU, JH (reprint author), USA,ARMSTRONG LAB,ARMY MED RES UNIT,WRIGHT PATTERSON AFB,OH 45433, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD MAY PY 1993 VL 68 IS 1-2 BP 51 EP 57 DI 10.1016/0378-4274(93)90118-H PG 7 WC Toxicology SC Toxicology GA LH577 UT WOS:A1993LH57700009 PM 8516774 ER PT J AU CALDWELL, DJ AF CALDWELL, DJ TI USE OF ALTERNATIVE END-POINTS WITH THE UPITT-II METHOD FOR ASSESSING THE TOXICITY OF SMOKE SO TOXICOLOGY LETTERS LA English DT Article; Proceedings Paper CT CONF ON APPLICATIONS OF ADVANCES IN TOXICOLOGY TO RISK ASSESSMENT CY MAY 19-21, 1992 CL WRIGHT PATTERSON AFB, OH SP ARMSTRONG LAB, OCCUPAT & ENVIRONM HLTH DIRECTORATE, TOXICOL DIV, USN, NAVAL MED RES INST DETACHMENT, USA, BIOMED RES & DEV LAB DE UPITT-II METHOD; COMBUSTION TOXICOLOGY; SMOKE TOXICITY; ALTERNATIVE END POINTS ID HYDROGEN-CYANIDE; CARBON-MONOXIDE; THERMAL-DECOMPOSITION; POTENTIAL TOXICITY; BURNING POLYMERS; DOUGLAS-FIR; LOW OXYGEN; ATMOSPHERES; GASES; PERFORMANCE AB A small-scale combustion module and animal exposure system for evaluating flaming combustion and toxicity of smoke from burning polymers has been developed at the University of Pittsburgh and designated the UPitt II method [1]. It is a radical departure from previous attempts to evaluate toxicity of smoke from burning polymers and represents a significant improvement over previous systems because well-defined burning conditions can be established over a wide range of imposed heat flux and ventilation levels, not possible to examine with previous methods. Thus, smoke toxicity can be evaluated under a range of burning conditions and differences in toxic potency and time to effect can be evaluated [2]. A potential smoke hazard (PSH) index was developed which integrates the material performance characteristics which determine ease of ignition of a polymer with toxic potency, time to death, and rate of generation of toxicants [3]. This paper describes sublethal endpoints that can be used with the UPitt II method and modifications to the PSH index for evaluating the toxicity of smoke generated by burning polymers. RP CALDWELL, DJ (reprint author), USA,BIOMED RES & DEV LAB,OCCUPAT HLTH RES DETACHMENT,WRIGHT PATTERSON AFB,OH 45433, USA. NR 27 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD MAY PY 1993 VL 68 IS 1-2 BP 241 EP 249 DI 10.1016/0378-4274(93)90135-K PG 9 WC Toxicology SC Toxicology GA LH577 UT WOS:A1993LH57700026 PM 8516769 ER PT J AU CHANG, FCT BENTON, BJ LENZ, RA CAPACIO, BR AF CHANG, FCT BENTON, BJ LENZ, RA CAPACIO, BR TI CENTRAL AND PERIPHERAL CARDIORESPIRATORY EFFECTS OF SAXITOXIN (STX) IN URETHANE-ANESTHETIZED GUINEA-PIGS SO TOXICON LA English DT Article ID FOCAL COLD BLOCK; EXPIRATORY NEURONS; BOTZINGER COMPLEX; MEDULLA; TETRODOTOXIN; CAT; PROJECTIONS; INHIBITION; NUCLEUS; REGION AB Effects of saxitoxin (STX; 10 mug/kg; i.p.) on cardio-respiratory activities were evaluated in urethane-anesthetized guinea-pigs. Concurrent recordings were made of electrocorticogram (ECoG), bulbar respiratory-related unit activities, diaphragmatic electromyogram (DEMG), electrocardiogram (Lead II ECG), blood pressure, heart rate, end-tidal CO2, arterial O2/CO2 tensions, and arterial pH. The average time to STX-induced respiratory failure was about 10 min. The most striking effect prior to apnea was a state of progressive bradypnea which emerged 5-7 min after the toxin administration. Other noteworthy responses included (i) a time-dependent decrease in ECoG amplitudes which typically began before the development of a bradypneic profile; (ii) an increasing degree of diaphragm neuromuscular blockade; (iii) a state of combined hypercapnia and uncompensated acidemia; (iv) a declining blood pressure; (v) an incrementally dysfunctional myocardial performance; and (vi) an increasingly degenerative central respiratory activity profile which ultimately culminated in a complete loss of central respiratory drive. The therapeutic effect of intratracheally administered oxygen was equivocal in that the cardio-respiratory activities, be they of central of peripheral nature, remained conspicuously dysfunctional and precarious despite 100% oxygen ventilation. What can be inferred from this study is two-fold. First, STX-induced ventilatory insufficiency can be attributed to a loss of functional integrity of both central and peripheral respiratory system components. That is, although diaphragm blockade contributes significantly to STX-induced respiratory failure, analyses of single respiratory unit activity data revealed that the central respiratory rhythmogenic mechanism also appeared to play a pivotal role in the development of a bradypneic profile which promotes, and directly causes, a complete loss of respiratory drive. Second, a state of unabating depression of central respiratory activities, which seemed to be refractory to the effect of O2, suggests STX has a direct and persistent action on medullary rhythmogenic mechanisms. In conclusion, these findings indicate that both central and peripheral cardio-respiratory components are critically involved in STX-induced apnea, dysfunctional cardiovascular performance, and lethality. RP CHANG, FCT (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 48 TC 13 Z9 15 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD MAY PY 1993 VL 31 IS 5 BP 645 EP 664 DI 10.1016/0041-0101(93)90119-4 PG 20 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA LB894 UT WOS:A1993LB89400010 PM 8332995 ER PT J AU HOFFMAN, KJ GAYDOS, JC KRIEG, RE DUNCAN, JF MACARTHY, PO TICEHURST, JR JARAMILLO, R REYES, LG SJOGREN, MH LEGTERS, LJ AF HOFFMAN, KJ GAYDOS, JC KRIEG, RE DUNCAN, JF MACARTHY, PO TICEHURST, JR JARAMILLO, R REYES, LG SJOGREN, MH LEGTERS, LJ TI INITIAL REPORT OF A HEPATITIS INVESTIGATION IN RURAL BELIZE SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VIRUS-INFECTION; PREVALENCE AB In spring 1991, Belizian health officials expressed concern about a possible hepatitis outbreak in a banana farming district. A study was designed to identify cases and to address the serological prevalence of hepatitis virus markers. Three populations were studied: (i) persons meeting a clinical case definition for hepatitis; (ii) designated banana workers; and (iii) people in a random sample of households in the community. Information was collected using questionnaires and sera were collected for laboratory testing. This report presents the preliminary results of a study conducted in June 1991. Among people who met the clinical case definition, 24% of 42 tested had immunoglobulin M antibody to hepatitis B virus (HBV) core antigen (anti-HBc IgM). In the worker and household survey populations, 284 and 280 people, respectively, were tested for anti-HBc IgM. In each group, 4% were positive. HBV surface antigen was found in 37% of 43 clinical cases, 18% of workers, and 13% of people in the household survey. Among the 3 study populations, the prevalence of HBV core antibody (anti-HBc) ranged from 73% to 81%. Almost all tested persons had evidence of prior hepatitis A virus infection. Evidence of prior infection with hepatitis viruses A and B was widespread, but an aetiology could not be established for most of the clinical cases. However, the prevalence of hepatitis B markers in this population was very high compared to other reports from the Caribbean. C1 BELIZE UNITED STATES EPIDEMIOL RES CTR,BELIZE CITY,BELIZE. WALTER REED ARMY INST RES,DEPT VIRAL DIS,WASHINGTON,DC 20307. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP HOFFMAN, KJ (reprint author), UNIFORMED SERV UNIV HLTH SCI,SCH MED,DEPT PREVENT MED & BIOMETR,BETHESDA,MD 20814, USA. RI Ticehurst, John/I-7532-2012 NR 13 TC 5 Z9 5 U1 0 U2 1 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD MAY-JUN PY 1993 VL 87 IS 3 BP 259 EP 262 DI 10.1016/0035-9203(93)90117-9 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LL995 UT WOS:A1993LL99500008 PM 8236384 ER PT J AU NASIDI, A MONATH, TP VANDENBERG, J TOMORI, O CALISHER, CH HURTGEN, X MUNUBE, GRR SORUNGBE, AOO OKAFOR, GC WALI, S AF NASIDI, A MONATH, TP VANDENBERG, J TOMORI, O CALISHER, CH HURTGEN, X MUNUBE, GRR SORUNGBE, AOO OKAFOR, GC WALI, S TI YELLOW-FEVER VACCINATION AND PREGNANCY - A 4-YEAR PROSPECTIVE-STUDY SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SERUM; VIRUS AB During an outbreak of yellow fever (YF) in Nigeria in 1986-1987, women at various stages of pregnancy were vaccinated against YF, either because those pregnancies were not known at the time or because they requested vaccination out of fear of acquiring the disease. This offered an opportunity to assess the safety and efficacy of YF vaccine in pregnant women and the effect of this vaccine on their newborn children. Pre-vaccination and post-vaccination serum samples from the vaccinated pregnant women were tested by enzyme-linked immunosorbent assay and by neutralization tests for antibody to YF virus. The results showed that the antibody responses of these pregnant women were much lower than those of YF-vaccinated, non-pregnant women in a comparable control group. Follow-up of these women and their newborn children for 3-4 years showed no abnormal effect that could be attributed to the YF vaccine, which suggests that vaccination of pregnant women, particularly during a YF epidemic, may not be contraindicated. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. BETHESDA MISSIONARY HOSP,OJU LOCAL GOVT AREA,BENUE STATE,NIGERIA. UNIV IBADAN,DEPT VIROL,IBADAN,NIGERIA. CTR DIS CONTROL,NATL CTR INFECT DIS,DIV VECTOR BORNE INFECT DIS,FT COLLINS,CO 80522. MED SANS FRONTIERES,AMSTERDAM,NETHERLANDS. WHO,LAGOS,NIGERIA. FED MINIST HLTH,DEPT PRIMARY HEALTHCARE,LAGOS,NIGERIA. UNIV NIGERIA,TEACHING HOSP,ENUGU,NIGERIA. UNIV LAGOS,HOSP TEACHING,LAGOS,NIGERIA. RP NASIDI, A (reprint author), FED VACCINE PROD LAB,PMB 2010,LAGOS,NIGERIA. NR 13 TC 49 Z9 51 U1 0 U2 4 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD MAY-JUN PY 1993 VL 87 IS 3 BP 337 EP 339 DI 10.1016/0035-9203(93)90156-K PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LL995 UT WOS:A1993LL99500036 PM 8236412 ER PT J AU HEWETSON, JF RIVERA, VR CREASIA, DA LEMLEY, PV RIPPY, MK POLI, MA AF HEWETSON, JF RIVERA, VR CREASIA, DA LEMLEY, PV RIPPY, MK POLI, MA TI PROTECTION OF MICE FROM INHALED RICIN BY VACCINATION WITH RICIN OR BY PASSIVE TREATMENT WITH HETEROLOGOUS ANTIBODY SO VACCINE LA English DT Article DE RICIN; INHALATION; PROTECTION; ANTIBODY; VACCINATION ID TOXICITY; ENTRY; ABRIN AB Mice were vaccinated subcutaneously with 25 mug kg-1 of ricin in the presence of Freund's complete adjuvant or Ribi(TM) adjuvant, followed by a boost 14 days later with 50 mug kg-1 ricin in Freund's incomplete adjuvant or Ribi adjuvant, respectively. Three subsequent boosts at 28-day intervals with 25 mug kg-1 ricin yielded high anti-ricin antibody titres as determined by ELISA. Vaccinated animals were exposed to an aerosolized LD99 dose of ricin. With the exception of one death not attributable to ricin intoxication, all vaccinated mice survived the lethal aerosol exposure. In addition, a passive protection regimen was evaluated in mice pretreated with 100 mug purified goat anti-ricin IgG administered intravenously, and then challenged with ricin intravenously. All were resistant to 125 mug kg-1 of ricin, a dose greater than 25 times the intravenous lethal dose. Mice injected intravenously with 5 mg of the same IgG were protected from a lethal aerosol challenge. These results indicated that it is possible to protect animals from inhaled ricin by vaccination or passive administration of specific antibodies. C1 USA,DIV PATHOL,FREDERICK,MD 21702. RP HEWETSON, JF (reprint author), USA,DIV TOXINOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 19 TC 37 Z9 39 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD MAY PY 1993 VL 11 IS 7 BP 743 EP 746 DI 10.1016/0264-410X(93)90259-Z PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA LD249 UT WOS:A1993LD24900009 PM 8342322 ER PT J AU HAO, OJ PHULL, KK DAVIS, AP CHEN, JM MALONEY, SW AF HAO, OJ PHULL, KK DAVIS, AP CHEN, JM MALONEY, SW TI WET AIR OXIDATION OF TRINITROTOLUENE MANUFACTURING RED WATER SO WATER ENVIRONMENT RESEARCH LA English DT Article DE DINITROTOLUENE SULFONATES; 1,3-DINITROBENZENE; NITROBENZENE; NITROSOMONAS; RED WATER; TRINITROTOLUENE; WET AIR OXIDATION ID TOXICITY AB An effective use of the wet air oxidation (WAO) process at a temperature of 340-degrees-C and 0.8 MPa P(O2(25-degrees-C)) to treat diluted trinitrotoluene (TNT) red water was previously demonstrated. This study presents the results of a 1-hour WAO of red water at temperatures ranging from 200-degrees to 320-degrees-C, and P(O2) from 0.13 to 1.31 MPa, in terms of contaminant reduction and intermediate appearance. Also, comparison is made between the toxicity of the raw and the WAO-treated red water on two biological systems. Results show the WAO removal efficiency to be a function primarily of temperature and, to a lesser extent, of P(O2). Acetic acid and 1,3-dinitrobenzene (DNB) accumulated at lower temperatures. For example, total organic carbon (TOC) and chemical oxygen demand (COD) removals at 260-degrees-C and 0.62 MPa P(O2) were 77 and 91%, respectively. Acetic acid and DNB concentrations were 60 and 21 mg/L, respectively. At 320-degrees-C and 0.62 MPa, however, the acetic acid and DNB levels were 38 and 6 mg/L, respectively. The corresponding TOC and COD reductions were 94 and 99%. Organic products formed during the WAO of red water appear to be responsible for adverse effects on nitrite production rates of enriched, unacclimated Nitrosomonas, as compared with raw red water. The WAO-treated water, however, had no effect on the heterotrophic activated sludge capability in degrading glucose. C1 USA,CORPS ENGINEERS,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL. RP HAO, OJ (reprint author), UNIV MARYLAND,DEPT CIVIL ENGN,ENVIRONM ENGN PROGRAM,COLL PK,MD 20742, USA. RI DAVIS, ALLEN/F-1066-2017 OI DAVIS, ALLEN/0000-0001-7818-1890 NR 20 TC 22 Z9 26 U1 1 U2 3 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 SN 1061-4303 J9 WATER ENVIRON RES JI Water Environ. Res. PD MAY-JUN PY 1993 VL 65 IS 3 BP 213 EP 220 PG 8 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA LK982 UT WOS:A1993LK98200004 ER PT J AU VLACHOS, DG SCHMIDT, LD ARIS, R AF VLACHOS, DG SCHMIDT, LD ARIS, R TI COMPARISON OF SMALL METAL-CLUSTERS - NI, PD, PT, CU, AG, AU SO ZEITSCHRIFT FUR PHYSIK D-ATOMS MOLECULES AND CLUSTERS LA English DT Article; Proceedings Paper CT 6TH INTERNATIONAL SYMP ON SMALL PARTICLES AND INORGANIC CLUSTERS ( ISSCIP 6 ) CY SEP 16-22, 1992 CL CHICAGO, IL SP NATL SCI FDN, NATO, ARGONNE NATL LAB, UNIV CHICAGO, CHEM DEPT, DOW, FORD MOTOR, IBM, THREE M CO, AMOCO, EXXON ID LENNARD-JONES CLUSTERS; EMBEDDED-ATOM-METHOD; ENERGETICS; SURFACES; DYNAMICS; NICKEL AB Structures of small clusters of Ni, Pd, Pt, Cu, Ag, and Au with n=2-34 and n=55 atoms are calculated as functions of number of atoms and temperature by the simulated annealing Monte Carlo method using an embedded atom potential. C1 UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RP VLACHOS, DG (reprint author), UNIV MINNESOTA,DEPT CHEM ENGN & MAT SCI,MINNEAPOLIS,MN 55455, USA. NR 21 TC 6 Z9 6 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0178-7683 J9 Z PHYS D ATOM MOL CL JI Z. Phys. D-Atoms Mol. Clusters PD MAY PY 1993 VL 26 SU S BP S156 EP S158 PG 3 WC Physics, Atomic, Molecular & Chemical SC Physics GA ME190 UT WOS:A1993ME19000052 ER PT J AU ZHANG, XC JIN, Y HEWITT, TD SANGSIRI, T KINGSLEY, LE WEINER, M AF ZHANG, XC JIN, Y HEWITT, TD SANGSIRI, T KINGSLEY, LE WEINER, M TI MAGNETIC SWITCHING OF THZ BEAMS SO APPLIED PHYSICS LETTERS LA English DT Article ID TERAHERTZ BEAMS AB We demonstrate the use of a magnetic field to switch and to control the direction and polarization of a THz beam radiated from a semiconductor emitter. C1 USA,RES LAB,CTR PULSE POWER,FT MONMOUTH,NJ 07703. RP ZHANG, XC (reprint author), RENSSELAER POLYTECH INST,DEPT PHYS,TROY,NY 12180, USA. RI Zhang, Xi-Cheng/G-1306-2016 OI Zhang, Xi-Cheng/0000-0003-3721-1357 NR 9 TC 96 Z9 99 U1 1 U2 7 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 26 PY 1993 VL 62 IS 17 BP 2003 EP 2005 DI 10.1063/1.109514 PG 3 WC Physics, Applied SC Physics GA KY864 UT WOS:A1993KY86400001 ER PT J AU ZUKAS, WX AF ZUKAS, WX TI RELAXATIONS IN THERMOSETS .23. DIELECTRIC STUDIES OF CURING KINETICS OF AN EPOXIDE WITH DIAMINES OF VARYING CHAIN LENGTHS - COMMENT SO MACROMOLECULES LA English DT Note ID CURE RP ZUKAS, WX (reprint author), USA,RES LAB,MAT DIRECTORATE,POLYMER RES BRANCH,WATERTOWN,MA 02172, USA. NR 8 TC 15 Z9 15 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD APR 26 PY 1993 VL 26 IS 9 BP 2390 EP 2391 DI 10.1021/ma00061a039 PG 2 WC Polymer Science SC Polymer Science GA KZ776 UT WOS:A1993KZ77600039 ER PT J AU ERICE, A MAYERS, DL STRIKE, DG SANNERUD, KJ MCCUTCHAN, FE HENRY, K BALFOUR, HH AF ERICE, A MAYERS, DL STRIKE, DG SANNERUD, KJ MCCUTCHAN, FE HENRY, K BALFOUR, HH TI BRIEF REPORT - PRIMARY INFECTION WITH ZIDOVUDINE-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Note ID HIV-1 REVERSE-TRANSCRIPTASE; REDUCED SENSITIVITY; AZT; MUTATIONS; THERAPY C1 UNIV MINNESOTA,SCH MED,DEPT LAB MED & PATHOL,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,SCH MED,DEPT MED,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,SCH MED,DEPT PEDIAT,MINNEAPOLIS,MN 55455. AIDS CLIN TRIALS UNIT,MINNEAPOLIS,MN. WALTER REED ARMY INST RES,USN,MED RES INST,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307. HENRY M JACKSON FDN RES LAB,ROCKVILLE,MD. GRP HLTH INC,RIVERSIDE MED CTR,MINNEAPOLIS,MN. ST PAUL RAMSEY MED CTR,ST PAUL,MN 55101. FU NIADDK NIH HHS [AM13083]; NIAID NIH HHS [AI27761] NR 20 TC 218 Z9 221 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD APR 22 PY 1993 VL 328 IS 16 BP 1163 EP 1165 DI 10.1056/NEJM199304223281605 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA KY447 UT WOS:A1993KY44700005 PM 8455683 ER PT J AU BOYLE, T AVIS, I MULSHINE, JL GEMSKI, P FINE, RL JETT, M AF BOYLE, T AVIS, I MULSHINE, JL GEMSKI, P FINE, RL JETT, M TI STIMULATION OF LIPOXYGENASE METABOLITES IN NCI-H209 LUNG-CELLS REFLECTS TOXIC VS NONTOXIC RESPONSES - CYCLOOXYGENASE INHIBITOR INCREASED PRODUCTION OF LEUKOTRIENES FOR BOTH AGONISTS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. NIH,DCPC,BPRB,BETHESDA,MD 20892. VET ADM MED CTR,DURHAM,NC 27705. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 20 PY 1993 VL 7 IS 7 BP A1309 EP A1309 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KY848 UT WOS:A1993KY84801576 ER EF