FN Thomson Reuters Web of Science™ VR 1.0 PT J AU SANCHEZ, JL HAYASHI, KE KRUGER, HF MEZA, R ENGLISH, CK VIDAL, W SVENNERHOLM, AM TAYLOR, DN AF SANCHEZ, JL HAYASHI, KE KRUGER, HF MEZA, R ENGLISH, CK VIDAL, W SVENNERHOLM, AM TAYLOR, DN TI IMMUNOLOGICAL RESPONSE TO VIBRIO-CHOLERAE O1 INFECTION AND AN ORAL CHOLERA VACCINE AMONG PERUVIANS SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE CHOLERA; VACCINE; EFFICACY; SAFETY ID TOXIGENIC ESCHERICHIA-COLI; B-SUBUNIT; IMMUNOGENICITY; DIARRHEA; SAFETY; PROTECTION; VOLUNTEERS AB A 'double-blind', randomized, placebo controlled study of an oral inactivated whole cell plus recombinant B subunit (WC/rBS) cholera vaccine was conducted during February-March 1992 in Peru in 346 military recruits, 307 (89%) of whom received 2 oral doses of vaccine or Escherichia coli K12 placebo 2 weeks apart. Paired serum samples were obtained from 155 (50%) of the recipients of 2 doses. An epidemic of cholera took place between doses. No difference in cholera attack rates was detected between vaccine and placebo recipients after one dose (8% versus 14%). Seroconversion (4-fold or higher increase in vibriocidal antibody titres) was detected in 90% and 80% of vaccine and placebo recipients, respectively, with low pre-existing vibriocidal titres (< 0.01). The anti-cholera toxin seroconversion rate among those with low pre-existing titres was higher in vaccinated subjects (97%) than in placebo recipients (68%) (P < 0.01). Administration of 2 doses of WC/rBS vaccine concomitantly with natural V. cholerae O1 infection enhanced the serum anti-cholera toxin response. The immune response to the whole cell component of the vaccine was reduced by high pre-existing vibriocidal antibody titres. C1 USN,ENVIRONM & PREVENT MED UNIT 2,NORFOLK,VA 23511. USN,MED RES INST DETACHMENT,LIMA,PERU. CTR MED NAVAL,CALLAO,PERU. UNIV GOTHENBURG,DEPT MED MICROBIOL & IMMUNOL,GOTHENBURG,SWEDEN. RP SANCHEZ, JL (reprint author), USA,MED RES UNIT BRAZIL,AMER CONSULATE RIO,UNIT 3501,APO,AA 34030, USA. NR 16 TC 8 Z9 8 U1 0 U2 3 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD SEP-OCT PY 1995 VL 89 IS 5 BP 542 EP 545 DI 10.1016/0035-9203(95)90103-5 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA TH049 UT WOS:A1995TH04900029 PM 8560536 ER PT J AU ALVING, BM WEINSTEIN, MJ FINLAYSON, JS MENITOVE, JE FRATANTONI, JC AF ALVING, BM WEINSTEIN, MJ FINLAYSON, JS MENITOVE, JE FRATANTONI, JC TI FIBRIN SEALANT - SUMMARY OF A CONFERENCE ON CHARACTERISTICS AND CLINICAL USES SO TRANSFUSION LA English DT Editorial Material ID TOPICAL BOVINE THROMBIN; FACTOR-V; CARDIAC OPERATIONS; GLUE; ANTIBODIES; PREVENTION; ADHESIVE; SURGERY C1 US FDA,CTR BIOL EVALUAT & RES,HEMOSTASIS LAB,BETHESDA,MD. US FDA,CTR BIOL EVALUAT & RES,DIV HEMATOL,BETHESDA,MD. UNIV CINCINNATI,HOXWOTH BLOOD CTR,CINCINNATI,OH. RP ALVING, BM (reprint author), WALTER REED ARMY MED CTR,DEPT HEMATOL & VASC BIOL,6800 GEORGIA AVE NW,WASHINGTON,DC 20307, USA. NR 23 TC 88 Z9 92 U1 0 U2 2 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 1995 VL 35 IS 9 BP 783 EP 790 DI 10.1046/j.1537-2995.1995.35996029166.x PG 8 WC Hematology SC Hematology GA RW513 UT WOS:A1995RW51300015 PM 7570942 ER PT J AU SRIVASTAVA, AK PUTNAK, JR WARREN, RL HOKE, CH AF SRIVASTAVA, AK PUTNAK, JR WARREN, RL HOKE, CH TI MICE IMMUNIZED WITH A DENGUE TYPE-2 VIRUS-E AND NS1 FUSION PROTEIN MADE IN ESCHERICHIA-COLI ARE PROTECTED AGAINST LETHAL DENGUE VIRUS-INFECTION SO VACCINE LA English DT Article DE DEN-2 VIRUS; EXPRESSION; PROTECTION; VACCINE ID YELLOW-FEVER VIRUS; STRUCTURAL PROTEINS; NUCLEOTIDE-SEQUENCE; NONSTRUCTURAL PROTEINS; MONOCLONAL-ANTIBODIES; MOLECULAR-BIOLOGY; ENCEPHALITIS; GLYCOPROTEIN; GENE; ENVELOPE AB A gene fragment encoding the C-terminal 204 amino acids (AA) from the structural envelope glycoprotein (E) and the N-terminal 65 AA from non-structural protein one (NS1) of dengue type 2 virus (DEN-2) was expressed in Escherichia coli (E. coli) as a fusion protein with staphylococcal protein A. The recombinant fusion protein was purified and analysed for its antigenicity, its immunogenicity and its ability to protect mice against lethal challenge with live DEN-2 virus. The recombinant protein was found to be reactive with anti-DEN-2 polyclonal and monoclonal antibodies. Mice immunized with the purified fusion protein made anti-DEN-2 antibodies measured by the hemagglutination-inhibition (HI) and neutralization (N) tests, and were protected against lethal challenge with DEN-2 virus administered by intracranial inoculation. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. RP SRIVASTAVA, AK (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC 20307, USA. NR 65 TC 55 Z9 58 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP SN 0264-410X J9 VACCINE JI Vaccine PD SEP PY 1995 VL 13 IS 13 BP 1251 EP 1258 DI 10.1016/0264-410X(94)00059-V PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA RX647 UT WOS:A1995RX64700016 PM 8578812 ER PT J AU MCDONNELL, JA AF MCDONNELL, JA TI THE WHITE-EARTH TRAGEDY, ETHNICITY AND DISPOSSESSION AT A MINNESOTA ANISHINAABE RESERVATION, 1889-1920 - MEYER,ML SO WESTERN HISTORICAL QUARTERLY LA English DT Book Review RP MCDONNELL, JA (reprint author), USA CORPS ENGINEERS,ALEXANDRIA,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WESTERN HISTORY ASSOCIATION PI LOGAN PA UTAH STATE UNIV, UMC 0740, LOGAN, UT 84322 SN 0043-3810 J9 WESTERN HIST QUART JI West. Hist. Q. PD FAL PY 1995 VL 26 IS 3 BP 390 EP 391 DI 10.2307/970677 PG 2 WC History SC History GA RP079 UT WOS:A1995RP07900024 ER PT J AU PRINCE, JT MCGRATH, KP DIGIROLAMO, CM KAPLAN, DL AF PRINCE, JT MCGRATH, KP DIGIROLAMO, CM KAPLAN, DL TI CONSTRUCTION, CLONING, AND EXPRESSION OF SYNTHETIC GENES ENCODING SPIDER DRAGLINE SILK SO BIOCHEMISTRY LA English DT Article ID NEPHILA-CLAVIPES; ORB WEB; FIBROIN; PROTEIN; ARGIOPE; MODEL AB Synthetic genes encoding recombinant spider silk proteins have been constructed, cloned, and expressed. Protein sequences were derived from Nephila clavipes dragline silk proteins and reverse-translated to the corresponding DNA sequences. Codon selection was chosen to maximize expression levels in Escherichia coli. DNA ''monomer'' sequences were multimerized to encode high molecular weight synthetic spider silks using a ''head-to-tail'' construction strategy. Multimers were cloned into a prokaryotic expression vector and the encoded silk proteins were expressed in E. coli upon induction with IPTG.(1) Four multimers, ranging in size from 14.7 to 41.3 kDa, were chosen for detailed analysis. These proteins were isolated by immobilized metal affinity chromatography and purified using reverse-phase HPLC. The composition and identity of the purified proteins were confirmed by amino acid composition analysis, N-terminal sequencing, laser desorption mass spectroscopy, and Western analysis using antibodies reactive to native spider dragline silk. Circular dichroism measurements indicate that the synthetic spider silks have substantial beta-sheet structure. C1 USA, NATICK RES DEV & ENGN CTR, DIV BIOTECHNOL, NATICK, MA 01760 USA. GEOCENTERS INC, NEWTON, MA 02159 USA. NR 46 TC 176 Z9 187 U1 4 U2 33 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD AUG 29 PY 1995 VL 34 IS 34 BP 10879 EP 10885 DI 10.1021/bi00034a022 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA RT655 UT WOS:A1995RT65500022 PM 7662669 ER PT J AU BHATTACHARJEE, AK HADFIELD, TL TAYLOR, R ZOLLINGER, WD VANDEVERG, L WARREN, RL YUAN, L HOOVER, DL AF BHATTACHARJEE, AK HADFIELD, TL TAYLOR, R ZOLLINGER, WD VANDEVERG, L WARREN, RL YUAN, L HOOVER, DL TI IMMUNOGENICITY OF BRUCELLA-ABORTUS AND BRUCELLA-MELITENSIS LIPOPOLYSACCHARIDES IN MICE AND OPTIMIZATION OF VACCINE FORMULATIONS AND REGIMEN SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 ARMED FORCES INST PATHOL,DIV MICROBIOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 20 PY 1995 VL 210 BP 2 EP CARB PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA RP256 UT WOS:A1995RP25600493 ER PT J AU CHATTERJEE, S WALKER, JE AF CHATTERJEE, S WALKER, JE TI ESR AND WATER ACTIVITY OF SPIN-LABELED BOVINE TENDON COLLAGEN SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 FRAMINGHAM STATE COLL,FRAMINGHAM,MA 01701. USA,NATICK RES & DEV COMMAND,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 20 PY 1995 VL 210 BP 14 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA RP256 UT WOS:A1995RP25600014 ER PT J AU FAMINI, GR WILSON, LY AF FAMINI, GR WILSON, LY TI USING THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS - SOME MODELS AND APPLICATIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR DEV & ENGN,EDGEWOOD RES,ABERDEEN PROVING GROUND,MD 21010. LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 20 PY 1995 VL 210 BP 26 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA RP256 UT WOS:A1995RP25601301 ER PT J AU KIM, HJ TAUB, IA CHOI, YM PRAKASH, A AF KIM, HJ TAUB, IA CHOI, YM PRAKASH, A TI VALIDATION OF OHMIC HEATING AND MICROWAVE STERILIZATION USING CHEMICAL MARKERS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RD&E CTR,NATICK,MA 01760. KOREA UNIV,INST BIOTECHNOL,SEOUL,SOUTH KOREA. OHIO STATE UNIV,DEPT FOOD SCI,COLUMBUS,OH 43210. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 20 PY 1995 VL 210 BP 34 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA RP256 UT WOS:A1995RP25600034 ER PT J AU WHITE, WE DONOVAN, WH AF WHITE, WE DONOVAN, WH TI MOLECULAR-ORBITAL STUDIES OF METHOXYCYCLOHEPTATRIENE ISOMERS - SEMIEMPIRICAL, AB-INITIO AND DFT RESULTS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES,CTR DEV & ENGN,ERDEC,SCBRD RTC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 20 PY 1995 VL 210 BP 87 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA RP256 UT WOS:A1995RP25601362 ER PT J AU WHITE, WE DONOVAN, WH AF WHITE, WE DONOVAN, WH TI SEMIEMPIRICAL STUDIES OF THE HYDROLYSIS OF ORGANOPHOSPHORUS HALOGENATES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CHEM RES,CTR DEV & ENGN,SCBRD RTC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 20 PY 1995 VL 210 BP 144 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA RP256 UT WOS:A1995RP25601418 ER PT J AU BUNTE, SW RICE, BM CHABALOWSKI, CF AF BUNTE, SW RICE, BM CHABALOWSKI, CF TI AB-INITIO POTENTIAL-ENERGY SURFACE OF THE REACTION HNO+NO-]N2O+OH SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,AMSRL,WT,PC,ABERDEEN PROVINO GROUND,MD 21005. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 20 PY 1995 VL 210 BP 159 EP PHYS PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA RP259 UT WOS:A1995RP25901074 ER PT J AU ZHOU, PG SAMUELSON, L ALVA, KS BLUMSTEIN, A AF ZHOU, PG SAMUELSON, L ALVA, KS BLUMSTEIN, A TI AMPHIPHILIC IONIC POLYACETYLENES - SELF-ASSEMBLY AND L-B MULTILAYERS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,DEPT CHEM,POLYMER SCI PROGRAM,LOWELL,MA 01825. KDEPT PHYS,LOWELL,MA. USA,NATICK RES & DEV LABS,DIV BIOTECHNOL,CTR DEV & ENGN,NATICK,MA 01760. UNIV MASSACHUSETTS,CTR ADV MAT,LOWELL,MA 01854. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 20 PY 1995 VL 210 BP 164 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA RP259 UT WOS:A1995RP25901636 ER PT J AU OKUNJI, CO JACKSON, JE TALLY, JD IWU, MM AF OKUNJI, CO JACKSON, JE TALLY, JD IWU, MM TI BIOLOGICALLY-ACTIVE SAPONINS FROM 2 DRACAENA SPECIES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 20 PY 1995 VL 210 BP 235 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA RP256 UT WOS:A1995RP25600227 ER PT J AU ROWE, CM KUIVINEN, KC AF ROWE, CM KUIVINEN, KC TI SIMULATION OF SUMMER SNOWMELT ON THE GREENLAND ICE-SHEET USING A ONE-DIMENSIONAL MODEL SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID ENERGY-BALANCE; TEMPERATURE; MELTWATER; COVER; SNOWPACK; CLIMATE; HEAT AB A one-dimensional heat and mass balance model of a snowpack over frozen soil was modified for use in glacial environments. The model solves a set of governing equations for the energy and mass balances of the snow, subject to observed meteorological conditions at the upper boundary and the assumption of a steady state at the lower boundary. The initial state of the snowpack is defined by the temperature, density and grain size profiles at the beginning of the simulation period. The data used to test the model on the Greenland ice sheet are a subset of the meteorological and surface data collected during the 1990 summer field season by the Swiss Federal Institute of Technology (ETH) Greenland Expedition. The site was located near the equilibrium line elevation on the west slope of the ice sheet. The relatively large amount of snowmelt experienced at this site during the summer of 1990 provides a robust test of the snowmelt model. Both the simulated height and mass of the snowpack agree well with the observations. The evolution of profiles of temperature, density and liquid water content also conform to our expectations of the physical changes taking place in the snowpack during melt. Results from the present model. are also compared to those from a similar model and differences between the models are discussed. C1 UNIV NEBRASKA, SNOW & ICE RES GRP, LINCOLN, NE 68588 USA. USA, COLD REG RES & ENGN LAB, GEOPHYS SCI BRANCH, HANOVER, NH 03755 USA. RP ROWE, CM (reprint author), UNIV NEBRASKA, DEPT GEOG, METROL CLIMATOL PROGRAM, LINCOLN, NE 68588 USA. NR 52 TC 21 Z9 21 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD AUG 20 PY 1995 VL 100 IS D8 BP 16265 EP 16273 DI 10.1029/95JD01384 PG 9 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA RU107 UT WOS:A1995RU10700003 ER PT J AU CHYLEK, P VIDEEN, G NGO, D PINNICK, RG KLETT, JD AF CHYLEK, P VIDEEN, G NGO, D PINNICK, RG KLETT, JD TI EFFECT OF BLACK CARBON ON THE OPTICAL-PROPERTIES AND CLIMATE FORCING OF SULFATE AEROSOLS SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID 2-STREAM APPROXIMATIONS; PARTICULATE CARBON; RADIATIVE-TRANSFER; ELEMENTAL CARBON; UNITED-STATES; SCATTERING; PARTICLES; SPHERES; URBAN AB We study the optical properties of anthropogenic sulfate aerosols containing black carbon using a recently developed exact solution of the scattering problem for a spherical particle (sulfate aerosol) containing an eccentrically located spherical inclusion (black carbon). We present the expression for the change of planetary albedo due to addition of an absorbing, but optically thin aerosol layer and estimate the effect of the black carbon within the sulfate aerosol layer on the aerosol direct radiative forcing. The black carbon within the sulfate aerosol reduces the expected sulfate direct cooling effect by about 0.034 W/m(2) for each 1% of the black carbon to sulfate mass mixing ratio. Thus the presence of black carbon within sulfate in the background aerosol does not significantly change the previous estimates of the global aerosol direct cooling effect. However, in regions where the black carbon in sulfate concentrations are of the order of 5% or more, the local and regional effects are significant. C1 DALHOUSIE UNIV, DEPT OCEANOG, HALIFAX, NS B3H 3J5, CANADA. NEW MEXICO STATE UNIV, DEPT PHYS, LAS CRUCES, NM 88003 USA. PAR ASSOCIATES, LAS CRUCES, NM 88003 USA. USA, RES LAB, WHITE SANDS MISSILE RANGE, NM 88002 USA. SUNY ALBANY, DEPT ATMOSPHER SCI, ALBANY, NY 12222 USA. RP CHYLEK, P (reprint author), DALHOUSIE UNIV, DEPT PHYS, ATMOSPHER SCI PROGRAM, HALIFAX, NS B3H 3J5, CANADA. NR 31 TC 118 Z9 127 U1 2 U2 13 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD AUG 20 PY 1995 VL 100 IS D8 BP 16325 EP 16332 DI 10.1029/95JD01465 PG 8 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA RU107 UT WOS:A1995RU10700007 ER PT J AU KARLE, JM OLMEDA, R FREEMAN, SG SCHROEDER, AC AF KARLE, JM OLMEDA, R FREEMAN, SG SCHROEDER, AC TI QUANTIFICATION OF THE INDIVIDUAL ENANTIOMER PLASMA-CONCENTRATIONS OF THE CANDIDATE ANTIMALARIAL AGENT N-4-[2,6-DIMETHOXY-4-METHYL-5-[(3-TRIFLUOROMETHYL)PHENOXY]-8-QUINOLINYL] -1,4-PENTANEDIAMINE (WR-238,605) SO JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS LA English DT Article AB A high-performance liquid chromatographic method was developed to quantitate the plasma concentrations of the individual enantiomers of a candidate 8-aminoquinoline antimalarial agent WR 238,605 (I). The method employed one-step liquid extraction of a 0.5-ml plasma sample followed by direct injection of the extract through a chiral column and detection by fluorescence. Quantification was achieved using an internal standard. The limit of quantification was 10 ng/ml for each enantiomer. The method is sufficiently sensitive to quantitate the plasma concentrations of both enantiomers for 30 days following a single oral dose of 400 mg of the antimalarial agent administered as the racemic succinate salt to healthy human male volunteers. In nearly all samples taken 12 h to 30 days post-dose from three subjects, the difference in the plasma concentrations of the two enantiomers is less than 10%. C1 US FDA,DIV ONCOL & PULM DRUG PROD,ROCKVILLE,MD 20857. RP KARLE, JM (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 6 TC 7 Z9 7 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4347 J9 J CHROMATOGR B JI J. Chromatogr. B-Biomed. Appl. PD AUG 18 PY 1995 VL 670 IS 2 BP 251 EP 257 DI 10.1016/0378-4347(95)00166-2 PG 7 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA RU444 UT WOS:A1995RU44400007 PM 8548015 ER PT J AU WU, JJ CHIEN, LC AF WU, JJ CHIEN, LC TI SOLUTIONS TO A GENERAL FORCED NONLINEAR OSCILLATIONS PROBLEM SO JOURNAL OF SOUND AND VIBRATION LA English DT Article ID SYSTEMS AB In this paper we present a mixed ''multiple time scale - harmonic balance'' (MHB) method for a quite general non-linear oscillations problem subject to a periodic force. The MHB differs from the more traditional multiple time scale (MS) method in that it uses two separate procedures for the solutions; (1) obtaining the form of solution using an almost trivial procedure and (2) balancing of the harmonic terms with a simple iteration. These procedures are demonstrated. The advantage of this alternative approach to MS is that it is easier to use. In fact, all the formulas for the transient (in terms of various harmonic components as well as the recovered solution to the given differential equation), and steady state solutions to the superharmonic, subharmonic and primary resonance cases are presented together. Finally, numerical results are presented to demonstrate the validity of the method. Examples for superharmonic, subharmonic and primary resonances are provided. These results indicate that MHB provide excellent approximations for sufficiently small values of epsilon in most cases. For several cases for parameters with moderately magnitudes, MHB still yields quite good approximations. Some observations on the so-called ''steady state'' solutions are included. C1 NATL CENT UNIV,CHUNGLI 32054,TAIWAN. ACAD SINICA,TAIPEI,TAIWAN. RP WU, JJ (reprint author), USA,RES OFF,POB 12211,RES TRIANGLE PK,NC 27709, USA. NR 10 TC 2 Z9 2 U1 0 U2 0 PU ACADEMIC PRESS (LONDON) LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0022-460X J9 J SOUND VIB JI J. Sound Vibr. PD AUG 17 PY 1995 VL 185 IS 2 BP 247 EP 264 DI 10.1006/jsvi.1995.0378 PG 18 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA RP564 UT WOS:A1995RP56400005 ER PT J AU SAETHER, E AF SAETHER, E TI EXPLICIT DETERMINATION OF ELEMENT STIFFNESS MATRICES IN THE HYBRID STRESS METHOD SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article DE FINITE ELEMENT ANALYSIS; HYBRID STRESS METHOD ID RATIONAL APPROACH; FORMULATION; INVARIANT AB The hybrid stress method has demonstrated many improvements over conventional displacement-based formulations. A main detraction from the method, however, has been the higher computatational cost in forming element stiffness coefficients due to matrix inversions and manipulations as required by the technique. By utilizing permissible held transformations of initially assumed stresses, a spanning set of orthonormalized stress modes can be generated which simplify the matrix equations and allow explicit expressions for element stiffness coefficients to be derived. The developed methodology is demonstrated using several selected 2-D quadrilateral and 3-D hexahedral elements. RP SAETHER, E (reprint author), USA,RES LAB,MAT DIRECTORATE,COMPUTAT MECH GRP,AMSRL,MA,PC,WATERTOWN,MA 02172, USA. NR 18 TC 5 Z9 7 U1 0 U2 2 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0029-5981 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD AUG 15 PY 1995 VL 38 IS 15 BP 2547 EP 2571 DI 10.1002/nme.1620381505 PG 25 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA RK021 UT WOS:A1995RK02100004 ER PT J AU SHEN, H DUTTA, M AF SHEN, H DUTTA, M TI FRANZ-KELDYSH OSCILLATIONS IN MODULATION SPECTROSCOPY SO JOURNAL OF APPLIED PHYSICS LA English DT Review ID 2-DIMENSIONAL ELECTRON-GAS; 001 N-TYPE; MOBILITY TRANSISTOR STRUCTURES; GAAS DOPING SUPERLATTICES; QUANTUM WELL STRUCTURES; MOLECULAR-BEAM EPITAXY; SPACE-CHARGE REGION; SURFACE FERMI LEVEL; PHOTOREFLECTANCE CHARACTERIZATION; DIFFERENTIAL PHOTOREFLECTANCE AB In the presence of an electric field, the dielectric constant of a semiconductor exhibits Franz-Keldysh oscillations (FKO), which can be detected by modulated reflectance. Although it could be a powerful and simple method to study the electric fields/charge distributions in various semiconductor structures, in the past it has proven to be more complex. This is due to nonuniform fields and impurity induced broadening, which reduce the number of detectible Franz-Keldysh oscillations, and introduce uncertainties into the measurement. In 1989, a new structure, surface-undoped-doped (s-i-n(+)/s-i-p(+)) was developed, which allows the observation of a large number of FKOs and, hence, permitting accurate determination of electric fields. We present a review of the work on measuring electric fields in semiconductors with a particular emphasis on microstructures using the specialized layer sequence. We first discuss the general theory of modulation techniques dwelling on the approximations and their relevance. The case of uniform field, obtained with this specialized structure as well as that of the nonuniform field, are addressed. The various experimental techniques are also briefly reviewed. We then summarize the various experimental results obtained in the last few years using these special structures and FKOs and find that, even in this short period, good use has been made of the technique and the structure. This is followed by a brief review of the work on nonuniform fields. In this case, the work on actual device structures has significant technological implications. Important issues such as metallization and processing, the effects of surface treatment and thermal annealing, Schottky barrier heights of different metals, piezoelectric fields in (111) grown strained InGaAs/GaAs quantum wells, and Fermi level in low-temperature grown GaAs have been studied using this structure. This structure has also been used to study the dynamics of photomodulation, revealing the nature of the cw photoreflectance. (C) 1995 American Institute of Physics. RP USA, RES LAB, ELECTR & POWER SOURCES DIRECTORATE, AMSRL ER EF, FT MONMOUTH, NJ 07703 USA. NR 125 TC 247 Z9 249 U1 5 U2 49 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 15 PY 1995 VL 78 IS 4 BP 2151 EP 2176 DI 10.1063/1.360131 PG 26 WC Physics, Applied SC Physics GA RP718 UT WOS:A1995RP71800001 ER PT J AU COLE, MW KO, KK PANG, SW AF COLE, MW KO, KK PANG, SW TI THE INFLUENCE OF ION ENERGY, ION FLUX, AND ETCH TEMPERATURE ON THE ELECTRICAL AND MATERIAL QUALITY OF GAAS ETCHED WITH AN ELECTRON-CYCLOTRON-RESONANCE SOURCE SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID RESIDUAL DAMAGE; RAMAN-SCATTERING; SICL4 AB The residual damage incurred to GaAs via etching with a Cl-2/Ar plasma generated by an electron cyclotron resonance (ECR) source was investigated as a function of variations in ion energy, ion flux, and etching temperature. The residual damage and electrical properties of GaAs were strongly influenced by changes in these etching parameters. Lattice damage was incurred in all processing situations in the form of small dislocation loops. GaAs etched at high ion energies with 200 W rf power, exhibited a defect density five times higher than GaAs etched at lower ion energies with 20 W rf power. This enhanced residual damage at the higher rf powers was paralleled by a degradation in the unannealed contact resistance. Higher etch rates, which accompany the higher rf power levels, caused the width of the disordered region to contract as the rf power was elevated. Therefore, the residual etch damage is influenced by both the generation and removal of defects. Increasing the microwave power or ion flux resulted in elevating the residual defect density, surface roughness, and unannealed contact resistance. GaAs etched at high temperatures, similar to 350 degrees C, resulted in a lower contact resistance than GaAs etched at 25 degrees C. The high temperature etching augmented the defect diffusion which in turn lowered the near surface defect density. This decrease in residual damage was deemed responsible for improving the electrical performance at 350 degrees C. The electrical measurements were found to be more sensitive to the density of defects than the vertical extent of disorder beneath the etched surface. Results of this investigation demonstrate that in order to minimize material damage and improve electrical performance, etching with an ECR source should be performed at low rf and microwave powers with a high substrate temperature. (C) 1995 American Institute of Physics. C1 UNIV MICHIGAN,DEPT ELECT ENGN & COMP SCI,ANN ARBOR,MI 48109. RP COLE, MW (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. RI Pang, Stella/A-7770-2012 OI Pang, Stella/0000-0002-4330-0877 NR 11 TC 5 Z9 5 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 15 PY 1995 VL 78 IS 4 BP 2712 EP 2715 DI 10.1063/1.360067 PG 4 WC Physics, Applied SC Physics GA RP718 UT WOS:A1995RP71800082 ER PT J AU VASSILOPOULOS, D KOVACS, B TSOKOS, GC AF VASSILOPOULOS, D KOVACS, B TSOKOS, GC TI TCR/CD3 COMPLEX-MEDIATED SIGNAL-TRANSDUCTION PATHWAY IN T-CELLS AND T-CELL LINES FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS SO JOURNAL OF IMMUNOLOGY LA English DT Article ID PROTEIN-KINASE-C; INCREASED INTRACELLULAR CALCIUM; HUMAN LYMPHOCYTE-T; ANTIGEN RECEPTOR; INOSITOL PHOSPHATES; TYROSINE KINASES; RHEUMATOID-ARTHRITIS; PHOSPHOLIPASE-C; IMMUNE FUNCTION; LPR/LPR MICE AB We studied the TCR/CD3 complex-mediated signal transduction pathway in freshly isolated T cells and T cell lines from patients with systemic lupus erythematosus (SLE). The peak and 5-min anti-CD3 mAb-mediated free intracytoplasmic Ca2+ concentration ([Ca2+](i)) increase was statistically significant higher in fresh T cells from SLE patients than in control T cells. Increased CD3-mediated [Ca2+](i) responses were observed in T cells from patients with SLE but not in T cells from other rheumatic diseases. Furthermore, significantly increased CD3-mediated [Ca2+](i) responses were observed in T cell lines from SLE patients but not from controls. Although the [Ca2+](i) response did not correlate with the global SLE disease activity or individual clinical manifestations, it was significantly higher in the group of patients who were not on treatment. Both CD4(+) and CD8(+) T cell subsets from peripheral blood cells and T cell lines displayed higher CD3-mediated [Ca2+](i) responses than their normal counterparts. The peak of the response occurred earlier in the patient than in the normal group. The amount of Ca2+ that was released from the intracellular stores was higher in lupus than control T cells. The TCR/CD3-induced production of inositol phosphate metabolites in SLE cells was comparable with controls. The sarcoplasmic and endoplasmic reticulum Ca2+-ATPase inhibitor thapsigargin-induced [Ca2+](i) response was similar in both SLE and normal T cells. Our experiments demonstrate for the first time a definite abnormality in the early steps of the TCR/CD3-mediated signal transduction pathway in T cells from SLE patients that involves increased release of Ca2+ from intracellular stores. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 82 TC 117 Z9 125 U1 1 U2 4 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD AUG 15 PY 1995 VL 155 IS 4 BP 2269 EP 2281 PG 13 WC Immunology SC Immunology GA RN464 UT WOS:A1995RN46400065 PM 7636273 ER PT J AU YAO, J AGRAWAL, GP GALLION, P BOWDEN, CM AF YAO, J AGRAWAL, GP GALLION, P BOWDEN, CM TI SEMICONDUCTOR-LASER DYNAMICS BEYOND THE RATE-EQUATION APPROXIMATION SO OPTICS COMMUNICATIONS LA English DT Article ID LINEWIDTH ENHANCEMENT FACTOR; NONLINEAR GAIN; AMPLIFIERS AB Starting from the density-matrix equations, we have obtained a new set of generalized macroscopic Maxwell-Bloch equations for semiconductor lasers which can be used to study ultrafast phenomena at femtosecond time scales where the conventional rate equations are no longer valid. The band-structure details are included in these Maxwell-Bloch equations through two parameters kappa and zeta which can be determined numerically by using their definitions or obtained experimentally by fitting the measured data. In the limit of ultrafast intraband relaxation (the rate-equation approximation), these equations reduce to the conventional rate equations. As an illustration of the usefulness of the new Maxwell-Bloch equations we have obtained the analytic expressions for several important laser parameters such as the differential gain, the linewidth enhancement factor and the nonlinear gain coefficient, in terms of the parameters kappa and zeta when the semiconductor laser is operating continuously (the cw operation). The results obtained from these analytic expressions agree with those obtained numerically from the density-matrix equations under steady-state conditions by integrating over the density of states. C1 ECOLE NATL SUPER TELECOMMUN BRETAGNE,DEPT COMMUN,F-75634 PARIS 13,FRANCE. USA,MISSILE COMMAND,ST,WS,RD,AMSMI,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898. RP YAO, J (reprint author), UNIV ROCHESTER,INST OPT,ROCHESTER,NY 14627, USA. RI Agrawal, Govind/D-5380-2013 OI Agrawal, Govind/0000-0003-4486-8533 NR 15 TC 45 Z9 45 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD AUG 15 PY 1995 VL 119 IS 1-2 BP 246 EP 255 DI 10.1016/0030-4018(95)00245-4 PG 10 WC Optics SC Optics GA RP774 UT WOS:A1995RP77400041 ER PT J AU MAZUMDER, MM CHEN, G KINDLMANN, PJ GILLESPIE, JB AF MAZUMDER, MM CHEN, G KINDLMANN, PJ GILLESPIE, JB TI TEMPERATURE-DEPENDENT WAVELENGTH SHIFTS OF DYE LASING IN MICRODROPLETS WITH A THERMOCHROMIC ADDITIVE SO OPTICS LETTERS LA English DT Article ID FLUORESCENCE THERMOMETRY AB The lasing spectra from a Rhodamine B-doped microdroplet (85% isopropanol and 15% water) with a thermochromic additive (CoCl2.6H(2)O) have been observed to shift progressively toward blue as the droplet temperature is gradually increased. The absorption of the thermochromic additive increases as the temperature of the solution is increased. The mechanism of temperature-dependent absorption is reviewed. We propose that the temperature-dependent shifting of the lasing spectra might be used far the determination of the droplet temperature. (C) 1995 Optical Society of America C1 YALE UNIV,CTR LASER DIAGNOST,NEW HAVEN,CT 06520. USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP MAZUMDER, MM (reprint author), YALE UNIV,DEPT APPL PHYS,NEW HAVEN,CT 06520, USA. NR 12 TC 11 Z9 11 U1 1 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD AUG 15 PY 1995 VL 20 IS 16 BP 1668 EP 1670 DI 10.1364/OL.20.001668 PG 3 WC Optics SC Optics GA RN535 UT WOS:A1995RN53500002 PM 19862118 ER PT J AU ZHANG, Z DAVIS, HT MAIER, RS KROLL, DM AF ZHANG, Z DAVIS, HT MAIER, RS KROLL, DM TI ASYMPTOTIC SHAPE OF ELASTIC NETWORKS SO PHYSICAL REVIEW B LA English DT Article ID MEMBRANES AB The shapes of large decorated icosahedron elastic networks are determined by minimizing the total elastic energy. In agreement with recent theoretical predictions, it is found that the asymptotic shape is a flat-sided polyhedron in which the radius of curvature at the edges scales as N-1/3, where N is proportional to the surface area. The total energy of these networks scales as N-1/6. Extremely large system sizes are needed to observe this behavior. It is also shown that for sufficiently large networks, the mean curvature is negative over a large portion of the triangular faces of the icosahedron. Analogous scaling behavior should occur generally at ridges connecting discrete disclinations in elastic sheets. C1 USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415. UNIV MINNESOTA,DEPT MED CHEM,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55455. RP ZHANG, Z (reprint author), UNIV MINNESOTA,DEPT CHEM ENGN & MAT SCI,MINNEAPOLIS,MN 55455, USA. NR 13 TC 14 Z9 14 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD AUG 15 PY 1995 VL 52 IS 7 BP 5404 EP 5413 DI 10.1103/PhysRevB.52.5404 PG 10 WC Physics, Condensed Matter SC Physics GA RR502 UT WOS:A1995RR50200113 ER PT J AU DILLON, DC DAY, CH WHITTLE, JA MAGILL, AJ REED, SG AF DILLON, DC DAY, CH WHITTLE, JA MAGILL, AJ REED, SG TI CHARACTERIZATION OF A LEISHMANIA-TROPICA ANTIGEN THAT DETECTS IMMUNE-RESPONSES IN DESERT-STORM VISCEROTROPIC LEISHMANIASIS PATIENTS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE PARASITE; DIAGNOSIS; REPETITIVE EPITOPE; SUBCLASS ID VISCERAL LEISHMANIASIS; TRYPANOSOMA-CRUZI; IGE; IDENTIFICATION; INTERLEUKIN-4; ANTIBODY AB A chronic debilitating parasitic infection, viscerotropic leishmaniasis (VTL), has been described in Operation Desert Storm veterans, Diagnosis of this disease, caused by Leishmania tropica, has been difficult due to low or absent specific immune responses in traditional assays. We report the cloning and characterization of two genomic fragments encoding portions of a single 210-kDa L. tropica protein useful for the diagnosis of VTL in U.S. military personnel. The recombinant proteins encoded by these fragments, recombinant (r) Lt-1 and rLt-2, contain a 33-amino acid repeat that reacts with sera from Desert Storm VTL patients and with sera from L. tropica-infected patients with cutaneous leishmaniasis, Antibody reactivities to rLt-1 indicated a bias toward IgG2 in VTL patient sera, Peripheral blood mononuclear cells from VTL patients produced interferon gamma, but not interleukin 4 or 10, in response to rLt-1. No cytokine production was observed in response to parasite lysate. The results indicate that specific leishmanial antigens may be used to detect immune responses in VTL patients with chronic infections. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. INFECT DIS RES INST,SEATTLE,WA 98104. FU NIAID NIH HHS [AI-25038] NR 23 TC 18 Z9 18 U1 0 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD AUG 15 PY 1995 VL 92 IS 17 BP 7981 EP 7985 DI 10.1073/pnas.92.17.7981 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA RP748 UT WOS:A1995RP74800078 PM 7644524 ER PT J AU GUREVICH, VL PEVZNER, VB IAFRATE, G AF GUREVICH, VL PEVZNER, VB IAFRATE, G TI RESONANT OPTICAL PHONON GENERATION IN NANOWIRES SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Letter ID CONDUCTANCE AB We investigate a new type of resonant behaviour in the 1D hot-electron ballistic transport in nanostructures. The resonances are manifested by sharp increases in the rate of optical phonon generation and are accompanied by sharp drops in the overall current. They occur whenever the separation between a pair of levels of transverse quantization is equal to the energy of an optical phonon, HBAR omega(0), and a condition for generation of optical phonons eV > HBAR omega(0), is met, where V is the voltage bias across the conductor. We calculate the rate of energy transfer from the electrons to phonons. The ratio between the decrease in electric current power and the rate of energy transfer from electrons to phonons appears to be linearly proportional to the voltage bias. C1 N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP GUREVICH, VL (reprint author), AF IOFFE PHYS TECH INST,DIV SOLID STATE PHYS,POLITEKHNICHESKAYA 26,ST PETERSBURG 194021,RUSSIA. RI V*L Gurevich, Vadim/E-9453-2014 NR 19 TC 3 Z9 3 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0953-8984 J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD AUG 14 PY 1995 VL 7 IS 33 BP L445 EP L450 DI 10.1088/0953-8984/7/33/001 PG 6 WC Physics, Condensed Matter SC Physics GA RP921 UT WOS:A1995RP92100001 ER PT J AU GUREVICH, VL PEVZNER, VB IAFRATE, G AF GUREVICH, VL PEVZNER, VB IAFRATE, G TI ELECTROPHONON RESONANCES IN MESOSCOPIC STRUCTURES SO PHYSICAL REVIEW LETTERS LA English DT Article ID CONDUCTANCE AB A new type of resonant behavior is predicted for the hot electron 1D ballistic transport regime in nanostructures. The resonances are manifested by the sharp drops in current which occur when (i) the separation between a pair of levels of transverse quantization equals the energy of an optical phonon HBAR omega(0), and (ii) a condition for generation of optical phonons eV > HBAR omega(0) is met, where V is the voltage bias across the conductor. C1 N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP GUREVICH, VL (reprint author), AF IOFFE PHYS TECH INST,DIV SOLID STATE PHYS,POLITEKHNICHESKAYA 26,ST PETERSBURG 194021,RUSSIA. RI V*L Gurevich, Vadim/E-9453-2014 NR 19 TC 21 Z9 21 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD AUG 14 PY 1995 VL 75 IS 7 BP 1352 EP 1355 DI 10.1103/PhysRevLett.75.1352 PG 4 WC Physics, Multidisciplinary SC Physics GA RN463 UT WOS:A1995RN46300029 ER PT J AU SADLER, BM AF SADLER, BM TI ACOUSTOOPTIC CYCLOSTATIONARY SIGNAL-PROCESSING SO APPLIED OPTICS LA English DT Article DE ACOUSTOOPTICS; CYCLOSTATIONARY; CYCLIC CORRELATION; CYCLIC SPECTRUM; TRIPLE-PRODUCT PROCESSOR; CYCLIC TRIPLE CORRELATION AB Cyclostationary signal-processing techniques implemented by means of acousto-optics are considered. Cyclic-processing methods are reviewed and motivated, such as the cyclic correlation and the cyclic spectrum. It is shown that the cyclic correlation can be computed at cycle frequencies of interest by use of one-dimensional time-integrating correlators in additive or multiplicative configurations. Detection of cycle frequencies is briefly considered, and a one-dimensional acousto-optic spectrum-analysis approach is described that is effective for amplitude-modulated signals. The problem of computing the two-dimensional cyclic correlation for all cycle frequencies and lags is then considered. This is accomplished by means of an acousto-optic triple-product processor configured in a manner similar to that used for ambiguity-function generation. The cyclic spectrum can be obtained in a postprocessing step by Fourier transformation of the cyclic correlation in one dimension. Higher-order extensions of the cyclic correlation are also discussed, and it is shown how a two-dimensional slice of the three-dimensional cyclic triple correlation can be computed by use of an acousto-optic four-product processor. RP SADLER, BM (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 19 TC 2 Z9 2 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD AUG 10 PY 1995 VL 34 IS 23 BP 5091 EP 5099 PG 9 WC Optics SC Optics GA RM677 UT WOS:A1995RM67700008 PM 21052354 ER PT J AU GRAY, JMNT MORLAND, LW COLBECK, SC AF GRAY, JMNT MORLAND, LW COLBECK, SC TI THE EFFECT OF CHANGE IN THERMAL-PROPERTIES ON THE PROPAGATION OF A PERIODIC THERMAL-WAVE - APPLICATION TO A SNOW-BURIED ROCKY OUTCROP SO JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH LA English DT Article AB The propagation of a periodic thermal wave into snow is significantly altered by the presense of a shallow rock interface because of the large difference in thermal properties of the two media. The temperature distribution is modeled using classical heat conduction equations subject to a periodic diurnal or seasonal surface heat flux condition, jump conditions at the interface, and insulating conditions in the far-field. The natural length scale (skin depth) over which order unity changes in temperature occur is proportional to the square root of the timescale of the surface temperature variations. If the interface lies close to or within the skin depth then large temperature gradients can be sustained in the snow before temperature oscillations are forced through to the underlying rock. These features are explained by an analytic one-dimensional periodic solution. A numerical algorithm is constructed to solve for the temperature around plane two-dimensional rock geometries. The results show that during a period of atmospheric cooling the presence of a buried rocky outcrop increases the snow temperature and temperature gradients simultaneously to produce very favorable conditions for crystal growth and avalanche formation. C1 UNIV E ANGLIA, SCH MATH, NORWICH NR4 7TJ, NORFOLK, ENGLAND. USA, COLD REG RES & ENGN LAB, HANOVER, NH 03755 USA. RI Gray, John/D-2269-2009 OI Gray, John/0000-0003-3554-0499 NR 18 TC 3 Z9 3 U1 0 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9313 EI 2169-9356 J9 J GEOPHYS RES-SOL EA JI J. Geophys. Res.-Solid Earth PD AUG 10 PY 1995 VL 100 IS B8 BP 15267 EP 15279 DI 10.1029/95JB01241 PG 13 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA RN992 UT WOS:A1995RN99200021 ER PT J AU LITVIN, AL SAMUELSON, LA CHARYCH, DH SPEVAK, W KAPLAN, DL AF LITVIN, AL SAMUELSON, LA CHARYCH, DH SPEVAK, W KAPLAN, DL TI INFLUENCE OF SUPRAMOLECULAR TEMPLATE ORGANIZATION ON MINERALIZATION SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Letter ID STEARIC-ACID MONOLAYERS; STRUCTURAL ASPECTS; RECOGNITION; INTERFACES; CRYSTALS AB The influence of supramolecular diacetylenic template structures on spacial location and morphology of CaCO3 crystals grown under the template has been demonstrated. The periodic modulations in supramolecular template textures (global geometry; millimeter scale) influence crystal location, whereas the local density of the template (local geometry; nanometer scale) influences the polymorph selectivity. For various anionic functional groups under specific experimental conditions, it was found that the binding of Ca ions to the organic template results in an increase of similar to 4.5-5 Angstrom(2)/molecule to the molecular area based on pressure-area isotherms. C1 USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. GEOCENTERS INC,NATICK,MA 01760. UNIV CALIF BERKELEY,LAWRENCE BERKELEY LAB,BERKELEY,CA 94720. NR 29 TC 25 Z9 25 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD AUG 10 PY 1995 VL 99 IS 32 BP 12065 EP 12068 DI 10.1021/j100032a001 PG 4 WC Chemistry, Physical SC Chemistry GA RN706 UT WOS:A1995RN70600001 ER PT J AU PROCHAZKA, K KISEROW, DJ WEBBER, SE AF PROCHAZKA, K KISEROW, DJ WEBBER, SE TI FLUORESCENCE POLARIZATION STUDY OF POLYMER MICELLES SO ACTA POLYMERICA LA English DT Article ID TIME-RESOLVED FLUORESCENCE; BLOCK-COPOLYMER MICELLES; DIBLOCK COPOLYMERS; POLY(METHYL METHACRYLATE); MACROMOLECULAR CHAINS; ROTATIONAL DIFFUSION; DEPOLARIZATION MEASUREMENTS; ANIONIC SYNTHESIS; LIGHT-SCATTERING; ENERGY-TRANSFER C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. UNIV TEXAS,DEPT CHEM & BIOCHEM,AUSTIN,TX 78712. UNIV TEXAS,CTR POLYMER RES,AUSTIN,TX 78712. RP PROCHAZKA, K (reprint author), CHARLES UNIV,FAC SCI,DEPT CHEM PHYS,CR-12843 PRAGUE 2,CZECH REPUBLIC. RI Prochazka, Karel/C-3012-2014 OI Prochazka, Karel/0000-0003-2144-5378 NR 78 TC 19 Z9 19 U1 0 U2 2 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0323-7648 J9 ACTA POLYM JI Acta Polym. PD AUG PY 1995 VL 46 IS 4 BP 277 EP 290 DI 10.1002/actp.1995.010460401 PG 14 WC Polymer Science SC Polymer Science GA RR373 UT WOS:A1995RR37300001 ER PT J AU DSOUZA, MP MILMAN, G BRADAC, JA MCPHEE, D HANSON, CV HENDRY, RM CORCORAN, T STOTT, J FUNG, M HANSON, C LAMAN, J MASCOLA, J MCPHEE, D RASHEED, S RICHMAN, D SCHUITEMAKER, H THIRIART, C WAINBERG, M WEBER, J BEDDOWS, S TILLEY, S ROBINSON, J ZOLLAPAZNER, S KATINGER, H CUMMINS, L AF DSOUZA, MP MILMAN, G BRADAC, JA MCPHEE, D HANSON, CV HENDRY, RM CORCORAN, T STOTT, J FUNG, M HANSON, C LAMAN, J MASCOLA, J MCPHEE, D RASHEED, S RICHMAN, D SCHUITEMAKER, H THIRIART, C WAINBERG, M WEBER, J BEDDOWS, S TILLEY, S ROBINSON, J ZOLLAPAZNER, S KATINGER, H CUMMINS, L TI NEUTRALIZATION OF PRIMARY HIV-1 ISOLATES BY ANTI-ENVELOPE MONOCLONAL-ANTIBODIES SO AIDS LA English DT Article DE MONOCLONAL ANTIBODIES; PRIMARY ISOLATES; NEUTRALIZATION ASSAYS ID HUMAN-IMMUNODEFICIENCY-VIRUS; GLYCOPROTEIN GP120; SURFACE GLYCOPROTEIN; CD4 BINDING; SOLUBLE CD4; TYPE-1; INFECTION; CHIMPANZEES; PROTECTION; CHALLENGE AB Objective: To evaluate human monoclonal antibodies (MAb) for neutralizing activity against primary HIV-1 isolates in peripheral blood mononuclear cells. Design: Neutralization activity data were obtained from 11 laboratories on a coded panel consisting of six human MAb to HIV envelope V3, CD4-binding region or gp41. Hyperimmune globulin against HIV-1 and normal human immunoglobulin G were supplied as controls. Each laboratory received pre-titered virus for use in the studies. Methods: Each laboratory measured neutralization of the MAb against laboratory strain HIVMN, genomic clone HIVJR-CSF, two subtype B and one subtype D primary isolates. Results: The titers of the centrally supplied virus stocks as determined by re-titration or back-titration varied among laboratories and were generally 10-100-fold less than provided. The neutralizing activity of each MAb varied by as much as a 1000-fold among laboratories. These differences may result from varying sensitivity in neutralization assay protocols and the differing susceptibility of primary cells to infection with HIV-1. Conclusions: To consolidate the data from multiple laboratories, the neutralization titers were compared by classifying antibodies as neutralizing if the antibody concentration for 50% virus inhibition was less than or equal to 10 mu g/ml. By this criterion, the CD4-binding region and gp41 MAb neutralized all four subtype B viruses and the subtype D isolate in a few of the laboratories. The V3 MAb neutralized only HIVMN and the closely related HIVJR-CSF viruses. C1 MACFARLANE BURNET CTR MED RES,NATL CTR HIV VIROL RES,FAIRFIELD,VIC,AUSTRALIA. CALIF DEPT HLTH SERV,VIRAL & RICKETTSIAL LAB,BERKELEY,CA. NATL INST BIOL STAND & CONTROLS,LAB A,LONDON,ENGLAND. TANOX BIOSYST INC,LAB B,HOUSTON,TX 77025. CALIF DEPT HLTH SERV,LAB C,SACRAMENTO,CA 95814. TNO,MED BIOL LAB,THE HAGUE,NETHERLANDS. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,LAB E,WASHINGTON,DC 20307. UNIV SO CALIF,LAB G,LOS ANGELES,CA 90089. UNIV CALIF SAN DIEGO,LAB H,LA JOLLA,CA 92093. NETHERLANDS RED CROSS,LAB I,AMSTERDAM,NETHERLANDS. SMITHKLINE BEECHAM BIOL,LAB J,RIXENSART,BELGIUM. MCGILL AIDS CTR,LAB K,MONTREAL,PQ,CANADA. ST MARYS HOSP,LAB L,LONDON,ENGLAND. PUBL HLTH RES INST,NEW YORK,NY 10016. UNIV CONNECTICUT,STORRS,CT 06268. NYU,MED CTR,NEW YORK,NY 10016. AGR UNIV VIENNA,VIENNA,AUSTRIA. N AMER BIOL INC,MIAMI,FL 33269. RP DSOUZA, MP (reprint author), NIAID,DIV AIDS,PATHOGENESIS & BASIC RES BRANCH,6003 EXECUT BLVD,SOLAR BLDG,ROOM 2C35,BETHESDA,MD 20892, USA. NR 45 TC 48 Z9 48 U1 0 U2 2 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0269-9370 J9 AIDS JI Aids PD AUG PY 1995 VL 9 IS 8 BP 867 EP 874 DI 10.1097/00002030-199508000-00006 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA RN991 UT WOS:A1995RN99100006 PM 7576320 ER PT J AU FRANCHINI, G ROBERTGUROFF, M TARTAGLIA, J AGGARWAL, A ABIMIKU, A BENSON, J MARKHAM, P LIMBACH, K HURTEAU, G FULLEN, J ALDRICH, K MILLER, N SADOFF, J PAOLETTI, E GALLO, RC AF FRANCHINI, G ROBERTGUROFF, M TARTAGLIA, J AGGARWAL, A ABIMIKU, A BENSON, J MARKHAM, P LIMBACH, K HURTEAU, G FULLEN, J ALDRICH, K MILLER, N SADOFF, J PAOLETTI, E GALLO, RC TI HIGHLY ATTENUATED HIV TYPE-2 RECOMBINANT POXVIRUSES, BUT NOT HIV-2 RECOMBINANT SALMONELLA VACCINES, INDUCE LONG-LASTING PROTECTION IN RHESUS MACAQUES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID SIMIAN IMMUNODEFICIENCY VIRUS; TOXIC LYMPHOCYTES-T; CONFERS PROTECTION; CYNOMOLGUS MONKEYS; CYTOTOXIC LYMPHOCYTES; SYNTHETIC PEPTIDES; EXPRESSION VECTOR; ORAL SALMONELLA; SIV INFECTION; ENVELOPE AB Immunization schemes employing priming with vector-based vaccine candidates followed by subunit booster administrations have been explored and shown to have merit in the human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus systems, In this study, we have assessed the priming capacity of highly attenuated poxvirus vector (NYVAC and ALVAC)-based HIV-2 recombinants, as well as Salmonella typhimurium HIV-2 recombinants in rhesus macaques, ALVAC- and NYVAC-based vaccine candidates expressing the HIV-2 gag, pol, and env genes or NYVAC-based recombinants expressing either gp160 or gp120 were used to immunize rhesus macaques in combination protocols with alum-adjuvanted HIV-2 rgp160, Following intravenous challenge exposure with 100 infectious doses of the HIV-2(SBL6669) parental virus genotype mixture, seven of eight animals were protected from infection. The seven protected animals were rechallenged 6 months postprimary challenge, without additional booster inoculations, with the same dose of the HIV-2(SBL6669) parental virus. Five of the seven animals remained protected against HIV-2 infection at 6 months following the second challenge. In contrast, oral immunization with recombinant Salmonella expressing the HIV-2 gag and the gp120 portion of the envelope either alone or in combination with alum-adjuvanted rgp160 failed to confer protection. These results suggest that the NYVAC- and ALVAC-based recombinants may confer long-lasting protection and that these two highly attenuated poxvirus vaccine vectors may represent promising candidates for developing an acquired immunodeficiency syndrome vaccine. C1 VIROGENET CORP,TROY,NY 12180. ADV BIOSCI LABS,KENSINGTON,MD 20895. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP FRANCHINI, G (reprint author), NCI,TUMOR CELL BIOL LAB,BLDG 37,ROOM 6A11,37 CONVENT DR,BETHESDA,MD 20892, USA. NR 60 TC 55 Z9 55 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1995 VL 11 IS 8 BP 909 EP 920 DI 10.1089/aid.1995.11.909 PG 12 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA RN993 UT WOS:A1995RN99300005 PM 7492438 ER PT J AU SMITH, KJ SKELTON, HG RUIZ, N LASKIN, W WAGNER, KF AF SMITH, KJ SKELTON, HG RUIZ, N LASKIN, W WAGNER, KF TI MALIGNANT-LYMPHOMA OF SOFT-TISSUE IN AN HIV-1+ PATIENT - A RARE SITE FOR PRIMARY MALIGNANT-LYMPHOMA WITH IMPLICATIONS FOR TREATMENT SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Note DE MALIGNANT LYMPHOMA; SOFT TISSUE LYMPHOMA; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1. ID ACQUIRED IMMUNODEFICIENCY SYNDROME; NON-HODGKINS-LYMPHOMA; SYNDROME AIDS AB Soft tissue lymphomas are rare; however, the only large reported series has indicated that soft tissue lymphomas may have a better prognosis than similar-grade tumors found at other sites, and even high-grade lesions may respond to local therapies, We present a human immunodeficiency virus type 1 (HIV-1)-positive, Waiter Reed stage VI black male with a documented high-grade soft tissue non-Hodgkin's lymphoma with no other evidence of tumor on complete systemic evaluation. Although extranodal lymphomas are common in HIV-1 disease, we are aware of no other reports of a soft tissue lymphoma in an HIV-1-positive patient. A significant percentage of soft tissue lymphomas in the general population, even when they are high grade, responds to local therapies including surgical excision and radiation. Thus, confirmation of this diagnosis in HIV-1 disease may be important, because these patients frequently develop fatal opportunistic infections and tolerate chemotherapy poorly, especially in late stages of disease. C1 WALTER REED ARMY INST RES, WASHINGTON, DC 20306 USA. NATL NAVAL MED CTR, WASHINGTON, DC USA. HENRY M JACKSON FDN, WASHINGTON, DC USA. RP SMITH, KJ (reprint author), ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20306 USA. NR 9 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD AUG PY 1995 VL 17 IS 4 BP 403 EP 406 PG 4 WC Dermatology SC Dermatology GA RM670 UT WOS:A1995RM67000018 PM 8600808 ER PT J AU RUOCCO, MJ ROBLES, HA RAO, KCVG ARMONDA, RA ONDRA, SL AF RUOCCO, MJ ROBLES, HA RAO, KCVG ARMONDA, RA ONDRA, SL TI INTRATENTORIAL LIPOMAS WITH MECKELS CAVE AND CEREBELLOPONTINE ANGLE EXTENSION SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article DE LIPOMA; TENTORIUM; BRAIN, NEOPLASMS ID MR AB An unusual case of bilateral intratentorial lipomas with extension into Meckel's caves and the cerebellopontine angle is described. Surgical and histopathologic correlation demonstrate that the lipoma encased the trigeminal nerve in Meckel's caves, The origin of the lipoma from the anteromedial margins of the tentorium is discussed and correlated with a recently proposed theory for the development of intracranial lipomas. C1 WALTER REED ARMY MED CTR,DEPT NEUROSURG,WASHINGTON,DC 20307. RP RUOCCO, MJ (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307, USA. NR 7 TC 6 Z9 7 U1 0 U2 0 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD AUG PY 1995 VL 16 IS 7 BP 1504 EP 1506 PG 3 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA RP617 UT WOS:A1995RP61700024 PM 7484642 ER PT J AU HARPER, DL AF HARPER, DL TI A CASE-REPORT OF A BRODIE BITE SO AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS LA English DT Note C1 USA,DEPT ORTHODONT,FT BRAGG,NC. USA,ADV EDUC GEN DENT 2 YEAR PROGRAM,FT BRAGG,NC. NR 10 TC 9 Z9 10 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0889-5406 J9 AM J ORTHOD DENTOFAC JI Am. J. Orthod. Dentofac. Orthop. PD AUG PY 1995 VL 108 IS 2 BP 201 EP 206 DI 10.1016/S0889-5406(95)70084-6 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA RN892 UT WOS:A1995RN89200018 PM 7625396 ER PT J AU GAERTNER, EM DAVIDSON, M WENIG, BM AF GAERTNER, EM DAVIDSON, M WENIG, BM TI THE COLUMNAR CELL VARIANT OF THYROID PAPILLARY CARCINOMA - CASE-REPORT AND DISCUSSION OF AN UNUSUALLY AGGRESSIVE THYROID PAPILLARY CARCINOMA SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Note DE THYROID GLAND; THYROID PAPILLARY CARCINOMA; COLUMNAR CELL VARIANT, FEMALE; IMMUNOHISTOCHEMISTRY AB The columnar cell variant of thyroid papillary carcinoma is an aggressive tumor associated with widespread dissemination and a fatal outcome. We report a case of a 29-year-old white woman who presented with a large thyroid mass extending into the mediastinum with local and distant metastases. The histologic features included focal papillary growth with columnar cells and nuclear stratification. However, the histologic picture was dominated by cells with a clear to vacuolated-appearing cytoplasm similar to that seen in association with secretory-type endometrium. In addition, areas of solid growth and organoid or glandular features were also identified. This tumor followed an aggressive course with widespread metastatic disease unresponsive to all therapeutic intervention. The patient died 7 months after diagnosis. We believe this tumor represents the columnar cell variant of thyroid papillary carcinoma. This is only the second reported case of columnar cell carcinoma to occur in a female. Other than the unusual occurrence in a woman, the clinical and pathologic features of this case are similar to those previously reported, including an aggressive behavior followed rapidly by the death of the patient. C1 ARMED FORCES INST PATHOL,DEPT OTOLARYNG & ENDOCRINE PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC. NR 15 TC 28 Z9 30 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD AUG PY 1995 VL 19 IS 8 BP 940 EP 947 DI 10.1097/00000478-199508000-00010 PG 8 WC Pathology; Surgery SC Pathology; Surgery GA RK518 UT WOS:A1995RK51800010 PM 7611541 ER PT J AU NIKLASSON, B HORNFELDT, B LUNDKVIST, A BJORSTEN, S LEDUC, J AF NIKLASSON, B HORNFELDT, B LUNDKVIST, A BJORSTEN, S LEDUC, J TI TEMPORAL DYNAMICS OF PUUMALA VIRUS-ANTIBODY PREVALENCE IN VOLES AND OF NEPHROPATHIA-EPIDEMICA INCIDENCE IN HUMANS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HEMORRHAGIC-FEVER; RENAL SYNDROME; CLETHRIONOMYS-GLAREOLUS; PLANT-PRODUCTION; ETIOLOGIC AGENT; NORTHERN SWEDEN; SMALL GAME; POPULATION; INFECTION; CYCLES AB Puumala (PUU) virus is the etiologic agent of nephropathia epidemica (NE) in humans. This disease is highly endemic in Vasterbotten county, Sweden, with an annual incidence of 19.2 (range 3.7-37.4) per 100,000 inhabitants. Voles are considered to be both the main reservoir and the vector of PUU virus. A total of 3,591 rodents (mainly Clethrionomys glareolus, C. rufocanus, and Microtus agrestis) trapped in Vasterbotten between 1979 and 1987 were tested for the presence of PUU virus antibodies by enzyme-linked immunosorbent assay. The predominant species, C. glareolus (71% [2,544 of 3,591]), also had the highest antibody prevalence (19% [483 of 2,544]). In C. glareolus, the antibody prevalence rate increased with weight (age), reaching more than 50% in the heaviest weight group, and suggesting that horizontal infection may be important. The highest frequency (25%) of antibody-positive C. rufocanus was also found in the highest weight groups. Microtus agrestis showed low absolute numbers and a low antibody prevalence rate (5%). In C. glareolus, both antibody prevalence and weight were recurrently higher in the spring than in the previous fall. The antibody prevalence rate in spring was positively correlated with the vole density in the previous fall and spring. The fall antibody prevalence rate was directly dependent on C. glareolus density. The incidence of human NE in the fall was dependent on the concurrent density of C. glareolus, whereas the incidence of NE in the spring was dependent on vole density the previous fall. C1 UMEA UNIV,DEPT ANIM ECOL,S-90187 UMEA,SWEDEN. ABC,FOA,NATL DEF RES ESTAB,S-90182 UMEA,SWEDEN. USA,MED RES INST INFECT DIS,FREDERICK,MD. RP NIKLASSON, B (reprint author), SWEDISH INST INFECT DIS CONTROL,DEPT DEF MICROBIOL,S-10521 STOCKHOLM,SWEDEN. NR 30 TC 112 Z9 115 U1 2 U2 12 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 1995 VL 53 IS 2 BP 134 EP 140 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA RV154 UT WOS:A1995RV15400004 PM 7677213 ER PT J AU GENOVESE, RF PETRAS, JM BREWER, TG AF GENOVESE, RF PETRAS, JM BREWER, TG TI ARTEETHER NEUROTOXICITY IN THE ABSENCE OF DEFICITS IN BEHAVIORAL PERFORMANCE IN RATS SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Note ID PHYSOSTIGMINE; SCOPOLAMINE C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP GENOVESE, RF (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 11 TC 28 Z9 28 U1 0 U2 1 PU W B SAUNDERS CO LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD AUG PY 1995 VL 89 IS 4 BP 447 EP 449 PG 3 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA RV368 UT WOS:A1995RV36800012 PM 7487233 ER PT J AU ZVILICH, M WILLIAMS, JC WAAG, D RILL, WR MALLI, RJ BELL, P KENDE, M AF ZVILICH, M WILLIAMS, JC WAAG, D RILL, WR MALLI, RJ BELL, P KENDE, M TI CHARACTERIZATION OF THE NONSPECIFIC HUMORAL AND CELLULAR ANTIVIRAL IMMUNITY STIMULATED BY THE CHLOROFORM-METHANOL RESIDUE (CMR) FRACTION OF COXIELLA-BURNETII SO ANTIVIRAL RESEARCH LA English DT Article DE COXIELLA BURNETII; CHLOROFORM METHANOL RESIDUE; IMMUNOMODULATOR; RIFT VALLEY FEVER VIRUS ID PHASE-I; Q-FEVER; SCN MICE; IMMUNOGENICITY; INTERLEUKIN-1; INFECTIONS; VACCINES; THERAPY; SILICA; CELLS AB Modulation of the immune response by the chloroform-methanol residue (CMR) of phase I Coxiella burnetii whole cell was studied in Rift Valley fever virus-infected, or in naive endotoxin-non-responder C3H/HeJ mice. A single dose of CMR completely protected the mice from viral infection. Treating virus-infected mice with antibodies directed against interferons alpha/beta (IFN-alpha beta) and gamma (IFN-gamma) eliminated the CMR-induced protection. CMR stimulated the production of high levels of IFN-alpha/beta and 2'-5'-oligoadenylate synthetase activities in sera of the CMR-treated mice. IFN-gamma was present in supernatants of cultured spleen cells of CMR-treated, virus-infected mice, but not in their serum. Priming mice with CMR optimized the release of INF-gamma, interleukin-1 alpha (IL-1 alpha) and IL-6 from splenocytes in vitro. When stimulated in vitro, IL-2 and granulocyte-macrophage stimulating factor (GM-CSF) did not require in vivo priming for release from cultured spleen cells. Fluorescence-assisted cytometry of CMR-treated mouse spleen cells showed there was a CMR-dependent increase in the percentage of T-cells and Ia-positive T-cells. There also was a biphasic increase in the ratio between T-h (L3T4) and T-s (Lyt2) cells. Biological activities stimulated by CMR indicate that CMR is a potent immunostimulant, which may modulate specific and non-specific antiviral responses. C1 USA,MED RES INST INFECT DIS,DEPT CLIN IMMUNOL,DIV APPL RES,FT DETRICK,MD 21702. USA,MED RES INST INFECT DIS,DEPT PATHOGENESIS & IMMUNOL,DIV BACTERIOL,FT DETRICK,MD 21702. US FDA,CTR BIOL EVALUAT & RES,DIV VACCINES & RELATED PROD APPLICAT,OFF VACCINE RES & REVIEW,ROCKVILLE,MD 20852. NR 28 TC 4 Z9 4 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD AUG PY 1995 VL 27 IS 4 BP 389 EP 404 DI 10.1016/0166-3542(95)00022-E PG 16 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA RQ383 UT WOS:A1995RQ38300006 PM 8540758 ER PT J AU SLINEY, DH FAST, P RICKSAND, A AF SLINEY, DH FAST, P RICKSAND, A TI OPTICAL RADIATION HAZARDS ANALYSIS OF ULTRAVIOLET HEADLAMPS SO APPLIED OPTICS LA English DT Article DE ULTRAVIOLET; EYE; HAZARDS; HEADLAMPS ID DAMAGE; LIGHT AB The potential hazards to the eye and skin associated with the use of UV-emitting automotive headlamps are considered. Wide-scale use of high-beam, near-UV headlamps to permit viewing of fluorescence in clothes and fluorescent road markers at great distances can increase automotive safety; however, the potential hazards from exposure of persons to UV radiation must be evaluated. From the study we conclude that such headlamps can be safely designed to preclude human exposure to potentially hazardous levels of UV radiation. C1 ULTRALUX AB,S-40508 GOTHENBURG,SWEDEN. RP SLINEY, DH (reprint author), USA,ENVIRONM HYG AGCY,ABERDEEN PROVING GROUND,MD 21010, USA. NR 43 TC 9 Z9 9 U1 1 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD AUG 1 PY 1995 VL 34 IS 22 BP 4912 EP 4922 PG 11 WC Optics SC Optics GA RL484 UT WOS:A1995RL48400039 PM 21052333 ER PT J AU KRIVDA, SJ BEARD, JS KOVACH, JA JAMES, WD AF KRIVDA, SJ BEARD, JS KOVACH, JA JAMES, WD TI CUTANEOUS ULCERATION AND A NEW CARDIAC MURMUR IN A YOUNG WOMAN SO ARCHIVES OF DERMATOLOGY LA English DT Article ID PRIMARY ANTIPHOSPHOLIPID SYNDROME; SYSTEMIC LUPUS-ERYTHEMATOSUS; DISEASE RP KRIVDA, SJ (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD AUG PY 1995 VL 131 IS 8 BP 897 EP 899 PG 3 WC Dermatology SC Dermatology GA RN897 UT WOS:A1995RN89700004 PM 7632060 ER PT J AU ARCIERO, RA TAYLOR, DC SNYDER, RJ UHORCHAK, JM AF ARCIERO, RA TAYLOR, DC SNYDER, RJ UHORCHAK, JM TI ARTHROSCOPIC BIOABSORBABLE TACK STABILIZATION OF INITIAL ANTERIOR SHOULDER DISLOCATIONS - A PRELIMINARY-REPORT SO ARTHROSCOPY LA English DT Article DE ARTHROSCOPIC BANKART REPAIR; ACUTE INITIAL SHOULDER DISLOCATION; BIOABSORBABLE FIXATION DEVICE AB Twenty-six consecutive cadet athletes sustained an acute, initial anterior shoulder dislocation. All dislocations required a manual reduction for initial treatment. Arthroscopy was performed within 10 days in all patients. The Beach chair position and interscalene anesthesia were used in each case. At arthroscopy, 25 patients had an avulsion of the anterior-inferior capsulolabral complex (Bankart lesion) from the glenoid rim. One patient had a lateral detachment of the inferior glenohumeral ligament from the humeral neck. Twenty-three patients had a Hill-Sachs lesion and 3 SLAP tears were noted. All Bankart lesions were repaired with a cannulated bioabsorbable fixation device. Nineteen patients, over 1 year postoperative, are the subject of this preliminary report. The average age was 19.5 years (range, 17 to 23 years). Follow-up averaged 19 months (range, 12 to 24 months). The average loss of external rotation was 3 degrees. There have been no recurrent dislocations and 1 patient has had a single episode of resubluxation. Using the Rowe point score, 16 patients were rated excellent, 2 good, and 1 fair. All of the athletes in this study have returned to preinjury performance status. Acute stabilization of initial anterior shoulder dislocations appears to be an effective treatment option in young athletes known to have high recurrence rates with nonoperative treatment. This particular technique has been safe with little morbidity. RP ARCIERO, RA (reprint author), US MIL ACAD,KELLER ARMY HOSP,ORTHOPAED SERV,W POINT,NY 10996, USA. NR 0 TC 90 Z9 93 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0749-8063 J9 ARTHROSCOPY JI Arthroscopy PD AUG PY 1995 VL 11 IS 4 BP 410 EP 417 DI 10.1016/0749-8063(95)90192-2 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA RY835 UT WOS:A1995RY83500006 PM 7575872 ER PT J AU WITKIN, JM STEELE, TD GETERDOUGLASS, B TORTELLA, FC AF WITKIN, JM STEELE, TD GETERDOUGLASS, B TORTELLA, FC TI PRECLINICAL PHARMACOLOGY OF LIGANDS ACTING AT THE STRYCHNINE-INSENSITIVE GLYCINE RECEPTOR OF THE NMDA RECEPTOR SO BEHAVIOURAL PHARMACOLOGY LA English DT Meeting Abstract C1 NIDA,ADDICT RES CTR,BALTIMORE,MD 21224. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0955-8810 J9 BEHAV PHARMACOL JI Behav. Pharmacol. PD AUG PY 1995 VL 6 IS 5-6 BP 636 EP 636 DI 10.1097/00008877-199508000-00088 PG 1 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA RW098 UT WOS:A1995RW09800086 ER PT J AU ALDRIDGE, DW PAYNE, BS MILLER, AC AF ALDRIDGE, DW PAYNE, BS MILLER, AC TI OXYGEN-CONSUMPTION, NITROGENOUS EXCRETION, AND FILTRATION-RATES OF DREISSENA-POLYMORPHA AT ACCLIMATION TEMPERATURES BETWEEN 20 AND 32-DEGREES-C SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES LA English DT Article ID ZEBRA MUSSEL; NATIVE BIVALVES; GREAT-LAKES; BIOENERGETICS; RESPONSES AB Mussels were acclimated to each of four experimental temperatures (20, 24, 28, and 32 degrees C) for 30 days. Mussels averaged 10.29 mg tissue dry weight. Oxygen consumption rates at 32 degrees C were 3.65 times larger than consumption rates at 20 degrees C (p < 0.01). Ammonia excretion rates at 32 degrees C were 4.9 times greater than those at 20 degrees C (p < 0.01). O:N ratios were > 60 at 20 and 24 degrees C but declined (p < 0.01) at 28 and 32 degrees C to < 40. Filtration rates, an estimate of feeding rates, were not significantly different at 20 and 24 degrees C (p > 0.50) but declined at 28 and 32 degrees C (p < 0.01). Filtration rates at 32 degrees C were only 27% of the rates at 20 degrees C. These results indicate that (i) the metabolic expenditure of Dreissena polymorpha rose 265% as the temperature rose from 20 to 32 degrees C, (ii) metabolism relied more heavily on lipids and carbohydrates at 20 and 24 degrees C while protein catabolism increased at 28 and 32 degrees C, and (iii) the potential feeding rates of D. polymorpha declined by 73% as temperature rose from 20 to 32 degrees C. Above 28 degrees C D. polymorpha was unable to match energy expenditures with concurrent food intake and forced to rely on stored fuels. C1 USA,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP ALDRIDGE, DW (reprint author), N CAROLINA AGR & TECH STATE UNIV,DEPT BIOL,GREENSBORO,NC 27411, USA. NR 39 TC 53 Z9 68 U1 0 U2 17 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0706-652X J9 CAN J FISH AQUAT SCI JI Can. J. Fish. Aquat. Sci. PD AUG PY 1995 VL 52 IS 8 BP 1761 EP 1767 DI 10.1139/f95-768 PG 7 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA TE924 UT WOS:A1995TE92400016 ER PT J AU DAWSON, NA COOPER, MR FIGG, WD HEADLEE, DJ THIBAULT, A BERGAN, RC STEINBERG, SM SAUSVILLE, EA MYERS, CE SARTOR, O AF DAWSON, NA COOPER, MR FIGG, WD HEADLEE, DJ THIBAULT, A BERGAN, RC STEINBERG, SM SAUSVILLE, EA MYERS, CE SARTOR, O TI ANTITUMOR-ACTIVITY OF SURAMIN IN HORMONE-REFRACTORY PROSTATE-CANCER CONTROLLING FOR HYDROCORTISONE TREATMENT AND FLUTAMIDE WITHDRAWAL AS POTENTIALLY CONFOUNDING VARIABLES SO CANCER LA English DT Article DE PROSTATIC NEOPLASMS; SURAMIN; HYDROCORTISONE; FLUTAMIDE; PROSTATE SPECIFIC ANTIGEN ID GROWTH-FACTOR RECEPTOR; ADAPTIVE-CONTROL; CELLS; INHIBITION; CARCINOMA; FEEDBACK; DISEASE; ANTIGEN; DRUG AB Background. A prospective Phase II clinical trial was conducted to assess the clinical activity of a pharmacokinetically guided suramin regimen in patients who had documented progression of metastatic prostate cancer after hydrocortisone plus antecedent or simultaneous withdrawal of flutamide. Methods. Fifty-four patients whose disease had progressed after castration and flutamide administration were enrolled on this trial. The study was divided into two parts. Initially, 52 patients received hydrocortisone (30 mg/day) and for those patients receiving flutamide, at study entry (34 patients) flutamide was simultaneously discontinued. Forty-three patients whose disease progressed on hydrocortisone received suramin for 6-8 weeks. Six patients who progressed on hydrocortisone became ineligible for suramin due to clinical deterioration, four patients are still responding to hydrocortisone at more than 1 year, and one patient elected to postpone initiation of suramin. Suramin was given as intermittent infusions at fixed doses on days 1-5 and thereafter dosing was guided by adaptive control with feedback to maintain plasma suramin concentrations between 300-175 mu g/ml, Antitumor activity was assessed by prostate specific antigen (PSA) decline and soft-tissue disease response. Results. Ten patients (19%; 95% CI, 9.6%-32.5%) responded to hydrocortisone therapy with either a 50% or greater PSA decline for at least 4 weeks (9 patients) and/or a partial response of measurable soft-tissue disease (2 patients). Five of these patients (10%) demonstrated a 80% or greater PSA decline. All responders to hydrocortisone had simultaneous flutamide withdrawal, and had been receiving flutamide as part of initial combined androgen blockade. Seven of 37 evaluable patients (19%; 95% CI, 8.0%-35.2%) responded to suramin with a 50% or greater decline in PSA for 4 weeks or longer. One patient (3%) had a 80% or greater decline in PSA, There were no soft-tissue disease responses to suramin, The median time to progression was 1.9 months for hydrocortisone therapy and 2.6 months for suramin therapy. The median survival for all patients was 14.6 months. Conclusion. Suramin has antitumor activity in metastatic prostate carcinoma independent of the therapeutic effect of hydrocortisone administration or flutamide withdrawal. The role of prior flutamide withdrawal and hydrocortisone replacement should be taken into account in future studies of suramin. C1 NCI,BIOSTAT & DATA MANAGEMENT SECT,CLIN PHARMACOL BRANCH,BETHESDA,MD 20892. NCI,CLIN ONCOL PROGRAM,BETHESDA,MD 20892. NCI,DIV CANC TREATMENT,BIOL CHEM LAB,BETHESDA,MD 20892. RP DAWSON, NA (reprint author), WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. RI Figg Sr, William/M-2411-2016 NR 43 TC 56 Z9 58 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD AUG 1 PY 1995 VL 76 IS 3 BP 453 EP 462 DI 10.1002/1097-0142(19950801)76:3<453::AID-CNCR2820760316>3.0.CO;2-E PG 10 WC Oncology SC Oncology GA RK630 UT WOS:A1995RK63000015 PM 8625127 ER PT J AU ARGYROS, GJ ROACH, JM HURWITZ, KM ELIASSON, AH PHILLIPS, YY AF ARGYROS, GJ ROACH, JM HURWITZ, KM ELIASSON, AH PHILLIPS, YY TI THE REFRACTORY PERIOD AFTER EUCAPNIC VOLUNTARY HYPERVENTILATION CHALLENGE AND ITS EFFECT ON CHALLENGE TECHNIQUE SO CHEST LA English DT Article DE ASTHMA; EXERCISE-INDUCED ASTHMA; HYPERVENTILATION-INDUCED ASTHMA; MECHANISMS; REFRACTORY PERIOD; RESPIRATORY WATER LOSS ID EXERCISE-INDUCED ASTHMA; COLD AIR CHALLENGE; ISOCAPNIC HYPERVENTILATION; BRONCHOPROVOCATION CHALLENGE; INDUCED BRONCHOSPASM; BRONCHIAL CHALLENGE; WATER-LOSS; HEAT-FLUX; STIMULUS; BRONCHOCONSTRICTION AB To evaluate whether there is a refractory period (RP) after hyperventilation challenge, we compared the bronchoconstrictive response to repetitive eucapnic voluntary hyperventilation challenge with dry, room temperature air (EVH). The serial challenges were identical with 11 known asthmatics hyperventilating for 6 min at a target minute ventilation of 30 times their FEV(1) measured before either challenge. There was a significant difference between the mean postchallenge fall in FEV(1) to the initial EVH challenge (27.4+/-9.8%) and the response to the second EVH challenge (16.1+/-5.9%) (p=0.0001), indicating refractoriness. We then evaluated whether 6 min of uninterrupted EVH challenge gives a similar bronchospastic response to that which results from an equivalent (by total minute ventilation) interrupted challenge of 2 min of EVH repeated three times. The mean postchallenge fall in FEV(1) in response to this interrupted challenge was 18.9+/-10.6%, which was significantly different from the 27.4% fall in response to 6 consecutive minutes of EVH (p=0.036). This study demonstrates that there is a refractory period after repeated EVH challenges and this refractoriness affects the response to interrupted, or dosed, EVH challenge. C1 WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 42 TC 21 Z9 21 U1 1 U2 3 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD AUG PY 1995 VL 108 IS 2 BP 419 EP 424 DI 10.1378/chest.108.2.419 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA RN842 UT WOS:A1995RN84200027 PM 7634878 ER PT J AU ELSMORE, TF HEGGE, FW NAITOH, P KELLY, T RYMAN, D AF ELSMORE, TF HEGGE, FW NAITOH, P KELLY, T RYMAN, D TI WINCD - WINDOWS SOFTWARE FOR COMPLEX DEMODULATION SO CHRONOBIOLOGY INTERNATIONAL LA English DT Article DE COMPLEX DEMODULATION; TIME SERIES ANALYSIS; CIRCADIAN RHYTHMS; ULTRADIAN RHYTHMS AB We describe WinCD, a program for extracting quantitative information about periodicity in time-series data using the method of complex demodulation (CD). The method is particularly well suited for the analysis of the effects of variables that may produce changes in biological rhythms, such as sleep deprivation, adaptation to changes in work schedules, time zone displacements, and various sorts of pathology. WinCD enables exploratory analysis of time series data by providing graphical displays of raw and processed time series, as well as numerous options for viewing and saving quantitative data. We describe WinCD operations and examples of the use of the program. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. USN,HLTH RES CTR,SAN DIEGO,CA 92152. NR 12 TC 4 Z9 4 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0742-0528 J9 CHRONOBIOL INT JI Chronobiol. Int. PD AUG PY 1995 VL 12 IS 4 BP 248 EP 256 DI 10.3109/07420529509057273 PG 9 WC Biology; Physiology SC Life Sciences & Biomedicine - Other Topics; Physiology GA RZ401 UT WOS:A1995RZ40100003 ER PT J AU ATWA, MA LUKES, YD SALATA, K ABOHASHEM, EM ELKANNISHY, MH BURMAN, KD AF ATWA, MA LUKES, YD SALATA, K ABOHASHEM, EM ELKANNISHY, MH BURMAN, KD TI THE INFLUENCE OF TRIIODOTHYRONINE, THYROXINE, THYROTROPIN, AND METHIMAZOLE ON THYROID-CELL MHC CLASS-II ANTIGEN EXPRESSION SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Note ID HLA-DR EXPRESSION; GRAVES-DISEASE; ANTITHYROID DRUGS; AUTOIMMUNITY; CARBIMAZOLE; THYROCYTES; INHIBITION; RECURRENCE; RELEVANCE; INDUCTION AB We have studied the influence of triiodothyronine (T-3), thyroxine (T-4), thyrotropin (TSH), and methimazole (MMI) on the expression of major histocompatibility (MHC) Class II antigen expression in human thyroid cells, T-3, T-4, TSH, and MMI in various combinations were added together with interferon-gamma (IFN-gamma) to human thyrocytes or to cultured FRTL-B cells, Neither T-3 nor T-4, alone, caused inhibition of the IFN-gamma stimulation of thyrocyte HLA-DR expression. Moreover, the combination of both drugs at various concentrations did not inhibit this expression except only in low ranges (T-3 at 0.3 nmol/liter and T-4 at 12.9 nmol/liter). MMI only at a concentration of 3.0 mmol/liter caused significant inhibition of IFN-gamma-induced HLA-DR expression, However, the addition of T-3 (range, 0.3-9.2 nmol/liter) or T-4 (12.9-129.0 nmol/liter) prevented the MMI-induced inhibition. This phenomenon may be explained by the action of MMI on inhibiting the synthesis of T-3 and T-4. At a concentration of 100 mu U/ml, TSH enhanced IFN-gamma-induced HLA-DR expression. It is possible that TSH induced the expression of large numbers of IFN-gamma receptors, thereby enhancing the production of HLA-DR in response to IFN-gamma. Our studies suggest that MMI does not alter thyrocyte HLA-DR expression in vitro, especially when combined with T-3 or T-4; however, MMI may still induce or perpetuate immune effects in vivo secondary to its influence on thyroid hormone production or thyroid antigen presentation. (C) 1995 Academic Press, Inc. C1 WALTER REED ARMY MED CTR,DEPT MED,ENDOCRINE METAB SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. MANSOURA UNIV,DEPT CLIN PATHOL,MANSOURA,EGYPT. NR 25 TC 8 Z9 9 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD AUG PY 1995 VL 76 IS 2 BP 209 EP 213 DI 10.1006/clin.1995.1117 PG 5 WC Immunology; Pathology SC Immunology; Pathology GA RJ459 UT WOS:A1995RJ45900015 PM 7614740 ER PT J AU WONG, MT DOLAN, MJ LATTUADA, CP REGNERY, RL GARCIA, ML MOKULIS, EC LABARRE, RC ASCHER, DP DELMAR, JA KELLY, JW LEIGH, DR MCRAE, AC REED, JB SMITH, RE MELCHER, GP AF WONG, MT DOLAN, MJ LATTUADA, CP REGNERY, RL GARCIA, ML MOKULIS, EC LABARRE, RC ASCHER, DP DELMAR, JA KELLY, JW LEIGH, DR MCRAE, AC REED, JB SMITH, RE MELCHER, GP TI NEURORETINITIS, ASEPTIC-MENINGITIS, AND LYMPHADENITIS ASSOCIATED WITH BARTONELLA (ROCHALIMAEA) HENSELAE INFECTION IN IMMUNOCOMPETENT PATIENTS AND PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID CAT-SCRATCH DISEASE; BACILLARY ANGIOMATOSIS; THERAPY; FEVER AB Bartonella (Rochalimaea) henselae causes a variety of diseases, including bacillary angiomatosis, peliosis hepatis, lymphadenitis, aseptic meningitis with bacteremia, and cat-scratch disease (CSD). Cases of B. henselae-related disease were collected from September 1991 through November 1993. Patients with suspected CSD, unexplained fever and lymphadenitis, or suspected B. henselae infection who were seen in the Infectious Diseases Clinic at Wilford Hall Medical Center (Lackland Air Force Base, TX) underwent physical and laboratory examinations. In addition to three previously described cases, 23 patients with R. henselae-related infection were identified. The patients included 19 immunocompetent individuals presenting with lymphadenitis (11), stellate neuroretinitis (5), Parinaud's oculoglandular syndrome with retinitis (1), chronic fatigue syndrome-like disease (1), and microbiologically proven adenitis without the presence of immunofluorescent antibodies to B, henselae (1) and four patients infected with human immunodeficiency virus type 1 presenting with isolated lymphadenitis (1), diffuse upper-extremity adenitis (1), neuroretinitis (1), and aseptic meningitis (1), A couple with neuroretinitis and their pet cat, a persistently fatigued patient, and a patient with Parinaud's oculoglandular syndrome were shown to have bacteremia, Tissue cultures were positive for B. henselae in three recent cases of adenitis, Twenty-two patients were exposed to cats, This series further demonstrates the similarities between B. henselae-related diseases and CSD and identifies several new syndromes due to B. henselae. C1 WILFORD HALL USAF MED CTR,DEPT INFECT DIS,PSMI,LACKLAND AFB,TX 78236. WILFORD HALL USAF MED CTR,DEPT OPHTHALMOL,LACKLAND AFB,TX 78236. WILFORD HALL USAF MED CTR,DEPT PEDIAT,LACKLAND AFB,TX 78236. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. FRANCIS SCOTT KEY MED CTR,INFECT DIS SECT,SCOTT AFB,MO. SAN DIEGO NAVAL AIR STN,SAN DIEGO NAVAL HOSP,SAN DIEGO,CA. KEESLER MED CTR,DEPT INTERNAL MED,KEESLER AFB,MS. CTR DIS CONTROL & PREVENT,VIRAL & RICKETTSIAL ZOONOSES BRANCH,ATLANTA,GA 30341. NR 27 TC 103 Z9 105 U1 2 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD AUG PY 1995 VL 21 IS 2 BP 352 EP 360 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RM817 UT WOS:A1995RM81700015 PM 8562744 ER PT J AU YANDEL, ML WATTERS, MR AF YANDEL, ML WATTERS, MR TI TREATMENT OF COMPLEX PARTIAL STATUS EPILEPTICUS UNMASKING ACUTE INTERMITTENT PORPHYRIA INA PATIENT WITH RESECTED ANAPLASTIC GLIOMA SO CLINICAL NEUROLOGY AND NEUROSURGERY LA English DT Note DE COMPLEX PARTIAL EPILEPSY; DELIRIUM; STATUS EPILEPTICUS; ACUTE INTERMITTENT PORPHYRIA AB We report a 42-year-old woman with an established complex partial seizure disorder, who presented in refractory complex partial status epilepticus, the treatment of which with lorazepam, phenytoin, carbamazepine, and pentobarbital precipitated an attack of acute intermittent porphyria (AIP). The subsequent clinical course and management with gabapentin is discussed. C1 TRIPLER ARMY MED CTR,DEPT MED,NEUROL SERV,HONOLULU,HI 96859. NR 17 TC 7 Z9 7 U1 0 U2 0 PU VAN GORCUM CO BV PI ASSEN PA PO BOX 43, 9400 AA ASSEN, NETHERLANDS SN 0303-8467 J9 CLIN NEUROL NEUROSUR JI Clin. Neurol. Neurosurg. PD AUG PY 1995 VL 97 IS 3 BP 261 EP 263 DI 10.1016/0303-8467(95)00051-K PG 3 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA RT465 UT WOS:A1995RT46500014 PM 7586862 ER PT J AU XENOS, JS HOPKINSON, WJ CALLAGHAN, JJ HEEKIN, RD SAVORY, CG AF XENOS, JS HOPKINSON, WJ CALLAGHAN, JJ HEEKIN, RD SAVORY, CG TI OSTEOLYSIS AROUND AN UNCEMENTED COBALT CHROME TOTAL HIP-ARTHROPLASTY SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID 3-PHASE BONE; REPLACEMENT AB One hundred consecutive uncemented Porous Coated Anatomic total hip arthroplasties performed in 91 patients who obtained prospective serial clinical and radiographic evaluation during a minimum 7-year followup period were studied for the occurrence, extent, and progression of localized periprosthetic bone loss (osteolysis). Periprosthetic bone loss occurred around the femoral component in 11 hips, the acetabular component in 2 hips, and both components in 2 hips during the followup interval. The bone loss was progressive in 6 hips (2 of 11 femoral cases, 2 of 2 acetabular cases, and 2 of 2 both component cases). It frequently occurred around components that showed no evidence of acetabular migration or femoral subsidence (11 of 15 cases). The average age at surgery of patients in the bone loss group was 10 gears younger than the nonbone loss group (in the 100 hip cohort). Clinically, most patients with bone loss were asymptomatic, with the average Harris hip rating of 92.4 points (range, 85-99 points). With this particular device at this interval of followup (7 years), the acetabular and the proximal femoral osteolytic lesions are of greatest concern. Wear of the acetabular component was greater for cases with osteolysis than for those without osteolysis, but the difference was not significant. C1 UNIV IOWA,DEPT ORTHOPAED,IOWA CITY,IA 52242. WALTER REED ARMY MED CTR,DEPT ORTHOPAED,WASHINGTON,DC. LOYOLA UNIV,DEPT ORTHOPAED,MAYWOOD,IL. HUGHSTON CLIN,COLUMBUS,GA. NR 27 TC 33 Z9 33 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD AUG PY 1995 IS 317 BP 29 EP 36 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA RP273 UT WOS:A1995RP27300006 PM 7671492 ER PT J AU CHISICK, MC AF CHISICK, MC TI COMPARING DENTAL UTILIZATION OF US ARMY SOLDIERS WITH THEIR EMPLOYED CIVILIAN COHORTS SO COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY LA English DT Article DE ACTIVE DUTY SOLDIERS; DENTAL READINESS; DENTAL UTILIZATION AB In fall 1992, a random, worldwide sample of 5474 enlisted and 4036 officer, active duty, U.S. Army personnel was surveyed on dental utilization. Overall survey response rate was 62%. After weighting the data to reflect the population, dental utilization rates of military personnel were compared with their employed civilian cohorts in the U.S. population. Results show that, regardless of race or gender, over 80% of U.S. Army personnel have seen a dentist within the past year. Controlling for age, gender, and race, active duty U.S. Army personnel have dental utilization rates that greatly exceed their employed civilian cohorts. The results suggest that access barriers to dental care present in the civilian population, especially for minorities, are greatly diminished in the U.S. Army. The results suggest that access to free care may be a potent stimulus to utilization of dental services among military or civilian personnel. Further, access to free dental care should be emphasized in recruiting and retaining U.S. military personnel. RP CHISICK, MC (reprint author), USA,INST DENT RES,KACH,ATTN SGRD UDR E LTC CHISICK EPIDEMIOL,FT GEORGE G MEADE,MD 20755, USA. NR 8 TC 5 Z9 8 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0301-5661 J9 COMMUNITY DENT ORAL JI Community Dentist. Oral Epidemiol. PD AUG PY 1995 VL 23 IS 4 BP 222 EP 225 DI 10.1111/j.1600-0528.1995.tb00235.x PG 4 WC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health SC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health GA RR277 UT WOS:A1995RR27700006 PM 7587143 ER PT J AU ROSENFIELD, RN SCHNEIDER, JW PAPP, JM SEEGAR, WS AF ROSENFIELD, RN SCHNEIDER, JW PAPP, JM SEEGAR, WS TI PREY OF PEREGRINE FALCONS BREEDING IN WEST GREENLAND SO CONDOR LA English DT Article DE FALCO PEREGRINUS; CALCARIUS LAPPONICUS; LAGOPUS MUTUS; PEREGRINE FALCON; LAPLAND LONGSPUR; ROCK PTARMIGAN; NESTLING DIET; FLEDGLINGS; SMALL PASSERINES; PREY BIOMASS; PREY SELECTION; WEST GREENLAND ID DIET AB Previous studies on the diet of Peregrine Falcons (Falco peregrinus) in Greenland were based primarily on prey remains, an indirect technique that may produce biased results. Earlier estimates of prey biomass are too general and speculative to be conclusive. No other study provided data on the age of prey species or showed that Rock Ptarmigan (Lagopus mutus) can be an important component in the diet of Greenland peregrines. We used direct observations of prey deliveries and collection of prey remains to assess prey (in terms of frequency of occurrence and biomass) of breeding Peregrine Falcons in West Greenland. We also determined prey selection in relation to local prey availability. During 492 hr of observation at two eyries we found that four small passerines-Lapland Longspur (Calcarius lapponicus), Northern Wheatear (Oenanthe oenanthe), Common Redpoll (Carduelis flammea), and Snow Bunting (Plectrophenax nivalis)-contributed over 80% of the prey items delivered, with the longspur being the principal prey species in terms of frequency of occurrence and biomass. However, ptarmigan contributed almost as much biomass as longspurs at one eyrie. Fledglings of all these bird species provided the majority of items and biomass at both eyries. Analysis of 676 prey items from prey remains at 159 eyries showed similar frequencies and rankings for the prey species comprising the majority of the diet of Peregrine Falcons as determined by prey deliveries. Lapland Longspur was taken in proportion to its availability near two eyries; ptarmigan and Snow Buntings were taken more frequently than expected. Local differences in prey use (especially ptarmigan) were found. C1 UNIV MAINE,DEPT WILDLIFE,ORONO,ME 04469. USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. RP ROSENFIELD, RN (reprint author), UNIV WISCONSIN,DEPT BIOL,STEVENS POINT,WI 54481, USA. NR 22 TC 24 Z9 25 U1 1 U2 8 PU COOPER ORNITHOLOGICAL SOC PI LAWRENCE PA ORNITHOLOGICAL SOC NORTH AMER PO BOX 1897, LAWRENCE, KS 66044-8897 SN 0010-5422 J9 CONDOR JI Condor PD AUG PY 1995 VL 97 IS 3 BP 763 EP 770 DI 10.2307/1369184 PG 8 WC Ornithology SC Zoology GA RT275 UT WOS:A1995RT27500013 ER PT J AU BHARGAVA, HK BRANLEY, WC AF BHARGAVA, HK BRANLEY, WC TI SIMULATING BELIEF SYSTEMS OF AUTONOMOUS AGENTS SO DECISION SUPPORT SYSTEMS LA English DT Article DE BELIEF SIMULATION; BELIEF GENERATION; AUTONOMOUS AGENT; DISTRIBUTED INTERACTIVE SIMULATION; BELIEF REVISION; DEFEASIBLE REASONING AB Autonomous agents in computer simulations do not have the usual mechanisms to acquire information as do their human counterparts. In many such simulations, it is not desirable that the agent have access to complete and correct information about its environment. We examine how imperfection in available information may be simulated in the case of autonomous agents. We determine probabilistically what the agent may detect, through hypothetical sensors, in a given situation. These detections are combined with the agent's knowledge base to infer observations and beliefs. Inherent: in this task is a degree of uncertainty in choosing the most appropriate observation or belief. We describe and compare two approaches -a numerical approach and one based on defeasible logic -for simulating an appropriate belief in light of conflicting detection values at a given point in time. We discuss the application of this technique to autonomous forces in combat simulation systems. C1 USA,CTR AI,WASHINGTON,DC 20310. RP BHARGAVA, HK (reprint author), USN,POSTGRAD SCH,CODE AS BH,555 DYER RD,ROOM 214,MONTEREY,CA 93943, USA. NR 17 TC 5 Z9 5 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-9236 J9 DECIS SUPPORT SYST JI Decis. Support Syst. PD AUG PY 1995 VL 14 IS 4 BP 329 EP 348 DI 10.1016/0167-9236(94)00036-R PG 20 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Operations Research & Management Science SC Computer Science; Operations Research & Management Science GA RR632 UT WOS:A1995RR63200003 ER PT J AU GIANDONI, MB VINSON, RP GRABSKI, WJ AF GIANDONI, MB VINSON, RP GRABSKI, WJ TI ISCHEMIC COMPLICATIONS OF TUBULAR GAUZE DRESSINGS SO DERMATOLOGIC SURGERY LA English DT Article AB BACKGROUND. Ischemic pressure complications associated with tubular gauze digital dressings have been occasionally reported in the medical literature. Previous authors have implicated specific mechanisms. We report a 10th case of this type of complication and hypothesize that a ''Chinese finger trap'' mechanism was responsible. OBJECTIVE. To compare pressures generated using different application techniques of tubular gauze digital dressings. METHODS. A simple device to measure dressing pressure teas constructed. Comparative pressure measurements using different application techniques were obtained. RESULTS. Too many layers, excess longitudinal traction during application, using move than a 90 degrees twist during application, and rolled proximal dressing edges all increased measured pressures significantly. CONCLUSIONS. Physicians and other health care providers involved in the application of these dressings should be aware of their correct application and the mechanisms that may produce complications. C1 BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234. NR 7 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD AUG PY 1995 VL 21 IS 8 BP 716 EP 718 PG 3 WC Dermatology; Surgery SC Dermatology; Surgery GA RN704 UT WOS:A1995RN70400009 PM 7633818 ER PT J AU CLEMENT, S AF CLEMENT, S TI DIABETES SELF-MANAGEMENT EDUCATION SO DIABETES CARE LA English DT Review ID PATIENT-EDUCATION; METABOLIC CONTROL; CONTROLLED TRIAL; BLOOD-GLUCOSE; TEACHING PROGRAM; GLYCEMIC CONTROL; INSULIN THERAPY; STRUCTURED TREATMENT; GROUP INTERVENTION; TREATED PATIENTS RP CLEMENT, S (reprint author), WALTER REED ARMY MED CTR,DIABET CLIN & ENDOCRINE METAB SERV,WASHINGTON,DC 20307, USA. NR 113 TC 221 Z9 229 U1 4 U2 8 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1660 DUKE ST, ALEXANDRIA, VA 22314 SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD AUG PY 1995 VL 18 IS 8 BP 1204 EP 1214 PG 11 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA RM113 UT WOS:A1995RM11300026 PM 7587866 ER PT J AU HENSELMAN, LW HENDERSON, D SHADOAN, J SUBRAMANIAM, M SAUNDERS, S OHLIN, D AF HENSELMAN, LW HENDERSON, D SHADOAN, J SUBRAMANIAM, M SAUNDERS, S OHLIN, D TI EFFECTS OF NOISE EXPOSURE, RACE, AND YEARS OF SERVICE ON HEARING IN US ARMY SOLDIERS SO EAR AND HEARING LA English DT Article ID AGE AB Over the last two decades the U.S. Army has instituted a comprehensive hearing conservation program (HCP) to reduce the prevalence of hearing loss in soldiers and civilian employees. As a component of this program, hearing threshold levels (HTLs) are stored in a central computerized Army-wide hearing conservation data registry. The aim of this study was to analyze the hearing threshold data to compare the hearing loss among soldiers representing different (1) race groups, (2) noise exposure groups, and (3) durations of military service. HTLs were age-corrected using data base B values from ISO 1999 (1990). As may be expected, soldiers exposed to high noise levels had significantly poorer hearing than the group of soldiers with limited noise exposure. On the average, results indicated a significant difference in HTLs among the race groups with black soldiers having the most sensitive hearing and white soldiers having the poorest. Also, subjects with greater durations of military service had the least sensitive hearing. Finally, race and years of service factors were found to interact in their effect on HTL. The findings are discussed in terms of implications of race differences, normative data, and effectiveness of the U.S. Army HCP. C1 SUNY BUFFALO,DEPT COMMUN SCI & DISORDERS,HEARING RES LAB,BUFFALO,NY. FT DETRICK DATA PROC CTR,OCCUPAT HLTH MANAGEMENT INFORMAT SYST,FREDERICK,MD. USA,ENVIRONM HYG AGCY,DIV BIOACOUST,ABERDEEN PROVING GROUND,MD. NR 26 TC 29 Z9 30 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0196-0202 J9 EAR HEARING JI Ear Hear. PD AUG PY 1995 VL 16 IS 4 BP 382 EP 391 DI 10.1097/00003446-199508000-00005 PG 10 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA RN825 UT WOS:A1995RN82500005 PM 8549894 ER PT J AU DAVIS, TA WIESMANN, W KIDWELL, WR CANNON, T KERNS, L SERKE, C DELAPLAINE, T PRANGER, A LEE, KP AF DAVIS, TA WIESMANN, W KIDWELL, WR CANNON, T KERNS, L SERKE, C DELAPLAINE, T PRANGER, A LEE, KP TI EFFECT OF SPACE-FLIGHT ON CD34(+) CELL HEMATOPOIESIS - SUPPRESSION OF ERYTHROPOIESIS AND MYELOPOIESIS SO EXPERIMENTAL HEMATOLOGY LA English DT Meeting Abstract C1 USN,MED RES INST,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. CELLCO INC,GERMANTOWN,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CARDEN JENNINGS PUBL COLTD PI CHARLOTTESVILLE PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903 SN 0301-472X J9 EXP HEMATOL JI Exp. Hematol. PD AUG PY 1995 VL 23 IS 8 BP 769 EP 769 PG 1 WC Hematology; Medicine, Research & Experimental SC Hematology; Research & Experimental Medicine GA RP116 UT WOS:A1995RP11600099 ER PT J AU STOJADINOVIC, A KIANG, J SMALLRIDGE, R GALLOWAY, R SHEADONOHUE, T AF STOJADINOVIC, A KIANG, J SMALLRIDGE, R GALLOWAY, R SHEADONOHUE, T TI INDUCTION OF HEAT-SHOCK PROTEIN-72 PROTECTS AGAINST ISCHEMIA-REPERFUSION IN RAT SMALL-INTESTINE SO GASTROENTEROLOGY LA English DT Article ID XANTHINE-OXIDASE; MUCOSAL DAMAGE; STRESS; LEUKOTRIENE-B4; INJURY; CELLS; INFILTRATION; LEUKOCYTES; FLOW AB Background & Aims: Induction of heat-shock protein 72 is associated with enhanced tolerance to subsequent nonthermal stresses. This study evaluated whether induction of heat-shock protein 72 protects against intestinal ischemia/reperfusion injury. Methods: Groups of nonheated and heated vats underwent sham operation, 30 minutes of ischemia by occlusion of the superior mesenteric artery, or ischemia followed by 60 minutes of reperfusion. Whole-body hyperthermia to a core temperature of 41.5-42 degrees C for 15-20 minutes was followed by passive cooling 2-3 hours before the experiment. Samples of small intestine were obtained for determination of heat-shock protein 72 production and ex vivo generation of prostaglandin E(2) and leukotriene B-4 and for histological assessment of mucosal injury and number of neutrophils. Results: Hyperthermia significantly increased heat-shock protein 72 production and significantly reduced ischemia/reperfusion-induced mucosal injury, neutrophilic infiltration, and leukotriene B-4 production. Levels of leukotriene B-4 and numbers of neutrophils were well correlated in nonheated (r = 0.72) but not in heated groups (r = -0.16). The elevation of prostaglandin E(2) levels in response to ischemia and reperfusion was unaltered by hyperthermia. Conclusions: The mechanism of heat stress-induced protection against intestinal ischemia/reperfusion injury involves inhibition of leukotriene B-4 production and subsequent prevention of neutrophil activation and chemotaxis. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC. NR 26 TC 107 Z9 109 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD AUG PY 1995 VL 109 IS 2 BP 505 EP 515 DI 10.1016/0016-5085(95)90339-9 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA RM508 UT WOS:A1995RM50800021 PM 7615200 ER PT J AU TAYAG, TJ MACKIE, DM BRYANT, GW AF TAYAG, TJ MACKIE, DM BRYANT, GW TI A MANUFACTURABLE TECHNIQUE FOR IMPLEMENTING LOW-LOSS SELF-IMAGING WAVE-GUIDE BEAMSPLITTERS SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article ID WAVE-GUIDES; INP; ULTRACOMPACT; SPLITTER AB A manufacturable technique to implement self-imaging waveguide beamsplitters is proposed and demonstrated. This technique offers low insertion loss and polarization crosstalk, uniform splitting ratios, ease in manufacture, and most importantly application to diverse waveguide material systems, Beamsplitters with splitting ratios that range from 1 x 2 through 1 x 17 were fabricated in GaAs-AlGaAs waveguides, For 1 x 16 splitters integrated with an output ridge waveguide array, the insertion losses in many devices were less than the insertion losses in adjacent straight-through ridge waveguides, The best uniformity spread among the 16 channels was +/-7.8% and the TE-to-TM and TM-to-TE polarization crosstalks were lower than -25 dB. C1 NIST,GAITHERSBURG,MD 20899. RP TAYAG, TJ (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 11 TC 10 Z9 10 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD AUG PY 1995 VL 7 IS 8 BP 896 EP 898 DI 10.1109/68.404007 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA RP038 UT WOS:A1995RP03800025 ER PT J AU LEE, CS NALBANDIAN, V SCHWERING, F AF LEE, CS NALBANDIAN, V SCHWERING, F TI PLANAR DUAL-BAND MICROSTRIP ANTENNA SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Note AB A novel dual-band microstrip antenna is introduced. The entire structure is planar and can be easily mass-produced by using printed-circuit technology. The antenna consists of multiple layers with metallic strips placed at one of the dielectric interfaces under the radiating patch. The resonant frequencies can be selected over a wide frequency range and the impedance matching at those two frequencies is relatively simple. The physically intuitive cavity model is used for the analysis. A relatively simple design scheme is included. C1 USA,CECOM,FT MONMOUTH,NJ 07703. RP LEE, CS (reprint author), SO METHODIST UNIV,DEPT ELECT ENGN,DALLAS,TX 75275, USA. NR 8 TC 11 Z9 12 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD AUG PY 1995 VL 43 IS 8 BP 892 EP 894 PG 3 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA RP260 UT WOS:A1995RP26000020 ER PT J AU JONES, JR TAIT, GB JONES, SH KATZER, DS AF JONES, JR TAIT, GB JONES, SH KATZER, DS TI DC AND LARGE-SIGNAL TIME-DEPENDENT ELECTRON-TRANSPORT IN HETEROSTRUCTURE DEVICES - AN INVESTIGATION OF THE HETEROSTRUCTURE BARRIER VARACTOR SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article ID RAY PHOTOEMISSION SPECTROSCOPY; HETEROJUNCTION BAND OFFSETS; SUBMILLIMETER-WAVE POWER; MILLIMETER-WAVE; CYCLOTRON-RESONANCE; MATERIAL PARAMETERS; NUMERICAL-ANALYSIS; BOUNDARY-CONDITION; INP; DIODES AB The dc and large-signal time-dependent electron transport properties of Heterostructure Barrier Varactors (HBVs) are investigated using a physical model which combines drift-diffusion current transport through the heterostructure bulk with thermionic and thermionic-field emission currents imposed at the abrupt heterointerfaces in a fully self-consistent manner. A fast and accurate hydrodynamic device simulator for generic unipolar InGaAs/InAlAs on InP, InGaAs/InP on InP, and GaAs/InGaAs/AlGaAs on GaAs HBVs has been developed based on this model. The experimentally observed current-voltage and capacitance-voltage characteristics of GaAs/AlGaAs and GaAs/InGaAs/AlGaAs HBVs are compared with the simulated results over a wide range of de bias. Large-signal time dependent simulations at a pump frequency of 100 GHz confirm the odd-harmonic operation of these devices and indicate that multiple barrier HBVs should provide efficient frequency multiplication, especially in high order frequency multipliers, broadband frequency triplers, and quasi-optical tripler arrays. C1 US MIL ACAD,DEPT ELECT ENGN & COMP SCI,W POINT,NY 10996. USN,RES LAB,DIV ELECTR SCI & TECHNOL,WASHINGTON,DC 20375. RP JONES, JR (reprint author), UNIV VIRGINIA,DEPT ELECT ENGN,CHARLOTTESVILLE,VA 22903, USA. RI Katzer, D. Scott/N-7841-2013 NR 48 TC 18 Z9 18 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD AUG PY 1995 VL 42 IS 8 BP 1393 EP 1403 DI 10.1109/16.398654 PG 11 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA RJ150 UT WOS:A1995RJ15000001 ER PT J AU ZARI, MC ANDERSON, CS CARAWAY, WD AF ZARI, MC ANDERSON, CS CARAWAY, WD TI AN X-BAND ACOUSTOOPTIC VARIABLE DELAY-LINE FOR RADAR TARGET SIMULATION SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article AB The design and characterization of a 54-mu s, continuously-variable, acousto-optic (AO) delay line developed for radar testing applications is presented, Design goals for the delay line include over 10 MHz of instantaneous bandwidth, 1.2 GHz of tunable bandwidth operating at X-band, 45 dB of dynamic range, and electronically-controllable delay selection to simulate dynamic radar targets with radial range rates up to 500 m/s, In addition, the device was designed to have phase noise and spurious signal levels compatible with high performance radars, To achieve these goals, a 33-MHz center frequency variable delay line was constructed and coherent frequency translation was used to provide operation at S-band, Operating principles for this new intermediate frequency (LF) delay line are presented, and key component issues are discussed, A computer design and analysis tool is described that predicts delay line performance. Experimental results are presented at both the IF and at X-band. C1 UNIV FLORIDA,CTR GRAD RES ENGN,EGLIN AFB,FL. USA,MICOM,HUNTSVILLE,AL. RP ZARI, MC (reprint author), DYNET INC,HUNTSVILLE,AL, USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD AUG PY 1995 VL 43 IS 8 BP 1889 EP 1894 DI 10.1109/22.402272 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA RN565 UT WOS:A1995RN56500019 ER PT J AU TSENG, JN KOMISAR, JL TROUT, RN HUNT, RE CHEN, JYJ JOHNSON, AJ PITT, L RUBLE, DL AF TSENG, JN KOMISAR, JL TROUT, RN HUNT, RE CHEN, JYJ JOHNSON, AJ PITT, L RUBLE, DL TI HUMORAL IMMUNITY TO AEROSOLIZED STAPHYLOCOCCAL-ENTEROTOXIN-B (SEB), A SUPERANTIGEN, IN MONKEYS VACCINATED WITH SEB TOXOID-CONTAINING MICROSPHERES SO INFECTION AND IMMUNITY LA English DT Article ID STIMULATORY FACTOR-I; TOXIC-SHOCK SYNDROME; HUMAN T-CELLS; UNSENSITIZED MONKEYS; CHALLENGE; INDUCTION; ANERGY; MICE; IGG1 AB Staphylococcal enterotoxin B (SEB) toxoid containing microspheres were tested for efficacy;cy in rhesus monkeys as a vaccine candidate for respiratory SEB toxicosis and toxic shock. Forty monkeys were randomly separated into 10 groups of four monkeys each: 9 groups were vaccinated with the microspheres via combinations of mucosal and nonmucosal routes, and 1 group Served as nonvaccinated controls. Both vaccinated and nonvaccinated monkeys were then challenged with a high lethal dose of SEB aerosol. Monkeys primed with an intramuscular dose of the microspheres followed by an intratracheal booster all survived the SEB challenge. Overall, monkeys with an intratracheal booster generally had the highest antibody levels, which is consistent with their high survival rate and lower rate of illness. Protective immunity was correlated with antibody levels in both the circulation and the respiratory tract, The protection was not due to the depletion or anergy of SEB-reactive T cells, since SEB-induced proliferation in cultures of circulating lymphocytes was not significantly reduced after the microsphere vaccination. It is evident that the nonsurvivors did not die of systemic anaphylaxis or hypersensitivity because the monkeys did not die immediately after SEB challenge and there were no significant differences in histamine levels between the vaccinated and control monkeys before and after SEB challenge. The antibodies seemed to neutralize the SEB that got into the airway and the circulation. C1 USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV VET MED,FREDERICK,MD 21702. RP TSENG, JN (reprint author), WALTER REED ARMY INST RES,DEPT EXPTL PATHOL,DIV PATHOL,WASHINGTON,DC 20307, USA. NR 37 TC 48 Z9 53 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD AUG PY 1995 VL 63 IS 8 BP 2880 EP 2885 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA RK640 UT WOS:A1995RK64000012 PM 7542634 ER PT J AU JOHNSON, E JAAX, N WHITE, J JAHRLING, P AF JOHNSON, E JAAX, N WHITE, J JAHRLING, P TI LETHAL EXPERIMENTAL INFECTIONS OF RHESUS-MONKEYS BY AEROSOLIZED EBOLA-VIRUS SO INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY LA English DT Article DE EBOLA VIRUS; AEROGENIC INFECTION; RHESUS MONKEY ID DISEASE; FEVER AB The potential of aerogenic infection by Ebola virus was established by using a head-only exposure aerosol system. Virus-containing droplets of 0.8-1.2 mu m were generated and administered into the respiratory tract of rhesus monkeys via inhalation. Inhalation of viral doses as low as 400 plaque-forming units of virus caused a rapidly fatal disease in 4-5 days. The illness was clinically identical to that reported for parenteral virus inoculation, except for the occurrence of subcutaneous and venipuncture site bleeding and serosanguineous nasal discharge. Immunocytochemistry revealed cell-associated Ebola virus antigens present in airway epithelium, alveolar pneumocytes, and macrophages in the lung and pulmonary lymph nodes; extracellular antigen was present on mucosal surfaces of the nose, oropharynx and airways. Aggregates of characteristic filamentous virus were present within type I pneumocytes, macrophages, and air spaces of the lung by electron microscopy. Demonstration of fatal aerosol transmission of this virus in monkeys reinforces the importance of taking appropriate precautions to prevent its potential aerosol transmission to humans. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 30 TC 178 Z9 186 U1 1 U2 26 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0959-9673 J9 INT J EXP PATHOL JI Int. J. Exp. Pathol. PD AUG PY 1995 VL 76 IS 4 BP 227 EP 236 PG 10 WC Pathology SC Pathology GA RR154 UT WOS:A1995RR15400002 PM 7547435 ER PT J AU FREY, R LAWRENCE, W CHICK, M AF FREY, R LAWRENCE, W CHICK, M TI SHOCK EVOLUTION AFTER SHAPED CHARGE JET IMPACT AND ITS RELEVANCE TO EXPLOSIVE INITIATION SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article AB When a shaped charge jet impacts a target containing explosive, the explosive may be initiated by one of three shocks: the impact shock, a bow shock that forms in the inert plate covering the exlosive, or a bow shock that forms in the explosive. In this paper, numerical calculations are used to determine how thick the cover plate must be to prevent initiation by the impact shock and how much time (or distance) is required to form a bow shock in the explosive. The results show that the cover plate must be from 4 to 12 jet diameters (depending on jet velocity) thick to sufficiently attenuate the impact shock so that it will not cause initiation in a common secondary explosive. For a 7-km/s copper jet, a distance of about 8 jet diameters was required to form a bow shock in the explosive. This corresponds well to experimental data reported elsewhere. C1 AERONAUT & MARITIME RES LAB,ASCOT,VIC 3032,AUSTRALIA. RP FREY, R (reprint author), USA,RES LAB,WEAPONS TECHNOL DIRECTORATE,EXPLOS TECHNOL BRANCH,ABERDEEN PROVING GROUND,MD 21005, USA. NR 7 TC 5 Z9 5 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD AUG PY 1995 VL 16 IS 4 BP 563 EP 570 DI 10.1016/0734-743X(94)00064-4 PG 8 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA RR335 UT WOS:A1995RR33500002 ER PT J AU MAEL, FA AF MAEL, FA TI STAYING AFLOAT - WITHIN-GROUP SWIMMING PROFICIENCY FOR WHITES AND BLACKS SO JOURNAL OF APPLIED PSYCHOLOGY LA English DT Article ID EPIDEMIOLOGY; BIODATA; DENSITY AB Generally, Blacks are less likely than Whites to be proficient at swimming. Blacks also have higher rates of drowning and are underrepresented in competitive swimming and in occupations requiring swimming or water safety skill. In this study, physiological, demographic, and biodata measures were used with military academy cadets to determine the individual factors contributing to within-group swimming proficiency among Blacks as well as Whites. The best predictor of swimming skill was the age at which the cadets had learned to swim. Other items pointed to fitness, sociocultural, and learned or dispositional differences between better and poorer swimmers. Implications for increasing swimming proficiency among Blacks and for future research are discussed. RP MAEL, FA (reprint author), USA,RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 49 TC 7 Z9 7 U1 0 U2 1 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0021-9010 J9 J APPL PSYCHOL JI J. Appl. Psychol. PD AUG PY 1995 VL 80 IS 4 BP 479 EP 490 DI 10.1037//0021-9010.80.4.479 PG 12 WC Psychology, Applied; Management SC Psychology; Business & Economics GA RN700 UT WOS:A1995RN70000004 ER PT J AU ZUBER, M HOOVER, TA COURT, DL AF ZUBER, M HOOVER, TA COURT, DL TI ANALYSIS OF A COXIELLA-BURNETII GENE-PRODUCT THAT ACTIVATES CAPSULE SYNTHESIS IN ESCHERICHIA-COLI - REQUIREMENT FOR THE HEAT-SHOCK CHAPERONE DNAK AND THE 2-COMPONENT REGULATOR RCSC SO JOURNAL OF BACTERIOLOGY LA English DT Article ID PSEUDOMONAS-AERUGINOSA; POLYSACCHARIDE SYNTHESIS; PLASMID VECTOR; RNC OPERON; K-12; IDENTIFICATION; EXPRESSION; CLONING; PROTEINS; MUTATION AB A 1.2-kb EcoRI genomic DNA fragment of Coxiella burnetii, when cloned onto a multicopy plasmid, was found to induce capsule synthesis (mucoidy) in Escherichia coli. Nucleotide sequence analysis revealed the presence of an open reading frame that could encode a protein of 270 amino acids. Insertion of a tet cassette into a unique NruI restriction site resulted in the loss of induction of mucoidy. Because of its ability to induce mucoidy, we designated this gene mucZ. Computer search for homologies to mucZ revealed 42% identity to an open reading frame located at 1 min of the E. coli chromosome. Interestingly, the C-terminal amino acid residues of MucZ share significant homology with the J domain of the DnaJ protein and its homologs, suggesting potential interactions between MucZ and components of the DnaK-chaperone machinery. Results presented in this paper suggest that E. coli requires DnaK-chaperone machinery for Lon-RcsA-mediated induction of capsule synthesis, as noticed first by S. Gottesman (personal communication). The induction caused by MucZ is independent of Lon-RcsA and is mediated through the two-component regulators RcsC and RcsB. DnaK and GrpE but not DnaJ are also required for the RcsB-mediated MucZ induction, and we propose that MucZ is a DnaJ-like chaperone protein that might be required for the formation of an active RcsA-RcsB complex and for the RcsC dependent phosphorylation of RcsB. Discussions are presented that suggest three different roles for alternative forms of the DnaK-chaperone machinery in capsule production. C1 USA,MED RES INST INFECT DIS,DIV BACTERIOL,FREDERICK,MD 21702. NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,CHROMOSOME BIOL LAB,FREDERICK,MD 21702. RP ZUBER, M (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702, USA. FU PHS HHS [N01-C0-46000] NR 41 TC 36 Z9 38 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD AUG PY 1995 VL 177 IS 15 BP 4238 EP 4244 PG 7 WC Microbiology SC Microbiology GA RL828 UT WOS:A1995RL82800006 PM 7635811 ER PT J AU CROSS, A ASHER, L SEGUIN, M YUAN, L KELLY, N HAMMACK, C SADOFF, J GERNSKI, P AF CROSS, A ASHER, L SEGUIN, M YUAN, L KELLY, N HAMMACK, C SADOFF, J GERNSKI, P TI THE IMPORTANCE OF A LIPOPOLYSACCHARIDE-INITIATED, CYTOKINE-MEDIATED HOST-DEFENSE MECHANISM IN MICE AGAINST EXTRAINTESTINALLY INVASIVE ESCHERICHIA-COLI SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article DE SEPSIS; BACTEREMIA; ENDOTOXIN; C3H MICE; MACROPHAGE ID TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; MONOCLONAL-ANTIBODIES; NEWBORN RATS; K-ANTIGENS; MACROPHAGES; BACTEREMIA; STRAINS; PHAGOCYTOSIS; RESISTANCE AB Extraintestinally invasive Escherichia coli (EC) that possess both a complete LPS and K1 capsule evade both complement-mediated bacteriolysis and neutrophil-mediated killing. Since C3H/HeJ mice that are hyporesponsive to LPS were uniquely susceptible to lethal infection with EC of this phenotype, we speculated there was an LPS-initiated host defense mechanism against this pathogenic phenotype, The LPS-normoresponsive C3H/HeN as well, as the C3H/HeJ mice cleared these EC from the circulation within 4 h of intravenous administration, Whereas electron micrographs of the liver demonstrated these EC undergoing degeneration within the phagolysosomes of of both macrophages and Kupffer cells of C3H/HeN mice, these EC replicated within these cells of the C3H/HeJ mice, Restoration of anti-EC activity of C3H/HeJ mice occurred with activation of Kupffer cells and peritoneal macrophages in vivo with BCG and in vitro with IFN-gamma, but not with LPS, Pretreatment of C3H/HeJ mice with a combination of recombinant murine IL-1 and TNF-alpha also restored the killing of K1(+)-EC but did not enhance the killing of a K1(-)-EC mutant. These data are consistent with the hypothesis that (a) there is no intrinsic inability of C3H/HeJ phagocytes to kill EC, but (b) an LPS-initiated, cytokine-mediated host defense mechanism is required for such killing. These studies emphasize the importance of bacterial surface characteristics in the interaction with specific host defenses. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. NR 43 TC 102 Z9 103 U1 0 U2 1 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD AUG PY 1995 VL 96 IS 2 BP 676 EP 686 DI 10.1172/JCI118110 PG 11 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA RM466 UT WOS:A1995RM46600004 PM 7635960 ER PT J AU GOUVEA, V AF GOUVEA, V TI SURVEY OF ROTAVIRUS G-TYPE AND P-TYPE ASSOCIATED WITH HUMAN GASTROENTERITIS IN SAO-PAULO, BRAZIL, FROM 1986 TO 1992 - REPLY SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Letter RP GOUVEA, V (reprint author), WALTER REED ARMY MED CTR,DEPT VIRAL DIS,WASHINGTON,DC 20307, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD AUG PY 1995 VL 33 IS 8 BP 2231 EP 2231 PG 1 WC Microbiology SC Microbiology GA RJ052 UT WOS:A1995RJ05200064 ER PT J AU HUTCHISON, RE BERARD, CW SHUSTER, JJ LINK, MP PICK, TE MURPHY, SB AF HUTCHISON, RE BERARD, CW SHUSTER, JJ LINK, MP PICK, TE MURPHY, SB TI B-CELL LINEAGE CONFERS A FAVORABLE OUTCOME AMONG CHILDREN AND ADOLESCENTS WITH LARGE-CELL LYMPHOMA - A PEDIATRIC-ONCOLOGY-GROUP STUDY SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID NON-HODGKINS-LYMPHOMAS; T-CELL; MONOCLONAL-ANTIBODY; CLINICAL-FEATURES; KI-1 LYMPHOMA; IMMUNOLOGICAL CHARACTERIZATION; MALIGNANT HISTIOCYTOSIS; PROGNOSTIC-SIGNIFICANCE; GENOTYPIC ANALYSIS; TISSUE-SECTIONS AB Purpose: The goal of this study was to assess the immunophenotype of uniformly treated cases of pediatric large-cell non-Hodgkin's lymphoma (NHL) to determine the prognostic importance of B-cell and T-cell lineages and of CD30 positivity. Patients and Methods: Sixty-nine patients were analyzed by immunochemistry. All patients were classified histologically, staged in a uniform manner, and treated according to one of two protocols for localized (stage I and II) NHL or advanced (stage III and IV) large-cell NHL. Antibodies included anti-CD45, CD20, CD45Ra, MB-2 (not clustered), CD3, CD45Ro, CD43, CD15, CD30, and CD68. Statistical analysis used the exact conditional chi(2) and Kruskall-Wallace tests for clinical features and the log-rank test to evaluate event-free survival (EFS). Results: Immunophenotypic results demonstrated 25 B-cell, 23 T-cell, and 21 indeterminate lineage. Twenty-seven patients expressed CD30 (17 T-cell and 10 indeterminate lineage), and of these, 22 showed histology of anaplastic large-cell lymphoma (ALCL). B-cell patients were older (P = .018) and showed more favorable survival than patients with T-cell or indeterminate lineage (96% EFS at 3 years, 96% v 67% and 74%, B v T and indeterminate lineage [P = .027]). B-cell lineage was seen more frequently in limited-stage patients, but was also associated with favorable survival when stratified for stage (P = .036). CD30 expression (P = .96) and ALCL histology (P = .90) did not show significant associations with survival. Conclusion: We conclude that among pediatric large-cell lymphomas, B-cell lineage is proportionately less frequent than in adults and CD30 antigen-expressing lymphomas are frequent among patients with T-cell and indeterminate lineage. B-cell phenotype tends to occur in older children and is associated with superior survival. (C) 1995 by American Society of Clinical Oncology. C1 SUNY HLTH SCI CTR, SYRACUSE, NY 13210 USA. ST JUDE CHILDRENS RES HOSP, MEMPHIS, TN 38105 USA. PEDIAT ONCOL GRP, STAT OFF, GAINESVILLE, FL USA. UNIV FLORIDA, GAINESVILLE, FL USA. STANFORD UNIV, SCH MED, PALO ALTO, CA 94304 USA. BROOKE ARMY MED CTR, FT SAM HOUSTON, TX 78234 USA. NORTHWESTERN UNIV, CHILDRENS MEM HOSP, EVANSTON, IL 60208 USA. PEDIAT ONCOL GRP, CHICAGO, IL USA. FU NCI NIH HHS [CA-28383, CA-31566, CA-30969] NR 51 TC 31 Z9 31 U1 0 U2 2 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD AUG PY 1995 VL 13 IS 8 BP 2023 EP 2032 PG 10 WC Oncology SC Oncology GA RM473 UT WOS:A1995RM47300024 PM 7636544 ER PT J AU WIK, SJ AF WIK, SJ TI RESERVOIR DRAWDOWN - CASE-STUDY IN FLOW CHANGES TO POTENTIALLY IMPROVE FISHERIES SO JOURNAL OF ENERGY ENGINEERING-ASCE LA English DT Article AB Salmon populations in the Columbia River Basin have declined, and several species are now protected under the Endangered Species Act. Many factors have contributed to the decline, including overharvest, loss of habitat, degradation of water quality, and construction of dams. Many measures have been implemented to reduce the impact of the darns, but additional measures are being considered. Lowering water-surface elevations behind four lower Snake River dams has been proposed as a measure to improve juvenile salmonid survival. The Corps of Engineers has determined preliminary costs, schedules, and required modifications for several drawdown alternatives. Initial estimates of the ability of this type of operation to improve salmonid survival are controversial. RP WIK, SJ (reprint author), USA,CORPS ENGINEERS,WALLA WALLA,WA 99347, USA. NR 4 TC 5 Z9 5 U1 1 U2 6 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9402 J9 J ENERG ENG-ASCE JI J. Energy Eng.-ASCE PD AUG PY 1995 VL 121 IS 2 BP 89 EP 96 DI 10.1061/(ASCE)0733-9402(1995)121:2(89) PG 8 WC Energy & Fuels; Engineering, Civil SC Energy & Fuels; Engineering GA RL245 UT WOS:A1995RL24500005 ER PT J AU CERCO, CF AF CERCO, CF TI RESPONSE OF CHESAPEAKE BAY TO NUTRIENT LOAD REDUCTIONS SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article ID PHYTOPLANKTON; SEDIMENTS; RIVER AB A eutrophication model package was employed to examine the response of mainstem Chesapeake Bay to nitrogen and phosphorus load reductions. In addition to sensitivity analyses, the bay was examined under limit-of-technology nutrient controls and all-forest conditions. Scenarios were run in a time-variable mode for a minimum of 10 years. Decade-long simulations were required to achieve a near-complete response to load reductions. Analyses indicated that the primary effect of phosphorus controls was the limitation of algal biomass during the spring bloom and in the upper bay during summer. Nitrogen controls limited algal biomass primarily in the lower bay. Nitrogen controls were more effective than phosphorus controls in limiting algal production and in reducing anoxic volume. Limit-of-technology load reductions, under average hydrologic conditions, improved minimum summer-dissolved oxygen by approximate to 0.5 gm m(-3) and reduced anoxic volume by 40%. Anoxia was largely absent under all-forest, average hydrologic conditions but persisted during wet, highly stratified years. RP CERCO, CF (reprint author), USA,ENGINEER WATERWAYS EXPT STN,MAIL STOP ES-Q,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 19 TC 43 Z9 43 U1 0 U2 6 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD AUG PY 1995 VL 121 IS 8 BP 549 EP 557 DI 10.1061/(ASCE)0733-9372(1995)121:8(549) PG 9 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA RK485 UT WOS:A1995RK48500002 ER PT J AU HUNG, PH CALDWELL, JB JAMES, WD AF HUNG, PH CALDWELL, JB JAMES, WD TI MINOCYCLINE-INDUCED HYPERPIGMENTATION SO JOURNAL OF FAMILY PRACTICE LA English DT Note DE MINOCYCLINE; HYPERPIGMENTATION; PIGMENTATION; ADVERSE EFFECTS; SIDE EFFECTS ID INDUCED PIGMENTATION; THERAPY; SKIN; DISCOLORATION; SECONDARY; TOOTH; TEETH; NAIL AB A 70-year-old man developed hyperpigmentation of his forearms, hands, fingernails, sclerae, ears, and teeth after 9 years of therapy with minocycline for acne rosacea. Minocycline is widely used in the treatment of acne vulgaris and uncommonly produces the side effect of hyperpigmentation. This effect does not appear to be dose-dependent and usually resolves within months to years after discontinuation of therapy. Discoloration of adult teeth, however, is generally permanent. C1 PENTAGON ARMY HLTH CLIN,WASHINGTON,DC. WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. MARTIN ARMY COMMUNITY HOSP,DEPT DERMATOL,FT BENNING,GA. NR 26 TC 14 Z9 14 U1 1 U2 1 PU APPLETON & LANGE PI E NORWALK PA 25 VAN ZANT ST, E NORWALK, CT 06855 SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD AUG PY 1995 VL 41 IS 2 BP 183 EP 185 PG 3 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA RN979 UT WOS:A1995RN97900011 PM 7636458 ER PT J AU ANDERSEN, GR TORREY, VH AF ANDERSEN, GR TORREY, VH TI FUNCTION-BASED CONDITION INDEXING FOR EMBANKMENT DAMS SO JOURNAL OF GEOTECHNICAL ENGINEERING-ASCE LA English DT Article AB A total-systems approach is presented for the development of condition-indexing systems for aging civil engineering facilities that formalizes the necessary decision-making process. An application is given for embankment darns. A condition-indexing system is a tool that defines the physical state of a given facility or a portion thereof in terms of a numerical condition index. The index can be used as the criterion or as one among several criteria for prioritization of repair, evaluation, maintenance, and rehabilitation (REMR) expenditures among many similar systems. The proposed methodology will generate the essential elements of a condition-indexing system and includes the identification of specific objectives for REMR activities, the consideration of complex interactions between subunits of the facility, and the identification of critical system components. A condition-index vector is developed by considering the subunits of the facility repeatedly for the multiple REMR objectives. This vector can be converted into a scalar by applying weighting functions that describe the relative importance of each REMR objective. C1 USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP ANDERSEN, GR (reprint author), TULANE UNIV,DEPT CIVIL & ENVIRONM ENGN,6823 ST CHARLES AVE,NEW ORLEANS,LA 70118, USA. NR 12 TC 5 Z9 5 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9410 J9 J GEOTECH ENG-ASCE JI J. Geotech. Eng.-ASCE PD AUG PY 1995 VL 121 IS 8 BP 579 EP 588 DI 10.1061/(ASCE)0733-9410(1995)121:8(579) PG 10 WC Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA RL106 UT WOS:A1995RL10600001 ER PT J AU HITE, JE MIH, WC AF HITE, JE MIH, WC TI VELOCITY OF AIR-CORE VORTICES AT HYDRAULIC INTAKES (VOL 120, PG 284, 1994) SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Correction, Addition C1 WASHINGTON STATE UNIV,DEPT CIVIL & ENVIRONM ENGN,PULLMAN,WA 99164. RP HITE, JE (reprint author), USA,CORPS ENGINEERS,HYDROL LAB,WTRWY EXPTL STN,VICKSBURG,MS 39180, USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD AUG PY 1995 VL 121 IS 8 BP 631 EP 631 DI 10.1061/(ASCE)0733-9429(1995)121:8(631) PG 1 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA RK707 UT WOS:A1995RK70700009 ER PT J AU HITE, JE MIH, WC AF HITE, JE MIH, WC TI VELOCITY OF AIR-CORE VORTICES AT HYDRAULIC INTAKES SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Discussion C1 WASHINGTON STATE UNIV,DEPT CIVIL & ENVIRONM ENGN,ALBROOK HYDR LAB,PULLMAN,WA 99164. RP HITE, JE (reprint author), USA,CORPS ENGINEERS,HYDROL LAB,WTRWY EXPTL STN,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD AUG PY 1995 VL 121 IS 8 BP 631 EP 631 DI 10.1061/(ASCE)0733-9429(1995)121:8(631) PG 1 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA RK707 UT WOS:A1995RK70700008 ER PT J AU TRACY, FT AF TRACY, FT TI 1-D, 2-D, AND 3-D ANALYTICAL SOLUTIONS OF UNSATURATED FLOW IN GROUNDWATER SO JOURNAL OF HYDROLOGY LA English DT Article ID NONLINEAR DIFFUSION AB An excellent tool for checking numerical models of unsaturated flow in groundwater is analytical solutions. However, because of the highly nonlinear nature of the governing partial differential equation, only a limited number of analytical solutions are available. This paper first gives some simple 1-D solutions. Next, by use of a transformation, the nonlinear partial differential equation is converted to a linear one for a specific form of the moisture content vs. pressure head and relative hydraulic conductivity vs. pressure head curves. This allows both 2-D and 3-D solutions to be derived, which is done in this paper. Finally, computations from a finite element computer program are compared with results from one of the analytical solutions to illustrate the use of the derived equations. RP TRACY, FT (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 7 TC 18 Z9 19 U1 2 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 J9 J HYDROL JI J. Hydrol. PD AUG PY 1995 VL 170 IS 1-4 BP 199 EP 214 DI 10.1016/0022-1694(94)02674-Z PG 16 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA RH480 UT WOS:A1995RH48000013 ER PT J AU UNDERWOOD, JH PARKER, AP AF UNDERWOOD, JH PARKER, AP TI FATIGUE LIFE ANALYSES AND TESTS FOR THICK-WALL CYLINDERS INCLUDING EFFECTS OF OVERSTRAIN AND AXIAL GROOVES SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT Pressure Vessels and Piping Conference CY JUN 19-23, 1994 CL MINNEAPOLIS, MN AB A fracture mechanics-based fatigue life analysis was developed for overstrained, pressurized thick-wall cylinders with one or several semi-elliptical-shaped axial grooves at the inner diameter. The fatigue life for a crack initiating at the root of the groove was calculated for various cylinder, groove, and crack configurations and for different material yielding conditions. Comparisons were made with fatigue crack growth and laboratory life results from A723 thick-wall cylinders, in which cannon firing rests were first performed to produce axial erosion grooves; followed by cyclic hydraulic pressurization to failure in the laboratory. The life analysis, with an initial crack size based on the expected pre-existing defects, gave a good description of the crack growth and fatigue life of the tests for cylinders with and without grooves. General fatigue life calculations summarized important material and configurational effects on the fatigue life design of overstrained cylinders, including effects of material yield strength, cylinder diameter ratio, stress concentration factor, and initial crack size. C1 NORTHUMBRIA UNIV,FAC ENGN SCI & TECHNOL,NEWCASTLE TYNE,TYNE & WEAR,ENGLAND. RP UNDERWOOD, JH (reprint author), USA,ARMAMENT RES,CTR DEV & ENGN,WATERVLIET,NY 12189, USA. NR 10 TC 16 Z9 16 U1 0 U2 0 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 1995 VL 117 IS 3 BP 222 EP 226 DI 10.1115/1.2842115 PG 5 WC Engineering, Mechanical SC Engineering GA RV566 UT WOS:A1995RV56600004 ER PT J AU CALVERLEY, MJ KONOPKA, KE AF CALVERLEY, MJ KONOPKA, KE TI PRECISE TRIMMING OF SOFT LINING MATERIALS WITH A HOT INSTRUMENT SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Letter C1 USA,DENT CORPS,BROOKE ARMY MED CTR,FT SAM HOUSTON,TX. RP CALVERLEY, MJ (reprint author), UNIV TEXAS,HLTH SCI CTR,SCH DENT,DEPT PROSTHODONT,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. NR 2 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD AUG PY 1995 VL 74 IS 2 BP 202 EP 203 DI 10.1016/S0022-3913(05)80187-8 PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA RL803 UT WOS:A1995RL80300014 PM 8537930 ER PT J AU MCCLEAN, MD CLAY, JL AF MCCLEAN, MD CLAY, JL TI ACTIVATION OF LIP MOTOR UNITS WITH VARIATIONS IN SPEECH RATE AND PHONETIC STRUCTURE SO JOURNAL OF SPEECH AND HEARING RESEARCH LA English DT Article DE LIP; MOTOR UNIT; SPEECH RATE; PHONETIC; FACIAL ID VOLUNTARY MOVEMENT; MUSCLE-ACTIVITY; CORTEX; RECRUITMENT; DIRECTION AB The purpose of this study was to describe the activation characteristics of lip-muscle single motor units in relation to speech rate and phonetic structure. Repeated experiments were carried out an three adult subjects from whom recordings of lower lip EMG and two-dimensional displacement were obtained. Single motor unit recordings were obtained from the orbicularis oris inferior (OOI), depressor labii inferior (DLI), and menta[is (MENT) muscles. Subjects' tasks involved repeating CV syllables at 1 to 4 syllables per second (syl/sec). The distribution of interspike intervals and corresponding firing rates were obtained on 11 motor units. The firing rates of OOI and MENT motor units increased as syllable rate changed from 1 to 3 syl/sec, but firing rates tended to be equivalent at 3 and 4 syl/sec. DLI and tonic motor units showed little or no modulation in their firing rates with speech rate. Firing rate data and related observations on lip movement and EMG spike count levels suggest that distinct neuromechanical processes control lip movements at low and high speech rates. Both kinematic and EMG data support the expectation that phonetic structure has its greatest effects on lip opening compared to lip closing movements in CV syllables. OOI and MENT activation levels tended to be highest for /p/ productions compared to /w/ and /f/. This may be related to the requirements for complete lip closure and elevated levels of intraoral pressure for production of /p/. RP MCCLEAN, MD (reprint author), WALTER REED ARMY MED CTR,CTR AUDIOL & SPEECH,WASHINGTON,DC 20307, USA. NR 32 TC 11 Z9 11 U1 1 U2 1 PU AMER SPEECH-LANG-HEARING ASSN PI ROCKVILLE PA 10801 ROCKVILLE PIKE RD, ROCKVILLE, MD 20852-3279 SN 0022-4685 J9 J SPEECH HEAR RES JI J. Speech Hear. Res. PD AUG PY 1995 VL 38 IS 4 BP 772 EP 782 PG 11 WC Language & Linguistics; Rehabilitation SC Linguistics; Rehabilitation GA RM866 UT WOS:A1995RM86600004 PM 7474971 ER PT J AU GROSSO, NP VANDAM, BE AF GROSSO, NP VANDAM, BE TI TOTAL COCCYGECTOMY FOR THE RELIEF OF COCCYGODYNIA - A RETROSPECTIVE REVIEW SO JOURNAL OF SPINAL DISORDERS LA English DT Article DE COCCYGODYNIA; COCCYGECTOMY AB Nine of 10 patients operated on by a single surgeon were studied. Hospital records. radiographs, and a postal survey were used. Follow-up averaged 56 months. Age at operation averaged 32.5 years. There were six males and three females. Symptoms had been present for 7 months to 14 years and all patients failed a course of non-operative therapy. All patients underwent a total coccygectomy by subperiosteal dissection through a longitudinal midline incision. There was one postoperative wound infection. All patients were satisfied with the surgical scars. Three patients reported ''complete'' pain relief, five reported ''marked improvement,'' and one was ''slightly improved.'' All nine patients were satisfied with the operation and would choose to have the surgery again. RP GROSSO, NP (reprint author), WALTER REED ARMY MED CTR,DEPT ORTHOPAED,7100 GEORGIA AVE,WASHINGTON,DC 20307, USA. NR 0 TC 26 Z9 28 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0895-0385 J9 J SPINAL DISORD JI J. Spinal Disord. PD AUG PY 1995 VL 8 IS 4 BP 328 EP 330 PG 3 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA RR226 UT WOS:A1995RR22600012 PM 8547776 ER PT J AU DOUGLAS, TH CONNELLY, RR MCLEOD, DG ERICKSON, SJ BARREN, R MURPHY, GP AF DOUGLAS, TH CONNELLY, RR MCLEOD, DG ERICKSON, SJ BARREN, R MURPHY, GP TI EFFECT OF EXOGENOUS TESTOSTERONE REPLACEMENT ON PROSTATE-SPECIFIC ANTIGEN AND PROSTATE-SPECIFIC MEMBRANE ANTIGEN LEVELS IN HYPOGONADAL MEN SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE ANDROGENS; TUMOR MARKERS; HYPOGONADISM; PROSTATE CANCER ID CELL-LINE; HYPERPLASIA AB Previous studies have suggested that serum prostate-specific antigen (PSA) levels are under androgenic influence, especially in patients with adenocarcinoma of the prostate. PSMA (prostate-specific membrane antigen) is thought to reflect hormonal or clonal resistance or an independence with respect to testosterone regulation. The influence of testosterone on serum PSA expression in normal men is not clear. We studied the effect of exogenous testosterone administration on the serum levels of PSA and PSMA in hypogonadal men. Serial serum PSA, serum PSMA by Western blot, and serum total testosterone levels were obtained at intervals of every 2-4 weeks in 10 hypogonadal men undergoing treatment with exogenous testosterone, delivered as testosterone enanthate injection or by testosterone patch. Linear and quadratic orthogonal polynomial scores were calculated for PSMA, PSA, and testosterone. A 2-tailed, paired t-test failed to demonstrate a significant correlation between serum PSA (linear P = 0.432, quadratic P = 0.290) or PSMA (linear P = 0.162, quadratic P = 0.973) and serum testosterone levels. This study suggests that in hypogonadal men, neither PSMA nor PSA expression is testosterone-dependent, (C) 1995 Wiley-Liss, Inc. C1 WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTATE DIS RES,BETHESDA,MD 20814. PACIFIC NW CANC FDN,DIV CANC RES,SEATTLE,WA. NR 16 TC 23 Z9 23 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD AUG PY 1995 VL 59 IS 4 BP 246 EP 250 DI 10.1002/jso.2930590410 PG 5 WC Oncology; Surgery SC Oncology; Surgery GA RQ287 UT WOS:A1995RQ28700009 PM 7543173 ER PT J AU ZHENG, JP CYGAN, PJ JOW, TR AF ZHENG, JP CYGAN, PJ JOW, TR TI HYDROUS RUTHENIUM OXIDE AS AN ELECTRODE MATERIAL FOR ELECTROCHEMICAL CAPACITORS SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID SURFACE AB The hydrous ruthenium oxide has been formed by a sol-gel process. The precursor was obtained by mixing aqueous solutions of RuCl3 . xH(2)O and alkalis. The hydrous ruthenium oxide powder was obtained by annealing the precursor at low temperatures. The crystalline structure and the electrochemical properties of the powder have been studied as a function of the annealing temperature. At lower annealing temperatures the powder is in an amorphous phase with a high specific capacitance. Specific capacitance as high as 720 F/g was measured for the powder formed at 150 degrees C. When the annealing temperature exceeded 175 degrees C, the crystalline phase was formed, and the specific capacitance dropped rapidly. The surface area of the powder and the resistivity of the pellet made from these powders have also been studied. The specific surface area and the resistivity decreased as the annealing temperature increased. A capacitor was made with electrodes comprised of hydrous ruthenium oxide and H2SO4 electrolyte. The energy density of 96 J/g (or 26.7 Wh/kg), based on electrode material only was measured for the cell using hydrous ruthenium oxide electrodes. It was also found that hydrous ruthenium oxide is stable in H2SO4 electrolyte. RP ZHENG, JP (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 24 TC 1170 Z9 1258 U1 19 U2 184 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD AUG PY 1995 VL 142 IS 8 BP 2699 EP 2703 DI 10.1149/1.2050077 PG 5 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA RN053 UT WOS:A1995RN05300036 ER PT J AU OFFNER, PJ OGURA, H JORDAN, BS PRUITT, BA CIOFFI, WG AF OFFNER, PJ OGURA, H JORDAN, BS PRUITT, BA CIOFFI, WG TI EFFECTS OF INHALED NITRIC-OXIDE ON RIGHT-VENTRICULAR FUNCTION IN ENDOTOXIN-SHOCK SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 54th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 29-OCT 01, 1994 CL SAN DIEGO, CA SP Amer Assoc Surg Trauma ID HYPOXIC PULMONARY VASOCONSTRICTION; RESPIRATORY-DISTRESS SYNDROME; SEPTIC SHOCK; GAS-EXCHANGE; DYSFUNCTION; HYPERTENSION; DISEASE; LUNG; VASODILATION; SEPSIS AB Sepsis has been shown to cause right ventricular (RV) dysfunction, which may be related to pulmonary hypertension and increased RV afterload. This study evaluates the effects of inhaled nitric oxide (NO), a selective pulmonary vasodilator, on RV function in a porcine model of endotoxemia, After an infusion of Escherichia coli lipopolysaccharide (LPS; 200 mu g/kg), animals were resuscitated with saline (1 mL/kg/min) and observed for 3 hours while being mechanically ventilated (Fio(2) = 0.6, tidal volume = 12 mL/kg, and peak end-expiratory pressure = 5 cm H2O), The LPS group (n = 5) received no additional treatment, The NO group (n = 5) received inhaled NO (40 ppm) for the last 2 hours, The control group (n = 5) received only saline without LPS. Hemodynamic data and blood gases were collected hourly for 3 hours. LPS resulted in pulmonary hypertension and RV dysfunction as indexed by a decreased RV ejection fraction and increased RV end-diastolic volume, Inhaled NO significantly decreased pulmonary hypertension and significantly increased RV ejection fraction and oxygen delivery without adverse effects, In conclusion, inhaled NO significantly improved pulmonary hypertension and RV dysfunction in a porcine model of endotoxemia and should be a useful therapeutic modality in selected septic patients. C1 BROOKE ARMY MED CTR,DEPT SURG,CRIT CARE SERV,FT SAM HOUSTON,TX. USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 30 TC 17 Z9 17 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Inf. Crit. Care PD AUG PY 1995 VL 39 IS 2 BP 179 EP 186 DI 10.1097/00005373-199508000-00001 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA RT208 UT WOS:A1995RT20800001 PM 7674383 ER PT J AU CHU, CS MCMANUS, AT MATYLEVICH, NP MASON, AD PRUITT, BA AF CHU, CS MCMANUS, AT MATYLEVICH, NP MASON, AD PRUITT, BA TI ENHANCED SURVIVAL OF AUTOEPIDERMAL ALLODERMAL COMPOSITE GRAFTS IN ALLOSENSITIZED ANIMALS BY USE OF SILVER-NYLON DRESSINGS AND DIRECT-CURRENT SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 54th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 29-OCT 01, 1994 CL SAN DIEGO, CA SP Amer Assoc Surg Trauma AB Objective: Observe the effect of silver-nylon (SN) dressing and direct electric current on healing of meshed autoepidermal/allodermal composite skin grafts (MICSGs) in allosensitized rats, Materials and Methods: MCSGs were placed on experimental animals 28 to 30 days after placement of sensitizing allografts, MCSGs and control allografts were covered,vith either Vaseline gauze (VG) or SN; direct current, 40 mu A, was applied for 5 days to some of the SN-dressed wounds (SNDCs). Measurements and Main Results: Second set rejection of MCSG was not observed, SN- and SNDC-treated grafts showed expansion of the meshed autoepidermis with complete epithelialization within 3 weeks, VG-covered wounds developed areas of open granulation and were not completely epithelialized at 3 months, Both SN and SNDC reduced wound contraction when compared to VG (SN versus VG p < 0.02, SNDC versus VG p < 0.008), MCSG was found to be of low alloantigenicity in that it did not induce second set rejection of subsequent skin allograft, Conclusions: SN dressings enhanced survival of meshed composite skin grafts. RP CHU, CS (reprint author), USA,INST SURG RES,LIBRARY BRANCH,2322 HARNEY RD,FT SAM HOUSTON,TX 78234, USA. NR 6 TC 13 Z9 13 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Inf. Crit. Care PD AUG PY 1995 VL 39 IS 2 BP 273 EP 278 DI 10.1097/00005373-199508000-00014 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA RT208 UT WOS:A1995RT20800014 PM 7674396 ER PT J AU OFFNER, PJ ROBERTSON, FM PRUITT, BA AF OFFNER, PJ ROBERTSON, FM PRUITT, BA TI EFFECTS OF NITRIC-OXIDE SYNTHASE INHIBITION ON REGIONAL BLOOD-FLOW IN A PORCINE MODEL OF ENDOTOXIC-SHOCK SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID CARDIAC-OUTPUT; RELAXING FACTOR; SEPSIS; PIGS; PRESSURE; RATS; OXYGENATION; ISCHEMIA; DAMAGE AB The results of early studies suggest that nitric oxide (NO) synthesis inhibition may be therapeutic in sepsis, but recent data indicate that NO inhibition may be harmful, This study investigates the effects of NO synthesis inhibition with N-nitro-L-arginine methyl ester (NAME) on regional blood flow following endotoxemia, Anesthetized, instrumented swine were randomly divided into four groups, Controls received normal saline resuscitation (NSR) at 1 cc/kg/min beginning at T-0. The lipopolysaccharide group (LPS) received NSR and Escherichia coli LPS, 200 mu g/kg at T-0, The LPS + NAME group received NSR and LPS at T-0, plus NAME (50 mu g/kg/min) starting at T-1, The NAME group received only NSR and NAME, Hemodynamic data, regional blood flow, and gastric intramucosal pH (pH(i)) were measured hourly, LPS increased renal and carotid blood flow consistent with a hyperdynamic state, Mesenteric blood flow was decreased, Treatment of endotoxic animals with NAME decreased renal and carotid blood flow, Mesenteric blood flow and gastric pH(i) were improved by NAME. NO inhibition in endotoxic shock results in decreased carotid and renal blood flow, by decreasing cardiac output, Mesenteric blood flow and perfusion were improved; however, this requires further study for validation. C1 BROOKE ARMY MED CTR,DEPT SURG,CRIT CARE SERV,FT SAM HOUSTON,TX 78234. USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 39 TC 29 Z9 29 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Inf. Crit. Care PD AUG PY 1995 VL 39 IS 2 BP 338 EP 343 DI 10.1097/00005373-199508000-00025 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA RT208 UT WOS:A1995RT20800025 PM 7545764 ER PT J AU HEIDENBERG, HB SESTERHENN, IA GADDIPATI, JP WEGHORST, CM BUZARD, GS MOUL, JW SRIVASTAVA, S AF HEIDENBERG, HB SESTERHENN, IA GADDIPATI, JP WEGHORST, CM BUZARD, GS MOUL, JW SRIVASTAVA, S TI ALTERATION OF THE TUMOR-SUPPRESSOR GENE P53 IN A HIGH FRACTION OF HORMONE-REFRACTORY PROSTATE-CANCER SO JOURNAL OF UROLOGY LA English DT Article DE PROSTATIC NEOPLASMS; GENES, P53; PROTEIN P53; GENES, SUPPRESSOR, TUMOR ID LI-FRAUMENI SYNDROME; PRONE FAMILY; CARCINOMA; MUTATIONS; EXPRESSION; MUTANT; ACCUMULATION; PROGRESSION; GROWTH; CELLS AB Purpose: We studied the role of p53 tumor suppressor gene alteration in prostate cancer progression by demonstrating a difference in abnormal p53 findings between early and hormone refractory disease. Materials and Methods: The study included p53 immunohistochemistry of 26 archival transurethral resection specimens from patients with radiation recurrent and hormone refractory disease, 27 untreated primary tumors and 8 untreated metastatic lesions. p53 mutation analysis of tumor deoxyribonucleic acid (DNA) from microdissected specimens was done by cold single strand conformational polymorphism and DNA sequencing. Results: Elevated p53 protein was present in 16 of 17 hormone refractory specimens (94%), 4 of 8 untreated metastatic tumors (50%) and 6 of 27 primary untreated tumors (22%). DNA analysis of representative specimens with elevated p53 confirmed p53 gene alterations in 9 of 11 cases (82%). Conclusions: Our study revealed a clear progression of increased p53 alteration from untreated primary to hormone refractory disease (p<0.00005). C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. ARMED FORCES INST PATHOL,WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL,WASHINGTON,DC 20306. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTRATE DIS RES,FREDERICK,MD. NCI,COMPARAT CARCINOGENESIS LAB,FREDERICK,MD 21701. NCI,FREDERICK CANC RES & DEV CTR,PRI DYNCORP,BCDP,FREDERICK,MD 21702. NR 36 TC 138 Z9 138 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1995 VL 154 IS 2 BP 414 EP 421 DI 10.1016/S0022-5347(01)67065-4 PN 1 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA RJ050 UT WOS:A1995RJ05000023 PM 7609105 ER PT J AU SOLOWAY, MS SHARIFI, R WAJSMAN, Z MCLEOD, D WOOD, DP PURASBAEZ, A AF SOLOWAY, MS SHARIFI, R WAJSMAN, Z MCLEOD, D WOOD, DP PURASBAEZ, A TI RANDOMIZED PROSPECTIVE-STUDY COMPARING - RADICAL PROSTATECTOMY ALONE VERSUS RADICAL PROSTATECTOMY PRECEDED BY ANDROGEN BLOCKADE IN CLINICAL STAGE B2 (T2BNXMO) PROSTATE-CANCER SO JOURNAL OF UROLOGY LA English DT Article DE PROSTATIC NEOPLASMS; NEOPLASM ANTIGENS; PROSTATECTOMY; ANDROGENS; HORMONES ID NEOADJUVANT HORMONAL DEPRIVATION; LYMPH-NODE METASTASES; CAPSULAR PENETRATION; LEUPRORELIN ACETATE; RADIATION-THERAPY; FOLLOW-UP; PROGRESSION; RADIOTHERAPY; ANTIGEN; TUMOR AB Purpose: Nonrandomized clinical trials have suggested that preoperative androgen deprivation can decrease the likelihood of positive surgical margins in patients with clinically localized prostate cancer. A multicenter prospective randomized trial compared radical prostatectomy alone to radical prostatectomy after 3 months of leuprolide acetate depot and flutamide in patients with stage cT2bNxMO prostate cancer and a serum prostate specific antigen level less than 50 ng./ml. Materials and Methods: We randomized 149 patients to undergo androgen deprivation and 138 to undergo lymphadenectomy with (137) or without (1) prostatectomy. Of the 154 patients randomized to the surgery alone group 144 underwent pelvic node dissection with (138) or without (6) prostatectomy. Results: There was no statistically significant difference between the 2 groups in operating time, blood loss, need for transfusion, postoperative morbidity or length of hospital stay. There were 4 rectal and 2 ureteral injuries in the surgery alone group and none in the pretreatment group (p<0.05). Patients who received androgen deprivation preoperatively had a significantly lower rate of capsule penetration (47% versus 78%, p<0.001), positive surgical margins (18% versus 48%, p<0.001) and tumor at the urethral margin (6% versus 17%, p<0.01). Conclusions: Long-term followup data will be needed to determine whether there will be a lower incidence of biochemical relapse as determined by prostate specific antigen, local recurrence or metastasis, with an improvement in patient survival. C1 UNIV FLORIDA,DEPT UROL,GAINESVILLE,FL. UNIV ILLINOIS,DEPT UROL,CHICAGO,IL. WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC. UNIV KENTUCKY,DEPT UROL,LEXINGTON,KY. UNIV PUERTO RICO,DEPT UROL,HATO REY,PR. RP SOLOWAY, MS (reprint author), UNIV MIAMI,SCH MED,DEPT UROL,MIAMI,FL 33152, USA. NR 31 TC 284 Z9 289 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1995 VL 154 IS 2 BP 424 EP 428 DI 10.1016/S0022-5347(01)67067-8 PN 1 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA RJ050 UT WOS:A1995RJ05000025 PM 7541859 ER PT J AU SCHENKMAN, NS SESTERHENN, IA WASHINGTON, L TONG, YA WEGHORST, CM BUZARD, GS SRIVASTAVA, S MOUL, JW AF SCHENKMAN, NS SESTERHENN, IA WASHINGTON, L TONG, YA WEGHORST, CM BUZARD, GS SRIVASTAVA, S MOUL, JW TI INCREASED P53 PROTEIN DOES NOT CORRELATE TO P53 GENE-MUTATIONS IN MICRODISSECTED HUMAN TESTICULAR GERM-CELL TUMORS SO JOURNAL OF UROLOGY LA English DT Article DE TESTICULAR NEOPLASMS; GENES, P53; PROTEIN P53; POLYMORPHISM, SINGLE STRANDED CONFORMATIONAL ID SUPPRESSOR GENE; BREAST-CANCER; PHOSPHOPROTEIN; EXPRESSION; TESTIS; LINES AB Purpose: To determine if primary testicular germ cell tumors that overexpress p53 tumor suppressor gene protein have p53 gene mutations. Materials and Methods: We examined 30 primary testicular tissues from 26 patients representing two groups, Group one consisted of eleven cases (6 nonseminomatous germ cell tumors and 5 seminomas) in which tissue samples for DNA analysis were microdissected from paraffin block regions with elevated immunohistochemical staining for p53 protein, Group two consisted of 19 testis tumor tissues which had been fresh frozen and were chosen to correspond to archival tissue specimens exhibiting elevated levels of p53 protein. The DNA was extracted from these tissues and subjected to exon specific amplification by polymerase chain reaction (PCR) and cold single-strand conformation polymorphism (Cold SSCP) analysis. Results: In these cases with elevated p53 protein, no p53 gene exon 5-8 mutations were detected except 1 seminoma with a codon 140 silent mutation (no protein alteration). Conclusions: Testicular tumors appear to exhibit elevated levels of wild-type p53 protein, the significance of which is yet to be elucidated. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTATE DIS RES,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. NCI,FCRDC,COMPARAT CARCINOGENESIS LAB,FREDERICK,MD. PRI DYNCORP,BCDP,FREDERICK,MD. NR 39 TC 59 Z9 59 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1995 VL 154 IS 2 BP 617 EP 621 DI 10.1016/S0022-5347(01)67122-2 PN 1 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA RJ050 UT WOS:A1995RJ05000079 PM 7609148 ER PT J AU RUSHTON, HG BELMAN, AB ZAONTZ, M SKOOG, SJ SIHELNIK, S AF RUSHTON, HG BELMAN, AB ZAONTZ, M SKOOG, SJ SIHELNIK, S TI RESPONSE TO DESMOPRESSIN AS A FUNCTION OF URINE OSMOLALITY IN THE TREATMENT OF MONOSYMPTOMATIC NOCTURNAL ENURESIS - A DOUBLE-BLIND PROSPECTIVE-STUDY SO JOURNAL OF UROLOGY LA English DT Article DE ENURESIS; DESMOPRESSIN ID ENURETICS AB To determine if urine osmolality parameters can predict whether children with primary monosymptomatic nocturnal enuresis will respond to desmopressin, we conducted a prospective, double-blind, placebo-controlled study in 96 children 8 to 14 years old. Following a 2-week baseline screening interval patients with at least 6 of 14 wet nights were randomized to double-blind regimens of desmopressin or placebo. Urine specimens for osmolality were collected at 6 p.m. and 6 a.m. on 3 consecutive days during the baseline and the 2, 14-day treatment periods. A significantly greater proportion of desmopressin treated children had an excellent (2 or fewer wet nights in 14 days) or good (greater than 50% reduction in wet nights) response compared with placebo treated children (p = 0.004 and p = 0.002 for treatment periods 1 and 2, respectively). Children treated with desmopressin reported a significantly lower number of wet nights than placebo treated children during both treatment periods (p = 0.0258 and p = 0.0136, respectively). Children treated with desmopressin had a significantly higher 6 a.m. urine osmolality during both treatment periods and a higher 6 a.m.-to-6 p.m. osmolality ratio (p = 0.004) in the first treatment period compared with the placebo group. Within the desmopressin treatment group clinical responders had a higher 6 a.m. urine osmolality and 6 a.m.-to-6 p.m. urine osmolality ratio than nonresponders during both treatment periods but these differences did not achieve statistical significance, In conclusion, treatment with desmopressin is associated with a significant decrease in the number of wet nights, and a significant increase in nocturnal urine osmolality and nocturnal/diurnal urine osmolality ratios. However, clinical response was not predictable based on baseline or treatment osmolality parameters. C1 WALTER REED ARMY MED CTR,CHILDRENS NATL MED CTR,WASHINGTON,DC. COOPER MED CTR,CAMDEN,NJ. NR 14 TC 21 Z9 21 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1995 VL 154 IS 2 BP 749 EP 753 DI 10.1016/S0022-5347(01)67153-2 PN 2 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA RJ051 UT WOS:A1995RJ05100027 PM 7609170 ER PT J AU BOMALASKI, MD TEAGUE, JL BROOKS, B AF BOMALASKI, MD TEAGUE, JL BROOKS, B TI THE LONG-TERM IMPACT OF UROLOGICAL MANAGEMENT ON THE QUALITY-OF-LIFE OF CHILDREN WITH SPINA-BIFIDA SO JOURNAL OF UROLOGY LA English DT Article DE MENINGOMYELOCELE; URINARY INCONTINENCE; SEX BEHAVIOR; EMPLOYMENT; EDUCATION ID CONDUIT URINARY-DIVERSION; MYELOMENINGOCELE; CATHETERIZATION AB To evaluate the integration of children with spina bifida into adult society and identify important urological factors 20 female and 18 male spina bifida patients older than 18 years were evaluated with respect to urological management and complications. A detailed questionnaire concerning educational achievements, living arrangements, employment and interpersonal relationships was completed and compared to similar data obtained from the 1990 United States census. Educational achievement and living arrangements for most patients were comparable to age matched peers in the general population and were independent of gender or method of urinary management. The only statistically significant factor related to a positive outcome was female gender in the areas of employment (p < 0.014) and sexual relationships (p < 0.005). Female spina bifida patients adapted better to adult society than their male counterparts. Intestinal urinary conduits were detrimental to long-term renal function. C1 BROOKE ARMY MED CTR,SAN ANTONIO,TX. RP BOMALASKI, MD (reprint author), WILFORD HALL USAF MED CTR,DEPT UROL,SAN ANTONIO,TX 78236, USA. NR 12 TC 19 Z9 19 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1995 VL 154 IS 2 BP 778 EP 781 DI 10.1016/S0022-5347(01)67161-1 PN 2 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA RJ051 UT WOS:A1995RJ05100035 PM 7609178 ER PT J AU ALLEN, PJ GILLESPIE, DL REDFIELD, RR GOMEZ, ER AF ALLEN, PJ GILLESPIE, DL REDFIELD, RR GOMEZ, ER TI LOWER-EXTREMITY LYMPHEDEMA CAUSED BY ACQUIRED IMMUNE-DEFICIENCY SYNDROME-RELATED KAPOSIS-SARCOMA - CASE-REPORT AND REVIEW OF THE LITERATURE SO JOURNAL OF VASCULAR SURGERY LA English DT Note ID SYNDROME AIDS; THERAPY; COMPRESSION; TRIAL AB A case of severe lymphedema of the lower extremity caused by obstruction by human immunodeficiency virus-associated Kaposi's sarcoma is presented. A review of the signs and symptoms of obstructive lymphedema and Kaposi's sarcoma is provided. Early recognition of this clinical entity may allow use of simple preventative measures and help to avoid this life- and limb-threatening situation. C1 WALTER REED ARMY MED CTR,DEPT VASC SURG,PERIPHERAL VASC SURG SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT INFECT DIS,WASHINGTON,DC 20307. OI Gillespie, David/0000-0002-4378-9465 NR 16 TC 6 Z9 6 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD AUG PY 1995 VL 22 IS 2 BP 178 EP 181 DI 10.1016/S0741-5214(95)70114-1 PG 4 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA RP701 UT WOS:A1995RP70100009 PM 7637119 ER PT J AU COLGIN, LMA NIELSEN, RE TUCKER, FS OKERBERG, CV AF COLGIN, LMA NIELSEN, RE TUCKER, FS OKERBERG, CV TI CASE-REPORT OF LISTERIAL KERATOCONJUNCTIVITIS IN HAIRLESS GUINEA-PIGS SO LABORATORY ANIMAL SCIENCE LA English DT Note ID MONOCYTOGENES C1 USA,INST CHEM RES,VET MED & SURG BRANCH,ABERDEEN PROVING GROUND,MD 21010. USA,INST CHEM RES,DIV VET MED & LAB RESOURCES,ABERDEEN PROVING GROUND,MD 21010. RP COLGIN, LMA (reprint author), USA,INST CHEM RES,DIV PATHOPHYSIOL,COMPARAT PATHOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 11 TC 5 Z9 5 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD AUG PY 1995 VL 45 IS 4 BP 435 EP 436 PG 2 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA RR166 UT WOS:A1995RR16600020 PM 7474886 ER PT J AU BURGESS, EB AF BURGESS, EB TI UNDER GROUND - DALY,M SO LIBRARY JOURNAL LA English DT Book Review RP BURGESS, EB (reprint author), USA,TRALINET CTR,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD AUG PY 1995 VL 120 IS 13 BP 115 EP 115 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RN627 UT WOS:A1995RN62700282 ER PT J AU THEVENOT, MM KRAUS, NC AF THEVENOT, MM KRAUS, NC TI LONGSHORE SAND WAVES AT SOUTHAMPTON BEACH, NEW-YORK - OBSERVATION AND NUMERICAL-SIMULATION OF THEIR MOVEMENT SO MARINE GEOLOGY LA English DT Article ID COAST AB This paper describes measurements and numerical simulations of the movement of longshore sand waves observed at Southampton Beach, Long Island, New York. These large morphologic features are created by periodic opening of a small inlet and subsequent welding of its ebb shoal to the beach. Longshore sand waves are wave-like forms that maintain identity while moving along the shore and represent a simple type of collective sediment movement or large-scale coastal behavior. Despite being described as early as 1939, few measurements of longshore sand waves have been made, and their dynamic behavior is not well understood. Eleven longshore sand waves were identified along Southampton Beach and have an average length of 0.75 km and an amplitude of 40 m. Migration speed was greatest under winter wave action and reached an average 1.09 km year(-1) and yearly average speed including summer calms was a much lower 0.35 km year(-1). During a 16-month observation period, the longshore sand waves did not disperse during their steady migration westward in the direction of predominant wave incidence, and longer waves moved faster than those with smaller wavelengths. A numerical model of shoreline change including both standard particulate longshore sand transport and a component describing migration of a longshore sand wave is developed in which the velocity of the wave is related to the calculated longshore discharge of water. The model shows wave refraction to be an important mechanism contributing to the longevity of longshore sand waves, acting to retard the otherwise expected diffusion. Model calculations of the migration of a single longshore sand wave agree quantitatively with the observations. C1 TEXAS A&M UNIV,CONRAD BLUCHER INST SURVEYING & SCI,CORPUS CHRISTI,TX 78412. RP THEVENOT, MM (reprint author), USA,WATERWAYS EXPT STN,COASTAL ENGN RES CTR,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 27 TC 39 Z9 39 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0025-3227 J9 MAR GEOL JI Mar. Geol. PD AUG PY 1995 VL 126 IS 1-4 BP 249 EP 269 DI 10.1016/0025-3227(95)00081-9 PG 21 WC Geosciences, Multidisciplinary; Oceanography SC Geology; Oceanography GA RY155 UT WOS:A1995RY15500015 ER PT J AU HOSPENTHAL, DR BYRD, JC WEISS, RB AF HOSPENTHAL, DR BYRD, JC WEISS, RB TI SUCCESSFUL TREATMENT OF INVASIVE ASPERGILLOSIS COMPLICATING PROLONGED TREATMENT-RELATED NEUTROPENIA IN ACUTE MYELOGENOUS LEUKEMIA WITH AMPHOTERICIN-B LIPID COMPLEX SO MEDICAL AND PEDIATRIC ONCOLOGY LA English DT Article DE ASPERGILLOSIS; LIPOSOME; AMPHOTERICIN B; LEUKEMIA; NEUTROPENIA ID SYSTEMIC FUNGAL-INFECTIONS; THERAPY; DEOXYCHOLATE AB Herein we report the successful treatment of invasive aspergillosis with the liposomal amphotericin B (AMB) formulation, Amphotericin and Lipid Complex (ABLC(TM)). This investigational compound was employed in a 50-year-old patient with acute myelomonocytic leukemia complicated by prolonged, treatment-induced granulocytopenia and documented Aspergillus flavus sinusitis with signs of disseminated aspergillosis. The patient demonstrated radiographic signs of pulmonary aspergillosis and biochemical signs of hepatic involvement that were resistant to a 23 day course of conventional AMB (Fungizone(R)) therapy. Following therapy with ABLC(TM) her fever abated, her chest X-ray findings improved, and her hepatic function tests improved with eventual resolution. (C) 1995 Wiley-Liss, Inc. C1 WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307. NR 18 TC 22 Z9 22 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-1532 J9 MED PEDIATR ONCOL JI Med. Pediatr. Oncol. PD AUG PY 1995 VL 25 IS 2 BP 119 EP 122 DI 10.1002/mpo.2950250214 PG 4 WC Oncology; Pediatrics SC Oncology; Pediatrics GA RD828 UT WOS:A1995RD82800013 PM 7603397 ER PT J AU LANDE, G AF LANDE, G TI MILITARY SHOPLIFTING SO MILITARY MEDICINE LA English DT Article AB Shoplifting is a crime generally attributed to women. This article describes a population of mostly male active duty military shoplifters, Several cases are presented and discussed in detail. Shoplifting, and the psychiatric theories explaining the behavior, are placed in perspective with a literature review, The significance of shoplifting in the military is discussed by examining the law, appellate opinions, and the range of punishments. The article concludes by providing suggestions for conducting a medico-legal evaluation. RP LANDE, G (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1995 VL 160 IS 8 BP 404 EP 407 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA RP795 UT WOS:A1995RP79500010 PM 8524467 ER PT J AU LUSTER, SH HUGHBANKS, JC AF LUSTER, SH HUGHBANKS, JC TI FROM MOUTH TO HAND - APPLYING DENTAL TECHNOLOGY TO HAND REHABILITATION SO MILITARY MEDICINE LA English DT Note AB Low-temperature thermoplastic and plaster splints are frequently used in the treatment of tendon and ligament injuries of the fingers. Splints made from these materials are problematic in that they degrade with exposure to the chemicals and physical stresses found in the field environment. Chromium-based alloys, commonly used in dental appliances, have been found suitable for use in the fabrication of finger splints. Splints made from these materials are lightweight, durable, relatively inexpensive, and can withstand the rigors of the field environment. Durable splints can enhance clinical outcome and decrease soldier ''down time'' from repeated sick call visits for splint repair. RP LUSTER, SH (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,OCCUPAT THERAPY SECT,FT GORDON,GA, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1995 VL 160 IS 8 BP 420 EP 421 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA RP795 UT WOS:A1995RP79500014 PM 8524471 ER PT J AU TANG, TL KIANG, JG COTE, TE COX, BM AF TANG, TL KIANG, JG COTE, TE COX, BM TI ANTISENSE OLIGODEOXYNUCLEOTIDE TO THE G(I2) PROTEIN ALPHA-SUBUNIT SEQUENCE INHIBITS AN OPIOID-INDUCED INCREASE IN THE INTRACELLULAR FREE CALCIUM-CONCENTRATION IN ND8-47 NEUROBLASTOMA X DORSAL-ROOT GANGLION HYBRID-CELLS SO MOLECULAR PHARMACOLOGY LA English DT Note ID NUCLEOTIDE-BINDING PROTEIN; ADENYLATE-CYCLASE; GENE-EXPRESSION; RECEPTOR; CHANNELS; NEURONS; MODULATION; CULTURES AB In ND8-47 cells, a neuroblastoma x dorsal root ganglion hybrid cell line, activation of delta-opioid receptors induced an increase in the intracellular free calcium concentration ([Ca2+](i)) through dihydropyridine-sensitive calcium channels. This effect was mediated by pertussis toxin-sensitive G proteins. The G protein alpha subunits alpha(12), alpha(13), alpha(q), and alpha(s) were detected using Western blots, whereas alpha(o) and alpha(11) were not found in ND8-47 cell membranes. To identify the specific G protein alpha subunit(s) responsible for the increase in [Ca2+](i), we treated ND8-47 cells with antisense oligadeoxynucleotides (AS) complementary to the mRNA for each G protein alpha subunit (alpha(12), alpha(13), or alpha(s)), at a concentration of 10 mu M, for up to 6 days and examined their effects on opioid-induced increases in [Ca2+](i) and on the levels of G protein a subunits. [Ca2+](i) was measured in adherent cells using the fluorescent dye fura-2. Treatment of cells with alpha(12)-AS (10 mu M, for 6 days) resulted in a 73% inhibition of the [D-Ser(2),Leu(5)]-enkephalin-Thr-induced increase in [Ca2+](i). In contrast, pretreatment of cells with alpha(13)-AS (10 mu M, for 6 days) or alpha(s)-AS (10 mu M, for 6 days) had no effect on the [D-Ser(2),Leu(5)]-enkephalin-Thr-induced responses. Western blots indicated that the levels of alpha(12) were decreased when cells were exposed to alpha(12)-AS (10 mu M) for 6 days, whereas the levels of alpha(13), alpha(s), and alpha(q) were not affected by this treatment. Treatment of the cells with alpha(13)-AS or alpha(s)-AS for 6 days significantly reduced alpha(13), or alpha(s) levels, respectively, These results indicate that the opioid-induced increase in [Ca2+](i) in ND8-47 cells is mediated by G(alpha 12). C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV CLIN PHARMACOL,DIV MED,WASHINGTON,DC 20307. FU NIDA NIH HHS [DA03102] NR 31 TC 30 Z9 31 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0026-895X J9 MOL PHARMACOL JI Mol. Pharmacol. PD AUG PY 1995 VL 48 IS 2 BP 189 EP 193 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA RR111 UT WOS:A1995RR11100004 PM 7651350 ER PT J AU MCCANN, UD THORNE, D HALL, M POPP, K AVERY, W SING, H THOMAS, M BELENKY, G AF MCCANN, UD THORNE, D HALL, M POPP, K AVERY, W SING, H THOMAS, M BELENKY, G TI THE EFFECTS OF L-DIHYDROXYPHENYLALANINE ON ALERTNESS AND MOOD IN ALPHA-METHYL-PARA-TYROSINE-TREATED HEALTHY HUMANS - FURTHER EVIDENCE FOR THE ROLE OF CATECHOLAMINES IN AROUSAL AND ANXIETY SO NEUROPSYCHOPHARMACOLOGY LA English DT Article DE CATECHOLAMINES; AROUSAL; MOOD; ANXIETY; AMPT; L-DOPA; CARBIDOPA ID PANIC DISORDER; NORADRENERGIC FUNCTION; PARKINSONS-DISEASE; SLEEP-DEPRIVATION; ATTACKS; AGORAPHOBIA; VOLUNTEERS; COGNITION AB Treatment with alpha-methyl-para-tyrosine (AMPT), a catecholamine synthesis inhibitor, has been shown to produce pronounced increases in sleepiness and mild increases in negative mood and anxiety when administered to healthy male adults. The present study was conducted to ascertain whether these effects of AMPT ave secondary to decreases in brain catecholamines or whether they represent nonspecific drug effects. Forty-one healthy males were randomized to one of four treatment groups. (2) Treatment with AMPT alone (AMPT/placebo); (2) treatment with AMPT plus L-dopa/carbidopa carbidopa (AMPT plus L-dopa/carbidopa); (3) treatment with L-dopa/carbidopa alone (placebo plus L-dopa/carbidopa); or (4) treatment with placebo alone (placebo plus placebo). Repeated measures of alertness, mood, and anxiety were obtained over a three-day period of drug treatment and following drug discontinuation. As before, AMPT treatment led to increased sleepiness. In addition, AMPT treatment led to decreased calmness, increased tension and anger, and a trend for increased depression. Replacement of catecholamine stoves with L-dopa reversed the effects of AMPT and was associated with a more rapid recovery from AMPT's effects. These findings indicate that AMPT's effects on alertness and anxiety are catecholamine-specific. Further, they provide additional evidence that catecholamines are involved in the regulation of normal states of arousal, and they are consistent with the view that brain catecholaminergic dysregulation is involved in pathological anxiety states. C1 WALTER REED ARMY INST RES,DEPT BEHAV BIOL,WASHINGTON,DC. UNIV PITTSBURGH,DEPT PSYCHOL,PITTSBURGH,PA 15260. RP MCCANN, UD (reprint author), NIMH,BIOL PSYCHIAT BRANCH,ANXIETY & AFFECT DISORDERS SECT,BPB,BLDG 10,ROOM 3N-212,BETHESDA,MD 20892, USA. RI Hall, Martica/D-2809-2012 OI Hall, Martica/0000-0003-0642-2098 NR 29 TC 25 Z9 26 U1 0 U2 2 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0893-133X J9 NEUROPSYCHOPHARMACOL JI Neuropsychopharmacology PD AUG PY 1995 VL 13 IS 1 BP 41 EP 52 DI 10.1016/0893-133X(94)00134-L PG 12 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA RN534 UT WOS:A1995RN53400005 PM 8526970 ER PT J AU JACOB, M BOYLE, FS ANTONOVYCH, TT CHAN, JCM AF JACOB, M BOYLE, FS ANTONOVYCH, TT CHAN, JCM TI COMPARISON OF THE BIOLOGICAL EFFECTIVENESS OF CALCITRIOL AND DIHYDROTACHYSTEROL SO NUTRITION RESEARCH LA English DT Article DE 1,25-DIHYDROXYVITAMIN D-3; CALCITRIOL AND DIHYDROTACHYSTEROL ID CHRONIC-RENAL-FAILURE; VITAMIN-D; OSTEODYSTROPHY; CHILDREN; ANALOGS; SYSTEM AB Calcitriol and dihydrotachysterol are both used in clinical practice as treatment for several renal and endocrine conditions. However, despite their routine use, therapeutic dosages and concomitant adverse effects of these medications have yet to be clarified. In our study, a low, high and extreme dosage of calcitriol (20, 60, 120 ng/kg/day) or dihydrotachysterol (15, 45, 90 mu g/kg/day) was administered to six groups of male Sprague Dawley rats for four weeks. The seventh group served as untreated controls. Our results indicated no difference in food intake, weight gain, or total or ionized plasma calcium among treatment groups. Rats receiving 90 mu g/kg/day dihydrotachysterol excreted more calcium than those receiving 120 ng/kg/day calcitriol (p < 0.002). Femur and kidney calcium showed no significant differences for any dosages used of either medication. Mean urine calcium was significantly correlated with ionized plasma calcium (p < 0.006) and kidney calcium (p < 0.02). Light microscopy revealed evidence of calcification in one rat out of six receiving the extreme dose (120 ng/kg/day) of calcitriol and one rat out of six receiving the extreme dose (90 mu g/kg/day) of dihydrotachysterol. These results suggest that serum and urine calcium must be carefully monitored during either form of vitamin D therapy, but no effect on calcium content or histology of the kidneys was observed in the common therapeutic range. C1 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,CHILDRENS MED CTR,DEPT PEDIAT,DIV NEPHROL,RICHMOND,VA 23298. WALTER REED ARMY MED CTR,ARMED FORCES INST PATHOL,WASHINGTON,DC 20015. NR 25 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0271-5317 J9 NUTR RES JI Nutr. Res. PD AUG PY 1995 VL 15 IS 8 BP 1191 EP 1197 DI 10.1016/0271-5317(95)00078-W PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA RL344 UT WOS:A1995RL34400011 ER PT J AU FEENEY, RE ASKEW, EE JEZIOR, DA AF FEENEY, RE ASKEW, EE JEZIOR, DA TI THE DEVELOPMENT AND EVOLUTION OF US ARMY FIELD RATIONS SO NUTRITION REVIEWS LA English DT Review AB Armed conflicts create large masses of personnel that need to be fed nutritious foods in less than favorable conditions. The United States military private industry, and academia continue to work together to develop rations that meet the needs of military personnel who find themselves in varying climates conditions, and geography. C1 USA,ENVIRONM MED RES INST,DIV MIL NUTR,NATICK,MA 01760. RP FEENEY, RE (reprint author), UNIV CALIF DAVIS,DEPT FOOD SCI & TECHNOL,DAVIS,CA 95616, USA. NR 15 TC 0 Z9 0 U1 1 U2 5 PU INT LIFE SCIENCES INST PI LAWRENCE PA 810 EAST 10TH ST SUBSCRIPTION OFFICE, LAWRENCE, KS 66044 SN 0029-6643 J9 NUTR REV JI Nutr. Rev. PD AUG PY 1995 VL 53 IS 8 BP 221 EP 225 PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA RX058 UT WOS:A1995RX05800002 PM 7501306 ER PT J AU MCMILLEN, DK ZABEL, CG ERBACH, PS GREGORY, DA AF MCMILLEN, DK ZABEL, CG ERBACH, PS GREGORY, DA TI DIFFUSED MATCHED-FILTER STORAGE IN PHOTOREFRACTIVE OPTICAL-MATERIALS SO OPTICAL ENGINEERING LA English DT Article DE PHOTOREFRACTIVE NONLINEAR OPTICS; OPTICAL STORAGE; MATCHED FILTERING AB Optical storage in photorefractive crystals such as LiNbO3 is subject to some of the same problems associated with photographic emulsions. Dynamic range limitations are common to both. In a typical optical Fourier transform arrangement, the lower spatial frequencies contain the highest intensities and the higher spatial frequencies are much weaker and are subject to being poorly recorded in multiplexed exposures. This investigation explores and models a simple method for distributing the spectra more evenly throughout the storage media by utilizing a phase diffusing screen. C1 UNIV ALABAMA,HUNTSVILLE,AL 35899. RP MCMILLEN, DK (reprint author), USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD AUG PY 1995 VL 34 IS 8 BP 2232 EP 2239 DI 10.1117/12.210716 PG 8 WC Optics SC Optics GA RN199 UT WOS:A1995RN19900007 ER PT J AU MCMILLEN, DK HUDSON, TD YU, FTS ZHANG, JZ YIN, SZ WU, ZK AF MCMILLEN, DK HUDSON, TD YU, FTS ZHANG, JZ YIN, SZ WU, ZK TI ANOMALIES OF PHOTOVOLTAIC CURRENT IN A CE-FE DOPED LINBO3 CRYSTAL AT 55-DEGREES-C AND 75-DEGREES-C TEMPERATURES SO OPTICAL ENGINEERING LA English DT Article DE PHOTOREFRACTIVE NONLINEAR OPTICS; LITHIUM NIOBATE; PHOTOVOLTAIC CURRENT ID STATE AB The anomalies of photovoltaic current in Ce:Fe doped LiNbO3 crystal at 55 and 75 degrees C temperatures have been investigated, Experiments show that there is about a twofold increase in the photovoltaic current at these temperatures, which is consistent with the anomalies observed in a two-wave mixing experiment reported previously. C1 PENN STATE UNIV,DEPT ELECT ENGN,UNIVERSITY PK,PA 16802. RP MCMILLEN, DK (reprint author), USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD AUG PY 1995 VL 34 IS 8 BP 2240 EP 2242 DI 10.1117/12.209476 PG 3 WC Optics SC Optics GA RN199 UT WOS:A1995RN19900008 ER PT J AU ZHAO, F WU, ZK YU, FTS MCMILLEN, DK AF ZHAO, F WU, ZK YU, FTS MCMILLEN, DK TI TEMPERATURE-DEPENDENCE OF STEADY-STATE BRAGG-DIFFRACTION IN A CE-FE-LINBO3 PHOTOREFRACTIVE CRYSTAL SO OPTICAL ENGINEERING LA English DT Article DE PHOTOREFRACTIVE NONLINEAR OPTICS; BRAGG DIFFRACTION; PHOTOREFRACTIVE CRYSTALS; TEMPERATURE DEPENDENCE ID SCATTERING; GRATINGS; LINBO3; LIGHT; MEDIA AB Steady-state Bragg diffraction (nondegenerate four-wave mixing) in a Ce:Fe:LiNbO3 photorefractive crystal as a function of the crystal temperature is described. We have shown that an efficient steady-state frequency-varied conjugate wave (FVCW) can be generated at an elevated crystal temperature of about 120 degrees C, at which a tenfold increase in the steady-state FVCW intensity is observed compared with that at room temperature (20 degrees C). We have found that the temperature dependency is primarily due to the reduction of light-induced scattering by thermally activated ions that neutralize the noise grating in the crystal. We have also observed that, at higher temperatures, steady-state phase-conjugate waves at both pump wavelengths can be obtained. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP ZHAO, F (reprint author), PENN STATE UNIV,DEPT ELECT ENGN,UNIVERSITY PK,PA 16802, USA. NR 19 TC 3 Z9 5 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD AUG PY 1995 VL 34 IS 8 BP 2243 EP 2247 DI 10.1117/12.211522 PG 5 WC Optics SC Optics GA RN199 UT WOS:A1995RN19900009 ER PT J AU LEACH, A DRAKELEY, CJ DALESSANDRO, U FEGAN, GW BENNETT, S BALLOU, WR TARGETT, GAT GREENWOOD, BM AF LEACH, A DRAKELEY, CJ DALESSANDRO, U FEGAN, GW BENNETT, S BALLOU, WR TARGETT, GAT GREENWOOD, BM TI A PILOT SAFETY AND IMMUNOGENICITY STUDY OF THE MALARIA VACCINE SPF66 IN GAMBIAN INFANTS SO PARASITE IMMUNOLOGY LA English DT Article DE MALARIA; PLASMODIUM FALCIPARUM; SPF66; VACCINE; SAFETY; IMMUNOGENICITY AB A pilot safety and immunogenicity trial of the malar ia vaccine SPf66 has been undertaken in 150 Gambian infants. No significant systemic side effects were recorded but modest local reactions were seen after the administration of a third 1.0 mg dose. SPf66 produced in Colombia was more immunogenic than SPf66 produced in the USA and a 1.0 mg dose of each vaccine gave higher antibody levels than a 0.5 mg dose. However, antibody levels fell rapidly after administration of the third dose of vaccine and showed little change over the following malaria transmission season. The incidence of clinical malaria was higher among children who received SPf66 than among children who received inactivated polio vaccine, the effect being most marked among children who received 1.0 mg Colombian SPf66. As the trial was not designed to measure the effect of SPf66 on morbidity from malaria, the significance of this finding is uncertain. C1 MRC LABS,BANJUL,GAMBIA. UNIV LONDON LONDON SCH HYG & TROP MED,DEPT MED PARASITOL,LONDON WC1E 7HT,ENGLAND. WALTER REED ARMY INST RES,DCD & I,DEPT IMMUNOL,WASHINGTON,DC. RP LEACH, A (reprint author), UNIV LONDON LONDON SCH HYG & TROP MED,DEPT EPIDEMIOL & POPULAT SCI,KEPPEL ST,LONDON WC1E 7HT,ENGLAND. RI D'Alessandro, Umberto/D-3457-2015 OI D'Alessandro, Umberto/0000-0001-6341-5009 FU Wellcome Trust NR 8 TC 22 Z9 22 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0141-9838 J9 PARASITE IMMUNOL JI Parasite Immunol. PD AUG PY 1995 VL 17 IS 8 BP 441 EP 444 DI 10.1111/j.1365-3024.1995.tb00912.x PG 4 WC Immunology; Parasitology SC Immunology; Parasitology GA RV521 UT WOS:A1995RV52100007 PM 7501425 ER PT J AU MONTEMARANO, H BULAS, DI CHANDRA, R TIFFT, C AF MONTEMARANO, H BULAS, DI CHANDRA, R TIFFT, C TI PRENATAL-DIAGNOSIS OF GLOMERULOCYSTIC KIDNEY-DISEASE IN SHORT-RIB POLYDACTYLY SYNDROME TYPE-II, MAJEWSKI TYPE SO PEDIATRIC RADIOLOGY LA English DT Article AB An 18-year-old gravida 1 para 0 female was presented at 35 weeks' gestation with severe oligohydramnios. Sonography revealed a fetus with hydrops, bilaterally enlarged echogenic kidneys, and short extremities. The infant died at birth and autopsy was compatible with short-rib polydactyly syndrome type II, Majewski type. Renal histology was consistent with glomerulocystic disease. C1 CHILDRENS NATL MED CTR,DEPT DIAGNOST IMAGING & RADIOL,WASHINGTON,DC 20010. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. GEORGE WASHINGTON UNIV,SCH MED,WASHINGTON,DC 20010. CHILDRENS NATL MED CTR,DEPT PATHOL,WASHINGTON,DC 20010. CHILDRENS NATL MED CTR,DEPT MED GENET,WASHINGTON,DC 20010. NR 6 TC 6 Z9 7 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0301-0449 J9 PEDIATR RADIOL JI Pediatr. Radiol. PD AUG PY 1995 VL 25 IS 6 BP 469 EP 471 DI 10.1007/BF02019070 PG 3 WC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging SC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging GA RQ474 UT WOS:A1995RQ47400018 PM 7491205 ER PT J AU JOHNSON, RF KNAPIK, JJ MERULLO, DJ AF JOHNSON, RF KNAPIK, JJ MERULLO, DJ TI SYMPTOMS DURING LOAD-CARRYING - EFFECTS OF MASS AND LOAD DISTRIBUTION DURING A 20-KM ROAD MARCH SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article AB Soldiers must often carry heavy loads which can lead to symptoms of body soreness, aches, pains, and tiredness. This study assessed symptoms when soldiers carried loads in the standard U.S. Army ALICE pack (a single backpack) and in a prototype Double Pack (a two-pack system designed to alleviate symptoms by evenly distributing the load between a backpack and a frontpack). Each of 15 male soldiers completed a 20-km (12.4 mi) road march while carrying either 34, 48, or 61 kg (75, 105, or 135 lb) and while wearing either the ALICE pack or the Double Peck. Symptoms were assessed with the Environmental Symptoms Questionnaire. Premarch symptoms included feeling alert, good, and wide awake. Postmarch symptoms included tiredness, muscle tightness, and soreness of the legs, feet, back, and shoulders. Analyses of eight symptom factors showed that (a) as load increased, fatigue and muscle discomfort intensified, and alertness and feelings of well-being diminished and (b) dis tress and heat-illness indices were most intense at 61 kg with the Double Pack. C1 GEOCENTERS INC,NEWTON,MA. RP JOHNSON, RF (reprint author), USA,ENVIRONM MED RES INST,DIV MIL PERFORMANCE & NEUROSCI,NATICK,MA 01760, USA. NR 9 TC 35 Z9 35 U1 0 U2 4 PU PERCEPTUAL MOTOR SKILLS PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807 SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD AUG PY 1995 VL 81 IS 1 BP 331 EP 338 PG 8 WC Psychology, Experimental SC Psychology GA RV641 UT WOS:A1995RV64100063 PM 8532476 ER PT J AU GENOVESE, RF DOCTOR, BP AF GENOVESE, RF DOCTOR, BP TI BEHAVIORAL AND PHARMACOLOGICAL ASSESSMENT OF BUTYRYLCHOLINESTERASE IN RATS SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE BUTYRYLCHOLINESTERASE; MEPQ; MOTOR ACTIVITY; OPERANT BEHAVIOR; ORGANOPHOSPHORUS; PASSIVE AVOIDANCE ID SCHEDULE-CONTROLLED BEHAVIOR; ACETYLCHOLINESTERASE PROPHYLAXIS; COGNITION ENHANCERS; PRETREATMENT DRUGS; SOMAN TOXICITY; RHESUS-MONKEYS; NERVE AGENTS; PROTECTION; PHYSOSTIGMINE; CHOLINESTERASES AB Advances in the treatment of organophosphorus (OP) toxicity have focussed on the use of exogenous cholinesterases to act as scavengers for the OP agent. To further investigate the feasibility of the scavenger approach, we evaluated the effects of highly purified horse serum butyrylcholinesterase (HS-BChE) on performance in rats. HS-BChE (5000 U, IP) produced substantial increases in blood enzyme activity for up to 72 h after injection HS-BChE (5000 U, IP) had no effect on acquisition or retention of a passive avoidance task. In contrast, atropine sulfate (10 mg/kg) impaired retention when tested 168 h after administration When examined for 10 days following administration, HS-BChE (7500 U, IP) had no effect on either total daily motor activity or circadian pattern of activity. HS-BChE (5000 U, IM) also had no acute or prolonged effects on the rate of lever pressing maintained by a VI56 s schedule of food reinforcement HS-BChE (7500 U, IM) was observed to confer significant, but partial, protection against response rate decreases produced by the OP, MEPQ, under the VI56 s schedule of reinforcement. These results suggest that, in rats, HS-BChE, at doses that attenuate OP toxicity, may be devoid of cognitive or motor effects. C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. RP GENOVESE, RF (reprint author), WALTER REED ARMY INST RES,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 28 TC 24 Z9 24 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD AUG PY 1995 VL 51 IS 4 BP 647 EP 654 DI 10.1016/0091-3057(95)91937-L PG 8 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA RF377 UT WOS:A1995RF37700013 PM 7675838 ER PT J AU JOHNSONWINEGAR, A AF JOHNSONWINEGAR, A TI THE ROLE OF DECLARATIONS IN UNSCOMS PROGRAM IN IRAQ SO POLITICS AND THE LIFE SCIENCES LA English DT Article RP JOHNSONWINEGAR, A (reprint author), USA,MED RES & MAT COMMAND,MED BIOL DEF RES PROGRAM,FT DETRICK,MD 21702, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU BEECH TREE PUBLISHING PI GUILDFORD PA 10 WATFORD CLOSE, GUILDFORD, SURREY, ENGLAND GU1 2EP SN 0730-9384 J9 POLIT LIFE SCI JI Polit. Life Sci. PD AUG PY 1995 VL 14 IS 2 BP 236 EP 238 PG 3 WC Biology; History & Philosophy Of Science; Social Issues SC Life Sciences & Biomedicine - Other Topics; History & Philosophy of Science; Social Issues GA TB224 UT WOS:A1995TB22400020 ER PT J AU FRANZ, DR AF FRANZ, DR TI INVENTORY CONTROL OF DUAL-USE EQUIPMENT SO POLITICS AND THE LIFE SCIENCES LA English DT Article RP FRANZ, DR (reprint author), USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702, USA. NR 5 TC 4 Z9 4 U1 0 U2 0 PU BEECH TREE PUBLISHING PI GUILDFORD PA 10 WATFORD CLOSE, GUILDFORD, SURREY, ENGLAND GU1 2EP SN 0730-9384 J9 POLIT LIFE SCI JI Polit. Life Sci. PD AUG PY 1995 VL 14 IS 2 BP 244 EP 247 PG 4 WC Biology; History & Philosophy Of Science; Social Issues SC Life Sciences & Biomedicine - Other Topics; History & Philosophy of Science; Social Issues GA TB224 UT WOS:A1995TB22400023 ER PT J AU HOFER, RC LOPER, ML AF HOFER, RC LOPER, ML TI DIS TODAY SO PROCEEDINGS OF THE IEEE LA English DT Article C1 GEORGIA INST TECHNOL,GEORGIA TECH RES INST,ATLANTA,GA 30332. RP HOFER, RC (reprint author), USA,SIMULAT TRAINING & INSTRUMENTAT COMMAND,ORLANDO,FL 32826, USA. NR 24 TC 20 Z9 21 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9219 J9 P IEEE JI Proc. IEEE PD AUG PY 1995 VL 83 IS 8 BP 1124 EP 1137 DI 10.1109/5.400453 PG 14 WC Engineering, Electrical & Electronic SC Engineering GA RM615 UT WOS:A1995RM61500003 ER PT J AU SHIFLETT, JE LUNCEFORD, WH WILLIS, RP AF SHIFLETT, JE LUNCEFORD, WH WILLIS, RP TI APPLICATION OF DISTRIBUTED INTERACTIVE SIMULATION TECHNOLOGY WITHIN THE DEPARTMENT-OF-DEFENSE SO PROCEEDINGS OF THE IEEE LA English DT Article AB This paper focuses on distributed interactive simulation (DIS) as an emerging technology which offers new opportunities for the Department of Defense in the design of simulation systems, the approach to training, and the improvement of the materiel acquisition process. Discussion of these topics is followed by an overview of selected Department of Defense programs that employ DIS. The paper concludes with a brief discussion of technology challenges that must be overcome for this technology to reach its full potential. C1 USN,CTR WARFARE,DIV TRAINING SYST,TRAINING TECHNOL APPLICAT BRANCH,ORLANDO,FL 32826. RP SHIFLETT, JE (reprint author), USA,TRAINING & INSTRUMENTAT COMMAND,ORLANDO,FL 32826, USA. NR 15 TC 2 Z9 2 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9219 J9 P IEEE JI Proc. IEEE PD AUG PY 1995 VL 83 IS 8 BP 1168 EP 1178 DI 10.1109/5.400456 PG 11 WC Engineering, Electrical & Electronic SC Engineering GA RM615 UT WOS:A1995RM61500006 ER PT J AU FLAMAND, M CHEVALIER, M HENCHAL, E GIRARD, M DEUBEL, V AF FLAMAND, M CHEVALIER, M HENCHAL, E GIRARD, M DEUBEL, V TI PURIFICATION AND RENATURATION OF JAPANESE ENCEPHALITIS-VIRUS NONSTRUCTURAL GLYCOPROTEIN NS1 OVERPRODUCED BY INSECT CELLS SO PROTEIN EXPRESSION AND PURIFICATION LA English DT Article ID ESCHERICHIA-COLI; EXPRESSION VECTORS; INCLUSION-BODIES; PROTEIN NS1; FLAVIVIRUS; BACULOVIRUS; REPLICATION; DISULFIDES; CHAPERONES; FORM AB The nonstructural protein NS1 of Japanese encephalitis virus is a major immunogen produced during flavivirus infection. However, the function of this protein has not been identified. To analyze its biochemical properties and evaluate its potential activity in the virus life cycle, the protein was produced in Spodoptera frugiperda insect cells (Sf9), using a recombinant baculovirus, and purified. As described previously by M. Flamand, V. Deubel, and M. Girard (1992, Virology 191, 826-836), a small fraction of the synthesized recombinant protein could mature into a dimer, whereas the major part was retained in intracellular aggregates. This insolubility was used to recover the protein in a purified form using a two-step procedure. Isolated inclusion bodies, in which NS1 constituted over 60% of the protein, were solubilized in 8 M urea. NS1 was further purified by reverse-phase HPLC and recovered at over 90% purity with an overall yield of over 60%. Conditions promoting reoxidation-renaturation of the purified protein were then investigated at a concentration of 100 mu g/ml at pH 8. The presence of 8 M urea during reoxidation of NS1 with oxidized glutathione was essential prior to renaturation by dialysis to avoid reaggregation, the main side pathway of refolding in. vitro. Three major species, all monomeric, were resolved by nonreducing SDS-PAGE. The form showing the lowest apparent molecular weight comigrated with native unreduced NS1 and was recognized by a monoclonal antibody directed against a conformational epitope strictly dependent on the native structure of the protein. Thus, this form, representing over 30% of the renatured products, may have reached the native conformation of the protein. This simple renaturation-reoxidation procedure may be applicable to other disulfide bond-containing proteins to be recovered in the native state from inclusion bodies. (C) 1995 Academic Press, Inc. C1 PASTEUR MERIEUX SERUMS & VACCINS,F-69280 MARCY LETOILE,FRANCE. USA,MED RES INST INFECT DIS,DIV VIROL,DEPT MOLEC VIROL,FREDERICK,MD 21702. INST PASTEUR,UNITE VIROL MOLEC,F-75015 PARIS,FRANCE. RP FLAMAND, M (reprint author), INST PASTEUR,UNITE ARBOVIRUS & VIRUS FIEVRES HEMORRAG,25 RUE DR ROUX,F-75015 PARIS,FRANCE. NR 36 TC 5 Z9 5 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 1046-5928 J9 PROTEIN EXPRES PURIF JI Protein Expr. Purif. PD AUG PY 1995 VL 6 IS 4 BP 519 EP 527 DI 10.1006/prep.1995.1069 PG 9 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA RM609 UT WOS:A1995RM60900019 PM 8527939 ER PT J AU CALDWELL, J AF CALDWELL, J TI SUSTAINING THE ALERTNESS OF FEMALES WITH DEXEDRINE DURING SLEEP-DEPRIVATION SO PSYCHOPHYSIOLOGY LA English DT Meeting Abstract C1 USA,AEROMED RES LAB,WASHINGTON,DC 20310. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC PSYCHOPHYSIOL RES PI WASHINGTON PA 1010 VERMONT AVE NW SUITE 1100, WASHINGTON, DC 20005 SN 0048-5772 J9 PSYCHOPHYSIOLOGY JI Psychophysiology PD AUG PY 1995 VL 32 SU 1 BP S23 EP S23 PG 1 WC Psychology, Biological; Neurosciences; Physiology; Psychology; Psychology, Experimental SC Psychology; Neurosciences & Neurology; Physiology GA RT160 UT WOS:A1995RT16000095 ER PT J AU BRIGGS, MJ SYNOLAKIS, CE HARKINS, GS GREEN, DR AF BRIGGS, MJ SYNOLAKIS, CE HARKINS, GS GREEN, DR TI LABORATORY EXPERIMENTS OF TSUNAMI RUNUP ON A CIRCULAR ISLAND SO PURE AND APPLIED GEOPHYSICS LA English DT Article DE TSUNAMIS; TSUNAMI RUNUP; LABORATORY EXPERIMENTS; PHYSICAL MODELS; 3-DIMENSIONAL MODELS; TSUNAMI SIMULATION; SOLITARY WAVES; WAVE-MAKERS; TSUNAMI EVOLUTION; INSTRUMENTATION ID WAVES AB Laboratory experiments of a 7.2-m-diameter conical island were conducted to study three-dimensional tsunami runup. The 62.5-cm tall island had 1 on 4 side slopes and was positioned in the center of a 30-m-wide by 25-m-long flat-bottom basin. Solitary waves with height-to-depth ratios ranging from 0.05 to 0.20 and ''source'' lengths ranging from 0.30 to 7.14 island diameters were tested in water depths of 32 and 42 cm. Twenty-seven capacitance wave gages were used to measure surface wave elevations at incident and four radial transects on the island slope. Maximum vertical runup measurements were made at 20 locations around the perimeter of the island using rod and transit. A new runup gage was located on the back or lee side of the island to record runup time series. C1 UNIV SO CALIF,DEPT CIVIL & AEROSP ENGN,LOS ANGELES,CA. RP BRIGGS, MJ (reprint author), USA,COASTAL ENGN RES CTR,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. RI Synolakis, Costas/B-3197-2008 OI Synolakis, Costas/0000-0003-0140-5379 NR 12 TC 109 Z9 111 U1 1 U2 7 PU BIRKHAUSER VERLAG AG PI BASEL PA PO BOX 133 KLOSTERBERG 23, CH-4010 BASEL, SWITZERLAND SN 0033-4553 J9 PURE APPL GEOPHYS JI Pure Appl. Geophys. PD AUG PY 1995 VL 144 IS 3-4 BP 569 EP 593 DI 10.1007/BF00874384 PG 25 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA RX790 UT WOS:A1995RX79000012 ER PT J AU CHANDNANI, V AF CHANDNANI, V TI MR-IMAGING VERSUS STRESS RADIOGRAPHY IN THE EVALUATION OF CHRONIC ANKLE INSTABILITY - RESPONSE SO RADIOLOGY LA English DT Letter RP CHANDNANI, V (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD AUG PY 1995 VL 196 IS 2 BP 580 EP 581 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA RK619 UT WOS:A1995RK61900052 ER PT J AU HOWARD, SL CHANG, LM KOOKER, DE AF HOWARD, SL CHANG, LM KOOKER, DE TI THERMOCOUPLE SENSOR FOR RAPID TEMPERATURE-MEASUREMENTS DURING IGNITION AND EARLY PHASE COMBUSTION OF PACKED PROPELLANT BEDS SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID RHODIUM AB Flame-spreading processes during the ignition of ballistic events have long been studied by pressure measurements and visual records from high-speed film. While optical temperature measurements have been utilized, they are not useful much below 1500 K. A fine-wire platinum versus 10% Rh/platinum thermocouple probe was designed to measure gas temperature in a packed propellant bed over the range from the initial bed temperature (295 K) to more than 2000 K. Probe mounts were designed to provide sufficient physical support and protection for the thermocouples and yet minimally perturb the flow environment. Three diameters of fine-wire thermocouples were tested for survivability and time response in the simulated pressure-wave environment of ignition of a propellant bed. The largest diameter thermocouple (3 mil or 76 mu m) exhibited a response time too great (3 ms). The smallest diameter (1 mil or 25 mu m) exhibited the shortest response time (0.4 ms) and would be the thermocouple of choice for this experiment; however, it was not used in the current experiments due to difficulties in probe fabrication and consideration of wire strength. For this application, a 2 mil (51 mu m) diameter thermocouple was chosen. The lag time for this thermocouple was estimated at approximately 1.5 ms. Corrections to the temperature for catalytic activity (<1 K) and radiative cooling (60 K in the plateau region) were estimated. Examples of temperature histories during ignition of M30A1 and M43 propellants are also included. RP HOWARD, SL (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 30 TC 5 Z9 5 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD AUG PY 1995 VL 66 IS 8 BP 4259 EP 4266 DI 10.1063/1.1145379 PG 8 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA RP408 UT WOS:A1995RP40800040 ER PT J AU SCHMIDT, JJ WEINSTEIN, SA AF SCHMIDT, JJ WEINSTEIN, SA TI STRUCTURE-FUNCTION STUDIES OF WAGLERIN-I, A LETHAL PEPTIDE FROM THE VENOM OF WAGLER PIT VIPER, TRIMERESURUS-WAGLERI SO TOXICON LA English DT Article AB Waglerins are 22-24 residue lethal peptides, found in the venom of Trimeresurus (Tropidolaemus) wagleri. The effects upon lethality and immunoreactivity resulting from structural modifications of these peptides were studied. A synthetic analogue with alanine residues in place of the two half-cystines of native peptide was nontoxic, suggesting that the single intramolecular disulfide bond in waglerins is critical for bioactivity. Substituting glutamic acid for aspartic acid at residue 5 slightly diminished lethality. Analogues containing asparagine instead of aspartic acid at residue 5 and/or a carboxamide- instead of a carboxy-terminus were lethal, demonstrating that neither a negative charge on residue 5 nor on the carboxy-terminus was required for bioactivity. A proteolytic fragment of waglerin I containing residues 6-22 was isolated and proved nontoxic. Therefore, one or more of the first five residues were necessary for bioactivity. Antiserum against waglerin I bound strongly to waglerins I, II, and SL-I, and to various analogues, proteolytic fragments, and chemically modified waglerin I. These findings suggest that the antibodies might be directed mainly against short, linear epitopes, implying an extended conformation for waglerin I. RP SCHMIDT, JJ (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702, USA. NR 11 TC 10 Z9 11 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD AUG PY 1995 VL 33 IS 8 BP 1043 EP 1049 DI 10.1016/0041-0101(95)00043-L PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA RP659 UT WOS:A1995RP65900003 PM 8533138 ER PT J AU BRYAN, JP CRAIG, PG REYES, L HAKRE, S JARAMILLO, R HARLAN, H MACARTHY, P LEGTERS, LJ AF BRYAN, JP CRAIG, PG REYES, L HAKRE, S JARAMILLO, R HARLAN, H MACARTHY, P LEGTERS, LJ TI RANDOMIZED COMPARISON OF 5 AND 10 MU-G DOSES OF 2 RECOMBINANT HEPATITIS-B VACCINES SO VACCINE LA English DT Article DE HEPATITIS B; HEPATITIS B VACCINE ID PLASMA-DERIVED VACCINE; IMMUNOGENICITY; REACTOGENICITY; ADULTS AB The high cost of hepatitis B vaccines remains an obstacle to their use. Since the recommended adult dose of Recombivax HB (MSD) is 10 mu g and that of Engerix B (SKB) is 20 mu g, we sought to determine if 10 mu g doses of each vaccine are equally immunogenic. Further, since 5 mu g doses of Recombivax are routinely used in those less than or equal to 29 years of age in the US military, we sought to compare this dose with 5 mu g doses of Engerix B. Lower doses of Engerix would result in vaccine cost savings. Methods. members of the Belize Defence Force who were greater than or equal to 18 years of age (median 24) without detectable anti-HBc were randomly assigned to receive Recombivax, 5 or 10 mu g, or Engerix, 5 or 10 mu g IM at 0, 1, and 6 months. Randomization was weighted toward Engerix. Results. after 3 doses, geometric mean concentrations (GMC) of anti-HBs were highest among those receiving Recombivax 10 mu g (n = 22) or 5 mu g (n = 46) with GMC anti-HBs of 744 and 570 mlU ml(-1) respectively. Similar proportions in the two groups developed greater than or equal to 10 mlU ml(-1) anti-HBs (100 and 98%). Among the 91 people who received Engerix 10 mu g, the GMC anti-HBs was 325 mIU ml(-1) and 91% developed greater than or equal to 10 mlU ml(-1). The 87 people who received Engerix 5 mu g had the lowest GMC, 177 mIU ml(-1) (p < 0.05 compared with either Recombivax group). Only 86% attained greater than or equal to 10 mlU ml(-1) anti-HBs (p > 0.05 compared with other regimens). The proportion attaining greater than or equal to 100 mlU ml(-1) was lower in the 5 mu g Engerix group (63%) compared with 80% in the 5 mu g or 95% in the 10 mu g Recombivax groups (p < 0.05). Conclusions: Engerix administered in 5 mu g doses is less immunogenic than 5 or 10 mu g doses of Recombivax. In healthy populations < 30 years of age, regimens of half the recommended adult dose (5 mu g of Recombivax or 10 mu g of Engerix) are highly immunogenic and may result in significant vaccine cost savings. C1 BELIZE DEF FORCE,BELIZE CITY,BELIZE. EPIDEMIOL RES CTR,BELIZE CITY,BELIZE. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP BRYAN, JP (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR,USNR DIV TROP PUBL HLTH,BETHESDA,MD 20814, USA. NR 28 TC 13 Z9 15 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP SN 0264-410X J9 VACCINE JI Vaccine PD AUG PY 1995 VL 13 IS 11 BP 978 EP 982 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA RV516 UT WOS:A1995RV51600004 PM 8525691 ER PT J AU WHITE, WI CASSATT, DR MADSEN, J BURKE, SJ WOODS, RM WASSEF, NM ALVING, CR KOENIG, S AF WHITE, WI CASSATT, DR MADSEN, J BURKE, SJ WOODS, RM WASSEF, NM ALVING, CR KOENIG, S TI ANTIBODY AND CYTOTOXIC T-LYMPHOCYTE RESPONSES TO A SINGLE LIPOSOME-ASSOCIATED PEPTIDE ANTIGEN SO VACCINE LA English DT Article DE ANTIBODY; CYTOTOXIC T LYMPHOCYTE; ADJUVANT; LIPOSOMES; PEPTIDE ANTIGEN ID IMMUNOLOGICAL ADJUVANTS; PROTEIN ANTIGENS; LIPID-A; ENCAPSULATED ANTIGENS; SYNTHETIC PEPTIDES; HUMORAL RESPONSE; HIV-1 GP120; VIRUS; VACCINES; IMMUNOGENICITY AB The development of peptide-based vaccines that elicit antibody (Ab) and cellular immune responses has been hampered by the lack of highly immunogenic formulations. In this study, we compared the induction of Ab and cytotoxic T-lymphocyte (CTL) responses to a peptide derived from the V3 loop of HIV-1 gp120 (P18 and its cysteine-glycine derivative (CG-P18)) when incorporated into liposomes with lipid A (LA) or mixed with aluminum hydroxide. P18-specific CTL were only observed with liposomes with LA. P18-specific Ab responses were found with liposomes containing CG-P18 but not P18. Increased surface expression of the former, resulted in enhancement of the Ab response without loss of CTL induction. Thus, the manner in which a peptide is localized can influence the outcome of the response induced by highly immunogenic liposome formulations. C1 MEDIMMUNE INC,DEPT PEPTIDE CHEM,GAITHERSBURG,MD 20878. WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. RP WHITE, WI (reprint author), MEDIMMUNE INC,DEPT IMMUNOL,35 W WATKINS MILL RD,GAITHERSBURG,MD 20878, USA. FU NIAID NIH HHS [AI-2817] NR 57 TC 44 Z9 45 U1 0 U2 2 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP SN 0264-410X J9 VACCINE JI Vaccine PD AUG PY 1995 VL 13 IS 12 BP 1111 EP 1122 DI 10.1016/0264-410X(94)00058-U PG 12 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA RV517 UT WOS:A1995RV51700010 PM 7491819 ER PT J AU GLENN, GM KROBER, MS KELLY, P MCCARTY, J WEIR, M AF GLENN, GM KROBER, MS KELLY, P MCCARTY, J WEIR, M TI PYRIDOXINE AS THERAPY IN THEOPHYLLINE-INDUCED SEIZURES SO VETERINARY AND HUMAN TOXICOLOGY LA English DT Article ID SENSORY NEUROPATHY; RAT-BRAIN; AMINOPHYLLINE; TOXICITY; ADENOSINE; CAFFEINE; OVERDOSE; GABA AB Theophylline-induced seizures have significant morbidity and mortality and are difficult to treat. Theophylline therapy for asthma has been observed to depress plasma pyriodoxal 5'-phosphate (PLP) levels which may decrease gamma-aminobutyric acid (GABA) synthesis and thereby contribute to seizures. We hypothesized that treatment with pyridoxine might prove beneficial in theophylline-induced seizures. One hundred thirty-nine mice were injected with 250 mg theophylline/kg ip and 89 mice were injected with 250-750 mg pyridoxine/kg ip as treatment. Decreased rates of seizure (42 vs 70%, p<0.002) and death 29 vs 56%, p<0.002) were observed. Six New Zealand White rabbits were given 115 mg theophylline/kg iv over 50 min followed by treatment with an iv bolus of 115 mg pyridoxine/kg, with subsequent continuous drip infusion of 230 mg/kg over 50 min. Serum theophylline levels and plasma PLP levels showed significant negative correlation prior to pyridoxine infusion with a mean peak theophylline level of 182 mu g/ml and a mean low PLP level of 64 nM/L. Electroenceph-alogram (EEG) tracings were obtained before infusions, during theophylline infusion and during pyridoxine infusion. All 6 rabbits developed abnormal EEGs during theophylline infusion and all 6 rabbit EEG patterns returned to baseline during treatment with pyridoxine. These findings suggest that pyridoxine may partially reverse theophylline-induced central nervous system toxicity. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. MADIGAN ARMY MED CTR,DEPT PEDIAT,TACOMA,WA 98431. HOLT CROCK CLIN,FT SMITH,AR 72901. TEXAS A&M UNIV,SCOTT & WHITE MEM HOSP & CLIN,HLTH SCI CTR,COLL MED,DEPT PEDIAT,TEMPLE,TX 76508. NR 31 TC 26 Z9 27 U1 3 U2 5 PU COMPARATIVE TOXICOLOGY LAB KANSAS STATE UNIV PI MANHATTAN PA MANHATTAN, KS 66506 SN 0145-6296 J9 VET HUM TOXICOL JI Vet. Human Toxicol. PD AUG PY 1995 VL 37 IS 4 BP 342 EP 345 PG 4 WC Toxicology; Veterinary Sciences SC Toxicology; Veterinary Sciences GA RL203 UT WOS:A1995RL20300014 PM 8540225 ER PT J AU PETERS, MR ABT, SR WATSON, CC FISCHENICH, JC NESTLER, JM AF PETERS, MR ABT, SR WATSON, CC FISCHENICH, JC NESTLER, JM TI ASSESSMENT OF RESTORED RIVERINE HABITAT USING RCHARC SO WATER RESOURCES BULLETIN LA English DT Article DE AQUATIC ECOSYSTEMS; HYDRAULICS; SIMULATION; HABITAT AB The Riverine Community Habitat Assessment and Restoration Concept (RCHARC) was developed to integrate habitat enhancement into the stream restoration process. RCHARC assumes that aquatic habitat quality is closely related to hydraulic diversity based upon a ''comparison standard'' reach approach to stream restoration. A Beta test was performed by applying the RCHARC process to Rapid Creek in Rapid City, South Dakota. Standard and restored stream reaches were selected and data were collected. A comparison of field data and velocity-depth distributions indicated that the restored stream closely replicated the standard reach. The RCHARC methodology has the potential to assess habitat quality for planned comparison reaches and indicate the level of success resulting from restoration. C1 COLORADO STATE UNIV,DEPT CIVIL ENGN,FT COLLINS,CO 80523. USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. RP PETERS, MR (reprint author), SIMONS & ASSOCIATES INC,FT COLLINS,CO 80525, USA. NR 8 TC 4 Z9 4 U1 0 U2 2 PU AMER WATER RESOURCES ASSOC PI HERNDON PA 950 HERNDON PARKWAY SUITE 300, HERNDON, VA 22070-5528 SN 0043-1370 J9 WATER RESOUR BULL JI Water Resour. Bull. PD AUG PY 1995 VL 31 IS 4 BP 745 EP 752 PG 8 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA RP305 UT WOS:A1995RP30500017 ER PT J AU FERRICK, MG MULHERIN, ND CALKINS, DJ AF FERRICK, MG MULHERIN, ND CALKINS, DJ TI ANALYSIS OF THE WINTER LOW-FLOW BALANCE OF THE SEMIARID WHITE RIVER, NEBRASKA AND SOUTH-DAKOTA SO WATER RESOURCES RESEARCH LA English DT Article ID ICE AB Low-flow studies are needed to quantify the effects of water consumption on streamflow, water quality, groundwater resources, and contaminant transport. The low-flow water balance of a river in a cold region is simplified in winter because evapotranspiration is negligible, irrigation water withdrawals and diversions are halted, and precipitation occurs largely as snow, minimizing the spatial and temporal variability of runoff. We investigated the monthly low-flow water balance of White River reaches over seven consecutive winters. Water going into or out of storage as ice or melt, obtained with an air temperature index model, can be a dominant component of the water balance. The point estimate method is used to account for parameter uncertainty and variability, providing the mean, variance, and limits of dependent variables such as water storage as ice and inflow from a subbasin. Negative surface water yield from several-thousand-square-kilometer subbasins occurred regularly through the period, indicating a significant flow from the river to the alluvial aquifers. The winter water balance results suggest either a perched river or a coupled surface water-groundwater hydrologic system in particular subbasins, consistent with the field investigations of Rothrock (1942). The winter flow exchange between the surface and subsurface can be used to estimate the annual exchange for both hydrologic conditions. RP FERRICK, MG (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 22 TC 0 Z9 0 U1 0 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD AUG PY 1995 VL 31 IS 8 BP 1999 EP 2009 DI 10.1029/95WR01269 PG 11 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA RM644 UT WOS:A1995RM64400015 ER PT J AU ARANDA, FJ GARIMELLA, R MCCARTHY, NF RAO, DN CHEN, Z AKKARA, JA KAPLAN, DL ROACH, JF AF ARANDA, FJ GARIMELLA, R MCCARTHY, NF RAO, DN CHEN, Z AKKARA, JA KAPLAN, DL ROACH, JF TI ALL-OPTICAL LIGHT-MODULATION IN BACTERIORHODOPSIN FILMS SO APPLIED PHYSICS LETTERS LA English DT Article AB We report a convenient method to obtain all-optical light modulation in bacteriorhodopsin films using a degenerate four-wave mixing geometry. Chemically stabilized films of bacteriorhodopsin in a polymer matrix for which the lifetime of the excited M state is tens of seconds were used to demonstrate all-optical light intensity modulation. The films are observed to be stable over a period of 4 years. Due to the sensitivity of the films, small intensities of order microwatt/ cm(2) are required in the modulation experiments. Furthermore the fast photochemical transition from M to B permit reasonably fast modulation speeds independent of the slow thermal M and B relaxation time. The experimental system also acts as an all-optical switch where a low power blue pulse turns on a signal red beam. (C) 1995 American Institute of Physics. C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RP ARANDA, FJ (reprint author), UNIV MASSACHUSETTS,DEPT PHYS,BOSTON,MA 02125, USA. NR 25 TC 26 Z9 29 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 31 PY 1995 VL 67 IS 5 BP 599 EP 601 DI 10.1063/1.115401 PG 3 WC Physics, Applied SC Physics GA RL976 UT WOS:A1995RL97600008 ER PT J AU KEEBLE, DJ LI, Z POINDEXTER, EH AF KEEBLE, DJ LI, Z POINDEXTER, EH TI ELECTRON-PARAMAGNETIC-RESONANCE OF MN4+ IN PBTIO3 SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Article ID SUPERPOSITION-MODEL; BATIO3; CRYSTALS AB The electron paramagnetic resonance spectrum of Mn4+ in single-crystal lead titanate has been studied at 9.8 and 33.8 GHz. An axial sextet with g(perpendicular to)(eff) = 3.7742(1) to g(parallel to)(eff) approximate to 2.00 was measured at 9.8 GHz and with g(perpendicular to)(eff) = 2.7048(15) at 33.8 GHz; a second sextet was observed at high held at 9.8 GHz. The spectrum was fitted using spin Hamiltonian parameters S = 3/2, I =5/2, g(parallel to) = 1.99, g(perpendicular to) = 1.987, A(parallel to) = 79.46 x 10(-4) cm(-1), A(perpendicular to) = 71.05 x 10(-4) cm(-1) and \D\ = 0.3166 cm(-1). The electronic spin value and the magnitude of the hyperfine constant, \A\ = 73.9 cm(-1), confirm the Mn4+ assignment. A superposition model analysis using available (b) over bar(2)(R) functions for 3d(3) configuration ions in oxide hosts was unable to reproduce the observed axial crystal field magnitude, \D\. C1 ARGONNE NATL LAB,DIV MAT SCI,ARGONNE,IL 60439. USA,RES LAB,DIV PHYS,FT MONMOUTH,NJ 07703. UNIV DUNDEE,DEPT APPL PHYS & ELECTR & MECH ENGN,DUNDEE DD1 4HN,SCOTLAND. RP KEEBLE, DJ (reprint author), MICHIGAN TECHNOL UNIV,DEPT PHYS,HOUGHTON,MI 49931, USA. RI Keeble, David /C-6633-2012 OI Keeble, David /0000-0002-5378-799X NR 22 TC 23 Z9 24 U1 2 U2 8 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0953-8984 J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD JUL 31 PY 1995 VL 7 IS 31 BP 6327 EP 6333 DI 10.1088/0953-8984/7/31/015 PG 7 WC Physics, Condensed Matter SC Physics GA RM972 UT WOS:A1995RM97200015 ER PT J AU JENSEN, JO KRISHNAN, PN BURKE, LA AF JENSEN, JO KRISHNAN, PN BURKE, LA TI THEORETICAL-STUDY OF WATER CLUSTERS - HEPTAMERS SO CHEMICAL PHYSICS LETTERS LA English DT Article ID ABINITIO; TRIMER; SPECTRA; MODEL AB Seven structures of the (H2O)(7) are examined. Calculations were carried out with a Hartree-Fock wavefunction using the 6-311G*, and 6-311G** basis sets. SCF force constants were calculated with both basis sets and the information used to generate thermodynamic data. The enthalpies, entropies, and flee energies of the seven structures are presented and compared. Infrared and Raman spectra are also calculated and examined. C1 COPPIN STATE COLL,DEPT NAT SCI,BALTIMORE,MD 21216. RUTGERS STATE UNIV,DEPT CHEM,CAMDEN,NJ 08102. RP JENSEN, JO (reprint author), USA,CTR DEV & ENGN,EDGEWOOD RES,ABERDEEN PROVING GROUND,MD 21010, USA. NR 23 TC 32 Z9 34 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD JUL 21 PY 1995 VL 241 IS 3 BP 253 EP 260 DI 10.1016/0009-2614(95)00627-G PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA RL181 UT WOS:A1995RL18100017 ER PT J AU XIE, K FLEMISH, JR ZHAO, JH BUCHWALD, WR CASAS, L AF XIE, K FLEMISH, JR ZHAO, JH BUCHWALD, WR CASAS, L TI LOW DAMAGE AND RESIDUE-FREE DRY-ETCHING OF 6H-SIC USING ELECTRON-CYCLOTRON-RESONANCE PLASMA SO APPLIED PHYSICS LETTERS LA English DT Article ID THIN-FILM DEPOSITION; SILICON-CARBIDE; BETA; INTERFACE; MIXTURES AB Dry etching-induced surface damage and contamination on SiC have been investigated for electron cyclotron resonance (ECR) plasma etching and conventional reactive ion etching (RIE) using a CF4/O-2 gas mixture. Auger electron spectroscopy shows that there is no residue on the ECR etched surfaces and sidewalls of the etched structures. In contrast, the conventional RIE process leaves residues containing large amounts of Al, F, and O impurities on the surfaces and the etched sidewalls. Pd Schottky diodes on the ECR etched surface show a near-ideal diode characteristics with ideality factor of 1.06, indicating a good surface quality. Pd Schottky diodes on the a conventional RIE etched surface, however, have a substantially reduced barrier height from 1.05 eV for the as-grown sample to 0.64 eV and a high ideality factor of 1.27, indicating a substantially damaged surface. Significant foe-carrier reduction is observed in the RIE etched sample. (C) 1995 American Institute of Physics. C1 RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. RP XIE, K (reprint author), USA,RES LAB,PHYS SCI DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 21 TC 37 Z9 39 U1 2 U2 6 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 17 PY 1995 VL 67 IS 3 BP 368 EP 370 DI 10.1063/1.114631 PG 3 WC Physics, Applied SC Physics GA RK396 UT WOS:A1995RK39600024 ER PT J AU BASHIRHASHEMI, A IYER, S ALSTER, J SLAGG, N AF BASHIRHASHEMI, A IYER, S ALSTER, J SLAGG, N TI CUBANES AND CAGE RELATED MOLECULES SO CHEMISTRY & INDUSTRY LA English DT Article ID CUBYL CATION; SYSTEMATIC SUBSTITUTION; CHEMISTRY; PHENYLCUBANES; NUCLEUS C1 USA,CTR ARMAMENT RES DEV & ENGN,DIV ENERGET & WARHEADS,PICATINNY ARSENAL,NJ 07806. RP BASHIRHASHEMI, A (reprint author), USA,CTR ARMAMENT RES DEV & ENGN,GEOCTR,PICATINNY ARSENAL,NJ 07806, USA. NR 74 TC 18 Z9 18 U1 0 U2 3 PU SOC CHEMICAL INDUSTRY PI LONDON PA 14 BELGRAVE SQUARE, LONDON, ENGLAND SW1X 8PS SN 0009-3068 J9 CHEM IND-LONDON JI Chem. Ind. PD JUL 17 PY 1995 IS 14 BP 551 EP 555 PG 5 WC Chemistry, Applied SC Chemistry GA RK245 UT WOS:A1995RK24500008 ER PT J AU GUPTA, AD SANTIAGO, JM MEYER, C AF GUPTA, AD SANTIAGO, JM MEYER, C TI COMPARISON OF COMPUTATIONAL AND EXPERIMENTAL MODAL ANALYSES OF AN ARMORED VEHICLE HULL WITH MULTIPLE-ACCESS OPENINGS SO COMPUTERS & STRUCTURES LA English DT Article; Proceedings Paper CT 10th ADINA Conference on Nonlinear Finite Element Analysis and ADINA CY JUN 21-23, 1995 CL MIT, CAMBRIDGE, MA HO MIT AB A three-dimensional (3D) finite element model of a bare aluminum vehicle hull with multiple access openings for the driver's hatch, the commander's cupola, engine access opening, exhaust grills, cargo hatch, as well as rear door cutout, representing the basic hull of the armored personnel carrier (APC) M113A2 was generated using PATRAN 3 pre and post-processor program. Frequencies and modeshapes obtained using the ADINA finite element code were compared with available experimental modal analysis data for the counterpart hull. RP GUPTA, AD (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-7949 J9 COMPUT STRUCT JI Comput. Struct. PD JUL 17 PY 1995 VL 56 IS 2-3 BP 411 EP 414 DI 10.1016/0045-7949(95)00033-D PG 4 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA RE799 UT WOS:A1995RE79900020 ER PT J AU WIZEL, B HOUGHTEN, R CHURCH, P TINE, JA LANAR, DE GORDON, DM BALLOU, WR SETTE, A HOFFMAN, SL AF WIZEL, B HOUGHTEN, R CHURCH, P TINE, JA LANAR, DE GORDON, DM BALLOU, WR SETTE, A HOFFMAN, SL TI HLA-A2-RESTRICTED CYTOTOXIC T-LYMPHOCYTE RESPONSES TO MULTIPLE PLASMODIUM-FALCIPARUM SPOROZOITE SURFACE PROTEIN-2 EPITOPES IN SPOROZOITE-IMMUNIZED VOLUNTEERS SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HIV-SEROPOSITIVE INDIVIDUALS; CLASS-I MOLECULES; CIRCUMSPOROZOITE PROTEIN; MALARIA SPOROZOITES; CELLS RECOGNIZE; SIGNAL SEQUENCE; CS PROTEIN; PEPTIDES; ANTIGEN; CD4+ AB CD8(+) CTL specific for the Plasmodium yoelii sporozoite surface protein 2 (PySSP2) protect mice against malaria. For this reason, vaccines designed to induce CTL against P. falciparum SSP2 (PfSSP2) are under development. Optimal development of PfSSP2 as a component of human malaria vaccines requires characterization of HLA class I-restricted CTL against this Ag. For this purpose, PBMC from four HLA-A2(+) human volunteers immunized with P. falciparum irradiated sporozoites were stimulated with a recombinant vaccinia virus expressing PfSSP2 and with 35 PfSSP2-derived 15-amino acid peptides containing sequences conforming to HLA-A2 binding motifs. Ag-specific, genetically restricted, CD8(+) T cell-dependent cytotoxic activity against autologous target cells transfected with the PfSSP2 gene was demonstrated in the four volunteers. Twelve of the 35 peptides sensitized HLA-A2-matched target cells for lysis by peptide-stimulated effecters. Three volunteers had CTL against 9 of the 12 peptides, and one had no peptide-specific CTL. HLA-A*0201 restriction was confirmed by demonstrating that effecters from the three responders could be stimulated with six different peptides to lyse HLA-A*0201(+) T2 cells incubated with the homologous peptides. Peptide-specific, genetically restricted, CD8(+) T cell-dependent cytotoxic activity was also demonstrated against two peptides using unstimulated PBMC as effecters. Available data indicate that the motif-bearing sequences in 6 of the 12 positive peptides are conserved among P. falciparum isolates and clones. Demonstration of HLA-A2-restricted CTL responses to multiple PfSSP2-derived peptides, and of circulating activated CTL against PfSSP2 in immune volunteers provide important information for optimal design and evaluation of vaccines containing this pre-erythrocytic stage Ag. C1 USN,MED RES INST,MALARIA PROGRAM,ROCKVILLE,MD 20852. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT MOLEC MICROBIOL & IMMUNOL,BALTIMORE,MD 21205. TORREY PINES INST MOLEC STUDIES,SAN DIEGO,CA 92121. HOUGHTEN PHARMACEUT INC,SAN DIEGO,CA 92121. VIROGENET CORP,TROY,NY 12180. WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. CYTEL CORP,SAN DIEGO,CA 92121. RI Lanar, David/B-3560-2011 NR 52 TC 58 Z9 59 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD JUL 15 PY 1995 VL 155 IS 2 BP 766 EP 775 PG 10 WC Immunology SC Immunology GA RG973 UT WOS:A1995RG97300030 PM 7541824 ER PT J AU DELACRUZ, RM TEITSWORTH, SW STROSCIO, MA AF DELACRUZ, RM TEITSWORTH, SW STROSCIO, MA TI INTERFACE PHONONS IN SPHERICAL GAAS/AL-X GA1-XAS QUANTUM DOTS SO PHYSICAL REVIEW B LA English DT Note ID RAMAN-SCATTERING; THIN-FILMS; ELECTRON; SURFACE; MICROCRYSTALLINE; HETEROSTRUCTURES; CRYSTALS; SILICON; SYSTEMS; MODES AB Within the framework of the dielectric continuum model, the interface phonon frequencies for spherical GaAs/AlxGa1-xAs quantum dots are obtained as functions of the alloy composition in the range x=0.2-1.0. By imposing electrostatic boundary conditions, the two interface phonon frequencies are calculated for the first three modes. The frequency behavior of the different modes is found to be similar. However, for each mode one of the phonon frequencies is found to be strongly dependent on x. It is demonstrated that these phonon modes play an important role in determining resonant optical absorption of quantum dots. C1 DUKE UNIV,DEPT PHYS,DURHAM,NC 27708. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP DELACRUZ, RM (reprint author), UNIV CARLOS III MADRID,DEPT INGN,E-28911 LEGANES,SPAIN. OI CRUZ, ROSA MARIA DE LA/0000-0002-6633-1676 NR 26 TC 40 Z9 40 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD JUL 15 PY 1995 VL 52 IS 3 BP 1489 EP 1492 DI 10.1103/PhysRevB.52.1489 PG 4 WC Physics, Condensed Matter SC Physics GA RL525 UT WOS:A1995RL52500020 ER PT J AU CALLAHAN, CW PERSON, DA AF CALLAHAN, CW PERSON, DA TI PREIMPLANTATION DIAGNOSIS OF THE CYSTIC-FIBROSIS DELTA-F508 MUTATION - WHAT OF THE OTHER 2 EMBRYOS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP CALLAHAN, CW (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUL 12 PY 1995 VL 274 IS 2 BP 126 EP 127 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA RH222 UT WOS:A1995RH22200013 PM 7661971 ER PT J AU VANDERGRACHT, J AF VANDERGRACHT, J TI SPATIAL-FREQUENCY NOTCHING BY SOURCE MODIFICATION SO APPLIED OPTICS LA English DT Article AB A partially coherent image-enhancement system is introduced for notching unwanted spatial frequency components. The technique offers two advantages over a more conventional coherent spatial-filtering approach. First, the method utilizes a fixed pupil mask and a dynamic source and eliminates the need for a high-optical-quality spatial light modulator. Second, the redundancy that is introduced by the source provides greatly improved immunity to the effects of optical setup noise (dust, scratches, and other imperfections on optical surfaces). Numerical simulations and a laboratory experiment support the analysis. RP VANDERGRACHT, J (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 13 TC 2 Z9 2 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 10 PY 1995 VL 34 IS 20 BP 4065 EP 4072 PG 8 WC Optics SC Optics GA RH839 UT WOS:A1995RH83900022 PM 21052229 ER PT J AU HAN, WY COLE, MW CASAS, LM JONES, KA LEE, HS WADE, M DEANNI, A LAPORE, A LU, Y YANG, LW AF HAN, WY COLE, MW CASAS, LM JONES, KA LEE, HS WADE, M DEANNI, A LAPORE, A LU, Y YANG, LW TI PDGETIPT OHMIC CONTACTS TO P(+)-ALXGA1-XAS SO APPLIED PHYSICS LETTERS LA English DT Article ID GAAS; HETEROSTRUCTURES; RESISTANCE; AU; NI C1 RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. FORD MICROELECTR INC,COLORADO SPRINGS,CO 80921. RP HAN, WY (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 10 PY 1995 VL 67 IS 2 BP 273 EP 275 DI 10.1063/1.114780 PG 3 WC Physics, Applied SC Physics GA RH056 UT WOS:A1995RH05600043 ER PT J AU WAYS, M KROENKE, K UMALI, J BUCHWALD, D AF WAYS, M KROENKE, K UMALI, J BUCHWALD, D TI MORNING REPORT - A SURVEY OF RESIDENT ATTITUDES SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID INTERNAL-MEDICINE AB Background: Morning report is a time-honored tradition of most internal medicine residency programs. Despite its ubiquity, residents' attitudes regarding morning report have not been investigated. Methods: Using a 44-item questionnaire, we surveyed residents in an academic internal medicine training program working in five teaching hospitals on the processes of teaching and learning during morning report. Results: Among 74 residents completing the survey (100%), morning report was ranked as the most valuable of six educational activities. Residents preferred discussing new cases, with time equally divided between ''great'' cases and common problems, an interactive discussion with open-ended questions, and a Socratic teaching style. Seventy-two percent stated that attending physicians should be chosen from among the best teachers. General medical knowledge (90%), an ability to ask effective questions (86%), and good interpersonal skills (84%) were identified as the most important attending physicians' attributes. Discussions of basic science, use of anecdotes, and subspecialty knowledge were not considered highly desirable characteristics. Attending physicians with limited knowledge (41%) were viewed as the major obstacle to effective teaching while provocative attending physicians (52%) were considered as being most valuable to the learning experience. Conclusions: Residents believed that the morning report was a valuable educational experience. They preferred clinically based, open-ended interactive discussions led by attending physicians with a broad knowledge base. These findings underscore the importance of morning report in general, and the role of attending physicians in particular, in medical education. C1 UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT MED,SEATTLE,WA 98104. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. NR 10 TC 36 Z9 36 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern Med. PD JUL 10 PY 1995 VL 155 IS 13 BP 1433 EP 1437 DI 10.1001/archinte.155.13.1433 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA RG052 UT WOS:A1995RG05200011 PM 7794093 ER PT J AU KOLESAR, JM KUHN, JG BURRIS, HA AF KOLESAR, JM KUHN, JG BURRIS, HA TI DETECTION OF A POINT MUTATION IN NQO1 (DT-DIAPHORASE) IN A PATIENT WITH COLON-CANCER SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Letter ID CARCINOMA CELLS; MITOMYCIN-C; OXIDOREDUCTASE; GENE C1 BROOKE ARMY MED CTR,SAN ANTONIO,TX. CANC THERAPY & RES CTR S TEXAS,SAN ANTONIO,TX 78229. RP KOLESAR, JM (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT CLIN PHARM,CLIN PHARM PROGRAM,7703 FLOYD CURL DR,SAN ANTONIO,TX 78229, USA. NR 10 TC 25 Z9 26 U1 0 U2 0 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD JUL 5 PY 1995 VL 87 IS 13 BP 1022 EP 1024 DI 10.1093/jnci/87.13.1022-a PG 3 WC Oncology SC Oncology GA RF706 UT WOS:A1995RF70600020 PM 7629875 ER PT J AU WAGNER, GW BARTRAM, PW AF WAGNER, GW BARTRAM, PW TI P-31 MAS NMR-STUDY OF THE HYDROLYSIS OF O,S-DIETHYL PHENYLPHOSPHONOTHIOATE ON REACTIVE SORBENTS SO JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL LA English DT Article DE ALUMINA; HYDROLYSIS; ION EXCHANGE RESIN; LETHAL AGENT DECONTAMINATION; MAGIC ANGLE SPINNING NMR; O,S-DIETHYL PHENYL PHOSPHONOTHIOATE; PHOSPHONOTHIOATE DERIVATIVES; P-31 NMR ID RESIN AB P-31 MAS NMR was used to monitor the hydrolysis of O,S-diethyl phenylphosphonothioate (DEPPT) sorbed on gamma-alumina, XE-555 (a mixture of strong-acid/strong-base ion exchange resins and a carbonaceous adsorbent), and a polydivinyl-benzene sorbent impregnated with NaOH. The products were identified to determine the amount of P-O/P-S bond hydrolysis occurring on the sorbents. The relative order of reactivity observed for the sorbents is: polydivinylbenzene/NaOH > gamma-alumina >> XE-555. Distinct P-31 MAS NMR peaks were observed for DEPPT sorbed on the individual components of XE-555. P-31 MAS NMR also suggested the presence of mobile and translationally-restricted phases for DEPPT sorbed on gamma-alumina. These aspects of DEPPT sorption provided by P-31 MAS NMR enabled a better understanding of the DEPPT reactivity observed on XE-555 and gamma-alumina. C1 USA,EDGEWOOD RDEC,RES & TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. RP WAGNER, GW (reprint author), GEOCENTERS INC,GUNPOWDER BRANCH,POB 68,ABERDEEN PROVING GROUND,MD 21010, USA. NR 6 TC 15 Z9 15 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1381-1169 J9 J MOL CATAL A-CHEM JI J. Mol. Catal. A-Chem. PD JUL 3 PY 1995 VL 99 IS 3 BP 175 EP 181 DI 10.1016/1381-1169(95)00054-2 PG 7 WC Chemistry, Physical SC Chemistry GA RG917 UT WOS:A1995RG91700008 ER PT J AU DEBERNARDINO, TM AF DEBERNARDINO, TM TI IN-LINE SKATERS NEED EDUCATION ABOUT IMPORTANCE OF PROTECTIVE GEAR SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material RP DEBERNARDINO, TM (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JUL PY 1995 VL 52 IS 1 BP 249 EP 249 PG 1 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA RH250 UT WOS:A1995RH25000024 ER PT J AU WEDDLE, JR CHAN, TC THOMPSON, K PAXTON, H KELLY, DJ DASCH, G STRICKMAN, D AF WEDDLE, JR CHAN, TC THOMPSON, K PAXTON, H KELLY, DJ DASCH, G STRICKMAN, D TI EFFECTIVENESS OF A DOT-BLOT IMMUNOASSAY OF ANTI-RICKETTSIA TSUTSUGAMUSHI ANTIBODIES FOR SEROLOGIC ANALYSIS OF SCRUB TYPHUS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ILLNESS AB We compared a commercially available dot-blot immunoassay system with the indirect immunofluorescence assay (IFA) in tests of known negative and known positive sera from scrub typhus cases. Using a panel of 100 sera from patients with various rickettsial and nonrickettsial infections, we observed that the IFA was 99% specific and the dipstick assay was 98% specific. In tests of 91 sera (30 negative and 61 positive for scrub typhus antibodies) from a study of febrile patients in Malaysia, using the standard of an IFA titer < 1:64 as negative, an IFA titer > 1:128 as positive, and an IFA titer = 1:64 as either positive or negative (supported by clinical records), dipsticks were 83% specific and 90% sensitive. The quantitative correlation of the dipsticks to IFA titers was confirmed by significant differences in geometric means of inverse IFA titers corresponding to the number of positive dipstick spots (no dots = 8.5, one dot = 43.3, two dots = 206.7, and three dots = 676.9). The assay would enable physicians and public health workers who deal with patients to quickly diagnose and appropriately treat most cases of the disease, especially in areas of high prevalence where the proportion of false-positve results to true-positive results would be low. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT RICKETTSIAL DIS,WASHINGTON,DC 20307. INTEGRATED DIAGNOST INC,BALTIMORE,MD 21227. RP WEDDLE, JR (reprint author), USN,MED RES INST,VIRAL & RICKETTSIAL DIS PROGRAM,8901 WISCONSIN AVE,BETHESDA,MD 20889, USA. NR 25 TC 28 Z9 29 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1995 VL 53 IS 1 BP 43 EP 46 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA RL499 UT WOS:A1995RL49900008 PM 7625532 ER PT J AU MUNOZ, C BAQAR, S VANDEVERG, L THUPARI, J GOLDBLUM, S OLSON, JG TAYLOR, DN HERESI, GP MURPHY, JR AF MUNOZ, C BAQAR, S VANDEVERG, L THUPARI, J GOLDBLUM, S OLSON, JG TAYLOR, DN HERESI, GP MURPHY, JR TI CHARACTERISTICS OF SHIGELLA-SONNEI INFECTION OF VOLUNTEERS - SIGNS, SYMPTOMS, IMMUNE-RESPONSES, CHANGES IN SELECTED CYTOKINES AND ACUTE-PHASE SUBSTANCES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID TUMOR NECROSIS FACTOR; FALCIPARUM-MALARIA; PERIPHERAL-BLOOD; SECRETING CELLS; VACCINE; HUMANS; INTERLEUKIN-1-BETA; RADIOIMMUNOASSAY; DIARRHEA; INVIVO AB Shigella sonnei infection resulting from oral administration of 500 colony-forming units was followed in 11 volunteers with the objective of studying the immune response and pathogenesis. Characterization of infection included recording of signs and symptoms, excretion of S. sonnei in stool, measurement of humoral tumor necrosis factor-alpha (TNF-(a)lpha), interleukin-1 beta (IL-1 beta), interferon-gamma (IFN-gamma), C-reactive protein, IL-2 receptor, soluble CD8, antibody-antigen complexes, and endotoxin. Measurements were also made of the immune response including lymphocytes secreting antibody to S. sonnei O antigen and serum antibody to this antigen. Six of the volunteers developed typical shigellosis with excretion of bacteria in stool and systemic signs and symptoms, three excreted bacteria but did not show illness, and two showed no evidence of infection or illness. Shigellosis was characterized by excretion in stool of S. sonnei beginning on average 1.3 days after ingestion. Excretion of S. sonnei (mean of time of the first positive cultures) was followed in sequence by the onset of increases in TNF-alpha (10 hr), liquid stools (14 hr), fever and dysentery (18 hr), IFN-gamma (22 hr), and C-reactive protein (34 hr). A S. sonnei-specific immune response was demonstrated somewhat later, between days 4 and 7 postinfection by antibody-secreting cells, and between days 7 and 14 postinfection by humoral antibody. Shigellosis was not associated with increased humoral IL-1 beta, endotoxin, or antigen-antibody complexes. C1 UNIV MARYLAND,SCH MED,DEPT MED,DIV INFECT DIS,BALTIMORE,MD 21001. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. UNIV TEXAS,HLTH SCI CTR,SCH PUBL HLTH,CTR INFECT DIS,HOUSTON,TX 77030. UNIV TEXAS,HLTH SCI CTR,SCH MED,DEPT PEDIAT,HOUSTON,TX 77030. UNIV MARYLAND,SCH MED,DEPT MED,DIV GEOG MED,BALTIMORE,MD 21201. USN,MED RES UNIT 3,ENTER PROGRAM,CAIRO,EGYPT. USN,MED RES UNIT 3,DIV CLIN INVEST,CAIRO,EGYPT. NR 36 TC 22 Z9 22 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1995 VL 53 IS 1 BP 47 EP 54 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA RL499 UT WOS:A1995RL49900009 PM 7542845 ER PT J AU SHARP, TW WALLACE, MR HAYES, CG SANCHEZ, JL DEFRAITES, RF ARTHUR, RR THORNTON, SA BATCHELOR, RA ROZMAJZL, PJ HANSON, RK WU, SJ BURANS, JP AF SHARP, TW WALLACE, MR HAYES, CG SANCHEZ, JL DEFRAITES, RF ARTHUR, RR THORNTON, SA BATCHELOR, RA ROZMAJZL, PJ HANSON, RK WU, SJ BURANS, JP TI DENGUE FEVER IN US TROOPS DURING OPERATION-RESTORE-HOPE, SOMALIA, 1992-1993 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID IDENTIFICATION; VIRUS; ASSAY AB Dengue fever (DF) was considered to be a potential cause of febrile illness in U.S. troops deployed to Somalia during Operation Restore Hope in 1992-1993. A prospective study of hospitalized troops with fever and a seroepidemiologic survey of 530 troops were conducted. Among 289 febrile troops hospitalized, 129 (45%) did not have an identified cause of their fever. Dengue (DEN) virus was recovered from 41 (43%) of 96 of these patients by inoculation of admission sera into C6/36 cell cultures. Thirty-nine (41%) of the isolates were identified as DEN-2 and two (2%) as DEN-3 by an indirect immunofluorescent antibody assay. An additional 18 (49%) of 37 culture-negative cases were shown by immunoglobulin M (IgM) antibody capture enzyme-linked immunosorbent assay to have anti-DEN virus antibody. All identified DF cases recovered within 1-2 weeks; no case of dengue hemorrhagic fever or shock syndrome was observed. A seroepidemiologic survey of a unit (n = 494) with 17 culture or serologically identified DF cases and a 13% attack rate of unidentified febrile illness revealed a 7.7% prevalence of anti-DEN virus IgM antibody. Failure to use bed nets was the only identified risk factor for DEN infection (adjusted odds ratio = 2.2, 95% confidence interval = 1.4-3.0). These data indicate that DF was an important cause of febrile illness among US troops in Somalia, and demonstrate the difficulties in preventing DEN infection in troops operating in field conditions. C1 USN,MED RES UNIT 3,CAIRO,EGYPT. USN,ENVIRONM & PREVENT MED UNIT 7,NAPLES,ITALY. USN,ENVIRONM & PREVENT MED UNIT 6,HONOLULU,HI. USN,MED CTR,OAKLAND,CA. JOHNS HOPKINS UNIV,BALTIMORE,MD. USN,MED CTR,DIV INFECT DIS,SAN DIEGO,CA 92134. WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307. USN,MED RES INST,BETHESDA,MD 20889. RP SHARP, TW (reprint author), US MARINE CORPS,HEADQUARTERS,CODE HS,2 NAVY ANNEX,ROOM 1116,WASHINGTON,DC 20380, USA. NR 21 TC 78 Z9 80 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1995 VL 53 IS 1 BP 89 EP 94 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA RL499 UT WOS:A1995RL49900017 PM 7625541 ER PT J AU COURTNEY, BC WILLIAMS, KC BING, QA SCHLAGER, JJ AF COURTNEY, BC WILLIAMS, KC BING, QA SCHLAGER, JJ TI CAPILLARY GEL-ELECTROPHORESIS AS A METHOD TO DETERMINE LIGATION EFFICIENCY SO ANALYTICAL BIOCHEMISTRY LA English DT Article ID DNA; LIBRARIES; LIGANDS; PROTEIN; PHAGE AB A capillary gel electrophoresis (CGE) method is del scribed for detection of the formation of circular DNA ligation products as an aid in the prediction of ligated DNA competent cell transformation efficiency, The separation is based upon the differences in the relative migrations of linear and circular DNA molecules of the same size, In CGE, circular ligation products are shifted significantly from linear DNA fragments of comparable size (to 40-42 min from 32-33 min migration time) in the presence of an intercalating dye, CGE separation and detection of circularized DNA can be correlated with transformation efficiencies of > 10(6) colony-forming units (CFU, colonies/mu g/ml) or the high efiEiciency desired for phagemid display and cell expression libraries, CGE has several advantages over slab gel electrophoresis: (i) only a minute quantity (similar to 250 CFU or 0.02%) of the total library is sacrificed for analysis, (ii) verification of the circularized ligation products is easier by CGE, and (iii) CGE analysis of ligation success can be accomplished in less than 2 h, prior to transforming competent cells. (C) 1996 Academic Press, Inc. C1 USA,MED RES INST CHEM DEF,APPL PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 18 TC 8 Z9 9 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD JUL 1 PY 1995 VL 228 IS 2 BP 281 EP 286 DI 10.1006/abio.1995.1351 PG 6 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA RH245 UT WOS:A1995RH24500014 PM 8572307 ER PT J AU THWAITES, BK NIGUS, DB BOUSKA, GW MONGAN, PD AYALA, EF MERRILL, GA AF THWAITES, BK NIGUS, DB BOUSKA, GW MONGAN, PD AYALA, EF MERRILL, GA TI INTRAVENOUS KETOROLAC TROMETHAMINE DOES NOT WORSEN PLATELET-FUNCTION DURING KNEE ARTHROSCOPY UNDER GENERAL-ANESTHESIA SO ANESTHESIA AND ANALGESIA LA English DT Article ID TOTAL HIP-REPLACEMENT; VASCULAR-SURGERY; TROMETAMOL; VOLUNTEERS; ANALGESIA; STRESS AB Ketorolac (KT) prolongs bleeding time and inhibits platelet aggregation and platelet thromboxane production in healthy, awake volunteers. However, platelet function may be accentuated during the stress of general anesthesia (GA) and surgery. The purpose of this study was to investigate platelet function changes during a standard GA technique and surgery, as well as after a single intraoperative dose of intravenous (IV) KT. The study comprised 30 ASA physical status I patients undergoing GA for knee arthroscopy. Subjects were randomized to receive either KT 60 mg IV 15 min after skin incision or placebo IV. Platelet function testing consisted of an Ivy bleeding time (BT), platelet aggregometry (PA) with adenosine diphosphate (ADP) and collagen, thromboelastography (TEG), and serum thromboxane B-2 assays (TxB(2)). Platelet function testing was performed: 1) 15 min prior to the induction of GA, 2) 10 min after skin incision, and 3) 45 min after administration of study drug. BT decreased significantly in the placebo group from 263 +/- 133 s (mean +/- so) preoperatively to 207 +/- 89 s postincision. BT did not change in the KT group. PA was unchanged after IV KT. TEG data was unchanged in both groups during anesthesia and surgery. TxB(2) levels decreased markedly in the KT group from 106.9 +/- 96.2 ng/mL preoperatively to 0.4 +/- 1.2 ng/mL poststudy drug, P = 0.002. Platelet function appears to be accentuated during GA and surgery as evaluated by BT in the placebo group. Further, platelet function by BT, PA, and TEG was not inhibited after IV KT despite near complete abolition of TxB(2) production. C1 BROOKE ARMY MED CTR,DEPT SURG,OPERAT SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT CLIN INVEST,FT SAM HOUSTON,TX 78234. RP THWAITES, BK (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA SERV,2450 STANLEY RD,FT SAM HOUSTON,TX 78234, USA. NR 26 TC 20 Z9 20 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD JUL PY 1995 VL 81 IS 1 BP 119 EP 124 PG 6 WC Anesthesiology SC Anesthesiology GA RF820 UT WOS:A1995RF82000024 PM 7598238 ER PT J AU MURPHY, G RAGDE, H KENNY, G BARREN, R ERICKSON, S TJOA, B BOYNTON, A HOLMES, E GILBAUGH, J DOUGLAS, T AF MURPHY, G RAGDE, H KENNY, G BARREN, R ERICKSON, S TJOA, B BOYNTON, A HOLMES, E GILBAUGH, J DOUGLAS, T TI COMPARISON OF PROSTATE-SPECIFIC MEMBRANE ANTIGEN, AND PROSTATE-SPECIFIC ANTIGEN LEVELS IN PROSTATIC-CANCER PATIENTS SO ANTICANCER RESEARCH LA English DT Article DE PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA); PROSTATE; SPECIFIC ANTIGEN (PSA); CANCER ID FLUTAMIDE WITHDRAWAL SYNDROME; IMMUNOSCINTIGRAPHY; DISEASE; MARKER AB PSA (prostate specific antigen) and PSMA (prostate specific membrane antigen) serum levels were determined in over 235 prostate cancer patients from 8 different United States clinical urological cancer centers. The clinical data were not known until after the serum assay results were shared with all participants to attempt to eliminate possible clinical bias. PSA values are useful in the clinical diagnosis and staging of prostate cancer patients, and generally fall to low values in response to effective treatment, e.g., surgery hormones, radiation, chemotherapy. PSMA values are not related to clinical stage bur if elevated can fall in response to effective treatments. In contrast, PSMA values can be elevated post-treatment in the presence of very low PSA levels (0.01 to 0.00). The elevated PSMA levels predicted a state of clinical progression or clinical resistance in most cases (> 70%). PSMA levels in this study were of better prognostic value than PSA. C1 PACIFIC NW RES FDN,SEATTLE,WA 98122. ST VINCENTS HOSP,DEPT UROL,PORTLAND,OR. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. RP MURPHY, G (reprint author), NORTHWEST HOSP,PACIFIC NW CANC FDN,120 NORTHGATE PLAZA,SUITE 205,SEATTLE,WA 98125, USA. NR 18 TC 58 Z9 58 U1 0 U2 4 PU INT INST ANTICANCER RESEARCH PI ATHENS PA EDITORIAL OFFICE 1ST KM KAPANDNTIOU-KALAMOU RD KAPANDRITI, POB 22, ATHENS 19014, GREECE SN 0250-7005 J9 ANTICANCER RES JI Anticancer Res. PD JUL-AUG PY 1995 VL 15 IS 4 BP 1473 EP 1479 PG 7 WC Oncology SC Oncology GA RT070 UT WOS:A1995RT07000054 PM 7544569 ER PT J AU CHAN, MMY GROGL, M CALLAHAN, H FONG, D AF CHAN, MMY GROGL, M CALLAHAN, H FONG, D TI EFFICACY OF THE HERBICIDE TRIFLURALIN AGAINST 4 P-GLYCOPROTEIN-EXPRESSING STRAINS OF LEISHMANIA SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Note ID DRUG-RESISTANCE; MULTIDRUG RESISTANCE; AMPLIFICATION; MEXICANA; GENE AB Drug resistance has emerged as a major obstacle to chemotherapy for many infectious diseases. Trifluralin, an antimicrotubule herbicide, is a new experimental drug for treatment of leishmaniasis. Here, we found that it was effective against two strains of Leishmania that express the multidrug-resistant genes Idmdr1 and ImpgpA and two strains that express proteins that are immunologically cross-reactive with mammalian P glycoproteins. These results suggest that trifluralin is not subject to counteractions of these multidrug resistance mechanisms of leishmania species. C1 WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP CHAN, MMY (reprint author), RUTGERS STATE UNIV,DEPT BIOL SCI,PISCATAWAY,NJ 08855, USA. NR 26 TC 11 Z9 11 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 1995 VL 39 IS 7 BP 1609 EP 1611 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA RG310 UT WOS:A1995RG31000042 PM 7492115 ER PT J AU YOUNG, PC CUOZZO, DW SEIDMAN, AJ BENSON, PM SAU, P JAMES, WD AF YOUNG, PC CUOZZO, DW SEIDMAN, AJ BENSON, PM SAU, P JAMES, WD TI WIDESPREAD LIVEDO-RETICULARIS WITH PAINFUL ULCERATIONS SO ARCHIVES OF DERMATOLOGY LA English DT Note ID CALCIPHYLAXIS; CALCIFICATION; CALCINOSIS; FAILURE C1 WALTER REED ARMY MED CTR, WASHINGTON, DC USA. RP YOUNG, PC (reprint author), DEWITT ARMY COMMUNITY HOSP, FT BELVOIR, VA 22060 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0003-987X EI 1538-3652 J9 ARCH DERMATOL JI Arch. Dermatol. PD JUL PY 1995 VL 131 IS 7 BP 786 EP 788 DI 10.1001/archderm.131.7.786 PG 3 WC Dermatology SC Dermatology GA RH814 UT WOS:A1995RH81400004 ER PT J AU VOGEL, PS CARDENAS, A ROSS, EV COBB, MW SAU, P JAMES, WD AF VOGEL, PS CARDENAS, A ROSS, EV COBB, MW SAU, P JAMES, WD TI LINEAR FOCAL ELASTOSIS SO ARCHIVES OF DERMATOLOGY LA English DT Note ID STRIAE C1 WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. NR 4 TC 12 Z9 12 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JUL PY 1995 VL 131 IS 7 BP 855 EP 856 DI 10.1001/archderm.131.7.855 PG 2 WC Dermatology SC Dermatology GA RH814 UT WOS:A1995RH81400028 PM 7611813 ER PT J AU SHANKS, GD AF SHANKS, GD TI MALARIA PREVENTION AND PROPHYLAXIS SO BAILLIERES CLINICAL INFECTIOUS DISEASES LA English DT Article ID RESISTANT FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; PYRIMETHAMINE-SULFADOXINE; DOXYCYCLINE PROPHYLAXIS; AMERICAN TRAVELERS; ENDEMIC AREA; EAST-AFRICA; MEFLOQUINE; CHLOROQUINE; PROGUANIL RP SHANKS, GD (reprint author), USA,MED RES UNIT KENYA,UNIT 64109,BOX 401,APO,AE 09831, USA. NR 80 TC 2 Z9 2 U1 0 U2 0 PU BAILLIERE TINDALL PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 1071-6564 J9 BAILLIERE CLIN INF D JI Baillieres Clin. Infect. Dis. PD JUL PY 1995 VL 2 IS 2 BP 331 EP 349 PG 19 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA RM205 UT WOS:A1995RM20500008 ER PT J AU OBUSEK, JP HOLT, KG ROSENSTEIN, RM AF OBUSEK, JP HOLT, KG ROSENSTEIN, RM TI THE HYBRID MASS-SPRING PENDULUM MODEL OF HUMAN LEG SWINGING - STIFFNESS IN THE CONTROL OF CYCLE PERIOD SO BIOLOGICAL CYBERNETICS LA English DT Article ID ARM MOVEMENTS; RELIABILITY; SPASTICITY; LOCOMOTION; REFLEX; JOINT AB Human leg swinging is modeled as the harmonic motion of a hybrid mass-spring pendulum. The cycle period is determined by a gravitational component and an elastic component, which is provided by the attachment of a soft-tissue/muscular spring of variable stiffness. To confirm that the stiffness of the spring changes with alterations in the inertial properties of the oscillator and that stiffness is relevant for the control of cycle period, we conducted this study in which the simple pendulum equivalent length was experimentally manipulated by adding mass to the ankle of a comfortably swinging leg. Twenty-four young, healthy adults were videotaped as they swung their right leg under four conditions: no added mass and with masses of 2.27, 4.55, and 6.82kg added to the ankle. Strong, linear relationships between the acceleration and displacement of the swinging leg within subjects and conditions were found, confirming the motion's harmonic nature. Cycle period significantly increased with the added mass. However, the observed increases were not as large as would be predicted by the induced changes in the gravitational component alone. These differences were interpreted as being due to increases in the active muscular stiffness. Significant linear increases in the elastic component (and hence stiffness) were demonstrated with increases in the simple pendulum equivalent length in 20 of the individual subjects, with r(2) values ranging between 0.89 and 0.99. Significant linear relationships were also demonstrated between the elastic and gravitational components in 22 subjects, with individual r(2) values between 0.90 and 0.99. This finding suggests stiffness is varied concomitantly with alterations in the inertial properties of the leg pendulum in a simplified mechanism of control. C1 USA,MED SPECIALIST CORPS,WASHINGTON,DC. GEO CENTERS RES,NEWTON,MA 02159. RP OBUSEK, JP (reprint author), BOSTON UNIV,SARGENT COLL ALLIED HLTH PROFESS,DEPT PHYS THERAPY,635 COMMONWEALTH AVE,BOSTON,MA 02215, USA. NR 35 TC 28 Z9 30 U1 0 U2 7 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-1200 J9 BIOL CYBERN JI Biol. Cybern. PD JUL PY 1995 VL 73 IS 2 BP 139 EP 147 DI 10.1007/s004220050170 PG 9 WC Computer Science, Cybernetics; Neurosciences SC Computer Science; Neurosciences & Neurology GA RQ275 UT WOS:A1995RQ27500005 PM 7662766 ER PT J AU BRUNO, JG MAYO, MW AF BRUNO, JG MAYO, MW TI A COLOR IMAGE-ANALYSIS METHOD FOR ASSESSMENT OF GERMINATION BASED ON DIFFERENTIAL FLUORESCENCE STAINING OF BACTERIAL-SPORES AND VEGETATIVE CELLS USING ACRIDINE-ORANGE SO BIOTECHNIC & HISTOCHEMISTRY LA English DT Article DE ACRIDINE ORANGE; BACTERIA; SPORES; GERMINATION; COMPUTER ANALYSIS; IMAGE ANALYSIS; FLUORESCENCE; BACILLUS ID BACILLUS-SUBTILIS SPORES; GLUCOSE-DEHYDROGENASE AB Color fluorescence image analysis of acridine orange (AO) stained germinating Bacillus subtilis var, niger bacteria revealed a cell population initially dominated by small green spores followed by the emergence of at least three additional discernible subpopulations in response to stimulation with D-glucose, These subpopulations were small, round or oblong red cells; intermediate to large metachromatic cells; and large red rods, Large green rods were rarely observed, An increase in red emissions (i.e., putative RNA synthesis) was sometimes seen as early as 90 min after exposure to D-glucose and uptake of AO at room temperature, This may represent either metabolic recovery from Quiescence or RNA synthesis associated with germination, In the absence of D-glucose, or using autoclaved bacteria in the presence of glucose, no relative increase in the red signal was observed despite hours of observation. Digital image analysis was used for relative measurement of red, green and blue signals and to correlate the size of various subpopulations with their fluorescence color emissions over time, Image analysis demonstrated a trend toward increasing size and red emission in the presence of glucose, The average Fed emission was found to be a good discriminator of the various subpopulations, while the average green emission was approximately equal among the subpopulations making it a poor discriminator, These data suggest that AO staining might be used for rapid computer-assisted discrimination of spores vs, vegetative cells. RP BRUNO, JG (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD RTE,USAF,ARMSTRONG LAB,CREWE SYST DIRECTORATE,BLDG E3549,ABERDEEN PROVING GROUND,MD 21010, USA. NR 38 TC 9 Z9 9 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1052-0295 J9 BIOTECH HISTOCHEM JI Biotech. Histochem. PD JUL PY 1995 VL 70 IS 4 BP 175 EP 184 DI 10.3109/10520299509107309 PG 10 WC Biotechnology & Applied Microbiology; Cell Biology SC Biotechnology & Applied Microbiology; Cell Biology GA TC464 UT WOS:A1995TC46400003 PM 8580199 ER PT J AU BATTAFARANO, DF ZIMMERMAN, GC OLDER, SA KEELING, JH BURRIS, HA AF BATTAFARANO, DF ZIMMERMAN, GC OLDER, SA KEELING, JH BURRIS, HA TI DOCETAXEL (TAXOTERE) ASSOCIATED SCLERODERMA-LIKE CHANGES OF THE LOWER-EXTREMITIES - A REPORT OF 3 CASES SO CANCER LA English DT Article DE DOCETAXEL; TAXOTERE; TOXICITY; SCLERODERMA; SCLERODERMA-LIKE ID PHASE-I; INTRAVENOUS-INFUSION; RP-56976; NSC-628503; ANALOG; TAXOL; TRIAL AB Background. Docetaxel (Taxotere) is a microtubul-estabilizing agent that is potentially important in chemotherapy for a variety of malignancies. Methods. A clinical study of the cutaneous reactions experienced by a group of patients receiving docetaxel chemotherapy was undertaken. Patients were examined before initiation of therapy, before and after each cycle of therapy, and were followed subsequent to the completion of docetaxel chemotherapy. Results. Three patients developed diffuse lower extremity edema (3-18 kg) and subsequent scleroderma-like changes after receiving multiple cycles of docetaxel therapy. These patients had different underlying malignancies and dissimilar prior therapy. Rheumatoid factor, antinuclear antibodies, anticentromere, and topoisomerase antibodies were not present in any patient. The diffuse lower extremity edema did not resolve with diuretic therapy. Cutaneous biopsies in two patients revealed diffuse sclerosis. One patient had a normal lymphangiogram during the edematous phase. Discontinuation of docetaxel correlated with resolution of edema and softening of the skin. Conclusion. The etiology of the scleroderma-like skin changes is unclear but appears to be either a toxic effect of docetaxel or an effect of polysorbate 80 (Tween 80), the vehicle for docetaxel. C1 BROOKE ARMY MED CTR,DERMATOL SERV,SAN ANTONIO,TX. BROOKE ARMY MED CTR,ONCOL SERV,SAN ANTONIO,TX. RP BATTAFARANO, DF (reprint author), BROOKE ARMY MED CTR,DEPT MED,RHEUMATOL SERV,SAN ANTONIO,TX 78234, USA. NR 15 TC 46 Z9 46 U1 0 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD JUL 1 PY 1995 VL 76 IS 1 BP 110 EP 115 DI 10.1002/1097-0142(19950701)76:1<110::AID-CNCR2820760117>3.0.CO;2-9 PG 6 WC Oncology SC Oncology GA RD897 UT WOS:A1995RD89700016 PM 8630861 ER PT J AU MCCARTY, MJ VUKELJA, SJ BANKS, PM WEISS, RB AF MCCARTY, MJ VUKELJA, SJ BANKS, PM WEISS, RB TI ANGIOFOLLICULAR LYMPH-NODE HYPERPLASIA (CASTLEMANS DISEASE) SO CANCER TREATMENT REVIEWS LA English DT Review ID SYSTEMIC LYMPHOPROLIFERATIVE DISORDER; HYALINE-VASCULAR TYPE; PLASMA-CELL VARIANT; FUKASE POEMS SYNDROME; PERIPHERAL NEUROPATHY; MORPHOLOGIC FEATURES; SKIN CHANGES; ELEVATED INTERLEUKIN-6; NEPHROTIC SYNDROME; M PROTEIN AB This review provides a comprehensive assessment of angiofollicular lymph node hyperplasia (ALNH) or Castleman's disease including pathogenesis, clinical presentation, histomorphologic and immunophenotypic findings, laboratory results, treatment, and prognoses. A division of ALNH into clinically relevant subtypes provides a framework for the consideration of the disorder. A comprehensive search of the medical literature involving ALNH using Medline was performed. Reports judged to be significant for the understanding of the disorder were analyzed and their findings incorporated into this review. ALNH is divided into localized/unicentric ALNH and generalized/multicentric ALNH due to the profound clinical differences seen between these variants. Localized/unicentric ALNH is separated by clinical and histomorphologic criteria into hyaline-vascular (HV) and plasma-cell (PC) subtypes. Generalized/multicentric ALNH may be divided by clinical criteria into generalized/multicentric ALNH without neuropathy (non-neuropathic) and generalized/multicentric ALNH with neuropathy (POEMS-associated or neuropathic). The dichotomy between these two subtypes is not absolute, with considerable clinical overlap occurring among patients presenting with generalized disease. Immunophenotypic and molecular probe studies demonstrate clonal B-cell lymphocyte populations in some cases, particularly those with generalized/multicentric ALNH. However, the finding of clonal populations is of no value in predicting malignant clinical progression. We conclude that using th is division of ALNH, patients presenting with symptoms and histomorphology consistent with ALNH can be subdivided into the appropriate category of ALNH. Localized or unicentric disease, either HV or PC subtype, has an excellent prognosis with surgery being curative in the majority of cases, Generalized or multicentric disease indicates a poor prognosis with short survival, with the neuropathic variant possessing resistance to steroids and chemotherapy and a corresponding worse prognosis. C1 BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,SAN ANTONIO,TX 78284. WALTER REED ARMY MED CTR,DEPT MED,MED ONCOL SECT,WASHINGTON,DC 20307. NR 109 TC 78 Z9 94 U1 0 U2 4 PU W B SAUNDERS CO LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0305-7372 J9 CANCER TREAT REV JI Cancer Treat. Rev. PD JUL PY 1995 VL 21 IS 4 BP 291 EP 310 DI 10.1016/0305-7372(95)90034-9 PG 20 WC Oncology SC Oncology GA RZ736 UT WOS:A1995RZ73600001 PM 7585657 ER PT J AU LAIRD, JR SLACK, MC GURCZAK, P GORMAN, PD WORTHAM, DC AF LAIRD, JR SLACK, MC GURCZAK, P GORMAN, PD WORTHAM, DC TI SPRING COIL EMBOLIZATION OF A PATENT DUCTUS-ARTERIOSUS IN AN ADULT SO CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY LA English DT Note DE COIL OCCLUSION; DELIVERY TECHNIQUE; PATENT DUCTUS ARTERIOSUS AB To date, coil embolization has been reserved for occlusion of the small patent ductus arteriosus (PDA) because of potential dislodgement of the coils. We report a case of a larger, hemodynamically significant PDA in an adult which was successfully closed by two spring coils using a ''crossed catheter'' technique for coil delivery. RP LAIRD, JR (reprint author), WALTER REED ARMY MED CTR,SERV CARDIOL,WASHINGTON,DC 20307, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0174-1551 J9 CARDIOVASC INTER RAD JI Cardiovasc. Interv. Radiol. PD JUL-AUG PY 1995 VL 18 IS 4 BP 259 EP 261 PG 3 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA RN405 UT WOS:A1995RN40500012 PM 8581909 ER PT J AU EBERSOLE, DG RUBAL, BJ AF EBERSOLE, DG RUBAL, BJ TI HIGH BALLOON DILATATION PRESSURES IN PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY ARE NOT ASSOCIATED WITH HIGHER RATE OF SIGNIFICANT COMPLICATIONS SO CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS LA English DT Article DE ANGIOPLASTY; INTERVENTION; RESULTS ID INFLATION PRESSURE; RESTENOSIS; PREDICTORS; WOMEN; SIZE AB To examine the results of high balloon dilatation pressures during percutaneous transluminal coronary angioplasty (PTCA), we retrospectively reviewed 482 angioplasty cases from our institution and divided them into three groups by the peak inflation pressure used during the procedure. Group one was defined by inflation pressures of 1-6 atmospheres (atm), group two by 7-12 atm, and group three by 13-20 atm. There were 166 patients in group 1 (34.4%), 235 in group 2 (48.8%), and 81 (16.8%) in group 3. The success rates were not statistically different; 90% in group 1, 96% in group 2, and 95% in group 3. Large dissections occurred in 27 patients in group 1 (16.3%), 19 in group 2 (8.1%), and 4 (4.9%) in group 3 (P > 0.006). There were no differences in the rates of death (1.2% vs. 0.9% vs. 1.2%), myocardial infarction (3.0% vs. 1.3% vs. 3.7%), or in-hospital CABG (3.0% vs. 1.7% vs. 1.2%) in groups 1, 2, and 3, respectively. Six-mo target vessel revascularization rates also were not different: 19% vs. 13% vs. 18%. In summary, selectively using high balloon pressures during PICA does not result in increased complications. (C) 1995 Wiley-Liss, Inc. RP EBERSOLE, DG (reprint author), BROOKE ARMY MED CTR,DEPT MED,HSHE MDC,SERV CARDIOL,FT SAM HOUSTON,TX 78234, USA. NR 16 TC 1 Z9 1 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-6569 J9 CATHETER CARDIO DIAG JI Catheter. Cardiovasc. Diagn. PD JUL PY 1995 VL 35 IS 3 BP 198 EP 202 DI 10.1002/ccd.1810350306 PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA RG840 UT WOS:A1995RG84000005 PM 7553821 ER PT J AU CARDELLO, AV AF CARDELLO, AV TI SENSORY EVALUATION AND FOOD-PACKAGING SO CEREAL FOODS WORLD LA English DT Editorial Material RP CARDELLO, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 13 TC 2 Z9 2 U1 0 U2 0 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD JUL PY 1995 VL 40 IS 7 BP 502 EP 504 PG 3 WC Food Science & Technology SC Food Science & Technology GA RG396 UT WOS:A1995RG39600008 ER PT J AU SHAFFER, RE SMALL, GW COMBS, RJ KNAPP, RB KROUTIL, RT AF SHAFFER, RE SMALL, GW COMBS, RJ KNAPP, RB KROUTIL, RT TI EXPERIMENTAL-DESIGN PROTOCOL FOR THE PATTERN-RECOGNITION ANALYSIS OF BANDPASS FILTERED FOURIER-TRANSFORM INFRARED INTERFEROGRAMS SO CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS LA English DT Article ID PIECEWISE-LINEAR DISCRIMINANTS; FT-IR INTERFEROGRAMS; DOMAIN ANALYSIS; OPTIMIZATION AB Signal processing techniques are described for open path Fourier transform infrared (FTIR) measurements that overcome fundamental limitations in conventional data analysis strategies. Bandpass digital filters are applied directly to FTIR interferograms to isolate spectral frequencies of interest, followed by pattern recognition analysis of segments of the filtered interferogram to provide an automated means for detecting a target analyte. In this work, four experimental variables are significant: (1) interferogram segment length, (2) interferogram segment position, (3) filter bandpass position, and (4) filter bandpass width. The limit of detection of a compound is directly related to the ability to choose optimal settings for these variables. Laboratory data collected when SF6 was present in the optical path of the spectrometer are employed to perform a full factorial experimental design study of these four variables. Analysis of variance techniques are employed to provide a statistical means of interpreting the main and interaction effects existing among the variables. Based on these results, a protocol for designing a near-optimal bandpass filter is developed. Interferogram segment starting position, filter bandpass position, and filter bandpass width interaction effects are found to be statistically significant. It is concluded that these factors must be optimized jointly. Interferogram segment length is found to have the most overall influence on detection performance, but can be studied independently from the other variables. To validate the filter generation protocol developed with the laboratory data, additional work is performed with open path SF6 data collected during a series of field trials. The results of this study demonstrate that the protocol is valid and can be extended to develop detection schemes for other compounds. C1 OHIO UNIV, CLIPPINGER LABS, DEPT CHEM, CTR INTELLIGENT CHEM INSTRUMENTAT, ATHENS, OH 45701 USA. USA, CTR DEV & ENGN, ABERDEEN PROVING GROUND, MD 21010 USA. RI Shaffer, Ronald/I-2134-2012 NR 29 TC 19 Z9 19 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-7439 EI 1873-3239 J9 CHEMOMETR INTELL LAB JI Chemometrics Intell. Lab. Syst. PD JUL PY 1995 VL 29 IS 1 BP 89 EP 108 DI 10.1016/0169-7439(95)00023-P PG 20 WC Automation & Control Systems; Chemistry, Analytical; Computer Science, Artificial Intelligence; Instruments & Instrumentation; Mathematics, Interdisciplinary Applications; Statistics & Probability SC Automation & Control Systems; Chemistry; Computer Science; Instruments & Instrumentation; Mathematics GA RJ655 UT WOS:A1995RJ65500009 ER PT J AU MITCHELL, WR BURROWS, EP AF MITCHELL, WR BURROWS, EP TI NITROREDUCTION OF 2,4-DINITROTOLUENE IN-VITRO BY CYTOCHROME-P-450 INDUCED H4IIE CELLS SO CHEMOSPHERE LA English DT Article ID METABOLISM AB Conditions have been established for H4IIE rat hepatoma cell cultures in which effects of cytochrome P-450 induction on the metabolism of a munitions wastestream pollutant can be studied. Under these conditions,the polychlorinated hydrocarbon 2,3,4,7,8-pentachlorodibenzfuran (PCDBF) induced cytochrome P-450 (1A1) aryl hydrocarbon hydroxy]ase (AHH) activity over a wide range of concentrations without significant cytotoxic effects. The munition pollutant 2,4-dinitrotoluene (2,4-DNT) did not induce AHH activity itself, but its metabolism was considerably altered when applied to PCDBF induced cultures. Production of amino nitrotoluene isomers was greatly enhanced in induced cultures as compared to uninduced controls, as was the conversion of radiolabeled 2,4-DNT to relatively more polar metabolites. To some extent, the results with H4IIE cells parallel those reported for animals exposed to 2,4-DNT after induction of cytochrome P-450 AHH activity. The preliminary findings suggest that with further development and validation, H4IIE cultures could be of use in characterizing metabolites that result from exposure to chemical mixtures involving a P-450 (1A1) inducer. RP MITCHELL, WR (reprint author), USA,ENVIRONM HYG AGCY,HLTH EFFECTS RES BRANCH,FT DETRICK,MD 21702, USA. NR 10 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD JUL PY 1995 VL 31 IS 2 BP 2767 EP 2777 DI 10.1016/0045-6535(95)00141-T PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA RL927 UT WOS:A1995RL92700016 PM 7663953 ER PT J AU LOW, LL HARRINGTON, GR STOLTZFUS, DP AF LOW, LL HARRINGTON, GR STOLTZFUS, DP TI THE EFFECT OF ARTERIAL LINES ON BLOOD-DRAWING PRACTICES AND COSTS IN INTENSIVE-CARE UNITS SO CHEST LA English DT Article DE ARTERIAL LINES; BLOOD LOSS; BLOOD TESTS; COSTS; CRITICAL CARE; PHLEBOTOMY ID LABORATORY TESTS; CONSERVATION AB Study objective: To determine whether the presence of an indwelling arterial access line leads to differences in blood-drawing practices and costs, in patients with similar APACHE II scores, in the ICU. Design: Prospective, observational. Setting: Adult surgical and medical ICUs at a large military tertiary care hospital. Patients: Twenty-five adult tie, above 18 years old) patients with arterial access lines and 25 adult patients without arterial access lines. Each had APACHE II of 9 to 20 and none had any central venous access. Measurements and results: A survey of the arterial line blood-drawing habits of critical care nurses at our hospital revealed a 2.99-mL mean discard blood volume to clear an arterial line, with only 9.4% not discarding any blood. For each patient enrolled in the study, the number of blood tests and blood draws were recorded during the first two 24-h periods after admission to the ICU. The amount of blood required by the laboratory for each blood test was totalled. In the arterial line group, the mean discard volume was added to the total for each blood-drawing procedure. Increases were found in the number of blood tests (29% increase, p = 0.013), blood-drawing procedures (30% increase, p = 0.014), and the amount of blood volume (44% increase, p < 0.001) sent from patients with arterial lines compared to those without. Conclusion: When APACHE II scores are similar, the presence of an arterial access line may lead to increased blood drawing from patients in ICUs. C1 WALTER REED ARMY MED CTR,DEPT MED,CRIT CARE MED SERV,WASHINGTON,DC 20307. NR 14 TC 31 Z9 34 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD JUL PY 1995 VL 108 IS 1 BP 216 EP 219 DI 10.1378/chest.108.1.216 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA RJ222 UT WOS:A1995RJ22200041 PM 7606961 ER PT J AU FAIRCHOK, MP ROUSE, JH MORRIS, SL AF FAIRCHOK, MP ROUSE, JH MORRIS, SL TI AGE-DEPENDENT HUMORAL RESPONSES OF CHILDREN TO MYCOBACTERIAL ANTIGENS SO CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY LA English DT Article ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; EASTERN-UNITED-STATES; AVIUM COMPLEX DISEASE; NONTUBERCULOUS MYCOBACTERIA; INTRACELLULARE COMPLEX; INFECTED CHILDREN; SWEDISH CHILDREN; AIDS; EPIDEMIOLOGY; ANTIBODIES AB In the United States, disseminated infection with environmental mycobacteria, including the Mycobacterium avium complex, is the most common opportunistic bacterial infection seen in AIDS patients. However, the source and relative degree of exposure to environmental mycobacteria during childhood are unknown. To examine the age-related exposure to mycobacteria, we obtained serum samples from 150 children ranging in age from 6 months to 18 years, Each sample was tested against both M, avium (serovar 1) sonic extracts and mycobacterial lipoarabinomannan, using an enzyme-linked immunosorbent assay (ELISA). All serum samples were also subjected to immunoblot analysis with the sonic extract antigen. These studies established that elevated ELISA values (P < 0.0901) and increased immunoblot reactivity (P < 0.0001) against mycobacterial antigens were both associated with increasing age. The seroreactivity differences were most striking when comparing the age groups of children below the age of 6,vith the older age groups. Our results suggest that the development of humoral immune responses to mycobacterial antigens in children correlates with increasing age and that there may be an environmental factor predisposing to mycobacterial exposure which is related to advancing age. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. US FDA,CTR BIOL EVALUAT & RES,DIV BACTERIAL PROD,BETHESDA,MD 20892. NR 47 TC 19 Z9 19 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 1071-412X J9 CLIN DIAGN LAB IMMUN JI Clin. Diagn. Lab. Immunol. PD JUL PY 1995 VL 2 IS 4 BP 443 EP 447 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RJ987 UT WOS:A1995RJ98700011 PM 7583921 ER PT J AU KRAKAUER, T AF KRAKAUER, T TI LEVELS OF INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR IN SERUM FROM HUMANS VACCINATED WITH LIVE, ATTENUATED FRANCISELLA-TULARENSIS SO CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY LA English DT Note ID GAMMA-INTERFERON; TULAREMIA; IMMUNITY; ANTIBODIES; INFECTION; INVITRO AB The levels of interleukin 6 (IL-6) and tumor necrosis factor alpha in serum did not change significantly during the course of immunization with the live vaccine strain of Francisella tularensis. Higher levels of circulating IL-6 were found in the sera of vaccinees with good antibody responses than in the sera from nonresponders. Preimmunization levels of IL-6 in serum were also higher in responders than in nonresponders. RP KRAKAUER, T (reprint author), USA,MED RES INST INFECT DIS,DIV APPL RES,BLDG 1425,FREDERICK,MD 21702, USA. NR 10 TC 13 Z9 13 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 1071-412X J9 CLIN DIAGN LAB IMMUN JI Clin. Diagn. Lab. Immunol. PD JUL PY 1995 VL 2 IS 4 BP 487 EP 488 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RJ987 UT WOS:A1995RJ98700020 PM 7583930 ER PT J AU SHLIM, DR HOGE, CW RAJAH, R RABOLD, JG ECHEVERRIA, P AF SHLIM, DR HOGE, CW RAJAH, R RABOLD, JG ECHEVERRIA, P TI IS BLASTOCYSTIS-HOMINIS A CAUSE OF DIARRHEA IN TRAVELERS - A PROSPECTIVE CONTROLLED-STUDY IN NEPAL SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID FOREIGN RESIDENTS; EPIDEMIOLOGY; INFECTION; PATHOGENICITY; PREVALENCE; ORGANISM; DISEASE AB Although the pathogenicity of Blastocystis hominis has been extensively debated in the medical literature, controlled studies of the association between B. hominis and diarrhea are lacking. We conducted a case-control study among expatriates and tourists in Kathmandu, Nepal, in which we compared the prevalence of the organism among patients with diarrhea to that among a control group without diarrhea. B. hominis was detected in 56 (30%) of 189 patients with diarrhea, compared with 40 (36%) of 112 asymptomatic controls. Patients with diarrhea were significantly more likely to have greater than or equal to 10 B. hominis organisms per high-power (400x) field than were controls. However, among the 25 patients with this concentration of organisms, other enteric pathogens were detected in 17 (68%). Only 8 (4%) of 189 patients with diarrhea had greater than or equal to 10 B. hominis organisms per high-power field detected in the absence of other pathogens, compared with 5 (5%) of 112 asymptomatic controls. Thus, B. hominis in higher concentrations was not associated with diarrhea. There were no specific symptoms associated with B. hominis infection, and the presence of higher concentrations of the organism in stool was not associated with more-severe symptoms. Despite the high prevalence of the organism among travelers and expatriates in Nepal, the results of this study suggest that B. hominis does not cause diarrhea in this population. C1 ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. RP SHLIM, DR (reprint author), CANADIAN INT WATER & ENERGY CONSULTANTS CLIN,POB 1340,KATMANDU,NEPAL. NR 24 TC 54 Z9 59 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUL PY 1995 VL 21 IS 1 BP 97 EP 101 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RG595 UT WOS:A1995RG59500016 PM 7578767 ER PT J AU SCHRANK, JH DOOLEY, DP AF SCHRANK, JH DOOLEY, DP TI PURULENT PERICARDITIS CAUSED BY CANDIDA SPECIES - CASE-REPORT AND REVIEW SO CLINICAL INFECTIOUS DISEASES LA English DT Review ID CONSECUTIVE OPERATIVE PROCEDURES; AMPHOTERICIN-B; FUNGAL PERICARDITIS; RISK-FACTORS; EXPERIENCE; INFECTIONS; DIAGNOSIS; THERAPY; EPIDEMIOLOGY; MANAGEMENT AB Purulent pericarditis caused by Candida species is a rare and often undiagnosed disease. We recently treated a patient in whom purulent pericarditis due to Candida albicans developed following thoracic surgery, The patient survived after receiving a combination of surgical and medical therapy. A literature review revealed 24 additional cases of purulent pericarditis caused by Candida species. Twenty-one of the patients either had undergone thoracic surgery or had had disseminated candidiasis. None of the 12 patients described before 1980 survived, whereas six (46%) of the 13 patients described after 1980 survived, No patient survived without pericardiectomy (five of six survivors) or at least pericardiocentesis (one survivor). Ah survivors received full courses of amphotericin B therapy. An increased utilization of echocardiography, along with an increased recognition of the patient populations at risk, has been instrumental in early detection and improved outcome of purulent pericarditis. A combination of prolonged amphotericin B therapy and pericardiectomy appears to be the best approach for achieving a cure. C1 BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234. RP SCHRANK, JH (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,DEPT MED,INFECT DIS SERV,FT GORDON,GA 30905, USA. NR 40 TC 21 Z9 21 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUL PY 1995 VL 21 IS 1 BP 182 EP 187 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RG595 UT WOS:A1995RG59500029 PM 7578728 ER PT J AU HODGES, LF KOOPER, R MEYER, TC ROTHBAUM, BO OPDYKE, D DEGRAAFF, JJ WILLIFORD, JS NORTH, MM AF HODGES, LF KOOPER, R MEYER, TC ROTHBAUM, BO OPDYKE, D DEGRAAFF, JJ WILLIFORD, JS NORTH, MM TI VIRTUAL ENVIRONMENTS FOR TREATING THE FEAR OF HEIGHTS SO COMPUTER LA English DT Article ID PHOBIC PATIENTS; EXPOSURE AB Since the spring of 1993, the authors have been investigating the possibility of using virtual environments to conduct exposure therapy of individuals with psychological disorders. They describe their pilot study, which used virtual reality graded exposure techniques to treat acrophobia-the fear of heights. Two main issues are addressed: the extent to which subjects felt actually present in height situations, and the efficacy of the treatment conducted using virtual height situations. Acrophobia, a simple phobia, is characterized by marked anxiety upon exposure to heights, by avoidance of heights, and by interference in functioning as a result of this fear. Behavioral therapy of acrophobia has included exposing the subject to anxiety-producing stimuli while allowing this anxiety to attenuate. In vivo graded exposure is a common and effective treatment for acrophobia. For example, if a patient is afraid of heights, therapy sessions might begin by having the patient look through a third floor window with the therapist present. In subsequent sessions, the patient might move up to a window on the tenth floor. Other common locations for in vivo therapy are outside stairways, balconies, bridges, and elevators. The authors designed a number of virtual height situations to correspond to the types used for in vivo stimuli. The study yielded remarkable results, in particular, the sense of presence experienced by subjects. Subjects experienced a range of physical anxiety symptoms consistent with the apparent threat they encountered. Subject responses were also apparently modified, as evidenced by the decrease in anxiety, avoidance, and negative attitudes toward heights. The results also support the notion that more elements of the fear structure are changed than those directly addressed in therapy. C1 EMORY UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,ATLANTA,GA. UNIV LONDON QUEEN MARY & WESTFIELD COLL,LONDON,ENGLAND. GEORGIA STATE UNIV,ATLANTA,GA 30303. USA,DIV AIRBORNE 101ST,FT CAMPBELL,KY. CLARK ATLANTA UNIV,DEPT COMP & INFORMAT SCI,ATLANTA,GA 30314. RP HODGES, LF (reprint author), GEORGIA INST TECHNOL,COLL COMP,CTR GRAPH VISUALIZAT & USABIL,801 ATLANTIC DR,ATLANTA,GA 30332, USA. OI Kooper, Rob/0000-0002-5781-7287 NR 20 TC 68 Z9 70 U1 0 U2 15 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 SN 0018-9162 J9 COMPUTER JI Computer PD JUL PY 1995 VL 28 IS 7 BP 27 EP 34 DI 10.1109/2.391038 PG 8 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA RG242 UT WOS:A1995RG24200010 ER PT J AU CARDONE, JS VINSON, R ANDERSON, LL AF CARDONE, JS VINSON, R ANDERSON, LL TI COCCIDIOIDOMYCOSIS - THE OTHER GREAT IMITATOR SO CUTIS LA English DT Article ID ITRACONAZOLE THERAPY AB A ''great imitator,'' like the perhaps more familiar syphilis and tuberculosis, coccidioidomycosis has a wide variety of clinical presentations. A recent dramatic surge in the incidence of this saprobe increases the likelihood that clinicians will encounter an infected patient. Although rare, the disseminated form of the disease is potentially fatal. Vigilance and familiarity with the many faces of this pathogen will permit early detection and treatment. We present two cases of disseminated coccidioidomycosis and briefly review this increasingly common fungal infection. C1 BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,FT SAM HOUSTON,TX. RP CARDONE, JS (reprint author), DARNALL ARMY COMMUNITY HOSP,DEPT MED,DERMATOL SERV,FT HOOD,TX 76544, USA. NR 13 TC 5 Z9 5 U1 0 U2 0 PU EXCERPTA MEDICA INC PI BELLE MEAD PA 105 RAIDER BLVD, BELLE MEAD, NJ 08502 SN 0011-4162 J9 CUTIS JI Cutis PD JUL PY 1995 VL 56 IS 1 BP 33 EP 36 PG 4 WC Dermatology SC Dermatology GA RK584 UT WOS:A1995RK58400006 PM 7555099 ER PT J AU LIU, L HUDGINS, WR MILLER, AC CHEN, LC SAMID, D AF LIU, L HUDGINS, WR MILLER, AC CHEN, LC SAMID, D TI TRANSCRIPTIONAL UP-REGULATION OF TGF-ALPHA BY PHENYLACETATE AND PHENYLBUTYRATE IS ASSOCIATED WITH DIFFERENTIATION OF HUMAN-MELANOMA CELLS SO CYTOKINE LA English DT Article ID GROWTH-FACTOR-ALPHA; MESSENGER-RNA; EXPRESSION; ACID; RECEPTORS; FIBROBLASTS; INDUCTION; ARREST AB The aromatic fatty acids phenylacetate (PA) and phenylbutyrate (PB) induce tumour cell differentiation in experimental models and both are currently in clinical trials. The purpose of this study was to determine the effect of these antitumour agents on the expression of transforming growth factor-alpha (TGF-alpha) in neoplastic cells. Treatment of human melanoma 1011 cultures with either PA or PB caused over 40-fold increase in TGF-alpha biosynthesis and secretion into the media. Whereas elevation in TGF-alpha mRNA steady-state levels became evident within 6-12 h and reached peak quantities the following day, the amounts of its coded protein increased gradually over a period of 5 days of treatment. Further molecular analysis revealed that regulation of TGF-alpha expression occurred at the transcriptional level. In contrast to TGF-alpha, expression of its receptor remained below detectable levels, indicating that an autocrine loop involving this growth factor is unlikely. Interestingly, the increase in TGF-alpha production paralleled drug-induced cytostasis and differentiation defined by morphological changes and increased melanogenesis. Like PA and PB, other differentiation inducers such as all-trans-retinoic acid, dimethyl sulfoxide, and 5-aza-2'-deoxycytidine, all induced TGF-alpha expression in the melanoma cells. The close association between enhanced TGF-alpha production and melanoma cell differentiation suggests that this growth factor, often linked to mitogenesis, may play a novel role in tumour differentiation by PA and PB. (C) 1995 Academic Press Limited. C1 NCI,CLIN PHARMACOL BRANCH,BETHESDA,MD 20892. USA,RADIAT RES INST,DEPT RADIAT BIOCHEM,BETHESDA,MD. NR 43 TC 21 Z9 24 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 1043-4666 J9 CYTOKINE JI Cytokine PD JUL PY 1995 VL 7 IS 5 BP 449 EP 456 DI 10.1006/cyto.1995.0061 PG 8 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA RJ230 UT WOS:A1995RJ23000008 PM 7578983 ER PT J AU MAGILL, AJ AF MAGILL, AJ TI EPIDEMIOLOGY OF THE LEISHMANIASES SO DERMATOLOGIC CLINICS LA English DT Review AB The leishmaniases are a group of zoonotic infections caused by protozoan parasites of the genus Leishmania. These infections produce a variety of different clinical diseases depending on the virulence or tropism of the parasite and differential host immune responses. Newly recognized clinical presentations, such as viscerotropic leishmaniasis in American military veterans of Operation Desert Storm, continue to challenge clinicians. Epidemics of classic visceral leishmaniasis leading to thousands of deaths are ongoing in Brazil, India, and the Sudan. Epidemics of localized cutaneous leishmaniasis are ongoing in many areas of South America, North Africa, and Central Asia. A marked increase in cases is often associated with an influx of nonimmune populations into newly cleared agricultural areas or population expansion into previously unsettled areas surrounding cities. The emergence of leishmaniasis as an important opportunistic infection in AIDS patients portends an ominous future as the HIV pandemic sweeps into the hyperendemic areas of South America, Africa, and the Indian subcontinent. Parenteral transmission via needle sharing in HIV coinfected individuals in Spain is an epidemiologically significant new mode of transmission. Finally, recent work has elucidated an enzootic transmission cycle involving L. mexicana in Texas. RP MAGILL, AJ (reprint author), WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307, USA. NR 0 TC 63 Z9 67 U1 0 U2 3 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0733-8635 J9 DERMATOL CLIN JI Dermatol. Clin. PD JUL PY 1995 VL 13 IS 3 BP 505 EP 523 PG 19 WC Dermatology SC Dermatology GA RK278 UT WOS:A1995RK27800002 PM 7554500 ER PT J AU ODONNELL, MBP MULVANEY, MJ JAMES, CWD MCMARLIN, CSL AF ODONNELL, MBP MULVANEY, MJ JAMES, CWD MCMARLIN, CSL TI THIN TANGENTIAL EXCISION OF TATTOOS SO DERMATOLOGIC SURGERY LA English DT Article ID REMOVAL; LASER AB BACKGROUND. There are many techniques used to remove professional tattoos. Each method can be complicated by hypertrophic scarring, pigmentary changes, and/or insufficient pigment removal. OBJECTIVE. TO study the results of precise, thin, tangential excisions of professional tattoos. The posttreatment migration of dermal tattoo pigment was also evaluated. METHODS. Five healthy white males had their professionally placed tattoos excised at a depth of 0.008 in (0.2 mm) using a Brown dermatome. Pre- and posttreatment biopsies were used to measure the depth of the tattoo pigment. RESULTS. At 3 months posttreatment, four patients had no significant scarring and three patients retained only scattered flecks of tattoo pigment. Each patient demonstrated migration of the deeper dermal pigment to a more superficial level. CONCLUSION. A superficial, tangential excision of a professional tattoo by a Brown dermatome is a viable, low-risk, inexpensive procedure. C1 MADIGAN ARMY MED CTR,DERMATOL SERV,TACOMA,WA 98431. WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC. NR 21 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD JUL PY 1995 VL 21 IS 7 BP 601 EP 603 PG 3 WC Dermatology; Surgery SC Dermatology; Surgery GA RJ703 UT WOS:A1995RJ70300005 ER PT J AU PIERSON, LL GERHARDT, KJ GRIFFITHS, SK ABRAMS, RM AF PIERSON, LL GERHARDT, KJ GRIFFITHS, SK ABRAMS, RM TI AUDITORY BRAIN-STEM RESPONSE IN SHEEP .1. FETAL DEVELOPMENT SO DEVELOPMENTAL PSYCHOBIOLOGY LA English DT Article ID EVOKED-POTENTIALS; STEM RESPONSES; POSTNATAL-DEVELOPMENT; SOUND ENVIRONMENT; PREMATURE-INFANTS; HEARING; INUTERO; LATENCY AB The Auditory Brainstem Response (ABR) was recorded from fetal sheep in utero between gestational ages of 111 days and 136 days (Normal gestation is 145 days). The ABR was detected at 111 days gestation (dGA) and morphology of the waveform improved rapidly from 116 to 123 dGA. At 123 dGA, the four vertex-positive peaks were similar to those observed in adult ewes. Thresholds of the ABR to clicks and tone bursts improved rapidly between 111 and 123 dGA. From 123 to 136 dGA, ABR thresholds continued to improve, but at a much slower rate. Latencies for the peaks also decreased during development from 111 to 136 days, with latencies for Waves III and IV showing a greater decrease than latencies for Waves I and II. (C) 1995 John Wiley and Sons, Inc. C1 UNIV FLORIDA,DEPT COMMUN PROC & DISORDERS,GAINESVILLE,FL 32611. UNIV FLORIDA,INST ADV STUDY COMMUN PROC,GAINESVILLE,FL 32611. USA,RES LAB,HUMAN RES & ENGN DIRECTORATE,ABERDEEN PROVING GROUND,MD. UNIV FLORIDA,DEPT OBSTET & GYNECOL,GAINESVILLE,FL 32611. FU NICHD NIH HHS [HD20084] NR 34 TC 16 Z9 16 U1 0 U2 1 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0012-1630 J9 DEV PSYCHOBIOL JI Dev. Psychobiol. PD JUL PY 1995 VL 28 IS 5 BP 293 EP 305 DI 10.1002/dev.420280505 PG 13 WC Developmental Biology; Psychology SC Developmental Biology; Psychology GA RF110 UT WOS:A1995RF11000004 PM 7672461 ER PT J AU COULOMBE, RA SHARMA, RP HUGGINS, JW AF COULOMBE, RA SHARMA, RP HUGGINS, JW TI PHARMACOKINETICS OF THE ANTIVIRAL AGENT 3-DEAZANEPLANOCIN-A SO EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS LA English DT Article DE 3-DEAZANEPLANOCIN A; PHARMACOKINETICS ID S-ADENOSYLHOMOCYSTEINE HYDROLASE; ADENOSINE-ANALOGS; 3-DEAZAADENOSINE; INHIBITOR; CELLS; POTENT AB The pharmacokinetics of 3-deazaneplanocin A (c(3)Nep), a competitive inhibitor of S-adenosyl-L-homocysteine (AdoHcy) hydrolase and novel antiviral agent, was investigated in female BALB/c mice. Animals were given a single intravenous dose of [H-3]-c(3)Nep (0.1 mg/kg: 10 mu Ci), and blood and selected tissues were collected at various intervals thereafter for up to 72 h. The plasma concentration versus time data for c(3)Nep was best approximated by a two-compartment open model with first order elimination. The elimination half-life was 12.8 min, the area-under curve (AUG) was 3.38 mu g.min.ml(-1). The distribution of c(3)Nep into tissues was not extensive. Following 30, 120 min,and 24 h after dosing, the kidneys and the liver contained the highest amount of drug, but this amount did not exceed 1 mu g/g tissue. At these time periods, the majority of activity in the tissues represented labeled derivatives of c(3)Nep indicating that this compound was converted to stable metabolites. The presence of labeled conversion products in the blood confirmed that this drug is metabolized in vivo. The fact that c(3)Nep bound to plasma proteins in vitro may explain this drug's limited tissue distribution. The half-life anti tissue distribution of c(3)Nep were different from those of carbocyclic 3-deazaadenosine, a related adenosine nucleoside antiviral drug and AdoHcy hydrolase inhibitor. C1 UTAH STATE UNIV,DEPT VET SCI,PROGRAM MOLEC BIOL,LOGAN,UT 84322. USA,MED RES INST INFECT DIS,FREDERICK,MD. RP COULOMBE, RA (reprint author), UTAH STATE UNIV,DEPT VET SCI,TOXICOL PROGRAM,LOGAN,UT 84322, USA. RI Coulombe, Roger/G-7523-2012 NR 13 TC 20 Z9 20 U1 0 U2 3 PU MEDECINE ET HYGIENE PI CHENE BOURG PA 46, CHEMIN DE LA MOUSSE, CHENE BOURG, SWITZERLAND SN 0378-7966 J9 EUR J DRUG METAB PH JI Eur. J. Drug Metabol. Pharmacokinet. PD JUL-SEP PY 1995 VL 20 IS 3 BP 197 EP 202 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA TF880 UT WOS:A1995TF88000006 PM 8751041 ER PT J AU RENAUD, ML CARPENTER, JA WILLIAMS, JA MANZELLATIRPAK, SA AF RENAUD, ML CARPENTER, JA WILLIAMS, JA MANZELLATIRPAK, SA TI ACTIVITIES OF JUVENILE GREEN TURTLES, CHELONIA-MYDAS, AT A JETTIED PASS IN SOUTH TEXAS SO FISHERY BULLETIN LA English DT Note ID SEA TURTLES C1 USA,CORPS ENGINEERS,GALVESTON,TX 77553. RP RENAUD, ML (reprint author), NOAA,NATL MARINE FISHERIES SERV,SE FISHERIES SCI CTR,GALVESTON LAB,4700 AVE U,GALVESTON,TX 77551, USA. NR 31 TC 25 Z9 26 U1 1 U2 6 PU NATL MARINE FISHERIES SERVICE SCIENTIFIC PUBL OFFICE PI SEATTLE PA 7600 SAND POINT WAY NE BIN C15700, SEATTLE, WA 98115 SN 0090-0656 J9 FISH B-NOAA JI Fish. Bull. PD JUL PY 1995 VL 93 IS 3 BP 586 EP 593 PG 8 WC Fisheries SC Fisheries GA RG190 UT WOS:A1995RG19000015 ER PT J AU WINN, RD ROBERTS, HH KOHL, B FILLON, RH BOUMA, AH CONSTANS, RE AF WINN, RD ROBERTS, HH KOHL, B FILLON, RH BOUMA, AH CONSTANS, RE TI LATEST QUATERNARY DEPOSITION ON THE OUTER SHELF, NORTHERN GULF-OF-MEXICO - FACIES AND SEQUENCE STRATIGRAPHY FROM MAIN-PASS BLOCK-303 SHALLOW CORE SO GEOLOGICAL SOCIETY OF AMERICA BULLETIN LA English DT Article ID U-TH AGES; SEA-LEVEL; CONTINENTAL-SHELF; OXYGEN ISOTOPES; DEEP-SEA; SEISMIC STRATIGRAPHY; OF-MEXICO; DELTA; BARBADOS; RECORD AB Sedimentologic, biostratigraphic, and isotopic geochemical data from a nearly continuous 91.4 m core and high-resolution seismic-reflection data from the middle to outer shelf east of the Mississippi River delta document deposition during changes in latest Quaternary sea levels. The data suggest that the shelf edge of the northern Gulf of Mexico is constructed from deltas deposited during falling sea level and low-stands, from sediment deposited in valleys during rising sea level, and from highstand clay. The Main Pass Block 303 core records sedimentation from the late middle Pleistocene (before ca. 135 ka) to the present. A lower delta-front interval was sampled at the core base (78.5-91.4 m). Delta sediment is truncated by a sequence boundary probably eroded during maximum glaciation corresponding to oxygen isotope stage 6 (late Illinoian?) and then modified during the following transgression. Above the sequence boundary is a transgressive shelf sand (77.2-78.5 m), overlain by burrowed, hemipelagic clay (similar to 63.4-77.2 m). The sand and clay were deposited during postglacial sea-level rise and a highstand. The rise and highstand correspond to oxygen isotope stage 5 and Ericson zone X and part of Ericson zone Y (Sangamonian-''Eowisconsinan''). The clay interval from similar to 51.8 to 63.4 m depth, in turn, was likely deposited during oxygen isotope stages 3 and 4 during the early and middle Wisconsinan. Overlying, with a transitional contact, is a relatively thick mud and sand (16 to similar to 51.8 m) deposited during the subsequent sea-level fall to the maximum late Wisconsinan lowstand (oxygen isotope stage 2). The mud and sand interval correspond to steeply dipping clinoforms on seismic-reflection records. An interpreted sequence boundary, formed during fluvial incision of the shelf during the maximum late Wisconsinan lowstand, separates deltaic sediment from overlying fluvial, bay, and marsh deposits, which fill an incised valley. Thin, regressive delta and shelf facies overlie the valley fill. Sediment above the sequence boundary (above 16 m) was deposited during the rise in sea level from the maximum late Wisconsinan lowstand to the present. Late Wisconsinan deltaic acid overlying incised-valley-fill sediment was derived from an ancestral river system that drained the southeastern United States. C1 MARATHON OIL CO,LITTLETON,CO 80160. LOUISIANA STATE UNIV,INST COASTAL STUDIES,DEPT OCEANOG & COASTAL SCI,BATON ROUGE,LA 70803. USA,NEW ORLEANS,LA 70112. TEXACO USA INC,NEW ORLEANS,LA 70160. LOUISIANA STATE UNIV,SCH GEOSCI,BATON ROUGE,LA 70803. CHEVRON USA INC,NEW ORLEANS,LA 70112. NR 68 TC 12 Z9 12 U1 0 U2 0 PU GEOLOGICAL SOC AMERICA PI BOULDER PA PO BOX 9140 3300 PENROSE PLACE, BOULDER, CO 80301 SN 0016-7606 J9 GEOL SOC AM BULL JI Geol. Soc. Am. Bull. PD JUL PY 1995 VL 107 IS 7 BP 851 EP 866 DI 10.1130/0016-7606(1995)107<0851:LQDOTO>2.3.CO;2 PG 16 WC Geosciences, Multidisciplinary SC Geology GA RG181 UT WOS:A1995RG18100007 ER PT J AU BUTLER, DK AF BUTLER, DK TI GENERALIZED GRAVITY GRADIENT ANALYSIS FOR 2-D INVERSION SO GEOPHYSICS LA English DT Article AB Gravity gradient profiles across subsurface structures that are approximately 2-D contain diagnostic information regarding depth, size, and structure (geometry). Gradient space plots, i.e., plots of horizontal gradient versus vertical gradient, present the complete magnitude and phase information in the gradient profiles simultaneously. Considerable previous work demonstrates the possibility for complete structural interpretation of a truncated plate model from the gradient space plot. The qualitative and quantitative diagnostic information contained in gradient space plots is general, however. Examination of the characteristics of gradient space plots reveals that 2-D structures are readily classified as extended or localized. For example, the truncated plate model is an extended model, while the faulted plate model is a localized model. Comparison of measured or calculated gradient space plots to a model gradient space plot catalog allows a rapid, qualitative determination of structure or geometry. ''Corners'' of a polygonal cross-section model are then determined as profile points corresponding to maxima on the vertical gradient profile. A generalized approach to structural interpretation from gravity data consists of (1) determining vertical and horizontal gradient profiles perpendicular to the strike of a 2-D gravity anomaly, (2) determining the structural geometry from the gradient space plot, and (3) locating profile positions of structural corners from the vertical gradient profile. This generalized inversion procedure requires no quantitative information or assumption regarding density contrasts. Iterative forward modeling then predicts the density contrasts. Application of this generalized gravity gradient inversion procedure to high quality gravity data results in an effective density prediction consistent with measured near-surface densities and the known increase in density with depth in deep sedimentary basins. RP BUTLER, DK (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 29 TC 14 Z9 20 U1 0 U2 7 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD JUL-AUG PY 1995 VL 60 IS 4 BP 1018 EP 1028 DI 10.1190/1.1443830 PG 11 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA RH460 UT WOS:A1995RH46000008 ER PT J AU AZIZ, A LUNARDINI, VJ AF AZIZ, A LUNARDINI, VJ TI MULTIDIMENSIONAL STEADY CONDUCTION IN CONVECTING, RADIATING, AND CONVECTING-RADIATING FINS AND FIN ASSEMBLIES SO HEAT TRANSFER ENGINEERING LA English DT Article ID 2-DIMENSIONAL RECTANGULAR FIN; HEAT-TRANSFER; ROOT TEMPERATURE; PERFORMANCE; SURFACES; PROFILE AB This article reviews the literature on multidimensional heat conduction in single fins and fin assemblies. The surface heat dissipation mechanisms include pure convection pure radiation, and simultaneous convection and radiation. Two-dimensional heat transfer results are presented for longitudinal, radial, and cylindrical fins. The discussion also covers square and polygonal fins on round tubes and composite fins. These heat transfer results encompass a variety of situations, such as a nonconstant base temperature, nonuniform ambient temperature, asymmetric thermal boundary conditions, anisotropy of fin material, variable heat transfer coefficient, and internal heat generation. The article provides a comprehensive collection of important analytical and numerical results for two-dimensional effects in extended surfaces, and, as such, both scientific and practice-oriented heat transfer workers would find the information convenient to use for analysis and design. C1 USA,COLD REG RES & ENGN LAB,APPL RES BRANCH,HANOVER,NH 03755. RP AZIZ, A (reprint author), GONZAGA UNIV,DEPT ENGN MECH,SPOKANE,WA 99258, USA. NR 61 TC 18 Z9 19 U1 0 U2 2 PU HEMISPHERE PUBL CORP PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0145-7632 J9 HEAT TRANSFER ENG JI Heat Transf. Eng. PD JUL-SEP PY 1995 VL 16 IS 3 BP 32 EP 64 DI 10.1080/01457639508939857 PG 33 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA TE112 UT WOS:A1995TE11200005 ER PT J AU ARROYO, CM VONTERSCH, RL BROOMFIELD, CA AF ARROYO, CM VONTERSCH, RL BROOMFIELD, CA TI ACTIVATION OF ALPHA-HUMAN TUMOR-NECROSIS-FACTOR (TNF-ALPHA) BY HUMAN MONOCYTES (THP-1) EXPOSED TO 2-CHLOROETHYL ETHYL SULFIDE (H-MG) SO HUMAN & EXPERIMENTAL TOXICOLOGY LA English DT Article DE TNF-ALPHA; HUMAN MONOCYTE; THP-1; ELISA; EPR SPIN TRAPPING; MNP; PROTEIN DEGRADATION; HALF-MUSTARD GAS; VESICANT AGENT ID ELECTRON-SPIN-RESONANCE; SULFUR MUSTARD; FREE-RADICALS; 2-METHYL-2-NITROSOPROPANE; LYMPHOTOXIN; NEUTROPHILS; CACHECTIN; PROTEASE; INVIVO; CELLS AB Tumour necrosis factor (TNF) is a monokine produced by monocytes and macrophages in response to different stimuli. To determine whether vesicant agents such as half-mustard gas (H-MG; chemical structure: ClCH2CH2SCH2CH3) may induce the release of TNF-alpha in human monocytes (THP-1), ELISA experiments were conducted at different post exposure times. The results indicate that: (1) Significant increases in the TNF-alpha (pg mL(-1)) concentration were observed as a function of time when THP-1 cells were exposed to 100 mu L of 2 M H-MG. A specific serine-type protease inhibitor, N-alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK), led to partial but significant inhibition of TNF activation. (2) Furthermore, this laboratory detected the generation of spin adducts of 2-methyl-2-nitrosopropane (MNP) having a resemblance to MNP-adducts generated from hydrogen atom abstraction of protein constituents.' The EPR/Spin Trapping data indicate the trapping of by-products of protein degradation after exposure to H-MG. TNF-alpha may play a role as a biochemical marker for pathophysiological changes induced by HMG or related agents. RP ARROYO, CM (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 23 TC 18 Z9 18 U1 0 U2 1 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HANTS, ENGLAND RG21 2XS SN 0144-5952 J9 HUM EXP TOXICOL JI Hum. Exp. Toxicol. PD JUL PY 1995 VL 14 IS 7 BP 547 EP 553 PG 7 WC Toxicology SC Toxicology GA RJ562 UT WOS:A1995RJ56200001 PM 7576814 ER PT J AU SHIEH, LS ZOU, X COLEMAN, NP AF SHIEH, LS ZOU, X COLEMAN, NP TI DIGITAL INTERVAL MODEL CONVERSION AND SIMULATION OF CONTINUOUS-TIME UNCERTAIN SYSTEMS SO IEE PROCEEDINGS-CONTROL THEORY AND APPLICATIONS LA English DT Article DE DIGITAL SIMULATION; GEOMETRIC-SERIES APPROXIMATION; INTERVAL MODELING; UNCERTAIN SYSTEMS AB The paper deals with the problem of converting a continuous-time uncertain linear to an equivalent discrete-time uncertain and its digital simulation. The system matrices characterising the state-space representation of the original uncertain system are assumed to be interval matrices. The geometric series method together with interval arithmetic is employed to obtain the approximate discrete-time interval models. A new technique is developed to estimate the modelling errors. These modelling errors are used to modify the approximate interval models obtained via the interval geometric-series method. The resulting interval models (the enclosing interval models) are able to tightly enclose the exact uncertain model. Also their approximate discrete-time interval solutins are able to tightly enclose the exact interval solution of the continuous-time uncertain state-space equation. The proposed digital uncertain models can be used for digital simulation and digital design of continuous-time uncertain systems. C1 USA,CTR ARMAMENT,DOVER,NJ 07806. RP SHIEH, LS (reprint author), UNIV HOUSTON,DEPT ELECT & COMP ENGN,HOUSTON,TX 77204, USA. NR 16 TC 9 Z9 9 U1 1 U2 1 PU IEE-INST ELEC ENG PI HERTS PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTS, ENGLAND SG1 2AY SN 1350-2379 J9 IEE P-CONTR THEOR AP JI IEE Proc.-Control Theory Appl. PD JUL PY 1995 VL 142 IS 4 BP 315 EP 322 DI 10.1049/ip-cta:19951878 PG 8 WC Automation & Control Systems; Engineering, Electrical & Electronic; Instruments & Instrumentation SC Automation & Control Systems; Engineering; Instruments & Instrumentation GA RP227 UT WOS:A1995RP22700008 ER PT J AU TWYFORD, EJ JOKERST, NM KOHL, PA TAYAG, TJ AF TWYFORD, EJ JOKERST, NM KOHL, PA TAYAG, TJ TI A PIXELLATED GRATING ARRAY USING PHOTOELECTROCHEMICAL ETCHING ON A GAAS WAVE-GUIDE SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article ID FABRICATION AB We have demonstrated and evaluated a grating array outcoupler fabricated by photoelectrochemical (PEC) etching, a manufacturable and practical approach for fabrication of grating-based II-V semiconductor waveguide devices, An array of submicron period gratings was etched into photolithographically delineated areas in a single PEC step, The fabricated devices are: 10-mu m wide rib waveguides with 0.35-mu m first-order outcoupling gratings; and 10-mu m wide rib waveguides with 10 mu m x 10 mu m pixellated areas of gratings, Device characterization demonstrates the effectiveness of outcoupling grating fabrication using PEC and that the pixellated grating outcoupler is an effective and simple means of generating an optical beam array. C1 USA,RES LAB,ADELPHI,MD 20783. RP TWYFORD, EJ (reprint author), GEORGIA INST TECHNOL,SCH ELECT & COMP ENGN,MICROELECTR RES CTR,ATLANTA,GA 30332, USA. NR 12 TC 0 Z9 0 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD JUL PY 1995 VL 7 IS 7 BP 766 EP 768 DI 10.1109/68.393199 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA RH308 UT WOS:A1995RH30800024 ER PT J AU HANSEN, RC LIBELO, LF AF HANSEN, RC LIBELO, LF TI WIDE-BAND DISPERSION IN BASEBAND SYSTEMS SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID PULSE-DRIVEN ARRAYS; ANTENNA AB To avoid dispersion caused by an explicit lambda(2) in either the one-way, or two-way range equations, the antenna gain product must be proportional to frequency squared For the one-way case this is equivalent to one antenna with gain independent of frequency, and the other antenna with effective area independent of frequency. Both gain and effective area must include impedance mismatch effects. Antennas in general are examined to determine gain and effective area variation over a wide frequency band The effects on representative short pulse waveform of system with a gain product constant with frequency, and of systems with an effective area product constant with frequency are explored. C1 USA,RES LABS,ADELPHI,MD 20783. RP HANSEN, RC (reprint author), RC HANSEN INC,POB 570215,TARZANA,CA 91357, USA. NR 28 TC 2 Z9 2 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9251 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD JUL PY 1995 VL 31 IS 3 BP 881 EP 890 DI 10.1109/7.395250 PG 10 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA RJ728 UT WOS:A1995RJ72800002 ER PT J AU SADLER, BM GIANNAKIS, GB SHAMSUNDER, S AF SADLER, BM GIANNAKIS, GB SHAMSUNDER, S TI NOISE SUBSPACE TECHNIQUES IN NON-GAUSSIAN NOISE USING CUMULANTS SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID MULTIPLE AB We consider noise subspace methods for narrowband direetion-of-arrival or harmonic retrieval in colored linear non-Gaussian noise of unknown covariance and unknown distribution The non-Gaussian noise covariance is estimated via higher order cumulants and combined with correlation information to solve a generalized eigenvalue problem The estimated eigenvectors are used in a variety of noise subspace methods such as multiple signal classification (MUSIC), MVDR, and eigenvector. The noise covariance estimates are obtained in the presence of the harmonic signals, obviating the need for noise-only training records. The covariance estimates may be obtained nonparametrically via cumulant projections, or parametrically using autoregressive moving average (ARMA) models. An information theoretic criterion using higher order cumulants is presented which may be used to simultaneously estimate the ARMA model order and parameters. Third and fourth-order cumulants are employed for asymmetric and symmetric probability density function (pdf) cases, respectively. Simulation results show considerable improvement over conventional methods,vith no prewhitening. The effects of prewhitening are particularly evident in the dominant eigenvalues, as revealed by singular value decomposition (SVD) analysis. C1 UNIV VIRGINIA,DEPT ELECT ENGN,CHARLOTTESVILLE,VA 22903. COLORADO STATE UNIV,DEPT ELECT ENGN,FT COLLINS,CO 80523. RP SADLER, BM (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 28 TC 21 Z9 22 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9251 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD JUL PY 1995 VL 31 IS 3 BP 1009 EP 1018 DI 10.1109/7.395239 PG 10 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA RJ728 UT WOS:A1995RJ72800013 ER PT J AU WALLS, FL VIG, JR AF WALLS, FL VIG, JR TI FUNDAMENTAL LIMITS ON THE FREQUENCY STABILITIES OF CRYSTAL-OSCILLATORS SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID QUARTZ OSCILLATORS; VACUUM CHAMBER AB The frequency instabilities of precision bulk acoustic wave (BAW) quartz crystal oscillators are reviewed, The fundamental limits on the achievable frequency stabilities, and the degree to which the fundamental limits have been approached to date are examined, Included are the instabilities as a function of time, temperature, acceleration, ionizing radiation, electromagnetic fields, humidity, atmospheric pressure, power supply, and load impedance. Most of the fundamental limits are zero or negligibly small, a few are finite, We speculate about the progress which may be achievable in the future with respect to approaching the fundamental limits, Suggestions are provided about the paths that may lead to significant stability improvements. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP WALLS, FL (reprint author), NATL INST STAND & TECHNOL,BOULDER,CO 80303, USA. OI Vig, John/0000-0002-2378-0113 NR 107 TC 64 Z9 66 U1 1 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD JUL PY 1995 VL 42 IS 4 BP 576 EP 589 DI 10.1109/58.393101 PG 14 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA RJ074 UT WOS:A1995RJ07400012 ER PT J AU VIG, JR FILLER, RL AF VIG, JR FILLER, RL TI TEMPERATURE STABLE CRYSTAL-OSCILLATOR SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Letter AB A crystal oscillator is proposed which can exhibit a frequency versus temperature stability comparable to that of the best atomic frequency standards. RP VIG, JR (reprint author), USA,RES LAB,FREQUENCY CONTROL & TIMING BRANCH,AMSRL PS ED,FT MONMOUTH,NJ 07703, USA. OI Vig, John/0000-0002-2378-0113 NR 14 TC 7 Z9 7 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD JUL PY 1995 VL 42 IS 4 BP 797 EP 799 DI 10.1109/58.393126 PG 3 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA RJ074 UT WOS:A1995RJ07400036 ER PT J AU GLENN, GM RAO, M RICHARDS, RL MATYAS, GR ALVING, CR AF GLENN, GM RAO, M RICHARDS, RL MATYAS, GR ALVING, CR TI MURINE IGG SUBCLASS ANTIBODIES TO ANTIGENS INCORPORATED IN LIPOSOMES CONTAINING LIPID-A SO IMMUNOLOGY LETTERS LA English DT Article DE IGG SUBCLASS RESPONSE; LIPID A; SPF66; CHOLERA TOXIN; BALB/C MOUSE ID CHOLERA-TOXIN; IMMUNOLOGICAL ADJUVANTS; ISOTYPE; LIPOPOLYSACCHARIDE; DIFFERENTIATION AB The IgG subclass responses to antigens incorporated in liposomes containing lipid A were investigated using a synthetic malarial antigen (SPf66) and cholera toxin (CT). The antigen-specific IgG subclass response was determined in BALB/c mice immunized with either: (a) SPf66 encapsulated in liposomes containing lipid A, (b) CVT bound to the surface of liposomes containing lipid A, or (c) both encapsulated SPf65 and surface-bound CT in the same liposomes. In each case the antibodies to SPf66, CT and lipid A demonstrated an IgG2a predominance. Liposomes containing lipid A not only increased the magnitude of the antibody response to liposomal antigens but elicited predominantly IgG2a subclass antibodies as well. RP GLENN, GM (reprint author), WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307, USA. NR 17 TC 17 Z9 17 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2478 J9 IMMUNOL LETT JI Immunol. Lett. PD JUL-AUG PY 1995 VL 47 IS 1-2 BP 73 EP 78 DI 10.1016/0165-2478(95)00069-H PG 6 WC Immunology SC Immunology GA RU972 UT WOS:A1995RU97200012 PM 8537104 ER PT J AU RAO, M WASSEF, NM ALVING, CR KRZYCH, U AF RAO, M WASSEF, NM ALVING, CR KRZYCH, U TI INTRACELLULAR PROCESSING OF LIPOSOME-ENCAPSULATED ANTIGENS BY MACROPHAGES DEPENDS UPON THE ANTIGEN SO INFECTION AND IMMUNITY LA English DT Article ID CLASS-II MHC; T-CELLS; SYNTHETIC MACROPHAGES; STRUCTURAL PROTEINS; B-CELLS; INDUCTION; MOLECULES; RESPONSES; LIPIDS; IL-1 AB Two proteins, a recombinant malaria protein (R32NS1) and conalbumin, were encapsulated in separate liposomes. The mechanisms of presentation of unencapsulated and liposome-encapsulated R32NS1 and conalbumin to antigen-specific T-cell clones were investigated in in vitro antigen presentation assays using murine bone marrow-derived macrophages (BMs) as antigen-presenting cells. A much lower concentration of liposomal antigen than of unencapsulated antigen was required for T-cell proliferation. Liposome encapsulated conalbumin required intracellular processing by BMs for antigen-specific T-cell proliferation, as determined by inhibition with chloroquine, NH4Cl, leupeptin, brefeldin A, monensin, antimycin A, NaF, and cycloheximide and by treatment of BMs with glutaraldehyde. Liposome encapsulated conalbumin therefore follows the classical intracellular antigen processing pathway described for protein antigens. Similarly, unencapsulated conalbumin also required intracellular processing for presentation to antigen-specific T cells. In contrast, both unencapsulated R32NS1 and liposome-encapsulated R32NS1 were presented to T cells by BMs without undergoing internalization and intracellular processing. These results suggest that the antigen itself is the major element that determines whether a requirement exists for intracellular processing of liposomal antigens by macrophages. C1 WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. RP RAO, M (reprint author), WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307, USA. NR 28 TC 21 Z9 22 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUL PY 1995 VL 63 IS 7 BP 2396 EP 2402 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA RE842 UT WOS:A1995RE84200002 PM 7790049 ER PT J AU CLAYTON, MA CLAYTON, JM BROWN, DR MIDDLEBROOK, JL AF CLAYTON, MA CLAYTON, JM BROWN, DR MIDDLEBROOK, JL TI PROTECTIVE VACCINATION WITH A RECOMBINANT FRAGMENT OF CLOSTRIDIUM-BOTULINUM NEUROTOXIN SEROTYPE A EXPRESSED FROM A SYNTHETIC GENE IN ESCHERICHIA-COLI SO INFECTION AND IMMUNITY LA English DT Article ID TETANUS; DNA AB A completely synthetic gene encoding fragment C, a similar to 50-kDa fragment, of botulinum neurotoxin serotype A was constructed from oligonucleotides. The gene was expressed in Escherichia coli, and full-sized product was produced as judged by Western blot (immunoblot) analysis. Crude extracts of E. coli expressing the gene were used to vaccinate mice and evaluate their survival against challenge with active toxin. Mice given three subcutaneous vaccinations were protected against an intraperitoneal administration of 10(6) 50% lethal doses (LD(50)) of serotype A toxin. The same mice survived when challenged with 3 LD(50) of botulinum toxin serotype E but died when challenged with 10 LD(50) of serotype E or 3 LD(50) of serotype B. Purified fragment C was compared with the botulinum toroid vaccine in a vaccination and challenge study. Fragment C was as efficacious in protecting against challenge with active botulinum neurotoxin serotype A as the toroid vaccine. This recombinant protein product has many properties that make it a good candidate for human use to protect against botulinum toxin. C1 USA,MED RES INST INFECT DIS,DIV TOXINOL,FREDERICK,MD 21702. NR 20 TC 120 Z9 124 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUL PY 1995 VL 63 IS 7 BP 2738 EP 2742 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA RE842 UT WOS:A1995RE84200048 PM 7790092 ER PT J AU LEVENSON, VJ MALLETT, CP HALE, TL AF LEVENSON, VJ MALLETT, CP HALE, TL TI PROTECTION AGAINST LOCAL SHIGELLA-SONNEI INFECTION IN MICE BY PARENTERAL IMMUNIZATION WITH A NUCLEOPROTEIN SUBCELLULAR VACCINE SO INFECTION AND IMMUNITY LA English DT Note ID RIBOSOMAL VACCINES; OLIGODEOXYRIBONUCLEOTIDES; LIPOPOLYSACCHARIDE; POLYSACCHARIDE; ANTIBODIES; SALMONELLA; CELLS; MOUSE AB Nucleoprotein subcellular (NPS) vaccine, consisting of ribosome-bound O polysaccharide, was prepared from avirulent Shigella sonnei. NPS vaccine was tested for safety and protective activity in the mouse intranasal challenge model of Shigella infection. The vaccine was nontoxic when injected in doses up to 10,000 mu g, and a single subcutaneous injection of as little as 0.1 mu g gave significant protection against a lethal intranasal challenge with S. sonnei. These data demonstrate the induction of local protective immunity by parenteral immunization, support the concept of the ribosome as a potent vaccine vector, and give additional evidence for the protective activity of the NPS vaccine against Shigella infection. RP LEVENSON, VJ (reprint author), WALTER REED ARMY INST RES,DEPT ENTER INFECT,14TH & DAHLIA ST NW,WASHINGTON,DC 20307, USA. NR 49 TC 11 Z9 12 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUL PY 1995 VL 63 IS 7 BP 2762 EP 2765 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA RE842 UT WOS:A1995RE84200051 PM 7790095 ER PT J AU MITASOVA, H MITAS, L BROWN, WM GERDES, DP KOSINOVSKY, I BAKER, T AF MITASOVA, H MITAS, L BROWN, WM GERDES, DP KOSINOVSKY, I BAKER, T TI MODELING SPATIALLY AND TEMPORALLY DISTRIBUTED PHENOMENA - NEW METHODS AND TOOLS FOR GRASS GIS SO INTERNATIONAL JOURNAL OF GEOGRAPHICAL INFORMATION SYSTEMS LA English DT Article; Proceedings Paper CT 2nd International Conference/Workshop on Integrating GIS and Environmental Modelling CY SEP, 1993 CL BRECKENRIDGE, CO ID SOIL LOSS EQUATION; REGULARIZED SPLINE; INTERPOLATION; TENSION AB The concept of GRASS (Geographic Resources Analysis Support System) as an open system has created a favourable environment for integration of process based modelling and GIS. To support this integration a new generation of tools is being developed in the following areas: (a) interpolation from multidimensional scattered point data, (b) analysis of surfaces and hypersurfaces, (c) modelling of spatial processes and, (d) 3D dynamic visualization. Examples of two applications are given - spatial and temporal modelling of erosion and deposition, and multivariate interpolation and visualization of nitrogen concentrations in the Chesapeake Bay. C1 UNIV ILLINOIS,DEPT GEOG,URBANA,IL 61801. RP MITASOVA, H (reprint author), USA,CONSTRUCT ENGN RES LABS,POB 9005,CHAMPAIGN,IL 61826, USA. RI Namikawa, Laercio/C-5559-2013; Hofierka, Jaroslav/P-4207-2016; OI Namikawa, Laercio/0000-0001-7847-1804; Hofierka, Jaroslav/0000-0002-7691-8518; Mitasova, Helena/0000-0002-6906-3398 NR 32 TC 62 Z9 65 U1 1 U2 9 PU TAYLOR & FRANCIS LTD LONDON PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0269-3798 J9 INT J GEOGR INF SYST JI Int. J. Georg. Inf. Syst. PD JUL-AUG PY 1995 VL 9 IS 4 BP 433 EP 446 DI 10.1080/02693799508902048 PG 14 WC Geography; Information Science & Library Science SC Geography; Information Science & Library Science GA RQ493 UT WOS:A1995RQ49300007 ER PT J AU KOTULAK, JC MORSE, SE RABIN, JC AF KOTULAK, JC MORSE, SE RABIN, JC TI OPTICAL COMPENSATION FOR NIGHT MYOPIA BASED ON DARK FOCUS AND CA/C RATIO SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Article DE ACCOMMODATION; CA/C RATIO; DARK FOCUS; NIGHT MYOPIA; OPTICAL CORRECTION ID TONIC ACCOMMODATION; CONVERGENCE ACCOMMODATION; RESTING FOCUS; ADAPTATION; LUMINANCE; VERGENCE; CONTRAST; DESIGN; LASER AB Purpose. To determine whether individual differences in dark focus and convergence accommodation to convergence (CA/C) ratio can be used to prescribe the best optical correction for night myopia. Methods. The best correction for night myopia was obtained by measuring visual acuity and contrast sensitivity across a range of lens powers and luminances. Dark focus was measured with an infrared optometer, and CA/C ratio was measured with an infrared optometer and eyetracker. Only young subjects were used (mean age = 25.4 years). Results. Optimal lens power was significantly correlated with dark focus, regardless of CA/C ratio. However, the slope of the regression line relating lens power to dark focus was steeper for subjects with CA/C ratios less than 0.4 diopters/meter angle (D/MA, n = 7) than for subjects with CA/C ratios greater than 0.4 D/MA (n = 9). The mean CA/C ratio for the entire sample (n = 16) was 0.59 D/MAL. The mean optimal lens power and dark focus were -0.79 and 0.74 D, respectively, for the low CA/C group, and -0.60 and 0.91 D, respectively, for the high CA/C group. Conclusions. Visual performance in night myopia can be optimized by taking into account intersubject differences in dark focus and CA/C ratio. Best visual performance was found with a lens roughly equaling the full dark focus for subjects with low CA/C ratios and half the dark focus for subjects with high CA/C ratios. C1 USA,EVANS COMMUNITY HOSP,FT CARSON,CO. RP KOTULAK, JC (reprint author), USA,AEROMED RES LAB,POB 620577,FT RUCKER,AL 36360, USA. NR 52 TC 8 Z9 8 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD JUL PY 1995 VL 36 IS 8 BP 1573 EP 1580 PG 8 WC Ophthalmology SC Ophthalmology GA RG990 UT WOS:A1995RG99000010 PM 7601638 ER PT J AU BOITNOTT, RL STARNES, JH JOHNSON, ER AF BOITNOTT, RL STARNES, JH JOHNSON, ER TI NONLINEAR RESPONSE AND FAILURE OF PRESSURIZED COMPOSITE CURVED PANELS SO JOURNAL OF AEROSPACE ENGINEERING LA English DT Article AB Results of an experimental and analytical study of the nonlinear response and failure characteristics of internally pressurized 4- to 16-ply-thick graphite-epoxy cylindrical panels are presented. Specimens were clamped in a test fixture to simulate the skin between two frames and two stringers of a typical transport fuselage and tested to failure, Aluminum specimens were also tested to failure and the results of these tests are compared with the graphite-epoxy test results. The graphite-epoxy specimens failed at their edges where the magnitudes of severe local bending gradients and interlaminar stresses are maximum. A shell analysis using the STAGS computer code showed that the response is independent of the axial coordinate outside of the bending boundary layers at the curved ends. A nonlinear, one-dimensional analysis in the circumferential coordinate is developed that includes transverse shearing deformations and computes interlaminar stresses. Accurate panel radius measurements and measurements of edge circumferential displacements associated with specimen slipping were required in the one-dimensional analysis to obtain good correlation between analytical and experimental results. Results indicate that all panels tested, including the thin four-ply panels, can support supplied internal pressures that are well above the proof pressure loading expected for transport fuselage structures. C1 NASA,LANGLEY RES CTR,DIV STRUCT,STRUCT MECH BRANCH,HAMPTON,VA 23665. VIRGINIA POLYTECH INST & STATE UNIV,DEPT AEROSP & OCEAN ENGN,BLACKSBURG,VA 24061. RP BOITNOTT, RL (reprint author), USA,RES LAB,LANGLEY RES CTR,VEHICLE STRUCT DIRECTORATE,HAMPTON,VA 23681, USA. NR 15 TC 2 Z9 2 U1 2 U2 4 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0893-1321 J9 J AEROSPACE ENG JI J. Aerosp. Eng. PD JUL PY 1995 VL 8 IS 3 BP 129 EP 138 DI 10.1061/(ASCE)0893-1321(1995)8:3(129) PG 10 WC Engineering, Aerospace; Engineering, Civil SC Engineering GA RZ835 UT WOS:A1995RZ83500001 ER PT J AU Despins, JL Hunter, JS Davey, RB George, JE AF Despins, JL Hunter, JS Davey, RB George, JE TI Microencapsulated permethrin sprays for control of southern cattle tick, Boophilus microplus (Canestrini) (Acari:Ixodidae), infesting Holstein dairy heifers on Saint Croix, US Virgin Islands SO JOURNAL OF AGRICULTURE OF THE UNIVERSITY OF PUERTO RICO LA English DT Article DE southern cattle tick; Boophilus microplus; dairy heifers; permethrin ID LIVESTOCK AB The effectiveness of two acaricides was evaluated for control of populations of the southern cattle tick, Boophilus microplus on dairy cattle in St. Croix, U.S. Virgin Islands. Two different concentrations of a microencapsulated (ME) formulation of permethrin (0.05% and 0.10% al) and one concentration of coumaphos emulsifiable concentrate (EC) (0.117% al) were sprayed on Holstein heifers that had a natural infestation of ticks. The length of residual activity of EC coumaphos and ME permethrin at 0.05% (al) was at least four days, and for ME permethrin at 0.10% al at least seven days. There was no apparent increase in the residual activity period of ME permethrin in comparison to that in field trials of other formulations of permethrin against B. microplus. Percentage control for the three treatment groups from days 4 through 21 was ME permethrin (0.05% al) 96%; ME permethrin (0.10% al), 97%; coumaphos, 98.3%. There were no significant differences among the treatment groups (F = 2.21, df = 2, 17, P > 0.10). This research confirms the usefulness of permethrin as an alternative to coumaphos for control of B. microplus populations on cattle. RP Despins, JL (reprint author), USA,ENVIRONM HYG AGCY,ESD,ATTN HSHB MR E,BLDG E-5800,ABERDEEN PROVING GROUND,MD 21010, USA. NR 15 TC 2 Z9 2 U1 1 U2 1 PU PUERTO RICO AGR EXP STA PI RIO PIEDRAS PA PUBLICATIONS SECTION VENEZUELA BRANCH, RIO PIEDRAS, PR 00927 SN 0041-994X J9 J AGR U PUERTO RICO JI J. Agric. Univ. P. R. PD JUL-OCT PY 1995 VL 79 IS 3-4 BP 93 EP 98 PG 6 WC Agriculture, Multidisciplinary SC Agriculture GA TX470 UT WOS:A1995TX47000001 ER PT J AU STRAWN, RC BISWAS, R GARCEAU, M AF STRAWN, RC BISWAS, R GARCEAU, M TI UNSTRUCTURED ADAPTIVE MESH COMPUTATIONS OF ROTORCRAFT HIGH-SPEED IMPULSIVE NOISE SO JOURNAL OF AIRCRAFT LA English DT Article AB A new method is developed for modeling helicopter high-speed impulsive (HSI) noise. The aerodynamics and acoustics near the rotor blade tip are computed by solving the Euler equations on an unstructured grid, A stationary Kirchhoff surface integral is then used to propagate these acoustic signals to the far field, The near-field Euler solver uses a solution-adaptive grid scheme to improve the resolution of the acoustic signal, Grid points are locally added and/or deleted from the mesh at each adaptive step, An important part of this procedure is the choice of an appropriate error indicator, The error indicator is computed from the flowfield solution and determines the regions for mesh coarsening and refinement, Computed results for HSI noise compare favorably with experimental data for three different hovering rotor cases. RP STRAWN, RC (reprint author), NASA,AMES RES CTR,USA,AVIAT & TROOP COMMAND,AEROFLIGHTDYNAM DIRECTORATE,M-S 258-1,MOFFETT FIELD,CA 94035, USA. NR 0 TC 12 Z9 12 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD JUL-AUG PY 1995 VL 32 IS 4 BP 754 EP 760 DI 10.2514/3.46787 PG 7 WC Engineering, Aerospace SC Engineering GA RP012 UT WOS:A1995RP01200010 ER PT J AU LECLAIRE, RD PARKER, GW FRANZ, DR AF LECLAIRE, RD PARKER, GW FRANZ, DR TI HEMODYNAMIC AND CALORIMETRIC CHANGES INDUCED BY MICROCYSTIN-LR IN THE RAT SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE MICROCYSTIN; HEMODYNAMIC; CALORIMETRIC; ACID-BASE BALANCE; RAT; HEMORRHAGIC SHOCK ID CARDIAC-OUTPUT; ULTRASTRUCTURAL-CHANGES; PROTEIN PHOSPHATASE-1; THERMODILUTION METHOD; BLOOD-PRESSURE; FASTED RATS; AERUGINOSA; BIOTRANSFORMATION; EXCRETION; LIVER AB Microcystin-LR, a cyclic peptide from the cyanobacterium Microcystis aeruginosa, given at acutely toxic doses causes severe hepatic interstitial hemorrhage. Hemodynamic, calorimetric and acid-base balance changes after i.v, microcystin were measured, The effect of isoproterenol, dopamine, methylprednisolone and whole-blood volume expansion on the immediate hemodynamic effects after toxin administration were also evaluated. A dose of 100 mu g kg(-1) was invariably lethal for rats in all studies. Pathophysiological changes included: a sustained, rapid decline in cardiac output and stroke volume; an acute hypotension responsive to volume expansion with whole blood; a decreased heart rate, responsive to both isoproterenol and dopamine; an early decline in oxygen consumption, carbon dioxide production and metabolic rate accompanied by progressive hypothermia; and acid-base balance changes indicating partially compensated metabolic acidosis. The lethal effects of microcystin-LR were previously attributed to hypovolemic shock as a result of hepatic interstitial hemorrhage. These results indicate that, in addition, there may be a cardiogenic component that limits the physiological cardiac reserve, compromising a normal response to circulatory inadequacy. RP LECLAIRE, RD (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702, USA. NR 29 TC 9 Z9 10 U1 0 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD JUL-AUG PY 1995 VL 15 IS 4 BP 303 EP 311 DI 10.1002/jat.2550150412 PG 9 WC Toxicology SC Toxicology GA RM131 UT WOS:A1995RM13100010 PM 7594200 ER PT J AU NETHERLAND, MD GETSINGER, KD AF NETHERLAND, MD GETSINGER, KD TI LABORATORY EVALUATION OF THRESHOLD FLURIDONE CONCENTRATIONS UNDER STATIC CONDITIONS FOR CONTROLLING HYDRILLA AND EURASIAN WATERMILFOIL SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE HYDRILLA VERTICILLATA; MYRIOPHYLLUM SPICATUM; DOSE-RESPONSE AQUATIC HERBICIDE AB Fluridone {1-methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone} was evaluated against Eurasian watermilfoil (Myriophyllum spicatum L.) and hydrilla (Hydrilla verticillate (L.f.) Royle) under laboratory conditions at initial treatment rates of 0.0, 0.25, 0.5, 0.75, 1.0, 2.0, 3.0, 4.0, and 25.0 mu g/L for 90 days of exposure. Treatment concentrations < 1 mu g/L had no effect on either hydrilla or Eurasian water-milfoil biomass and resulted in only a small reduction (13 to 33%) in hydrilla net photosynthesis (PTS) and chlorophyll at 0.75 mu g/L. Both hydrilla and Eurasian watermilfoil growth were inhibited by fluridone concentrations between 1.0 to 3.0 mu g/L. Rates of 1.0 and 2.0 mu g/L did not reduce hydrilla biomass below pretreatment levels, but did inhibit growth. Biomass remained static from 30 through 90 days after treatment, while chlorophyll and PTS continued to decrease. Eurasian watermilfoil biomass and physiological variables were inhibited as fluridone rates reached 3.0 mu g/L. With fluridone concentrations of 4.0, and 25.0 mu g/L, hydrilla and Eurasian watermilfoil biomass and physiological variables were reduced (42 to 88%) below pretreatment levels by 30 days after treatment. If PTS readings at shoot apices remained positive following fluridone treatment, shoot biomass increased; whereas negative PTS readings were associated with biomass decreases below pretreatment levels. In general, the appearance of treatment symptoms was delayed as treatment concentrations decreased. RP NETHERLAND, MD (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 11 TC 40 Z9 42 U1 0 U2 5 PU AQUATIC PLANT MANAGEMENT SOC, INC PI CLERMONT PA PO BOX 121086, CLERMONT, FL 34712-1086 SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 1995 VL 33 BP 33 EP 36 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA RH638 UT WOS:A1995RH63800001 ER PT J AU NETHERLAND, MD GETSINGER, KD AF NETHERLAND, MD GETSINGER, KD TI POTENTIAL CONTROL OF HYDRILLA AND EURASIAN WATERMILFOIL UNDER VARIOUS FLURIDONE HALF-LIFE SCENARIOS SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE HYDRILLA VERTICILLATA; MYRIOPHYLLUM SPICATUM; DOSE RESPONSE; HERBICIDE HALF-LIFE; RHODAMINE DYE ID DEGRADATION AB Fluridone {1-methyl-3-phenyl-5-[3-(trifluoromethyl)phenyl]-4(1H)-pyridinone} efficacy against Eurasian watermilfoil (Myriophyllum spicatum L.) and hydrilla (Hydrilla verticillata (L.f.) Royle) was evaluated by simulating herbicide degradation/dissipation half-lives (t(1/2)) under controlled-environment conditions. Fluridone treatment rates of 100 mu g/L for 7, 10, and 14 d t(1/2), 50 mu g/L for 14 and 21 d t(1/2), 25 mu g/L for a 28 d t(1/2), and static treatments of 5 and 15 mu g/L for 105 d were tested. Chlorophyll content and net photosynthesis were measured at 7, 28, 56, 77, and 105 d posttreatment, and biomass was collected at 28, 56, 77 or 84, and 105 or 108 d posttreatment to assess efficacy. The 7 and 10 d t(1/2) treatments dissipated to 0 mu g/L at 42 and 62 d respectively resulting in rapid recovery of both hydrilla and Eurasian watermilfoil. The 14 d t(1/2) resulted in exposures of 82 to 84 d, and although hydrilla biomass remained significantly reduced, physiological recovery indicated the potential for biomass recovery. Eurasian watermilfoil was completely controlled at 84 d posttreatment following both 14 d t(1/2) treatment. The 21 and 28 d t(1/2) and static treatments maintained low fluridone exposures throughout the 105 d study period. These treatments reduced hydrilla biomass significantly (>90%), and physiological variables showed no evidence of recovery at completion of the study. These treatments also resulted in near 100% control of milfoil biomass by the 84 d harvest. Results indicate that following initial injury at higher treatment levels, extremely low levels of fluridone (1 to 3 mu g/ L) prevent recovery. Herbicidal activity of these low concentrations may explain the long-term control achieved with fluridone in situations that allow long degradation half-lives (>14 d). RP NETHERLAND, MD (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 30 TC 16 Z9 17 U1 1 U2 4 PU AQUATIC PLANT MANAGEMENT SOC, INC PI CLERMONT PA PO BOX 121086, CLERMONT, FL 34712-1086 SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 1995 VL 33 BP 36 EP 42 PG 7 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA RH638 UT WOS:A1995RH63800002 ER PT J AU SPRECHER, SL STEWART, AB AF SPRECHER, SL STEWART, AB TI TRICLOPYR EFFECTS ON PEROXIDASE-ACTIVITY IN TARGET AND NONTARGET AQUATIC PLANTS SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE MYRIOPHYLLUM SPICATUM; ELODEA CANADENSIS; POTAMOGETON PECTINATUS; VALLISNERIA AMERICANA; HERBICIDE ID EURASIAN WATERMILFOIL; TOLERANCE; OXIDASE; STRESS; TISSUE AB Rapid and characteristic physiological responses to herbicidal. activity in aquatic plants have potential for monitoring treatment effect in laboratory evaluations and operational applications, or indicating contaminant runoff in aquatic ecosystems. Change in peroxidase enzyme (PRX) has been considered for use as such a parameter, and was investigated following application of the auxin-like herbicide triclopyr to four species at 1 mg ae/l for 12 hr, and 2.5 mg ae/l for 24 hr. Guaiacol-specific PRX increased rapidly within 1.5 days after triclopyr application in the dicot Eurasian watermilfoil (Myriophyllum spicatum L.). The non-target monocots elodea (Elodea canadensis Rich.), sage pondweed (Potamogeton pectinatus L.), and vallisneria (Vallisneria americana Michx.) showed no visual effects of triclopyr treatment through 8 DAT, and PRX levels were unchanged in treated and untreated plants during this time. However, by 35 DAT the 2.5 mg/l triclopyr rate (the maximum label rate) had reduced biomass of sage pondweed by 60%. The early PRX response to triclopyr effect which differentiated Eurasian watermilfoil from non-target species suggests that this parameter may be predictive of rapid susceptibility to this herbicide. C1 ASCI CORP,VICKSBURG,MS 39180. RP SPRECHER, SL (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 29 TC 7 Z9 9 U1 1 U2 2 PU AQUATIC PLANT MANAGEMENT SOC, INC PI CLERMONT PA PO BOX 121086, CLERMONT, FL 34712-1086 SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 1995 VL 33 BP 43 EP 48 PG 6 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA RH638 UT WOS:A1995RH63800003 ER PT J AU OWENS, CS MADSEN, JD AF OWENS, CS MADSEN, JD TI LOW-TEMPERATURE LIMITS OF WATER-HYACINTH SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE EICHHORNIA CRASSIPES; FROST-RESISTANCE; COLD-TOLERANCE; HARDINESS AB The range of waterhyacinth appears to be limited by cold temperatures to tropical or subtropical regions, although little experimental information exists on the cold-tolerance of the plant. Over the winters of 1992-1993 and 1993-1994, field and controlled laboratory experiments were conducted on the ability of waterhyacinth to withstand low air temperatures, Waterhyacinth withstood near-freezing temperature (<5C) for a limited period of time, but exhibited a steady decline in regrowth potential. Rooted plants appeared to resist the effects of cold temperature longer than free-floating plants. C1 USA,ENGINEER WATERWAYS EXPT STN,LEWISVILLE AQUAT ECOSYST RES FACIL,LEWISVILLE,TX 75056. RP OWENS, CS (reprint author), ASCI CORP,LEWISVILLE AQUAT ECOSYST RES FACIL,RR 3,BOX 446,LEWISVILLE,TX 75056, USA. NR 8 TC 21 Z9 23 U1 0 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI CLERMONT PA PO BOX 121086, CLERMONT, FL 34712-1086 SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 1995 VL 33 BP 63 EP 68 PG 6 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA RH638 UT WOS:A1995RH63800008 ER PT J AU YU, H BRUNO, JG CHENG, TC CALOMIRIS, JJ GOODE, MT AF YU, H BRUNO, JG CHENG, TC CALOMIRIS, JJ GOODE, MT TI A COMPARATIVE-STUDY OF PCR PRODUCT DETECTION AND QUANTITATION BY ELECTROCHEMILUMINESCENCE AND FLUORESCENCE SO JOURNAL OF BIOLUMINESCENCE AND CHEMILUMINESCENCE LA English DT Article DE ELECTROCHEMILUMINESCENCE; MAGNETIC SEPARATION; DNA PROBES; PCR; QUANTITATION ID ASSAYS; DNA AB Amplification and detection of target DNA sequences are made possible in a polymerase chain reaction (PCR) by using a mixture of biotinylated and ruthenium(II) trisbipyridal (Ru(bpy)(3)(2+))-end-labelled primers. In this way, biotin for capture and RU(bpy)(3)(2+) for detection are directly incorporated into the PCR product obviating subsequent probe hybridization. PCR of a bacterial DNA template from Alteromonas species strain JD6.5 using a cocktail of biotin- and Ru(bpy)(3)(2+)-labelled primers amplified a 1 kilobase region. Serial dilution of PCR product followed by magnetic separation with Streptavidin (SA)-coated magnetic beads and an electrochemiluminescence (ECL) assay using the semi-automated QPCR System 5000 demonstrated sensitive (pg range) DNA detection. ECL assay of probe hybridization to a human immunodeficiency virus (HIV) sequence also produced pg level sensitivity. Quantitative DNA determination by ECL assay correlated well with visual detection of DNA in electrophoretic gels. However, DNA detection by ECL assay was 10 to 100 times more sensitive than conventional ethidium bromide staining. The combination of DNA-based magnetic separation with ECL assay provides a very sensitive and rapid method of quantitating DNA which, owing to its rapid and facile nature, may have many applications in the research, environmental monitoring, industrial and clinical fields. C1 USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD RTE,USAF,ARMSTRONG LAB,CBDCOM,CREW SYST DIRECTORATE AL CFD,ABERDEEN PROVING GROUND,MD 21010. OPTECH CORP,SAN ANTONIO,TX 78229. SCI & TECHNOL CORP,EDGEWOOD,MD 21040. NR 11 TC 36 Z9 42 U1 1 U2 6 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0884-3996 J9 J BIOLUM CHEMILUM JI J. Biolumin. Chemilumin. PD JUL-AUG PY 1995 VL 10 IS 4 BP 239 EP 245 DI 10.1002/bio.1170100407 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA RR741 UT WOS:A1995RR74100006 PM 8533605 ER PT J AU CHEICANTE, RL STUFF, JR DURST, HD AF CHEICANTE, RL STUFF, JR DURST, HD TI ANALYSIS OF CHEMICAL WEAPONS DEGRADATION PRODUCTS BY CAPILLARY ELECTROPHORESIS WITH UV DETECTION SO JOURNAL OF CAPILLARY ELECTROPHORESIS LA English DT Article DE CAPILLARY ZONE ELECTROPHORESIS; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; CHEMICAL WEAPONS DEGRADATION PRODUCTS; INDIRECT UV DETECTION; DIRECT UV DETECTION ID CHROMATOGRAPHY; SEPARATIONS; ACIDS AB CE with UV detection is investigated for the separation and detection of 27 chemical weapons (CW) degradation products. Both capillary zone electrophoresis (CZE) and micellar electrokinetic chromatography (MEKC) separation techniques are used with direct and indirect UV detection. Optimal buffer systems and instrumental conditions are established for a representative collection of chemical warfare degradation compounds. Anionic, cationic, zwitterionic, and neutral components are determined with either direct UV absorbance or indirect UV displacement. Sodium dodecyl sulfate is used as the micelle-forming surfactant, and phenylphosphonic acid is used as the background electrolyte in berate buffer solutions. This evaluation is designed to demonstrate the applicability of CE as an analytical method in CW detection. C1 EAI CORP,ABINGDON,MD. USA,MAT COMMAND TREATY LAB,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN,MD. NR 19 TC 9 Z9 9 U1 0 U2 1 PU I S C TECHNICAL PUBLICATIONS, INC PI SHELTON PA 30 CONTROLS DR, BOX 828, SHELTON, CT 06484-0828 SN 1079-5383 J9 J CAPILLARY ELECTROP JI J. Capillary Electrophor. PD JUL-AUG PY 1995 VL 2 IS 4 BP 157 EP 163 PG 7 WC Biochemistry & Molecular Biology; Electrochemistry SC Biochemistry & Molecular Biology; Electrochemistry GA TF378 UT WOS:A1995TF37800003 PM 9384769 ER PT J AU COHENADAD, R LORIMER, JW PHILLIPS, SL SALOMON, M AF COHENADAD, R LORIMER, JW PHILLIPS, SL SALOMON, M TI A CONSISTENT APPROACH TO TABULATION OF EVALUATED SOLUBILITY DATA - APPLICATION TO THE BINARY-SYSTEMS RBCL-H2O AND UO2(NO3)2-H2O SO JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES LA English DT Article ID 25-DEGREES-C AB Many scientific disciplines require accurate solubility data. However, the proliferation of published values from research over the past century reveals a need for a consistent approach to tabulation and evaluation of these data, along with recommended methods based on theory for interpolation and extrapolation. The approach used in the IUPAC Solubility Data project is described, using as examples the binary systems RbCl-H2O and UO2(NO3)(2)-H2O. In this approach, all relevant solubility data are compiled and tabulated. The tabulated data are then evaluated using a systematic approach based upon thermodynamics. The results are tables of recommended values and fitting equations for solubilities and, in some cases, corresponding densities and vapor pressures. C1 UNIV WESTERN ONTARIO,DEPT CHEM,LONDON,ON N6A 5B7,CANADA. UNIV LYON 1,PHYSICOCHIM MINERALE LAB,F-69622 VILLEURBANNE,FRANCE. CAMATX BASIC CHEM,ORINDA,CA 94563. USA,EPSD ARL,FT MONMOUTH,NJ 07703. NR 68 TC 4 Z9 4 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0095-2338 J9 J CHEM INF COMP SCI JI J. Chem. Inf. Comput. Sci. PD JUL-AUG PY 1995 VL 35 IS 4 BP 675 EP 696 DI 10.1021/ci00026a003 PG 22 WC Chemistry, Multidisciplinary; Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Chemistry; Computer Science GA RL825 UT WOS:A1995RL82500003 ER PT J AU MCGUIRE, WP HOSKINS, WJ BRADY, MF HOMESLEY, HD CREASMAN, WT BERMAN, ML BALL, H BEREK, JS WOODWARD, J AF MCGUIRE, WP HOSKINS, WJ BRADY, MF HOMESLEY, HD CREASMAN, WT BERMAN, ML BALL, H BEREK, JS WOODWARD, J TI ASSESSMENT OF DOSE-INTENSIVE THERAPY IN SUBOPTIMALLY DEBULKED OVARIAN-CANCER - A GYNECOLOGIC-ONCOLOGY-GROUP STUDY SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID CHEMOTHERAPY; CISPLATIN; CARCINOMA; CYCLOPHOSPHAMIDE; SURVIVAL AB Purpose: We report a prospective randomized trial in women with advanced ovarian cancer to evaluate the importance of chemotherapy dose-intensity on survival, progression-free survival (PFS), and response. Patients and Methods: A total of 485 patients with epithelial ovarian cancer and residual masses more than 1 cm following surgery (stage III presentation) or any stage IV presentation were randomly assigned to receive either standard therapy (cyclophosphamide 500 mg/m(2) and cisplatin 50 mg/m(2) intravenously every 3 weeks for eight courses) or intense therapy (cyclophosphamide 1,000 mg/m(2) and cisplatin 100 mg/m(2) intravenously every 3 weeks for four courses). Dose modification was rigidly controlled to maintain intensity. Clinical and pathologic responses were assessed, when appropriate, as well as PFS interval and survival. Results: A total of 458 patients met all eligibility criteria and were assessed for survival and PFS. The dose-intensive group received the same total dose of cyclophosphamide and cisplatin, but 1.97 times greater dose-intensity than the standard group. Clinical and pathologic response rates, response duration, and survival were similar in both groups of patients. Hematologic, gastrointestinal, febrile episodes, septic events, and renal toxicities were significantly more common and severe in the dose-intensive group. Conclusion: A doubling of the dose intensity in the treatment of bulky ovarian epithelial cancers led to no discernible improvement in patient outcome and was associated with more severe toxicity. This study provides no evidence to support the hypothesis that modest increases in dose-intensity without increasing total dose are associated with significant improvement in overall survival or PFS. C1 EMORY UNIV, DEPT MED, ATLANTA, GA 30322 USA. UNIFORMED SERV UNIV HLTH SCI, DEPT PATHOL, BETHESDA, MD 20814 USA. MEM SLOAN KETTERING CANC CTR, DEPT SURG, GYNECOL SERV, NEW YORK, NY 10021 USA. CORNELL UNIV, COLL MED, DEPT OBSTET & GYNECOL, NEW YORK, NY USA. ROSWELL PK CANC INST, GYNECOL ONCOL GRP, BUFFALO, NY 14263 USA. WAKE FOREST UNIV, CTR COMPREHENS CANC, GYNECOL ONCOL SECT, WINSTON SALEM, NC 27109 USA. MED UNIV S CAROLINA, DEPT OBSTET & GYNECOL, CHARLESTON, SC 29425 USA. UNIV CALIF IRVINE, DEPT OBSTET & GYNECOL, DIV GYNECOL ONCOL, IRVINE, CA 92717 USA. UNIV CALIF LOS ANGELES, JONSSON COMPREHENS CANC CTR, SCH MED, DEPT OBSTET & GYNECOL, LOS ANGELES, CA 90024 USA. TUFTS UNIV NEW ENGLAND MED CTR, DEPT OBSTET & GYNECOL, DIV GYNECOL ONCOL, BOSTON, MA 02111 USA. TUFTS UNIV, SCH MED, BOSTON, MA 02111 USA. WALTER REED ARMY MED CTR, DEPT ANAT PATHOL, WASHINGTON, DC 20307 USA. WAKE FOREST UNIV, DEPT OBSTET & GYNECOL, WINSTON SALEM, NC 27109 USA. FU NCI NIH HHS [CA 12534, CA 21946, CA 23765] NR 29 TC 189 Z9 192 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD JUL PY 1995 VL 13 IS 7 BP 1589 EP 1599 PG 11 WC Oncology SC Oncology GA RG157 UT WOS:A1995RG15700010 PM 7602348 ER PT J AU BYRD, JC EDENFIELD, WJ SHIELDS, DJ DAWSON, NA AF BYRD, JC EDENFIELD, WJ SHIELDS, DJ DAWSON, NA TI EXTRAMEDULLARY MYELOID CELL TUMORS IN ACUTE NONLYMPHOCYTIC LEUKEMIA - A CLINICAL REVIEW SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Review ID ACUTE MYELOGENOUS LEUKEMIA; ACUTE MYELOMONOCYTIC LEUKEMIA; GRANULOCYTIC SARCOMA CHLOROMA; CENTRAL-NERVOUS-SYSTEM; ACUTE MONOBLASTIC LEUKEMIA; BONE-MARROW TRANSPLANTATION; ACUTE MYELOBLASTIC-LEUKEMIA; ACUTE PROMYELOCYTIC LEUKEMIA; NON-LYMPHOCYTIC LEUKEMIA; HIGH-DOSE CYTARABINE AB Purpose: To discuss the predisposing risk factors for all forms of extramedullary leukemia (EML) and to review the clinical features, prognostic significance, and treatment strategies for primary EML and leukemia cutis (LC)/granulocytic sarcomas (GS) in the setting of acute nonlymphocytic leukemia (ANLL). Methods: A review of all reports published since 1965 related to all forms of extramedullary leukemia (LC, GS, gingival hypertrophy, and meningeal leukemia [ML]). Results: Several factors, including chromosomal abnormalities [t(8;21), inv(16)], cell-surface markers (CD56, CD2, CD4, CD7), French-American-British (FAB) subtype (M2, M4, M5), blast differentiation and maturation, patient nutritional status, age, cellular immune dysfunction, high presenting leukocyte count, and decreased blast Auer rods, have been associated with a higher incidence of EML. Of 154 published cases of primary EML identified, 71 (46%) were initially misdiagnosed. The addition of immunohistochemical stains can assist in preventing such misdiagnoses and should be included in all atypical lymphoma/carcinoma cases. Only one of the patients (3%) with primary EML did not progress to ANLL in the absence of chemotherapy. In contrast, 66% of patients who received chemotherapy for the primary EML never developed ANLL. The prognostic significance of EML at presentation and medullary relapse of ANLL is uncertain. isolated extramedullary recurrence of ANLL always heralds bone marrow relapse and should be treated with reinduction chemotherapy. Close clinical follow-up observation is necessary to insure resolution of EML. Radiation therapy is an effective local treatment for resistant or symptomatic EML. Conclusion: Many advances in diagnoses and treatment of EML have been made. Future investigations ore needed to define the clinical significance of EML in patients with ANLL treated with modern chemotherapy or bone marrow transplantation. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP BYRD, JC (reprint author), WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 243 TC 371 Z9 385 U1 0 U2 6 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD JUL PY 1995 VL 13 IS 7 BP 1800 EP 1816 PG 17 WC Oncology SC Oncology GA RG157 UT WOS:A1995RG15700035 PM 7602369 ER PT J AU BRAR, GS PALAZZO, AJ AF BRAR, GS PALAZZO, AJ TI SHOOT AND ROOT DEVELOPMENT OF TALL AND HARD FESCUES IN 2 DIFFERENT SOILS SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID SEEDLINGS AB Tall (Festuca arundinacea Schreb.) and hard fescue [Festuca ovina var. longifolia (L.) Koch] are among the most widely sown grasses used to stabilize disturbed soils in both the cool-humid and transition climatic zones of the USA. Our objective was to evaluate the root and shoot development of two turfgrasses grown in sand and silt loam soils. Significant differences in leaf area, plant height, shoot and root dry matter, root depth (RD), root branching (RB), and root length (RL) were recorded with tall fescue compared with hard fescue. Greater leaf area, leaf number, plant height, shoot and root dry matter, and RL were observed when the grasses were grown in a silt loam soil. Greater RD and root/shoot ratio were recorded in sandy soil. Both turfgrass species and soil texture affected leaf area, leaf number, plant height, shoot dry matter, RD, RL, RB, root dry matter, and the root/shoot ratio. Significant correlations were obtained for shoot dry matter with root dry matter and RL; leaf area with shoot dry matter and root dry matter; root dry matter with TRL and RB; RD with root/shoot ratio; RL with leaf area; and RB with TRL and RD. Turfgrasses and soil types had an significant impact on shoot and root development. A greater understanding of early root develop ment for these grasses will assist in developing techniques for establishment and persistence under disturbed soils and adverse climatic conditions. RP BRAR, GS (reprint author), USA,CORPS ENGINEERS,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 37 TC 6 Z9 6 U1 2 U2 8 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 SN 0047-2425 J9 J ENVIRON QUAL JI J. Environ. Qual. PD JUL-AUG PY 1995 VL 24 IS 4 BP 777 EP 781 PG 5 WC Environmental Sciences SC Environmental Sciences & Ecology GA RJ934 UT WOS:A1995RJ93400030 ER PT J AU MUNAVALLI, S ROSSMAN, DI SZAFRANIEC, LL BEAUDRY, WT ROHRBAUGH, DK FERGUSON, CP GRATZEL, M AF MUNAVALLI, S ROSSMAN, DI SZAFRANIEC, LL BEAUDRY, WT ROHRBAUGH, DK FERGUSON, CP GRATZEL, M TI MODIFIED ULLMANN COUPLING OF 2-CHLORO-3-TRIFLUOROMETHYLPYRIDINE SO JOURNAL OF FLUORINE CHEMISTRY LA English DT Article DE ULLMANN COUPLING; CHLOROTRIFLUOROMETHYLPYRIDINE; BIS(TRIFLUOROMETHYL)BIPYRIDINE; SYNTHESIS; NMR SPECTROSCOPY; MASS SPECTROMETRY ID GRIGNARD-REAGENTS; ELECTRON-TRANSFER; NICKEL-COMPLEXES; WATER; HETEROCYCLES; RUTHENIUM AB The application of the modified Ullmann reaction to 2-chloro-3-trifluoromethylpyridine furnishes 5,5'-bis(trifluoromethyl)-2,2'-bipyridine as the primary product, accompanied by small amounts of the expected 3,3'-bis(trifluoromethyl)-2,2'-bipyridine, 2-benzyl-3-(trifluoromethyl)pyridine, bibenzyl, 3-trifluoromethylpyridine, 3-methylpyridine, 2-hydroxyethyl-(3-trifluoromethylpyridyl) ether and 2-hydroxyethyl-(3-methylpyridyl) ether. For comparison purposes, a sample of 3,3'-bis-(trifluoromethyl)-2,2'bipyridyl was prepared by the treatment of 2,2'-bipyridyl-3,3'-dicarboxylic acid with sulfur tetrafluoride. The formation of all but two compounds mentioned above can be rationalized on the basis of the single-electron-transfer process. C1 USA,EDGEWOOD RES DEV ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. ECOLE POLYTECH FED LAUSANNE,INST CHIM PHYS,CH-1015 LAUSANNE,SWITZERLAND. RP MUNAVALLI, S (reprint author), GEOCENTERS INC,FT WASHINGTON,MD 20774, USA. RI Graetzel, Michael/G-4870-2011 NR 56 TC 14 Z9 14 U1 1 U2 6 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-1139 J9 J FLUORINE CHEM JI J. Fluor. Chem. PD JUL PY 1995 VL 73 IS 1 BP 1 EP 6 DI 10.1016/0022-1139(94)03168-Y PG 6 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA RL107 UT WOS:A1995RL10700002 ER PT J AU MUNAVALLI, S HASSNER, A ROSSMAN, DI SINGH, S ROHRBAUGH, DK FERGUSON, CP AF MUNAVALLI, S HASSNER, A ROSSMAN, DI SINGH, S ROHRBAUGH, DK FERGUSON, CP TI NOVEL REACTIONS OF PERFLUOROALKYLPHENYL SULFIDES WITH ORGANOLITHIUM REAGENTS SO JOURNAL OF FLUORINE CHEMISTRY LA English DT Article DE REACTIONS; PERFLUOROALKYLPHENYL SULFIDES; ORGANOLITHIUM REAGENTS; NMR SPECTROSCOPY; MASS SPECTROMETRY; ORTHOMETALLATION ID SINGLE ELECTRON-TRANSFER; S-S BONDS; METALATION REACTIONS; GRIGNARD-REAGENTS; ORTHO-LITHIATION; C-S; STEREOCONTROL; REGIOCONTROL; EQUIVALENTS; BENZENES AB The reaction of anisole with organolithium reagents, commonly known as ortho-directed metallation, is of considerable synthetic utility in organic chemistry and as such has attracted considerable attention in recent years. Over the past 50 years, several mechanisms have been proposed to account for the observed regioselective metallation. For the first time, the reaction of perfluoroalkylphenyl sulfides with organolithium reagents has been investigated and found to furnish products resulting from the replacement of the perfluoroalkyl moieties with alkyl groups derived from the metallating agents. Phenyltrifluoromethyl ether, the anisole analog, failed to undergo metallation. A rationalization for the formation of unusual products via mediation of a single-electron-transfer process is presented in this paper together with the spectral data of the products. C1 BAR ILAN UNIV,DEPT CHEM,IL-52900 RAMAT GAN,ISRAEL. USA,EDGEWOOD RES DEV ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. RP MUNAVALLI, S (reprint author), GEOCENTERS INC,FT WASHINGTON,MD 20774, USA. NR 58 TC 26 Z9 26 U1 1 U2 3 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-1139 J9 J FLUORINE CHEM JI J. Fluor. Chem. PD JUL PY 1995 VL 73 IS 1 BP 7 EP 11 DI 10.1016/0022-1139(94)03209-I PG 5 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA RL107 UT WOS:A1995RL10700003 ER PT J AU ZELENKA, RE YEE, Z ZIRKLER, A AF ZELENKA, RE YEE, Z ZIRKLER, A TI FLIGHT TEST OF RADAR ALTIMETER ENHANCEMENT FOR TERRAIN-REFERENCED GUIDANCE SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article AB Aircraft operations at low altitude near the terrain require high pilot workload and are Inherently of high risk, even in fair weather and nonhostile environments. To reduce crew workload and allow safer flight in this regime, an automated guidance system was developed that presents a low altitude trajectory to the pilot on a helmet-mounted display. The guidance trajectory is generated by employing a digital terrain elevation map subject to mission requirements and aircraft performance limits. The flight envelope of this system is principally limited by accuracy in above ground level (AGL) positioning of the aircraft. Errors of the terrain elevation map and airborne navigation systems restricted flight to above 300 ft AGL. In this work, a Kalman filter state estimator has been developed that blends a radar altimeter with the airborne navigation and stored terrain elevation data for improved AGL positioning. This AGL altitude state estimator was integrated in a near terrain guidance system aboard a U.S. Army helicopter and flight tested in moderately rugged terrain over a variety of flight and system conditions. The minimum operating altitude of this terrain database referenced guidance system was reduced to 150 ft with the addition of this radar altimeter-based Kalman filter state estimator. C1 USA,COMMAND CONTROL & SYST INTEGRAT DIRECTORATE,FT MONMOUTH,NJ 07703. VITRON INC,EATONTOWN,NJ 07724. RP ZELENKA, RE (reprint author), NASA,AMES RES CTR,MOFFETT FIELD,CA 94035, USA. NR 17 TC 3 Z9 3 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD JUL-AUG PY 1995 VL 18 IS 4 BP 702 EP 708 DI 10.2514/3.21450 PG 7 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA RP557 UT WOS:A1995RP55700009 ER PT J AU MAYNORD, ST AF MAYNORD, ST TI GABION-MATTRESS CHANNEL-PROTECTION DESIGN SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article AB A design procedure for sizing gabion mattresses is presented that is based on depth-averaged velocity in the same manner as the Corps of Engineers' 1991 riprap-design guidance. This allows variation of gabion-mattress rock size and thickness with cross-section shape, channel alignment, and side slope. Stability is based on size of rock in the gabion rather than thickness, and stability coefficients are determined from flume-test results. Recommended mattress thickness and rock gradation are also presented. RP MAYNORD, ST (reprint author), USA,ENGINEER WATERWAYS EXPT STN,RES HYDR ENGR HYDR LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 10 TC 4 Z9 4 U1 0 U2 5 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JUL PY 1995 VL 121 IS 7 BP 519 EP 522 DI 10.1061/(ASCE)0733-9429(1995)121:7(519) PG 4 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA RD136 UT WOS:A1995RD13600002 ER PT J AU KATZ, DM WATTS, FJ BURROUGHS, ER AF KATZ, DM WATTS, FJ BURROUGHS, ER TI EFFECTS OF SURFACE-ROUGHNESS AND RAINFALL IMPACT ON OVERLAND-FLOW SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article ID SIMULATOR AB Bed roughness and rainfall impact affect hydraulic friction in overland flow. The relationship between friction, velocity, discharge, and channel slope was examined for the case of shallow, spatially varied flow on rough surfaces. Rainfall was simulated on artificially roughened surfaces in a laboratory. Measured flow velocities were compared to theoretical velocities computed from a dynamic equation for spatially varied flow and from the Darcy-Weisbach uniform flow equation. The measurements showed that the constant that relates the Darcy-Weisbach friction coefficient to Reynolds number can become larger than the theoretical value for smooth laminar flow. An analysis of the dynamic equation showed that frictional forces were much larger than forces resulting from changes in hydrostatic pressure and momentum. Water-surface profiles based on the Darcy-Weisbach friction equation nearly matched those from the dynamic equation for spatially varied flow. A regression was developed from the Darcy-Weisbach equation. The regression accurately predicted flow velocity when absolute roughness, rainfall rate, channel discharge, slope, slope length, and viscosity were known. C1 UNIV IDAHO,DEPT CIVIL ENGN,MOSCOW,ID 83843. US FOREST SERV,INTERMT RES STN,MOSCOW,ID 83843. RP KATZ, DM (reprint author), USA,CORPS ENGINEERS,201 N 3RD ST,WALLA WALLA,WA 99362, USA. NR 19 TC 25 Z9 28 U1 1 U2 4 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JUL PY 1995 VL 121 IS 7 BP 546 EP 553 DI 10.1061/(ASCE)0733-9429(1995)121:7(546) PG 8 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA RD136 UT WOS:A1995RD13600006 ER PT J AU SHARMA, A SUNDARAM, ST ZHANG, YZ BRODMAN, BW AF SHARMA, A SUNDARAM, ST ZHANG, YZ BRODMAN, BW TI NITROCELLULOSE DEGRADATION BY A COCULTURE OF SCLEROTIUM-ROLFSII AND FUSARIUM-SOLANI SO JOURNAL OF INDUSTRIAL MICROBIOLOGY LA English DT Article DE NITRATE ESTER; NITROCELLULOSE; PROPELLANT; BIODEGRADATION; SCLEROTIUM ROLFSII; FUSARIUM SOLANI ID DENITRIFICATION; OXIDATION AB Aerobic degradation of nitrocellulose in submerged cultivation (31% in a 3-day period) was accomplished by a combination of Sclerotium rolfsii ATCC 24459 and Fusarium solani IFO 31093, Evidence for the degradation includes a decrease in the nitrocellulose weight, an increase in the biomass weight, and reduction of the pH to 2.0. The extent of nitrocellulose biodegradation was probably limited by the low pH produced when the buffering capacity of the culture medium was exhausted. C1 USA,CTR ARMAMENTS RES DEV & ENGN,PICATINNY ARSENAL,NJ 07806. GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. NR 21 TC 20 Z9 20 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HANTS, ENGLAND RG21 2XS SN 0169-4146 J9 J IND MICROBIOL JI J. Indust. Microbiol. PD JUL PY 1995 VL 15 IS 1 BP 1 EP 4 DI 10.1007/BF01570005 PG 4 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA RQ028 UT WOS:A1995RQ02800001 ER PT J AU GUNZENHAUSER, JD LONGFIELD, JN BRUNDAGE, JF KAPLAN, EL MILLER, RN BRANDT, CA AF GUNZENHAUSER, JD LONGFIELD, JN BRUNDAGE, JF KAPLAN, EL MILLER, RN BRANDT, CA TI EPIDEMIC STREPTOCOCCAL DISEASE AMONG ARMY TRAINEES, JULY 1989 THROUGH JUNE 1991 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID ACUTE RHEUMATIC-FEVER; GROUP-A STREPTOCOCCI; SHOCK-LIKE SYNDROME; UNITED-STATES; TOXIC SHOCK; M-PROTEIN; PENICILLIN-G; INFECTIONS; RESURGENCE; PYOGENES AB Outbreaks of group A streptococcal infection occurred at four of seven US Army basic training installations between 1 July 1989 and 30 June 1991. Study data were collected through a respiratory disease surveillance program and on-site epidemiologic investigations. Although hospitalizations were frequent (range, 191-334) during each outbreak, average rates of hospitalization were low (2.4-4.8 hospitalizations/1000 trainees/week). Outbreak-associated morbidity included streptococcal toxic shock syndrome (2 cases, 1 fatal), acute rheumatic fever (6), acute glomerulonephritis (1), scarlet fever (1), and numerous other invasive sequelae. Four serotypes of Streptococcus pyogenes (M-1, -3, -5, and -18) were identified; M-18 caused significant disease at 2 installations. Disease control was rapidly achieved through prophylaxis programs using benzathine penicillin G in nonallergic trainees. These outbreaks extend other reports that document an evolution of the nature and severity of circulating S. pyogenes in the United States. C1 WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC. USA,ARMY HLTH SERV COMMAND,FT SAM HOUSTON,TX. UNIV MINNESOTA,SCH MED,DEPT PEDIAT,MINNEAPOLIS,MN. UNIV MINNESOTA,SCH MED,WHO,COLLABORATING CTR REFERENCE & RES STREPTOCOCCI,MINNEAPOLIS,MN. USA,MED DEPT ACT,FT KNOX,KY. NR 55 TC 32 Z9 34 U1 1 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL PY 1995 VL 172 IS 1 BP 124 EP 131 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RF041 UT WOS:A1995RF04100017 PM 7797902 ER PT J AU SCHNEIDER, H CROSS, AS KUSCHNER, RA TAYLOR, DN SADOFF, JC BOSLEGO, JW DEAL, CD AF SCHNEIDER, H CROSS, AS KUSCHNER, RA TAYLOR, DN SADOFF, JC BOSLEGO, JW DEAL, CD TI EXPERIMENTAL HUMAN GONOCOCCAL URETHRITIS - 250 NEISSERIA-GONORRHOEAE MS11MKC ARE INFECTIVE SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID LIPOOLIGOSACCHARIDES; EXPRESSION; HETEROGENEITY; MENINGITIDIS; MEN AB Neisseria gonorrhoeae MS11mkA (mkA) expresses one 3.6-kDa lipooligosaccharide (LOS). Variant MS11mkC (mkC), expressing four larger LOSs, occurs in vitro among mkA at a frequency of 10(-3). Infectivity of these variants was compared in 2 groups of volunteers inoculated with similar to 40,000 piliated, Opa(-) gonococci of either strain. The mkC variant infected 5 of 5 while mkA infected only 2 (40%) of 5. Gonococci recovered from the mkA infections showed a transition toward the mkC LOS phenotype. The mkA inoculum contained similar to 40 mkC gonococci. These data confirmed earlier studies and suggested that small numbers of mkC gonococci would be infective. This hypothesis was tested in three more experiments. In two, volunteers were inoculated with 250 or 1250 mkC, infecting 3 of 7 in each group, and in the third, 1600 mkC infected 2 of 6, resulting in a total of 8 of 20 infected by less than or equal to 1600 mkC. Gonococci shed by infected volunteers maintained the mkC LOS phenotype but shifted from Opa(-) to Opa(+). Thus, LOS and opacity protein, as well as pilus, are gonococcal virulence factors. C1 WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC. RP SCHNEIDER, H (reprint author), WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 16 TC 45 Z9 46 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL PY 1995 VL 172 IS 1 BP 180 EP 185 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RF041 UT WOS:A1995RF04100024 PM 7797908 ER PT J AU RAMSEY, KH SCHNEIDER, H CROSS, AS BOSLEGO, JW HOOVER, DL STALEY, TL KUSCHNER, RA DEAL, CD AF RAMSEY, KH SCHNEIDER, H CROSS, AS BOSLEGO, JW HOOVER, DL STALEY, TL KUSCHNER, RA DEAL, CD TI INFLAMMATORY CYTOKINES PRODUCED IN RESPONSE TO EXPERIMENTAL HUMAN GONORRHEA SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID TUMOR-NECROSIS-FACTOR; INTERLEUKIN-6 RESPONSE; EPITHELIAL-CELLS; URINARY-TRACT; EXPRESSION; INDUCTION; RNA AB Inflammatory cytokine production in men was examined after intraurethral challenge of volunteers with Neisseria gonorrhoeae MS11mkA or MS11mkC. Increased interleukin (IL)-8, IL-6, and tumor necrosis factor-alpha (TNF-alpha) were detected in urine before the onset of symptoms and peaked simultaneously with the detection of IL-1 beta at the onset of symptoms. Urine cytokine levels returned to baseline or near baseline within 48 h after antibiotic therapy. In plasma, IL-8, TNF-alpha, IL-1 beta, and IL-6 were elevated at the onset of symptoms in 9, 5, 4, and 3 of 10 subjects, respectively, and returned to near normal within 48 h after treatment. IL-1 alpha and granulocyte-macrophage colony-stimulating factor were not consistently detected in urine or plasma after challenge. Cytokine mRNA transcripts in peripheral blood mononuclear cells were not altered by the infection. The findings suggest that IL-8, IL-6, and possibly TNF-alpha were produced at the local site of infection, whereas IL-1 beta was derived from infiltrating leukocytes, C1 WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC. NR 16 TC 74 Z9 75 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL PY 1995 VL 172 IS 1 BP 186 EP 191 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RF041 UT WOS:A1995RF04100025 PM 7797909 ER PT J AU DAULA, T MOFFITT, R AF DAULA, T MOFFITT, R TI ESTIMATING DYNAMIC-MODELS OF QUIT BEHAVIOR - THE CASE OF MILITARY REENLISTMENT SO JOURNAL OF LABOR ECONOMICS LA English DT Article ID FEDERAL-EMPLOYEES; JOB SEPARATION; CHOICE AB We estimate the effect of financial incentives for reenlistment on military retention rates using a stochastic dynamic programming model. We show that the computational burden of the model is relatively low even when estimated on panel data with unobserved heterogeneity. The estimates of the model show strong effects of military compensation, especially of retirement pay, on retention rates. We also compare our model with simpler-to-compute models and find that all give approximately the same fit but that our dynamic programming model gives more plausible predictions of policy measures that affect military and civilian compensation at future dates. C1 JOHNS HOPKINS UNIV,BALTIMORE,MD 21218. RP DAULA, T (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 18 TC 22 Z9 22 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0734-306X J9 J LABOR ECON JI J. Labor Econ. PD JUL PY 1995 VL 13 IS 3 BP 499 EP 523 DI 10.1086/298383 PG 25 WC Economics; Industrial Relations & Labor SC Business & Economics GA RM487 UT WOS:A1995RM48700005 ER PT J AU CHINNI, VR HUANG, TC WAI, PKA MENYUK, CR SIMONIS, GJ AF CHINNI, VR HUANG, TC WAI, PKA MENYUK, CR SIMONIS, GJ TI CROSSTALK IN A LOSSY DIRECTIONAL COUPLER SWITCH SO JOURNAL OF LIGHTWAVE TECHNOLOGY LA English DT Article ID INDUCED WAVE-GUIDES; ELIMINATION; WAVEGUIDES; TALK AB Crosstalk due to material absorption in a two-waveguide, symmetric directional coupler switch is investigated, In a material with absorption, it is not possible to completely eliminate the crosstalk by adjusting the coupling length, The coupling length for minimum crosstalk differs from that of lossless systems, Theoretical limits of the lowest achievable crosstalk and the corresponding coupling lengths are calculated, The results show that the effect of absorption on crosstalk is more severe when the devices are designed for low crosstalk, The increase in crosstalk due to absorption can be as high as 20 dB. The material absorption is thus a critical parameter in designing low crosstalk devices. C1 UNIV MARYLAND,DEPT ELECT ENGN,CATONSVILLE,MD 21228. UNIV MARYLAND,INST PLASMA RES,COLLEGE PK,MD 20742. USA,RES LAB,ADELPHI,MD 20783. OI Wai, Alex/0000-0002-4975-4175 NR 15 TC 61 Z9 61 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0733-8724 J9 J LIGHTWAVE TECHNOL JI J. Lightwave Technol. PD JUL PY 1995 VL 13 IS 7 BP 1530 EP 1535 DI 10.1109/50.400714 PG 6 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA RK698 UT WOS:A1995RK69800046 ER PT J AU TIDROW, SC WILBER, WD TAUBER, A SCHAUER, SN ECKART, DW FINNEGAN, RD PFEFFER, RL AF TIDROW, SC WILBER, WD TAUBER, A SCHAUER, SN ECKART, DW FINNEGAN, RD PFEFFER, RL TI OXYGEN DIFFUSION THROUGH DIELECTRICS - A CRITICAL PARAMETER IN HIGH CRITICAL-TEMPERATURE SUPERCONDUCTORS MULTILAYER TECHNOLOGY SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID PULSED LASER DEPOSITION; HIGH-TC SUPERCONDUCTORS; BA-CU-O; THIN-FILMS; TRACER DIFFUSION; SINGLE-CRYSTAL; SELF-DIFFUSION; BUFFER LAYERS; YBA2CU3O7-DELTA; ANISOTROPY AB We have studied the relative diffusion rates of oxygen through dielectric/buffer layers used in high critical temperature superconducting multilayer structures. Epitaxial bilayer films of dielectric (CeO2, LaGaO3, NdGaO3, LaAlO3, MgO, SrTiO3, LaLiTi2O6, or LaNaTi2O6) on YBa2Cu3O7-delta (YBCO) have been deposited onto (001) oriented single-crystal MgO substrates using pulsed laser deposition, These bilayers have been investigated for oxygen diffusion over the temperature range 350 to 650 degrees C by postdeposition annealing the films for 20 min in 0.5 atm of O-18 enriched molecular oxygen gas. Secondary ion mass spectroscopy was used to depth profile the relative concentration of O-18 to O-16 in each bilayer, Compared to YBCO, the dielectrics MgO, SrTiO3, LaLiTi2O6, and LaNaTi2O6 are relatively slow diffusers, while CeO2, LaGaO3, NdGaO3, and LaAlO3 are relatively fast diffusers. RP TIDROW, SC (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,EP EC H,FT MONMOUTH,NJ 07703, USA. RI Tidrow, Steven/C-8133-2013 NR 40 TC 12 Z9 13 U1 0 U2 12 PU MATERIALS RESEARCH SOCIETY PI PITTSBURGH PA 9800 MC KNIGHT ROAD SUITE 327, PITTSBURGH, PA 15237 SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD JUL PY 1995 VL 10 IS 7 BP 1622 EP 1634 DI 10.1557/JMR.1995.1622 PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA RE759 UT WOS:A1995RE75900009 ER PT J AU TURELL, MJ TAMMARIELLO, RF SPIELMAN, A AF TURELL, MJ TAMMARIELLO, RF SPIELMAN, A TI NONVASCULAR DELIVERY OF ST-LOUIS ENCEPHALITIS AND VENEZUELAN EQUINE ENCEPHALITIS VIRUSES BY INFECTED MOSQUITOS (DIPTERA, CULICIDAE) FEEDING ON A VERTEBRATE HOST27 SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE CULEX TARSALIS; AEDES TAENIORHYNCHUS; ST LOUIS ENCEPHALITIS VIRUS; VENEZUELAN EQUINE ENCEPHALITIS VIRUS; TRANSMISSION ID VALLEY FEVER VIRUS; CDNA CLONE; INGESTION AB We determined whether mosquitoes infected with the viruses St. Louis encephalitis (SLE) or Venezuelan equine encephalitis inoculate virus extravascularly or directly into the vascular system. Infected mosquitoes fed on the distal 3rd of the tails of suckling mice. Significantly more mice whose tails were amputated at the midpoint within 10 min of mosquito feeding survived than did siblings whose tails remained intact. Even when tails were amputated 1-6 h after SLE virus-infected mosquitoes fed, the median time to death was significantly longer in mice with amputated tails (7.1 d) than in mice with intact tails (5.8 d). We concluded that mosquitoes inoculated virus primarily extravascularly, rather than directly into the vascular system, while feeding on a vertebrate host. Extravascular, rather than intravascular, delivery of pathogens by mosquitoes may affect disease pathogenesis and vaccine efficacy. RP TURELL, MJ (reprint author), USA,MED RES INST INFECT DIS,DIV APPL RES,FREDERICK,MD 21702, USA. NR 17 TC 22 Z9 22 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 1995 VL 32 IS 4 BP 563 EP 568 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA RG291 UT WOS:A1995RG29100026 PM 7650720 ER PT J AU ROGERS, CJ AF ROGERS, CJ TI ARMS, ARMIES AND FORTIFICATIONS IN THE 100-YEARS-WAR - CURRY,A, HUGHES,M SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP ROGERS, CJ (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 1995 VL 59 IS 3 BP 522 EP 524 DI 10.2307/2944624 PG 3 WC History SC History GA RK430 UT WOS:A1995RK43000009 ER PT J AU POINDEXTER, EH AF POINDEXTER, EH TI CHEMICAL-REACTIONS OF HYDROGENOUS SPECIES IN THE SI/SIO2 SYSTEM SO JOURNAL OF NON-CRYSTALLINE SOLIDS LA English DT Article ID SI-SIO2 INTERFACE; CENTERS; DEFECTS; KINETICS; SILICON; SIO2 AB Recent studies involving hydrogen and its compounds in the Si/SiO2 system are examined as a basis for a comprehensive model of hydrogen physical chemistry in the system. A model will require resolution of contradictions among experimental findings on passivation of P-b centers, radiation damage mechanisms, diffusion, and physisorption and chemisorption in the SiO2 lattice. New findings on bias-temperature instability suggest approaches which may resolve some key problems. RP POINDEXTER, EH (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 21 TC 54 Z9 55 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-3093 J9 J NON-CRYST SOLIDS JI J. Non-Cryst. Solids PD JUL PY 1995 VL 187 BP 257 EP 263 DI 10.1016/0022-3093(95)00146-8 PG 7 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA RK195 UT WOS:A1995RK19500047 ER PT J AU SHIELS, WE AF SHIELS, WE TI CHILDHOOD INTUSSUSCEPTION - MANAGEMENT PERSPECTIVES IN 1995 SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION LA English DT Editorial Material ID REDUCTION; AIR; EXPERIENCE; ENEMA RP SHIELS, WE (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT RADIOL,WASHINGTON,DC 20307, USA. NR 12 TC 8 Z9 8 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0277-2116 J9 J PEDIATR GASTR NUTR JI J. Pediatr. Gastroenterol. Nutr. PD JUL PY 1995 VL 21 IS 1 BP 15 EP 17 DI 10.1097/00005176-199507000-00002 PG 3 WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics GA RJ016 UT WOS:A1995RJ01600002 PM 8576808 ER PT J AU STANNARD, JP CHRISTENSEN, KP WILKINS, KE AF STANNARD, JP CHRISTENSEN, KP WILKINS, KE TI FEMUR FRACTURES IN INFANTS - A NEW THERAPEUTIC APPROACH SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE FEMUR; FRACTURE; HARNESS; INFANT; PAVLIK AB Fourteen patients with 16 femur fractures sustained between birth and 18 months of age were treated with a Pavlik harness rather than traditional casting methods. All of the fractures went on to stable union within 5 weeks. Eleven fractures have been followed-up for >12 months, with a range of 12-30 months, and a mean of 20.1 months. All of the fractures healed in good alignment, with leg-length discrepancies <1 cm. There have been no adverse results or complications as a result of treatment with the Pavlik harness to treat femur fractures, including fractures of the proximal and middle thirds of the femur; and shortening of <2 cm. Advantages of the use of the Pavlik harness include ease of application without general anesthesia, minimal hospitalization, ease of reduction, ability to adjust the harness (and therefore the fracture alignment) if the reduction is lost, minimal cost, and ease of nursing, bonding with, and changing diapers on the infant. RP STANNARD, JP (reprint author), BROOKE ARMY MED CTR,ORTHOPAED SURG SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 22 Z9 26 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0271-6798 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD JUL-AUG PY 1995 VL 15 IS 4 BP 461 EP 466 PG 6 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA RE167 UT WOS:A1995RE16700010 PM 7560035 ER PT J AU DEMERS, DM BASS, JW VINCENT, JM PERSON, DA NOYES, DK STAEGE, CM SAMLASKA, CP LOCKWOOD, NH REGNERY, RL ANDERSON, BE AF DEMERS, DM BASS, JW VINCENT, JM PERSON, DA NOYES, DK STAEGE, CM SAMLASKA, CP LOCKWOOD, NH REGNERY, RL ANDERSON, BE TI CAT-SCRATCH DISEASE IN HAWAII - ETIOLOGY AND SEROEPIDEMIOLOGY SO JOURNAL OF PEDIATRICS LA English DT Article ID ROCHALIMAEA; NOV AB Objective: To study the etiology and seroepidemiology of cat-scratch disease (CSD) in Hawaii. Methods: Blood and fine-needle aspirate (FNA) from the lymph nodes of 39 consecutive patients with clinical CSD were cultured for Bartonella henselae, and blood samples from index cats, stray cats, and dogs were cultured and their sera were tested by indirect fluorescence antibody test for antibodies to B, henselae and Afipia tells. Sera from age- and sex-matched human subjects without cat exposure served as controls. Results: Warthin-Starry staining showed positive results in only 4 of 32 FNAs, and B. henselae was isolated from only one FNA specimen. All of 38 patients who had two or more sera tested had elevated titers of antibody to B. henselae. Only 1 of 48 human control sera had antibody to 8. henselae. Of 31 kittens, 21 had positive blood culture results and elevated antibody titers to B. henselae, Of three adult cats, all had negative blood culture results, but they had serologic evidence of past infection. Of 23 adult stray cats, 18 had elevated titers of antibody to B, henselae, but in only one was the blood culture result positive. Results of IFA tests were marginally positive for A. tells in 1 of 29 patients with CSD and in one adult stray cat and one dog. Conclusions: This study shows that the B, henselae IFA test is both highly sensitive and specific for the detection of infection caused by B, henselae and for the laboratory diagnosis of CSD, and that FNA is seldom helpful in confirming the diagnosis, We further demonstrated that CSD in Hawaii is due to B, henselae and that infection is directly linked to the scratch car bite of a kitten. Older cats seldom have bacteremia but often have serologic evidence of past infection. Our study fails to implicate dogs in the epidemiology of CSD in Hawaii, and A, tells was not etiologically implicated in CSD in the human subjects and animals we studied. C1 TRIPLER ARMY MED CTR, DEPT PEDIAT, HONOLULU, HI 96859 USA. TRIPLER ARMY MED CTR, DEPT MED, HONOLULU, HI 96859 USA. TRIPLER ARMY MED CTR, DEPT PATHOL, HONOLULU, HI 96859 USA. PACIFIC VET SERV SUPPORT AREA, FT SHAFTER, HI USA. CTR DIS CONTROL & PREVENT, VIRAL & RICKETTSIAL ZOONOSES BRANCH, ATLANTA, GA 30341 USA. RI Anderson, Burt/H-4449-2011 NR 10 TC 81 Z9 82 U1 2 U2 4 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD JUL PY 1995 VL 127 IS 1 BP 23 EP 26 DI 10.1016/S0022-3476(95)70251-2 PG 4 WC Pediatrics SC Pediatrics GA RH637 UT WOS:A1995RH63700003 PM 7608806 ER PT J AU BREAULT, LG SCHUSTER, GS BILLMAN, MA HANSON, BS KUDRYK, VL PASHLEY, DH RUNNER, RR MCPHERSON, JC AF BREAULT, LG SCHUSTER, GS BILLMAN, MA HANSON, BS KUDRYK, VL PASHLEY, DH RUNNER, RR MCPHERSON, JC TI THE EFFECTS OF INTRACANAL MEDICAMENTS, FILLERS, AND SEALERS ON THE ATTACHMENT OF HUMAN GINGIVAL FIBROBLASTS TO AN EXPOSED DENTIN SURFACE FREE OF A SMEAR LAYER SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE FIBROBLASTS; PERIODONTAL ATTACHMENT; WOUND HEALING; ROOT CANAL THERAPY ADVERSE EFFECTS; FORMOCRESOL ADVERSE EFFECTS; GUTTA PERCHA ADVERSE EFFECTS ID ROOT-CANAL SEALERS; ZINC OXIDE-EUGENOL; RADICULAR DENTIN; GUTTA-PERCHA; PERIODONTAL-LIGAMENT; CONNECTIVE-TISSUE; CALCIUM HYDROXIDE; CYTOTOXICITY; DIFFUSION; CELL AB TO DATE THERE HAS BEEN VERY LITTLE RESEARCH into the possible effects of endodontic therapy on regeneration of the lost periodontal attachment. The objective of this study was to examine the effects of endodontic medicaments on fibroblast attachment to dentin surfaces free of a smear layer. Pulp chambers of extracted third molars were filled with one of the following medicaments:gutta-percha with Roth's zinc oxide and eugenol-based sealer, warm gutta-percha with sealer, warm gutta-percha without sealer, calcium hydroxide, formocresol, cotton pellet, or left empty. A predetermined dentin surface area was then inoculated with human gingival fibroblasts at a concentration of 2 x 10(4) cells per mi. The cells were allowed to adhere to the dentin surface for either 4 or 24 hours, then cell attachment was quantified using a methyl-tetrazolium assay, The data were analyzed using a Kruskal-Wallis one-way analysis of variance and Dunn's multiple comparison test. It was determined that fibroblast attachment was significantly reduced when exposed to formocresol or warm gutta-percha without sealer at both the 4 and 24 hour interval (P less than or equal to 0.05). This suggests that the use of formocresol or warm gutta-percha without sealer in a root canal may impede periodontal wound healing and regeneration. C1 MED COLL GEORGIA,DEPT ORAL BIOL,AUGUSTA,GA 30912. DD EISENHOWER ARMY MED CTR,DEPT CLIN INVEST,FT GORDON,GA. RP BREAULT, LG (reprint author), USA,DENT ACTIV,PERIODONT RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. NR 46 TC 10 Z9 10 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD JUL PY 1995 VL 66 IS 7 BP 545 EP 551 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA RL625 UT WOS:A1995RL62500001 PM 7562345 ER PT J AU TERRY, T AF TERRY, T TI HOW TO HAVE FUN AT SCHOOL, FIND FREE TIME, AND GET GOOD GRADES TOO SO JOURNAL OF PROFESSIONAL ISSUES IN ENGINEERING EDUCATION AND PRACTICE LA English DT Article AB In today's competitive environment, businesses must adopt continuous improvement to succeed. As a result, engineering students must become familiar with continuous improvement to function in business when they graduate. The best way for them to learn is by putting these ideas into action in school. This paper presents a plan that shows students how to use their available time effectively, track their progress, foresee problems before they occur, and take action to prevent those problems. The paper is written primarily for students and has applications for all of education. I urge you to pass out copies of it to students you know and at ASCE Student Chapter meetings. C1 USA,CORPS ENGINEERS,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP TERRY, T (reprint author), USN,CIV ENGR CORPS,72 LYME RD,HANOVER,NH 03755, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 1052-3928 J9 J PROF ISS ENG ED PR JI J. Prof. Issues Eng. Educ. Pract. PD JUL PY 1995 VL 121 IS 3 BP 177 EP 182 DI 10.1061/(ASCE)1052-3928(1995)121:3(177) PG 6 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA RD999 UT WOS:A1995RD99900005 ER PT J AU VOGELGESANG, SA GUTIERREZ, J KLIPPLE, GL KATONA, IM AF VOGELGESANG, SA GUTIERREZ, J KLIPPLE, GL KATONA, IM TI POLYNEUROPATHY IN JUVENILE DERMATOMYOSITIS SO JOURNAL OF RHEUMATOLOGY LA English DT Note DE JUVENILE DERMATOMYOSITIS; NEUROPATHY; VASCULITIS ID CHILDHOOD DERMATOMYOSITIS; CAPILLARY ABNORMALITIES; POLYMYOSITIS; COMPLEMENT; NEUROPATHY; DISEASES; ANTIGEN AB We describe 2 patients in whom juvenile dermatomyositis (DM) was associated with well defined clinical polyneuropathies, and review the clinical and serological data. Light and electron microscopy were used to study muscle and nerve tissues from one patient. Neuropathy in our patients was associated with ulcerative skin lesions and elevated serum levels of factor VIII related antigen. Light microscopic studies of muscle revealed perifascicular atrophy and microinfarcts consistent with juvenile DM. Light microscopy of the affected sural nerve showed axonal degeneration. Electron microscopy of the same nerve demonstrated capillary endothelial inclusions characteristic of those observed as manifestations of early endothelial injury in juvenile DM muscle tissue. Polyneuropathy in patients with juvenile DM is a rare complication and is likely due to ischemia secondary to endothelial damage. C1 ARMED FORCES INST PATHOL,DEPT NEUROMUSCULAR PATHOL,WASHINGTON,DC 20306. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. RP VOGELGESANG, SA (reprint author), WALTER REED ARMY MED CTR,DEPT MED,USA MED CORPS RHEUMATOL SERV,WASHINGTON,DC 20307, USA. NR 24 TC 15 Z9 16 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO ON M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD JUL PY 1995 VL 22 IS 7 BP 1369 EP 1372 PG 4 WC Rheumatology SC Rheumatology GA RG246 UT WOS:A1995RG24600028 PM 7562774 ER PT J AU DAPRANO, A SALOMON, M MAURO, V AF DAPRANO, A SALOMON, M MAURO, V TI SOLVENT EFFECTS ON COMPLEXATION OF CROWN-ETHERS WITH LICLO4, NACLO4 AND KCLO4 IN METHANOL AND ACETONITRILE SO JOURNAL OF SOLUTION CHEMISTRY LA English DT Article DE ELECTROLYTIC; MOLAR AND IONIC CONDUCTANCE; ION PAIR AND COMPLEX ION FORMATION; 12-CROWN-4; 15-CROWN-5; LITHIUM; SODIUM AND POTASSIUM PERCHLORATE; ACETONITRILE; METHANOL; SOLVATION EFFECTS; ION SOLVATION; GIBBS ENERGIES OF TRANSFER ID MACROCYCLIC LIGAND COMPLEXES; NUCLEAR MAGNETIC-RESONANCE; ALKALI-METAL SALTS; STABILITY-CONSTANTS; PROPYLENE CARBONATE; NONAQUEOUS SOLVENTS; ION COMPLEXES; CONDUCTANCE; CATIONS; 15-CROWN-5 AB The thermodynamic formation constants K-f for complexation of Li+, Na+ and K+ with the crown ethers 12C4 and 15C5 have been determined in methanol and acetonitrile at 25 degrees C using precision conductivity data. The method permits evaluation of very small K-f values (e.g., K-f = 6.98 mol(-1)-dm(3) for LiClO4 + 12C4 in methanol) as well as fairly large values (e.g., K-f = 2.73x10(4) mol(-1)-dm(3) for NaClO4 + 15C5 in acetonitrile). The determination of K-f values from conductivity data takes into consideration the often neglected ion pair formation of both the uncomplexed and the complexed cations. Our results for K-f are generally consistent with previously reported values based on potentiometry, calorimetry and polarography, but there are significant differences in several cases which we attribute to neglect of ion association both for the uncomplexed or ''free'' cation K-a and the macrocyclic complexed cation K-a2. Our results are also consistent with the well known concepts relating the magnitude of K-f to both the cavity diameter and ion-solvent interactions. Limiting molar conductivities Lambda(2)(0) for the complex salt (M-crown ether) (ClO4) in both solvents were generally found to be smaller or very close to the corresponding quantity Lambda(1)(0) for the binary MClO(4)-solvent system. However, in methanol, single ion limiting molar conductivities for the cationic complexes lambda(2)(0) exhibit anomalous behavior which is attributed to solvation differences between ''free'' cations and complexed cations. C1 USA,EPSD ARL,POWER SOURCES LAB,AMSRL-EP-PB,FT MONMOUTH,NJ 07703. RP DAPRANO, A (reprint author), UNIV ROMA LA SAPIENZA,DEPT CHEM,PLE A MORO 5,I-00185 ROME,ITALY. NR 48 TC 28 Z9 28 U1 1 U2 16 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0095-9782 J9 J SOLUTION CHEM JI J. Solut. Chem. PD JUL PY 1995 VL 24 IS 7 BP 685 EP 702 DI 10.1007/BF00973236 PG 18 WC Chemistry, Physical SC Chemistry GA RQ706 UT WOS:A1995RQ70600007 ER PT J AU SEMMEL, RD WINKLER, RP AF SEMMEL, RD WINKLER, RP TI INTEGRATING REENGINEERED DATABASES TO SUPPORT DATA FUSION SO JOURNAL OF SYSTEMS AND SOFTWARE LA English DT Article ID ENTITY-RELATIONSHIP MODEL; UNIVERSAL AB Large information systems often require the fusion of multiple databases to achieve desired functionality. In this article, we focus on how automated query formulation capabilities may be realized over a set of fused databases. Reengineering issues related to database design and fusion are discussed, and a query formulation and design system known as QUICK is described. A case study is presented in which the logical schemas for two independent U.S. Army databases are reverse engineered into conceptual schemas that are subsequently used for data fusion and automatic query generation. In addition, enhanced methods that employ meta-level conceptual constructs to support reverse engineering, data fusion, and query formulation are described. C1 USA,RES LAB,ADELPHI,MD 20783. RP SEMMEL, RD (reprint author), JOHNS HOPKINS UNIV,APPL PHYS LAB,JOHNS HOPKINS RD,LAUREL,MD 20723, USA. NR 22 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0164-1212 J9 J SYST SOFTWARE JI J. Syst. Softw. PD JUL-AUG PY 1995 VL 30 IS 1-2 BP 127 EP 135 DI 10.1016/0164-1212(94)00121-3 PG 9 WC Computer Science, Software Engineering; Computer Science, Theory & Methods SC Computer Science GA RC945 UT WOS:A1995RC94500009 ER PT J AU NEWMAN, JE BRAGG, F AF NEWMAN, JE BRAGG, F TI BONDING AMALGAMS SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION LA English DT Letter RP NEWMAN, JE (reprint author), LTC DE,FT BRAGG,NC, USA. NR 0 TC 0 Z9 1 U1 0 U2 0 PU AMER DENTAL ASSN PI CHICAGO PA 211 E CHICAGO AVE, CHICAGO, IL 60611 SN 0002-8177 J9 J AM DENT ASSOC JI J. Am. Dent. Assoc. PD JUL PY 1995 VL 126 IS 7 BP 824 EP 826 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA RJ367 UT WOS:A1995RJ36700007 PM 7629355 ER PT J AU Strawn, RC Biswas, R AF Strawn, RC Biswas, R TI Computation of helicopter rotor acoustics in forward flight SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID STOKES AB This paper presents a new method for computing acoustic signals from helicopter rotors in forward flight. The aerodynamic and acoustic solutions in the near field are computed with a finite-difference solver for the Euler equations. A nonrotating cylindrical Kirchhoff surface is then placed around the entire rotor system, This Kirchhoff surface moves subsonically with the rotor in forward flight. The finite-difference solution is interpolated onto this cylindrical surface at each time step and a Kirchhoff integration is used to carry the acoustic signal to the far field. Computed values for highspeed impulsive noise show excellent agreement with model-rotor and flight-test experimental data, Results from the new method offer high accuracy with reasonable computer resource requirements. C1 NASA,AMES RES CTR,RIACS,MOFFETT FIELD,CA 94035. RP Strawn, RC (reprint author), USA,AFDD,NASA,AMES RES CTR,MOFFETT FIELD,CA, USA. NR 16 TC 9 Z9 10 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 1995 VL 40 IS 3 BP 66 EP 72 PG 7 WC Engineering, Aerospace SC Engineering GA TX639 UT WOS:A1995TX63900008 ER PT J AU POINDEXTER, EH WARREN, WL AF POINDEXTER, EH WARREN, WL TI PARAMAGNETIC POINT-DEFECTS IN AMORPHOUS THIN-FILMS OF SIO2 AND SI3N4 - UPDATES AND ADDITIONS SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID DANGLING-BOND CENTERS; RECHARGEABLE E' CENTERS; SILICON-NITRIDE FILMS; OXYGEN-VACANCY; THERMAL SIO2; BURIED SIO2; ELECTRON; DIOXIDE; HYDROGEN; RADIATION AB Recent research on point defects in thin films of silicon dioxide, silicon nitride, and silicon oxynitride on Si is presented and reviewed. In SiO2, it now clear that no one type of E' center is the sole source of radiation-induced positive charge; hydrogenous moieties or other types of E' are proposed. Molecular orbital theory and easy passivation of E' by H-2 suggest that released H might depassivate interface P-b sites. A charged E(delta)' center has been seen in Cl-free SIMOX (separation by implantation of oxygen) and thermal oxide films, and it is reassigned to an electron delocalized over four O-3=Si units around a fifth Si. In Si3N4, a new model for the amphoteric charging of . Si=N-3 moieties is based on local shifts in defect energy with respect to the Fermi level, arising from nonuniform composition; it does not assume negative U electron correlation. A new defect NN20 has been identified, with dangling orbital on a two-coordinated N atom bonded to another N. Silicon oxynitride defects are briefly presented. C1 SANDIA NATL LABS,ALBUQUERQUE,NM 87185. RP POINDEXTER, EH (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 55 TC 49 Z9 49 U1 2 U2 8 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD JUL PY 1995 VL 142 IS 7 BP 2508 EP 2516 DI 10.1149/1.2044326 PG 9 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA RJ355 UT WOS:A1995RJ35500073 ER PT J AU GARDNER, JW DINSMORE, RC AF GARDNER, JW DINSMORE, RC TI EVOLUTION OF THE CONCEPT OF THE FEBRILE SEIZURE AS IT DEVELOPED IN THE AMERICAN MEDICAL LITERATURE, 1800-1980 SO JOURNAL OF THE HISTORY OF MEDICINE AND ALLIED SCIENCES LA English DT Article ID CAUSATION; DISEASE C1 USA,WASHINGTON,DC 20310. RP GARDNER, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. FU NCI NIH HHS [2 T32 CA 09001-04] NR 82 TC 0 Z9 0 U1 0 U2 0 PU J HIST MED ALLIED SCI INC PI CANTON PA PO BOX 487, CANTON, MA 02021 SN 0022-5045 J9 J HIST MED ALL SCI JI J. Hist. Med. Allied Sci. PD JUL PY 1995 VL 50 IS 3 BP 340 EP 363 DI 10.1093/jhmas/50.3.340 PG 24 WC Health Care Sciences & Services; History & Philosophy Of Science SC Health Care Sciences & Services; History & Philosophy of Science GA RN056 UT WOS:A1995RN05600002 PM 7665876 ER PT J AU EGBERT, H CARUSO, H AF EGBERT, H CARUSO, H TI MIL-STD-810E - SIGNIFICANT CHANGES INCLUDED IN NOTICE-3 SO JOURNAL OF THE INSTITUTE OF ENVIRONMENTAL SCIENCES LA English DT Editorial Material RP EGBERT, H (reprint author), USA,TEST & EVALUAT COMMAND,AMSTE CT T,ABERDEEN PROVING GROUND,MD 21005, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INST ENVIRONMENTAL SCI PI MOUNT PROSPECT PA 940 E NORTHWEST HIGHWAY, MOUNT PROSPECT, IL 60056 SN 1052-2883 J9 J INST ENVIRON SCI JI J. Inst. Environ. Sci. PD JUL-AUG PY 1995 VL 38 IS 4 BP 10 EP 10 PG 1 WC Engineering, Environmental; Environmental Sciences; Instruments & Instrumentation SC Engineering; Environmental Sciences & Ecology; Instruments & Instrumentation GA RX832 UT WOS:A1995RX83200001 ER PT J AU DENTE, JV MCCUTCHEON, JL JAIN, AK AF DENTE, JV MCCUTCHEON, JL JAIN, AK TI VIBRATION QUALIFICATION OF COMMERCIAL COMPUTERS FOR USE IN MILITARY TACTICAL ENVIRONMENTS SO JOURNAL OF THE INSTITUTE OF ENVIRONMENTAL SCIENCES LA English DT Article DE VIBRATION; TACTICAL; COMPUTER; COMMERCIAL; MILITARY; WHEELED; TRACKED; VEHICLE; SURVIVABILITY; ISOLATORS AB Commercial computers are generally designed for commercial use and lack industry specification for tactical use, other than the shipping environment. In order to use commercial computers in rugged military tactical environments, appropriate mounting trays and fixtures with vibration isolators must be designed for installation in tactical wheeled and tracked vehicles. This paper describes the vibration test profiles used in testing a commercial computer and monitor, as isolated, to determine the survivability limitations of these components when subjected to simulated tactical wheeled and tracked vehicle vibration environments. RP DENTE, JV (reprint author), USA,CECOM,ENVIRONM TEST TEAM,FT MONMOUTH,NJ 07703, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INST ENVIRONMENTAL SCI PI MOUNT PROSPECT PA 940 E NORTHWEST HIGHWAY, MOUNT PROSPECT, IL 60056 SN 1052-2883 J9 J INST ENVIRON SCI JI J. Inst. Environ. Sci. PD JUL-AUG PY 1995 VL 38 IS 4 BP 18 EP 22 PG 5 WC Engineering, Environmental; Environmental Sciences; Instruments & Instrumentation SC Engineering; Environmental Sciences & Ecology; Instruments & Instrumentation GA RX832 UT WOS:A1995RX83200005 ER PT J AU BERNSTEIN, L AF BERNSTEIN, L TI CREATING CHINESE ETHNICITY - SUBEI PEOPLE IN SHANGHAI, 1850-1980 - HONIG,E SO JOURNAL OF URBAN HISTORY LA English DT Book Review RP BERNSTEIN, L (reprint author), USA,CTR COMBINED ARMS,HIST OFF,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 1 U2 4 PU SAGE PUBL INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 0096-1442 J9 J URBAN HIST JI J. Urban Hist. PD JUL PY 1995 VL 21 IS 5 BP 653 EP 658 DI 10.1177/009614429502100504 PG 6 WC History; History Of Social Sciences; Urban Studies SC History; Social Sciences - Other Topics; Urban Studies GA RH285 UT WOS:A1995RH28500005 ER PT J AU BERNSTEIN, L AF BERNSTEIN, L TI SHANGHAI ON STRIKE - THE POLITIES OF CHINESE LABOR - PERRY,EJ SO JOURNAL OF URBAN HISTORY LA English DT Book Review RP BERNSTEIN, L (reprint author), USA,CTR COMBINED ARMS,HIST OFF,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 1 U2 4 PU SAGE PUBL INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 0096-1442 J9 J URBAN HIST JI J. Urban Hist. PD JUL PY 1995 VL 21 IS 5 BP 653 EP 658 DI 10.1177/009614429502100504 PG 6 WC History; History Of Social Sciences; Urban Studies SC History; Social Sciences - Other Topics; Urban Studies GA RH285 UT WOS:A1995RH28500004 ER PT J AU GLAZIER, DB BAHNSON, RR MCLEOD, DG VONROEMELING, RW MESSING, EM ERNSTOFF, MS AF GLAZIER, DB BAHNSON, RR MCLEOD, DG VONROEMELING, RW MESSING, EM ERNSTOFF, MS TI INTRAVESICAL RECOMBINANT TUMOR-NECROSIS-FACTOR IN THE TREATMENT OF SUPERFICIAL BLADDER-CANCER - AN EASTERN-COOPERATIVE-ONCOLOGY-GROUP STUDY SO JOURNAL OF UROLOGY LA English DT Article DE BLADDER NEOPLASMS; TUMOR NECROSIS FACTOR ID BACILLUS CALMETTE-GUERIN; RECURRENCE; THERAPY AB We tested and proved the safety of recombinant human tumor necrosis factor given intravesically weekly for 11 weeks (dwell time 2 hours) for the treatment of superficial bladder cancer in 8 men and 1 woman 46 to 87 years old (mean age 69 years). Cohorts of 3 patients received 200, 400 and 1,000 mu g. recombinant human tumor necrosis factor. The maximal tolerated dose was not achieved. There were 9 episodes of urological symptoms, 8 of flu-like symptoms, 4 of headache and 3 of chest tightness. Hematological and gastrointestinal toxicities were minor, and no renal toxicity was encountered. Recombinant human tumor necrosis factor was safe to administer at doses up to 1,000 mu g. We hope that recombinant human tumor necrosis factor in conjunction with other antitumor agents will lead to a new, effective treatment for superficial bladder cancer. C1 NORRIS COTTON CANC CTR,DEPT SURG,UROL SECT,LEBANON,NH 03756. NORRIS COTTON CANC CTR,DEPT MED,HEMATOL ONCOL SECT,LEBANON,NH 03756. UNIV PITTSBURGH,SCH MED,DEPT UROL SURG,PITTSBURGH,PA. STERLING WINTHROP INC,DEPT CLIN RES,UROL SECT,COLLEGEVILLE,PA. WALTER REED ARMY MED CTR,DIV UROL,WASHINGTON,DC 20307. UNIV WISCONSIN,SCH MED,MADISON,WI. FU NCI NIH HHS [CA21115, CA23318, K08 CA 01490] NR 20 TC 13 Z9 13 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUL PY 1995 VL 154 IS 1 BP 66 EP 68 DI 10.1016/S0022-5347(01)67228-8 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA RB819 UT WOS:A1995RB81900022 PM 7776458 ER PT J AU MICHAEL, NL CHANG, G DARCY, LA EHRENBERG, PK MARIANI, R BUSCH, MP BIRX, DL SCHWARTZ, DH AF MICHAEL, NL CHANG, G DARCY, LA EHRENBERG, PK MARIANI, R BUSCH, MP BIRX, DL SCHWARTZ, DH TI DEFECTIVE ACCESSORY GENES IN A HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED LONG-TERM SURVIVOR LACKING RECOVERABLE VIRUS SO JOURNAL OF VIROLOGY LA English DT Article ID PROTEIN INDUCES DEGRADATION; VPU-INDUCED DEGRADATION; SURFACE CD4 EXPRESSION; DOWN-REGULATION; CYTOPLASMIC DOMAIN; MUTATIONAL ANALYSIS; TRANSGENIC MICE; HIV-1 INFECTION; NEF GENE; REQUIREMENT AB We have been studying a patient who acquired human immunodeficiency virus (HIV) infection via a blood transfusion 13 years ago. She has remained asymptomatic since that time. The blood donor and two other recipients have all died of AIDS. Although this patient has shown persistently strong seroreactivity to HIV type 1 (HIV-1) antigens by Western blot (immunoblot), she has been continually HIV culture negative in results from multiple laboratories over the last 6 years and has a very low viral burden. Her CD4(+) T-cell count has fluctuated around a mean of 399 cells per mu l, with little change in lymphocyte subset percentages. Strong cellular immune responses to HIV-1 epitopes by this patient have been demonstrated. We now report the results of an intensive molecular genetic analysis of the HIV-1 proviral quasispecies from this patient sampled over 5 years. Long terminal repeat region sequences supported the argument for normal basal and Tat-mediated promoter activities. Sequential sequencing of the nef gene revealed a low frequency (8.3%) of defective genes and a striking lack of sequence evolution, Functional analysis of predominant nef genes by both a cell surface CD4 downregulation and a viral infectivity complementation assay showed wild-type function. In contrast, sequential analysis of an amplicon containing the vif, vpr, vpu, tat1, and rev1 genes revealed the presence of inactivating mutations in 64% of the clones. These data suggest that this patient, initially infected with a virulent swarm of HIV-1, is presently infected with a more-attenuated viral quasispecies as a result of effective host immunity. C1 HENRY M JACKSON FDN, ROCKVILLE, MD USA. JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, DEPT MOLEC MICROBIOL & IMMUNOL, BALTIMORE, MD USA. COLD SPRING HARBOR LAB, COLD SPRING HARBOR, NY 11724 USA. IRWIN MEM BLOOD CTR, SAN FRANCISCO, CA USA. RP MICHAEL, NL (reprint author), WALTER REED ARMY INST RES, DIV RETROVIROL, 13 TAFT CT, SUITE 200, ROCKVILLE, MD 20850 USA. FU NIAID NIH HHS [N01-AI-05061, R01 AI32388-02] NR 69 TC 103 Z9 103 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD JUL PY 1995 VL 69 IS 7 BP 4228 EP 4236 PG 9 WC Virology SC Virology GA RC226 UT WOS:A1995RC22600034 PM 7769682 ER PT J AU HUGHES, SA FOWLER, JE AF HUGHES, SA FOWLER, JE TI ESTIMATING WAVE-INDUCED KINEMATICS AT SLOPING STRUCTURES SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article ID REFLECTION; SLOPES AB This paper provides a technique for the estimation of root-mean-squared velocity parameters associated with irregular waves that have been reflected by coastal structures. A previously published first-order expression for estimating root-mean-squared water velocities beneath normally incident and reflected nonbreaking irregular waves by Hughes has been empirically augmented so that estimates can be made for the case of smooth impermeable plane sloping revetments and permeable rubble-mound cross sections. Empirical relationships for reflection coefficient and reflection phase were developed based on measurements obtained during laboratory experiments. These relationships, when used in the theoretical formulations, gave reasonable estimates of RMS velocity compared to measured laboratory data. The procedure given in this paper can be applied with a minimum of computational effort, and it provides realistic estimates of irregular wave kinematics near coastal structures. The capability to make these velocity estimates, particularly near the seabed, provides practicing engineers with an improved tool for addressing such problems as scour potential at structure toes and design of suitable scour blankets. RP HUGHES, SA (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180, USA. NR 13 TC 21 Z9 23 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JUL-AUG PY 1995 VL 121 IS 4 BP 209 EP 215 DI 10.1061/(ASCE)0733-950X(1995)121:4(209) PG 7 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA RE376 UT WOS:A1995RE37600003 ER PT J AU MAUSSHARDT, S SINGLETON, G AF MAUSSHARDT, S SINGLETON, G TI MITIGATING SALT-WATER-INTRUSION THROUGH HIRAM-M-CHITTENDEN-LOCKS SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Note AB The Seattle metropolitan area surrounds Lake Washington, a large freshwater lake connected to the salt water of Puget Sound by an 8-mi-long ship canal with a lock-and-dam structure at the downstream end of the canal. When raising vessels from Puget Sound to lake level, a strong current of salt water flows from the lock chamber into the freshwater system resulting in two opposing water-management issues at the locks: salt-water intrusion and water conservation. Several physical structures are present to prevent salt water from propagating upstream with each lake-bound lockage. During heavy use in the summer period, these structures cannot keep up with the amount of seawater entering the freshwater system, and an additional flushing technique is required. Consequently, the U.S. Army Corps of Engineers, which manages the locks, has implemented a ''miniflushing'' procedure for summer months. Miniflushing is defined as any process that can be temporarily implemented as part of a lockage to minimize salt-water intrusion. Recent field experiments at the locks compare two methods of miniflushing, and a recent improvement in procedure is discussed in this paper. C1 USA,CORPS ENGRS,WATER MGMT SECT,SEATTLE,WA 98124. RP MAUSSHARDT, S (reprint author), UNIV WASHINGTON,HARRIS HYDROL LAB,SEATTLE,WA 98195, USA. NR 6 TC 3 Z9 3 U1 0 U2 3 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JUL-AUG PY 1995 VL 121 IS 4 BP 224 EP 227 DI 10.1061/(ASCE)0733-950X(1995)121:4(224) PG 4 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA RE376 UT WOS:A1995RE37600005 ER PT J AU PERSON, DA AF PERSON, DA TI SYSTEMIC JUVENILE RHEUMATOID-ARTHRITIS (STILLS DISEASE) SO LANCET LA English DT Letter RP PERSON, DA (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0099-5355 J9 LANCET JI Lancet PD JUL 1 PY 1995 VL 346 IS 8966 BP 62 EP 62 DI 10.1016/S0140-6736(95)92699-2 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA RF985 UT WOS:A1995RF98500063 PM 7603179 ER PT J AU KARAYIGITOGLU, CF KOMMAREDDI, N GONZALEZ, RD JOHN, VT MCPHERSON, GL AKKARA, JA KAPLAN, DL AF KARAYIGITOGLU, CF KOMMAREDDI, N GONZALEZ, RD JOHN, VT MCPHERSON, GL AKKARA, JA KAPLAN, DL TI THE MORPHOLOGY OF PHENOLIC POLYMERS ENZYMATICALLY SYNTHESIZED IN SURFACTANT MICROSTRUCTURES SO MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC MATERIALS SENSORS AND SYSTEMS LA English DT Article DE PHENOLIC POLYMERS; MORPHOLOGY; SURFACTANT MICROSTRUCTURES AB Currently, there is much interest in materials synthesis through biomimetic pathways [1,2]. Biological and biomimetic routes to polymer and particle synthesis lead to materials with novel structural properties that can be replicated with rather high fidelity [3]. We report morphological characteristics of the enzymatic synthesis of phenolic polymers in the microstructured environment of water-in-oil microemulsions or reversed micelles. The enzyme, horseradish peroxidase, is encapsulated in the micelles. The synthesis appears to be an example of interfacial polymerization as the monomer partitions to the micelle oil-water interface. The final polymer has the interesting morphology of interconnected spherical particles. The microstructured environment appears to play an important role in morphology development, and a high surfactant to monomer ratio (>3:1) allows the formation of spherical morphologies. C1 TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RI John, Vijay/G-3747-2010 NR 11 TC 20 Z9 20 U1 0 U2 4 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0928-4931 J9 MAT SCI ENG C-BIOMIM JI Mater. Sci. Eng. C-Biomimetic Mater. Sens. Syst. PD JUL PY 1995 VL 2 IS 3 BP 165 EP 171 DI 10.1016/0928-4931(95)00058-5 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA RP793 UT WOS:A1995RP79300005 ER PT J AU ARBOGAST, T CHEN, ZX AF ARBOGAST, T CHEN, ZX TI ON THE IMPLEMENTATION OF MIXED METHODS AS NONCONFORMING METHODS FOR 2ND-ORDER ELLIPTIC PROBLEMS SO MATHEMATICS OF COMPUTATION LA English DT Article DE FINITE ELEMENT; IMPLEMENTATION; MIXED METHOD; EQUIVALENCE; NONCONFORMING METHOD; MULTIGRID METHOD ID FINITE-ELEMENT METHODS; LOWEST-ORDER; EQUATIONS; VARIABLES; FAMILY AB In this paper we show that mixed finite element methods for a fairly general second-order elliptic problem with variable coefficients can be given a nonmixed formulation, (Lower-order terms are treated, so our results apply also to parabolic equations,) We define an approximation method by incorporating some projection operators within a standard Galerkin method, which we call a projection finite element method. It is shown that for a given mixed method, if the projection method's finite element space M(h) satisfies three conditions, then the two approximation methods are equivalent. These three conditions can be simplified for a single element in the case of mixed spaces possessing the usual vector projection operator. We then construct appropriate nonconforming spaces M(h) for the known triangular and rectangular elements. The lowest-order Raviart-Thomas mixed solution on rectangular finite elements in R(2) and R(3), on simplices, or on prisms, is then implemented as a nonconforming method modified in a simple and computationally trivial manner. This new nonconforming solution is actually equivalent to a postprocessed version of the mixed solution. A rearrangement of the computation of the mixed method solution through this equivalence allows us to design simple and optimal-order multigrid methods for the solution of the linear system. C1 UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55415 USA. RP ARBOGAST, T (reprint author), RICE UNIV, DEPT COMPUTAT & APPL MATH, HOUSTON, TX 77251 USA. NR 22 TC 87 Z9 92 U1 0 U2 2 PU AMER MATHEMATICAL SOC PI PROVIDENCE PA 201 CHARLES ST, PROVIDENCE, RI 02940-2213 SN 0025-5718 J9 MATH COMPUT JI Math. Comput. PD JUL PY 1995 VL 64 IS 211 BP 943 EP 972 DI 10.2307/2153478 PG 30 WC Mathematics, Applied SC Mathematics GA RJ128 UT WOS:A1995RJ12800003 ER PT J AU NINDL, BC MAHAR, MT HARMAN, EA PATTON, JF AF NINDL, BC MAHAR, MT HARMAN, EA PATTON, JF TI SCALING ANAEROBIC PERFORMANCE FOR DIFFERENCES IN BODY DIMENSIONS - RESPONSE SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Letter C1 E CAROLINA UNIV,SCH HLTH & HUMAN PERFORMANCE,GREENVILLE,NC 27858. RP NINDL, BC (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT PHYSIOL,NATICK,MA 01760, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JUL PY 1995 VL 27 IS 7 BP 1099 EP 1100 DI 10.1249/00005768-199507000-00024 PG 2 WC Sport Sciences SC Sport Sciences GA RK055 UT WOS:A1995RK05500024 ER PT J AU OAKES, KS CHRISTENSEN, LC AF OAKES, KS CHRISTENSEN, LC TI RETROSPECTIVE EVALUATION OF OSSEOINTEGRATED IMPLANTS FOR TREATMENT OF PARTIAL AND FULL EDENTULISM AT WALTER-REED-ARMY-MEDICAL-CENTER .1. PATIENT RECALL SO MILITARY MEDICINE LA English DT Article AB A retrospective study was done on patients treated with dental implants at Waiter Reed Army Medical Center. An extensive recall of patients treated was accomplished. Each patient was clinically evaluated, radiographs were made, and the patients were asked to complete a survey. The results were not statistically analyzed but are reported simply as raw data. RP OAKES, KS (reprint author), US DENT ACTIV,WALTER REED ARMY MED CTR,ADV EDUC PROGRAM PROSTHODONT,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1995 VL 160 IS 7 BP 355 EP 358 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA RM138 UT WOS:A1995RM13800010 PM 7659243 ER PT J AU ZADOO, VP AF ZADOO, VP TI MEDIASTINAL ANGIOMATOSIS SO MILITARY MEDICINE LA English DT Note AB Angiomatosis is a poorly understood entity belonging to the vascular tumor family. It has never been described occurring in the mediastinum until this case report. Features unique to this tumor are described in this article, including a high recurrence rate after resection. The surgeon encountering this unusual tumor should attempt wide local excision at the time of surgery. Close follow-up for recurrence is highly recommended. RP ZADOO, VP (reprint author), TRIPLER ARMY MED CTR,GEN SURG SERV,HONOLULU,HI 96859, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1995 VL 160 IS 7 BP 362 EP 363 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA RM138 UT WOS:A1995RM13800012 PM 7659245 ER PT J AU ULRICH, RG BAVARI, S OLSON, MA AF ULRICH, RG BAVARI, S OLSON, MA TI STAPHYLOCOCCAL ENTEROTOXIN-A AND ENTEROTOXIN-B SHARE A COMMON STRUCTURAL MOTIF FOR BINDING CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX-MOLECULES SO NATURE STRUCTURAL BIOLOGY LA English DT Article ID TOXIC SHOCK SYNDROME; HLA-DR; T-CELLS; SUPERANTIGEN; IDENTIFICATION; SITES AB A comparative site-directed mutagenesis study of staphylococcal enterotoxins A and B was undertaken to identify key amino-acid residues which govern interactions with major histocompatibility class II molecules. This involved generating a three-dimensional homology model for enterotoxin A in complex with the HLA-DR1 molecule, based on the reported X-ray crystal structures of enterotoxin B, both free and bound to HLA-DR1. A binding motif previously described for enterotoxin B was found to be conserved in enterotoxin A. An examination of the experimental data with the homology model clarifies how T-cell responses to enterotoxin A, and most bacterial superantigens, are likely to be mediated by variations of a structurally conserved HLA-DR alpha binding motif. C1 USA,MED RES INST INFECT DIS,DEPT BIOCHEM & CELL BIOL,FREDERICK,MD 21702. RP ULRICH, RG (reprint author), USA,MED RES INST INFECT DIS,DEPT IMMUNOL & MOLEC BIOL,BLDG 1424-FCRDC,FREDERICK,MD 21702, USA. NR 31 TC 54 Z9 56 U1 0 U2 2 PU NATURE PUBLISHING CO PI NEW YORK PA 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 SN 1072-8368 J9 NAT STRUCT BIOL JI Nat. Struct. Biol. PD JUL PY 1995 VL 2 IS 7 BP 554 EP 560 DI 10.1038/nsb0795-554 PG 7 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA TD550 UT WOS:A1995TD55000009 PM 7664123 ER PT J AU Luckett, JA AF Luckett, JA TI Free people of color: Inside the African American community - Horton,JO SO NEW YORK HISTORY LA English DT Book Review RP Luckett, JA (reprint author), US MIL ACAD,DEPT HIST,W POINT,NY, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK STATE HIST ASSN PI COOPERSTOWN PA PO BOX 800, COOPERSTOWN, NY 13326-0800 SN 0146-437X J9 NEW YORK HIST JI N. Y. Hist. PD JUL PY 1995 VL 76 IS 3 BP 331 EP 333 PG 3 WC History SC History GA WD652 UT WOS:A1995WD65200009 ER PT J AU WALTON, TL AF WALTON, TL TI A TALE OF 2 WAVE-TRAINS SO OCEAN ENGINEERING LA English DT Article ID NATURAL BEACH; WATER; SWASH AB The present study is an investigation into the transfer of the wave energy as it propagates through the surf zone and the consequent evolution of the wave trains and the corresponding envelope of the wave trains. The generation of long wave energy is investigated and one approach to developing the nonlinear transfer function for the transformation process is attempted. A nondimensionalized format for expressing the data is suggested for clarifying future studies of this type. RP WALTON, TL (reprint author), USA,CORPS ENGINEERS,COASTAL ENGN RES CTR,USAE WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 20 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD JUL PY 1995 VL 22 IS 5 BP 457 EP 488 DI 10.1016/0029-8018(94)00021-X PG 32 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA QM385 UT WOS:A1995QM38500003 ER PT J AU ALTHOUSE, MLG CHANG, CI AF ALTHOUSE, MLG CHANG, CI TI TARGET DETECTION IN MULTISPECTRAL IMAGES USING THE SPECTRAL COOCCURRENCE MATRIX AND ENTROPY THRESHOLDING SO OPTICAL ENGINEERING LA English DT Article DE INFRARED; MULTISPECTRAL; DETECTION; VAPOR COOCCURRENCE; CHEMICAL; ENTROPY; SEGMENTATION ID SEGMENTATION AB Relative entropy thresholding techniques have been used for segmentation of objects from background in gray-level images. These techniques are related to entropy-based segmentations computed for the statistics of a spatial co-occurrence matrix. For detection of spectrally active targets such as chemical vapor clouds in multispectral or hyperspectral imagery, a spectral co-occurrence matrix is employed. Using the entropy of various regions of the matrix, thresholds can be derived that will segment an image family based on the spectral characteristics of the intended target. Experiments are presented that show the detection of a chemical vapor cloud in multispectral thermal imagery. Several manners of dividing the co-occurrence matrix into regions are explored. Thresholds are determined on both a local and global basis and compared. Locally generated thresholds are treated as a distribution and separated into classes. The point of class separation is used as a global threshold with improved results. C1 UNIV MARYLAND,DEPT ELECT ENGN,CATONSVILLE,MD 21228. RP ALTHOUSE, MLG (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD-RTE,BLDG E5554,ABERDEEN PROVING GROUND,MD 21010, USA. NR 16 TC 4 Z9 4 U1 3 U2 5 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUL PY 1995 VL 34 IS 7 BP 2135 EP 2148 DI 10.1117/12.206579 PG 14 WC Optics SC Optics GA RJ305 UT WOS:A1995RJ30500038 ER PT J AU WILLARD, CC FOSS, RD HOBBS, TJ AUCLAIR, PL RILEY, F AF WILLARD, CC FOSS, RD HOBBS, TJ AUCLAIR, PL RILEY, F TI PRIMARY ANAPLASTIC LARGE-CELL (KI-1 POSITIVE) LYMPHOMA OF THE MANDIBLE AS THE INITIAL MANIFESTATION OF ACQUIRED-IMMUNODEFICIENCY-SYNDROME IN A PEDIATRIC-PATIENT SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS LA English DT Article ID CLINICAL-FEATURES; AIDS AB A case of an anaplastic large-cell lymphoma with Ki-1 immunobistochemical reactivity presenting in the mandible of a 12-year-old girl with Waiter Reed Stage 6 human immunodeficiency virus infection is described. C1 USN,NATL DENT CTR,DEPT ORAL PATHOL,BETHESDA,MD. USA,DENT ACTIV,FT RILEY,KS. RP WILLARD, CC (reprint author), ARMED FORCES INST PATHOL,DEPT ORAL PATHOL,WASHINGTON,DC 20306, USA. NR 14 TC 12 Z9 12 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD JUL PY 1995 VL 80 IS 1 BP 67 EP 70 DI 10.1016/S1079-2104(95)80018-2 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA RJ493 UT WOS:A1995RJ49300017 PM 7552865 ER PT J AU ARRINGTON, ED MILLER, MD AF ARRINGTON, ED MILLER, MD TI SKELETAL-MUSCLE INJURIES SO ORTHOPEDIC CLINICS OF NORTH AMERICA LA English DT Article ID ACUTE RENAL-FAILURE; MYOSITIS-OSSIFICANS; STRAIN INJURY; RHABDOMYOLYSIS; EXERCISE; MYOGLOBINURIA; SORENESS AB Muscular injuries are extremely common in athletes. Treatment of these injuries is based on a solid understanding of anatomy, physiology, and healing of skeletal muscle. Injuries discussed include contusions, hematomas, myositis ossificans, delayed onset soreness, strain, rhabdomyolysis, and lacerations. Diagnosis and treatment of these injuries is essential for the sports medicine physicina. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. USAF ACAD,DEPT ORTHOPAED SURG,COLORADO SPRINGS,CO 80840. RP ARRINGTON, ED (reprint author), BROOKE ARMY MED CTR,ORTHOPAED SURG SERV,FT SAM HOUSTON,TX 78234, USA. NR 79 TC 28 Z9 29 U1 1 U2 3 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0030-5898 J9 ORTHOP CLIN N AM JI Orthop. Clin. North Am. PD JUL PY 1995 VL 26 IS 3 BP 411 EP 422 PG 12 WC Orthopedics SC Orthopedics GA RK060 UT WOS:A1995RK06000002 PM 7609956 ER PT J AU COLE, DM DURELL, GD AF COLE, DM DURELL, GD TI THE CYCLIC LOADING OF SALINE ICE SO PHILOSOPHICAL MAGAZINE A-PHYSICS OF CONDENSED MATTER STRUCTURE DEFECTS AND MECHANICAL PROPERTIES LA English DT Article ID INTERNAL-FRICTION; STRESS ASYMMETRY; GRAIN-BOUNDARIES; SINGLE-CRYSTALS; DEFORMATION; DISLOCATIONS; BEHAVIOR; SAMPLES; FATIGUE; COPPER AB This paper details the results of an experimental programme to investigate the constitutive behaviour of saline ice under reversed direct-stress conditions. The test material was laboratory-grown saline (NaCl) ice. The work explored the effects of temperature (from - 5 to - 50 degrees C), cyclic stress amplitude (0 . 1-0 . 8 MPa) and loading frequency (10(-3)-1 Hz) on the response of the ice. Variations in the ice growth conditions allowed the effects of microstructural variations to be investigated as well, with total porosity in the range 30-104 ppt. The experiments were generally performed by applying a sinusoidally varying uniaxial load, oscillating about zero, to the cylindrical specimens. Several experiments employed cyclic strain control. The material response was typically composed of elastic and anelastic strain, with various degrees of permanent or viscous strain occurring at higher temperatures and lower frequencies, and proved to be very sensitive to variations in loading conditions and to microstructural variations. An increase in total porosity caused a decrease in the effective modulus and an increase in the anelastic strain. The ice exhibited a very complex temperature dependence, a stress dependence that was approximately linear at low temperatures and nonlinear at high temperatures, and a significant frequency effect. RP COLE, DM (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 59 TC 39 Z9 40 U1 0 U2 5 PU TAYLOR & FRANCIS LTD LONDON PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0141-8610 J9 PHILOS MAG A JI Philos. Mag. A-Phys. Condens. Matter Struct. Defect Mech. Prop. PD JUL PY 1995 VL 72 IS 1 BP 209 EP 229 PG 21 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter SC Materials Science; Metallurgy & Metallurgical Engineering; Physics GA RH306 UT WOS:A1995RH30600013 ER PT J AU COLE, DM AF COLE, DM TI A MODEL FOR THE ANELASTIC STRAINING OF SALINE ICE SUBJECTED TO CYCLIC LOADING SO PHILOSOPHICAL MAGAZINE A-PHYSICS OF CONDENSED MATTER STRUCTURE DEFECTS AND MECHANICAL PROPERTIES LA English DT Article ID X-RAY TOPOGRAPHY; INTERNAL-FRICTION; GRAIN-BOUNDARIES; DISLOCATIONS; DEFORMATION; CREEP; FAILURE; SIZE AB This work formulates a model of the anelastic response of saline ice based on dislocation and grain-boundary relaxations. The dislocation-based mechanism generally dominates the behaviour, having a relaxation strength of approximately an order of magnitude greater than the grain-boundary relaxation. The latter process explains the anelasticity observed at higher frequencies and lower temperatures. An expression for the oscillatory motion of basal plane dislocations is developed that derives its temperature dependence from the dislocation drag term, which is found to be approximately the same as in freshwater ice. The results of a frequency shift analysis indicate that the dislocation relaxation may be described by a single activation energy and a distribution in relaxation time. The model applies to the region of behaviour that is approximately linear in stress. Predictions of transient and steady-state cyclic loading behaviour are examined in detail and compared with experimental observations. Aspects of the model that are still under development, related primarily to temperature effects on the microstructure and the incorporation of explicit microstructural parameters, are also discussed. RP COLE, DM (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 45 TC 43 Z9 44 U1 0 U2 5 PU TAYLOR & FRANCIS LTD LONDON PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0141-8610 J9 PHILOS MAG A JI Philos. Mag. A-Phys. Condens. Matter Struct. Defect Mech. Prop. PD JUL PY 1995 VL 72 IS 1 BP 231 EP 248 PG 18 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter SC Materials Science; Metallurgy & Metallurgical Engineering; Physics GA RH306 UT WOS:A1995RH30600014 ER PT J AU SCALORA, M DOWLING, JP MANKA, AS BOWDEN, CM HAUS, JW AF SCALORA, M DOWLING, JP MANKA, AS BOWDEN, CM HAUS, JW TI PULSE-PROPAGATION NEAR HIGHLY REFLECTIVE SURFACES - APPLICATIONS TO PHOTONIC BAND-GAP STRUCTURES AND THE QUESTION OF SUPERLUMINAL TUNNELING TIMES SO PHYSICAL REVIEW A LA English DT Article ID NONLINEAR PERIODIC STRUCTURES; ENVELOPE-FUNCTION APPROACH; TRAVERSAL-TIME; ELECTRODYNAMICS; TRANSVERSE C1 RENSSELAER POLYTECH INST,DEPT PHYS,TROY,NY 12180. RP SCALORA, M (reprint author), USA,MISSILE COMMAND,WEAP SCI DIRECTORATE,AMSMI RD WS ST,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 34 TC 37 Z9 38 U1 1 U2 3 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD JUL PY 1995 VL 52 IS 1 BP 726 EP 734 DI 10.1103/PhysRevA.52.726 PG 9 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA RH932 UT WOS:A1995RH93200089 ER PT J AU DOWLING, JP AF DOWLING, JP TI PARAPSYCHOLOGICAL-REVIEW-A SO PHYSICS TODAY LA English DT Letter RP DOWLING, JP (reprint author), USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 6 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0031-9228 J9 PHYS TODAY JI Phys. Today PD JUL PY 1995 VL 48 IS 7 BP 78 EP 78 DI 10.1063/1.2808112 PG 1 WC Physics, Multidisciplinary SC Physics GA RG350 UT WOS:A1995RG35000021 ER PT J AU KOHLMAN, WG AF KOHLMAN, WG TI BALLISTIC PERFORMANCE OF POLYCARBONATE/POLYESTER AND POLYCARBONATE/STYRENE-ACRYLONITRILE MICROLAYER SHEETS SO POLYMER ENGINEERING AND SCIENCE LA English DT Article ID COMPOSITES AB Extruded microlayer sheets of polycarbonate/polyester (PC/PCTG) and polycarbonate/styrene-acrylonitrile (PC/SAN) were tested for ballistic performance. Composition of the microlayer sheets ranged from 60 to 100 percent polycarbonate. The number of layers in the approximately 3 mm thick sheets ranged from one for the blend control samples to 3713 layers in the PC/PCTG sheets. The normalized ballistic test results showed that some samples performed as well as and slightly better than injection molded polycarbonate samples. The failure mechanism was affected by the composition and the number of layers. Increasing composition of polycarbonate and number of layers decreased the percent of brittle failures. RP KOHLMAN, WG (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 10 TC 4 Z9 4 U1 0 U2 4 PU SOC PLASTICS ENG INC PI BROOKFIELD CENTER PA 14 FAIRFIELD DR, BROOKFIELD CENTER, CT 06804-0403 SN 0032-3888 J9 POLYM ENG SCI JI Polym. Eng. Sci. PD JUL PY 1995 VL 35 IS 14 BP 1191 EP 1195 DI 10.1002/pen.760351410 PG 5 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA RM041 UT WOS:A1995RM04100009 ER PT J AU DENAMOR, AFD TANCO, MAL NG, JCY SALOMON, M AF DENAMOR, AFD TANCO, MAL NG, JCY SALOMON, M TI LITHIUM-CORONAND ELECTROLYTES - THERMODYNAMIC AND ELECTROCHEMICAL ASPECTS SO PURE AND APPLIED CHEMISTRY LA English DT Article; Proceedings Paper CT 2nd International Symposium on Macrocyclic Ligands for the Design of New Materials CY AUG 29-SEP 01, 1994 CL BUENOS AIRES, ARGENTINA SP Int Union Pure & Appl Chem, Coordinating Comm Chem & Adv Mat Programme, European Latin Amer Res Grp Natl Univ S, Argentina, Univ Surrey ID PROPYLENE CARBONATE; ACETONITRILE; CONDUCTANCE; COMPLEXES; SOLVENTS; IONS AB The research strategy for the selection of lithium coronand electrolytes which may be relevant to battery technology is described. Particular emphasis is placed on the solution thermochemical behaviour of lithium and lithium coronand electrolytes in acetonitrile, propylene carbonate and tetrahydrofuran. Enthalpies of coordination referred to reactants and products in their pure physical state are used in combination with corresponding solution data for the host, the guest and the resulting complex to derive for the first time the enthalpies of complexation of lithium and crown ethers in low permittivity media. The implication of thermodynamic studies on the conductance behaviour of lithium and lithium coronand electrolytes in propylene carbonate is quantitatively demonstrated in the limiting molar conductivities of these electrolytes in this solvent. C1 USA,ARL,DIV POWER SOURCES,FT MONMOUTH,NJ 07703. RP DENAMOR, AFD (reprint author), UNIV SURREY,DEPT CHEM,THERMOCHEM LAB,GUILDFORD GU2 5XH,SURREY,ENGLAND. NR 13 TC 12 Z9 12 U1 1 U2 2 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0033-4545 J9 PURE APPL CHEM JI Pure Appl. Chem. PD JUL PY 1995 VL 67 IS 7 BP 1095 EP 1102 DI 10.1351/pac199567071095 PG 8 WC Chemistry, Multidisciplinary SC Chemistry GA RK773 UT WOS:A1995RK77300011 ER PT J AU SHIELS, WE AF SHIELS, WE TI INTRACOLONIC PRESSURE AND ENEMAS IN CHILDREN - FORM FOLLOWS FUNCTION SO RADIOLOGY LA English DT Editorial Material DE BARIUM ENEMA EXAMINATION; BARIUM ENEMA EXAMINATION, IN INFANTS AND CHILDREN; EDITORIALS; INTUSSUSCEPTION ID INTUSSUSCEPTION; AIR C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. RP SHIELS, WE (reprint author), WALTER REED ARMY MED CTR,OFF USA SURG GEN,WASHINGTON,DC 20307, USA. NR 5 TC 1 Z9 2 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD JUL PY 1995 VL 196 IS 1 BP 19 EP 21 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA RE308 UT WOS:A1995RE30800006 PM 7784566 ER PT J AU CHANDNANI, VP GAGLIARDI, JA MURNANE, TG BRADLEY, YC DEBERARDINO, TA SPAETH, J HANSEN, MF AF CHANDNANI, VP GAGLIARDI, JA MURNANE, TG BRADLEY, YC DEBERARDINO, TA SPAETH, J HANSEN, MF TI GLENOHUMERAL LIGAMENTS AND SHOULDER CAPSULAR MECHANISM - EVALUATION WITH MR ARTHROGRAPHY SO RADIOLOGY LA English DT Article DE LIGAMENTS, INJURIES; SHOULDER, ARTHROGRAPHY; SHOULDER, INJURIES; SHOULDER, MR ID CT ARTHROGRAPHY; INSTABILITY; JOINT; COMPLEX; TEARS AB PURPOSE: To evaluate the efficacy of magnetic resonance (MR) arthrography in identification of the glenohumeral ligaments (GHLs) and to determine the location of abnormalities of the GHL, joint capsule, and labrum. MATERIALS AND METHODS: MR arthrograms were evaluated retrospectively in 46 patients with a history of shoulder instability, impingement syndrome, or pain of unknown cause. Imaging findings were correlated with surgical observations. RESULTS: The superior, middle, and inferior GHLs were identified on MR arthrograms in 39 (85%), 39 (85%)I and 42 (91%) of the 46 patients, respectively. In diagnosis of tears of the superior, middle, and inferior GHLs, MR arthrography had a sensitivity of 100%, 89%, and 88% and a specificity of 94%, 88%, and 100%, respectively. CONCLUSION: Findings at MR arthrography can help accurate identification and demonstration of the integrity of the GHL and labrum and can help in staging of abnormalities. The large number of abnormalities depicted in the middle and inferior GHLs suggests that both might be important in the maintenance of glenohumeral joint congruity. C1 TRIPLER ARMY MED CTR,HSHK DR,DEPT ORTHOPED SURG,HONOLULU,HI 96859. UNIV NEW MEXICO,DEPT RADIOL,ALBUQUERQUE,NM. RP CHANDNANI, VP (reprint author), TRIPLER ARMY MED CTR,HSHK DR,DEPT RADIOL,HONOLULU,HI 96859, USA. OI DeBerardino, Thomas/0000-0002-7110-8743 NR 24 TC 105 Z9 108 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD JUL PY 1995 VL 196 IS 1 BP 27 EP 32 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA RE308 UT WOS:A1995RE30800010 PM 7784579 ER PT J AU THORPY, M EINSTEIN, A DERDERIAN, S KADER, G MILLMAN, R ROSEN, G STROLLO, PJ WOOTEN, V AF THORPY, M EINSTEIN, A DERDERIAN, S KADER, G MILLMAN, R ROSEN, G STROLLO, PJ WOOTEN, V TI PRACTICE PARAMETERS FOR THE TREATMENT OF SNORING AND OBSTRUCTIVE SLEEP-APNEA WITH ORAL APPLIANCES SO SLEEP LA English DT Article AB These clinical guidelines, which have been reviewed and approved by the Board of Directors of the American Sleep Disorders Association (ASDA), provide recommendations for the practice of sleep medicine in North America with regards to the use of oral appliances for the treatment of snoring and obstructive sleep apnea. Oral appliances have been developed for the treatment of snoring and have been applied to the treatment of obstructive sleep apnea, a syndrome associated with morbidity. Based on a review of the relevant scientific literature, the Standards of Practice Committee of the ASDA has developed guidelines describing the use of oral appliances for the treatment of snoring and obstructive sleep apnea in adults. C1 MONTEFIORE MED CTR,CTR SLEEP WAKE DISORDERS,BRONX,NY 10467. ALBERT EINSTEIN COLL MED,BRONX,NY 10467. LOUISIANA STATE UNIV,MED CTR,CTR SLEEP DISORDERS,SHREVEPORT,LA 71105. WALTER REED ARMY MED CTR,CTR SLEEP RELATED BREATHING DISORDERS,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. HCA WESLEY NEURODIAGNOST & SLEEP DISORDERS CTR,WICHITA,KS. UNIV KANSAS,SCH MED,LAWRENCE,KS 66045. RHODE ISL HOSP,CTR SLEEP DISORDERS,PROVIDENCE,RI 02902. BROWN UNIV,PROVIDENCE,RI 02912. GEORGETOWN UNIV,CTR SLEEP DISORDERS,WASHINGTON,DC 20057. HENNEPIN CTY MED CTR,MINNEAPOLIS,MN. UNIV MINNESOTA,SCH MED,DEPT PEDIAT,MINNEAPOLIS,MN 55455. PULM SLEEP EVALUAT CTR,PITTSBURGH,PA. UNIV PITTSBURGH,SCH MED,PITTSBURGH,PA 15260. SENTERA NORFOLK GEN HOSP,CTR SLEEP DISORDERS,NORFOLK,VA. EASTERN VIRGINIA MED SCH,NORFOLK,VA 23501. NR 3 TC 137 Z9 142 U1 1 U2 7 PU AMER SLEEP DISORDERS ASSOC PI ROCHESTER PA 1610 14TH STREET NW SUITE 300, ROCHESTER, MN 55806 SN 0161-8105 J9 SLEEP JI Sleep PD JUL PY 1995 VL 18 IS 6 BP 511 EP 513 PG 3 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA RK974 UT WOS:A1995RK97400013 ER PT J AU ZAVADA, JM ZHANG, DH AF ZAVADA, JM ZHANG, DH TI LUMINESCENCE PROPERTIES OF ERBIUM IN III-V COMPOUND SEMICONDUCTORS SO SOLID-STATE ELECTRONICS LA English DT Review ID RARE-EARTH IONS; 1.54 MU-M; DOPED GAAS; FIBER AMPLIFIER; PHASE EPITAXY; SILICON; PHOTOLUMINESCENCE; 1.54-MU-M; TRANSMISSION; FABRICATION AB Optoelectronic materials doped with Er atoms are receiving widespread attentions due to their impact on optical communication systems operating at 1.54 mu m. Optical amplifiers based on Er-doped fibers have demonstrated major improvements in link distance, data rates and reduced needs for signal regeneration. III-V semiconductors doped with Er offer the prospect of very stable, temperature-insensitive, laser diodes emitting at 1.54 mu m. This paper provides a review of the luminescence characteristics of III-V semiconductors doped with Er atoms. Aspects of Er incorporation in the III-V crystal host, photoluminescence properties, and prototype electroluminescent devices are addressed. Details of some of the first observations of photoluminescence of Er atoms in III-V nitride semiconductors, in particular GaN epilayers, are discussed. The GaN epilayers were optically excited using an argon-ion laser and spectra, centered at 1.54 mu m, were observed at 6, 77 and 300 K. The spectra display many of the allowed transitions typical of the Er3+ configuration and are nearly as intense at room temperature as at 77 K. This result indicates that the wide bandgap III-V semiconductors may be ideal host materials for Er-doped electroluminescent devices. C1 N CAROLINA STATE UNIV,RALEIGH,NC 27695. RP ZAVADA, JM (reprint author), USA,RES OFF,RES TRIANGLE PK,NC 27709, USA. NR 48 TC 97 Z9 97 U1 3 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD JUL PY 1995 VL 38 IS 7 BP 1285 EP 1293 DI 10.1016/0038-1101(94)00286-O PG 9 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA RD579 UT WOS:A1995RD57900001 ER PT J AU WILSON, RG VARTULI, CB ABERNATHY, CR PEARTON, SJ ZAVADA, JM AF WILSON, RG VARTULI, CB ABERNATHY, CR PEARTON, SJ ZAVADA, JM TI IMPLANTATION AND REDISTRIBUTION OF DOPANTS AND ISOLATION SPECIES IN GAN AND RELATED-COMPOUNDS SO SOLID-STATE ELECTRONICS LA English DT Article ID III-V-MATERIALS; GROWTH AB Twelve different elements used for doping or isolation were implanted into GaN (and selected species into AIN and InN), and the resulting range parameters were measured by secondary ion mass spectrometry. For lighter elements such as Be, F and H, the agreement between experimental range and range straggle determined using a Pearson IV computer fitting routine and those predicted by TRIM 92 calculations was good, but for heavier elements such as Ge and Se, the discrepancy can be as much as a factor of two in range. There was little redistribution of any of the investigated species up to 700 degrees C, except for H-2 in AIN and S in GaN. Elements such as F and Be, which are generally rapid diffusers in III-V compounds, do not display any redistribution in GaPZ for temperatures up to 800 degrees C. C1 UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP WILSON, RG (reprint author), HUGHES RES LABS,MALIBU,CA 90265, USA. NR 23 TC 29 Z9 29 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD JUL PY 1995 VL 38 IS 7 BP 1329 EP 1333 DI 10.1016/0038-1101(94)00251-A PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA RD579 UT WOS:A1995RD57900008 ER PT J AU MORRIS, MJ PEACOCK, MD LLOYD, WC JOHNSON, JE AF MORRIS, MJ PEACOCK, MD LLOYD, WC JOHNSON, JE TI RECURRENT BILATERAL SPONTANEOUS PNEUMOTHORACES ASSOCIATED WITH PULMONARY ANGIOCENTRIC IMMUNOPROLIFERATIVE LESION SO SOUTHERN MEDICAL JOURNAL LA English DT Note ID LYMPHOMATOID GRANULOMATOSIS; SPECTRUM AB A 28-year-old man had a left pneumothorax and diffuse reticulonodular infiltrates. He subsequently had a right pneumothorax and manifested bilateral recurrences after treatment of the initial pneumothoraces. Pulmonary angiocentric immunoproliferative lesion was diagnosed by open lung biopsy. Treatment with combination chemotherapy improved the infiltrates, but failed to prevent another pneumothorax. Etiologic considerations for the recurrent pneumothoraces are proposed. C1 BROOKE ARMY MED CTR,AREA LAB SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234. USA,BROOKE ARMY MED CTR,DEPT MED,PULM DIS CRIT CARE SERV,FT SAM HOUSTON,TX 78234. NR 18 TC 2 Z9 2 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD JUL PY 1995 VL 88 IS 7 BP 771 EP 775 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA RH029 UT WOS:A1995RH02900018 PM 7597487 ER PT J AU JATOI, I BAUM, M AF JATOI, I BAUM, M TI MAMMOGRAPHICALLY DETECTED DUCTAL CARCINOMA IN-SITU - ARE WE OVERDIAGNOSING BREAST-CANCER SO SURGERY LA English DT Editorial Material ID INTRADUCTAL CARCINOMA; INSITU; LUMPECTOMY; WOMEN C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. ROYAL MARSDEN HOSP,LONDON SW3 6JJ,ENGLAND. RP JATOI, I (reprint author), BROOKE ARMY MED CTR,DEPT SURG,2450 STANLEY RD,FT SAM HOUSTON,TX 78234, USA. NR 19 TC 28 Z9 28 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0039-6060 J9 SURGERY JI Surgery PD JUL PY 1995 VL 118 IS 1 BP 118 EP 120 DI 10.1016/S0039-6060(05)80019-4 PG 3 WC Surgery SC Surgery GA RH038 UT WOS:A1995RH03800018 PM 7604373 ER PT J AU Kinkead, ER Wolfe, RE Flemming, CD Leahy, HF Caldwell, DJ Miller, CR Marit, GB AF Kinkead, ER Wolfe, RE Flemming, CD Leahy, HF Caldwell, DJ Miller, CR Marit, GB TI Reproductive toxicity screen of ammonium dinitramide administered in the drinking water of Sprague-Dawley rats SO TOXICOLOGY AND INDUSTRIAL HEALTH LA English DT Article DE ammonium dinitramide; explosives; methemoglobinemia; nitrate; reproductive screen ID 1,3-DINITROBENZENE; TRINITROTOLUENE AB The Department of Defense is currently considering replacing ammonium perchlorate with ammonium dinitramide (ADN), a class 1.1 explosive oxidizer to be used in solid rocket propellant mixtures and explosives. This study was intended to evaluate the potential of ADN to produce alterations in paternal fertility, maternal pregnancy and lactation, and growth and development of offspring. Male and female rats received drinking water containing 0.0, 0.2, 1.0, or 2.0 g ADN/liter throughout the study. Mating occurred following 14 days of treatment. All darns, one-half the males, and representative pups were maintained for a total of 90 days of treatment. No mortality occurred in parental animals during the study. Treatment with ADN resulted in no adverse effects on mating; 92-100% of the animals mated No treatment-related effects were seen in parental animals clinically or histopathologically. Adverse treatment-related effects were noted in maternal and paternal fertility indices, gestational indices, and live birth indices in both the mid- and high-dose groups. Litter sizes in the mid- and high-dose groups were significantly smaller than those of the low-dose and control groups. Mean pup weights showed no statistically significant differences between ADN-treated pups and controls. Gross and histopathological examination of the animals failed to identify the cause for the decrease in litter production in the mid- and high-dose dams. This study indicates that ADN is a reproductive toxicant. The no-observable-effect level (NOEL) is 29 mg/kg/day, the median dose of the low-level female rats. C1 USA,WALTER REED ARMY INST RES,MED RES DETACHMENT,WRIGHT PATTERSON AFB,OH. ARMSTRONG LAB,DIV TOXICOL,OCCUPAT & ENVIRONM HLTH DIRECTORATE,WRIGHT PATTERSON AFB,OH. RP Kinkead, ER (reprint author), MANTECH ENVIRONM TECHNOL INC,POB 31009,DAYTON,OH 45437, USA. NR 21 TC 3 Z9 3 U1 0 U2 2 PU PRINCETON SCIENTIFIC PUBL INC PI PRINCETON PA PO BOX 2155, PRINCETON, NJ 08543 SN 0748-2337 J9 TOXICOL IND HEALTH JI Toxicol. Ind. Health PD JUL-AUG PY 1995 VL 11 IS 4 BP 437 EP 448 PG 12 WC Public, Environmental & Occupational Health; Toxicology SC Public, Environmental & Occupational Health; Toxicology GA TK629 UT WOS:A1995TK62900006 PM 8748424 ER PT J AU LESKOVAC, V TRIVIC, S PEGGINS, JO AF LESKOVAC, V TRIVIC, S PEGGINS, JO TI PRIMARY TOXIC EFFECTS OF ANTHRAQUINONE-2-SULFONIC ACID IN RAT-LIVER MICROSOMES SO TOXICOLOGY LETTERS LA English DT Article DE RAT LIVER MICROSOMES; ANTHRAQUINONE-2-SULFONIC ACID; HYDROGEN PEROXIDE; SUPEROXIDE ANION RADICALS ID HEPATIC-METABOLISM; ARTEMISININ DRUGS AB (1) The endogenous, NADPH-supported production of H2O2 and of O-2-radical-anion-radicals in rat liver microsomes was very strongly enhanced in the presence of anthraquinone-2-sulfonic acid (AQSA). (2) This induction of H2O2 and of O-2-radical-anion-radicals was catalyzed by the microsomal NADPH:cytochrome P450 oxidoreductase (EC 1.6.2.4). (3) AQSA was reduced to AQSA radicals by reductase; AQSA radicals reduce molecular oxygen to O-2-radical-anion-radicals, which are readily dismutated to H2O2 by the microsomal superoxide dismutase. (4) O-2-radical-anion-radicals are the sole precursors of all AQSA-induced production of H2O2 in liver microsomes. C1 FAC SCI NOVI SAD, INST PHYS, YU-21000 NOVI SAD, YUGOSLAVIA. WALTER REED ARMY MED CTR, RES INST, WASHINGTON, DC 20307 USA. RP UNIV NOVI SAD, FAC TECHNOL, YU-21000 NOVI SAD, YUGOSLAVIA. NR 11 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 EI 1879-3169 J9 TOXICOL LETT JI Toxicol. Lett. PD JUL PY 1995 VL 78 IS 2 BP 107 EP 110 DI 10.1016/0378-4274(94)03238-3 PG 4 WC Toxicology SC Toxicology GA RG912 UT WOS:A1995RG91200004 PM 7618176 ER PT J AU LANCE, R ALBO, M COSTABILE, RA STEERS, WD AF LANCE, R ALBO, M COSTABILE, RA STEERS, WD TI ORAL TRAZODONE AS EMPIRICAL THERAPY FOR ERECTILE DYSFUNCTION - A RETROSPECTIVE REVIEW SO UROLOGY LA English DT Article ID IMPOTENCE; PRIAPISM; DRUGS AB Objectives, Anecdotal reports of increased libido and sexual function in patients taking trazodone have led to its empirical use in patients with erectile dysfunction. A retrospective review of patient-reported responses to trazodone was performed to outline the efficacy and side-effect profile of this agent. Methods. Between 1989 and 1994, 182 patients were placed on oral trazodone as empirical therapy for erectile dysfunction. Patients ranged in age from 26 to 85 years, with a mean of 60 years. Patients were evaluated before receiving trazodone with a thorough medical history and physical examination. Known risk factors for erectile dysfunction were assigned based on historical information and the findings of the examination. Patients received trazodone for at least 2 consecutive months, with daily doses starting at 25 mg. Results. One hundred twenty-seven patients were available for follow-up by a standardized questionnaire regarding perceived improvement in erectile function, sexual function, and side effects. In patients less than 60 years of age, with no known risk factors for erectile dysfunction, 21 of 27 (78%) showed significant improvement in erectile ability, Smokers and patients older than 60 years with a history of significant peripheral vascular disease responded poorly to trazodone therapy. The duration of erectile dysfunction was inversely related to a response to trazodone. Of patients with a duration of impotence less than 12 months, 48% reported a positive response. Only 16% of patients with duration of erectile dysfunction greater than 60 months reported improvement in erections and sexual function. Trazodone was well tolerated by this population, with 62% reporting no side effects. Conclusions. Despite the limitations of a nonrandomized, retrospective study, trazodone appears to benefit younger patients with erectile dysfunction with few known risk factors. A prospective, placebo-controlled trial is needed to confirm the observations of this pilot study. C1 WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307. UNIV VIRGINIA,HLTH SCI CTR,DEPT UROL,CHARLOTTESVILLE,VA. NR 15 TC 34 Z9 34 U1 0 U2 3 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD JUL PY 1995 VL 46 IS 1 BP 117 EP 120 DI 10.1016/S0090-4295(99)80176-9 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA RG401 UT WOS:A1995RG40100031 PM 7604472 ER PT J AU YEE, LL COHEN, AJ VERNALIS, MN LOVETT, EJ CROWL, FD AF YEE, LL COHEN, AJ VERNALIS, MN LOVETT, EJ CROWL, FD TI DIAGNOSIS OF ATRIAL BAFFLE OBSTRUCTION FOLLOWING SENNING REPAIR BY INTRAOPERATIVE TRANSESOPHAGEAL ECHOCARDIOGRAPHY - A CASE-REPORT SO VASCULAR SURGERY LA English DT Note AB Intraoperative transesophageal echocardiography identified the site of pulmonary venous obstruction and assessed the adequacy of surgical repair in a patient scheduled for revision of a Senning repair. Preoperatively, this abnormality was not clearly delineated by other imaging modalities. C1 WALTER REED ARMY MED CTR,ANESTHESIA SERV,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WESTMINSTER PUBL INC PI GLEN HEAD PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 SN 0042-2835 J9 VASCULAR SURG JI Vasc. Surg. PD JUL-AUG PY 1995 VL 29 IS 4 BP 293 EP 297 DI 10.1177/153857449502900406 PG 5 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA RH378 UT WOS:A1995RH37800006 ER PT J AU CELEMIN, C RUBIO, P ECHEVERRIA, P SUAREZ, S AF CELEMIN, C RUBIO, P ECHEVERRIA, P SUAREZ, S TI GENE TOXIN PATTERNS OF ESCHERICHIA-COLI ISOLATED FROM DISEASED AND HEALTHY PIGLETS SO VETERINARY MICROBIOLOGY LA English DT Article DE ENTEROTOXINS; GENETIC PROBES; E. COLI; PORCINE DIARRHEA ID LABILE ENTERO-TOXIN; ACTIVATES ADENYLATE-CYCLASE; HEAT-STABLE ENTEROTOXIN; SHIGA-LIKE TOXINS; COLONY HYBRIDIZATION; INFANT MICE; DNA PROBES; DIARRHEA; PIGS; CLONING AB DNA probes specific for genes coding for the heat stable enterotoxins (ST-I and ST-IT), the heat labile enterotoxins (LT-I and LT-II), Shiga like cytotoxins and for the enterohemorrhagic factor (EHF), were used to examine 150 fecal Escherichia coli isolates from both diarrheic and healthy piglets. Thirty seven percent of the isolates hybridized with the LT-I probe, seventy one of them did so with the LT-II probe, while seventy six percent of the isolates possessed genes coding for the heat stable enterotoxins. No SLT-I positive hybridization was found and four percent of the isolates possessed SLT-II genes. C1 UNIV LEON,FAC VET,DEPT SANIDAD ANIM,E-24071 LEON,SPAIN. ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. NR 34 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1135 J9 VET MICROBIOL JI Vet. Microbiol. PD JUL PY 1995 VL 45 IS 2-3 BP 121 EP 127 DI 10.1016/0378-1135(94)00129-K PG 7 WC Microbiology; Veterinary Sciences SC Microbiology; Veterinary Sciences GA RM170 UT WOS:A1995RM17000002 PM 7571363 ER PT J AU POINDEXTER, EH AF POINDEXTER, EH TI PHYSICAL-CHEMISTRY OF HYDROGENOUS SPECIES IN THE SI-SIO2 SYSTEM SO ZEITSCHRIFT FUR NATURFORSCHUNG SECTION A-A JOURNAL OF PHYSICAL SCIENCES LA English DT Article ID ELECTRON-PARAMAGNETIC-RES; ATOMIC-HYDROGEN; PB CENTERS; MOLECULAR-HYDROGEN; INTERFACE STATES; ALPHA-QUARTZ; SILICON; KINETICS; DEFECTS; DIFFUSION AB Research on hydrogenous species in the Si-SiO2 system is reviewed and examined. Some aspects of thermal silica on silicon are explained by comparison with crystalline quartz or bulk amorphous fused silica. Hydrogen behavior in the Si-SiO, system is complicated by the unique features of device processing technology, an electrified interface, and high electric fields. An electrochemical model of the negative-bias-field-induced degradation of the system is used as a starting point for discussion of diffusion and solubility, atomic H disposition, thermochemical phenomena, and radiation damage. It is thereby hoped to provide new approaches for complete modeling of hydrogen physical chemistry in the Si-SiO2 system. RP POINDEXTER, EH (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 50 TC 12 Z9 12 U1 0 U2 4 PU VERLAG Z NATURFORSCH PI TUBINGEN PA POSTFACH 2645, W-7400 TUBINGEN, GERMANY SN 0932-0784 J9 Z NATURFORSCH A JI Z. Naturfors. Sect. A-J. Phys. Sci. PD JUL PY 1995 VL 50 IS 7 BP 653 EP 665 PG 13 WC Chemistry, Physical; Physics, Multidisciplinary SC Chemistry; Physics GA RL294 UT WOS:A1995RL29400005 ER PT J AU SADDOW, SE LANG, M DALIBOR, T PENSL, G NEUDECK, PG AF SADDOW, SE LANG, M DALIBOR, T PENSL, G NEUDECK, PG TI THERMAL CAPACITANCE SPECTROSCOPY OF EPITAXIAL 3C AND 6H-SIC PN JUNCTION DIODES GROWN SIDE-BY-SIDE ON A GH-SIC SUBSTRATE SO APPLIED PHYSICS LETTERS LA English DT Article ID CARBIDE; CENTERS C1 UNIV ERLANGEN NURNBERG, INST ANGEW PHYS, D-91058 ERLANGEN, GERMANY. NASA, LEWIS RES CTR, CLEVELAND, OH 44135 USA. RP SADDOW, SE (reprint author), USA, RES LAB, WEAPONS TECHNOL DIRECTORATE, ADELPHI, MD 20783 USA. NR 16 TC 9 Z9 9 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 26 PY 1995 VL 66 IS 26 BP 3612 EP 3614 DI 10.1063/1.113804 PG 3 WC Physics, Applied SC Physics GA RE742 UT WOS:A1995RE74200024 ER PT J AU MADUH, EU NEALLEY, EW SONG, HF WANG, PC BASKIN, SI AF MADUH, EU NEALLEY, EW SONG, HF WANG, PC BASKIN, SI TI A PROTEIN-KINASE-C INHIBITOR ATTENUATES CYANIDE TOXICITY IN-VIVO SO TOXICOLOGY LA English DT Article DE PROTEIN KINASE C; PKC INHIBITORS; HYPOXIA; PIPERAZINES; CYANIDE ANTIDOTES; MEDIATORS ID PERSPECTIVES; ANTAGONISM; ISCHEMIA AB We have examined the effect of pretreatment with a potent protein kinase C (PKC) inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), against metabolic alterations induced by sodium cyanide (NaCN), 4.2 mg/kg, in brain of anesthetized male micropigs(R) (6-10 kg). Brain high energy phosphates were analyzed using a P-31 nuclear magnetic resonance (NMR) spectroscopic surface coil in a 4.7 Tesla horizontal bore magnet. H-7, 1 mg/kg, was given intravenously (i.v.) 30 min before NaCN challenge (H-7 + CN-). Prior to NaCN, H-7, or H-7 + CN- administration, baseline P-31 resonance spectra of 1-min duration were acquired for 5-10 min, and continued for an additional 60 min following i.v. NaCN injection, each animal serving as its own control. Peaks were identified as phosphomonoester (PME), inorganic phosphate (Pi), phosphodiester (PDE), phosphocreatine (PCr) and adenosine triphosphate (ATP), based on their respective chemical shifts. Without H-7 pretreatment, NaCN effects were marked by a rising Pi and a declining PCr peak 2 min after injection,;with only 2/5 of the animals surviving the 60 min experiment. Through a pretreatment period of 30 min, H-7 did not affect baseline cell energy profile as reflected by the P-31-NMR spectra, but in its presence, those changes (i.e. diminishing PCr and rising Pi peaks) elicited by NaCN were markedly blunted; 4/5 of the animals in this group survived the NaCN challenge. It is proposed that H-7, a pharmacologic inhibitor of PKC, may be useful in CN- antagonism, underscoring the role of PKC in cyanide intoxication. C1 USA,MED RES INST CHEM DEF,MCMR,UV,PB,DIV PHARMACOL,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. HOWARD UNIV,WASHINGTON,DC 20059. NR 32 TC 2 Z9 3 U1 0 U2 0 PU ELSEVIER SCI PUBL IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD JUN 26 PY 1995 VL 100 IS 1-3 BP 129 EP 137 DI 10.1016/0300-483X(95)03078-T PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA RL223 UT WOS:A1995RL22300014 PM 7624870 ER PT J AU DALSGAARD, A NIELSEN, GL ECHEVERRIA, P LARSEN, JL SCHONHEYDER, HC AF DALSGAARD, A NIELSEN, GL ECHEVERRIA, P LARSEN, JL SCHONHEYDER, HC TI VIBRIO-CHOLERAE O139 IN DENMARK SO LANCET LA English DT Letter C1 AALBORG HOSP,DEPT GASTROENTEROL,AALBORG,DENMARK. ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. AALBORG HOSP,DEPT CLIN MICROBIOL,AALBORG,DENMARK. RP DALSGAARD, A (reprint author), ROYAL VET & AGR UNIV,DEPT VET MICROBIOL,FISH DIS LAB,DK-1870 FREDERIKSBERG C,DENMARK. NR 5 TC 8 Z9 9 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0099-5355 J9 LANCET JI Lancet PD JUN 24 PY 1995 VL 345 IS 8965 BP 1637 EP 1638 DI 10.1016/S0140-6736(95)90142-6 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA RE670 UT WOS:A1995RE67000039 PM 7783553 ER PT J AU LAMIELL, JM AF LAMIELL, JM TI HEALTH AND DRUG INFORMATION LIBRARY SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Software Review RP LAMIELL, JM (reprint author), USA,AMEDD CTR & SCH,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUN 21 PY 1995 VL 273 IS 23 BP 1883 EP 1883 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA RD116 UT WOS:A1995RD11600035 ER PT J AU WHITTEN, WB SHAPIRO, MJ RAMSEY, JM BRONK, BV AF WHITTEN, WB SHAPIRO, MJ RAMSEY, JM BRONK, BV TI MORPHOLOGICAL RESONANCES FOR MULTICOMPONENT IMMUNOASSAYS SO APPLIED OPTICS LA English DT Article ID DIELECTRIC SPHERES; LIGHT-SCATTERING; MICROSPHERES; PARTICLES; ALGORITHM; PRECISION; SPECTRA AB An immunoassay technique capable of detecting and identifying a number of species of microorganisms in a single analysis is described. The method uses optical-resonance size discrimination of microspheres to identify antibodies to which stained microorganisms are bound. C1 USA,CTR DEV & ENGN,EDGEWOOD,MD 21010. RP WHITTEN, WB (reprint author), OAK RIDGE NATL LAB,DIV CHEM & ANALYT SCI,OAK RIDGE,TN 37831, USA. NR 25 TC 11 Z9 11 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUN 20 PY 1995 VL 34 IS 18 BP 3203 EP 3207 PG 5 WC Optics SC Optics GA RC496 UT WOS:A1995RC49600002 PM 21052124 ER PT J AU MCNESBY, KL DANIEL, RG MORRIS, JB MIZIOLEK, AW AF MCNESBY, KL DANIEL, RG MORRIS, JB MIZIOLEK, AW TI TOMOGRAPHIC ANALYSIS OF CO ABSORPTION IN A LOW-PRESSURE FLAME SO APPLIED OPTICS LA English DT Article DE TUNABLE DIODE LASER; TEMPERATURE MEASUREMENT; 2-LINE THERMOMETRY; ABSORPTION SPECTROSCOPY ID DIODE-LASER; TEMPERATURE; ABEL AB Tomographic analysis is used to provide a correction to low-pressure stoichiometric premixed CH4/O-2 flame temperatures measured with tunable diode laser absorption spectroscopy employing CO two-line thermometry. It is shown that flame temperatures measured with line-of-sight-based two-line thermometry are always too low and that the correction to the observed temperature is a nonlinear function of the height above the burner surface. It is also shown that, at a given height in the flame, a constant temperature across the flame does not imply that vibrational populations are constant and that, at low pressures (<20 Torr), the flame spreads radially beyond the burner diameter and so may no longer be approximated by a one-dimensional model. RP MCNESBY, KL (reprint author), USA, RES LAB, ABERDEEN PROVING GROUND, MD 21005 USA. NR 19 TC 12 Z9 12 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUN 20 PY 1995 VL 34 IS 18 BP 3318 EP 3324 PG 7 WC Optics SC Optics GA RC496 UT WOS:A1995RC49600016 PM 21052138 ER PT J AU BUCKHEIT, RW FLIAKASBOLTZ, V YEAGYBARGO, S WEISLOW, O MAYERS, DL BOYER, PL HUGHES, SH PAN, BC CHU, SH BADER, JP AF BUCKHEIT, RW FLIAKASBOLTZ, V YEAGYBARGO, S WEISLOW, O MAYERS, DL BOYER, PL HUGHES, SH PAN, BC CHU, SH BADER, JP TI RESISTANCE TO 1-[(2-HYDROXYETHOXY)METHYL]-6-(PHENYLTHIO)THYMINE DERIVATIVES IS GENERATED BY MUTATIONS AT MULTIPLE SITES IN THE HIV-1 REVERSE-TRANSCRIPTASE SO VIROLOGY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; NONNUCLEOSIDE INHIBITORS; HIV-1-SPECIFIC INHIBITORS; ANTIVIRAL ACTIVITY; TIBO DERIVATIVES; VIRAL RESISTANCE; DRUG; REPLICATION; SENSITIVITY; NEVIRAPINE AB Virus isolates resistant to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) and a highly potent HEPT derivative, [1-benzyloxymethyl-5-ethyl-6-(alpha-pyridylthio)uracil] (NSC 648400, E-BPTU), were selected in cell culture. Cross-resistance evaluation indicated that the two drug-resistant virus isolates were phenotypically distinct from one another although each of the virus isolates was resistant to both of the HEPT derivatives. The virus isolate resistant to NSC 648400 had a single amino acid change in the reverse transcriptase (Y181C) which resulted in cross-resistance to all of the nonnucleoside reverse transcriptase inhibitors evaluated, with the exception of calanolide A. The NSC 648400-resistant virus isolate exhibited 15-fold enhanced sensitivity to calanolide A. The virus isolate selected in the presence of HEPT exhibited a single amino acid change (P236L) which was not cross-resistant to other nonnucleoside RT inhibitors tested with the exception of the two HEPT derivatives. This HEPT-resistant virus isolate exhibited enhanced sensitivity (5- to 10-fold) to thiazolobenzimidazole. We have used both virus isolates with defined single amino acid changes in the RT and bacterially expressed RTs with site-directed amino acid substitutions to test the effects of a wide variety of mutations on the activity of NSC 648400. Single mutations at amino acids 101, 103, 106, 181, or 236 yielded virus with high resistance (> 20)-fold) to NSC 648400, while lower levels of resistance were seen with mutations at amino acids 98, 100, or 108. These results suggest that several changes in the conformation of the nonnucleoside inhibitor binding site of the HIV-1 reverse transcriptase can affect the inhibitory activity of the HEPT class of compounds. (C) 1995 academic Press, Inc. C1 SPA TECHNOL INC,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DEPT HIV DIS PREVENT,ROCKVILLE,MD 20850. NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,FREDERICK,MD 21702. BROWN UNIV,DIV BIOL & MED,PROVIDENCE,RI 02912. NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,ANTIVIRAL EVALUAT BRANCH,BETHESDA,MD 20892. RP BUCKHEIT, RW (reprint author), SO RES INST,FREDERICK RES CTR,VIROL RES GRP,431 AVIAT WAY,FREDERICK,MD 21701, USA. FU NCI NIH HHS [N01-CM-37818, CA 39427]; NIAID NIH HHS [N01-AI-05087] NR 40 TC 33 Z9 35 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD JUN 20 PY 1995 VL 210 IS 1 BP 186 EP 193 DI 10.1006/viro.1995.1330 PG 8 WC Virology SC Virology GA RE655 UT WOS:A1995RE65500020 PM 7540784 ER PT J AU SCOFIELD, RH KURIEN, B GROSS, T WARREN, WL HARLEY, JB AF SCOFIELD, RH KURIEN, B GROSS, T WARREN, WL HARLEY, JB TI HLA-B27 BINDING OF PEPTIDE FROM ITS OWN SEQUENCE AND SIMILAR PEPTIDES FROM BACTERIA - IMPLICATIONS FOR SPONDYLOARTHROPATHIES SO LANCET LA English DT Note ID ANKYLOSING-SPONDYLITIS; REACTIVE ARTHRITIS; MOLECULAR MIMICRY; B27 AB The spondyloarthropathies are associated by an unknown mechanism with HLA-B27 and certain bacteria. HLA-B27 shares sequence with proteins from enteric bacteria. The B*2705 sequence contains a nonapeptide, LRRYLENGK, predicted to bind in the binding cleft of B27. Some nonapeptides from enteric organisms that share sequence with this nonapeptide of B27 also bind B27. These observations suggest an unappreciated mechanism for autoimmunity that may operate in the B27-associated spondyloarthropathies involving peptides bound to and derived from histocompatibility alleles. C1 UNIV OKLAHOMA,HLTH SCI CTR,COLL MED,DEPT MED,OKLAHOMA CITY,OK. USA,DEPT VET AFFAIRS MED CTR,OKLAHOMA CITY,OK. RP SCOFIELD, RH (reprint author), OKLAHOMA MED RES FDN,ARTHRITIS & IMMUNOL PROGRAM,825 NE 13TH ST,OKLAHOMA CITY,OK 73104, USA. RI Kurien, Biji/C-2392-2008 NR 10 TC 76 Z9 77 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0099-5355 J9 LANCET JI Lancet PD JUN 17 PY 1995 VL 345 IS 8964 BP 1542 EP 1544 DI 10.1016/S0140-6736(95)91089-1 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA RD790 UT WOS:A1995RD79000011 PM 7791441 ER PT J AU MAZUMDER, MM SCHASCHEK, K CHANG, RK GILLESPIE, JB AF MAZUMDER, MM SCHASCHEK, K CHANG, RK GILLESPIE, JB TI EFFICIENT PUMPING OF MINORITY SPECIES STIMULATED RAMAN-SCATTERING (SRS) BY MAJORITY SPECIES SRS IN A MICRODROPLET OF A BINARY MIXTURE SO CHEMICAL PHYSICS LETTERS LA English DT Article ID MICROMETER-SIZED DROPLETS; EMISSION AB We have observed that in a binary mixture microdroplet, stimulated Raman scattering (SRS) from the highest-gain mode of the majority species pumps the SRS from the minority species and a weaker-gain mode of the majority species more efficiently than does the input laser. The spatial overlap between the pumping field and the SRS field is an important factor in determining the pumping efficiency. We have numerically studied the effect of spatial overlap. Qualitative discussions are made of the effects of some other factors, such as concentration and Raman gain of the majority species. C1 YALE UNIV,CTR LASER DIAGNOST,NEW HAVEN,CT 06520. USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP MAZUMDER, MM (reprint author), YALE UNIV,DEPT APPL PHYS,POB 208284,NEW HAVEN,CT 06520, USA. NR 16 TC 16 Z9 16 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD JUN 16 PY 1995 VL 239 IS 4-6 BP 361 EP 368 PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA RE253 UT WOS:A1995RE25300026 ER PT J AU BARTH, J AF BARTH, J TI DILLON,CLARENCE - A WALL-STREET ENIGMA - A STUDY IN CONFLICTING MOTIVES - PEREZ,RC, WILLETT,EF SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD JUN 15 PY 1995 VL 120 IS 11 BP 80 EP 80 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA RC370 UT WOS:A1995RC37000110 ER PT J AU ARECCHI, FT LARICHEV, AV RAMAZZA, PL RESIDORI, S RICKLIN, JC VORONTSOV, MA AF ARECCHI, FT LARICHEV, AV RAMAZZA, PL RESIDORI, S RICKLIN, JC VORONTSOV, MA TI EXPERIMENTAL-OBSERVATION OF SPACE-TIME CHAOS IN A NONLINEAR-OPTICAL SYSTEM WITH 2D FEEDBACK SO OPTICS COMMUNICATIONS LA English DT Note ID TURBULENCE AB We report the emergence of a space-time disordered dynamical regime from a regular, patterned state in a system formed by a Liquid Crystal Light Valve (LCLV) with nonlocal feedback. This is obtained for increasing the amplitude of the supply voltage applied to the LCLV, thus inducing a strengthening in the nonlinear coupling between light and matter in this device. Evidence of loss of correlation of the signal is given both in the temporal and in the spatial domain. A comparison is drawn with turbulence in hydrodynamics. C1 USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002. NEW MEXICO STATE UNIV,LAS CRUCES,NM 88003. MOSCOW MV LOMONOSOV STATE UNIV,CTR INT LASER,MOSCOW 119899,RUSSIA. RP ARECCHI, FT (reprint author), IST NAZL OTTICA,I-50125 FLORENCE,ITALY. RI Larichev, Andrey/J-1514-2012 NR 12 TC 14 Z9 14 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD JUN 15 PY 1995 VL 117 IS 5-6 BP 492 EP 496 DI 10.1016/0030-4018(95)00136-V PG 5 WC Optics SC Optics GA RE542 UT WOS:A1995RE54200018 ER PT J AU YIN, SZ LU, MZ CHEN, CL YU, FTS HUDSON, TD MCMILLEN, DK AF YIN, SZ LU, MZ CHEN, CL YU, FTS HUDSON, TD MCMILLEN, DK TI DESIGN OF A BIPOLAR COMPOSITE FILTER BY A SIMULATED ANNEALING ALGORITHM SO OPTICS LETTERS LA English DT Article ID BINARY PHASE AB We present the design of a bipolar composite filter (BCF) by a simulated annealing algorithm. By minimizing the energy function of the system, we construct an out-of-plane rotation-invariant bipolar filter. We show that the BCF offers high pattern discrimination capability and can easily be implemented with an electronically addressed spatial Light modulator. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP YIN, SZ (reprint author), PENN STATE UNIV,DEPT ELECT ENGN,UNIVERSITY PK,PA 16802, USA. NR 11 TC 17 Z9 19 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD JUN 15 PY 1995 VL 20 IS 12 BP 1409 EP 1411 DI 10.1364/OL.20.001409 PG 3 WC Optics SC Optics GA RD232 UT WOS:A1995RD23200020 PM 19862031 ER PT J AU GAMMON, D RUDIN, S REINECKE, TL KATZER, DS KYONO, CS AF GAMMON, D RUDIN, S REINECKE, TL KATZER, DS KYONO, CS TI PHONON BROADENING OF EXCITONS IN GAAS/ALXGA1-XAS QUANTUM-WELLS SO PHYSICAL REVIEW B LA English DT Article ID SIZE DEPENDENCE; LINEWIDTHS; GAAS; SINGLE; ABSORPTION; INTERFACES; RESONANCE; SPECTRA C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP GAMMON, D (reprint author), USN,RES LAB,WASHINGTON,DC 20375, USA. RI Katzer, D. Scott/N-7841-2013 NR 25 TC 83 Z9 83 U1 0 U2 3 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD JUN 15 PY 1995 VL 51 IS 23 BP 16785 EP 16789 DI 10.1103/PhysRevB.51.16785 PG 5 WC Physics, Condensed Matter SC Physics GA RF570 UT WOS:A1995RF57000032 ER PT J AU VANCOTT, TC VEIT, SCD KALYANARAMAN, V EARL, P BIRX, DL AF VANCOTT, TC VEIT, SCD KALYANARAMAN, V EARL, P BIRX, DL TI CHARACTERIZATION OF A SOLUBLE, OLIGOMERIC HIV-1 GP160 PROTEIN AS A POTENTIAL IMMUNOGEN SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE HIV-1 VACCINE; HIV-1 ENVELOPE GLYCOPROTEIN; GP120/GP160; BIACORE; HIV-1 IMMUNE RESPONSE; OLIGOMERIC GP160 ID HUMAN-IMMUNODEFICIENCY-VIRUS; NEUTRALIZING MONOCLONAL-ANTIBODIES; BIOSPECIFIC INTERACTION ANALYSIS; TYPE-1 ENVELOPE GLYCOPROTEIN; GP120; AIDS; ANTIGEN; VACCINE; BINDING; DOMAIN AB We have assessed the oligomeric structure and antigenic properties of an affinity purified gp160 protein (oligo-gp160) using biosensor technology. Sucrose gradient purification analysis identified the existence of tetrameric, dimeric and monomeric forms of the protein. Reactivity to a broad panel of monoclonal antibodies specific for oligomeric gp160, discontinuous epitopes within monomeric gp120 and several linear epitopes within gp120 (V3) and gp41 was demonstrated. International sera from several countries, where HIV-1 clades A-F are prevalent, including type O from Cameroon, were reactive with oligo-gp160 indicating conserved antigenic epitopes. Enhanced immunologic reactivity per gp160 molecule was obtained with oligo-gp160 as compared to other current HIV-1(IIIB) subunit monomeric envelope gp120/gp160 immunogens suggesting higher HIV-1 envelope protein mimicry. HIV-1 antibodies from sera during acute HIV-1 infection were detectable by oligo-gp160 prior to detection with either a recombinant, monomeric gp120 protein or several commercial HIV-1 screening kits suggesting antibodies sensitive to oligomeric gp160 structure may be present earlier in infection. The oligomeric nature of this gp160 protein preparation and high reactivity with divergent mAbs and HIV-1 sera support the use of this protein as an HIV-1 immunogen. C1 HENRY M JACKSON FDN,ROCKVILLE,MD 20850. ADV BIOSCI LABS,KENSINGTON,MD. NIAID,VIRAL DIS LAB,BETHESDA,MD 20892. RP VANCOTT, TC (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,DEPT RETROVIRAL RES,13 TAFT CT,SUITE 200,ROCKVILLE,MD 20850, USA. NR 58 TC 40 Z9 41 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD JUN 14 PY 1995 VL 183 IS 1 BP 103 EP 117 DI 10.1016/0022-1759(95)00038-C PG 15 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA RD985 UT WOS:A1995RD98500011 PM 7602128 ER PT J AU MCLANE, GF CASAS, L PEARTON, SJ ABERNATHY, CR AF MCLANE, GF CASAS, L PEARTON, SJ ABERNATHY, CR TI HIGH ETCH RATES OF GAN WITH MAGNETRON REACTIVE ION ETCHING IN BCL3 PLASMAS SO APPLIED PHYSICS LETTERS LA English DT Article ID MOLECULAR-BEAM EPITAXY; GAAS; INN C1 UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611. RP MCLANE, GF (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 10 TC 51 Z9 51 U1 0 U2 5 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 12 PY 1995 VL 66 IS 24 BP 3328 EP 3330 DI 10.1063/1.113746 PG 3 WC Physics, Applied SC Physics GA RC259 UT WOS:A1995RC25900031 ER PT J AU GRUBIC, Z STALC, A SENTJURC, M PECAR, S GENTRY, MK DOCTOR, BP AF GRUBIC, Z STALC, A SENTJURC, M PECAR, S GENTRY, MK DOCTOR, BP TI DIFFERENT EFFECTS OF 2 PERIPHERAL ANIONIC SITE-BINDING LIGANDS ON ACETYLCHOLINESTERASE ACTIVE-SITE GORGE TOPOGRAPHY REVEALED BY ELECTRON-PARAMAGNETIC-RESONANCE SO BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY LA English DT Article DE ACETYLCHOLINESTERASE; EPR; MONOCLONAL ANTIBODY; PROPIDIUM ID CONFORMATIONAL STABILITY; ORGANOPHOSPHATE; CHOLINESTERASE; ANTIBODY AB Both propidium and monoclonal antibody (mAb) 25B1 bind to the peripheral anionic site region of fetal bovine serum acetylcholinesterase (FBS AChE). Using electron paramagnetic resonance (EPR) with spin-labelled organophosphate specifically bound to the AChE active-site serine, we studied the effects of both ligands on the topography of the AChE active-site gorge. After incubation of FBS AChE with Fab fragments of mAb 25B1, freedom of motion of our spin label became more restricted, suggesting closing of the gorge. Stabilization against heat denaturation was also observed. No alterations in the freedom of motion or protection against heat denaturation could be detected after propidium binding. Our results demonstrate that two ligands binding to the peripheral anionic site region of AChE have different effects, suggesting a complex structure for this region of the molecule that allows various types of interactions with different ligands. We also demonstrate that EPR is a suitable tool for studying microtopographical alterations at the active sites of cholinesterases. C1 SCH MED,INST PATHOPHYSIOL,LJUBLJANA 61105,SLOVENIA. JOZEF STEFAN INST,LJUBLJANA 61000,SLOVENIA. FAC SCI & TECHNOL LJUBLJANA,DEPT PHARM,LJUBLJANA 61000,SLOVENIA. WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. NR 23 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-4838 J9 BBA-PROTEIN STRUCT M JI Biochim. Biophys. Acta-Protein Struct. Molec. Enzym. PD JUN 12 PY 1995 VL 1249 IS 2 BP 155 EP 160 DI 10.1016/0167-4838(95)00036-T PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA RD888 UT WOS:A1995RD88800005 PM 7599168 ER PT J AU RICE, BM GROSH, J THOMPSON, DL AF RICE, BM GROSH, J THOMPSON, DL TI VIBRATIONAL-MODE SELECTIVITY IN THE UNIMOLECULAR DECOMPOSITION OF CH2NNO2 SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID TRANSITION-STATE; SURFACE C1 OKLAHOMA STATE UNIV,DEPT CHEM,STILLWATER,OK 74078. RP RICE, BM (reprint author), USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 17 TC 12 Z9 12 U1 1 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD JUN 8 PY 1995 VL 102 IS 22 BP 8790 EP 8799 DI 10.1063/1.468932 PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA RC468 UT WOS:A1995RC46800011 ER PT J AU LEGGETT, DC AF LEGGETT, DC TI CRITICAL-EVALUATION OF PREDICTED AND MEASURED GAS-LIQUID PARTITION-COEFFICIENTS IN N-HEXADECANE - COMMENT SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Note RP LEGGETT, DC (reprint author), USA,COLD REG RES & ENGN LAB,GEOCHEM SCI BRANCH,HANOVER,NH 03755, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD JUN 8 PY 1995 VL 99 IS 23 BP 9638 EP 9638 DI 10.1021/j100023a049 PG 1 WC Chemistry, Physical SC Chemistry GA RC459 UT WOS:A1995RC45900049 ER PT J AU DESPER, CR BYRNE, CA LI, YJ CHU, B AF DESPER, CR BYRNE, CA LI, YJ CHU, B TI MORPHOLOGY STUDIES OF TRANS-1,4-DIISOCYANATOCYCLOHEXANE-BASED URETHANE ELASTOMERS BY SYNCHROTRON X-RAY-DIFFRACTION SO MACROMOLECULES LA English DT Article ID SMALL-ANGLE SCATTERING; STRUCTURE-PROPERTY RELATIONSHIPS; POLYURETHANE ELASTOMERS; BLOCK COPOLYMERS; SEGMENTED POLYURETHANE; MICRODOMAIN STRUCTURE; 2-PHASE SYSTEMS; LENGTH AB Urethane elastomers having hard segments based on CHDI [trans-1,4-diisocyanatocyclohexane] and BD [1,4-butanediol] are notable for their high softening temperatures and low hysteretic heat buildup. Experimental studies as a function of temperature using both wide- and small-angle X-ray diffraction of a series of such elastomers, incorporating PTMO [poly(tetramethylene oxide)] soft segments, reveal the persistence of hard-segment microdomains up to 275 degrees C. These hard-segment microdomains appear to be paracrystalline at ambient temperature, transforming to a glassy structure above ca. 100 degrees C. The glassy hard-segment structure is rigid to at least 275 degrees C, conferring rubbery properties on the material. Electron density variance data obtained by SAXS indicate that there is little hard- and soft-segment mixing at 30 degrees C for elastomers for which the molar ratio BD/PTMO is less than 2.0, with some segmental mixing indicated for higher BD/PTMO ratios. Changes in the microdomain structure with temperature are, for the most part, reversible for an elastomer with shorter hard segments corresponding to BD/PTMO = 1.5 but show marked irreversibility for one in which BD/PTMO = 3. These results are found to be consistent with models based on model compound data for the hard-segment packing. C1 SUNY STONY BROOK,DEPT CHEM,STONY BROOK,NY 11794. RP DESPER, CR (reprint author), USA,RES LAB,MAT DIRECTORATE,POLYMER RES BRANCH,WATERTOWN,MA 02172, USA. NR 42 TC 12 Z9 12 U1 2 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD JUN 5 PY 1995 VL 28 IS 12 BP 4213 EP 4226 DI 10.1021/ma00116a024 PG 14 WC Polymer Science SC Polymer Science GA RC247 UT WOS:A1995RC24700024 ER PT J AU AVERY, MA FAN, PC KARLE, JM MILLER, R GOINS, K AF AVERY, MA FAN, PC KARLE, JM MILLER, R GOINS, K TI REPLACEMENT OF THE NONPEROXIDIC TRIOXANE OXYGEN-ATOM OF ARTEMISININ BY CARBON - TOTAL SYNTHESIS OF (+)-13-CARBAARTEMISININ AND RELATED STRUCTURES SO TETRAHEDRON LETTERS LA English DT Article ID QINGHAOSU AB Provided by total synthesis, endoperoxides 17, 19 and 21 underwent intramolecular oxymercuration-demercuration leading respectively to formation of an isomeric tetracycle, (1aS,3S,5aS,6R,8aS,9R,12S)-10-deoxo-13-carbaartemisinin 18, (+)-10-deoxo-13-carbaartemisinin 20, and (+)-13-carbaartemisinin 4. Neither target 4 nor 20 displayed substantial antimalarial potency in vitro against Plasmodium falciparum, but the isomeric peroxide 18 possessed reasonable antimalarial potency in vitro. C1 UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677. UNIV N DAKOTA,DEPT CHEM,GRAND FORKS,ND 58202. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP AVERY, MA (reprint author), UNIV MISSISSIPPI,DEPT MED CHEM,UNIVERSITY,MS 38677, USA. NR 9 TC 22 Z9 25 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0040-4039 J9 TETRAHEDRON LETT JI Tetrahedron Lett. PD JUN 5 PY 1995 VL 36 IS 23 BP 3965 EP 3968 DI 10.1016/0040-4039(95)00689-A PG 4 WC Chemistry, Organic SC Chemistry GA RC810 UT WOS:A1995RC81000002 ER PT J AU MANAA, H GUYOT, Y DEGHOUL, F MONCORGE, R MERKLE, LD AF MANAA, H GUYOT, Y DEGHOUL, F MONCORGE, R MERKLE, LD TI EXCITED-STATE ABSORPTION IN MN5+SR-5(VO4)(3)F SO CHEMICAL PHYSICS LETTERS LA English DT Article ID ELECTRONIC-SPECTRUM; SR5(PO4)3CL; ION AB We report measurements of the excited state absorption (ESA) spectra of Mn:SVAP for both sigma and pi polarizations upon laser excitation at 700 nm. The results indicate that strong ESA with cross sections of the order of 10(-18) cm(2) covers most or all of the visible spectral region and extends to about 1150 nm. An even stronger ESA band exists in the blue and near ultraviolet region. The polarizations of the observed bands are not adequately explained by intraionic Mn5+ transitions, indicating that molecular orbital states lie at least as low as 24500 cm(-1). C1 USA,RES LAB,IR OPT TECHNOL OFC,FT BELVOIR,VA 22060. RP MANAA, H (reprint author), UNIV LYON 1,PHYSICOCHIM MAT LUMINESCENTS LAB,CNRS,URA 442,43 BLVD 11 NOVEMBRE 1918,F-69622 VILLEURBANNE,FRANCE. RI Manaa, Hacene/B-7320-2011; Guyot, Yannick/B-5847-2014 NR 8 TC 10 Z9 10 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD JUN 2 PY 1995 VL 238 IS 4-6 BP 333 EP 337 DI 10.1016/0009-2614(95)00404-R PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA RB391 UT WOS:A1995RB39100019 ER PT J AU PANGARO, L GIBSON, K RUSSELL, W LUCAS, C MARPLE, R AF PANGARO, L GIBSON, K RUSSELL, W LUCAS, C MARPLE, R TI A PROSPECTIVE, RANDOMIZED TRIAL OF A 6-WEEK AMBULATORY MEDICINE ROTATION SO ACADEMIC MEDICINE LA English DT Article ID INTERNAL-MEDICINE; CAREER CHOICE; EDUCATION AB Background. Medical schools are placing increased emphasis on training students in the ambulatory setting, but few studies show the benefit or academic risk of such innovation. The authors studied the effect of such a new rotation with a rigorous study design. Method. From a group of 166 third-year students at the Uniformed Services University of the Health Sciences F. Edward Hebert School of Medicine assigned in 1990-91 to do six weeks of their third-year medicine clerkship at Walter Reed Army Medical Center, 106 volunteers were randomized to six weeks either on the usual rotation on the general medicine wards (69 students) or to a new ambulatory rotation (37 students). Multiple pre-and postclerkship parameters were used to evaluate clerkship skills and knowledge; eventual internship choice was determined. Results. The randomization was successful. Postclerkship performance were the same in (1) the medicine subject examination of the National Board of Medical Examiners, (2) a multiple-choice test in interpreting laboratory results, (3) blinded rating by an expert panel of the quality of final written histories and physical exams, (4) blinded rating by an expert panel of the students' written case analyses of their own patients, and (5) a written multiple-step examination of problem-solving ability. Any differences between groups favored the ambulatory group. An increase in choice of primary care internships among students randomized to the ambulatory rotation was not significant. Conclusion. It is possible to study innovations rotations using a prospective, randomized design. Substituting a six-week block ambulatory experience for a ward rotation did not decrease students' abilities to write up or analyze complex cases. C1 UNIV N CAROLINA,MED CTR,DEPT RADIAT ONCOL,CHAPEL HILL,NC 27514. GEORGE WASHINGTON UNIV HOSP,WASHINGTON,DC 20037. BROOKE ARMY MED CTR,DEPT MED,GEN MED SERV,FT SAM HOUSTON,TX 78234. RP PANGARO, L (reprint author), UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT MED,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 12 TC 25 Z9 25 U1 0 U2 1 PU HANLEY & BELFUS INC PI PHILADELPHIA PA 210 S 13TH ST, PHILADELPHIA, PA 19107 SN 1040-2446 J9 ACAD MED JI Acad. Med. PD JUN PY 1995 VL 70 IS 6 BP 537 EP 541 DI 10.1097/00001888-199506000-00016 PG 5 WC Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA RE369 UT WOS:A1995RE36900023 PM 7786375 ER PT J AU SHIELS, WE AF SHIELS, WE TI RADIOLOGY OPPORTUNITIES IN THE MILITARY HEALTH-CARE SYSTEM SO ACADEMIC RADIOLOGY LA English DT Editorial Material RP SHIELS, WE (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSOC UNIV RADIOLOGISTS PI RESTON PA 1891 PRESTON WHITE DR, RESTON, VA 22091 SN 1076-6332 J9 ACAD RADIOL JI Acad. Radiol. PD JUN PY 1995 VL 2 IS 6 BP 544 EP 546 DI 10.1016/S1076-6332(05)80417-9 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA RA316 UT WOS:A1995RA31600014 PM 9419604 ER PT J AU KOHLMAN, WG PETRIE, SP AF KOHLMAN, WG PETRIE, SP TI MECHANICAL-PROPERTIES OF POLYCARBONATE-POLYSULFONE AND POLYCARBONATE-POLYETHERIMIDE BLENDS SO ADVANCES IN POLYMER TECHNOLOGY LA English DT Article AB Five, ten, and twenty percent by weight blends of polysulfone in polycarbonate and polyetherimide in polycarbonate were produced by melt blending. The materials were injection molded into plaques. Mechanical analysis consisting of tensile, pendulum impact, and ballistic impact testing was conducted using the plaques or samples machined from the plaques. The average impact strength and percentage of ductile failures decreased with increasing composition of polysulfone and polyetherimide. The tensile test results indicate that a relationship exists between the percent composition and the yield strength for the blends with the blends showing an improvement in tensile strength. The ballistic testing results show that a possibly linear relationship exists between the percent composition and the critical velocity for complete penetration. Differential scanning calorimetry was conducted to measure the glass transition temperatures of the materials. The presence of two glass transition temperatures and lack of transparency have indicated that the blends are immiscible. (C) 1995 John Wiley and Sons, Inc. C1 UNIV LOWELL,DEPT PLAST ENGN,LOWELL,MA 01854. RP KOHLMAN, WG (reprint author), USA,NATICK RES DEV & ENGN CTR,KANSAS ST,NATICK,MA 01760, USA. NR 21 TC 14 Z9 14 U1 0 U2 6 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-6679 J9 ADV POLYM TECH JI Adv. Polym. Technol. PD SUM PY 1995 VL 14 IS 2 BP 111 EP 127 DI 10.1002/adv.1995.060140203 PG 17 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA QV277 UT WOS:A1995QV27700003 ER PT J AU WASSERMAN, GM WRITER, JV AF WASSERMAN, GM WRITER, JV TI ASSOCIATION OF INCREASED AGE WITH INCIDENCE AND MORTALITY DUE TO INVASIVE STAPHYLOCOCCAL INFECTIONS IN THE UNITED-STATES-ARMY, 1980-1993 SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 1995 VL 141 IS 11 SU S BP S26 EP S26 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA RA788 UT WOS:A1995RA78800101 ER PT J AU WRITER, JV AF WRITER, JV TI HOSPITALIZATION FOR NON-BATTLE INJURIES AMONG US SOLDIERS IN SOUTHWEST ASIA, AUGUST 1990 JULY 1991 SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 1995 VL 141 IS 11 SU S BP S7 EP S7 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA RA788 UT WOS:A1995RA78800026 ER PT J AU BYRD, JC HARGIS, JB KESTER, KE HOSPENTHAL, DR KNUTSON, SW DIEHL, LF AF BYRD, JC HARGIS, JB KESTER, KE HOSPENTHAL, DR KNUTSON, SW DIEHL, LF TI OPPORTUNISTIC PULMONARY INFECTIONS WITH FLUDARABINE IN PREVIOUSLY TREATED PATIENTS WITH LOW-GRADE LYMPHOID MALIGNANCIES - A ROLE FOR PNEUMOCYSTIS-CARINII PNEUMONIA PROPHYLAXIS SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Article DE FLUDARABINE; OPPORTUNISTIC INFECTIONS; PNEUMOCYSTIS CARINII; CHRONIC LYMPHOCYTIC LEUKEMIA; LOW-GRADE LYMPHOMA ID CHRONIC LYMPHOCYTIC-LEUKEMIA; PHASE-II TRIAL; NERVOUS-SYSTEM TOXICITY; COMBINATION CHEMOTHERAPY; WALDENSTROMS MACROGLOBULINEMIA; PURINE ANTIMETABOLITE; MYCOSIS-FUNGOIDES; RANDOMIZED TRIAL; LONG-TERM; T-CELL AB The high incidence of opportunistic pulmonary infections in fludarabine-treated patients at Waiter Reed Army Medical Center (WRAMC) and in the literature are described. A CancerLlt search of fludarabine from June 1983-April 1994 with subsequent cross referencing and a retrospective review of all patients receiving fludarabine at WRAMC was performed, A total of 2,269 patients with low-grade lymphoid malignancies who received 7,547 + cycles of fludarabine were identified from the literature. Seventy-three (3.2%) of these patients developed opportunistic infections, Seventy-one (97%) of these infections occurred in patients who were pretreated with alkylator regimens or corticosteroids. Forty-five (2%) of these were of respiratory origin and associated with a 56% mortality rate, In contrast, 6 of the 21 patients (29%) treated with fludarabine at WRAMC developed opportunistic pulmonary infections which included three Pneumocystis carinii (PCP), one PCP/disseminated Candidiasis, one Mycobacterium avivm intracellulare, and one Aspergillus niger pneumonia. These infections developed during and after treatment with fludarabine in alkylator-resistant patients who had received corticosteroids before (n = 6), during (n = 1), or after (n = 4) fludarabine therapy. Lack of PCP prophylaxis was the only significant (P =.018) variable that differentiated patients who developed opportunistic pulmonary infections. Corticosteroid treatment before, during, or after fludarabine treatment in patients with alkylator-resistant, low-grade lymphoid malignancies who have not received PCP prophylaxis is associated with an increased risk of opportunistic pulmonary infections, Aggressive work-up of pulmonary syndromes and PCP prophylaxis in these patients should be considered during and after treatment with fludarabine. (C) 1995 Wiley-Liss, Inc.* C1 WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,GEN MED SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,PULM & CRIT CARE SERV,WASHINGTON,DC 20307. RP BYRD, JC (reprint author), WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. RI Kester, Kent/A-2114-2011 OI Kester, Kent/0000-0002-5056-0802 NR 92 TC 84 Z9 86 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD JUN PY 1995 VL 49 IS 2 BP 135 EP 142 DI 10.1002/ajh.2830490207 PG 8 WC Hematology SC Hematology GA RB015 UT WOS:A1995RB01500006 PM 7771465 ER PT J AU MIDKIFF, RB BOYKIN, MW MCFARLAND, DR BAUMAN, JA AF MIDKIFF, RB BOYKIN, MW MCFARLAND, DR BAUMAN, JA TI AGENESIS OF THE INTERNAL CAROTID-ARTERY WITH INTERCAVERNOUS ANASTOMOSIS SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article DE ARTERIES, ABNORMALITIES AND ANOMALIES; ARTERIES, CAROTID, INTERNAL; CAVERNOUS SINUS ID CONGENITAL ABSENCE; PARTIAL APLASIA; DIAGNOSIS AB We report a case of unilateral agenesis of the internal carotid artery with intercavernous anastomosis, a rare development anomaly. MR and carotid ultrasound, in association with clinical awareness, can be used to diagnose this condition. C1 BROOKE ARMY MED CTR,DEPT RADIOL,SAN ANTONIO,TX. RP MIDKIFF, RB (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307, USA. NR 22 TC 47 Z9 48 U1 0 U2 0 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD JUN-JUL PY 1995 VL 16 IS 6 BP 1356 EP 1359 PG 4 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA RC950 UT WOS:A1995RC95000033 PM 7677040 ER PT J AU MARINO, EA AF MARINO, EA TI SEX ESTIMATION USING THE FIRST CERVICAL VERTEBRA SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY LA English DT Article DE ARTICULAR REGION; SEX IDENTIFICATION; STATISTICAL TECHNIQUES; TERRY COLLECTION; HAMANN-TODD COLLECTION ID FRAGMENTARY CRANIA; BASE AB The articular surfaces and vertebral foramen area of the first cervical vertebra are sexually dimorphic and can be used to sex complete or fragmentary specimens. Eight measurements were taken from the articular regions (superior and inferior) of 100 first cervical vertebrae from Terry collection specimens housed at the Smithsonian Institution. Seven regression and seven discriminant function equations were created that predict sex with 77-85% and 75-85% accuracy, respectively. In separate control tests, measurements from 100 first cervical vertebrae from Hamann-Todd collection individuals (Cleveland Museum of Natural History) and from 34 archaeological specimens were used with the Terry equations. The control samples were sexed with 60-85% accuracy. (C) 1995 Wiley-Liss, Inc. RP MARINO, EA (reprint author), USA CORPS ENGINEERS,CURAT & ARCHIVES ANAL BRANCH,ST LOUIS DIST,1222 SPUCE ST,ST LOUIS,MO 63103, USA. NR 26 TC 31 Z9 33 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0002-9483 J9 AM J PHYS ANTHROPOL JI Am. J. Phys. Anthropol. PD JUN PY 1995 VL 97 IS 2 BP 127 EP 133 DI 10.1002/ajpa.1330970205 PG 7 WC Anthropology; Evolutionary Biology SC Anthropology; Evolutionary Biology GA RB108 UT WOS:A1995RB10800004 PM 7653504 ER PT J AU MCCARROLL, JE URSANO, RJ FULLERTON, CS AF MCCARROLL, JE URSANO, RJ FULLERTON, CS TI SYMPTOMS OF PTSD FOLLOWING RECOVERY OF WAR DEAD - 13-15-MONTH FOLLOW-UP SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Note ID POSTTRAUMATIC-STRESS-DISORDER; DISASTER; VICTIMS AB Objective: The authors explored whether individuals who participated In the recovery of war dead were more likely to experience later symptoms of posttraumatic stress disorder (PTSD) than were individuals who were not involved in the recovery of war dead. Method: PTSD symptoms were assessed by questionnaire in men and women who had or had not handled human remains during the Persian Gulf War: 116 melt and women who had and 118 who had not handled human remains participated in the study 3-5 months after returning from the war; 55 of the subjects who had and 56 of those who had not handled human remains participated in a follow-up assessment 13-15 months after their return. Results: Subjects who had been involved in the recovery of war dead had significantly higher symptom levels than comparison subjects at both time points. Conclusions: After more than 1 year, individuals who had handled human remains during wartime were at higher risk for PTSD symptoms than those who had not. C1 UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT PSYCHIAT,BETHESDA,MD 20814. RP MCCARROLL, JE (reprint author), WALTER REED ARMY MED CTR,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 17 TC 39 Z9 39 U1 0 U2 1 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD JUN PY 1995 VL 152 IS 6 BP 939 EP 941 PG 3 WC Psychiatry SC Psychiatry GA RC494 UT WOS:A1995RC49400024 PM 7755130 ER PT J AU DEAVERS, M GUINEE, D KOSS, MN TRAVIS, WD AF DEAVERS, M GUINEE, D KOSS, MN TRAVIS, WD TI GRANULAR-CELL TUMORS OF THE LUNG - CLINICOPATHOLOGICAL STUDY OF 20 CASES SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Article DE GRANULAR CELL TUMOR; MYOBLASTOMA; GRANULAR CELL MYOBLASTOMA; LUNG CARCINOMA ID MYOBLASTOMA; BRONCHUS; BENIGN; CARCINOMA; CYTOLOGY; LASER AB Granular cell tumor (GCT) of the lung is a rare neoplasm comprising 6-10% of all GCT. Since it was first described in the bronchus by Kramer in 1939, less than 80 cases have been reported. We present the clinicopathologic features of 23 GCT from 20 patients. The patients ranged in age from 20 to 57 years (median, 45 years) and included 10 males and 10 females. Of the 19 patients with available histories, nine (47%) were incidental findings and 10 (53%) had obstructive symptoms [pneumonia, 7 (37%); atelectasis, 3 (16%)]. Three (16%) had hemoptysis, and one (5%) had weight loss. The GCT were solitary in 15 patients (75%) and multiple in five others (25%). One patient had three endobronchial lesions, and another had one endobronchial and one peripheral pulmonary lesion. Three of the patients had multiple cutaneous GCT (15%). Grossly, they were polypoid or nodular, tan-yellow, and firm. Histologically, the endobronchial GCT consisted of submucosal infiltrates of round to oval cells with abundant granular cytoplasm. The tumor often infiltrated into peribronchial tissue and in one case focally infiltrated an adjacent lymph node. Hyalinized thickening of the subepithelial basement membrane was common; the overlying epithelium often showed squamous metaplasia or ulceration. In those patients with available follow-up, the clinical behavior of lung GCT was benign. Our experience supports a conservative approach to therapy in most cases unless there has been extensive postobstructive lung injury. Potential conservative therapeutic approaches include bronchoscopic extirpation, laser therapy, or sleeve resection. The histogenesis of GCT is not known, although most studies suggest a peripheral nerve sheath origin. Our immunohistochemical results with positive staining for antibodies to S100 (4/4), NSE (3/3), vimentin (4/4), and actin (4/4, focal) are consistent with this concept. C1 ARMED FORCES INST PATHOL,DEPT PULM & MEDIASTINAL PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. NR 48 TC 30 Z9 32 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD JUN PY 1995 VL 19 IS 6 BP 627 EP 635 DI 10.1097/00000478-199506000-00002 PG 9 WC Pathology; Surgery SC Pathology; Surgery GA QY755 UT WOS:A1995QY75500002 PM 7755149 ER PT J AU PERICH, MJ HOCH, AL RIZZO, N ROWTON, ED AF PERICH, MJ HOCH, AL RIZZO, N ROWTON, ED TI INSECTICIDE BARRIER SPRAYING FOR THE CONTROL OF SAND FLY VECTORS OF CUTANEOUS LEISHMANIASIS IN RURAL GUATEMALA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID FLIES DIPTERA; PSYCHODIDAE; BRAZILIENSIS; DISPERSAL AB An initial evaluation of insecticide barrier spraying directed against sand fly vectors of cutaneous leishmaniasis was done in a nonclimax forested area with heavy undergrowth in Peten, Guatemala. A 100 m-wide swath of vegetation was sprayed once with a 1:3 mixture of cyfluthrin insecticide and a palm oil carrier using back-pack sprayers to simulate a central cantonment area in one site while another site remained as an untreated control. Prior to spraying and throughout 87 days post-treatment, sand fly populations were monitored at both sites with light traps set at ground and canopy levels at 50-m intervals radiating out from the centers of the cantonments, 150-m in the four cardinal directions. A total of 2,876 female sand flies were captured, representing 16 species. Three species, Brumptomyia galindoi, Lutzomyia panamensis, and Lu. ovallesi, comprised 70% of the total collection. The single insecticide barrier significantly reduced sand flies from reaching the cantonment area for more than 80 days, while sand fly populations outside the treated cantonment and in the untreated (control) cantonment remained high (52 sand flies in the treated cantonment versus 235 sand flies in the untreated cantonment). C1 UNIV VALLE GUATEMALA,DEPT BIOL,GUATEMALA CITY,GUATEMALA. RP PERICH, MJ (reprint author), WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 NR 17 TC 19 Z9 20 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1995 VL 52 IS 6 BP 485 EP 488 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA RK696 UT WOS:A1995RK69600002 PM 7611551 ER PT J AU CLAYSON, ET INNIS, BL MYINT, KSA SNITBHAN, R VAUGHN, DW SHRESTHA, MP AF CLAYSON, ET INNIS, BL MYINT, KSA SNITBHAN, R VAUGHN, DW SHRESTHA, MP TI RELATIVE RISK OF HEPATITIS-A AND HEPATITIS-E AMONG FOREIGNERS IN NEPAL - SHORT REPORT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID NON-B HEPATITIS; NON-A AB Sera from two groups of patients in Nepal with acute hepatitis were examined for the presence of antibodies to the hepatitis A, B, C, and E viruses to determine the etiology of viral hepatitis. The first group consisted of 43 consecutive acute hepatitis patients presenting at a clinic for tourists and foreign residents in Kathmandu from January 1987 to June 1988. The other group consisted of 95 consecutive acute hepatitis patients admitted during the same period at a hospital used predominantly by adult Nepalese residents of Kathmandu. Hepatitis A was diagnosed in 39 (91%) of the foreign patients and in one of the 95 Nepalese patients, whereas hepatitis E was diagnosed in four of the 43 foreign patients and in 90 (95%) of the Nepalese patients. No cases of hepatitis B or C were identified in either group, nor were any cases of dual infection with the hepatitis A virus (HAV) and hepatitis E virus (HEV) identified. These results suggest that in the Kathmandu Valley, hepatitis A is the predominant form of hepatitis among foreigners, hepatitis E is the predominant form of hepatitis among adult Nepalese, and both HAV and HEV are endemic to the Kathmandu Valley. C1 USA MED COMPONENT,ARMED FORCES RES INST MED SCI,DEPT VIROL,BANGKOK,THAILAND. NR 10 TC 22 Z9 22 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1995 VL 52 IS 6 BP 506 EP 507 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA RK696 UT WOS:A1995RK69600006 PM 7611554 ER PT J AU SMITH, PBW SNYDER, AP HARDEN, CS AF SMITH, PBW SNYDER, AP HARDEN, CS TI CHARACTERIZATION OF BACTERIAL PHOSPHOLIPIDS BY ELECTROSPRAY-IONIZATION TANDEM MASS-SPECTROMETRY SO ANALYTICAL CHEMISTRY LA English DT Article ID FAST-ATOM-BOMBARDMENT; FATTY-ACIDS; CHARGE-STATE; ION-SOURCE; MS/MS AB A negative ion electrospray ionization tandem mass spectrometric technique was developed for the analysis of glycerophospholipids. Examination of the product ion mass spectrum of the deprotonated molecular ion provided sufficient information to identify both the class of glycerophospholipid and the molecular weights of the two fatty acid moieties. This technique was applied to the profiling of glycerophospholipids present in the chloroform/methanol extracts of four different bacterial species. The principal bacterial phospholipids detected by this technique were phosphatidylglycerols and diphosphatidylglycerols, accompanied by small amounts of phosphatidylethanolamines for two of the bacterial species examined. The fatty acid composition of the phosphatidylglycerols for each bacteria was determined by tandem mass spectrometry and presented graphically. Differences in the fatty acid composition for each bacterial species were readily apparent from a visual examination of the data sets. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. RP SMITH, PBW (reprint author), GEOCENTERS INC,GUNPOWDER BRANCH,POB 68,ABERDEEN PROVING GROUND,MD 21010, USA. NR 38 TC 116 Z9 120 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD JUN 1 PY 1995 VL 67 IS 11 BP 1824 EP 1830 DI 10.1021/ac00107a011 PG 7 WC Chemistry, Analytical SC Chemistry GA RA091 UT WOS:A1995RA09100015 PM 9306733 ER PT J AU SMITH, L MCFADDEN, ER AF SMITH, L MCFADDEN, ER TI BRONCHIAL HYPERREACTIVITY REVISITED SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Review ID EXERCISE-INDUCED ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; STEROID-DEPENDENT ASTHMA; LONG-TERM TREATMENT; PLATELET-ACTIVATING FACTOR; ALLERGEN-INDUCED INCREASE; AIR-FLOW OBSTRUCTION; EUCAPNIC VOLUNTARY HYPERVENTILATION; PEAK EXPIRATORY FLOW; MAST-CELL ACTIVATION AB Objective: The purpose of this article is to review bronchial reactivity: how it is detected, what are the clinical and pathologic correlates and what treatment modulates it. Is it a good diagnostic test for a disease such as asthma? Is it a reasonable parameter to follow in assessing disease severity and response to treatment? Data Sources: Recent studies on human subjects in the English language medical Literature involving bronchial hyperreactivity. In particular all studies were sought that correlated indices of inflammation obtained either by bronchoalveolar lavage or biopsy with degree of bronchial hyperresponsiveness. Pertinent studies reviewing disease association with presence of bronchial hyperreactivity were sought. All studies of treatment with inhaled corticosteroids were reviewed and those in which the subjects could be classified as having either mild or moderately severe asthma on the basis of the clinical information given were used to provide data on correlation of bronchial reactivity and disease severity. Results: The relationship of bronchial reactivity and any disease state is not straightforward. It is not clear what causes hyperreactivity of the airways but there must be other factors besides inflammation as bronchial hyperreactivity can occur without microscopic evidence of inflammation. Hyperresponsiveness does not appear to be as sensitive or specific for the diagnosis of asthma as previously thought, or as closely related to the severity of asthma. Effects of treatment appear to be somewhat independent of their impact on bronchial responsiveness. Conclusions: Airway hyperresponsiveness can be found in many circumstances. Its relationship to symptom production and clinical course in any disease is not clear. Further studies are needed to elucidate the relationship between airways hyperreactivity, asthma, and other lung diseases and the factors that lead to increased bronchial reactivity. C1 CASE WESTERN RESERVE UNIV,SCH MED,DEPT MED,DIV PULM & CRIT CARE MED,CLEVELAND,OH 44106. RP SMITH, L (reprint author), WALTER REED ARMY MED CTR,ALLERGY CLIN IMMUNOL SERV,WASHINGTON,DC 20307, USA. FU NHLBI NIH HHS [HL-37117, HL-33791, HL-44495] NR 218 TC 50 Z9 50 U1 0 U2 1 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD JUN PY 1995 VL 74 IS 6 BP 454 EP 470 PG 17 WC Allergy; Immunology SC Allergy; Immunology GA RE236 UT WOS:A1995RE23600002 PM 7788511 ER PT J AU ROBERTS, WL BERMAN, JD RAINEY, PM AF ROBERTS, WL BERMAN, JD RAINEY, PM TI IN-VITRO ANTILEISHMANIAL PROPERTIES OF TRIVALENT AND PENTAVALENT ANTIMONIAL PREPARATIONS SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID VISCERAL LEISHMANIASIS; SODIUM STIBOGLUCONATE; CHEMOTHERAPY; MACROPHAGES; AMASTIGOTES; TRYPANOSOMES; PENTAMIDINE; MEXICANA AB To better understand the antileishmanial effects of antimonial agents we synthesized complexes of tri- and pentavalent antimony with mannan. The 50% inhibitory concentrations (IC(50)s) of these agents, along with those of potassium antimony tartrate [SB(III)] and sodium stibogluconate [Sb(V)], were determined for promastigotes and intramacrophage amastigotes. The trivalent antimonial agents were more potent than the pentavalent agents, Although the IC(50)s were 60- to more-than-600-fold higher for promastigotes than for amastigotes, similar intracellular antimony concentrations in both life forms were measured after incubation with all four drugs at their respective IC(50)s. Macrophages accumulated antimony during a 4-h exposure that was retained intracellularly for at least 3 days. Amastigotes inside macrophages had a higher antimony content 6 days after a single 4-h treatment than they did immediately after treatment, suggesting that macrophages serve as a reservoir for antimonial agents and prolong parasite exposure, Macrophages concentrated antimony from the medium with potassium antimony tartrate, trivalent antimony-mannan, and pentavalent antimony-mannan treatments. N-Acetylcysteine antagonized the antileishmanial effects of these three drugs against intracellular amastigotes; in contrast, it had minimal effects on the action of sodium stibogluconate. C1 YALE UNIV,SCH MED,DEPT LAB MED,NEW HAVEN,CT 06520. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 25 TC 93 Z9 99 U1 2 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUN PY 1995 VL 39 IS 6 BP 1234 EP 1239 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA RB370 UT WOS:A1995RB37000002 PM 7574507 ER PT J AU MEISELMAN, HL MASTROIANNI, GR MACDONALD, H BULLER, ME EDWARDS, JSA AF MEISELMAN, HL MASTROIANNI, GR MACDONALD, H BULLER, ME EDWARDS, JSA TI STABILITY OF FOOD ATTITUDES IN STUDENTS ENTERING UNIVERSITY SO APPETITE LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. BOURNEMOUTH UNIV,POOLE,DORSET,ENGLAND. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ACADEMIC PRESS (LONDON) LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0195-6663 J9 APPETITE JI Appetite PD JUN PY 1995 VL 24 IS 3 BP 283 EP 283 PG 1 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA RC946 UT WOS:A1995RC94600064 ER PT J AU SCHUTZ, HG CARDELLO, AV AF SCHUTZ, HG CARDELLO, AV TI EXPECTATIONS, APPROPRIATENESS AND PREFERENCE AS PREDICTORS OF FOOD CHOICE SO APPETITE LA English DT Meeting Abstract C1 UNIV CALIF DAVIS,DEPT FOOD SCI,DAVIS,CA 95616. USA,NATICK RES DEV & ENGN CTR,SCI & TECHNOL DIRECTORATE,CONSUMER RES BRANCH,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ACADEMIC PRESS (LONDON) LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0195-6663 J9 APPETITE JI Appetite PD JUN PY 1995 VL 24 IS 3 BP 298 EP 298 PG 1 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA RC946 UT WOS:A1995RC94600106 ER PT J AU YU, FTS ZHANG, JZ YIN, SZ RUFFIN, PB AF YU, FTS ZHANG, JZ YIN, SZ RUFFIN, PB TI ANALYSIS OF A FIBER SPECKLEGRAM SENSOR BY USING COUPLED-MODE THEORY SO APPLIED OPTICS LA English DT Article AB The performance of the fiber specklegram sensor (FSS) by use of the waveguide coupled-mode theory is analyzed. The analyses are based on the microbending effect on the sensing fiber, in which we have found that the sensitivity of the FSS is affected by the core diameter and the bending geometry. Experimental confirmations of the analyses are also provided in which we have shown that experimental data are consistent with the analyses. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP YU, FTS (reprint author), PENN STATE UNIV,DEPT ELECT & COMP ENGN,UNIVERSITY PK,PA 16802, USA. NR 10 TC 10 Z9 10 U1 1 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUN 1 PY 1995 VL 34 IS 16 BP 3018 EP 3023 PG 6 WC Optics SC Optics GA RB344 UT WOS:A1995RB34400028 PM 21052457 ER PT J AU GUITART, J MICALI, G NORTON, SA AF GUITART, J MICALI, G NORTON, SA TI A YOUNG-ADULT WITH A RECALCITRANT SCALP FOLLICULITIS - LANGERHANS CELL HISTIOCYSTOSIS (LCDH) PRESENTING AS SCALP FOLLICULITIS IN AN ADULT SO ARCHIVES OF DERMATOLOGY LA English DT Note ID HISTIOCYTOSIS-X C1 TRIPLER ARMY MED CTR,HONOLULU,HI. RP GUITART, J (reprint author), UNIV ILLINOIS,CHICAGO,IL 60612, USA. NR 7 TC 6 Z9 6 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JUN PY 1995 VL 131 IS 6 BP 719 EP 724 PG 6 WC Dermatology SC Dermatology GA RC497 UT WOS:A1995RC49700015 PM 7778926 ER PT J AU CALDWELL, L VOGELGESANG, SA MEWSHAW, EA DENNIS, GJ AF CALDWELL, L VOGELGESANG, SA MEWSHAW, EA DENNIS, GJ TI PRIMARY, PRINCIPAL AND SUBSPECIALTY CARE IN AN ACADEMIC RHEUMATOLOGY CLINIC SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,RHEUMATOL SERV,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD JUN PY 1995 VL 38 IS 6 SU S BP R26 EP R26 PG 1 WC Rheumatology SC Rheumatology GA RD908 UT WOS:A1995RD90800089 ER PT J AU DOYLE, JJ FINGER, DR DENNIS, GJ ELIASSON, AH AF DOYLE, JJ FINGER, DR DENNIS, GJ ELIASSON, AH TI AIRWAY HYPERREACTIVITY IN RHEUMATOID-ARTHRITIS SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD JUN PY 1995 VL 38 IS 6 SU S BP R22 EP R22 PG 1 WC Rheumatology SC Rheumatology GA RD908 UT WOS:A1995RD90800068 ER PT J AU GRADY, EP CARPENTER, MT BATTAFARANO, DF OLDER, SA AF GRADY, EP CARPENTER, MT BATTAFARANO, DF OLDER, SA TI RHEUMATOLOGIC FINDINGS IN PERSIAN-GULF-WAR VETERANS SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WILFORD HALL USAF MED CTR,SAN ANTONIO,TX. BROOKE ARMY MED CTR,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD JUN PY 1995 VL 38 IS 6 SU S BP R17 EP R17 PG 1 WC Rheumatology SC Rheumatology GA RD908 UT WOS:A1995RD90800056 ER PT J AU MURPHY, FT DENNIS, GJ AF MURPHY, FT DENNIS, GJ TI THE CLINICAL-SIGNIFICANCE OF REACTIVE FLUORESCENT TREPONEMAL ANTIBODY SEROLOGIES IN PATIENTS WITH SLE SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT RHEUMATOL,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD JUN PY 1995 VL 38 IS 6 SU S BP R24 EP R24 PG 1 WC Rheumatology SC Rheumatology GA RD908 UT WOS:A1995RD90800078 ER PT J AU POJMAN, L AF POJMAN, L TI THEORIES OF EQUALITY - A CRITICAL ANALYSIS SO BEHAVIOR AND PHILOSOPHY LA English DT Article RP POJMAN, L (reprint author), US MIL ACAD,DEPT ENGLISH & PHILOS HUMANIT,W POINT,NY 10996, USA. NR 43 TC 0 Z9 1 U1 0 U2 0 PU CAMBRIDGE CTR BEHAV STUDIES PI CAMBRIDGE PA 675 MASSACHUSETTS AVE, CAMBRIDGE, MA 02139-3309 SN 0090-4155 J9 BEHAV PHILOS JI Behav. Philos. PD SUM PY 1995 VL 23 IS 2 BP 1 EP 27 PG 27 WC Ethics; Psychology, Multidisciplinary SC Social Sciences - Other Topics; Psychology GA TH382 UT WOS:A1995TH38200001 ER PT J AU GATTOMENKING, DL YU, H BRUNO, JG GOODE, MT MILLER, M ZULICH, AW AF GATTOMENKING, DL YU, H BRUNO, JG GOODE, MT MILLER, M ZULICH, AW TI SENSITIVE DETECTION OF BIOTOXOIDS AND BACTERIAL-SPORES USING AN IMMUNOMAGNETIC ELECTROCHEMILUMINESCENCE SENSOR SO BIOSENSORS & BIOELECTRONICS LA English DT Article DE BACTERIAL SPORES; BIOTOXINS; ELECTROCHEMILUMINESCENCE; IMMUNOMAGNETICS; MAGNETIC BEADS ID MAGNETIC SEPARATION; ESCHERICHIA-COLI; CELL-SEPARATION; BEADS; ANTIGEN; IMMUNOASSAYS; PARTICLES; KINETICS; INVITRO; ASSAYS AB Extremely sensitive detection of various biotoxoids and bacterial spores using the commercial ORIGEN(R) analyzer was achieved by capture on antibody-conjugated micron sized magnetic beads (MBs) followed by binding of ruthenium (II) trisbipyridal chelate (Ru(bpy)(3)(2+))-labelled reporter antibodies. Immunomagnetically captured target materials were collected on a magnet. Electrochemiluminescence (ECL) was evoked from the Ru(bpy)(3)(2+)-tagged reporter antibodies by application of an electrical potential. Femtogram sensitivity levels were obtained for all biotoxoids tested including botulinus A, cholera beta subunit. ricin and staphylococcal enterotoxoid B by this immunomagnetic (IM)-ECL approach. An IM-ECL assay for Bacillus anthracis spores yielded a detection limit of at least 100 spores. The ECL signal was a function of analyte quantity over several orders of magnitude, but the immunological 'hook' effect at high antigen loads made quantitation impossible over a broader range. All assays were performed with a maximum combined incubation and assay time of approximately 40 min. This work demonstrates the extreme sensitivity of the IM-ECL approach for soluble and particulate antigens. C1 SCI & TECHNOL CORP, EDGEWOOD, MD 21040 USA. OPERAT TECHNOL CORP, SAN ANTONIO, TX 78229 USA. USA, USAF,EDGEWOOD RES DEV & ENGN CTR, CREW SYST DIRECTORATE,ARMSTRONG LAB, ABERDEEN PROVING GROUND, MD 21010 USA. NR 32 TC 108 Z9 115 U1 1 U2 12 PU ELSEVIER ADVANCED TECHNOLOGY PI OXFORD PA OXFORD FULFILLMENT CENTRE THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0956-5663 EI 1873-4235 J9 BIOSENS BIOELECTRON JI Biosens. Bioelectron. PD SUM PY 1995 VL 10 IS 6-7 BP 501 EP 507 DI 10.1016/0956-5663(95)96925-O PG 7 WC Biophysics; Biotechnology & Applied Microbiology; Chemistry, Analytical; Electrochemistry; Nanoscience & Nanotechnology SC Biophysics; Biotechnology & Applied Microbiology; Chemistry; Electrochemistry; Science & Technology - Other Topics GA RH052 UT WOS:A1995RH05200001 PM 7612203 ER PT J AU POILLON, WN KIM, BC LABOTKA, RJ HICKS, CU KARK, JA AF POILLON, WN KIM, BC LABOTKA, RJ HICKS, CU KARK, JA TI ANTISICKLING EFFECTS OF 2,3-DIPHOSPHOGLYCERATE DEPLETION SO BLOOD LA English DT Article ID SICKLE-CELL-ANEMIA; NUCLEAR MAGNETIC-RESONANCE; HUMAN ERYTHROCYTES; INTRACELLULAR PH; HEMOGLOBIN; DETERMINANTS; PHOSPHATASE AB Elevation of 2,3-bisphosphoglycerate (2,3-DPG) in sickle erythrocytes (SS RBCs) and concomitant acidification of the cell interior promote polymerization by decreasing the solubility (c(sat)) of deoxyhemoglobin S. The antisickling effect of 2,3-DPG depletion was evaluated after activation of the 2,3-DPG phosphatase activity of bisphosphoglycerate mutase by glycolate-2-phosphate, leading to rapid loss of intracellular 2,3-DPG. To ensure its maximal reduction in a physiologic medium, isosmotic CO2/bicarbonate-buffered saline, pH 7.0, was used. Substitution of K+ for Na+ as the major extracellular cation suppressed K:Cl cotransport, prevented cell shrinkage, and allowed demonstration of the full antisickling effect of 2,3-DPG depletion. The modest effect on solubility per seof removing intraerythrocytic 2,3-DPG (Delta c(sat) = 1.6 g/dL) was amplified into a much larger antisickling effect by interaction with three other cellular variables affecting solubility and polymer content (intracellular pH, O-2 saturation, and mean cell hemoglobin concentration). Acting in concert, these four antisickling effects (three solubilizing, one osmotic) reduced polymer fraction of glycolate-treated SS RBCs by 32% to 63%, with a concomitant decrease in sickling of 46% to 95% at the nominal pO(2) of the microcirculation (20 mm Hg). A decrement in sickling of this magnitude should significantly ameliorate the vasoocclusive severity of sickle cell disease. (C) 1995 by The American Society of Hematology. C1 HOWARD UNIV,COLL MED,CTR SICKLE CELL DIS,WASHINGTON,DC 20059. HOWARD UNIV,COLL MED,DEPT PEDIAT & CHILD HLTH,WASHINGTON,DC 20059. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT HEMATOL,DIV MED,WASHINGTON,DC 20307. RP POILLON, WN (reprint author), UNIV ILLINOIS,CHICAGO COLL MED,DEPT PEDAIT MC856,DIV HEMATOL ONCOL,840 S WOOD ST,CHICAGO,IL 60612, USA. NR 47 TC 17 Z9 17 U1 3 U2 9 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD JUN 1 PY 1995 VL 85 IS 11 BP 3289 EP 3296 PG 8 WC Hematology SC Hematology GA RA136 UT WOS:A1995RA13600037 PM 7756662 ER PT J AU ADAMS, WF BRADY, SG AF ADAMS, WF BRADY, SG TI REDISCOVERY OF THE AQUATIC GASTROPOD HELISOMA-EUCOSMIUM (BARTSCH, 1908), (BASOMMATOPHORA, PLANORBIDAE) SO BRIMLEYANA LA English DT Article AB A population of Helisoma eucosmium (Bartsch, 1908), a small freshwater planorbid snail considered to be extinct by some authors, has been discovered in Town Creek, a tidal swamp stream in southeastern North Carolina. This rediscovery will permit a definitive determination of the proper systematic placement of the taxon. In the absence of live specimens, past analysis of this taxon during systematic revisions of the Planorbidae relied only on shell morphology of type material. Under this circumstance, this taxon was variously placed in both tropical and temperate genera and, compounding that problem, was treated as a full species by some authors and a subspecies by others. Its apparently limited range elevates concern for the conservation of planorbid snail diversity in southeastern North Carolina because it is the second taxon with a severely restricted distribution to be found in this rapidly urbanizing region. RP ADAMS, WF (reprint author), USA, CORPS ENGINEERS, ENVIRONM RESOURCES BRANCH, POB 1890, WILMINGTON, NC 28402 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NORTH CAROLINA STATE MUSEUM NATURAL SCIENCES PI RALEIGH PA C/O DIRECTOR OF RESEARCH, PO BOX 29555, RALEIGH, NC 27626-0555 USA SN 0193-4406 J9 BRIMLEYANA JI Brimleyana PD JUN PY 1995 IS 22 BP 23 EP 29 PG 7 WC Zoology SC Zoology GA TA981 UT WOS:A1995TA98100004 ER PT J AU MORRISON, EE EBELING, RM AF MORRISON, EE EBELING, RM TI LIMIT EQUILIBRIUM COMPUTATION OF DYNAMIC PASSIVE EARTH PRESSURE SO CANADIAN GEOTECHNICAL JOURNAL LA English DT Article DE PSEUDOSTATIC; DYNAMIC; PASSIVE EARTH PRESSURE AB Few solution techniques exist for the determination of pseudostatic dynamic passive earth pressures for cohesionless soils. The widely accepted Mononobe-Okabe equation can result in the computing of unconservative values if the wall interface friction angle is greater than half the soil internal friction angle. As an alternate solution, equilibrium equations were formulated assuming a log spiral failure surface, and a research computer program was written to calculate the dynamic passive earth pressure coefficient. The primary purpose of this paper is to present a comparison of results obtained using the Mononobe-Okabe equation with those obtained using the log spiral formulation. RP MORRISON, EE (reprint author), USA,ENGINEER WATERWAYS EXPT STN,CEWES IM DS,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 9 TC 21 Z9 27 U1 1 U2 5 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-3674 J9 CAN GEOTECH J JI Can. Geotech. J. PD JUN PY 1995 VL 32 IS 3 BP 481 EP 487 PG 7 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA RL917 UT WOS:A1995RL91700008 ER PT J AU SHOOP, SA AF SHOOP, SA TI VEHICLE BEARING CAPACITY OF FROZEN GROUND OVER A SOFT SUBSTRATE SO CANADIAN GEOTECHNICAL JOURNAL LA English DT Note DE BEARING CAPACITY; FROZEN GROUND; PEAT; FROST; VEHICLE MOBILITY; STRENGTH AB Freezing temperatures may allow the use of vehicles and heavy equipment on otherwise inaccessible or sensitive areas such as swamps, bogs, tundra, and peatlands. Predicting operable conditions on frozen ground is useful for forestry, mining, oil exploration, construction, and military operations. Guidelines for estimating the frost depth necessary to support a given vehicle load have been generated based on experience in forestry operations on peatlands and similarities in the strength behavior of frozen peat and frozen soils. Correlation with information in the literature leads to a simple equation relating safe trafficability of frozen ground over soft ground: P = Cz(2), where P is the maximum load and C is a constant depending on the strength of the frozen layer, which has a thickness z. Values for the constant C and a chart showing required frozen thickness for a variety of vehicles are given. RP SHOOP, SA (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 15 TC 10 Z9 10 U1 1 U2 5 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-3674 J9 CAN GEOTECH J JI Can. Geotech. J. PD JUN PY 1995 VL 32 IS 3 BP 552 EP 556 PG 5 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA RL917 UT WOS:A1995RL91700015 ER PT J AU KUZMA, PJ MCLOUGHLIN, TM ENGLER, RJM AF KUZMA, PJ MCLOUGHLIN, TM ENGLER, RJM TI CARDIAC-ARREST AFTER INTRAUTERINE INSTILLATION OF 32-PERCENT DEXTRAN-70 DURING HYSTEROSCOPY SO CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE LA English DT Letter ID ANAPHYLACTOID REACTIONS RP KUZMA, PJ (reprint author), WALTER REED ARMY MED CTR,ANESTHESIA & OPERAT SERV,6900 GEORGIA AVE,WASHINGTON,DC 20307, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU CANADIAN ANAESTHETISTS SOC INC PI TORONTO PA 1 EGLINTON AVE EAST, SUITE 208, TORONTO ON M4P 3A1, CANADA SN 0832-610X J9 CAN J ANAESTH JI Can. J. Anaesth.-J. Can. Anesth. PD JUN PY 1995 VL 42 IS 6 BP 557 EP 557 PG 1 WC Anesthesiology SC Anesthesiology GA RA058 UT WOS:A1995RA05800025 PM 7543027 ER PT J AU Blaney, SM Cole, DE Godwin, K Sung, C Poplack, DG Balis, FM AF Blaney, SM Cole, DE Godwin, K Sung, C Poplack, DG Balis, FM TI Intrathecal administration of topotecan in nonhuman primates SO CANCER CHEMOTHERAPY AND PHARMACOLOGY LA English DT Article DE topotecan; meningeal malignancies; intrathecal ID CEREBROSPINAL-FLUID; PHASE-I AB The cerebrospinal fluid (CSF) pharmacokinetics of topotecan were studied in a nonhuman primate model following intraventricular administration of 0.1 mg. Lactone and total drug concentrations were measured using a reverse-phase HPLC method with fluorescence detection. The mean peak concentrations of lactone and total drug in ventricular CSF were 83 +/- 18 mu M and 88 +/- 25 mu M, respectively. CSF drug elimination of the lactone was bi-exponential with a terminal half-life of 1.3 h. The mean clearance from ventricular CSF was 0.075 ml/min for the lactone and 0.043 ml/min for total drug. The ventricular CSF drug exposure (AUC) to lactone was 450-fold greater following intraventricular administration of 0.1 mg topotecan than after systemic intravenous administration of a 40-fold higher dose (10 mg/m(2)). Peak lumbar concentrations (n = 1), which occurred 2 h after intraventricular drug administration, were 0.98 mu M and 2.95 mu M for the lactone and total drug, respectively. A transient CSF pleocytosis was observed in one animal following intraventricular topotecan administration and in one animal following intralumbar topotecan administration. No other acute or chronic neurologic or systemic toxicities were observed following a single intraventricular dose or weekly (x4) intralumbar topotecan. Compared with systemic topotecan, intrathecal administration provided a significant pharmacokinetic advantage in terms of CSF drug exposure and did not produce any significant neurotoxicity in a nonhuman primate model. Intrathecal topotecan should be evaluated clinically as a potential alternative therapy for refractory meningeal tumors. C1 NCI,PEDIAT BRANCH,BETHESDA,MD 20892. NIH,NATL CTR RES RESOURCES,BIOMED ENGN & INSTRUMENTAT PROGRAM,BETHESDA,MD 20892. TEXAS CHILDRENS HOSP,HOUSTON,TX 77030. RP Blaney, SM (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 15 TC 35 Z9 35 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0344-5704 J9 CANCER CHEMOTH PHARM JI Cancer Chemother. Pharmacol. PD JUN PY 1995 VL 36 IS 2 BP 121 EP 124 PG 4 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA QY585 UT WOS:A1995QY58500005 PM 7767947 ER PT J AU ASHCOM, TL JOHNS, JP BAILEY, SR RUBAL, BJ AF ASHCOM, TL JOHNS, JP BAILEY, SR RUBAL, BJ TI EFFECTS OF CHRONIC BETA-BLOCKADE ON REST AND EXERCISE HEMODYNAMICS IN MITRAL-STENOSIS SO CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS LA English DT Article DE HEART RATE; DIASTOLE; CARDIAC CATHETERIZATION ID SINUS RHYTHM AB beta-blocker therapy for mitral stenosis Is controversial, This study compares right and left heart hemodynamics at rest and supine submaximal exercise in patients (n=7) receiving chronic beta-antagonists with untreated patients (n=17) matched for age (mean +/-SD = 51+/-12 years) and valve area (0.7+/-0.2 cm(2)/m(2)), Little benefit was observed with treatment at rest, Although pulmonary capillary wedge pressures (PCWP) were lower during exercise in the beta-blocker group (22+/-4 vs. 31+/-9 mmHg; P<0.05), exercise performance was not enhanced and cardiac output response during exercise was reduced (control = 41% increase vs, 12% for beta-blockade). PCWP rose rapidly when diastolic filling periods were <300 msec in both groups. Pulmonary capillary wedge pressure was found to be a nonlinear functions (P<0.001) of diastolic filling period (PCWP=15.9+5.84x10(5)/dfp(2)), These data suggest that there is a critical heart rate in patients with mitral stenosis above which hemodynamic compromise rapidly occurs. (C) 1995 Wiley-Liss, Inc. C1 BROOKE ARMY MED CTR, MDC, MCHE, DEPT MED, SERV CARDIOL, FT SAM HOUSTON, TX 78234 USA. NR 16 TC 4 Z9 4 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0098-6569 J9 CATHETER CARDIO DIAG JI Catheter. Cardiovasc. Diagn. PD JUN PY 1995 VL 35 IS 2 BP 110 EP 115 DI 10.1002/ccd.1810350206 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA RB058 UT WOS:A1995RB05800005 PM 7656301 ER PT J AU BERNARDO, JE CIMENT, PR SPEIGHTS, L AF BERNARDO, JE CIMENT, PR SPEIGHTS, L TI REENGINEERING THE LABORATORY FOR INCREASED PRODUCTIVITY USING TOTAL WORKFLOW ANALYSIS SO CLINICAL CHEMISTRY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD JUN PY 1995 VL 41 IS 6 SU S BP S207 EP S207 PG 1 WC Medical Laboratory Technology SC Medical Laboratory Technology GA RD904 UT WOS:A1995RD90400765 ER PT J AU MACARTHY, P DEFRAITES, R HICKS, C TRUSS, S GILSON, K HOKE, C AF MACARTHY, P DEFRAITES, R HICKS, C TRUSS, S GILSON, K HOKE, C TI IMMUNE-RESPONSE TO INACTIVATED HEPATITIS-A VACCINE USING RADIOIMMUNOASSAY AND IMX HAVAB MICROPARTICLE ENZYME-IMMUNOASSAY SO CLINICAL CHEMISTRY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD JUN PY 1995 VL 41 IS 6 SU S BP S76 EP S76 PG 1 WC Medical Laboratory Technology SC Medical Laboratory Technology GA RD904 UT WOS:A1995RD90400192 ER PT J AU SURANA, RB RAFI, SK CHRISTOPHER, KL REID, J WEISS, RB AF SURANA, RB RAFI, SK CHRISTOPHER, KL REID, J WEISS, RB TI CONSTITUTIONAL HETEROMORPHISM OF 9Q13-]Q21 IN A PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA SO CLINICAL GENETICS LA English DT Note DE CHROMOSOME VAR(9)(Q13-]Q21); CHRONIC MYELOGENOUS LEUKEMIA; CONSTITUTIONAL; EUCHROMATIC; GENETIC COUNSELING; HETEROMORPHISM ID EUCHROMATIC BAND; CHROMOSOME-9 VARIANT; EXTRA BAND; 9QH REGION; FAMILY; QH AB Cytogenetic studies were carried out in a 44-year-old white male because of newly diagnosed chronic myelogenous leukemia. His initial bone marrow study revealed 46,XY,var(9)(q13 --> q21)/46,XY,var(9) (q13 --> q21), t(9;22)(q34;q11) karyotypes and later he also acquired a 47,XY,+ 8,var(9)(q13 --> q21), t(9;22)(q34;q11) clone. The var(9)(q13 --> q21) heteromorphism was observed in the normal 9 homolog, in 200 GTG-banded bone marrow metaphases in seven cytogenetic studies (1988-90). This heteromorphism was observed in the normal cell line, in the two chronic myelogenous leukemia-related clones, as well as in 100 mitogen-induced peripheral blood lymphocytes, indicating its constitutional nature. This seems to be the first report of var(9)(q13 --> q21) heteromorphism, involving GTG-positive euchromatic band, in a chronic myelogenous leukemia proband. C1 ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. FU NCI NIH HHS [CA-26806] NR 17 TC 0 Z9 0 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0009-9163 J9 CLIN GENET JI Clin. Genet. PD JUN PY 1995 VL 47 IS 6 BP 321 EP 323 PG 3 WC Genetics & Heredity SC Genetics & Heredity GA RH505 UT WOS:A1995RH50500009 PM 7554367 ER PT J AU ALVING, CR SWARTZ, GM WASSEF, NM HERDERICK, EE VIRMANI, R KOLODGIE, FD MATYAS, GR RIBAS, JL KENNER, JR CORNHILL, JF AF ALVING, CR SWARTZ, GM WASSEF, NM HERDERICK, EE VIRMANI, R KOLODGIE, FD MATYAS, GR RIBAS, JL KENNER, JR CORNHILL, JF TI PROSPECTS FOR AN ANTICHOLESTEROL VACCINE SO CLINICAL IMMUNOTHERAPEUTICS LA English DT Article ID CHOLESTEROL; AUTOANTIBODIES; ANTIBODIES AB It has been discovered that under certain circumstances cholesterol is a highly immunogenic molecule. Surprisingly, naturally occurring antibodies to cholesterol are ubiquitously present, to varying degrees, in all normal human sera. Experimental studies on cholesterol-fed rabbits have demonstrated that diet-induced hypercholesterolaemia and atherosclerosis can be decreased by immunisation with cholesterol-laden liposomes. Antibodies induced by the immunisation procedure appear to bind to lipoproteins of the very low, low and intermediate density classes. Based on this, a vaccine has been proposed for prevention or amelioration of diet-induced hypercholesterolaemia in humans. Phase I trials of the vaccine, which is expected to be safe, are anticipated in the near future in humans. The feasibility of immunological modulation of hypercholesterolaemia and atherosclerosis in humans may be demonstrated with a unique vaccine that targets cholesterol in low density lipoprotein. C1 OHIO STATE UNIV,COLUMBUS,OH 43210. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. CLEVELAND CLIN FDN,CLEVELAND,OH 44195. RP ALVING, CR (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307, USA. NR 26 TC 5 Z9 5 U1 0 U2 0 PU ADIS INTERNATIONAL LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 10, NEW ZEALAND SN 1172-7039 J9 CLIN IMMUNOTHER JI Clin. Immunother. PD JUN PY 1995 VL 3 IS 6 BP 409 EP 414 PG 6 WC Immunology; Pharmacology & Pharmacy SC Immunology; Pharmacology & Pharmacy GA RA679 UT WOS:A1995RA67900001 ER PT J AU HUNT, AC AF HUNT, AC TI TOWARD AND UNFINALIZABLE DIALOGUE, MUSIL,ROBERT ESSAYISM AND BAKHTINIAN DIALOGISM SO COLLEGE LITERATURE LA English DT Article RP HUNT, AC (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU WEST CHESTER UNIV PI W CHESTER PA SPECIAL FUNDS OFFICE, W CHESTER, PA 19383 SN 0093-3139 J9 COLL LITERATURE JI Coll. Lit. PD JUN PY 1995 VL 22 IS 2 BP 116 EP 124 PG 9 WC Literature SC Literature GA RJ413 UT WOS:A1995RJ41300007 ER PT J AU LEVINE, M DUFFY, L MOORE, DC MATEJ, LA AF LEVINE, M DUFFY, L MOORE, DC MATEJ, LA TI ACCLIMATION OF A NON-INDIGENOUS SUB-ARCTIC POPULATION - SEASONAL-VARIATION IN THYROID-FUNCTION IN INTERIOR ALASKA SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY LA English DT Article DE THYROID; SEASONAL; ACCLIMATION ALASKA; T3 (TRIIODOTHYRONINE); T4 (THYROXINE); MELATONIN; DIURNAL ID SYRIAN-HAMSTERS; MELATONIN; COLD; ENVIRONMENT; HORMONE; AXIS AB Total, as well as free, T4 and T3 levels were obtained over four seasons for young male infantry soldiers assigned to interior Alaska. Significant seasonal variations were found in both T3 and T4. Total T4 and T3 levels were highest in winter, while free T4 and T3 levels were highest in early spring. Correlations with melatonin levels from a concurrent study showed an association between late day (17.00) mean spot melatonin levels during the preceding summer and T3 levels in winter and spring. Differences in seasonal T4 and T3 levels between indigenous and newly arrived people in the sub-Arctic may be related not only to cold acclimation but also to light. C1 UNIV ALASKA,INST ARCTIC BIOL,FAIRBANKS,AK 99775. BROOKE ARMY MED CTR,DEPT PSYCHIAT,FT SAM HOUSTON,TX 78234. UNIV ALASKA,DEPT CHEM,FAIRBANKS,AK 99775. MADIGAN ARMY MED CTR,TACOMA,WA 98431. NR 30 TC 18 Z9 20 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0300-9629 J9 COMP BIOCHEM PHYS A JI Comp. Biochem. Physiol. A-Physiol. PD JUN PY 1995 VL 111 IS 2 BP 209 EP 214 DI 10.1016/0300-9629(95)00016-Z PG 6 WC Biochemistry & Molecular Biology; Physiology; Zoology SC Biochemistry & Molecular Biology; Physiology; Zoology GA RC112 UT WOS:A1995RC11200004 PM 7788348 ER PT J AU FEIGL, P BLUMENSTEIN, B THOMPSON, I CROWLEY, J WOLF, M KRAMER, BS COLTMAN, CA BRAWLEY, OW FORD, LG AF FEIGL, P BLUMENSTEIN, B THOMPSON, I CROWLEY, J WOLF, M KRAMER, BS COLTMAN, CA BRAWLEY, OW FORD, LG TI DESIGN OF THE PROSTATE-CANCER PREVENTION TRIAL (PCPT) SO CONTROLLED CLINICAL TRIALS LA English DT Article DE CHEMOPREVENTION; PROSTATE CANCER; MONITORING TECHNIQUES; BIASED ASCERTAINMENT ID DIGITAL RECTAL EXAMINATION; ANTIGEN; MEN; HYPERPLASIA; FINASTERIDE; MANAGEMENT; OUTCOMES; WHITE AB The PCPT is a chemoprevention trial of finasteride with a primary endpoint of biopsy-proven presence or absence of prostate cancer. A total of 18,000 healthy men, aged 55 years and older, will be randomized. Half will receive finasteride (5 mg/day) and half will receive placebo (one matching tablet per day) for 7 years. The trial is designed to have 92% power to detect a 25% reduction in period prevalence of biopsy-proven disease using a two-sided test with alpha = 0.05. The trial is complicated by the known impact of finasteride on the major screening test for prostate cancer, prostate specific antigen (PSA). This paper describes the PCPT design with reference to alternatives that were considered. The chosen design depends on five critical assumptions that must be monitored closely throughout the 9-year trial. C1 BROOKE ARMY MED CTR,DEPT SURG,UROL SERV,FT SAM HOUSTON,TX 78234. NATL CANC INST,DIV CANC PREVENT & CONTROL,BETHESDA,MD. SW ONCOL GRP,OPERAT OFF,SAN ANTONIO,TX. SAN ANTONIO CANC INST,SAN ANTONIO,TX. RP FEIGL, P (reprint author), FRED HUTCHINSON CANC RES CTR,CTR STAT,SW ONCOL GRP,1124 COLUMBIA ST,SEATTLE,WA 98104, USA. FU NCI NIH HHS [2 U10 CA37429-09, 5 U10 CA37429] NR 32 TC 106 Z9 107 U1 1 U2 2 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0197-2456 J9 CONTROL CLIN TRIALS JI Controlled Clin. Trials PD JUN PY 1995 VL 16 IS 3 BP 150 EP 163 DI 10.1016/0197-2456(94)00XXX-M PG 14 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA QR790 UT WOS:A1995QR79000003 PM 7540965 ER PT J AU WELCH, M SMITH, KJ SKELTON, HG TURIANSKY, G FRISMAN, D WAGNER, KF AF WELCH, M SMITH, KJ SKELTON, HG TURIANSKY, G FRISMAN, D WAGNER, KF TI INFLAMMATORY LINEAR VERRUCOUS EPIDERMAL NEVUS IN PATIENTS WITH POSITIVE RESULTS OF TESTS FOR HUMAN-IMMUNODEFICIENCY-VIRUS-1 SO CUTIS LA English DT Article ID REITERS-SYNDROME; PSORIASIS; INFECTION; CELLS AB Inflammatory linear verrucous epidermal nevi are rare lesions that have many similarities to psoriasis on histologic examination, and are resistant to therapy. The two lesions reported occurred in patients with positive results of tests for human immunodeficiency virus 1 and showed features consistent with psoriasis. Results of tests for immunohistochemical markers were also consistent with previous findings and expected staining patterns in lesions of psoriasis. Our findings suggest that inflammatory linear verrucous epidermal nevi represent a clonal dysregulation in growth, probably secondary to an inflammatory stimulus. Since human immunodeficiency virus 1 has been associated with onset and exacerbation of psoriasis, perhaps this virus or another secondary infection associated with human immunodeficiency virus 1 infection could also play a role in the onset of this rare lesion. C1 ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. HENRY M JACKSON FDN,BETHESDA,MD. RP WELCH, M (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU EXCERPTA MEDICA INC PI BELLE MEAD PA 105 RAIDER BLVD, BELLE MEAD, NJ 08502 SN 0011-4162 J9 CUTIS JI Cutis PD JUN PY 1995 VL 55 IS 6 BP 365 EP 368 PG 4 WC Dermatology SC Dermatology GA RB492 UT WOS:A1995RB49200010 PM 7648889 ER PT J AU KEPCZYK, MT KADAKIA, CSC AF KEPCZYK, MT KADAKIA, CSC TI PROSPECTIVE EVALUATION OF GASTROINTESTINAL-TRACT IN PATIENTS WITH IRON-DEFICIENCY ANEMIA SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE IRON-DEFICIENCY ANEMIA; GASTROINTESTINAL BLEEDING; CELIAC DISEASE; GASTROINTESTINAL ENDOSCOPY; ENTEROCLYSIS ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; COLONOSCOPIC EVALUATION; UPPER ENDOSCOPY; BLOOD-LOSS; ANGIODYSPLASIA; DIAGNOSIS; HEMORRHOIDS; MANAGEMENT; POPULATION; DISEASE AB Gastrointestinal bleeding is believed to cause iron-deficiency anemia (IDA). The information concerning ideal evaluation of the gastrointestinal tract and exact findings in patients with IDA is scant. The aim of this study was to prospectively evaluate patients with IDA for gastrointestinal lesions potentially causing IDA at a US Army Teaching Medical Center with Gastroenterology Fellowship. Seventy patients with IDA had esophagogastroduodenoscopy (EGD) and colonoscopy, and if this evaluation was unremarkable, then small bowel biopsy was obtained at EGD to evaluate for celiac disease. Enteroclysis was done if endoscopic evaluation was negative. At. endoscopy, at least one lesion potentially accounted for the IDA in 50 (71%) patients. At colonoscopy, 21 (30%) patients had 22 lesions (four colon cancer, seven adenoma > 1 cm, six vascular malformation, four severely bleeding hemorrhoids, one ileal Crohn's); at EGD, 39 (56%) patients had 43 lesions (11 gastric erosion, 10 esophagitis, four vascular malformation, four celiac disease, three gastric cancer, three gastric ulcer, three duodenal, ulcer, two gastric polyp > 1 cm, one duodenal lymphoma, one esophageal cancer, and One duodenal Crohn's). Twelve (17%) patients had both upper and lower gastrointestinal tract lesions. Twenty-four of 32 (75%) patients with positive fecal occult blood test had potentially bleeding lesions compared to 24 of 38 (63%) patients with negative fecal Occult blood test (P > 0.05). Six of nine patients with malignancy had positive fecal occult blood test. Twenty patients with normal endoscopy and small bowel biopsy had normal enteroclysis. It is Is concluded that the combination of colonoscopy and EGD identifies potential bleeding sources in most patients with IDA. In the absence of a potential bleeding lesion, small bowel biopsy at EGD is essential to diagnose celiac disease. C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 39 TC 109 Z9 109 U1 0 U2 1 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD JUN PY 1995 VL 40 IS 6 BP 1283 EP 1289 DI 10.1007/BF02065539 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA RE070 UT WOS:A1995RE07000021 PM 7781448 ER PT J AU WESENSTEN, NJ BALKIN, TJ BELENKY, GL AF WESENSTEN, NJ BALKIN, TJ BELENKY, GL TI EFFECTS OF DAYTIME ADMINISTRATION OF ZOLPIDEM VERSUS TRIAZOLAM ON MEMORY SO EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article DE TRIAZOLAM; ZOLPIDEM; MEMORY; HYPNOTIC EFFICACY, SLEEP ID PSYCHOMOTOR PERFORMANCE; HEALTHY-SUBJECTS; SLEEP AB To determine whether zolpidem (an imidazopyridine hypnotic) produces amnestic effects which are similar to those produced by triazolam (a benzodiazepine hypnotic), 70 subjects were adminstered either triazolam (0.125, 0.25, or 0.5 mg), zolpidem (5, 10 or 15 mg) or placebo, then tested on Simulated Escape, Restricted Reminding, and Paired-Associates memory tests at 1.5 hours post-dosing (i.e., near the time of estimated peak blood concentration for both drugs) and again at 6 hours post-dosing. Triazolam 0.5 mg produced the greatest memory impairment at both test times, and also produced the greatest degree of sedation during intervening daytime naps in a non-sleep-conducive environment. Other doses of triazolam and zolpidem produced less memory impairment, but also failed to significantly enhance sleep. The results are consistent with the view that the amnestic and hypnotic effects of these sleep-inducing medications are functionally coupled. RP WESENSTEN, NJ (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BEHAV BIOL,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 29 TC 37 Z9 37 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0031-6970 J9 EUR J CLIN PHARMACOL JI Eur. J. Clin. Pharmacol. PD JUN PY 1995 VL 48 IS 2 BP 115 EP 122 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA RJ750 UT WOS:A1995RJ75000005 PM 7589024 ER PT J AU KAMIMORI, GH EDDINGTON, ND HOYT, RW FULCO, CS LUGO, S DURKOT, MJ BRUNHART, AE CYMERMAN, A AF KAMIMORI, GH EDDINGTON, ND HOYT, RW FULCO, CS LUGO, S DURKOT, MJ BRUNHART, AE CYMERMAN, A TI EFFECTS OF ALTITUDE (4300 M) ON THE PHARMACOKINETICS OF CAFFEINE AND CARDIO-GREEN IN HUMANS SO EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article DE CAFFEINE; CARDIO-GREEN; INDOCYANINE GREEN, ALTITUDE, METABOLISM, PHARMACOKINETICS, HYPOXIA ID HEPATIC BLOOD-FLOW; INDOCYANINE GREEN; DISPOSITION; EXERCISE; HYPOXIA AB The effects of chronic exposure to high altitude on the pharmacokinetics of caffeine and cardiogreen (ICG) were examined in eight healthy males (23-35 y) at sea level (SEA) and following 16 days residence at 4300 m (ALT). ICG (0.5 mg . kg(-1)) was administered as an intravenous bolus and caffeine (4 mg . kg(-1)) in an orally ingested solution. The concentration of ICG, caffeine, and the primary metabolites of caffeine (MET) were determined in serial blood samples and their pharmacokinetics computed. In comparison to SEA, ALT resulted in a significant decrease in the caffeine half-life (t(1/2), 4.7 vs 6.7 h) and area under the curve (2.5 vs 3.7 g l(-1) min(-1)), and increased clearance (117 vs 86 ml . min(-1) 70 kg(-1)). In ALT the area under the curve of ICG significantly decreased (85 vs 207 mg . l(-1). min(-1)) and the volume of distribution and clearance increased (5.2 vs 2.41 and 532 vs 234 ml . min(-1) respectively) compared to SEA. There was a significant increase in the AUC ratio of MET to caffeine indicating that either metabolite formation or elimination was increased in ALT. These results demonstrate that in humans, chronic exposure to 4300 m results in the modification of the pharmacokinetics of caffeine and ICG. C1 UNIV MARYLAND,DEPT PHARMACEUT,PHARMACOKINET BIOPHARMACEUT LABS,BALTIMORE,MD 20210. USA,ENVIRONM MED RES INST,DIV ALTITUDE PHYSIOL & MED,NATICK,MA 01760. RP KAMIMORI, GH (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BEHAV BIOL,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 22 TC 14 Z9 15 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0031-6970 J9 EUR J CLIN PHARMACOL JI Eur. J. Clin. Pharmacol. PD JUN PY 1995 VL 48 IS 2 BP 167 EP 170 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA RJ750 UT WOS:A1995RJ75000014 PM 7589033 ER PT J AU BROTMAN, M GIANNELLA, RA ALM, PF BAUMAN, H BENNETT, AR BLACK, RE BRUHN, CM COHEN, MB GORBACH, SL KAPER, JB ROBERTS, MR STANECK, JL TAYLOR, S TROUTT, HF BELL, BP BUCHANAN, RL DURHAM, K FENG, P FORMAN, CT GALLER, RG GRAVANI, RB HALL, RB HANCOCK, DD HOLLINGSWORTH, J KARMALI, MA KEUSCH, GT MARSDEN, JL OSTERHOLM, MT REAGAN, JO ROBERTS, T SIEGLER, RL SWERDLOW, DL TARR, PI COWMAN, GL GOODFELLOW, SJ GRIFFIN, PM HALL, M HAMILTON, F HARRINGTON, RE KARR, KJ LANG, DR MADDEN, JM NORCROSS, MA SAVAGE, K SHANK, F TAYLOR, DN AF BROTMAN, M GIANNELLA, RA ALM, PF BAUMAN, H BENNETT, AR BLACK, RE BRUHN, CM COHEN, MB GORBACH, SL KAPER, JB ROBERTS, MR STANECK, JL TAYLOR, S TROUTT, HF BELL, BP BUCHANAN, RL DURHAM, K FENG, P FORMAN, CT GALLER, RG GRAVANI, RB HALL, RB HANCOCK, DD HOLLINGSWORTH, J KARMALI, MA KEUSCH, GT MARSDEN, JL OSTERHOLM, MT REAGAN, JO ROBERTS, T SIEGLER, RL SWERDLOW, DL TARR, PI COWMAN, GL GOODFELLOW, SJ GRIFFIN, PM HALL, M HAMILTON, F HARRINGTON, RE KARR, KJ LANG, DR MADDEN, JM NORCROSS, MA SAVAGE, K SHANK, F TAYLOR, DN TI CONSENSUS CONFERENCE STATEMENT - ESCHERICHIA-COLI O157-H7 INFECTIONS - AN EMERGING NATIONAL-HEALTH CRISIS, JULY 11-13, 1994 SO GASTROENTEROLOGY LA English DT Editorial Material ID HEMOLYTIC-UREMIC SYNDROME; HEMORRHAGIC COLITIS; 0157-H7; TOXIN; EPIDEMIOLOGY; PATHOGEN; DIARRHEA; CULTURES AB This statement was prepared by a nonadvocate panel of experts based an (1) presentations by investigators working in areas relevant to the consensus questions during a 2-day public session, (2) questions and statements from conference attendees during open discussion periods that are part of the public session, and (3) closed deliberations by the panel during the remainder of the second dat and the morning of the third. This statement is an independent report of the panel and is not a policy statement of the American Gastroenterological Association, the American Gastroenterological Association Foundation (now known as the American Digestive Health Foundation) or the cosponsors listed at the end at this statement. C1 CALIF PACIFIC MED CTR,DEPT MED,SAN FRANCISCO,CA. UNIV CINCINNATI,COLL MED,DEPT INTERNAL MED,DIV DIGEST DIS,CINCINNATI,OH 45267. ALM CONSULTING SERV,SAN ANTONIO,TX. FOX BENNETT & TURNER,WASHINGTON,DC. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT INT HLTH,BALTIMORE,MD. UNIV CALIF DAVIS,CTR CONSUMER RES,DAVIS,CA. CHILDRENS HOSP,MED CTR,DIV PEDIAT GASTROENTEROL & NUTR,CINCINNATI,OH 45229. TUFTS UNIV,SCH MED,BOSTON,MA 02111. UNIV MARYLAND,SCH MED,CTR VACCINE DEV,DEPT MED,BALTIMORE,MD 21201. FLORIDA DEPT AGR & CONSUMER SERV,TALLAHASSEE,FL. UNIV CINCINNATI HOSP,DEPT PATHOL & LAB MED,CINCINNATI,OH. UNIV NEBRASKA,DEPT FOOD SCI & TECHNOL,LINCOLN,NE 68583. UNIV ILLINOIS,DEPT VET CLIN MED,URBANA,IL 61801. WASHINGTON DEPT HLTH,CTR DIS CONTROL & PREVENT,SEATTLE,WA. USDA ARS,EASTERN REG RES CTR,MICROBIAL FOOD SAFETY RES UNIT,PHILADELPHIA,PA 19118. US FDA,CTR FOOD SAFETY & APPL NUTR,OFF CONSTITUENT OPERAT,WASHINGTON,DC 20204. US FDA,CTR FOOD SAFETY & APPL NUTR,DIV MICROBIOL STUDIES,WASHINGTON,DC 20204. FOREMAN & HEIDEPRIEM INC,WASHINGTON,DC. LOIS JOY GALLER FDN HEMOLYT UREM SYNDROME INC,VALLEY STREAM,NY. CORNELL UNIV,INST FOOD SCI,DEPT FOOD SCI,DIV FOOD SAFETY EXTENS,ITHACA,NY 14853. US FDA,CTR FOOD SAFETY & APPL NUTR,DIV VIRULENCE ASSESSMENT,WASHINGTON,DC 20204. DEPT VET CLIN SCI,FIELD DIS INVEST UNIT,PULLMAN,WA. USDA,FOOD SAFETY & INSPECT SERV,WASHINGTON,DC 20250. HOSP SICK CHILDREN,DEPT MICROBIOL,TORONTO,ON M5G 1X8,CANADA. TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED,DIV GEOG MED & INFECT DIS,BOSTON,MA 02111. AMI FDN,AMER MEAT INST,ARLINGTON,VA. MINNESOTA DEPT HLTH,ACUTE DIS & EPIDEMIOL SECT,MINNEAPOLIS,MN. NATL LIVE STEOCK & MEAT BOARD,DEPT RES MEAT SCI,DIV PROD TECHNOL,CHICAGO,IL. USDA,DIV ECON RES SERV,FOOD SAFETY & REGULAT SECT,WASHINGTON,DC 20250. UNIV UTAH,SCH MED,DEPT PEDIAT,DIV NEPHROL,SALT LAKE CITY,UT. CTR DIS CONTROL & PREVENT,FOODBORNE & DIARRHEAL DIS BRANCH,DIV BACTERIAL & MYCOT DIS,ATLANTA,GA 30341. UNIV WASHINGTON,CHILDRENS HOSP & MED CTR,DEPT PEDIAT,DIV GASTROENTEROL,SEATTLE,WA. UNIV CINCINNATI,COLL MED,DEPT INTERNAL MED,DIV DIGEST DIS,CINCINNATI,OH 45267. CALIF PACIFIC MED CTR,DEPT MED,SAN FRANCISCO,CA. NATL CATTLEMENS ASSOC,ENGLEWOOD,CO. ABC RES CORP,DEPT MICROBIOL,GAINESVILLE,FL. CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV BACTERIAL & MYCOT DIS,ATLANTA,GA. AMER GASTROENTEROL ASSOC FDN,BETHESDA,MD. NIDDKD,DIV DIGEST DIS & NUTR,BETHESDA,MD 20892. NATL RESTAURANT ASSOC,TECH SERV,WASHINGTON,DC. NIAID,DIV MICROBIOL & INFECT DIS,BETHESDA,MD 20892. FOOD MKT INST,WASHINGTON,DC. US FDA,CTR FOOD SAFETY & APPL NUTR,WASHINGTON,DC 20204. WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC. NR 55 TC 39 Z9 39 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD JUN PY 1995 VL 108 IS 6 BP 1923 EP 1934 PG 12 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA RA378 UT WOS:A1995RA37800040 ER PT J AU LEE, M KUBIK, CM POLHAMUS, CD BRADY, CE KADAKIA, SC AF LEE, M KUBIK, CM POLHAMUS, CD BRADY, CE KADAKIA, SC TI PRELIMINARY EXPERIENCE WITH ENDOSCOPIC INTRALESIONAL STEROID INJECTION THERAPY FOR REFRACTORY UPPER GASTROINTESTINAL STRICTURES SO GASTROINTESTINAL ENDOSCOPY LA English DT Note ID ESOPHAGEAL STRICTURES; DILATATION C1 BROOKE ARMY MED CTR,SAN ANTONIO,TX. RP LEE, M (reprint author), UNIV TEXAS,HLTH SCI CTR,WILFORD HALL MED CTR,DIV GASTROENTEROL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. NR 16 TC 70 Z9 72 U1 0 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD JUN PY 1995 VL 41 IS 6 BP 598 EP 601 DI 10.1016/S0016-5107(95)70199-0 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA RD417 UT WOS:A1995RD41700014 PM 7672557 ER PT J AU AITCHESON, SJ HARMON, RS MOORBATH, S SCHNEIDER, A SOLER, P SORIAESCALANTE, E STEELE, G SWAINBANK, I WORNER, G AF AITCHESON, SJ HARMON, RS MOORBATH, S SCHNEIDER, A SOLER, P SORIAESCALANTE, E STEELE, G SWAINBANK, I WORNER, G TI PB ISOTOPES DEFINE BASEMENT DOMAINS OF THE ALTIPLANO, CENTRAL ANDES SO GEOLOGY LA English DT Article ID LEAD; ROCKS; MAGMATISM; CHILE AB Detailed Pb isotopic maps of the central Andes, based on 345 (163 previously published, 182 new) analyses of ores, volcanic rocks, and their host rocks, elucidate the gross structure of the basement and reveal that several isotopically distinct basement domains are juxtaposed in this region. The data clearly show that most of the Pb in central Andean igneous and ore samples is derived from the local basement, including Pb in ore deposits of the Bolivian tin belt. Some of the isotopic domain boundaries correspond to geologic structures and the residual gravity pattern, as well as to metallogenic boundaries such as the western edge of the Bolivian tin belt. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. TVX GOLD,SANTIAGO,CHILE. ORSTOM,DEPT TERRE OCEAN ATMOSPHERE,F-75480 PARIS 10,FRANCE. EMICRUZ COMSUR RTZ JV,LA PAZ,BOLIVIA. NERC,ISOTOPE GEOSCI LAB,KEYWORTH NG12 5GG,NOTTS,ENGLAND. UNIV GOTTINGEN,INST GEOCHEM,D-37077 GOTTINGEN,GERMANY. RP AITCHESON, SJ (reprint author), UNIV OXFORD,DEPT EARTH SCI,PARKS RD,OXFORD OX1 3PR,ENGLAND. NR 21 TC 66 Z9 71 U1 4 U2 6 PU GEOLOGICAL SOC AMERICA PI BOULDER PA PO BOX 9140 3300 PENROSE PLACE, BOULDER, CO 80301 SN 0091-7613 J9 GEOLOGY JI Geology PD JUN PY 1995 VL 23 IS 6 BP 555 EP 558 DI 10.1130/0091-7613(1995)023<0555:PIDBDO>2.3.CO;2 PG 4 WC Geology SC Geology GA RB222 UT WOS:A1995RB22200019 ER PT J AU PEROVICH, DK AF PEROVICH, DK TI OBSERVATIONS OF ULTRAVIOLET-LIGHT REFLECTION AND TRANSMISSION BY FIRST-YEAR SEA-ICE SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID MICROBIAL COMMUNITIES; OZONE DEPLETION; ANTARCTICA; ABUNDANCE; RADIATION AB As part of a comprehensive program investigating the electromagnetic properties of sea ice, measurements were made of the optical properties of young ice and first-year sea ice at ultraviolet wavelengths. Young sea ice observations were made in a specially designed sea ice pond at the Cold Regions Research and Engineering Laboratory (Hanover, NH), while first-year sea ice was examined in the Chukchi Sea and Beaufort Sea near Barrow, Alaska, The results indicated that, in general, albedo increased with increasing wavelength from 305 to 380 nm, with values for first-year ice in the 0.4 to 0.6 range. Transmittance through bare first-year ice was roughly 0.5 to 2 percent. Extinction coefficients for bare sea ice were between 2 and 4 m(-1) and decreased with increasing wavelength. The presence df a snow cover had a profound impact on ultraviolet light levels under sea ice, with even a thin (0.1-m-thick) snow cover reducing transmitted ultraviolet light by more than an order of magnitude. Observed transmittances indicated that the attenuation of ultraviolet light by sea ice and snow was greater than that of the photosynthetically active radiation. RP PEROVICH, DK (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 19 TC 8 Z9 8 U1 1 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD JUN 1 PY 1995 VL 22 IS 11 BP 1349 EP 1352 DI 10.1029/95GL01062 PG 4 WC Geosciences, Multidisciplinary SC Geology GA RB550 UT WOS:A1995RB55000009 ER PT J AU MCKAY, DJ MORSE, JS AF MCKAY, DJ MORSE, JS TI PERFORMANCE CHARACTERIZATION OF A LABORATORY-SCALE BIOREACTOR WITH LIQUID SUSPENSIONS OF ALCALIGENES-EUTROPHUS JMP134 SO HAZARDOUS WASTE & HAZARDOUS MATERIALS LA English DT Article AB Trichloroethylene (TCE) was degraded in a single-stage, continuously stirred tank reactor (CSTR) bioreactor containing pure cultures of liquid-dispersed Alcaligenes eutrophus JMP134. Phenol was supplied as the sole source of carbon and energy for induction of catabolic activities. Operating conditions were varied in a series of randomly ordered experiments. The independent variables were influent TCE concentration, influent phenol concentration, and hydraulic residence time. The dependent variable was the percent of influent TCE degraded or degradation efficiency. The highest degradation efficiency observed was 98.6%. An empirical equation was fitted to the data in the form of degradation efficiency as a function of the three independent variables. A close match was achieved between the equation and the data. This equation is valid only where the phenol was oxidized below the level of detection in the effluent (150 mu g/L). This equation is useful for bioreactor design and operation. Hydraulic residence time was noted to have a relatively small effect on degradation efficiency. Phenol and TCE were competitive, as expected in a cometabolism system. The implication for bioreactor operation is that phenol levels must be closely matched to TCE levels for optimum performance. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0882-5696 J9 HAZARD WASTE HAZARD JI Hazard. Waste Hazard. Mater. PD SUM PY 1995 VL 12 IS 3 BP 185 EP 196 PG 12 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA TE086 UT WOS:A1995TE08600001 ER PT J AU DOUGHT, RA AF DOUGHT, RA TI NAPOLEON LAST VICTORY AND THE EMERGENCE OF MODERN WAR - EPSTEIN,RM SO HISTORIAN LA English DT Book Review RP DOUGHT, RA (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU PHI ALPHA THETA PI ALLENTOWN PA THE HISTORIAN 2333 LIBERTY STREET, ALLENTOWN, PA 18104 SN 0018-2370 J9 HISTORIAN JI Historian PD SUM PY 1995 VL 57 IS 4 BP 827 EP 828 PG 2 WC History SC History GA RN918 UT WOS:A1995RN91800056 ER PT J AU CAVALERI, DP AF CAVALERI, DP TI MASSACRES - AN HISTORICAL-PERSPECTIVE - CARLTON,E SO HISTORIAN LA English DT Book Review RP CAVALERI, DP (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU PHI ALPHA THETA PI ALLENTOWN PA THE HISTORIAN 2333 LIBERTY STREET, ALLENTOWN, PA 18104 SN 0018-2370 J9 HISTORIAN JI Historian PD SUM PY 1995 VL 57 IS 4 BP 850 EP 850 PG 1 WC History SC History GA RN918 UT WOS:A1995RN91800079 ER PT J AU HAMLEN, RP CHRISTOPHER, HA GILMAN, S AF HAMLEN, RP CHRISTOPHER, HA GILMAN, S TI US ARMY BATTERY NEEDS - PRESENT AND FUTURE SO IEEE AEROSPACE AND ELECTRONIC SYSTEMS MAGAZINE LA English DT Article RP HAMLEN, RP (reprint author), USA,RES LAB,DIV POWER SOURCES,BATTERY DEV & ENGN BRANCH,FT MONMOUTH,NJ 07703, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-8985 J9 IEEE AERO EL SYS MAG JI IEEE Aerosp. Electron. Syst. Mag. PD JUN PY 1995 VL 10 IS 6 BP 30 EP 33 DI 10.1109/62.387975 PG 4 WC Engineering, Aerospace; Engineering, Electrical & Electronic SC Engineering GA RC442 UT WOS:A1995RC44200008 ER PT J AU JONES, JR TAIT, GB JONES, SH KATZER, DS AF JONES, JR TAIT, GB JONES, SH KATZER, DS TI DC AND LARGE-SIGNAL TIME-DEPENDENT ELECTRON-TRANSPORT IN HETEROSTRUCTURE DEVICES - AN INVESTIGATION OF THE HETEROSTRUCTURE BARRIER VARACTOR SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article ID RAY PHOTOEMISSION SPECTROSCOPY; HETEROJUNCTION BAND OFFSETS; SUBMILLIMETER-WAVE POWER; MILLIMETER-WAVE; CYCLOTRON-RESONANCE; MATERIAL PARAMETERS; NUMERICAL-ANALYSIS; BOUNDARY-CONDITION; INP; DIODES AB The de and large-signal time-dependent electron transport properties of Heterostructure Barrier Varactors () are investigated using a physical model which combines drift-diffusion current transport through the heterostructure bulk with thermionic and thermionic-field emission currents imposed at the abrupt heterointerfaces in a fully self-consistent manner. A fast and accurate hydrodynamic device simulator for generic unipolar InGaAs/InAlAs on InP, InGaAs/InP on InP, and GaAs/InGaAs/AlGaAs on GaAs has been developed based on this model, The experimentally observed current-voltage and capacitance-voltage characteristics of GaAs/AlGaAs and GaAs/InGaAs/AlGaAs are compared with the simulated results over a wide range of de bias, Large-signal time-dependent simulations at a pump frequency of 100 GHz confirm the odd-harmonic operation of these devices and indicate that multiple barrier should provide efficient frequency multiplication, especially in high order frequency multipliers, broadband frequency triplers, and quasi-optical tripler arrays. C1 US MIL ACAD,DEPT ELECT ENGN & COMP SCI,W POINT,NY 10996. USN,RES LAB,DIV ELECTR SCI & TECHNOL,WASHINGTON,DC 20375. RP JONES, JR (reprint author), UNIV VIRGINIA,DEPT ELECT ENGN,CHARLOTTESVILLE,VA 22903, USA. RI Katzer, D. Scott/N-7841-2013 NR 48 TC 6 Z9 6 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD JUN PY 1995 VL 42 IS 6 BP 1070 EP 1080 DI 10.1109/16.387239 PG 11 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA QZ200 UT WOS:A1995QZ20000008 ER PT J AU ALVING, CR KOULCHIN, V GLENN, GM RAO, M AF ALVING, CR KOULCHIN, V GLENN, GM RAO, M TI LIPOSOMES AS CARRIERS OF PEPTIDE ANTIGENS - INDUCTION OF ANTIBODIES AND CYTOTOXIC T-LYMPHOCYTES TO CONJUGATED AND UNCONJUGATED PEPTIDES SO IMMUNOLOGICAL REVIEWS LA English DT Review ID MALARIA SPOROZOITE ANTIGEN; FREE SYNTHETIC PEPTIDE; HERPES-SIMPLEX VIRUS; B SURFACE-ANTIGEN; LIPID-A; PLASMODIUM-FALCIPARUM; CIRCUMSPOROZOITE PROTEIN; MONOCLONAL-ANTIBODIES; ALUMINUM HYDROXIDE; RHESUS-MONKEYS C1 MEDIMMUNE INC,GAITHERSBURG,MD 20878. RP ALVING, CR (reprint author), WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307, USA. NR 90 TC 105 Z9 107 U1 0 U2 7 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0105-2896 J9 IMMUNOL REV JI Immunol. Rev. PD JUN PY 1995 VL 145 BP 5 EP 31 DI 10.1111/j.1600-065X.1995.tb00075.x PG 27 WC Immunology SC Immunology GA RK297 UT WOS:A1995RK29700001 PM 7590830 ER PT J AU MALLETT, CP HALE, TL KAMINSKI, RW LARSEN, T ORR, N COHEN, D LOWELL, GH AF MALLETT, CP HALE, TL KAMINSKI, RW LARSEN, T ORR, N COHEN, D LOWELL, GH TI INTRANASAL OR INTRAGASTRIC IMMUNIZATION WITH PROTEOSOME-SHIGELLA LIPOPOLYSACCHARIDE VACCINES PROTECTS AGAINST LETHAL PNEUMONIA IN A MURINE MODEL OF SHIGELLA INFECTION SO INFECTION AND IMMUNITY LA English DT Note ID ANTI-BACTERIAL ACTIVITY; ORAL IMMUNIZATION; FILAMENTOUS HEMAGGLUTININ; RESPIRATORY-INFECTION; SERUM ANTIBODIES; EFFICACY; SONNEI; CELLS; IGA; IMMUNOGENICITY AB Mice immunized intranasally or intragastrically with proteosome vaccines containing either Shigella sonnei or S. flexneri 2a lipopolysaccharide were protected against lethal pneumonia caused by homologous organisms in an experimental murine intranasal challenge model of Shigella infection. Histopathological analysis demonstrated that immunization also protected against the progressive lesions resulting from invasion of the pulmonary mucosa by S. sonnei. These data show that mucosal proteosome-lipopolysaccharide vaccines can protect against lethal bacterial pneumonia and indicate that such vaccines are promising candidates for protection against intestinal shigellosis. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PATHOL,HEADQUARTERS RES BRANCH,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT COMPARAT PATHOL,WASHINGTON,DC 20307. PHARMOS INC,NEW YORK,NY 10022. ISRAEL DEF FORCES MED CORPS,IL-02149 MIL POST,ISRAEL. RP MALLETT, CP (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTER INFECT,BLDG 40,ROOM 2057,WASHINGTON,DC 20307, USA. NR 39 TC 66 Z9 68 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 1995 VL 63 IS 6 BP 2382 EP 2386 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA RA191 UT WOS:A1995RA19100047 PM 7768627 ER PT J AU LINDSTROM, J SMITH, KJ SKELTON, HG REDFIELD, R ALVING, BM WAGNER, KF LUPTON, GP AF LINDSTROM, J SMITH, KJ SKELTON, HG REDFIELD, R ALVING, BM WAGNER, KF LUPTON, GP TI INCREASED ANTICARDIOLIPIN ANTIBODIES ASSOCIATED WITH THE DEVELOPMENT OF ANETODERMA IN HIV-1 DISEASE SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID ACQUIRED IMMUNODEFICIENCY SYNDROME; TUMOR NECROSIS FACTOR; FACTOR-XIIIA; HISTOPATHOLOGIC FINDINGS; PLASMINOGEN-ACTIVATOR; LUPUS ANTICOAGULANT; DERMAL DENDROCYTES; VIRUS INFECTION; AIDS; LIVER AB Background and Objective. Anetoderma has been reported in patients with HIV-1 disease. In patients with autoimmune disease, anetoderma has been associated with increased levels of antiphospholipid antibodies (APL) that include anticardiolipin antibodies (ACA) and lupus anticoagulant (LA). This has led to speculation that the autoimmune phenomena seen in HIV-1 disease and the immune dysregulation induced by HIV-1 disease may play a role in the development of these lesions. We have seen both primary and secondary lesions of anetoderma in patients followed for HIV-1 disease. In this study, we wanted to determine whether there was an association in the development of anetoderma and elevated anticardiolipin antibodies (ACA) in HIV-1 patients. Methods. Quantitative ACA levels were measured in eight HIV-1-infected patients with anetoderma and four HIV-1-infected patients without anetoderma. Results. Anticardiolipin antibodies were moderately elevated in seven of eight patients with lesions and were borderline in the four HIV-1-positive patients without lesions of anetoderma. Conclusions. There appears to be a correlation between increased ACA and the development of cutaneous lesions of anetoderma in HIV-1 disease. Patterns of immune dysregula-tion, including APL, may predispose to the development of lesions of anetoderma in HIV-1-positive patients. Although some of the lesions appear to represent primary anetoderma, the majority of our patients develop lesions in areas secondary to well characterized eruptions. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. HENRY M JACKSON FDN,WASHINGTON,DC. WALTER REED ARMY INST RES,WASHINGTON,DC. WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. NR 41 TC 19 Z9 20 U1 0 U2 0 PU DECKER PERIODICALS INC PI HAMILTON PA 4 HUGHSON ST, PO BOX 620, LCD 1, HAMILTON ON L8N 3K7, CANADA SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD JUN PY 1995 VL 34 IS 6 BP 408 EP 415 DI 10.1111/j.1365-4362.1995.tb04442.x PG 8 WC Dermatology SC Dermatology GA RB897 UT WOS:A1995RB89700009 PM 7657440 ER PT J AU PHELPS, JY GEHLBACH, D AF PHELPS, JY GEHLBACH, D TI TUBOPERITONEAL FISTULA AFTER SALPINGOSTOMY SO INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS LA English DT Letter DE ECTOPIC PREGNANCY; SALPINGOSTOMY; SALPINGOTOMY; TUBOPERITONEAL FISTULA ID ECTOPIC PREGNANCY; CLOSURE C1 BROOKE ARMY MED CTR,DEPT OBSTET & GYNECOL,FT SAM HOUSTON,TX 78234. NR 4 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCI PUBL IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0020-7292 J9 INT J GYNECOL OBSTET JI Int. J. Gynecol. Obstet. PD JUN PY 1995 VL 49 IS 3 BP 339 EP 340 DI 10.1016/0020-7292(95)02401-W PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA RE883 UT WOS:A1995RE88300018 PM 9764879 ER PT J AU GRACE, FI AF GRACE, FI TI LONG-ROD PENETRATION INTO TARGETS OF FINITE THICKNESS AT NORMAL IMPACT SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article ID PROJECTILES AB In this paper, a theory for one-dimensional penetration of long-rods into targets of finite thickness (plates) is developed. The target is defined as a ''finite'' mass that resides within the bulk of the target so that an equation of motion for the target mass can be constructed. This, together with an equation of motion for the penetrator and erosion equations for the two masses, provides a penetration solution for the finite-thickness target problem. The axial extent of the target mass is simply the thickness of the plate. Results provide expected penetration rates into plate targets, as well as unpenetrated target thickness (plug or spall) and residual penetator length, mass, and velocity. Good agreement was found between the theory, hydrocode results and experimental data. Also, the formulation becomes hydrodynamic penetration in appropriate limits and therefore encompasses jet penetration of these targets as well. RP USA, RES LAB, ABERDEEN PROVING GROUND, MD 21005 USA. NR 15 TC 10 Z9 12 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X EI 1879-3509 J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD JUN PY 1995 VL 16 IS 3 BP 419 EP 433 DI 10.1016/0734-743X(95)99778-P PG 15 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA RF719 UT WOS:A1995RF71900005 ER PT J AU POTAPOV, AV HOPKINS, MA CAMPBELL, CS AF POTAPOV, AV HOPKINS, MA CAMPBELL, CS TI A 2-DIMENSIONAL DYNAMIC SIMULATION OF SOLID FRACTURE .1. DESCRIPTION OF THE MODEL SO INTERNATIONAL JOURNAL OF MODERN PHYSICS C-PHYSICS AND COMPUTERS LA English DT Article DE FRACTURE; FRAGMENTATION; COMPUTER SIMULATION AB This paper describes a two-dimensional computer simulation of solid fracture that allows the body and the fragments to be followed well beyond the point of simple crack formation. The model is based on discrete particle computer simulations used for studying granular flows. Here, macroscopic polygonal solid are constructed by ''gluing'' together small elements. Depending on the stress conditions the glued bonds between the elements can respond elastically, undergo plastic failure or break, allowing cracks to propagate across the macroscopic particle along the boundaries between their microscopic constituents. In essence, this process creates a simulated material upon which breakage occurs. Several element shapes have been studied. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP POTAPOV, AV (reprint author), UNIV SO CALIF,DEPT MECH ENGN,LOS ANGELES,CA 90089, USA. RI Campbell, Charles/C-3653-2008 NR 18 TC 35 Z9 36 U1 0 U2 4 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA JOURNAL DEPT PO BOX 128 FARRER ROAD, SINGAPORE 9128, SINGAPORE SN 0129-1831 J9 INT J MOD PHYS C JI Int. J. Mod. Phys. C-Phys. Comput. PD JUN PY 1995 VL 6 IS 3 BP 371 EP 398 DI 10.1142/S0129183195000277 PG 28 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA RK008 UT WOS:A1995RK00800005 ER PT J AU POTAPOV, AV CAMPBELL, CS HOPKINS, MA AF POTAPOV, AV CAMPBELL, CS HOPKINS, MA TI A 2-DIMENSIONAL DYNAMIC SIMULATION OF SOLID FRACTURE .2. EXAMPLES SO INTERNATIONAL JOURNAL OF MODERN PHYSICS C-PHYSICS AND COMPUTERS LA English DT Article DE FRACTURE; FRAGMENTATION; COMPUTER SIMULATION AB This paper uses the model described in Ref. 1 to simulate fracture in many simple systems with the goal of evaluating the advantages and deficiencies of the model. The examples include compressive failure of a rectangular sample, four-point shear failure of a beam and the impact of particles with a plate and binary impacts of particles. Where possible, the simulated results seem to be in good agreement with typical experimental results. Finally, a simulation of ball-milling, which involves the flow and fracture of many particles is shown to demonstrate the overall utility of the model. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP POTAPOV, AV (reprint author), UNIV SO CALIF,DEPT MECH ENGN,LOS ANGELES,CA 90089, USA. RI Campbell, Charles/C-3653-2008 NR 10 TC 28 Z9 29 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA JOURNAL DEPT PO BOX 128 FARRER ROAD, SINGAPORE 9128, SINGAPORE SN 0129-1831 J9 INT J MOD PHYS C JI Int. J. Mod. Phys. C-Phys. Comput. PD JUN PY 1995 VL 6 IS 3 BP 399 EP 425 DI 10.1142/S0129183195000289 PG 27 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA RK008 UT WOS:A1995RK00800006 ER PT J AU TILELLI, JH AF TILELLI, JH TI TRANSFORMING THE MILITARY SO ISSUES IN SCIENCE AND TECHNOLOGY LA English DT Letter RP TILELLI, JH (reprint author), USA,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0748-5492 J9 ISSUES SCI TECHNOL JI Issues Sci. Technol. PD SUM PY 1995 VL 11 IS 4 BP 16 EP 17 PG 2 WC Engineering, Multidisciplinary; Engineering, Industrial; Multidisciplinary Sciences; Social Issues SC Engineering; Science & Technology - Other Topics; Social Issues GA RL781 UT WOS:A1995RL78100011 ER PT J AU ELSMORE, TF MCBRIDE, SA AF ELSMORE, TF MCBRIDE, SA TI AN 8-ALTERNATIVE CONCURRENT SCHEDULE - FORAGING IN A RADIAL MAZE SO JOURNAL OF APPLIED BEHAVIOR ANALYSIS LA English DT Meeting Abstract DE CONCURRENT SCHEDULES; MATCHING; FORAGING; INTERVAL REINFORCEMENT SCHEDULES; CHANGEOVER DELAY TIMING; MAZE; NOSE POKE; RATS C1 AMERICAN UNIV,WASHINGTON,DC 20016. RP ELSMORE, TF (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOURNAL APPL BEHAV ANAL PI LAWRENCE PA DEPT HUMAN DEVELOPMENT, UNIV KANSAS, LAWRENCE, KS 66045 SN 0021-8855 J9 J APPL BEHAV ANAL JI J. Appl. Behav. Anal. PD SUM PY 1995 VL 28 IS 2 BP 236 EP 236 PG 1 WC Psychology, Clinical SC Psychology GA RE403 UT WOS:A1995RE40300016 ER PT J AU BERG, BT AF BERG, BT TI BENDING OF SUPERELASTIC WIRES .1. EXPERIMENTAL ASPECTS SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Article AB A pure-bending apparatus is used to measure the constitutive relationship between applied pure bending moments and the resulting curvatures of a few superelastic alloy wires. The sample nickel-titanium alloy (NiTi) wires change phase when ample bending moments are imposed. Like the material's uniaxial tension stress-strain relationship, the measured moment-curvature relationship shows plateaus of constant moment and hysteresis. The bent shape is circular, except in the mixed phase region where it is composed of a phase mixture of circles. An example of the applications of the measured moment-curvature relations is presented in Part II of this paper where the three-point bending problem is considered. C1 UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. NR 5 TC 24 Z9 24 U1 0 U2 2 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0021-8936 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD JUN PY 1995 VL 62 IS 2 BP 459 EP 465 DI 10.1115/1.2895952 PG 7 WC Mechanics SC Mechanics GA RL944 UT WOS:A1995RL94400025 ER PT J AU BERG, BT AF BERG, BT TI BENDING OF SUPERELASTIC WIRES .2. APPLICATION TO 3-POINT BENDING SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Article AB The constitutive relationship between applied pure bending moment and the resulting curvature of a few superelastic alloy wires is applied to the three-point bending problem. Three-point bending experiments on hard rand soft loading machines are described The relationship between the applied deflection and the resulting force in three-point bending is calculated from a nonlinear Euler-Bernoulli Pad theory. A numerical procedure used to solve the three-point bending problem for both loading and unloading is briefly described and numerical results are compared with experiment. C1 UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. NR 4 TC 12 Z9 12 U1 0 U2 0 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0021-8936 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD JUN PY 1995 VL 62 IS 2 BP 466 EP 470 DI 10.1115/1.2895953 PG 5 WC Mechanics SC Mechanics GA RL944 UT WOS:A1995RL94400026 ER PT J AU WILCZAK, JM STRAUCH, RG RALPH, FM WEBER, BL MERRITT, DA JORDAN, JR WOLFE, DE LEWIS, LK WUERTZ, DB GAYNOR, JE MCLAUGHLIN, SA ROGERS, RR RIDDLE, AC DYE, TS AF WILCZAK, JM STRAUCH, RG RALPH, FM WEBER, BL MERRITT, DA JORDAN, JR WOLFE, DE LEWIS, LK WUERTZ, DB GAYNOR, JE MCLAUGHLIN, SA ROGERS, RR RIDDLE, AC DYE, TS TI CONTAMINATION OF WIND PROFILER DATA BY MIGRATING BIRDS - CHARACTERISTICS OF CORRUPTED DATA AND POTENTIAL SOLUTIONS SO JOURNAL OF ATMOSPHERIC AND OCEANIC TECHNOLOGY LA English DT Article ID RADAR AB Winds measured with 915- and 404-MHz wind profilers are frequently found to have nonrandom errors as large as 15 m s(-1) when compared to simultaneously measured rawinsonde winds. Detailed studies of these errors, which occur only at night below about 4 km in altitude and have a pronounced seasonal pattern, indicate that they are due to the wind profilers' detection of migrating songbirds (passerines). Characteristics of contaminated data at various stages of data processing are described, including raw time series, individual spectra, averaged spectra, 30- or 60-s moments, 3- or 6-min winds, and hourly averaged winds. An automated technique for the rejection of contaminated data in historical datasets, based on thresholding high values of moment-level reflectivity and spectral width, is shown to be effective. Techniques designed for future wind profiler data acquisition systems are described that show promise for rejecting bird echoes, with the additional capability of being able to retrieve the true wind velocity in many instances. Finally, characteristics of bird migration revealed by wind profilers are described, including statistics of the spring (March-May) 1993 migration season determined from the 404-MHz Wind Profiler Demonstration Network (WPDN). During that time, contamination of moment data occurred on 43% of the nights monitored. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM. MCGILL UNIV,DEPT ATMOSPHER & OCEAN SCI,MONTREAL,PQ,CANADA. UNIV COLORADO,CIRES,BOULDER,CO. SONOMA TECHNOL INC,SANTA ROSA,CA. RP WILCZAK, JM (reprint author), NOAA,ERL,ENVIRONM TECHNOL LAB,BOULDER,CO 80303, USA. NR 28 TC 89 Z9 90 U1 1 U2 6 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0739-0572 J9 J ATMOS OCEAN TECH JI J. Atmos. Ocean. Technol. PD JUN PY 1995 VL 12 IS 3 BP 449 EP 467 DI 10.1175/1520-0426(1995)012<0449:COWPDB>2.0.CO;2 PG 19 WC Engineering, Ocean; Meteorology & Atmospheric Sciences SC Engineering; Meteorology & Atmospheric Sciences GA RD279 UT WOS:A1995RD27900001 ER PT J AU NAUSS, JL REID, RH SADEGHNASSERI, S AF NAUSS, JL REID, RH SADEGHNASSERI, S TI ACCURACY OF A STRUCTURAL HOMOLOGY MODEL FOR A CLASS-II HISTOCOMPATIBILITY PROTEIN, HLA-DR1 - COMPARISON TO THE CRYSTAL-STRUCTURE SO JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS LA English DT Article ID T-CELL EPITOPE; PEPTIDE ANTIGENS; 3-DIMENSIONAL STRUCTURE; MHC; BINDING; MOLECULES; RECOGNITION; COMPLEX; POLYMORPHISM; HLA-B27 AB Structural homology modeling is used to test the accuracy by which a Class I major histocompatibility complex (MHC) could be used to model a Class II MHC. The crystal structure of HLA-aw68 served as a reference molecule to model HLA-DR1. The resulting model was compared to the recently released crystal structure by Brown et al. (Nature, Vol. 364, p. 33-39 (1993)). The overall tertiary structure motif(two alpha-helices and a beta-sheet forming a peptide binding cleft) was maintained. However, significant deviations in the secondary structure elements were found between the model and the DR1 crystal structure. These deviations were consistent with the differences between Class I and Class II crystal structures. In regions where the model and DR1 crystal structures are most similar, side chain orientations are also similar. Specific peptide-MHC interactions are discussed and compared with the crystal structure results. C1 WALTER REED ARMY INST RES,DEPT GASTROENTEROL,DIV MED,WASHINGTON,DC 20307. ORAVAX INC,CAMBRIDGE,ENGLAND. NIAID,LI,BETHESDA,MD 20892. OI Sadegh-Nasseri, Scheherazade/0000-0002-8127-1720 NR 32 TC 4 Z9 4 U1 0 U2 1 PU ADENINE PRESS INC PI GUILDERLAND PA PO BOX 355/340, GUILDERLAND, NY 12084 SN 0739-1102 J9 J BIOMOL STRUCT DYN JI J. Biomol. Struct. Dyn. PD JUN PY 1995 VL 12 IS 6 BP 1213 EP 1233 PG 21 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA RF744 UT WOS:A1995RF74400005 PM 7669268 ER PT J AU XENOS, JS HOPKINSON, WJ MULLIGAN, ME OLSON, EJ POPOVIC, NA AF XENOS, JS HOPKINSON, WJ MULLIGAN, ME OLSON, EJ POPOVIC, NA TI THE TIBIOFIBULAR SYNDESMOSIS - EVALUATION OF THE LIGAMENTOUS STRUCTURE, METHODS OF FIXATION, AND RADIOGRAPHIC ASSESSMENT SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID TIBIO-FIBULAR SYNDESMOSIS; INTERNAL-FIXATION; ANKLE; MECHANISM; FRACTURES; INJURY; SCREW AB Twenty-five fresh-frozen cadaveric specimens were used to evaluate the role of the syndesmotic ligaments when the ankle is loaded with external rotation torque. An apparatus was constructed that allowed pure external-rotation torque to be applied through the ankle with the foot in neutral flexion. The apparatus provided solid fixation of the tibia while allowing free movement of the fibula in all planes. The syndesmotic ligaments were incrementally sectioned, and direct measurements of anatomical diastasis were made. Mortise and lateral radiographs were made at each increment under both loaded (5.0 newton-meters) and unloaded conditions. After all structures of the syndesmosis had been divided, the syndesmosis was reduced and was repaired with one or two screws. The strength of the repair was measured with incremental increases in torque of 1.0 newton-meter. The radiographs were measured by three independent observers in a blind fashion. In order to evaluate intraobserver error, each observer was randomly given forty radiographs to reinterpret. Diastasis and rotation were found to be related to the amount of injury of the ligament (p < 0.0001). After the entire syndesmosis had been divided, application of a 5.0-newton-meter torque resulted in a mean diastasis of 7.3 millimeters. The subsequent repair of the anterior tibiofibular ligament with suture failed at a mean of 2.0 newton-meters (range, 1.0 to 6.0 newton-meters) of torque. Repair with two screws was found to be stronger than repair with one, with the first construct failing at a mean of 11.0 newton-meters (range, 5.0 to 15.0 newton-meters) and the second, at a mean of 6.2 newton-meters (range, 2.0 to 10.0 newton-meters) (p = 0.0005). Failure of the screw fixation was not associated with the maximum previous diastasis (p = 0.13). Measurements of anatomical diastasis were compared with measurements made on the mortise and lateral radiographs. Measurements on the stress mortise radiographs had a weak correlation with diastasis (r = 0.41, p < 0.0001). However, measurements on the stress lateral radiographs had a higher correlation (r = 0.81, p < 0.0001). Additionally, interobserver correlation was significantly higher for the measurements on the lateral radiographs (r = 0.87, p < 0.0001) than for those on the mortise radiographs (r = 0.56, p < 0.0001). Intraobserver correlation for the three observers was poor with regard to the measurements on the mortise radiographs (r = 0.12, 0.42, and 0.25). The respective correlations for the measurements on the lateral radiographs were r = 0.81, 0.90, and 0.89. CLINICAL RELEVANCE: Diastasis of the distal aspects of the tibia and fibula on application of external rotation torque is related to the degree of injury to the syndesmosis. Also, the mechanical strength of fixation with two screws is superior to that of fixation with one screw and to that of suture repair of the anterior tibiofibular ligament. Assessment of the disruption of the syndesmosis on stress lateral radiographs has a much higher correlation with anatomical diastasis than does that on stress mortise radiographs. Furthermore, the stress lateral radiograph appears to be more reliable for the assessment of the syndesmosis. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,DIAGNOST RADIOL SERV,WASHINGTON,DC 20307. RP XENOS, JS (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,ORTHOPAED SURG SERV,WASHINGTON,DC 20307, USA. NR 45 TC 149 Z9 160 U1 1 U2 12 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. vol. PD JUN PY 1995 VL 77A IS 6 BP 847 EP 856 PG 10 WC Orthopedics; Surgery SC Orthopedics; Surgery GA RF518 UT WOS:A1995RF51800005 PM 7782357 ER PT J AU OWENS, PM AF OWENS, PM TI A GENERAL-CHEMISTRY COURSE THAT FOCUSES ON THE EMERGING CHEMICAL SCIENCES SO JOURNAL OF CHEMICAL EDUCATION LA English DT Editorial Material RP OWENS, PM (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0021-9584 J9 J CHEM EDUC JI J. Chem. Educ. PD JUN PY 1995 VL 72 IS 6 BP 528 EP 530 PG 3 WC Chemistry, Multidisciplinary; Education, Scientific Disciplines SC Chemistry; Education & Educational Research GA RG158 UT WOS:A1995RG15800019 ER PT J AU DUBOIS, A FIALA, N WEICHBROD, RH WARD, GS NIX, M MEHLMAN, PT TAUB, DM PEREZPEREZ, GI BLASER, MJ AF DUBOIS, A FIALA, N WEICHBROD, RH WARD, GS NIX, M MEHLMAN, PT TAUB, DM PEREZPEREZ, GI BLASER, MJ TI SEROEPIZOOTIOLOGY OF HELICOBACTER-PYLORI GASTRIC INFECTION IN NONHUMAN-PRIMATES HOUSED IN SOCIAL ENVIRONMENTS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID CAMPYLOBACTER-PYLORI; MACACA-NEMESTRINA; SP-NOV; STOMACH; RISK; SEROPREVALENCE; EPIDEMIOLOGY; BACTERIUM; CARCINOMA; ANTIBODY AB We determined the seroepizootiology of Helicobacter pylori infection in rhesus monkeys. Plasma was obtained from 196 animals (age range, 1 to 22 years) that were housed in social environments, either in indoor gang cages, in outdoor corrals, or in free-ranging forested conditions. Plasma immunoglobulin G levels were determined with a specific enzyme-linked immunosorbent assay, and the cutoff immunoglobulin G value for H. pylori seropositivity was determined from a study of 25 monkeys whose infection status was assessed by light microscopy and culture. One-year-old animals of both genders in all housing conditions had the lowest rate of positivity (60% in monkeys 1 year old versus 81% in monkeys 2 to 10 years old, P = 0.026). In addition, females tended to have higher rates of positivity than males. Seroconversion during a 1-year observation period occurred in 7 (28%) of 25 seronegative animals, Seroreversion occurred in 3 (4%) of the 78 positive animals; all 3 of these animals had received antimicrobial agents during the year, These observations demonstrate that the epizootiology of H. pylori infection in rhesus monkeys may serve as a model for human infection. C1 USA, RADIOBIOL RES INST, DEPT PHYSIOL, BETHESDA, MD USA. USA, RADIOBIOL RES INST, DEPT VET MED, BETHESDA, MD USA. LAB ANIM BREEDERS & SERV INC, YEMASSEE, SC, BRAZIL. VANDERBILT UNIV, SCH MED, DEPT MED, DIV INFECT DIS, NASHVILLE, TN 37212 USA. DEPT VET AFFAIRS MED CTR, NASHVILLE, TN 37212 USA. RP DUBOIS, A (reprint author), UNIFORMED SERV UNIV HLTH SCI, DEPT MED, DIV DIGEST DIS, GASTROINTESTINAL & LIVER STUDIES LAB, BETHESDA, MD 20814 USA. FU NCI NIH HHS [R0ICA 58834] NR 35 TC 29 Z9 30 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUN PY 1995 VL 33 IS 6 BP 1492 EP 1495 PG 4 WC Microbiology SC Microbiology GA QZ723 UT WOS:A1995QZ72300012 PM 7650173 ER PT J AU THOMPSON, EF HADLEY, LL AF THOMPSON, EF HADLEY, LL TI NUMERICAL MODELING OF HARBOR RESPONSE TO WAVES SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE COASTAL ENGINEERING; HARBOR HYDRODYNAMICS; HARBOR OSCILLATIONS; LONG WAVES; SHORT WAVES; COMPUTER PROGRAMS AB Both short (up to 25-sec period) and long (2S-sec to 10-min period) waves can cause damaging conditions in harbors. Harbors of all sizes are affected, ranging from small recreational harbors to large commercial harbors. The U.S. Army Corps of Engineers has many years of experience with harbor wave concerns and has developed powerful and complementary numerical and physical modeling tools. The CE numerical model described in this paper, can be used effectively to answer many engineering questions about harbor wave response. Two examples are presented of numerical model studies to evaluate the relative level of short wave protection provided by different breakwater configurations. Two additional examples illustrate model applications to evaluate long wave-induced harbor oscillations. RP THOMPSON, EF (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 22 TC 5 Z9 5 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SUM PY 1995 VL 11 IS 3 BP 744 EP 753 PG 10 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA RN670 UT WOS:A1995RN67000017 ER PT J AU POLLOCK, CB AF POLLOCK, CB TI HELICOPTER-BORNE NEARSHORE SURVEY SYSTEM, A VALUABLE TOOL IN DIFFICULT SURVEY AREAS SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE BATHYMETRY; PROFILING; TOTAL DISTANCE STATION; HELICOPTER SURVEY AB Because the U.S. West Coast can present hazardous conditions in which to conduct held monitoring (USAGE) Portland District has developed a bathymetry collection system which can operate in high energy wave conditions or dangerous environments inaccessible to other types of survey methods. The new system is capable of traversing steep grades, passing safely through the surf zone, operating on land, over structures, or in water with remarkable accuracy. A marked lead line suspended from a helicopter is used as a survey rod. A survey crew on shore uses a total station and a level to measure and location of the helicopter and the depth of the seabed. The USAGE Portland District has been using this system since 1960. In the summer of 1990, this Helicopter-Borne Nearshore survey System (HBNSS) was compared for accuracy and repeatability to the USAGE Coastal Research Amphibious Buggy (CRAB) at the USAGE Waterways Experiment Station, Coastal Engineering Research Center (CERC) Field Research Facility in Duck, North Carolina. RP POLLOCK, CB (reprint author), USA,CORPS ENGINEERS,COASTAL ENGN RES CTR,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 5 TC 1 Z9 1 U1 0 U2 1 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SUM PY 1995 VL 11 IS 3 BP 959 EP 966 PG 8 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA RN670 UT WOS:A1995RN67000035 ER PT J AU OLSON, MA SCOVILL, JP HACK, DC AF OLSON, MA SCOVILL, JP HACK, DC TI SIMULATION ANALYSIS OF FORMYCIN 5'-MONOPHOSPHATE ANALOG SUBSTRATES IN THE RICIN A-CHAIN ACTIVE-SITE SO JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN LA English DT Article DE RICIN; N-GLYCOSIDASE; ENZYME-LIGAND COMPLEX; MOLECULAR DYNAMICS; STRUCTURAL INTERACTIONS; BINDING FREE ENERGIES ID N-GLYCOSIDASE ACTIVITY; AMINO-ACID-SEQUENCE; EUKARYOTIC RIBOSOMES; ESCHERICHIA-COLI; AMP NUCLEOSIDASE; DIRECTED MUTAGENESIS; NUCLEOTIDE-SEQUENCE; ANTIVIRAL PROTEIN; TOXIC LECTINS; RNA AB Ricin is an RNA N-glycosidase that hydrolyzes a single adenine base from a conserved loop of 28S ribosomal RNA, thus inactivating protein synthesis. Molecular-dynamics simulation methods ae used to analyze the structural interactions and thermodynamics that govern the binding of formycin 5'-monophosphate (FMP) and several of its analogs to the active site of ricin A-chain. Simulations are carried out initiated form the X-ray crystal structure of the ricin-FMP complex with the ligand modeled as a dianion, monoanion and zwitterion. Relative changes in binding free energies are estimated for FMP analogs constructed from amino substitutions at the 2- and 2'-positions, and from hydroxyl substitution at the 2'-position. RP OLSON, MA (reprint author), USA,MED RES INST INFECT DIS,DEPT BIOCHEM & CELL BIOL,FREDERICK,MD 21702, USA. NR 38 TC 5 Z9 5 U1 0 U2 0 PU ESCOM SCI PUBL BV PI LEIDEN PA PO BOX 214, 2300 AE LEIDEN, NETHERLANDS SN 0920-654X J9 J COMPUT AID MOL DES JI J. Comput.-Aided Mol. Des. PD JUN PY 1995 VL 9 IS 3 BP 226 EP 236 DI 10.1007/BF00124454 PG 11 WC Biochemistry & Molecular Biology; Biophysics; Computer Science, Interdisciplinary Applications SC Biochemistry & Molecular Biology; Biophysics; Computer Science GA RG927 UT WOS:A1995RG92700003 PM 7561975 ER PT J AU TOBER, RL BAHDER, TB BRUNO, JD AF TOBER, RL BAHDER, TB BRUNO, JD TI CHARACTERIZING ELECTRIC-FIELDS IN (111)B INGAAS QUANTUM-WELLS USING ELECTRIC-FIELD MODULATED PHOTOLUMINESCENCE AND REFLECTANCE TECHNIQUES SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE ELECTROREFLECTANCE; PHOTOREFLECTANCE; PIEZOELECTRIC; STRAINED LAYER QUANTUM WELLS ID SUPERLATTICES AB We have performed a series of electroreflectance, photoluminescence, and electric-field-modulated photoluminescence experiments to characterize the strain-induced electric fields in(111)B InGaAs/AlGaAs quantum well p-i-n diode structures. A 180 degrees phase change in the Lineshapes of electroreflectance spectra of these samples determines when the quantum well is biased to flatband. Using this bias and a depletion model for the diode, the polarization field in the quantum well can be determined. Contrary to expectations, this polarization field increases significantly with increasing temperature. In addition, at fixed temperature, the quantum well transition energies red-shift with increasing excitation intensity when excited by photons of energy higher than the lowest quantum well transition but lower than the AlGaAs diode's bandgap. When excited with photons of energy greater than the AlGaAs bandgap, the transition energy first red shifts then blue shifts with increasing excitation intensity. RP TOBER, RL (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 9 TC 2 Z9 2 U1 0 U2 1 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUN PY 1995 VL 24 IS 6 BP 793 EP 798 DI 10.1007/BF02659742 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA RC210 UT WOS:A1995RC21000014 ER PT J AU RENFER, L THOMPSON, IM DESMOND, PM ZEIDMAN, EJ MUELLER, EJ AF RENFER, L THOMPSON, IM DESMOND, PM ZEIDMAN, EJ MUELLER, EJ TI BALLOON DILATION OF THE PROSTATE - CORRELATION WITH MAGNETIC-RESONANCE-IMAGING AND TRANSRECTAL ULTRASOUND FINDINGS SO JOURNAL OF ENDOUROLOGY LA English DT Article ID HYPERPLASIA; DILATATION AB Alternative treatments for benign prostatic hyperplasia are under intense scrutiny. Initial reports on balloon dilation therapy showed success rates of 60% to 90%, although follow-up was brief. We present a prospective non-blinded study assessing the efficacy of an investigational balloon dilatation catheter (105 Fr at 3 atm) as well as the MRI findings preoperatively and postoperatively. Twenty-seven men underwent balloon dilation and have been followed for at least 1 year. Twelve patients (44%) ultimately required definitive transurethral prostatectomy during follow-up. A mild improvement was noted in the symptom score and flow rate in the responder group. Fracture of the anterior commissure was accomplished in only 5 patients (18%) despite diligent efforts. The MRI scans showed no change in the prostate in any patients. Intraoperative transrectal ultrasound scanning suggested that proximal balloon migration can occur. Our experience with this balloon system leads us to recommend that it remain an investigational procedure. RP RENFER, L (reprint author), BROOKE ARMY MED CTR,DEPT SURG,UROL SURG SERV,FT SAM HOUSTON,TX 78234, USA. RI Desmond, Patricia /D-1966-2014 OI Desmond, Patricia /0000-0002-4803-6323 NR 8 TC 1 Z9 1 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0892-7790 J9 J ENDOUROL JI J. Endourol. PD JUN PY 1995 VL 9 IS 3 BP 283 EP 286 DI 10.1089/end.1995.9.283 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA RH223 UT WOS:A1995RH22300016 PM 7550276 ER PT J AU ROBINS, GW BLOUNT, BW ARLINE, A AF ROBINS, GW BLOUNT, BW ARLINE, A TI EFFECT OF TERBUTALINE TOCOLYSIS ON INFANT BIRTH-WEIGHT SO JOURNAL OF FAMILY PRACTICE LA English DT Article DE TOCOLYSIS; TERBUTALINE; BIRTH-WEIGHT; PREGNANCY ID MATERNAL GLUCOSE-INTOLERANCE; ORAL TERBUTALINE; GESTATIONAL-AGE; PRETERM LABOR; THERAPY; TOLERANCE; PREGNANCY; BIRTH AB Background. Previous research has suggested that terbutaline sulfate increases serum glucose in pregnant women. Increases in serum glucose in women who have gestational diabetes mellitus often lead to the birth of larger infants. This study examines the effect on infant birthweight of terbutaline used as a tocolytic agent in otherwise normal term pregnancies. Methods. An historical cohort study was conducted of all births in a 12-month period at a US Army community hospital. There were 1376 deliveries of all types; 481 of the patients were excluded for variables that influence gestational duration or fetal weight, and 5 patients' records were lost. Birthweights relative to gestational age were compared. Results. The two groups (women who were treated with terbutaline, n=94; control group, n=796) differed with respect to age (terbutaline group, 1.6 years younger, P=.002); pregravid weight (terbutaline group, 10.3 lb lighter, P<.001); and total weight gain (terbutaline group, 3.2 lb less, P=.001). The groups were comparable in all other variables studied (P>.05). Women receiving terbutaline therapy (average length of therapy, 4.7 weeks) gave birth an average of 1 week earlier than those not treated with terbutaline (39.09 weeks and 40.09 weeks, respectively, P<.001). The mean absolute birthweight of infants exposed to terbutaline in utero was less than that of infants from the control group (P<.001), but this difference (191.6 g) can be accounted for by the difference in average gestational age between the terbutaline group and the control group. There was no difference in birthweight (P>.05) when birthweight relative to gestational age was compared between the two groups. Conclusions. Women in this study who were treated with terbutaline did not give birth to larger infants. The previously noted hyperglycemia in women receiving terbutaline may not have been present in this study population or may not have been significant enough to affect birthweight. C1 MADIGAN ARMY MED CTR,TACOMA,WA 98431. EMORY UNIV,SCH MED,ATLANTA,GA 30322. RP ROBINS, GW (reprint author), EISENHOWER ARMY MED CTR,DEPT FAMILY & COMMUNITY MED,FT GORDON,GA 30905, USA. NR 23 TC 0 Z9 0 U1 0 U2 0 PU APPLETON & LANGE PI E NORWALK PA 25 VAN ZANT ST, E NORWALK, CT 06855 SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD JUN PY 1995 VL 40 IS 6 BP 581 EP 585 PG 5 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA RC213 UT WOS:A1995RC21300020 PM 7775912 ER PT J AU FLINT, NA MADSEN, JD AF FLINT, NA MADSEN, JD TI THE EFFECT OF TEMPERATURE AND DAYLENGTH ON THE GERMINATION OF POTAMOGETON NODOSUS TUBERS SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article AB The effects of temperature and daylength were studied in the germination of American pondweed (Potamogeton nodosus Poir.) tubers. Germination was examined at temperatures ranging from 5 to 30 degrees C in conjunction with light treatments of short and long daylength and continuous darkness. Greatest percentage of tuber germination occurred between 15 and 20 degrees C. Within this temperature range, daylength did not significantly affect germination. Outside this temperature range, however, the absence of light inhibited germination. From these results, we conclude that temperature was the most important factor controlling germination, with an optimal range of 15 to 20 degrees C. Daylength (14:10 versus 10:14) had no effect on germination, but the absence of light suppressed germination at 10, 25, and 30 degrees C. The results were further supported by similar data obtained from a pond study of P. nodosus. C1 USA,ENGINEER WATERWAYS EXPT STN,LEWISVILLE AQUAT ECOSYST RES FACIL,LEWISVILLE,TX 75056. NR 7 TC 6 Z9 6 U1 0 U2 3 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD JUN PY 1995 VL 10 IS 2 BP 125 EP 128 DI 10.1080/02705060.1995.9663426 PG 4 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA RF353 UT WOS:A1995RF35300004 ER PT J AU RATTO, S SITZ, KV SCHERER, AM MANCA, F LOOMIS, LD COX, JH REDFIELD, RR BIRX, DL AF RATTO, S SITZ, KV SCHERER, AM MANCA, F LOOMIS, LD COX, JH REDFIELD, RR BIRX, DL TI ESTABLISHMENT AND CHARACTERIZATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) ENVELOPE-SPECIFIC CD4(+) T-LYMPHOCYTE LINES FROM HIV-1-SEROPOSITIVE PATIENTS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID GP160 SUBUNIT VACCINE; SEROPOSITIVE INDIVIDUALS; SYNTHETIC PEPTIDES; IMMUNE-RESPONSE; CELL EPITOPES; HELPER CELLS; CD4+; RECOGNITION; INFECTION; IDENTIFICATION AB Human immunodeficiency virus type 1 (HIV-1) gp160-, gp120-, and tetanus toxoid-specific CD4(+) T lymphocyte lines were developed from 11 HIV-1-seropositive volunteers enrolled in a vaccine therapy trial. Of the 20 HIV-1 envelope-specific T cell lines, 9 were challenged with a panel of overlapping peptides spanning the gp 120LAI sequence. The most frequently recognized regions were amino acids 74-105 in the C1 region and 306-328 in the V3 region. When tested against a panel of divergent HIV-1 envelopes, 55% of the envelope-specific lines were able to recognize gp120MN, while only 22% recognized gp120SF2. Cytotoxicity testing with HIV-1 envelope antigen or peptides demonstrated killing by all 3 envelope-specific lines tested. Supernatants from 2 of 9 lines had high titers of p24 gag antigen, which did not seem to interfere with functional properties. C1 SRA TECHNOL INC,ROCKVILLE,MD. UNIV GENOA,DEPT IMMUNOL,GENOA,ITALY. WALTER REED ARMY INST RES,INFECT DIS SERV,ROCKVILLE,MD. RP RATTO, S (reprint author), WALTER REED ARMY INST RES,HENRY M JACKSON FDN,DIV RETROVIROL,13 TAFT CT,STE 200,ROCKVILLE,MD 20850, USA. NR 35 TC 25 Z9 25 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUN PY 1995 VL 171 IS 6 BP 1420 EP 1430 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RB298 UT WOS:A1995RB29800005 PM 7769275 ER PT J AU GORDON, DM MCGOVERN, TW KRZYCH, U COHEN, JC SCHNEIDER, I LACHANCE, R HEPPNER, DG YUAN, G HOLLINGDALE, M SLAOUI, M HAUSER, P VOET, P SADOFF, JC BALLOU, WR AF GORDON, DM MCGOVERN, TW KRZYCH, U COHEN, JC SCHNEIDER, I LACHANCE, R HEPPNER, DG YUAN, G HOLLINGDALE, M SLAOUI, M HAUSER, P VOET, P SADOFF, JC BALLOU, WR TI SAFETY, IMMUNOGENICITY, AND EFFICACY OF A RECOMBINANTLY PRODUCED PLASMODIUM-FALCIPARUM CIRCUMSPOROZOITE-PROTEIN HEPATITIS-B SURFACE-ANTIGEN SUBUNIT VACCINE SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID MALARIA VACCINE; RESPONSES; EPITOPE; SPOROZOITES; RECOGNITION; VOLUNTEERS; ANTIBODIES; REGIONS; DOMAINS; HUMANS AB Twenty malaria-naive volunteers received a recombinant Plasmodium falciparum malaria vaccine (RTS,S) containing 19 NANP repeats and the carboxy terminus (amino acids 210-398) of the circumsporozoite (CS) antigen coexpressed in yeast with hepatitis B surface antigen, Ten received vaccine adjuvanted with alum, and 10 received vaccine adjuvanted with alum plus 3-deacylated monophosphoryl lipid A (MPL). Both formulations were well tolerated and immunogenic. MPL enhanced CS antibody levels (measured by ELISA, immunofluorescence, and inhibition of sporozoite invasion assays). After sporozoite challenge, 6 of 6 in the alum group and 6 of 8 in the alum-MPL group developed patent malaria. Protected subjects had higher levels of C'S antibody titers on day of challenge than did nonprotected subjects. After immunization, 1 protected subject had increased cytotoxic T lymphocyte activity against CS and recall of memory T cell responses to RTS,S and selected CS. C1 WALTER REED ARMY INST RES, DEPT IMMUNOL, WASHINGTON, DC USA. USA, MED RES INST INFECT DIS, FT DETRICK, MD 21702 USA. SMITHKLINE BEECHAM BIOL, RIXENSART, BELGIUM. BIOMED RES INST, ROCKVILLE, MD 20852 USA. NR 24 TC 157 Z9 164 U1 2 U2 8 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JUN PY 1995 VL 171 IS 6 BP 1576 EP 1585 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RB298 UT WOS:A1995RB29800026 PM 7769295 ER PT J AU HENDRIX, CW AF HENDRIX, CW TI CONSIDERATION OF THE PREVALENCE OF CYTOMEGALOVIRUS RETINITIS SIGNIFICANTLY ALTERS THE ASSESSMENT OF A SERUM CYTOMEGALOVIRUS DNA TEST SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; DIAGNOSIS C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. RP HENDRIX, CW (reprint author), JOHNS HOPKINS UNIV,SCH MED,DIV CLIN PHARMACOL,600 N WOLFE ST,OSLER 527,BALTIMORE,MD 21287, USA. RI Hendrix, Craig/G-4182-2014 OI Hendrix, Craig/0000-0002-5696-8665 NR 9 TC 1 Z9 1 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUN PY 1995 VL 171 IS 6 BP 1688 EP 1689 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA RB298 UT WOS:A1995RB29800053 PM 7769320 ER PT J AU MARSHALL, WJ AF MARSHALL, WJ TI UNDERSTANDING LASER HAZARD EVALUATION SO JOURNAL OF LASER APPLICATIONS LA English DT Article DE LASER HAZARDS; ANSI Z136.1 STANDARD; MAXIMUM PERMISSIBLE EXPOSURE; LASER CLASSIFICATION; LIMITING APERTURE; MEASUREMENT APERTURE; EXTENDED-SOURCE LASER; DIODE LASER AB The current 1993 version of the ANSI Z136.1 standard for the safe use of lasers provides maximum permissible exposures which more closely match available biological injury data. Interpreting the standard can be more difficult at times than with previous versions. By keeping the biological injury mechanism in mind, the reasoning behind the multitude of rules contained in the standard are more understandable. RP MARSHALL, WJ (reprint author), USA,CTR HLTH PROMOT & PREVENT MED PROVIS,ABERDEEN PROVING GROUND,MD 21010, USA. NR 5 TC 6 Z9 6 U1 0 U2 0 PU LASER INST AMER PI ORLANDO PA 12424 RESEARCH PARKWAY SUITE 125, ORLANDO, FL 32826 SN 1042-346X J9 J LASER APPL JI J. Laser Appl. PD JUN PY 1995 VL 7 IS 2 BP 99 EP 105 PG 7 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA RJ554 UT WOS:A1995RJ55400007 ER PT J AU SCHWARTZ, GN KESSLER, SW SZABO, JM BURRELL, LM FRANCIS, ML AF SCHWARTZ, GN KESSLER, SW SZABO, JM BURRELL, LM FRANCIS, ML TI NEGATIVE REGULATORS MAY MEDIATE SOME OF THE INHIBITORY EFFECTS OF HIV-1-INFECTED STROMAL CELL-LAYERS ON ERYTHROPOIESIS AND MYELOPOIESIS IN HUMAN BONE-MARROW LONG-TERM CULTURES SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE COLONY FORMING UNITS FOR GRANULOCYTES MACROPHAGES (CFU-GM); BURST FORMING UNITS ERYTHROID (BFU-E); BONE MARROW LONG-TERM CULTURES (LTC); HIV-1(ADA); INTERFERON-ALPHA (IFN-ALPHA); TUMOR NECROSIS FACTOR ALPHA (TNF-ALPHA); INTERLEUKIN-4 (IL-4); TRANSFORMING GROWTH FACTOR BETA (TGF-BETA) ID HUMAN-IMMUNODEFICIENCY-VIRUS; HEMATOPOIETIC PROGENITOR CELLS; RECOMBINANT INTERFERON-ALPHA; TUMOR-NECROSIS-FACTOR; HIV-1-INFECTED SUBJECTS; MONOCYTES MACROPHAGES; INVITRO GROWTH; REPLICATION; PROLIFERATION; INTERLEUKIN-4 AB This report presents results concerning the potential role of negative regulators in hematopoietic suppression observed in human immunodeficiency virus (HIV)-infected long-term cultures (LTC) of human bone marrow cells, Confluent stromal cell layers established from human bone marrow cells were exposed to HIV-1(ADA), a monocytotropic strain of HIV-1, A progressive increase in the concentration of HIV-1 p24 antigen in cultures exposed to HIV-1(ADA) demonstrated that there was a productive infection, Cells from both noninfected and HIV-infected stromal cell layers produced factors that stimulated the proliferation of colony-forming units for granulocytes and macrophages (CFU-GM) from noninfected CD34(+) cells, In contrast, when noninfected CD34(+) cells were directly cocultured on intact stromal cell layers fewer CFU-GM and burst-forming units for erythroid cells (CFU-GM) were detected in HN-infected LTC than in noninfected LTC, One week after the addition of CD34(+) cells, the number of CFU-GM in HIV-infected LTC in six of nine experiments was reduced compared to noninfected control LTC, In those six experiments, the number of CFU-GM was only 53 +/- 5% (SEM) of the number in noninfected LTC, The number of BFU-E in HIV-1-infected LTC was only 46 +/- 5% of the number in noninfected LTC (n = 5), There were fewer BFU-E in HIV-1-infected LTC, whether or not there was a reduced number of CFU-GM, Neutralizing antibody to tumor necrosis factor alpha (TNF-alpha) had no effect on the number of BFU-E in HIV-infected LTC, The number of BFU-E, however, was 2.1 +/- 0.2-fold greater (n = 3) in HIV-infected LTC incubated with neutralizing antibody to interferona-alpha. In HIV-infected LTC with decreased numbers of CFU-GM, the number of CFU-CM was approximately 2-fold greater after incubation of HIV-infected LTC with anti-interleukin-4 (IL-4), The effect of anti-TNF-alpha was variable, and anti-transforming growth factor-beta had no effect on the number of CFU GM in HIV-infected LTC, After 2 weeks, the number of CFU-GM in HN-infected LTC incubated with anti-IL-4 and anti-TNF-alpha was 2- to 4-fold greater than in untreated HIV-infected LTC, Antibody treatment did not promote an increase in the number of CFU CM in noninfected LTC or in LTC in which CFU-GM numbers were not reduced after HIV infection. These results demonstrate that some cells in the stromal cell layers of LTC were targets for HIV-1(ADA), and that HIV-infected stromal cell layers suppressed or delayed the production of both CFU-GM and BFU-E. These results also suggest that hematopoietic suppression in HIV-infected LTC may be mediated by growth-in-hibitory cytokines that are different for erythropoiesis and myelopoiesis. C1 USN,MED RES INST,IMMUNE CELL BIOL PROGRAM,BETHESDA,MD. WALTER REED ARMY MED CTR,DEPT HEMATOL ONCOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. RP SCHWARTZ, GN (reprint author), NCI,MED BRANCH,TRANPLANTAT THERAPY SECT,BLDG 10,RM 12N226,BETHESDA,MD 20892, USA. NR 53 TC 15 Z9 15 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD JUN PY 1995 VL 57 IS 6 BP 948 EP 955 PG 8 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA RE360 UT WOS:A1995RE36000021 PM 7540643 ER PT J AU FOX, GR TROLIERMCKINSTRY, S KRUPANIDHI, SB CASAS, LM AF FOX, GR TROLIERMCKINSTRY, S KRUPANIDHI, SB CASAS, LM TI PT/TI/SIO2/SI SUBSTRATES SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID TITANATE THIN-FILMS; SI; LAYERS AB Pt/Ti/SiO2/Si structures have been studied to investigate the structural, chemical, and microstructural changes that occur during annealing. Grain growth of the as-deposited Pt columns was observed after annealing at 650 degrees C, and extensive changes in the Pt microstructure were apparent following a 750 degrees C anneal for 20 min. In addition, two types of defects were identified on the surfaces of annealed substrates. Defect formation was retarded when the surface was covered with a ferroelectric film. Concurrent with the annealing-induced Pt microstructure changes, Ti from the adhesion layer between the Pt and the SiO2 migrated into the Pt layer and oxidized. It was shown with spectroscopic ellipsometry and Auger electron spectroscopy that for long annealing times, the titanium oxide layer can reach the Pt surface. Consequently, at the processing temperatures utilized in preparing many ferroelectric thin films, the substrate is not completely inert or immobile. The changes associated with Ti migration could be especially problematic in techniques that require the substrate to be heated prior to film deposition. C1 PENN STATE UNIV,MAT RES LAB,UNIVERSITY PK,PA 16802. USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,AMSRL EP EC M,FT MONMOUTH,NJ 07703. NR 22 TC 65 Z9 65 U1 2 U2 16 PU MATERIALS RESEARCH SOCIETY PI PITTSBURGH PA 9800 MC KNIGHT ROAD SUITE 327, PITTSBURGH, PA 15237 SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD JUN PY 1995 VL 10 IS 6 BP 1508 EP 1515 DI 10.1557/JMR.1995.1508 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA QZ899 UT WOS:A1995QZ89900026 ER PT J AU BHATIA, NP EGERLAND, WO AF BHATIA, NP EGERLAND, WO TI REMARKS ON A RESULT OF CARVALHO,L.A.V SO JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS LA English DT Note ID SARKOVSKII ORDER C1 USA,RES LAB,ABERDEEN,MD 21005. RP BHATIA, NP (reprint author), UNIV MARYLAND,CATONSVILLE,MD 21228, USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0022-247X J9 J MATH ANAL APPL JI J. Math. Anal. Appl. PD JUN 1 PY 1995 VL 192 IS 2 BP 669 EP 671 DI 10.1006/jmaa.1995.1196 PG 3 WC Mathematics, Applied; Mathematics SC Mathematics GA RC203 UT WOS:A1995RC20300023 ER PT J AU SATAVA, RM AF SATAVA, RM TI Medical applications of virtual reality SO JOURNAL OF MEDICAL SYSTEMS LA English DT Proceedings Paper CT 2nd NASA/USUHS International Conference on Telemedicine for Remote Health Care and Disaster Response CY SEP 06-10, 1994 CL BETHESDA, MD SP NASA, UNIFORMED SERV UNIV HLTH SCI RP SATAVA, RM (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 36 Z9 39 U1 0 U2 3 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0148-5598 J9 J MED SYST JI J. Med. Syst. PD JUN PY 1995 VL 19 IS 3 BP 275 EP 280 DI 10.1007/BF02257178 PG 6 WC Health Care Sciences & Services; Medical Informatics SC Health Care Sciences & Services; Medical Informatics GA QY386 UT WOS:A1995QY38600005 PM 7643023 ER PT J AU MCNESBY, KL MORRIS, JB AF MCNESBY, KL MORRIS, JB TI FOURIER-TRANSFORM RAMAN-SPECTROSCOPY OF NITROGEN AT HIGH-PRESSURES SO JOURNAL OF RAMAN SPECTROSCOPY LA English DT Note ID CARS AB Re-vibrational and rotational Raman spectra of nitrogen gas at 300 K over the pressure range 3-24 MPa (500-3500 psi) were measured using a Fourier transform spectrometer employing 1064 nm laser radiation as the scattering source, It is shown that the pressure-induced narrowing and peak shift of the Raman spectrum of N-2 observed in these experiments agrees within experimental error with data obtained by other workers using different techniques. RP MCNESBY, KL (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 15 TC 2 Z9 2 U1 0 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0377-0486 J9 J RAMAN SPECTROSC JI J. Raman Spectrosc. PD JUN PY 1995 VL 26 IS 6 BP 487 EP 490 DI 10.1002/jrs.1250260613 PG 4 WC Spectroscopy SC Spectroscopy GA RF563 UT WOS:A1995RF56300012 ER PT J AU EAKLE, WL AF EAKLE, WL TI LESSER KESTRELS OR NOT - A RESPONSE TO HIRALDO ET-AL SO JOURNAL OF RAPTOR RESEARCH LA English DT Editorial Material RP EAKLE, WL (reprint author), USA,CORPS ENGINEERS,REGULATORY BRANCH,211 MAIN ST,SAN FRANCISCO,CA 94105, USA. NR 25 TC 0 Z9 0 U1 0 U2 0 PU RAPTOR RESEARCH FOUNDATION INC PI HASTINGS PA 12805 ST CROIX TRAIL, HASTINGS, MN 55033 SN 0892-1016 J9 J RAPTOR RES JI J. Raptor Res. PD JUN PY 1995 VL 29 IS 2 BP 146 EP 147 PG 2 WC Ornithology SC Zoology GA RG919 UT WOS:A1995RG91900014 ER PT J AU SUMMERS, V LEEK, MR AF SUMMERS, V LEEK, MR TI FREQUENCY GLIDE DISCRIMINATION IN THE F2 REGION BY NORMAL-HEARING AND HEARING-IMPAIRED LISTENERS SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID IDENTIFICATION; RECOGNITION; DURATION; CONSTANT; TONES; CUES RP SUMMERS, V (reprint author), WALTER REED ARMY MED CTR,CTR ARMY AUDIOL & SPEECH,WASHINGTON,DC 20307, USA. FU NIDCD NIH HHS [DC00626] NR 25 TC 4 Z9 4 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUN PY 1995 VL 97 IS 6 BP 3825 EP 3832 DI 10.1121/1.412397 PG 8 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA RD453 UT WOS:A1995RD45300038 PM 7790660 ER PT J AU YOUNG, PC SMACK, DP SAU, P JOHNSON, FB JAMES, WD AF YOUNG, PC SMACK, DP SAU, P JOHNSON, FB JAMES, WD TI GOLF CLUB GRANULOMA SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note C1 WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT CHEM PATHOL,WASHINGTON,DC 20306. RP YOUNG, PC (reprint author), DEWITT ARMY COMMUNITY HOSP,DEPT EMERGENCY MED,FT BELVOIR,VA 22060, USA. NR 6 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JUN PY 1995 VL 32 IS 6 BP 1047 EP 1048 DI 10.1016/0190-9622(95)91358-0 PG 2 WC Dermatology SC Dermatology GA RA344 UT WOS:A1995RA34400021 PM 7751450 ER PT J AU HOCH, AL GUPTA, RK WEYANDT, TB AF HOCH, AL GUPTA, RK WEYANDT, TB TI LABORATORY EVALUATION OF A NEW REPELLENT CAMOUFLAGE FACE PAINT SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article AB A combined formulation of the U.S. Army's camouflage face paints and the new extended duration topical insect/arthropod repellent was tested on human volunteers to determine repellency and duration of protection (2-12 h) against Aedes aegypti and Anopheles stephensi. Under laboratory conditions (27 degrees C and 80% RH), the face paint/repellent formulation provided greater than or equal to 95% repellency or better for up to 6 h for Ae. aegypti and 8 h for An. stephensi. An analysis of variance showed no significant differences in the repellent efficacy of the 4 camouflage colors: white, green, loam, and sand. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. NR 4 TC 13 Z9 13 U1 1 U2 2 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 1995 VL 11 IS 2 BP 172 EP 175 PN 1 PG 4 WC Entomology SC Entomology GA RG306 UT WOS:A1995RG30600004 PM 7595441 ER PT J AU ROBERT, LL PERICH, MJ AF ROBERT, LL PERICH, MJ TI PHLEBOTOMINE SAND FLY (DIPTERA, PSYCHODIDAE) CONTROL USING A RESIDUAL PYRETHROID INSECTICIDE SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID LEISHMANIASIS AB Cyfluthrin was evaluated in the field as a residual insecticide to develop a new strategy for control of Old World phlebotomine sand fly vectors of leishmaniasis, which live and rest inside termite mounds and animal burrows. This insecticide was evaluated as a residual spray in Baringo District, Kenya, during 1993. Termite mounds and animal burrows were treated with a cyfluthrin/corn oil mixture (1.5% AI) using an 8-liter hand-pumped sprayer. Treatment of animal burrows and termite mounds with cyfluthrin provided control of sand flies inside these structures for 12 wk. Numbers of sand fly adults collected in light traps were reduced by up to 90% for 2 wk following treatment. This indicates that cyfluthrin provides short-term area control of adult sand flies when applied to termite mounds and animal burrows. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. RP ROBERT, LL (reprint author), USA,MED RES UNIT,POB 30137,NAIROBI,KENYA. NR 13 TC 9 Z9 9 U1 0 U2 2 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 1995 VL 11 IS 2 BP 195 EP 199 PN 1 PG 5 WC Entomology SC Entomology GA RG306 UT WOS:A1995RG30600008 PM 7595445 ER PT J AU SANDERS, LR AF SANDERS, LR TI EXERCISE-INDUCED ACUTE-RENAL-FAILURE ASSOCIATED WITH IBUPROFEN, HYDROCHLOROTHIAZIDE, AND TRIAMTERENE SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article DE NONSTEROIDAL ANTIINFLAMMATORY DRUGS; DIURETICS; HYPERTENSION; NEPHROSCLEROSIS; PROSTAGLANDINS ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; KIDNEY; RISK AB Nonsteroidal anti-inflammatory drugs predispose to acute renal failure in conditions associated with decreased RBF. Such conditions include advanced age, hypertension, chronic renal insufficiency, diuretic use, and any condition decreasing effective circulating volume. Strenuous exercise also causes marked reductions in RBF. The patient discussed developed severe acute renal failure after strenuous exercise and therapeutic doses of ibuprofen and hydrochlorothiazide-triamterene. Urinalysis showed a nephritic sediment with red blood cell casts. Renal biopsy showed acute tubular necrosis and arteriolar nephrosclerosis. Although exercise-associated acute renal failure is uncommon, susceptible patients with exercise-induced renal ischemia and prostaglandin inhibition may develop this complication. C1 BROOKE ARMY MED CTR,DEPT MED,NEPHROL SERV,FT SAM HOUSTON,TX 78234. NR 20 TC 15 Z9 16 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD JUN PY 1995 VL 5 IS 12 BP 2020 EP 2023 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA RC959 UT WOS:A1995RC95900009 PM 7579049 ER PT J AU BOTROS, BAM SOLIMAN, AK SALIB, AW OLSON, J HIBBS, RG WILLIAMS, JC DARWISH, M ELTIGANI, A WATTS, DM AF BOTROS, BAM SOLIMAN, AK SALIB, AW OLSON, J HIBBS, RG WILLIAMS, JC DARWISH, M ELTIGANI, A WATTS, DM TI COXIELLA-BURNETII ANTIBODY PREVALENCES AMONG HUMAN-POPULATIONS IN NORTHEAST AFRICA DETERMINED BY ENZYME-IMMUNOASSAY SO JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE COXIELLA BURNETII; SEROPREVALENCES; ENZYME IMMUNOASSAY; NORTHEAST AFRICA ID LINKED IMMUNOSORBENT-ASSAY; Q-FEVER; RESPONSES AB Retrospective serosurveys were conducted to determine the prevalence of antibody to phase-I Coxiella burnetii among humans in various locations of north-east Africa. Sera were tested by the enzyme immunoassay (EIA). Initially the EIA was compared with the standard indirect fluorescent antibody (IFA) method for the detection of antibody to C. burnetii. Results indicated that the EIA was slightly less sensitive (88%), but highly specific (94%) and less subjective than the IFA technique. EIA was subsequently adopted for estimating prevalences in the studied human populations. Data obtained by ELA indicated that the prevalence of C. burnetii antibody among adult Egyptian blood donors was 20% (n=358) in the Suez Canal area, 16% (n=501) in the Nile Valley and 10% (n=427) in the Nile Delta. Among adult patients with acute, undifferentiated fever in Egypt, the prevalence was 28% (n=50) of acute sera, with seroconversion in 12% of convalescent sera. Antibody to C. burnetii was detected by ELA in the sera of 25% (n=71) of cattle workers in Egypt, 10% (n=100) of housewives in Sudan, and 37% (n=104) of adults in north-west Somalia. Following a fever outbreak affecting all ages in northern Sudan, IgG antibody to C. burnetii was present in 54% of the febrile persons (n=185) and in 53% of afebrile persons (n=186). IgM antibody to C. burnetii was demonstrated in 29% of the febrile persons and 15% of the afebrile persons. These results implicate C. burnetii as a possibly important and under-reported cause of human disease and undiagnosed fevers in north-east Africa. C1 USN,DIV VIROL,MED RES UNIT 3,CAIRO,EGYPT. CTR DIS CONTROL,ATLANTA,GA. USA,MED RES INST INFECT DIS,DIV BACTERIOL,INTRACELLULAR PATHOGENS BRANCH,FREDERICK,MD 21701. AIN SHAMS UNIV,FAC MED,CAIRO,EGYPT. MINIST HLTH SUDAN,NATL HLTH LABS,KHARTOUM,SUDAN. USN,MED RES INST DETACHMENT,LIMA,PERU. RI Saad, Magdi/H-5561-2013 OI Saad, Magdi/0000-0003-2111-8115 NR 20 TC 6 Z9 6 U1 0 U2 2 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0022-5304 J9 J TROP MED HYG JI J. Trop. Med. Hyg. PD JUN PY 1995 VL 98 IS 3 BP 173 EP 178 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA RD739 UT WOS:A1995RD73900007 PM 7783275 ER PT J AU OPTENBERG, SA WOJCIK, BE THOMPSON, IM AF OPTENBERG, SA WOJCIK, BE THOMPSON, IM TI MORBIDITY AND MORTALITY FOLLOWING RADICAL PROSTATECTOMY - A NATIONAL ANALYSIS OF CIVILIAN HEALTH AND MEDICAL PROGRAM OF THE UNIFORMED SERVICES BENEFICIARIES SO JOURNAL OF UROLOGY LA English DT Article DE PROSTATIC NEOPLASMS; PROSTATECTOMY; MORTALITY; MORBIDITY ID CANCER AB Recent evidence from an analysis of Medicare patients undergoing radical prostatectomy has suggested that perioperative mortality may be substantially greater than that reported in institutional series. To estimate the perioperative mortality and survival of patients of a younger and potentially more representative population of the United States, Civilian Health and Medical Program of the Uniformed Services institutional claims data from October 1, 1987 to January 1, 1993 were analyzed. A total of 1,059 subjects was examined of an average age of 60.0 years and all were younger than 65 years. Using Kaplan-Meier estimates, mortality rates following surgery were calculated to be 0.28% at 30 days, 0.28% at 90 days, 1.02% at 1 year, 1.95% at 2 years, 3.14% at 3 years and 4.64% at 4 years. Observed 1 to 5 mortality rates in this series ranged from 0.362 to 0.487 of the expected mortality when compared to the general population and they were statistically significant. At 30 and 90 days postoperatively 3.1% and 4.6% of the patients were rehospitalized, Data demonstrated that mortality and morbidity from radical prostatectomy were low and that conclusions drawn on outcomes of treatment for carcinoma of the prostate should focus on the entire age range of patients who undergo this procedure in the United States. C1 BROOKE ARMY MED CTR, DEPT UROL, SAN ANTONIO, TX USA. RP OPTENBERG, SA (reprint author), BROOKE ARMY MED CTR, ARMY MED CTR & SCH, CTR HEALTHCARE EDUC & STUDIES, SAN ANTONIO, TX USA. NR 9 TC 26 Z9 28 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD JUN PY 1995 VL 153 IS 6 BP 1870 EP 1872 DI 10.1016/S0022-5347(01)67334-8 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA QX369 UT WOS:A1995QX36900034 PM 7752336 ER PT J AU MCLEOD, DG AF MCLEOD, DG TI EDITORIAL - PROSTATE-CANCER SO JOURNAL OF UROLOGY LA English DT Editorial Material ID PREDICTIVE VALUE; ANTIGEN DENSITY; ENHANCE RP MCLEOD, DG (reprint author), WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307, USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUN PY 1995 VL 153 IS 6 BP 1873 EP 1874 DI 10.1016/S0022-5347(01)67335-X PG 2 WC Urology & Nephrology SC Urology & Nephrology GA QX369 UT WOS:A1995QX36900035 PM 7538600 ER PT J AU BAUER, JJ SESTERHENN, IA COSTABILE, RA AF BAUER, JJ SESTERHENN, IA COSTABILE, RA TI MYXOID LIPOSARCOMA OF THE SCROTAL WALL SO JOURNAL OF UROLOGY LA English DT Note DE SCROTUM; LIPOSARCOMA AB Liposarcomas of the scrotum are rare with 5 cases reported previously. We report a case of myxoid liposarcoma of the scrotal wall, and discuss pathological classification and treatment of genitourinary liposarcomas. C1 ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. RP BAUER, JJ (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307, USA. NR 8 TC 6 Z9 6 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUN PY 1995 VL 153 IS 6 BP 1938 EP 1939 DI 10.1016/S0022-5347(01)67362-2 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA QX369 UT WOS:A1995QX36900062 PM 7752362 ER PT J AU DAWSON, NA MCLEOD, DG AF DAWSON, NA MCLEOD, DG TI DRAMATIC PROSTATE-SPECIFIC ANTIGEN DECREASE IN RESPONSE TO DISCONTINUATION OF MEGESTROL-ACETATE IN ADVANCED PROSTATE-CANCER - EXPANSION OF THE ANTIANDROGEN WITHDRAWAL SYNDROME SO JOURNAL OF UROLOGY LA English DT Note DE PROSTATE; PROSTATIC NEOPLASMS; MEGESTROL; ANDROGEN ANTAGONISTS ID FLUTAMIDE WITHDRAWAL; LNCAP; RECEPTOR; CELLS AB We report a dramatic decrease in prostate specific antigen in response to the discontinuation of megestrol acetate in a patient with progressive metastatic prostate cancer. Our case demonstrates that withdrawal responses may occur with steroidal and nonsteroidal antiandrogens. C1 WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. RP DAWSON, NA (reprint author), WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 11 TC 88 Z9 88 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUN PY 1995 VL 153 IS 6 BP 1946 EP 1947 DI 10.1016/S0022-5347(01)67365-8 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA QX369 UT WOS:A1995QX36900065 PM 7538601 ER PT J AU ZOLLAPAZNER, S OLEARY, J BURDA, S GORNY, MK KIM, M MASCOLA, J MCCUTCHAN, F AF ZOLLAPAZNER, S OLEARY, J BURDA, S GORNY, MK KIM, M MASCOLA, J MCCUTCHAN, F TI SEROTYPING OF PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATES FROM DIVERSE GEOGRAPHIC LOCATIONS BY FLOW-CYTOMETRY SO JOURNAL OF VIROLOGY LA English DT Article ID HUMAN MONOCLONAL-ANTIBODIES; CD4 BINDING-SITE; ENVELOPE GLYCOPROTEIN; IMMUNODOMINANT EPITOPE; HIV-1 GP120; V3 REGION; NEUTRALIZATION; DOMAIN; GP41; SPECIFICITY AB The immunologic relatedness of the various human immunodeficiency virus type 1 (HIV-1) clades was determined with 13 human anti-HIV-1 monoclonal antibodies (MAbs) to six immunogenic regions of the HIV-1 structural proteins, The immunoreactivity of the native, oligomeric viral envelope glycoproteins expressed on the surfaces of human peripheral blood mononuclear cells infected in vitro with primary isolates from clades A through E was determined by flow cytometry. Some epitopes in the immunodominant region of gp41 and the C terminus of gp120 appear to be HIV-1 group specific in that they are expressed on the surfaces of cells in cultures infected with the majority of viruses tested from clades A to E. Epitopes within the V3 region appear to be clade restricted. Surprisingly, one MAb to an epitope in the C terminus of gp120 was entirely clade B specific. Staining with anti-V2 and anti-CD4 binding domain (CD4bd) reagents was infrequently detected. Anti-CD4bd MAbs stained only CD4-negative T cells because the CD4bd of gp120 appeared to be complexed with membrane CD4. When present, the epitopes of V2 and the CD4bd appeared to be expressed on cells infected with various clades. Thus, the results suggest that MAbs to gp41, the C terminus, and the V3 loop of gp120 are most useful in serotyping primary isolates of HIV-1, providing group-specific, clade-restricted, and clade-specific reagents. The use of the immunofluorescent method with the reagents described herein distinguishes infection with clade B from that with all other HIV-1 clades. With additional MAbs, this technique will allow a broadly applicable, reproducible, and practical method for serotyping HIV-1. C1 NYU,MED CTR,NEW YORK,NY 10016. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. HENRY M JACKSON FDN MIL MED,ROCKVILLE,MD 20850. RP ZOLLAPAZNER, S (reprint author), VET AFFAIRS MED CTR,423 E 23RD ST,ROOM 18124N,NEW YORK,NY 10010, USA. FU NIAID NIH HHS [AI 32424, AI 27742, AI 36085] NR 57 TC 78 Z9 78 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD JUN PY 1995 VL 69 IS 6 BP 3807 EP 3815 PG 9 WC Virology SC Virology GA QX931 UT WOS:A1995QX93100064 PM 7745728 ER PT J AU GRATE, JW ABRAHAM, MH DU, CM MCGILL, RA SHUELY, WJ AF GRATE, JW ABRAHAM, MH DU, CM MCGILL, RA SHUELY, WJ TI EXAMINATION OF VAPOR SORPTION BY FULLERENE, FULLERENE-COATED SURFACE-ACOUSTIC-WAVE SENSORS, GRAPHITE, AND LOW-POLARITY POLYMERS USING LINEAR SOLVATION ENERGY RELATIONSHIPS SO LANGMUIR LA English DT Article ID PARTITION-COEFFICIENTS; STATIONARY PHASES; K-VALUES; GAS; SOLUBILITY; RESPONSES; COATINGS; DESIGN; TETRACHLOROMETHANE; MICROSENSORS AB The sorption of vapors by fullerene is compared with the sorption of vapors by an assembled fullerene thin film on a surface acoustic wave vapor sensor. A linear solvation energy relationship derived for solid fullerene at 298 K was used to calculate gas/solid partition coefficients for the same vapors as those examined using the vapor sensor. This relationship correctly predicted; the relative vapor sensitivities observed with the vapor sensor. A new linear solvation energy relationship for vapor adsorption by graphite at 298 K has been determined, and solid fullerene and solid graphite are found to be quite similar in their vapor sorption properties. Comparisons have also been made with linear organic and inorganic polymers, including poly(isobutylene), poly(epichlorohydrin), OV25, and OV202. In all cases, sorption is driven primarily by dispersion interactions. The assembled fullerene material is generally similar in vapor selectivity to the other nonpolar sorbent materials considered but yields less sensitive vapor sensors than linear organic polymers. C1 UCL, DEPT CHEM, LONDON WC1H 0AJ, ENGLAND. GEOCENTERS INC, FT WASHINGTON, MD 20744 USA. USA, EDGEWOOD RES DEV & ENGN CTR, SCBRDRT, ABERDEEN PROVING GROUND, MD 21010 USA. RP PACIFIC NW LAB, ENVIRONM MOLEC SCI LAB, RICHLAND, WA 99352 USA. NR 39 TC 58 Z9 58 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD JUN PY 1995 VL 11 IS 6 BP 2125 EP 2130 DI 10.1021/la00006a046 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA RF223 UT WOS:A1995RF22300047 ER PT J AU BEITLER, RM AF BEITLER, RM TI CONFRONTING THE COSTS OF WAR - MILITARY POWER, STATE, AND SOCIETY IN EGYPT AND ISRAEL - BARNETT,MN SO MIDDLE EAST JOURNAL LA English DT Book Review RP BEITLER, RM (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INSTITUTE PI WASHINGTON PA 1761 N STREET NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD SUM PY 1995 VL 49 IS 3 BP 525 EP 526 PG 2 WC Area Studies SC Area Studies GA RX628 UT WOS:A1995RX62800021 ER PT J AU Martins, MS AF Martins, MS TI ''War crimes'' during operations other than war: Military doctrine and law fifty years after Nuremberg - And beyond SO MILITARY LAW REVIEW LA English DT Article; Proceedings Paper CT Conference on Nuremberg and the Rule of Law - A 50-Year Verdict CY NOV 17-18, 1995 CL JUDGE ADVOCATE GENERALS SCH, USA, CHARLOTTESVILLE, VA SP Univ Virginia, Ctr Natl Secur Law, Duke Univ Sch Law, Ctr Law Ethics & Natl Secur, USA, Judge Advocate Generals Sch, Ctr Law & Mil Operat HO JUDGE ADVOCATE GENERALS SCH, USA ID PROTOCOL-I RP Martins, MS (reprint author), USA, WASHINGTON, DC 20310 USA. NR 108 TC 3 Z9 3 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1995 VL 149 BP 145 EP 187 PG 43 WC Law SC Government & Law GA UQ798 UT WOS:A1995UQ79800016 ER PT J AU Elliott, HW AF Elliott, HW TI Global survival - Ferencz,BB SO MILITARY LAW REVIEW LA English DT Book Review C1 USA,JUDGE ADVOCATE GEN SCH,INT LAW DIV,CHARLOTTESVILLE,VA 22901. NR 8 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1995 VL 149 BP 303 EP 309 PG 7 WC Law SC Government & Law GA UQ798 UT WOS:A1995UQ79800025 ER PT J AU Morris, LJ AF Morris, LJ TI Nuremberg: Infamy on trial - Persico,J SO MILITARY LAW REVIEW LA English DT Book Review RP Morris, LJ (reprint author), USA,JUDGE ADVOCATE GEN SCH,CRIMINAL LAW DEPT,CHARLOTTESVILLE,VA 22901, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1995 VL 149 BP 310 EP 311 PG 2 WC Law SC Government & Law GA UQ798 UT WOS:A1995UQ79800026 ER PT J AU JIGGETTS, SM HALL, DP AF JIGGETTS, SM HALL, DP TI HELPING THE HELPER - 528TH COMBAT STRESS CENTER IN SOMALIA SO MILITARY MEDICINE LA English DT Article AB Seventy-three Rangers were injured and 18 were killed after an ambush in Somalia, Members of the 46th Combat Support Hospital provided nearly continuous care to the wounded soldiers over the subsequent 36 hours, Members of the 528th Combat Stress Center provided psychological support to hospital personnel. Those who provide emergency services to trauma victims are often neglected in terms of the emotional trauma they experience in caring for the injured. This article describes the use of critical incident stress debriefings as a means to reduce distress in the wake of mass-casualty care. RP JIGGETTS, SM (reprint author), COMBAT SUPPORT HOSP 28,CTR COMBAT STRESS 528,FT BRAGG,NC 28307, USA. NR 0 TC 4 Z9 4 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1995 VL 160 IS 6 BP 275 EP 277 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA RJ152 UT WOS:A1995RJ15200002 PM 7659221 ER PT J AU KRAGH, JF TAYLOR, DC AF KRAGH, JF TAYLOR, DC TI FAST-ROPING INJURIES AMONG ARMY RANGERS - A RETROSPECTIVE SURVEY OF AN ELITE AIRBORNE BATTALION SO MILITARY MEDICINE LA English DT Article AB 3Fast-roping is a modified rappelling technique used by civilian and military special operations forces that frequently produces injuries, Highly classified until recently, fast-roping is poorly understood from a medical perspective. This paper presents a brief description of fast-roping and a retrospective survey of the types of fast-roping injuries sustained in a U.S. Army Ranger battalion. Injuries are similar to parachute landing fall injuries, but show a greater propensity for ankle injuries (30% of all injuries), The mechanisms of injury include landing injuries after a controlled descent and falls from a great height when an individual loses control of the rope. RP KRAGH, JF (reprint author), EISENHOWER ARMY MED CTR,DEPT SURG,DIV ORTHOPAED,FT GORDON,GA 30905, USA. NR 0 TC 4 Z9 4 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1995 VL 160 IS 6 BP 277 EP 279 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA RJ152 UT WOS:A1995RJ15200003 PM 7659222 ER PT J AU RABIN, J AF RABIN, J TI TIME-LIMITED VISUAL RESOLUTION IN PILOT TRAINEES SO MILITARY MEDICINE LA English DT Article AB Superior vision is needed for piloting aircraft in military and civilian environments, Although visual evaluations of potential pilots typically are conducted with no limit on viewing time, aviation and related occupations require superior vision under time-limited viewing conditions, and assessment of this capability is needed, The purpose of this study was to evaluate time-limited visual resolution in pilot trainees. A forced-choice letter recognition task was used to measure visual acuity (VA) and small letter contrast sensitivity (SLCS) in 37 trainees who had satisfied all vision requirements for pilot training. VA and SLCS were highly correlated (r = 0.76), indicating that the two tests measure similar aspects of visual resolution, However, although VA scores were distributed across 0.16 log units (two lines of letters on a VA chart), SLCS scores varied across 0.35 log units, which is nearly four lines on the SLCS chart, The variation in SLCS performance could be explained, in part, by subtle refractive error in pilot trainees, The results exemplify differences in performance among visually qualified trainees, and underscore the need for proper refractive correction, SLCS is a useful screening test for identifying subtle changes in vision that herald the need for optical or medical intervention. RP RABIN, J (reprint author), USA,AEROMED RES LAB,DIV AIRCREW HLTH & PERFORMANCE,FT RUCKER,AL 36362, USA. NR 0 TC 2 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1995 VL 160 IS 6 BP 279 EP 283 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA RJ152 UT WOS:A1995RJ15200004 PM 7659223 ER PT J AU GREENE, P CHISICK, MC AF GREENE, P CHISICK, MC TI CHILD-ABUSE NEGLECT AND THE ORAL HEALTH OF CHILDRENS PRIMARY DENTITION SO MILITARY MEDICINE LA English DT Article AB This paper compares oral health status and presence of untreated, decayed primary teeth in 42 confirmed cases of child abuse with 822 non-abused controls. The 864 children (ages 3-11) came from military families at one Army installation, We assessed oral health status using the dfs (decayed and filled surfaces) index and derived presence of untreated, decayed teeth from the decayed and unfilled component of each child's dfs score, Using logistic regression, we determined the influence of abuse status and other sociodemographic characteristics on both outcome measures. Results show that abuse status does not contribute to differences in oral health status, but it does contribute to differences in presence of untreated, decayed primary teeth, Abused children with sponsors assigned to non-combat units are 5.2 times more likely to have untreated, decayed primary teeth than other children, These results suggest that military child abuse intervention efforts should include referral for dental care plus the need to target younger children from families with non-combatant sponsors. RP GREENE, P (reprint author), USA,FT STEWART,GA 31314, USA. NR 0 TC 12 Z9 12 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1995 VL 160 IS 6 BP 290 EP 293 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA RJ152 UT WOS:A1995RJ15200007 PM 7659226 ER PT J AU GAYDOS, CA GAYDOS, JC AF GAYDOS, CA GAYDOS, JC TI ADENOVIRUS VACCINES IN THE US MILITARY SO MILITARY MEDICINE LA English DT Article AB Acute respiratory disease (ARD) due to adenoviruses caused significant morbidity in military training populations, Since 1971 ARD has been controlled by the use of live, enteric-coated, adenovirus (ADV) types 4 and 7 vaccines, This immunization program overcame significant problems in vaccine development, Due to a production delay, military training posts stopped ADV vaccine administration in spring 1994, The delivery of ADV vaccine resumed in late February 1995, but another production delay is anticipated, A generation of military medical people have not been exposed to the significant morbidity caused by adenoviruses and are unaware of the effectiveness of the ADV vaccine. ARD morbidity before ADV vaccines, the ADV Vaccine development program, and current issues regarding the control of ARD due to adenoviruses in the military are discussed. RP GAYDOS, CA (reprint author), USA,CTR HLTH PROMOT & PREVENT MED PROVIS,ABERDEEN PROVING GROUND,MD 21010, USA. RI Gaydos, Charlotte/E-9937-2010 NR 0 TC 89 Z9 92 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1995 VL 160 IS 6 BP 300 EP 304 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA RJ152 UT WOS:A1995RJ15200010 PM 7659229 ER PT J AU BERIGAN, TR HOLZGANG, A AF BERIGAN, TR HOLZGANG, A TI VALPROATE AS AN ALTERNATIVE IN POSTTRAUMATIC-STRESS-DISORDER - A CASE-REPORT SO MILITARY MEDICINE LA English DT Note RP BERIGAN, TR (reprint author), TRIPLER ARMY MED CTR,DEPT PSYCHIAT,HONOLULU,HI 96859, USA. NR 0 TC 15 Z9 16 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1995 VL 160 IS 6 BP 318 EP 318 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA RJ152 UT WOS:A1995RJ15200014 PM 7659233 ER PT J AU YOUNG, RJ BODT, BA HEITKAMP, DH AF YOUNG, RJ BODT, BA HEITKAMP, DH TI ACTION OF METALLIC-IONS ON THE PRECOCIOUS DEVELOPMENT BY RABBIT SPERM OF MOTION PATTERNS THAT ARE CHARACTERISTIC OF HYPERACTIVATED MOTILITY SO MOLECULAR REPRODUCTION AND DEVELOPMENT LA English DT Article DE METALLIC IONS; HYPERACTIVATION; MOTILITY ID HEXAVALENT CHROMIUM; ACROSOME REACTION; MOVEMENT CHARACTERISTICS; OXYGEN-CONSUMPTION; EPIDIDYMAL SPERM; MAMMALIAN SPERM; TERM EXPOSURE; LEAD ACETATE; INVITRO; SPERMATOZOA AB An earlier study demonstrated that rabbit sperm incubated for 16 hr under capacitation conditions acquire motility patterns identical to those seen in rabbit sperm capacitated in vivo. We now show that similar motion patterns develop after 0.5 hr incubation in a Tris-buffered medium, medium M. Development and decline of the motion patterns occurred in three phases each recognized by the character of the biphasic motion patterns. Hyperactivated sperm were objectively identified and quantified by a previously developed computer-directed model. The percentage of motile sperm that acquired hyperactivated motility and the period they remained in this state varied among sperm from different rabbits. The decline in hyperactivated motility was paralleled by a decrease in the average sperm curvilinear velocity (VCL) and average amplitude of lateral head displacement (AALH), but was not accompanied by a concomitant decrease in percentage of motile sperm. Pb2+ and Cd2+, at concentrations that did not inhibit motility, prevented development of hyperactivated motility. Inhibition of hyperactivated motility by Pb2+ was time- and concentration-dependent; the average percentage of hyperactivated sperm decreased from similar to 30% to <5% (n = 5) in 1 hr at a Pb2+ concentration of 25 mu M. Cd2+ inhibition of hyperactivation was dependent only on concentration of the cation. At a concentration of 100 mu M, the decrease in the percent of hyperactivated sperm was similar to 50% (n = 3). Hg2+, Zn2+, and Cr6+ at sublethal concentrations had no effect on hyperactivated motility development. These results suggest that Pb2+ and Cd2+, by virtue of their ability to prevent the wide curvature flagella beating that is characteristic of hyperactivation, can compromise fertilization at concentrations that do not inhibit sperm motility and act as a reproductive toxicant at a level other than spermatogenesis. (C) 1995 Wiley-Liss, Inc. C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD. RP YOUNG, RJ (reprint author), EDGEWOOD RES DEV & ENGN CTR,DEPT LIFE SCI,APPL TOXICOL TEAM,SCBRD RTL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 63 TC 7 Z9 7 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 1040-452X J9 MOL REPROD DEV JI Mol. Reprod. Dev. PD JUN PY 1995 VL 41 IS 2 BP 239 EP 248 DI 10.1002/mrd.1080410215 PG 10 WC Biochemistry & Molecular Biology; Cell Biology; Developmental Biology; Reproductive Biology SC Biochemistry & Molecular Biology; Cell Biology; Developmental Biology; Reproductive Biology GA RB090 UT WOS:A1995RB09000014 PM 7654377 ER PT J AU BRACKEN, J AF BRACKEN, J TI LANCHESTER MODELS OF THE ARDENNES CAMPAIGN SO NAVAL RESEARCH LOGISTICS LA English DT Article AB A detailed data base of the Ardennes campaign of World War II (December 15, 1944 through January 16, 1945) has recently been developed. The present article formulates four Lanchester models of the campaign and estimates their parameters for these data. Two-sided time histories of warfare on battles and campaigns are very rare, so Lanchester models have seldom been validated with historical data. The models are homogeneous in that tanks, armored personnel carriers, artillery, and manpower are weighted to yield a measure of strength of the Allied and German forces. This weighting is utilized for combat power and for losses. The models treat combat forces in the campaign( including infantry, armor, and artillery manpower) and total forces in the campaign (including both combat manpower and support manpower.) Four models are presented. Two models have five parameters (Allied individual effectiveness, German individual effectiveness, exponent of shooting force, exponent of target force, and a tactical parameter reflecting which side is defending and attacking.) The other two models remove the tactical parameter, which is not generally known prior to warfare, and estimate the other parameters without the tactical parameter. The main results of the research are (a) the Lanchester linear model fits the Ardennes campaign data in all four cases, and (b) when combat forces are considered Allied individual effectiveness is greater than German individual effectiveness, whereas when total forces are considered Allied and German individual effectiveness is the same. The interpretation of the latter result is that the two sides had essentially the same individual capabilities but were organized differently-the Allies chose to have more manpower in the support forces, which yielded greater individual capabilities in the combat forces. The overall superiority of the Allies in the campaign led to the attrition to the Allies being a smaller portion of their forces. (C) 1995 John Wiley and Sons, Inc. C1 YALE UNIV,NEW HAVEN,CT 06520. USA,CONCEPTS ANALYSTS AGCY,WASHINGTON,DC 20310. NR 33 TC 24 Z9 28 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD JUN PY 1995 VL 42 IS 4 BP 559 EP 577 DI 10.1002/1520-6750(199506)42:4<559::AID-NAV3220420405>3.0.CO;2-R PG 19 WC Operations Research & Management Science SC Operations Research & Management Science GA QT543 UT WOS:A1995QT54300003 ER PT J AU HARTLEY, DS HELMBOLD, RL AF HARTLEY, DS HELMBOLD, RL TI VALIDATING LANCHESTERS SQUARE LAW AND OTHER ATTRITION MODELS SO NAVAL RESEARCH LOGISTICS LA English DT Article AB This article addresses the question of validating the homogeneous Lanchestrian square law of attrition by the use of historical data (and by extension, other attrition models). Validating an attrition model means testing that model against reality. In this case, Lanchester's square law is tested against the data from the Inchon-Seoul campaign of the Korean War. The data are examined using three analysis techniques: linear regression, the Akaike Information Criterion (AIC), and Bozdogan's Consistent AIC (CAIC). The data do not fit the assumption of a single, constant coefficient, homogeneous square law battle. The data do fit a set of three such battles (a new one every six or seven days); however, the data fit three constant-casualty-model battles just as well. The homogeneous Lanchester square law cannot be regarded as a proven attrition algorithm for warfare; however, the square law cannot be regarded as disproved either. Data on more battles are required to validate the square law or any other proposed attrition law. (C) 1995 John Wiley and Sons, Inc. C1 USA,CONCEPTS ANAL AGCY,CSCA MVM,WASHINGTON,DC. RP HARTLEY, DS (reprint author), MARTIN MARIETTA ENERGY SYST INC,DATA SYST RES & DEV,PIKETON,OH 45661, USA. NR 26 TC 24 Z9 25 U1 0 U2 1 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD JUN PY 1995 VL 42 IS 4 BP 609 EP 633 DI 10.1002/1520-6750(199506)42:4<609::AID-NAV3220420408>3.0.CO;2-W PG 25 WC Operations Research & Management Science SC Operations Research & Management Science GA QT543 UT WOS:A1995QT54300006 ER PT J AU HELMBOLD, RL AF HELMBOLD, RL TI RATES OF ADVANCE IN LAND COMBAT OPERATIONS SO NAVAL RESEARCH LOGISTICS LA English DT Review AB This article presents some of the highlights from a study of rates of advance in land combat operations, conducted between mid-1989 and mid-1990. It describes how the basic information was obtained, indicates how that information was used to compose the data bases, comments on the major features of past work on this subject, and summarizes our own analyses and interpretations of the data. (C) 1995 John Wiley and Sons, Inc. RP HELMBOLD, RL (reprint author), USA,CONCEPTS ANAL AGCY,8120 WOODMONT AVE,BETHESDA,MD 20814, USA. NR 106 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD JUN PY 1995 VL 42 IS 4 BP 635 EP 669 DI 10.1002/1520-6750(199506)42:4<635::AID-NAV3220420409>3.0.CO;2-O PG 35 WC Operations Research & Management Science SC Operations Research & Management Science GA QT543 UT WOS:A1995QT54300007 ER PT J AU ARANDA, FJ RAO, DVGLN WONG, CL ZHOU, P CHEN, Z AKKARA, JA KAPLAN, DL ROACH, JF AF ARANDA, FJ RAO, DVGLN WONG, CL ZHOU, P CHEN, Z AKKARA, JA KAPLAN, DL ROACH, JF TI NONLINEAR-OPTICAL INTERACTIONS IN BACTERIORHODOPSIN USING Z-SCAN SO OPTICAL REVIEW LA English DT Article DE BACTERIORHODOPSIN; Z-SCAN; NONLINEAR; OPTICS ID FILMS AB Nonlinear refractive index coefficient n(2) of bacteriorhodopsin suspensions in water is measured by the Z-scan technique with a low power continuous wave laser at 647.1 manometer wavelength. Our results indicate that both the magnitude and the sign of n(2) depend strongly on the light intensity. Negative values for n(2) are obtained for on axis laser irradiance at the focus above 3 W/cm(2). The observed self-defocusing phenomena can be attributed to the index change due to the light induced transition between the photochromic states. The results elucidate the origin of n(2) and offer a plausible explanation for the differences in the reported n(2) measurements. C1 USA, NATICK RES DEV & ENGN CTR, NATICK, MA 01760 USA. RP UNIV MASSACHUSETTS, DEPT PHYS, BOSTON, MA 02125 USA. RI Rao, Devulapalli/L-8863-2015 NR 10 TC 12 Z9 12 U1 0 U2 0 PU OPTICAL SOC JAPAN PI TOKYO PA KUDAN-KITA BLDG 5F, 1-12-3, KUDAN-KITA CHIYODA-KU, TOKYO, 102, JAPAN SN 1340-6000 EI 1349-9432 J9 OPT REV JI Opt. Rev. PD JUN-JUL PY 1995 VL 2 IS 3 BP 204 EP 206 DI 10.1007/s10043-995-0204-x PG 3 WC Optics SC Optics GA RW690 UT WOS:A1995RW69000011 ER PT J AU MAEL, FA ASHFORTH, BE AF MAEL, FA ASHFORTH, BE TI LOYAL FROM DAY ONE - BIODATA, ORGANIZATIONAL IDENTIFICATION, AND TURNOVER AMONG NEWCOMERS SO PERSONNEL PSYCHOLOGY LA English DT Article; Proceedings Paper CT 1994 Academy-of-Management Meeting CY 1994 CL DALLAS, TX SP Acad Management ID EMPLOYEE TURNOVER; SOCIAL IDENTITY; COMMITMENT; MODEL; SELF; METAANALYSIS; ANTECEDENTS; BEHAVIOR AB This paper attempts to use biodata to uncover behavioral and experiential antecedents of organizational identification (OID), and to demonstrate one way in which theory can be used in the development and analysis of objective biodata. The biodata correlates of organizational identification were assessed with a sample of 2,535 new U.S. Army recruits. Four biodata factors emerged: activities involving outdoor work or pastimes; a dependable, non-delinquent, lifestyle reflecting socialization to institutional expectations; a general preference for group attachments; and diligent involvement in intellectual pastimes. Results with a subset of 1,082 recruits revealed that both OID and the biodata antecedents predicted subsequent attrition across 6 time periods spanning 6 to 24 months. Results also revealed relatively high OID among the recruits. C1 CONCORDIA UNIV,DEPT MANAGEMENT,MONTREAL,PQ,CANADA. RP MAEL, FA (reprint author), USA,RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 90 TC 229 Z9 234 U1 7 U2 44 PU PERSONNEL PSYCHOLOGY INC PI BOWLING GREEN PA 745 HASKINS ROAD, SUITE A, BOWLING GREEN, OH 43402 SN 0031-5826 J9 PERS PSYCHOL JI Pers. Psychol. PD SUM PY 1995 VL 48 IS 2 BP 309 EP 333 DI 10.1111/j.1744-6570.1995.tb01759.x PG 25 WC Psychology, Applied; Management SC Psychology; Business & Economics GA RD887 UT WOS:A1995RD88700004 ER PT J AU MCDONOUGH, JH SHIH, TM AF MCDONOUGH, JH SHIH, TM TI A STUDY OF THE N-METHYL-D-ASPARTATE ANTAGONISTIC PROPERTIES OF ANTICHOLINERGIC DRUGS SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE MOUSE; N-METHYL-D-ASPARTATE; LETHALITY; ANTICHOLINERGIC DRUG; N-METHYL-D-ASPARTATE ANTAGONISTS; ANTI-PARKINSONIAN DRUGS ID SOMAN-INDUCED SEIZURES; PHENCYCLIDINE-LIKE DRUGS; INDUCED LETHALITY; RAT; ACETYLCHOLINE; CONVULSIONS; HIPPOCAMPUS; INVOLVEMENT; DIAZEPAM; AGENTS AB Drugs that act at the N-methyl-D-aspartate (NMDA) receptor complex have the ability to terminate nerve agent-induced seizures and modulate the neuropathologic consequences of agent exposure. Drugs with mixed anticholinergic and anti-NMDA properties potentially provide an ideal class of compounds for development as anticonvulsant treatments for nerve agent casualties. The present experiment evaluated the potential NMDA antagonist activity of 11 anticholinergic drugs by determining whether pretreatment with the compound was capable of protecting mice from the lethal effects of NMDA. The following anticholinergic drugs antagonized NMDA lethality and are ranked according to their potency: mecamylamine > procyclidine = benactyzine > biperiden > trihexyphenidyl. The anticholinergics atropine, aprophen, azaprophen, benztropine, 3-quinuclidinyl benzilate (QNB), and scopolamine failed to show NMDA antagonist properties. In addition, and unexpectedly, diazepam, ethanol, and pentobarbital were also shown to be capable of antagonizing NMDA lethality over a certain range of doses. The advantages and limitations of using antagonism of NMDA lethality in mice as a bioassay for determining the NMDA antagonist properties of drugs are also discussed. RP MCDONOUGH, JH (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,MCMR UV PA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 26 TC 67 Z9 69 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD JUN-JUL PY 1995 VL 51 IS 2-3 BP 249 EP 253 DI 10.1016/0091-3057(94)00372-P PG 5 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA RB491 UT WOS:A1995RB49100013 PM 7667336 ER PT J AU BAUMAN, RA KANT, GJ AF BAUMAN, RA KANT, GJ TI TIME COST OF ALTERNATION REDUCED DEMAND FOR FOOD IN A CLOSED ECONOMY SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE FEEDING; CIRCADIAN RHYTHMS; LEVER PRESS; RAT; MEAL SIZE ID BEHAVIORAL ECONOMICS; FEEDING PATTERNS; RATS AB A principal purpose of the present study was to characterize rats' demand for food by increasing the required delay between the alternation of leverpresses. While living in cages that were exposed to a 12:12 light:dark cycle, rats were required to alternate leverpresses for their entire daily food ration. After a press on one lever resulted in the delivery of a food pellet, a red cuelight was illuminated for a fixed duration that equaled the imposed delay between successive leverpresses. After the imposed delay elapsed and the cuelight was turned off, a press on the alternate lever resulted in the delivery of another food pellet. Increases in the imposed delay from 0.01 s to 16 s reduced mean percent correct (alternation) and mean food intake, although both were reduced more rapidly and to a greater extent in the light than in the dark photoperiod. This interaction resulted from a reduction of meal size in the light and a compensatory increase in meal size in the dark as the imposed delay increased. Rats also defended their daily intake in the dark against increasingly larger imposed delays by spending increasingly larger amounts of time alternating and by increasing total (correct + incorrect) presses. These results suggest that photoperiod is a determinant of the motivational value of food as a reinforcer for instrumental behavior in a closed economy. RP BAUMAN, RA (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,PHYSIOL & BEHAV BRANCH,WASHINGTON,DC 20307, USA. NR 19 TC 8 Z9 8 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD JUN PY 1995 VL 57 IS 6 BP 1187 EP 1193 DI 10.1016/0031-9384(95)00038-K PG 7 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA QY764 UT WOS:A1995QY76400026 PM 7652042 ER PT J AU CASTRO, CA AF CASTRO, CA TI PRIMACY AND RECENCY EFFECTS IN RHESUS-MONKEYS (MACACA-MULATTA) USING A SERIAL PROBE RECOGNITION TASK .1. EFFECTS OF DIAZEPAM SO PSYCHOPHARMACOLOGY LA English DT Article DE RHESUS MONKEY; DIAZEPAM; SERIAL PROBE RECOGNITION TASK ID INTRAVENOUS DIAZEPAM; MEMORY; BENZODIAZEPINES; SCOPOLAMINE; TRIAZOLAM; INDUCTION; HYOSCINE; AMNESIA; AGENTS; DRUGS AB In this study, we evaluated the effects of diazepam (0.2, 0.8, 1.6 and 3.2 mg/kg; IM) on the primacy and recency memory effects in four rhesus monkeys trained on a six-item serial probe recognition (SPR) task. Only the highest dose of diazepam (3.2 mg/kg) consistently affected the shape of the monkeys' serial position curves. Accuracy on the probe trials was disrupted for list items which occurred in the middle portion and recency memory component of the serial position curve, without affecting the primacy component. Diazepam, however, also produced several nonspecific effects on SPR performance. Both the 1.6 and 3.2 mg/kg diazepam doses disrupted accuracy on the non-matching probe trials, and the 3.2 mg/kg dose caused an increase in response latencies which were unrelated to any one component of the serial position curve. This is the first demonstration in nonhuman primates showing that the primacy and recency memory effects can be differentiated on the basis of diazepam dose. C1 USA,MED RES INST CHEM DEF,DIV DRUG ASSESMENT,ABERDEEN,MD 21010. NR 36 TC 19 Z9 19 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0033-3158 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PD JUN PY 1995 VL 119 IS 4 BP 421 EP 427 DI 10.1007/BF02245858 PG 7 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA RG451 UT WOS:A1995RG45100010 PM 7480522 ER PT J AU LILLYCROP, WJ ESTEP, LL AF LILLYCROP, WJ ESTEP, LL TI GENERATIONAL ADVANCEMENTS IN COASTAL SURVEYING, MAPPING SO SEA TECHNOLOGY LA English DT Article RP LILLYCROP, WJ (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,DIV ENGN DEV,SHOALS PROGRAM,VICKSBURG,MS 39180, USA. RI Wright, Dawn/A-4518-2011 OI Wright, Dawn/0000-0002-2997-7611 NR 6 TC 4 Z9 4 U1 0 U2 0 PU COMPASS PUBL INC PI ARLINGTON PA SUITE 1000 1117 N 19 ST, ARLINGTON, VA 22209 SN 0093-3651 J9 SEA TECHNOL JI Sea Technol. PD JUN PY 1995 VL 36 IS 6 BP 10 EP & PG 0 WC Engineering, Ocean SC Engineering GA RE910 UT WOS:A1995RE91000002 ER PT J AU KRISHNAMURTI, C MAGLASANG, P KEYT, BA ALVING, BM AF KRISHNAMURTI, C MAGLASANG, P KEYT, BA ALVING, BM TI COMPARISON OF THE FIBRINOLYTIC EFFICACIES OF WILD TYPE-T-PA AND VARIANT T-PA IN PREVENTING FIBRIN DEPOSITION IN ENDOTOXIN-TREATED RABBITS WITH ELEVATED PAI-1 LEVELS SO THROMBOSIS AND HAEMOSTASIS LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307. GENENTECH INC,S SAN FRANCISCO,CA 94080. NR 0 TC 0 Z9 0 U1 0 U2 0 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD JUN PY 1995 VL 73 IS 6 BP 1336 EP 1336 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA RP385 UT WOS:A1995RP38501670 ER PT J AU LARSON, MJ BOWERSOX, JC LIM, RC HESS, JR AF LARSON, MJ BOWERSOX, JC LIM, RC HESS, JR TI EFFICACY OF A FIBRIN HEMOSTATIC BANDAGE IN CONTROLLING HEMORRHAGE FROM EXPERIMENTAL ARTERIAL INJURIES SO THROMBOSIS AND HAEMOSTASIS LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC. NR 0 TC 1 Z9 1 U1 0 U2 0 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD JUN PY 1995 VL 73 IS 6 BP 1465 EP 1465 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA RP385 UT WOS:A1995RP38502155 ER PT J AU BRIMFIELD, AA AF BRIMFIELD, AA TI POSSIBLE PROTEIN PHOSPHATASE INHIBITION BY BIS(HYDROXYETHYL)SULFIDE, A HYDROLYSIS PRODUCT OF MUSTARD GAS SO TOXICOLOGY LETTERS LA English DT Article DE SULFUR MUSTARD; P-NITROPHENYL PHOSPHATE; CANTHARIDIN; PROTEIN PHOSPHATASES; BIS(HYDROXYETHYL)SULFIDE ID OKADAIC ACID; CANTHARIDIN; SPECIFICITY; KINETICS AB Recently, the natural vesicant cantharidin was shown to bind exclusively to and inhibit protein phosphatase 2A (PP2A) in mouse tissue extracts (Li and Casida (1992) Proc. Natl. Acad. Sci. USA 89, 11867-11870). To explore the generality of this effect in vesicant action, we measured the protein serine/threonine phosphatase activity in mouse liver cytosol (in the form of the okadaic acid inhibitable increment of p-nitrophenyl phosphate (p-NPP) phosphatase activity) in the presence of aqueous sulfur mustard or its hydrolysis product, bis(hydroxyethyl)sulfide (TDG). Sulfur mustard inhibited p-NPP hydrolysis. However, inhibition correlated with the time elapsed between thawing and the addition of mustard to the enzyme preparation, not with concentration. TDG exhibited a direct, concentration-related inhibition of p-NPP hydrolysis between 30 and 300 mu M. We conclude that sulfur mustard also has an inhibitory effect on protein serine/threonine phosphatases. However, the inhibition is an effect of its non-alkykating hydrolysis product TDG, not of sulfur mustard itself. RP BRIMFIELD, AA (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 12 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCI PUBL IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD JUN PY 1995 VL 78 IS 1 BP 43 EP 48 DI 10.1016/0378-4274(94)03228-Y PG 6 WC Toxicology SC Toxicology GA RE628 UT WOS:A1995RE62800006 PM 7604398 ER PT J AU FRANCIS, B SCHMIDT, J YANG, Y ORLANDO, R KAISER, II AF FRANCIS, B SCHMIDT, J YANG, Y ORLANDO, R KAISER, II TI ANIONS AND THE ANOMALOUS GEL-FILTRATION BEHAVIOR OF NOTEXIN AND SCUTOXIN SO TOXICON LA English DT Article ID NOTECHIS-SCUTATUS-SCUTATUS; AMINO-ACID-SEQUENCE; AUSTRALIAN TIGER SNAKE; CROTALUS-SCUTULATUS-SCUTULATUS; VIPERA-AMMODYTES-AMMODYTES; VENOM CONSTITUENTS; CERASTES-CERASTES; BOTHROPS-ASPER; PHOSPHOLIPASE-A2; INHIBITOR AB Based on their mol. wts, notexin and scutoxin elute later than expected from gel filtration columns in multiple peaks [Francis et al. (1991) Toxicon 29, 85-96]. Notexins present in these peaks have identical amino acid sequences and unmodified amino acid side-chains. Scutoxin is an isoform of notexin which contains arginine at position 16 and glutamate at position 82. Like notexin, it also elutes in different fractions on a gel filtration column, yet the fractions show identical amino acid sequence. This perplexing chromatographic behavior appears to be caused by the association of these proteins with different anions, since dissolving notexin in buffers containing different anions produces up to a 30% change in elution volume. Certain anions promote an apparent reduction in the interaction of notexin with gel filtration matrix, hence earlier elution. These anions include citrate, 3-phosphoglycerate and 2-phosphoglycerate, which also inhibit the PLA, activity of notexin. However, even under conditions which minimize protein-matrix interaction the toxins elute later than expected based on their mol. wt. C1 UNIV WYOMING,DEPT MOLEC BIOL,LARAMIE,WY 82071. USA,MED RES INST INFECT DIS,DIV TOXINOL,FREDERICK,MD 21701. UNIV GEORGIA,COMPLEX CARBOHYDRATE RES CTR,ATHENS,GA 30602. FU NCRR NIH HHS [5-P41-RR0535] NR 28 TC 5 Z9 5 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD JUN PY 1995 VL 33 IS 6 BP 779 EP 789 DI 10.1016/0041-0101(95)00015-E PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA RD672 UT WOS:A1995RD67200007 PM 7676469 ER PT J AU BOSLEGO, J GARCIA, J CRUZ, C ZOLLINGER, W BRANDT, B RUIZ, S MARTINEZ, M ARTHUR, J UNDERWOOD, P SILVA, W MORAN, E HANKINS, W GILLY, J MAYS, J AF BOSLEGO, J GARCIA, J CRUZ, C ZOLLINGER, W BRANDT, B RUIZ, S MARTINEZ, M ARTHUR, J UNDERWOOD, P SILVA, W MORAN, E HANKINS, W GILLY, J MAYS, J TI EFFICACY, SAFETY, AND IMMUNOGENICITY OF A MENINGOCOCCAL GROUP-B (15-P1.3) OUTER-MEMBRANE PROTEIN VACCINE IN IQUIQUE, CHILE SO VACCINE LA English DT Article DE NEISSERIA MENINGITIDIS; VACCINE; EFFICACY TRIAL; NONCOVALENT COMPLEX ID NEISSERIA-MENINGITIDIS; POLYSACCHARIDE; ANTIBODIES; DISEASE; COMPLEX AB A meningococcal group B (15:P1.3) outer membrane protein vaccine was tested for efficacy in a randomized, double-blind controlled study in Iquique, Chile. A total of 40 811 volunteers, ages 1-21 years, enrolled in the study. Volunteers received two doses of vaccine six weeks apart by jet injector. Both the experimental vaccine and the control vaccine (Menomune(R), A, C, Y and W135 meningococcal polysaccharide vaccine) were well tolerated with minor side-effects. Active surveillance for suspected cases of meningococcal disease was conducted for 20 months in Iquique. Eighteen cases of group B meningococcal disease were confirmed during the 20 months. Efficacy was estimated to be 51% (p=0.11) for all ages combined. In children aged 1-4 no protection was evident, but in volunteers aged 5-21 vaccine efficacy was 70% (p=0.045). The IgG antibody response by ELISA was characterized by a large booster effect after the second dose, followed by a substantial drop in antibody levels by 6 months. The youngest children had the highest responses. The bactericidal antibody response, on the other hand, was characterized by the lack of a significant booster response, higher responses in the older children, and an increase in the geometric mean titer in the later months of the study in the older children. C1 INST SALUD PUBL CHILE,SANTIAGO,CHILE. MINIST SALUD,SANTIAGO,CHILE. CONNAUGHT LABS LTD,SWIFTWATER,PA 18370. RP BOSLEGO, J (reprint author), WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. RI Cruz, Celia/K-3977-2013 OI Cruz, Celia/0000-0001-8922-5713 NR 28 TC 187 Z9 189 U1 0 U2 9 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA LINACRE HOUSE JORDAN HILL, OXFORD, OXON, ENGLAND OX2 8DP SN 0264-410X J9 VACCINE JI Vaccine PD JUN PY 1995 VL 13 IS 9 BP 821 EP 829 DI 10.1016/0264-410X(94)00037-N PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA RL566 UT WOS:A1995RL56600007 PM 7483804 ER PT J AU KIM, BJ QI, SY AF KIM, BJ QI, SY TI HAZARDOUS-WASTE TREATMENT TECHNOLOGIES SO WATER ENVIRONMENT RESEARCH LA English DT Review AB This review emphasizes hazardous waste treatment technologies cited in 1994 references. Note that the technologies directly related to groundwater, radioactive wastes, and special industrial wastes may also be found elsewhere in this volume. This review consists of four parts: general, biological treatment, chemical/physical treatment, and thermal treatment. RP KIM, BJ (reprint author), USA,CONSTRUCT ENGN RES LABS,ATTN CECER EP,POB 9005,CHAMPAIGN,IL 61826, USA. RI Qi, Shaoying/A-2837-2008 NR 186 TC 2 Z9 2 U1 0 U2 1 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 SN 1061-4303 J9 WATER ENVIRON RES JI Water Environ. Res. PD JUN PY 1995 VL 67 IS 4 BP 560 EP 570 DI 10.2175/106143095X135859 PG 11 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA RH543 UT WOS:A1995RH54300026 ER PT J AU MOSSMAN, DJ ROIG, LC MONTGOMERY, MA AF MOSSMAN, DJ ROIG, LC MONTGOMERY, MA TI MIXING AND TRANSPORT SO WATER ENVIRONMENT RESEARCH LA English DT Review C1 USA, CORPS ENGINEERS, HYDRAUL LAB, WATERWAYS EXPT STN, VICKSBURG, MS 39180 USA. RP UNIV MISSOURI, DEPT CIVIL ENGN CEP, 5100 ROCKHILL RD, KANSAS CITY, MO 64110 USA. NR 330 TC 0 Z9 0 U1 0 U2 1 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA SN 1061-4303 EI 1554-7531 J9 WATER ENVIRON RES JI Water Environ. Res. PD JUN PY 1995 VL 67 IS 4 BP 597 EP 613 DI 10.2175/106143095X135886 PG 17 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA RH543 UT WOS:A1995RH54300029 ER PT J AU GALLOWAY, GE AF GALLOWAY, GE TI NEW DIRECTIONS IN FLOODPLAIN MANAGEMENT SO WATER RESOURCES BULLETIN LA English DT Article DE FLOODPLAIN MANAGEMENT; FLOODS; 1993 MISSISSIPPI RIVER FLOOD; WATER POLICY; FLOOD CONTROL; NONSTRUCTURAL; FLOODPLAINS; FLOOD REPORT AB Over the last 30 years, average annual riverine flood damages have exceed $2 billion. Damages associated with the Mississippi River Flood of 1993 exceeded $12 billion and these costs do not include the non-quantifiable, human impacts of this disaster. In a report submitted to the White House in June 1994, a federal interagency floodplain management review committee proposed better ways to manage the nation's floodplains. The committee indicated that the 1993 Mississippi River flood was the result of a significant hydrometeorological event, that federal flood control efforts in the Mississippi basin had prevented nearly $20 billion in potential damages, and that, in spite of federal flood damage reduction efforts, throughout the nation people and property remain at risk to inevitable future flooding. It recommended that the division of decision and cost-sharing responsibilities among federal, state and local governments be more clearly defined, and that the nation adopt a strategy of, sequentially, avoiding inappropriate use of the floodplain, minimizing vulnerability to damage through both nonstructural and structural means, and mitigating damages as they occur. The report did not call for abandonment of human use of the floodplain but argued for full consideration of the economic, social and environmental costs and benefits of all future floodplain activity. C1 US MIL ACAD,EXECUT OFF PRESIDENT,INTERAGCY FLOODPLAIN MANAGEMENT REVIEW COMM,W POINT,NY 10996. RP GALLOWAY, GE (reprint author), US MIL ACAD,ACAD BOARD,TAYLOR HALL,W POINT,NY 10996, USA. NR 0 TC 5 Z9 5 U1 0 U2 6 PU AMER WATER RESOURCES ASSOC PI HERNDON PA 950 HERNDON PARKWAY SUITE 300, HERNDON, VA 22070-5528 SN 0043-1370 J9 WATER RESOUR BULL JI Water Resour. Bull. PD JUN PY 1995 VL 31 IS 3 BP 351 EP 357 PG 7 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA RF309 UT WOS:A1995RF30900002 ER PT J AU KROL, MF LEAVITT, RP PHAM, JT MCGINNIS, BP PEYGHAMBARIAN, N AF KROL, MF LEAVITT, RP PHAM, JT MCGINNIS, BP PEYGHAMBARIAN, N TI ENHANCED ELECTROABSORPTION IN SELECTIVELY DOPED (GA,IN)AS/AL,IN)AS ASYMMETRIC DOUBLE-QUANTUM WELLS SO APPLIED PHYSICS LETTERS LA English DT Article C1 USA,RES LAB,ADELPHI,MD 20783. UNIV ARIZONA,CTR OPT SCI,TUCSON,AZ 85721. RP KROL, MF (reprint author), ROME LAB,CTR PHOTON,GRIFFISS AFB,NY 13441, USA. NR 15 TC 11 Z9 12 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 29 PY 1995 VL 66 IS 22 BP 3045 EP 3047 DI 10.1063/1.114272 PG 3 WC Physics, Applied SC Physics GA QZ888 UT WOS:A1995QZ88800041 ER PT J AU WONG, RSY WIRTZ, RA HANCOCK, REW AF WONG, RSY WIRTZ, RA HANCOCK, REW TI PSEUDOMONAS-AERUGINOSA OUTER-MEMBRANE PROTEIN OPRF AS AN EXPRESSION VECTOR FOR FOREIGN EPITOPES - THE EFFECTS OF POSITIONING AND LENGTH ON THE ANTIGENICITY OF THE EPITOPE SO GENE LA English DT Note DE RECOMBINANT DNA; GENETIC FUSION; HYBRID PROTEIN; SURFACE EXPOSURE; PEPTIDE PRESENTATION ID PLASMODIUM-FALCIPARUM; MONOCLONAL-ANTIBODIES; ESCHERICHIA-COLI; PERMISSIVE SITES; IMMUNOGENICITY; SURFACE; DETERMINANTS; PREDICTION; SEQUENCES; PEPTIDES AB OprF, the major outer membrane (OM) protein of Pseudomonas aeruginosa, has been proposed to be comprised of a series of beta-strands separated by periplasmic or surface-exposed loop regions. In this study, a simple malarial epitope was used to demonstrate that OprF can be used as an expression vector to present foreign peptide sequences, namely, the 4-amino-acid (aa) repeating epitope (Asn-Ala-Asn-Pro = NANP) of the circumsporozoite protein of the human malarial parasite Plasmodium falciparum. Eight permissive sites, that allowed the expression and surface exposure of the malarial epitope, were identified throughout OprF. Using a monoclonal antibody (mAb) specific for the malarial epitope, we investigated the effects of positioning and length of the epitope on its antigenicity in the OprF expression vector system. It was demonstrated that the malarial epitope inserted at aa(26) was significantly more reactive with the epitope-specific mAb (i.e., more antigenic) when assayed in the context of whole cells whereas those at aa(213) and aa(290) were more antigenic when assayed in the OM. The malarial epitope inserted at aa(188) and aa(196) was moderately antigenic, while this epitope inserted at aa(215) and aa(310) showed low antigenicity with the same mAb in both whole cell and OM assays. For two insertion sites, aa(26) and aa(213), we demonstrated that the insertion of multiple copies of the epitope enhanced reactivity with the malarial epitope-specific mAb. These data are discussed with respect to the local OprF sequences into which the epitope was inserted. C1 UNIV BRITISH COLUMBIA,DEPT MICROBIOL & IMMUNOL,VANCOUVER,BC V6T 1Z3,CANADA. WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. RI Hancock, Robert/E-1145-2013 NR 20 TC 32 Z9 32 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1119 J9 GENE JI Gene PD MAY 26 PY 1995 VL 158 IS 1 BP 55 EP 60 DI 10.1016/0378-1119(95)00155-Y PG 6 WC Genetics & Heredity SC Genetics & Heredity GA RE879 UT WOS:A1995RE87900008 PM 7540583 ER PT J AU EVALDSSON, PA TAYLOR, GW COOKE, P JIANG, S AF EVALDSSON, PA TAYLOR, GW COOKE, P JIANG, S TI INVERSION CHANNEL VERTICAL-CAVITY DOUBLE-HETEROSTRUCTURE OPTOELECTRONIC SWITCH LASERS SO ELECTRONICS LETTERS LA English DT Article DE PHOTONIC SWITCHING; VERTICAL CAVITY SURFACE EMITTING LASERS ID SURFACE-EMITTING LASERS; QUANTUM-WELL; GROWTH AB Inversion channel technology provides a straightforward way to integrate lasers with detectors and transistors. One inversion channel laser is the double heterostructure optoelectronic switch VCSEL which is reported here with a 2.1mA threshold for a 10 mu m diameter device. A deposited stack of SiO2/TiO2 was used with post-growth etching of the cavity. Excellent electrical switching parameters of V-sw = 13V, V-h = 2.1V and I-h = 0.5mA were obtained, making the device suitable for the digital optoelectronic sensing of small optical inputs. C1 UNIV CONNECTICUT,DEPT ELECT & SYST ENGN,STORRS,CT 06269. USA,RES LAB,FT MONMOUTH,NJ 07724. INTELLIGENT AUTOMAT INC,ROCKVILLE,MD 20850. RP EVALDSSON, PA (reprint author), ROYAL INST TECHNOL,S-10044 STOCKHOLM,SWEDEN. NR 12 TC 4 Z9 4 U1 0 U2 0 PU IEE-INST ELEC ENG PI HERTS PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTS, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD MAY 25 PY 1995 VL 31 IS 11 BP 920 EP 921 DI 10.1049/el:19950581 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA RC656 UT WOS:A1995RC65600057 ER PT J AU GORBUNOV, NV OSIPOV, AN DAY, BW ZAYASRIVERA, B KAGAN, VE ELSAYED, NM AF GORBUNOV, NV OSIPOV, AN DAY, BW ZAYASRIVERA, B KAGAN, VE ELSAYED, NM TI REDUCTION OF FERRYLMYOGLOBIN AND FERRYLHEMOGLOBIN BY NITRIC-OXIDE - A PROTECTIVE MECHANISM AGAINST FERRYL HEMOPROTEIN-INDUCED OXIDATIONS SO BIOCHEMISTRY LA English DT Article ID ELECTRON-SPIN-RESONANCE; TERT-BUTYL HYDROPEROXIDE; RED-BLOOD-CELLS; RIBONUCLEOTIDE REDUCTASE; PERITONEAL-MACROPHAGES; LIPID-PEROXIDATION; MAMMALIAN-CELLS; VITAMIN-E; MYOGLOBIN; SUPEROXIDE AB The reactions of metmyoglobin (metMb) and methemoglobin (metHb), oxidized to their respective oxoferryl free radical species ((.)Mb-Fe-IV=O/(.)Hb-4Fe(IV)=O) by tert-butyl hydroperoxide (t-BuOOH), with nitric oxide (NO.) were studied by a combination of optical, electron spin resonance (ESR), ionspray mass (MS), fluorescence, and chemiluminescence spectrometries to gain insight into the mechanism by which NO. protects against oxidative injury produced by (.)Mb-Fe-IV=O/(.)Hb-4Fe(IV)=O. Oxidation of metMb/metHb by t-BuOOH in a nitrogen atmosphere proceeded via the formation of two protein electrophilic centers, which were heme oxoferryl and the apoprotein radical centered at tyrosine (for the (.)Mb-Fe-IV=O form, the g value was calculated to be 2.0057), and was accompanied by the formation of t-BuOOH-derived tert-butyl(per)oxyl radicals. We hypothesized that NO. may reduce both oxoferryl and apoprotein free radical electrophilic centers of (.)Mb-Fe-IV=O/(.)Hb-4Fe(IV)=O and eliminate tert-butyl(per)oxyl radicals, thus protecting against oxidative damage. We found that NO. reduced (.)Mb-Fe-IV=O/(.)Hb-4Fe(IV)=O to their respective ferric (met) forms and prevented the following: (i) oxidation of cis-parinaric acid (PnA) in liposomes, (ii) oxidation of luminol, and (iii) formation of the tert-butyl(per)oxyl adduct with the spin trap DMPO. NO. eliminated the signals of tyrosyl radical detected by ESR and oxoferryl detected by MS in the reaction of t-BuOOH with metMb. As evidenced by MS of apomyoglobin, this effect was due to the two-electron reduction of (.)Mb-Fe-IV=O by NO. at the oxoferryl center rather than to nitrosylation of the tyrosine residues. Results of our in vitro experiments suggest that NO. exhibits a patent, targetable antioxidant effect against oxidative damage produced by oxoferryl Mb/Hb. C1 UNIV PITTSBURGH,DEPT ENVIRONM & OCCUPAT HLTH,PITTSBURGH,PA 15238. UNIV PITTSBURGH,DEPT PHARMACEUT SCI,PITTSBURGH,PA 15238. UNIV PITTSBURGH,PITTSBURGH CANC INST,PITTSBURGH,PA 15238. UNIV CALIF LOS ANGELES,DEPT ENVIRONM & OCCUPAT HLTH SCI,LOS ANGELES,CA 90024. RP GORBUNOV, NV (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT RESP RES,DIV MED,WASHINGTON,DC 20307, USA. FU NHLBI NIH HHS [HL 51469] NR 61 TC 96 Z9 97 U1 2 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA PO BOX 57136, WASHINGTON, DC 20037-0136 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD MAY 23 PY 1995 VL 34 IS 20 BP 6689 EP 6699 DI 10.1021/bi00020a014 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA QZ902 UT WOS:A1995QZ90200014 PM 7756300 ER PT J AU FOLKES, PA DUTTA, M RUDIN, S SHEN, H ZHOU, W SMITH, D TAYSINGLARA, M NEWMAN, P COLE, M AF FOLKES, PA DUTTA, M RUDIN, S SHEN, H ZHOU, W SMITH, D TAYSINGLARA, M NEWMAN, P COLE, M TI EXCITONIC RECOMBINATION OF DEGENERATE 2-DIMENSIONAL ELECTRONS WITH LOCALIZED PHOTOEXCITED HOLES IN A SINGLE-HETEROJUNCTION QUANTUM-WELL - REPLY SO PHYSICAL REVIEW LETTERS LA English DT Note ID GAS RP FOLKES, PA (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAY 22 PY 1995 VL 74 IS 21 BP 4356 EP 4356 DI 10.1103/PhysRevLett.74.4356 PG 1 WC Physics, Multidisciplinary SC Physics GA QZ236 UT WOS:A1995QZ23600067 ER PT J AU CARRIERI, AH LIM, PI AF CARRIERI, AH LIM, PI TI NEURAL-NETWORK PATTERN-RECOGNITION OF THERMAL-SIGNATURE SPECTRA FOR CHEMICAL DEFENSE SO APPLIED OPTICS LA English DT Article DE THERMOLUMINESCENCE; NEURAL NETWORK; PATTERN RECOGNITION; VIBRATIONAL SPECTRA; REMOTE DETECTION AB We treat infrared patterns of absorption or emission by nerve and blister agent compounds (and simulants of this chemical group) as features for the training of neural networks to detect the compounds' liquid layers on the ground or their vapor plumes during evaporation by external heating. Training of a four-layer network architecture is composed of a backward-error-propagation algorithm and a gradient-descent paradigm. We conduct testing by feed-forwarding preprocessed spectra through the network in a scaled format consistent with the structure of the training-data-set representation. The best-performance weight matrix (spectral filter) evolved from final network training and testing with software simulation trials is electronically transferred to a set of eight artificial intelligence integrated circuits (ICs') in specific modular form (splitting of weight matrices). This form makes full use of all input-output IC nodes. This neural network computer serves an important real-time detection function when it is integrated into pre- and postprocessing data-handling units of a tactical prototype thermoluminescence sensor now under development at the Edgewood Research, Development, and Engineering Center. RP CARRIERI, AH (reprint author), USA,CHEM & BIOL DEF COMMAND,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010, USA. NR 15 TC 11 Z9 11 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAY 20 PY 1995 VL 34 IS 15 BP 2623 EP 2635 PG 13 WC Optics SC Optics GA QZ042 UT WOS:A1995QZ04200003 PM 21052402 ER PT J AU FLANIGAN, DF AF FLANIGAN, DF TI VAPOR-DETECTION SENSITIVITY AS A FUNCTION OF SPECTRAL RESOLUTION FOR A SINGLE LORENTZIAN BAND SO APPLIED OPTICS LA English DT Article AB The objective of this effort is to provide guidance for the determination of spectral resolution for the passive remote detection of organic vapors. Target bands were modeled as Lorentzian bands. Several sensor models were used, including a detector-limited sensor model and a background-limited model. An expression for the signal-to-noise ratio (SNR) was derived, and the SNR was computed for an SFs target band. The results show that substantial gains in sensitivity are possible if the conventional laboratory spectral resolution of 2 cm(-1) is reduced to 8 or even 16 cm(-1). RP FLANIGAN, DF (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010, USA. NR 14 TC 16 Z9 16 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAY 20 PY 1995 VL 34 IS 15 BP 2636 EP 2639 PG 4 WC Optics SC Optics GA QZ042 UT WOS:A1995QZ04200004 PM 21052403 ER PT J AU FLANIGAN, DF AF FLANIGAN, DF TI DISCREPANCIES BETWEEN 2 FORMULATIONS OF SIGNAL-TO-NOISE RATIO FOR BACKGROUND-LIMITED DETECTION SO APPLIED OPTICS LA English DT Note DE SIGNAL-TO-NOISE RATIO; INFRARED; FOURIER TRANSFORM SPECTROSCOPY; SQUARE-LAW DETECTOR AB Different investigators have published different relationships for the same problem of predicting the signal-to-noise ratio for incoherent, passive detection of infrared radiation. The results of two authors are compared, and a possible basis for the differences is explained. RP FLANIGAN, DF (reprint author), USA,ARMY EDGEWOOD RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 8 TC 1 Z9 1 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAY 20 PY 1995 VL 34 IS 15 BP 2721 EP 2723 PG 3 WC Optics SC Optics GA QZ042 UT WOS:A1995QZ04200018 PM 21052417 ER PT J AU VASQUEZ, GB REDDY, G GILLILAND, GL STEVENS, WJ AF VASQUEZ, GB REDDY, G GILLILAND, GL STEVENS, WJ TI DINITROBENZENE INDUCES METHEMOGLOBIN FORMATION FROM DEOXYHEMOGLOBIN IN-VITRO SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article DE DINITROBENZENE; METHEMOGLOBIN; DEOXYHEMOGLOBIN; OXYHEMOGLOBIN; CARBOXYHEMOGLOBIN ID AUTOXIDATION; MECHANISM; HEMOGLOBIN; RATS; MYOGLOBIN; TOXICITY AB The reaction of hemoglobin (Hb) with dinitrobenzenes (DNBs) was studied to develop a molecular-level understanding of such reactions that will enhance the development of toxicokinetic models that employ Hb adducts as biomarkers for exposure. Methemoglobin (metHb) is formed during the reaction and UV/VIS spectroscopy was used to follow the reaction of DNB isomers with deoxy-(dxHb), oxy-(HbO(2)) and carboncarboxy-(HbCO) hemoglobin. HPLC chromatography of dxHb treated with radiolabelled DNB was employed to detect possible adduct formation. Deconvolution of the spectra and the presence of well-defined isobestic points imply that DNB induces a direct conversion of dxHb to metHb, but little or no conversion occurs for either HbCO or HbO(2). This implies that the reaction of DNB with Hb may require direct access to the heme and/or that the reaction is initiated by oxidation of the heme, which occurs more readily in the deoxy state. Labelled DNB formed no detectable covalent Hb adducts in the presence of dxHb, providing evidence that metHb formation is not linked to adduct formation. C1 NIST,CTR ADV RES BIOTECHNOL,ROCKVILLE,MD 20850. UNIV MARYLAND,MARYLAND BIOTECHNOL INST,ROCKVILLE,MD 20850. USA,BIOMED R&D LAB,FT DETRICK,MD 21702. NR 18 TC 6 Z9 6 U1 0 U2 2 PU ELSEVIER SCI PUBL IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD MAY 19 PY 1995 VL 96 IS 2 BP 157 EP 171 DI 10.1016/0009-2797(94)03590-5 PG 15 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA QV678 UT WOS:A1995QV67800006 PM 7728905 ER PT J AU DAI, N CAVUS, A DZAKPASU, R TAMARGO, MC SEMENDY, F BAMBHA, N HWANG, DM CHEN, CY AF DAI, N CAVUS, A DZAKPASU, R TAMARGO, MC SEMENDY, F BAMBHA, N HWANG, DM CHEN, CY TI MOLECULAR-BEAM EPITAXIAL-GROWTH OF HIGH-QUALITY ZN1-XCDXSE ON INP SUBSTRATES SO APPLIED PHYSICS LETTERS LA English DT Article ID GREEN LASER-DIODES; BLUE; LAYERS C1 USA,RES LAB,FT BELVOIR,VA 22060. BELLCORE,RED BANK,NJ 07701. RP DAI, N (reprint author), CUNY CITY COLL,DEPT CHEM,NEW YORK,NY 10031, USA. NR 11 TC 26 Z9 26 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 15 PY 1995 VL 66 IS 20 BP 2742 EP 2744 DI 10.1063/1.113694 PG 3 WC Physics, Applied SC Physics GA QY400 UT WOS:A1995QY40000047 ER PT J AU JOHNSTONE, PAS RIFFENBURGH, R SAUNDERS, EL WILLISON, FW AF JOHNSTONE, PAS RIFFENBURGH, R SAUNDERS, EL WILLISON, FW TI GRADING INACCURACIES IN DIAGNOSTIC BIOPSIES REVEALING PROSTATIC ADENOCARCINOMA - IMPLICATIONS FOR DEFINITIVE RADIATION-THERAPY SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Note DE GLEASON SCORE; HISTOPATHOLOGY; PROGNOSIS; PROSTATE CANCER; RADIOTHERAPY; TUMOR GRADE ID PROSTATECTOMY SPECIMENS; RADICAL PROSTATECTOMY; TUMOR GRADE; CANCER; ACCURACY AB Purpose: A critical determinant of prognosis in prostate cancer is grade of disease. Historically, this has been determined by biopsy of the prostate using transperineal, transrectal, or transurethral approaches. Several reports in the literature reveal that these biopsies often underestimate the histologic grade of the tumor when compared with subsequent radical prostatectomy specimens. Methods and Materials: Data from the literature were analyzed to assess the magnitude of this bias towards undergrading. Grade of biopsy specimens (well-differentiated = Gleason scare 2-4; moderately differentiated = Gleason 5-7; poorly differentiated = Gleason 8-10) were correlated with the ultimate prostatectomy grade, Analysis was made of tendency to undergrade specimens using strict criteria of data inclusion for needle biopsies, and more relaxed criteria for all types of prostate biopsies. Results: Grading accuracy from needle biopsies was 71%, with 23% undergraded and 6% overgraded. A chi-square test on equal chance of under- vs. overgrading yielded p = 0.022. Grading accuracy from needle, open perineal, and transurethral biopsies was 65%, with 23% undergraded and 12% overgraded. A similar chi-square test yielded p = 0.007. In both cases, there appears to exist a significant bias towards undergrading. Conclusions: In addition to other well-documented factors that confound comparisons between radiation therapy and surgical series in carcinoma of the prostate, grade migration exists as well. The equivalence of radiation therapy and surgery with respect to overall survival in this disease is accomplished despite these biases. C1 WALTER REED ARMY MED CTR,RADIAT ONCOL SERV,WASHINGTON,DC. USN,MED CTR,DIV RADIAT ONCOL,SAN DIEGO,CA 92134. RP JOHNSTONE, PAS (reprint author), USN,MED CTR,DEPT CLIN INVEST,SAN DIEGO,CA 92134, USA. NR 18 TC 18 Z9 18 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD MAY 15 PY 1995 VL 32 IS 2 BP 479 EP 482 DI 10.1016/0360-3016(94)00619-V PG 4 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA RA038 UT WOS:A1995RA03800023 PM 7751188 ER PT J AU MICKEVICIUS, R MITIN, V KOCHELAP, V STROSCIO, MA IAFRATE, GJ AF MICKEVICIUS, R MITIN, V KOCHELAP, V STROSCIO, MA IAFRATE, GJ TI RADIATION OF ACOUSTIC PHONONS FROM QUANTUM WIRES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ELECTRON; SCATTERING; EMISSION; REGIME; GAAS C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. UKRAINIAN ACAD SCI,INST SEMICOND,KIEV,UKRAINE. RP MICKEVICIUS, R (reprint author), WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48202, USA. NR 20 TC 10 Z9 10 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 15 PY 1995 VL 77 IS 10 BP 5095 EP 5097 PG 3 WC Physics, Applied SC Physics GA QY839 UT WOS:A1995QY83900031 ER PT J AU COLE, MW HAN, WY CASAS, LM JONES, KA AF COLE, MW HAN, WY CASAS, LM JONES, KA TI A MATERIALS STUDY OF PTTIGEPD OHMIC CONTACTS TO P(+)-ALGAAS AS A FUNCTION OF ANNEALING TEMPERATURE SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID N-GAAS; P-GAAS; STABILITY RP COLE, MW (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 12 TC 7 Z9 7 U1 1 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 15 PY 1995 VL 77 IS 10 BP 5225 EP 5230 DI 10.1063/1.359272 PG 6 WC Physics, Applied SC Physics GA QY839 UT WOS:A1995QY83900055 ER PT J AU BARTH, J AF BARTH, J TI THE RETIREMENT MYTH - WHAT YOU MUST KNOW TO PROSPER IN THE COMING MELTDOWN OF JOB SECURITY, PENSION PLANS, SOCIAL-SECURITY, THE STOCK-MARKET, HOUSING PRICES, AND MORE - KARPEL,C SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD MAY 15 PY 1995 VL 120 IS 9 BP 80 EP 80 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA QX750 UT WOS:A1995QX75000164 ER PT J AU PEARTON, SJ ABERNATHY, CR VARTULI, CB MACKENZIE, JD SHUL, RJ WILSON, RG ZAVADA, JM AF PEARTON, SJ ABERNATHY, CR VARTULI, CB MACKENZIE, JD SHUL, RJ WILSON, RG ZAVADA, JM TI HYDROGEN INCORPORATION IN GAN, ALN, AND INN DURING CL-2/CH4/H-2/AR ECR PLASMA-ETCHING SO ELECTRONICS LETTERS LA English DT Article DE REACTIVE ION ETCHING; PASSIVATION AB Hydrogen concentrations up to similar to 10(20)cm(-3) in GaN and AIN and similar to 10(19)cm(-3) in InN are found to be incorporated during ECR plasma etching in Cl-2/CH4/H2Ar at 170 degrees C. Even very short duration (40s) etch treatments produce hydrogen incorporation depths greater than or equal to 0.2 mu m ahead of the etch front, and may lead to electrical passivation effects within this region. Post-etch annealing at 450-500 degrees C restores the initial conductivity. C1 SANDIA NATL LABS,ALBUQUERQUE,NM 87185. HUGHES RES LABS,MALIBU,CA 90265. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP PEARTON, SJ (reprint author), UNIV FLORIDA,GAINESVILLE,FL 32611, USA. NR 9 TC 18 Z9 18 U1 0 U2 5 PU IEE-INST ELEC ENG PI HERTS PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTS, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD MAY 11 PY 1995 VL 31 IS 10 BP 836 EP 837 DI 10.1049/el:19950558 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA RA565 UT WOS:A1995RA56500049 ER PT J AU CAMPBELL, CS CLEARY, PW HOPKINS, M AF CAMPBELL, CS CLEARY, PW HOPKINS, M TI LARGE-SCALE LANDSLIDE SIMULATIONS - GLOBAL DEFORMATION, VELOCITIES AND BASAL FRICTION SO JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH LA English DT Article ID LONG RUNOUT LANDSLIDES; COMPUTER-SIMULATION; SELF-LUBRICATION; AVALANCHE; FLOWS; FLUIDIZATION AB The cause of the apparent small friction exhibited by long runout landslides has long been speculated upon. In an attempt to provide some insight into the matter, this paper describes results obtained from a discrete particle computer simulation of landslides composed of up to 1,000,000 two-dimensional discs. While simplified, the results show many of the characteristics of field data (the volumetric effect on runout, preserved strata, etc.) and with allowances made for the two-dimensional nature of the simulation, the runouts compare well with those of actual landslides. The results challenge the current view that landslides travel as a nearly solid block riding atop a low friction basal layer. Instead, they show that the mass is completely shearing and indicate that the apparent friction coefficient is an increasing function of shear rate. The volumetric effect can then be understood. With all other conditions being equal, different size slides appear to travel with nearly the same average velocity; however, as the larger landslides are thicker, they experience smaller shear rates and correspondingly smaller frictional resistance. C1 COMMONWEALTH SCI & IND RES ORG, DIV MATH & STAT, CLAYTON, VIC, AUSTRALIA. USA, COLD REG RES & ENGN LAB, HANOVER, NH 03755 USA. RP CAMPBELL, CS (reprint author), UNIV SO CALIF, DEPT MECH ENGN, OLIN HALL 430, LOS ANGELES, CA 90089 USA. RI Campbell, Charles/C-3653-2008; Cleary, Paul/E-3965-2010 OI Cleary, Paul/0000-0002-6481-3284 NR 34 TC 170 Z9 179 U1 1 U2 19 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9313 EI 2169-9356 J9 J GEOPHYS RES-SOL EA JI J. Geophys. Res.-Solid Earth PD MAY 10 PY 1995 VL 100 IS B5 BP 8267 EP 8283 DI 10.1029/94JB00937 PG 17 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA QX769 UT WOS:A1995QX76900016 ER PT J AU BLANCK, RR AF BLANCK, RR TI ILL LEGAL SO NATION LA English DT Letter RP BLANCK, RR (reprint author), USA,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU NATION CO INC PI NEW YORK PA 72 FIFTH AVE, NEW YORK, NY 10011 SN 0027-8378 J9 NATION JI Nation PD MAY 8 PY 1995 VL 260 IS 18 BP 618 EP 618 PG 1 WC Political Science SC Government & Law GA QU675 UT WOS:A1995QU67500008 ER PT J AU KUDLICKI, W ODOM, OW KRAMER, G HARDESTY, B MERRILL, GA HOROWITZ, PM AF KUDLICKI, W ODOM, OW KRAMER, G HARDESTY, B MERRILL, GA HOROWITZ, PM TI THE IMPORTANCE OF THE N-TERMINAL SEGMENT FOR DNAJ-MEDIATED FOLDING OF RHODANESE WHILE BOUND TO RIBOSOMES AS PEPTIDYL-TRANSFER-RNA SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID BOVINE LIVER RHODANESE; TRANSCRIPTION TRANSLATION; BINDING AB Two lines of evidence indicate the importance of the N-terminal portion of rhodanese for correct folding of the nascent ribosome-bound polypeptide. A mutant gene lacking the codons for amino acids 1-23 of the wild-type protein is expressed very efficiently by coupled transcription/translation on Escherichia coli ribosomes; however, the mutant protein that is released from the ribosomes is enzymatically inactive. The mutant protein does not undergo the reaction that is promoted by the bacterial chaperone, DnaJ, which appears to be essential for folding of ribosome-bound rhodanese into the native conformation, The effect of DnaJ is monitored by fluorescence from coumarin cotranslationally incorporated at the N terminus of nascent rhodanese. Secondly, a synthetic peptide corresponding to the N-terminal 17 amino acids of the wild-type protein interferes with the synthesis of wild-type rhodanese but has much less effect on the synthesis of the N-terminal deletion mutant. The N-terminal peptide inhibits the effect of DnaJ on the nascent wild-type rhodanese and blocks the chaperone-mediated release and activation of ribosome-bound full-length rhodanese polypeptides that accumulate during in, vitro synthesis. The results lead to the hypothesis that the N-terminal segment of rhodanese is required for its chaperone-dependent folding on the ribosome. C1 UNIV TEXAS, DEPT CHEM & BIOCHEM, AUSTIN, TX 78712 USA. BROOKE ARMY MED CTR, DEPT CLIN INVEST, FT SAM HOUSTON, TX 78234 USA. UNIV TEXAS, HLTH SCI CTR, DEPT BIOCHEM, SAN ANTONIO, TX 78284 USA. FU NIEHS NIH HHS [ES05729]; NIGMS NIH HHS [GM25177] NR 27 TC 25 Z9 26 U1 0 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 EI 1083-351X J9 J BIOL CHEM JI J. Biol. Chem. PD MAY 5 PY 1995 VL 270 IS 18 BP 10650 EP 10657 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA QW601 UT WOS:A1995QW60100045 PM 7738002 ER PT J AU MATHER, B AF MATHER, B TI PROPERTIES OF CONCRETE USING CRUSHED CLINKER BRICK AS COARSE AGGREGATE SO ACI MATERIALS JOURNAL LA English DT Discussion RP MATHER, B (reprint author), USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 INTERNATIONAL WAY, COUNTRY CLUB DRIVE, PO BOX 9094, FARMINGTON HILLS, MI 48333-9094 SN 0889-325X J9 ACI MATER J JI ACI Mater. J. PD MAY-JUN PY 1995 VL 92 IS 3 BP 335 EP 335 PG 1 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA RD841 UT WOS:A1995RD84100017 ER PT J AU KAHN, LF MEYER, KF AF KAHN, LF MEYER, KF TI RECTANGULAR STRESS BLOCK FOR NONRECTANGULAR COMPRESSION ZONE SO ACI STRUCTURAL JOURNAL LA English DT Article DE FLEXURAL STRENGTH; HIGH-STRENGTH CONCRETE; MODULUS OF ELASTICITY; STRAINS; STRESS BLOCK AB Tests of 19 beams made with high-strength concrete showed that use of the current ACI rectangular stress block was conservative for semicircular compression zones, but slightly unconservative for triangular compression zones. Concrete strengths f(c)' were 9630, 12,800, and 14,830 psi (66.4, 88.2, and 102.2 MPa). Eight beams were constructed with a semicircular cross section to model the compression zone found in a circular column under combined axial load and bending, while eleven were constructed with a triangular cross section to model rectangular columns under biaxial bending. The amount of reinforcing was varied to influence the size of the compression zone and location of neutral axis. Each beam was gaged to measure strain in both the concrete and steel. The rectangular stress block may be used to predict the moment strength of sections with nonrectangular compression zones made with high-strength concrete, although it is slightly unconservative for triangular compression zones. C1 US MIL ACAD,DEPT CIVIL ENGN & MECH,W POINT,NY 10996. RP KAHN, LF (reprint author), GEORGIA INST TECHNOL,SCH CIVIL ENGN,ATLANTA,GA 30332, USA. NR 5 TC 6 Z9 6 U1 0 U2 2 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 INTERNATIONAL WAY, COUNTRY CLUB DRIVE, PO BOX 9094, FARMINGTON HILLS, MI 48333-9094 SN 0889-3241 J9 ACI STRUCT J JI ACI Struct. J. PD MAY-JUN PY 1995 VL 92 IS 3 BP 304 EP 310 PG 7 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA RA616 UT WOS:A1995RA61600005 ER PT J AU GOLDHILL, JM SANDERS, KM SJOGREN, R SHEADONOHUE, T AF GOLDHILL, JM SANDERS, KM SJOGREN, R SHEADONOHUE, T TI CHANGES IN ENTERIC NEURAL REGULATION OF SMOOTH-MUSCLE IN A RABBIT MODEL OF SMALL-INTESTINAL INFLAMMATION SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY LA English DT Article DE ILEITIS; INFLAMMATORY BOWEL DISEASE; NITRIC OXIDE; TACHYKININS ID GUINEA-PIG ILEUM; TRICHINELLA-INFECTED RATS; NITRIC-OXIDE; SUBSTANCE-P; MYENTERIC PLEXUS; EXPERIMENTAL COLITIS; LONGITUDINAL MUSCLE; REBOUND EXCITATION; L-ARGININE; INHIBITION AB In vitro electrophysiological studies of ileal circular muscle from rabbits with ricin-induced inflammation tion were performed to investigate whether altered neural control or myogenic activity contributes to previously described changes in in vivo myoelectric activity. Ricin treatment increased mean slow-wave amplitude but not frequency or resting membrane potential. Prolonged electrical field stimulation evoked a hyperpolarization during the stimulus train and a depolarization on cessation of stimulation. In the presence of atropine, the depolarization was larger in ricin-treated tissue than in control tissue, showing that ileitis enhanced noncholinergic excitation. The nitric oxide synthase inhibitor N-nitro-L-arginine methyl ester reduced the hyperpolarization in ricin-treated but not in control tissue, suggesting that inflammation increased nitric oxide-mediated inhibition. Substance P desensitization reduced noncholinergic excitation and mean slow-wave amplitude only in ricin-treated tissue, demonstrating that changes in these parameters during inflammation resulted from increased release of, or sensitivity to, tachykinins. These data suggest that acute ileitis alters tachykinin- and nitric oxide-mediated neurotransmission that may affect the normal pattern of ileal motility and/or sensory reflexes. C1 UNIV NEVADA, SCH MED, DEPT PHYSIOL, RENO, NV 89557 USA. WALTER REED ARMY INST RES, DIV MED, WASHINGTON, DC 20307 USA. RP GOLDHILL, JM (reprint author), UNIFORMED SERV UNIV HLTH SCI, DEPT MED, ROOM A3060, BETHESDA, MD 20814 USA. FU NIDDK NIH HHS [DK-41315] NR 35 TC 26 Z9 26 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0193-1857 J9 AM J PHYSIOL-GASTR L JI Am. J. Physiol.-Gastroint. Liver Physiol. PD MAY PY 1995 VL 268 IS 5 BP G823 EP G830 PG 8 WC Gastroenterology & Hepatology; Physiology SC Gastroenterology & Hepatology; Physiology GA QW835 UT WOS:A1995QW83500013 PM 7762666 ER PT J AU GREEN, MR CHRISTENSEN, KP AF GREEN, MR CHRISTENSEN, KP TI ARTHROSCOPIC BANKART PROCEDURE - 2-YEAR TO 5-YEAR FOLLOW-UP WITH CLINICAL CORRELATION TO SEVERITY OF GLENOID LABRAL LESION SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article AB We report our results using the arthroscopic Bankart technique described by Morgan (transglenoid suture) on 60 consecutive patients with anterior instability. All had detachment of the glenoid labrum at surgery. Forty-seven patients were available for final followup, which ranged from 2 to 5 years. Of these patients, 18 had experienced recurrent dislocation and 3 had experienced episodes of subluxation after surgery, for an overall failure rate of 42%. Partway into the study, we began to correlate severity of glenoid labral lesion with outcome. We classified the labral lesion in 37 patients using stringent criteria at the time of surgery. Followup among these patients averaged 37 months. Of 22 cases of simple detachment of the labrum with no other significant lesion (Type II labrum), there was one failure (4.5%). Of the 15 cases with significant or complete degeneration of the glenoid labrum-inferior glenohumeral ligament complex (Types IV or V labra), 13 failed (87%). Of the patients without recurrent instability, loss of external rotation averaged 1.5 degrees, strength was 5+/5+ in abduction and external rotation. Average postoperative function was 94% of preinjury levels subjectively, and most patients were able to return to previous activities, including throwing and other overhead sports. Our findings indicate that rates of redislocation after this arthroscopic Bankart procedure correlate directly with the degree of glenoid labrum-inferior glenohumeral ligament complex lesion. C1 TRIPLER ARMY MED CTR,DIV ORTHOPAED,HONOLULU,HI. NR 0 TC 71 Z9 73 U1 0 U2 1 PU AMER ORTHOPAEDIC SOC SPORT MED PI WALTHAM PA 230 CALVARY STREET, WALTHAM, MA 02154 SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD MAY-JUN PY 1995 VL 23 IS 3 BP 276 EP 281 DI 10.1177/036354659502300304 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA RA092 UT WOS:A1995RA09200004 PM 7661252 ER PT J AU SMITH, BC ELLIS, GL MEISKINDBLOM, JM WILLIAMS, SB AF SMITH, BC ELLIS, GL MEISKINDBLOM, JM WILLIAMS, SB TI ECTOMESENCHYMAL CHONDROMYXOID TUMOR OF THE ANTERIOR TONGUE - 19 CASES OF A NEW CLINICOPATHOLOGICAL ENTITY SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Article DE MYXOID; CHONDROID; ECTOMESENCHYMAL; NEURAL; MYOEPITHELIAL; TONGUE ID OSSIFYING FIBROMYXOID TUMOR; NERVE SHEATH MYXOMA; SOFT-TISSUE TUMOR; SALIVARY-GLAND TUMORS; PLEOMORPHIC ADENOMAS; ORAL CAVITY; DIFFERENTIAL-DIAGNOSIS; MONOMORPHIC ADENOMA; BENIGN; CHONDROSARCOMA AB We present 19 cases of a previously undescribed myxoid tumor of the anterior tongue. These lesions occurred in nine women and 10 men aged 9 to 78 years (median, 32 years). Most tumors were seen as slow growing, painless nodules in the anterior dorsal tongue. The duration of growth ranged from a few months to 10 years. All tumors were treated by surgical excision, and two recurred. Microscopically, they exhibited a lobular proliferation of ovoid and fusiform cells, which often had multilobated nuclei and occasional foci of atypia, in a chondromyxoid background. Some tumors entrapped muscle or nerve fibers and had a tendency for blunt infiltration of adjacent tissue, The cells were diffusely and intensely immunoreactive for glial fibrillary acidic protein (GFAP) and cytokeratin but were decorated less frequently with antibodies for smooth muscle actin and S-100 protein. Reactivity for epithelial membrane antigen and desmin was not found. We believe these tumors fail to meet established clinicopathologic criteria for any existing myxoid neoplasms of the tongue, including nerve sheath myxoma, myoepithelioma, benign mixed tumor, ossifying fibromyxoid tumor of soft parts, extraskeletal myxoid chondrosarcoma, and glial and chondroid choristomas or heterotopias. Although the histogenesis of this neoplasm is unclear, we suspect that a cell of undifferentiated ectomesenchyme is the progenitor and suggest the descriptive term ectomesenchymal chondromyxoid tumor (ECT) of the anterior tongue be adopted. C1 ARMED FORCES INST PATHOL,DEPT ORAL PATHOL,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,DEPT SOFT TISSUE PATHOL,WASHINGTON,DC 20306. DEPT VET AFFAIRS,SPECIAL REFERENCE LAB PATHOL,WASHINGTON,DC. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,LAB SERV,WASHINGTON,DC 20307. RP SMITH, BC (reprint author), ARMED FORCES INST PATHOL,DEPT OTOLARYNG & ENDOCRINE PATHOL,6825 16TH ST SW,WASHINGTON,DC 20306, USA. NR 49 TC 54 Z9 54 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD MAY PY 1995 VL 19 IS 5 BP 519 EP 530 DI 10.1097/00000478-199505000-00003 PG 12 WC Pathology; Surgery SC Pathology; Surgery GA QU076 UT WOS:A1995QU07600003 PM 7726361 ER PT J AU WU, SJL HAYES, CG DUBOIS, DR WINDHEUSER, MG KANG, YH WATTS, DM SIECKMANN, DG AF WU, SJL HAYES, CG DUBOIS, DR WINDHEUSER, MG KANG, YH WATTS, DM SIECKMANN, DG TI EVALUATION OF THE SEVERE COMBINED IMMUNODEFICIENT (SCID) MOUSE AS AN ANIMAL-MODEL FOR DENGUE VIRAL-INFECTION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VIRUS-INFECTION; MONONUCLEAR PHAGOCYTES; MONOCLONAL-ANTIBODIES; NK CELLS; MICE; BLOOD; INVIVO; ENHANCEMENT; LEUKOCYTES; SYSTEM AB Severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood lymphocytes (hu-PBL) were evaluated as an animal model for demonstrating dengue (DEN) viral infection. Reconstituted mice (hu-PBL-SCID) that demonstrated successful engraftment by the presence of serum titers of human immunoglobulin (Ig) were inoculated intraperitoneally with DEN virus serotype 1 (DEN-1). Serial blood samples were taken postinoculation and assayed for virus in C6/36 cells. The identity of all viral isolates was confirmed by an immunofluorescence antibody assay using DEN-1 monoclonal antibody. A total of six experiments were performed using different procedures of reconstitution and infection, and in three of these experiments, DEN-1 virus was recovered from the hu-PBL-SCID mice. In the first successful experiment, DEN-1 virus was recovered on postinoculation day (PID) 24 from blood, spleen, thymus, and lung tissues of one of eight hu-PBL-SCID mice. A second group of eight hu-PBL-SCID mice were inoculated with human monocytes infected in vitro with DEN-1 virus. Virus was recovered from the blood of mice between PID 15 and 23, and from lung tissue of one of these mice. In a third experiment, seven SCID mice were treated initially with anti-asialo GM1 antibody to eliminate natural killer cells, and then were injected simultaneously with a mixture of hu-PBL and DEN-1 virus. Virus was demonstrated in the blood of one mouse on PID 38, and in another mouse on PID 8, 12, 20, 24, and 36. Virus was recovered from lung tissue of the first mouse on PID 85 and from all tissues tested from the second mouse on PID 50. Tissues from the second mouse also were tested by immunostaining, and DEN viral antigen was detected in liver, spleen, kidney and lune sections; human B cells were detected in spleen and lung tissues, and human T cells were detected in lung and brain. The DEN virus-positive mice from all three experiments had been reconstituted with lymphoid cells from the same human donor. None of the 16 nonreconstituted SCID mice inoculated with DEN-1 virus as controls for these three experiments had detectable virus in any tissues. Attempts to detect evidence of DEN-1 virus infection of hu-PBL-SCID mice in three additional experiments using other human donors were unsuccessful. Data derived from these experiments show that hu-PBL-SCID mice can be infected with DEN-1 virus, but the frequency of infection was low. Further studies need to be conducted to better define and control the factors responsible for susceptibility to DEN virus infection in the hu-PBL-SCID mouse before it will be useful as a laboratory model. C1 WALTER REED ARMY INST RES, DEPT BIOL RES, WASHINGTON, DC USA. USN, MED RES INST, DIV PATHOBIOL, BETHESDA, MD 20889 USA. RP WU, SJL (reprint author), USN, MED RES INST, DEPT INFECT DIS, CODE 4121, 8901 WISCONSIN AVE, BETHESDA, MD 20889 USA. NR 34 TC 49 Z9 53 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 1995 VL 52 IS 5 BP 468 EP 476 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA RB019 UT WOS:A1995RB01900018 PM 7771614 ER PT J AU HELD, TK ADAMCZIK, C TRAUTMANN, M CROSS, AS AF HELD, TK ADAMCZIK, C TRAUTMANN, M CROSS, AS TI EFFECTS OF MICS AND SUB-MICS OF ANTIBIOTICS ON PRODUCTION OF CAPSULAR POLYSACCHARIDE OF KLEBSIELLA-PNEUMONIAE SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ENCAPSULATED STAPHYLOCOCCUS-AUREUS; SURFACE HYDROPHOBICITY; ESCHERICHIA-COLI; CIPROFLOXACIN; IMMUNOGLOBULINS; CEPHALOSPORINS; SUSCEPTIBILITY; PHAGOCYTOSIS; COMPLEMENT; ANTIGENS AB In the present study, we examined whether MICs and sub-MICs of antimicrobial agents belonging to two different classes, ciprofloxacin and ceftazidime, were able to influence the production and release of cell-associated and soluble (extracellular) capsular polysaccharide (CPS), respectively, in a heavily encapsulated strain of Klebsiella pneumoniae (B5055). Using a CPS-specific enzyme-linked immunosorbent assay, we found that the amount of cell-associated CPS increased in a dose dependent manner by more than 10-fold under the influence of the MIC of ceftazidime and by more than 100-fold under the influence of the MIC of ciprofloxacin. The largest amounts of CPS were measured by using the MIC of either antibiotic substance. Electron microscopic studies showed that the diameter of the capsule was significantly increased compared with the diameter for untreated controls. Thus, both antimicrobial agents genuinely stimulated CPS production. C1 FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW CHARLOTTENBURG,HAMATOL & ONKOL ABT,W-1000 BERLIN,GERMANY. UNIV ULM,INST MIKROBIOL,W-7900 ULM,GERMANY. WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC. NR 29 TC 12 Z9 13 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAY PY 1995 VL 39 IS 5 BP 1093 EP 1096 PG 4 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA QW019 UT WOS:A1995QW01900013 PM 7625794 ER PT J AU ZVILICH, M WILLIAMS, JC WAAG, D RILL, WR BELL, P KENDE, M AF ZVILICH, M WILLIAMS, JC WAAG, D RILL, WR BELL, P KENDE, M TI EFFICACY OF COXIELLA-BURNETII AND ITS CHLOROFORM-METHANOL RESIDUE (CMR) FRACTION AGAINST RIFT-VALLEY FEVER VIRUS-INFECTION IN MICE SO ANTIVIRAL RESEARCH LA English DT Article DE ANTIVIRAL SUBSTANCE; RICKETTSIAL EXTRACT; IMMUNOMODULATOR; RVF VIRUS ID PHASE-I; INTERFERON-ALPHA; POLY(ICLC); RIBAVIRIN; IMMUNITY; VACCINE; BETA AB Strains of Coxiella burnetii phase I and II whole cells (WC-I and WC-II) or whole cell fractions were assessed for their potential to induce long-lasting protection in endotoxin-non-responder C3H/HeJ or CD-1 mice against Rift Valley fever (RVF) virus challenge. Among the whole cell fractions, only the chloroform-methanol residue (CMR), administered as a single dose (100 mu g per mouse) 24 h before viral challenge, effectively protected 100% of the mice from RVF virus; the CMR of the Ohio strain of C. burnetii was not protective. Most of the RVF virus-infected mice treated with other C. burnetii cell fractions died, although their times to death varied. Lipopolysaccharide (LPS) associated with CMR preparations used in these studies, did not protect against RVF virus challenge. A single dose of 100 mu g of CMR given 24 h before viral challenge completely eradicated 4-5 logs of RVF virus in the serum, liver, spleen, and central nervous system. Compared to several other immunomodulators, CMR was an equally effective antiviral agent. Efficacy of CMR of both Henzerling and Ohio,strains disappeared or was marginal when treatment was initiated 2-3 days before RVF viral challenge, even when a second or a third dose of CMR was administered after challenge. A single dose of liposome-encapsulated CMR to RVF virus-infected mice extended the range of therapeutic efficacy of this biologically active component of C. burnetii to 4 days before infection. C1 USA,MED RES INST INFECT DIS,DEPT CLIN IMMUNOL,DIV APPL RES,FT DETRICK,MD 21702. USA,MED RES INST INFECT DIS,DEPT PATHOGENESIS & IMMUNOL,DIV BACTERIOL,FT DETRICK,MD 21702. US FDA,CTR BIOL EVALUAT & RES,OFF VACCINE RES & REVIEW,DIV VACCINES & RELATED PROD APPLICAT,ROCKVILLE,MD 20852. NR 32 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD MAY PY 1995 VL 27 IS 1-2 BP 137 EP 149 DI 10.1016/0166-3542(95)00003-5 PG 13 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA RA073 UT WOS:A1995RA07300011 PM 7486951 ER PT J AU YAKIMOV, MM TIMMIS, KN WRAY, V FREDRICKSON, HL AF YAKIMOV, MM TIMMIS, KN WRAY, V FREDRICKSON, HL TI CHARACTERIZATION OF A NEW LIPOPEPTIDE SURFACTANT PRODUCED BY THERMOTOLERANT AND HALOTOLERANT SUBSURFACE BACILLUS-LICHENIFORMIS BAS50 SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE PHOSPHODIESTERASE; FATTY-ACIDS; STRUCTURAL-ANALYSIS; BIOSURFACTANT; SUBTILIS; BIOSYNTHESIS; STRAIN; BACILLUS-LICHENIFORMIS-86; ACYLPEPTIDES; INHIBITORS AB Strain BAS50, isolated from a petroleum reservoir at a depth of 1,500 m and identified as Bacillus licheniformis, grew and produced a lipopeptide surfactant when cultured on a variety of substrates at salinities of up to 13% NaCl. Surfactant production occurred both aerobically and anaerobically and was optimal at 5% NaCl and temperatures between 35 and 45 degrees C. The biosurfactant, termed lichenysin A, was purified and chemically characterized, A tentative structure and composition for the surfactant are described, Lichenysin A is a mixture of lipopeptides, with the major components ranging in size from 1,006 to 1,034 Da. The lipid moiety contains a mixture of 14 linear and branched beta-hydroxy fatty acids ranging in size from C-12 to C-17. There are seven amino acids per molecule, The peptide moiety is composed of the following amino acids: glutamic acid as the N-terminal amino acid, asparagine, valine, leucine, and isoleucine as the C-terminal amino acid, at a ratio of 1.1:1.1:1.0:2.8:1.0, respectively. Purified lichenysin A decreases the surface tension of water from 72 mN/m to 28 mN/m and achieves the critical micelle concentration with as little as 12 mg/liter, characterizing the product as a powerful surface-active agent that compares favorably to others surfactants, The antibacterial activity of lichenysin A has been demonstrated. C1 TECH UNIV CAROLO WILHELMINA BRAUNSCHWEIG,BIOCTR,W-3300 BRAUNSCHWEIG,GERMANY. GBF NATL RES CTR BIOTECHNOL,MOLECT STRUCT RES,D-38124 BRAUNSCHWEIG,GERMANY. USAGE,WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS. RP YAKIMOV, MM (reprint author), GBF NATL RES CTR BIOTECHNOL,DEPT MICROBIOL,DIV MICROBIOL,MICROBIAL ECOL GRP,D-38124 BRAUNSCHWEIG,GERMANY. OI Yakimov, Michail/0000-0003-1418-363X NR 38 TC 232 Z9 253 U1 2 U2 22 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD MAY PY 1995 VL 61 IS 5 BP 1706 EP 1713 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA QW184 UT WOS:A1995QW18400005 PM 7646007 ER PT J AU MOSS, DG BENAROYA, H AF MOSS, DG BENAROYA, H TI A DISCRETE INVERSE VIBRATION PROBLEM WITH PARAMETER UNCERTAINTY SO APPLIED MATHEMATICS AND COMPUTATION LA English DT Article ID EIGENVECTORS; DERIVATIVES; EIGENVALUES AB Inverse vibration problems consider the use of eigenvalue data to calculate the properties of a linear dynamic system. The present study examines the effects of uncertainty in such problems. The type of problem studied is limited to simple spring-mass systems, that is, undamped discrete systems. A procedure is available for finding the values of these spring constants and masses from two sets of eigenvalues, one from the system with one free end, and one from the same system with a more restrictive boundary condition. Expressions are derived for estimating the statistics of these system parameters using the statistics of the eigenvalues. These expressions are based on first-order and second-order perturbation expansions and require the evaluation of partial derivatives of the stiffnesses and masses in terms of the eigenvalues. Results are obtained for several systems which differ in amount of uncertainty, boundary conditions, and number of degrees of freedom. These results are compared to those given by Monte Carlo simulation. The results show excellent agreement for sufficiently small degrees of randomness, as would be expected from using a perturbation method. C1 RUTGERS STATE UNIV,DEPT MECH & AEROSP ENGN,PISCATAWAY,NJ 08855. RP MOSS, DG (reprint author), USA,ARMAMENT RES,CTR DEV & ENGN,PICATINNY ARSENAL,NJ 07806, USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0096-3003 J9 APPL MATH COMPUT JI Appl. Math. Comput. PD MAY PY 1995 VL 69 IS 2-3 BP 313 EP 333 DI 10.1016/0096-3003(94)00140-Y PG 21 WC Mathematics, Applied SC Mathematics GA QV426 UT WOS:A1995QV42600012 ER PT J AU TOCCI, MD BLOEMER, MJ SCALORA, M DOWLING, JP BOWDEN, CM AF TOCCI, MD BLOEMER, MJ SCALORA, M DOWLING, JP BOWDEN, CM TI THIN-FILM NONLINEAR-OPTICAL DIODE SO APPLIED PHYSICS LETTERS LA English DT Article C1 UNIV ALABAMA,DEPT PHYS,HUNTSVILLE,AL 35899. RP TOCCI, MD (reprint author), USA,MISSILE COMMAND,WEAPONS SCI DIRECTORATE,AMSMI,RD,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 15 TC 174 Z9 185 U1 0 U2 9 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 1 PY 1995 VL 66 IS 18 BP 2324 EP 2326 DI 10.1063/1.113970 PG 3 WC Physics, Applied SC Physics GA QV249 UT WOS:A1995QV24900006 ER PT J AU BORRADORI, L CALDWELL, JB BRIGGAMAN, RA BURR, CE GAMMON, WR JAMES, WD YANCEY, KB AF BORRADORI, L CALDWELL, JB BRIGGAMAN, RA BURR, CE GAMMON, WR JAMES, WD YANCEY, KB TI PASSIVE TRANSFER OF AUTOANTIBODIES FROM A PATIENT WITH MUTILATING EPIDERMOLYSIS-BULLOSA ACQUISITA INDUCES SPECIFIC ALTERATIONS IN THE SKIN OF NEONATAL MICE SO ARCHIVES OF DERMATOLOGY LA English DT Article ID CUTANEOUS BASEMENT-MEMBRANE; VII COLLAGEN; IMMUNE-COMPLEXES; CYCLOSPORINE; COMPONENT; ANTIGEN; IMMUNOFLUORESCENCE; IDENTIFICATION; COMPLEMENT; GENE AB Background: Epidermolysis bullosa acquisita is a subepidermal bullous disease characterized by IgG autoantibodies directed against type VII collagen in anchoring fibrils. These autoantibodies are believed to play an important role in the pathogenesis of sub-lamina densa blister formation in this disease. Observations: We describe a patient with epidermolysis bullosa acquisita who has developed mutilating acral involvement with early syndactyly and extensive scarring lesions of the scalp. The patient's serum contains IgG autoantibodies that bind the dermal side of 1-mol/L sodium chloride-separated human skin (at a titer up to 5120), as determined by indirect immunofluorescence microscopy, and type VII collagen, as determined by immunoblot. The severity of this patient's disease and the height of his immune response to type VII collagen prompted us to assess the pathogenicity of his autoantibodies in a murine model. Purified IgG from our patient (or that from a healthy volunteer who served as a control) was administered subcutaneously to BALB/c mice (10 mg/g of body weight) on 2 consecutive days. Light microscopy of normal-appearing skin showed pronounced dermal edema and a dense granulocyte-rich infiltrate in the superficial dermis. Deposits of human IgG, murine C3, and the membrane attack complex of complement were found in the epidermal basement membrane of all experimental mice. Immunogold electron microscopy demonstrated that deposits of human IgG in an experimental subject were localized to anchoring fibrils. Serum samples from mice receiving IgG antibodies from our patient had high titers of circulating antibodies directed against the dermal side of 1-mol/L sodium chloride-separated human skin (titer, 640 to 1280). Light, immunofluorescence, and immunogold electron microscopic studies did not detect such specific alterations in any control mice. Conclusions: Acquired autoimmunity to type VII collagen in patients with epidermolysis bullosa acquisita may result in a clinical phenotype closely resembling that observed in patients with dystrophic epidermolysis bullosa. Passive transfer of purified IgG autoantibodies from a patient with severe epidermolysis bullosa acquisita to BALB/c mice produces histologic and immunopathologic alterations consistent with those seen in patients with this disease. C1 NCI,DERMATOL BRANCH,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. UNIV N CAROLINA,DEPT DERMATOL,CHAPEL HILL,NC 27514. UNIFORMED SERV UNIV HLTH SCI,CTR AUDIOVISUAL,BETHESDA,MD 20814. NR 29 TC 35 Z9 36 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD MAY PY 1995 VL 131 IS 5 BP 590 EP 595 DI 10.1001/archderm.131.5.590 PG 6 WC Dermatology SC Dermatology GA QX868 UT WOS:A1995QX86800012 PM 7741548 ER PT J AU DUNN, CL HARRINGTON, A BENSON, PM SAU, P JAMES, WD AF DUNN, CL HARRINGTON, A BENSON, PM SAU, P JAMES, WD TI MELANOMA OF THE SCALP PRESENTING AS POLIOSIS CIRCUMSCRIPTA SO ARCHIVES OF DERMATOLOGY LA English DT Letter RP DUNN, CL (reprint author), WALTER REED ARMY MED CTR,CLIN 1J,WASHINGTON,DC 20307, USA. NR 5 TC 8 Z9 8 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD MAY PY 1995 VL 131 IS 5 BP 618 EP 619 DI 10.1001/archderm.131.5.618 PG 2 WC Dermatology SC Dermatology GA QX868 UT WOS:A1995QX86800025 PM 7741557 ER PT J AU PRUITT, BA AF PRUITT, BA TI THE INTEGRATION OF CLINICAL CARE AND LABORATORY RESEARCH - A MODEL FOR MEDICAL PROGRESS SO ARCHIVES OF SURGERY LA English DT Article; Proceedings Paper CT 1994 Annual Scientific Session of the Western-Surgical-Association CY NOV 14-16, 1994 CL PALM DESERT, CA SP W SURG ASSOC ID ACUTE GASTRODUODENAL DISEASE; SMOKE-INHALATION INJURY; THERMAL-INJURY; BIOMEDICAL-RESEARCH; HEALTH-CARE; INFECTION; NIH; VENTILATION; SCIENTISTS; SYSTEM RP PRUITT, BA (reprint author), USA,MED CORPS,INST SURG RES,2322 HARNEY RD,FT SAM HOUSTON,TX 78234, USA. NR 83 TC 2 Z9 2 U1 2 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD MAY PY 1995 VL 130 IS 5 BP 461 EP 471 PG 11 WC Surgery SC Surgery GA QX159 UT WOS:A1995QX15900001 PM 7748082 ER PT J AU YOUNG, GD KOPLOVITZ, I AF YOUNG, GD KOPLOVITZ, I TI ACUTE TOXICITY OF CYCLOHEXYLMETHYLPHOSPHONOFLUORIDATE (CMPF) IN RHESUS-MONKEYS - SERUM BIOCHEMICAL AND HEMATOLOGIC CHANGES SO ARCHIVES OF TOXICOLOGY LA English DT Article DE CYCLOHEXYLMETHYLPHOSPHONOFLUORIDATE; RHESUS MONKEY; SERUM; BIOCHEMISTRY; HEMOTOLOGY ID SOMAN; RATS AB Changes in serum biochemical and hematological parameters were studied in 20 male rhesus monkeys following acute poisoning by the organophosphate nerve agent cyclohexylmethylphosphonofluoridate (CMPF or GF). Animals were challenged with 5 x LD50 GF (233 mu g/kg, IM) following pretreatment with pyridostigmine (0.3-0.7 mg/kg per 24 h) and treated with atropine (0.4 mg/kg, IM) and either 2-PAM (25.7 mg/kg, IM) or HI6 (37.8 mg/kg, IM) at the onset of clinical signs or at 1 min after exposure. Muscle fasciculations, tremors, or convulsions occurred in 19 of 20 animals. Serum biochemical and hematologic parameters were analyzed 2 days and 7 days after exposure and compared to pre-exposure baseline values. Significant increases in creatine kinase (CK), lactate dehydrogenase (LD), aspartate transaminase (AST), alanine transaminase (ALT) and potassium ion (Kf), associated with damage to striated muscle and metabolic acidosis, occurred in both oxime-treated groups 2 days after exposure, Total protein, albumin, red blood cell (RBC) count, hemoglobin concentration (Hb) and hematocrit (Hct), were decreased in both oxime-treated groups at 7 days. The results demonstrate that animals exposed to a single high dose of GF and treated with standard therapy exhibit changes in serum biochemical and hematological indices directly and indirectly associated with their clinical presentations. RP YOUNG, GD (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 14 TC 12 Z9 12 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-5761 J9 ARCH TOXICOL JI Arch. Toxicol. PD MAY PY 1995 VL 69 IS 6 BP 379 EP 383 DI 10.1007/s002040050187 PG 5 WC Toxicology SC Toxicology GA RB009 UT WOS:A1995RB00900004 PM 7495375 ER PT J AU DESHPANDE, SS SMITH, CD FILBERT, MG AF DESHPANDE, SS SMITH, CD FILBERT, MG TI ASSESSMENT OF PRIMARY NEURONAL CULTURE AS A MODEL FOR SOMAN-INDUCED NEUROTOXICITY AND EFFECTIVENESS OF MEMANTINE AS A NEUROPROTECTIVE DRUG SO ARCHIVES OF TOXICOLOGY LA English DT Article DE MEMANTINE PRETREATMENT; SOMAN NEUROTOXICITY; GLUTAMATE EXCITOTOXICITY; HIPPOCAMPAL NEURONS; NEURONAL LOSS ID METHYL-D-ASPARTATE; CORTICAL CELL-CULTURE; HIPPOCAMPAL-NEURONS; INDUCED SEIZURES; GLUTAMATE; RAT; NEUROPATHOLOGY; ACETYLCHOLINE; CONVULSIONS; PROTECTS AB An in vitro mammalian model neuronal system to evaluate the intrinsic toxicity of soman and other neurotoxicants as well as the efficacy of potential countermeasures was investigated. The link between soman toxicity, glutamate hyperactivity and neuronal death in the central nervous system was investigated in primary dissociated cell cultures from rat hippocampus and cerebral neocortex. Exposure of cortical or hippocampal neurons to glutamate for 30 min produced neuronal death in almost 80% of the cells examined at 24h. Hippocampal neurons exposed to soman for 15-120 min at 0.1 mu M concentration caused almost complete inhibition ( greater than or equal to 90%) of acetylcholinesterase but failed to show any evidence of effects on cell viability, indicating a lack of direct cytotoxicity by this agent. Acetylcholine (ACh, 0.1mM), alone or in combination with soman, did not potentiate glutamate toxicity in hippocampal neurons. Memantine, a drug used for the therapy of Parkinson's disease, spasticity and other brain disorders, significantly protected hippocampal and cortical neurons in culture against glutamate and N-methyl-D-aspartate (NMDA) excitotoxicity. In rats a single dose of memantine (18 mg/kg) administered 1 h prior to a s.c. injection of a 0.9 LD(50) dose of soman reduced the severity of convulsions and increased survival. Survival, however, was accompanied by neuronal loss in the frontal cortex, piriform cortex and hippocampus. RP DESHPANDE, SS (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 33 TC 30 Z9 31 U1 0 U2 2 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-5761 J9 ARCH TOXICOL JI Arch. Toxicol. PD MAY PY 1995 VL 69 IS 6 BP 384 EP 390 DI 10.1007/s002040050188 PG 7 WC Toxicology SC Toxicology GA RB009 UT WOS:A1995RB00900005 PM 7495376 ER PT J AU SFIKAKIS, PP ZOGRAFOU, A VIGLIS, V INIOTAKITHEODORAKI, A PISKONTAKI, I TSOKOS, GC SFIKAKIS, P CHOREMIPAPADOPOULOU, H AF SFIKAKIS, PP ZOGRAFOU, A VIGLIS, V INIOTAKITHEODORAKI, A PISKONTAKI, I TSOKOS, GC SFIKAKIS, P CHOREMIPAPADOPOULOU, H TI CD28 EXPRESSION ON T-CELL SUBSETS IN-VIVO AND CD28-MEDIATED T-CELL RESPONSE IN-VITRO IN PATIENTS WITH RHEUMATOID-ARTHRITIS SO ARTHRITIS AND RHEUMATISM LA English DT Article ID LYMPHOCYTES-T; COSTIMULATION AB Objective. In view of the critical importance of the CD28-CD80 (B7/BB1) costimulatory pathway in antigen-specific T cell activation and clonal expansion, we examined CD28 surface molecule expression in vivo, and T cell receptor/CD3-mediated and B7/BB1-costimulated T cell proliferation in vitro, in rheumatoid arthritis (RA), Methods. Two-color immunofluorescence analyses of peripheral blood and synovial fluid-derived T cells, as well as H-3-thymidine incorporation assays, were performed, Results. In the peripheral blood of 31 patients with active, untreated RA, a mean of 91% (range 48-100%) of CD4+ and 46% (range 13-82%) of CD8+ T cell subsets were CD28+ which was not significantly lower than normal, Although an overall decrease in the number of T cells was not observed, the numbers of CD28+CD8+ T cells were significantly lower in RA patients (mean 233/mu l, versus 292/mu l in controls), and this decrease was more pronounced in patients with severe disease (mean 172/mu l). CD28 expression on peripheral CD8+ T cells in RA patients, but not in healthy individuals, correlated inversely with T cell activation as assessed by HLA-DR antigen expression, In contrast to the peripheral blood, RA synovial fluid T cells were almost exclusively CD28+, suggesting that migration of CD28+CD8+ T cells to active sites of inflammation may occur, In vitro proliferative responses of peripheral blood T cells to B7/BB1 costimulation in the presence of mitogenic doses of anti-CDS monoclonal antibody were identical in patients with RA and healthy individuals. Conclusion. Functionally intact CD28+ T cells may contribute to the abnormal immunoregulation and joint inflammation in RA. C1 UNIV ATHENS,SCH MED,GR-11527 ATHENS,GREECE. WALTER REED ARMY MED CTR,WASHINGTON,DC. RP SFIKAKIS, PP (reprint author), LAIKON GEN HOSP,DEPT PROPAEDEUT MED,17 AG THOMA ST,GR-11527 ATHENS,GREECE. NR 18 TC 27 Z9 28 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQUARE, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD MAY PY 1995 VL 38 IS 5 BP 649 EP 654 DI 10.1002/art.1780380512 PG 6 WC Rheumatology SC Rheumatology GA QX392 UT WOS:A1995QX39200011 PM 7538295 ER PT J AU CLAFFEY, KJ JONES, KF RYERSON, CC AF CLAFFEY, KJ JONES, KF RYERSON, CC TI USE AND CALIBRATION OF ROSEMOUNT ICE DETECTORS FOR METEOROLOGICAL RESEARCH SO ATMOSPHERIC RESEARCH LA English DT Article; Proceedings Paper CT 6th Workshop on Atmospheric Icing of Structures CY 1993 CL BUDAPEST, HUNGARY AB Vibrating probe ice detectors made by Rosemount Inc., are used by many researchers for measuring atmospheric icing rates and cloud liquid water contents. The vibration frequency of the probe decreases as ice accretes on it, until the probe is deiced at a factory-set frequency. Rosemount ice detectors are favored because they are readily available, easy to install and simple to operate. They are designed to be used as warning systems for incipient aircraft and antenna icing, and not as precisely calibrated scientific instruments. Calibration cannot be user adjusted, but it can be measured and must be periodically checked if the ice detector is to be used in scientific studies. We briefly describe three models of Rosemount ice detectors that CRREL has used. Methods for collecting and processing the data from these ice detectors are described and evaluated. Procedures developed at CRREL for calibrating Rosemount detectors against a rotating multicylinder in natural icing conditions are presented. Results of calibrations of two model 872B12 Rosemount ice detectors with the rotating multicylinder are presented and discussed. Use of the ice detector record to calculate cloud liquid water content is described. RP CLAFFEY, KJ (reprint author), USA,COLD REG RES & ENGN LAB,SNOW & ICE BRANCH,72 LYME RD,HANOVER,NH 03755, USA. NR 7 TC 10 Z9 12 U1 0 U2 1 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0169-8095 J9 ATMOS RES JI Atmos. Res. PD MAY PY 1995 VL 36 IS 3-4 BP 277 EP 286 DI 10.1016/0169-8095(94)00042-C PG 10 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA RC502 UT WOS:A1995RC50200010 ER PT J AU RYERSON, CC AF RYERSON, CC TI SUPERSTRUCTURE SPRAY AND ICE ACCRETION ON A LARGE US-COAST-GUARD CUTTER SO ATMOSPHERIC RESEARCH LA English DT Article; Proceedings Paper CT 6th Workshop on Atmospheric Icing of Structures CY 1993 CL BUDAPEST, HUNGARY AB Superstructure spray flux and ice accretion were measured on a 115-m Coast Guard cutter in the North Pacific Ocean and the Bering Sea during February and March 1990. This was the first such measurement cruise on a large ship; all previous measurements were on trawlers and patrol boats. Spray event duration averaged 2.73 s, somewhat longer than events measured on a 35-m Soviet trawler. The drop number concentration of most spray clouds was high, ranging from 2.0 x 10(5) to 3.0 x 10(5) drops m(-3). Spray cloud drop sizes ranged from 14 to 7700 mu m, with a geometric median of 234 mu m. Spray cloud liquid water contents had a very large range with a mean of 64.1 g . m(-3). Ice accretion rates were low, but sufficient for observing greater ice thicknesses on decks than on bulkheads. The ice accretion process was also found to be extremely dynamic, alternately accreting and ablating several times before reaching maximum thickness. No simple relationships were found between time-series of ice thickness during two icing events and controlling environmental parameters. RP RYERSON, CC (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 33 TC 9 Z9 9 U1 0 U2 2 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0169-8095 J9 ATMOS RES JI Atmos. Res. PD MAY PY 1995 VL 36 IS 3-4 BP 321 EP 337 DI 10.1016/0169-8095(94)00045-F PG 17 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA RC502 UT WOS:A1995RC50200014 ER PT J AU DAVIS, HQ KAMIMORI, GH KULESH, DA MEHM, WJ ANDERSON, LH ELSAYED, AM BURGE, JR BALKIN, TJ AF DAVIS, HQ KAMIMORI, GH KULESH, DA MEHM, WJ ANDERSON, LH ELSAYED, AM BURGE, JR BALKIN, TJ TI VISUAL PERFORMANCE WITH THE AVIATOR NIGHT-VISION IMAGING-SYSTEM (ANVIS) AT A SIMULATED ALTITUDE OF 4300 METERS SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID DESIGN AB This study determined if visual performance with Aviator Night Vision Imaging System (ANVIS) was degraded by the degree of hypoxia experienced at the maximum flight altitude currently authorized (U.S. Army regulations) without supplemental oxygen, Visual acuity and contrast sensitivity with ANVIS were tested under simulated starlight and full moonlight illumination in a hypobaric chamber: at ground level (93 m), 5 min and 30 min after ascent to 4300 m, and 10 min after return to ground level, Visual acuity was significantly (p < 0.05) de graded by a small amount (0.05 log minimal angle resolvable) after 30 min at 4300 m. contrast sensitivity was not significantly degraded at any time. No significant difference between males (n = 11) and females (n = 6) on any measure of visual performance was detected, Females did have a significantly lower percent oxygen saturation of hemoglobin compared with males at altitude (72% versus 80% after 30 min). The results suggests that visual acuity with ANVIS is degraded slightly after 30 min of exposure to 4300 mr although lass than what would be expected with unaided night vision under these conditions. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BIOSTAT,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DIV ALTITUDE & HYPERBAR PHYSIOL,WASHINGTON,DC 20306. RP DAVIS, HQ (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BEHAV BIOL,WASHINGTON,DC 20307, USA. NR 20 TC 8 Z9 8 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 1995 VL 66 IS 5 BP 430 EP 434 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA QX391 UT WOS:A1995QX39100006 PM 7619036 ER PT J AU MUKHERJEE, S SINHA, D BATES, PR SCHEFFER, R CORRENTI, EE MAHADIK, SP MAHADIK, J AF MUKHERJEE, S SINHA, D BATES, PR SCHEFFER, R CORRENTI, EE MAHADIK, SP MAHADIK, J TI ABNORMAL GROWTH OF CULTURED SKIN FIBROBLASTS FROM PSYCHOTIC-PATIENTS SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 MED COLL GEORGIA,AUGUSTA,GA 30912. DEPT VET AFFAIRS MED CTR,AUGUSTA,GA. DDE ARMY MED CTR,FT GORDON,GA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiat. PD MAY 1 PY 1995 VL 37 IS 9 BP 626 EP 627 DI 10.1016/0006-3223(95)94533-3 PG 2 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA QX037 UT WOS:A1995QX03700124 ER PT J AU MUKHERJEE, S CRAPANZANO, K CASANOVA, MF SCHEFFER, R CORRENTI, EE BATES, PR MAHADIK, SP MAHADIK, J AF MUKHERJEE, S CRAPANZANO, K CASANOVA, MF SCHEFFER, R CORRENTI, EE BATES, PR MAHADIK, SP MAHADIK, J TI MITOGENIC RESPONSE TO BFGF AND CEREBRAL VOLUME IN PSYCHOTIC-PATIENTS SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 MED COLL GEORGIA,AUGUSTA,GA 30912. DVAMC,AUGUSTA,GA 30912. DDE ARMY MED CTR,FT GORDON,GA. GRIFFITH UNIV,BRISBANE,QLD 4111,AUSTRALIA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiat. PD MAY 1 PY 1995 VL 37 IS 9 BP 681 EP 681 DI 10.1016/0006-3223(95)94726-D PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA QX037 UT WOS:A1995QX03700317 ER PT J AU SCHEFFER, R DIAMOND, BI CORRENTI, EE BORISON, RL MAHADIK, SP MUKHERJEE, S AF SCHEFFER, R DIAMOND, BI CORRENTI, EE BORISON, RL MAHADIK, SP MUKHERJEE, S TI PLASMA-LIPID PEROXIDATION AND HVA IN FIRST EPISODE PSYCHOSIS SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA. MED COLL GEORGIA,AUGUSTA,GA 30912. DVAMC,AUGUSTA,GA. NR 0 TC 5 Z9 5 U1 0 U2 2 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiat. PD MAY 1 PY 1995 VL 37 IS 9 BP 681 EP 681 DI 10.1016/0006-3223(95)94727-E PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA QX037 UT WOS:A1995QX03700318 ER PT J AU SCHEFFER, R MAHADIK, SP CORRENTI, EE MCCLURE, M MUKHERJEE, S AF SCHEFFER, R MAHADIK, SP CORRENTI, EE MCCLURE, M MUKHERJEE, S TI MEMBRANE LIPID-PEROXIDATION AND NEUROLOGICAL SIGNS IN FIRST EPISODE PSYCHOSIS SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA. MED COLL GEORGIA,AUGUSTA,GA 30912. DVAMC,AUGUSTA,GA. NR 0 TC 5 Z9 5 U1 0 U2 2 PU ELSEVIER SCIENCE PUBL CO INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiat. PD MAY 1 PY 1995 VL 37 IS 9 BP 681 EP 681 DI 10.1016/0006-3223(95)94727-E PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA QX037 UT WOS:A1995QX03700319 ER PT J AU CALDWELL, J AF CALDWELL, J TI ASSESSING THE IMPACT OF STRESSORS ON PERFORMANCE - OBSERVATIONS ON LEVELS OF ANALYSES SO BIOLOGICAL PSYCHOLOGY LA English DT Article DE PHYSIOLOGICAL ASSESSMENTS; PERFORMANCE ASSESSMENTS; COGNITIVE ASSESSMENTS; FLIGHT EVALUATION; ATROPINE SULFATE; ANTIHISTAMINES; SLEEP DEPRIVATION AB Applied researchers often are required to rely on limited laboratory studies to estimate the effects of various stressors on actual job performance. It can be difficult to select measures which lend themselves to implementation in laboratory settings while also providing sufficient capability to predict complex 'real-world' performance. Studies which employ simulations of operationally-relevant tasks and those which include the administration of basic cognitive tests are favored by many applications-oriented researchers. This is despite the fact that such a testing approach may limit sensitivity due to the requirements for extensive practice on these tasks in order to obtain stable results. Studies which use physiological assessments appear to be less readily accepted by applied researchers because of the difficulties in drawing a direct link between physiological indexes and operational performance. However, there are arguments to be made for the inclusion of physiological evaluations with the more traditional, performance-based measures. Data from three studies are cited here to support the value of using a multifaceted approach to the study of operationally-relevant stressors. Although these studies were not conducted to systematically investigate the relative merits of performance, cognitive, and physiological assessments, they do serve to highlight the fact that inclusion of all three types of tests tend to maximize the validity, interpretability, and sensitivity of applied research. RP CALDWELL, J (reprint author), USA,AEROMED RES LAB,FT RUCKER,AL 36362, USA. NR 11 TC 10 Z9 12 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0301-0511 J9 BIOL PSYCHOL JI Biol. Psychol. PD MAY PY 1995 VL 40 IS 1-2 BP 197 EP 208 DI 10.1016/0301-0511(95)05115-5 PG 12 WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology, Experimental SC Psychology; Behavioral Sciences GA RB501 UT WOS:A1995RB50100014 PM 7647181 ER PT J AU PAYNE, BS LEI, J MILLER, AC HUBERTZ, ED AF PAYNE, BS LEI, J MILLER, AC HUBERTZ, ED TI ADAPTIVE VARIATION IN PALP AND GILL SIZE OF THE ZEBRA MUSSEL (DREISSENA-POLYMORPHA) AND ASIAN CLAM (CORBICULA-FLUMINEA) SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES LA English DT Article ID SUSPENSION-FEEDING BIVALVES; MYTILUS-EDULIS; PARTICLE SELECTION; UNITED-STATES; GREAT-LAKES AB Significant interpopulation differences occur in palp to gill area ratios of two nonindigenous species of freshwater bivalves in North America, Dreissena polymorpha and Corbicula fluminea. Larger palps (both species) and smaller gills (C. fluminea) occur in individuals from habitats characterized by a relatively high suspended solids concentration. The extremely brief evolutionary history of both species in North America is strong evidence that these differences in palp to gill area ratios are ecophenotypic. C1 UNIV SO MISSISSIPPI,DEPT BIOL SCI,HATTIESBURG,MS 39406. RP PAYNE, BS (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 30 TC 29 Z9 29 U1 1 U2 9 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0706-652X J9 CAN J FISH AQUAT SCI JI Can. J. Fish. Aquat. Sci. PD MAY PY 1995 VL 52 IS 5 BP 1130 EP 1134 DI 10.1139/f95-109 PG 5 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA RX749 UT WOS:A1995RX74900022 ER PT J AU BLUMENTHAL, RS CARTER, AJ RESAR, JR COOMBS, V GLOTH, ST DALAL, J BRINKER, JA AF BLUMENTHAL, RS CARTER, AJ RESAR, JR COOMBS, V GLOTH, ST DALAL, J BRINKER, JA TI COMPARISON OF BEDSIDE AND HOSPITAL LABORATORY COAGULATION STUDIES DURING AND AFTER CORONARY INTERVENTION SO CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS LA English DT Article DE COAGULATION; HEPARIN; PTCA ID PARTIAL THROMBOPLASTIN TIME; ACTIVATED CLOTTING TIME; HEPARIN-THERAPY; VASCULAR COMPLICATIONS; ANGIOPLASTY; ANTICOAGULATION; RANGE AB The activated clotting time is routinely used to monitor anticoagulation during coronary intervention, whereas the hospital laboratory APTT guides pre- and postprocedure heparin therapy, An optimal coagulation test far patients undergoing percutaneous revascularization would provide a rapid and accurate assessment of anticoagulation throughout a broad range of heparin therapy, We studied the relationships of the bedside whole blood APTT, ACT, and the laboratory APTT in 166 patients undergoing coronary intervation. The whole blood APTT correlated closely with the laboratory APTT (range 18-80 sec) (r = .75), whereas the ACT and laboratory APTT had only a fair correlation(r = .42). Also, the whole blood APTT demonstrated a strong correlation with the ACT throughout the range of heparin therapy for intervention (r = .81), The diagnostic accuracy of the whole blood APTT, based on the receiver operating characteristic curve, was significantly better than that for the ACT in determining the anticoagulation status. The whole blood APTT obtained by bedside monitoring provides a rapid and accurate assessment of anticoagulation throughout the range of heparin dosing associated with coronary intervention, In situations in which an adequate assessment of residual anticoagulation is necessary, the whole blood APTT is superior to the ACT and probably should be the method of choice. (C) 1995 Wiley-Liss, Inc. C1 JOHNS HOPKINS UNIV,BALTIMORE,MD 21218. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 33 TC 10 Z9 11 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-6569 J9 CATHETER CARDIO DIAG JI Catheter. Cardiovasc. Diagn. PD MAY PY 1995 VL 35 IS 1 BP 9 EP 17 DI 10.1002/ccd.1810350104 PG 9 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA QV705 UT WOS:A1995QV70500003 PM 7614548 ER PT J AU YANG, YC AF YANG, YC TI CHEMICAL-REACTIONS FOR NEUTRALIZING CHEMICAL WARFARE AGENTS SO CHEMISTRY & INDUSTRY LA English DT Article ID HYDROLYSIS RP YANG, YC (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010, USA. NR 21 TC 68 Z9 68 U1 0 U2 9 PU SOC CHEMICAL INDUSTRY PI LONDON PA 14 BELGRAVE SQUARE, LONDON, ENGLAND SW1X 8PS SN 0009-3068 J9 CHEM IND-LONDON JI Chem. Ind. PD MAY 1 PY 1995 IS 9 BP 334 EP 337 PG 4 WC Chemistry, Applied SC Chemistry GA QV692 UT WOS:A1995QV69200007 ER PT J AU HNATIUK, MOW DILLARD, LTA TORRINGTON, CKG AF HNATIUK, MOW DILLARD, LTA TORRINGTON, CKG TI ADHERENCE TO ESTABLISHED GUIDELINES FOR PREOPERATIVE PULMONARY-FUNCTION TESTING SO CHEST LA English DT Article DE RESPIRATORY FUNCTION TEST, GUIDELINES; SURGERY, PREOPERATIVE CARE ID STANDARDIZATION; SPIROMETRY AB Guidelines for ordering preoperative spirometry have been proposed by GM Tisi (1979) and more recently by the American College of Physicians (ACP). Requests for preoperative spirometries represent a significant portion of all requests for screening spirometry at our institution and utilize significant man-hours of technician time. We determined the percentage of these requests that did not meet the ACP guidelines and characterized why these requests were being generated. We sampled 441 screening spirometries performed by the Waiter Reed Pulmonary Function Laboratory over a 4-week period. One hundred thirty-eight (31%) of these were done preoperatively and complete data were available in 135 cases. Patients in the analyzed group had a mean age of 59 years (+/- 14) years), ranging from 20 to 84 years of age. Fifty-two (39% requests did not meet ACP guidelines. Most of these requests were associated with either normal spirometry (n = 34) or only mild spirometric abnormalities (n = 14). Spirometry revealed severe obstruction in only one case when the request was not indicated. No cases of moderate obstruction, severe restrictive pattern, or possible upper airway obstruction were found in the group of requests in which spirometry was not indicated. Of the requests that did not meet ACP guidelines, 21 met Tisi's broader guidelines. Most of these requests were found exclusively in patients older than 70 years of age (n = 13) and the morbidly obese (n = 4). Of the 31 studies that did not meet either set of guidelines, 25 occurred in asymptomatic, current, or prior smokers. In conclusion, during a 4-week study period at our institution, 39% of preoperative spirometry requests did not meet ACP guidelines, Most of the patients had been referred because of age greater than 70 years, morbid obesity, and a current/prior history of smoking. However, the literature does not support obtaining preoperative spirometry in such patients except for those undergoing only lung resection. We recommend stricter adherence to the ACP guidelines as a means of decreasing the number and cost of unnecessary spirometries being performed. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP HNATIUK, MOW (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 16 TC 4 Z9 4 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD MAY PY 1995 VL 107 IS 5 BP 1294 EP 1297 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA QY146 UT WOS:A1995QY14600023 ER PT J AU ARGYROS, MGJ TORRINGTON, KG AF ARGYROS, MGJ TORRINGTON, KG TI FIBEROPTIC BRONCHOSCOPY IN THE EVALUATION OF NEWLY-DIAGNOSED ESOPHAGEAL-CARCINOMA SO CHEST LA English DT Article DE BRONCHOSCOPY; CARCINOMA; ESOPHAGUS ID TRACHEOBRONCHIAL INVOLVEMENT; AUTOPSY FINDINGS AB To determine the diagnostic utility of fiberoptic bronchoscopy (FB) in the evaluation of patients with newly diagnosed esophageal carcinoma (EC) and whether FB findings impact therapy and survival, we retrospectively reviewed 2,832 FB records (1984 through 1992). Twenty-two cases were identified in which FB was performed to evaluate pulmonary involvement in patients with newly diagnosed EC. Two cases were eliminated due to data unavailability, Seventeen of 20 patients had no pulmonary symtoms and most of them (15/17) had normal chest radiographs, All three patients with pulmonary symptoms (cough, hemoptysis, dyspnea) had significant radiographic abnormalities, In the asymptomatic group, FB findings were normal in nine, showed extrinsic compression of the trachea and/or bronchi in seven, and demonstrated a submcosal tumor nodule in one, The pathologic diagnosis of malignant airway involvement was not made in any asymptomatic patient, In the three symptomatic patients, extensive endobronchial abnormalities were present, Therapy with surgery, radiation, and/or chemotherapy did not differ among patients with extrinsic compression compared to patients with normal FB, Average survival in the patients with normal endobronchial anatomy was 20.5 months, in the group with extrinsic compression 12.2 months, and in the group with marked endobronchial abnormalities, less than 1 month, Statistical analysis of our findings suggest that FB is a low-yield procedure in the evaluation of patients with EC unless pulmonary symptoms of cough and/or hemoptysis or chest radiographic abnormalities are present. C1 WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SECT,WASHINGTON,DC 20307. NR 6 TC 6 Z9 6 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD MAY PY 1995 VL 107 IS 5 BP 1447 EP 1449 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA QY146 UT WOS:A1995QY14600050 ER PT J AU KELLY, DJ CHAN, CT PAXTON, H THOMPSON, K HOWARD, R DASCH, GA AF KELLY, DJ CHAN, CT PAXTON, H THOMPSON, K HOWARD, R DASCH, GA TI COMPARATIVE-EVALUATION OF A COMMERCIAL ENZYME-IMMUNOASSAY FOR THE DETECTION OF HUMAN-ANTIBODY TO RICKETTSIA-TYPHI SO CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY LA English DT Article ID MICROIMMUNOFLUORESCENCE TEST; SPOTTED-FEVER; DIAGNOSIS; INFECTION AB A commercial enzyme immunoassay kit called the Dip-S-Ticks (DS) for the detection of total immunoglobulin (Ig) G and IgM human antibodies to Rickettsia typhi was evaluated. In tests with 340 serum samples from patients with diagnosed cases of rickettsial diseases, patients suffering from other febrile illnesses, and normal subjects, the DS compared favorably with the standard indirect fluorescent-antibody (IFA) test. At IFA cutoff titers of greater than or equal to 1:64 and greater than or equal to 1:128, the DS showed sensitivities of 88.2 and 91.4% and specificities of 91.8 and 87.7%, respectively. The DS test correlated significantly with both the IFA IgG (r = 0.84, P < 0.0005) and IgM (r 0.63, P < 0.0005) titers. Only 80% of IgG and 82% of IgM IFA readings determined by two technicians were within one dilution, while the DS was more reliable, with 100% within one dot. The rapidity, reliability, and simplicity of the DS suggest that it is a suitable test for use in clinical laboratories unable to perform the IFA test. C1 NATL NAVAL MED CTR, RICKETTSIAL DIS PROGRAM, BETHESDA, MD 20889 USA. INTEGRATED DIAGNOST, BALTIMORE, MD 21227 USA. WALTER REED ARMY MED CTR, DEPT CLIN INVEST, WASHINGTON, DC 20307 USA. RP KELLY, DJ (reprint author), WALTER REED ARMY MED CTR, DEPT CLIN INVEST, WASHINGTON, DC 20307 USA. NR 23 TC 17 Z9 17 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 1071-412X J9 CLIN DIAGN LAB IMMUN JI Clin. Diagn. Lab. Immunol. PD MAY PY 1995 VL 2 IS 3 BP 356 EP 360 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA QW749 UT WOS:A1995QW74900019 PM 7664182 ER PT J AU NAGY, EV MORRIS, JC BURCH, HB BHATIA, S SALATA, K BURMAN, KD AF NAGY, EV MORRIS, JC BURCH, HB BHATIA, S SALATA, K BURMAN, KD TI THYROTROPIN RECEPTOR T-CELL EPITOPES IN AUTOIMMUNE THYROID-DISEASE SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Article ID HUMAN TSH RECEPTOR; GRAVES-DISEASE; RECOGNITION SITES; EXPRESSION; IDENTIFICATION; PEPTIDES; CLONING; BINDING; PROTEIN; ANTIGEN AB The human TSH receptor represents the primary target of thyroid-stimulating immunoglobulins responsible for the hyperthyroidism of Graves' disease. In the present series of investigations, the distribution of T cell epitopes has been mapped using synthetic peptides spanning the entire extracellular region of the human TSH receptor, in vitro proliferative responses of the mononuclear cells were measured using flow cytometric analysis of bromodeoxyuridine incorporation into nuclei, In 8 of 11 samples from patients with Graves' disease, at least one (and up to 9) regions of the human TSH receptor induced proliferation, with the mean stimulation index being 39.8 +/- 47.3. No single universal stimulatory peptide was identified, In contrast, stimulation was not observed in three control subjects, while one control subject showed minimal stimulation (index of 5.7) to peptides encompassing a limited area (amino acids 31-65). The immunodominant epitope of patients with recent-onset Graves' disease was localized between amino acids 271 and 365, whereas the immunodominant epitope of patients with disease duration greater than I year localized between amino acids 91 and 215. We conclude that the bromodeoxyuridine incorporation method is a useful and important tool for detecting antigen-induced iymphocyte proliferation. The TSH receptor-specific T cells from different Graves' disease patients recognize variable distinct sites within the extracellular region of the TSH receptor, and the immunodominant epitope apparently shifts toward the N-terminus of the receptor protein during the course of treated Graves' disease. (C) 1995 Academic Press, Inc. C1 WALTER REED ARMY MED CTR,ENDOCRINE METAB SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,KYLE METAB UNIT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. MAYO CLIN & MAYO FDN,SCH MED,DEPT INTERNAL MED,ROCHESTER,MN 55905. FU FIC NIH HHS [1 FO5 TW04412]; NIDDK NIH HHS [DK42008] NR 25 TC 12 Z9 12 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD MAY PY 1995 VL 75 IS 2 BP 117 EP 124 DI 10.1006/clin.1995.1060 PG 8 WC Immunology; Pathology SC Immunology; Pathology GA QT379 UT WOS:A1995QT37900003 PM 7535671 ER PT J AU WATTERS, MR AF WATTERS, MR TI ORGANIC NEUROTOXINS IN SEAFOODS SO CLINICAL NEUROLOGY AND NEUROSURGERY LA English DT Review DE ORGANIC NEUROTOXIN; MICROORGANISMS; SEAFOOD ID DOMOIC ACID; FISH; CIGUATERA; TETRODOTOXIN; MUSSELS; TOXIN; MANNITOL AB Toxins formed by organic micro-organisms may accumulate within certain tissues of predacious sea animals, which may serve as a source of seafood poisoning for the higher food chain. Such toxins are distinct from inorganic chemicals or infectious agents which may have contaminated the seafoods. Distinct clinical syndromes have emerged, and the individual toxins have been identified. Clinical manifestations of each begin with a gastrointestinal prodrome and headache, followed by sensorimotor deficits. Bulbar and cognitive changes are associated with the more lethal tetrodotoxin, saxitoxin, and domoic acid toxin. Tetrodotoxin and saxitoxin block sodium channels, while ciguatoxin opens them. Domoic acid stimulates excitatory amino acids at the NMDA receptors. RP WATTERS, MR (reprint author), UNIV HAWAII,TRIPLER ARMY MED CTR,NEUROL SERV,HONOLULU,HI 96859, USA. NR 34 TC 23 Z9 28 U1 2 U2 3 PU VAN GORCUM CO BV PI ASSEN PA PO BOX 43, 9400 AA ASSEN, NETHERLANDS SN 0303-8467 J9 CLIN NEUROL NEUROSUR JI Clin. Neurol. Neurosurg. PD MAY PY 1995 VL 97 IS 2 BP 119 EP 124 DI 10.1016/0303-8467(95)00015-C PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA QZ368 UT WOS:A1995QZ36800001 PM 7656483 ER PT J AU KOVACS, A GOW, AJ MOREY, RM AF KOVACS, A GOW, AJ MOREY, RM TI THE IN-SITU DIELECTRIC-CONSTANT OF POLAR FIRN REVISITED SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article ID ICE; FREQUENCIES; SNOW AB The success in using VHF and UHF frequency systems for sounding polar ice sheets has been tempered by an uncertainty in the in-situ dielectric constant which controls the effective velocity of an electromagnetic wave propagating in an air-ice mixture. An empirical equation for determining the relative real dielectric constant epsilon(r)' vs. density (specific gravity rho) of firn or ice was proposed in 1969 by Robin et al. where epsilon'(r) = (1+0.851 rho)2. However, this expression has met with uncertainty because wide-angle radar refraction sounding techniques have produced dielectric constant values that are lower than Robin's equation predicts. This paper discusses radar soundings made on the McMurdo Ice Shelf, Antarctica, and compares the resulting dielectric constant determinations with Robin's equation, laboratory measurements on firn and ice and other expressions given in the literature for determining epsilon'(r) vs. the specific gravity of dry firn and ice. Our findings indicate that the form of Robin's equation is valid. Our analysis also indicates the expression could be slightly improved to read epsilon'(r) = (1 + 0.845 rho)2. Reasons are suggested as to why previous wide-angle radar sounding studies did not reproduce Robin's findings. RP KOVACS, A (reprint author), CORPS ENGINEERS,COLD REG RES & ENGN LAB,APPL RES BRANCH,HANOVER,NH 03755, USA. NR 44 TC 97 Z9 100 U1 1 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD MAY PY 1995 VL 23 IS 3 BP 245 EP 256 DI 10.1016/0165-232X(94)00016-Q PG 12 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA RE789 UT WOS:A1995RE78900004 ER PT J AU ENSLEY, RJ BROWNE, WT AF ENSLEY, RJ BROWNE, WT TI ENDOTOXIN-NEUTRALIZING PROTEIN SO CRITICAL CARE MEDICINE LA English DT Letter RP ENSLEY, RJ (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA 30905, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD MAY PY 1995 VL 23 IS 5 BP 983 EP 983 DI 10.1097/00003246-199505000-00036 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA QX807 UT WOS:A1995QX80700036 PM 7736764 ER PT J AU COHEN, SR POLSE, KA BRAND, RJ BONANNO, JA AF COHEN, SR POLSE, KA BRAND, RJ BONANNO, JA TI THE ASSOCIATION BETWEEN PH LEVEL AND CORNEAL RECOVERY FROM INDUCED EDEMA SO CURRENT EYE RESEARCH LA English DT Article DE CORNEAL FUNCTION; CORNEAL HYDRATION; PH; STROMAL ACIDOSIS; FLUOROPHOTOMETRY; HUMAN ID HYDRATION CONTROL; STROMAL-PH; AGE; EYE AB Corneal acidosis has been shown to reduce corneal hydration control (CHC) as measured by the rate, expressed as the percent recovery per hour (PRPH), at which the thickness of the cornea decreases exponentially after an increased hydration load. Since the effect of pH on corneal function is of scientific interest and may have clinical implications, we explored the relationship between pH and PRPH in greater detail by examining the effect of different stromal pH levels on corneal hydration control. Corneal edema was induced using a 90-min exposure to wearing a hypoxic contact lens (CL). Following removal of the CL, random assignment over four eye-test combinations of either 0, 3, 5, and 7% CO2 were made while pH and corneal thickness were monitored using slit lamp fluorophometry and optical pachometry to measure corneal pH and corneal thickness, respectively. From these measurements we determined the pH-dose/PRPH relationship. The average stromal pH +/- 1SD resulting from exposure to either the 0, 3, 5, and 7% CO2, was 7.65 +/- 0.11, 7.30 +/- 0.09, 7.15 +/- 0.08 and 7.04 +/- 0.07 (p < 0.001), respectively. Analysis based on a quadratic model of the dose-response relationship between PRPH and corneal pH indicates that PRPH is relatively unchanged for pH in the physiological range (pH = 7.40-7.65) and then decreases notably below the physiological range. C1 UNIV CALIF BERKELEY,SCH OPTOMETRY,MORTON D SARVER LAB CORNEA & CONTACT LENS RES,BERKELEY,CA 94720. USA,ENVIRONM HYG AGCY,ABERDEEN PROVING GROUND,MD 21010. UNIV CALIF BERKELEY,SCH PUBL HLTH,BERKELEY,CA 94720. FU NEI NIH HHS [R01 EY04390, R01 EY07728] NR 20 TC 11 Z9 12 U1 0 U2 2 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0271-3683 J9 CURR EYE RES JI Curr. Eye Res. PD MAY PY 1995 VL 14 IS 5 BP 349 EP 355 DI 10.3109/02713689508999932 PG 7 WC Ophthalmology SC Ophthalmology GA QZ460 UT WOS:A1995QZ46000003 PM 7648860 ER PT J AU KRINITZSKY, EL AF KRINITZSKY, EL TI PROBLEMS WITH LOGIC TREES IN EARTHQUAKE HAZARD EVALUATION SO ENGINEERING GEOLOGY LA English DT Editorial Material AB Logic trees make sense when used in earthquake risk analysis where costs are compared for specific outcomes. However logic trees fail in earthquake hazard analysis when they are used to develop earthquake ground motions for applications in engineering. The failure stems from a misguided attempt to assign numbers for degrees of belief which are personal and indefinable, almost like love or taste, and for which there are neither tests nor measurements. The result is a complicated jumble of egocentric impressions. In contrast, the need in engineering is to have values that are based as much as possible on evidence. RP KRINITZSKY, EL (reprint author), CORPS ENGINEERS,WATERWAYS EXPT STN,GEOTECH LAB,VICKSBURG,MS, USA. NR 0 TC 14 Z9 14 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD MAY PY 1995 VL 39 IS 1-2 BP 1 EP 3 DI 10.1016/0013-7952(94)00060-F PG 3 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA RA791 UT WOS:A1995RA79100001 ER PT J AU TOUSSAINT, MW SHEDD, TR VANDERSCHALIE, WH LEATHER, GR AF TOUSSAINT, MW SHEDD, TR VANDERSCHALIE, WH LEATHER, GR TI A COMPARISON OF STANDARD ACUTE TOXICITY TESTS WITH RAPID-SCREENING TOXICITY TESTS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE ACUTE TOXICITY; TOXICITY TEST; SCREENING TESTS ID FRESH-WATER ORGANISMS; DAPHNIA-MAGNA STRAUS; CERIODAPHNIA-DUBIA; MYSIDOPSIS-BAHIA; FATHEAD MINNOW; SELENASTRUM-CAPRICORNUTUM; AQUATIC ORGANISMS; MICROTOX TEST; CHEMICALS; BIOASSAYS AB This study compared the relative sensitivity of five inexpensive, rapid toxicity tests to the sensitivity of five standard aquatic acute toxicity tests through literature review and testing. The rapid toxicity tests utilized organisms that require little culturing or handling prior to testing: a freshwater rotifer (Branchionus calyciflorus); brine shrimp (Artemia salina); lettuce (Loctuca sativa); and two microbial tests (Photobacterium phosphoreum - Microtox((R)) test, and a mixture of bacterial species - the Polytox((R)) test). Standard acute toxicity test species included water fleas (Daphnia magna and Ceriodaphnia dubia), green algae (Selenastrum capricornutum), fathead minnows (Pimephales promelas), and mysid shrimp (Mysidopsis bahia). Sensitivity comparisons between rapid and standard acute toxicity tests were based on LC50/EC5D data from 11 test chemicals. Individually, the lettuce and rotifer tests ranked most similar in sensitivity to the standard tests, while Microtox fell just outside the range of sensitivities represented by the group of standard acute toxicity tests. The brine shrimp and Polytox tests were one or more orders of magnitude different from the standard acute toxicity tests for most compounds. The lettuce, rotifer, and Microtox tests could be used as a battery for preliminary toxicity screening of chemicals. Further evaluation of complex ''real-world'' environmental samples is recommended. C1 USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. US EPA,WASHINGTON,DC 20460. HOOD COLL,DEPT BIOL,FREDERICK,MD 21701. RP TOUSSAINT, MW (reprint author), GEOCENTERS INC,10903 INDIAN HEAD HWY,FT WASHINGTON,MD 20744, USA. NR 95 TC 125 Z9 126 U1 2 U2 46 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAY PY 1995 VL 14 IS 5 BP 907 EP 915 DI 10.1897/1552-8618(1995)14[907:ACOSAT]2.0.CO;2 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA QV456 UT WOS:A1995QV45600024 ER PT J AU SHAPIRO, Y MORAN, D EPSTEIN, Y STROSCHEIN, L PANDOLF, KB AF SHAPIRO, Y MORAN, D EPSTEIN, Y STROSCHEIN, L PANDOLF, KB TI VALIDATION AND ADJUSTMENT OF THE MATHEMATICAL PREDICTION MODEL FOR HUMAN SWEAT RATE RESPONSES TO OUTDOOR ENVIRONMENTAL-CONDITIONS SO ERGONOMICS LA English DT Article DE SWEAT RATE; HEAT LOAD; THERMOREGULATION; MODELS ID TEMPERATURE AB Based on indoor laboratory studies, a mathematical model to predict sweat loss response was suggested as follows: m(sw) = 27.9E(req)(E(max))(-0.455) (g . m(-2). h(-1)) Under outdoor conditions this model was over estimating sweat loss response in shaded (low solar radiation) environments, and underestimating the response when solar radiation was high (open field areas). The present study was conducted in order to adjust the model to be applicable under outdoor environmental conditions. Four groups of fit acclimated subjects participated in the study. They were exposed to three climatic conditions (30 degrees, 65% rh; 31 degrees C, 40% rh; and 40 degrees C, 20% rh) and three levels of metabolic rate (100, 300 and 450 W) in shaded and sunny areas while wearing shorts, cotton fatigues (BDUs) or protective garments. The original predictive equation for sweat loss was adjusted for the outdoor conditions by evaluating separately the radiative heat exchange, short-wave absorption in the body and long-wave emission from the body to the atmosphere and integrating them in the required evaporation component (E(req)) of the model, as follows: H-r = 1.5SL(0.6)/I-T (watt) H-l = 0.047M(e.th)/I-T (watt), where SL is solar radiation (W . m(-2)), M(e.th) is the Stephan Boltzman constant, and I-T is the effective clothing insulation coefficient. This adjustment revealed a high correlation between the measured and expected values of sweat loss (r = 0.99, p < 0.0001). C1 SACKLER FAC MED,TEL AVIV,ISRAEL. USA,ENVIRONM MED RES INST,ENVIRONM PHYSIOL & MED DIRECTORATE,NATICK,MA 01760. RP SHAPIRO, Y (reprint author), CHAIM SHEBA MED CTR,HELLER INST MED RES,IL-52621 TEL HASHOMER,ISRAEL. NR 13 TC 16 Z9 16 U1 0 U2 7 PU TAYLOR & FRANCIS LTD LONDON PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0014-0139 J9 ERGONOMICS JI Ergonomics PD MAY PY 1995 VL 38 IS 5 BP 981 EP 986 DI 10.1080/00140139508925164 PG 6 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA QR632 UT WOS:A1995QR63200009 PM 7737107 ER PT J AU MORAN, D SHAPIRO, Y EPSTEIN, Y BURSTEIN, R STROSCHEIN, L PANDOLF, KB AF MORAN, D SHAPIRO, Y EPSTEIN, Y BURSTEIN, R STROSCHEIN, L PANDOLF, KB TI VALIDATION AND ADJUSTMENT OF THE MATHEMATICAL PREDICTION MODEL FOR HUMAN RECTAL TEMPERATURE RESPONSES TO OUTDOOR ENVIRONMENTAL-CONDITIONS SO ERGONOMICS LA English DT Article DE RECTAL TEMPERATURE; HEAT LOAD; THERMOREGULATION; MODELS ID LOADS AB Models to predict rectal temperature (T-re) have been based on indoor laboratory studies. The present study was conducted to validate and adjust a previously suggested model for outdoor environmental conditions. Four groups of young male volunteers were exposed to three different climatic conditions (30 degrees C, 65% rh; 31 degrees C, 41% rh; 40 degrees C, 20% rh). They were tested both in shaded and open field areas (radiation: 80 and 900 W . m(-2), respectively) at different work loads (100, 300 and 450 watt). Exercise consisted of two bouts of 10 minutes rest and 50 minutes walking on a treadmill, at a constant speed (1.4 m . s(-1)) and different grades. The subjects were tested wearing cotton fatigues and protective garments. Their T-re and heart rate were monitored every 5 min and skin temperature every 15 min, oxygen uptake was measured towards the end of each bout of exercise; concomitantly, ambient temperature, relative humidity and solar load were monitored. We concluded that: (a) the corrected model to predict rectal temperature overestimates the actual measurements when applied outdoors; (b) radiative and convective heat exchanges should be considered separately when using the model outdoors; (c) radiative heat exchange should also be considered separately for short-wave radiation (solar radiation) and long-wave emission from the body to the atmosphere. Finally, an adjusted model to be used outdoors was suggested. C1 SACKLER FAC MED,TEL AVIV,ISRAEL. USA,ENVIRONM MED RES INST,ENVIRONM PHYSIOL & MED DIRECTORATE,NATICK,MA 01760. RP MORAN, D (reprint author), CHAIM SHEBA MED CTR,HELLER INST MED RES,IL-52621 TEL HASHOMER,ISRAEL. NR 17 TC 3 Z9 3 U1 0 U2 1 PU TAYLOR & FRANCIS LTD LONDON PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0014-0139 J9 ERGONOMICS JI Ergonomics PD MAY PY 1995 VL 38 IS 5 BP 1011 EP 1018 DI 10.1080/00140139508925167 PG 8 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA QR632 UT WOS:A1995QR63200012 PM 7737098 ER PT J AU WAAG, D CHULAY, J MARRIE, T ENGLAND, M WILLIAMS, J AF WAAG, D CHULAY, J MARRIE, T ENGLAND, M WILLIAMS, J TI VALIDATION OF AN ENZYME-IMMUNOASSAY FOR SERODIAGNOSIS OF ACUTE Q-FEVER SO EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; COXIELLA-BURNETII; PHASE-I; IMMUNOGLOBULIN RESPONSES; ANTIBODY-RESPONSE; IMMUNE-RESPONSE; PARTURIENT CAT; OUTBREAK; PNEUMONIA AB An enzyme immunoassay was validated for the serodiagnosis of acute Q fever. Minimum positive tests were determined for both serial dilutions and a single dilution of patient sera. To establish the specificity of the test, 152 serum samples were tested from individuals with no evidence of past Coxiella burnetii infection. Diagnostic titers were set at greater than or equal to 128 for the IgM and IgG responses to phase I, at greater than or equal to 512 for the IgM response to phase II and at greater than or equal to 1,024 for the IgG response to phase II Coxiella burnetii These titers gave a false-positive rate of less than or equal to 1 %. Alternatively, testing a single dilution of sera (1:128) gave specificities ranging from 97.3 to 98.7 %. Tests with the greatest sensitivities, using serially diluted early convalescent-phase sera, were the IgM (84 %) and IgG (80 %) responses to phase II Coxiella burnetii. At a single serum dilution, 92 % of early convalescent sera had a positive IgG response to phase II Coxiella burnetii With a high specificity and good sensitivity, the EIA can be used to diagnose acute Q fever with a single convalescent serum specimen. The duration of a positive response was greater than five years. C1 BURROUGHS WELLCOME CO,DEPT INFECT DIS & IMMUNOL,RES TRIANGLE PK,NC 27709. VICTORIA GEN HOSP,HALIFAX,NS B3H 2Y9,CANADA. US FDA,DIV VACCINES & RELATED PROD APPLICAT,OFF VACCINE RES & REVIEW,ROCKVILLE,MD 20852. RP WAAG, D (reprint author), USA,MED RES INST INFECT DIS,PATHOGENESIS & IMMUNOL BRANCH,FREDERICK,MD 21702, USA. NR 20 TC 28 Z9 30 U1 0 U2 1 PU FRIEDR VIEWEG SOHN VERLAG GMBH PI WIESBADEN 1 PA PO BOX 5829, W-6200 WIESBADEN 1, GERMANY SN 0934-9723 J9 EUR J CLIN MICROBIOL JI Eur. J. Clin. Microbiol. Infect. Dis. PD MAY PY 1995 VL 14 IS 5 BP 421 EP 427 DI 10.1007/BF02114898 PG 7 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA RE119 UT WOS:A1995RE11900007 PM 7556231 ER PT J AU HAMMELMAN, TL AF HAMMELMAN, TL TI THE PERSIAN-GULF CONFLICT - THE IMPACT OF STRESSORS AS PERCEIVED BY ARMY RESERVISTS SO HEALTH & SOCIAL WORK LA English DT Article DE FAMILIES; MILITARY; PERSIAN GULF CONFLICT; STRESS ID DISORDER AB This study examines the extent to which certain stressors influenced U.S. Army Reserve soldiers and their families as a result of the Persian Gulf conflict. Family composition, location of the soldier, rank, and gender were variables used to make comparisons of how the stressors affected soldiers and their families. Results revealed that married soldiers suffered from greater stress overall than single soldiers. Lower ranking soldiers and their families were affected less by the stressors outlined in this study than higher ranking soldiers and their families. Female soldiers were influenced less by the stressors than their male counterparts. Single-parent families handled the stressors better than two-parent families, and families with three or more school-age children responded better to the stress indicators than families with no children in school. On the basis of these results, clinical implications are discussed. C1 USA,INDIVIDUAL READY RESERVE,CTR PERSONNEL,ST LOUIS,MO. WENDY PAINE OBRIEN RESIDENTIAL TREATMENT CTR,PHOENIX,AZ. NR 12 TC 6 Z9 6 U1 0 U2 0 PU NATL ASSOC SOCIAL WORKERS PI WASHINGTON PA 750 FIRST ST, NE, STE 700, WASHINGTON, DC 20002-4241 SN 0360-7283 J9 HEALTH SOC WORK JI Health Soc. Work PD MAY PY 1995 VL 20 IS 2 BP 140 EP 145 PG 6 WC Social Work SC Social Work GA QW377 UT WOS:A1995QW37700010 PM 7649507 ER PT J AU LACKEY, RJ UPMAL, DW AF LACKEY, RJ UPMAL, DW TI SPEAKEASY - THE MILITARY SOFTWARE RADIO SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article C1 USA,CECOM,SPACE & TERR COMMUN DIRECTORATE,SPECIAL PROJECTS OFF,FT MONMOUTH,NJ. RP LACKEY, RJ (reprint author), HAZELTINE CORP,ADAPT SIGNAL PROC LAB,GREENLAWN,NY, USA. NR 0 TC 58 Z9 64 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0163-6804 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD MAY PY 1995 VL 33 IS 5 BP 56 EP 61 DI 10.1109/35.392998 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA QW780 UT WOS:A1995QW78000007 ER PT J AU KOSCICA, TE ZHAO, JH AF KOSCICA, TE ZHAO, JH TI FIELD-EFFECT REAL-SPACE TRANSFER TRANSISTOR SO IEEE ELECTRON DEVICE LETTERS LA English DT Article ID HETEROSTRUCTURES; TRANSPORT; LOGIC AB We report demonstration of the first Field Effect Real Space transfer Transistor (FERST), a gated real space carrier transfer device, It is a dual output, multifunctional device which, depending on region of operation, demonstrates either of three characteristics: traditional FET transconductance, sign reversing transconductance, or dual output with near complimentary transconductances. Additionally, the FERST structure provides a new means for exploring the physics of real space transfer. C1 RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. RP KOSCICA, TE (reprint author), USA,RES LAB,DIV MICROWAVE,MONMOUTH,NJ 07703, USA. NR 10 TC 4 Z9 4 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD MAY PY 1995 VL 16 IS 5 BP 196 EP 198 DI 10.1109/55.382238 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA QW571 UT WOS:A1995QW57100014 ER PT J AU LIN, MJ HSIEH, JW DU, DHC THOMAS, JP MACDONALD, JA AF LIN, MJ HSIEH, JW DU, DHC THOMAS, JP MACDONALD, JA TI DISTRIBUTED NETWORK COMPUTING OVER LOCAL ATM NETWORKS SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article AB Communication between processors has long been the bottleneck of distributed network computing. However, recent progress in switch-based high-speed local area networks (LAN's) may be changing this situation, Asynchronous transfer mode (ATM) is one of the most widely-accepted and emerging high-speed network standards which can potentially satisfy the communication needs of distributed network computing, In this paper, we investigate distributed network computing over local ATM networks, We first study the performance characteristics involving end-to-end communication in an environment that includes several types of workstations interconnected via a Fore Systems' ASX-100 ATM Switch, We then compare the communication performance of four different application programming interfaces (API's), The four API's were Fore Systems' ATM API, the BSD socket programming interface, Sun's remote procedure call (RPC), and the parallel virtual machine (PVM) message passing library, Each API represents distributed programming at a different communication protocol layer, We evaluated two popular distributed applications, parallel matrix multiplication and parallel partial differential equations, over the local ATM network, The experimental results show that network computing is promising over local ATM networks, provided that the higher level protocols, device drivers, and network interfaces are improved. C1 UNIV MINNESOTA,CTR DISTRIBUTED MULTIMEDIA,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,DEPT COMP SCI,MINNEAPOLIS,MN 55455. MINNESOTA SUPERCOMP CTR INC,MINNEAPOLIS,MN 55415. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RP LIN, MJ (reprint author), APPLE COMP INC,ADV TECHNOL GRP,CUPERTINO,CA 95014, USA. NR 22 TC 10 Z9 10 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD MAY PY 1995 VL 13 IS 4 BP 733 EP 748 DI 10.1109/49.382163 PG 16 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA QW246 UT WOS:A1995QW24600012 ER PT J AU CHOI, K SALON, SJ CONNOR, KA LIBELO, LF HAHN, SY AF CHOI, K SALON, SJ CONNOR, KA LIBELO, LF HAHN, SY TI TIME-DOMAIN FINITE-ELEMENT ANALYSIS OF HIGH-POWER MICROWAVE APERTURE ANTENNAS SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 6th Biennial IEEE Conference on Electromagnetic Field Computation (CEFC 94) CY JUL 05-07, 1994 CL AIX LES BAINS, FRANCE SP IEEE, MAGNET SOC, SOC ELECTRICIENS & ELECTRONICIENS, GRP DAUPHINE SAVOIES, LAB ELETROTECH GRENOBLE ID RADIATION AB A high power microwave device with complicated structure is analyzed in the time domain using the Finite Element Scheme which utilizes triangular elements. The convergence property is investigated and comparisons between conventional methods are shown. Results are also compared with frequency domain analysis. C1 RENSSELAER POLY INST,DEPT ECSE,TROY,NY 12180. USA,SERV,ADELPHI,MD 20783. SEOUL NATL UNIV,DEPT ELECT E,SEOUL 151742,SOUTH KOREA. RP CHOI, K (reprint author), RENSSELAER POLY INST,DEPT ELECT POWER ENGN,TROY,NY 12180, USA. NR 10 TC 14 Z9 14 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD MAY PY 1995 VL 31 IS 3 BP 1622 EP 1625 DI 10.1109/20.376344 PN 1 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA QR394 UT WOS:A1995QR39400077 ER PT J AU ABOUDPIRAK, E LUBIN, I PIRAK, ME CANAAN, A LOWELL, GH REISNER, Y AF ABOUDPIRAK, E LUBIN, I PIRAK, ME CANAAN, A LOWELL, GH REISNER, Y TI LETHALLY IRRADIATED NORMAL STRAINS OF MICE RADIOPROTECTED WITH SCID BONE-MARROW DEVELOP SENSITIVITY TO LOW-DOSES OF STAPHYLOCOCCAL-ENTEROTOXIN-E SO IMMUNOLOGY LETTERS LA English DT Article DE MHC CLASS II STRUCTURE; SEVERE COMBINED IMMUNE DEFICIENCY; STAPHYLOCOCCAL ENTEROTOXIN B; TOTAL BODY IRRADIATION; T-CELL RECEPTOR ID T-CELLS AB Normal strains of mice are rendered sensitive to small amounts (3-10 mu g) of staphylococcal enterotoxin B (SEB) by transplanting bone marrow cells of SCID donor mice to lethally irradiated recipients. Four to 12 weeks post-transplantation, SEB induces 56-100% lethality. Transplantation of normal mouse bone marrow cells, either alone or with the SCID mouse selected bone marrow cells, does not confer SEB sensitivity. These data imply that either irradiation ablates certain cell population(s), that confer resistance to SEB in normal mice (populations that are absent in the SCID donor mice) or that the donor cells selectively repopulate recipients with SEB-sensitive cells. This model will help elucidate the cells, cytokines and the SEB peptide fragments responsible for SEB toxicity and will be useful in identifying promising vaccine candidates and in developing preventive medicines to protect against this potent toxin. C1 WEIZMANN INST SCI,DEPT MEMBRANE RES & BIOPHYS,IL-76100 REHOVOT,ISRAEL. WEIZMANN INST SCI,DEPT CHEM IMMUNOL,IL-76100 REHOVOT,ISRAEL. WALTER REED ARMY INST RES,WASHINGTON,DC. NR 8 TC 7 Z9 8 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2478 J9 IMMUNOL LETT JI Immunol. Lett. PD MAY PY 1995 VL 46 IS 1-2 BP 9 EP 14 DI 10.1016/0165-2478(94)00005-C PG 6 WC Immunology SC Immunology GA RC440 UT WOS:A1995RC44000003 PM 7590935 ER PT J AU VANDEVERG, LL MALLETT, CP COLLINS, HH LARSEN, T HAMMACK, C HALE, TL AF VANDEVERG, LL MALLETT, CP COLLINS, HH LARSEN, T HAMMACK, C HALE, TL TI ANTIBODY AND CYTOKINE RESPONSES IN A MOUSE PULMONARY MODEL OF SHIGELLA-FLEXNERI SEROTYPE 2A INFECTION SO INFECTION AND IMMUNITY LA English DT Article ID VACCINE; CELLS; EFFICACY; MONKEYS; SONNEI AB A murine pulmonary model was used to study the mucosal immune response to Shigella flexneri serotype 2a infection. Inoculation of BALB/cJ mice with shigellae via the intranasal route resulted in bacterial invasion of bronchial and alveolar epithelia with concomitant development of acute suppurative bronchiolitis and subsequent development of lethal pneumonia. The pathology of pulmonary lesions resembled the colitis that characterizes shigellosis in humans and primates. Significant protection against a lethal dose of S. flexneri 2a was observed in mice previously infected with two sublethal doses of the homologous strain. Immunity against lethal challenge was associated with decreased bacterial invasion of the mucosal epithelium. Over the course of two sublethal challenges, which constituted primary and secondary immunizations, mice developed pulmonary and serum immunoglobulin G and A antibody recognizing both lipopolysaccharide and invasion plasmid antigens IpaB and IpaC. Immune mice and naive control mice differed in lung lavage cytokine levels following lethal challenge. Immune mice developed significantly elevated levels of pulmonary gamma interferon within 6 h of challenge, while naive control mice developed elevated levels of this cytokine later during the initial 24-h period. Both groups had elevated levels of gamma interferon during the 24- to 48-h period of infection. Both groups also had elevated levels of tumor necrosis factor alpha within 6 h of challenge, but the control mice had significantly higher levels at the 48- and 72-h time points. Elevated levels of interleukin-il were observed only in immunized mice. This cytokine appeared within 24 h and receded between 48 and 72 h. Fluorescence-activated cell sorter analysis of lung parenchymal cells showed that both groups experienced an initial influx of monocytes, but the proportion of this cell type began to recede in immunized mice after 48 h of infection, while peak levels were maintained in the control animals. These studies suggest that elements of local B lymphocyte activity, as well as Th-1 and Th-2 lymphocyte activity, may contribute to the survival of immune mice after intranasal challenge with shigellae. C1 WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT COMPARAT PATHOL,WASHINGTON,DC 20307. RP VANDEVERG, LL (reprint author), WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 27 TC 71 Z9 71 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 1995 VL 63 IS 5 BP 1947 EP 1954 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA QU941 UT WOS:A1995QU94100049 PM 7729907 ER PT J AU SMITH, KJ SKELTON, HG WAGNER, KF AF SMITH, KJ SKELTON, HG WAGNER, KF TI PATHOGENESIS OF HIV-1 DISEASE SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Review ID IMMUNODEFICIENCY-VIRUS TYPE-1; T-CELL SUBSETS; WALTER-REED STAGE; LYMPHOCYTES-T; CLASS-II; IMMUNOHISTOCHEMICAL FINDINGS; INFLAMMATORY DERMATOSES; MONOCLONAL-ANTIBODIES; INFECTED INDIVIDUALS; BEARING LYMPHOCYTES C1 ARMED FORCES INST PATHOL,WALTER REED ARMY INST RES,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. HENRY M JACKSON FDN,BETHESDA,MD. NR 90 TC 2 Z9 2 U1 0 U2 0 PU DECKER PERIODICALS INC PI HAMILTON PA 4 HUGHSON ST, PO BOX 620, LCD 1, HAMILTON ON L8N 3K7, CANADA SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD MAY PY 1995 VL 34 IS 5 BP 308 EP 318 DI 10.1111/j.1365-4362.1995.tb03609.x PG 11 WC Dermatology SC Dermatology GA QW655 UT WOS:A1995QW65500003 PM 7607789 ER PT J AU JENKINS, RA TEMOSHOK, LR VIROCHSIRI, K AF JENKINS, RA TEMOSHOK, LR VIROCHSIRI, K TI INCENTIVES AND DISINCENTIVES TO PARTICIPATE IN PROPHYLACTIC HIV VACCINE RESEARCH SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HIV VACCINE; VACCINE TRIALS; RESEARCH PARTICIPATION; INCENTIVES ID CLINICAL-TRIALS AB An anonymous cross-sectional paper-and-pencil survey was used to assess incentives and disincentives to participate in a Phase I preventive human immunodeficiency virus (HIV) vaccine trial in a potential Thai target population. A total of 255 persons employed in health care service and research settings completed questionnaires after attending informational briefings regarding the proposed vaccine product and the planned trial procedures, Willingness to participate was related to self-perceived benefits from joining a preventive vaccine trial, as well as to concerns about product safety and social discrimination that might result from participation. The distinction between positive results of enzyme-linked immunosorbent assay from vaccine administration and positivity from HIV infection was unclear for many participants. Men were more willing to participate than women, and there was a trend toward greater willingness to participate in those who were less educated, Preparations for preventive vaccine trials may be more successful if they emphasize personal benefits of trial participation, clearly address safety issues, and consider ways to prevent social discrimination against participants. C1 ROYAL THAI ARMY MED DEPT,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. MIL MED CONSORTIUM APPL RETROVIRAL RES,ROCKVILLE,MD. RP JENKINS, RA (reprint author), HENRY M JACKSON FDN ADV MIL MED,1 TAFT COURT,SUITE 250,ROCKVILLE,MD 20850, USA. NR 32 TC 33 Z9 35 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD MAY 1 PY 1995 VL 9 IS 1 BP 36 EP 42 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA QV577 UT WOS:A1995QV57700006 PM 7712233 ER PT J AU NASEEM, SM PACE, JG WANNEMACHER, RW AF NASEEM, SM PACE, JG WANNEMACHER, RW TI A HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR DETERMINING [H-3] T-2 AND ITS METABOLITES IN BIOLOGICAL-FLUIDS OF THE CYNOMOLGUS MONKEY SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID T-2 TOXIN; TRICHOTHECENE MYCOTOXINS; MICROSOMAL DEACETYLATION; FATE; PHARMACOKINETICS; QUANTITATION; FUSARIA; CATTLE; MICE RP NASEEM, SM (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 27 TC 4 Z9 4 U1 2 U2 2 PU PRESTON PUBLICATIONS INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol PD MAY-JUN PY 1995 VL 19 IS 3 BP 151 EP 156 PG 6 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA QX913 UT WOS:A1995QX91300004 PM 7564292 ER PT J AU PETRENKO, VF COLBECK, SC AF PETRENKO, VF COLBECK, SC TI GENERATION OF ELECTRIC-FIELDS BY ICE AND SNOW FRICTION SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SURFACE C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP PETRENKO, VF (reprint author), DARTMOUTH COLL,THAYER SCH ENGN,HANOVER,NH 03755, USA. NR 17 TC 13 Z9 13 U1 1 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 1 PY 1995 VL 77 IS 9 BP 4518 EP 4521 DI 10.1063/1.359448 PG 4 WC Physics, Applied SC Physics GA QV479 UT WOS:A1995QV47900043 ER PT J AU MARTIN, DG WATSON, CE GOLD, MB WOODARD, CL BASKIN, SI AF MARTIN, DG WATSON, CE GOLD, MB WOODARD, CL BASKIN, SI TI TOPICAL ANESTHETIC-INDUCED METHEMOGLOBINEMIA AND SULFHEMOGLOBINEMIA IN MACAQUES - A COMPARISON OF BENZOCAINE AND LIDOCAINE SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE BENZOCAINE(R); CETACAINE(R); LIDOCAINE(R); XYLOCAINE(R); TOPICAL LOCAL ANETHESIA; METHEMOGLOBIN(EMIA); SULFHEMOGLOBIN; MACACA NEMESTRINA; MACACA MULATTA ID CETACAINE; SHEEP AB Benzocaine (BNZ) and lidocaine (LC) are commonly used topical (spray) anesthetics approved for use in humans, Benzocaine has structural similarities to methemoglobin (MHb)-forming drugs that are current candidates for cyanide prophylaxis, while LC has been reported to increase MHb in man. In this study, we compared MHb and sulfhemoglobin (SHb) production in three groups of Macaques (Chinese rhesus and Indian rhesus (Macaca mulatta) and pig-tailed macaques (Macaca nemestrina)) after exposure to BNZ and LC, Formation of SHb, unlike MHb, is not thought to be reversible and therefore is considered to be of greater toxic significance, Both MHb and SHb Levels were measured periodically on a CO-Oximeter. All rhesus macaques (n = 8) were administered an intratracheal/intranasal) dose of 56 mg (low dose) or 280 mg (high dose) of BNZ or 40 mg of LC in a randomized cross-over design (all animals received all three treatments), Pig-tailed macaques (n = 6) were given an intranasal dose of 56 mg of BNZ and 40 mg of LC, As no differences in the peak MHb or time to peak (mean +/- SD) were observed among the three macaque subspecies, the data were pooled, Lidocaine did not cause MHb or SHb formation above baseline in any monkey, In contrast, all monkeys (n = 14) lad a significant elevation in peak MHb formation after 56 mg of BNZ, which ranged from 4.0% to 19.4% with an average of 8.6 +/- 4.0% (mean +/- SD), with peak MHb levels reached at 30 min, The monkeys given the high dose of BNZ (n = 8) demonstrated higher peak MHb levels (P < 0.05) than the lower dose of BNZ: 14.7 +/- 6.5% (mean +/- SD) as the time to peak increased to 45 min. Slight increases in SHb levels (0.02-0.04 mm l(-1) rise) measured (P < 0.05) after low and high BNZ doses were 54% and 75% higher than baseline SHb levels after LC, This study indicates that benzocaine applied topically in non-human primates can readily increase MHb concentrations within 30 min to clinically relevant levels required for cyanide prophylaxis, but LC does not, The variability in the peak Hb levels after BNZ is likely to be due to the variability in absorption and/or metabolism of the drug, In addition, the slight increase in SHb seen in BNZ groups should prompt investigators to also evaluate this toxic Hb component when evaluating MHb-forming drugs. C1 USA,MED RES INST CHEM DEF,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010. USA,MED RES INST CHEM DEF,DIV VET MED & LAB RESOURCES,ABERDEEN PROVING GROUND,MD 21010. USA,ENVIRONM HYG AGCY,DIV TOXICOL,ABERDEEN PROVING GROUND,MD 21010. NR 25 TC 14 Z9 14 U1 0 U2 2 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD MAY-JUN PY 1995 VL 15 IS 3 BP 153 EP 158 DI 10.1002/jat.2550150304 PG 6 WC Toxicology SC Toxicology GA RA018 UT WOS:A1995RA01800002 PM 7560734 ER PT J AU DRAZEK, ES STEIN, DC DEAL, CD AF DRAZEK, ES STEIN, DC DEAL, CD TI A MUTATION IN THE NEISSERIA-GONORRHOEAE RFAD HOMOLOG RESULTS IN ALTERED LIPOOLIGOSACCHARIDE EXPRESSION SO JOURNAL OF BACTERIOLOGY LA English DT Article ID ESCHERICHIA-COLI K-12; POLYACRYLAMIDE GELS; GONOCOCCAL LIPOPOLYSACCHARIDE; SERUM RESISTANCE; OUTER-MEMBRANE; SEQUENCE; GENE; HETEROGENEITY; BIOSYNTHESIS; 4-EPIMERASE AB The gonococcal lsi-6 locus was cloned and shown by DNA sequence analysis to have homology with the E. coli rfaD gene, which encodes ADP-L-glycero-D-mannoheptose epimerase. This enzyme is involved in the biosynthesis of the lipopolysaccharide precursor ADP-L-glycero-D-mannoheptose. A site-directed frameshift mutation in lsi-6 was constructed by PCR amplification acid introduced into the chromosome of Neisseria gonorrhoeae MS11 P+ by transformation. The lipooligosaccharides (LOS) of mutant and parental strains were characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), The lsi-6 mutant produced LOS components with apparent molecular masses of 2.6 and 3.6 kDa as compared with a 3.6-kDa band of the MS11 P+ strain. The parental LOS phenotype was expressed when a revertant was constructed by transformation of the cloned wild-type gene into the lsi-6 mutant. The immunoreactivity of LOS from parental and constructed strains was examined by SDS-PAGE and Western blotting. Only the parental and reconstructed wild-type strains produced a 3.6-kDa LOS component that reacted with monoclonal antibody 2-1-L8. These results suggest that the lsi-6 locus is involved in gonococcal LOS biosynthesis and that the nonreactive mutant 3.6-kDa LOS component contains a conformational change or altered saccharide composition that interferes with immunoreactivity. C1 WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT BACTERIAL DIS, WASHINGTON, DC 20307 USA. UNIV MARYLAND, DEPT MICROBIOL, COLLEGE PK, MD 20742 USA. NR 52 TC 21 Z9 22 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 EI 1098-5530 J9 J BACTERIOL JI J. Bacteriol. PD MAY PY 1995 VL 177 IS 9 BP 2321 EP 2327 PG 7 WC Microbiology SC Microbiology GA QW529 UT WOS:A1995QW52900012 PM 7730260 ER PT J AU FARCHAUS, JW RIBOT, WJ DOWNS, MB EZZELL, JW AF FARCHAUS, JW RIBOT, WJ DOWNS, MB EZZELL, JW TI PURIFICATION AND CHARACTERIZATION OF THE MAJOR SURFACE ARRAY PROTEIN FROM THE AVIRULENT BACILLUS-ANTHRACIS DELTA-STERNE-1 SO JOURNAL OF BACTERIOLOGY LA English DT Article ID CELL-WALL PROTEIN; ADENYLATE-CYCLASE; ESCHERICHIA-COLI; FACTOR GENE; S-LAYER; ENCAPSULATION; EXPRESSION; ANTIGENS; PLASMID; CLONING AB Many prokaryotic organisms possess surface layer (S-layer) proteins that are components of the outermost cell envelope. With immunogold labeling, it was demonstrated that the protein extractable antigen 1 (EA1) was localized on the outer surface and specifically to cell wall fragments from Bacillus anthracis which retained the S layer. When grown in rich medium under aerobic conditions, the avirulent strain Delta Sterne-1 released large amounts of EA1 into the medium, This EA1 had no higher-order structure initially but formed two-dimensional crystals under defined conditions, The released EA1 was purified in aqueous buffers with a three-step procedure and found to have a mass of 95 kDa when subjected to denaturing sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), N-terminal sequence data revealed exact identity to the first eight residues of the S-layer protein from B, thuringiensis 4045. Gel permeation chromatography of the purified EA1 under nondenaturing conditions revealed a single peak corresponding to a mass of approximately 400 kDa, suggesting that a tetramer or dimer of dimers was the primary species in solution, SDS-PAGE of EA1 purified in the absence of protease inhibitors revealed specific proteolytic processing to an 80-kDa form, which immunoreacted with polyclonal anti-EA1 antibodies. This proteolytic cleavage of EA1 to 80 MDa was duplicated with purified EA1 and the protease trypsin or pronase. C1 USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV APPL RES,FREDERICK,MD 21702. RP FARCHAUS, JW (reprint author), USA,MED RES INST INFECT DIS,DIV BACTERIOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 37 TC 12 Z9 14 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD MAY PY 1995 VL 177 IS 9 BP 2481 EP 2489 PG 9 WC Microbiology SC Microbiology GA QW529 UT WOS:A1995QW52900033 PM 7730281 ER PT J AU JAFFE, DJ LATIMER, ME AF JAFFE, DJ LATIMER, ME TI TRANSIENT THALAMIC ABNORMALITY IN ASSOCIATION WITH SEIZURE SO JOURNAL OF CHILD NEUROLOGY LA English DT Note ID EMISSION COMPUTED-TOMOGRAPHY; PARTIAL STATUS EPILEPTICUS; FOCAL STATUS EPILEPTICUS; BRAIN-LESIONS; CT SCAN; MRI; HYPODENSITY; EPILEPSY C1 UNIFORMED SERV UNIV HLTH SCI,WALTER REED ARMY MED CTR,WASHINGTON,DC. RP JAFFE, DJ (reprint author), USA,WOMACK MED CTR,DEPT PSYCHIAT & NEUROL,FT BRAGG,NC, USA. NR 25 TC 2 Z9 2 U1 0 U2 2 PU DECKER PERIODICALS INC PI HAMILTON PA 4 HUGHSON ST, PO BOX 620, LCD 1, HAMILTON ON L8N 3K7, CANADA SN 0883-0738 J9 J CHILD NEUROL JI J. Child Neurol. PD MAY PY 1995 VL 10 IS 3 BP 243 EP 245 PG 3 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA QX383 UT WOS:A1995QX38300016 PM 7642899 ER PT J AU STURM, M HOLMGREN, J LISTON, GE AF STURM, M HOLMGREN, J LISTON, GE TI A SEASONAL SNOW COVER CLASSIFICATION-SYSTEM FOR LOCAL TO GLOBAL APPLICATIONS SO JOURNAL OF CLIMATE LA English DT Article ID DEPTH-HOAR; PRECIPITATION; ALASKA; MODEL; FLOW AB A new classification system for seasonal snow covers is proposed. It has six classes (tundra, taiga, alpine, maritime, prairie, and ephemeral), each class defined by a unique ensemble of textural and stratigraphic characteristics including the sequence of snow layers, their thickness, density, and the crystal morphology and grain characteristics within each layer. The classes can also be derived using a binary system of three climate variables: wind, precipitation, and air temperature. Using this classification system, the Northern Hemisphere distribution of the snow cover classes is mapped on a 0.5 degrees lat X 0.5 degrees long grid. These maps are compared to maps prepared from snow cover data collected in the former Soviet Union and Alaska. For these areas where both climatologically based and texturally based snow cover maps are available, there is 62% and 90% agreement, respectively. Five of the six snow classes are found in Alaska. From 1989 through 1992, hourly measurements, consisting of 40 thermal and physical parameters, including snow depth, the temperature distribution in the snow, and basal heat flow, were made on four of these classes. In addition, snow stratigraphy and texture were measured every six weeks. Factor analysis indicates that the snow classes can be readily discriminated using four or more winter average thermal or physical parameters. Further, analysis of hourly time series indicates that 84% of the time, spot measurements of the parameters are sufficient to correctly differentiate the snow cover class. Using the new snow classification system, 1) classes can readily be distinguished using observations of simple thermal parameters, 2) physical and thermal attributes of the snow can be inferred, and 3) classes can be mapped from climate data for use in regional and global climate modeling. C1 COLORADO STATE UNIV,DEPT ATMOSPHER SCI,FT COLLINS,CO 80523. RP STURM, M (reprint author), USA,COLD REG RES & ENGN LAB,POB 35170,FT WAINWRIGHT,AK 99703, USA. NR 72 TC 276 Z9 286 U1 2 U2 55 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0894-8755 J9 J CLIMATE JI J. Clim. PD MAY PY 1995 VL 8 IS 5 BP 1261 EP 1283 DI 10.1175/1520-0442(1995)008<1261:ASSCCS>2.0.CO;2 PN 2 PG 23 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA RB232 UT WOS:A1995RB23200002 ER PT J AU SMITH, DV SMITH, S BENDER, GN CARTER, JR KIM, Y CAWTHON, MA LECKIE, RG WEISER, JC ROMLEIN, J GOERINGER, F AF SMITH, DV SMITH, S BENDER, GN CARTER, JR KIM, Y CAWTHON, MA LECKIE, RG WEISER, JC ROMLEIN, J GOERINGER, F TI EVALUATION OF THE MEDICAL DIAGNOSTIC-IMAGING SUPPORT SYSTEM BASED ON 2 YEARS OF CLINICAL-EXPERIENCE SO JOURNAL OF DIGITAL IMAGING LA English DT Article DE FILMLESS HOSPITAL; MEDICAL DIAGNOSTIC IMAGING SUPPORT (MDIS) SYSTEM; PICTURE ARCHIVING AND COMMUNICATION SYSTEM (PACS) ID COMPRESSION; RADIOGRAPHY; ACCURACY AB The Medical Diagnostic Imaging Support (MDIS) system at Madigan Army Medical Center (MAMC) has been operational in a phased approach since March 1992. Since then, nearly all image acquisition has been digital with progressively increasing primary softcopy diagnosis used. More than 375,000 computed radiography (CR) images as well as other modality images have been archived. Considerable experience in installation and implementation phasing has been gained. The location and ergonomic aspects of equipment placement were refined with time. The original clinical scenario was insufficiently detailed and additions were made to facilitate smoother and more complete transition toward a filmless environment. The MDIS system effectiveness and performance have been good in terms of operational workload throughput, background operations, and reliability. The important areas regarding reliability are image acquisition, output, display, database operations, storage, and the local area network. Fail-safe strategies have been continually improved to maintain continuous clinical image availability during the times when the MDIS system or components malfunction. Many invaluable lessons have been learned for effective quality assurance in a hospital-wide picture archiving and communication system. These issues include training, operational quality control, practical aspects of CR image quality, and increased timeliness in the generation and distribution of radiographic reports. Clinical acceptability has been a continuous process as each phase has been implemented. Clinical physicians quickly used the workstations soon after the start of MDIS at MAMC. The major advantage for clinicians has been the amount of time saved when retrieving multimodality images for review. On the other hand, the radiologists have been slower in their acceptance of the workstation for routine use. Radiologists need the completed software and hardware implementation to achieve the throughput necessary for a high-volume practice setting in making primary softcopy diagnoses. C1 UNIV WASHINGTON,DEPT ELECT ENGN,SEATTLE,WA 98195. BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234. USA,MED MAT AGCY,MED DIAGNOST IMAGING SUPPORT PROJECT,FREDERICK,MD. RP SMITH, DV (reprint author), MADIGAN ARMY MED CTR,DEPT RADIOL,TACOMA,WA 98431, USA. NR 35 TC 10 Z9 10 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0897-1889 J9 J DIGIT IMAGING JI J. Digit. Imaging PD MAY PY 1995 VL 8 IS 2 BP 75 EP 87 PG 13 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA QY343 UT WOS:A1995QY34300004 PM 7612705 ER PT J AU REAMS, GJ BAUMGARTNER, JC KULILD, JC AF REAMS, GJ BAUMGARTNER, JC KULILD, JC TI PRACTICAL APPLICATION OF INFECTION-CONTROL IN ENDODONTICS SO JOURNAL OF ENDODONTICS LA English DT Article AB The transmission of infections in an endodontic practice is a significant concern for both patients and dental health care providers, This article offers a review and practical application of infection control methods in the practice of endodontics. C1 USA,DENT ACTIV,FT SAM HOUSTON,TX. RP REAMS, GJ (reprint author), OREGON HLTH SCI UNIV,SCH DENT,DEPT ENDODONT,611 SW CAMPUS DR,PORTLAND,OR 97201, USA. NR 12 TC 5 Z9 7 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAY PY 1995 VL 21 IS 5 BP 281 EP 284 DI 10.1016/S0099-2399(06)80999-4 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA QW007 UT WOS:A1995QW00700009 PM 7673833 ER PT J AU UBELAKER, DH OWSLEY, DW HOUCK, MM CRAIG, E GRANT, W WOLTANSKI, T FRAM, R SANDNESS, K PEERWANI, N AF UBELAKER, DH OWSLEY, DW HOUCK, MM CRAIG, E GRANT, W WOLTANSKI, T FRAM, R SANDNESS, K PEERWANI, N TI THE ROLE OF FORENSIC ANTHROPOLOGY IN THE RECOVERY AND ANALYSIS OF BRANCH-DAVIDIAN COMPOUND VICTIMS - RECOVERY PROCEDURES AND CHARACTERISTICS OF THE VICTIMS SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE PHYSICAL ANTHROPOLOGY; BRANCH DAVIDIAN; HUMAN IDENTIFICATION AB Anthropological contributions to the investigation of the events at the Branch Davidian Compound near Waco, Texas in early 1993, were of two major types: the recovery of human remains from the site and the analysis of most of those individuals at the Medical Examiner's Office in Fort Worth, Texas. This paper describes the role of forensic anthropology in the recovery and analysis of Branch Davidian Compound victims and the recovery procedures and characteristics of the victims. C1 FBI LAB,HAIRS & FIBRES UNIT,WASHINGTON,DC. MED EXAMINER PROGRAM,FRANKFORT,KY. USA,CENT IDENTIFICAT LAB,HONOLULU,HI. TARRANT CTY MED EXAMINERS OFF,FT WORTH,TX. RP UBELAKER, DH (reprint author), SMITHSONIAN INST,NATL MUSEUM NAT HIST,DEPT ANTHROPOL,WASHINGTON,DC 20560, USA. NR 2 TC 16 Z9 16 U1 3 U2 12 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAY PY 1995 VL 40 IS 3 BP 335 EP 340 PG 6 WC Medicine, Legal SC Legal Medicine GA RB239 UT WOS:A1995RB23900001 PM 7782737 ER PT J AU OWSLEY, DW UBELAKER, DH HOUCK, MM SANDNESS, KL GRANT, WE CRAIG, EA WOLTANSKI, TJ PEERWANI, N AF OWSLEY, DW UBELAKER, DH HOUCK, MM SANDNESS, KL GRANT, WE CRAIG, EA WOLTANSKI, TJ PEERWANI, N TI THE ROLE OF FORENSIC ANTHROPOLOGY IN THE RECOVERY AND ANALYSIS OF BRANCH-DAVIDIAN COMPOUND VICTIMS - TECHNIQUES OF ANALYSIS SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE PHYSICAL ANTHROPOLOGY; HUMAN IDENTIFICATION; MASS DISASTER; BRANCH DAVIDIANS; COMMINGLED REMAINS; TRAUMA AB The recovery and analysis of human remains from the Branch Davidian Compound, Mount Carmel, Texas, was a multidisciplinary team effort. This presentation deals with one aspect of the forensic anthropological contribution to this collaborative endeavor-the examination and inventory of human skeletal remains and the interpretation of these osteological data. Briefly described first are the content and format of the skeletal inventory and the examination procedures used for data collection. Two subsequent sections illustrate the use of these data to determine (a) age, sex, ancestry, stature, and other distinguishing characteristics, and (b) the presence and nature of any premortem, perimortem, and postmortem trauma. The next section shows how these findings assist in establishing positive identification through, for example, comparison with medical, dental, and other background records, especially comparison of premortem and postmortem radiographs of bones or dentition. In this context, we consider also the sorting of commingled remains, which includes preliminary assessment of rapidly decomposing remains prior to autopsy to preserve information crucial to identification. C1 FBI LAB,WASHINGTON,DC. USA,CENT IDENTIFICAT LAB,HONOLULU,HI. MED EXAMINER PROGRAM,FRANKFORT,KY. TARRANT CTY MED EXAMINERS OFF,FT WORTH,TX. RP OWSLEY, DW (reprint author), SMITHSONIAN INST,NATL MUSEUM NAT HIST,DEPT ANTHROPOL,MAIL STOP 112,WASHINGTON,DC 20560, USA. NR 12 TC 15 Z9 15 U1 2 U2 13 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAY PY 1995 VL 40 IS 3 BP 341 EP 348 PG 8 WC Medicine, Legal SC Legal Medicine GA RB239 UT WOS:A1995RB23900002 PM 7782738 ER PT J AU LITT, J KURTKAYA, M DUYAR, A AF LITT, J KURTKAYA, M DUYAR, A TI SENSOR FAULT-DETECTION AND DIAGNOSIS FOR A T700 TURBOSHAFT ENGINE SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Note C1 OYAK RENAULT AUTOMOBILE CO,RES & DEV,BURSA,TURKEY. FLORIDA ATLANTIC UNIV,DEPT MECH ENGN,BOCA RATON,FL 33431. RP LITT, J (reprint author), NASA,LEWIS RES CTR,VEHICLE PROP DIRECTORATE,ARMY RES LAB,MAIL STOP 77-1,2100 BROOKPARK RD,CLEVELAND,OH 44135, USA. NR 5 TC 3 Z9 3 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD MAY-JUN PY 1995 VL 18 IS 3 BP 640 EP 642 DI 10.2514/3.21439 PG 3 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA QY606 UT WOS:A1995QY60600040 ER PT J AU YEVICH, SJ SANCHEZ, JL DEFRAITES, RF RIVES, CC DAWSON, JE UHAA, IJ JOHNSON, BJB FISHBEIN, DB AF YEVICH, SJ SANCHEZ, JL DEFRAITES, RF RIVES, CC DAWSON, JE UHAA, IJ JOHNSON, BJB FISHBEIN, DB TI SEROEPIDEMIOLOGY OF INFECTIONS DUE TO SPOTTED-FEVER GROUP RICKETTSIAE AND EHRLICHIA SPECIES IN MILITARY PERSONNEL EXPOSED IN AREAS OF THE UNITED-STATES WHERE SUCH INFECTIONS ARE ENDEMIC SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID INDIRECT FLUORESCENT-ANTIBODY; TICK-BORNE INFECTIONS; SEROLOGICAL EVIDENCE; ETIOLOGIC AGENT; PERMETHRIN; PROTECTION; DIAGNOSIS; ARKANSAS; DISEASE; CLUSTER AB A prospective, seroepidemiologic study of spotted fever group rickettsiae (SFGR) and Ehrlichia infections was done among 1194 US military personnel exposed in a heavily tick-infested area of Arkansas in 1990. Seroconversion (4-fold) and seroprevalence rates were determined by indirect immunofluorescent antibody assays. Seroconversions to SFGR occurred in 30 persons (2.5%), whereas seroconversion to Ehrlichia species occurred in 15 (1.3%). The majority of seroconverters did not report symptoms (22/30 [73%] of SFGR seroconverters; 10/15 [67%] of Ehrlichia species seroconverters). History of tick attachment was associated with seroconversion to SFGR (relative risk [RR] = 4.3, P < .001) and Ehrlichia species (RR = 3.6, P < .05). Use of permethrin-impregnated uniforms significantly decreased risk of infection (P < .01); use of bed nets increased risk by 4-fold. Tickborne infections represent a significant threat to military personnel training in areas in which these infections are endemic. C1 WALTER REED ARMY INST RES,DEPT FIELD STUDIES,DIV PREVENT MED,WASHINGTON,DC. CTR DIS CONTROL & PREVENT,CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,ATLANTA,GA. CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV VECTOR BORNE INFECT DIS,MOLEC BIOL BRANCH,FT COLLINS,CO. NR 35 TC 72 Z9 74 U1 1 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY PY 1995 VL 171 IS 5 BP 1266 EP 1273 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA QU640 UT WOS:A1995QU64000027 PM 7751702 ER PT J AU GOLENDA, CF KLEIN, T COLEMAN, R BURGE, R WARD, RA SEELEY, DC AF GOLENDA, CF KLEIN, T COLEMAN, R BURGE, R WARD, RA SEELEY, DC TI DEPLETION OF TOTAL SALIVARY-GLAND PROTEIN IN BLOOD-FED ANOPHELES MOSQUITOS SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ANOPHELES; BLOODFEEDING; SALIVARY GLANDS ID AEDES-AEGYPTI MOSQUITOS; MALARIA SPOROZOITES; PLASMODIUM-FALCIPARUM; TRANSMISSION; STEPHENSI; QUANTITATION; CULICIDAE; DIPTERA; TIME AB Reduction in total salivary gland protein from four anopheline vectors of human malaria, Anopheles stephensi Listen, An. albimanus Wiedmann, An. gambiae Giles, and An. freeborni Aitken, was quantified after mosquitoes blood-fed to repletion on human volunteers, hamsters or through a Baudruche artificial membrane. Total salivary gland protein from pools of six unfed mosquitoes ranged from 4.33 to 7.91 mu g/ml. The difference between the total protein of glands from unfed and blood-fed mosquitoes for all species ranged from 1.77 to 3.12 (mu g/ml for six pooled salivary glands. Total salivary gland protein for mosquitoes blood-fed to repletion was significantly less than that of unfed controls from the same cohort. Reduction in total salivary gland protein for An. freeborni and An stephensi blood fed to repletion on human volunteers, hamsters, and a Baudruche membrane ranged from 24 to 46%, from 43 to 56%, and from 24 to 51%, respectively An. stephensi mosquitoes were allowed to blood feed on humans for 0 (unfed), 0.5-, 1.0-, 2.0-min time periods or to repletion (>2-5 min). As feeding time increased, there was a significant decrease in total amount of protein in the salivary glands. This decrease was proportional over time, indicating that salivation occurred continuously from the beginning (probing) of blood feeding to withdrawal of the mosquito mouthparts at repletion. These data indicate that during blood feeding there was no apparent difference between species in the salivary gland output measured as amount of protein depleted from the salivary glands and that depletion of salivary protein from the glands occurred continuously as mosquitoes fed to repletion. C1 WALTER REED ARMY INST RES,DEPT BIOMETR,WASHINGTON,DC 20307. RP GOLENDA, CF (reprint author), WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 25 TC 11 Z9 13 U1 0 U2 2 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1995 VL 32 IS 3 BP 300 EP 305 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA QW429 UT WOS:A1995QW42900012 PM 7616520 ER PT J AU PERICH, MJ STRICKMAN, D WIRTZ, RA STOCKWELL, SA GLICK, JI BURGE, R HUNT, G LAWYER, PG AF PERICH, MJ STRICKMAN, D WIRTZ, RA STOCKWELL, SA GLICK, JI BURGE, R HUNT, G LAWYER, PG TI FIELD-EVALUATION OF 4 REPELLENTS AGAINST LEPTOCONOPS-AMERICANUS (DIPTERA, CERATOPOGONIDAE) BITING MIDGES SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE LEPTOCONOPS AMERICANUS; BITING MIDGES; REPELLENT AB Four repellents, deet, AI3-37220, AI3-35765, and CIC-4, prepared as 12.5% ethanol solutions, were evaluated against biting midges on Stansbury Islands, UT. Leptoconops americanus Carter was the only species that was biting human volunteers during the study. This species bit primarily on the ears at rates up to 840 bites per hour. All four repellents significantly reduced the number of bites on treated volunteers. AI3-37220 consistently provided the longest period of protection, giving 97 and 74% protection at 4 and 8 h, respectively. In a direct statistical comparison, AI3-37220 significantly outperformed deet. CIC-4 and AI3-35765 were the least effective repellents, providing 45-78 protection 8 h after application. RP PERICH, MJ (reprint author), WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 8 TC 19 Z9 20 U1 0 U2 3 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1995 VL 32 IS 3 BP 306 EP 309 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA QW429 UT WOS:A1995QW42900013 PM 7616521 ER PT J AU MILLARD, CB BROOMFIELD, CA AF MILLARD, CB BROOMFIELD, CA TI ANTICHOLINESTERASES - MEDICAL APPLICATIONS OF NEUROCHEMICAL PRINCIPLES SO JOURNAL OF NEUROCHEMISTRY LA English DT Review DE CHOLINESTERASE; ORGANOPHOSPHORUS; CARBAMATES ID INDUCED DELAYED NEUROTOXICITY; ALZHEIMERS-DISEASE; MOLECULAR-FORMS; NERVE AGENTS; PLASMA BUTYRYLCHOLINESTERASE; HUMAN ACETYLCHOLINESTERASE; CHOLINERGIC SENSITIVITY; INTERMEDIATE SYNDROME; SENILE DEMENTIA; ANIONIC SITE AB Cholinesterases form a family of serine esterases that arise in animals from at least two distinct genes. Multiple forms of these enzymes can be precisely local localized and regulated by alternative mRNA splicing and by co- or posttranstational modifications. The high catalytic efficiency of the cholinesterases is quelled by certain very selective reversible and irreversible inhibitors. Owing largely to the important role of acetylcholine hydrolysis in neurotransmission, cholinesterase and its inhibitors have been studied extensively in vivo. in parallel, there has emerged an equally impressive enzyme chemistry literature. Cholinesterase inhibitors are used widely as pesticides; in this regard the compounds are beneficial with concomitant health risks. Poisoning by such compounds can result in an acute but usually manageable medical crisis and may damage the CNS and the PNS, as well as cardiac and skeletal muscle tissue. Some inhibitors have been useful for the treatment of glaucoma and myasthenia gravis, and others are in clinical trials as therapy for Alzheimer's dementia. Concurrently, the most potent inhibitors have been developed as highly toxic chemical warfare agents. We review treatments and sequelae of exposure to selected anticholinesterases, especially organophosphorus compounds and carbamates, as they relate to recent progress in enzyme chemistry. RP USA, MED RES INST CHEM DEF, ATTN MCMR UV PB, ABERDEEN PROVING GROUND, MD 21010 USA. NR 170 TC 99 Z9 102 U1 3 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3042 EI 1471-4159 J9 J NEUROCHEM JI J. Neurochem. PD MAY PY 1995 VL 64 IS 5 BP 1909 EP 1918 PG 10 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA QU384 UT WOS:A1995QU38400001 PM 7722478 ER EF