FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Carlson, JW Fowler, JM Mitchell, SK Carson, LF Mayer, AR Copeland, LJ AF Carlson, JW Fowler, JM Mitchell, SK Carson, LF Mayer, AR Copeland, LJ TI Chemoprophylaxis with ciprofloxacin in ovarian cancer patients receiving paclitaxel: A randomized trial SO GYNECOLOGIC ONCOLOGY LA English DT Article ID TRIMETHOPRIM-SULFAMETHOXAZOLE PROPHYLAXIS; ACUTE-LEUKEMIA; NEUTROPENIC PATIENTS; INFECTION PROPHYLAXIS; TAXOL PACLITAXEL; PREVENTION; BACTEREMIA; AGENTS; FEVER AB The objective of this study was to evaluate the efficacy of oral ciprofloxacin in preventing febrile morbidity superimposed on the neutropenia induced from a paclitaxel regimen in ovarian cancer patients. Eligible patients received paclitaxel at doses of 135 to 175 mg/m(2) alone or in combination with a platinum agent. They were randomized to either an observation (control) group or a ciprofloxacin prophylaxis group. Patients in the ciprofloxacin group received 500 mg ciprofloxacin orally twice a day once the absolute neutrophil count (ANC) was less than 500/mm(3) and continued until the ANC was greater than 1000/mm(3). Ninety patients were enrolled between the control (n=45) and ciprofloxacin (n=45) groups. They received 371 cycles of a paclitaxel-based regimen with 177 and 194 cycles in the control and ciprofloxacin groups, respectively. Ciprofloxacin prophylaxis was prescribed for 138 (71%) of the cycles in the ciprofloxacin group and was given for a mean duration of 7.7 days per cycle. The groups were similar in disease status and risk factors for neutropenia. Fifteen patients in the central group developed febrile neutropenia versus 12 of those in the ciprofloxacin group (P=0.69). The mean ANC and mean length of hospital stay for neutropenic fever were also similar between groups, There was a greater frequency of an ANC <100 associated with those prophylaxed with ciprofloxacin (P=0.01). Only 44% of the febrile episodes were associated with a positive culture. Staphylococcus aureus was the most frequently reported organism isolated. Considering these results, it does not appear that febrile neutropenia is reduced by ciprofloxacin during grade IV neutropenia. (C) 1997 Academic Press. C1 UNIV MINNESOTA,MINNEAPOLIS,MN 55455. WALTER REED ARMY MED CTR,WASHINGTON,DC 20012. OHIO STATE UNIV,COLUMBUS,OH 43210. RP Carlson, JW (reprint author), WILLIAM BEAUMONT ARMY MED CTR,EL PASO,TX 79920, USA. NR 21 TC 15 Z9 15 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAY PY 1997 VL 65 IS 2 BP 325 EP 329 DI 10.1006/gyno.1997.4630 PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA WZ671 UT WOS:A1997WZ67100023 PM 9159346 ER PT J AU Hall, KL Teneriello, MG Taylor, RR Lemon, S Ebina, M Linnoila, RI Norris, H Park, RC Birrer, MJ AF Hall, KL Teneriello, MG Taylor, RR Lemon, S Ebina, M Linnoila, RI Norris, H Park, RC Birrer, MJ TI Analysis of Ki-ras, p53, and MDM2 genes in uterine leiomyomas and leiomyosarcomas SO GYNECOLOGIC ONCOLOGY LA English DT Article ID TUMOR-SUPPRESSOR GENE; SMOOTH-MUSCLE TUMORS; CELL LUNG-CANCER; MUTATIONS; OVEREXPRESSION; SARCOMAS; PROTEIN AB Uterine sarcomas are unusual neoplasms of the female genital tract whose molecular etiology is largely unknown. We examined 20 leiomyomas as well as 23 uterine leiomyosarcomas for the presence of mutations in the Ki-ras and p53 genes, and overexpression of the MDM2 gene. Codons 12, 13, and 61 from the Ki-ras gene were characterized for the presence of mutations by restriction enzyme polymorphisms using mismatched primers and nucleic acid sequencing as appropriate, Activated Ki-ras genes were identified in 3/20 leiomyomas and 0/23 leiomyosarcomas. The p53 gene was analyzed by SSCP, nucleic acid sequencing, and immunohistochemical staining, None of 20 leiomyomas and 6/23 leiomyosarcomas exhibited p53 abnormalities. The SSCP/sequencing results did not consistently correlate with the IHC staining. MDM2 overexpression occurred in 0/20 leiomyomas and 3/23 sarcomas. Clinical correlation suggested that tumors with p53 mutations have a higher histologic grade or stage at presentation, We conclude that leiomyomas and leiomyosarcomas have different patterns of molecular alterations and are separate biologic entities. In addition, p53 and MDM2 overexpression may play a role in the development of a subset of leiomyosarcomas. (C) 1997 Academic Press. C1 NCI, BIOMARKERS & PREVENT RES BRANCH, DIV CLIN SCI, ROCKVILLE, MD 20850 USA. BROOKE ARMY MED CTR, DEPT OBSTET & GYNECOL GYNECOL ONCOL, FT SAM HOUSTON, TX 78234 USA. NATL NAVAL MED CTR, BETHESDA, MD 20889 USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NR 20 TC 56 Z9 58 U1 0 U2 4 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAY PY 1997 VL 65 IS 2 BP 330 EP 335 DI 10.1006/gyno.1997.4653 PG 6 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA WZ671 UT WOS:A1997WZ67100024 PM 9159347 ER PT J AU Fucile, E Borghese, F Denti, P Saija, R Sindoni, OI AF Fucile, E Borghese, F Denti, P Saija, R Sindoni, OI TI General reflection rule for electromagnetic multipole fields on a plane interface SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE electromagnetic reflection; multipole fields ID EXACT-IMAGE THEORY; HALF-SPACE PROBLEM; LIGHT-SCATTERING; SPHERE; FORMULATION; SUBSTRATE; DIPOLE AB The general rule for reflection of a vector 2'-pole field on a plane interface between two media of different dielectric properties is established starting from the expansion of the spherical multipole field as a linear combination of inhomogeneous vector plane waves, In fact, by considering vector multipole fields that satisfy the radiation condition at infinity we are able to define a matrix that effects their reflection on the plane interface, Such a matrix can also be used to reflect a superposition of many 2'-pole fields and so can be useful to describe the effect of a plane surface near to a specified source or to a scattering particle. C1 UNIV MESSINA,DIPARTIMENTO FIS MAT & TECNOL FIS AVANZATE,I-98166 MESSINA,ITALY. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP Fucile, E (reprint author), CTR SICILIANO RIC ATMOSFER & FIS AMBIENTE,I-98166 MESSINA,ITALY. NR 16 TC 18 Z9 18 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD MAY PY 1997 VL 45 IS 5 BP 868 EP 875 DI 10.1109/8.575639 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA WW909 UT WOS:A1997WW90900015 ER PT J AU Vitebskiy, S Carin, L Ressler, MA Le, FH AF Vitebskiy, S Carin, L Ressler, MA Le, FH TI Ultra-wideband, short-pulse ground-penetrating radar: Simulation and measurement SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article ID TRANSIENT-RESPONSE; EXTRACTING POLES; HALF-SPACE; SCATTERING; RESONANCES; PARAMETERS; BODIES; SYSTEM; LOSSY AB Ultra-wideband (UWB), short-pulse (SP) radar is investigated theoretically and experimentally for the detection and identification of targets buried in and placed atop soil. The calculations are performed using a rigorous, three-dimensional (3-D) Method of Moments algorithm for perfectly conducting bodies of revolution. Particular targets investigated theoretically include anti-personnel mines, anti-tank mines, and a 55-gallon drum, for which we model the time-domain scattered fields and the buried-target late-time resonant frequencies. With regard to the latter, the computed resonant frequencies are utilized to assess the feasibility of resonance-based buried-target identification for this class of targets, The measurements are performed using a novel UWB, SP synthetic aperture radar (SAR) implemented on a mobile boom. Experimental and theoretical results are compared. C1 USA,RES LAB,AMSRL,SE,RU,ADELPHI,MD 20783. RP Vitebskiy, S (reprint author), DUKE UNIV,DEPT ELECT & COMP ENGN,DURHAM,NC 27708, USA. NR 40 TC 99 Z9 108 U1 3 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD MAY PY 1997 VL 35 IS 3 BP 762 EP 772 DI 10.1109/36.581999 PG 11 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA WZ433 UT WOS:A1997WZ43300026 ER PT J AU Wu, YW Chang, SC AF Wu, YW Chang, SC TI Coding scheme for synchronous-CDMA systems SO IEEE TRANSACTIONS ON INFORMATION THEORY LA English DT Letter DE CDMA; multiaccess communications AB This correspondence presents a new coding scheme based on a combinatory detecting set for synchronous code-division multiple-access (S-CDMA) systems, which can support a number of users far exceeding current S-CDMA approaches. Examples of code construction and decoding are also given. C1 GEORGE MASON UNIV,DEPT ELECT & COMP ENGN,FAIRFAX,VA 22030. RP Wu, YW (reprint author), USA,CECOM RDEC,AMSEL RD IEW TRI,VINT HILL FARMS STN,INTELLIGENCE & ELECT WARFARE DIRECTORATE,WARRENTON,VA 22186, USA. NR 6 TC 8 Z9 8 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9448 J9 IEEE T INFORM THEORY JI IEEE Trans. Inf. Theory PD MAY PY 1997 VL 43 IS 3 BP 1064 EP 1067 DI 10.1109/18.568721 PG 4 WC Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA WV233 UT WOS:A1997WV23300031 ER PT J AU Rhodes, DL Perlman, BS AF Rhodes, DL Perlman, BS TI Parallel computation for microwave circuit simulation SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article DE harmonic balance; parallel simulation AB In this paper, the results of implementing a harmonic balance simulator, AGILE, on a variety of massively parallel computers (MPC's) is given. Descriptions of the computer hardware, which includes both shared-memory and message-passing implementations, and algorithms used to parallelize the computations are presented. The computers used include the CM-5, KSR-1, and a networked set of nonheterogeneous workstations using UNIX RPC. A key aspect is the description of the variety of algorithms used for each computer and the results obtained. RP Rhodes, DL (reprint author), USA,RES LAB,SENSORS & ELECT DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 11 TC 4 Z9 4 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD MAY PY 1997 VL 45 IS 5 BP 587 EP 592 DI 10.1109/22.575573 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA WY199 UT WOS:A1997WY19900003 ER PT J AU Nuteson, TW Hwang, HS Steer, MB Naishadham, K Harvey, J Mink, JW AF Nuteson, TW Hwang, HS Steer, MB Naishadham, K Harvey, J Mink, JW TI Analysis of finite grid structures with lenses in quasi-optical systems SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article DE Green's function; moment methods ID IMPEDANCE AB A full-wave moment-method technique developed for the analysis of quasi-optical (QO) systems is used to model finite grid structures in a lens system. This technique incorporates an electric-field dyadic Green's function for a grid centered between two lenses. This is derived by separately considering paraxial and nonparaxial fields. Results for the driving point reflection coefficient of a 3 x 3 and 5 x 5 grid in the lens system are computed and compared with measurements. C1 WRIGHT STATE UNIV, DEPT ELECT ENGN, DAYTON, OH 45435 USA. USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP Nuteson, TW (reprint author), N CAROLINA STATE UNIV, DEPT ELECT & COMP ENGN, ELECT RES LAB, RALEIGH, NC 27695 USA. NR 8 TC 8 Z9 8 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD MAY PY 1997 VL 45 IS 5 BP 666 EP 672 DI 10.1109/22.575583 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA WY199 UT WOS:A1997WY19900013 ER PT J AU Sciuto, AM AF Sciuto, AM TI Ibuprofen treatment enhances the survival of mice following exposure to phosgene SO INHALATION TOXICOLOGY LA English DT Article ID INDUCED PULMONARY-EDEMA; LUNG INJURY; ENDOTOXIC-SHOCK; RAT LUNG; INHALATION; INVITRO; IRON AB The present study was designed to investigate the efficacy of ibuprofen (IBU) administered after a lethal dose of phosgene. Mice were exposed to 32 mg/m(3) phosgene for 20 min and immediately injected with IBU (0, 3, 9, or 15 mg/mouse, ip). Five hours later, a second IBU injection was given but at half the original doses (0, 1.5, 4.5, and 7.5 mg/mouse). These are referred to throughout as the 0/0, 3/1.5, 9/4.5, and 15/7.5 mg IBU/mouse groups. Survival in these groups was determined at 12 and 24 h. In mice that died within 12 h, the lungs were removed, and lung wet weights, dry weights, wet/dry weight ratios, malondialdedyde (MDA), and nonprotein sulfhydryls (NPSH) were measured. Survival odds ratios were calculated for each dose at 12 and 24 h. The 12-h survival was 63% for 9/4.5 mg IBU and 82% for the 15/7.5 mg IBU group compared with 25% for saline-treated mice. At 24 h, survival rates were reduced to 19%, 19%, and 6%, respectively. In the 15/7.5 mg IBU group, dry weights, wet/dry weight ratios, and wet weights were significantly lower than in saline-treated mice at 12 h. MDA war lower only for the 9/4.5 mg IBU dose; however, NPSHs were greater across all IBU doses. The survival odds ratio was 5 for the 9/4.5 IBU group at 12 h and 13 for the 15/7.5 mg IBU group compared with 3.5 for both groups at 24 h. Therefore, IBU treatment increased the survival of mice at 12 h by reducing edema formation, lipid peroxidation, and glutathione depletion. C1 USA,MED RES INST CHEM DEF,DIV PHARMACOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 41 TC 12 Z9 12 U1 1 U2 1 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0895-8378 J9 INHAL TOXICOL JI Inhal. Toxicol. PD MAY PY 1997 VL 9 IS 4 BP 389 EP 403 DI 10.1080/089583797198204 PG 15 WC Toxicology SC Toxicology GA XA711 UT WOS:A1997XA71100005 ER PT J AU Cannella, DA Sohn, SY Pate, C AF Cannella, DA Sohn, SY Pate, C TI Evaluating new weapon systems technology: The javelin versus the dragon SO INTERFACES LA English DT Article AB To achieve its missions, the US Army needs to take advantage of improvements in weapons technology. To replace the medium antiarmor Dragon weapon system, the army is testing a new system called Javelin. We used simulation to explore Javelin's potential to enhance the effectiveness of the mechanized infantry. We developed scenarios employing the Janus(A) high-resolution combat model. These scenarios represent force-on-force trials of mechanized versus fully modernized armor heavy threats in deliberate defense and movement-to-contact missions. Our results indicate that the Javelin performs better than the Dragon in mechanized force. These findings and related study results led to the US Army's decision to replace the Dragon with the Javelin in its mechanized infantry units. C1 USA,TRADOC ANAL COMMAND,MONTEREY,CA 93943. YONSEI UNIV,DEPT IND SYST ENGN,SEOUL 120749,SOUTH KOREA. RP Cannella, DA (reprint author), TRANSPORTAT ENGN AGCY,MIL TRAFF MANAGEMENT COMMAND,DEPLOYABILITY ANAL DIV,NEWPORT NEWS,VA 23606, USA. RI Sohn, So Young/G-8043-2012 NR 16 TC 1 Z9 1 U1 0 U2 1 PU INST OPERATIONS RESEARCH MANAGEMENT SCIENCES PI LINTHICUM HTS PA 901 ELKRIDGE LANDING RD, STE 400, LINTHICUM HTS, MD 21090-2909 SN 0092-2102 J9 INTERFACES JI Interfaces PD MAY-JUN PY 1997 VL 27 IS 3 BP 29 EP 38 DI 10.1287/inte.27.3.29 PG 10 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA XG989 UT WOS:A1997XG98900004 ER PT J AU Crane, CC AF Crane, CC TI Blankets of fire: US bombers over Japan during World War II - Werrell,KP SO INTERNATIONAL HISTORY REVIEW LA English DT Book Review RP Crane, CC (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SIMON FRASER UNIV, INT HISTORY REVIEW PI BURNABY PA EAA 2015, BURNABY BC V5A 1S6, CANADA SN 0707-5332 J9 INT HIST REV JI Int. Hist. Rev. PD MAY PY 1997 VL 19 IS 2 BP 426 EP 428 PG 3 WC History SC History GA XA044 UT WOS:A1997XA04400044 ER PT J AU Hamburger, KE AF Hamburger, KE TI An American dilemma: Vietnam, 1964-1973 - Showalter,DE SO INTERNATIONAL HISTORY REVIEW LA English DT Book Review RP Hamburger, KE (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SIMON FRASER UNIV, INT HISTORY REVIEW PI BURNABY PA EAA 2015, BURNABY BC V5A 1S6, CANADA SN 0707-5332 J9 INT HIST REV JI Int. Hist. Rev. PD MAY PY 1997 VL 19 IS 2 BP 450 EP 453 PG 4 WC History SC History GA XA044 UT WOS:A1997XA04400060 ER PT J AU Hamburger, KE AF Hamburger, KE TI China's road to the Korean War: The making of the Sino-American confrontation - Chen,J SO INTERNATIONAL HISTORY REVIEW LA English DT Book Review RP Hamburger, KE (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SIMON FRASER UNIV, INT HISTORY REVIEW PI BURNABY PA EAA 2015, BURNABY BC V5A 1S6, CANADA SN 0707-5332 J9 INT HIST REV JI Int. Hist. Rev. PD MAY PY 1997 VL 19 IS 2 BP 450 EP 453 PG 4 WC History SC History GA XA044 UT WOS:A1997XA04400059 ER PT J AU Hoskins, WJ McGuire, WP Brady, MF Kucera, PR Partridge, EE Look, KY ClarkePearson, DL Davidson, M AF Hoskins, WJ McGuire, WP Brady, MF Kucera, PR Partridge, EE Look, KY ClarkePearson, DL Davidson, M TI Combination paclitaxel (Taxol(R))-cisplatin vs cyclophosphamide-cisplatin as primary therapy in patients with suboptimally debulked advanced ovarian cancer SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER LA English DT Article DE ovarian cancer; paclitaxel-cisplatin; paclitaxel-cyclophosphamide AB The Gynecologic Oncology Group initiated a study to evaluate combination paclitaxel (Taxol(R), Bristol-Myers Squibb Company)-cisplatin vs standard therapy with cyclophosphamide-cisplatin as primary therapy for patients with suboptimally debulked advanced ovarian cancer. The 386 eligible patients were randomly assigned to treatment with either cisplatin 75 mg m(-2) plus cyclophosphamide 750 mg m(-2) or the same dose of cisplatin plus paclitaxel 135 mg m(-2) given over 24 h. Response to therapy was assessed in 216 patients with clinically measurable disease. In the standard-therapy arm, overall response was 60%, with a 31% rate of complete response. In the paclitaxel-based treatment group, the overall response was 73%, and 51% of patients achieved a complete response. Although neutropenia, fever, alopecia, and peripheral neuropathy were more common in the paclitaxel-treated patients, myelosuppression was generally brief and nonhematologic toxicities were mild. Both overall and progression-free survival significantly favored patients treated with paclitaxel-cisplatin: overall survival was 37.5 vs 24.4 months, and progression-free survival was 17.9 vs 12.9 months for the paclitaxel- and cyclophosphamide-treated groups, respectively. Paclitaxel-cisplatin offers prolonged survival and progression-free survival without increasing toxicity when used as first-line therapy for patients with suboptimally debulked ovarian cancer. C1 CORNELL UNIV,COLL MED,DEPT OBSTET & GYNECOL,NEW YORK,NY. EMORY UNIV,DEPT MED,ATLANTA,GA 30322. ROSWELL PK CANC CTR,STAT OFF,GYNECOL ONCOL GRP,BUFFALO,NY. OREGON HLTH SCI UNIV,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,PORTLAND,OR 97201. UNIV ALABAMA,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,BIRMINGHAM,AL 35294. INDIANA UNIV,SCH MED,DIV OBSTET & GYNECOL,INDIANAPOLIS,IN. DUKE UNIV,SCH MED,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,DURHAM,NC 27706. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,AREA LAB SCI,WASHINGTON,DC 20307. RP Hoskins, WJ (reprint author), MEM SLOAN KETTERING CANC CTR,DEPT SURG,GYNECOL SERV,1275 YORK AVE,NEW YORK,NY 10021, USA. NR 5 TC 5 Z9 5 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 SN 1048-891X J9 INT J GYNECOL CANCER JI Int. J. Gynecol. Cancer PD MAY-JUN PY 1997 VL 7 SU 1 BP 9 EP 13 DI 10.1046/j.1525-1438.7.s1.5.x PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA XP016 UT WOS:A1997XP01600003 ER PT J AU Shoop, BL Ressler, EK Sayles, AH Hall, DA AF Shoop, BL Ressler, EK Sayles, AH Hall, DA TI A smart pixel implementation of an error diffusion neural network for digital halftoning SO INTERNATIONAL JOURNAL OF OPTOELECTRONICS LA English DT Article ID A/D CONVERSION; EFFECT DEVICES; NOISE; MODEL AB A novel approach to digital image halftoning is proposed based on a symmetric error diffusion algorithm, a new form of artificial neural network, and a CMOS-SEED smart pixel hardware implementation. Using an error diffusion neural network, all pixel quantization decisions are computed in parallel and therefore fully-symmetric error diffusion can be accomplished. Visual artefacts such as directional hysteresis and transient behaviour near boundaries, which have become characteristic of classical unidirectional error diffusion techniques, are virtually eliminated. The smart pixel implementation provides the speed and parallelism necessary to provide a real-time halftoning capability. RP Shoop, BL (reprint author), US MIL ACAD, PHOTON RES CTR, DEPT ELECT ENGN & COMP SCI, W POINT, NY 10996 USA. NR 26 TC 15 Z9 15 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0952-5432 J9 INT J OPTOELECTRON JI Int. J. Optoelectron. PD MAY-JUN PY 1997 VL 11 IS 3 BP 217 EP 228 PG 12 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA YG212 UT WOS:A1997YG21200006 ER PT J AU Montgomery, JS Wells, MGH Roopchand, B Ogilvy, JW AF Montgomery, JS Wells, MGH Roopchand, B Ogilvy, JW TI Low-cost titanium armors for combat vehicles SO JOM-JOURNAL OF THE MINERALS METALS & MATERIALS SOCIETY LA English DT Article AB The U.S. Army has been using more and more titanium to either increase armor or reduce the weight of current combat vehicles. Future plans call for the development of combat vehicles that are 30 percent lighter. To achieve this target, the future-vehicle hull and turret will have to be manufactured using move ballistically efficient materials than rolled homogeneous steel armor. Low-cost titanium, with its good mechanical, ballistic, and corrosion properties and acceptable fabricability, offers the overall best alternative to achieving this objective. C1 USA,TACOM,TARDEC,ABERDEEN PROVING GROUND,MD 21005. RP Montgomery, JS (reprint author), USA,AMSRL WM ME,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 7 TC 23 Z9 23 U1 2 U2 6 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 1047-4838 J9 JOM-J MIN MET MAT S JI JOM-J. Miner. Met. Mater. Soc. PD MAY PY 1997 VL 49 IS 5 BP 45 EP 47 DI 10.1007/BF02914684 PG 3 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA WX315 UT WOS:A1997WX31500013 ER PT J AU Rodriguez, RJ Dayhoff, DE Chang, G Cassol, SA Birx, DL Artenstein, AW Michael, NL AF Rodriguez, RJ Dayhoff, DE Chang, G Cassol, SA Birx, DL Artenstein, AW Michael, NL TI Comparison of serum and plasma viral RNA measurements in primary and chronic human immunodeficiency virus type 1 infection SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HIV-1; viral load; seroconversion; disease progression; RNA; polymerase chain reaction ID POLYMERASE CHAIN-REACTION; DISEASE PROGRESSION; NATURAL-HISTORY; HIV-1 INFECTION; LYMPHOCYTES; INDIVIDUALS; EXPRESSION; VIREMIA; LOAD AB We sought to define the relation between serum and plasma HIV-1 viral RNA load in patients with primary and chronic HIV-1 disease. HIV-1 viral load was determined from 116 serum and plasma samples, including 33 matched pairs, from five patients with primary and three patients with chronic HIV disease using the Roche HIV Monitor assay, The mean +/- standard deviations of the serum and plasma viral RNA levels from the 33 matched pairs were 4.372 +/- 0.885 and 4.478 +/- 0.950 log10 (copies/ml), respectively. This -0.106 log difference between serum and plasma viral RNA levels, which equates to 21% of non-log-transformed values, was not statistically significant by the Wilcoxon sign rank test (p = 0.09). The distributions of serum and plasma viral load slopes, calculated from all available viral RNA load data for each patient, were also not statistically different (p = 0.07). The levels of HIV-l RNA measured in the serum or plasma of HIV-seropositive patients yield equivalent biologic information. C1 WALTER REED ARMY MED CTR,DIV ALLERGY & IMMUNOL,WASHINGTON,DC 20307. HENRY M JACKSON FDN,ROCKVILLE,MD. BRITISH COLUMBIA CTR EXCELLENCE HIV AIDS,VANCOUVER,BC,CANADA. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. NR 17 TC 17 Z9 17 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD MAY 1 PY 1997 VL 15 IS 1 BP 49 EP 53 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA XH946 UT WOS:A1997XH94600008 PM 9215654 ER PT J AU Lee, DT Toner, MM McArdle, WD Vrabas, IS Pandolf, KB AF Lee, DT Toner, MM McArdle, WD Vrabas, IS Pandolf, KB TI Thermal and metabolic responses to cold-water immersion at knee, hip, and shoulder levels SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE thermoregulation; core temperature; heat flow; heat production; rest; exercise; humans ID EXERCISING MEN; LEG EXERCISE; TEMPERATURE; WOMEN; ADJUSTMENT; INTENSITY; EXPOSURE AB To examine the effect of cold-water immersion at different depths on thermal and metabolic responses, eight men (25 yr old, 16% body fat) attempted 12 tests: immersed to the knee (K), hip (H), and shoulder (Sh) in 15 and 25 degrees C water during both rest (R) or leg cycling [35% peak oxygen uptake; (E)] for up to 135 min. At 15 degrees C, rectal (T-re) and esophageal temperatures (T-es) between R and E were not different in Sh and H groups (P > 0.05), whereas both in K group were higher during E than R (P < 0.05). At 25 degrees C, T-re was higher (P < 0.05) during E than R at all depths, whereas T-es during E was higher than during R in H and K groups. T-re remained at control levels in K-E at 15 degrees C, K-E at 25 degrees C, and in H-E groups at 25 degrees C, whereas T-es remained unchanged in K-E at 15 degrees C, in K-R at 15 degrees C, and in all 25 degrees C conditions (P > 0.05). During R and E, the magnitude of T-re change was greater (P > 0.05) than the magnitude of T-es change in Sh and H groups, whereas it was not different in the K group (P > 0.05). Total heat flow was progressive with water depth. During R at 15 and 25 degrees C, heat production was not increased in K and H groups from control level (P > 0.05) but it did increase in Sh group (P < 0.05). The increase in heat production during E compared with R was smaller (P < 0.05) in Sh (121 +/- 7 W/m(2) at 15 degrees C and 97 +/- 6 W/m(2) at 25 degrees C) than in H (156 +/- 6 and 126 5 W/m(2), respectively) and K groups (155 +/- 4 and 165 +/- 6 W/m(2), respectively). These data suggest that T-re and T-es respond differently during partial cold-water immersion In addition, water levels above knee in 15 degrees C and above hip in 25 degrees C cause depression of internal temperatures mainly due to insufficient heat production offsetting heat loss even during light exercise. C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. CUNY QUEENS COLL,DEPT FAMILY NUTR & EXERCISE SCI,FLUSHING,NY 11367. NR 31 TC 20 Z9 21 U1 1 U2 8 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAY PY 1997 VL 82 IS 5 BP 1523 EP 1530 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA WX868 UT WOS:A1997WX86800021 PM 9134902 ER PT J AU Shitzer, A Stroschein, LA Vital, P Gonzalez, RR Pandolf, KB AF Shitzer, A Stroschein, LA Vital, P Gonzalez, RR Pandolf, KB TI Numerical analysis of an extremity in a cold environment including countercurrent arterio-venous heat exchange SO JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article AB A model of the thermal behavior of an extremity, e.g., a finger, is presented. The model includes the effects of heat conduction, metabolic heat generation, heat transport by blood perfusion, heat exchange between the tissue and the large blood vessels, and arterio-venous heat exchange. Heat exchange with the environment through a layer of thermal insulation, depicting thermal handwear, is also considered. The tissue is subdivided into four concentric layers simulating, from the center outward, core, muscle, fat, and skirt. Differential heat balance equations are formulated for the tissue and for the major artery and the major vein traversing the finger. These coupled equations are solved numerically by a finite-difference, alternating direction method employing a Thomas algorithm. The numerical scheme was extensively tested for its stability and convergence. This paper presents the model equations and results of the convergence tests, and shows plots of blood and tissue temperatures along the axis of the model for combinations of parameters including the effect of countercurrent heat exchange between the artery and the vein. C1 USA, ENVIRONM MED RES INST, ENVIRONM PHYSIOL & MED DIRECTORATE, NATICK, MA 01760 USA. RP TECHNION ISRAEL INST TECHNOL, DEPT MECH ENGN, IL-32000 HAIFA, ISRAEL. NR 25 TC 23 Z9 27 U1 3 U2 12 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0148-0731 EI 1528-8951 J9 J BIOMECH ENG-T ASME JI J. Biomech. Eng.-Trans. ASME PD MAY PY 1997 VL 119 IS 2 BP 179 EP 186 DI 10.1115/1.2796078 PG 8 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA XB151 UT WOS:A1997XB15100007 PM 9168394 ER PT J AU Dalsgaard, A Skov, MN Serichantalergs, O Echeverria, P Meza, R Taylor, DN AF Dalsgaard, A Skov, MN Serichantalergs, O Echeverria, P Meza, R Taylor, DN TI Molecular evolution of Vibrio cholerae O1 strains isolated in Lima, Peru, from 1991 to 1995 SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID FIELD GEL-ELECTROPHORESIS; RESTRICTION PATTERNS; EPIDEMIC CHOLERA; LATIN-AMERICA; EL-TOR; DNA; PLASMID; SEPARATION; RESISTANCE; THAILAND AB Following the emergence of cholera in Lima, Peru, in 1991, isolates of Vibrio cholerae O1 biotype El Tor recovered from patients in various parts of Lima were selected and characterized. Ribotyping and pulsed-field gel electrophoresis (PFGE) revealed four BglI ribotypes and eight NotI PFGE types among 50 V. cholerae O1 strains recovered from patients,vith cholera in Lima from 1991 to 1995, with certain genotypes appearing to cluster geographically. While differences in ribotype and PFGE type patterns suggest that genetic changes are occurring in the strain responsible for the Latin American cholera epidemic, more frequently than previously reported, 40 (80%) O1 strains showed an identical ribotype pattern and 41 (82%) strains showed closely related PFGE types, types 1, 2, or 3, that differed by less than three restriction fragments. All strains were susceptible to nine antibacterial agents studied. In 1991, more than 95% of the clinical V. cholerae O1 strains were serotype Inaba, whereas from 1992, serotype Ogawa began to predominate, with more than 90% of the isolates being of the Ogawa serotype in 1995. The small differences in genotypes of V. cholerae O1 is remarkable because cholera is highly seasonal in coastal areas of Peru and support the hypothesis that the epidemic strain reemerges from an environmental source. However, the relative high rate of genetic changes within V. cholerae O1 as shown by ribotyping and PFGF should be taken into consideration when typing patterns of V. cholerae O1 associated with cholera in Latin America are evaluated. C1 ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. USN,MED RES INST DETACHMENT,DEPT MICROBIOL,LIMA,PERU. USN,MED RES INST DETACHMENT,DEPT MED ECOL,LIMA,PERU. RP Dalsgaard, A (reprint author), ROYAL VET & AGR UNIV,DEPT VET MICROBIOL,13 BULOWSVEJ,DK-1870 FREDERIKSBERG C,DENMARK. NR 33 TC 45 Z9 52 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 1997 VL 35 IS 5 BP 1151 EP 1156 PG 6 WC Microbiology SC Microbiology GA WV178 UT WOS:A1997WV17800021 PM 9114398 ER PT J AU Johnson, MAL Hughes, WC Rowland, WH Cook, JW Schetzina, JF Leonard, M Kong, HS Edmond, JA Zavada, J AF Johnson, MAL Hughes, WC Rowland, WH Cook, JW Schetzina, JF Leonard, M Kong, HS Edmond, JA Zavada, J TI Growth of GaN, InGaN, and AlGaN films and quantum well structures by molecular beam epitaxy SO JOURNAL OF CRYSTAL GROWTH LA English DT Article; Proceedings Paper CT 9th International Conference on Molecular Beam Epitaxy (MBE-IX) CY AUG 05-09, 1996 CL PEPPERDINE UNIV, MALIBU, CA HO PEPPERDINE UNIV ID VAPOR-PHASE EPITAXY AB GaN, AlGaN and InGaN films have been grown by molecular beam epitaxy (MBE) using RF plasma sources for the generation of active nitrogen. These films have been deposited homoepitaxially onto GaN/SiC substrates and heteroepitaxially onto LiGaO2 substrates. LiGaO2 is an ordered and closely-lattice-matched orthorhombic variant of the wurtzite crystal structure of GaN. A low-temperature AlN buffer layer is necessary in order to nucleate GaN on LiGaO2. Thick GaN and AlGaN layers may then be grown once deposition is initiated. InGaN has been grown by MBE at mole fractions of up to 20% as a quantum well between GaN cladding layers. The indium containing structures were deposited onto GaN/SiC substrates to focus the development effort on the InGaN growth process rather than on heteroepitaxial nucleation. A modulated beam technique, with alternating short periods of (In, Ga)N and (Ga)N, was used to grow high-quality InGaN. The modulated beam limits the nucleation of metal droplets on the growth surface, which form due to thermodynamic limitations. A narrow PL dominated by band edge luminescence at 421 nm results from this growth technique. Growth of GaN at high temperatures is also reported. C1 N CAROLINA STATE UNIV, DEPT PHYS, RALEIGH, NC 27695 USA. CREE RES INC, DURHAM, NC 27713 USA. USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. NR 14 TC 37 Z9 39 U1 0 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 EI 1873-5002 J9 J CRYST GROWTH JI J. Cryst. Growth PD MAY PY 1997 VL 175 BP 72 EP 78 DI 10.1016/S0022-0248(96)01019-6 PN 1 PG 7 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA XL451 UT WOS:A1997XL45100013 ER PT J AU MacKenzie, JD Abernathy, CR Pearton, SJ Hommerich, U Wu, X Schwartz, RN Wilson, RG Zavada, JM AF MacKenzie, JD Abernathy, CR Pearton, SJ Hommerich, U Wu, X Schwartz, RN Wilson, RG Zavada, JM TI Er doping of III-nitrides during growth by metalorganic molecular beam epitaxy SO JOURNAL OF CRYSTAL GROWTH LA English DT Article; Proceedings Paper CT 9th International Conference on Molecular Beam Epitaxy (MBE-IX) CY AUG 05-09, 1996 CL PEPPERDINE UNIV, MALIBU, CA HO PEPPERDINE UNIV ID VAPOR-PHASE EPITAXY; ERBIUM; LUMINESCENCE; SILICON; SEMICONDUCTORS AB Solid source Er doping of AlN and GaN during growth by plasma-assisted metalorganic molecular beam epitaxy (MOMBE) with an Er effusion source has resulted in AlN:Er and GaN:Er exhibiting room-temperature 1.54 mu m photoluminescence (PL). The luminescence detected in the AlN:Er samples was orders of magnitude greater in intensity than that from ion-implanted material and represents the first demonstration of strong emission from rare-earth doped, epitaxial III-nitrides doped during growth. The effects of growth temperature on Er incorporation and segregation behavior have also been examined. PL studies, including room temperature and thermal quenching experiments have been conducted showing a reduction in PL intensity of approximately a factor of two between 15 K and room temperature for strongly luminescent AlN:Er. Preliminary results from GaN:Er indicated that thermal quenching is considerably greater in this material than in AlN:Er. C1 HAMPTON UNIV,DEPT PHYS,RES CTR OPT PHYS,HAMPTON,VA 23668. HUGHES RES LABS,MALIBU,CA 90265. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP MacKenzie, JD (reprint author), UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611, USA. NR 14 TC 28 Z9 28 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD MAY PY 1997 VL 175 BP 84 EP 88 DI 10.1016/S0022-0248(96)00925-6 PN 1 PG 5 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA XL451 UT WOS:A1997XL45100015 ER PT J AU Zeng, L Cavus, A Yang, BX Tamargo, MC Bambha, N Gray, A Semendy, F AF Zeng, L Cavus, A Yang, BX Tamargo, MC Bambha, N Gray, A Semendy, F TI Molecular beam epitaxial growth of lattice-matched ZnxCdyMg1-x-ySe quaternaries on InP substrates SO JOURNAL OF CRYSTAL GROWTH LA English DT Article; Proceedings Paper CT 9th International Conference on Molecular Beam Epitaxy (MBE-IX) CY AUG 05-09, 1996 CL PEPPERDINE UNIV, MALIBU, CA HO PEPPERDINE UNIV ID ROOM-TEMPERATURE; LASER AB We report the molecular beam epitaxial (MBE) growth of lattice-matched ZnxCdyMg1-x-ySe quaternaries on InP substrates having a wide range of band gaps. The composition and, thus, band gap and lattice constant, can be accurately controlled by adjusting the group II fluxes. By optimizing the growth condition and incorporating of a III-V buffer layer, we have grown very high-quality quaternary layers. Our best lattice-matched samples exhibit double crystal X-ray rocking curves with full-width-at-half-maximum (FWHM) about 460 arcsec and photoluminescence line widths about 60 meV at 77 K for a band gap of 2.8 eV. These materials can be used for the fabrication of lattice-matched semiconductor lasers that can emit throughout most of the visible range, from yellow to blue. C1 CUNY CITY COLL,DEPT CHEM,NEW YORK,NY 10031. USA,RES LAB,IR OPT TECHNOL OFS,FT BELVOIR,VA 22060. RP Zeng, L (reprint author), CUNY CITY COLL,CUNY CTR ADV TECHNOL PHOTON MAT & APPLICAT,CTR ANAL STRUCT & INTERFACES,NEW YORK,NY 10031, USA. NR 12 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD MAY PY 1997 VL 175 BP 541 EP 545 DI 10.1016/S0022-0248(96)00873-1 PN 1 PG 5 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA XL451 UT WOS:A1997XL45100096 ER PT J AU Cavus, A Zeng, L Yang, BX Dai, N Tamargo, MC Bambha, N Semendy, F AF Cavus, A Zeng, L Yang, BX Dai, N Tamargo, MC Bambha, N Semendy, F TI Optimized growth of lattice-matched ZnCdSe epilayers on InP substrates SO JOURNAL OF CRYSTAL GROWTH LA English DT Article; Proceedings Paper CT 9th International Conference on Molecular Beam Epitaxy (MBE-IX) CY AUG 05-09, 1996 CL PEPPERDINE UNIV, MALIBU, CA HO PEPPERDINE UNIV DE molecular beam epitaxy; II-VI/III-V heteroepitaxy ID GREEN LASER-DIODES; MOLECULAR-BEAM EPITAXY; INJECTION-LASERS; ZNSE; MBE AB Ternaries and quaternaries of ZnCd(Mg)Se can be grown lattice-matched to InP substrates with band gaps spanning most of the visible range. having potential applications as visible light emitters. The quality of these materials is very sensitive to the surface preparation of InP substrates and the initiation of growth, In this paper, we report the details of the growth initiation of ZnCdSe epilayers on InP substrates. The composition of ternary alloy, and thus the lattice-mismatch to InP, was controlled by adjusting the Zn and Cd fluxes. A fast substrate deoxidation, followed by initial low-temperature growth results in two-dimensional growth and substantial improvements of ZnCdSe epilayers, These results along with observations on the use of InGaAs and InP buffer layers indicate that control of the interface chemistry is essential to obtain high-quality materials. C1 CUNY CITY COLL,DEPT CHEM,NEW YORK,NY 10031. USA,RES LAB,IR OPT TECHNOL OFS,FT BELVOIR,VA 22060. RP Cavus, A (reprint author), CUNY CITY COLL,NEW YORK STATE CTR ADV TECHNOL ULTRAFAST PHOTON M,CTR ANAL STRUCT & INTERFACES,NEW YORK,NY 10031, USA. NR 21 TC 5 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD MAY PY 1997 VL 175 BP 558 EP 563 DI 10.1016/S0022-0248(96)01023-8 PN 1 PG 6 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA XL451 UT WOS:A1997XL45100099 ER PT J AU Williams, SC Contreras, M McBiles, M Cawthon, MA Shah, RB AF Williams, SC Contreras, M McBiles, M Cawthon, MA Shah, RB TI The impact of a picture archiving and communication system on nuclear medicine examination interpretation SO JOURNAL OF DIGITAL IMAGING LA English DT Article DE picture archive and communication systems; computers; nuclear medicine ID DIAGNOSTIC-IMAGING INFORMATION; CLINICAL-EXPERIENCE; PACS; UNIVERSITY; ACCESS AB Radiographic correlation is essential for many of the examinations performed in nuclear medicine. The purpose of this study was to evaluate the impact of a picture archiving and communications system (PACS) on the function and efficiency of a nuclear medicine department at a tertiary care institution. We evaluated 250 consecutive noncardiac nuclear medicine imaging examinations and asked the interpreting physician the following questions: (1) Was PACS used in the interpretation of the study? (2) Did the use of PACS expedite examination completion or aid in study interpretation? And (3) Did the use of PACS permit a definitive diagnosis to be made? PACS was accessed for correlative radiographic images in 155 of the 250 (62%) nuclear medicine examinations. Images available on PACS for review aided in study interpretation in 74% (115 of 155) of cases. The use of PACS was thought to expedite examination completion in 55% (86 of 155) of cases, The system was accessed but not operational in only 1% of cases (2 of 155), PACS provides reliable, rapid access to multimodality correlative radiographic images that aid in the interpretation of nuclear medicine examinations, Such systems also increase the efficiency of a nuclear medicine service by allowing timely and conclusive interpretations to be made. Copyright (C) 1997 by W.B. Saunders Company. C1 BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234. RP Williams, SC (reprint author), MADIGAN ARMY MED CTR,DEPT RADIOL,TACOMA,WA 98431, USA. NR 7 TC 8 Z9 8 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0897-1889 J9 J DIGIT IMAGING JI J. Digit. Imaging PD MAY PY 1997 VL 10 IS 2 BP 51 EP 56 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA XA204 UT WOS:A1997XA20400002 PM 9165419 ER PT J AU Shakespeare, RC Donnelly, JC AF Shakespeare, RC Donnelly, JC TI An in vitro comparison of apical microleakage after obturation with JS quick-fill or lateral condensation SO JOURNAL OF ENDODONTICS LA English DT Article ID LEAKAGE AB Thirty extracted human single-root teeth were instrumented to #45 file size while creating a continuous coronal taper, Canals were obturated with Roth 801 sealer and either JS Quick-Fill or lateral condensation of gutta-percha, Mean apical linear microleakage of India Ink was evaluated in cleared teeth using a stereomicroscope. Significantly less leakage (p < 0.1) occurred with lateral condensation than with JS Quick-Fill. C1 ADV EDUC GEN DENT PROGRAM 2 YEAR,FT HOOD,TX. USA,DENT ACTIV,FT HOOD,TX 76544. NR 7 TC 7 Z9 9 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAY PY 1997 VL 23 IS 5 BP 312 EP 314 DI 10.1016/S0099-2399(97)80412-8 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA WW737 UT WOS:A1997WW73700004 PM 9545934 ER PT J AU Johnson, DL Ambrose, SH Bassett, TJ Bowen, ML Crummey, DE Isaacson, JS Johnson, DN AF Johnson, DL Ambrose, SH Bassett, TJ Bowen, ML Crummey, DE Isaacson, JS Johnson, DN TI Meanings of environmental terms SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID SOIL DEGRADATION AB Certain terms and expressions that relate to the environment are problematic in that they vary widely in usage within and between disciplines, and several have been used as synonyms. In an attempt to correct the problem and standardize usage, this paper defines or redefines 10 of the most common environmental terms. Two of these terms, natural environment and environmental change, are defined on the basis of what is meant by natural as reflected by common usage and dictionary entries. The three degradation terms, environmental degradation, land degradation, and soil degradation, are defined as any change or disturbance to the environment, land, or soil perceived to be deleterious or undesirable. A sixth term, soil regeneration, is defined as the reformation of degraded soil through biological, chemical, and/or physical agencies. The remaining four terms, environmental quality, air quality, soil quality, and water quality, are defined as measures of the condition or state of each relative to the requirements of one or more biotic species and/or to any human need or purpose. C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61821. UNIV ILLINOIS,WORLD HERITAGE MUSEUM,URBANA,IL 61801. RP Johnson, DL (reprint author), UNIV ILLINOIS,CTR AFRICAN STUDIES,URBANA,IL 61801, USA. NR 30 TC 51 Z9 53 U1 4 U2 43 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 SN 0047-2425 J9 J ENVIRON QUAL JI J. Environ. Qual. PD MAY-JUN PY 1997 VL 26 IS 3 BP 581 EP 589 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA WZ349 UT WOS:A1997WZ34900009 ER PT J AU Marcuson, WF Hadala, PF Ledbetter, RH AF Marcuson, WF Hadala, PF Ledbetter, RH TI Seismic rehabilitation of earth dams - Closure SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Editorial Material C1 LOUISIANA TECH UNIV,RUSTON,LA 71270. RP Marcuson, WF (reprint author), USA,ENGINEER WATERWAYS EXPT STN,GEOTECH LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD MAY PY 1997 VL 123 IS 5 BP 494 EP 495 DI 10.1061/(ASCE)1090-0241(1997)123:5(494) PG 2 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA WV586 UT WOS:A1997WV58600023 ER PT J AU Geng, ZJ McCullough, CL AF Geng, ZJ McCullough, CL TI Missile control using fuzzy cerebellar model arithmetic computer neural networks SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article AB A novel fuzzy neural network control system architecture, called the fuzzy cerebellar model arithmetic computer (fuzzy CMAC) neural network, is proposed. This fuzzy neural network architecture exploits a synergism between the original CMAC neural network and the theory of fuzzy logic controller The fuzzy CMAC is able to perform arbitrary function approximation and can achieve a higher learning speed and greater accuracy than the original CMAC. It also has the capability of conveniently incorporating human knowledge into the system and processing information based on fuzzy inference rules. We evaluated the use of fuzzy CMAC in the design of advanced missile control systems. The method is demonstrated by missile interception simulations, and promising results are obtained. C1 USA,SPACE & STRATEG DEF COMMAND,SENSOR DIRECTORATE,HUNTSVILLE,AL 35807. RP Geng, ZJ (reprint author), GENEX TECHNOL INC,4950 CLOISTER DR,ROCKVILLE,MD 20850, USA. NR 16 TC 31 Z9 34 U1 0 U2 4 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD MAY-JUN PY 1997 VL 20 IS 3 BP 557 EP 565 DI 10.2514/2.4077 PG 9 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA WY344 UT WOS:A1997WY34400022 ER PT J AU Litvin, AL Kaplan, DL Sung, CM AF Litvin, AL Kaplan, DL Sung, CM TI Microstructure of aragonite grown at an air-liquid interface SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID TEMPERATURE AB Aragonite particles dispersed in a bioresorbable polymer matrix a re considered to be a good candidate for bone prosthesis materials. It is important to characterize the microstructure of synthetic aragonite used for biomedical applications, since the microstructure may influence its integration, resorption and replacement by bone. We studied late stages of aragonite growth, at an air-liquid interface, from a solution not doped with additives. Comparison was made between the types of synthetic aragonite microstructure and that of aragonite which is found in nature (mollusc shells, gallstones, Earth's crust). The microstructure of natural aragonite is unique to certain classes of living organisms and the understanding of its structure/function relationships may help to select the types of synthetic aragonite for specific biomedical applications. Three types of synthetic aragonite were observed based on grain size and grain morphology. C1 GEOCENTERS INC,NATICK,MA 01760. TUFTS UNIV,CTR BIOTECHNOL,MEDFORD,MA 02155. UNIV LOWELL,CTR ADV MAT,LOWELL,MA 01854. RP Litvin, AL (reprint author), USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760, USA. NR 24 TC 4 Z9 4 U1 0 U2 2 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD MAY 1 PY 1997 VL 32 IS 9 BP 2233 EP 2236 DI 10.1023/A:1018511930559 PG 4 WC Materials Science, Multidisciplinary SC Materials Science GA WY350 UT WOS:A1997WY35000001 ER PT J AU Turell, MJ Pollack, RJ Spielman, A AF Turell, MJ Pollack, RJ Spielman, A TI Enema infusion technique inappropriate for evaluating viral competence of ticks SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Amblyomma cajennense ticks; Venezuelan equine encephalitis virus; enema ID EQUINE ENCEPHALOMYELITIS VIRUS; FEVER VIRUS; TRANSMISSION; INFECTION; MOSQUITOS; IXODIDAE; CULEX AB To determine whether anal infusion of virus simulates the natural route of infection rather than intracoelomic injection, we compared the course of Venezuelan equine encephalitis (VEE) virus infection in Amblyomma cajennense (F.) ticks that had been exposed to virus by enema infusion with that in ticks fed on a viremic host or exposed by intracoelomic inoculation. Although virus was detected in virtually all ticks 14 d after exposure, orally exposed ticks contained significantly less virus (10(1.9) plaque-forming units [PFU] per tick) than did ticks infected by enema (10(4.1) PFU per tick) or intracoelomically (10(4.2) PFU per tick). At 42 d after virus exposure, only 1% of 512 orally exposed ticks contained virus, but most enema (77%, n = 43) or intracoelomically (79%, tl = 29) exposed ticks were infected. Replication of VEE virus in A. cajennense ticks exposed to virus by enema infusion, therefore, appeared more similar to that of ticks inoculated intracoelomically than to these exposed orally. Thus, because enema infusion may bypass potential midgut infection and escape barriers, this procedure may not be appropriate for determining vector competence in ixodid ticks. RP Turell, MJ (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,MD 21702, USA. NR 15 TC 3 Z9 4 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1997 VL 34 IS 3 BP 298 EP 300 PG 3 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA WY576 UT WOS:A1997WY57600008 PM 9151493 ER PT J AU Tanskul, P Linthicum, KJ AF Tanskul, P Linthicum, KJ TI A new species of Leptotrombidium (Acari: Trombiculidae) collected in active rice fields in northern Thailand SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Trombiculidae; Leptotrombidium; chiggers; scrub typhus; rodents; rickettsia AB Leptotrombidium (Leptotrombidium) chiangraiensis Tanskul & Linthicum is described and illustrated as new from specimens collected from the rodents Rattus rattus (L., 1758), Rattus argentiventer (Robinson & Kloss, 1916), Rattus losea (Swinhoe, 1870), and Bandicota indica (Bechstein, 1800) in Chiangrai Province, northern Thailand. The new species was collected in active rice fields and adjacent fruit plantation areas. The etiological agent of scrub typhus, Orientia (formerly Rickettsia) tsutsugamushi (Hayashi), has been isolated from patients who live and work in the same habitat where L. chiangraiensis is the predominant Leptotrombidium species. RP Tanskul, P (reprint author), ARMED FORCES RES INST MED SCI,USA MED COMPONENT,DEPT ENTOMOL,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 5 TC 9 Z9 9 U1 0 U2 1 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1997 VL 34 IS 3 BP 368 EP 371 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA WY576 UT WOS:A1997WY57600019 PM 9151504 ER PT J AU Shriver, C Balingit, AG Caravalho, J Rodriguez, AA Jaques, DP ManiscalcoTheberge, M Deavers, M Krag, DN AF Shriver, C Balingit, AG Caravalho, J Rodriguez, AA Jaques, DP ManiscalcoTheberge, M Deavers, M Krag, DN TI Unfiltered Tc-99m-sulfur colloid lymphoscintigraphy and gamma-probe in detection of sentinel node in breast cancer patients SO JOURNAL OF NUCLEAR MEDICINE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,NUCL MED SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ANAT PATHOL,WASHINGTON,DC 20307. UNIV VERMONT,BURLINGTON,VT. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD MAY PY 1997 VL 38 IS 5 SU S BP 119 EP 119 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA WY980 UT WOS:A1997WY98000119 ER PT J AU Phung, D Balingit, AG Clement, S Sangar, V Bridwell, R Caravalho, J Rodriguez, A Judkiewicz, A Deavers, M AF Phung, D Balingit, AG Clement, S Sangar, V Bridwell, R Caravalho, J Rodriguez, A Judkiewicz, A Deavers, M TI Dual-radionuclide bone scintigraphy vs. MR imaging in patients with pedal ulcers and peripheral vascular disease. SO JOURNAL OF NUCLEAR MEDICINE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,NUCL MED SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ANAT PATHOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD MAY PY 1997 VL 38 IS 5 SU S BP 650 EP 650 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA WY980 UT WOS:A1997WY98000604 ER PT J AU Allen, TW RamosGabatin, A McBiles, M Blumhardt, R Lasher, J AF Allen, TW RamosGabatin, A McBiles, M Blumhardt, R Lasher, J TI Parathyroid scintigraphy: Patterns and pitfalls. SO JOURNAL OF NUCLEAR MEDICINE LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,SAN ANTONIO,TX. WILFORD HALL USAF MED CTR,SAN ANTONIO,TX 78236. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD MAY PY 1997 VL 38 IS 5 SU S BP 1128 EP 1128 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA WY980 UT WOS:A1997WY98001034 ER PT J AU Noel, JM Katona, IM PineiroCarrero, VM AF Noel, JM Katona, IM PineiroCarrero, VM TI Sarcoidosis resulting in duodenal obstruction in an adolescent SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION LA English DT Article ID ANGIOTENSIN-CONVERTING ENZYME; GASTROINTESTINAL SARCOIDOSIS; MANIFESTATIONS; ARTHROPATHY; DISEASE C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,F EDWARD HEBERT SCH MED,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. NR 25 TC 20 Z9 20 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0277-2116 J9 J PEDIATR GASTR NUTR JI J. Pediatr. Gastroenterol. Nutr. PD MAY PY 1997 VL 24 IS 5 BP 594 EP 598 DI 10.1097/00005176-199705000-00018 PG 5 WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics GA WY812 UT WOS:A1997WY81200017 PM 9161957 ER PT J AU Pai, SV Chabalowski, CF Rice, BM AF Pai, SV Chabalowski, CF Rice, BM TI Ab Initio and DFT potential energy surfaces for cyanuric chloride reactions SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID GAUSSIAN-BASIS SETS; CORRELATED MOLECULAR CALCULATIONS; DONOR-ACCEPTOR INTERACTIONS; REACTION DYNAMICS; ORBITAL METHODS; WAVE-FUNCTIONS; ATOMS AB Ab initio and nonlocal density functional theory (DFT) calculations were performed to determine reaction mechanisms for formation of the six-membered ring C3N3Cl3 (cyanuric chloride) from the monomer cyanogen chloride (ClCN). MP2 geometry optimizations followed by QCISD(T) energy refinements and corrections for zero-point energies for critical points on the potential energy surface were calculated using the 6-31G* and 6-311+G* basis sets. DFT (B3LYP) geometry optimizations and zero-point corrections for critical points on the potential energy surface were calculated with the 6-31G*, 6-311+G*, and cc-pVTZ basis sets. Good agreement is found for MP2 and DFT geometries and frequencies of cyanuric chloride and ClCN when compared with experimental values. Two formation mechanisms of cyanuric chloride were investigated, the concerted triple association (3 ClCN --> cyanuric chloride) and the stepwise association (3ClCN --> Cl2C2N2 + ClCN --> cyanuric chloride). All calculations show that the lower energy path to formation of cyanuric chloride is the concerted triple-association. MP2 and DFT intrinsic reaction coordinate calculations starting from the transition state for concerted triple association reaction proceeding toward the isolated monomer resulted in the location of a local minimum, stable by as much as 8.0 kcal/mol, that corresponds to a weakly-bound cyclic (ClCN)(3) cluster. The existence of this cluster on the reaction path for the concerted triple association could lower the entropic hindrance to this unusual association reaction mechanism. The DFT/cc-pVTZ barrier to concerted triple association relative to isolated ClCN is 42.9 kcal/mol. The QCISD(T)//MP2/6-311+G* barrier to concerted triple association is 41.0 kcal/mol. The DFT/cc-pVTZ barrier to formation of the dimer (stepwise association reaction) is 63.4 kcal/mol while the QCISD(T)//MP2/6-311+G* barrier is 76.7 kcal/mol. The barrier to formation of cyanuric chloride relative to the (ClCN)(3) minimum requires similar to 46-49 kcal/mol, indicating that the concerted triple-association reaction via formation of the (ClCN)(3) prereaction intermediate is the lower energy path to formation of cyanuric chloride. The temperature-corrected (T = 298 K) heats of reaction for formation of cyanuric chloride from ClCN are -63.4 and -61.2 kcal/mol for the B3LYP/cc-pVTZ and the QCISD(T)//MP2/6-311+G* predictions, respectively. C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. NR 32 TC 4 Z9 4 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD MAY 1 PY 1997 VL 101 IS 18 BP 3400 EP 3407 DI 10.1021/jp970009w PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA WX119 UT WOS:A1997WX11900030 ER PT J AU Yool, SR Makaio, MJ Watts, JM AF Yool, SR Makaio, MJ Watts, JM TI Techniques for computer-assisted mapping of rangeland change SO JOURNAL OF RANGE MANAGEMENT LA English DT Article DE remote sensing; GIS; change detection; range management ID SOUTHERN NEW-MEXICO; MESQUITE DUNELANDS; VEGETATION CHANGES; FORMER GRASSLANDS; DESERTIFICATION; REFLECTANCE; IMAGES; SOIL AB Management of grasslands subject to replacement by woody species requires an understanding of the scales and patterns of change and how to detect and express them, We used the Jornada del Muerto Basin of southern New Mexico as a case study, testing the suitability of Landsat Multi-Spectral Scanner (MSS) data for detecting vegetation changes, Cycles of drought and heavy grazing have apparently changed the once extensive grasslands of the upland Jornada and surrounding areas gradually into a patchwork of shrublands and relict grasslands, Integrated remote sensing and geographic information system (GIS) techniques can facilitate automated detection of these rangeland changes, A GIS was used to store and process two 4-band, co-registered multi-temporal Landsat MSS scenes collected in July 1983 and August 1992, Scene-to-scene radiometric calibration was performed using a regression technique, The data were then evaluated for changes 3 different ways using algorithms based on 1) differences between the 'red' (chlorophyll absorption) bands for the 2 scenes; 2) the Euclidean distances between the 'red' and 'near-infrared' bands for the 2 scenes; and 3) a standardized principal components analysis using all 8 MSS bands, A threshold of 3 standard deviations above the mean was applied to each of the 3 resulting 'change' images to represent areas of extreme change, Correlations among these images ranged between 0.83 and 0.95, We conclude these techniques can identify successfully the patterns and extent of extreme change, and thus have potential value for management of our rangelands resources. C1 USA,TOPOG ENGN CTR,ALEXANDRIA,VA 22315. RP Yool, SR (reprint author), UNIV ARIZONA,DEPT GEOG & REG DEV,TUCSON,AZ 85721, USA. NR 26 TC 17 Z9 17 U1 1 U2 4 PU SOC RANGE MANAGEMENT PI DENVER PA 1839 YORK ST, DENVER, CO 80206 SN 0022-409X J9 J RANGE MANAGE JI J. Range Manage. PD MAY PY 1997 VL 50 IS 3 BP 307 EP 314 DI 10.2307/4003734 PG 8 WC Agriculture, Dairy & Animal Science; Ecology SC Agriculture; Environmental Sciences & Ecology GA WY346 UT WOS:A1997WY34600016 ER PT J AU Soldatis, JJ Moseley, JB Etminan, M AF Soldatis, JJ Moseley, JB Etminan, M TI Shoulder symptoms in healthy athletes: A comparison of outcome scoring systems SO JOURNAL OF SHOULDER AND ELBOW SURGERY LA English DT Article AB We used the Rowe, ASES, UCLA, Constant-Murley, and the Simple Shoulder Test scoring systems to determine the presence and severity of shoulder symptoms in ''healthy'' collegiate athletes at mid-season. Intercollegiate athletes were surveyed with a single, specific, comprehensive questionnaire regarding both of their shoulders at the mid-season of their respective sport. The questionnaire compiled the previously mentioned scoring systems and additional inquiries. Shoulders were divided into three groups for analysis: dominant-never injured, nondominant-never injured, and history of injury. Significant shoulder symptoms exist in athletes during full participation in their respective sport. Pain was the most frequent symptom, with 47% of all shoulders having some degree of pain. The frequency and degree of symptoms was significantly greater in shoulders with a history of injury. The UCLA scoring system is the most sensitive for evaluating ''healthy'' athletes at mid-season. However, the ideal shoulder scoring system For athletes has yet to be developed. To expect a ''normal'' or ''symptom-free'' shoulder after injury or surgery may be inappropriate. This information can serve as a reference for clinicians when evaluating the results of surgery and other treatment programs. C1 BROOKE ARMY MED CTR,ORTHOPED SURG SERV,FT SAM HOUSTON,TX 78234. BAYLOR COLL MED,BAYLOR SPORTS MED INST,DEPT ORTHOPED SURG,HOUSTON,TX 77030. NR 4 TC 34 Z9 34 U1 0 U2 3 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1058-2746 J9 J SHOULDER ELB SURG JI J. Shoulder Elbow Surg. PD MAY-JUN PY 1997 VL 6 IS 3 BP 265 EP 271 DI 10.1016/S1058-2746(97)90015-X PG 7 WC Orthopedics; Sport Sciences; Surgery SC Orthopedics; Sport Sciences; Surgery GA XG492 UT WOS:A1997XG49200002 PM 9219131 ER PT J AU Arciero, RA Cruser, DL AF Arciero, RA Cruser, DL TI Pectoralis major rupture simultaneous anterior dislocation of the shoulder SO JOURNAL OF SHOULDER AND ELBOW SURGERY LA English DT Article ID MUSCLE RP Arciero, RA (reprint author), KELLER ARMY HOSP,ORTHOPAED SERV,W POINT,NY 10996, USA. NR 21 TC 20 Z9 20 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1058-2746 J9 J SHOULDER ELB SURG JI J. Shoulder Elbow Surg. PD MAY-JUN PY 1997 VL 6 IS 3 BP 318 EP 320 DI 10.1016/S1058-2746(97)90024-0 PG 3 WC Orthopedics; Sport Sciences; Surgery SC Orthopedics; Sport Sciences; Surgery GA XG492 UT WOS:A1997XG49200011 PM 9219140 ER PT J AU Mironenko, MV Grant, SA Marion, GM AF Mironenko, MV Grant, SA Marion, GM TI Calculation of densities of aqueous electrolyte solutions at subzero temperatures SO JOURNAL OF SOLUTION CHEMISTRY LA English DT Article DE electrolyte solution; density; subzero temperature; apparent molar volume; Pitzer equations ID NATURAL-WATERS; VOLUMETRIC PROPERTIES; MOLAL VOLUMES; 25-DEGREES-C; PREDICTION; MODEL; H2O AB We developed a FORTRAN program based on the Pitzer equations to calculate densities of electrolyte solutions at subzero temperatures. Data from the published literature collected at -28.9, -17.8, -12.2, -6.7, 0, and 25 degrees C were used to calculate the Pitzer-equation parameters and to evaluate model performance. Three approaches to estimating the molar volume of the solute at infinite dilution were evaluated: (1) extrapolation of apparent molar volumes to zero square-root ionic strength; (2) calculation with the Tanger and Helgeson model; and (3) global fit of the data in which the molar volume of the solute at infinite dilution was estimated along with the Pitzer-equation parameters. The last approach gave parameter estimates that reproduced the experimental data most accurately. The parameterized model predicted accurately densities of single-electrolyte and multielectrolyte solutions at -28.9, -17.8, -12.2, -6.7, 0, and 25 degrees C. Available experimental data are generally quite poor. Accordingly, Pitzer-equation parameters estimated for subzero temperatures should be viewed as conditional until improved measurements of single-electrolyte solution densities at subzero temperatures are made. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP Mironenko, MV (reprint author), VI VERNADSKII INST GEOCHEM & ANALYT CHEM,KOSYGIN ST 19,MOSCOW 117975,RUSSIA. NR 30 TC 9 Z9 9 U1 0 U2 11 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0095-9782 J9 J SOLUTION CHEM JI J. Solut. Chem. PD MAY PY 1997 VL 26 IS 5 BP 433 EP 460 DI 10.1007/BF02767600 PG 28 WC Chemistry, Physical SC Chemistry GA XQ016 UT WOS:A1997XQ01600002 ER PT J AU Atkinson, RH Hammons, MI AF Atkinson, RH Hammons, MI TI Tension stiffening behavior of reinforced masonry SO JOURNAL OF STRUCTURAL ENGINEERING-ASCE LA English DT Article ID MEMBERS AB The tensile behavior of reinforced concrete and clay unit masonry was studied by conducting a series of 33 direct tension tests on instrumented specimens. The effect of the steel reinforcement ratio was the principal variable considered. Reinforcing steel bars varied from no. 4 to no. 11 bars, while masonry unit widths varied from 90 to 290 mm. The measured tensile stress-strain curve permitted determination of the decrease in the tension stiffening behavior as a function of the cracking strain. All specimens were strained to levels far in excess of those permitted by design codes without suffering tensile bar failure. Initial behavior was governed by elastic properties. After cracking, a rapid decrease in effective stiffness was observed with the stiffness reducing to that of the reinforcing steel at a strain of approximately four times the cracking strain. This observation is significantly different from that reported for reinforced concrete. Examination of the stress-strain curve after yield showed a very strong influence of the reinforcing ratio on the shape of the stress-strain curve with lower steel ratios resulting in decreased ductility. C1 USA,CORPS ENGINEERS,WATERWAY EXPT STN,VICKSBURG,MS 39180. NR 14 TC 1 Z9 1 U1 1 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9445 J9 J STRUCT ENG-ASCE JI J. Struct. Eng.-ASCE PD MAY PY 1997 VL 123 IS 5 BP 597 EP 603 DI 10.1061/(ASCE)0733-9445(1997)123:5(597) PG 7 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA WV716 UT WOS:A1997WV71600009 ER PT J AU Summers, V Leek, MR AF Summers, V Leek, MR TI Intraspeech spread of masking in normal-hearing and hearing-impaired listeners SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID AUDITORY FILTER SHAPES; STOP CONSONANTS; FREQUENCY; RECOGNITION; FORMANT; NOISE; SPEECH AB Hearing-impaired and normal-hearing listeners labeled synthetic consonant-vowel stimuli (/ba/, /da/, /ga/, /be/, /de/, /ge/) presented at moderate and high signal levels. First formant (F1) regions were synthesized at normal and at attenuated levels to test whether F1 attenuation might reduce upward spread of masking, making information contained in higher formant regions more available. Performance was tested in quiet and in broadband noise sufficient to mask initial release bursts. Although complete removal of F1 consistently reduced performance, F1 attenuation of up to 18 dB led to increased labeling accuracy, particularly in the /a/ vowel context. Benefit associated with F1 attenuation was more consistently seen for hearing-impaired than for normal-hearing listeners and, in particular, for Listeners with steep increases in audiometric thresholds between the first and second formant regions of the test stimuli. The availability of initial bursts as a source of place cues during testing in quiet did not reduce the benefit associated with F1 attenuation. RP Summers, V (reprint author), USA,AUDIOL & SPEECH CTR,WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. FU NIDCD NIH HHS [DC 00626] NR 27 TC 11 Z9 11 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAY PY 1997 VL 101 IS 5 BP 2866 EP 2876 DI 10.1121/1.419303 PN 1 PG 11 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA WZ041 UT WOS:A1997WZ04100049 PM 9165738 ER PT J AU Wilson, DK AF Wilson, DK TI Scattering of acoustic waves by intermittent temperature and velocity fluctuations SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Letter AB The effect of atmospheric turbulent intermittency on acoustical scattering into shadow zones was discussed in a previous paper [D. K. Wilson, J. C. Wyngaard, and D. I. Havelock, J. Acoust. Sec. Am. 99, 3393-3400 (1996)]. Intermittency was incorporated into the classical scattering theory by defining a local mean scattered intensity, (I) over tilde(0), which has a log-normal probability density function (pdf), P-(I over tilde 0). The pdf P-I for the actual scattered intensity I was then determined from an integral equation involving P-(I over tilde 0). However, the discussion in Wilson et al. considered only intermittency in the velocity field. In this note, the combined effect of intermittency in both the velocity and temperature fields is considered. It is found that inclusion of temperature intermittency does not cause significant deviations from the log-normal pdf for P-(I over tilde 0). Hence the final results for the scattered intensity pdf P-I in Wilson et al. remain valid. RP Wilson, DK (reprint author), USA,RES LAB,ATTN,AMSRL,IS,EE,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 8 TC 6 Z9 6 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAY PY 1997 VL 101 IS 5 BP 2980 EP 2982 DI 10.1121/1.418525 PN 1 PG 3 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA WZ041 UT WOS:A1997WZ04100060 ER PT J AU Walsh, DS Balagon, MV Abalos, RM Tiongco, ES Cellona, RV Fajardo, TT Walsh, GP AF Walsh, DS Balagon, MV Abalos, RM Tiongco, ES Cellona, RV Fajardo, TT Walsh, GP TI Multiple lesions of sporotrichoid leishmaniasis in a Filipino expatriate SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID LYMPH-NODE INVOLVEMENT; CUTANEOUS LEISHMANIASIS; SAUDI-ARABIA; DISSEMINATION; FEATURES AB Sporotrichoid cutaneous leishmaniasis (CL) was diagnosed in a Filipino man who had worked in Saudi Arabia for 2 years. Two primary lesions-one on the forearm and one on the abdomen-were characterized by ''satellite'' papules and subcutaneous nodules extending proximally in a sporotrichoid pattern. Leishmania organisms were found in both primary lesions and a subcutaneous nodule. There was no evidence of systemic involvement. Recognition that Old World CL may disseminate through lymphatic channels has diagnostic and therapeutic importance. C1 AMER LEPROSY FDN,LEONARD WOOD MEM CTR LEPROSY RES,CEBU,PHILIPPINES. USA,MED COMPONENT,DEPT IMMUNOL,ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. NR 19 TC 14 Z9 14 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAY PY 1997 VL 36 IS 5 SU S BP 847 EP 849 DI 10.1016/S0190-9622(97)70038-0 PN 2 PG 3 WC Dermatology SC Dermatology GA WZ911 UT WOS:A1997WZ91100010 PM 9146565 ER PT J AU LaSala, JE Dietrick, K Benecke, G Buhr, T Gardner, D Gerving, C Perica, A AF LaSala, JE Dietrick, K Benecke, G Buhr, T Gardner, D Gerving, C Perica, A TI Measuring optical nonlinearities with a two-beam X-scan technique SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID SEMICONDUCTORS; SPECTROSCOPY; ABSORPTION; TIME; ZNSE AB We present a new two-beam technique, the X scan, for measuring both absorptive and refractive components of optical nonlinearities in bulk semiconductors, The sample is excited by a high-intensity, short (picosecond) pump pulse and is probed with weak degenerate or nondegenerate pulses whose relative arrival time and transverse alignment with the pump are varied. X scans at various delays enable separation of fi ee-carrier mediated nonlinearities and instantaneous chi((3)) nonlinearities. Varying the relative pump-probe polarizations yields components of the chi((3)) tensor. We report new values for degenerate (532 nm) and nondegenerate (532; 683 nm) cross-phase-modulation and two-photon-absorption coefficients for two polarization states and free-carrier absorption and refractive cross sections at 532 and 683 nm. (C) 1997 Optical Society of America. C1 US MIL ACAD,PHOTON RES CTR,W POINT,NY 10996. NR 21 TC 0 Z9 0 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD MAY PY 1997 VL 14 IS 5 BP 1138 EP 1148 DI 10.1364/JOSAB.14.001138 PG 11 WC Optics SC Optics GA WY400 UT WOS:A1997WY40000018 ER PT J AU Plotkin, D Kim, S AF Plotkin, D Kim, S TI Maglev guideway design issues SO JOURNAL OF TRANSPORTATION ENGINEERING-ASCE LA English DT Article AB This paper reports results from guideway analyses conducted as part of the National Maglev Initiative (NMI), a government-industry effort from 1989 to 1994, formed to encourage the development of U.S. maglev technology and to assess its potential application within the U.S. transportation system. Covered here are some key guideway design issues that were common to the designs assessed for the NMI, and to maglev guideways in general. They represent aspects that will need additional attention in future efforts to produce structurally sound and economical maglev guideways. These recommendations come from the analyses conducted by a team from the U.S. Army Construction Engineering Research Laboratories, the Civil Engineering Department of the University of Illinois, and Alfred Benesch and Company. The recommendations focus on design philosophy and the development of general design criteria, guideway maintenance and the provision for future alignment adjustment in both the guideway and the magnets, foundation design, and the long-term performance of guideway materials and reinforcement. Generally, one of the main challenges to guideway designers is to produce a structure that will be easily maintainable to the narrow tolerances and precise alignment required for practical high-speed maglev operation. RP Plotkin, D (reprint author), USA,CONSTRUCT ENGN RES LAB,POB 9005,CHAMPAIGN,IL 61826, USA. NR 0 TC 2 Z9 2 U1 2 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-947X J9 J TRANSP ENG-ASCE JI J. Transp. Eng.-ASCE PD MAY-JUN PY 1997 VL 123 IS 3 BP 189 EP 191 DI 10.1061/(ASCE)0733-947X(1997)123:3(189) PG 3 WC Engineering, Civil; Transportation Science & Technology SC Engineering; Transportation GA WV729 UT WOS:A1997WV72900005 ER PT J AU Beto, D Plotkin, D AF Beto, D Plotkin, D TI Designing concrete EDS Maglev guideways: Power losses in metallic reinforcement SO JOURNAL OF TRANSPORTATION ENGINEERING-ASCE LA English DT Article AB Conventional reinforced concrete designs will have to be altered when designing a guideway for a maglev using an electrodynamically suspended (EDS) propulsion system. This type of propulsion system generates large magnetic fields that will develop magnetically induced, circulating eddy currents in any conventional steel reinforcement in close proximity to the magnets. These eddy currents, if large enough, may produce significant power losses that could adversely effect operation of the system. This paper presents a method and explanation for civil engineers to use for estimating the power losses due to the presence of metallic reinforcement. This procedure may be used to help guide future designs in the selection and placement of reinforcing material. RP Beto, D (reprint author), USA,CONSTRUCT ENGN RES LAB,POB 9005,CHAMPAIGN,IL 61826, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-947X J9 J TRANSP ENG-ASCE JI J. Transp. Eng.-ASCE PD MAY-JUN PY 1997 VL 123 IS 3 BP 192 EP 194 DI 10.1061/(ASCE)0733-947X(1997)123:3(192) PG 3 WC Engineering, Civil; Transportation Science & Technology SC Engineering; Transportation GA WV729 UT WOS:A1997WV72900006 ER PT J AU Plotkin, D Kim, S AF Plotkin, D Kim, S TI Maglev guideway cost and construction schedule assessment SO JOURNAL OF TRANSPORTATION ENGINEERING-ASCE LA English DT Article AB A summary of construction cost and scheduling information is presented for four maglev guideway designs on an example route from Baltimore, MD to Newark, N.J. This work results from the National Maglev Initiative (NMI), a government-industry effort from 1989 to 1994. The system design concepts used as a basis for developing cost and construction scheduling information, were submitted by four industry consortia solely for this analysis, and represent their own unpublished designs. The detailed cost and construction schedule analyses cover the main guideway only. A summary estimate was made for stations, power distribution systems, maintenance facilities, and other types of infrastructure. The results of the analyses indicate a number of design aspects which must receive further consideration by future designers. These aspects will affect the practical and economic construction and long-term maintenance of a high-speed maglev guideway. RP Plotkin, D (reprint author), USA,CONSTRUCT ENGN RES LAB,POB 9005,CHAMPAIGN,IL 61826, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-947X J9 J TRANSP ENG-ASCE JI J. Transp. Eng.-ASCE PD MAY-JUN PY 1997 VL 123 IS 3 BP 195 EP 198 DI 10.1061/(ASCE)0733-947X(1997)123:3(195) PG 4 WC Engineering, Civil; Transportation Science & Technology SC Engineering; Transportation GA WV729 UT WOS:A1997WV72900007 ER PT J AU Plotkin, D AF Plotkin, D TI Carrying freight on high-speed rail lines SO JOURNAL OF TRANSPORTATION ENGINEERING-ASCE LA English DT Article AB Under the current economic climate it is expected that any new high-speed rail line in the United States would be constructed as a public/private partnership, requiring substantial private investment, and thus the expectation of reasonable profits. To date, proposed high-speed rail lines have failed to attract sufficient investment to create any new starts, in great part due to the conclusion that these systems would not likely cover their capital and operating costs and also provide reasonable profit for investors. Studies of the economic potential of U.S. high-speed rail lines have commonly considered them as passenger carriers only, depending solely on ridership as a source of revenue. Yet it is likely that significant revenue potential exists for carrying higher value freight as well-perhaps enough to substantially improve the economic viability of certain high-speed operations. Some basic technical aspects of carrying freight on high-speed rail lines are presented, along with an analysis to estimate the quantity of freight that may be technically practical and thus potentially economically viable, for a high-speed train to carry. RP Plotkin, D (reprint author), USA,CONSTRUCT ENGN RES LAB,POB 9005,CHAMPAIGN,IL 61826, USA. NR 5 TC 2 Z9 2 U1 0 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-947X J9 J TRANSP ENG-ASCE JI J. Transp. Eng.-ASCE PD MAY-JUN PY 1997 VL 123 IS 3 BP 199 EP 201 DI 10.1061/(ASCE)0733-947X(1997)123:3(199) PG 3 WC Engineering, Civil; Transportation Science & Technology SC Engineering; Transportation GA WV729 UT WOS:A1997WV72900008 ER PT J AU deFigueiredo, LFP Mathru, M Solanki, D MacDonald, VW Hess, J Kramer, GC AF deFigueiredo, LFP Mathru, M Solanki, D MacDonald, VW Hess, J Kramer, GC TI Pulmonary hypertension and systemic vasoconstriction may offset the benefits of acellular hemoglobin blood substitutes SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 56th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 19-21, 1996 CL HOUSTON, TX SP Amer Assoc Surg Trauma DE blood substitutes; hemoglobin; hemorrhage; microspheres; nitric oxide; regional blood flow; shock; vasoconstriction ID CROSS-LINKED HEMOGLOBIN; OXYGEN-CARRYING SOLUTIONS; STROMA-FREE HEMOGLOBIN; CELL-FREE HEMOGLOBIN; NITRIC-OXIDE; REGIONAL CIRCULATION; RESUSCITATIVE FLUID; HYPERTONIC SALINE; HEMORRHAGE; RATS AB Objective: We tested the hypothesis that the pharmacologic properties of a small volume of alpha alpha-cross-linked hemoglobin (alpha alpha Hb) could effectively resuscitate pigs subjected to hemorrhage, Methods: Fourteen pigs hemorrhaged to a mean arterial pressure (MAP) of 40 mm Hg for 60 minutes were treated with a 4-mL/kg 2-minute infusion of 10 g/dL alpha alpha Hb or 7 g/dL human serum albumin, an oncotically matched control solution, Results: The removal of blood (17 +/- 1.5 mL/kg) caused the typical physiologic responses to hemorrhagic hypovolemia, Infusion of alpha alpha Hb restored mean arterial pressure and coronary perfusion pressure, but cardiac output and mixed venous O-2 saturation did not improve significantly, Pulmonary arterial pressure and pulmonary vascular resistance increased markedly and were higher than baseline levels after alpha alpha Hb. Infusion of human serum albumin produced only minor hemodynamic changes, Brain blood flow did improve to baseline values after alpha alpha Hb, but was the only tissue to do so, In the human serum albumin group, superior mesenteric artery blood flow recovered to baseline values, whereas brain blood flow did not, Blood flows to other tissues were similar in both groups, Conclusion: Small-volume infusion of alpha alpha Hb restored mean arterial pressure and brain blood flow, but pulmonary hypertension and low peripheral perfusion may offset benefits for trauma patients. C1 UNIV TEXAS,MED BRANCH,DEPT ANESTHESIOL,GALVESTON,TX 77550. UNIV TEXAS,MED BRANCH,DEPT PHYSIOL,GALVESTON,TX 77550. UNIV TEXAS,MED BRANCH,DEPT BIOPHYS,GALVESTON,TX 77550. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,BLOOD RES DETACHMENT,WASHINGTON,DC 20307. RP deFigueiredo, LFP (reprint author), UNIV SAO PAULO,FM,INCOR,DEX,HEART INST,DEPT CARDIOPNEUMOL,BR-05403000 SAO PAULO,BRAZIL. NR 46 TC 35 Z9 36 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 1997 VL 42 IS 5 BP 847 EP 854 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA XD789 UT WOS:A1997XD78900022 PM 9191666 ER PT J AU Moul, JW AF Moul, JW TI Molecular genetics of testicular cancer SO JOURNAL OF UROLOGY LA English DT Editorial Material ID PROTEIN; TUMORS RP Moul, JW (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAY PY 1997 VL 157 IS 5 BP 1552 EP 1553 DI 10.1016/S0022-5347(01)64791-8 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA WU178 UT WOS:A1997WU17800002 ER PT J AU McLane, GF Wood, MC Eckart, DW Lee, JW Lee, KN Pearton, SJ Abernathy, CR AF McLane, GF Wood, MC Eckart, DW Lee, JW Lee, KN Pearton, SJ Abernathy, CR TI Dry etching of InGaP in magnetron enhanced BCl3 plasmas SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 43rd American-Vacuum-Society Symposium CY OCT 14-18, 1996 CL PHILADELPHIA, PA SP Amer Vacuum Soc ID HETEROSTRUCTURES; IN0.5GA0.5P AB Magnetron enhanced reactive ion etching of In0.5Ga0.5P was investigated in BCl3 plasmas. Etch rates were determined as a function of cathode power (0.2-0.5 W/cm(2)), BCl3 flow rate (3-12 seem), and pressure (2-10 mTorr), with rates as high as 0.35 mu m/min achieved. The addition of N-2, O-2, and Ar to BCl3 was ineffective in producing an etch rate increase. Changes in sheet resistance and photoluminescence of n- and p-type InGaP exposed to BCl3 plasmas were also investigated as a function of power, pressure, and etch duration. The n-type material was more susceptible to etch-induced damage than p-type material, suggesting that electron traps are produced by ion bombardment. Scanning electron micrographs showed etched surfaces to be smooth, with vertical sidewalls free of undercut. (C) 1997 American Vacuum Society. C1 UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611. RP McLane, GF (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 11 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD MAY-JUN PY 1997 VL 15 IS 3 BP 622 EP 625 DI 10.1116/1.580694 PN 1 PG 4 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA XE731 UT WOS:A1997XE73100030 ER PT J AU Ren, F Vartuli, CB Pearton, SJ Abernathy, CR Donovan, SM MacKenzie, JD Shul, RJ Zolper, JC Lovejoy, ML Baca, AG HagerottCrawford, M Jones, KA AF Ren, F Vartuli, CB Pearton, SJ Abernathy, CR Donovan, SM MacKenzie, JD Shul, RJ Zolper, JC Lovejoy, ML Baca, AG HagerottCrawford, M Jones, KA TI Comparison of ohmic metallization schemes for InGaAlN SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 43rd American-Vacuum-Society Symposium CY OCT 14-18, 1996 CL PHILADELPHIA, PA SP Amer Vacuum Soc ID LIGHT-EMITTING-DIODES; FIELD-EFFECT TRANSISTOR; MOLECULAR-BEAM EPITAXY; GAN; CONTACTS; INN; RESISTANCE; GROWTH; BLUE AB W, WSi0.44, and Ti/Al contacts were examined on n(+)In(0.65)Ga(0.35)N, InN, and In0.75Al0.25N. W Was found to produce low specific contact resistance (Q(c) similar to 10(-7) Omega cm(2)) ohmic contacts to InGaN, while WSis showed an as-deposited Q(c) of 4 x 10(-7) Omega cm(2) but this degraded significantly with subsequent annealing, reaching 10(-5) Omega cm(2) at 700 degrees C. Ti/Al contacts on InGaN were stable to similar to 600 degrees C (Q(c) similar to 4 x 10(-7) Omega cm(2) at less than or equal to 600 degrees C). InN contacted with W and Ti/Al produced ohmic contacts with Q(c) similar to 10(-7) Omega cm(2) and for WSix Q(c) similar to 10(-6) Omega cm(2) and all three metallization schemes retained values less than or equal to 10(-6) Omega cm(2) up to 600 degrees C. The contact resistances for all of the metals were greater than or equal to 10(-4) Omega cm(2) on InAlN, and degraded with subsequent annealing. WSix contacts on InN grown graded from In0.6Al0.4N were also examined. The specific contact resistance was an order of magnitude lower (Q(c) similar to 10(-5) Omega cm(2)) after 500 degrees C anneal than that measured for WSix deposited directly on In0.6Al0.4N. Measurements of the temperature dependence of these contact structures showed that field emission was generally the most important conduction mechanism. (C) 1997 American Vacuum Society. C1 UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611. AT&T BELL LABS,LUCENT TECHNOL,MURRAY HILL,NJ 07974. SANDIA NATL LABS,ALBUQUERQUE,NM 87185. USA,RES LAB,FT MONMOUTH,NJ 07703. NR 20 TC 9 Z9 9 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD MAY-JUN PY 1997 VL 15 IS 3 BP 802 EP 806 DI 10.1116/1.580711 PN 1 PG 5 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA XE731 UT WOS:A1997XE73100065 ER PT J AU Pethel, SD Bowden, CM Sung, CC AF Pethel, SD Bowden, CM Sung, CC TI Strategy for enhanced high-field ionization suppression SO LASER PHYSICS LA English DT Article ID LASER FIELD; HIGH-FREQUENCY; STABILIZATION; INTENSE; ATOMS; STABILITY; HYDROGEN; STATES AB An earlier study of atomic hydrogen ionization suppression in the classical ensemble established the existence of an optimum ramp-up of turn-on to very high fields. In this work, the role of the field turn-on is corroborated with an analysis of the relative stability of orbits of the classical ensemble. A strategy to initiate an optimum ensemble for enhanced suppression is demonstrated by using a prepulse. RP Pethel, SD (reprint author), USA,MISSILE COMMAND,WEAPONS SCI DIRECTORATE,AMSMI RD WS ST RES,DEV & ENGN CTR,REDSTONE ARSENAL,AL 35898, USA. NR 12 TC 2 Z9 2 U1 0 U2 0 PU INTERPERIODICA PI BIRMINGHAM PA PO BOX 1831, BIRMINGHAM, AL 35201-1831 SN 1054-660X J9 LASER PHYS JI Laser Phys. PD MAY-JUN PY 1997 VL 7 IS 3 BP 558 EP 562 PG 5 WC Optics; Physics, Applied SC Optics; Physics GA XH417 UT WOS:A1997XH41700006 ER PT J AU Burgess, EB AF Burgess, EB TI The memoirs of Cleopatra - George,M SO LIBRARY JOURNAL LA English DT Book Review RP Burgess, EB (reprint author), USA,COMBINED ARMS RES LIB,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD MAY 1 PY 1997 VL 122 IS 8 BP 139 EP 139 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA WV949 UT WOS:A1997WV94900234 ER PT J AU Conway, TG AF Conway, TG TI Improved remote heat sensing SO MECHANICAL ENGINEERING LA English DT Article RP Conway, TG (reprint author), USA,MAT COMMAND,ALEXANDRIA,VA, USA. NR 0 TC 1 Z9 2 U1 0 U2 0 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0025-6501 J9 MECH ENG JI Mech. Eng. PD MAY PY 1997 VL 119 IS 5 BP 88 EP 89 PG 2 WC Engineering, Mechanical SC Engineering GA WW603 UT WOS:A1997WW60300037 ER PT J AU Montain, SJ Laird, JE Latzka, WA Sawka, MN AF Montain, SJ Laird, JE Latzka, WA Sawka, MN TI Aldosterone and vasopressin responses in the heat: Hydration level and exercise intensity effects SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE dehydration; osmolality; body fluid balance; fluid regulatory hormones; antidiuretic hormone ID GRADED HYPOHYDRATION LEVELS; PLASMA VASOPRESSIN; HORMONAL RESPONSES; RENAL RESPONSES; BLOOD-VOLUME; RENIN; DEHYDRATION; WATER; ELECTROLYTE; ACCLIMATION AB We examined the separate and combined effects of hypohydration level and exercise intensity on aldosterone (ALD) and arginine vasopressin (AVP) responses during exercise-heat stress. Nine heat acclimated men performed 50 min of treadmill exercise in a warm room (30 degrees C dry bulb (DB), 50% relative humidity (RH) at 25%, 45% and 65% VO2max when euhydrated and when hypohydrated by 3% and 5% of body weight. Blood samples were drawn at rest and at 20 min of exercise. ALD and AVP increased (P < 0.05) in a graded manner with hypohydration level, and this effect persisted during exercise-heat stress. High intensity exercise produced greater ALD and AVP increases than low intensity exercise. ALD responses during exercise were independent of hypohydration level. AVP responses were closely related to osmolality (N = 6 of 7 subjects; r = 0.51 to r = 0.98; average r = 0.84) despite varying hydration, exercise intensity, or core temperature. We conclude that: 1) ALD and AVP increase in a graded manner with hypohydration, and this effect persists during exercise-heat stress; 2) ALD and AVP increases elicited by exercise are greater during high intensity than low intensity exercise; 3) Hypohydration and exercise intensity have additive effects on ALD; and 4) AVP responses are closely coupled to osmolality. RP Montain, SJ (reprint author), USA,INST ENVIRONM MED,THERMAL & MT MED DIV,NATICK,MA 01760, USA. NR 29 TC 35 Z9 39 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 1997 VL 29 IS 5 BP 661 EP 668 DI 10.1097/00005768-199705000-00012 PG 8 WC Sport Sciences SC Sport Sciences GA WW608 UT WOS:A1997WW60800012 PM 9140904 ER PT J AU Sallum, MAM Wilkerson, RC AF Sallum, MAM Wilkerson, RC TI Description of the immature stages of Anopheles (Nyssorhynchus) rondoni (Neiva & Pinto) (Diptera: Culicidae) SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE Anopheles (Nyssorhynchus) rondoni; larva; pupa; description; key characters ID BRAZIL AB The larval and pupal stages of Anopheles (Nyssorhynchus) rondoni (Neiva and Pinto) (Albimanus Section) are fully described and illustrated for the first time. The larval stage is similar to An. (Nys.) strodei Root. It can be recognized by the following combination of characters: clypeal index, 1.6-2.9; single, aciculate setae 2,3-C; sera 3-C 0.5-0.7 the length of 2-C; setae 1,2-P rarely sharing a common tubercle; seta 1-P with narrow leaflets. The pupal stage is distinguished from other Nyssorhynchus by having setae I-IV-VII and 5-V-VII branched. Only minor variation was found in setal counts between specimens from Peixoto de Azevedo, State of Mato Grosso and Bocaina, State of Sao Paulo, Brazil. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. RP Sallum, MAM (reprint author), UNIV SAO PAULO,FAC SAUDE PUBL,DEPT EPIDEMIOL,NUPTEM,AV DR ARNALDO 715,BR-01246904 SAO PAULO,BRAZIL. RI Sallum, Maria/B-8537-2012 NR 10 TC 2 Z9 2 U1 0 U2 2 PU FUNDACO OSWALDO CRUZ PI RIO DE JANEIRO, RJ PA AV BRASIL 4365, 21045-900 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD MAY-JUN PY 1997 VL 92 IS 3 BP 365 EP 372 DI 10.1590/S0074-02761997000300012 PG 8 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA WX327 UT WOS:A1997WX32700012 PM 9332603 ER PT J AU Petrali, JP OglesbyMegee, S AF Petrali, JP OglesbyMegee, S TI Toxicity of mustard gas skin lesions SO MICROSCOPY RESEARCH AND TECHNIQUE LA English DT Article DE sulfur mustard (HD); ultrastructure; immunohistochemistry; animal models; pathology; skin ID BULLOUS PEMPHIGOID ANTIGEN; HAIRLESS GUINEA-PIG; SULFUR MUSTARD; EPIDERMOLYSIS-BULLOSA; EQUIVALENT; SULFIDE; INVITRO AB Although the exact pathogenesis of mustard gas-induced dermal toxicity remains elusive, morphopathological data gathered in controlled animal and in vitro investigations is providing important clues as to approximate mechanisms. Our laboratory has been studying dermal effects of the chemical warfare agent, sulfur mustard, in a variety of animal models, cultured isolated human cells, and in vitro organotypic skin models. Published anatomical, pathological, and ultrastructural results of these studies have documented consistent cellular and basement membrane zone effects irrespective of the model. Cellular effects include the early targeting of basal cells of the stratum basale to the exclusion of other epidermal cells, with nuclear and cytoplasmic indications of cell injury and cell death. Effects on the basement membrane zone include the formation of characteristic microvesicles in the lamina lucida of those models which possessed structural components of a true basement membrane. We are now investigating effects on proteins of the basement membrane microenvironment and correlate in the present paper the morphopathology of sulfur mustard dermal lesion with immunohistochemical study of bullous pemphigoid antigen, laminin, type IV collagen, and type VII collagen. (C) Wiley-Liss, Inc. RP Petrali, JP (reprint author), USA,MED RES INST CHEM DEF,COMPARAT PATHOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 25 TC 45 Z9 45 U1 1 U2 4 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 1059-910X J9 MICROSC RES TECHNIQ JI Microsc. Res. Tech. PD MAY 1 PY 1997 VL 37 IS 3 BP 221 EP 228 DI 10.1002/(SICI)1097-0029(19970501)37:3<221::AID-JEMT7>3.0.CO;2-Q PG 8 WC Anatomy & Morphology; Biology; Microscopy SC Anatomy & Morphology; Life Sciences & Biomedicine - Other Topics; Microscopy GA WX213 UT WOS:A1997WX21300007 PM 9144634 ER PT J AU James, LC Folen, RA Garland, FN Edwards, C Noce, M Gohdes, D Williams, D Bowles, S Kellar, MA Supplee, E AF James, LC Folen, RA Garland, FN Edwards, C Noce, M Gohdes, D Williams, D Bowles, S Kellar, MA Supplee, E TI The Tripler Army Medical Center LEAN Program: A healthy lifestyle model for the treatment of obesity SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Hawaii-Psychological-Association Convention CY JAN 25, 1996 CL HONOLULU, HI SP Hawaii Psycholog Assoc ID TERM FOLLOW-UP; WEIGHT-LOSS AB This paper provides an overview of the Tripler Army Medical Center LEAN Program for the treatment of obesity, hypercholesterolemia, and essential hypertension. The LEAN Program, a multi-disciplinary prevention program, emphasizes healthy Lifestyles, Exercise and Emotions, Attitudes, and Nutrition for active duty service members. The treatment model offers a medically healthy, emotionally safe, and reasonable, low-intensity exercise program to facilitate weight loss. We will discuss the philosophy behind the LEAN Program and the major components. Thereafter, we will briefly discuss the preliminary results. RP James, LC (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 22 TC 11 Z9 12 U1 1 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1997 VL 162 IS 5 BP 328 EP 332 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA WZ087 UT WOS:A1997WZ08700008 PM 9155102 ER PT J AU Taylor, T Ila, D Zimmerman, RL Ashley, PR Poker, DB Hensley, DK AF Taylor, T Ila, D Zimmerman, RL Ashley, PR Poker, DB Hensley, DK TI Optical changes induced in GaAs/AlGaAs waveguides by MeV ion bombardment SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article; Proceedings Paper CT 10th International Conference on Ion Beam Modification of Materials (IBMM-96) CY SEP 01-06, 1996 CL ALBUQUERQUE, NM ID WAVE-GUIDES; IMPURITY AB We have fabricated optical channel waveguides in selectively masked planar GaAs/AlGaAs waveguide structures using MeV carbon and oxygen ions without post annealing. The fabricated channel waveguides were characterized exclusively by performing optical transmission measurements at a wavelength of 1.3 mu m Investigation of the extracted optical results reveals that further optimization of the ion beam parameters is required to reduce the observed propagation loss values. The feasibility of this technique may provide a totally new concept of localized optical modifications in the GaAs/AlGaAs system. C1 USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898. OAK RIDGE NATL LAB,DIV SOLID STATE,OAK RIDGE,TN 37831. RP Taylor, T (reprint author), ALABAMA A&M UNIV,DEPT PHYS,CTR IRRADIAT MAT,NORMAL,AL 35762, USA. RI Hensley, Dale/A-6282-2016 OI Hensley, Dale/0000-0001-8763-7765 NR 9 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD MAY PY 1997 VL 127 BP 442 EP 445 DI 10.1016/S0168-583X(96)00970-6 PG 4 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA XG605 UT WOS:A1997XG60500099 ER PT J AU Demaree, JD Kirkpatrick, SR Kirkpatrick, AR Hirvonen, JK AF Demaree, JD Kirkpatrick, SR Kirkpatrick, AR Hirvonen, JK TI Modification of single-crystal sapphire by ion implantation SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article; Proceedings Paper CT 10th International Conference on Ion Beam Modification of Materials (IBMM-96) CY SEP 01-06, 1996 CL ALBUQUERQUE, NM AB Some studies have shown that single-crystal sapphire can exhibit a dramatic loss of compressive strength (over 90%) at high temperatures, limiting its use as a shatter-resistant optical window. Other studies have shown that the mechanical behavior of sapphire can be improved by ion implantation, hardening the near-surface region and introducing a compressive stress state, perhaps leading to an increase in the fracture toughness of the material. In this study, we have examined the extent to which sapphire can be implanted without severely degrading its optical quality by ion beam defect production. Optically-polished single-crystal c-axis sapphire was implanted with 15O-keV Cr+, Ti+, and Si+ ions to doses of (0.3-3.0) x 10(17) ions/cm(2) at both room temperature and at 800 degrees C, to measure the optical effect of in situ annealing. Optical properties were measured by visible light transmission and Fourier transform infrared spectroscopy; the depth and composition of the implanted layer was characterized with Rutherford backscattering spectrometry; and the topography of the implanted surface was examined with photon tunneling microscopy. C1 EPION CORP,BEDFORD,MA 01730. RP Demaree, JD (reprint author), USA,RES LAB,MAT DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. NR 5 TC 15 Z9 16 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD MAY PY 1997 VL 127 BP 603 EP 607 DI 10.1016/S0168-583X(96)01128-7 PG 5 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA XG605 UT WOS:A1997XG60500137 ER PT J AU Pierce, DE Pfeffer, RL Sadler, GD AF Pierce, DE Pfeffer, RL Sadler, GD TI Rutherford backscattering analysis of contaminants in PET SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article DE recycling; pesticides; poly(ethylene terephthalate); RBS ID SIZE AB Rutherford Backscattering Spectrometry (RES) was used to understand the sorption and desorption of organic contaminants in the polymer Poly(ethylene terephthalate), or PET. Samples were exposed to a range of organics to simulate contamination of PET that can take place in the post-consumer waste stream. From RES analysis, concentration depth profiles were shown to vary from a monolayer regime surface layer to a saturation level, depending on the contaminant. Heat treatments were also applied to contaminated polymer to simulate thermal processing steps in the recycling of PET. Heating caused a dramatic decrease in contaminants and in some cases a complete removal of contamination was achieved to the limit of RES detectability. C1 IIT,NATL CTR FOOD SAFETY & TECHNOL,SUMMIT ARGO,IL 60501. RP Pierce, DE (reprint author), USA,RES LAB,SENSORS & ELECTRON DEVICES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 9 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD MAY PY 1997 VL 124 IS 4 BP 575 EP 578 DI 10.1016/S0168-583X(97)00093-1 PG 4 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA WY067 UT WOS:A1997WY06700021 ER PT J AU Gurney, CA Mueller, CW Price, JL AF Gurney, CA Mueller, CW Price, JL TI Job satisfaction and organizational attachment of nurses holding doctoral degrees SO NURSING RESEARCH LA English DT Article ID CAUSAL MODEL; COMMITMENT; TURNOVER; WORK AB A model explaining job satisfaction and organizational attachment (commitment and intent to leave) was estimated for a national sample of nurses holding doctoral degrees and employed in academic and nonacademic settings. The purpose of the study was (a) to test a model from Price-Mueller that has been used primarily for nurses who do not have their doctorates and (b) to determine if the results of the test were consistent with expectations from the professions literature. The results showed that although nursing is categorized as a semiprofession in the professions literature, the satisfaction and attachment of nurses holding doctorate degrees was explained by variables from arguments about numbers of the well-established professions, known as the ''true'' professions. C1 UNIV IOWA,DEPT SOCIOL,IOWA CITY,IA 52242. RP Gurney, CA (reprint author), BROOKE ARMY MED CTR,NURSING EDUC & RES SERV,FT SAM HOUSTON,SAN ANTONIO,TX, USA. NR 51 TC 32 Z9 32 U1 1 U2 8 PU AMER J NURSING CO PI NEW YORK PA 555 W 57TH ST, NEW YORK, NY 10019-2961 SN 0029-6562 J9 NURS RES JI Nurs. Res. PD MAY-JUN PY 1997 VL 46 IS 3 BP 163 EP 171 DI 10.1097/00006199-199705000-00007 PG 9 WC Nursing SC Nursing GA XB415 UT WOS:A1997XB41500007 PM 9176506 ER PT J AU Allik, TH Chandra, S Rines, DM Schunemann, PG Hutchinson, JA Utano, R AF Allik, TH Chandra, S Rines, DM Schunemann, PG Hutchinson, JA Utano, R TI Tunable 7-12-mu m optical parametric oscillator using a Cr,Er:YSGG laser to pump CdSe and ZnGeP2 crystals SO OPTICS LETTERS LA English DT Article AB A CdSe optical parametric oscillator (OPO) pumped by a 2.79-mu m, Cr,Er:YSGG laser yielded a 59% signal-plus-idler slope efficiency (eta), a total idler output of 1.2-2.4 mJ between 8.5 and 12.3 mu m, and an idler beam that was 2.2-2.5 times the diffraction limit. A ZnGeP2 OPO operated with a lower threshold, eta = 29%, and a forward idler output of 0.7-2.4 mJ from 6.9 to 9.9 mu m. The signal and idler bandwidths were typically 4 cm(-1) for each OPO. (C) 1997 Optical Society of America. C1 LOCKHEED SANDERS INC,NASHUA,NH 03061. USA,CECOM,NIGHT VIS & ELECT SENSORS DIRECTORATE,FT BELVOIR,VA 22060. RP Allik, TH (reprint author), SCI APPLICAT INT CORP,1710 GOODRIDGE DR,MCLEAN,VA 22102, USA. NR 7 TC 53 Z9 53 U1 5 U2 23 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD MAY 1 PY 1997 VL 22 IS 9 BP 597 EP 599 DI 10.1364/OL.22.000597 PG 3 WC Optics SC Optics GA WW161 UT WOS:A1997WW16100007 PM 18185602 ER PT J AU Bass, JW AF Bass, JW TI Obesity and penicillin dosage - Reply SO PEDIATRICS LA English DT Letter ID STREPTOCOCCAL PHARYNGITIS; BENZATHINE; CHILDREN RP Bass, JW (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96959, USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 1997 VL 99 IS 5 BP 755 EP 756 PG 2 WC Pediatrics SC Pediatrics GA WX728 UT WOS:A1997WX72800039 ER PT J AU Leo, KU Grace, JM Li, QG Peggins, J Mitchell, AL Aguilar, T Brewer, TG AF Leo, KU Grace, JM Li, QG Peggins, J Mitchell, AL Aguilar, T Brewer, TG TI Effects of Plasmodium berghei infection on arteether metabolism and disposition SO PHARMACOLOGY LA English DT Article DE drug metabolism; antimalarials; malaria; cytochrome P450 (CAP450); arteether; dihydroqinghaosu ID PERFUSED RAT-LIVER; MALARIA INFECTION; PHARMACOKINETICS; MICROSOMES AB Arteether (AE) is primarily deethylated to dihydroqinghaosu (DQHS) in rats and humans. Conversion of AE to DQHS was impaired in microsomes from rats infected with Plasmodium berghei. The K-m for AE was 175.1 +/- 49.1 and 124.4 +/- 115.1 mu mol/l, and V-max was 2.24 +/- 0.45 and 1.22 +/- 0.67 nmol AE formed/mg protein/min in control and infected microsomes (p < 0.05), respectively, Calculated intrinsic clearance (CLint = initial V-max/K-m) for AE was only 4% lower in infected microsomes. Apparent pharmacokinetic parameter estimates for AE using the isolated perfused rat liver demonstrated no differences (p > 0.05) in volume of distribution, clearance, and half-life between normal and infected animals. Malaria infection resulted in decreased biliary excretion of free AE and DQHS. The majority of AE is eliminated via biliary excretion of conjugated DQHS, which is approximately 500-fold higher than free DQHS and 75-fold higher than free AE on a molar basis. C1 ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. RP Leo, KU (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPT THERAPEUT,WASHINGTON,DC 20307, USA. NR 27 TC 8 Z9 8 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0031-7012 J9 PHARMACOLOGY JI Pharmacology PD MAY PY 1997 VL 54 IS 5 BP 276 EP 284 DI 10.1159/000139496 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA XN515 UT WOS:A1997XN51500007 PM 9380774 ER PT J AU Sliney, DH AF Sliney, DH TI Optical radiation safety of medical light sources SO PHYSICS IN MEDICINE AND BIOLOGY LA English DT Article ID ULTRAVIOLET-RADIATION; ACTION SPECTRUM; HAZARDS; DAMAGE; CATARACTOGENESIS; OPHTHALMOSCOPES AB The phototoxicity of medical ultraviolet (UV) sources used in dermatology has long been recognized. Less obvious are potential hazards to the eye and skin from many other optical sources-both to the patient and to the health-care worker. To assess potential hazards, one must consider not only the optical and radiometric parameters of the optical source in question but also the geometrical exposure factors. This knowledge is required to accurately determine the irradiances (dose rates) to exposed tissues. Both photochemically and thermally induced damage are possible from intense light sources used in medicine and surgery; however, thermal injury is rare unless the light source is pulsed or nearly in contact with tissue. Generally, photochemical interaction mechanisms are most pronounced at short wavelengths (UV) where photon energies are greatest, and also will be most readily observed for lengthy exposure durations. RP Sliney, DH (reprint author), USA,CTR HLTH PROMOT & PREVENT MED,LASER OPT RADIAT PROGRAM,ABERDEEN PROVING GROUND,MD 21010, USA. NR 64 TC 21 Z9 23 U1 0 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL, ENGLAND BS1 6BE SN 0031-9155 J9 PHYS MED BIOL JI Phys. Med. Biol. PD MAY PY 1997 VL 42 IS 5 BP 981 EP 996 DI 10.1088/0031-9155/42/5/016 PG 16 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA WZ953 UT WOS:A1997WZ95300016 PM 9172271 ER PT J AU Moseley, H Sliney, DH AF Moseley, H Sliney, DH TI Radiometric quantities and units SO PHYSICS IN MEDICINE AND BIOLOGY LA English DT Article C1 USA,CTR HLTH PROMOT & PREVENT MED,ABERDEEN PROVING GROUND,MD. RP Moseley, H (reprint author), UNIV DUNDEE,DUNDEE DD1 4HN,SCOTLAND. NR 4 TC 0 Z9 0 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL, ENGLAND BS1 6BE SN 0031-9155 J9 PHYS MED BIOL JI Phys. Med. Biol. PD MAY PY 1997 VL 42 IS 5 BP U5 EP U6 PG 2 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA WZ953 UT WOS:A1997WZ95300002 ER PT J AU Lee, RH Gamble, WB Mayer, MH Manson, PN AF Lee, RH Gamble, WB Mayer, MH Manson, PN TI Patterns of facial laceration from blunt trauma SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID SKIN TENSION LINES; INJURIES AB The clinical characteristics of craniofacial injuries resulting from various modes of blunt trauma, including motor vehicle accidents, falls, and assault, have been described extensively in the literature. In this study, specifically targeted blunt trauma to selected areas of the face was used to recreate soft-tissue laceration injuries on 19 cadaver heads. The patterns of laceration produced were then examined by location, size, penetrated skin depth, and associated muscle and bony involvement. Results showed reproducible patterns of lacerations on the forehead, bilateral superior orbital rim, nose, perimaxillary region, and chin. Six of 19 cadaver faces were undermined prior to blunt trauma to determine the effects of subcutaneous attachments on laceration patterns. Results showed no consistent difference in laceration patterns between undermined skin and intact skin. Our findings suggest that in response to blunt trauma, the skin breaks along selected lines of least resistance that closely parallel cleavage lines of the face and that the patterns of laceration generated are associated with inherent structural and biomechanical properties of the skin, independent of subcutaneous attachments. Blunt trauma lacerations to the face therefore may occur in a consistent and reproducible manner and may be subject to classification. C1 UNIV MARYLAND,SHOCK TRAUMA UNIT,DEPT PLAST SURG,BALTIMORE,MD 21201. JOHNS HOPKINS UNIV,SCH MED,DIV PLAST & RECONSTRUCT SURG,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,PLAST & RECONSTRUCT SURG SERV,BALTIMORE,MD. NR 12 TC 8 Z9 9 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD MAY PY 1997 VL 99 IS 6 BP 1544 EP 1554 DI 10.1097/00006534-199705000-00012 PG 11 WC Surgery SC Surgery GA WW902 UT WOS:A1997WW90200012 PM 9145122 ER PT J AU McLeod, DG AF McLeod, DG TI Restate cancer in African-American men - Response SO PROSTATE LA English DT Editorial Material C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP McLeod, DG (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0270-4137 J9 PROSTATE JI Prostate PD MAY 1 PY 1997 VL 31 IS 2 BP 142 EP 142 PG 1 WC Endocrinology & Metabolism; Urology & Nephrology SC Endocrinology & Metabolism; Urology & Nephrology GA WW196 UT WOS:A1997WW19600011 ER PT J AU Wilson, DR Wirtz, RA Finlay, BB AF Wilson, DR Wirtz, RA Finlay, BB TI Recognition of phage-expressed peptides containing Asx-Pro sequences by monoclonal antibodies produced against Plasmodium falciparum circumsporozoite protein SO PROTEIN ENGINEERING LA English DT Article DE antibody-antigen recognition; circumsporozoite protein; malaria; phage display; protein conformation ID SYNTHETIC PEPTIDES; MALARIA PARASITE; IMMUNODOMINANT EPITOPES; VACCINE DEVELOPMENT; ELISA DEVELOPMENT; GENE CLONING; BLOOD STAGES; ANKA CLONE; SPOROZOITES; VIVAX AB The immunodominant region of the Plasmodium falciparum circumsporozoite protein is comprised mainly of a series of tetrapeptide repeats that can, depending on the starting cadence chosen, be described as (NANP)(n), (ANPN)(n), (NPNA)(n) or (PNAN)(n) in one-letter amino acid code, Data from several studies suggest that the NPNA cadence alone is structurally correct, in that each NPNA tetrapeptide effectively forms a structural unit initiated by an Asx-Pro turn, To explore this idea further and to assess the immunological relevance of peptide conformation as it relates to the cadence of these tetrapeptide repeats, we used ELISA to compare the abilities of monoclonal antibodies (MAbs) produced against P.falciparum sporozoites to recognize repeat-related heptapeptides expressed on the surface of filamentous bacteriophage. Having included representatives of both NANP and NPNA cadences and other peptides in which the number and location of Asx-Pro sequences varied, we provide evidence that Asx-Pro sequences play an important role in peptide conformation and antibody recognition, that peptide conformation is influenced by the cadence of the tetrapeptide repeats and that peptide conformation is important to the abilities of these MAbs to recognize their epitopes. C1 UNIV BRITISH COLUMBIA,BIOTECHNOL LAB,VANCOUVER,BC V6T 1W5,CANADA. UNIV BRITISH COLUMBIA,DEPT MICROBIOL & IMMUNOL,VANCOUVER,BC V6T 1W5,CANADA. UNIV BRITISH COLUMBIA,DEPT BIOCHEM & MOL BIOL,VANCOUVER,BC V6T 1W5,CANADA. WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC. NR 56 TC 3 Z9 3 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD, ENGLAND OX2 6DP SN 0269-2139 J9 PROTEIN ENG JI Protein Eng. PD MAY PY 1997 VL 10 IS 5 BP 531 EP 540 DI 10.1093/protein/10.5.531 PG 10 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA XF720 UT WOS:A1997XF72000009 PM 9215571 ER PT J AU Labbate, LA Doyle, ME AF Labbate, LA Doyle, ME TI Recidivism in major depressive disorder SO PSYCHOTHERAPY AND PSYCHOSOMATICS LA English DT Article; Proceedings Paper CT 149th Annual Meeting of the American-Psychiatric-Association CY MAY 04-09, 1996 CL NEW YORK, NY SP Amer Psychiat Assoc DE major depressive disorder; inpatients; recidivism; personality disorder; ECT ID PROSPECTIVE FOLLOW-UP; PERSONALITY-DISORDER; COMORBIDITY; CHRONICITY; STATE AB Background: While recidivism has been well studied in psychotic disorders, little has specifically been done to determine what differences exist between patients admitted multiple times compared with once for major depressive disorder (MDD). Method: The records of patients admitted with MDD to a large military medical center were reviewed during the years 1991-1995. Recidivists were 46 consecutive patients admitted three or more times during the period. The comparison sample was 50 consecutive patients admitted for the first time in 1993 without subsequent admission to our hospital. Patient groups were compared for age, gender, comorbidity, and the presence of medical conditions contributing to their admission. Results: Repeat hospital admissions for MDD were common. Recidivists were more likely to be older, suffer recurrent depression, receive a personality disorder diagnosis, receive ECT or have a medical condition contributing to their admission, than patients admitted once. Alcohol use disorders or other Axis I disorders did not predict recidivism. Conclusions: For some patients the morbidity of MDD in the form of frequent admissions is considerable, perhaps as severe as for patients with psychotic disorders. Frequent hospitalizations may result from recurrent MDD with or without personality disorder. C1 MED UNIV S CAROLINA,DEPT PSYCHIAT & BEHAV SCI,CHARLESTON,SC 29425. WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307. RP Labbate, LA (reprint author), VET ADM MED CTR,MENTAL HLTH SERV 116,109 BEE ST,CHARLESTON,SC 29401, USA. NR 23 TC 23 Z9 24 U1 1 U2 1 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0033-3190 J9 PSYCHOTHER PSYCHOSOM JI Psychother. Psychosom. PD MAY-JUN PY 1997 VL 66 IS 3 BP 145 EP 149 PG 5 WC Psychiatry; Psychology SC Psychiatry; Psychology GA XA128 UT WOS:A1997XA12800006 PM 9176908 ER PT J AU Beltran, J Rosenberg, ZS Chandnani, VP Cuomo, F Beltran, S Rokito, A AF Beltran, J Rosenberg, ZS Chandnani, VP Cuomo, F Beltran, S Rokito, A TI Glenohumeral instability: Evaluation with MR arthrography SO RADIOGRAPHICS LA English DT Article DE gadolinium; shoulder, anatomy; shoulder, arthrography; shoulder, dislocation; shoulder, injuries; shoulder, MR ID GLENOID-LABRUM; LIGAMENTOUS COMPLEX; CONTRAST MATERIAL; SLAP INJURIES; SHOULDER; LESION; TEARS AB Magnetic resonance arthrography is superior to other imaging techniques in evaluation of the glenohumeral joint, Normal variants that can be diagnostic pitfalls include the anterosuperior sublabral foramen, the Buford complex, a:nd hyaline cartilage under the labrum, Anteroinferior dislocation is the most frequent cause of anterior glenohumeral instability and produces a constellation of lesions (anteroinferior labral tear, classic and osseous Bankart lesions, Hill-Sachs lesion), Variants of anteroinferior labral tears include anterior labroligamentous periosteal sleeve avulsion and glenoid labral articular disruption, Anterior glenohumeral instability can also involve tears of the anterior or anterosuperior labrum or the glenohumeral ligaments, Posterior glenohumeral instability can involve a posterior labral tear; posterior capsular stripping or laxity; fracture, erosion, or sclerosis and ectopic ossification of the posterior glenoid fossa; reverse Hill-Sachs lesion; McLaughlin fracture; or posterosuperior glenoid impingement. Superior labral anterior and posterior lesions involve the superior labrum with varying degrees of biceps tendon involvement. C1 NYU,SCH MED,DEPT ORTHOPED SURG,NEW YORK,NY 10003. NYU,SCH MED,HOSP JOINT DIS,INST ORTHOPED,NEW YORK,NY 10003. TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859. RP Beltran, J (reprint author), NYU,SCH MED,DEPT RADIOL,301 E 17TH ST,NEW YORK,NY 10003, USA. NR 24 TC 89 Z9 90 U1 0 U2 3 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD MAY-JUN PY 1997 VL 17 IS 3 BP 657 EP 673 PG 17 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA WY172 UT WOS:A1997WY17200012 PM 9153704 ER PT J AU Bao, JZ AF Bao, JZ TI Picosecond domain electromagnetic pulse measurements in an exposure facility: An error compensation routine using deconvolution techniques SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article AB This article presents a two-step deconvolution routine to compensate for the measurement distortions of transient electrical fields in the picosecond domain in an electromagnetic pulse exposure facility. Because of the low-pass nature of connection cables and the limited bandwidth of a transient digitizer (Tektronix SCD 5000), the measured signal is a distorted output of D-dot (dD/dt, where D is the electric displacement) sensors. An empirical transfer function of the cable-digitizer system was evaluated using a reference impulse generated by a picosecond pulse generator. The reference impulse was injected into the connection cable at the D-dot sensor end and measured with the SCD 5000 while the cable was kept in the same position as for making D-dot measurements to ensure an in-position compensation. Two types of asymptotic conical dipole (ACD) D-dot sensors were utilized as the electrical field sensing devices: an axial model ACD-1(A) and a radial model ACD-1(R). Due to its right-angle structures, the ACD-1(R) gives a different output from that of ACD-1(A) to the same pulse, especially to the fast leading edge. The right-angle bends in ACD-1(R) cause reflections of a sensed signal in the sensor. To correct the errors due to the reflections, the impulse response of the ACD-1(R) D-dot sensor was proposed as a summation of the delta function and the parameters were determined with a pulse measurement using the ACD-1(A) D-dot sensor and an optimization procedure with the Levenberg-Marguardt algorithm. With this routine the measurement accuracy for the electrical pulse in picosecond domain has been improved significantly. C1 USA,MED RES DETACHMENT,BROOKS AFB,TX 78235. RP Bao, JZ (reprint author), MCKESSON BIOSERV,BROOKS AFB,TX 78235, USA. NR 23 TC 10 Z9 10 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD MAY PY 1997 VL 68 IS 5 BP 2221 EP 2227 DI 10.1063/1.1148073 PG 7 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA WZ517 UT WOS:A1997WZ51700049 ER PT J AU Hilton, JD AF Hilton, JD TI Corps dredging program sees changes in new fiscal year SO SEA TECHNOLOGY LA English DT Article RP Hilton, JD (reprint author), USA,CORPS ENGINEERS,DREDGING & NAVIGAT BRANCH,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COMPASS PUBL INC PI ARLINGTON PA SUITE 1000 1117 N 19 ST, ARLINGTON, VA 22209 SN 0093-3651 J9 SEA TECHNOL JI Sea Technol. PD MAY PY 1997 VL 38 IS 5 BP 54 EP 55 PG 2 WC Engineering, Ocean SC Engineering GA XA877 UT WOS:A1997XA87700008 ER PT J AU Gibson, PW Charmchi, M AF Gibson, PW Charmchi, M TI Coupled heat and mass transfer through hygroscopic porous materials - Application to clothing layers SO SEN-I GAKKAISHI LA English DT Article ID MODEL; DIFFUSION; MOISTURE; FABRICS; WOOL AB A comprehensive numerical model developed for the coupled transport of energy and mass through porous hygroscopic materials was integrated with an existing human thermal physiology model to provide appropriate boundary conditions for the clothing model. The human thermal control model provides skin temperature, core temperature, skin heat flux, and water vapor flux, along with liquid water accumulation at the skin surface. The integrated model couples the dynamic behavior of the clothing system to the human physiology of heat regulation. This model provided the opportunity to systematically examine a number of clothing parameters, which are usually not included in steady-state thermal physiology studies, and to evaluate their potential importance under various conditions of human work rates and environmental conditions. C1 USA, CTR RES DEV & ENGN, NATICK, MA 01760 USA. UNIV MASSACHUSETTS, LOWELL, MA 01854 USA. RI Gibson, Phillip/D-2398-2010 OI Gibson, Phillip/0000-0002-6172-4438 NR 24 TC 10 Z9 10 U1 0 U2 5 PU SOC FIBER SCIENCE TECHNOLOGY PI TOKYO PA KAMIOSAKI 3-3-9-208, SHINAGAWA-KU, TOKYO, 141-0025, JAPAN SN 0037-9875 J9 SEN-I GAKKAISHI JI Sen-I Gakkaishi PD MAY PY 1997 VL 53 IS 5 BP 183 EP 194 PG 12 WC Materials Science, Textiles; Polymer Science SC Materials Science; Polymer Science GA XJ349 UT WOS:A1997XJ34900006 ER PT J AU Petzold, LR Ren, YH Maly, T AF Petzold, LR Ren, YH Maly, T TI Regularization of higher-index differential-algebraic equations with rank-deficient constraints SO SIAM JOURNAL ON SCIENTIFIC COMPUTING LA English DT Article DE constrained dynamics; multibody systems; differential-algebraic equations; regularization; kinematic singularity; Baumgarte stabilization ID NUMERICAL-SOLUTION; DYNAMICS; STABILITY; SYSTEMS AB In this paper we present several regularizations for higher-index differential-algebraic equations with rank-deficient or singular constraints. These types of problems arise, for example, in the solution of constrained mechanical systems, when a mechanism's trajectory passes through or near a kinematic singularity. We derive a class of regularizations for these problems which is based on minimization of the norm of the constraints. The new regularizations are analogous to trust-region methods of numerical optimization. We give convergence results for the regularizations and present some numerical experiments which illustrate their effectiveness. C1 UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. UNIV BATH, SCH MATH SCI, BATH BA2 7AY, AVON, ENGLAND. FRANKENDATA USA, SIEMENS EMPROS POWER SYST CONTROL, BROOKLYN PK, MN 55428 USA. RP UNIV MINNESOTA, DEPT COMP SCI, MINNEAPOLIS, MN 55455 USA. NR 31 TC 14 Z9 14 U1 1 U2 1 PU SIAM PUBLICATIONS PI PHILADELPHIA PA 3600 UNIV CITY SCIENCE CENTER, PHILADELPHIA, PA 19104-2688 USA SN 1064-8275 EI 1095-7197 J9 SIAM J SCI COMPUT JI SIAM J. Sci. Comput. PD MAY PY 1997 VL 18 IS 3 BP 753 EP 774 DI 10.1137/S1064827593276041 PG 22 WC Mathematics, Applied SC Mathematics GA WW816 UT WOS:A1997WW81600006 ER PT J AU Zavada, JM Wilson, RG Ren, F Pearton, SJ Davis, RF AF Zavada, JM Wilson, RG Ren, F Pearton, SJ Davis, RF TI Hydrogen incorporation and its temperature stability in SiC crystals SO SOLID-STATE ELECTRONICS LA English DT Article ID CARBIDE; DEVICES; POWER; EPITAXY; GAN; ALN; INN AB SiC is an important wide bandgap semiconductor material with use in high temperature electronics and as a substrate for III-V nitride epitaxial growth. In several processing stages that are required for such applications, atomic hydrogen may be introduced into the SiC material. Since atomic hydrogen is able to passivate shallow donors or accepters, device performance may be affected. Here we report on the incorporation of hydrogen and its thermal stability in 6H-SiC crystals. Hydrogen was introduced either through ion implantation or by plasma treatment. Implantation of H-2 was performed at an energy of 100 keV to a fluence of 2 x 10(15) cm(-2). In the as-implanted sample, a classical implant profile with a H-2 density of about 10(20) cm(-3) at a depth of about 0.75 mu m was obtained using secondary ion mass spectrometry (SIMS). Other samples were exposed to a H-2 plasma for 30 min at 300 degrees C; While the SIMS profiles of the plasma treated samples had a H-2 peak density at the surface of about 10(20) cm(-3), the background level of H-2 was reached in less than 0.1 mu m. Samples were furnace annealed under flowing N at temperatures up to 1000 degrees C. In contrast with Si and III-V materials, there was no significant redistribution of H-2 in the implanted SiC crystal with annealing. For plasma treated samples, annealing led to a significant reduction of H-2. (C) 1997 Elsevier Science Ltd. C1 HUGHES RES LABS,MALIBU,CA 90265. AT&T BELL LABS,LUCENT TECHNOL,MURRAY HILL,NJ 07974. UNIV FLORIDA,GAINESVILLE,FL 32611. N CAROLINA STATE UNIV,RALEIGH,NC 27695. RP Zavada, JM (reprint author), USA,RES OFF,RES TRIANGLE PK,NC 27709, USA. RI Davis, Robert/A-9376-2011 OI Davis, Robert/0000-0002-4437-0885 NR 17 TC 8 Z9 9 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD MAY PY 1997 VL 41 IS 5 BP 677 EP 679 DI 10.1016/S0038-1101(96)00249-3 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA WZ800 UT WOS:A1997WZ80000004 ER PT J AU Gessner, BD Bell, P Doucette, GJ Moczydlowski, E Poli, MA VanDolah, F Hall, S AF Gessner, BD Bell, P Doucette, GJ Moczydlowski, E Poli, MA VanDolah, F Hall, S TI Hypertension and identification of toxin in human urine and serum following a cluster of mussel-associated paralytic shellfish poisoning outbreaks SO TOXICON LA English DT Article ID SAXITOXIN-BINDING PROTEIN; SODIUM-CHANNELS; MUSCLE; TETRODOTOXIN; BULLFROG; RAT; SAXIPHILIN; CHEMISTRY; CHILE AB Following four outbreaks of paralytic shellfish poisoning on Kodiak Island, Alaska, during 1994, medical records of ill persons were reviewed and interviews were conducted, Urine and serum specimens were analyzed at three independent laboratories using four different saxitoxin binding assays, High-performance liquid chromatography was used to determine the presence of specific toxin congeners, Among 11 ill persons, three required mechanical ventilation and one died, Mean peak systolic and diastolic blood pressure measurements were 172 (range 128-247) and 102 (range 78-165) mmHg, respectively, and blood pressure measurements corresponded with ingested toxin dose, All four different laboratory methodologies detected toxin in serum at 2.8-47 nM during acute illness and toxin in urine at 65-372 nM after acute symptom resolution. The composition of specific paralytic shellfish poisons differed between mussels and human biological specimens, suggesting that human metabolism of toxins had occurred. The results of this study indicate that saxitoxin analogues may cause severe hypertension. In addition, we demonstrate that saxitoxins can be detected in human biological specimens, that nanomolar serum toxin levels may cause serious illness and that human metabolism of toxin may occur. Clearance of paralytic shellfish poisons from serum was evident within 24 hr and urine was identified as a major route of toxin excretion in humans. (C) 1997 Elsevier Science Ltd. C1 YALE UNIV, SCH MED, DEPT PHARMACOL, NEW HAVEN, CT 06520 USA. YALE UNIV, SCH MED, DEPT CELLULAR & MOL PHYSIOL, NEW HAVEN, CT 06520 USA. US DEPT COMMERCE, NOAA, SE FISHERIES SCI CTR, NATL MARINE FISHERIES SERV, CHARLESTON, SC 29422 USA. USA, MED RES INST INFECT DIS, FT DETRICK, MD 21702 USA. US FDA, WASHINGTON, DC 20204 USA. RP Gessner, BD (reprint author), ALASKA DIV PUBL HLTH, 1231 GAMBELL ST, 2ND FLOOR, ANCHORAGE, AK 99501 USA. RI Moczydlowski, Edward/A-9304-2009; Moczydlowski, Edward/D-1734-2013; Doucette, Gregory/M-3283-2013 NR 35 TC 61 Z9 65 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD MAY PY 1997 VL 35 IS 5 BP 711 EP 722 DI 10.1016/S0041-0101(96)00154-7 PG 12 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA XE623 UT WOS:A1997XE62300010 PM 9203296 ER PT J AU Poli, MA Lewis, RJ Dickey, RW Musser, SM Buckner, CA Carpenter, LG AF Poli, MA Lewis, RJ Dickey, RW Musser, SM Buckner, CA Carpenter, LG TI Identification of Caribbean ciguatoxins as the cause of an outbreak of fish poisoning among US soldiers in Haiti SO TOXICON LA English DT Article ID PURIFICATION; CIGUATERA AB On 24 February 1995, six U.S. soldiers serving with the Multinational Force in Haiti became ill after eating a locally caught fish identified as the greater amberjack Seriola dumerili. The victims presented with nausea, vomiting, watery diarrhea and abdominal cramps 5-8 hr after consumption, Also present in some victims were numbness in the extremities or perioral region, bradycardia and scalp paresthesia. Patients were treated with i,v. hydration therapy and antiemetics. All recovered without sequelae over the course of 1-3 months. A portion of the cooked fish was obtained for analysis. A semipurified lipid extract was prepared according to standard methods and analyzed for the presence of Na+ channel site 5 binding activity using a brevetoxin receptor binding assay. By this assay, the fish sample contained the equivalent of approximately 20 ng Caribbean ciguatoxin/g flesh. The presence of the major Caribbean ciguatoxin (C-CTX-1) was confirmed by liquid chromatography-mass spectrometry. Using the receptor binding assay to monitor activity in TSK and PRP-1 column fractions, two minor toxins were detected in addition to C-CTX-1. One of these minor toxins was more polar, and the other less polar, than C-CTX-1. These data provide firm evidence that a family of C-CTX-1 is responsible for ciguatera in the Caribbean. Published by Elsevier Science Ltd. C1 UNIV QUEENSLAND,QUEENSLAND DEPT PRIMARY IND,BRISBANE,QLD,AUSTRALIA. US FDA,GULF COAST RES LAB,DAUPHIN ISL,AL 36528. US FDA,CTR FOOD SAFETY & APPL NUTR,WASHINGTON,DC 20204. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. USA,INST SURG RES,SAN ANTONIO,TX 78234. RP Poli, MA (reprint author), USA,MED RES INST INFECT DIS,TOXINOL DIV,FT DETRICK,MD 21702, USA. RI Lewis, Richard/E-8674-2013 OI Lewis, Richard/0000-0003-3470-923X NR 17 TC 63 Z9 69 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD MAY PY 1997 VL 35 IS 5 BP 733 EP 741 DI 10.1016/S0041-0101(96)00166-3 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA XE623 UT WOS:A1997XE62300012 PM 9203298 ER PT J AU Thompson, IM Rozanski, TA Foley, JP Harris, M AF Thompson, IM Rozanski, TA Foley, JP Harris, M TI Facilitated radical perineal prostatectomy with the Brooke bookwalter retractor blade SO UROLOGY LA English DT Article AB With the resurgent interest in radical perineal prostatectomy, a variety of enhancements have been made to the procedure. We describe herein the use of a retractor blade that allows full mobilization of the seminal vesicles and vasa prior to prostatic apical dissection, thus facilitating bladder neck-sparing radical prostatectomy. This retractor system dramatically improves visualization of the seminal vesicles and prostatic pedicles, allowing a single surgeon to perform this procedure easily. (C) 1997, Elsevier Science Inc. C1 BROOKE ARMY MED CTR,DEPT SURG,UROL SERV,FT SAM HOUSTON,TX 78234. NR 2 TC 4 Z9 4 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD MAY PY 1997 VL 49 IS 5 BP 766 EP 767 DI 10.1016/S0090-4295(97)00061-7 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA WW845 UT WOS:A1997WW84500028 PM 9145986 ER PT J AU Francesconi, RP Willis, JS Gaffin, SL Hubbard, RW AF Francesconi, RP Willis, JS Gaffin, SL Hubbard, RW TI On the trail of potassium in heat injury SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Review DE potassium; heat injury; cellular aspects; membrane dynamics; heat stroke; hypokalemia; hyperkalemia ID ENERGY DEPLETION MODEL; ACUTE RENAL-FAILURE; PLASMA-VOLUME; EXERCISE; STROKE; RATS; HEATSTROKE; METABOLISM; SODIUM; RHABDOMYOLYSIS AB In both classical and exertional heatstroke and in various animal models of human heat injury, clinical manifestations have included observations of normokalemia, hyperkalemia, and hypokalemia. This review attempts to address these observations as well as the role of potassium and potassium depletion in heat injury with an emphasis on the integration of information from the level of transmembrane potassium transport mechanisms to systems physiology. Under moderate conditions of passive heat exposure or exercise in the heat, the adaptive capacity of the Na-K pump (Na+-K+ ATPase activity) and cotransport mechanisms can ordinarily accommodate the attendant increased efflux of intracellular K+ and influx of extracellular Na+ to maintain ionic equilibrium. Several factors affecting transmembrane K+ kinetics include protracted K+ deficiency, extreme hyperthermia, dehydration, and excessive exertion. These could elicit reduced membrane potentials and conductance, futile cycling of the Na-K pump with concomitant energy depletion and greatly increased metabolic heat production, reduced arteriolar vasodilation, altered neurotransmitter release, or cell swelling, each of which could contribute to the pathophysiology of heat injury. This review represents a preliminary attempt to link transmembrane K+ pathophysiology with clinical heat injury. C1 UNIV GEORGIA,DEPT CELLULAR BIOL,ATHENS,GA 30602. RP Francesconi, RP (reprint author), USA,ENVIRONM MED RES INST,MIL NUTR & BIOCHEM DIV,NATICK,MA 01760, USA. NR 70 TC 5 Z9 6 U1 0 U2 0 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 1080-6032 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD MAY PY 1997 VL 8 IS 2 BP 105 EP 110 DI 10.1580/1080-6032(1997)008[0105:OTTOPI]2.3.CO;2 PG 6 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA XX426 UT WOS:A1997XX42600009 PM 11990141 ER PT J AU Jackson, JL Gibbons, R Meyer, G Inouye, L AF Jackson, JL Gibbons, R Meyer, G Inouye, L TI The effect of treating herpes zoster with oral acyclovir in preventing postherpetic neuralgia - A meta-analysis SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; INTRAVENOUS ACYCLOVIR; THERAPY; OPHTHALMICUS AB Background: Herpes tester is a common affliction in older patients, with up to 15% experiencing some residual pain in the distribution of the rash several months after healing. Despite numerous randomized clinical trials, the effect of treating herpes tester with oral acyclovir in preventing postherpetic neuralgia remains uncertain because of conflicting results. Methods: Meta-analysis of published randomized clinical trials on the use of acyclovir to prevent postherpetic neuralgia using the fixed-effects model of Peto. Results: Thirty clinical trials of treatment with oral acyclovir in immunocompetent adults were identified. After excluding studies with duplicate data, suboptimal and topical dosing, non-placebo-controlled or nonrandomized designs, and those using intravenous acyclovir, 5 trials were found to be homogeneous and were combined for analysis. From these trials, the summary odds ratio for the incidence of ''any pain'' in the distribution of rash at 6 months in adults treated with acyclovir was 0.54 (95% confidence interval, 0.36-0.81). Conclusion: Treatment of herpes tester with 800 mg/d of oral acyclovir within 72 hours of rash onset may reduce the incidence of residual pain at 6 months by 46% in immunocompetent adults. C1 MADIGAN ARMY MED CTR,DEPT MED,TACOMA,WA 98431. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR,BETHESDA,MD 20814. PORTSMOUTH NAVAL MED CTR,DEPT MED,PORTSMOUTH,VA. NR 52 TC 110 Z9 113 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD APR 28 PY 1997 VL 157 IS 8 BP 909 EP 912 DI 10.1001/archinte.157.8.909 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA WV850 UT WOS:A1997WV85000009 PM 9129551 ER PT J AU OBrien, TR Winkler, C Dean, M Nelson, JAE Carrington, M Michael, NL White, GC AF OBrien, TR Winkler, C Dean, M Nelson, JAE Carrington, M Michael, NL White, GC TI HIV-1 infection in a man homozygous for CCR5 Delta 32 SO LANCET LA English DT Article C1 NCI,LAB GENOM DIVERS,US PHS,US DEPT HHS,BETHESDA,MD 20852. WALTER REED ARMY INST RES,DEPT RETROVIROL,ROCKVILLE,MD. UNIV N CAROLINA,DIV HEMATOL & ONCOL,CAPEL HILL SCH MED,CHAPEL HILL,NC. UNIV N CAROLINA,DIV HEMATOL & ONCOL,SCH MED,CHAPEL HILL,NC. UNIV N CAROLINA,LINEBERGER COMPREHENS CANC CTR,SCH MED,CHAPEL HILL,NC. RP OBrien, TR (reprint author), NCI,VIRAL EPIDEMIOL BRANCH,US PHS,US DEPT HHS,BETHESDA,MD 20852, USA. RI Dean, Michael/G-8172-2012 OI Dean, Michael/0000-0003-2234-0631 NR 5 TC 213 Z9 216 U1 1 U2 1 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD APR 26 PY 1997 VL 349 IS 9060 BP 1219 EP 1219 DI 10.1016/S0140-6736(97)24017-1 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA WW717 UT WOS:A1997WW71700013 PM 9130945 ER PT J AU Lin, AJ Zikry, AB Kyle, DE AF Lin, AJ Zikry, AB Kyle, DE TI Antimalarial activity of new dihydroartemisinin derivatives .7. 4-(p-substituted phenyl)-4(R or S)-[10(alpha or beta)-dihydroartemisininoxy]butyric acids SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID PLASMODIUM-FALCIPARUM; HEPATIC-METABOLISM; ARTEMISININ DRUGS; INVITRO; ANALOGS; QINGHAOSU; ARTEETHER AB To search for water soluble dihydroartemisinin derivatives with higher efficacy and longer plasma half-life than artesunic or artelinic acid, a series of new stereoisomers of 4-(p-substituted phenyl)-4(R or S)-[10(alpha or beta)-dihydroartemisininoxy]butyric acids were synthesized as new potential antimalarial agents. Two approaches were taken in the design of these new molecules in an attempt to (a) increase the lipophilicity of the molecule and (b) decrease the rate of oxidative dealkylation of the target compounds. The new compounds showed a 2-10-fold increase in in vitro antimalarial activity against D-6 and W-2 clones of Plasmodium falciparum than artemisinin or artelinic acid. R-diastereomers are, in general, more potent than the corresponding S-diastereomers, p-Chlorophenyl and p-bromophenyl derivatives showed in vivo oral antimalarial activity against P. berghei (with 3/8 cured) superior to that of artelinic acid (1/8 cured), whereas p-fluorophenyl and p-methoxyphenyl analogs demonstrated activity only comparable (1/8 cured) to that of artelinic acid at the same dosage level (64 mg/kg twice a day). The in vivo antimalarial activity of these new compounds correlates with their SD50 (50% parasitemia suppression dose), The biological results suggested that an electronic effect, besides the lipophylicity, may play a role in determining the efficacy of this class of compounds. RP Lin, AJ (reprint author), WALTER REED ARMY MED CTR,INST RES,DIV EXPT THERAPEUT,WASHINGTON,DC 20307, USA. NR 37 TC 46 Z9 48 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD APR 25 PY 1997 VL 40 IS 9 BP 1396 EP 1400 DI 10.1021/jm9607919 PG 5 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA WW016 UT WOS:A1997WW01600010 PM 9135037 ER PT J AU Wu, X Hommerich, U Mackenzie, JD Abernathy, CR Pearton, SJ Schwartz, RN Wilson, RG Zavada, JM AF Wu, X Hommerich, U Mackenzie, JD Abernathy, CR Pearton, SJ Schwartz, RN Wilson, RG Zavada, JM TI Direct and indirect excitation of Er3+ ions in Er:AlN SO APPLIED PHYSICS LETTERS LA English DT Article ID IMPLANTED GAN; PHOTOLUMINESCENCE; LUMINESCENCE AB Photoluminescence (PL) excitation and time-resolved PL measurements were conducted on erbium doped AlN. The Er:AlN film was grown by metal organic molecular beam epitaxy with a solid Er effusion source. The resulting Er concentration was 2-5X10(19) Er/cm(3). Photoluminescence excitation measurements revealed that Er3+ in Er:AlN can be excited either through direct optical pumping into Er3+ 4f levels or through an indirect carrier-mediated process. With respect to these two Er3+ excitation schemes, distinct Er3+ PL decay patterns were observed. The Er3+ PL excited by direct optical excitation was longer lived than that excited via a carrier-mediated process, Time-resolved PL measurements support that at least two classes of Er3+ PL centers exist in Er:AlN, and that direct optical excitation of Er3+ 4f levels primarily excites a set of longer-lived Er3+ sites which are not excited through carrier-mediated processes. (C) 1997 American Institute of Physics. C1 UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611. HUGHES RES LABS,MALIBU,CA 90265. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Wu, X (reprint author), HAMPTON UNIV,DEPT PHYS,RES CTR OPT PHYS,HAMPTON,VA 23668, USA. OI Wu, Xinglong/0000-0002-2787-3069 NR 11 TC 42 Z9 43 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 21 PY 1997 VL 70 IS 16 BP 2126 EP 2128 DI 10.1063/1.118951 PG 3 WC Physics, Applied SC Physics GA WU601 UT WOS:A1997WU60100021 ER PT J AU Rosen, JM Pinnick, RG Garvey, DM AF Rosen, JM Pinnick, RG Garvey, DM TI Nephelometer optical response model for the interpretation of atmospheric aerosol measurements SO APPLIED OPTICS LA English DT Article DE nephelometer; nephelometer response; aerosol; aerosol scattering; size distribution; optical model ID SCATTERING AB A numerical model evaluating the response of a typical integrating nephelometer is described. The model incorporates the actual scattering geometry as well as the effects of a finite light source, detector size, and a nonideal Lambertian diffuser. An angular scattering weighting function is introduced to provide a tractable approach in numerical calculations and easy application. Using established size distribution ensembles associated with a few representative aerosol types, we compare the calculated response of a real nephelometer with that of an ideal. or perfect, nephelometer. The results indicate that, frequently, the nephelometer-produced aerosol-scattering coefficient is of the order of 10-20% too small; but for some naturally occurring aerosols, the difference may be as large as 40-50%. For a multiple-wavelength nephelometer, the response model can be employed to estimate the expected error in the aerosol-scattering coefficients directly from the measurements themselves. (C) 1997 Optical Society of America. C1 ARMY RES LAB,ADELPHI,MD 20783. RP Rosen, JM (reprint author), UNIV WYOMING,DEPT PHYS & ASTRON,LARAMIE,WY 82071, USA. NR 14 TC 13 Z9 13 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD APR 20 PY 1997 VL 36 IS 12 BP 2642 EP 2649 DI 10.1364/AO.36.002642 PG 8 WC Optics SC Optics GA WU839 UT WOS:A1997WU83900032 PM 18253255 ER PT J AU Gibson, P Charmchi, M AF Gibson, P Charmchi, M TI The use of volume-averaging techniques to predict temperature transients due to water vapor sorption in hygroscopic porous polymer materials SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE diffusion; sorption; water vapor; porous materials; textiles ID HEAT; MOISTURE; MODEL; DIFFUSION; MEDIA; WOOL AB Volume-averaging techniques developed for modeling drying processes in porous materials offer a convenient framework for analyzing vapor sorption in porous hygroscopic polymeric materials. Because of the large temperature changes associated with water vapor sorption in these materials (from 10 degrees to 20 degrees C), sorption/diffusion processes are best characterized through the coupled differential equations describing both the transport of energy and mass through the porous structure. Experimental and numerical results are compared for a variety of natural and man-made porous polymeric materials (textiles) using the volume-averaging technique. Boundary heat and mass transfer coefficients and assumptions about thermal radiative properties of the experimental apparatus are shown to influence results obtained with the numerical solution method. (C) 1997 John Wiley & Sons, Inc. C1 UNIV LOWELL, DEPT MECH ENGN, LOWELL, MA 01854 USA. RP Gibson, P (reprint author), USA, NATICK RES DEV & ENGN CTR, NATICK, MA 01760 USA. RI Gibson, Phillip/D-2398-2010 OI Gibson, Phillip/0000-0002-6172-4438 NR 28 TC 22 Z9 22 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD APR 18 PY 1997 VL 64 IS 3 BP 493 EP 505 PG 13 WC Polymer Science SC Polymer Science GA WP836 UT WOS:A1997WP83600006 ER PT J AU McNesby, KL Coffey, CS AF McNesby, KL Coffey, CS TI Spectroscopic determination of impact sensitivities of explosives SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID HOT-SPOT FORMATION; INITIATION; PROPELLANT; MODEL AB A simple theory is developed which predicts impact sensitivities in crystalline explosives from vibrational spectra measured at room temperature. The theory uses Raman spectra of energetic materials to construct vibrational energy level diagrams, which are then used as input for a model designed to calculate the rate of energy transfer from phonon and near-phonon vibrational energy levels to higher energy vibrational levels, Energy transfer rates are determined using Fermi's Golden Rule and results from simple theories of near-resonant energy transfer. The application of the theory and model, using Raman spectra of seven different neat explosive samples, gives results in good agreement with results of drop weight impact tests. C1 USN,CTR SURFACE WARFARE,SILVER SPRING,MD 20903. RP McNesby, KL (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 29 TC 75 Z9 81 U1 2 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 1089-5647 J9 J PHYS CHEM B JI J. Phys. Chem. B PD APR 17 PY 1997 VL 101 IS 16 BP 3097 EP 3104 DI 10.1021/jp961771l PG 8 WC Chemistry, Physical SC Chemistry GA WU630 UT WOS:A1997WU63000013 ER PT J AU Madhukar, S Aggarwal, S Dhote, AM Ramesh, R Krishnan, A Keeble, D Poindexter, E AF Madhukar, S Aggarwal, S Dhote, AM Ramesh, R Krishnan, A Keeble, D Poindexter, E TI Effect of oxygen stoichiometry on the electrical properties of La0.5Sr0.5CoO3 electrodes SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID NONSTOICHIOMETRY; COEFFICIENT; OXIDES AB We report on the metal-insulator transition of La0.5Sr0.5CoO3 thin films deposited by pulsed laser ablation on LaAlO3 substrates. The films were cooled in oxygen partial pressures between 760 and 10(-5) Ton and electrical resistivity of the films was measured as a function of cooling oxygen pressure. La0.5Sr0.5CoO3 films changed from metallic to insulating behavior depending on their oxygen content. A defect model has been proposed to explain this transition and the change in conductivity is related to the change in the oxidation state of the cobalt ions. The model explains the relationship between oxygen partial pressure and electrical conductivity in La0.5Sr0.5CoO3, which describes the experimental dependence reasonably well. Positron annihilation studies were also done on the same set of samples and the S parameter was seen to increase by 8% from a fully oxygenated sample to a sample cooled in 10(-5) Torr. (C) 1997 American Institute of Physics. C1 MICHIGAN TECHNOL UNIV,DEPT PHYS,HOUGHTON,MI 49931. UNIV DUNDEE,CARNEGIE LAB PHYS,DUNDEE DD1 4HN,SCOTLAND. USA,RES LAB,FT MONMOUTH,NJ 07703. RP Madhukar, S (reprint author), UNIV MARYLAND,DEPT MAT & NUCL ENGN,COLLEGE PK,MD 20742, USA. RI Keeble, David /C-6633-2012 OI Keeble, David /0000-0002-5378-799X NR 19 TC 90 Z9 90 U1 1 U2 21 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 15 PY 1997 VL 81 IS 8 BP 3543 EP 3547 DI 10.1063/1.364991 PN 1 PG 5 WC Physics, Applied SC Physics GA WV363 UT WOS:A1997WV36300030 ER PT J AU OConnor, CJ Buisson, YSL Li, S Banerjee, S Premchandran, R Baumgartner, T John, VT McPherson, GL Akkara, JA Kaplan, DL AF OConnor, CJ Buisson, YSL Li, S Banerjee, S Premchandran, R Baumgartner, T John, VT McPherson, GL Akkara, JA Kaplan, DL TI Ferrite synthesis in microstructured media: Template effects and magnetic properties SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 41st Annual Conference on Magnetism and Magnetic Materials CY NOV 12-15, 1996 CL ATLANTA, GA SP Amer Inst Phys ID IRON-OXIDES; PARTICLES AB Inverse micelles and organogels provide novel environments to synthesize ferrite particles. The fluid microstructure provides a template for the synthesis. Our experiments with ferrite synthesis in inverse micelles indicate the formation of superparamagnetic nanoparticles. Of interest is the encapsulation of these particles in polymer microspheres. The encapsulation is done using simple polymer precipitation in the micellar nonsolvent. The process results in a polymer-ferrite composite exhibiting supermagnetism. Low temperature spin glass properties of the composite are characterized through SQUID measurements. These composites have a superparamagnetic blocking temperature of 16 K and follow Curie-Weiss law at temperatures above 60 K with the fitted parameters: C = 0.941 emu/g K, theta=-287 K, and TIP=0.0001 emu/g. Since the polymer used is polyphenol, a highly functionalizable material, the composite is well suited for applications in magnetic bioseparations and magnetic coatings. (C) 1997 American Institute of Physics. C1 TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. TULANE UNIV,DEPT CHEM,NEW ORLEANS,LA 70118. USA,SOLDIER SYST COMMAND,NATICK,MA 01760. RP OConnor, CJ (reprint author), UNIV NEW ORLEANS,DEPT CHEM,NEW ORLEANS,LA 70148, USA. RI John, Vijay/G-3747-2010 NR 16 TC 17 Z9 17 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 15 PY 1997 VL 81 IS 8 BP 4741 EP 4743 DI 10.1063/1.365448 PN 2A PG 3 WC Physics, Applied SC Physics GA WV536 UT WOS:A1997WV53600381 ER PT J AU Leupold, HA Potenziani, E Tilak, A AF Leupold, HA Potenziani, E Tilak, A TI Circular free-electron laser structures SO JOURNAL OF APPLIED PHYSICS LA English DT Meeting Abstract C1 USA,RES LAB,FT MONMOUTH,NJ 07703. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD APR 15 PY 1997 VL 81 IS 8 BP 5144 EP 5144 DI 10.1063/1.365150 PN 2B PG 1 WC Physics, Applied SC Physics GA WV537 UT WOS:A1997WV53700156 ER PT J AU Kovacs, A AF Kovacs, A TI Estimating the full-scale flexural and compressive strength of first-year sea ice SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article AB Sea ice salinity, density, and temperature data were used to develop new methods for determining the bulk brine volume and porosity of sea ice flees. Methods for estimating full-thickness ice sheet strength, based on large-scale field tests, are presented. The relationships among bulk sea ice properties, strain rate, and strength are illustrated. A new constitutive equation was developed for predicting the full-thickness horizontal compressive strength sigma(c) Of first-year sea ice as a function of the applied strain rate and bulk porosity in the form sigma(c) = B-2 (epsilon) over dot(1/n) phi(B)(m) where parameters B-2, n, and m are about 2.7 x 10(3), 3, and -1, respectively, and (epsilon) over dot and phi(B) are the ice strain rate and ice flee bulk porosity of sea ice, respectively. An example of the first-year sea ice indentation force against a 90-m-wide structure is given. Estimating sea ice strength based on remote ice conductivity measurements is also discussed conceptually. RP Kovacs, A (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 28 TC 8 Z9 13 U1 0 U2 1 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD APR 15 PY 1997 VL 102 IS C4 BP 8681 EP 8689 DI 10.1029/96JC02738 PG 9 WC Oceanography SC Oceanography GA WU659 UT WOS:A1997WU65900013 ER PT J AU Barth, J AF Barth, J TI Your bank is ripping you off - Mrkvicka,EF SO LIBRARY JOURNAL LA English DT Book Review RP Barth, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 15 PY 1997 VL 122 IS 7 BP 92 EP 93 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA WT910 UT WOS:A1997WT91000132 ER PT J AU Hayduk, MJ Johns, ST Krol, MF Pollock, CR Leavitt, RP AF Hayduk, MJ Johns, ST Krol, MF Pollock, CR Leavitt, RP TI Self-starting passively mode-locked tunable femtosecond Cr4+:YAG laser using a saturable absorber mirror SO OPTICS COMMUNICATIONS LA English DT Article ID GENERATION; DISPERSION; PULSES AB We have demonstrated self-starting, passive mode-locking of a Cr4+:YAG laser using a saturable absorber mirror structure. Highly stable femtosecond pulses tunable from 1488 to 1535 nm were generated with average output powers ranging from 40 to 80 mW. Nearly transform limited pulses of 120 fs duration were obtained at 1488 nm. C1 CORNING INC,CORNING,NY 14831. CORNELL UNIV,SCH ELECT ENGN,ITHACA,NY 14853. USA,RES LAB,ADELPHI,MD 20783. RP Hayduk, MJ (reprint author), OCPA,ROME LAB,PHOTON CTR,25 ELECT PKY,ROME,NY 13441, USA. NR 15 TC 31 Z9 32 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD APR 15 PY 1997 VL 137 IS 1-3 BP 55 EP 58 DI 10.1016/S0030-4018(96)00758-4 PG 4 WC Optics SC Optics GA WQ297 UT WOS:A1997WQ29700013 ER PT J AU RicoHesse, R Harrison, LM Salas, RA Tovar, D Nisalak, A Ramos, C Boshell, J deMesa, MTR Nogueira, RMR daRosa, AT AF RicoHesse, R Harrison, LM Salas, RA Tovar, D Nisalak, A Ramos, C Boshell, J deMesa, MTR Nogueira, RMR daRosa, AT TI Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas SO VIROLOGY LA English DT Article ID AMINO-ACID-SEQUENCES; HEMORRHAGIC-FEVER; MONOCLONAL-ANTIBODIES; NUCLEOTIDE; ENVELOPE; GENE; EPIDEMIC; PROTEINS; STRAINS; RISK AB The recent emergence and spread of dengue hemorrhagic fever in the Americas have been a major source of concern. Efforts to control this disease are dependent on understanding the pathogenicity of dengue viruses and their transmission dynamics. Pathogenicity studies have been hampered by the lack of in vitro or in vivo models of severe dengue disease. Alternatively, molecular epidemiologic studies which associate certain dengue Virus genetic types with severe dengue outbreaks may point to strains with increased pathogenicity. The comparison of nucleotide sequences (240 bp) from the E/NS1 gene region of the dengue virus genome has been shown to reflect evolutionary relationships and geographic origins of dengue virus strains. This approach was used to demonstrate an association between the introduction of two distinct genotypes of dengue type 2 virus and the appearance of dengue hemorrhagic fever in the Americas. Phylogenetic analyses suggest that these genotypes originated in Southeast Asia and that they displaced the native, American genotype in at least four countries. Vaccination and other control efforts should therefore be directed at decreasing the transmission of these ''virulent'' genotypes. (C) 1997 Academic Press. C1 YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH,NEW HAVEN,CT 06520. MINIST SALUD,INST NACL HIGIENE RAFAEL RANGEL,CARACAS,VENEZUELA. ARMED FORCES RES INST MED SCI,DEPT VIROL,BANGKOK 10400,THAILAND. CISEI,INST NACL SALUD PUBL,CUERNAVACA,MORELOS,MEXICO. MINIST SALUD,INST NACL SALUD,BOGOTA,COLOMBIA. UNIV VALLE,DEPT MICROBIOL,CALI,COLOMBIA. INST OSWALDO CRUZ,DEPT VIROL,BR-20001 RIO JANEIRO,BRAZIL. FUNDACAO NACL SAUDE,INST EVANDRO CHAGAS,BELEM,PARA,BRAZIL. RI Rico-Hesse, Rebeca/C-5294-2011 OI Rico-Hesse, Rebeca/0000-0001-6216-1000 FU NIAID NIH HHS [AI01124, P01 AI034533] NR 34 TC 388 Z9 406 U1 4 U2 42 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD APR 14 PY 1997 VL 230 IS 2 BP 244 EP 251 DI 10.1006/viro.1997.8504 PG 8 WC Virology SC Virology GA WV204 UT WOS:A1997WV20400011 PM 9143280 ER PT J AU Valdes, JJ AF Valdes, JJ TI Commercial applications of biosensor technology SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD,RT,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 5 EP SCHB PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP187 UT WOS:A1997WP18703726 ER PT J AU Porter, WL Yeomans, WG Grant, DF AF Porter, WL Yeomans, WG Grant, DF TI Interactions of container-derived tin with ascorbic acid and caffeic acid esters in fruit. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 LEXINGTON HIGH SCH,LEXINGTON,MA 02173. USA,NATICK RES DEV & ENGN CTR,SOLDIER SYST COMMAND,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 7 EP AGFD PN 1 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18500008 ER PT J AU Shih, ML Korte, WD Clark, CR AF Shih, ML Korte, WD Clark, CR TI Multicomponent spectroscopic assay for hemoglobin and ferrihemoglobin species in methemoglobin treatment of cyanide poisoning. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 100 EP ANYL PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18500455 ER PT J AU Schneider, JF ONeill, HJ Kimmell, TA Nudell, C Kosco, N AF Schneider, JF ONeill, HJ Kimmell, TA Nudell, C Kosco, N TI Gas chromatography sulfur chemiluminescence detection for the analysis of bis (2-chloroethyl) sulfide SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 ARGONNE NATL LAB,ARGONNE,IL 60439. USA,DUGWAY PROVING GROUND,DUGWAY PROVING GROUND,UT 84022. USA,TEST & EVALUAT COMMAND,ABERDEEN PROVING GROUND,MD 21005. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 146 EP ENVR PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18503176 ER PT J AU Nassar, AF Emery, A Hoffman, L AF Nassar, AF Emery, A Hoffman, L TI Analysis of chemical warfare agent degradation products by capillary electrophoresis and ion chromatography. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 BATTELLE INST,BEL AIR,MD 21015. USA,TREATY LAB,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 147 EP ENVR PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18503177 ER PT J AU Wagner, GW MacIver, BK AF Wagner, GW MacIver, BK TI Degradation and fate of mustard simulants in soil as determined by C-13 MAS NMR. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,ERDEC,ABERDEEN PROVING GROUND,MD 21010. GEOCENTERS INC,GUNPOWDER BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 148 EP GEOC PN 1 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18503588 ER PT J AU Davis, WM Powell, JF Furey, J Thompson, CV Wise, M AF Davis, WM Powell, JF Furey, J Thompson, CV Wise, M TI Rapid subsurface detection of volatile organic compounds in groundwater SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA ENGINEERS,WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. US DOE,OAK RIDGE LAB,DIV CHEM & ANALYT SCI,OAK RIDGE,TN 37231. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 151 EP ENVR PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18503181 ER PT J AU Lushington, GH Chabalowski, CF AF Lushington, GH Chabalowski, CF TI Ab initio studies of physisorption: N2 on graphite. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 169 EP COLL PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18502409 ER PT J AU Ayyagari, MSR AF Ayyagari, MSR TI On molecular interactions in peroxidase catalyzed phenol polymerization: Effect on polymer molecular weight. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,SOLDIER SYST COMMAND,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 175 EP BIOT PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18500768 ER PT J AU Bruno, FF Kaplan, DK Dordick, JS Akkara, JA AF Bruno, FF Kaplan, DK Dordick, JS Akkara, JA TI Selective enzymatic acylation of biopolymers in an organic solvent. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,SOLDIER SYST COMMAND,NATICK,MA 01760. UNIV MASSACHUSETTS,DEPT CHEM,LOWELL,MA. TUFTS UNIV,DEPT CHEM ENGN,MEDFORD,MA 02155. UNIV IOWA,DEPT CHEM & BIOCHEM ENGN,IOWA CITY,IA 52242. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 179 EP BIOT PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18500772 ER PT J AU Bentley, MD Chung, BY AF Bentley, MD Chung, BY TI PEG-linked artemisinin antimalarials. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MAINE,DEPT CHEM,ORONO,ME 04469. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 217 EP POLY PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP187 UT WOS:A1997WP18702954 ER PT J AU Munavalli, S Rohrbaugh, DK Wagner, GW Berg, FJ Rossman, DI Durst, HD AF Munavalli, S Rohrbaugh, DK Wagner, GW Berg, FJ Rossman, DI Durst, HD TI Trifluoromethylthiolation of enamines SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCTR INC,FT WASHINGTON,MD 20774. USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 242 EP MEDI PN 2 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA WP187 UT WOS:A1997WP18701266 ER PT J AU Song, PJ AF Song, PJ TI Performance evaluation of a prototype field ion spectrometer. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10997. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 279 EP CHED PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18501425 ER PT J AU Chung, JC AF Chung, JC TI Quantitative evaluation of the use of zeolites as a detoxification catalyst SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,W POINT,NY 10997. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 284 EP CHED PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18501430 ER PT J AU Zhang, JW Gross, RA Allen, AL Kaplan, DL AF Zhang, JW Gross, RA Allen, AL Kaplan, DL TI Biosynthetic strategies to tailor the structure of bioemulsifiers from Acinetobacter calcoaceticus RAG-1 SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV LOWELL,DEPT CHEM,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. TUFTS UNIV,DEPT CHEM ENGN,MEDFORD,MA 02155. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 288 EP PMSE PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP187 UT WOS:A1997WP18703604 ER PT J AU Jalkanen, KJ DeKock, R Bunte, SW McNesby, KL Goodin, DB Jensen, GM AF Jalkanen, KJ DeKock, R Bunte, SW McNesby, KL Goodin, DB Jensen, GM TI Density functional calculations of the Raman spectra of 3-methylindole and Ti2Cl6 SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 CALVIN COLL, GRAND RAPIDS, MI 49546 USA. USA, RES LAB, AMSRL, WM, PC, ABERDEEN PROVING GROUND, MD 21005 USA. Scripps Res Inst, DEPT MOL BIOL, LA JOLLA, CA 92037 USA. RI Jalkanen, Karl/A-2456-2008 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 305 EP PHYS PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP187 UT WOS:A1997WP18702561 ER PT J AU Bunte, SW Jensen, GM Warshel, A Goodin, DB AF Bunte, SW Jensen, GM Warshel, A Goodin, DB TI Combined ab initio and electrostatic calculations of tryptophan-191 oxidation in compound ES of cytochrome c peroxidase SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA, RES LAB, AMSRL, WT, PC, ABERDEEN PROVING GROUND, MD 21005 USA. Scripps Res Inst, DEPT MOL BIOL, LA JOLLA, CA 92037 USA. UNIV SO CALIF, DEPT CHEM, LOS ANGELES, CA 90089 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 306 EP PHYS PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP187 UT WOS:A1997WP18702562 ER PT J AU Alvarez, LM Shea, C Fountain, AW Riegner, D Salin, M AF Alvarez, LM Shea, C Fountain, AW Riegner, D Salin, M TI Mechanism of oxidative bleaching of chlorophyllin SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 312 EP CHED PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18501458 ER PT J AU Ayyagari, MS Akkara, JA AF Ayyagari, MS Akkara, JA TI Enzymatic synthesis of multifunctional polyphenols for biosensor applications. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,SOLDIER SYST COMMAND,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 369 EP PMSE PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP187 UT WOS:A1997WP18703685 ER PT J AU Stewart, FF Peterson, ES Stone, ML Singler, RE AF Stewart, FF Peterson, ES Stone, ML Singler, RE TI Synthesis and characterization of polyphosphazene copolymers using phosphorus-31 NMR spectroscopy SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 LOCKHEED MARTIN IDAHO TECHNOL,IDAHO NATL ENGN LAB,IDAHO FALLS,ID 83414. US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 436 EP POLY PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP187 UT WOS:A1997WP18703173 ER PT J AU Chabalowski, CF Jensen, JO Stephens, PJ Devlin, FJ Frisch, MJ Cheeseman, JR AF Chabalowski, CF Jensen, JO Stephens, PJ Devlin, FJ Frisch, MJ Cheeseman, JR TI Ab initio calculations of vibrational circular dichroism and infrared spectra using SCF, MP2 and density functional theories for a series of molecules. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21005. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 465 EP PHYS PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP187 UT WOS:A1997WP18702720 ER PT J AU Munavalli, S Rohrbaugh, DK Wagner, GW Berg, FJ Rossman, DI Durst, HD AF Munavalli, S Rohrbaugh, DK Wagner, GW Berg, FJ Rossman, DI Durst, HD TI Trifluoromethylthiolation of trimethylsilyl enol ethers. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,FT WASHINGTON,MD 20774. USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 531 EP ORGN PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP187 UT WOS:A1997WP18701976 ER PT J AU Springer, DS AF Springer, DS TI A new direction in general chemistry. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 13 PY 1997 VL 213 BP 725 EP CHED PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA WP185 UT WOS:A1997WP18501871 ER PT J AU Zuber, M Hoover, TA Dertzbaugh, MT Court, DL AF Zuber, M Hoover, TA Dertzbaugh, MT Court, DL TI A Francisella tularensis DNA clone complements Escherichia coli defective for the production of Era, an essential Ras-like GTP-binding protein SO GENE LA English DT Article DE aspC; cloning; mdh; sequencing; Tularemia ID STREPTOCOCCUS-MUTANS; RNC OPERON; EXPRESSION; GENE; LVS AB We cloned the era gene of Francisella tularensis from a plasmid library by heterologous genetic complementation of an Escherichia coli mutant conditionally defective for the production of Era, an essential protein for cell growth. Nucleotide sequence analysis indicated that, in F. tularensis, era constitutes a single gene operon. ORFs aspC and mdh encoding aspartate aminotransferase and malate dehydrogenase, respectively, Bank era in F. tularensis. Although classified as Gram(-), the flanking regions and the relative location of era in F. tularensis are distinctly different from those of typical Gram(-) and Gram(+) bacteria. Computer analysis of bacterial Era protein sequences identified conserved domains in addition to the common G domains of most GTP-binding proteins. (C) 1997 Elsevier Science B.V. C1 USA,MED RES INST INFECT DIS,BACTERIOL DIV,FT DETRICK,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV TOXICOL,FT DETRICK,FREDERICK,MD 21702. RP Zuber, M (reprint author), NCI,MOL CONTROL & GENET SECT,GENE REGULAT & CHROMOSOME BIOL LAB,ABL BASIC RES PROGRAM,FREDERICK,MD 21702, USA. NR 17 TC 23 Z9 29 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1119 J9 GENE JI Gene PD APR 11 PY 1997 VL 189 IS 1 BP 31 EP 34 DI 10.1016/S0378-1119(96)00813-X PG 4 WC Genetics & Heredity SC Genetics & Heredity GA WX270 UT WOS:A1997WX27000006 PM 9161408 ER PT J AU Britton, P Lu, XCM Laskosky, MS Tortella, FC AF Britton, P Lu, XCM Laskosky, MS Tortella, FC TI Dextromethorphan protects against cerebral injury following transient, but not permanent, focal ischemia in rats SO LIFE SCIENCES LA English DT Article DE focal cerebral ischemia; middle cerebral artery occlusion; dextromethorphan; neuroprotection ID METHYL-D-ASPARTATE; GUINEA-PIG BRAIN; ARTERY OCCLUSION; BINDING-SITES; GLUTAMATE NEUROTOXICITY; MILD HYPOTHERMIA; INFARCT VOLUME; SIGMA-LIGANDS; DEXTRORPHAN; NEURONS AB Dextromethorphan (DM) has been observed to afford neuroprotection in a variety of in vitro and in vivo experimental models of CNS injury. We have evaluated the neuroprotective activity of DM following both transient (2 h) and permanent focal cerebral ischemia in the rat. Middle cerebral artery occlusion (MCAO) was produced in male Sprague-Dawley rats using the intraluminal filament technique. Animals were dosed s.c with 20 mg/kg DM at 0.5, 1, 2, 4, and 6 hours post occlusion. Analysis of brain injury was performed 24 hours after permanent occlusion or reperfusion. Following transient MCAO, vehicle treated rats exhibited a total infarct volume of 203 +/- 33 mm(3). DM produced a 61% reduction in infarct volume to 79 +/- 13 mm(3). Permanent MCAO produced a larger infarct volume (406 +/- 44 mm(3)) which was not significantly reduced in size by treatment with DM (313 +/- 58 mm(3)). Infarcted hemispheric oedema was not different in vehicle treated rats following transient or permanent MCAO and was not reduced by DM in either group. Following transient MCAO, rectal temperature was elevated 1, 2 and 5 hours post occlusion. While not inducing hypothermia or altering physiological parameters such as blood pressure and blood gases, DM attenuated this injury-related increase in temperature, an effect which appeared to correlate with its ability to protect neurons in temperature regulating hypothalamic centres. The DM-induced reduction in infarction demonstrated in our model of transient focal cerebral ischemia provides further support for the in vivo neuroprotective activity of this compound. Importantly, these data demonstrate the limited neuroprotective efficacy of DM when attempting to combat more severe focal ischemic injuries and imply that drug-induced hypothermia is not ultimately responsible for its protective action. RP Britton, P (reprint author), WALTER REED ARMY INST RES,DIV NEUROSCI,DEPT NEUROPHARMACOL & MOL BIOL,WASHINGTON,DC 20307, USA. NR 52 TC 48 Z9 48 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PD APR 11 PY 1997 VL 60 IS 20 BP 1729 EP 1740 DI 10.1016/S0024-3205(97)00132-X PG 12 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA WT909 UT WOS:A1997WT90900001 PM 9150412 ER PT J AU Mathews, S Ramesh, R Venkatesan, T Benedetto, J AF Mathews, S Ramesh, R Venkatesan, T Benedetto, J TI Ferroelectric field effect transistor based on epitaxial perovskite heterostructures SO SCIENCE LA English DT Article AB Ferroelectric field effect devices offer the possibility of nonvolatile active memory elements. Doped rare-earth manganates, which are usually associated with colossal magnetoresistive properties, have been used as the semiconductor channel material of a prototypical epitaxial field effect device. The carrier concentration of the semiconductor channel can be ''tuned'' by varying the manganate stochiometry, A device with La0.7Ca0.3MnO3 as the semiconductor and PbZr0.2Ti0.8O3 as the ferroelectric gate exhibited a modulation in channel conductance of at least a factor of 3 and a retention loss of 3 percent after 45 minutes without power. C1 UNIV MARYLAND,CTR SUPERCONDUCT RES,COLLEGE PK,MD 20742. USA,RES LAB,ADELPHI,MD 20783. RP Mathews, S (reprint author), UNIV MARYLAND,DEPT MAT & NUCL ENGN,COLLEGE PK,MD 20742, USA. RI Venkatesan, Thirumalai/E-1667-2013 NR 11 TC 398 Z9 404 U1 17 U2 111 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD APR 11 PY 1997 VL 276 IS 5310 BP 238 EP 240 DI 10.1126/science.276.5310.238 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA WT925 UT WOS:A1997WT92500039 ER PT J AU Carroll, RG Riley, JL Levine, BL Feng, Y Kaushal, S Ritchey, DW Bernstein, W Weislow, OS Brown, CR Berger, EA June, CH StLouis, DC AF Carroll, RG Riley, JL Levine, BL Feng, Y Kaushal, S Ritchey, DW Bernstein, W Weislow, OS Brown, CR Berger, EA June, CH StLouis, DC TI Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4(+) T cells SO SCIENCE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; MOLECULAR-CLONING; MONOCLONAL-ANTIBODIES; CROSS-LINKING; HUMAN HOMOLOG; NPY BINDING; ACTIVATION; RECEPTOR; GENE; RESPONSES AB Activation of CD4(+) T lymphocytes from human immunodeficiency virus-type 1 (HIV-1)-infected donors with immobilized antibodies to CD3 and CD28 induces a virus-resistant state. This effect is specific for macrophage-tropic HIV-I, Transcripts encoding CXCR4/Fusin, the fusion cofactor used by T cell line-tropic isolates, were abundant in CD3/CD28-stimulated cells, but transcripts encoding CCR5, the fusion cofactor used by macrophage-tropic viruses, were not detectable. Thus, CD3/CD28 costimulation induces an HIV-1-resistant phenotype similar to that seen in some highly exposed and HIV-uninfected individuals. C1 HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD 20850. USN,MED RES INST,IMMUNE CELL BIOL PROGRAM,BETHESDA,MD 20889. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. NIAID,VIRAL DIS LAB,NIH,BETHESDA,MD 20889. SRA TECHNOL,ROCKVILLE,MD 20850. NIAID,INFECT DIS LAB,NIH,ROCKVILLE,MD 20852. RI Levine, Bruce/D-1688-2009 NR 51 TC 160 Z9 161 U1 0 U2 1 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD APR 11 PY 1997 VL 276 IS 5310 BP 273 EP 276 DI 10.1126/science.276.5310.273 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA WT925 UT WOS:A1997WT92500051 PM 9092480 ER PT J AU Mukerjee, R Chaturvedi, UC Vaughn, DW Kalayanarooj, S AF Mukerjee, R Chaturvedi, UC Vaughn, DW Kalayanarooj, S TI Purification and pathogenicity of the cytotoxic factor from the cases of dengue haemorrhagic fever SO CURRENT SCIENCE LA English DT Article ID CYTO-TOXIC FACTOR; BLOOD LEUKOCYTES; VIRUS-INFECTION; MICE; PATHOGENESIS; MACROPHAGES; SPLEEN AB Pathogenesis of dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS) is not yet clear in spite of extensive efforts. Here we report the discovery of a cytotoxic cytokine (hCF) in the sera of the patients with DHF/DSS which is capable of increasing vascular permeability in mice. The presence of hCF was detected in the sera of the cases of DHF by dot blot test. hCF was purified from the sera of 34 dot blot-positive patients of DHF by ion-exchange chromatography followed by high performance liquid chromatography. The eluted hCF was cytotoxic to normal mouse spleen cells, had a molecular weight of 43 kD and an isoelectric point of pH 4.5-5. It reacted in dot blot and Western blot tests with anti-mouse cytotoxic factor (mCF) and anti-hCF-antisera. The effect of hCF on the capillary permeability and the blood-brain barrier of mice was investigated using leakage of Evans blue dye-bound plasma proteins. It was observed that inoculation of the hCF in mice increased the capillary permeability and damaged the blood-brain barrier in a dose-dependent manner. This is the first evidence of the presence of cytotoxic factor (hCF), a homologue of mCF, in the sera of the cases of DHF/DSS which can cause reversible damage to capillaries. C1 ARMED FORCES RES INST MED SCI,DEPT VIROL,BANGKOK 10400,THAILAND. CHILDRENS HOSP,BANGKOK 10400,THAILAND. RP Mukerjee, R (reprint author), KG MED COLL,POSTGRAD DEPT MICROBIOL,LUCKNOW 226003,UTTAR PRADESH,INDIA. NR 23 TC 16 Z9 16 U1 0 U2 0 PU CURRENT SCIENCE ASSN PI BANGALORE PA C V RAMAN AVENUE, PO BOX 8005, BANGALORE 560 080, INDIA SN 0011-3891 J9 CURR SCI INDIA JI Curr. Sci. PD APR 10 PY 1997 VL 72 IS 7 BP 494 EP 501 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA WU894 UT WOS:A1997WU89400023 ER PT J AU Wu, JZ Yun, SH Gapud, A Kang, BW Kang, WN Tidrow, SC Monahan, TP Cui, XT Chu, WK AF Wu, JZ Yun, SH Gapud, A Kang, BW Kang, WN Tidrow, SC Monahan, TP Cui, XT Chu, WK TI Epitaxial growth of HgBa2CaCu2O6+delta thin films on SrTiO3 substrates SO PHYSICA C LA English DT Article AB High quality c-axis oriented HgBa2CaCu2O6+delta thin films have been grown epitaxially on SrTiO3 substrates with the a-axis of the film aligned with the (100)-axis of the substrates. The film-substrate interface quality can be greatly improved by using a fast temperature ramping Hg-vapor annealing process (FTRA). Zero-resistance T-c values above 120 K are routinely obtained for FTRA processed HgBa2CaCu2O6+delta thin films. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. UNIV HOUSTON,TEXAS CTR SUPERCOND,HOUSTON,TX 77204. RP Wu, JZ (reprint author), UNIV KANSAS,DEPT PHYS & ASTRON,LAWRENCE,KS 66045, USA. RI Tidrow, Steven/C-8133-2013; OI Gapud, Albert/0000-0001-9048-9230 NR 5 TC 36 Z9 36 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-4534 J9 PHYSICA C JI Physica C PD APR 10 PY 1997 VL 277 IS 3-4 BP 219 EP 224 DI 10.1016/S0921-4534(97)00077-4 PG 6 WC Physics, Applied SC Physics GA WY066 UT WOS:A1997WY06600008 ER PT J AU Weidenbacher, HJ Barnes, MJ AF Weidenbacher, HJ Barnes, MJ TI Target search in tactical displays with standard, single cue, and redundant coding SO DISPLAYS LA English DT Article DE visual search; tactical displays; military symbology; redundant coding ID PERCEPTION; ATTENTION; INFORMATION; FEATURES AB We examined the cognitive dimensions of search performance of 12 military subjects looking for targets embedded within standard military symbols, redundantly coded symbols, and symbols constituting the inner boundaries of the standard symbols and the outer boundaries of the redundant symbols. As predicted, the results indicated that visual search was more efficient for redundantly coded symbols than for symbols encoded using the standard conventions. However, observers performed fastest when viewing the inner configuration of the standard symbol in isolation, These findings confirm that visual search performance for standard military symbols is not optimal, and are interpreted in light of current models of perceptual grouping and attention. (C) 1997 Elsevier Science B.V. C1 ARMY RES LAB,SIERRA VISTA,AZ 85616. RP Weidenbacher, HJ (reprint author), UNIV HERTFORDSHIRE,PSYCHOL DIV,HATFIELD AL10 9AB,HERTS,ENGLAND. NR 19 TC 1 Z9 1 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0141-9382 J9 DISPLAYS JI Displays PD APR 9 PY 1997 VL 18 IS 1 BP 1 EP 10 DI 10.1016/S0141-9382(96)01027-X PG 10 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic; Instruments & Instrumentation; Optics SC Computer Science; Engineering; Instruments & Instrumentation; Optics GA XJ803 UT WOS:A1997XJ80300001 ER PT J AU Young, CF Xie, K Poindexter, EH Gerardi, GJ Keeble, DJ AF Young, CF Xie, K Poindexter, EH Gerardi, GJ Keeble, DJ TI Electron paramagnetic resonance of nitrogen pairs and triads in 6H-SiC: Analysis and identification SO APPLIED PHYSICS LETTERS LA English DT Article ID CARBIDE AB A study of electron paramagnetic resonance (EPR) of nitrogen-doped 6H-SiC is reported here. By use of both first- and second-harmonic EPR detection, the predicted spectral fingerprints for nitrogen pairs and triads were found at low temperatures. The pair spectrum was present in the second harmonic, while the spectral feature for both nitrogen pairs and triads was evidenced in the first harmonic. At least one nitrogen donor of the identified pairs and triads is located at one of the two available quasicubic carbon sites, and the other(s) could be at any one of the two quasicubic sites and the hexagonal carbon site. (C) 1997 American Institute of Physics. C1 WILLIAM PATERSON COLL NEW JERSEY,DEPT CHEM & PHYS,WAYNE,NJ 07758. UNIV DUNDEE,CARNEGIE LAB PHYS,DUNDEE DD1 4DH,SCOTLAND. RP Young, CF (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. RI Keeble, David /C-6633-2012 OI Keeble, David /0000-0002-5378-799X NR 11 TC 10 Z9 10 U1 1 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 7 PY 1997 VL 70 IS 14 BP 1858 EP 1860 DI 10.1063/1.118713 PG 3 WC Physics, Applied SC Physics GA WT147 UT WOS:A1997WT14700027 ER PT J AU VanderHamm, DG AF VanderHamm, DG TI Human subject research SO SCIENCE LA English DT Letter RP VanderHamm, DG (reprint author), USA,MED RES & MAT COMMAND,MCMR RCQ HR,504 SCOTT ST,FT DETRICK,MD 21702, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD APR 4 PY 1997 VL 276 IS 5309 BP 17 EP 17 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA WR386 UT WOS:A1997WR38600002 PM 9122694 ER PT J AU Rada, R Schoening, J AF Rada, R Schoening, J TI IEEE efforts towards standards in educational technology SO ACM SIGPLAN NOTICES LA English DT Article C1 USA,COMMUN ELECT COMMAND,FT MONMOUTH,NJ 07703. RP Rada, R (reprint author), WASHINGTON STATE UNIV,PULLMAN,WA 99164, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 1515 BROADWAY, NEW YORK, NY 10036 SN 0362-1340 J9 ACM SIGPLAN NOTICES JI ACM Sigplan Not. PD APR PY 1997 VL 32 IS 4 BP 16 EP 18 DI 10.1145/254459.254462 PG 3 WC Computer Science, Software Engineering SC Computer Science GA WZ793 UT WOS:A1997WZ79300001 ER PT J AU Stevens, JB Hecker, RB Talbot, JC Walker, SC AF Stevens, JB Hecker, RB Talbot, JC Walker, SC TI The haemodynamic effects of rocuronium and vecuronium are different under balanced anaesthesia SO ACTA ANAESTHESIOLOGICA SCANDINAVICA LA English DT Article DE neuromuscular relaxants, pancuronium, rocuronium, vecuronium ID HISTAMINE-RELEASE; ORG-9426; PANCURONIUM; TUBOCURARINE; ANESTHESIA; ATRACURIUM; AGENT AB Background: Rocuronium has been reported to have minimal haemodynamic effects. However, this conclusion has been drawn primarily from investigations conducted under narcotic-based anaesthesia. This study was designed to evaluate the cardiovascular effects of rocsuronium under isoflurane/N2O/fentanyl anaesthesia and to compare rocuronium's haemodynamic effects to those of vecuronium and pancuronium. Methods: Anaesthesia was induced with fentanyl 2 mu g/kg, thiopentone 4 mg/kg, and suxamethonium 0.5 mg/kg in 75 ASA I or II patients. After tracheal intubation, anaesthesia was maintained with isoflurane 0.5% and N2O 50% in oxygen. Five min after intubation (baseline), patients randomly received either vecuronium 100 mu g/kg, rocuronium 600 mu g/kg, rocuronium 900 mu g/kg, rocuronium 1200 mu g/kg, or pancuronium 140 mu g/kg. One min after administration of muscle relaxant, mean arterial pressure (MAP) and heart rate (HR) were recorded and were subsequently measured at 1-min intervals for the next 4 min. Results: HR decreased significantly (P<0.05) at all times compared to baseline in patients receiving vecuronium. HR significantly (P<0.05) increased in those receiving rocuronium 1200 mu g/kg or pancuronium. Patients who received vecuronium had a significant (P<0.05) decrease in MAP at all times compared to baseline. Comparing results between groups, patients who received rocuronium or pancuronium had significantly (P<0.05) higher MAP compared to those administered vecuronium. Conclusion: The haemodynamic effect of rocuronium and vecuronium are different under balanced anaesthesia. Rocuronium may attenuate the fall in MAP that often occurs under balanced anaesthesia without surgical stimulation. (C) Acta Anaesthesiologica Scandinavica 41 (1997). RP Stevens, JB (reprint author), BROOKE ARMY MED CTR,DEPT ANESTHESIA,ANESTHESIOL SERV,SAN ANTONIO,TX 78284, USA. NR 16 TC 10 Z9 10 U1 0 U2 3 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0001-5172 J9 ACTA ANAESTH SCAND JI Acta Anaesthesiol. Scand. PD APR PY 1997 VL 41 IS 4 BP 502 EP 505 PG 4 WC Anesthesiology SC Anesthesiology GA XB251 UT WOS:A1997XB25100011 PM 9150779 ER PT J AU Mather, B AF Mather, B TI Discussion of ''the process of sulfate attack on cement mortars'' SO ADVANCED CEMENT BASED MATERIALS LA English DT Editorial Material RP Mather, B (reprint author), USA,ENGINEER WATERWAYS EXPT STN,STRUCT LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 3 TC 4 Z9 6 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1065-7355 J9 ADV CEM BASED MATER JI Adv. Cem. Based Mater. PD APR-MAY PY 1997 VL 5 IS 3-4 BP 109 EP 110 DI 10.1016/S1065-7355(96)00007-7 PG 2 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA WY630 UT WOS:A1997WY63000006 ER PT J AU Holland, TD OBrien, MJ AF Holland, TD OBrien, MJ TI Parasites, porotic hyperostosis, and the implications of changing perspectives SO AMERICAN ANTIQUITY LA English DT Article ID IRON-DEFICIENCY; CRIBRA ORBITALIA; ADAPTATION; ETIOLOGY; DISEASE; HYPOFERREMIA; ANEMIA AB Cribra orbitalia and porotic hyperostosis traditionally have been viewed (at least by archaeologists) as indicators of chronic iron deficiency anemia resulting from a dependency upon maize. Recent interpretations, however have sought to explain these conditions as an evolutionary, adaptive response to intestinal parasites rather than as a consequence of poor nutrition. Thus diet is eliminated as a contributing factor. This model, however, adopts too simplistic a view of evolution. Furthermore, it concomitantly severs the well-documented link that exists between cranial lesions and cereal-based subsistence. A more realistic approach would be to incorporate both diet and pathogens (bacterial as well as parasitic) into a symbiotic model that acknowledges the important role of parasites in the etiology of cribra orbitalia and porotic hyperostosis, while maintaining the diagnostic value of these conditions as hallmarks of early agriculture. C1 UNIV MISSOURI,DEPT ANTHROPOL,COLUMBIA,MO 65211. RP Holland, TD (reprint author), USA,CENT IDENTIFICAT LAB,HICKAM AFB,HI 96853, USA. NR 67 TC 29 Z9 31 U1 0 U2 13 PU SOC AMER ARCHAEOLOGY PI WASHINGTON PA 900 SECOND ST., NE WASHINGTON, DC 20002-3557 SN 0002-7316 J9 AM ANTIQUITY JI Am. Antiq. PD APR PY 1997 VL 62 IS 2 BP 183 EP 193 DI 10.2307/282505 PG 11 WC Anthropology; Archaeology SC Anthropology; Archaeology GA WW265 UT WOS:A1997WW26500003 ER PT J AU Taylor, AJ Byers, JP Cheitlin, MD Virmani, R AF Taylor, AJ Byers, JP Cheitlin, MD Virmani, R TI Anomalous right or left coronary artery from the contralateral coronary sinus: ''High-risk'' abnormalities in the initial coronary artery course and heterogeneous clinical outcomes SO AMERICAN HEART JOURNAL LA English DT Article ID RIGHT AORTIC SINUS; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; PULMONARY TRUNK; SUDDEN-DEATH; ORIGIN; VALSALVA; ANGIOGRAPHY; IDENTIFICATION; DIAGNOSIS AB Coronary artery anomalies are associated with sudden cardiac death, although individual patient outcomes are highly variable. We performed blinded pathologic analysis of 30 consecutive cases of anomalous right (n = 21) or left (n = 9) coronary artery from the contralateral coronary sinus to determine which, if any, features might aid in risk stratification for sudden cardiac death. We found no significant differences in length of aortic intramural segment, coronary ostial size, degree of displacement of the anomalous coronary artery from the correct coronary sinus, or angle of coronary takeoff between patients with (n = 12) and without (n = 18) sudden cardiac death. All pathologic features showed considerable interpatient variability. Age greater than or equal to 30 years was the only variable associated with a decreased incidence of sudden cardiac death. Thus no simple relation exists between variations in the initial coronary artery course and clinical outcome in these anomalies. C1 ARMED FORCES INST PATHOL,DIV CARDIOVASC,WASHINGTON,DC 20307. SAN FRANCISCO GEN HOSP,DIV CARDIOL,SAN FRANCISCO,CA 94110. WALTER REED ARMY MED CTR,DEPT MED,SERV CARDIOL,WASHINGTON,DC 20307. NR 29 TC 175 Z9 182 U1 1 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD APR PY 1997 VL 133 IS 4 BP 428 EP 435 DI 10.1016/S0002-8703(97)70184-4 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA WQ960 UT WOS:A1997WQ96000007 PM 9124164 ER PT J AU Marshall, JR Lanza, E Bloch, A Caan, B Caggiula, A Quandt, S Iber, F Kikendall, W Slattery, M Sowell, A AF Marshall, JR Lanza, E Bloch, A Caan, B Caggiula, A Quandt, S Iber, F Kikendall, W Slattery, M Sowell, A TI Indexes of food and nutrient intakes as predictors of serum concentrations of nutrients: The problem of inadequate discriminant validity SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article; Proceedings Paper CT Proceedings of a Symposium / 2nd International Conference on Dietary Assessment Methods CY JAN 22-24, 1995 CL BOSTON, MA DE alpha-carotene; beta-carotene; vitamin E; alpha-tocopherol; validity; food-frequency questionnaire; discriminant validity; convergent validity ID FREQUENCY QUESTIONNAIRE; BETA-CAROTENE; ALPHA-TOCOPHEROL; CANCER; MEN; DATABASE; DIET; FAT AB Nutrient indexes derived from food-frequency questionnaires have generally been regarded as acceptably valid for epidemiologic purposes. Evaluations of these indexes, however, have considered only their convergent validity. We suggest that discriminant validity, or the ability to distinguish among exposures to different nutrients, is also important. Using baseline data from a large clinical trial, we tested the discriminant validity of indexes of intake of vitamin E, alpha-carotene, and beta-carotene. Our results suggest that the vitamin E index possesses neither convergent nor discriminant validity, the alpha-carotene index adequate convergent and discriminant validity, and the beta-carotene index adequate convergent but no discriminant validity. C1 SUNY BUFFALO, SCH MED & BIOMED SCI, DEPT SOCIAL & PREVENT MED, BUFFALO, NY 14260 USA. NCI, BETHESDA, MD 20892 USA. MEM SLOAN KETTERING CANC CTR, NEW YORK, NY 10021 USA. KAISER FDN RES INST, OAKLAND, CA USA. UNIV PITTSBURGH, PITTSBURGH, PA 15260 USA. WAKE FOREST UNIV, WINSTON SALEM, NC 27109 USA. EDWARD HINES JR VET ADM HOSP, HINES, IL 60141 USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. UNIV UTAH, SALT LAKE CITY, UT USA. CTR DIS CONTROL & PREVENT, ATLANTA, GA USA. RP Marshall, JR (reprint author), UNIV ARIZONA, ARIZONA CANC CTR, 1515 N CAMPBELL AVE, POB 245024, TUCSON, AZ 85724 USA. NR 31 TC 13 Z9 13 U1 14 U2 14 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD APR PY 1997 VL 65 IS 4 SU S BP 1269 EP 1274 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA WR606 UT WOS:A1997WR60600031 ER PT J AU Lanza, E Schatzkin, A Caan, B Weissfeld, J Cooper, R Marshall, J Shike, M Burt, R Slattery, M Iber, F Kikendall, W Mateski, D Cahill, J Brewer, B AF Lanza, E Schatzkin, A Caan, B Weissfeld, J Cooper, R Marshall, J Shike, M Burt, R Slattery, M Iber, F Kikendall, W Mateski, D Cahill, J Brewer, B TI Dietary assessment data from the Polyp Prevention Trial SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Meeting Abstract DE Polyp Prevention Trial; food-frequency questionnaire; 4-d diet record; energy intake; dietary fiber; fruit; vegetable C1 NCI, NIH, BETHESDA, MD 20892 USA. KAISER FDN, RES INST, OAKLAND, CA USA. WAKE FOREST UNIV, BOWMAN GRAY SCH MED, WINSTON SALEM, NC USA. SUNY BUFFALO, BUFFALO, NY 14260 USA. UNIV UTAH, SALT LAKE CITY, UT USA. EDWARD HINES VET ADM MED CTR, HINES, IL 60141 USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. WESTAT CORP, ROCKVILLE, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD APR PY 1997 VL 65 IS 4 SU S BP 1340 EP 1340 PG 1 WC Nutrition & Dietetics SC Nutrition & Dietetics GA WR606 UT WOS:A1997WR60600169 ER PT J AU Colina, RE Smith, M Kikendall, JW Wong, RKH AF Colina, RE Smith, M Kikendall, JW Wong, RKH TI A new probable increasing cause of esophageal ulceration: Alendronate SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID POSTMENOPAUSAL WOMEN; BIOCHEMICAL MARKERS; ORAL ALENDRONATE; BONE MASS; OSTEOPOROSIS; DENSITY AB We present a case of esophageal ulcerations caused by alendronate (Fosamax), a recently marketed medication. The patient presented with a chief complaint of retrosternal pain and severe odynophagia of 5 days duration. She was taking prednisone 10 mg and azathioprine 100 mg p.o. q.d for systemic lupus erythematosus. To prevent osteoporosis, she was started on alendronate 10 mg q.d. 2 wk before her symptoms started, Endoscopy of the upper GI tract revealed two deep, large ulcers at the gastroesophageal junction. Multiple biopsy specimens revealed necroinflammatory debris and acute esophagitis. However, no organisms mere identified, and the result of her HIV test (ELISA) was negative. Alendronate was discontinued, and her symptoms resolved completely in 1 wk. Follow-up endoscopy performed 4 wk later revealed complete healing of the ulcers. RP Colina, RE (reprint author), WALTER REED ARMY MED CTR,DEPT GASTROENTEROL,6825 GEORGIA AVE NW,WASHINGTON,DC 20307, USA. NR 11 TC 47 Z9 48 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD APR PY 1997 VL 92 IS 4 BP 704 EP 706 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WV786 UT WOS:A1997WV78600034 PM 9128331 ER PT J AU Williams, RF Moran, EL Bottaro, SD Dydek, GJ Caouette, ML Thomas, JD Echevarria, R AF Williams, RF Moran, EL Bottaro, SD Dydek, GJ Caouette, ML Thomas, JD Echevarria, R TI Pharmaceutical services in the United States Army SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Article DE administration; ambulatory care; education, pharmaceutical; health-benefit programs; managed care systems; manpower; military; personnel, pharmacy; pharmaceutical services; pharmacists; pharmacoeconomics; pharmacy, institutional, hospital; United States Army ID PHARMACOECONOMIC CENTER; SUPPORT AB The status of pharmaceutical services in the United States Army is described. The Army Medical Department (AMEDD) has 157 commissioned pharmacy officers and 399 civilian pharmacists working in the United States and overseas. Pharmaceutical services are provided from fixed medical treatment facilities on Army installations and, during war and other field operations, field hospitals. Reductions in personnel and facility closures have helped align the AMEDD with the size of the Army's active-duty force, but there has been only a 15% reduction in the number of eligible beneficiaries. Measures such as the interservice TRICARE program have been implemented to help meet the continued high demand for pharmaceutical services cost-effectively. Army pharmacy is similar to civilian pharmacy, except that Army hospitals often include high-volume outpatient pharmacies not usually found in civilian institutions. Pharmacists are being given direct patient care roles on multidisciplinary teams. Army pharmacists participate in field exercises so that they will be prepared to provide services under combat conditions. The AMEDD trains its own pharmacy technicians in a highly structured 18-week course. A triservice Pharmacoeconomic Center (PEG) has been established with the goal of providing prescribers with the tools for making cost-effective decisions about drug therapy, including a formulary. Army pharmacy officers have broad opportunities to further their education and training. In preparing for the next century, Army pharmacists need to continue to prove their value to the AMEDD, the Army, and the Department of Defense. C1 DEPT DEF,PHARMACOECON CTR,FT SAM HOUSTON,TX. REYNOLDS ARMY COMMUNITY HOSP,SERV PHARM,FT SILL,OK. TRIPLER ARMY MED CTR,DEPT PHARM,HONOLULU,HI 96859. BROOKE ARMY MED CTR,PHARM PRACTICE,FT SAM HOUSTON,TX 78234. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ARMY MED DEPT CTR & SCH,FT SAM HOUSTON,TX 78234. RP Williams, RF (reprint author), USA,MED COMMAND,MCHO-CL-R,2050 WORTH RD,SUITE 10,FT SAM HOUSTON,TX 78234, USA. NR 6 TC 3 Z9 3 U1 0 U2 1 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD APR 1 PY 1997 VL 54 IS 7 BP 773 EP 778 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA WR644 UT WOS:A1997WR64400011 PM 9099343 ER PT J AU Watters, MR Cannard, KR Burton, BS Turner, GE AF Watters, MR Cannard, KR Burton, BS Turner, GE TI MR findings in essential hypertension - Reply SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Letter C1 UNIV HAWAII,SCH MED,TRIPLER ARMY MED CTR,SERV NEURORADIOL,HONOLULU,HI 96822. RP Watters, MR (reprint author), UNIV HAWAII,SCH MED,TRIPLER ARMY MED CTR,NEUROL SERV,HONOLULU,HI 96822, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD APR PY 1997 VL 18 IS 4 BP 789 EP 789 PG 1 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA WU592 UT WOS:A1997WU59200060 ER PT J AU BuiMansfield, LT Youngberg, RA Warme, W Pitcher, JD Nguyen, PLL AF BuiMansfield, LT Youngberg, RA Warme, W Pitcher, JD Nguyen, PLL TI Potential cost savings of MR imaging obtained before arthroscopy of the knee: Evaluation of 50 consecutive patients SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID ANTERIOR CRUCIATE LIGAMENT; MENISCAL TEARS; DIAGNOSIS; PATTERNS; SIGNAL; IMAGES AB OBJECTIVE. We attempted to determine the potential cost savings of prearthroscopic knee MR imaging examinations. SUBJECTS AND METHODS. This prospective study involved 50 consecutive patients. The patients met the surgical-indications-for-monitoring-appropriateness criteria for knee arthroscopy and underwent MR imaging of the knee before arthroscopy. For all patients, we compared MR imaging and arthroscopic findings. On the basis of a cost of $1000 for each MR imaging examination and $4000 for each diagnostic arthroscopy, we decided that cost-effective MR imaging would require 25% true negativity. RESULTS. The respective sensitivities and specificities of MR imaging of the knee were 100% and 90% ibr revealing anterior cruciate ligament interruption, 100% and 84% for revealing posterior cruciate ligament tears, 90% and 97% for revealing medial meniscal tears, 60% and 100% for revealing lateral meniscal tears, and 94% and 93% for revealing composite injury (one or more of these abnormalities). With MR imaging examinations obtained before surgery, we found 21 (42%) of 50 arthroscopies to be unnecessary. CONCLUSION. Despite stringent clinical criteria used in select:ng patients for arthroscopy, 42% of our patients could have been spared surgery on the basis of the anatomy revealed by MR imaging. Our study indicates that MR imaging obtained before arthroscopy of the knee can produce a savings of as much as $680 per MR imaging examination performed on the knee. C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. MADIGAN ARMY MED CTR,DEPT SURG,ORTHOPED SURG SERV,TACOMA,WA 98431. RP BuiMansfield, LT (reprint author), MADIGAN ARMY MED CTR,DEPT RADIOL,TACOMA,WA 98431, USA. NR 17 TC 38 Z9 41 U1 1 U2 3 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD APR PY 1997 VL 168 IS 4 BP 913 EP 918 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA WQ211 UT WOS:A1997WQ21100008 PM 9124139 ER PT J AU Shorr, AF Yacavone, M Seguin, S Jackson, LW Dennis, GJ AF Shorr, AF Yacavone, M Seguin, S Jackson, LW Dennis, GJ TI Dermatomyositis and malignant melanoma SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES LA English DT Article DE dermatomyositis; malignancy; melanoma ID POLYMYOSITIS; CANCER AB Patients with dermatomyositis may face an increased risk of malignancy. Malignant melanoma has been linked to dermatomyositis. We present a case of concomitant dermatomyositis and metastatic malignant melanoma and review the English literature concerning this topic. Analysis revealed that the development of dermatomyositis in patients with malignant melanoma heralds the diagnosis of metastatic disease. These patients face dismal prognoses. C1 WALTER REED ARMY MED CTR,DIV RHEUMATOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV DERMATOL,WASHINGTON,DC 20307. RP Shorr, AF (reprint author), WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307, USA. NR 11 TC 12 Z9 12 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-9629 J9 AM J MED SCI JI Am. J. Med. Sci. PD APR PY 1997 VL 313 IS 4 BP 249 EP 251 DI 10.1097/00000441-199704000-00011 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA WR445 UT WOS:A1997WR44500011 PM 9099158 ER PT J AU Petras, JM Kyle, DE Gettayacamin, M Young, GD Bauman, RA Webster, HK Corcoran, KD Peggins, JO Vane, MA Brewer, TG AF Petras, JM Kyle, DE Gettayacamin, M Young, GD Bauman, RA Webster, HK Corcoran, KD Peggins, JO Vane, MA Brewer, TG TI Arteether: Risks of two-week administration in Macaca mulatta SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ANTIMALARIAL DRUG; ARTEMISININ; ARTEMETHER; NEUROTOXICITY; QINGHAOSU; CHILDREN; MALARIA AB Male rhesus monkeys (Macaca mulatta) were administered daily doses of the antimalarial drug arteether. The 14-day treated group received either 24 mg/kg/day, 16 mg/kg/day, or 8 mg/kg/day. The seven-day treatment group received either 24 mg/kg/day or 8 mg/kg/day. All control cases in each group received the sesame oil vehicle alone. Neurologic signs were absent for animals in the seven and 14-day treatment groups except for one monkey which showed diffuse piloerection on day 14, and another monkey receiving 24 mg/kg/day for seven days showed mild lethargy after the fourth day. Mild, sporadic anorexia was noted in all animals by day 14, and a single animal showed diffuse piloerection on day 14. Surgical anesthesia preceded killing by exsanguination and was accompanied by perfusion fixation of the central nervous syste. Brain sections were cut and then stained for study by light microscopy. Evidence of neuronal pathology, both descriptive and numerical, was collected. The neuroanatomic and neuropathologic findings demonstrated that arteether produced extensive brainstem injury when administered for 14 days. The magnitude of brainstem neurotoxicity was dose-dependent, where injury was greatest ar the 24 mg/kg/day dose level, less at the 10 mg/kg/day dose level, and feast at the 8 mg/kg/day dose level. Arteether induced multiple systems injury to brainstem nuclei of 1) the reticular formation (cranial and caudal pontine nuclei, and medullary gigantocellular and paragigantocellular nuclei); 2) the vestibular system (medial, descending, superior, and lateral nuclei); and 3) the auditory system (superior olivary nuclear complex and trapezoid nuclear complex). The vestibular nuclei and. the reticular formation were most severely injured, with the auditory system affected less. The cranial nerve nuclei (somatic and splanchnic) appeared to escape damage, with the exception, of the abducens nerve nucleus. The same brainstem nuclear groups of seven-day treated monkeys appeared normal. The statistical data an concordant with the descriptive data in demonstrating: neurotoxic effects. In summary, no neurologic deficits were detected in any of the vehicle control monkeys (14-day and seven-day cases). Monkeys in the 14-day treatment group were free of clinical neurologic signs throughout the first week. At day 14, fine horizontal nystagmus was seen in one monkey, and another monkey exhibited diffuse piloerection. Monkeys in the seven-day treatment group were free of clinical neurologic signs except for one case. This monkey was treated with 24/mg/kg/day of arteether and exhibited lethargy after the fourth day. These indications of dysfunction arose too late to be practical indicators of neurotoxicity. C1 USA,CTR HLTH PROMOT & PREVENT MED,ABERDEEN PROVING GROUND,MD 21010. BECTON DICKINSON CO,ASIA PACIFIC REG,SINGAPORE 2263,SINGAPORE. FITZSIMONS ARMY MED CTR,DEPT CLIN INVEST,AURORA,CO 80045. WALTER REED ARMY INST RES,DEPT PHARMACOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DIV EXPT THERAPEUT,WASHINGTON,DC 20307. ARMED FORCES RES INST MED SCI,US MED COMPONENT,APO,AP 96546. RP Petras, JM (reprint author), WALTER REED ARMY INST RES,DEPT NEUROBEHAV ASSESSMENT,DIV NEUROSCI,WASHINGTON,DC 20307, USA. NR 28 TC 58 Z9 64 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1997 VL 56 IS 4 BP 390 EP 396 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA WY260 UT WOS:A1997WY26000007 PM 9158046 ER PT J AU Sudiro, TM Ishiko, H Green, S Vaughn, DW Nisalak, A Kalayanarooj, S Rothman, AL Raengsakulrach, B Janus, J Kurane, I Ennis, FA AF Sudiro, TM Ishiko, H Green, S Vaughn, DW Nisalak, A Kalayanarooj, S Rothman, AL Raengsakulrach, B Janus, J Kurane, I Ennis, FA TI Rapid diagnosis of Dengue viremia by reverse transcriptase-polymerase chain reaction using 3'-noncoding region universal primers SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID COMPLETE NUCLEOTIDE-SEQUENCE; LINKED IMMUNOSORBENT-ASSAY; VIRUS GENOME RNA; NONSTRUCTURAL PROTEINS; IDENTIFICATION; AMPLIFICATION; FLAVIVIRUSES; INFECTIONS; MOSQUITOS; SEROTYPES AB A reverse transcriptase-polymerase chain reaction (RT-PCR) method was developed as a rapid diagnostic test of dengue viremia. To detect dengue viruses in serum or plasma specimens, a pair of universal primers was designed for use in the RT-PCR. Using these primers, the 3'-noncoding region of dengue virus types 1, 2, 3, and 4 could be amplified, but not those of other flaviviruses, such as West Nile virus, Japanese encephalitis virus, and yellow fever virus, or the alphavirus Sindbis virus. The sensitivity of the RT-PCR assay was similar to that of a quantitative fluorescent focus assay of dengue viruses in cell culture. Combining a silica method for RNA isolation at RT-PCR dengue virus could be detected in a 6-hr assay. In a preliminary study using this method, we detected dengue virus in 38 of 39 plasma specimens from which dengue virus had been isolated by mosquito inoculation. We then applied this method for detecting dengue viremia to 117 plasma samples from 62 children with acute febrile illnesses in a dengue-endemic area. We detected dengue viremia in 19 of 20 samples obtained on the day of presentation, which had been confirmed as acute dengue infection by mosquito inoculation and antibody responses. The overall sensitivity of this method was 91.4% (32 of 35; 95% confidence interval [CI] = 82.2-100%). The results from testing plasma samples from febrile nondengue patients showed a specificity of 95.4% (42 of 44; 95% CI = 89.3-100%). C1 ARMED FORCES RES INST MED SCI,DEPT VIROL,USA MED COMPONENT,BANGKOK,THAILAND. BANGKOK CHILDRENS HOSP,DEPT INFECT DIS,BANGKOK,THAILAND. RP Sudiro, TM (reprint author), UNIV MASSACHUSETTS,MED CTR,DIV INFECT DIS & IMMUNOL,55 LAKE AVE N,WORCESTER,MA 01655, USA. FU NIAID NIH HHS [P01-AI-34533] NR 27 TC 49 Z9 53 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1997 VL 56 IS 4 BP 424 EP 429 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA WY260 UT WOS:A1997WY26000013 PM 9158052 ER PT J AU Garcia, G Vaughn, DW DelAngel, RM AF Garcia, G Vaughn, DW DelAngel, RM TI Recognition of synthetic oligopeptides from nonstructural proteins NS1 and NS3 of dengue-4 virus by sera from dengue virus-infected children SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID RECOMBINANT VACCINIA VIRUS; MONOCLONAL-ANTIBODIES; GLYCOPROTEIN NS1; MICE; PATHOGENESIS; IMMUNIZATION; ENCEPHALITIS; PROTECTION; SITES AB The nonstructural proteins NS1 and NS3 from dengue virus are involved in the immune response during natural infection in humans. To analyze the immunogeneity of some epitopes present in NS1 and NS3 proteins from dengue virus type-4, six oligopeptides were synthesized; five from NS1 (NS1.1, NS1.2, NS1.3, NS1.4, and NS1.5) and one from NS3 (NS3.1). Peptides NS1.1, NS1.2, NS1.3, NS1.5, and NS3.1 were recognized by sera from dengue virus-infected children, suggesting that they represent exposed epitopes during natural dengue virus infection. C1 ARMED FORCES RES INST MED SCI,DEPT VIROL,BANGKOK 10400,THAILAND. RP Garcia, G (reprint author), INST POLITECN NACL,CTR INVEST & ESTUDIOS AVANZADOS,DEPT PATOL EXPT,MEXICO CITY,DF,MEXICO. RI del Angel, Rosa/E-3711-2013; OI del Angel, Rosa/0000-0002-3241-9565; del Angel, Rosa/0000-0002-6785-2035 NR 23 TC 26 Z9 28 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1997 VL 56 IS 4 BP 466 EP 470 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA WY260 UT WOS:A1997WY26000020 PM 9158059 ER PT J AU Anderson, GW Worsham, PL Bolt, CR Andrews, GP Welkos, SL Friedlander, AM Burans, JP AF Anderson, GW Worsham, PL Bolt, CR Andrews, GP Welkos, SL Friedlander, AM Burans, JP TI Protection of mice from fatal bubonic and pneumonic plague by passive immunization with monoclonal antibodies against the F1 protein of Yersinia pestis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID RECOMBINANT AB Monoclonal antibodies (MAbs) to the fraction 1 (F1) protein of Yersinia pestis protected mice against fatal pneumonic as well as bubonic plague from wild-type F1+ organisms. The rare isolation of a virulent F1- isolate from surviving animals supports earlier studies suggesting that improved vaccines should consist of immunogens to protect against F1- variants. The high degree of protection with IgG MAb suggests that secretory IgA is not required for protection from pneumonic plague. C1 USN,MED RES INST,BETHESDA,MD 20889. RP Anderson, GW (reprint author), USA,MED RES INST INFECT DIS,BACTERIOL DIV,FT DETRICK,FREDERICK,MD 21702, USA. NR 25 TC 63 Z9 64 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1997 VL 56 IS 4 BP 471 EP 473 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA WY260 UT WOS:A1997WY26000021 PM 9158060 ER PT J AU Kosisky, SE Carpenter, GB AF Kosisky, SE Carpenter, GB TI Predominant tree aeroallergens of the Washington, DC area: A six year survey (1989-1994) SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Article ID METROPOLITAN AREA; AIRBORNE FUNGI; POLLEN COUNTS; POLLINOSIS; ALLERGY; AEROBIOLOGY; CALIFORNIA; COLORADO; DENVER AB Objective: A 6-year (1989 to 1994) aerobiologic survey of the Washington DC area was performed to identify predominant area tree pollens, atmospheric concentrations, and peak flowering periods. Methods: Aeroallergen sampling was conducted using a volumetric rotating-arm impaction Rotorod sampler (Sampling Technologies, Inc, Los Altos Hills, California). Results: The Washington DC pollen calendar may begin as early as January when pollen of the Cupresseacea, Aceracea, Pinaceae, and Betulaceae are observed in small amounts. February through June encompasses the major part of our tree season with considerable overlapping of pollination periods for various trees. The Ulmaceae have two distinct pollinating times with later flowering species of elm pollinating August through October coinciding with ragweed season. April is usually the month with the highest weekly average concentrations. Each year oaks contribute more than 50% of the total tree pollen count followed by pollen of the Pinacea, Cupresseacea, Moracea, and Betuleacea. Times for onset of pollination as well as peak atmospheric concentrations varied from year to year. High production years for some tree aeroallergens are low years for others. Conclusion: The Washington DC area is exposed to significant atmospheric concentrations of tree pollen from February through June. Establishing what area tree aeroallergens predominate with respect to their atmospheric concentrations and peak pollinating times is essential for the effective diagnosis and treatment of the tree-allergic patient. RP Kosisky, SE (reprint author), WALTER REED ARMY MED CTR,ALLERGEN EXTRACT LAB,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20307, USA. NR 50 TC 19 Z9 20 U1 0 U2 2 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD APR PY 1997 VL 78 IS 4 BP 381 EP 392 PG 12 WC Allergy; Immunology SC Allergy; Immunology GA WU261 UT WOS:A1997WU26100009 PM 9109706 ER PT J AU Topf, AI AF Topf, AI TI Preoperative clinical evaluation of the cardiac patient for noncardiac surgery SO ANNALS OF INTERNAL MEDICINE LA English DT Letter RP Topf, AI (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD APR 1 PY 1997 VL 126 IS 7 BP 584 EP 584 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA WQ195 UT WOS:A1997WQ19500023 PM 9092326 ER PT J AU Karle, JM AF Karle, JM TI X-ray crystal structure of the antimalarial agent (-)-halofantrine hydrochloride supports stereospecificity for cardiotoxicity SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID METABOLITE N-DESBUTYLHALOFANTRINE; RESISTANT FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; HALOFANTRINE; ENANTIOMERS; MEFLOQUINE; EFFICACY; THAILAND; INVITRO; PLASMA AB The crystal and molecular structures and absolute configuration of (-)-halofantrine hydrochloride were determined by X-ray diffraction, The absolute configuration of the single chiral center of (-)-halofantrine was established to be in the S configuration, Thus, (+)-halofantrine, the more cardiotoxic isomer, has the R configuration, The carbon atom adjacent to the aromatic ring has the same configuration in both (+)halofantrine and quinidine, suggesting a stereospecific component to the cardiotoxicity produced by both agents, The intramolecular N ... O distance is 4.177 +/- 0.006 Angstrom (1 Angstrom = 0.1 nm), which is close to the N ... O distance found in the crystal structure of (+/-)-halofantrine hydrochloride, even though the N-H group points in opposite directions in racemic halofantrine and (-)-halofantrine, Both the hydroxyl group and the amine group form hydrogen bonds With the chloride anions, The crystallographic parameters for (-)-halofantrine hydrochloride were as follows: chemical formula, C26H31Cl2F6NO+. Cl-; M(r) 492.4; symmetry of unit cell orthorhombic; space group(delta) P2(l)2(l)2(l); parameters of unit cell, a was 6.290 +/- 0.001 Angstrom, b was 13.533 +/- 0.003 Angstrom, and c was 30.936 +/- 0.006 Angstrom; volume of the unit cell, 2,633.2 +/- 0.7 Angstrom(3); number of molecules per unit cell, 4; calculated density, 1.354 g cm(-3); source of radiation, Cu K alpha (lambda = 1.54178 Angstrom); mu (adsorption coefficient), 3.50 (-1); F(000) (sum of atomic scattering factors at zero scattering angle), 1,120; room temperature was used; final R (residual index), 4.75% for 2,988 reflections, with \F-0\ > 3 sigma(F), where F-0 is the observed structure factor and F is the structure factor. RP Karle, JM (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPT THERAPEUT,WASHINGTON,DC 20307, USA. NR 23 TC 8 Z9 9 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD APR PY 1997 VL 41 IS 4 BP 791 EP 794 PG 4 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA WR166 UT WOS:A1997WR16600015 PM 9087491 ER PT J AU Callahan, HL Portal, AC Devereaux, R Grogl, M AF Callahan, HL Portal, AC Devereaux, R Grogl, M TI An axenic amastigote system for drug screening SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID LEISHMANIA-MEXICANA AMASTIGOTES; SODIUM STIBOGLUCONATE; VISCERAL LEISHMANIASIS; ANTIMONIAL DRUGS; ANTILEISHMANIAL DRUGS; MEGLUMINE ANTIMONIATE; ENZYME-ACTIVITIES; INVITRO ACTIVITY; CELL-LINES; ACIDIC PH AB Currently available primary screens for selection of candidate antileishmanial compounds are not ideal. The choices include screens that are designed to closely reflect the situation in vivo but are labor-intensive and expensive (intracellular amastigotes and animal models) and screens that are designed to facilitate rapid testing of a large number of drugs but do not use the clinically relevant parasite stage (promastigote model). The advent of successful in vitro culture of axenic amastigotes permits the development of a primary screen which is quick and easy like the promastigote screen but still representative of the situation in vivo, since it uses the relevant parasite stage. We have established an axenic amastigote drug screening system using a Leishmania mexicana strain (strain M379). A comparison of the 50% inhibitory concentration (IC50) drug sensitivity profiles of M379 promastigotes, intracellular amastigotes, and axenic amastigotes for six clinically relevant antileishmanial drugs (sodium stibogluconate, meglumine antimoniate, pentamidine, paromomycin, amphotericin B, WR6026) showed that M379 axenic amastigotes are a good model for a primary drug screen. Promastigote and intracellular amastigote IC(50)s differed for four of the six drugs tested by threefold or more; axenic amastigote and intracellular amastigote IC(50)s differed by twofold for only one drug. This shows that the axenic amastigote susceptibility to clinically used reference drugs is comparable to the susceptibility of amastigotes in macrophages. These data also suggest that for the compounds tested, susceptibility is intrinsic to the parasite stage. This contradicts previous hypotheses that suggested that the activities of antimonial agents against intracellular amastigotes were solely a function of the macrophage. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPT THERAPEUT,WASHINGTON,DC 20307. RP Callahan, HL (reprint author), USAMRU BRAZIL,AMER CONSULATE RIO,APO,AA 34030, USA. NR 74 TC 91 Z9 95 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD APR PY 1997 VL 41 IS 4 BP 818 EP 822 PG 5 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA WR166 UT WOS:A1997WR16600020 PM 9087496 ER PT J AU Adler, ET Cable, BB Casler, JD Greenspan, RB AF Adler, ET Cable, BB Casler, JD Greenspan, RB TI Pathologic quiz case 2 - Pathologic diagnosis: External nasal schwannoma SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID MASSES; MANAGEMENT RP Adler, ET (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 12 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD APR PY 1997 VL 123 IS 4 BP 443 EP 445 PG 3 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA WT849 UT WOS:A1997WT84900017 PM 9109797 ER PT J AU Braithwaite, MG AF Braithwaite, MG TI The British Army Air Corps in-flight spatial disorientation demonstration sortie SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article AB Following didactic instruction, most aircrew are able to experience some of the disorientating illusions and limitations of the orientational senses in a variety of ground-based devices. In order to reinforce instruction in spatial disorientation (SD) within the environment in which they operate, British Army Air Corps helicopter pilots also receive an airborne demonstration of the limitations of their orientation senses. Since 1982, a specific SD sortie has been programmed towards the end of the basic rotary-wing phase of flight training approximately 6 weeks after the aeromedical training module, and before students commence rotary wing instrument flight training. Refresher sorties are flown every 4 years. The conduct of the SD sortie is described in detail. Analysis of helicopter accidents demonstrates that this training is operationally effective by contributing towards the reduction of SD-related mishaps. It is cost-effective and the addition of this type of in-flight demonstration to the aeromedical training syllabus is regarded as being of great value to British Army helicopter aircrew. Similar instruction could be readily adopted by other services. RP Braithwaite, MG (reprint author), USA,AEROMED RES LAB,FT RUCKER,AL 36362, USA. NR 6 TC 5 Z9 5 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD APR PY 1997 VL 68 IS 4 BP 342 EP 345 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA WR011 UT WOS:A1997WR01100011 PM 9096833 ER PT J AU Patterson, DE Braverman, SE Belandres, PV AF Patterson, DE Braverman, SE Belandres, PV TI Speech dysfunction due to trazodone-fluoxetine combination in traumatic brain injury SO BRAIN INJURY LA English DT Article; Proceedings Paper CT 1995 Association-of-Academic-Psychiatrists Meeting CY MAR, 1995 CL SCOTTSDALE, AZ SP Assoc Acad Physiatrists ID DRUG-DRUG INTERACTIONS; MOTOR RECOVERY; ANTIDEPRESSANTS; DEPRESSION; PATIENT AB New serotonin reuptake inhibitors are available for the treatment of affective disorders and sleep dysfunction in traumatic brain injury (TBI) patients. Commonly reported serotonergic side-effects include nausea, headache, dizziness, nervousness, and orthostatic hypotension. Trazodone, a nonselective serotonin reuptake inhibitor, is often used in conjunction with fluoxetine, a selective serotonin reuptake inhibitor, in order to combat the insomnia associated with fluoxetine. Successful use of this combination is generally limited by the cumulative serotonergic side-effects of the two medications. This paper describes the first reported case of speech dysfunction as a complication of combined trazodone and fluoxetine use. A 43-year-old male suffered bilateral wrist fractures and a moderate TBI during a fall. Within 1 week of adding fluoxetine to trazodone the patient developed new-onset dysarthria and speech blocking. Upon discontinuation of fluoxetine, speech returned to normal. Possible mechanisms include inhibition of hepatic metabolism, unmasking of caudate nucleus injury, increased noradrenergic activity or previously unreported serotonergic effects. This case illustrates the importance of monitoring drug combinations for unexpected side-effects in the TBI population. C1 WALTER REED ARMY MED CTR,DEPT PHYS MED & REHABIL,RES TRAINING PROGRAM,WASHINGTON,DC 20307. NR 19 TC 10 Z9 10 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0269-9052 J9 BRAIN INJURY JI Brain Inj. PD APR PY 1997 VL 11 IS 4 BP 287 EP 291 PG 5 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA WQ736 UT WOS:A1997WQ73600006 PM 9134203 ER PT J AU Meoni, P Tortella, FC Bowery, NG AF Meoni, P Tortella, FC Bowery, NG TI An autoradiographic study of dextromethorphan high-affinity binding sites in rat brain: Sodium-dependency and colocalization with paroxetine SO BRITISH JOURNAL OF PHARMACOLOGY LA English DT Article DE dextromethorphan; paroxetine; antitussives; autoradiography; 5-HT uptake; sigma receptors ID GUINEA-PIG BRAIN; ANTITUSSIVE DRUGS; SIGMA-LIGANDS; METABOLISM; PROTECTS; ROPIZINE; AGENTS AB 1 The distribution and some pharmacological properties of centrally located dextromethorphan high-affinity binding sites were investigated by in vitro autoradiography. 2 Sodium chloride (50 mM) induced a 7 to 12 fold increase in dextromethorphan binding to rat brain in all areas tested. The effect of sodium was concentration-dependent with a higher dose (120 mM) exerting a smaller effect on binding. 3 [H-3]-dextromethorphan binding in the presence of sodium was inhibited in the presence of the anticonvulsant phenytoin at a concentration of 100 mu M, while the sigma ligand (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)pipendine ((+)-PPP) had no effect on the binding, suggesting an interaction with the DM(2) site. 4 The distribution of the sodium-dependent binding identified in this study correlated significantly with the distribution of the selective 5-HT uptake inhibitor [H-3]-paroxetine, and paroxetine and dextromethorphan mutually displaced their binding at concentrations in the low nanomolar range. 5 These data show that dextromethorphan and paroxetine share a sodium-dependent high affinity binding site in rat brain, and suggest that dextromethorphan might interact, in the presence of sodium, with the 5-HT uptake mechanism in rat brain. C1 UNIV LONDON,SCH PHARM,DEPT PHARMACOL,LONDON WC1N 1AX,ENGLAND. WALTER REED ARMY INST RES,NEUROPHARMACOL BRANCH,WASHINGTON,DC. RP Meoni, P (reprint author), UNIV BIRMINGHAM,SCH MED,DEPT PHARMACOL,VINCENT DR,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND. NR 32 TC 20 Z9 20 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0007-1188 J9 BRIT J PHARMACOL JI Br. J. Pharmacol. PD APR PY 1997 VL 120 IS 7 BP 1255 EP 1262 DI 10.1038/sj.bjp.0701043 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA WR269 UT WOS:A1997WR26900010 PM 9105700 ER PT J AU Meadows, GA Meadows, LA Wood, WL Hubertz, JM Perlin, M AF Meadows, GA Meadows, LA Wood, WL Hubertz, JM Perlin, M TI The relationship between great lakes water levels, wave energies, and shoreline damage SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article ID EQUILIBRIUM RANGE; NORTH-AMERICA; SPECTRUM; CYCLONES AB The latter half of the twentieth century can be characterized as a period of rising water levels on the Great Lakes, with record high levels in 1974 and 1986. Concurrent with these periods of high water level are reported periods of high shoreline damage and property loss. Water levels of the Great Lakes are determined by precipitation, evaporation, river outflow, and groundwater inflow, while wave energy is primarily a function of wind speed, duration, and fetch. A comparison between a recently completed long-term (1956-87) wave climate hindcast and historical lake levels for the Great Lakes shows a strong correlation between periods of high wave energy and high lake levels. Statistical comparison of these two time series indicates an approximately constant correlation from +24 months to -6 months, around a zero lag/lead. The causational link between increasing lake levels and more intense wind-generated waves appears to be related to significant changes in the climatology of Great Lake's basin cyclones. Support for this conclusion is provided by an apparent interdecadal climate change reflected by a marked shift in track lines of extratropical cyclones passing over the Great Lakes and by a parallel decrease in lake levels and wave energies in the time period from 1976 to 1978. Finally and perhaps most importantly, it is shown that periods of reported high shoreline damage and property loss correlate more directly to periods of high wave energy than to periods of peak water level. C1 PURDUE UNIV,SCH CIVIL ENGN,W LAFAYETTE,IN 47907. USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180. RP Meadows, GA (reprint author), UNIV MICHIGAN,DEPT NAVAL ARCHITECTURE & MARINE ENGN,N CAMPUS 2145,ANN ARBOR,MI 48109, USA. NR 36 TC 17 Z9 17 U1 1 U2 7 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0003-0007 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD APR PY 1997 VL 78 IS 4 BP 675 EP 683 DI 10.1175/1520-0477(1997)078<0675:TRBGLW>2.0.CO;2 PG 9 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA XA634 UT WOS:A1997XA63400004 ER PT J AU Gorkovenko, A Zhang, JW Gross, RA Allen, AL Kaplan, DL AF Gorkovenko, A Zhang, JW Gross, RA Allen, AL Kaplan, DL TI Bioengineering of emulsifier structure: Emulsan analogs SO CANADIAN JOURNAL OF MICROBIOLOGY LA English DT Article DE emulsan; Acinetobacter calcoaceticus RAG-1; fatty acids; direct incorporation; emulsification activity ID ARTHROBACTER RAG-1; OIL AB Strategies were investigated to modulate the side chain structure of emulsans formed by Acinetobacter calcoaceticus RAG-1. Analysis of emulsan fatty acid side chain groups by gas chromatography - mass spectrometry (GC-MS) revealed that by providing the exogenous n-alkanoic fatty acids 15:0, 16:0, and 17:0, emulsan analogs were formed with 53, 46, and 44 mol%, respectively, of fatty acid substituents with chain lengths equal to that of the carbon source. In contrast, the increase in emulsan fatty acids of chain lengths less than 15 or greater than 17 by providing corresponding shorter and longer chain length fatty acids as carbon sources was not substantial. When [1-C-13]-labeled (99% enriched) palmitic acid was used as a carbon source along with acetate, analysis of m/z 75/74 and 87/88 isotopomer ratios by GC-MS indicated that 84 and 86% of the 16:0 and 16:1 (9-cis) side groups, respectively, were incorporated intact from the 16:0 carbon source. The percentage of 14-, 15-, 16-, 17-, and 18-carbon chain length fatty acid esters that were monounsaturated were 11, 26, 50, 70, and 85%, respectively. Based on the observed percentage of unsaturated chain length dependence and almost identical enrichment at C-1 of 16:0 and 16:1 (9-cis) side groups from [1-C-13]-labeled experiments, it was concluded that desaturation of preformed n-alkanoic acids was the predominant mechanism of their formation. Further work established correlations between side chain structure and product emulsification specificity/activity, so that bioengineered emulsans with improved selectivity can now be formed. C1 UNIV LOWELL,DEPT CHEM,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. RI Zhang, Jinwen/G-8674-2014 OI Zhang, Jinwen/0000-0001-8828-114X NR 17 TC 23 Z9 26 U1 0 U2 0 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4166 J9 CAN J MICROBIOL JI Can. J. Microbiol. PD APR PY 1997 VL 43 IS 4 BP 384 EP 390 PG 7 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology; Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology; Microbiology GA XB727 UT WOS:A1997XB72700011 PM 9115094 ER PT J AU Cardello, AV AF Cardello, AV TI Food stereotypes: Prejudice in the pantry SO CEREAL FOODS WORLD LA English DT Article ID DISGUST RP Cardello, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 9 TC 2 Z9 2 U1 1 U2 2 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD APR PY 1997 VL 42 IS 4 BP 231 EP 233 PG 3 WC Food Science & Technology SC Food Science & Technology GA WU752 UT WOS:A1997WU75200006 ER PT J AU Eliasson, AH Howard, RS Torrington, KG Dillard, TA Philips, YY AF Eliasson, AH Howard, RS Torrington, KG Dillard, TA Philips, YY TI Do-not-resuscitate decisions in the medical ICU - Comparing physician and nurse opinions SO CHEST LA English DT Article DE do-not-resuscitate orders; ethics; nurse opinions; physician opinions ID INTENSIVE-CARE; ADVANCE DIRECTIVES; LIFE-SUPPORT; ORDERS; WITHDRAWAL; SYSTEM; UNITS AB Study objective: To determine how soon after admission to a medical ICU physicians and nurses decide that attempts at resuscitation are inappropriate and how frequently physicians and nurses disagree about do-not-resuscitate (DNR) decisions. Design: Prospective, opinion survey of care providers. Setting: Ten-bed adult medical ICU in a university-affiliated tertiary care referral hospital. Patients: Consecutive adult medical ICU admissions. Interventions: Over 10 months, physicians and nurses were surveyed independently every day regarding their opinions about DNR issues on each patient in the ICU. Measurements: ICU day when DNR order was deemed appropriate by either physicians or nurses. Results: Of 368 consecutive admissions, 84 (23%) patients were designated DNR during their ICU stay. In 6 of these 84 cases (7%), the responsible nurse did not agree that DNR orders were appropriate. In the remaining 78 patients designated DNR, the median time for physicians to recommend DNR (median, 1 day; range, 0 to 22 days) was not significantly different from the median time for nurses (median, 1 day; range, 0 to 13 days); (p=0.45). For the 284 patients not designated DNR, physicians and nurses both believed DNR was appropriate in 14 cases (5%), but a DNR order was not written five times (2%) because there was not time to do so and nine times (3%) because patient or family did not concur. Physicians and nurses disagreed about a DNR recommendation in 33 of the 284 patients not designated DNR (12%), Physicians were more likely to believe that DNR was appropriate than were nurses (p<0.0005), with physicians alone recommending DNR 29 times (10%) and nurses alone favoring DNR in four cases (1%). Conclusions: At our institution, recognition of DNR appropriateness by nurses and physicians occurs over a similar time frame. However, physicians are more likely to recommend DNR in cases of disagreement between nurses and physicians. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. NR 22 TC 27 Z9 27 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD APR PY 1997 VL 111 IS 4 BP 1106 EP 1111 DI 10.1378/chest.111.4.1106 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA WT736 UT WOS:A1997WT73600043 PM 9106594 ER PT J AU Moores, LK Burrell, LM Morse, RW Belgrave, CH Balingit, AG AF Moores, LK Burrell, LM Morse, RW Belgrave, CH Balingit, AG TI Diffuse tumor microembolism - A rare cause of a high-probability perfusion scan SO CHEST LA English DT Article DE cor pulmonale; perfusion; thromboembolism; tumor embolism ID SUBACUTE COR-PULMONALE; EMBOLIZATION AB Pulmonary turner embolism is a rare but well-documented cause of respiratory failure in patients with-cancer. This entity is probably clinically underrecognized and may represent an important cause of morbidity and mortality. A typical pattern of multiple peripheral subsegmental defects on perfusion lung scanning has been described. We present a case of a unilateral near absence of perfusion in a 53-year-old woman who on autopsy was found to have diffuse tumor microembolism. As new chemotherapeutic agents are developed for the treatment of malignancies, an early diagnosis may become more important. A high-probability perfusion scan should not dissuade the clinician from pursuing further evaluation. Cytologic findings of pulmonary venous blood may be diagnostic. C1 WALTER REED ARMY MED CTR,DEPT NUCL MED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. RP Moores, LK (reprint author), WALTER REED ARMY MED CTR,DEPT MED,7100 GEORGIA AVE NW,WASHINGTON,DC 20307, USA. NR 8 TC 9 Z9 9 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD APR PY 1997 VL 111 IS 4 BP 1122 EP 1125 DI 10.1378/chest.111.4.1122 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA WT736 UT WOS:A1997WT73600049 PM 9106600 ER PT J AU Berman, JD AF Berman, JD TI Human leishmaniasis: Clinical, diagnostic, and chemotherapeutic developments in the last 10 years SO CLINICAL INFECTIOUS DISEASES LA English DT Review ID AMERICAN CUTANEOUS LEISHMANIASIS; HUMAN-IMMUNODEFICIENCY-VIRUS; LIPOSOMAL AMPHOTERICIN-B; POLYMERASE CHAIN-REACTION; DIRECT AGGLUTINATION-TEST; SODIUM STIBOGLUCONATE PENTOSTAM; AZAR DERMAL LEISHMANIASIS; INDIAN KALA-AZAR; OPERATION-DESERT-STORM; PLUS INTERFERON-GAMMA AB The current interest in leishmaniasis stems from the importance of this disease with respect to travel medicine, veterans of Operation Desert Storm, humanitarian concerns, and infection with human immunodeficiency virus. Herein, I review aspects of leishmaniasis that are of practical value to practitioners, including presentation, diagnosis, and chemotherapy; I will emphasize advances in chemotherapy over the last 10 years. Amphotericin B and its new lipid formulations are now competitive with pentavalent antimony as primary therapy for visceral leishmaniasis. Pentamidine, paromomycin, and adjunctive therapy with interferon-gamma are secondary regimens for the treatment of this condition. High-dose long-term regimens of antimony have been shown to be highly effective for the treatment of cutaneous leishmaniasis. Preliminary evidence of efficacy has been observed with short courses of pentamidine for the treatment of Leishmania braziliensis complex disease and topical paromomycin/methylbenzethonium chloride for the treatment of Leishmania major disease. RP Berman, JD (reprint author), WALTER REED ARMY INST RES,DIV EXPT THERAPEUT,WASHINGTON,DC 20307, USA. NR 169 TC 519 Z9 551 U1 5 U2 20 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR PY 1997 VL 24 IS 4 BP 684 EP 703 DI 10.1093/clind/24.4.684 PG 20 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA WT725 UT WOS:A1997WT72500021 PM 9145744 ER PT J AU Moore, MA Britt, TW Leary, MR AF Moore, MA Britt, TW Leary, MR TI Integrating social and counseling psychological perspectives on the self SO COUNSELING PSYCHOLOGIST LA English DT Article ID DEPRESSIVE SYMPTOMS; RACIAL IDENTITY; BLACK-STUDENTS; MENTAL-HEALTH; MODEL; ACTUALIZATION; INFORMATION; DISCREPANCY; PERSONALITY; ATTITUDES AB Few areas present a more ideal opportunity for dialogue between counseling and social psychologists than the self. Both disciplines have contributed significantly to the development of self theories and the design of methodologies suitable for understanding processes and practices relevant to the self. However, counseling and social psychologists are finding it increasingly necessary to value and actively initiate interdisciplinary discussion and collaboration in order to prevent cognitive blind spots in understandings of the self In this article, the authors examine impediments to successful bridging of the disciplines and highlight areas ripe for interface within the arenas of professional training and development, theory, practice, methodology, metatheory, and epistemology. More specifically, the authors identify cultural, interpersonal, developmental motivational, evaluative, regulatory, structural, and vocational aspects of the self that would benefit from collaborative inquiry Throughout this article, the authors attempt to balance illustrations of the actual and potential applications of knowledge relevant to the self with calls to counseling and social psychologists to work together to ensure the relevance of their self analyses to diverse cultures. C1 UNIV MARYLAND,EUROPEAN DIV,COLLEGE PK,MD 20742. WALTER REED ARMY INST RES,GERMANY UNIT,WASHINGTON,DC. WAKE FOREST UNIV,WINSTON SALEM,NC 27109. NR 88 TC 5 Z9 5 U1 1 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 0011-0000 J9 COUNS PSYCHOL JI Couns. Psychol. PD APR PY 1997 VL 25 IS 2 BP 220 EP 239 DI 10.1177/0011000097252004 PG 20 WC Psychology, Applied SC Psychology GA WP462 UT WOS:A1997WP46200004 ER PT J AU Borecky, DJ Stephenson, JJ Keeling, JH Vukelja, SJ AF Borecky, DJ Stephenson, JJ Keeling, JH Vukelja, SJ TI Idarubicin-induced pigmentary changes of the nails SO CUTIS LA English DT Article ID THERAPY AB A case of acute myelocytic leukemia of the FAB-M2 subtype in a patient who experienced pigmentary nail changes in conjunction with idarubicin therapy is presented. Although doxorubicin and daunorubicin have been reported to cause nail pigmentation changes, this is the first case report to describe these changes with idarubicin. C1 BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234. NR 9 TC 4 Z9 4 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD APR PY 1997 VL 59 IS 4 BP 203 EP 204 PG 2 WC Dermatology SC Dermatology GA WT942 UT WOS:A1997WT94200011 PM 9104543 ER PT J AU Simonson, DC Kourides, IA Feinglos, M Shamoon, H Fischette, CT Aronoff, S Blonde, L Cefalu, W Clement, S Greenberg, C Levin, S Lucas, CP Macy, C Manning, J Marbury, TC McAdams, MJ Mezitis, NHE Miller, S Owens, D Sandler, J Schwartz, SL Shamoon, H Sosenko, J AF Simonson, DC Kourides, IA Feinglos, M Shamoon, H Fischette, CT Aronoff, S Blonde, L Cefalu, W Clement, S Greenberg, C Levin, S Lucas, CP Macy, C Manning, J Marbury, TC McAdams, MJ Mezitis, NHE Miller, S Owens, D Sandler, J Schwartz, SL Shamoon, H Sosenko, J TI Efficacy, safety, and dose-response characteristics of glipizide gastrointestinal therapeutic system on glycemic control and insulin secretion in NIDDM - Results of two multicenter, randomized, placebo-controlled clinical trials SO DIABETES CARE LA English DT Article; Proceedings Paper CT American-Diabetes-Association Annual Meeting and Scientific Sessions CY JUN 11-14, 1994 CL NEW ORLEANS, LA SP Amer Diabet Assoc ID DEPENDENT DIABETES-MELLITUS; ORAL HYPOGLYCEMIC AGENTS; HEPATIC GLUCOSE-PRODUCTION; SULFONYLUREA THERAPY; GLYBURIDE THERAPY; TYPE-2 DIABETICS; PHARMACOKINETICS; PATHOGENESIS; PHARMACOLOGY; METABOLISM AB OBJECTIVE - To investigate the efficacy, safety, and dose-response characteristics of an extended-release preparation of glipizide using the gastrointestinal therapeutic system (GITS) on plasma glucose, glycosylated hemoglobin (HbA(1c)), and insulin secretion to a liquid-mixed meal in NIDDM patients. RESEARCH DESIGN AND METHODS - Two prospective, randomized, double-blind, placebo-controlled, multicenter clinical trials were performed in 22 sites and 347 patients with NIDDM (aged 59 +/- 0.6 years; BMI, 29 +/- 0.3 kg/m(2); known diabetes duration, 8 +/- 0.4 years) were studied. Each clinical trial had a duration of 16 weeks with a 1-week washout, 3-week single-blind placebo phase, 4-week titration to a fixed dose, and 8-week maintenance phase at the assigned dose. In the first trial, once-daily doses of 5, 20, 40, or 60 mg glipizide GITS were compared with placebo in 143 patients. In the second trial, doses of 5, 10, 15, or 20 mg of glipizide GITS were compared with placebo in 204 patients. HbA(1c), fasting plasma glucose (FPG), insulin, C-peptide, and glipizide levels were determined at regular intervals throughout the study Postprandial plasma glucose (PPG), insulin, and C-peptide also were determined at 1 and 2 h after a mixed meal (Sustacal). RESULTS - All doses of glipizide GITS in both trials produced significant reductions from placebo in FPG (range -57 to - 74 mg/dl) and HbA(1c) (range - 1.50 to -1.82%). Pharmacodynamic analysis indicated a significant relationship between plasma glipizide concentration and reduction in FPG and HbA(1c) over a dose range of 5-60 mg, with maximal efficacy achieved at a dose of 20 mg for FPG and at 5 mg for HbA(1c). PPG levels were significantly lower, and both postprandial insulin and C-peptide levels significantly higher in patients treated with glipizide GITS compared with placebo. The percent reduction in FPG was comparable across patients with diverse demographic and clinical characteristics, including those with entry FPG greater than or equal to 250 mg/dl, resulting in greater absolute decreases in FPG and HbA(1c) in patients with the most severe hyperglycemia. Despite the forced titration to a randomly assigned dose, only ii patients in both studies discontinued therapy because of hypoglycemia. Glipizide GITS did not alter lipids levels or produce weight gain. CONCLUSIONS - The once-daily glipizide GITS 1) lowered HbA(1c), FPG, and PPG over a dose range of 5-60 mg, 2) was maximally effective at 5 mg (using HbA(1c)) or 20 mg (using FPG) based on pharmacokinetic and pharmacodynamic relationships, 3) maintained its effectiveness in poorly controlled patients (those with entry FPG greater than or equal to 250 mg/dl), 4) was safe and well tolerated in a wide variety of patients with NIDDM, and 5) did not produce weight gain or adversely affect lipids. C1 BRIGHAM & WOMENS HOSP,JOSLIN DIABET CTR,DEPT MED,BOSTON,MA 02115. HARVARD UNIV,SCH MED,BOSTON,MA 02115. PFIZER INC,NEW YORK,NY. DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710. ALBERT EINSTEIN COLL MED,DEPT MED,BRONX,NY 10467. ENDOCRINE ASSOCIATES DALLAS,DALLAS,TX. ALTON OCHSNER MED FDN & OCHSNER CLIN,NEW ORLEANS,LA. WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT INTERNAL MED,WINSTON SALEM,NC 27103. WALTER REED ARMY MED CTR,ENDOCRINE METABOL SERV,WASHINGTON,DC 20307. DUKE UNIV,DURHAM,NC 27706. NW RES ASSOCIATES INC,PORTLAND,DORSET,ENGLAND. W LOS ANGELES VET AFFAIRS MED CTR,LOS ANGELES,CA 90073. BEAUMONT HOSP,BIRMINGHAM,AL. LANSDALE MED GRP,LANSDALE,PA. ORLANDO CLIN RES CTR,ORLANDO,FL. ST LUKES ROOSEVELT HOSP,DIV ENDOCRINOL DIABET & METAB,NEW YORK,NY. CLIN RES CTR,SAN ANTONIO,TX. CTR STRESS STUDIES,SAN DIEGO,CA. DIABET & GLANDULAR DIS CLIN,SAN ANTONIO,TX. MONTEFIORE MED CTR,BRONX,NY 10467. JACKSON MEM HOSP,MIAMI,FL 33136. NW RES ASSOCIATES INC,PORTLAND,OR. OI Shamoon, Harry/0000-0002-5014-5211 NR 62 TC 93 Z9 98 U1 0 U2 6 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1660 DUKE ST, ALEXANDRIA, VA 22314 SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD APR PY 1997 VL 20 IS 4 BP 597 EP 606 DI 10.2337/diacare.20.4.597 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA WP645 UT WOS:A1997WP64500027 PM 9096986 ER PT J AU Surr, RK Cord, MT Walden, BE AF Surr, RK Cord, MT Walden, BE TI Comparison of linear and K-Amp(TM) circuits SO EAR AND HEARING LA English DT Article; Proceedings Paper CT 1993 Convention of the American-Academy-of-Audiology CY APR, 1993 CL PHOENIX, AZ SP Amer Acad Audiol ID HEARING-AID AB Objective: To evaluate hearing aid user preference for Linear Class D or Class D with K-Amp(TM) circuit. Design: Eighteen subjects, experienced with Class A hearing aid use, were given a choice of binaural hearing aids with either Linear Class D circuits or Class D with K-Amp(TM) circuits after consecutive 30 day trial periods with each set of instruments. The patients also rated the benefit obtained from each circuit using the Profile of Hearing Aid Benefit (PHAB). Results: There was no significant difference in the number of subjects who chose one or the other of the circuits. Further, the PHAB scores showed no statistically significant differences between the two circuits. In most cases, the instruments rated highest on each of the subscales by an individual subject were also the ones preferred based on the 30 day trial. Conclusions: Hearing aids with either Class D Linear or Class D with K-Amp(TM) circuits provided significant benefit in many everyday listening environments for individuals with a mild to moderate degree of hearing loss. Subjective choice between the Linear Class D and the K-Amp(TM) circuits was relatively evenly divided. RP Surr, RK (reprint author), WALTER REED ARMY MED CTR,ARMY AUDIOL & SPEECH CTR,WASHINGTON,DC 20307, USA. NR 20 TC 3 Z9 3 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0196-0202 J9 EAR HEARING JI Ear Hear. PD APR PY 1997 VL 18 IS 2 BP 140 EP 146 DI 10.1097/00003446-199704000-00006 PG 7 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA WR740 UT WOS:A1997WR74000006 PM 9099563 ER PT J AU Schmaljohn, C Hjelle, B AF Schmaljohn, C Hjelle, B TI Hantaviruses: A global disease problem SO EMERGING INFECTIOUS DISEASES LA English DT Article ID KOREAN HEMORRHAGIC-FEVER; PULMONARY SYNDROME; RENAL SYNDROME; ETIOLOGIC AGENT; HANTAAN VIRUS; NEPHROPATHIA EPIDEMICA; FAMILY BUNYAVIRIDAE; UNITED-STATES; OUTBREAK; VOLES AB Hantaviruses are carried by numerous rodent species throughout the world. In 1993, a previously unknown group of hantaviruses emerged in the United States as the cause of an acute respiratory disease now termed hantavirus pulmonary syndrome (HPS). Before then, hantaviruses were known as the etiologic agents of hemorrhagic fever with renal syndrome, a disease that occurs almost entirely in the Eastern Hemisphere. Since the discovery of the HPS-causing hantaviruses, intense investigation of the ecology and epidemiology of hantaviruses has led to the discovery of many other novel hantaviruses. Their ubiquity and potential for causing severe human illness make these viruses an important public health concern; we reviewed the distribution, ecology, disease potential, and genetic spectrum. C1 UNIV NEW MEXICO, ALBUQUERQUE, NM 87131 USA. RP Schmaljohn, C (reprint author), USA, MED RES INST INFECT DIS, DIV VIROL, FT DETRICK, FREDERICK, MD 21702 USA. NR 72 TC 640 Z9 705 U1 6 U2 38 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD APR-JUN PY 1997 VL 3 IS 2 BP 95 EP 104 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA XL155 UT WOS:A1997XL15500002 PM 9204290 ER PT J AU Sterling, K AF Sterling, K TI Saving wildlife: A century of conservation - Goddard,D SO ENVIRONMENTAL HISTORY LA English DT Book Review RP Sterling, K (reprint author), USA,COMBINED ARMS SUPPORT COMMAND,FT LEE,VA 23801, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ENVIRONMENTAL HISTORY PI DURHAM PA 701 VICKERS AVE, DURHAM, NC 27701-3147 SN 1084-5453 J9 ENVIRON HIST JI Environ. Hist. PD APR PY 1997 VL 2 IS 2 BP 235 EP 236 DI 10.2307/3985522 PG 2 WC Environmental Studies; History SC Environmental Sciences & Ecology; History GA WY088 UT WOS:A1997WY08800019 ER PT J AU Brixie, JM Neilson, LM Kim, BJ Severin, BF AF Brixie, JM Neilson, LM Kim, BJ Severin, BF TI Bottle-in-bag technique for gas sampling with analysis by autoheadspace GC SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article AB A new (bottle-in-bag) method for sampling gases is presented, examined, and discussed. The bottle-in-bag (BIB) method has broad application in air pollution control, industrial hygiene, soil remediation, groundwater remediation, and biofiltration of industrial waste streams. The BiB method is more cost-effective than the Tedlar bag capture method and allows analysis by autoheadspace GC. The method entails pumping the gas source and injecting it into a standard 22-mL headspace vial, held within a Ziploc bag, followed by crimp sealing of the bottle through the sealed bag. Gases from three separate sources (isobutylene calibration gas and pilot- and field-scale biofilter gas) were sampled to test the accuracy and precision of the BiB method under different sampling conditions. The BiB method was compared to the Tedlar bag and manual gas syringe methods. Sampling with the BIB technique produced results that were more accurate (recoveries of 98% and greater) and precise (coefficients of variability as low as 0.006) than the other methods, Highly reproducible and accurate results, even when the samples were subjected to temperature extremes and the rigors of airplane travel, are a strength of the BIB method, which combined with its simplicity and cost-effectiveness give it the potential for wide use. C1 MBI INT,LANSING,MI 49010. USA,CERL,EPD,CHAMPAIGN,IL 61826. NR 6 TC 3 Z9 3 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD APR PY 1997 VL 31 IS 4 BP 1224 EP 1228 DI 10.1021/es960758b PG 5 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA WR546 UT WOS:A1997WR54600065 ER PT J AU Dawson, NA McLeod, DG AF Dawson, NA McLeod, DG TI The assessment of treatment outcomes in metastatic prostate cancer: Changing endpoints SO EUROPEAN JOURNAL OF CANCER LA English DT Article ID BONE-SCAN; PROGNOSTIC-SIGNIFICANCE; ENDOCRINE TREATMENT; ACID-PHOSPHATASE; HORMONAL-THERAPY; ANTIGEN; QUALITY; LIFE; CARCINOMA; ORCHIECTOMY C1 WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP Dawson, NA (reprint author), WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 46 TC 19 Z9 20 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0959-8049 J9 EUR J CANCER JI Eur. J. Cancer PD APR PY 1997 VL 33 IS 4 BP 560 EP 565 DI 10.1016/S0959-8049(96)00443-1 PG 6 WC Oncology SC Oncology GA WZ557 UT WOS:A1997WZ55700021 PM 9274435 ER PT J AU Fink, LBR Temple, MHT Chiricosta, MFM Mizel, MS Murphey, MD AF Fink, LBR Temple, MHT Chiricosta, MFM Mizel, MS Murphey, MD TI Chondroblastoma of the foot SO FOOT & ANKLE INTERNATIONAL LA English DT Article AB A total of 322 cases of chondroblastoma were referred to the Armed Forces Institute of Pathology between 1960 and 1990. Ten additional cases of chondroblastoma were treated at Waiter Reed Army Medical Center between 1985 and 1993. Forty-two of these involved the foot, two of which were treated at Waiter Reed Army Medical Center. Patients with chondroblastoma of the foot were male in 35 (81%) cases, with a mean age of 25.5 years, which was significantly different from the mean age of 17.3 years in patients with chondroblastoma of the long bones (P < 0.0001). Chondroblastoma of the foot is most commonly found in the posterior subchondral areas of the talus and calcaneus as well as in the calcaneal apophysis. Radiographically, the lesion was associated with an articular surface or apophyseal area in all cases and appeared radiolucent, with little to no matrix production. The margins were generally well defined. Cystic features were noted grossly and histologically in 24 (57%) specimens, a feature seen in only 21% of all chondroblastomas overall. Treatment consists of thorough curetting and bone grafting with good oncologic and functional results. C1 PORTSMOUTH NAVAL HOSP,DEPT ORTHOPAED SURG,PORTSMOUTH,VA. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD 21218. ARMED FORCES INST PATHOL,BONE RADIOL DIV,WASHINGTON,DC 20306. NR 19 TC 17 Z9 18 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD APR PY 1997 VL 18 IS 4 BP 236 EP 242 PG 7 WC Orthopedics SC Orthopedics GA WU799 UT WOS:A1997WU79900010 ER PT J AU Hirota, WK Loughney, TM Lazas, DJ Maydonovitch, CL Rholl, V Wong, RKH AF Hirota, WK Loughney, TM Lazas, DJ Maydonovitch, CL Rholl, V Wong, RKH TI Short segment Barrett's esophagus and specialized intestinal metaplasia at the esophagogastric junction: Serial endoscopic and histologic assessment after acid suppression with omeprazole. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1997 VL 112 IS 4 SU S BP A577 EP A577 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WV419 UT WOS:A1997WV41902300 ER PT J AU Hirota, WK Loughney, TM Lazas, DJ Maydonovitch, CL Rholl, V Wong, RKH AF Hirota, WK Loughney, TM Lazas, DJ Maydonovitch, CL Rholl, V Wong, RKH TI The prevalence, clinical characteristics and incidence of dysplasia in short segment Barrett's' esophagus: A prospective cohort of 889 patients. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1997 VL 112 IS 4 SU S BP A577 EP A577 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WV419 UT WOS:A1997WV41902298 ER PT J AU Hirota, WK Loughney, TM Lazas, DJ Maydonovitch, CL Wong, RKH AF Hirota, WK Loughney, TM Lazas, DJ Maydonovitch, CL Wong, RKH TI Is Helicobacter pylori associated with specialized intestinal metaplasia of the esophagus or stomach? A prospective study of 889 patients. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NR 0 TC 18 Z9 18 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1997 VL 112 IS 4 SU S BP A149 EP A149 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WV419 UT WOS:A1997WV41900592 ER PT J AU Hirota, WK Loughney, TM Lazas, DJ Maydonovitch, CL Rholl, V Wong, RKH AF Hirota, WK Loughney, TM Lazas, DJ Maydonovitch, CL Rholl, V Wong, RKH TI The prevalence and demographics of specialized intestinal metaplasia at the esophagogastric junction in a cohort of 889 prospectively studied patients. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NR 0 TC 18 Z9 18 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1997 VL 112 IS 4 SU S BP A149 EP A149 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WV419 UT WOS:A1997WV41900591 ER PT J AU Parker, AL Kadakia, SC AF Parker, AL Kadakia, SC TI Hair iron and body iron storage status. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR, GASTROENTEROL SERV, SAN ANTONIO, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1997 VL 112 IS 4 SU S BP A1354 EP A1354 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WV419 UT WOS:A1997WV41905400 ER PT J AU Riel, MA Williams, D Brinkley, WW Kadakia, SC AF Riel, MA Williams, D Brinkley, WW Kadakia, SC TI The effect of deferoxamine on carbon tetrachloride induced cirrhosis in the rat. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR, SAN ANTONIO, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1997 VL 112 IS 4 SU S BP A1366 EP A1366 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WV419 UT WOS:A1997WV41905446 ER PT J AU Semancik, G McQueen, C Lowell, G PineiroCarrero, V Wolf, M Cassels, F Fleming, E Tseng, LY Mallett, C AF Semancik, G McQueen, C Lowell, G PineiroCarrero, V Wolf, M Cassels, F Fleming, E Tseng, LY Mallett, C TI Intranasal immunization with proteosomes containing adherence pili from rabbit E-coli diarrheal strain RDEC-1. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. INTELLIVAX INC, BALTIMORE, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1997 VL 112 IS 4 SU S BP A1088 EP A1088 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WV419 UT WOS:A1997WV41904338 ER PT J AU Shaffer, R Szyjkowski, R McNerney, J Melo, M Carrougher, J Kadakia, S AF Shaffer, R Szyjkowski, R McNerney, J Melo, M Carrougher, J Kadakia, S TI Effect of omeprazole vs misoprostol in prevention of acute aspirin induced gastric injury. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR, DEPT MED, GASTROENTEROL SERV, SAN ANTONIO, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1997 VL 112 IS 4 SU S BP A286 EP A286 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WV419 UT WOS:A1997WV41901138 ER PT J AU Wong, PWK Howden, J Parker, AL Kadakia, SC AF Wong, PWK Howden, J Parker, AL Kadakia, SC TI Manometric findings in 3 subjects with multiple esophageal rings. SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR, SAN ANTONIO, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1997 VL 112 IS 4 SU S BP A333 EP A333 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WV419 UT WOS:A1997WV41901328 ER PT J AU Hirota, WK Wortmann, G Maydonovitch, CL Chang, AS Midkiff, R Tsapakos, M Wong, RKH Moses, F AF Hirota, WK Wortmann, G Maydonovitch, CL Chang, AS Midkiff, R Tsapakos, M Wong, RKH Moses, F TI The effect of oral decontamination with clindamycin palmitate on the incidence of bacteremia after esophageal dilation: A prospective trial SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD APR PY 1997 VL 45 IS 4 SU S BP 96 EP 96 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WU214 UT WOS:A1997WU21400096 ER PT J AU Szyjkowski, R Shaffer, R Kadakia, S AF Szyjkowski, R Shaffer, R Kadakia, S TI Frequency of endoscopic and histologic short segment Barrett's epithelium (SSBE) in patients with treated achalasia. SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,GASTROENTEROL SERV,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD APR PY 1997 VL 45 IS 4 SU S BP 244 EP 244 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WU214 UT WOS:A1997WU21400244 ER PT J AU Rizvi, SA Nasrabadi, NM AF Rizvi, SA Nasrabadi, NM TI Finite-state residual vector quantization using a tree-structured competitive neural network SO IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY LA English DT Article DE competitive neural network; image coding; joint optimization; multilayer perceptron; vector quantization AB Finite-state vector quantization (FSVQ) is known to give better performance than the memoryless vector quantization (VQ). This paper presents a new FSVQ scheme, called finite-state residual vector quantization (FSRVQ), in which each state uses a residual vector quantizer (RVQ) to encode the input vector, This scheme differs from the conventional FSVQ in that the state-RVQ codebooks encode the residual vectors instead of the original vectors, A neural network predictor estimates the current block based on the four previously encoded blocks, The predicted vector is then used to identify the current state as well as to generate a residual vector (the difference between the current vector and the predicted vector), This residual vector is encoded using the current state-RVQ codebooks, A major task in designing our proposed FSRVQ is the joint optimization of the next-state codebook and the state-RVQ codebooks, This is achieved by introducing a novel tree-structured competitive neural network in which the first layer implements the next-state function, and each branch of the tree implements the corresponding state-RVQ, A joint training algorithm is also developed that mutually optimizes the next-state and the state-RVQ codebooks for the proposed FSRVQ, Joint optimization of the next-state function and the state-RVQ codebooks eliminates a large number of redundant states in the conventional FSVQ design; consequently, the memory requirements are substantially reduced in the proposed FSRVQ scheme, The proposed FSRVQ can be designed for high bit rates due to its very low memory requirements and the low search complexity of the state-RVQ's, Simulation results show that the proposed FSRVQ scheme outperforms conventional FSVQ schemes both in terms of memory requirements and the visual quality of the reconstructed image. The proposed FSRVQ scheme also outperforms JPEG (the current standard for still image compression) at low bit rates. C1 USA,RES LAB,ADELPHI,MD 20783. RP Rizvi, SA (reprint author), CUNY COLL STATEN ISL,DEPT APPL SCI,STATEN ISL,NY 10314, USA. NR 19 TC 5 Z9 5 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1051-8215 J9 IEEE T CIRC SYST VID JI IEEE Trans. Circuits Syst. Video Technol. PD APR PY 1997 VL 7 IS 2 BP 377 EP 390 DI 10.1109/76.564114 PG 14 WC Engineering, Electrical & Electronic SC Engineering GA WR977 UT WOS:A1997WR97700009 ER PT J AU Tang, YH Hunt, RT Robertazzi, R Fisher, MA Coughlin, J Patt, R Track, EK Potenziani, E AF Tang, YH Hunt, RT Robertazzi, R Fisher, MA Coughlin, J Patt, R Track, EK Potenziani, E TI Cryocooled primary voltage standard system SO IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT LA English DT Article; Proceedings Paper CT Conference on Precision Electromagnetic Measurements (CPEM 96) CY JUN 17-20, 1996 CL BRAUNSCHWEIG, GERMANY AB The primary voltage standard system based on the Josephson junction array (JJA) produces the ultimate in accuracy for de voltage calibration, Hen-ever, it is only used in the highest le, el standards laboratories due to the expense and inconvenience of liquid helium cooling, In cooperation with the US Army Research Laboratory, HYPRES has developed a mobile JJA primary voltage standard system using a closed cycle refrigerator (CCR), The system performance is comparable to a conventional liquid helium system, The elimination of liquid helium makes the mobile system not only more economically attractive, but also more convenient to use, The mobile JJA voltage standard system is very suitable for users who lack access to liquid helium, and for those who require transportability. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP Tang, YH (reprint author), HYPRES INC,175 CLEARBROOK RD,ELMSFORD,NY 10523, USA. NR 2 TC 16 Z9 16 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9456 J9 IEEE T INSTRUM MEAS JI IEEE Trans. Instrum. Meas. PD APR PY 1997 VL 46 IS 2 BP 256 EP 259 DI 10.1109/19.571826 PG 4 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA WY149 UT WOS:A1997WY14900042 ER PT J AU Jones, JR Bishop, WL Jones, SH Tait, GB AF Jones, JR Bishop, WL Jones, SH Tait, GB TI Planar multibarrier 80/240-GHz heterostructure barrier varactor triplers SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article DE frequency conversion; millimeter-wave diodes; semiconductor heterojunctions; varactors ID WAVE MULTIPLIERS; MILLIMETER-WAVE; OHMIC CONTACTS; SIMULATION; DIODES; GAAS AB Prototype planar four barrier GaAs/Al(0.7)Gao(0.3)As heterostructure barrier varactors (HBV's) for frequency tripling from 80 to 240 GHz have been fabricated using a process in which the device surface channnel is etched prior to the formation of the contact pad-to-anode air-bridge finger, Formation of the device air-bridge finger after etching the surface channel is facilitated by a trench planarization technique and yields a device with minimal parasitic capacitances, Planar four-barrier HBV triplers with nominal 10-mu m diameter anodes have been tested in a crossed-waveguide tripler block; as much as 2 mW of power has been generated at 252 GHz with a flange-to-flange tripling efficiency of 2.5%, These devices are the first planar or multibarrier HBV triplers reported and their output powers are nearly double that of previous whisker-contacted single-barrier HBV's. C1 UNIV VIRGINIA,DEPT ELECT ENGN,CHARLOTTESVILLE,VA 22903. US MIL ACAD,DEPT COMP SCI & ELECT ENGN,W POINT,NY 10996. NR 16 TC 38 Z9 40 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD APR PY 1997 VL 45 IS 4 BP 512 EP 518 DI 10.1109/22.566631 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA WR586 UT WOS:A1997WR58600007 ER PT J AU Schoenberg, JSH Burger, JW Tyo, JS Abdalla, MD Skipper, MC Buchwald, WR AF Schoenberg, JSH Burger, JW Tyo, JS Abdalla, MD Skipper, MC Buchwald, WR TI Ultra-wideband source using gallium arsenide photoconductive semiconductor switches SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article AB An ultrawide-band (UWB) pulse generator based on high gain (lock-on mode) gallium arsenide (GaAs) photoconductive semiconductor switches (PCSS's) is presented, Revised PCSS contact design shows improved performance in hold-off field, on-state switch potential, and switching jitter, while reducing the switch volume by 75% compared to previous designs. A compact laser diode module operates at 904 nm and triggers the PCSS at pulse repetition rates (PRR) of up to 2 kHz. The 625 W laser diode output power is found to be sufficient to produce switching jitter of 65 ps rms at a switched field of 80 kV/cm, The PCSS switching jitter is found to have a strong dependence upon the switched field when triggered with the laser diode module, The revised PCSS geometry is easily integrated into a compact, parallel-plate source used to drive a TEM horn impulse-radiating antenna (IRA), The radiated field has a rise time of 330 ps and an adjustable low-frequency spectrum. C1 MAXWELL TECHNOL,FED DIV,ALBUQUERQUE,NM 87119. USA,RES LAB,ED,EP,AMSRL,FT MONMOUTH,NJ 07703. RP Schoenberg, JSH (reprint author), USAF,PHILLIPS LAB,ADV WEAP & SURVIVABIL DIRECTORATE,WSQW,KIRTLAND AFB,NM 87117, USA. NR 13 TC 51 Z9 67 U1 0 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD APR PY 1997 VL 25 IS 2 BP 327 EP 334 DI 10.1109/27.602507 PG 8 WC Physics, Fluids & Plasmas SC Physics GA XK560 UT WOS:A1997XK56000029 ER PT J AU Gretz, JE Anderson, AO Shaw, S AF Gretz, JE Anderson, AO Shaw, S TI Cords, channels, corridors and conduits: Critical architectural elements facilitating cell interactions in the lymph node cortex SO IMMUNOLOGICAL REVIEWS LA English DT Review ID HIGH-ENDOTHELIAL VENULES; PEYERS-PATCHES; DEEP CORTEX; RAT; MIGRATION; LYMPHOCYTES; LOCALIZATION; TISSUE; POPULATIONS; MORPHOLOGY AB The lymph node cortex is a critical site for encounter between recirculating T cells and their specific antigens. Due to its extreme plasticity, Little is understood of the underlying functional unit of the lymph node cortex, the paracortical cord. The idealized paracortical cord (approximately 100 mu m by 1000 mu m) stretches from a medullary cord to the base of a B-cell follicle. In cross-section, a cord can be visualized as a set of nested cylinders consisting of spaces bounded by cells. The spaces are: i) the lumen of the high endothelial venule (HEV), ii) perivenular channels - narrow potential spaces (0.1 mu m) rightly encircling the HEV, iii) corridors - broad spaces (10-15 mu m) constituting the majority of the parenchyma, and iv) the cortical sinus. In addition to these spaces for cell traffic, the conduit (fifth space) is a special delivery system for the transit of soluble factors to the HEV and emigrating lymphocytes. The cellular barriers between these spaces are high endothelium, fibroblastic reticular cells, or sinus-lining cells. This review describes the spaces of the paracortical cord and their cellular boundaries, outlines the movement of cells and fluids through these spaces, and discusses how this anatomy affects the efficiency of surveillance by T cells. C1 NCI,EXPT IMMUNOL BRANCH,HUMAN IMMUNOL SECT,NIH,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,DEPT CLIN PATHOL,DIAGNOST SYST DIV,FT DETRICK,MD 21702. NR 78 TC 274 Z9 278 U1 0 U2 11 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0105-2896 J9 IMMUNOL REV JI Immunol. Rev. PD APR PY 1997 VL 156 BP 11 EP 24 DI 10.1111/j.1600-065X.1997.tb00955.x PG 14 WC Immunology SC Immunology GA WY221 UT WOS:A1997WY22100002 PM 9176696 ER PT J AU FernandezPrada, CM Hoover, DL Tall, BD Venkatesan, MM AF FernandezPrada, CM Hoover, DL Tall, BD Venkatesan, MM TI Human monocyte-derived macrophages infected with virulent Shigella flexneri in vitro undergo a rapid cytolytic event similar to oncosis but not apoptosis SO INFECTION AND IMMUNITY LA English DT Article ID PROGRAMMED CELL-DEATH; IL-1 RECEPTOR ANTAGONIST; EPITHELIAL-CELLS; MURINE MACROPHAGES; INTERLEUKIN-1; CLEAVAGE; DNA; FRAGMENTATION; CYTOKINES; ANTIBODY AB Infection of human monocyte-derived macrophages in vitro with virulent Shigella flexneri resulted in cell death which involved rupture of the plasma membrane, cell swelling, disintegration of ultrastructure, and generalized karyolysis, These features bore resemblance to oncosis and are in striking contrast to previously described observations of mouse macrophages, where a similar infection by virulent Shigella resulted in cell death by apoptosis, Cell death by oncosis in human macrophages was confirmed by lactate dehydrogenase release, light microscopy, electron microscopy, terminal deoxynucleotidyltransferase end labeling of DNA ends, DNA fragmentation assays, and fluorescence-activated cell sorter analysis of propidium-labeled nuclei. Thus, the phenomena of cell death induced by virulent Shigella in human and mouse macrophages reflect different biochemical pathways. Interleukin-1 beta (IL-1 beta) was released in culture supernatants of human macrophages infected with virulent bacteria, Inhibition with IL-lp-converting enzyme inhibitors indicated, however, that this release occurred as a passive event of cell lysis, The patterns of intracellular survival of Shigella strains within human and mouse macrophages reflect differences that exist not only between Shigella serotypes but also between the two different macrophage cell types. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTER INFECT,DIV COMMUN DIS & IMMUNOL,WASHINGTON,DC 20307. GEORGE WASHINGTON UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,WASHINGTON,DC 20204. US FDA,CTR FOOD SAFETY & APPL NUTR,MICROBIAL ECOL BRANCH,WASHINGTON,DC 20204. OI Tall, Ben/0000-0003-0399-3629 NR 51 TC 60 Z9 65 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 1997 VL 65 IS 4 BP 1486 EP 1496 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA WQ298 UT WOS:A1997WQ29800049 PM 9119491 ER PT J AU Reichenbach, SE Park, SK Howe, JD AF Reichenbach, SE Park, SK Howe, JD TI Restoration and range performance in FLIR imaging systems SO INFRARED PHYSICS & TECHNOLOGY LA English DT Article ID INFORMATION; CONVOLUTION; FIDELITY AB Image restoration of forward-looking infrared (FLIR) imagery has the potential to significantly improve the quality of images used by an automatic target recognizer (ATR) or human observer. This study investigates the feasibility of real-time image restoration algorithms and the problem of measuring image quality as it relates to target acquisition performance. This paper describes a technique for deriving small kernel filters that efficiently restore and reconstruct. Subject to implementation constraints associated with efficient application, the filters optimize image fidelity to an 'ideal' close-range image, The paper describes simulation experiments employing an end-re-end imaging system model, experiments with actual images using a model-based characterization of an actual imaging system, and simulation experiments that illustrate the utility of the system model and filtering in FLIR imaging system design. (C) 1997 Published by Elsevier Science B.V. C1 COLL WILLIAM & MARY,DEPT COMP SCI,WILLIAMSBURG,VA 23185. USA,NIGHT VIS & ELECT SENSORS DIRECTORATE,FT BELVOIR,VA 22060. RP Reichenbach, SE (reprint author), UNIV NEBRASKA,DEPT COMP SCI & ENGN,LINCOLN,NE 68588, USA. NR 29 TC 1 Z9 1 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 1350-4495 J9 INFRARED PHYS TECHN JI Infrared Phys. Technol. PD APR PY 1997 VL 38 IS 3 BP 177 EP 192 DI 10.1016/S1350-4495(96)00039-4 PG 16 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA WV228 UT WOS:A1997WV22800008 ER PT J AU Kolka, MA Stephenson, LA AF Kolka, MA Stephenson, LA TI Effect of luteal phase elevation in core temperature on forearm blood flow during exercise SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE body temperature regulation ID MENSTRUAL-CYCLE; POSTMENOPAUSAL WOMEN; BODY-TEMPERATURE; ESTROGEN; VASODILATION; MECHANISMS; RESPONSES; NIGHT AB Forearm blood flow (FBF) as an index of skin blood flow in the forearm was measured in five healthy women by venous occlusion plethysmography during leg exercise at 80% peak aerobic power and ambient temperature of 35 degrees C (relative humidity 22%; dew-point temperature 10 degrees C). Resting esophageal temperature (T-es) was 0.3 +/- 0.1 degrees C higher in the midluteal than in the early follicular phase of the menstrual cycle (P < 0.05). Resting FBF was not different between menstrual cycle phases. The T-es threshold for onset of skin vasodilation was higher (37.4 +/- 0.2 degrees C) in midluteal than in early follicular phase (37.0 +/- 0.1 degrees C; P < 0.05). The slope of the FBF to T-es relationship was not different between menstrual cycle phases (14.0 +/- 4.2 ml . 100 ml(-1). min(-1).degrees C-1 for early follicular and 16.3 +/- 3.2 ml . 100 ml(-1). min(-1).degrees C-1 for midluteal phase). Plateau FBF was higher during exercise in midluteal (14.6 +/- 2.2 ml . 100 ml(-1). min(-1).degrees C-1) compared with early follicular phase (10.9 +/- 2.4 ml . 100 ml(-1). min(-1).degrees C-1; P < 0.05). The attenuation of the increase in FBF to T-es occurred when T-es was 0.6 degrees C higher and at higher FBF in midluteal than in early follicular experiments (P < 0.05). In summary, the FBF response is different during exercise in the two menstrual cycle phases studied. After the attenuation of the increase in FBF and while T-es was still increasing, the greater FBF in the midluteal phase may have been due to the effects of increased endogenous reproductive endocrines on the cutaneous vasculature. RP Kolka, MA (reprint author), USA,ENVIRONM MED RES INST,THERMAL & MT MED DIV,KANSAS ST,NATICK,MA 01760, USA. NR 29 TC 39 Z9 39 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD APR PY 1997 VL 82 IS 4 BP 1079 EP 1083 PG 5 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA WT038 UT WOS:A1997WT03800009 PM 9104842 ER PT J AU Chapman, MW Bucholz, R Cornell, C AF Chapman, MW Bucholz, R Cornell, C TI Treatment of acute fractures with a collagen-calcium phosphate graft material - A randomized clinical trial SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID BONE; DEFECTS AB A prospective, randomized clinical trial was conducted concurrently at eighteen medical centers in order to compare the safety and efficacy of two types of graft material for the treatment of fractures of long bones: autogenous bone graft obtained from the iliac crest, and a composite material composed of purified bovine collagen, a biphasic calcium-phosphate ceramic, and autogenous marrow, Two hundred and thirteen patients (249 fractures) were followed for a minimum of twenty-four months to monitor healing and the occurrence of complications. We observed no significant differences between the two treatment groups with respect to rates of union (p = 0.94, power = 88 per cent) or functional measures (use of analgesics, pain with activities of daily living, and impairment in activities of daily living; p > 0.10). The prevalence of complications did not differ between the treatment groups except for the rate Of infection, which was higher in the patients who were managed with an autogenous graft. Twelve patients who were managed with a synthetic graft had a positive antibody titer to bovine collagen; seven of them agreed to have intradermal challenge with bovine collagen, One patient had a positive skin response to the challenge but had no complications with regard to healing of the fracture. We concluded that, for traumatic defects of long bones that necessitate grafting, use of the composite graft material appears to be justified on the grounds of safety, efficacy, and elimination of the increased operative time and risk involved in obtaining an autogenous graft from the iliac crest. C1 ST PAUL RAMSEY MED CTR,ST PAUL,MN 55101. HERMANN HOSP,HOUSTON,TX. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. HENNEPIN CTY MED CTR,MINNEAPOLIS,MN. UNIV MISSISSIPPI,MED CTR,JACKSON,MS 39216. HAMOT MED CTR,ERIE,PA. SAN BERNARDINO CTY MED CTR,SAN BERNARDINO,CA. ERIE CTY MED CTR & LABS,ERIE,PA. WILLIAM WISHARD MEM HOSP,INDIANAPOLIS,IN. REG MED CTR,MEMPHIS,TN. UNIV LOUISVILLE,HUMANA HOSP,LOUISVILLE,KY 40292. GERMANTOWN HOSP & MED CTR,PHILADELPHIA,PA. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. TAMPA GEN HOSP,TAMPA,FL 33606. UNIV CALIF DAVIS,MED CTR,DEPT ORTHOPAED SURG,SACRAMENTO,CA 95817. UNIV TEXAS,SW MED CTR,DALLAS,TX 75235. HOSP SPECIAL SURG,NEW YORK,NY 10021. RP Chapman, MW (reprint author), UNIV CALIF SAN DIEGO,SAN DIEGO,CA 92103, USA. NR 15 TC 130 Z9 140 U1 1 U2 5 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD APR PY 1997 VL 79A IS 4 BP 495 EP 502 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA WU515 UT WOS:A1997WU51500004 PM 9111393 ER PT J AU Gorte, RJ White, D Biaglow, AI Farneth, WE Sepa, J AF Gorte, RJ White, D Biaglow, AI Farneth, WE Sepa, J TI Solid acids and acids in solution: The reversible transfer of hydrons to carbonyl groups - Reply SO JOURNAL OF CATALYSIS LA English DT Letter ID C-13 CHEMICAL-SHIFT; ACETONE; H-ZSM-5; ZEOLITE; SITES C1 UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104. US MIL ACAD,DEPT CHEM,W POINT,NY 10996. DUPONT CO INC,CENT RES & DEV,EXPT STN 356 307,WILMINGTON,DE 19880. RP Gorte, RJ (reprint author), UNIV PENN,DEPT CHEM ENGN,PHILADELPHIA,PA 19104, USA. NR 20 TC 5 Z9 5 U1 0 U2 7 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0021-9517 J9 J CATAL JI J. Catal. PD APR 1 PY 1997 VL 167 IS 1 BP 300 EP 302 DI 10.1006/jcat.1997.1597 PG 3 WC Chemistry, Physical; Engineering, Chemical SC Chemistry; Engineering GA WV164 UT WOS:A1997WV16400032 ER PT J AU Takimoto, CH Dahut, W Marino, MT Nakashima, H Liang, MD Harold, N Lieberman, R Arbuck, SG Band, RA Chen, AP Hamilton, JM Cantilena, LR Allegra, CJ Grem, JL AF Takimoto, CH Dahut, W Marino, MT Nakashima, H Liang, MD Harold, N Lieberman, R Arbuck, SG Band, RA Chen, AP Hamilton, JM Cantilena, LR Allegra, CJ Grem, JL TI Pharmacodynamics and pharmacokinetics of a 72-hour infusion of 9-aminocamptothecin in adult cancer patients SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID TOPOISOMERASE-I INHIBITOR; PHASE-I; CAMPTOTHECIN; TOPOTECAN; CPT-11; XENOGRAFTS; ANALOGS; TRIAL AB Purpose: To investigate the pharmacokinetics and pharmacodynamics of 9-aminocamptothecin (9-AC) infused over 72 hours at doses of 5 to 74 mu g/m(2)/h. Patients and Methods: 9-AC lactone and total (lactone plus carboxylate) plasma concentrations were measured in 44 patients with solid tumors using a high-performance liquid chromatography (HPLC) assay, Fifteen patients underwent extended pharmacokinetic sampling to determine the distribution and elimination kinetics of 9-AC. Results: At steady-state, 8.7% +/- 4.7% (mean +/- SD) of the totes drug circulated in plasma as the active 9-AC lactone, Clearance of 9-AC lactone was uniform (24.5 +/- 7.3 L/h/m(2)) over the entire dose range examined; however, total 9-AC clearance was nonlinear and increased at higher dose levels, In 15 patients treated at dose levels greater than or equal to 47 mu g/m(2)/h, the volume of distribution at steady-state for 9-AC lactone was 195 +/- 114 L/m(2) and for total 9-AC if was 23.6 +/- 10.6 L/m(2). The elimination half-life was 4.47 +/- 0.53 hours for 9-AC lactone and 8.38 +/- 2.10 hours for total 9-AC. In pharmacodynamic studies, dose-limiting neurtropenia correlated with steady-state lactone concentrations (Css) (R-2 = .77) and drug dose (R-2 = .71). Conclusion: Plasma 9-AC concentrations rapidly declined to low levels following the end of a 72-hour infusion and the mean fraction of total 9-AC circulating in plasma as the active lactane was less than 10%. The pharmacokinetics of 9-AC may have a great impact on its clinical activity and should be considered in the design of future clinical trials of this topoisomerase I inhibitor. C1 NCI, CANC THERAPY EVALUAT PROGRAM, BETHESDA, MD 20892 USA. UNIFORMED SERV UNIV HLTH SCI, DEPT INTERNAL MED, DIV CLIN PHARMACOL, BETHESDA, MD 20814 USA. US FDA, CTR DRUG EVALUAT & RES, ROCKVILLE, MD 20857 USA. WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT PHARMACOL, DIV EXPT THERAPEUT, WASHINGTON, DC 20307 USA. RP Takimoto, CH (reprint author), NATL NAVAL MED CTR, NCI,NAVY MED ONCOL BRANCH,DIV CLIN SCI,BLDG 8, ROOM 5101, BETHESDA, MD 20889 USA. NR 26 TC 41 Z9 42 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD APR PY 1997 VL 15 IS 4 BP 1492 EP 1501 PG 10 WC Oncology SC Oncology GA WX651 UT WOS:A1997WX65100028 PM 9193345 ER PT J AU Clark, JY Kearse, WS AF Clark, JY Kearse, WS TI Extracorporeal shockwave lithotripsy for kidney stone on surgical clip SO JOURNAL OF ENDOUROLOGY LA English DT Article ID CONDUIT AB We report the successful use of extracorporeal shockwave lithotripsy for the destruction of a renal stone that had formed around a surgical clip. The SWL led to passage of both the stone and the clip. C1 WILFORD HALL USAF MED CTR,DEPT UROL,SAN ANTONIO,TX 78236. RP Clark, JY (reprint author), WOMACK ARMY MED CTR,DEPT SURG,UROL SERV,FT BRAGG,NC 28307, USA. OI Clark, Joseph/0000-0002-3817-4343 NR 4 TC 2 Z9 2 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0892-7790 J9 J ENDOUROL JI J. Endourol. PD APR PY 1997 VL 11 IS 2 BP 119 EP 120 DI 10.1089/end.1997.11.119 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA WT425 UT WOS:A1997WT42500004 PM 9107584 ER PT J AU McElhaney, JM Palazzolo, A Kascak, A AF McElhaney, JM Palazzolo, A Kascak, A TI Modeling and simulation methods for MDOF structures and rotating machinery with impact dampers SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 40th International Gas Turbine and Aeroengine Congress and Exhibition CY JUN 05-08, 1995 CL HOUSTON, TX AB Previously published work on applied impact damping typically relates to SDOF models or simple MDOF models such as the classical cantilever beam. Structural models often require an extremely large number of DOF with mode shapes that are generally very complex. Dynamics simulation of these typically becomes both complicated and time consuming. The nonlinear behavior of impact dampers further complicates such simulation in that standard linear solutions are not possible. The primary objective in this research extends previous work by applying impact dampers to MDOF structures that are modeled with general three-dimensional ''beam'' finite elements. Modal-based models of the MDOF systems and efficient impact damper tracking algorithms were also developed that significantly reduced CPU time for simulation. Significant among the objectives was obtaining an impact damper design for the MDOF casing structure of the Space Shuttle Main Engine (SSME), High-Pressure Oxygen Turbo-Pump (HPOTP), subject to pump rotor shaft unbalance, Impact damper performance is based on suppression of vibration at casing critical frequencies for rotor speed ranges, at rotor full speed, and vert high unbalance to simulate a defect such as losing an impeller blade fragment or a cracked bearing [6]. Simulations show significant reductions in vibration at the casing critical-frequencies and very high unbalance levels while little or no improvement was observed off resonance. Additionally, the previous work with an experimental rotor bearing system (RBS) and impact damper was modeled using the developed modal-based methods. Simulation of the resulting model response shows remarkable agreement with the experimental. Finally, both the RES and the HPOTP were modeled and simulated as unstable systems with attached impact dampers. The simulations predict that the impact damper is an excellent stabilizing mechanism for a range of instability driver values. Simulation of the models in this research with the developed modal based algorithms were accomplished with excellent efficiency, and accurate results. C1 NASA,LEWIS RES CTR,USA,CLEVELAND,OH 44135. RP McElhaney, JM (reprint author), TEXAS A&M UNIV,DEPT MECH ENGN,COLLEGE STN,TX 77843, USA. NR 2 TC 1 Z9 1 U1 0 U2 7 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD APR PY 1997 VL 119 IS 2 BP 436 EP 446 DI 10.1115/1.2815594 PG 11 WC Engineering, Mechanical SC Engineering GA WW751 UT WOS:A1997WW75100025 ER PT J AU Welch, GE Jones, SM Paxson, DE AF Welch, GE Jones, SM Paxson, DE TI Wave-rotor-enhanced gas turbine engines SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article AB The benefits of wave rotor topping in small (300- to 500-kW [400- to 700-hp] class) and intermediate (2000- to 3000-kW [3000- to 4000-hp] class) turboshaft engines, and large (350- to 450-kN [80,000- to 100,000-lb(f)] class) high-bypass-ratio turbofan engines are evaluated. Wave rotor performance levels are calculated using a one-dimensional design/analysis code. Baseline and wave-rotor-enhanced engine perfor mance levels are obtained from a cycle deck in which the wave rotor is represented as a burner with pressure gain. Nave rotor topping is shown to enhance the specific fuel consumption and specific power of small- and intermediate-sized turboshaft engines significantly. The specific fuel consumption of the wave-rotor-enhanced large turbofan engine can be reduced while it operates at a significantly reduced turbine inlet temperature. The wave-rotor-enhanced engine is shown to behave off-design like a conventional engine. Discussion concerning the impact of the wave rotor/gas turbine engine integration identifies technical challenges. C1 NASA,LEWIS RES CTR,CLEVELAND,OH 44135. RP Welch, GE (reprint author), USA,RES LAB,WASHINGTON,DC, USA. NR 24 TC 21 Z9 21 U1 0 U2 2 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD APR PY 1997 VL 119 IS 2 BP 469 EP 477 DI 10.1115/1.2815598 PG 9 WC Engineering, Mechanical SC Engineering GA WW751 UT WOS:A1997WW75100029 ER PT J AU Feldman, RM ElHarazi, SM LoRusso, FJ McCash, C Lloyd, WC Warner, PA AF Feldman, RM ElHarazi, SM LoRusso, FJ McCash, C Lloyd, WC Warner, PA TI Histopathologic findings following contact transscleral semiconductor diode laser cyclophotocoagulation in a human eye SO JOURNAL OF GLAUCOMA LA English DT Article C1 WILFORD HALL USAF MED CTR,SAN ANTONIO,TX 78236. BROOKE ARMY MED CTR,SAN ANTONIO,TX. RP Feldman, RM (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT OPHTHALMOL & VISUAL SCI,HERMANN EYE CTR,6411 FANNIN,7TH FLOOR,HOUSTON,TX 77030, USA. NR 2 TC 21 Z9 22 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1057-0829 J9 J GLAUCOMA JI J. Glaucoma PD APR PY 1997 VL 6 IS 2 BP 139 EP 140 PG 2 WC Ophthalmology SC Ophthalmology GA WR368 UT WOS:A1997WR36800011 PM 9098823 ER PT J AU Rinehart, TL Schulze, DG Bricka, RM Bajt, S Blatchley, ER AF Rinehart, TL Schulze, DG Bricka, RM Bajt, S Blatchley, ER TI Chromium leaching vs. oxidation state for a contaminated solidified/stabilized soil SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE chromium; contaminated soil; solidification/stabilization ID CHROMATE AB The toxicity, solubility, and mobility of chromium in soil are strongly dependent upon its oxidation state. Solidification/stabilization (S/S) is a potential method for preventing Cr leaching from contaminated soil. We evaluated the leaching behavior of untreated and solidified/stabilized chromium contaminated soil samples obtained from two locations al a military facility in Louisiana. The leaching of chromium, as measured by the Toxicity Characteristic Leaching Procedure (TCLP), was expected to be dependent upon the chromium oxidation state. The pH, cation exchange capacity and particle size distribution were obtained for each sample and portions of each sample were solidified with Type I Portland cement. The oxidation state of chromium was determined by X-ray absorption spectroscopy (XAS). The sample from Site 1 contained 478 mg kg(-1) total chromium while the sample from Site 2 contained 1272 mg kg(-1) total Cr. The TCLP chromium concentration for Site 1 untreated soil was 3.4 mg L-1 and 2.0 mg L-1 for the S/S treated sample. The sample from Site 2 had TCLP chromium concentrations below the analytical detection limit (<1.0 mg L-1) for both untreated and S/S samples. The XAS data showed the presence of the more mobile and soluble Cr+6 at Site 1 but not at Site 2, The use of Portland cement alone was not effective in reducing the Cr+6 to the less soluble and less mobile Cr+3, or in physically preventing leaching of Cr+6. (C) 1997 Elsevier Science B.V. C1 PURDUE UNIV, DEPT AGRON, W LAFAYETTE, IN 47907 USA. UNIV CHICAGO, CONSORTIUM ADV RADIAT SOURCES, BROOKHAVEN NATL LAB, UPTON, NY 11973 USA. PURDUE UNIV, SCH CIVIL ENGN, W LAFAYETTE, IN 47907 USA. RP Rinehart, TL (reprint author), USA, CORPS ENGINEERS, WATERWAYS EXPT STN, CEWES EE R, 3909 HALLS FERRY RD, VICKSBURG, MS 39180 USA. RI Bajt, Sasa/G-2228-2010 NR 16 TC 24 Z9 27 U1 5 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD APR PY 1997 VL 52 IS 2-3 BP 213 EP 221 DI 10.1016/S0304-3894(96)01808-0 PG 9 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA XF549 UT WOS:A1997XF54900005 ER PT J AU Malone, PG Poole, TS Wakeley, LD Burkes, JP AF Malone, PG Poole, TS Wakeley, LD Burkes, JP TI Salt related expansion reactions in Portland-cement-based wasteforms SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE expansion; salt-cement wasteform AB A small-scale study was conducted to investigate the expansion of a simulated salt-cement wasteform made with a salt mixture containing sodium nitrate, sodium sulfate, and sodium chloride blended with water and Type I Portland cement. The total salt loading was 39.4% by mass of simulated wasteform. Samples cured at 23 degrees C hardened within 90 h and showed strength averaging 11.67 MPa after 23 days. Samples cured at 23 degrees C and 55 degrees C expanded when subjected to temperature cycling from 1 to 25 degrees C. The samples cured at 55 degrees C required only four cycles to disintegrate after showing 14% expansion. Samples cured at 23 degrees C required eight cycles before disintegrating after showing 16% expansion. X-ray diffraction patterns from 1-, 4-, 6-, and 21-day-old samples showed the characteristic patterns of halite, sodium nitrate, darapskite, and unreacted Portland cement. Samples older than 1 day also showed portlandite, sodium sulfate and calcium chloroaluminate hydrate which were not found in the younger sample. The results are consistent with the hypothesis that expansion is due to recrystallization of confined soluble salts. Results suggest that wasteforms containing such high loadings of soluble salts may disintegrate if subjected to thermal cycling. Published by Elsevier Science B.V. RP Malone, PG (reprint author), USA,ENGINEER WATERWAYS EXPT STN,STRUCT LAB,CONCRETE TECHNOL DIV,VICKSBURG,MS 39180, USA. NR 9 TC 5 Z9 5 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD APR PY 1997 VL 52 IS 2-3 BP 237 EP 246 DI 10.1016/S0304-3894(96)01810-9 PG 10 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA XF549 UT WOS:A1997XF54900007 ER PT J AU Pincus, SH Messer, KG Cole, R Ireland, R VanCott, TC AF Pincus, SH Messer, KG Cole, R Ireland, R VanCott, TC TI Vaccine-specific antibody responses induced by HIV-1 envelope subunit vaccines SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; INFECTED LABORATORY WORKERS; GP160 RECOMBINANT VACCINIA; NEUTRALIZING ANTIBODIES; MONOCLONAL-ANTIBODIES; TYPE-1 GP120; SYNTHETIC PEPTIDE; IMMUNE-RESPONSE; NAIVE ADULTS; GLYCOPROTEIN AB The first generation of candidate vaccines to prevent HIV infection consisted of recombinant envelope proteins (Env, gp120, and gp160) derived from a single laboratory strain of HIV, designated IIIB/LAV, but produced with different expression systems. In this study we examined the fine specificity of the human Ab response to each vaccine and compared them to the responses of laboratory workers infected with the same strain of HIV. The best responders from each vaccine protocol were studied and compared. Detailed comparisons of the fine specificity of the Ab response were possible because all immunologic assays were performed using homologous recombinant proteins, peptides, and virus stocks. Although the total amounts of anti-Env Ab were comparable, the groups exhibited significant differences in epitope specificity, avidity, and functional capacity of the Ab response. The data demonstrate that the form of the immunogen (e.g., live virus or recombinant protein) is important in determining the quality of the Ab response. Conclusions are also drawn regarding characteristics of the anti-HIV-neutralizing Ab response. These studies represent one of the most detailed analyses of the human Ab response to any Ag and have implications for the development of vaccines for HIV as well as for other microbial pathogens. C1 PUBL HLTH RES INST,NEW YORK,NY 10016. WALTER REED ARMY INST RES,ROCKVILLE,MD 20850. NIAID,MICROBIAL STRUCT & FUNCT LAB,ROCKY MT LABS,HAMILTON,MT 59840. JOHNS HOPKINS UNIV,SCH PUBL HLTH,BALTIMORE,MD 21205. VANDERBILT UNIV,SCH MED,NASHVILLE,TN 37232. ST LOUIS UNIV,SCH MED,ST LOUIS,MO 63110. FU NIAID NIH HHS [N01AI05064, N01AI45211, R01AI23884] NR 46 TC 14 Z9 15 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 1 PY 1997 VL 158 IS 7 BP 3511 EP 3520 PG 10 WC Immunology SC Immunology GA WQ643 UT WOS:A1997WQ64300060 PM 9120313 ER PT J AU McClain, DJ Harrison, S Yeager, CL Cruz, J Ennis, FA Gibbs, P Wright, MS Summers, PL Arthur, JD Graham, JA AF McClain, DJ Harrison, S Yeager, CL Cruz, J Ennis, FA Gibbs, P Wright, MS Summers, PL Arthur, JD Graham, JA TI Immunologic responses to vaccinia vaccines administered by different parenteral routes SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID VIRUS; VACCINATION; PROTECTION; INHIBITION AB To develop a less reactogenic but equally immunogenic vaccine, this study of 91 human volunteers compared the safety and immunogenic potency of a new, cell culture-derived vaccinia virus vaccine administered intradermally and intramuscularly with the licensed vaccinia vaccine administered by scarification, Cutaneous pox lesions developed in a higher proportion of scarification vaccinees. Scarification and intradermal vaccine recipients who developed cutaneous pox lesions had more local reactions but also achieved significantly higher cell-mediated and neutralizing antibody responses than those who did not develop pox lesions, Although less reactogenic, intradermal or intramuscular administration of vaccinia vaccine without the concomitant development of a cutaneous pox lesion induced lower immune responses. C1 USA,MED RES INST INFECT DIS,DIV MED,FREDERICK,MD 21702. BROOKE ARMY MED CTR,SAN ANTONIO,TX. UNIV MASSACHUSETTS,SCH MED,DEPT MED,DIV INFECT DIS & IMMUNOL,WORCESTER,MA. RP McClain, DJ (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702, USA. NR 27 TC 51 Z9 51 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR PY 1997 VL 175 IS 4 BP 756 EP 763 DI 10.1086/513968 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA WQ022 UT WOS:A1997WQ02200003 PM 9086127 ER PT J AU Evans, JS Nims, T Cooley, J Bradley, W Jagodzinski, L Zhou, S Melcher, GP Burke, DS Vahey, M AF Evans, JS Nims, T Cooley, J Bradley, W Jagodzinski, L Zhou, S Melcher, GP Burke, DS Vahey, M TI Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HIV-INFECTION; ZIDOVUDINE THERAPY; VIRAL REPLICATION; PLASMA VIREMIA; MESSENGER-RNA; PROGRESSION; AIDS; SURVIVAL; QUANTIFICATION; GENDER AB The fundamental clinical, viral, and immunologic features of early-stage human immunodeficiency virus type 1 (HIV-1) disease were examined in a seroprevalent cohort of 28 men and 14 women assessed longitudinally at three equally dispersed time points over a mean of 43 months. There were no gender differences in the relative risk of developing AIDS-defining end points or death, The median serum RNA levels assessed at the three study time points were 3.3-, 4.9-, and 1.5-fold lower, respectively, in women than in men. This suggests that while serum virus load may be as powerful a correlate of disease status in women as it is in men, the absolute values of the virus levels may be different in the 2 populations, These observations may have implications for the interpretation of levels of virus burden in women for the assessment of disease progression, transmission, and treatment. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. WALTER REED ARMY INST RES,HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD. RP Evans, JS (reprint author), WILFORD HALL USAF MED CTR,DEPT INFECT DIS,2200 BERGQUIST DR,SUITE 1,LACKLAND AFB,TX 78236, USA. OI /0000-0002-5704-8094 NR 42 TC 48 Z9 48 U1 1 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR PY 1997 VL 175 IS 4 BP 795 EP 800 DI 10.1086/513973 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA WQ022 UT WOS:A1997WQ02200008 PM 9086132 ER PT J AU Rivas, F Diaz, LA Cardenas, VM Daza, E Bruzon, L Alcala, A DelaHoz, O Caceres, FM Aristizabal, G Martinez, JW Revelo, D DelaHoz, F Boshell, J Camacho, T Calderon, L Olano, VA Villarreal, LI Roselli, D Alvarez, G Ludwig, G Tsai, T AF Rivas, F Diaz, LA Cardenas, VM Daza, E Bruzon, L Alcala, A DelaHoz, O Caceres, FM Aristizabal, G Martinez, JW Revelo, D DelaHoz, F Boshell, J Camacho, T Calderon, L Olano, VA Villarreal, LI Roselli, D Alvarez, G Ludwig, G Tsai, T TI Epidemic Venezuelan equine encephalitis in La Guajira, Colombia, 1995 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article AB In 1995, the first Venezuelan equine encephalitis (VEE) outbreak in Colombia in 22 years caused an estimated 75,000 human cases, 3000 with neurologic complications and 300 fatal, in La Guajira State. Of the state's estimated 50,000 equines, 8% may have died. An epizootic IC virus, probably introduced from Venezuela, was rapidly amplified among unvaccinated equines. Record high rainfall, producing high densities of vector Aedes taeniorhynchus, led to extensive epidemic transmission (30% attack rate) in the four affected municipalities. Native Wayuu Indians, constituting 24% of the state's population, were at increased risk of infection (risk ratio, 3.3; 95% confidence interval, 2.2-5.3). Epidemiologic studies found no evidence of human-to-human transmission. A higher-than-expected number of abortions during the outbreak confirmed a previously suspected abortifacient role of VEE infection. Pesticide applications and a mass equine vaccination program contributed to preventing the outbreak's spread south of La Guajira. C1 CTR DIS CONTROL,DIV VECTOR BORNE INFECT DIS,FT COLLINS,CO 80522. COLOMBIAN FIELD EPIDEMIOL TRAINING PROGRAM,BOGOTA,COLOMBIA. HOSP SANTA CLARA,BOGOTA,COLOMBIA. NATL INST HLTH,DIV EPIDEMIOL,VIROL LAB,BOGOTA,COLOMBIA. NATL INST HLTH,ENTOMOL LAB,BOGOTA,COLOMBIA. MINIST HLTH,DIV RES & DEV,BOGOTA,COLOMBIA. MINIST HLTH,DIV DIRECT CAMPAIGNS,BOGOTA,COLOMBIA. HOSP RAMON GONZALEZ VALENCIA,EPIDEMIOL UNIT,BUCARAMANGA,COLOMBIA. DASALUD,HLTH SERV LA GUAJIRA,RIOHACHA,COLOMBIA. UNIV NORTE & LIBRE,EPIDEMIOL UNIT,BARRANQUILLA,COLOMBIA. HOSP SAN JORGE,EPIDEMIOL UNIT,PEREIRA,COLOMBIA. HLTH SERV PUTUMAYO,PUTAMAYO,COLOMBIA. CTR DIS CONTROL & PREVENT,INT BRANCH,EPIDEMIOL PROGRAM OFF,ATLANTA,GA. USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21701. OI Martinez, Jose William/0000-0003-3515-8572; Rosselli, Diego/0000-0003-0960-9480 NR 20 TC 109 Z9 115 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR PY 1997 VL 175 IS 4 BP 828 EP 832 DI 10.1086/513978 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA WQ022 UT WOS:A1997WQ02200013 PM 9086137 ER PT J AU Church, LWP Le, TP Bryan, JP Gordon, DM Edelman, R Fries, L Davis, JR Herrington, DA Clyde, DF Shmuklarsky, MJ Schneider, I McGovern, TW Chulay, JD Ballou, WR Hoffman, SL AF Church, LWP Le, TP Bryan, JP Gordon, DM Edelman, R Fries, L Davis, JR Herrington, DA Clyde, DF Shmuklarsky, MJ Schneider, I McGovern, TW Chulay, JD Ballou, WR Hoffman, SL TI Clinical manifestations of Plasmodium falciparum malaria experimentally induced by mosquito challenge SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID SPOROZOITE VACCINE; EFFICACY; SAFETY; IMMUNOGENICITY; VOLUNTEERS; PARASITEMIA; THERAPY; HUMANS AB To determine the characteristics of clinical illness accompanying Plasmodium falciparum infection induced by controlled exposure to infected mosquitoes, records of 118 volunteers participating in studies conducted between 1985 and 1992 were reviewed. One hundred fourteen volunteers (97%) reported at least one symptom attributable to malaria, with fatigue, myalgias or arthralgias, headache, and chills most commonly reported. The median duration of symptoms was 3 days. Fever was recorded in 61% of volunteers; 4 volunteers had temperatures >40 degrees C. Neutropenia and thrombocytopenia were present in 9% and 12% of volunteers, respectively. Despite counts as low as 658/mu L (neutrophils) or 73,000/mu L (platelets), no secondary infectious or hemorrhagic complications occurred. In all cases, volunteers recovered completely and laboratory values returned to baseline after specific antimalarial therapy. Recrudescence did not occur in any volunteer. In this model, mosquito inoculation of P. falciparum is a reliable, safe, and well-tolerated method of experimental challenge. C1 NATL NAVAL MED CTR, MALARIA PROGRAM, ROCKVILLE, MD 20852 USA. UNIFORMED SERV UNIV HLTH SCI, DEPT PREVENT MED & BIOMETR, BETHESDA, MD 20814 USA. USA, MED RES INST INFECT DIS, FT DETRICK, MD 21702 USA. UNIV MARYLAND, CTR VACCINE DEV, BALTIMORE, MD 21201 USA. JOHNS HOPKINS UNIV, CTR IMMUNIZAT RES, BALTIMORE, MD USA. WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DIV COMMUNICABLE DIS, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DIV EXPT THERAPEUT, WASHINGTON, DC 20307 USA. NR 36 TC 73 Z9 73 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR PY 1997 VL 175 IS 4 BP 915 EP 920 DI 10.1086/513990 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA WQ022 UT WOS:A1997WQ02200025 PM 9086149 ER PT J AU Doughty, RA AF Doughty, RA TI Anglo-French relations and strategy on the Western front, 1914-1918 - Philpott,WJ SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP Doughty, RA (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 2 Z9 2 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 1997 VL 61 IS 2 BP 389 EP 390 DI 10.2307/2953998 PG 2 WC History SC History GA WT185 UT WOS:A1997WT18500036 ER PT J AU Hunt, RA AF Hunt, RA TI Winning hearts and minds: British governments, the media and colonial counterinsurgency, 1944-1960 - Carruthers,SL SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP Hunt, RA (reprint author), US ARMY CTR MILITARY HIST,WASHINGTON,DC, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 1997 VL 61 IS 2 BP 410 EP 411 DI 10.2307/2954015 PG 2 WC History SC History GA WT185 UT WOS:A1997WT18500056 ER PT J AU Drea, EJ AF Drea, EJ TI An exhibit denied: Lobbying the history of the Enola-Gay - Harwit,M SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP Drea, EJ (reprint author), US ARMY CTR MILITARY HIST,WASHINGTON,DC, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 1997 VL 61 IS 2 BP 419 EP 421 DI 10.2307/2954023 PG 3 WC History SC History GA WT185 UT WOS:A1997WT18500064 ER PT J AU Breault, LG Billman, MA Lewis, DM AF Breault, LG Billman, MA Lewis, DM TI Report of a gingival ''surgical cyst'' developing secondarily to a subepithelial connective tissue graft SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE connective tissue, surgery,; grafts, gingival; gingival cysts, etiology ID COVERAGE AB THE SUBEPITHELIAL CONNECTIVE TISSUE GRAFT is a valuable technique used to cover exposed root surfaces or to increase the zone of attached gingiva. Cysts, such as the gingival cyst of the adult, an epithelial-lined cysts which may arise from heterotropic glandular tissue, a proliferating rete peg, remnants of the dental lamina, or traumatic implantation of epithelial tissue. In this paper, a case report is described of a ''surgical cyst'' or cystic morphogenesis of surgically implanted epithelium developing secondarily to a subepithelial connective tissue graft. C1 USA DENT ACT,PERIODONT RESIDENCY TRAINING PROGRAM,FT GORDON,GA. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. 163RD MED BATTALION,YONGSAN,SOUTH KOREA. NR 9 TC 18 Z9 19 U1 0 U2 1 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD APR PY 1997 VL 68 IS 4 BP 392 EP 395 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA WX669 UT WOS:A1997WX66900012 PM 9150046 ER PT J AU Manganaro, AM Bryant, AW AF Manganaro, AM Bryant, AW TI Speech aid prosthesis for a patient with Wegener's granulomatosis: A clinical report SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID MANIFESTATIONS C1 DEPT ORAL & MAXILLOFACIAL SURG,FT SAM HOUSTON,TX. DEPT PATHOL ANAT,FT SAM HOUSTON,TX. USA,DENT CORP,PROSTHODONT RESIDENCY PROGRAM,FT SAM HOUSTON,TX. NR 15 TC 2 Z9 2 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1997 VL 77 IS 4 BP 346 EP 347 DI 10.1016/S0022-3913(97)70156-2 PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA WT442 UT WOS:A1997WT44200002 PM 9104708 ER PT J AU Gronet, PM Driscoll, CF Hondrum, SO AF Gronet, PM Driscoll, CF Hondrum, SO TI Resiliency of surface-sealed temporary soft denture liners SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID LONGEVITY AB Statement of problem. Studies have suggested that coating a temporary soft denture liner with a semiset methyl methacrylate resin extends the period of resiliency of the liner. Purpose. This study determined whether coating three temporary soft denture liners with two different denture surface sealants, followed by thermocycling, affected the resiliency of the liners. Material and methods. Thirty 20 x 12.5 mm cylindrical samples each of Lynal, Coe Soft, and Visco-Gel soft lining materials were prepared and divided into three groups of 10 uncoated samples, 10 Palaseal-coated samples, and 10 mono-poly coated samples. Samples were thermocycled from 5 degrees C to 45 degrees C for 500 cycles and then compressed 10 mm on an Instron universal testing machine. Resiliency was determined by measuring the energy absorbed by the soft liners when stressed to a specific yield point. Results. Two-way ANOVA indicated a significant difference among materials (P = 0.0001) and among treatments (p = 0.0001). One-way ANOVA of each material group revealed a significant difference among Lynal groups (P = 0.0001) and a significant difference among Visco-Gel groups (P = 0.030). Conclusions. Surface-coating Lynal samples with Palaseal or mono-poly and Visco-Gel samples with Palaseal significantly increased the resiliency of these samples in the laboratory when compared with uncoated samples. C1 USA,DENT ACTIV,WALTER REED ARMY MED CTR,WASHINGTON,DC 20310. NR 15 TC 15 Z9 17 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1997 VL 77 IS 4 BP 370 EP 374 DI 10.1016/S0022-3913(97)70161-6 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA WT442 UT WOS:A1997WT44200007 PM 9104713 ER PT J AU Jackson, KE AF Jackson, KE TI Analytical crash simulation of three composite fuselage concepts and experimental correlation SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article; Proceedings Paper CT 52nd Annual Forum of the American-Helicopter-Society CY JUN 04-06, 1996 CL WASHINGTON, DC SP Amer Helicopter Soc AB The DYnamic Crash Analysis of STructures (DYCAST) crash analysis code was used to simulate the vertical impact response of two fuselage sections of the all-composite Lear Fan 2100 General Aviation aircraft. One fuselage section was tested in the unmodified condition, with the existing rigid subfloor in place. The second fuselage section was modified by replacing the rigid subfloor with an energy absorbing subfloor The DYCAST analysis results for both the unmodified and modified Lear Fan fuselage sections agreed well with the experimental data. The DYCAST analyses predicted the type and location of damage to the sections using a simple ultimate strain failure model. Experimental results from the Lear Fan testing program were used in the development of DYCAST models of three fuselage design concepts. The first fuselage concept is typical of conventional design and consists of a composite frame-reinforced fuselage shell with a stiff subfloor. The second fuselage concept is a retrofit of the previous design in which the rigid subfloor is replaced with a composite energy absorbing subfloor, The third fuselage concept is are innovative design which features a stiff ''inner'' fuselage intended to provide a protective shell surrounding the occupants, with a frangible ''outer'' shell which encapsulates an energy absorbing subfloor. The DYCAST models of the three fuselage concepts were analyzed for the same impact and loading conditions. A comparison of the response of the simulated occupant indicates a 25% reduction in vertical acceleration for the retrofit fuselage concept and a 50% reduction in vertical acceleration for the innovative third fuselage concept when compared with the conventional fuselage concept. RP Jackson, KE (reprint author), USA,NASA,LANGLEY RES CTR,ARL,VEHICLE STRUCT DIRECTORATE,HAMPTON,VA 23681, USA. NR 16 TC 8 Z9 10 U1 0 U2 1 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 1997 VL 42 IS 2 BP 116 EP 125 PG 10 WC Engineering, Aerospace SC Engineering GA WX680 UT WOS:A1997WX68000002 ER PT J AU Popelka, D Lindsay, D Parham, T Berry, V Baker, DJ AF Popelka, D Lindsay, D Parham, T Berry, V Baker, DJ TI Results of an aeroelastic tailoring study for a composite tiltrotor wing SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB The feasibility of a composite tailored wing for a high-speed civil tiltrotor is addressed using existing analytical methods. Composite tailoring is utilized to increase the proprotor aeroelastic stability margins for a thin wing (18% t/c) designed to improve high speed performance and productivity, Structural tailoring concepts are applied to the wing alone to improve the stability of the symmetric wing beamwise bending mode and the symmetric wing chordwise bending mode, which are the two most critical modes of instability. Skin laminate tailoring is shown to favorably influence the wing pitch/bending coupling and improve the stability of the wing beamwise mode. The wing chordwise mode stability is reduced by skin laminate tailoring due to a decrease in wing stiffness, but by tailoring the distribution of stringer and spar cap areas, the wing chard mode stability can be recovered, parametric studies show that the overall stability gains from composite tailoring can be limited because of conflicting structural design requirements imposed by the two critical modes of instability, and the necessity to balance the stability boundaries for bath modes. The parametric studies are used to define an 18% t/c tailored wing configuration that meets the stability goals with a minimum weight penalty. C1 USA,LANGLEY RES CTR,RES LAB,VEHICLE STRUCT DIRECTORATE,HAMPTON,VA. RP Popelka, D (reprint author), BELL HELICOPTER TEXTRON INC,FT WORTH,TX 76101, USA. NR 10 TC 6 Z9 6 U1 2 U2 2 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 1997 VL 42 IS 2 BP 126 EP 136 PG 11 WC Engineering, Aerospace SC Engineering GA WX680 UT WOS:A1997WX68000003 ER PT J AU Watson, CC Abt, SR Derrick, D AF Watson, CC Abt, SR Derrick, D TI Willow posts bank stabilization SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE biotechnical bank stabilization; willow posts; streambank protection ID VEGETATION AB Harland Creek, in east-central Mississippi, is a rapidly migrating, meandering stream that is experiencing severe bank erosion. More than 9,000 willow (Salix nigra) posts were emplaced in February 1994 by the U.S. Army, Corps of Engineers in an effort to stabilize eroding stream banks using an experimental bioengineering technique. Monitoring of this stream reach and the willow post bank stabilization has resulted in a data base to assess willow mortality as related to bank aspect, post diameter, cover, and base elevation above low water. Monitoring has also resulted in the development of revised construction guidelines. Survivability of the posts, a necessary condition for long-term success, was found to average 81 percent in May 1994, 43 percent in October 1994, and 41 percent in August 1995. Even with survivability as low as 29 percent to 34 percent at specific bend reaches, willow posts are documented to be successful in bank stabilization for the period of monitoring, in comparison with more traditional riprap stabilization methods. Guidelines for improved survivability and recommended site selection are presented. Cost of willow post bank stabilization is less than traditional riprap, and willow posts can be emplaced using readily available equipment and materials. C1 USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP Watson, CC (reprint author), COLORADO STATE UNIV,ENGN RES CTR,HYDROL LAB,FT COLLINS,CO 80523, USA. NR 22 TC 26 Z9 27 U1 0 U2 3 PU AMER WATER RESOURCES ASSOC PI HERNDON PA 950 HERNDON PARKWAY SUITE 300, HERNDON, VA 20170-5531 SN 0043-1370 J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD APR PY 1997 VL 33 IS 2 BP 293 EP 300 DI 10.1111/j.1752-1688.1997.tb03510.x PG 8 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA WX811 UT WOS:A1997WX81100007 ER PT J AU Kolka, MA Stephenson, LA AF Kolka, MA Stephenson, LA TI Interaction of menstrual cycle phase, clothing resistance and exercise on thermoregulation in women SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE thermoregulation; women; clothing; heat stress; sweating rate ID BLOOD-FLOW; RESPONSES; NIGHT; HEAT AB The purpose of this study was to describe core and skin temperatures and sweating rate in women during exercise when wearing clothing with high thermal resistance (R-T, 0.4 m(2).K-1.W-1). Exercise time was 60 +/- 12 min in early follicular experiments, 57 +/- 13 in late follicular experiments and 55 +/- 12 in mid-luteal experiments (NS). The end exercise mean body temperature was 38.19 +/- 0.24 degrees C, 37.86 +/- 0.472 degrees C and 38.36 +/- 0.33 degrees C, respectively (p < 0.05). Exercise tolerance under the conditions of these experiments was not different during the menstrual cycle phases studied. Published by Elsevier Science Ltd. RP Kolka, MA (reprint author), USA,ENVIRONM MED RES INST,THERMAL & MT MED DIV,NATICK,MA 01760, USA. NR 13 TC 10 Z9 10 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD APR PY 1997 VL 22 IS 2 BP 137 EP 141 DI 10.1016/S0306-4565(97)00003-X PG 5 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA XG243 UT WOS:A1997XG24300006 ER PT J AU Nusca, MJ AF Nusca, MJ TI Electromagnetic attenuation in plasmas generated by atmospheric flight SO JOURNAL OF THERMOPHYSICS AND HEAT TRANSFER LA English DT Article RP Nusca, MJ (reprint author), USA,RES LAB,WEAPONS & MAT RES DIRECTORATE,AMSRL WM PA,ABERDEEN PROVING GROUND,MD 21005, USA. NR 13 TC 1 Z9 1 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0887-8722 J9 J THERMOPHYS HEAT TR JI J. Thermophys. Heat Transf. PD APR-JUN PY 1997 VL 11 IS 2 BP 304 EP 306 DI 10.2514/2.6238 PG 3 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA WU625 UT WOS:A1997WU62500025 ER PT J AU Heffernan, JP Heidenberg, HB Irby, PB Moul, JW AF Heffernan, JP Heidenberg, HB Irby, PB Moul, JW TI Gossypiboma (retained surgical sponge) and recurrent bladder neck contracture after radical retropubic prostatectomy and bilateral pelvic lymph node dissection SO JOURNAL OF UROLOGY LA English DT Article DE bladder; prostate; iatrogenic disease; surgical sponges; bladder neck obstruction C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. USN HOSP,DEPT UROL,GROTON,CT. WALTER REED ARMY MED CTR,DEPT SURG,SERV UROL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,CTR PROSTATE DIS RES,BETHESDA,MD 20814. NR 3 TC 4 Z9 4 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD APR PY 1997 VL 157 IS 4 BP 1356 EP 1357 DI 10.1016/S0022-5347(01)64978-4 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA WN129 UT WOS:A1997WN12900057 PM 9120944 ER PT J AU Salminen, MO Carr, JK Robertson, DL Hegerich, P Gotte, D Koch, C SandersBuell, E Gao, F Sharp, PM Hahn, BH Burke, DS McCutchan, FE AF Salminen, MO Carr, JK Robertson, DL Hegerich, P Gotte, D Koch, C SandersBuell, E Gao, F Sharp, PM Hahn, BH Burke, DS McCutchan, FE TI Evolution and probable transmission of intersubtype recombinant human immunodeficiency virus type 1 in a Zambian couple SO JOURNAL OF VIROLOGY LA English DT Article ID RETROVIRAL RECOMBINATION; REVERSE TRANSCRIPTION; PHYLOGENETIC ANALYSIS; MAXIMUM-LIKELIHOOD; DNA-SEQUENCES; HIV TYPE-1; IDENTIFICATION; SUBTYPE; GENES; DIVERSITY AB The extraordinary genetic diversity of human immunodeficiency virus type 1 (HIV-1) results from the introduction of mutations by an error-prone reverse transcriptase and from recombination of the two RNA genomes packaged in the virion during the synthesis of proviral DNA. The occurrence of multiple, genetically distant HIV-1 subtypes and their geographic intermixing set up conditions for dramatic, rather than gradual, changes in genotype whenever genomes from different subtypes are copackaged in virions. Here we describe, for the first time, the sequential generation of multiple different, but related, intersubtype HIV-1 recombinants within an infected individual. Full-length gag and env genes were recovered directly from peripheral blood mononuclear cells or from primary virus cultures, using serial blood samples from a Zambian woman and a sample from her spouse. DNA sequencing and phylogenetic analysis established that two different A/C recombinant forms of HIV-1 predominated at two time points in the woman. A related but distinct recombinant HIV-1 was recovered from her spouse. Intersubtype recombination apparently played a central role in the evolution of HIV-1 in this couple and may contribute substantially to the rapid emergence of HIV-1 variants whenever mixed-subtype HIV-1 infections occur. C1 WALTER REED ARMY INST RES,HENRY M JACKSON FDN,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. UNIV NOTTINGHAM,QUEENS MED CTR,DEPT GENET,NOTTINGHAM NG7 2UH,ENGLAND. UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294. UNIV ALABAMA,DEPT MICROBIOL,BIRMINGHAM,AL 35294. RI Sharp, Paul/F-5783-2010; Salminen, Mika/D-8784-2013; OI Sharp, Paul/0000-0001-9771-543X; Salminen, Mika/0000-0003-3020-0866; /0000-0002-5704-8094 FU NIAID NIH HHS [N01 AI35170, R01AI25291] NR 50 TC 93 Z9 94 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD APR PY 1997 VL 71 IS 4 BP 2647 EP 2655 PG 9 WC Virology SC Virology GA WM911 UT WOS:A1997WM91100009 PM 9060617 ER PT J AU Olsen, GH Turell, MJ Pagac, BB AF Olsen, GH Turell, MJ Pagac, BB TI Efficacy of eastern equine encephalitis immunization in whooping cranes SO JOURNAL OF WILDLIFE DISEASES LA English DT Article DE eastern equine encephalitis virus; Grus americana; Grus canadensis; whooping cranes; sandhill cranes; vaccine ID ENCEPHALOMYELITIS VIRUS AB An epizootic of eastern equine encephalitis (EEE) at the Patuxent Wildlife Research Center (PWRC), Laurel, Maryland (USA), in 1989 provided an opportunity to determine if EEE immunization protected whooping cranes (Grus americana). Based on seroconversion of 31% of sympatric hatch-year sandhill cranes, Grus canadensis, and a previous 35% case fatality rate in whooping cranes, 17 (37%) of the 46 susceptible whooping cranes should have been exposed to virus and six should have died. As there were no deaths in these birds, the EEE vaccination program appeared to be efficacious in this whooping crane population. C1 USA,MED RES INST INFECT DIS,DIAGNOST SYST DIV,FT DETRICK,MD 21702. USA,ENTOMOL SCI DIV,FT GEORGE G MEADE,MD 20735. RP Olsen, GH (reprint author), US FISH & WILDLIFE SERV,PATUXENT WILDLIFE RES CTR,LAUREL,MD 20708, USA. NR 12 TC 18 Z9 18 U1 3 U2 4 PU WILDLIFE DISEASE ASSN, INC PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 SN 0090-3558 J9 J WILDLIFE DIS JI J. Wildl. Dis. PD APR PY 1997 VL 33 IS 2 BP 312 EP 315 PG 4 WC Veterinary Sciences SC Veterinary Sciences GA WW770 UT WOS:A1997WW77000020 PM 9131565 ER PT J AU Richmond, JY Ruble, DL Brown, B Jaax, GP AF Richmond, JY Ruble, DL Brown, B Jaax, GP TI Working safely at animal biosafety levels 3 and 4: Facility design implications SO LAB ANIMAL LA English DT Article AB Relatively few!laboratories in the world manage viral, bacterial, and toxic diseases with exotic and unfamiliar names like Congo Crimean Hemorrhagic Fever and Ebola Fever. The authors describe these laboratories and the operating procedures that take biomedical research into fascinating and somewhat foreboding realms of high-hazard biocontainment. C1 CDC,ANIM RESOURCES BRANCH,ATLANTA,GA 30333. USA,MED RES INST INFECT DIS,FREDERICK,MD. RP Richmond, JY (reprint author), CTR DIS CONTROL & PREVENT,OFF HLTH & SAFETY,1600 CLIFTON RD,FO5,ATLANTA,GA 30333, USA. NR 5 TC 3 Z9 3 U1 0 U2 0 PU NATURE PUBLISHING CO PI NEW YORK PA 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 SN 0093-7355 J9 LAB ANIMAL JI Lab Anim. PD APR PY 1997 VL 26 IS 4 BP 28 EP & PG 9 WC Veterinary Sciences SC Veterinary Sciences GA WR957 UT WOS:A1997WR95700005 ER PT J AU Burgess, EB AF Burgess, EB TI Marauders - Green,T SO LIBRARY JOURNAL LA English DT Book Review RP Burgess, EB (reprint author), USA,COMBINED ARMS RES LIB,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 1997 VL 122 IS 6 BP 125 EP 125 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA WP925 UT WOS:A1997WP92500244 ER PT J AU Dramiga, SA Rubal, BJ AF Dramiga, SA Rubal, BJ TI Rehabilitation following redo revascularization and repaired sternotomy SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE exercise; exercise therapy; coronary artery bypass complications; sternal dehiscence; mediastinitis AB DRAMIGA, S. A. and B. J. RUBAL. Rehabilitation following redo revascularization and repaired sternotomy. Med. Sci. Sports Exerc., Vol. 29, No. 4, pp. 427-329, 1997. Currently there are no guidelines for exercise prescription for cardiac patients with repaired sternotomy. This study reports good results in a 63-yr-old patient with prolonged course of hospitalization following mediastinitis and discusses considerations required for safe participation in competitive sports. RP Dramiga, SA (reprint author), BROOKE ARMY MED CTR,MCHE,MCD,SERV CARDIOL,3851 ROGER BROOKE DR,BLDG 3600,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 1 Z9 1 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD APR PY 1997 VL 29 IS 4 BP 427 EP 429 DI 10.1097/00005768-199704000-00001 PG 3 WC Sport Sciences SC Sport Sciences GA WU062 UT WOS:A1997WU06200001 PM 9107622 ER PT J AU Peacock, MD Morris, MJ Houghland, MA Anders, GT Blanton, HM AF Peacock, MD Morris, MJ Houghland, MA Anders, GT Blanton, HM TI Sleep apnea-hypopnea syndrome in a sample of veterans of the Persian Gulf War SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT US-Army-Regional-American-College-of-Physicians Meeting CY OCT 19-22, 1995 CL RESTON, VA SP US Army Reg Amer Coll Phys AB The prevalence of sleep apnea-hypopnea syndrome (SAHS) was investigated in a selected group of veterans of the Persian Gulf War at Brooke Army Medical Center, One hundred ninety-two self-referred patients participated in the full evaluation of the Comprehensive Clinical Evaluation Program (CCEP) for veterans of the Persian Gulf War, After completing an initial survey, an interview and examination were performed by staff internists. Forty-six participants with histories suggestive of a sleep disorder were referred for further evaluation, Those patients suspected of SAHS then completed a sleep disorders questionnaire and underwent standard nocturnal polysomnography (PSG), SAHS was defined as a respiratory disturbance index greater than or equal to 15 in a symptomatic patient, Fifteen of 46 patients undergoing PSG at this institution met criteria for SAHS. The majority of these patients had symptoms of fatigue and memory loss, Overall, 16 of the 192 patients (8.3%) in the CCEP of our institution were diagnosed with SAHS. SAHS may play a significant role in the symptom complex presented by many veterans of the Persian Gulf War. C1 BROOKE ARMY MED CTR,DEPT MED,PULM DIS CRIT CARE SERV,FT SAM HOUSTON,TX 78234. NR 12 TC 7 Z9 9 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1997 VL 162 IS 4 BP 249 EP 251 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA WU281 UT WOS:A1997WU28100008 PM 9110548 ER PT J AU Tiwary, CM AF Tiwary, CM TI A survey of use of hormone/placenta-containing hair preparations by parents and/or children attending pediatric clinics SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 7th Annual National-Cooperative-Growth-Study-Investigators Meeting CY OCT 28-31, 1993 CL SCOTTSDALE, AZ SP Natl Cooperative Growth Study Investigators ID SECONDARY SEXUAL CHARACTERISTICS; BOGALUSA HEART; AGE; PUBERTY; GIRLS AB Objective: To survey the frequency of use of certain hair-treatment products containing hormones or placenta among different racial groups attending the pediatric clinics of military medical treatment facilities. Methods: Parents/caretakers attending pediatric clinics at four U.S. Army hospital clinics were requested to complete a questionnaire listing hormone/placenta-containing hair products. Results: Of the 521 respondents, 64% of African-Americans and 6.9% of whites used products containing hormone/placenta (p < 0.0001). Of those parents who used such products, 55.5% used them on their children, An additional 5.5% of children (from a restricted sample) went to a barber and might have been exposed to hormone/placenta-containing products. Analysis of four products showed the presence of estriol and/or estradiol, Conclusions: A majority of African-Americans but very few whites use hair products containing hormone/placenta, and more than half of those who use such hair products also used them on their children. We speculate that the use of these hair products on children may effect their sexual maturation. C1 BROOKE ARMY MED CTR,DEPT PEDIAT,FT SAM HOUSTON,TX 78234. NR 22 TC 12 Z9 12 U1 2 U2 5 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1997 VL 162 IS 4 BP 252 EP 256 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA WU281 UT WOS:A1997WU28100009 PM 9110549 ER PT J AU Metter, EJ Granville, RL Kussman, MJ AF Metter, EJ Granville, RL Kussman, MJ TI The effect of threshold amounts for reporting malpractice payments to the National Practitioner Data Bank: Analysis using the closed claims data base of the Office of the Assistant Secretary of Defense (Health Affairs) SO MILITARY MEDICINE LA English DT Article ID CARE; STANDARD AB The study determines the extent to which payment thresholds for reporting malpractice claims to the National Practitioner Data Bank identifies substandard health care delivery in the Department of Defense, Relevant data were available on 2,291 of 2,576 medical malpractice claims reported to the closed medical malpractice case data base of the Office of the Assistant Secretary of Defense (Health Affairs). Amount paid was analyzed as a diagnostic test using standard of care assessment from each military Surgeon General office as the criterion, Using different paid threshold amounts per claim as a positive test, the sensitivity of identifying substandard care declined from 0.69 for all paid cases to 0.41 for claims over $40,000. Specificity increased from 0.75 for all paid claims to 0.89 for claims over $40,000. Positive and negative predictive values and likelihood ratio were similar at all thresholds, Malpractice case payment was of limited value for identifying substandard medical practice, All paid claims missed about 30% of substandard care, and reported about 25% of acceptable medical practice. RP Metter, EJ (reprint author), WALTER REED ARMY MED CTR,ARMED FORCES INST PATHOL,DEPT LEGAL MED,WASHINGTON,DC 20306, USA. NR 10 TC 0 Z9 0 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1997 VL 162 IS 4 BP 257 EP 261 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA WU281 UT WOS:A1997WU28100010 PM 9110550 ER PT J AU Jerant, AF Epperly, TD AF Jerant, AF Epperly, TD TI Fundamentals of telemedicine SO MILITARY MEDICINE LA English DT Article ID TECHNOLOGY AB The Department of Defense has recently devoted significant resources to telemedicine projects. This effort has arisen due to dramatic, parallel developments in telecommunications and computer technology, health care delivery systems, and the military medical mission, Most military health care providers have heard of telemedicine, but few have personal experience with its use, and even fewer understand the technology and the variety of systems available. This review covers the basic principles of telemedicine and describes some of the currently available systems. In addition, the history of telemedicine is briefly reviewed. Finally, ongoing civilian and military projects are discussed. These projects will clearly demonstrate that telemedicine is not a ''technology awaiting an application.'' Rather, this powerful clinical tool, which has been successfully utilized in actual patient care for over 30 years, is now ready for widespread implementation in both fixed-facility and field settings. RP Jerant, AF (reprint author), EISENHOWER ARMY MED CTR,DEPT FAMILY & COMMUNITY MED,FT GORDON,GA 30905, USA. NR 14 TC 9 Z9 10 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1997 VL 162 IS 4 BP 304 EP 309 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA WU281 UT WOS:A1997WU28100021 PM 9110561 ER PT J AU Ibrahim, MS Esposito, JJ Jahrling, PB Lofts, RS AF Ibrahim, MS Esposito, JJ Jahrling, PB Lofts, RS TI The potential of 5' nuclease PCR for detecting a single-base polymorphism in Orthopoxvirus SO MOLECULAR AND CELLULAR PROBES LA English DT Article DE Orthopoxvirus; PCR primers; fluorogenic probe; 5' nuclease assay; haemagglutinin ID POLYMERASE CHAIN-REACTION; DIFFERENTIATION; SMALLPOX; GENOME AB A fluorogenic 5' nuclease PCR assay was evaluated for its abilily to specifically detect and differentiate DNA of two Orthopoxvirus species. A pair of consensus primers that target a DNA segment of the Orthopoxvirus haemagglutinin gene, and two oligonucleotide probes, each labelled with a different fluorescent reporter dye and the same quencher dye, were used in a single-tube assay. The assay is based on the 5'-->3' nuclease activity of AmpliTaq DNA polymerase that cleaves a fluorescein-labelled hybridized probe. Probe cleavage generates specific fluorescent signals whose intensity can be quantified by fluorometry. After evaluating the effects of various annealing temperatures and probe concentrations and normalizing the emission intensities of the reporter dyes, it was possible to detect and differentiate monkeypox and vaccinia virus DNAs on the basis of a single-base polymorphism. The sensitivity of the 5' nuclease PCR assay is comparable to the sensitivity of ethidium bromide-stained gels, but the assay provides higher specificity and virtually eliminates the need for laborious post-PCR processing. (C) 1997 Academic Press Limited. C1 CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,ATLANTA,GA 30333. RP Ibrahim, MS (reprint author), USA,MED RES INST INFECT DIS,DIAGNOST SYST DIV,FREDERICK,MD 21702, USA. NR 9 TC 44 Z9 48 U1 1 U2 2 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0890-8508 J9 MOL CELL PROBE JI Mol. Cell. Probes PD APR PY 1997 VL 11 IS 2 BP 143 EP 147 DI 10.1006/mcpr.1996.0093 PG 5 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology GA WX532 UT WOS:A1997WX53200008 PM 9160329 ER PT J AU Duarte, FJ Costela, A GarciaMoreno, I Sastre, R Ehrlich, JJ Taylor, TS AF Duarte, FJ Costela, A GarciaMoreno, I Sastre, R Ehrlich, JJ Taylor, TS TI Dispersive solid-state dye laser oscillators SO OPTICAL AND QUANTUM ELECTRONICS LA English DT Article AB Narrow-linewidth multiple-prism grating solid-state dye laser oscillators are analysed using ray transfer matrices. Attention is given to beam divergence measurements and the effect on them of thermal lensing, at the solid-state gain medium. It is found that although thermal lensing leads to an increment of beam divergence, it induces oscillation in the unstable resonator regime, thus contributing to the attainment of TEM00 beam profiles. In addition, narrow-linewidth emission in dispersive oscillators, incorporating rhodamine 6 G doped HEMA:MMA gain media, is reported for the first time. Laser efficiency is 4-5% at a laser linewidth less than or equal to 1.8 GHz for double-longitudinal-mode emission. Beam divergence is measured in the 2-2.3 mrad range, in good agreement with theory. C1 CSIC,INST QUIM FIS ROCASOLANO,E-28006 MADRID,SPAIN. CSIC,INST CIENCIA & TECNOL POLIMEROS,E-28006 MADRID,SPAIN. USA,MISSILE COMMAND,CTR RES DEV & ENGN,REDSTONE ARSENAL,AL 35898. RP Duarte, FJ (reprint author), EASTMAN KODAK CO,ROCHESTER,NY 14650, USA. RI Garcia-Moreno, Inmaculada/J-8939-2014; Costela, Angel/A-3171-2012 OI Garcia-Moreno, Inmaculada/0000-0002-8682-3715; Costela, Angel/0000-0001-9417-2062 NR 19 TC 32 Z9 34 U1 0 U2 2 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0306-8919 J9 OPT QUANT ELECTRON JI Opt. Quantum Electron. PD APR PY 1997 VL 29 IS 4 BP 461 EP 472 DI 10.1023/A:1018551432627 PG 12 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA WZ935 UT WOS:A1997WZ93500003 ER PT J AU Liening, DA Lundy, L Silberberg, B Finstuen, K AF Liening, DA Lundy, L Silberberg, B Finstuen, K TI A comparison of the biocompatibility of three absorbable hemostatic agents in the rat middle ear SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID GELATIN SPONGE; CHI-SQUARE; FREQUENCIES; MEMBRANE; TABLES AB Absorbable gelatin sponge (Gelfoam) has been used for many years in middle ear surgery. Although the sponge is generally well tolerated, fibrosis occasionally forms in the mesotympanum some studies indicated that the absorbable gelatin sponge may be responsible. Many of these studies lack statistical analysis. We prospectively studied three absorbable hemostatic agents in the middle ear of adult male Sprague-Dawley rats to determine which promotes fibrosis to the greatest degree: absorbable gelatin sponge (Gelfoam), absorbable gelatin sheet (Gelfilm), or absorbable collagen sheet (Instat). The materials were implanted in the middle ear through a post-auricular approach and the temporal bones were serially harvested at different time intervals so we could examine histologic changes. The nonimplanted ear served as surgical control. Examination of the specimens at 6, 8, and in weeks by light microscopy revealed that although absorbable gelatin film and collagen-absorbable hemostat are well tolerated in this animal model, absorbable gelatin sponge promoted the presence of fibrosis to a significantly greater degree, (p = 0.0344). We conclude that absorbable gelatin sponge promotes fibrosis more frequently than do collagen-absorbable hemostat and absorbable gelatin film in this animal model. C1 BROOKE ARMY MED CTR,DEPT OTOLARYNGOL HEAD & NECK SURG,FT SAM HOUSTON,TX 78234. MICHIGAN EAR INST,FARMINGTON HILLS,MI. PROVIDENCE HOSP,DEPT PATHOL,SOUTHFIELD,MI 48037. USA,MED DEPT CTR & SCH,CTR HLTH CARE EDUC,WASHINGTON,DC. NR 18 TC 32 Z9 32 U1 0 U2 3 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD APR PY 1997 VL 116 IS 4 BP 454 EP 457 DI 10.1016/S0194-5998(97)70294-8 PG 4 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA WV687 UT WOS:A1997WV68700007 PM 9141394 ER PT J AU Rosenberg, R AF Rosenberg, R TI Drug-resistant scrub typhus: Paradigm and paradox SO PARASITOLOGY TODAY LA English DT Editorial Material ID RICKETTSIA-TSUTSUGAMUSHI; LEPTOTROMBIDIUM-PALLIDUM; VERTICAL TRANSMISSION; ANTIBODIES RP Rosenberg, R (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 16 TC 49 Z9 50 U1 2 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0169-4758 J9 PARASITOL TODAY JI Parasitol. Today PD APR PY 1997 VL 13 IS 4 BP 131 EP 132 DI 10.1016/S0169-4758(97)01020-X PG 2 WC Parasitology SC Parasitology GA WN167 UT WOS:A1997WN16700003 PM 15275098 ER PT J AU Norris, DA Whang, K DavidBajar, K Bennion, SD AF Norris, DA Whang, K DavidBajar, K Bennion, SD TI The influence of ultraviolet light on immunological cytotoxicity in the skin SO PHOTOCHEMISTRY AND PHOTOBIOLOGY LA English DT Review ID CUTANEOUS LUPUS-ERYTHEMATOSUS; TUMOR-NECROSIS-FACTOR; CULTURED HUMAN KERATINOCYTES; CELL-MEDIATED CYTOTOXICITY; ADHESION MOLECULE-1 ICAM-1; RO/SSA ANTIGEN EXPRESSION; CIS-UROCANIC ACID; FACTOR-ALPHA; CONTACT HYPERSENSITIVITY; NUCLEAR ANTIGENS C1 DEPT VET AFFAIRS HOSP,DENVER,CO. SOON CHUN HYANG UNIV,DEPT DERMATOL,SEOUL,SOUTH KOREA. BROOKE ARMY MED CTR,DEPT DERMATOL,SAN ANTONIO,TX. FITZSIMONS ARMY MED CTR,DEPT DERMATOL,AURORA,CO 80045. FITZSIMONS ARMY MED CTR,DEPT CLIN INVEST,AURORA,CO 80045. RP Norris, DA (reprint author), UNIV COLORADO,SCH MED,DEPT DERMATOL,4200 E 9TH AVE,DENVER,CO 80262, USA. NR 117 TC 25 Z9 27 U1 0 U2 1 PU AMER SOC PHOTOBIOLOGY PI AUGUSTA PA BIOTECH PARK, 1021 15TH ST, SUITE 9, AUGUSTA, GA 30901-3158 SN 0031-8655 J9 PHOTOCHEM PHOTOBIOL JI Photochem. Photobiol. PD APR PY 1997 VL 65 IS 4 BP 636 EP 646 DI 10.1111/j.1751-1097.1997.tb01905.x PG 11 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA WV985 UT WOS:A1997WV98500010 PM 9114739 ER PT J AU Bose, D Candler, GV AF Bose, D Candler, GV TI Simulation of hypersonic flows using a detailed nitric oxide formation model SO PHYSICS OF FLUIDS LA English DT Article ID ULTRAVIOLET ROCKET EXPERIMENTS; SHOCK; RELAXATION AB In this paper the extensive quasiclassical trajectory (QCT) study recently concluded [J. Chem. Phys. 104, 2825 (1996)] is used to model the kinetics of the primary NO formation reaction, N-2+O-->NO+N, in hypersonic nonequilibrium flows. The QCT data are used to obtain expressions for the thermal rate constant, reactant energy removal, and product energy disposal rates of this reaction. The QCT results are coupled with the continuum conservation flow equations, and these equations are used to simulate the Bow-Shock UltraViolet2 (BSUV2) flow at altitudes between 75 to 87.5 km. It is found that the use of the Macheret and Rich [Chem. Phys. 174, 25 (1993)] vibration-dissociation coupling model along with the QCT rates gives improvements in the NO concentration predictions at altitudes between 80 and 85 km. Also, it is found that the vibrational and rotational temperatures of NO are much higher than that of the N-2 and O-2 in the gas, in accordance with the BSUV2 measurements. The amount of NO produced in the flow fields at 87.5 km and above is found to be strongly dependent on the free-stream density of atomic oxygen. (C) 1997 American Institute of Physics. RP Bose, D (reprint author), UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,DEPT AEROSP ENGN & MECH,110 UNION ST SE,MINNEAPOLIS,MN 55455, USA. NR 35 TC 8 Z9 8 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1070-6631 J9 PHYS FLUIDS JI Phys. Fluids PD APR PY 1997 VL 9 IS 4 BP 1171 EP 1181 DI 10.1063/1.869205 PG 11 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA WQ094 UT WOS:A1997WQ09400032 ER PT J AU Jorgenson, DS Mayer, MH Ellenbogen, RG Centeno, JA Johnson, FB Mullick, FG Manson, PN AF Jorgenson, DS Mayer, MH Ellenbogen, RG Centeno, JA Johnson, FB Mullick, FG Manson, PN TI Detection of titanium in human tissues after craniofacial surgery SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article; Proceedings Paper CT Implantable Materials in Facial Aesthetic and Reconstructive Surgery - Biocompatability and Clinical Application Meeting CY OCT 06, 1995 CL MONTREAL, CANADA ID DEPOSITION AB Generally, titanium fixation plates are not removed after osteosynthesis, because they have high biocompatability and high corrosion resistance characteristics. Experiments with laboratory animals, and limited studies of analyses of human tissues, have reported evidence of titanium release into local and distant tissues. This study summarizes our results of the analysis of soft tissues for titanium in four patients with titanium microfixation plates. Energy dispersive x-ray analysis, scanning electron microscopy, and electrothermal atomic absorption spectrophotometry were used to detect trace amounts of titanium in surrounding soft tissues. A single metal inclusion was detected by scanning electron microscopy and energy dispersive x-ray analysis in one patient, whereas, electrothermal atomic absorption spectrophotometry analyses revealed titanium present in three of four specimens in levels ranging from 7.92 to 31.8 mu g/gm of dry tissue. Results from this study revealed trace amounts of titanium in tissues surrounding craniofacial plates. At the atomic level, electrothermal atomic absorption spectrophotometry appears to be a sensitive tool to quantitatively detect ultra-trace amounts of metal in human tissue. C1 WALTER REED ARMY MED CTR,NEUROL SERV,WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,CTR ENVIRONM TOXICOL & PATHOL,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,CTR ADV PATHOL,DEPT ENVIRONM & TOXICOL PATHOL,WASHINGTON,DC 20306. OREGON HLTH SCI UNIV,DIV PLAST & RECONSTRUCT SURG,PORTLAND,OR 97201. JOHNS HOPKINS UNIV,SCH MED,DIV PLAST RECONSTRUCT & MAXILLOFACIAL SURG,BALTIMORE,MD. NR 12 TC 63 Z9 64 U1 0 U2 4 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD APR PY 1997 VL 99 IS 4 BP 976 EP 979 DI 10.1097/00006534-199704000-00006 PG 4 WC Surgery SC Surgery GA WM060 UT WOS:A1997WM06000006 PM 9091942 ER PT J AU Pina, JS Horan, MP AF Pina, JS Horan, MP TI Alpha(1)-antitrypsin deficiency and asthma - The continuing search for the relationship SO POSTGRADUATE MEDICINE LA English DT Article ID ALPHA-1-ANTITRYPSIN DEFICIENCY; CLINICAL-FEATURES; INHIBITOR; EMPHYSEMA; SMOKING; HISTORY; ADULTS AB Patients with alpha(1)-antitrypsin (AAT) deficiency, like those with asthma and chronic obstructive pulmonary disease, usually present with dyspnea, wheeze, and cough. The similarity in presentation and unfamiliarity among clinicians with AAT deficiency account for much of the delay in diagnosis. Normally, AAT inhibits serine proteases, which cause alveolar destruction, and alters the function of cells that release mediators of inflammation. Diagnostic findings suggesting deficiency include irreversible airflow obstruction, a decreased diffusing capacity of the lung for carbon monoxide, bibasilar bullous disease on chest films, and a low serum level of AAT. Asthma is usually diagnosed on the basis of clinical findings and response to inhaled beta agonists. The presence of inflammation is believed to be necessary for development of clinically significant asthma. Inflammation added to a deficiency of antiprotease inhibitor activity significantly worsens bronchial hyperreactivity. This is only one mechanism by which AAT deficiency may potentiate allergic and bronchospastic responses. The prevalence of bronchial asthma in patients with AAT deficiency is unknown. Studies by the National Institutes of Health regarding the natural history of AAT deficiency and its response to therapy are under way. Perhaps more will be discovered about the relationship between the disorder and bronchial asthma. C1 VALLEY INTERNAL MED,RENTON,WA. RP Pina, JS (reprint author), TRIPLER ARMY MED CTR,PULM & CRIT CARE SERV,HONOLULU,HI 96859, USA. NR 21 TC 6 Z9 6 U1 0 U2 2 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD APR PY 1997 VL 101 IS 4 BP 153 EP & PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA WU089 UT WOS:A1997WU08900016 PM 9126209 ER PT J AU Satava, RM Jones, SB AF Satava, RM Jones, SB TI Virtual environments for medical training and education SO PRESENCE-TELEOPERATORS AND VIRTUAL ENVIRONMENTS LA English DT Article AB There are a number of modalities for implementing Virtual Environments (VE) for medical training and simulation. Integrating them For a seamless transition from one to another presents the next challenge. The three applications of (1) individual anatomic education and training, (2) medical crisis planning and training, and (3) medical virtual prototyping have been integrated into a single program approach by the military for battlefield trauma care. With this model as a template, the power of VE for the many different aspects of medical education can be explored and exploited. C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, BETHESDA, MD USA. RP Satava, RM (reprint author), DSO, DARPA, 3701 N FAIRFAX DR, ARLINGTON, VA 22203 USA. NR 13 TC 25 Z9 25 U1 0 U2 2 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA SN 1054-7460 J9 PRESENCE-TELEOP VIRT JI Presence-Teleoper. Virtual Env. PD APR PY 1997 VL 6 IS 2 BP 139 EP 146 PG 8 WC Computer Science, Cybernetics; Computer Science, Software Engineering SC Computer Science GA WW655 UT WOS:A1997WW65500002 ER PT J AU Higgins, GA Merrill, GL Hettinger, LJ Kaufmann, CR Champion, HR Satava, RM AF Higgins, GA Merrill, GL Hettinger, LJ Kaufmann, CR Champion, HR Satava, RM TI New simulation technologies for surgical training and certification current status and future projections SO PRESENCE-TELEOPERATORS AND VIRTUAL ENVIRONMENTS LA English DT Article ID PERFORMANCE AB Computer-based virtual reality technology has evolved to the point at which medical simulation can be incorporated into medical education and into the eventual objective evaluation of surgical competence, Flight simulation provides a model for examining the role of computer-based simulation in medical training and certification. The plan by which medical simulators are being designed and validated for surgical training is presented, as is a description of the current slate of medical simulation and the limitations of the technology. A realistic argument for adoption is suggested that takes into account lower price constraints, technological limitations, and professional barriers to the implementation of simulator-based training and accreditation. C1 HIGH TECHSPLANAT INC, ROCKVILLE, MD 20852 USA. LOGICON TECH SERV, DAYTON, OH 45431 USA. UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. RP Higgins, GA (reprint author), IMAGE MED COMMUN, VIENNA, VA 22182 USA. NR 13 TC 17 Z9 17 U1 0 U2 2 PU M I T PRESS PI CAMBRIDGE PA FIVE CAMBRIDGE CENTER, CAMBRIDGE, MA 02142 SN 1054-7460 J9 PRESENCE-TELEOP VIRT JI Presence-Teleoper. Virtual Env. PD APR PY 1997 VL 6 IS 2 BP 160 EP 172 PG 13 WC Computer Science, Cybernetics; Computer Science, Software Engineering SC Computer Science GA WW655 UT WOS:A1997WW65500004 ER PT J AU Satava, RM Robb, RA AF Satava, RM Robb, RA TI Virtual endoscopy: Application of 3D visualization to medical diagnosis SO PRESENCE-TELEOPERATORS AND VIRTUAL ENVIRONMENTS LA English DT Article ID REALITY; DISPLAY; IMAGES AB Virtual endoscopy is a diagnostic technique in which a three-dimensional imaging technology (CT scan, MRI scan, ultrasound) is used to create a computer-generated representation of a specific patient's anatomy or organ, and then the virtual organ is "flown through," giving the same visual impression and image as if the corresponding real organ had a video or fiberoptic endoscopic procedure performed. The potential is to provide a computer diagnosis to replace an endoscopic procedure, not only for conventional endoscopy such as bronchoscopy, colonoscopy, sinusoscopy, or hysteroscopy, but also for areas where traditional endoscopy is not possible, such as the inner ear, spleen, lymphatic tissues. With sophisticated signal processing and computational analysis, it may be possible in the future to perform a "numerical biopsy," that is, make a tissue diagnosis based upon spectral or other information contained in the images. C1 DEF ADV RES PROJECTS AGCY, ARLINGTON, VA 22203 USA. RP Satava, RM (reprint author), WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NR 44 TC 16 Z9 16 U1 0 U2 0 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA SN 1054-7460 J9 PRESENCE-TELEOP VIRT JI Presence-Teleoper. Virtual Env. PD APR PY 1997 VL 6 IS 2 BP 179 EP 197 PG 19 WC Computer Science, Cybernetics; Computer Science, Software Engineering SC Computer Science GA WW655 UT WOS:A1997WW65500006 ER PT J AU Kirchner, RF Kondratieff, BC AF Kirchner, RF Kondratieff, BC TI A new species of Nearctic Perlesta (Plecoptera: Perlidae) from Virginia SO PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF WASHINGTON LA English DT Article DE Perlesta; new species; North America; Nearctic Region; Virginia AB A new species of stonefly from southwestern Virginia is added to the Nearctic Perlesta, which presently includes 14 species. Perlesta teaysia, new species, is described from the adult male, adult female, egg, and mature nymph. Diagnostic features are supported by illustrations and SEM photomicrographs. RP Kirchner, RF (reprint author), USA,HUNTINGTON DIST CORPS ENGINEERS,WATER QUAL SECT,502 8TH ST,HUNTINGTON,WV 25701, USA. NR 3 TC 9 Z9 10 U1 0 U2 0 PU ENTOMOL SOC WASHINGTON PI WASHINGTON PA SMITHSONIAN INSTITUTION DEPT ENTOMOLOGY, WASHINGTON, DC 20560 SN 0013-8797 J9 P ENTOMOL SOC WASH JI Proc. Entomol. Soc. Wash. PD APR PY 1997 VL 99 IS 2 BP 290 EP 293 PG 4 WC Entomology SC Entomology GA XC164 UT WOS:A1997XC16400007 ER PT J AU Sammons, MT Brown, AB AF Sammons, MT Brown, AB TI The department of defense psychopharmacology demonstration project: An evolving program for postdoctoral education in psychology SO PROFESSIONAL PSYCHOLOGY-RESEARCH AND PRACTICE LA English DT Article ID PRESCRIPTION PRIVILEGES AB In 1991, the Department of Defense (DoD) initiated a program designed to train doctoral-level psychologists to prescribe psychotropic medications. The program is housed in the psychology department at Waiter Reed Army Medical Center (WRAMC); trainees receive didactic instruction at the Uniformed Services University of the Health Sciences and clinical training through the departments of psychology and psychiatry at WRAMC and Malcolm Grow Air Force Medical Center. Since its inception, the training curriculum has evolved from a standard medical school, basic sciences sequence to a tailored program designed specifically to meet the goal of training psychologists to become proficient in the independent use of psychopharmacological agents. To date, the program and its curriculum have not been described in detail in the literature. This article provides an archival reference of the DoD program by means of a review of successive versions of the curriculum and a comparison of these versions to other published models for training psychologists to this end. C1 WALTER REED ARMY MED CTR, WASHINGTON, DC USA. RP Sammons, MT (reprint author), NATL NAVAL MED CTR, DEPT PSYCHOL, 8901 WISCONSIN AVE, BETHESDA, MD 20889 USA. NR 9 TC 21 Z9 21 U1 0 U2 1 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0735-7028 J9 PROF PSYCHOL-RES PR JI Prof. Psychol.-Res. Pract. PD APR PY 1997 VL 28 IS 2 BP 107 EP 112 DI 10.1037/0735-7028.28.2.107 PG 6 WC Psychology, Multidisciplinary SC Psychology GA WP322 UT WOS:A1997WP32200003 ER PT J AU James, LC Folen, RA Garland, FN Davis, MK AF James, LC Folen, RA Garland, FN Davis, MK TI A new frontier for clinical health psychologists: Our leadership role in the development and management of an inpatient weight management program SO PROFESSIONAL PSYCHOLOGY-RESEARCH AND PRACTICE LA English DT Article ID OBESITY TREATMENT PROGRAM; TERM FOLLOW-UP AB The article provides an overview of the Tripler Army Medical Center Inpatient Obesity Program. Termed the LEAN Program (emphasizing healthy Lifestyles, Exercise, Emotions, Attitudes and Nutrition), it is the first inpatient hospital program completely developed, administratively owned, and directed by Department of Defense psychologists. The major components of the program are discussed, as is the conceptual framework that underlies the development. The LEAN Program model is offered as a guide for those who wish to develop other programs in inpatient health psychology. C1 TRIPLER ARMY MED CTR,HLTH PSYCHOL SERV,HONOLULU,HI 96859. ARMY CTR HLTH PROMOT & PREVENT MED,ABERDEEN PROVING GROUND,MD. RP James, LC (reprint author), TRIPLER ARMY MED CTR,DEPT PSYCHOL,LEAN PROGRAM,HONOLULU,HI 96859, USA. NR 30 TC 9 Z9 9 U1 2 U2 4 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0735-7028 J9 PROF PSYCHOL-RES PR JI Prof. Psychol.-Res. Pract. PD APR PY 1997 VL 28 IS 2 BP 146 EP 152 DI 10.1037/0735-7028.28.2.146 PG 7 WC Psychology, Multidisciplinary SC Psychology GA WP322 UT WOS:A1997WP32200009 ER PT J AU Taylor, PJ Jesser, WA Rosi, FD Derzko, Z AF Taylor, PJ Jesser, WA Rosi, FD Derzko, Z TI A model for the non-steady-state temperature behaviour of thermoelectric cooling semiconductor devices SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article AB A simple, easily applied model describing the non-steady-state temperature behaviour of thermoelectric cooling semiconductor devices is derived from consideration of the heat flows arising from thermal conductivity, the Peltier effect and Joule heating in a typical thermoelectric cooling device. The derived model is tested by comparison with the measured performance of a thermoelectric cooling device constructed for this study. The model is shown to accurately predict device behaviour to a statistical confidence limit of 99% for the given device criteria and experimental conditions. C1 USA,CECOM,NIGHT VIS & ELECT SENSORS DIRECTORATE,FT BELVOIR,VA 22060. RP Taylor, PJ (reprint author), UNIV VIRGINIA,DEPT MAT SCI & ENGN,THORNTON HALL,CHARLOTTESVILLE,VA 22903, USA. NR 10 TC 12 Z9 13 U1 0 U2 3 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL, ENGLAND BS1 6BE SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD APR PY 1997 VL 12 IS 4 BP 443 EP 447 DI 10.1088/0268-1242/12/4/018 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA WV279 UT WOS:A1997WV27900017 ER PT J AU Cragg, GM Newman, DJ Weiss, RB AF Cragg, GM Newman, DJ Weiss, RB TI Coral reefs, forests, and thermal vents: The worldwide exploration of nature for novel antitumor agents SO SEMINARS IN ONCOLOGY LA English DT Article ID NATIONAL-CANCER-INSTITUTE; DRUG DISCOVERY; ANTICANCER; PRODUCTS; PLANTS C1 WALTER REED ARMY MED CTR,SECT MED ONCOL,WASHINGTON,DC 20307. RP Cragg, GM (reprint author), NCI,NAT PROD BRANCH,DEV THERAPEUT PROGRAM,DIV CANC TREATMENT DIAG & CTR,FREDERICK,MD 21702, USA. NR 23 TC 80 Z9 86 U1 1 U2 8 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0093-7754 J9 SEMIN ONCOL JI Semin. Oncol. PD APR PY 1997 VL 24 IS 2 BP 156 EP 163 PG 8 WC Oncology SC Oncology GA WV274 UT WOS:A1997WV27400003 PM 9129686 ER PT J AU Vartuli, CB Pearton, SJ Abernathy, CR MacKenzie, JD Lovejoy, ML Shul, RJ Zolper, JC Baca, AG HagerottCrawford, M Jones, A Ren, F AF Vartuli, CB Pearton, SJ Abernathy, CR MacKenzie, JD Lovejoy, ML Shul, RJ Zolper, JC Baca, AG HagerottCrawford, M Jones, A Ren, F TI Conduction mechanisms in W and WSix ohmic contacts to InGaN and InN SO SOLID-STATE ELECTRONICS LA English DT Article ID MOLECULAR-BEAM EPITAXY; LIGHT-EMITTING-DIODES; GAN; RESISTANCE; GROWTH AB The temperature dependence of the specific contact resistance of Wand WSi0.44 contacts On n(+) In0.65Ga0.35N and InN was measured in the range -50-125 degrees C. The results were compared to theoretical values for different conduction mechanisms, to further elucidate the conduction mechanism in these contact structures. The data indicates the conduction mechanism is field emission for these contact schemes for all but as-deposited metal to InN where thermionic emission appears to be the dominant mechanism. The contacts were found to produce low specific resistance ohmic contacts to InGaN at room temperature, rho(c) similar to 10(-7) Omega . cm(2) for W and rho(c) of 4 x 10(-7) Omega . cm(2) for WSix. InN metallized with W produced ohmic contacts with rho(c) similar to 10(-7) Omega . cm(2) and rho(c) similar to 10(-6) Omega . cm(2) for WSix at room temperature. (C) 1997 Elsevier Science Ltd. C1 SANDIA NATL LABS,ALBUQUERQUE,NM 87185. USA,RES LAB,FT MONMOUTH,NJ 07703. AT&T BELL LABS,LUCENT TECHNOL,MURRAY HILL,NJ 07974. RP Vartuli, CB (reprint author), UNIV FLORIDA,DEPT MAT SCI & ENGN,GAINESVILLE,FL 32611, USA. NR 18 TC 5 Z9 6 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD APR PY 1997 VL 41 IS 4 BP 531 EP 534 DI 10.1016/S0038-1101(96)00188-8 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA WT062 UT WOS:A1997WT06200004 ER PT J AU Armstrong, DG Lavery, LA Quebedeaux, TL Walker, SC AF Armstrong, DG Lavery, LA Quebedeaux, TL Walker, SC TI Surgical morbidity and the risk of amputation due to infected puncture wounds in diabetic versus nondiabetic adults SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID FOOT ULCERS; LEVEL; MALNUTRITION AB We reviewed the hospital course of 77 diabetic and 69 nondiabetic subjects who had incision, drainage, and exploration of infected puncture wounds of the foot. Diabetics were 5 times more likely to have multiple operations and 46 times more likely to have a lower extremity amputation than nondiabetics. The interval from injury to surgery was significantly longer in diabetics than nondiabetics. Total lymphocyte count and hemoglobin, hematocrit, and albumin values were significantly lower in diabetics than in nondiabetics. Diabetic amputees had higher prevalences of nonpalpable pulses, nephropathy, neuropathy, and osteomyelitis as compared with diabetic nonamputees. The neuropathic diabetic foot is not protected by pain. When combined with other comorbid factors, this may increase morbidity associated with puncture wounds of the foot. C1 BROOKE ARMY MED CTR,DEPT ANESTHESIOL & OPERAT SERV,SAN ANTONIO,TX. MEXICAN AMER MED TREATMENT EFFECTIVENESS RES CTR,SAN ANTONIO,TX. RP Armstrong, DG (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT ORTHOPAED,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. NR 29 TC 30 Z9 35 U1 1 U2 2 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD APR PY 1997 VL 90 IS 4 BP 384 EP 389 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA WU968 UT WOS:A1997WU96800004 PM 9114827 ER PT J AU Vories, AA Ramirez, SG AF Vories, AA Ramirez, SG TI Warthin's tumor and cigarette smoking SO SOUTHERN MEDICAL JOURNAL LA English DT Article; Proceedings Paper CT South Texas Chapter of the American College of Surgeons Meeting CY MAR 15-16, 1996 CL SAN ANTONIO, TX ID PAROTID-GLAND; ADENOLYMPHOMA; PREDOMINANCE; EXPERIENCE AB Warthin's tumor is a relatively uncommon salivary gland neoplasm, traditionally considered a disease of men. Recent reports have brought this assumption into question by identifying a substantial percentage of patients who are women. Furthermore, several reports have attempted to correlate cigarette smoking with development of Warthin's tumor. We retrospectively studied all cases of parotid tumor entered in the Brooke Army Medical Center Tumor Registry from 1973 to 1993. Relative percentages of benign and malignant disease, as well as frequency of individual tumor types, in general mirrored those in earlier reports. A high proportion of Warthin's tumor-23% of all tumors-was identified. More than one third of patients with Warthin's tumor were women. Also, 94% of patients with Warthin's tumor had a history of tobacco use; for all other tumor types combined, only 60% of patients had a history of tobacco use. This statistical difference supports the correlation between cigarette smoking and Warthin's tumor. RP Vories, AA (reprint author), BROOKE ARMY MED CTR,MCHE SDT,OTOLARYNGOL HEAD & NECK SURG SERV,BLDG 3600,3851 ROGER BROOKE DR,FT SAM HOUSTON,TX 78234, USA. NR 20 TC 19 Z9 19 U1 1 U2 1 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD APR PY 1997 VL 90 IS 4 BP 416 EP 418 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA WU968 UT WOS:A1997WU96800011 PM 9114834 ER PT J AU Lammi, ER AF Lammi, ER TI Training and performance: A system for success SO STRENGTH AND CONDITIONING LA English DT Article RP Lammi, ER (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 4 TC 1 Z9 1 U1 1 U2 1 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, CHAMPAIGN, IL 61820-2200 SN 1073-6840 J9 STRENGTH COND JI Strength Cond. PD APR PY 1997 VL 19 IS 2 BP 34 EP 37 DI 10.1519/1073-6840(1997)019<0034:TAPASF>2.3.CO;2 PG 4 WC Sport Sciences SC Sport Sciences GA WT901 UT WOS:A1997WT90100008 ER PT J AU Jackson, MR Krishnamurti, C Aylesworth, CA Alving, BM AF Jackson, MR Krishnamurti, C Aylesworth, CA Alving, BM TI Diagnosis of heparin-induced thrombocytopenia in the vascular surgery patient SO SURGERY LA English DT Article ID PLATELET-AGGREGATION TEST; CARDIOPULMONARY BYPASS; THROMBOSIS; FACTOR-4; ANTIBODIES; COMPLEXES; ORG-10172; ANTIGEN AB Background. Recent studies have shown that patients with heparin-induced thrombocytopenia (HIT) form immunoglobulin G (IgG) and/or IgM antibodies directed against a complex of platelet factor 4 (PF4) and heparin. This recognition has resulted in the development of enzyme-linked immunosorbent assays (ELISAs) that use the heparin/PF4 complex as the antigen. This study describes the use of a standardized ELISA to assess antibody formation in five patients suspected of having HIT. Methods. Five patients received heparin for treatment of arterial or venous thrombotic disorders. All patients had the ELISA performed to detect IgG or IgM antibodies directed against heparin-PF4, as well as the C-14 serotonin release assay, when HIT was clinically suspected. Results. HIT was diagnosed in four patients and ruled out in a fifth by using the ELISA. All patients had a 40% decrease in platelet count that returned to normal after heparin cessation. Only one of the four patients who tested positive by ELISA for IgG antibodies also tested positive by the C-14 serotonin release assay. Treatment wets significantly altered by the ELISA results in all five patients. Conclusions. It is likely that the ELISA is more sensitive in the diagnosis of HIT than the more traditional aggregation tests, and it may emerge as a new gold standard. Prospective studies in which serial laboratory testing is combined with measurement of clinical outcomes are needed and will eventually provide a greater understanding of the full spectrum of HIT and the clinical settings that precipitate thrombosis in the vascular surgery patient. C1 WALTER REED ARMY MED CTR,VASC SURG SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. RP Jackson, MR (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307, USA. NR 28 TC 15 Z9 15 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0039-6060 J9 SURGERY JI Surgery PD APR PY 1997 VL 121 IS 4 BP 419 EP 424 DI 10.1016/S0039-6060(97)90312-3 PG 6 WC Surgery SC Surgery GA WR793 UT WOS:A1997WR79300009 PM 9122872 ER PT J AU AlapeGiron, A MirandaArrieta, K CortesBratti, X Stiles, BG Gutierrez, JM AF AlapeGiron, A MirandaArrieta, K CortesBratti, X Stiles, BG Gutierrez, JM TI A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus SO TOXICON LA English DT Article ID FULVIUS-FULVIUS; ANTIVENOM; ASSAY; NEUTRALIZATION; NEUROTOXINS; ELISA AB Therapeutic antisera against Micrurus nigrocinctus venom were tested for protection against lethality, as well as for inhibition of the nicotinic acetylcholine receptor (AchR)-binding and neutralization of phospholipase A(2) (PLA(2)) activities of the homologous venom. Protection against venom lethality did not correlate with inhibition of AchR-binding activity, whereas there was a significant correlation between antisera potency and inhibition of PLA(2) activity (r = 0.82, n = 10, P < 0.02). Inhibition of PLA, activity could be useful in assessing the protective efficacy of M. nigrocinctus antisera during antivenom production. Micrurus nigrocinctus nigrocinctus venom proteins were fractionated by cation-exchange chromatography on Mono S FPLC and fractions assayed for lethality, AchR-binding and PLA(2) activities. Antisera were titrated by enzyme-linked immunoassay (ELISA) against a crude M. n. nigrocinctus venom, two FPLC lethal fractions containing AchR-binding activity, and two toxins purified from M. n. nigrocinctus venom. No correlation was found between protective efficacy and the ELISA titer against any of these antigens. Compared to other elapid venoms that contain few toxins as major components, M. n. nigrocinctus venom appears to be more complex and its lethal effect is likely to be due to the combined effect of several neurotoxins. (C) 1997 Elsevier Science Ltd. C1 UNIV COSTA RICA,FAC MICROBIOL,INST CLODOMIRO PICADO,SAN JOSE,COSTA RICA. UNIV COSTA RICA,FAC MED,DEPT BIOQUIM,SAN JOSE,COSTA RICA. USA,MED RES INST INFECT DIS,TOXINOL DIV,FREDERICK,MD 21701. RP AlapeGiron, A (reprint author), KAROLINSKA INST,CTR MICROBIOL & TUMOR BIOL,S-17177 STOCKHOLM,SWEDEN. OI Gutierrez, Jose Maria/0000-0001-8385-3081 NR 30 TC 12 Z9 13 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD APR PY 1997 VL 35 IS 4 BP 573 EP 581 DI 10.1016/S0041-0101(96)00150-X PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA WU152 UT WOS:A1997WU15200009 PM 9133712 ER PT J AU Schellhammer, P Cockett, A BocconGibod, L Gospodarowicz, M Krongrad, A Thompson, IM Scardino, P Soloway, M Adolfsson, J AF Schellhammer, P Cockett, A BocconGibod, L Gospodarowicz, M Krongrad, A Thompson, IM Scardino, P Soloway, M Adolfsson, J TI Assessment of endpoints for clinical trials for localized prostate cancer SO UROLOGY LA English DT Article ID DIGITAL RECTAL EXAMINATION; RADICAL RETROPUBIC PROSTATECTOMY; DEFINITIVE RADIATION-THERAPY; ULTRASOUND-GUIDED BIOPSY; TRANSRECTAL ULTRASOUND; NEEDLE-BIOPSY; ANTIGEN; RADIOTHERAPY; RECURRENCE; PATTERNS AB Objectives. The AUA Practice Guidelines Panel convened to address the issue of appropriate endpoints for assessment of treatment modalities for localized carcinoma of the prostate. Methods. A review of the literature and the design of existing clinical trials produced a consensus, which was presented to and critiqued by the members of the general conference. Results. The pitfalls associated with identification of local failure endpoints were discussed, and the more accurate endpoints of freedom from metastatic progression and overall survival were recognized. The strict definition that must be fulfilled for intermediate endpoints to become surrogates for metastasis free and/or survival endpoints was stressed. For more efficient and rapid conduct of future clinical trials, the urgent need to validate such surrogate endpoints by evaluation in randomized control trials is obvious. PSA, while an indicator of disease activity and a critical marker for estimating disease progression or regression in response to therapy, is not a surrogate for metastasis free or overall survival. Conclusion. Until surrogate endpoints are validated, the committee has evaluated the endpoints in current use, reviewed their limitations, and stressed the importance of quality-of-life assessment together with the traditional endpoint assessment. (C) 1997 by Elsevier Science Inc. C1 EASTERN VIRGINIA MED SCH, DEPT UROL, NORFOLK, VA 23501 USA. SENTARA CANC INST, CTR UROL ONCOL, NORFOLK, VA USA. UNIV ROCHESTER, SCH MED, DEPT UROL, ROCHESTER, NY USA. HOP BIRCHAT, DEPT UROL, PARIS, FRANCE. UNIV MIAMI, SCH MED, MIAMI, FL USA. PRINCESS MARGARET HOSP, ONTARIO CANC INST, TORONTO, ON, CANADA. VET AFFAIRS MED CTR, UROL SECT, MIAMI, FL 33125 USA. BROOKE ARMY MED CTR, UROL SERV, FT SAM HOUSTON, TX 78234 USA. BAYLOR COLL MED, SCOTT DEPT UROL, HOUSTON, TX 77030 USA. KAROLINSKA HOSP, DEPT UROL, S-10401 STOCKHOLM, SWEDEN. NR 78 TC 36 Z9 36 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 EI 1527-9995 J9 UROLOGY JI Urology PD APR PY 1997 VL 49 IS 4A SU S BP 27 EP 38 DI 10.1016/S0090-4295(99)80321-5 PG 12 WC Urology & Nephrology SC Urology & Nephrology GA WU208 UT WOS:A1997WU20800004 PM 9111612 ER PT J AU Altwein, J Ekman, P Barry, M Biermann, C Carlsson, P Fossa, S Kiebert, G Kuchler, T McLeod, D Porter, A Steineck, G AF Altwein, J Ekman, P Barry, M Biermann, C Carlsson, P Fossa, S Kiebert, G Kuchler, T McLeod, D Porter, A Steineck, G TI How is quality of life in prostate cancer patients influenced by modern treatment? The Wallenberg Symposium SO UROLOGY LA English DT Article ID RADICAL RETROPUBIC PROSTATECTOMY; OF-LIFE; URINARY CONTINENCE; HORMONAL-THERAPY; MANAGEMENT; CARCINOMA; PRESERVATION; RADIOTHERAPY; POPULATION; EXPERIENCE AB Objectives. To identify complications of various forms of treatments for prostate cancer and their influence on patients' quality of life with the ultimate goal of suggesting a Quality of Life Questionnaire specific for prostate cancer for further validation. Methods. The literature was screened for reports on the more common complications following various forms of therapy for prostate cancer. Frequencies were summarized. The scarce literature reporting on quality of life in prostate cancer was reviewed and conflicting data were discussed and reassessed. Suggested questionnaires used in other studies were critically scrutinized and the various questions recorded. Results. Following radical surgery, impotence and incontinence were the most common complications reducing patients' quality of life. The literature was not uniform with regard to whether loss of sexual function was regarded as a worse complication than loss of urinary control. Following radiotherapy, intestinal problems and sexual dysfunction were the dominating side-effects. Quality of life was best preserved in surveillance-only series. Following endocrine therapy, not only impotence and hot flushes were focused upon, but also mental dysfunction and intestinal dysfunction from nonsteroidal antiandrogens; additonally, the importance of effective palliation was highlighted. A Quality of Life Questionnaire should contain general domains relevant to cancer patients, cancer-specific questions, and prostate-cancer-specific questions. The latter group includes: worry for prostate cancer and its prognosis, bone/pelvic pain, lower urinary tract symptoms, urinary incontinence, urinary diversion, bowel function, sexual function, endocrine effects, and satisfaction with medical care for prostate cancer. Conclusions. A modern trial of prostate cancer treatment should be regarded as insufficient without including a validated Quality of Life Questionnaire. (C) 1997, Elsevier Science Inc. C1 KAROLINSKA HOSP,DEPT UROL,S-17176 STOCKHOLM,SWEDEN. KRANKENHAUS BARMHERZIGEN BRUDER,DEPT UROL,MUNICH,GERMANY. MASSACHUSETTS GEN HOSP,GEN INTERNAL MED UNIT,MED PRACTICES EVALUAT CTR,BOSTON,MA 02114. UNIV MUNSTER,DEPT UROL,D-4400 MUNSTER,GERMANY. LINKOPING UNIV,CTR MED TECHNOL ASSESSMENT,LINKOPING,SWEDEN. NORWEGIAN RADIUM HOSP,DEPT ONCOL,OSLO,NORWAY. EORTC DATA CTR,BRUSSELS,BELGIUM. CHRISTIAN ALBRECHTS UNIV KIEL,DEPT GEN & THORAC SURG,KIEL,GERMANY. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. DETROIT MED CTR,DEPT RADIAT ONCOL,DETROIT,MI. KAROLINSKA HOSP,DEPT CANC EPIDEMIOL,SE-17176 STOCKHOLM,SWEDEN. NR 48 TC 59 Z9 60 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD APR PY 1997 VL 49 IS 4A SU S BP 66 EP 76 DI 10.1016/S0090-4295(99)80325-2 PG 11 WC Urology & Nephrology SC Urology & Nephrology GA WU208 UT WOS:A1997WU20800008 PM 9111616 ER PT J AU Nichols, TD Wolf, DC Rogers, HB Beyrouty, CA Reynolds, CM AF Nichols, TD Wolf, DC Rogers, HB Beyrouty, CA Reynolds, CM TI Rhizosphere microbial populations in contaminated soils SO WATER AIR AND SOIL POLLUTION LA English DT Article DE bioremediation; phytoremediation; polycyclic aromatic hydrocarbons; petroleum ID BIOREMEDIATION; HYDROCARBONS AB Rhizosphere microbial populations may increase bioremediation of soil contaminated with organic chemicals. A growth chamber study was conducted to evaluate rhizosphere microbial populations in contaminated and non-contaminated soil. Alfalfa (Medicago sativa L.) and alpine bluegrass (Poa alpina L.) were grown in soil containing a mixture of organic chemicals for 14 weeks. The equal millimolar mixture of hexadecane, (2,2-dimethylpropyl)benzene, cis-decahydronaphthalene (decalin), benzoic acid, phenanthrene, and pyrene was added at levels of 0 and 2000 mg/kg. Organic chemical degrader (OCD) populations were assessed by a Most-Probable-Number technique, and bacteria and fungi were enumerated by plate count methods. Different methods for expressing OCD rhizosphere populations were investigated to determine the effect it had on interpretation of the results. At 9 weeks, the OCD numbers were significantly higher in rhizosphere and contaminated soils than in bulk and non-contaminated soils, respectively. Alfalfa rhizosphere OCD levels were 4 x 10(7)/g for contaminated and 6 x 10(6)/g for non-contaminated soils. Bluegrass rhizosphere OCD levels were 1 x 10(7)/g and 1 x 10(6)/g in contaminated and non-contaminated soils, respectively. Selective enrichment of OCD populations was observed in contaminated rhizosphere soil. Higher numbers of OCD in contaminated rhizospheres suggest potential stimulation of bioremediation around plant roots. C1 UNIV ARKANSAS,DEPT AGRON,FAYETTEVILLE,AR 72701. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. NR 35 TC 109 Z9 138 U1 0 U2 10 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0049-6979 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD APR PY 1997 VL 95 IS 1-4 BP 165 EP 178 DI 10.1023/A:1026403923435 PG 14 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA WV507 UT WOS:A1997WV50700013 ER PT J AU Chao, PT Hobbs, BF AF Chao, PT Hobbs, BF TI Decision analysis of shoreline protection under climate change uncertainty SO WATER RESOURCES RESEARCH LA English DT Article ID WATER-RESOURCES; IMPACTS AB If global warming occurs, it could significantly affect water resource distribution and availability. Yet it is unclear whether the prospect of such change is relevant to water resources management decisions being made today. We model a shoreline protection decision problem with a stochastic dynamic program (SDP) to determine whether consideration of the possibility of climate change would alter the decision. Three questions are addressed with the SDP: (1) How important is climate change compared to other uncertainties?, (2) What is the economic loss if climate change uncertainty is ignored?, and (3) How does belief in climate change affect the timing of the decision? In the case study, sensitivity analysis shows that uncertainty in real discount rates has a stronger effect upon the decision than belief in climate change. Nevertheless, a strong belief in climate change makes the shoreline protection project less attractive and often alters the decision to build it. C1 JOHNS HOPKINS UNIV,DEPT GEOG & ENVIRONM ENGN,BALTIMORE,MD 21218. RP Chao, PT (reprint author), USA,CORPS ENGINEERS,INST WATER RESOURCES,7701 TELEGRAPH RD,ALEXANDRIA,VA 22315, USA. RI Hobbs, Benjamin/A-3291-2010 NR 26 TC 12 Z9 12 U1 0 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD APR PY 1997 VL 33 IS 4 BP 817 EP 829 DI 10.1029/96WR03496 PG 13 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA WQ778 UT WOS:A1997WQ77800028 ER PT J AU Buttner, WJ Findlay, M Vickers, W Davis, WM Cespedes, ER Cooper, S Adams, JW AF Buttner, WJ Findlay, M Vickers, W Davis, WM Cespedes, ER Cooper, S Adams, JW TI In situ detection of trinitrotoluene and other nitrated explosives in soils SO ANALYTICA CHIMICA ACTA LA English DT Article DE environmental sensors; electrochemical sensors; amperometric sensors; thermal decomposition; amperometry; trinitrotoluene; TNT; RDX; HMX; explosives; soils AB The thermal decomposition of 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), and other explosives over heated noble metal surfaces generates characteristic products that can be efficiently detected by amperometric gas sensors. This observation was exploited to develop a method for the selective in situ detection and quantitation of explosives contamination in soils. Amperometric sensing of the compounds generated from the thermal decomposition of soil-bound TNT was selective and sensitive over a broad range. Laboratory and field-usable probes that accommodate the electrochemical sensors, the thermal desorption/catalyzer unit or ''heater'', and pneumatic components were designed, fabricated, and deployed. A field test demonstrated that this method is viable for in situ analysis of explosives. C1 USA,WATERWAYS EXPT STN,VICKSBURG,MS 39180. TRANSDUCER RES INC,AURORA,IL 60504. NR 14 TC 43 Z9 43 U1 1 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD MAR 31 PY 1997 VL 341 IS 1 BP 63 EP 71 DI 10.1016/S0003-2670(96)00507-7 PG 9 WC Chemistry, Analytical SC Chemistry GA WU641 UT WOS:A1997WU64100007 ER PT J AU Dhar, NK Zandian, M Pasko, JG Arias, JM Dinan, JH AF Dhar, NK Zandian, M Pasko, JG Arias, JM Dinan, JH TI Planar p-on-n HgCdTe heterostructure infrared photodiodes on Si substrates by molecular beam epitaxy SO APPLIED PHYSICS LETTERS LA English DT Article ID ARRAYS; CDTE AB We have developed a low temperature procedure for molecular beam epitaxy of CdTe buffer layers on {211} Si wafers and have used Si/ZnTe/CdTe composite substrates for molecular beam epitaxy of double layer Hg1-xCdxTe heterostructures. Planar p-on-n double layer heterostructures were formed by an implantation technique and test diodes were fabricated and characterized. At 77 K, devices with 30x30 mu m(2) junction area had R(0)A values in the range 1.5x10(6)-1x10(7) Omega cm(2) with a uniform cut-off wavelength of 4.65 mu m. (C) 1997 American Institute of Physics. C1 ROCKWELL INT SCI CTR,THOUSAND OAKS,CA 91360. NIGHT VIS & ELECT SENSORS DIRECTORATE,FT BELVOIR,VA 22060. RP Dhar, NK (reprint author), USA,RES LAB,FT BELVOIR,VA 22060, USA. NR 10 TC 47 Z9 48 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 31 PY 1997 VL 70 IS 13 BP 1730 EP 1732 DI 10.1063/1.118683 PG 3 WC Physics, Applied SC Physics GA WT571 UT WOS:A1997WT57100032 ER PT J AU Reyes, AE Perez, DR Alvarez, A Garrido, J Gentry, MK Doctor, BP Inestrosa, NC AF Reyes, AE Perez, DR Alvarez, A Garrido, J Gentry, MK Doctor, BP Inestrosa, NC TI A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID ALZHEIMERS-DISEASE; CHOLINESTERASES; PATHOGENESIS; MECHANISM; KINETICS; PROTEIN AB A monoclonal antibody (mAb) 25B1 directed against fetal bovine serum acetylcholinesterase (FBS AChE) was used to examine the ability of the cholinergic enzyme to promote the assembly of amyloid-beta peptides (A beta) into Alzheimers fibrils, This mAb binds to the peripheral anionic site of the enzyme and allosterically inhibits catalytic activity of FBS AChE. Several techniques, including thioflavine-T fluorescence, turbidity, and negative-staining at the electron microscopy level, were used to assess amyloid formation, Inhibition of amyloid formation was dependent on the molar ratio AChE:mAb 25B1, and at least 50% of the inhibition of the AChE promoting effect occurs at a molar ratio similar to that required for inhibition of the esterase activity, Our results suggest that mAb 25B1 inhibits the promotion of the amyloid fibril formation triggered by AChE by affecting the lag period of the A beta aggregation process, (C) 1997 Academic Press. C1 PONTIFICIA UNIV CATOLICA CHILE,FAC CIENCIAS BIOL,DEPT BIOL CELULAR & MOL,SANTIAGO,CHILE. WALTER REED ARMY MED CTR,DIV BIOCHEM,WASHINGTON,DC 20307. NR 17 TC 71 Z9 74 U1 0 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD MAR 27 PY 1997 VL 232 IS 3 BP 652 EP 655 DI 10.1006/bbrc.1997.6357 PG 4 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA WT615 UT WOS:A1997WT61500014 PM 9126330 ER PT J AU Zhou, PG Samuelson, L Alva, KS Chen, CC Blumstein, RB Blumstein, A AF Zhou, PG Samuelson, L Alva, KS Chen, CC Blumstein, RB Blumstein, A TI Ultrathin films of amphiphilic ionic polyacetylenes SO MACROMOLECULES LA English DT Article ID CONDUCTING POLYMERS; POLYMERIZATION AB Thin films of amphiphilic ionic polyacetylenes based on poly (N-octadecyl-2-ethynylpyridinium bromide) were formed using the Langmuir-Blodgett and layer-by-layer deposition techniques. The surface pressure-molecular area isotherms of the monolayers of these polymers at the air-water interface indicate that the alkyl (octadecyl) chains of the repeating units are oriented perpendicularly to the water surface while the rigid conjugated polymer backbones are located within the planar layer of the interface. The molecular organization of transferred polymer multilayers has been also studied by FT-IR, ATR, GAR, and ellipsometry. As a result of this study, a model of the molecular organization of ultrathin films is proposed, in which the conjugated backbone chains of the polymer molecules are oriented parallel to the substrate and are sandwiched between layers of interdigitated octadecyl groups. The electrical conductivity of the polymer films was found to increase substantially upon doping with iodine. Enhanced gas permeability and permselectivity of membranes from Nafion were achieved by deposition of ultrathin films of the above polyacetylene on these membranes. C1 UNIV MASSACHUSETTS,DEPT CHEM,POLYMER SCI PROGRAM,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. UNIV MASSACHUSETTS,DEPT PHYS,CTR ADV MAT,LOWELL,MA 01854. NR 17 TC 27 Z9 27 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD MAR 24 PY 1997 VL 30 IS 6 BP 1577 EP 1581 DI 10.1021/ma960760n PG 5 WC Polymer Science SC Polymer Science GA WP909 UT WOS:A1997WP90900007 ER PT J AU Korona, T Williams, HL Bukowski, R Jeziorski, B Szalewicz, K AF Korona, T Williams, HL Bukowski, R Jeziorski, B Szalewicz, K TI Helium dimer potential from symmetry-adapted perturbation theory calculations using large Gaussian geminal and orbital basis sets SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID FULL CONFIGURATION-INTERACTION; MANY-BODY THEORY; GTO BASIS-SETS; HE-HE; DISPERSION-ENERGY; INTERMOLECULAR INTERACTIONS; MOLECULAR INTERACTIONS; BINDING-ENERGY; WEAKEST BOND; ATOMS AB The symmetry-adapted perturbation theory (SAPT) has been employed to calculate an accurate potential energy curve for the helium dimer. For major components of the interaction energy, saturated values have been obtained using extended Gaussian-type geminal bases. Some other, less significant components were computed using a large orbital basis and the standard set of SAPT codes. The remaining small fraction of the interaction energy has been obtained using a nonstandard SAPT program specific for two-electron monomers and the supermolecular full configuration interaction (FCI) calculations in a moderately large orbital basis. Accuracy of the interaction energy components has been carefully examined. The most accurate to date values of the electrostatic, exchange, induction, and dispersion energies are reported for distances from 3.0 to 7.0 bohr. After adding the retardation correction predicted by the Casimir theory, our new potential has been shown [A. R. Janzen and R. A. Aziz (submitted)] to recover the known bulk and scattering data for helium more accurately than other existing ab initio and empirical potentials. However, the calculated dissociation energy of 1.713 mK and the bond length of 45.8 Angstrom differ somewhat from the values inferred recently from a transmission experiment using nanoscale sieves. (C) 1997 American Institute of Physics. C1 UNIV DELAWARE, DEPT PHYS & ASTRON, NEWARK, DE 19716 USA. USA, RES LAB,AMSRL,WT,PC, WEAPONS TECHNOL DIRECTORATE, ABERDEEN PROVING GROUND, MD 21005 USA. HARVARD SMITHSONIAN CTR ASTROPHYS, CAMBRIDGE, MA 02138 USA. RP Korona, T (reprint author), UNIV WARSAW, DEPT CHEM, PASTEURA 1, PL-02093 WARSAW, POLAND. RI Korona, Tatiana/E-8290-2011 OI Korona, Tatiana/0000-0001-7169-3412 NR 80 TC 247 Z9 250 U1 1 U2 23 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD MAR 22 PY 1997 VL 106 IS 12 BP 5109 EP 5122 DI 10.1063/1.473556 PG 14 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA WN881 UT WOS:A1997WN88100030 ER PT J AU Carrieri, AH AF Carrieri, AH TI Panoramic infrared-imaging spectroradiometer model with reverse phase-modulated beam broadcasting SO APPLIED OPTICS LA English DT Article DE panoramic object scene; infrared image; birefringent interferometer; photoelastic modulation; Mueller matrix; Fourier transform; remote detection AB The optical design of a passive remote sensor, a panoramic spectroradiometer (PANSPEC), and its computer-simulated image performance are presented. PANSPEC monitors the surrounding infrared environment for chemical clouds, detecting a presence once absorption or emission spectra characteristic of the chemical species are resolved. PANSPEC broadcasts chemical presence and cloud heading when equipped with a laser transmitter that projects a polarized laser beam source with phase encryption back through the optical system into object space. Various merit functions were programmed and accessed during computer optimization runs for shaping and positioning of the instrument's semishell entrance window, collector, collimator, interferometer, and imager. The result is a balanced near-diffraction-limited circular image, 6.3 mm across with 10-line pairs/mm spatial resolution at 50% modulation, and an f/2.3 working speed. (C) 1997 Optical Society of America. RP Carrieri, AH (reprint author), USA,CHEM & BIOL DEF COMMAND,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010, USA. NR 12 TC 4 Z9 5 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAR 20 PY 1997 VL 36 IS 9 BP 1952 EP 1964 DI 10.1364/AO.36.001952 PG 13 WC Optics SC Optics GA WN598 UT WOS:A1997WN59800016 PM 18250886 ER PT J AU Rosen, JM Pinnick, RG Garvey, DM AF Rosen, JM Pinnick, RG Garvey, DM TI Measurement of extinction-to-backscatter ratio for near-surface aerosols SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID SOUTHWESTERN UNITED-STATES; SIZE SHAPE DISTRIBUTIONS; LIGHT-SCATTERING; TROPOSPHERIC AEROSOLS; OPTICAL-PROPERTIES; PARTICLES; WAVELENGTH; VOLATILITY; LIDAR AB A method for measuring the local extinction-to-backscatter ratio of atmospheric aerosols is described and demonstrated using aerosols indigenous to the arid southwestern United States. The approach employs simultaneous observations from two separate devices: one a nephelometer (for the extinction measurement) and the other a backscattersonde operated at ground level (for the backscatter measurement). Since the instruments may be deficient in measuring the true scattering coefficients for some aerosols, optical response models are employed to estimate the magnitude of possible errors and make modest corrections to improve the accuracy of the final values. It is found that the measured extinction-to-backscatter ratio is similar to the values calculated from a simple optical model employing homogeneous spherical aerosols with sizes and bulk composition comparable to the aerosol associated with the measurements. Thus possible nonspherical particle scattering effects were not distinctly observed for the aerosols sampled. C1 USA, RES LAB, ADELPHI, MD 20783 USA. RP Rosen, JM (reprint author), UNIV WYOMING, DEPT PHYS & ASTRON, LARAMIE, WY 82071 USA. NR 26 TC 19 Z9 19 U1 2 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD MAR 20 PY 1997 VL 102 IS D5 BP 6017 EP 6024 DI 10.1029/97JD00005 PG 8 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA WQ021 UT WOS:A1997WQ02100014 ER PT J AU Ngo, D Videen, G Dalling, R AF Ngo, D Videen, G Dalling, R TI Chaotic light scattering from a system of osculating, conducting spheres SO PHYSICS LETTERS A LA English DT Article AB Feedback in the equations describing the scattering coefficients cause chaotic behavior in the scattering intensities from a system composed of a pair of osculating spheres. Unlike other systems which display chaos as a trajectory in phase space, this system exhibits chaotic behavior in a partial summation. As the region of osculation increases, tell-tale signs of chaos emerge, and the Lyapunov exponent, a measure of the system's mean rate of exponential error growth, is shown to be greater than zero in these chaotic regions. We show bifurcation diagrams which depict regions of transformation from stability to chaos, including periodic windows and super-cycles. C1 USA RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003. RP Ngo, D (reprint author), EDGEWOOD RES & DEV ENGN CTR,E5951,ABERDEEN PROVING GROUND,MD 21010, USA. NR 18 TC 9 Z9 9 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0375-9601 J9 PHYS LETT A JI Phys. Lett. A PD MAR 17 PY 1997 VL 227 IS 3-4 BP 197 EP 202 DI 10.1016/S0375-9601(97)00036-4 PG 6 WC Physics, Multidisciplinary SC Physics GA WN196 UT WOS:A1997WN19600011 ER PT J AU Rosen, DL Sharpless, C McGown, LB AF Rosen, DL Sharpless, C McGown, LB TI Bacterial spore detection and determination by use of terbium dipicolinate photoluminescence SO ANALYTICAL CHEMISTRY LA English DT Article ID STEADY-STATE; FLUORESCENCE AB A new method to detect bacterial endospores and determine their concentration was demonstrated by the addition of a solution of terbium chloride to a suspension of bacterial endospores. The terbium chloride reacted with the calcium dipicolinate in the spore case to form terbium(III) dipicolinate anion. Solid particles, including residual bacterial particles, were removed by filtering. The photoluminescence from the solution was measured as a function of excitation wavelength, emission wavelength, and bacterial endospore concentration. The photoluminescence from terbium(III) dipicolinate anion in the solution was easily identified. C1 DUKE UNIV,DEPT CHEM,DURHAM,NC 27708. RP Rosen, DL (reprint author), USA,RES LAB,AMSRL IS EE,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 15 TC 94 Z9 97 U1 0 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD MAR 15 PY 1997 VL 69 IS 6 BP 1082 EP 1085 DI 10.1021/ac960939w PG 4 WC Chemistry, Analytical SC Chemistry GA WM550 UT WOS:A1997WM55000016 ER PT J AU Hnatiuk, OW Torrington, KG AF Hnatiuk, OW Torrington, KG TI Routine chest radiography after thoracentesis - Response SO ANNALS OF INTERNAL MEDICINE LA English DT Letter RP Hnatiuk, OW (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD MAR 15 PY 1997 VL 126 IS 6 BP 491 EP 492 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA WM530 UT WOS:A1997WM53000016 ER PT J AU Birdsong, RH Kramer, KK deCal, OMY Peele, KA Tuman, DC Ward, TP Thach, AB AF Birdsong, RH Kramer, KK deCal, OMY Peele, KA Tuman, DC Ward, TP Thach, AB TI Ocular mass casualty due to terrorist attack SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 269 EP 269 PN 1 PG 1 WC Ophthalmology SC Ophthalmology GA WN186 UT WOS:A1997WN18600273 ER PT J AU Krichmar, JL Thomas, ML Rowland, L Sing, HC Thorne, DR AF Krichmar, JL Thomas, ML Rowland, L Sing, HC Thorne, DR TI Pupil dynamics and eye movements as indicators of fatigue and sleepiness SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 PMI INC,ROCKVILLE,MD. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BEHAV BIOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 344 EP 344 PN 1 PG 1 WC Ophthalmology SC Ophthalmology GA WN186 UT WOS:A1997WN18600342 ER PT J AU Zwick, H Elliott, WR Lund, DJ Li, G Schuschereba, ST Edsall, PA AF Zwick, H Elliott, WR Lund, DJ Li, G Schuschereba, ST Edsall, PA TI In vivo measurement of acute laser cellular alteration at the photoreceptor and vascular layers in the small eye SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USAMRD,WALTER REED ARMY INST RES,SAN ANTONIO,TX 78235. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 405 EP 405 PN 1 PG 1 WC Ophthalmology SC Ophthalmology GA WN186 UT WOS:A1997WN18600409 ER PT J AU Robbins, DO Zwick, H Jacobsen, DR Evans, BS Stuck, BE AF Robbins, DO Zwick, H Jacobsen, DR Evans, BS Stuck, BE TI Spatial and temporal effects of Q-switched pulse exposures on visual acuity SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 OHIO WESLEYAN UNIV,DEPT PSYCHOL,DELAWARE,OH 43015. USAMRD,WALTER REED ARMY INST RES,SAN ANTONIO,TX 78235. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 411 EP 411 PN 1 PG 1 WC Ophthalmology SC Ophthalmology GA WN186 UT WOS:A1997WN18600415 ER PT J AU Stuck, BE Scales, DK Zwick, H Lund, DJ Dunlap, W AF Stuck, BE Scales, DK Zwick, H Lund, DJ Dunlap, W TI Early treatment and recovery after simultaneous bilateral injury from Q-switched laser exposure SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,MED RES DETACHMENT,WALTER REED ARMY INST RES,SAN ANTONIO,TX. WILFORD HALL USAF MED CTR,SAN ANTONIO,TX 78236. BROOKE ARMY MED CTR,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 412 EP 412 PN 1 PG 1 WC Ophthalmology SC Ophthalmology GA WN186 UT WOS:A1997WN18600410 ER PT J AU Schuschereba, ST Scales, DK Cross, ME Pizarro, JM Lund, DJ Stuck, BE Marshall, J AF Schuschereba, ST Scales, DK Cross, ME Pizarro, JM Lund, DJ Stuck, BE Marshall, J TI Neutrophils are important treatment targets immediately after severe laser retinal injury in human and rabbit retinas SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,MED RES DETACHMENT,WALTER REED ARMY INST RES,SAN ANTONIO,TX. WILFORD HALL USAF MED CTR,SAN ANTONIO,TX 78236. UNIV LONDON,UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,ST THOMAS HOSP,LONDON,ENGLAND. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 413 EP 413 PN 1 PG 1 WC Ophthalmology SC Ophthalmology GA WN186 UT WOS:A1997WN18600411 ER PT J AU Scales, DK Zwick, H Stuck, BE Lund, DJ Schuschereba, ST AF Scales, DK Zwick, H Stuck, BE Lund, DJ Schuschereba, ST TI Repeated accidental retinal exposures in two observers of argon laser trabeculoplasty SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WILFORD HALL USAF MED CTR,SAN ANTONIO,TX 78236. WALTER REED ARMY INST RES,USA,MED RES DETACHMENT,BROOKS AFB,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 417 EP 417 PN 1 PG 1 WC Ophthalmology SC Ophthalmology GA WN186 UT WOS:A1997WN18600421 ER PT J AU Ness, J Zwick, H Molchany, J Stuck, BE AF Ness, J Zwick, H Molchany, J Stuck, BE TI Alteration in contrast sensitivity, target preferred retinal location (PRL) and accommodation induced by artificial scotoma presentation SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USAMRD,WALTER REED ARMY INST RES,SAN ANTONIO,TX 78235. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 421 EP 421 PN 1 PG 1 WC Ophthalmology SC Ophthalmology GA WN186 UT WOS:A1997WN18600419 ER PT J AU Peele, KA Przbyla, VA AF Peele, KA Przbyla, VA TI An orbital prosthesis for challenging anophthalmic sockets SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 562 EP 562 PN 1 PG 1 WC Ophthalmology SC Ophthalmology GA WN186 UT WOS:A1997WN18600560 ER PT J AU Barnes, SD Campagna, JA Dirks, MS Geanon, JD Doe, EA AF Barnes, SD Campagna, JA Dirks, MS Geanon, JD Doe, EA TI Comparison of Brimonidine 0.2% to Apraclonidine 1.0% for the control of intraocular pressure spikes after argon laser trabeculoplasty SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 2597 EP 2597 PN 1 PG 1 WC Ophthalmology SC Ophthalmology GA WN186 UT WOS:A1997WN18602589 ER PT J AU Elliott, WR Shipman, DL Kavanagh, JT Sponsel, WE Ness, J AF Elliott, WR Shipman, DL Kavanagh, JT Sponsel, WE Ness, J TI Scanning laser measurements in Dorzolamide and placebo treated eyes: Arteriovenous passage times in large and small retinal vessels during hyper- and hypocapnia. SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USN,MED RES INST DET,GEO CTR INC,LASER GRP,BROOKS AFB,TX. UNIV TEXAS,HLTH SCI CTR,DEPT OPHTHALMOL,SAN ANTONIO,TX 78284. USA,MRD,WRAIR,BROOKS AFB,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 3594 EP 3594 PN 2 PG 1 WC Ophthalmology SC Ophthalmology GA WN215 UT WOS:A1997WN21500419 ER PT J AU Rohaly, AM Karsh, R AF Rohaly, AM Karsh, R TI Competing tasks in competing eyes: The effects of dividing attention dichoptically SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,RES LAB,HUMAN RES & ENGN DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 4260 EP 4260 PN 2 PG 1 WC Ophthalmology SC Ophthalmology GA WN215 UT WOS:A1997WN21501083 ER PT J AU Phillips, PJ Gutta, S Singh, D Wechsler, H AF Phillips, PJ Gutta, S Singh, D Wechsler, H TI Human face recognition performances on a generic surveillance task SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,RES LAB,AMSRL,SE,SE,ADELPHI,MD 20783. GEORGE MASON UNIV,DEPT COMP SCI,FAIRFAX,VA 22030. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 4670 EP 4670 PN 2 PG 1 WC Ophthalmology SC Ophthalmology GA WN215 UT WOS:A1997WN21501492 ER PT J AU Johnston, AJ Dirks, MS Teichman, MH Muirhead, JT AF Johnston, AJ Dirks, MS Teichman, MH Muirhead, JT TI Laser safety goggles: Are urologists color blind? SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 4707 EP 4707 PN 2 PG 1 WC Ophthalmology SC Ophthalmology GA WN215 UT WOS:A1997WN21501529 ER PT J AU Rabin, J AF Rabin, J TI Cone-specific contrast sensitivity and visual acuity: A new approach for quantifying human color vision SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,AEROMED RES LAB,FT RUCKER,AL 36362. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 4730 EP 4730 PN 2 PG 1 WC Ophthalmology SC Ophthalmology GA WN215 UT WOS:A1997WN21501552 ER PT J AU Sanford, DK deCal, OEMY Belyea, DA AF Sanford, DK deCal, OEMY Belyea, DA TI Response of intraocular pressure to retrobulbar and peribulbar anesthesia SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WILLIAM BEAUMONT ARMY MED CTR,EL PASO,TX 79920. MAINE EYE CTR,PORTLAND,ME. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 4928 EP 4928 PN 2 PG 1 WC Ophthalmology SC Ophthalmology GA WN215 UT WOS:A1997WN21501749 ER PT J AU Kosakura, KH Ebright, PA Hann, CM Ng, W vandePol, C Klein, SA AF Kosakura, KH Ebright, PA Hann, CM Ng, W vandePol, C Klein, SA TI Accuracy of videokeratography in predicting rigid contact lens fits with different base curves SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 UNIV CALIF BERKELEY,SCH OPTOMETRY,BERKELEY,CA 94720. USA,DEPT MED,BERKELEY,CA. NEUROMETR INST,BERKELEY,CA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 5090 EP 5090 PN 2 PG 1 WC Ophthalmology SC Ophthalmology GA WN215 UT WOS:A1997WN21501911 ER PT J AU Casey, P Lloyd, WC Giovannini, J Bauman, W AF Casey, P Lloyd, WC Giovannini, J Bauman, W TI Treatment of Aspergillus endophthalmitis: A prospective, masked trial of the effect of intravitreal amphotericin B and dexamethasone in the rabbit model. SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WILFORD HALL USAF MED CTR,DEPT OPHTHALMOL,LACKLAND AFB,TX 78236. BROOKE ARMY MED CTR,DEPT OPHTHALMOL,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1997 VL 38 IS 4 BP 5198 EP 5198 PN 2 PG 1 WC Ophthalmology SC Ophthalmology GA WN215 UT WOS:A1997WN21502019 ER PT J AU Skeeles, JK Smith, MRM AF Skeeles, JK Smith, MRM TI Sarajevo's graduates traveled long, hard road SO JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Editorial Material RP Skeeles, JK (reprint author), USA,COMBINED JOINT CIVIL MIL TASK FORCE,WASHINGTON,DC, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 SN 0003-1488 J9 J AM VET MED ASSOC JI J. Am. Vet. Med. Assoc. PD MAR 15 PY 1997 VL 210 IS 6 BP 743 EP 743 PG 1 WC Veterinary Sciences SC Veterinary Sciences GA WM860 UT WOS:A1997WM86000004 ER PT J AU Barth, J AF Barth, J TI Maye & Faye's building & loan: The story of a remarkable sisterhood - Smith,M, Hudson,F, Whitaker,L SO LIBRARY JOURNAL LA English DT Book Review RP Barth, J (reprint author), US MIL ACAD LIB,W POINT,NY, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 15 PY 1997 VL 122 IS 5 BP 71 EP 71 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA WM191 UT WOS:A1997WM19100110 ER PT J AU Holz, JC Hoagland, KD Spawn, RL Popp, A Andersen, JL AF Holz, JC Hoagland, KD Spawn, RL Popp, A Andersen, JL TI Phytoplankton community response to reservoir aging, 1968-92 SO HYDROBIOLOGIA LA English DT Article DE reservoir aging; phytoplankton; turbidity; sedimentation; eutrophication ID WATERS; CHLOROPHYLL; PHOSPHORUS; PRODUCTIVITY; TURBIDITY; ALGAE; LAKES; CLAY AB The effects of reservoir aging on the phytoplankton community of a midwestern U.S. reservoir constructed in 1965 (Pawnee Reservoir) were studied by comparing algal biovolume and species composition from April 1992 through November 1992 to surveys conducted in 1968-73 and 1990. Mean summer total phosphorus, nitrate-nitrogen, Secchi disk depth, total suspended solids, chlorophyll a, and phytoplankton species composition data characterized Pawnee Reservoir during 1968-69 as a high nutrient, relatively clear water environment. Phytoplankton biomass was relatively low, consisting mainly of cyanophytes and non-flagellated chlorophytes. During 1970-73, water clarity was poor, total suspended solids were high, and total phosphorus was lower, but was still greater than 100 mu g l(-1). The 1970-73 phytoplankton biomass was high and was dominated by cyanophytes. Mean summer total phosphorus remained > 100 mu g l(-1), water clarity remained poor, but phytoplankton biomass decreased significantly during 1990-92. The dramatic drop in chlorophyll a and low mean volatile suspended solids indicated that inorganic suspended sediments, rather than phytoplankton, accounted for the majority of the turbidity in 1990-92. In addition to lower phytoplankton biomass, community composition shifted away from buoyancy-regulating cyanophytes toward flagellated chlorophytes. These data suggest that as reservoirs located in agricultural watersheds age, (1) inorganic suspended sediments have a significant effect on the light environment as well as phytoplankton biomass and species composition, (2) the control of phytoplankton biomass and species composition shifts away from nutrients to light and suspended sediments, and (3) there is a 1-2 year lag in the response of phytoplankton biomass to maximum nutrient loading during the trophic upsurge period. Thus, sedimentation has been shown to be a primary determinant of plankton and benthic macroinvertebrate community composition as Pawnee Reservoir aged. C1 USA,CORPS ENGINEERS,OMAHA,NE 68102. RP Holz, JC (reprint author), UNIV NEBRASKA,DEPT FORESTRY FISHERIES & WILDLIFE,LINCOLN,NE 68583, USA. NR 41 TC 15 Z9 17 U1 0 U2 6 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD MAR 14 PY 1997 VL 346 BP 183 EP 192 DI 10.1023/A:1002978302479 PG 10 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA XR916 UT WOS:A1997XR91600014 ER PT J AU Giesen, DJ Chambers, CC Cramer, CJ Truhlar, DG AF Giesen, DJ Chambers, CC Cramer, CJ Truhlar, DG TI Solvation model for chloroform based on class IV atomic charges SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID FREE-ENERGIES; AQUEOUS SOLVATION; HEXADECANE; PARAMETERS; PM3-SM3; WATER; AM1 AB We present a parametrization of the SM5.4 solvation model, previously applied to aqueous solutions and general organic solvents, for predicting free energies of solvation in chloroform. As in all SM5 models, the calculations are based on a set of geometry-based functional forms for parametrizing atomic surface tensions of organic solutes. In particular, the atomic surface tensions depend in some cases on distances to nearby atoms. Combining the atomic surface tensions with electrostatic effects included in a Fock operator by the generalized Born model enables one to calculate free energies of solvation by a quantum mechanical self-consistent reaction field method. Atomic charges are obtained by both the AM1-CM1A and PM3-CM1P class IV charge models, which yield similar results, and hence the same atomic radii and similar surface tension coefficients are used with both charge models. Experimental free energies of solvation and free energies of transfer from aqueous solution are used to parametrize the theory for chloroform. The parametrization is based on a set of 205 neutral solutes containing H, C, N, O, F, S, Cl, Br, and I that we used previously to parameterize a model for general organic solvents plus 32 additional solutes added for this study. For the present parameterization, we used free energies of solvation in chloroform for 88 solutes, free energies of solvation in other solvents for 123 solutes, and free energies of transfer from water to chloroform for 26 other solutes. We obtained a mean unsigned error in the free energies of solvation in chloroform of 0.43 kcal/mol using CM1A atomic charges and 0.34 kcal/mol using CM1P atomic charges. C1 UNIV MINNESOTA,INST SUPERCOMP,DEPT CHEM,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RI Truhlar, Donald/G-7076-2015; Cramer, Christopher/B-6179-2011 OI Truhlar, Donald/0000-0002-7742-7294; Cramer, Christopher/0000-0001-5048-1859 NR 27 TC 58 Z9 58 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 1089-5647 J9 J PHYS CHEM B JI J. Phys. Chem. B PD MAR 13 PY 1997 VL 101 IS 11 BP 2061 EP 2069 DI 10.1021/jp963080v PG 9 WC Chemistry, Physical SC Chemistry GA WM886 UT WOS:A1997WM88600018 ER PT J AU Kronenberg, S Brucker, GJ Bechtel, E Gentner, F Lee, A AF Kronenberg, S Brucker, GJ Bechtel, E Gentner, F Lee, A TI Locating and imaging sources of gamma and X-radiation directly or through thick shields SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT LA English DT Article AB This paper is a continuation of research published earlier. It describes the characterization of sensors that generate images of extended area sources, scatter patterns from irradiated targets, and radiation sources through walls of concrete and lead. Images of the primary sources as well as the photon scatter-patterns from the targets or container walls were produced. The unique directional sensitivity of the sensors made it possible to locate a Cs-137 point source that produced a radiation intensity of 13.4 mu rad (Tissue)/h (about 10 photons/cm(2)-s) at the detector, immersed in a radiation field of 79.8 mu rad (Tissue)/h from another cesium source. Radiation sources of Cs-137, Co-60, and 300 kV X-ray photons were used in the scattering and wall penetration experiments and Th-232 foils in the extended area source measurements. C1 USA,CECOM,NV LAB,FT MONMOUTH,NJ 07703. NR 4 TC 8 Z9 8 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-9002 J9 NUCL INSTRUM METH A JI Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip. PD MAR 11 PY 1997 VL 387 IS 3 BP 401 EP 409 DI 10.1016/S0168-9002(96)01221-1 PG 9 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Nuclear; Physics, Particles & Fields SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA WU323 UT WOS:A1997WU32300011 ER PT J AU Ved, HS Koenig, ML Dave, JR Doctor, BP AF Ved, HS Koenig, ML Dave, JR Doctor, BP TI Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate SO NEUROREPORT LA English DT Article DE acetylcholinesterase; calcium mobilization; cholinesterase inhibitors; enriched primary neuronal cell culture; glutamate toxicity; Huperzine A; neuronal survival ID CALCIUM; ACETYLCHOLINESTERASE; DISEASE; BINDING AB HUPERZINE A, a potential therapeutic agent for Alzheimer's disease, inhibits acetylcholinesterase in primary cultures derived from forebrain, hippocampus, cortex and cerebellum of embryonic rat brain. Glutamate induces cell death in cultures from all these brain regions. Maximum cell toxicity was observed in cerebellar cultures. Pretreatment of cell cultures with Huperzine A reduced cell toxicity, as evidenced by cytotoxicity assay and general morphology. Huperzine A pretreatment also reduced glutamate-induced calcium mobilization, but did not affect elevations in intraneuronal free Ca2+ ([Ca](i)) caused by KCI or (-)Bay K 8644. The data suggest that Huperzine A could be a potent neuroprotective agent not only where cholinergic neurons are impaired, but also under conditions in which glutamatergic functions are compromised. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV NEUROSCI,WASHINGTON,DC 20307. RP Ved, HS (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307, USA. NR 23 TC 86 Z9 95 U1 2 U2 5 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4965 J9 NEUROREPORT JI Neuroreport PD MAR 3 PY 1997 VL 8 IS 4 BP 963 EP 968 DI 10.1097/00001756-199703030-00029 PG 6 WC Neurosciences SC Neurosciences & Neurology GA WU313 UT WOS:A1997WU31300032 PM 9141073 ER PT J AU deSouza, M Song, MS Carr, JK SandersBuell, E Shin, Y Artenstein, AW Lee, H McCutchan, FE Brown, AE AF deSouza, M Song, MS Carr, JK SandersBuell, E Shin, Y Artenstein, AW Lee, H McCutchan, FE Brown, AE TI HIV-1 subtypes A and B isolated from the Republic of Korea SO AIDS LA English DT Letter ID IMMUNODEFICIENCY-VIRUS TYPE-1; VARIANTS C1 HENRY M JACKSON FDN,ROCKVILLE,MD. RP deSouza, M (reprint author), ARMED FORCES RES INST MED SCI,DEPT RETROVIROL,BANGKOK 10400,THAILAND. NR 13 TC 9 Z9 9 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0269-9370 J9 AIDS JI Aids PD MAR PY 1997 VL 11 IS 3 BP 389 EP 391 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA WK692 UT WOS:A1997WK69200021 PM 9147436 ER PT J AU Angueira, CE Kadakia, SC AF Angueira, CE Kadakia, SC TI Esophageal stents for inoperable esophageal cancer: Which to use? SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Editorial Material ID EXPANDING METAL STENTS; PALLIATION; OBSTRUCTION; CARCINOMA; STENOSIS; IMPLANTATION; EXPERIENCES; STRICTURES; THERAPY C1 BROOKE ARMY MED CTR,DEPT MED,SAN ANTONIO,TX 78234. RP Angueira, CE (reprint author), BROOKE ARMY MED CTR,GASTROENTEROL SERV,SAN ANTONIO,TX 78234, USA. NR 24 TC 10 Z9 10 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD MAR PY 1997 VL 92 IS 3 BP 373 EP 376 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA WL819 UT WOS:A1997WL81900002 PM 9068454 ER PT J AU Jones, MP RuedaPedraza, ME AF Jones, MP RuedaPedraza, ME TI Extranodal sinus histiocytosis with massive lymphadenopathy presenting as an intramedullary spinal cord tumor: A case report SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Article DE sinus histiocytosis; spinal cord tumor; Rosai-Dorfman disease ID ROSAI-DORFMAN DISEASE AB Involvement of the central nervous system by sinus histiocytosis with massive lymphadenopathy (SHML) is rare. Less than 30 cases have been reported. To the best of our knowledge, we describe the first case of an intramedullary spinal cord lesion which occurred in a 34-year-old black male, causing paraplegia. Laboratory evaluation revealed anemia, increased erythrocyte sedimentation rate, and polyclonal gammopathy. Microscopic examination of the lesion revealed lymphocytes within the cytoplasm of the histiocytic cells, a phenomenon known as emperipolesis. Immunohistochemical stains showed the large eosinophilic histiocytic cells to be positive for S-100 protein and Kp1 antigen. Special stains for fungi and acid-fast organisms were negative. There was no evidence of clonality in the lymphocytic aggregates. Glial fibrillary acidic protein was negative in the lesion, although positive in the surrounding tissue. These features confirmed the diagnosis of extranodal SHML involving the intramedullary spinal cord. (C) 1997 Wiley-Liss, Inc. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. RP Jones, MP (reprint author), WALTER REED ARMY MED CTR,DEPT HEMATOL ONCOL,WASHINGTON,DC 20307, USA. NR 18 TC 13 Z9 13 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD MAR PY 1997 VL 54 IS 3 BP 253 EP 257 PG 5 WC Hematology SC Hematology GA WL892 UT WOS:A1997WL89200013 PM 9067506 ER PT J AU Rademaker, J Rosenberg, ZS Beltran, J Colon, E AF Rademaker, J Rosenberg, ZS Beltran, J Colon, E TI Alterations in the distal extension of the musculus peroneus brevis with foot movement SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID TENDON SUBLUXATION; INJURIES; MUSCLE AB OBJECTIVE. A low-lying belly of the musculus peroneus brevis (presence of muscle tissue within the fibular groove) is said to be a risk factor for rupture or dislocation of the peroneal tendons. However, alterations in foot position may affect the position of the musculotendinous junction. The purpose of this study was to evaluate the normal position of the musculotendinous junction of the musculus peroneus brevis in full dorsiflexion and plantar flexion. MATERIALS AND METHODS. The ankles of 12 adult asymptomatic volunteers were imaged in full dorsiflexion and plantar flexion. The number of scans between the fibular groove and the first scan imaging the muscle belly of the musculus peroneus brevis was documented in each patient in full dorsiflexion and plantar flexion. RESULTS. Distal extension of muscle belly into or beyond the fibular groove was present in 11 subjects in dorsiflexion and in seven subjects in plantar flexion. CONCLUSION. Extension of the muscle belly of musculus peroneus brevis into and distal to the fibular groove is part of the normal excursion of the muscle during foot motion. Care should be taken not to misdiagnose this normal finding as a pathologic condition when interpreting MR studies of the ankle. C1 HOSP JOINT DIS & MED CTR,INST ORTHOPAED,DEPT RADIOL,NEW YORK,NY 10003. BETH ISRAEL MED CTR,DEPT MED,NEW YORK,NY 10003. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. NR 14 TC 11 Z9 11 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAR PY 1997 VL 168 IS 3 BP 787 EP 789 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA WJ628 UT WOS:A1997WJ62800043 PM 9057535 ER PT J AU Fengler, SA Abcarian, H AF Fengler, SA Abcarian, H TI The York Mason approach to repair of iatrogenic rectourinary fistulae SO AMERICAN JOURNAL OF SURGERY LA English DT Article AB BACKGROUND: We report our experience of 8 patients who underwent repair of iatrogenic rectourinary fistulae via the transsphincteric (York Mason) approach. PATIENTS AND METHODS: Eight patients developed rectourinary fistulae in the course of treatment of prostate cancer. Three fistulae developed after radiation therapy alone, three after prostatectomy, and two after both surgery and radiation therapy. Five patients underwent fecal diversion in conjunction with repair. RESULTS: All fistulae remained closed after repair. All patients were continent of stool after primary surgery or after colostomy closure if they had been diverted. Two patients had complications associated with urethral catheters that resolved with changing the catheters. CONCLUSION: The transsphincteric (York Mason) approach in the repair of rectourinary fistulae results in successful closure of the fistulae without impairment of continence to stool. This procedure is much simpler than complicated transabdominal or transperineal approaches to these fistulae. (C) 1997 by Excerpta Medica, Inc. C1 UNIV ILLINOIS,DEPT SURG,CHICAGO,IL. RP Fengler, SA (reprint author), UNIFORMED SERV UNIV HLTH SCI,BROOKE ARMY MED CTR,DEPT SURG,F EDWARD HEBERT SCH MED,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 39 Z9 39 U1 1 U2 1 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD MAR PY 1997 VL 173 IS 3 BP 213 EP 217 DI 10.1016/S0002-9610(96)00015-3 PG 5 WC Surgery SC Surgery GA WR008 UT WOS:A1997WR00800015 PM 9124629 ER PT J AU ScottWright, A Hakre, S Bryan, JP Jaramillo, R Reyes, LG Cruess, D Macarthy, PO Gaydos, JC AF ScottWright, A Hakre, S Bryan, JP Jaramillo, R Reyes, LG Cruess, D Macarthy, PO Gaydos, JC TI Hepatitis B virus, human immunodeficiency virus type-1, and syphilis among women attending prenatal clinics in Belize, Central America SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HEPATOCELLULAR-CARCINOMA; HETEROSEXUAL TRANSMISSION; UNITED-STATES; INFECTION; PREVALENCE; PREVENTION; INFANTS; MOTHERS; TAIWAN; RISK AB Women and their infants may benefit from therapeutic interventions when hepatitis B, human immunodeficiency virus (HIV), or syphilis are detected during the prenatal period. We initiated hepatitis B and HIV screening of women attending prenatal clinics in Belize. Risk factor assessment information for hepatitis B infection and demographic data were determined by interview. Of 543 evaluable women, 81 (14.9%) were seropositive for hepatitis B core antibody (anti-HBc); one woman had asymptomatic hepatitis B surface antigenemia. Antibodies to HIV-1 were detected in one woman. Reactive syphilis serologies were detected in 15 (2.8%) women. Anti-HBc seroprevalence varied by district (range 3.1-43.5%) and by ethnicity (range 0.0-40.98). Significant identified risks for anti-HBc seropositivity from univariate analyses included being of the Garifuna ethnic group, residence or birth in the Stann Creek or Toledo districts, a reactive syphilis serology, a household size of eight or greater, and five or more lifetime sexual partners. Multivariate analyses identified ethnicity and a reactive rapid plasma reagin as the best predictors of anti-HBc seropositivity. Highly variable differences in anti-HBc prevalence by district may permit the targeting of limited public health resources for education, screening, and prevention programs. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR,BETHESDA,MD 20814. EPIDEMIOL RES CTR,BELIZE CITY,BELIZE. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV VIRAL DIS,WASHINGTON,DC 20307. RI Huang, Linlu/H-3410-2011 NR 33 TC 5 Z9 6 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 1997 VL 56 IS 3 BP 285 EP 290 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA WW087 UT WOS:A1997WW08700006 PM 9129530 ER PT J AU Wilairatana, P Kyle, DE Looareesuwan, S Chinwongprom, K Amradee, S White, NJ Watkins, WM AF Wilairatana, P Kyle, DE Looareesuwan, S Chinwongprom, K Amradee, S White, NJ Watkins, WM TI Poor efficacy of antimalarial biguanide-dapsone combinations in the treatment of acute, uncomplicated falciparum malaria in Thailand SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Article ID PLASMODIUM-FALCIPARUM; QUININE-TETRACYCLINE; MEFLOQUINE; PROGUANIL; SUSCEPTIBILITY; HALOFANTRINE; VARIABILITY; CYCLOGUANIL; ACTIVATION; METABOLISM AB Combinations of dapsone with proguanil or chlorproguanil have proved effective in the treatment of chloroquine-resistant falciparum malaria in Africa and for prophylaxis in Asia. These combinations have not been used for treatment in areas with multi-drug-resistant parasites such as in Thailand. Combinations of dapsone (approximately 4 mg/kg) plus either proguanil (approximately 8 mg/kg; DP regimen; N = 10) or chlorproguanil (approximately 1.4 mg/kg; DC regimen; N = 16) were given once a day for 3 days to adult Thai patients with acute, uncomplicated, falciparum malaria. The two regimens were well tolerated and had no side-effects, but the cure rates, assessed at 28-day follow-up, were only 10% for DP (60% with RI response and 30% with RII) and 14% for DC (29% with RI response and 57% with RII). The mean (S.D.) fever-clearance times in those patients who were cured (S) or whose infections recrudesced (RI response) were 103 (56) h for those given DP and 90 (42) h for those given DC. The corresponding parasite-clearance times were 83 (46) for DP and 53 (21) h for DC. In-vitro susceptibility testing of isolates obtained both before treatment and at recrudescence demonstrated marked resistance to cycloguanil, dapsone, chloroquine and mefloquine. The results demonstrate that short-course treatment with dapsone plus either proguanil or chloproguanil is ineffective for the treatment of falciparum malaria in Thailand. C1 MAHIDOL UNIV,FAC TROP MED,OXFORD TROP MED RES PROGRAMME,BANGKOK 10400,THAILAND. MAHIDOL UNIV,FAC TROP MED,DEPT CLIN TROP MED,BANGKOK,THAILAND. MAHIDOL UNIV,FAC TROP MED,BANGKOK HOSP TROP DIS,BANGKOK,THAILAND. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPT THERAPEUT,WASHINGTON,DC 20307. WELLCOME TRUST RES LAB,NAIROBI,KENYA. RI White, Nicholas/I-4629-2012 NR 26 TC 40 Z9 40 U1 0 U2 0 PU CARFAX PUBL CO PI ABINGDON PA PO BOX 25, ABINGDON, OXFORDSHIRE, ENGLAND OX14 3UE SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD MAR PY 1997 VL 91 IS 2 BP 125 EP 132 PG 8 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA WT282 UT WOS:A1997WT28200001 PM 9307653 ER PT J AU Kinnamon, KE Poon, BT Hanson, WL Waits, VB AF Kinnamon, KE Poon, BT Hanson, WL Waits, VB TI Evidence that certain 8-aminoquinolines are potentially effective drugs against Chagas disease SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Article ID CHEMOTHERAPY; PRIMAQUINE AB Forty 8-aminoquinolines (a chemical class with members having some activity against Trypanosoma cruzi infections) were evaluated for their effectiveness in reducing the 14-day parasitaemias of Cb-week-old, female, albino mice infected with a Brazilian strain of T. cruzi. Six of the compounds were more active or as active as the reference drug, nifurtimox, and one was > 13-fold as efficacious. Certain members of the series tested warrant further evaluation. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPT THERAPEUT,WASHINGTON,DC 20307. UNIV GEORGIA,COLL VET MED,DEPT PARASITOL,ATHENS,GA 30602. NR 14 TC 7 Z9 7 U1 0 U2 1 PU CARFAX PUBL CO PI ABINGDON PA PO BOX 25, ABINGDON, OXFORDSHIRE, ENGLAND OX14 3UE SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD MAR PY 1997 VL 91 IS 2 BP 147 EP 152 PG 6 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA WT282 UT WOS:A1997WT28200004 PM 9307656 ER PT J AU Marion, GM AF Marion, GM TI A theoretical evaluation of mineral stability in Don Juan Pond, Wright Valley, Victoria Land SO ANTARCTIC SCIENCE LA English DT Article DE chemical thermodynamics; FREZCHEM model; mineral equilibria ID CHEMICAL-EQUILIBRIUM; ANTARCTICA; WATERS; LAKES AB Don Juan Pond, located in the Wright Valley, Victoria Land, is unique for several reasons. It is the most saline of the Antarctic lakes, being a near-saturated CaCl2 solution. As a consequence of this high salinity, Don Juan Pond generally remains unfrozen in winter, even at temperatures below -50 degrees C. Don Juan Pond is the site where antarcticite (CaCl2 . 6H(2)O) was first identified forming naturally. The objective of this paper is to demonstrate the utility of a chemical thermodynamic model (FREZCHEM) by developing theoretical stability diagrams for ice, halite (NaCl), hydrohalite (NaCl . 2H(2)O), and antarcticite in Don Juan Pond, using experimental data collected on 34 days between 1961 and 1983. The composition of Don Juan Pond at the calculated eutectic temperature (-51.8 degrees C) was CaCl2 = 3.72 mol kg(-1) and NaCl = 0.50 mol kg(-1), which is similar but not identical to a pure NaCl-CaCl2-H2O system. The low eutectic temperature and high CaCl2 concentrations of Don Juan Pond account for lack of freezing during winter. The model is compatible with the experimental data, and predicts the formation of ice during rare high water periods, halite, and antarcticite. These solid phases have all been reported from Don Juan Pond. The model also predicts the formation of hydrohalite at subzero temperatures; hydrohalite has never been observed at Don Juan Pond, but this may simply reflect that most sampling was done during the summer when halite is thermodynamically more stable than hydrohalite. The FREZCHEM model may prove useful in elucidating the physicochemical behaviour, the origin of salinity, and the evolution of Antarctic lakes. RP Marion, GM (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 29 TC 29 Z9 29 U1 3 U2 17 PU BLACKWELL SCIENCE LTD PI OXFORD PA P O BOX 88, OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0NE SN 0954-1020 J9 ANTARCT SCI JI Antarct. Sci. PD MAR PY 1997 VL 9 IS 1 BP 92 EP 99 PG 8 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA WM780 UT WOS:A1997WM78000011 ER PT J AU Driscoll, JS Mayers, DL Bader, JP Weislow, OS Johns, DG Buckheit, RW AF Driscoll, JS Mayers, DL Bader, JP Weislow, OS Johns, DG Buckheit, RW TI 2'-fluoro-2',3'-dideoxyarabinosyladenine (F-ddA): Activity against drug-resistant human immunodeficiency virus strains and clades A-E SO ANTIVIRAL CHEMISTRY & CHEMOTHERAPY LA English DT Article DE HIV; cross-resistance; F-ddA; clade ID REVERSE-TRANSCRIPTASE INHIBITORS; ANTIRETROVIRAL AGENTS; REDUCED SENSITIVITY; HIV; TYPE-1; SUSCEPTIBILITIES; PHOSPHORYLATION; INFECTION; THERAPY; CELLS AB 2'-Fluoro-2',3'-dideoxyarabinosyladenine (F-ddA), an anti-human immunodeficiency virus (HIV) drug currently in clinical trial, was compared with zidovudine (ATT), ddl and ddC for anti-HIV activity and potency in HIV-1 strains both sensitive and resistant to zidovudine, ddl and non-nucleoside reverse transcriptase inhibitors. A variety of host cell systems [MT-2, MT-4, phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC)] was used. F-ddA was effective against each of the drug-resistant isolates, including the strain resistant to ddl, the other purine dideoxynucleoside evaluated in this study. The anti-HIV-1 activities of F-ddA and zidovudine were also determined against clades A-E in PHA-PBMCs. Although activities were similar, zidovudine was significantly more potent than F-ddA in the PHA-PBMC system. C1 WALTER REED ARMY INST RES,ROCKVILLE,MD 20850. NCI,ANTIVIRAL EVALUAT BRANCH,ROCKVILLE,MD 20852. SRA TECHNOL,ROCKVILLE,MD 20850. FREDERICK CANC RES & DEV CTR,SO RES INST,VIROL RES GRP,FREDERICK,MD 21701. RP Driscoll, JS (reprint author), NCI,MED CHEM LAB,DIV BASIC SCI,NIH,BLDG 37,ROOM 5C-02,BETHESDA,MD 20892, USA. NR 28 TC 16 Z9 17 U1 0 U2 0 PU INT MEDICAL PRESS PI LONDON PA 125 HIGH HOLBORN, LONDON, ENGLAND WC1V 6QA SN 0956-3202 J9 ANTIVIR CHEM CHEMOTH JI Antivir. Chem. Chemother. PD MAR PY 1997 VL 8 IS 2 BP 107 EP 111 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Virology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Virology GA WN489 UT WOS:A1997WN48900004 ER PT J AU Wilson, DK AF Wilson, DK TI Simple, relaxational models for the acoustical properties of porous media SO APPLIED ACOUSTICS LA English DT Article DE porous media; relaxation processes; diffusion; acoustics ID SOUND-PROPAGATION AB By viewing thermal and viscous diffusion in porous media as relaxational processes, a particularly simple, phenomenological model for sound propagation in these materials is developed. The relaxation model parameters (characteristic times) are chosen by comparison to three existing models. Delany and Bazley's empirical equations; the Biot-Allard microstructural model; and Champoux and Stinson's generalized, microstructural model. It is shown that the relaxation model can effectively mimic the Delany-Bazley equations in their valid frequency range; yet, unlike the Delany-Bazley equations, the relaxation model has the advantage providing of realistic predictions at a broad range frequencies. In more exacting applications the characteristic times can be selected in a manner that makes the relaxation model predictions practically indistinguishable from the two microstructural models. The advantage of the relaxation model in these applications is its simple equations. RP Wilson, DK (reprint author), USA,RES LAB,BATTLEFIELD ENVIRONM DIV,AMSRL,IS,EE,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 13 TC 80 Z9 80 U1 0 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0003-682X J9 APPL ACOUST JI Appl. Acoust. PD MAR PY 1997 VL 50 IS 3 BP 171 EP 188 DI 10.1016/S0003-682X(96)00048-5 PG 18 WC Acoustics SC Acoustics GA XC269 UT WOS:A1997XC26900001 ER PT J AU Chen, ZP Kaplan, DL Yang, K Kumar, J Marx, KA Tripathy, SK AF Chen, ZP Kaplan, DL Yang, K Kumar, J Marx, KA Tripathy, SK TI Two-photon-induced fluorescence from the phycoerythrin protein SO APPLIED OPTICS LA English DT Article DE phycobiliprotein; two-photon excitation; fluorescence; biosensors ID 2-PHOTON; PHYCOBILISOMES; MICROSCOPY; STORAGE; LASER AB Two-photon-induced fluorescence is observed from the photodynamic phycobiliprotein phycoerythrin. Temporal, spectral, and intensity-dependent properties of the two-photon-induced fluorescence emission from phycoerythrin excited by a 1.06-mu m laser beam are reported. The measured two-photon absorption cross section of phycoerythrin is an order of magnitude larger than that of Rhodamine 6G. The potential applications of phycobiliproteins for two-photon-induced fluorescence for microscopy of three-dimensional biological samples and three-dimensional optical memory are discussed. (C) 1997 Optical Society of America. C1 USA, NATICK RES DEV & ENGN CTR, DIV BIOTECHNOL, NATICK, MA 01760 USA. UNIV LOWELL, DEPT CHEM, LOWELL, MA 01854 USA. UNIV LOWELL, DEPT PHYS, LOWELL, MA 01854 USA. NR 17 TC 19 Z9 20 U1 2 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAR 1 PY 1997 VL 36 IS 7 BP 1655 EP 1659 DI 10.1364/AO.36.001655 PG 5 WC Optics SC Optics GA WK398 UT WOS:A1997WK39800035 PM 18250850 ER PT J AU Romine, KA Rothschild, JG Hansen, RC AF Romine, KA Rothschild, JG Hansen, RC TI Cicatricial alopecia and keratosis pilaris - Keratosis follicularis spinulosa decalvans SO ARCHIVES OF DERMATOLOGY LA English DT Article ID MULTIPLE TYPES; HAMARTOMA; SOLITARY C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP Romine, KA (reprint author), BAYNE JONES ARMY COMMUNITY HOSP,FT POLK,LA 71459, USA. NR 6 TC 8 Z9 10 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD MAR PY 1997 VL 133 IS 3 BP 381 EP & PG 4 WC Dermatology SC Dermatology GA WN865 UT WOS:A1997WN86500018 PM 9080901 ER PT J AU Callahan, CW Sisler, C AF Callahan, CW Sisler, C TI Use of seating devices in infants too young to sit SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE LA English DT Article ID CAR SEATS; GASTROESOPHAGEAL REFLUX AB Objectives: To determine how frequently seating devices are available in homes with small infants and how often they are used for infants who are too young to sit erect and unsupported. Design: Observational study using a questionnaire administered to a cohort of parents of well infants younger than 5 months. Setting: Well-Baby Clinic, Department of Pediatrics, Tripler Army Medical Center, a tertiary care center serving the population of military dependents on the island of Oahu, Hawaii. Results: Infant seating devices were available in the homes of all of the infants whose parents completed the questionnaire during the study. Of 187 infants, 176 (94%) spent 30 minutes or longer in seating devices each day. The mean (tSD) time spent each day in seating devices was 5.7+/-3.5 hours and ranged from 0 to 16 hours. Conclusions: Seating devices were widely available for use in the care of the infants. Car seats that double as infant carriers and infant seats likely are being used extensively outside of automobiles. Prolonged use of infant seating devices with infants who are too young to sit unsupported may have several potential adverse consequences. C1 TRIPLER ARMY MED CTR,DEPT RADIOL,MCHK PE,HONOLULU,HI 96859. RP Callahan, CW (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,MCHK PE,HONOLULU,HI 96859, USA. NR 15 TC 18 Z9 18 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 1072-4710 J9 ARCH PEDIAT ADOL MED JI Arch. Pediatr. Adolesc. Med. PD MAR PY 1997 VL 151 IS 3 BP 233 EP 235 PG 3 WC Pediatrics SC Pediatrics GA WN486 UT WOS:A1997WN48600003 PM 9080929 ER PT J AU Langenberg, JP VanDijk, C Sweeney, RE Maxwell, DM DeJong, LPA Benschop, HP AF Langenberg, JP VanDijk, C Sweeney, RE Maxwell, DM DeJong, LPA Benschop, HP TI Development of a physiologically based model for the toxicokinetics of C(+/-)P(+/-)-soman in the atropinized guinea pig SO ARCHIVES OF TOXICOLOGY LA English DT Article DE physiologically based model; C(+/-)P(+/-)-soman; stereoisomers; toxicokinetics; guinea pig ID NERVE AGENT SOMAN; 4 STEREOISOMERS; PARTITION-COEFFICIENTS; HUMAN-PLASMA; MICE; RAT; PHARMACOKINETICS; INHIBITION; BIODISPOSITION; MARMOSET AB A physiologically based model was developed which describes the in vivo toxicokinetics of the highly reactive nerve agent C(+/-)P(+/-)-soman at doses corresponding to 0.8-6 LD50 in the atropinized guinea pig. The model differentiates between the summated highly toxic C(+/-)P(-)-soman stereoisomers at supralethal doses and the individual nontoxic C(+/-)P(+)-isomers. Several toxicant-specific parameters for the soman stereoisomers were measured in guinea pig tissue homogenates. Cardiac output and blood flow distribution were measured in the atropinized, anesthetized, and artificially ventilated guinea pig. The model was validated by comparison of the time courses for the blood concentrations of the two pairs of stereoisomers in the guinea pig after i.v. bolus administration with the blood concentrations predicted by the model. The predictions put forward for the summated C(+/-)P(-)-isomers are in reasonable agreement with the experimental data obtained after doses corresponding to 2 and 6 LD50. In view of large differences in the rates of hydrolysis of the C(+/-)P(+)isomers, these two isomers had to be differentiated for satisfactory modeling of both isomers. In order to model the toxicokinetics of C(+/-)P(-)-soman at a dose of 0.8 LD50, the almost instantaneous elimination of the C(+/-)P(-)-isomer at that dose had to be taken into account. The sensitivity of the predictions of the model to variations in the parameters has been studied with incremental sensitivity analysis. The results of this analysis indicate that extension to a model involving four individual stereoisomers is desirable in view of large differences in the biochemical characteristics of the two C(+/-)P(-)- and C(+/-)P(+)-isomers. C1 DAKKRO CORP,DENVER,CO 80222. USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. RP Langenberg, JP (reprint author), TNO,PRINS MAURITS LAB,POB 45,NL-2280 AA RIJSWIJK,NETHERLANDS. NR 41 TC 24 Z9 24 U1 0 U2 4 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-5761 J9 ARCH TOXICOL JI Arch. Toxicol. PD MAR PY 1997 VL 71 IS 5 BP 320 EP 331 DI 10.1007/s002040050393 PG 12 WC Toxicology SC Toxicology GA WW097 UT WOS:A1997WW09700007 PM 9137811 ER PT J AU Segal, DR Tiggle, RB AF Segal, DR Tiggle, RB TI Attitudes of citizen-soldiers toward military missions in the post-Cold War world SO ARMED FORCES & SOCIETY LA English DT Article; Proceedings Paper CT 1995 Biennial Meeting of the Inter-University Seminar on Armed Forces and Society CY OCT 20-22, 1995 CL BALTIMORE, MD ID PEACEKEEPERS; SINAI AB The 28th six-month rotation of peacekeepers to the Sinai Multinational force and Observers (MFO) was an experiment to test the use of a composite farce of reserve and active component soldiers for peacekeeping. This article presents analyses of the attitudes of reserve soldiers who volunteered for this mission, based on three waves of surveys conducted before and during the deployment. We focus on three sets of attitudes that bear on the way citizen-soldiers are Likely to play the role of peacekeeper: perceptions of the likelihood of American forces being deployed for a range of missions over the next decade; attitudes toward foreigners and foreign experiences that might affect adjustment to multinational military environments; and attitudes toward the peacekeeping role. Like earlier active duty soldiers who have served in the Sinai MFO, our respondents regarded operations other than war to be considerably more likely than high intensity warfare in the future. However, their estimates of the likelihood of American involvement in actual hostilities was higher toward the end of the deployment than prior to the deployment. We did not find an emergence of a transcultural orientation among the soldiers. Most of them did not regard foreign nationals as trustworthy, and disagreed with the idea that people are pretty much alike across national boundaries. An increased number of soldiers seem to have been motivated to volunteer more by a desire for travel and new experiences than by a desire to work with and among people of other nationalities. The analysis of soldiers' attitudes toward various components of the peacekeeping mission showed a considerable degree of change. Although a majority of soldiers supported the basic peacekeeping norms of minimal use of force and reduction of conflict, the size of the majority decreased through the mission, and a strong majority denied that peacekeeping could be performed by unarmed personnel. C1 USA,RES INST BEHAV & SOCIAL SCI,ORG & PERSONNEL RESOURCES RES UNIT,WASHINGTON,DC 20310. RP Segal, DR (reprint author), UNIV MARYLAND,DEPT SOCIOL,CTR RES MIL ORG,COLLEGE PK,MD 20742, USA. NR 23 TC 21 Z9 21 U1 0 U2 1 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SPR PY 1997 VL 23 IS 3 BP 373 EP & DI 10.1177/0095327X9702300304 PG 19 WC Political Science; Sociology SC Government & Law; Sociology GA XA902 UT WOS:A1997XA90200004 ER PT J AU Lakhani, H Abod, ET AF Lakhani, H Abod, ET TI The effectiveness of economic incentives for career commitment of peacekeepers in the Sinai SO ARMED FORCES & SOCIETY LA English DT Article; Proceedings Paper CT 1995 Biennial Meeting of the Inter-University Seminar on Armed Forces and Society CY OCT 20-22, 1995 CL BALTIMORE, MD AB This paper has two objectives. The first objective is to estimate the extent of financial gains or losses of Active Component (AC) and Reserve Component (RC) soldiers who volunteered for the Multinational Force and Observers (MFO) peacekeeping mission in the Sinai. The second objective is to estimate the effect of this gain/loss on the soldiers' intention to remain in their respective component until retirement. Data for a population of approximately 500 volunteers were collected during their predeployment training and Sind deployment phases. Results of these data revealed that, overall, soldiers experienced financial gains during the deployment phase. The average financial gain exceeded the average loss. Financial gains were especially high for the RC. Regression results for the deployment phase data revealed that the volunteers were more likely to say that they intend to stay in their respective component until retirement if they made financial gains during deployment and if they were satisfied with Army life. Results of the Chow Test for equality of regression parameters showed that the coefficients in separate equations for the AC and RC were not significantly different during the more critical deployment phase. Implications of these results are discussed. RP Lakhani, H (reprint author), USA,RES INST BEHAV & SOCIAL SCI,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 32 TC 2 Z9 2 U1 1 U2 2 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SPR PY 1997 VL 23 IS 3 BP 391 EP & DI 10.1177/0095327X9702300305 PG 25 WC Political Science; Sociology SC Government & Law; Sociology GA XA902 UT WOS:A1997XA90200005 ER PT J AU Nappo, CJ Bach, WD AF Nappo, CJ Bach, WD TI Summary report on the ARO/ARL workshop on turbulence and diffusion in the stable planetary boundary layer SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Editorial Material AB A workshop on turbulence and diffusion in the stable planetary boundary layer (SPBL) was held on 11-13 January 1994 at Arizona State University, Tempe, Arizona. Topics discussed included the interactions of gravity waves with turbulence, observations and data analysis in the SPBL, laboratory experiments in stably stratified fluids, and atmospheric dispersion in the SPBL. This report summaries the presentations and discussions made during the workshop and lists the recommendations made for further research. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Nappo, CJ (reprint author), NOAA,ENVIRONM RES LABS,ATMOSPHER TURBULENCE & DIFFUS DIV,AIR RESOURCES LAB,POB 2456,OAK RIDGE,TN 37831, USA. NR 0 TC 6 Z9 6 U1 1 U2 1 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0003-0007 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD MAR PY 1997 VL 78 IS 3 BP 493 EP 498 PG 6 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA WW304 UT WOS:A1997WW30400012 ER PT J AU Bauer, JJ Connelly, RR Sesterhenn, IA Bettencourt, MC McLeod, DG Srivastava, S Moul, JW AF Bauer, JJ Connelly, RR Sesterhenn, IA Bettencourt, MC McLeod, DG Srivastava, S Moul, JW TI Biostatistical modeling using traditional variables and genetic biomarkers for predicting the risk of prostate carcinoma recurrence after radical prostatectomy SO CANCER LA English DT Article DE prostate carcinoma; prostatectomy; recurrence; p53; bcl-2; Ki-67 ID CLINICAL STAGE; GLEASON SCORE; CANCER; ANTIGEN; PROGRESSION; MEN; DIAGNOSIS; TIME AB BACKGROUND. Approximately 50-60% of patients treated with radical prostatectomy for clinically localized prostate carcinoma are found to have microscopic disease that is not organ-confined, and a significant portion of these patients will relapse. Multiple studies have attempted to identify these high risk patients by evaluating many potential prognostic variables. These studies, however, have not included the more recent molecular biomarkers found to be independent predictors of disease recurrence. METHODS. One hundred thirty-two patients who underwent radical prostatectomy at one center between 1986 and 1993 were subjected to a multivariable Cox regression analysis to determine the preoperative and postoperative variables that remain significant predictors for the likelihood of serologic recurrence. The preoperative variables included in the model were age, race, and prostate specific antigen(PSA); the postoperative variables were Gleason sum, nuclear grade, pathologic stage (capsular status), p53 tumor suppressor gene expression, bcl-2 protooncogene expression, and proliferative biomarker Ki-67 expression. Biomarkers were also evaluated separately. RESULTS. A model tvas developed using only variables that remained significant predictors for the likelihood of recurrence. The following equation calculated the relative risk of recurrence: R(w) = exp [(0.70 x Race) + (0.79 x PSA{4.1-10}) + (1.34 x PSA{>10}) + (0.91 x Organ confinement) + (0.65 x p53{1,2+}) + (1.45 x p53{3,4+}) + (0.70 x bcl-2)]. This equation categorized men into 3 distinct risk groups (low: R(r) < 5.0; intermediate: R(r) = 5.0-15.0; high risk: R(r) > 15.0). CONCLUSIONS. This equation allows patients at high risk for PSA recurrence to be identified shortly after radical surgery. These patients at high risk for serologic recurrence and eventual progression may be considered for currently accepted adjuvant therapy or enrollment in clinical trials for the newer investigational therapies for locally advanced prostate carcinoma. (C) 1997 American Cancer Society. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTATE DIS RES,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT GENITOURINARY MED,WASHINGTON,DC 20306. NR 29 TC 59 Z9 59 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD MAR 1 PY 1997 VL 79 IS 5 BP 952 EP 962 DI 10.1002/(SICI)1097-0142(19970301)79:5<952::AID-CNCR12>3.0.CO;2-1 PG 11 WC Oncology SC Oncology GA WJ667 UT WOS:A1997WJ66700012 PM 9041158 ER PT J AU Gross, CL Giles, KC Smith, WJ AF Gross, CL Giles, KC Smith, WJ TI L-oxothiazolidine 4-carboxylate pretreatment of isolated human peripheral blood lymphocytes reduces sulfur mustard cytotoxicity SO CELL BIOLOGY AND TOXICOLOGY LA English DT Article DE cytotoxicity; glutathione; human lymphocytes; sulfur mustard ID URINARY METABOLITES; GLUTATHIONE LEVELS; HUMAN-CELLS; L-2-OXOTHIAZOLIDINE-4-CARBOXYLATE; TOXICITY; ELEVATION; TRANSPORT; PROTECTS; ESTER; ACID AB Sulfur mustard (HD, mustard gas) is a vesicant chemical warfare agent for which there is no specific medical countermeasure. A potential approach to combating the debilitating effects of this agent is the use of compounds that can react with this material before it interacts with critical macromolecules. Glutathione (GSH), a tripeptide that exists in high concentrations in cells, reacts with HD and is involved in HD detoxification. Pretreatment of human peripheral blood lymphocytes (PBL) with 10 mmol/L L-oxothiazolidine-4-carboxylate (OTC), a ''masked'' cysteine precursor, increased intracellular glutathione levels 25-50% over control values. Pretreated PBL were harvested, washed, and exposed to 10, 50, or 100 mu mol/L HD. Flow cytometry was used to measure cytotoxicity by propidium iodide uptake. Pretreatment of PBL with OTC led to small decreases in cytotoxicity after HD exposure. However, treatment of cells with OTC after HD exposure was not beneficial. Compounds that can modulate GSH levels within the cell may help to reduce the cytotoxicity of HD when used as a pretreatment. RP Gross, CL (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,MCMR UV PB,ABERDEEN PROVING GROUND,MD 21010, USA. NR 23 TC 14 Z9 17 U1 0 U2 5 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0742-2091 J9 CELL BIOL TOXICOL JI Cell Biol. Toxicol. PD MAR PY 1997 VL 13 IS 3 BP 167 EP 173 DI 10.1023/A:1007354127919 PG 7 WC Cell Biology; Toxicology SC Cell Biology; Toxicology GA WP261 UT WOS:A1997WP26100003 PM 9088626 ER PT J AU Schrock, ME Barrows, ES Rosman, LB AF Schrock, ME Barrows, ES Rosman, LB TI Biota-to-sediment accumulation factors for TCDD and TCDF in worms from 28-day bioaccumulation tests SO CHEMOSPHERE LA English DT Article; Proceedings Paper CT 15th International Symposium on Chlorinated Dioxins, PCB and Related Compounds CY AUG 21-25, 1995 CL EDMONTON, CANADA DE TCDD; TCDF; bioaccumulation; sediment; biota-to-sediment accumulation factor ID CONTAMINANTS AB Sediments from waterbodies near highly urbanized, industrial areas were analyzed for 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran (TCDD/TCDF) contamination. Using a dredged material evaluation test, Nereis virens worms were exposed to the contaminated sediment for 28 days and then analyzed for TCDD/TCDF to evaluate the potential bioaccumulation of these contaminants. Levels of TCDD/TCDF in N. virens increased as sediment contamination increased. Average TCDD/TCDF biota-to-sediment accumulation factors (BSAF) based on the tissue TCDD/TCDF concentration, tissue lipid content, sediment TCDD/TCDF concentration, and sediment total organic carbon (TOC) from nine sites with varying dioxin contamination were calculated. These average BSAFs were used to predict the uptake of TCDD/TCDF in N. virens exposed to sediments from a tenth site. (C) 1997 Elsevier Science Ltd. C1 BATTELLE MARINE SCI LAB,SEQUIM,WA 98382. USA CORPS ENGINEERS,NEW YORK,NY 10278. RP Schrock, ME (reprint author), BATTELLE MEM INST,505 KING AVE,COLUMBUS,OH 43201, USA. NR 7 TC 11 Z9 11 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD MAR-APR PY 1997 VL 34 IS 5-7 BP 1333 EP 1339 DI 10.1016/S0045-6535(97)00430-X PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA WR677 UT WOS:A1997WR67700036 ER PT J AU Torrington, CKG Shorr, AF Parker, MJW AF Torrington, CKG Shorr, AF Parker, MJW TI Endobronchial disease and racial differences in pulmonary sarcoidosis SO CHEST LA English DT Article DE African-Americans; endobronchial biopsy; fiberoptic bronchoscopy; racial differences; sarcoidosis; transbronchial lung biopsy; white Americans ID TRANSBRONCHIAL LUNG-BIOPSY; BRONCHOALVEOLAR LAVAGE; OPTIMAL NUMBER; DIAGNOSIS AB In a retrospective review of 7 years of Walter Reed Army Medical Center fiberoptic bronchoscopy records, 154 patients with biopsy specimen proved (122) and clinically diagnosed (32) sarcoidosis were identified. Endobronchial mucosal appearance was normal in only 70 (45%). Abnormal mucosal findings included erythema (29 patients), nodules (13), plaques (13), and cobblestoning (29). Fifty-nine patients were evaluated with endobronchial biopsies (EBBX), and non-necrotizing granulomata diagnostic of sarcoidosis were found in 42 (71%). The diagnostic yield from endobronchial biopsies was similar regardless of the type of mucosal abnormality. EBBX specimens were diagnostic in 85% of black patients and 38% of white patients (p=0.00081), but diagnostic yield did not correlate with patient's sex, symptoms, radiographic stage of disease, or extent of physiologic abnormalities. Four patients with normal-appearing bronchial mucosa underwent EBBX, and sarcoidosis was diagnosed in two. Transbronchial lung biopsy (TBBX) specimens were diagnostic of sarcoidosis in 61 of 82 (74%) black and 28 of 56 (50%) white patients (p=0.0038). We conclude that the bronchial mucosa appears abnormal in the majority (55%) of patients with sarcoidosis. EBBX specimens will diagnose sarcoidosis in a high percentage of such patients and should be performed routinely. EBBX may be preferable to TBBX because of its greater safety profile. In our patients, the yield of both EBBX and TBBX was significantly greater in African-Americans than white Americans. RP Torrington, CKG (reprint author), WALTER REED ARMY MED CTR, PULM & CRIT CARE MED SERV, WASHINGTON, DC 20307 USA. NR 17 TC 9 Z9 9 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD MAR PY 1997 VL 111 IS 3 BP 619 EP 622 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA WM946 UT WOS:A1997WM94600018 ER PT J AU Toney, MO Williams, S AF Toney, MO Williams, S TI Focal TI-201 uptake in pneumonia SO CLINICAL NUCLEAR MEDICINE LA English DT Article ID LUNG UPTAKE; DIFFUSE RP Toney, MO (reprint author), BROOKE ARMY MED CTR,DEPT RADIOL,SAN ANTONIO,TX 78234, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD MAR PY 1997 VL 22 IS 3 BP 183 EP 184 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA WL921 UT WOS:A1997WL92100012 PM 9067676 ER PT J AU Jacob, E Cierny, G Zorn, K McNeill, JF Fallon, MT AF Jacob, E Cierny, G Zorn, K McNeill, JF Fallon, MT TI Delayed local treatment of rabbit tibial fractures with biodegradable cefazolin microspheres SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID DRUG DELIVERY; BONE-CEMENT; INFECTION; OSTEOMYELITIS; PREVENTION; BEADS; MANAGEMENT; SYSTEM AB The prevention of infection is a primary objective in the treatment of open fractures, The objective of this study was to compare the efficacy of biodegradable, poly (DL-lactide-co-glycolide) cefazolin microspheres and free cefazolin powder in Staphylococcus aureus contaminated rabbit tibial fractures when treatment was delayed for 2 hours, Fractures were produced in the tibia of rabbits, inoculated with Staphylococcus aureus, and 2 hours later treated by either direct local application of cefazolin microspheres or an equivalent dose of free cefazolin powder, Control animals did not receive antibiotic therapy, The fractures then were stabilized with a bone plate, and the animals were observed for 8 weeks, Local antibiotic therapy with biodegradable cefazolin microspheres prevented the establishment of infection in all animals, and cultures of the tibiae were sterile in all cases, In contrast, clinical evidence of infection developed in 50% of the rabbits that had been treated with free cefazolin powder and 71% of the control animals, Staphylococcus aureus was recovered from the tibiae of 75% and 100% of these animals, respectively, The results of this study suggest that local antibiotic therapy with biodegradable, controlled release cefazolin microspheres may be useful for the management of open fractures in humans, even when treatment is delayed for several hours after bacterial contamination. C1 ST JOSEPHS HOSP,ATLANTA,GA. VET ADM MED CTR,DECATUR,GA. EMORY UNIV,SCH MED,DEPT PATHOL & LAB MED,ATLANTA,GA 30322. RP Jacob, E (reprint author), USA,WALTER REED ARMY INST RES,WALTER REED ARMY MED CTR,DENT RES DETACHMENT,BLDG 40,WASHINGTON,DC 20307, USA. NR 40 TC 14 Z9 14 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD MAR PY 1997 IS 336 BP 278 EP 285 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA WL834 UT WOS:A1997WL83400036 PM 9060514 ER PT J AU Gruber, C AF Gruber, C TI Projective identification or relational introjection? Gender, metaphor, and theory SO CLINICAL SOCIAL WORK JOURNAL LA English DT Article; Proceedings Paper CT 5th National Conference of the National-Membership-Committee-on-Psychoanalysis-in-Clinical-Social-Work CY OCT 28, 1995 CL NEW YORK, NY SP Natl Membership Comm Psychoanal Clin Social Work DE projective identification; self-in-relation; metaphor; gender AB This paper explores how gender determined metaphors may influence theoretical constructs. It provides a historical review of how the deconstruction of male metaphors has influenced changes in drive and structural theories and examines the influence of male metaphors on object relations theory. Specifically, the construct of projective identification is explored in relation to inconsistencies in how it is conceptualized and how it is a construct more in keeping with a male model of development. The self-in-relation model of female development is explored in order to offer an alternative construction of similar clinical phenomena. Through a feminine metaphoric lens these phenomena could be seen as relational introjections. The latter conceptualization is also supported by early infant research and current literature on intersubjectivity in the therapeutic process. A case vignette is used to illustrate how a particular piece of therapeutic work could be conceptualized as either projective identification or relational introjection. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. VIRGINIA COMMONWEALTH UNIV,SCH SOCIAL WORK,RICHMOND,VA 23284. NR 24 TC 0 Z9 0 U1 0 U2 0 PU HUMAN SCI PRESS INC PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013-1578 SN 0091-1674 J9 CLIN SOC WORK J JI Clin. Soc. Work J. PD SPR PY 1997 VL 25 IS 1 BP 59 EP 70 DI 10.1023/A:1025781810698 PG 12 WC Social Work SC Social Work GA WR514 UT WOS:A1997WR51400007 ER PT J AU Koh, G AF Koh, G TI Complex dielectric constant of ice at 1.8 GHz SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article DE dielectric constant; ice; microwave methods AB The complex dielectric constant of bubble-free ice grown from deionized water was determined at 1.8 GHz using an interference technique. The interference pattern was produced by measuring the reflected signals from bubble-free ice slabs of varying thickness at normal incident anole. The wavelength and loss factor in the bubble-free ice samples were obtained from the resulting interference pattern. The real and imaginary components of the dielectric constant were determined to be 3.17 and 0.003, respectively. RP Koh, G (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 7 TC 1 Z9 1 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD MAR PY 1997 VL 25 IS 2 BP 119 EP 121 DI 10.1016/S0165-232X(96)00021-3 PG 3 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA WN566 UT WOS:A1997WN56600004 ER PT J AU Schoening, J Wheeler, T AF Schoening, J Wheeler, T TI Standards - The key to education reform SO COMPUTER LA English DT Article RP Schoening, J (reprint author), USA,COMMUN ELECT COMMAND,PERSONAL LEARNING SYST INITIAT,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 SN 0018-9162 J9 COMPUTER JI Computer PD MAR PY 1997 VL 30 IS 3 BP 116 EP 117 DI 10.1109/MC.1997.573680 PG 2 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA WL492 UT WOS:A1997WL49200030 ER PT J AU Wang, D Chowdhury, MR Haldar, A AF Wang, D Chowdhury, MR Haldar, A TI System reliability evaluation considering strength and serviceability requirements SO COMPUTERS & STRUCTURES LA English DT Article AB A robust system reliability evaluation method is proposed for aging redundant structures. Pile-supported structures commonly used for darns are specifically addressed. The individual pile behavior is considered to be brittle-type and the group behavior is considered to be parallel-type. Both strength and serviceability performance modes are considered. Using the advanced first-order second-moment reliability method, the element-level reliability indices are calculated for individual piles for several strength limit states. The system-level reliability indices of the pile group are calculated considering the lateral and vertical deflection limit states. Using the performance mode approach, which is referred to as the failure mode approach in the literature, a procedure is proposed to identify significant performance modes of the system by combining the element-level and system-level reliabilities. The bounds of the system reliability are then estimated. The procedure is first verified using information from load tests. The method is then applied to estimate the bounds of system reliability for a pile-supported dam. Identification of the significant performance modes becomes easier using the proposed method. It is observed that the values used for the allowable lateral and vertical deflections are critical in the overall system reliability evaluation. The lower and upper bounds of the system reliability are observed to be narrow for the examples considered in the study. The proposed procedure significantly improves the state of the art in the evaluation of system reliability of pile-supported structures. Copyright (C) 1996 Elsevier Science Ltd. C1 USA,ENGINEER WATERWAYS EXPT STN,STRUCT LAB,VICKSBURG,MS 39180. RP Wang, D (reprint author), UNIV ARIZONA,DEPT CIVIL ENGN & ENGN MECH,TUCSON,AZ 85721, USA. NR 14 TC 2 Z9 5 U1 2 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-7949 J9 COMPUT STRUCT JI Comput. Struct. PD MAR PY 1997 VL 62 IS 5 BP 883 EP 896 DI 10.1016/S0045-7949(96)00222-2 PG 14 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA WC982 UT WOS:A1997WC98200009 ER PT J AU Sprung, CL Eidelman, LA Pizov, R Fisher, CJ Ziegler, EJ Sadoff, JC Straube, RC McCloskey, RV AF Sprung, CL Eidelman, LA Pizov, R Fisher, CJ Ziegler, EJ Sadoff, JC Straube, RC McCloskey, RV TI Influence of alterations in forgoing life-sustaining treatment practices on a clinical sepsis trial SO CRITICAL CARE MEDICINE LA English DT Article DE sepsis; forgoing; withhold; withdraw; life-sustaining; treatments; trial; critical care; intensive care unit; mortality ID INTENSIVE-CARE UNIT; CRITICALLY ILL; DOUBLE-BLIND; MANAGEMENT; WITHDRAWAL; ANTIBODY; SUPPORT; PATIENT AB Objectives: To evaluate the timing of forgoing life sustaining treatments in patients enrolled in a sepsis trial and to determine their influence on patient outcome and trial results, Design: Subset of patients in a prospective, randomized, double-blind, placebo controlled study. Setting: Twenty-three academic medical centers. Patients. Enrolled patients who had life-sustaining therapies withheld or withdrawn. Measurements and Main Results: The number of patients, types of disorders and interventions, reasons, and timing of with-holding and withdrawing life-sustaining treatments and their effect on mortality and trial results were assessed. Forgoing of life-sustaining therapies took place in 117(22%) of 543 patients and occurred within 72 hrs of study drug administration in 38 (32%) patients, Withholding treatment (60%) was more common than withdrawing treatment (40%), but withdrawing treatment was more frequent (51%) than withholding treatment (20%) in the first 72 has of the trial (p <.01), Sixty-one (52%) patients had severe underlying disorders with a poor prognosis, The hospital mortality rate was 94% (of the 117 patients), The mean time (SEM) from withholding or withdrawing of treatment until death was 2.83 +/- 0.57 and 0.32 +/- 0.13 days, respectively (p <.001), Patients who had therapies forgone in the first 24, 48, and 72 hrs after receiving the study drug had higher mortality rates in the first 72 hrs (p <.01). Conclusions: A substantial number of patients enrolled in a sepsis trial had severe underlying diseases and had forgoing of therapies early in the course of the trial, which led to a higher early mortality rate, Enrollment of patients in clinical trials with severe underlying disorders with a high likelihood of having therapies forgone may bias the potential for showing the efficacy of new therapeutic modalities. C1 CLEVELAND CLIN FDN, DEPT PULM & CRIT CARE MED, CLEVELAND, OH 44195 USA. UNIV CALIF SAN DIEGO, DEPT MED, SAN DIEGO, CA 92103 USA. WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT BACTERIAL DIS, WASHINGTON, DC 20307 USA. T CELL SCI, CAMBRIDGE, MA USA. CENTOCOR INC, MALVERN, PA USA. RP Sprung, CL (reprint author), HEBREW UNIV JERUSALEM, HADASSAH MED CTR, DEPT ANESTHESIOL & CRIT CARE MED, POB 12000, IL-91120 JERUSALEM, ISRAEL. NR 18 TC 21 Z9 22 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD MAR PY 1997 VL 25 IS 3 BP 383 EP 387 DI 10.1097/00003246-199703000-00002 PG 5 WC Critical Care Medicine SC General & Internal Medicine GA WQ833 UT WOS:A1997WQ83300002 PM 9118650 ER PT J AU Cerco, CF Seitzinger, SP AF Cerco, CF Seitzinger, SP TI Measured and modeled effects of benthic algae on eutrophication in Indian River Rehoboth Bay, Delaware SO ESTUARIES LA English DT Article ID COASTAL LAGOON ECOSYSTEM; NUTRIENT FLUX; INORGANIC NITROGEN; CHESAPEAKE BAY; FRESH-WATER; SEDIMENT; OXYGEN; MICROPHYTOBENTHOS; COMMUNITY; DYNAMICS AB A combination of field studies and mathematical modeling was used to examine the role of subtidal benthic algae in the eutrophication processes in two shallow estuarine systems. Field measurements indicated uptake by benthic algae retained ammonium and phosphate in the sediments when light at the sediment surface exceeded approximate to 150 mu E m(-2) s(-1). The measurements were used to calibrate a newly developed model of benthic algal activity. The benthic algal model was coupled with a hydrodynamic model, a eutrophication model, and a sediment diagenesis model. In the simulated ecosystem, benthic algae had a major influence in the intra-annual cycling of nitrogen and phosphorus. When nutrients were abundant in the water column (late winter and spring) they were transferred to the sediments through algal activity. Diagenesis released these nutrients to the water column in summer when nutrients were scarce. As a result of the nutrient transfer, annual primary production in the water column, in the presence of benthic algae, exceeded production in the absence of the algae. C1 RUTGERS STATE UNIV,INST MARINE & COASTAL SCI,NOAA,CMER PROGRAM,NEW BRUNSWICK,NJ 08903. RP Cerco, CF (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 53 TC 56 Z9 60 U1 3 U2 9 PU ESTUARINE RES FEDERATION PI LAWRENCE PA PO BOX 368, LAWRENCE, KS 66044 SN 0160-8347 J9 ESTUARIES JI Estuaries PD MAR PY 1997 VL 20 IS 1 BP 231 EP 248 DI 10.2307/1352733 PG 18 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA WT784 UT WOS:A1997WT78400018 ER PT J AU Wolf, MK deHaan, LAM Cassels, FJ Willshaw, GA Warren, R Boedeker, EC Gaastra, W AF Wolf, MK deHaan, LAM Cassels, FJ Willshaw, GA Warren, R Boedeker, EC Gaastra, W TI The CS6 colonization factor of human enterotoxigenic Escherichia coli contains two heterologous major subunits SO FEMS MICROBIOLOGY LETTERS LA English DT Article DE colonization factor; Escherichia coli; enterotoxigenic Escherichia coli ID EXPRESSION; ANTIGEN; GENES; BACTERIA; PCF8775; OPERON AB The genes encoding the CS6 colonization factor were cloned from two human enterotoxigenic Escherichia coli strains of different serotypes. The DNA sequences from both clones were nearly identical and contained four open reading frames. Two of them have homology to genes encoding molecular chaperones and ushers found in many other operons encoding colonization factors. The two remaining open reading frames encode two heterologous major subunit proteins which makes CS6 unique because other colonization factors have only one major subunit. Upstream and downstream of the CS6 operon the DNA sequences of the clones diverged abruptly. C1 UNIV UTRECHT, DEPT IMMUNOL & INFECT DIS, UTRECHT, NETHERLANDS. CENT PUBL HLTH LAB, DIV ENTER PATHOGENS, LONDON NW9 5HT, ENGLAND. WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT BACTERIAL DIS, WASHINGTON, DC 20307 USA. RP Wolf, MK (reprint author), WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT GASTROENTEROL, WASHINGTON, DC 20307 USA. NR 24 TC 46 Z9 46 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0378-1097 EI 1574-6968 J9 FEMS MICROBIOL LETT JI FEMS Microbiol. Lett. PD MAR 1 PY 1997 VL 148 IS 1 BP 35 EP 42 DI 10.1016/S0378-1097(97)00009-8 PG 8 WC Microbiology SC Microbiology GA WL537 UT WOS:A1997WL53700006 PM 9066107 ER PT J AU Meiselman, HL MacFie, HJ AF Meiselman, HL MacFie, HJ TI Untitled SO FOOD QUALITY AND PREFERENCE LA English DT Editorial Material C1 FOOD RES INST,DEPT CONSUMER SCI & DEPUTY,READING RG6 6BZ,BERKS,ENGLAND. FOOD RES INST,READING LAB,READING RG6 6BZ,BERKS,ENGLAND. RP Meiselman, HL (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0950-3293 J9 FOOD QUAL PREFER JI Food. Qual. Prefer. PD MAR PY 1997 VL 8 IS 2 BP 83 EP 83 DI 10.1016/S0950-3293(97)85707-2 PG 1 WC Food Science & Technology SC Food Science & Technology GA WK986 UT WOS:A1997WK98600001 ER PT J AU Tuorila, H Kramer, FM Cardello, AV AF Tuorila, H Kramer, FM Cardello, AV TI Role of attitudes, dietary restraint, and fat avoidance strategies in reported consumption of selected fat-free foods SO FOOD QUALITY AND PREFERENCE LA English DT Article ID 3-FACTOR EATING QUESTIONNAIRE; RELIABILITY; BEHAVIOR; SALT AB The roles of attitudes, dietary restraint, and fat avoidance strategies in past (reported) and future (forecast) consumption of fat-free foods (represented by pound cake, saltine crackers, and processed American cheese) were studied among 116 adult American subjects using correlational and multiple regression approaches. The predictive power was highest when the Predictors were specific to the action, i.e. directly related to the consumption of fat or fat-free products, but also the cognitive dimension of restrained eating was related to the consumption of fat-free foods. Both the past and the future consumption were best predicted by two composite scales, one related to the pleasantness of eating fat-free foods and the other on the acquired tendency to substitute low-fat products for high-fat alternatives. (C) 1997 Elsevier Science Ltd. C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RP Tuorila, H (reprint author), UNIV HELSINKI,DEPT FOOD TECHNOL,FIN-00014 HELSINKI,FINLAND. NR 19 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0950-3293 J9 FOOD QUAL PREFER JI Food. Qual. Prefer. PD MAR PY 1997 VL 8 IS 2 BP 119 EP 123 DI 10.1016/S0950-3293(96)00034-1 PG 5 WC Food Science & Technology SC Food Science & Technology GA WK986 UT WOS:A1997WK98600006 ER PT J AU Perovich, DK Elder, BC RichterMenge, JA AF Perovich, DK Elder, BC RichterMenge, JA TI Observations of the annual cycle of sea ice temperature and mass balance SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID HEAT-FLUX; OCEAN; MODEL AB A vertical array of thermistors coupled with an autonomous data-logging system was used to obtain a 15-month record of ice temperature profiles in a multiyear flee in the Beaufort Sea. This record was used to monitor atmosphere, ice and ocean temperatures, determine changes in the ice mass balance, and infer estimates of the ocean heat flux and the snow thermal conductivity. Ablation during the summer melt season consisted of approximately 0.3 m of snow melt, 0.67 m of ice surface ablation and 0.25 m of bottom ablation. There was 0.45 m of bottom accretion during the growth season. The annually averaged ocean heat flux was 4 W m(-2), with a summertime value of 9 W m(-2). Comparing these results to earlier studies conducted in the same region showed considerable interannual variability in summer melting. The thermal conductivity of snow cover was approximately 0.3 W m(-1) K-1 during winter. RP Perovich, DK (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 14 TC 21 Z9 22 U1 0 U2 1 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD MAR 1 PY 1997 VL 24 IS 5 BP 555 EP 558 DI 10.1029/97GL00185 PG 4 WC Geosciences, Multidisciplinary SC Geology GA WL742 UT WOS:A1997WL74200016 ER PT J AU Hesler, LS Hammack, L AF Hesler, LS Hammack, L TI Sex-related color patterns in elytral vittae of Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae) SO GREAT LAKES ENTOMOLOGIST LA English DT Article ID ROOTWORM BEETLES COLEOPTERA; CORN AB We evaluated the color patterns of elytral vittae by sex in adults of Diabrotica virgifera virgifera LeConte. Our study examined >1000 beetles taken from a field population, a laboratory colony, and a reference collection containing 712 specimens from 15 of the United States and from the province of Ontario, Canada. The humeral and sutural vittae of each beetle's elytra were classified as being separate, partially confluent, or totally confluent with each other. The distribution of these elytral patterns was not independent of sex. Males tended to have confluent or partially confluent vittae, whereas females largely had separate vittae. Nonetheless, all three patterns of elytral vittae were found in both sexes of D. v. virgifera, and many beetles of each sex had partially confluent vittae. This data shows that sexing D. v. virgifera beetles by simple examination of elytral vittae alone is unreliable. RP Hesler, LS (reprint author), USA,MED DEPT CTR & SCH,MED ZOOL BRANCH,MCCS HPM,3151 SCOTT RD,FT SAM HOUSTON,TX 78234, USA. NR 14 TC 1 Z9 1 U1 0 U2 1 PU MICH ENTOMOL SOC PI E LANSING PA MICH STATE UNIV DEPT ENTOMOL, E LANSING, MI 48823 SN 0090-0222 J9 GREAT LAKES ENTOMOL JI Gt. Lakes Entomol. PD SPR-SUM PY 1997 VL 30 IS 1-2 BP 45 EP 50 PG 6 WC Entomology SC Entomology GA YF499 UT WOS:A1997YF49900004 ER PT J AU Echevarria, AJ AF Echevarria, AJ TI Heroic history and vicarious war: Nineteenth-century German military history writing SO HISTORIAN LA English DT Article RP Echevarria, AJ (reprint author), USA,TRAINING & DOCTINE COMMAND,FUTURE BATTLE DIRECTORATE,WASHINGTON,DC 20310, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU PHI ALPHA THETA PI ALLENTOWN PA THE HISTORIAN 50 COLLEGE DR, ALLENTOWN, PA 18104-6100 SN 0018-2370 J9 HISTORIAN JI Historian PD SPR PY 1997 VL 59 IS 3 BP 573 EP 589 DI 10.1111/j.1540-6563.1997.tb01006.x PG 17 WC History SC History GA XF520 UT WOS:A1997XF52000006 ER PT J AU King, CS AF King, CS TI The Albanians: A modern history - Vickers,M SO HISTORIAN LA English DT Book Review RP King, CS (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU PHI ALPHA THETA PI ALLENTOWN PA THE HISTORIAN 50 COLLEGE DR, ALLENTOWN, PA 18104-6100 SN 0018-2370 J9 HISTORIAN JI Historian PD SPR PY 1997 VL 59 IS 3 BP 712 EP 713 PG 2 WC History SC History GA XF520 UT WOS:A1997XF52000075 ER PT J AU Neudeck, PG Fazi, C AF Neudeck, PG Fazi, C TI Positive temperature coefficient of breakdown voltage in 4H-SiC PN junction rectifiers SO IEEE ELECTRON DEVICE LETTERS LA English DT Article ID FILMS; DEVICES; SI AB It has been suggested that once silicon carbide (SIG) technology overcomes some crystal growth obstacles, superior SIC semiconductor devices would supplant silicon in many high-power applications. However, the property of positive temperature coefficient of breakdown voltage, a behavior crucial to realizing excellent power device reliability, has not been observed in 4H-SiC, which is presently the best-suited SiC polytype for power device implementation. This paper reports the first experimental measurements of stable positive temperature coefficient behavior observed in 4H-SiC pn junction rectifiers. This research indicates that robust 4H-SiC power devices with high breakdown reliability should be achievable after SIC foundries reduce material defects such as micropipes, dislocations, and deep level impurities. C1 USA,RES LAB,ADELPHI,MD 20783. RP Neudeck, PG (reprint author), NASA,LEWIS RES CTR,CLEVELAND,OH 44135, USA. NR 17 TC 47 Z9 47 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD MAR PY 1997 VL 18 IS 3 BP 96 EP 98 DI 10.1109/55.556092 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA WJ197 UT WOS:A1997WJ19700006 ER PT J AU Arcone, SA Yankielun, NE Chacho, EF AF Arcone, SA Yankielun, NE Chacho, EF TI Reflection profiling of arctic lake ice using microwave FM-CW radar SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article ID SHORT-PULSE RADAR; SNOW; UHF AB X- and C-band FM-CW radar reflection profiles were obtained across frozen lakes in northern Alaska using a single elevated high-gain antenna. Clear returns were obtained from the air/snow, snow/ice, ice/water, and ice/ground interfaces. Surface-to-bottom signal intensity ratios are within ranges predicted by plane wave reflection theory, use of which also gives plausible permittivity values for the ice rich bottom silts. Scattering losses are interpreted for the X-band ice-bottom signals, but evidence of increased volumetric scattering loss with increasing ice thickness may have been masked by changes in bottom dielectric contrasts. The results suggest that this type of radar is superior to conventional transient GPR systems for this application and ice grounded to almost any type of bottom sediments could be profiled from an airborne platform. Such a system could help inventory wetland water volume in northern regions. RP Arcone, SA (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 24 TC 11 Z9 11 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD MAR PY 1997 VL 35 IS 2 BP 436 EP 443 DI 10.1109/36.563282 PG 8 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA WN531 UT WOS:A1997WN53100023 ER PT J AU Smits, JG Choi, WS Ballato, A AF Smits, JG Choi, WS Ballato, A TI Resonance and antiresonance of symmetric and asymmetric cantilevered piezoelectric flexors SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID PI-FET ACCELEROMETER; CONSTITUENT EQUATIONS; BIMORPHS; DEFLECTION AB The resonances of dynamically excited symmetric piezoelectric bimorphs have been determined from the equations of state. Under the effect of sinusoidal stimuli: a moment exerted at the tip M, a force exerted perpendicular to the plane of the bimorph also applied at the tip F, a uniformly applied pressure p, and an electrode voltage V, they respond with a sinusoidal tip rotation alpha, tip deflection delta, volume displacement nu, and electrode charge Q. All of the former are related to all of the latter through a dynamic admittance matrix B. The antiresonance frequency of the capacitance C have been found while also antiresonance in off-diagonal elements have been determined. The latter indicate that at these frequencies the bimorph does not work as an actuator or sensor in the particular domain of the off-diagonal. The mode shape at these antiresonance frequencies has been determined. The anitiresonsance of b(14) determines that for this frequency the tip has deflection but no rotation, while the antiresonance of b(24) indicates that the tip has rotation but no deflection. No antiresonance in the volume displacement is found, indicating that the bimorph is a pressure converter (microphone) at all frequencies. Micromachined piezoelectric heterogeneous bimorphs have been fabricated using the techniques of I.C. fabrication. Their deflections have been measured as a function of frequency and applied voltage, while these have been compared with the theoretical predictions. An anomalously large quadratic deflection has been found, superimposed on the linear piezloelectric behavior. The agreement between the linear part of the experimental deflection and the theory was quite good. C1 ALLIED SIGNAL INC,INSTRUMENT SYST,REDMOND,WA 98078. USA,RES LAB,ELECT & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. RP Smits, JG (reprint author), BOSTON UNIV,DEPT ELECT ENGN,BOSTON,MA 02215, USA. NR 22 TC 31 Z9 31 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD MAR PY 1997 VL 44 IS 2 BP 250 EP 258 DI 10.1109/58.585110 PG 9 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA WR981 UT WOS:A1997WR98100002 PM 18244123 ER PT J AU Kumar, A Kang, YH Gowda, K Mullen, CA Gordon, DM Kumar, S Hoffman, SL AF Kumar, A Kang, YH Gowda, K Mullen, CA Gordon, DM Kumar, S Hoffman, SL TI Autologous lymphoblastoid cell lines stably transfected with Plasmodium falciparum circumsporozoite protein as targets in cytotoxic T-lymphocyte assays SO IMMUNOLOGY LETTERS LA English DT Article DE malaria; Plasmodium falciparum; circumsporozoite protein; transfection; cytotoxic T-lymphocyte ID SPOROZOITE SURFACE PROTEIN-2; MALARIA; RESPONSES; EPITOPES; VOLUNTEERS; VACCINE AB To produce cell lines that can be used as a continuous source of antigen presenting cells for stimulating T-celI lines and clones and as targets in cytotoxic T-lymphocyte (CTL) assays, we used a retroviral vector with a simian virus (SV40) early promotor to transfer a Plasmodiumm falciparum circumsporozoite (PfCSP) gene into human EBV transformed B-lymphoblastoid cell lines (B-LCL). We herein report successful, stable transfection and cell surface expression of this gene, as confirmed by PCR, Western blot analysis and immunoelectron microscopy. One of three successfully transfected autologous cell lines expressed PfCSP on the cell surface and was lysed by CD8(+) T-cell dependent CTL from a donor volunteer who had been immunized with irradiated P. falciparum sporozoites. Such cell lines should provide excellent tools for characterizing human CD8(+) T-cell responses against Plasmadium sp. proteins. (C) 1997 Elsevier Science B.V. C1 NATL NAVAL MED CTR, DIV PATHOBIOL, BETHESDA, MD 20814 USA. UNIV TEXAS, DIV PEDIAT, HOUSTON, TX 77030 USA. WALTER REED ARMY INST RES, DIV COMMUNICABLE DIS & IMMUNOL, WASHINGTON, DC USA. NIAID, PARASIT DIS LAB, NIH, BETHESDA, MD 20892 USA. RP Kumar, A (reprint author), NATL NAVAL MED CTR, MALARIA PROGRAM, BETHESDA, MD 20814 USA. NR 19 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2478 J9 IMMUNOL LETT JI Immunol. Lett. PD MAR PY 1997 VL 55 IS 3 BP 183 EP 187 DI 10.1016/S0165-2478(97)02702-8 PG 5 WC Immunology SC Immunology GA WY161 UT WOS:A1997WY16100010 PM 9161886 ER PT J AU Devi, SJN Zollinger, WD Snoy, PJ Tai, JY Costantini, P Norelli, F Rappuoli, R Frasch, CE AF Devi, SJN Zollinger, WD Snoy, PJ Tai, JY Costantini, P Norelli, F Rappuoli, R Frasch, CE TI Preclinical evaluation of group B Neisseria meningitidis and Escherichia coli K92 capsular polysaccharide-protein conjugate vaccines in juvenile rhesus monkeys SO INFECTION AND IMMUNITY LA English DT Article ID INFLUENZAE TYPE-B; URINARY-TRACT INFECTION; POLYSIALIC ACID; MONOCLONAL-ANTIBODY; MENINGOCOCCAL POLYSACCHARIDE; K1; BRAIN; BINDING; IMMUNOGENICITY; ANTIGENS AB We reported the first use of group B meningococcal conjugate vaccines in a nonhuman primate model (S. J. N. Devi, C. E. Frasch, W. Zollinger, and P. J. Snoy, p. 427-429, in J. S. Evans, S. E. Yost, M. C. J. Maiden, and I. M. Feavers, ed., Proceedings of the Ninth International Pathogenic Neisseria Conference, 1994), Three different group B Neisseria meningitidis capsular polysaccharide (B PS)-protein conjugate vaccines and an Escherichia coli K92 capsular polysaccharide-tetanus toroid (K92-TT) conjugate vaccine are here evaluated for safety and relative immunogenicities in juvenile rhesus monkeys with or without adjuvants, Monkeys were immunized intramuscularly with either B PS-cross-reactive material 197 conjugate, B PS-outer membrane vesicle (B-OMV) conjugate, or N-propionylated B PS-outer membrane protein 3 (N-pr. B-OMP3) conjugate vaccine with or without adjuvants at weeks 0, 6, and 14. A control group of monkeys received one injection of the purified B PS alone, and another group received three injections of B PS noncovalently complexed,vith OMV. Antibody responses as measured by enzyme-linked immunosorbent assay varied among individual monkeys, All vaccines except B PS and the K92-TT conjugate elicited a twofold or greater increase in total B PS antibodies after one immunization, All vaccines, including the K92-TT conjugate, elicited a rise in geometric mean B PS antibody levels of ninefold or more over the preimmune levels following the third immunization. Antibodies elicited by N-pr. B-OMP3 and B-OMV conjugates were directed to the N-propionylated or to the spacer-containing B PS antigens as well as to the native B PS complexed with methylated human serum albumin, None of the vaccines caused discernible safety-related symptoms. C1 US FDA,DIV BACTERIAL PROD,OFF VACCINE RES & REVIEW,CTR BIOL EVALUAT & RES,ROCKVILLE,MD 20852. US FDA,DIV VET MED,CTR BIOL EVALUAT & RES,ROCKVILLE,MD 20852. WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. N AMER VACCINE INC,BELTSVILLE,MD 20705. CHIRON BIOCINE,I-53100 SIENA,ITALY. NR 46 TC 30 Z9 30 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAR PY 1997 VL 65 IS 3 BP 1045 EP 1052 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA WK953 UT WOS:A1997WK95300028 PM 9038314 ER PT J AU Zollinger, WD Moran, EE Devi, SJN Frasch, CE AF Zollinger, WD Moran, EE Devi, SJN Frasch, CE TI Bactericidal antibody responses of juvenile rhesus monkeys immunized with group B Neisseria meningitidis capsular polysaccharide-protein conjugate vaccines SO INFECTION AND IMMUNITY LA English DT Article ID ESCHERICHIA-COLI K1; INFLUENZAE TYPE-B; MONOCLONAL-ANTIBODY; COMPLEMENT; MICE; IMMUNOGENICITY; ANTIGENS; IGG1 AB Reports on the bactericidal activities of antibodies to group B Neisseria meningitidis capsular polysaccharide (B PS) are conflicting, Using three different complement sources, we analyzed the bactericidal activities of sera of juvenile rhesus monkeys immunized with five conjugate vaccines of B PS synthesized by different schemes, an Escherichia coli K92 conjugate, and a noncovalent complex of B PS with group B meningococcal outer membrane vesicles (B+OMV) (S. J. N. Devi, W. D. Zollinger, P. J. Snoy, J. Y. Tai, P. Costantini, F. Norelli, R. Rappuoli, and C. E. Frasch, Infect. Immun. 65:1045-1052, 1997). With rabbit complement, nearly all preimmune sera showed relatively high bactericidal titers, and all vaccines, except the K92 conjugate, induced a fourfold or greater increase in bactericidal titers in most of the monkeys vaccinated, In contrast, with human complement, most prevaccination sera showed no bactericidal activity and in most of the vaccine groups, little or no increase in bactericidal titer was observed, However, the covalent conjugation of P BS and OMV (B-OMV) administered with and without the Ribi adjuvant induced relatively high bactericidal titers which persisted up to 30 weeks, An analysis of the specificities of bactericidal antibodies revealed that absorption with E. coli K1 cells did not change the bactericidal titer with human complement but reduced the titers observed with the rabbit and monkey complements, A significant increase in anti-lipopolysaccharide (LPS) antibodies was elicited by the B-OMV conjugates, and nearly all of the bactericidal activity with human complement could be inhibited with the purified group B meningococcal L3,7,8 LPS. B-OMV covalently coupled via adipic acid dihydrazide elicited significantly elevated levels (P less than or equal to 0.02) of anti-OMV antibodies compared to those of the noncovalently complexed B+OMV, An initial small-scale evaluation of B PS conjugates in adult human males appears feasible, with careful monitoring, to settle the inconsistent reports of the importance of source of complement in eliciting bacteriolysis, Subsequent analysis of resultant human antibodies for bacteriolysis, opsonophagocytosis, and protective efficacy in animal models may be the first step toward answering safety-and efficacy-related concerns about B PS conjugate vaccines. C1 US FDA,DIV BACTERIAL PROD,OFF VACCINE RES & REVIEW,CTR BIOL EVALUAT & RES,ROCKVILLE,MD 20852. RP Zollinger, WD (reprint author), WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 38 TC 38 Z9 39 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAR PY 1997 VL 65 IS 3 BP 1053 EP 1060 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA WK953 UT WOS:A1997WK95300029 PM 9038315 ER PT J AU Duffy, PE Kaslow, DC AF Duffy, PE Kaslow, DC TI A novel malaria protein, Pfs28, and Pfs25 are genetically linked and synergistic as falciparum malaria transmission-blocking vaccines SO INFECTION AND IMMUNITY LA English DT Article ID PLASMODIUM-FALCIPARUM; SEXUAL STAGES; ANTIBODIES; EXPRESSION; ANTIGENS; PURIFICATION; CANDIDATE; IMMUNITY; YEAST AB Antibodies to Pfs28 block Plasmodium falciparum transmission and when combined with antibodies to Pfs25 provide synergy in blocking transmission. Pfs28 and Pfs25 are immunogenic, have limited antigenic diversity, and are structurally similar and genetically linked on chromosome 10. Pfs28 may prove a useful addition to Pfs25 in an effective transmission-blocking vaccine. C1 NIAID,PARASIT DIS LAB,MALARIA VACCINES SECT,NIH,BETHESDA,MD 20892. WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. NR 14 TC 110 Z9 116 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAR PY 1997 VL 65 IS 3 BP 1109 EP 1113 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA WK953 UT WOS:A1997WK95300039 PM 9038325 ER PT J AU Kramer, TR Moore, RJ Shippee, RL Friedl, KE MartinezLopez, L Chan, MM Askew, EW AF Kramer, TR Moore, RJ Shippee, RL Friedl, KE MartinezLopez, L Chan, MM Askew, EW TI Effects of food restriction in military training on T-lymphocyte responses SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article; Proceedings Paper CT 2nd Symposium of the International Society of Exercise and Immunology CY NOV 17-18, 1995 CL BRUSSELS, BELGIUM SP ISEI DE proliferation; interleukin-2 receptor; energy deficit; calories; exercise; energy expenditure ID EXERCISE; SUBPOPULATIONS; STRESS AB In a stress model which included food restriction, we examined the effects of physically rigorous military training and increased caloric intake on T-lymphocyte responses and lymphocyte subsets. T-lymphocyte proliferation and release of soluble receptor for interleukin-2 (sIL-2R) in vitro were measured in two separate training classes of male U.S. Army ranger course (RC) trainees at the start and during the RC. Trainees in group 1 (n = 55) and 2 (n = 50), respectively, had mean (+/- SD) energy intakes of 11.8 +/- 7.0 and 13.6 +/- 6.7 MJ/d, averaged total daily energy expenditures of 16.7 and 17.6 MJ/d, and experienced body weight losses of 15.6% and 12.6%. Both groups showed decreased T-lymphocyte responses in vitro: proliferation to phytohemagglutinin (PHA) and tetanus toroid (TT), and released sIL-2R to PHA. Group 2 with an intended 15% increase in energy during the RC over group 1 showed 22% and 26% less severe suppressions of T-lymphocyte proliferation and released sIL-2R, respectively, in vitro. Group 2 also showed that short-term (9 days) removal of the food restriction stressor allowed for corrected body weight, total lymphocyte and T-lymphocyte subset counts but not suppressed T-lymphocyte responses in vitro. These results demonstrate that soldiers in physically rigorous military training are at risk of suppressed T-lymphocyte immunocompetence, and this is greater if they also experience inadequate energy intake. C1 USDA,CAROTENOID RES UNIT,BELTSVILLE HUMAN NUTR RES CTR,BELTSVILLE,MD 20705. USA,ENVIRONM MED RES INST,NATICK,MA 01760. MARTIN ARMY COMMUNITY HOSP,DEPT FAMILY PRACTICE & COMMUNITY MED,FT BENNING,GA. CHILDRENS HOSP,NATL MED CTR,DEPT LAB MED,WASHINGTON,DC 20010. NR 18 TC 29 Z9 30 U1 0 U2 1 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0172-4622 J9 INT J SPORTS MED JI Int. J. Sports Med. PD MAR PY 1997 VL 18 SU 1 BP S84 EP S90 DI 10.1055/s-2007-972704 PG 7 WC Sport Sciences SC Sport Sciences GA WV027 UT WOS:A1997WV02700011 PM 9129267 ER PT J AU Broomfield, CA Filbert, MG AF Broomfield, CA Filbert, MG TI Spin-label studies on synaptic membrane lipids: Effect of cholinergic agonists, antagonists, and cholinesterase inhibitors SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE anticholinesterases; EPR; fluidity; organophosphates; spin labels; synaptosomes; Torpedo ID RECEPTOR-RICH MEMBRANES; TORPEDO-MARMORATA; ERYTHROCYTE-MEMBRANES; SOMAN; FLUIDITY; BINDING; PERTURBATION; FLEXIBILITY; ANESTHETICS; VESICLES AB The effects on membrane fluidity of inhibitors of acetylcholinesterase (AChE) as well as those of certain nicotinic agonists have been, examined in synaptosomes prepared from the electroplax of Torpedo californica. Electron paramagnetic resonance (EPR) spectrometry was used to monitor changes in the order parameters of three spin-labeled fatty acid probes, doxyl stearic acid derivatives, intercalated in the lipid bilayer of synaptosomal membranes. Neither inhibition of AChE nor the application of nicotinic ligands significantly influenced the viscosity of the membrane bilayer as judged by changes in the order parameters of the probes. A small, narrow line component of the EPR spectra disappeared when high concentrations of acetylcholine (ACh) were added to the synaptosomes. This effect was not seen. with other cholinergic agonists, e.g., carbachol. The results of this investigation suggest that if anti-AChEs produce damaging effects on the lipid components of nerve membranes, the effects are indirect, resulting from accumulation of high ACh levels and not from a direct action of the agent on the membrane lipid. C1 USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010. USA,MED RES INST CHEM DEF,NEUROTOXICOL BRANCH,DIV PATHOPHYSIOL,ABERDEEN PROVING GROUND,MD 21010. NR 43 TC 1 Z9 1 U1 3 U2 4 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 1091-5818 J9 INT J TOXICOL JI Int. J. Toxicol. PD MAR-APR PY 1997 VL 16 IS 2 BP 103 EP 117 PG 15 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA XB221 UT WOS:A1997XB22100001 ER PT J AU Reid, FM Menton, RG Audet, KK Marino, M Brewer, TG Korte, DW AF Reid, FM Menton, RG Audet, KK Marino, M Brewer, TG Korte, DW TI A nonlethal, anesthetized canine model for efficacy evaluation of anticyanide therapy SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE animal model; anticynaide therapy; cyanide; methemoglobin; nonlethal anesthetized animal model; sodium cyanide AB Efficacy evaluations of anticyanide therapeutic compounds historically have used lethality in unanesthetized animals as the toxic endpoint, and a nonlethal, repeated-testing, anesthetized canine model has been reported. Time to respiratory arrest (TRA) induced by a continuous, slow intravenous (IV) infusion of sodium cyanide (NaCN) was shown to be a consistent, well-defined endpoint in anesthetized canines. Thirty seconds after respiratory arrest (RA), an IV bolus of a methemoglobin-forming compound reversed the respiratory effects. This study was designed to determine the variability in TRA, survivability of anesthetized dogs repeatedly infused with NaCN and treated with hydroxylamine, replicability of the procedure within an animal and between animals, and development of trends in data. Four animals were anesthetized intubated, catheterized, and instrumented to record respiratory rate and heart rate. Immediately following baseline data collection, a 4-mg/mL. NaCN solution was infused at a rate of 2 mL/min. Following a 10-s period without functional respiration, infusion was stopped and this moment was designated as RA. Hydroxylamine therapy was administered 30 s after RA. There were 4 replicate experiments per animal with a 1-week washout period between replicates. Interanimal variability in TRA was significant (p = .04). The average variability in TRA within an animal was less than 10%. Baseline heart and respiratory rates were not altered significantly. Data confirm, by replicate testing, the utility of this model. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. CONCORDIA UNIV WISCONSIN,MEQUON,WI. RP Reid, FM (reprint author), BATTELLE MEM INST,505 KING AVE,COLUMBUS,OH 43201, USA. NR 10 TC 2 Z9 2 U1 0 U2 1 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 1091-5818 J9 INT J TOXICOL JI Int. J. Toxicol. PD MAR-APR PY 1997 VL 16 IS 2 BP 141 EP 149 DI 10.1080/109158197227233 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA XB221 UT WOS:A1997XB22100003 ER PT J AU Menton, RG Reid, FM Olson, CT Niemuth, NA Audet, KK Marino, M Brewer, TG Korte, DW AF Menton, RG Reid, FM Olson, CT Niemuth, NA Audet, KK Marino, M Brewer, TG Korte, DW TI Comparative efficacy of three methemoglobin formers in delaying effects of infused sodium cyanide SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE analysis of variance; anticyanide therapy; methemoglobin formers; sodium cyanide AB A prophylactic treatment is needed to circumvent constraints of the current therapy for cyanide (CN-) intoxication: intravenous administration of sodium nitrite and sodium thiosulfate. Experiments were conducted to compare the anticyanide effects of three candidate pretreatment methemoglobin (MHb)-forming compounds in an anesthetized animal model. The experiment was conducted in 5 periods, with each of 9 animals receiving the vehicle control in period 1, 0.2 mg/kg p-aminopropiophenone (PAPP) in period 2, and 2.5 mg/kg WR242511 in period 3. Four of the animals received the vehicle control in period 4 followed by 7 mg/kg p-aminoheptanophenone (PAHP) in period 5, and 5 animals received 7 mg/kg PAHP in period 4 followed by the vehicle control in period 5. Sodium cyanide (NaCN) infusions for PAPP, PAHP, and WR242511 experiments were initiated when the predicted MHb level was approximately 5%. Infusions were stopped 10 s after no functional breaths (respiratory arrest) were observed. Blood samples were collected for hemoglobin (Hb), MHb, and total blood CN- levels at scheduled time points. Time to respiratory arrest, percent MHb, and NaCN dose were the primary response parameters. All pretreatment regimens effectively mitigated the effects of NaCN poisoning compared to the vehicle control (p < .05). No discernable differences in protection were provided by the three compounds. The results indicated that the protective effect is related to the MHb level rather than the specific pretreatment drug. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. CONCORDIA UNIV WISCONSIN,MEQUON,WI. RP Menton, RG (reprint author), BATTELLE MEM INST,505 KING AVE,COLUMBUS,OH 43201, USA. NR 4 TC 2 Z9 2 U1 0 U2 1 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 1091-5818 J9 INT J TOXICOL JI Int. J. Toxicol. PD MAR-APR PY 1997 VL 16 IS 2 BP 151 EP 164 PG 14 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA XB221 UT WOS:A1997XB22100004 ER PT J AU Truax, AL Chandnani, VP Chacko, AK Gonzalez, DM AF Truax, AL Chandnani, VP Chacko, AK Gonzalez, DM TI Incidence and methods of diagnosis of musculoskeletal injuries incurred in operations Desert Shield and Desert Storm SO INVESTIGATIVE RADIOLOGY LA English DT Article DE ligaments; cartilage; fractures ID ROTATOR CUFF; TEARS AB RATIONALE AND OBJECTIVES. The authors studied the incidence and distribution of orthopedic injuries sustained in Operation Desert Shield and Desert Storm by evaluating whether existing diagnostic imaging modalities were sufficient to diagnose the types of musculoskeletal injuries incurred, The authors also sought to determine if a dedicated extremity MR scanner would provide monetary benefits and enhance military readiness, METHODS. The authors retrospectively reviewed data on all musculoskeletal injuries incurred in Desert Shield/Desert Storm to determine the total number of injuries, proportion of orthopedic injuries, number of soft-tissue orthopedic injuries, and the country where the diagnosis was established, The authors also determined the number of patients, duration, and economic impact of the evacuation process, RESULTS. There were 1011 fractures and 1177 soft-tissue injuries; 408 soft-tissue injuries were diagnosed in the Persian Gulf countries, and 769 diagnosed in the United States and Germany, The average time to evacuate these 769 patients was 21 days with an estimated replacement cost of $836,885, CONCLUSIONS. Musculoskeletal soft-tissue injuries comprised 34% of the overall injuries in the Persian Gulf War, and twice as many patients required evacuation for diagnosis as were diagnosed locally using existing imaging modalities, A dedicated extremity magnetic resonance scanner in the battlefield would obviate many evacuations and hence be of both monetary and military readiness benefit. C1 BROOKE ARMY MED CTR,MCHE DR,DEPT RADIOL,SAN ANTONIO,TX 78234. BROOKE ARMY MED CTR,DEPT ORTHOPED SURG,SAN ANTONIO,TX. NR 8 TC 7 Z9 10 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0020-9996 J9 INVEST RADIOL JI Invest. Radiol. PD MAR PY 1997 VL 32 IS 3 BP 169 EP 173 DI 10.1097/00004424-199703000-00006 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA WK555 UT WOS:A1997WK55500006 PM 9055130 ER PT J AU Michael, NL Chang, G Kim, JH Birx, DL AF Michael, NL Chang, G Kim, JH Birx, DL TI Dynamics of cell-free viral burden in HIV-1-infected patients SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE viral burden; serum RNA; HIV-1 ID IMMUNODEFICIENCY-VIRUS TYPE-1; MESSENGER-RNA EXPRESSION; PERIPHERAL-BLOOD CELLS; DISEASE PROGRESSION; NATURAL-HISTORY; INFECTION; HIV-1; INDIVIDUALS; LOAD; QUANTITATION AB Whereas previous cross-sectional studies have shown a 1-2 log increase in cell-free HIV-1 RNA viral burden associated with disease progression, recent longitudinal studies reveal a less dynamic association. We addressed this conundrum in a cohort of 17 rapid and 20 slow progressors. Initial levels of serum viral RNA from the rapid progressors were 1 log unit higher than those from the slow progressors. Serum RNA increased by >0.5 log in 10 of the rapid progressors (increase group), but the remaining seven showed a <0.5 log increase (static group). Patients whose serum RNA increased had lower amounts of serum RNA at study entry but not at follow-up compared with the static group. There was a trend toward lower CD4 counts in the static group at followup. These data suggest that the timing of specimen evaluation can influence interpretation of viral RNA dynamics in HIV disease. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. HENRY M JACKSON FDN,ROCKVILLE,MD. NR 16 TC 13 Z9 13 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD MAR 1 PY 1997 VL 14 IS 3 BP 237 EP 242 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA WP137 UT WOS:A1997WP13700007 PM 9117456 ER PT J AU Johnson, JM AF Johnson, JM TI The siege of Fort Cumberland, 1776: An episode in the American Revolution - Clarke,E SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review RP Johnson, JM (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD MAR PY 1997 VL 83 IS 4 BP 1381 EP 1382 DI 10.2307/2952930 PG 2 WC History SC History GA WQ579 UT WOS:A1997WQ57900039 ER PT J AU Johnson, JM AF Johnson, JM TI Benjamin Lincoln and the American Revolution - Mattern,DB SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review RP Johnson, JM (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD MAR PY 1997 VL 83 IS 4 BP 1381 EP 1382 DI 10.2307/2952930 PG 2 WC History SC History GA WQ579 UT WOS:A1997WQ57900040 ER PT J AU Kaushal, S LaRussa, VF Hall, ER Gartner, S Kim, JH Perera, LP Yu, Z Kessler, SW Mosca, JD AF Kaushal, S LaRussa, VF Hall, ER Gartner, S Kim, JH Perera, LP Yu, Z Kessler, SW Mosca, JD TI Providing a microenvironment for the development of human CD34+ hematopoietic cells in SCID mice SO JOURNAL OF BIOMEDICAL SCIENCE LA English DT Article DE SCID mice; hematopoiesis; stromal cells; CD34+ cells; microenvironment ID TUMOR-NECROSIS-FACTOR; BONE-MARROW; HU MICE; STEM-CELLS; ANTIGENIC ANALYSIS; PROGENITOR CELLS; IN-VITRO; MOUSE; DIFFERENTIATION; GROWTH AB In order to develop a convenient small-animal model that can support the differentiation of human bone-marrow-derived CD34+ cells, we transplanted SCID mice with an immortalized human stromal cell line, Lof(11-10). The Lof(11-10) cell line has been characterized to produce human cytokines capable of supporting primitive human hematopoietic cell proliferation in vitro. Intraperitoneal injection of Lof(11-10) cells into irradiated SCID mice by itself resulted in a dose-dependent survival of the mice from lethal irradiation. The radioprotective survival was reflected by an increase in the growth and number of mouse bone-marrow-derived committed hematopoietic progenitors. The Lof(11-10) cells localized to the spleen, but not to the bone marrow of these animals and resulted in detectable levels of circulating human IL-6 in their plasma. Secondary intravenous injections of either human or simian CD34+ cells into the Lof(11-10)-transplanted SCID mice resulted in engraftment of injected cells within the bone marrow of these mice. The utility of this small-animal model that allows the growth and differentiation of human CD34+ cells and its potential use in clinical gene therapy protocols are discussed. C1 OSIRIS THERAPEUT INC,BALTIMORE,MD 21231. HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD. WALTER REED ARMY INST RES,ROCKVILLE,MD. TULANE CANC CTR,BONE MARROW TRANSPLANTAT PROGRAM,NEW ORLEANS,LA. UNIV MARYLAND,INST HUMAN VIROL,BALTIMORE,MD 21201. JOHNS HOPKINS UNIV HOSP,DEPT NEUROL,BALTIMORE,MD 21287. NIAID,NIH,BETHESDA,MD 20892. SYSTEMIX,PALO ALTO,CA. USN,MED RES UNIT 3,CAIRO,EGYPT. NR 32 TC 1 Z9 1 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1021-7770 J9 J BIOMED SCI JI J. Biomed. Sci. PD MAR-JUN PY 1997 VL 4 IS 2-3 BP 61 EP 68 DI 10.1007/BF02255595 PG 8 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA YD087 UT WOS:A1997YD08700001 ER PT J AU Kim, IK Li, CCH Young, HA Lee, JH Kim, HS Pardhasaradhi, K Garcia, GE Chiang, PK AF Kim, IK Li, CCH Young, HA Lee, JH Kim, HS Pardhasaradhi, K Garcia, GE Chiang, PK TI Apoptosis of L1210 leukemia cells induced by 3-deazaadenosine analogs: Differential expression of c-myc, NF-Kappa B and molecular events SO JOURNAL OF BIOMEDICAL SCIENCE LA English DT Article DE apoptosis; cell cycle; 3-deazaadenosine analogs; L1210 lymphocytic leukemia cells; c-myc; NF-kappa B ID S-ADENOSYLHOMOCYSTEINE HYDROLASE; LEUKOCYTE ADHESION; ENDOTHELIAL-CELLS; MOUSE THYMOCYTES; GENE-EXPRESSION; HL-60 CELLS; ACTIVATION; DEATH; INDUCTION; P53 AB A new class of potent apogens (apoptosis-inducing agents) has been identified, consisting of 3-deazaadenosine (DZA), 3-deaza-(+/-)aristeromycin (DZAri) and 1-beta-D-arabinofuranosyl-1H-imidazo[4,5-(c) under bax-pyridine (ara-3-deazaadenine; DZAra-A). They are inhibitors of S-adenosylhomocysteine hydrolase and indirect inhibitors of methylation. Furthermore, they have also been found to form 3-deaza-nucleotide analogs. The DZA analogs, DZA, DZAri, and DZAra-A, induced DNA fragmentation in a dose-and time-dependent manner, reaching a maximum at 250 mu M after 72 h. Cycloheximide at 0.5 mu g/ml completely blocked the DNA fragmentation induced by 250 mu M of each of the analogs. Interestingly, exogenous 100 mu M L-homocysteine thiolactone abrogated the DNA fragmentation caused by DZAri and DZAra-A? but not by DZA. Flow cytometric analysis showed that DZA arrested the cells in the G(2)/M phase, whereas the S phase was arrested by DZAri. Correlated with the effect of DZA was a rapid decrease in the expression of c-myc, whereas nur77 and GAPDH were unaffected. In comparison, there was an elevated expression of IFN-gamma mRNA without apparent change in bax, p53 or GAPDH mRNA after 24 h. After treatment with DZA, there was an elevated expression of NF-kappa B DNA binding activity, which became more pronounced at 24 h. Simultaneously, there was an apparent disappearance of AP-1 activity. Thus, DZA most likely inhibited the RNA synthesis of c-myc, a reduction of which could trigger a cascade of gene transcription leading to apoptosis in L1210 cells. C1 WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. CATHOLIC UNIV, COLL MED, DEPT BIOCHEM, SEOUL, SOUTH KOREA. NCI, FREDERICK CANC RES & DEV CTR, INTRAMURAL RES SUPPORT PROGRAM, FREDERICK, MD 21702 USA. NCI, FREDERICK CANC RES & DEV CTR, EXPT IMMUNOL LAB, FREDERICK, MD 21702 USA. NR 42 TC 10 Z9 10 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1021-7770 J9 J BIOMED SCI JI J. Biomed. Sci. PD MAR-JUN PY 1997 VL 4 IS 2-3 BP 83 EP 90 DI 10.1007/BF02255598 PG 8 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA YD087 UT WOS:A1997YD08700004 ER PT J AU Jin, YD Fuller, L Carreno, M Zucker, K Roth, D Esquenazi, V Karatzas, T Swanson, SJ Tsakis, AG Miller, J AF Jin, YD Fuller, L Carreno, M Zucker, K Roth, D Esquenazi, V Karatzas, T Swanson, SJ Tsakis, AG Miller, J TI The immune reactivity role of HCV-induced liver infiltrating lymphocytes in hepatocellular damage SO JOURNAL OF CLINICAL IMMUNOLOGY LA English DT Article DE hepatitis C virus; end-stage liver disease; liver infiltrating lymphocyte; intermediate T cells ID HEPATITIS-C VIRUS; CELL RECEPTOR-ALPHA/BETA(+) CELLS; T-CELLS; MEDIATED CYTOTOXICITY; EXPRESSION; MICE; ANTIGENS; FAS; INVOLVEMENT; EMERGENCE AB Liver infiltrating lymphocytes (LIL) were isolated from HCV-positive (+) and HCV-negative (-) end-stage livers. Phenotypic analysis and functional studies using proliferative and lymphocytotoxic assays were performed with the isolated LIL. Two CD3+ lymphocyte populations were found in LIL using FITC anti-CD3 monoclonal antibodies (mAb), One was a bright fluorescence intensity population (as in PBL), and the other dim. We calculated the number of FITC-anti-CD3 mAbs bound per lymphocyte on PBL and LV, and found 80,040 +/- 4628 and 39.615 +/- 3932, respectively. Therefore, HCV+ and HCV- patient PBL contained approximately twice the number of CD3 molecules per cell than patient CD3+ LIL. LIL also contained approximately a threefold higher concentration of TCR alpha beta+, CD4-CD8-, and CD56,16 (NK) cells than the patient PBL. Thus, a major subset of LIL is phenotypically similar to mouse NK1.1+ ''intermediate'' T cells. LIL freshly isolated from HCV+ livers exhibited weak CTL activity against EBV- or Con A-transformed lymphoblast targets infected with vaccinia-HCV recombinant virus (rHCV) or primary hepatocyte cultured cells. However, after in vitro a coculture of LIL with rHCV, these cells developed a strong cytotoxicity for the above targets. In contrast, LIL from HCV-livers were not cytotoxic against the same targets. Histochemical studies (in situ) demonstrated that these hepatocytes express CD95, and stains demonstrated apoptosis. The HCV+ hepatocytes also express class I MHC molecules and ICAM-1. The addition of mAb specific for these adhesion molecules inhibited CML activity. Short-term cultured hepatocytes (targets) from HCV+ and HCV- patients produced low levels of cytokines IL-1 beta, IL-2, IL-6, TNF alpha, and IFN-gamma but a high level of IL-8. It is speculated that LIL expressing reduced numbers of CD3 molecules may even function as immune regulators as proposed for intermediate T cells in mice. C1 UNIV MIAMI,SCH MED,DIV MICROBIOL IMMUNOL,MIAMI,FL 33101. MIAMI VET ADM MED CTR,MIAMI,FL. WALTER REED ARMY MED CTR,ORGAN TRANSPLANT SERV,WASHINGTON,DC 20307. RP Jin, YD (reprint author), UNIV MIAMI,SCH MED,DEPT SURG,DIV TRANSPLANTAT,POB 012440,MIAMI,FL 33101, USA. NR 24 TC 32 Z9 33 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0271-9142 J9 J CLIN IMMUNOL JI J. Clin. Immunol. PD MAR PY 1997 VL 17 IS 2 BP 140 EP 153 DI 10.1023/A:1027326415164 PG 14 WC Immunology SC Immunology GA WP396 UT WOS:A1997WP39600003 PM 9083890 ER PT J AU Doellgast, GJ Brown, JE Koufman, JA Hatheway, CL AF Doellgast, GJ Brown, JE Koufman, JA Hatheway, CL TI Sensitive assay for measurement of antibodies to Clostridium botulinum neurotoxins A, B, and E: Use of Hapten-labeled-antibody elution to isolate specific complexes SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; SOLUTION-PHASE COMPLEXES; COAGULATION ASSAY; TOXIN AB The measurement of chicken and human antibodies to Clostridium botulinum neurotoxins A, B, and E was accomplished by affinity isolation of complexes containing these antibodies. By this approach, a mixture of toxin with the test antibody, fluoresceinated antibody, and enzyme (Russell's viper venom factor X activator)-labeled antibody is allowed to form a complex in solution phase. This complex is then bound to a matrix containing antifluorescein antibody. All components not bound to the matrix are washed off, and the complex is isolated intact by elution with fluorescein, which competes with the complex for binding to the antifluorescein matrix. The eluted complex is then bound to a matrix which specifically binds the test antibody (anti-chicken immunoglobulin Y [IgY] or anti-human IgG), and the bound complex is measured by using the enzyme label. Using this approach, we were able to measure as little as 1 ng of specific antibody per mi from affinity-isolated, monospecific chicken antibody preparations and to measure antibody specifically from IgY fractions of monospecific chicken antibody preparations. Human antibodies from subjects immunized with pentavalent toroid preparations were detectable at dilutions as great as 24,300-fold, and undiluted serum from most control subjects showed no measurable antibody. Antibody was also measured in 65 subjects who were receiving preparations of neurotoxin A (BOTOX) for the treatment of spastic disorders. Eighteen of them had toxin-specific antibody reactive with toxin B, and two of them had toxin-specific antibody reactive with toxin A. The two patients having antibody to toxin A were refractory to treatment with this toxin. This approach of isolation of hapten-labeled immune complexes under nondenaturing conditions with hapten is broadly applicable to the specific measurement of antibodies present at very low concentrations in serum. C1 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT OTOLARYNGOL,WINSTON SALEM,NC 27157. ELCATECH INC,WINSTON SALEM,NC 27101. USA,CTR HLTH PROMOT & PREVENT MED,ABERDEEN PROVING GROUND,MD 21010. CTR DIS CONTROL & PREVENT,BOTULISM LAB,ATLANTA,GA 30333. RP Doellgast, GJ (reprint author), WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT BIOCHEM,MED CTR BLVD,WINSTON SALEM,NC 27157, USA. NR 13 TC 21 Z9 23 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAR PY 1997 VL 35 IS 3 BP 578 EP 583 PG 6 WC Microbiology SC Microbiology GA WJ848 UT WOS:A1997WJ84800009 PM 9041392 ER PT J AU Marschner, IC Mayers, DL Erice, A Smeaton, L Johnson, VA Richman, DD Reichelderfer, P Japour, AJ AF Marschner, IC Mayers, DL Erice, A Smeaton, L Johnson, VA Richman, DD Reichelderfer, P Japour, AJ TI Standardized peripheral blood mononuclear cell culture assay for zidovudine susceptibility testing of clinical human immunodeficiency virus type 1 isolates: Effect of reducing the numbers of replicates and concentrations SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article AB Zidovudine susceptibility was assessed for 525 clinical human immunodeficiency virus type 1 isolates, before and after reducing the number of replicates and zidovudine concentrations in the standardized consensus peripheral blood mononuclear cell culture assay. We conclude that omitting the 0.001 mu M concentration and using duplicate rather than triplicate wells are valid and cost-effective modifications of this expensive assay. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. UNIV MINNESOTA,DEPT LAB MED & PATHOL,MINNEAPOLIS,MN 55455. UNIV ALABAMA,SCH MED,DEPT MED,DIV INFECT DIS,BIRMINGHAM,AL 35294. VET AFFAIRS MED CTR,BIRMINGHAM,AL 35294. VET AFFAIRS MED CTR,SAN DIEGO,CA 92093. UNIV CALIF SAN DIEGO,DEPT PATHOL,SAN DIEGO,CA 92093. UNIV CALIF SAN DIEGO,DEPT MED,SAN DIEGO,CA 92093. NIAID,DIV AIDS,BETHESDA,MD 20892. BETH ISRAEL HOSP,DIV INFECT DIS,BOSTON,MA 02115. RP Marschner, IC (reprint author), HARVARD UNIV,SCH PUBL HLTH,CTR BIOSTAT AIDS RES,KRESGE 7,677 HUNTINGTON AVE,BOSTON,MA 02115, USA. FU NIAID NIH HHS [AI32777, AI27670, AI32794] NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAR PY 1997 VL 35 IS 3 BP 756 EP 758 PG 3 WC Microbiology SC Microbiology GA WJ848 UT WOS:A1997WJ84800045 PM 9041428 ER PT J AU Larson, R Morang, A Gorman, L AF Larson, R Morang, A Gorman, L TI Monitoring the coastal environment .2. Sediment sampling and geotechnical methods SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE goring methods; vibratory corers; grain-size analyses; sieves; sediment statistics; coring logs AB The successful application of a variety of subaqueous sediment sampling devices depends upon several criteria. These criteria include an understanding of the depth and purpose of sampling, the anticipated character of the material to be sampled, and the depositional energy environments of the sample zone. Samples provide geologic information on the mineralogic content and condition. Proxmity, sequence and magnitude of sediment units or zones provide energy system change rates, source areas variations, and mechanisms of sediment emplacement. Dynamic conditions during and after sediment deposition produce features and bed forms such as ripples, dunes, and bedding. Using techniques that no not disturb or cause only minimal disturbance of the target sediment zones is important in the ultimate analysis of the subaqueous system. Description of commonly-available samplers, standard operating procedures, and methods of analysis are provided to give guidance for the successful collection and interpretation of subaqueous sediment environments. C1 USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180. USA,ENGINEER WATERWAYS EXPT STN,INFORMAT TECHNOL LAB,VICKSBURG,MS 39180. RP Larson, R (reprint author), USA,ENGINEER WATERWAYS EXPT STN,GEOTECH LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 74 TC 24 Z9 24 U1 0 U2 1 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SPR PY 1997 VL 13 IS 2 BP 308 EP 330 PG 23 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA WW936 UT WOS:A1997WW93600004 ER PT J AU RichterMenge, JA Schulson, EM AF RichterMenge, JA Schulson, EM TI Mechanical properties of first-year sea ice at Tarsiut Island - Discussion SO JOURNAL OF COLD REGIONS ENGINEERING LA English DT Editorial Material ID BRITTLE COMPRESSIVE FAILURE; COLUMNAR SALINE ICE; STRENGTH C1 DARTMOUTH COLL,THAYER SCH ENGN,HANOVER,NH 03755. RP RichterMenge, JA (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 30 TC 0 Z9 0 U1 1 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0887-381X J9 J COLD REG ENG JI J. Cold Reg. Eng. PD MAR PY 1997 VL 11 IS 1 BP 93 EP 96 DI 10.1061/(ASCE)0887-381X(1997)11:1(93) PG 4 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA WL336 UT WOS:A1997WL33600009 ER PT J AU Li, ST Petzold, L AF Li, ST Petzold, L TI Moving mesh methods with upwinding schemes for time-dependent PDEs SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article ID PARTIAL-DIFFERENTIAL EQUATIONS; HYPERBOLIC CONSERVATION-LAWS; ADAPTIVE GRIDS AB It is well known that moving mesh and upwinding schemes are two kinds of techniques for tracking the shock or steep wave front in the solution of PDEs. It is expected that their combination should produce more robust methods. Several upwinding schemes are considered for non-uniform meshes. A self-adaptive moving mesh method is also described. Numerical examples are given to illustrate that in some cases, especially for hyperbolic conservative laws with nonconvex flux, the upwinding schemes improve the results of the moving mesh methods. Comparing the results of several upwinding schemes, we find the local piecewise hyperbolic method (PHM) is very efficient and accurate when combined with a moving mesh strategy. (C) 1997 Academic Press. C1 UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. RP Li, ST (reprint author), UNIV MINNESOTA, DEPT COMP SCI, MINNEAPOLIS, MN 55455 USA. NR 26 TC 50 Z9 50 U1 1 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 EI 1090-2716 J9 J COMPUT PHYS JI J. Comput. Phys. PD MAR 1 PY 1997 VL 131 IS 2 BP 368 EP 377 DI 10.1006/jcph.1996.5611 PG 10 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA WL609 UT WOS:A1997WL60900009 ER PT J AU Kuppurao, S Derby, JJ AF Kuppurao, S Derby, JJ TI Designing thermal environments to promote convex interface shapes during the vertical Bridgman growth of cadmium zinc telluride SO JOURNAL OF CRYSTAL GROWTH LA English DT Article ID HEAT-TRANSFER; CRYSTAL-GROWTH; DIRECTIONAL SOLIDIFICATION; SEMITRANSPARENT CRYSTALS; NUMERICAL-SIMULATION; CONVECTION; MELT; SEGREGATION; FURNACE; SILICON AB A finite element model for heat transfer, melt convection, and interface position is employed to analyze the role of support materials and ampoule geometry in influencing initial solidification during the vertical Brid,oman growth of CdZnTe. Simulations show that the shape of the solid-liquid interface is determined by a delicate balance between axial and radial heat flows and that this balance is controlled during the growth through the cone region of the ampoule by the configuration of the ampoule and support. A design which features an ampoule with a shallow cone sitting upon a composite support made of a highly conducting core and a less conducting outer sheath promotes axial heat transfer while inhibiting radial thermal flow, thus resulting in an interface shape which is convex toward the melt. Such an interface shape may be favorable for increasing process yields and may also facilitate seeded growth. For the system studied here, a hollow core, which acts as a radiation channel to enhance axial heat transfer, is not found to be as effective as a highly conductive core in enabling convex interface shapes. C1 UNIV MINNESOTA,DEPT CHEM ENGN & MAT SCI,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HPC RES CTR,MINNEAPOLIS,MN 55455. RI Derby, Jeffrey/B-9706-2009; OI Derby, Jeffrey/0000-0001-6418-2155 NR 41 TC 51 Z9 54 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD MAR PY 1997 VL 172 IS 3-4 BP 350 EP 360 DI 10.1016/S0022-0248(96)00756-7 PG 11 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA WL653 UT WOS:A1997WL65300009 ER PT J AU Smith, KJ Graham, JS Skelton, HG OLeary, T Moeller, RB Okerberg, CV Hurst, CG AF Smith, KJ Graham, JS Skelton, HG OLeary, T Moeller, RB Okerberg, CV Hurst, CG TI Evaluation of cross-reacting anti-human antibodies in the euthymic hairless guinea pig model (HGP) suggests that the HGP may be a model for the study of proliferative skin disease SO JOURNAL OF DERMATOLOGICAL SCIENCE LA English DT Article DE hairless guinea pig; proliferation kinetics; PCNA; p53; Ki-67 ID P53; CYCLIN; EXPRESSION; PROTEIN; ARREST AB Animal models have an important role in cutaneous research. The guinea pig has proven to be a useful model in a wide spectrum of these cutaneous studies; however, its usefulness is often compromised by the need for depilation. A euthymic hairless guinea pig (HGP) model avoids the problems associated with depilation. Morphologically, as in human skin, these animals have a multi-cell-layer epidermis. Proliferation kinetic studies, as well as documentation of the degree of immunologic cross-reactivity between available antibodies to human cutaneous antigens, could extend the usefulness of this animal model. We performed a battery of anti-human antibodies on formalin fixed tissue, to a variety of antigens present within the skin and on inflammatory cells. These included CD3, UCHL-1, OPD4, L-26, KP-I, Factor XIIIa, S-100 protein, cytokeratin (AE1, AE3 and CK1), CAM 5.2, vimentin, CD 34, Factor VIII, fibronectin, SM actin, collagen IV, laminin, Bcl-2, p53, Ki-67, and PCNA. Cross-reacting antibodies included: CD3 S-100 protein, cytokeratin (AE1, AE3 and CK1), vimentin, Factor VIII, SM actin, collagen IV, p53, Ki-67, and PCNA. Although this battery of antibodies is limited, the markedly increased staining of Ki-67 and PCNA within keratinocytes in the epidermis as compared to normal human skin reflects a high proliferative rate. In addition, positive staining for p53, Ki-67, and PCNA may be useful in studying effects on cell cycle kinetics and apoptosis.Although inflammatory cells and stromal and basement membrane antibodies showed limited cross-reactivity, these as well as the other markers used in this study, may prove useful in the HGP model. (C) 1997 Elsevier Science Ireland Ltd. C1 ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20307 USA. ARMED FORCES INST PATHOL, DEPT BIOL CHEM, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD USA. USA, MED RES INST CHEM DEF, ABERDEEN PROVING GROUND, MD 21010 USA. BIOL & CHEM MATTERS, ARLINGTON, VA 22345 USA. NR 17 TC 7 Z9 7 U1 0 U2 1 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0923-1811 J9 J DERMATOL SCI JI J. Dermatol. Sci. PD MAR PY 1997 VL 14 IS 3 BP 240 EP 250 DI 10.1016/S0923-1811(96)00580-4 PG 11 WC Dermatology SC Dermatology GA WL796 UT WOS:A1997WL79600009 PM 9138482 ER PT J AU Tang, PN Palazzolo, AB Kascak, AF Montague, GT AF Tang, PN Palazzolo, AB Kascak, AF Montague, GT TI Electromechanical modeling of hybrid piezohydraulic actuator system for active vibration control SO JOURNAL OF DYNAMIC SYSTEMS MEASUREMENT AND CONTROL-TRANSACTIONS OF THE ASME LA English DT Article AB Electromechanical modelling of a hybrid piezohydraulic actuator system for active vibration control was developed. The transfer function of piezoelectric actuator was derived from the electromechanical potential energy law. This transfer function represents the dynamic relationship between en input electric voltage and piezoelectric actuator displacement. The hydraulic actuator was characterized by impedance matching in which its transfer functions were experimentally determined. The transfer functions were transformed into a state-space representation, which is easily assembled into an active vibration control (AVC) closed-loop simulation. Good correlation of simulation and test was achieved for the hybrid system. A closed-loop dynamic simulation for imbalance response with/without AVC of a spinning rotor test rig at NASA Lewis was performed and showed excellent agreement with test results. The simulation couples the piezoelectric, hydraulic, and structural (rotor) components. C1 NASA,LEWIS RES CTR,USA,CLEVELAND,OH 44135. RP Tang, PN (reprint author), TEXAS A&M UNIV,COLLEGE STN,TX 77843, USA. NR 11 TC 3 Z9 3 U1 0 U2 1 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0022-0434 J9 J DYN SYST-T ASME JI J. Dyn. Syst. Meas. Control-Trans. ASME PD MAR PY 1997 VL 119 IS 1 BP 10 EP 18 DI 10.1115/1.2801199 PG 9 WC Automation & Control Systems; Instruments & Instrumentation SC Automation & Control Systems; Instruments & Instrumentation GA WN866 UT WOS:A1997WN86600003 ER PT J AU Ringelberg, DB Stair, JO Almeida, J Norby, RJ ONeill, EG White, DC AF Ringelberg, DB Stair, JO Almeida, J Norby, RJ ONeill, EG White, DC TI Consequences of rising atmospheric carbon dioxide levels for the belowground microbiota associated with white oak SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID POLY-BETA-HYDROXYBUTYRATE; FATTY-ACIDS; MYCORRHIZAL COLONIZATION; PLANT-RESPONSES; ELEVATED CO2; QUERCUS-ALBA; GROWTH; BIOMASS; RHIZOSPHERE; ENRICHMENT AB The consequences for belowground microbiota under conditions of rising atmospheric CO2 are largely unknown. In this research we examined the microbiota associated with white oak (Quercus alba L.). It was our hypothesis that an increase in CO2 level would induce a change in the rhizosphere-associated microbial abundance and community composition. To provide an in situ estimation of microbial abundance and community composition, ester-linked polar lipid fatty acid (PLFA) technology was utilized. This technology, based on the quantitative measurement of membrane lipid fatty acids, has been utilized in the accurate identification and description of bacterial isolates and communities. Initial experiments demonstrated that a clear distinction in lipid patterns and microbial biomass existed between sterile roots and those of roots containing an associated viable microbiota. Statistical approaches were then used to determine what differences existed between individual PLFA and PLFA patterns obtained from white oak fine roots and bulk soils. An analysis of variance (ANOVA) showed significant differences to exist in the relative percentages of individual prokaryotic PLFA collected under ambient vs. elevated CO2 and between those associated with fine roots and bulk soils. Multivariate statistics showed distinct differences in the patterns of prokaryotic PLFA detected in the rhizosphere vs. the surrounding bulk soil, but did not identify differences related to elevated CO2 exposures. An artificial neural network recognized PLFA patterns unique to three different CO2 exposures: similar to 35, similar to 50, and similar to 65 Pa. Results of the three statistical tests were viewed as supportive of the hypothesis describing significant differences in individual PLFA and patterns of PLFA as a result of elevated CO2 exposure. C1 UNIV TENNESSEE,CTR ENVIRONM BIOTECHNOL,KNOXVILLE,TN 37932. OAK RIDGE NATL LAB,DIV ENVIRONM SCI,OAK RIDGE,TN 37831. RP Ringelberg, DB (reprint author), DYNTEL CORP,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. RI Norby, Richard/C-1773-2012 OI Norby, Richard/0000-0002-0238-9828 NR 36 TC 47 Z9 50 U1 0 U2 19 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 SN 0047-2425 J9 J ENVIRON QUAL JI J. Environ. Qual. PD MAR-APR PY 1997 VL 26 IS 2 BP 495 EP 503 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA WP039 UT WOS:A1997WP03900021 ER PT J AU OKane, BL Biederman, I Cooper, EE Nystrom, B AF OKane, BL Biederman, I Cooper, EE Nystrom, B TI An account of object identification confusions SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-APPLIED LA English DT Article ID 3-DIMENSIONAL OBJECTS; RECOGNITION; CATEGORIES; NETWORK; PARTS AB In 2 experiments, trained military observers identified vehicles in infrared (thermal) imagery that varied in distance, signal-to-noise ratio, and orientation. A measure of shape similarity was derived from a contingency tree that allowed prediction of the confusion rates between any 2 vehicles on the basis of the number of detectable, distinguishing parts. The mean confusion rates between pairs of vehicles were strongly correlated with the nodal distance between these vehicles in the similarity trees, even though the similarity trees had been constructed without knowledge of the confusion rates. Such trees offer the possibility for substantial improvements in the modeling of human object identification and, when incorporated into training programs, offer a high potential for reducing the likelihood of identification errors. C1 E OIR MEASUREMENTS INC,SPOTSYLVANIA,VA. IOWA STATE UNIV,DEPT PSYCHOL,AMES,IA 50011. USA,CECOM,NIGHT VIS & ELECT SENSORS DIRECTORATE,FT BELVOIR,VA 22060. RP OKane, BL (reprint author), UNIV SO CALIF,DEPT PSYCHOL,HEDCO NEUROSCI BLDG,MC 2520,LOS ANGELES,CA 90089, USA. NR 32 TC 11 Z9 11 U1 1 U2 1 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 1076-898X J9 J EXP PSYCHOL-APPL JI J. Exp. Psychol.-Appl. PD MAR PY 1997 VL 3 IS 1 BP 21 EP 41 DI 10.1037/1076-898X.3.1.21 PG 21 WC Psychology, Applied SC Psychology GA WP843 UT WOS:A1997WP84300002 ER PT J AU Worfel, RC Schneider, KS Yang, TCS AF Worfel, RC Schneider, KS Yang, TCS TI Suppressive effect of allyl isothiocyanate on populations of stored grain insect pests SO JOURNAL OF FOOD PROCESSING AND PRESERVATION LA English DT Article ID FOOD PRESERVATION; VAPOR AB The efficiency of the WasaOuro(R) system, based on an extract derived from Cruciferiae plants, was investigated as an insect suppressing agent. The active ingredient was allyl isothiocyanate (AIT). Lasioderma serricorne and Tribolium confusum were exposed to AIT vapor in vented containers. The containers were maintained in a temperature- and humidity-controlled room. The WasaOuro system does not repel or attract L. serricorne but does reduce tunneling activity of T. confusum. AIT disrupts normal reproductive cycles of both L. serricorne and T. confusum resulting in an insect population reduction in grain foods. C1 USA,NATICK RES DEV & ENGN CTR,RAT SYST DIV,SUSTAINABIL DIRECTORATE,SOLDIER SYST COMMAND,NATICK,MA 01760. NR 7 TC 15 Z9 17 U1 0 U2 1 PU FOOD NUTRITION PRESS INC PI TRUMBULL PA 6527 MAIN ST, P O BOX 374, TRUMBULL, CT 06611 SN 0145-8892 J9 J FOOD PROCESS PRES JI J. Food Process Preserv. PD MAR PY 1997 VL 21 IS 1 BP 9 EP 19 DI 10.1111/j.1745-4549.1997.tb00764.x PG 11 WC Food Science & Technology SC Food Science & Technology GA WP103 UT WOS:A1997WP10300002 ER PT J AU Kraus, JF Benson, CH Erickson, AE Chamberlain, EJ AF Kraus, JF Benson, CH Erickson, AE Chamberlain, EJ TI Freeze-thaw cycling and hydraulic conductivity of bentonitic barriers SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article ID COMPACTED CLAY; PERMEABILITY AB Hydraulic conductivity tests were conducted in the laboratory and field on geosynthetic clay liners (GCLs) and a sand-bentonite mixture to determine if their hydraulic conductivity is affected by freezing and thawing. In the laboratory, specimens of three GCLs were frozen and thawed 20 times, and no increase in hydraulic conductivity was measured. The hydraulic conductivity of the compacted sand-bentonite also did not increase after freezing and thawing. In the field, two types of GCLs and a sand-bentonite test pad (constructed with the same mixture used in the laboratory) were exposed to one or two winters of freeze-thaw cycling. No large increase in hydraulic conductivity was measured for the field test conducted with the sand-bentonite mixture. An increase in hydraulic conductivity was observed in only one of the field tests with GCLs. Examination of thawed GCLs and specimens of the sand-bentonite mixture showed no evidence of cracking that is commonly found in thawed compacted clays. C1 UNIV WISCONSIN,DEPT CIVIL & ENVIRONM ENGN,MADISON,WI 53706. CH2M HILL INC,MILWAUKEE,WI 53202. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP Kraus, JF (reprint author), CH2M HILL INC,CHICAGO,IL 60631, USA. NR 24 TC 55 Z9 56 U1 0 U2 7 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD MAR PY 1997 VL 123 IS 3 BP 229 EP 238 DI 10.1061/(ASCE)1090-0241(1997)123:3(229) PG 10 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA WL337 UT WOS:A1997WL33700006 ER PT J AU Lewicki, DG Ballarini, R AF Lewicki, DG Ballarini, R TI Effect of rim thickness on gear crack propagation path SO JOURNAL OF MECHANICAL DESIGN LA English DT Article ID STRESS INTENSITY FACTOR; TOOTH AB Analytical and experimental studies were performed to investigate the effect of rim thickness on gear tooth crack propagation. The goal was to determine whether cracks grew through gear teeth or through gear rims for various rim thicknesses. A finite element based computer program (FRANC, FRacture ANalysis Code) simulated gear tooth crack propagation. The analysis used principles of linear elastic fracture mechanics. Quarter-point, triangular elements were used at the crack tip to represent the stress singularity. The program had an automated crack propagation option in which cracks were grown numerically using an automated re-meshing scheme. Crack tip stress intensity factors were estimated to determine crack propagation direction. Gears with various backup ratios (rim thickness divided by tooth height) were tested to validate crack path predictions. Gear bending fatigue tests were performed in a spur gear fatigue rig. From both predictions and tests, gears with backup ratios of 3.3 and 1.0 produced tooth fractures while a backup ratio of 0.3 produced rim fractures. For a backup ratio of 0.5, the experiments produced rim fractures and the predictions produced both rim and tooth fractures, depending on the initial geometry of the crack. RP Lewicki, DG (reprint author), USA,RES LAB,NASA,LEWIS RES CTR,VEHICLE PROP DIRECTORATE,CLEVELAND,OH, USA. NR 25 TC 30 Z9 32 U1 1 U2 3 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 1050-0472 J9 J MECH DESIGN JI J. Mech. Des. PD MAR PY 1997 VL 119 IS 1 BP 88 EP 95 DI 10.1115/1.2828793 PG 8 WC Engineering, Mechanical SC Engineering GA WT434 UT WOS:A1997WT43400013 ER PT J AU Black, GE Snyder, AP Heroux, KS AF Black, GE Snyder, AP Heroux, KS TI Chemotaxonomic differentiation between the Bacillus cereus group and Bacillus subtilis by phospholipid extracts analyzed with electrospray ionization tandem mass spectrometry SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Bacilli; electrospray; fatty acids; phospholipids; tandem mass spectrometry; taxonomy ID FATTY-ACIDS; GENUS BACILLUS; ANTHRACIS; THURINGIENSIS; IDENTIFICATION; PREFERENCE; STRAINS; RNA AB Electrospray ionization tandem mass spectrometry (ESI MS-MS) was developed for analysis of bacterial glycerophospholipids and was applied to bacterial differentiation. Bacillus anthracis, B. cereus, B. thuringiensis (referred to as the B. cereus group) and B. subtilis are four closely related members of the Bacillus genus. Conventional taxonomic methods, as well as whole cell carbohydrate profiling and fatty acid profiling are sufficient to differentiate between the B. cereus group and B. subtilis. Phospholipids are the main source of fatty acids in the bacterial cell and therefore should maintain the discriminating power of the fatty acid data. Under negative ionization conditions, phospholipids form predominantly deprotonated molecular ions. The principal bacterial phospholipids detected using negative ion ESI are phosphatidylglycerols (PGs). Chloroform:methanol extraction of whole bacterial cells resulted in ESI mass spectra. The product ion mass spectra of deprotonated PGs provided the molecular weights of the fatty acid moieties. The distribution of fatty acids for the different PG species, as well as the different profiles of PGs, allowed differentiation between the B. cereus group and B. subtilis and this could provide a chemotaxonomic method for bacterial differentiation. (C) 1997 Elsevier Science B.V. C1 GEOCENTERS INC,GUNPOWDER BRANCH,ABERDEEN PROVING GROUND,MD 21010. RP Black, GE (reprint author), USA,CTR DEV & ENGN,EDGEWOOD RES,ABERDEEN PROVING GROUND,MD 21010, USA. NR 27 TC 27 Z9 27 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 J9 J MICROBIOL METH JI J. Microbiol. Methods PD MAR PY 1997 VL 28 IS 3 BP 187 EP 199 DI 10.1016/S0167-7012(97)00980-9 PG 13 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA XC357 UT WOS:A1997XC35700004 ER PT J AU Vorontsov, MA Karpov, AY AF Vorontsov, MA Karpov, AY TI Stimulated optical patterns in a Kerr slice-feedback mirror-type experiment SO JOURNAL OF MODERN OPTICS LA English DT Article ID SYSTEMS; CAVITY AB Transverse optical patterns originating from nonlinear interactions between inserted image spatial modes and self-induced modes in a passive nonlinear system are considered. Experimentally observed stimulated patterns, together with results of numerical simulation and mode amplitude equation analysis, are presented. C1 NEW MEXICO STATE UNIV,LAS CRUCES,NM 88003. RP Vorontsov, MA (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 13 TC 6 Z9 6 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0950-0340 J9 J MOD OPTIC JI J. Mod. Opt. PD MAR PY 1997 VL 44 IS 3 BP 439 EP 446 PG 8 WC Optics SC Optics GA WP072 UT WOS:A1997WP07200001 ER PT J AU Lieberman, HR Askew, EW Hoyt, RW ShukittHale, B Sharp, MA AF Lieberman, HR Askew, EW Hoyt, RW ShukittHale, B Sharp, MA TI Effects of 30 days of undernutrition on plasma neurotransmitter precursors, other amino acids, and behavior SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY LA English DT Article DE diet; tyrosine; tryptophan; performance; malnutrition; gluconeogenesis ID HYPOTENSIVE RATS; BLOOD-PRESSURE; TYROSINE; TRYPTOPHAN; STRESS; BRAIN; PERFORMANCE; METABOLISM; PROTEIN; DIETS AB As part of a 30-day field exercise, 17 soldiers consumed a calorie-deficient, lightweight ration (1946 kcal/day) while 17 others consumed a calorie-adequate control ration (2782 kcal/day). Mean energy expenditure for both groups was 3200 to 3300 kcal/day. Plasma amino acid !el eis Mere assessed at the start, after 14 days, and at the completion of the study. Behavioral resting was conducted at the stars and completion of the study. Alanine, which is used for gluconeogenesis, fell from 389 to 323 nmol/mL over the trial among those who consumed the calorie-deficient diet, whereas it increased in the control group. Plasma tyrosine also fell significantly, from 70 to 52 nmol/mL, as did tryptophan (from 62 to 55 nmol/mL) in the calorie deficient group. The ratio of tyrosine to other large neutral amino acids, an indicator of tyrosine transport to the brain, also fell in the deficient group (from 0.104 to 0.084). At the completion of the study, plasma tryptophan ratio was significantly lower in the calorie deficient group (0.091) compared with the control group (0.103). Decrements in tryptophan, but not tyrosine, ratio were associated with impairments ill simple and choice visual reaction time (r = -0.4415, P = 0.009; r = -0.4029, P = 0.018, respectively). Therefore, changes in plasma amino acids occurring during a controlled form of undernutrition can be substantial; some of these alterations may be related to the functional consequences of undernutrition. (C) Elsevier Science Inc. RP Lieberman, HR (reprint author), USA,ENVIRONM MED RES INST,KANSAS ST,NATICK,MA 01760, USA. NR 47 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0955-2863 J9 J NUTR BIOCHEM JI J. Nutr. Biochem. PD MAR PY 1997 VL 8 IS 3 BP 119 EP 126 DI 10.1016/S0955-2863(97)00008-9 PG 8 WC Biochemistry & Molecular Biology; Nutrition & Dietetics SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA WX897 UT WOS:A1997WX89700003 ER PT J AU Scoville, CR Arciero, RA Taylor, DC Stoneman, PD AF Scoville, CR Arciero, RA Taylor, DC Stoneman, PD TI End range eccentric antagonist concentric agonist strength ratios: A new perspective in shoulder strength assessment SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article; Proceedings Paper CT 36th Annual Society of Military Orthopedic Surgeons Meeting CY NOV 13-15, 1994 CL HILTON HEAD ISL, SC SP Ann Soc Military Ortho Surg DE shoulder; muscle; dynamic strength ID ISOKINETIC EVALUATION; ROTATIONAL STRENGTH; BASEBALL PITCHERS; PLAYERS; PLANE AB The dynamic muscle stabilizers of the shoulder are critical to high performance in the overhead athlete. Previous evaluations of shoulder strength have focused on the concentric strength of the rotator cuff. Functionally, the rotator cuff muscles interact in an eccentric/concentric fashion. This is the first study to evaluate the end range eccentric antagonist/concentric agonist ratios of the shoulder rotators. Seventy-live asymptomatic college-level males were tested through a range of 20 degrees of lateral rotation to 90 degrees of medial relation using the Kin-Com computer-assisted, hydraulic-resisted, isokinetic dynamometer at a speed of 90 degrees/sec. The end range (60-90 degrees) ratios for the medial rotators functioning eccentrically and lateral rotators functioning concentrically were 2.39:1 and 2.15:1 for the dominant and nondominant shoulders, respectively. End range (10 degrees of lateral rotation-20 degrees of medial rotation) ratios for lateral rotators functioning eccentrically and medial rotators functioning concentrically were 1.08:1 and 1.05:1 for the dominant and nondominant shoulders, respectively. The application of this functional assessment of strength testing results may provide important information in the evaluation of the injured shoulder in the overhead athlete, for prescreening, and to gauge return to sports after injury or surgery. C1 KELLER ARMY COMMUNITY HOSP,USA,JOINT & SOFT TISSUE FELLOWSHIP PROGRAM,W POINT,NY 10996. KELLER ARMY COMMUNITY HOSP,USA,MED CORPS,W POINT,NY 10996. BROOKE ARMY MED CTR,USA,MED SPECIALIST CORPS,SAN ANTONIO,TX. RP Scoville, CR (reprint author), KELLER ARMY COMMUNITY HOSP,USA,SPORTS PHYS THERAPY RESIDENCY PROGRAM,W POINT,NY 10996, USA. NR 22 TC 42 Z9 47 U1 0 U2 3 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAR PY 1997 VL 25 IS 3 BP 203 EP 207 PG 5 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA WK050 UT WOS:A1997WK05000006 PM 9048326 ER PT J AU Ward, TP Thach, AB Madigan, WP Berland, JE AF Ward, TP Thach, AB Madigan, WP Berland, JE TI Magnetic resonance imaging in posttraumatic strabismus SO JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS LA English DT Article ID EXTRAOCULAR-MUSCLES; TRAUMA; PALSY RP Ward, TP (reprint author), WALTER REED ARMY MED CTR,OPHTHALMOL SERV,WASHINGTON,DC 20307, USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0191-3913 J9 J PEDIAT OPHTH STRAB JI J. Pediatr. Ophthalmol. Strabismus. PD MAR-APR PY 1997 VL 34 IS 2 BP 131 EP 134 PG 4 WC Ophthalmology; Pediatrics SC Ophthalmology; Pediatrics GA WP011 UT WOS:A1997WP01100016 PM 9083964 ER PT J AU Olson, LL Pick, J Ellis, WY Lim, P AF Olson, LL Pick, J Ellis, WY Lim, P TI A chemical assessment and HPLC assay validation of bulk paromomycin sulfate SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS LA English DT Article DE HPLC; paromomycin sulfate; post-column derivatization; chemical composition ID AMINOGLYCOSIDE ANTIBIOTICS AB This paper describes the compositional analyses of four paromomycin sulfate samples and features a validated HPLC assay method that relies on the fluorescence detection of isoindole derivatives of paromomycin, formed by post-column reaction with o-phthalaldehyde and 2-mercaptoethanol. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CHEM INFORMAT,WASHINGTON,DC 20307. RP Olson, LL (reprint author), SRI INT,DIV LIFE SCI,333 RAVENSWOOD AVE,MENLO PK,CA 94025, USA. NR 11 TC 12 Z9 12 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0731-7085 J9 J PHARMACEUT BIOMED JI J. Pharm. Biomed. Anal. PD MAR PY 1997 VL 15 IS 6 BP 783 EP 793 DI 10.1016/S0731-7085(96)01902-4 PG 11 WC Chemistry, Analytical; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA WW960 UT WOS:A1997WW96000011 PM 9172104 ER PT J AU Marino, MT Urquhart, MR Sperry, ML VonBredow, J Brown, LD Lin, E Brewer, TG AF Marino, MT Urquhart, MR Sperry, ML VonBredow, J Brown, LD Lin, E Brewer, TG TI Pharmacokinetics and kinetic-dynamic modelling of aminophenones as methaemoglobin formers SO JOURNAL OF PHARMACY AND PHARMACOLOGY LA English DT Article ID P-AMINOPROPIOPHENONE; METHEMOGLOBIN; CYANIDE; 4-AMINOPROPIOPHENONE; OXYHEMOGLOBIN AB Methaemoglobin, the oxidized form of haemoglobin, can be formed by a variety of agents, most of which act to oxidize haemoglobin directly or indirectly. Cyanide has a higher affinity for methaemoglobin than for mitochondrial cytochromes, making methaemoglobin formation a basis for the treatment of cyanide poisoning. We used the beagle dog model to investigate the relationship between drug concentration and methaemoglobin levels for two candidate anti-cyanide compounds. The compounds studied were the aminophenones p-aminopropiophenone (PAPP) and p-aminoheptylphenone (PAHP). Both PAPP and PAHP were given as intravenous boluses and as two different oral formulations. The kinetics of both compounds appeared to follow a three-compartment open model for intravenous bolus administration and a two-compartment open model for oral administration. The first distribution phase seen with the intravenous administration was obscured by the absorption phase during oral administration. Bioavailability for all formulations varied between 20 and 47%. For both compounds there was a delay between the appearance of drug in the plasma and the appearance of methaemoglobin (counter-clockwise hysteresis) which is suggestive of an active metabolite causing methaemoglobin formation. The pharmacodynamics were fit with an effect-compartment kinetic-dynamic model linked to a sigmoid E(max) pharmacodynamic model. Maximum amounts of methaemoglobin occurred between 2 and 4 h for PAHP and between 1 and 3 h for PAPP. When administered intravenously estimates of EC50 were lower than the estimates of EC50 from oral administration for both compounds. This might be because of oral first-pass inactivation or a 'first-pass' activation through the lungs contributing to the formation of an active metabolite. The phenones as a class appear to have the drug cleared and methaemoglobin return to near baseline within 12 h. Both compounds seem to produce sufficient methaemoglobin to treat acute cyanide poisoning and to serve as prophylactic agents against acute cyanide poisoning in a military setting. C1 UNIV CALIF SAN FRANCISCO,SCH PHARM,DEPT PHARM,SAN FRANCISCO,CA 94143. RP Marino, MT (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPT THERAPEUT,WASHINGTON,DC 20307, USA. NR 29 TC 5 Z9 5 U1 0 U2 4 PU ROYAL PHARMACEUTICAL SOC GREAT BRITAIN PI LONDON PA 1 LAMBETH HIGH ST, LONDON, ENGLAND SE1 7JN SN 0022-3573 J9 J PHARM PHARMACOL JI J. Pharm. Pharmacol. PD MAR PY 1997 VL 49 IS 3 BP 282 EP 287 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA WR274 UT WOS:A1997WR27400011 PM 9231346 ER PT J AU Burke, LW Irwin, ES Faulstich, R Newnham, CE Scholey, N AF Burke, LW Irwin, ES Faulstich, R Newnham, CE Scholey, N TI High-g power sources for the US Army's HSTSS programme SO JOURNAL OF POWER SOURCES LA English DT Article; Proceedings Paper CT 20th International Power Sources Symposium on Research and Development in Non-Mechanical Electrical Power Sources CY APR 21-23, 1997 CL BRIGHTON, ENGLAND SP Int Power Sources Symp Ltd DE lithium-ion secondary batteries; applications, weapons AB Under the Hardened Subminiature Telemetry and Sensor System (HSTSS) programme, the US Army has been developing gun-hardened telemetry devices and subsystems for the testing of smart weapon systems. These devices will be able to withstand accelerations in excess of 100 000 g and radial accelerations in excess of 25 000 g. Under this programme, rechargeable lithium-ion polymer battery technology and primary lithium/manganese dioxide technology are being developed for ballistic telemetry applications. To date, prototypes of these batteries have survived accelerations well over 100 000 g. This report provides the current status of these developments and reviews battery designs and testing regimes. C1 TEST & EVALUAT COMMAND,YUMA PROVING GROUNDS,AZ 85365. ULTRALIFE BATTERIES UK LTD,ABINGDON OX14 1TG,OXON,ENGLAND. RP Burke, LW (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 9 TC 1 Z9 5 U1 0 U2 6 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD MAR-APR PY 1997 VL 65 IS 1-2 BP 263 EP 270 DI 10.1016/S0378-7753(96)02619-5 PG 8 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA XE950 UT WOS:A1997XE95000042 ER PT J AU Bowen, GL Orthner, DK Bell, DB AF Bowen, GL Orthner, DK Bell, DB TI Differences in spouses' perceptions of family adaptation SO JOURNAL OF SOCIAL BEHAVIOR AND PERSONALITY LA English DT Article ID WORK; MEMBERS; PARENTS AB This article examines the potential predictive validity of creating a couple measure of family adaptation from the individual survey responses of husbands and wives. The analysis is based on the responses of 2,729 married couples who participated in the 1989 Army Soldier and Family Survey. Family adaptation includes both an internal component and an external component. It is defined as an outcome of the family's efforts to cope and adjust in meeting the individual and collective needs of its members and in responding to external demands. Spouses' perceptions of their internal and external family adaptation are significantly related to their own work and personal adjustments. Yet, the results suggest that the family adaptation of the spouse offers little or no additional direct contribution to understanding the work and personal adjustments of the other spouse once their own level of adaptation is taken into account. It is concluded that little justification exists for a couple measure of family adaptation in the absence of a theoretical rationale. C1 USA,RES INST,ALEXANDRIA,VA 22333. RP Bowen, GL (reprint author), UNIV N CAROLINA,SCH SOCIAL WORK,301 PITTSBORO ST,CHAPEL HILL,NC 27599, USA. NR 38 TC 4 Z9 4 U1 1 U2 1 PU SELECT PRESS PI CORTE MADERA PA PO BOX 37, CORTE MADERA, CA 94976 SN 0886-1641 J9 J SOC BEHAV PERS JI J. Soc. Behav. Pers. PD MAR PY 1997 VL 12 IS 1 BP 53 EP 72 PG 20 WC Psychology, Social SC Psychology GA WT048 UT WOS:A1997WT04800006 ER PT J AU Schmidt, EM AF Schmidt, EM TI Aerodynamic considerations for kinetic energy projectiles SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article RP Schmidt, EM (reprint author), USA,RES LAB,ARMY ELECT ARMAMNET PROGRAM,WEAP & MAT RES DIV,ABERDEEN PROVING GROUND,MD 21005, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD MAR-APR PY 1997 VL 34 IS 2 BP 261 EP 262 PG 2 WC Engineering, Aerospace SC Engineering GA WT011 UT WOS:A1997WT01100021 ER PT J AU Sprenger, D AF Sprenger, D TI Sertraline for nocturnal enuresis SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY LA English DT Letter RP Sprenger, D (reprint author), EISENHOWER ARMY MED CTR,FT GORDON,GA, USA. NR 5 TC 12 Z9 12 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0890-8567 J9 J AM ACAD CHILD PSY JI J. Am. Acad. Child Adolesc. Psychiatr. PD MAR PY 1997 VL 36 IS 3 BP 304 EP 305 DI 10.1097/00004583-199703000-00006 PG 2 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA WK274 UT WOS:A1997WK27400006 PM 9055508 ER PT J AU Anderson, LL Welch, ML Grabski, WJ AF Anderson, LL Welch, ML Grabski, WJ TI Allergic contact dermatitis and reactivation phenomenon from iontophoresis of 5-fluorouracil SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID CHEMOTHERAPY; TOXICITY; SKIN RP Anderson, LL (reprint author), BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 11 TC 6 Z9 6 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAR PY 1997 VL 36 IS 3 BP 478 EP 479 DI 10.1016/S0190-9622(97)80232-0 PN 1 PG 2 WC Dermatology SC Dermatology GA WM433 UT WOS:A1997WM43300021 PM 9091485 ER PT J AU Warren, WL Tuttle, BA Rong, FC Gerardi, GJ Poindexter, EH AF Warren, WL Tuttle, BA Rong, FC Gerardi, GJ Poindexter, EH TI Electron paramagnetic resonance investigation of acceptor centers in Pb(Zr,Ti)O-3 ceramics SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID FERROELECTRIC THIN-FILMS; SPIN-RESONANCE; BATIO3; TRANSITION; ZEOLITES; DEFECTS; STATES; ESR AB The nature of extrinsic point defects in lead zirconate titanate (PZT) ceramics of various compositions prepared by solution chemistry has been explored. Using electron paramagnetic resonance (EPR), several impurity sites have been identified in the as-received materials, which include FE(3+)-oxygen vacancy (V-O(..)) complier and isolated Cu2+ ions; both of these ions are incorporated into the lattice by replacing the Ti (Zr) ion. A Fe3+-V-O(..) complex serves as a sensitive probe of the local crystalline field environment of the ceramic; the symmetry of this defect is roughly correlated with its phase diagram as the composition is varied from PbTiO3 to PbZrO3. The Fe3+-V-O(..) complex experiences tetragonal, rhombic, or orthorhombic symmetry as the composition is varied from PbTiO, to PbZrO3. As the composition of the Cu2+ ion is varied, it appears as though the addition of Zr, and nor necessarily a change in phase, is largely responsible in determining the local environment of this acceptor impurity. Also, the Cu2+ resonance parameters weakly reflect the relative Ti-O (Zr-O) bond covalency in the perovskite lattice. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP Warren, WL (reprint author), SANDIA NATL LABS,POB 5800,ALBUQUERQUE,NM 87185, USA. NR 45 TC 37 Z9 37 U1 0 U2 11 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD MAR PY 1997 VL 80 IS 3 BP 680 EP 684 PG 5 WC Materials Science, Ceramics SC Materials Science GA WQ570 UT WOS:A1997WQ57000021 ER PT J AU Warber, JP AF Warber, JP TI In defense of dietary fiber - Reply SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION LA English DT Letter RP Warber, JP (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER DIETETIC ASSOC PI CHICAGO PA 216 W JACKSON BLVD #800, CHICAGO, IL 60606-6995 SN 0002-8223 J9 J AM DIET ASSOC JI J. Am. Diet. Assoc. PD MAR PY 1997 VL 97 IS 3 BP 248 EP 248 PG 1 WC Nutrition & Dietetics SC Nutrition & Dietetics GA WL797 UT WOS:A1997WL79700003 ER PT J AU Edman, J Kittayapong, P Linthicum, K Scott, T AF Edman, J Kittayapong, P Linthicum, K Scott, T TI Attractant resting boxes for rapid collection and surveillance of Aedes aegypti (L) inside houses SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID IMPREGNATED BEDNETS; CULICIDAE; DIPTERA; BLOOD AB Three different resting station designs made of cardboard covered with black cloth were evaluated for their attractiveness to Aedes aegypti populations resting inside houses in Thailand. Box designs attracted more females (but not males) than an open-panel design. Thirty to 60% of all adult Ae, aegypti resting inside houses were collected by aspirating from 2-4 resting boxes placed inside houses. Tall boxes (90 cm) did not attract more females or males than short boxes (45 cm). Forty-two percent more females (but fewer males) were attracted to boxes when oviposition bowls were placed inside the boxes. Four boxes per house attracted 32% more mosquitoes than two boxes. Aspirating from artificial resting stations is an efficient and rapid method for sampling male and teneral, bloodfed, and gravid female Ae. aegypti resting inside houses. C1 MAHIDOL UNIV,DEPT BIOL,BANGKOK 10400,THAILAND. UNIV CALIF DAVIS,DEPT ENTOMOL,DAVIS,CA 95616. ARMED FORCES RES INST MED SCI,DEPT ENTOMOL,BANGKOK 10400,THAILAND. RP Edman, J (reprint author), UNIV MASSACHUSETTS,DEPT ENTOMOL,FERNALD HALL,AMHERST,MA 01003, USA. FU NIAID NIH HHS [AI-22119] NR 15 TC 28 Z9 28 U1 0 U2 4 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1997 VL 13 IS 1 BP 24 EP 27 PG 4 WC Entomology SC Entomology GA WY839 UT WOS:A1997WY83900005 PM 9152871 ER PT J AU Horosko, S Lima, JBP Brandolini, MB AF Horosko, S Lima, JBP Brandolini, MB TI Establishment of a free-mating colony of Anopheles albitarsis from Brazil SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article AB The establishment of a free-mating colony of Anopheles albitarsis sensu stricto, a member of the Anopheles albitarsis complex, is described. Groups of females from the F-5, F-6, and F-11 generations were examined, and the percent inseminated, mean number of eggs oviposited and percent hatch discussed. The colony has been continued through 18 generations, with larval development averaging IO days, and larval mortality ranging between 20 and 30%. C1 INST BIOL EXERCITO,BR-20911270 RIO JANEIRO,BRAZIL. RP Horosko, S (reprint author), USA,MED RES UNIT BRAZIL,AMER CONSULATE RIO,APO,AA 34030, USA. NR 10 TC 18 Z9 19 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1997 VL 13 IS 1 BP 95 EP 96 PG 2 WC Entomology SC Entomology GA WY839 UT WOS:A1997WY83900018 PM 9152884 ER PT J AU Wong, N AF Wong, N TI Psychoanalytic group theory and therapy: Essays in honor of Saul Scheidlinger - Tuttman,S SO JOURNAL OF THE AMERICAN PSYCHOANALYTIC ASSOCIATION LA English DT Book Review C1 WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC. NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER PSYCHOANALYTIC ASSOC PI NEW YORK PA 309 E 49TH ST, NEW YORK, NY 10017 SN 0003-0651 J9 J AM PSYCHOANAL ASS JI J. Am. Psychoanal. Assoc. PD SPR PY 1997 VL 45 IS 2 BP 640 EP 644 DI 10.1177/00030651970450020302 PG 5 WC Psychiatry; Psychology, Psychoanalysis SC Psychiatry; Psychology GA XL312 UT WOS:A1997XL31200034 ER PT J AU Yang, YC Berg, FJ Szafraniec, LL Beaudry, WT Bunton, CA Kumar, A AF Yang, YC Berg, FJ Szafraniec, LL Beaudry, WT Bunton, CA Kumar, A TI Peroxyhydrolysis of nerve agent VX and model compounds and related nucleophilic reactions. SO JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 LA English DT Article ID TRANSITION-STATE; PHOSPHATE-ESTERS; HYDROGEN-PEROXIDE; AQUEOUS-SOLUTION; HYDROXIDE ION; REACTIVITY; HYDROLYSIS; CLEAVAGE; ANION; DEPHOSPHORYLATION AB The exceedingly toxic agent VX [O-ethyl S-(diisopropylaminoethyl) methylphosphonothioate], 1a, and the midly toxic model compound, O,S-diethyl methylphosphonothioate, Ib, react with HO- to give parallel P-S and P-O bond cleavages; the P-O cleavage of VX produces relatively unreactive but very toxic anionic phosphonothioate. Peroxyhydrolysis of 1a,b with HO2- involves quantitative P-S cleavage at rates 30-40 times that with HO- giving the corresponding phosphonate and sulfonate ions and disulfide as nontoxic products, In reaction of 1b with HO2- in H-2 O-18, oxygen in these final products is not derived from water and HO2- exclusively displaces the thiolate ion at phosphorus, Reaction of Ib with HSO5- gives the same products, but via oxidatively promoted attack of H-2 O-18 on phosphorus; Kinetic and isotopic labelling results on reactions of la,b and a range of related compounds with HO2-, HO- and RO(-) and an oximate ion are interpreted in terms of concerted S(N)2(P) reactions rather than stepwise reactions with formation of a trigonal bipyramidal (TBP) intermediate. Product selectivity depends on the relative basicities of the anionic nucleophile and the leaving anions. C1 UNIV CALIF SANTA BARBARA, DEPT CHEM, SANTA BARBARA, CA 93106 USA. RP USA, ERDEC, RES & TECHNOL DIRECTORATE, ABERDEEN PROVING GROUND, MD 21010 USA. NR 55 TC 77 Z9 78 U1 2 U2 5 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1472-779X J9 J CHEM SOC PERK T 2 JI J. Chem. Soc.-Perkin Trans. 2 PD MAR PY 1997 IS 3 BP 607 EP 613 DI 10.1039/a604671a PG 7 WC Chemistry, Organic; Chemistry, Physical SC Chemistry GA WN481 UT WOS:A1997WN48100035 ER PT J AU Galbicka, G AF Galbicka, G TI In today's climate, a forecast for change: A commentary on Donahoe, Palmer, and Burgos SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR LA English DT Editorial Material ID BEHAVIOR; SCHEDULES; SHOCK RP Galbicka, G (reprint author), WALTER REED ARMY INST RES,DIV NEUROSCI,WASHINGTON,DC 20307, USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU SOC EXP ANALYSIS BEHAVIOR INC PI BLOOMINGTON PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 SN 0022-5002 J9 J EXP ANAL BEHAV JI J. Exp. Anal. Behav. PD MAR PY 1997 VL 67 IS 2 BP 220 EP 223 DI 10.1901/jeab.1997.67-220 PG 4 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental SC Psychology; Behavioral Sciences GA WP061 UT WOS:A1997WP06100007 PM 16812836 ER PT J AU Connon, WH AF Connon, WH TI The origin of the composite wheeled vehicle, two-wheeled trailer, and tracked vehicle vibration schedules in MIL-STD-810D/E SO JOURNAL OF THE INSTITUTE OF ENVIRONMENTAL SCIENCES LA English DT Article; Proceedings Paper CT 42nd Annual Technical Meeting of the Institute-of-Environmental-Sciences CY MAY, 1996 CL ORLANDO, FL SP Inst Environm Sci DE MIL-STD-810D/E; laboratory vibration schedules; vibration testing; ground vehicle vibration AB In the early and mid-1980s, a concerted effort was made at the Aberdeen Test Center (then Combat Systems Test Activity) to collect vibration data on a wide variety of vehicles to create laboratory vibration test schedules. The initial schedules were published in MIL-STD-810D and were updated for publication in MIL-STD-810E and ITOP (Inter-national Test Operations Procedure) 1-2-601. Although the vehicles used for schedule development are listed in the documents and a rest scenario is described, little information has been published describing how the test levels compare with the actual measured levels and how the test courses used compare with the terrain likely to be encountered in the vehicle's normal operation. This paper describes the data acquisition and analysis efforts to show where and how measurements were made and how the final test levels relate to the actual measured levels. It will also describe the rest courses used and show how they relate to ''civilian sector'' conditions such as operation on an unpaved road. The purpose of the paper is to provide an understanding of the physical severity represented by the test procedures used and the amount of conservatism and level exaggeration (to reduce test time) built into the schedule development process. RP Connon, WH (reprint author), USA,ABERDEEN TEST CTR,ABERDEEN PROVING GROUND,MD 21005, USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU INST ENVIRONMENTAL SCI PI MT PROSPECT PA 940 E NORTHWEST HIGHWAY, MT PROSPECT, IL 60056 SN 1052-2883 J9 J INST ENVIRON SCI JI J. Inst. Environ. Sci. PD MAR-APR PY 1997 VL 40 IS 2 BP 31 EP 37 PG 7 WC Engineering, Environmental; Environmental Sciences; Instruments & Instrumentation SC Engineering; Environmental Sciences & Ecology; Instruments & Instrumentation GA WX580 UT WOS:A1997WX58000003 ER PT J AU Chandra, AMS Qualls, CW Reddy, G AF Chandra, AMS Qualls, CW Reddy, G TI Testicular effects of 1,3,5-trinitrobenzene (TNB) .1. Dose response and reversibility studies SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH LA English DT Article ID LONG-TERM SEQUELAE; MALE REPRODUCTION; FISCHER-344 RATS; TOXICITY; 1,3-DINITROBENZENE; METABOLISM AB Testicular effects of TNB were characterized after single and multiple oral doses of TNB at 0, 35.5, and 71 mg/kg. Male Fischer 344 (F344) rats were killed after a single dose or after 4 and 10 daily doses of TNB. Testicular effects were not evident at the light microscope level in rats killed after a single dose of TNB or after 4 daily doses at 35.5 mg/kg of TNB. Rats receiving 4 daily doses of TNB at 71 mg/kg had the earliest evidence of testicular damage, with necrosis and degeneration of pachytene spermatocytes including a significant decrease in testicular weight. Rats dosed at 35.5 mg/kg for 10 d had severe testicular lesions, in addition to the decrease in testicular weight. There was degeneration of round and elongate spermatids, and formation of multinucleate syncytial cells. The epididymis was devoid of sperm, instead containing exfoliated syncytial spermatids. Rats dosed at 71 mg/kg of TNB for 10 d had testicular atrophy and cessation of spermatogenesis. These rats also had apoptic cells in the ventral prostate. To assess the extent of reversibility in these atrophied testis, rats were allowed to recover for 10 or 30 d after 10 doses of TNB (71 mg/kg). A significant regenerative attempt with proliferating spermatocytes were present at 10 d and elongate spermatids were evident at 30 d. These reversibility studies indicate testicular effects of TNB are at least partially reversible. C1 OKLAHOMA STATE UNIV,COLL VET MED,DEPT VET PATHOL,STILLWATER,OK 74078. USA,CTR HLTH PROMOT & PREVENT MED,ABERDEEN PROVING GROUND,MD. NR 35 TC 8 Z9 8 U1 0 U2 1 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0098-4108 J9 J TOXICOL ENV HEALTH JI J. Toxicol. Environ. Health PD MAR PY 1997 VL 50 IS 4 BP 365 EP 378 DI 10.1080/009841097160401 PG 14 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA WP897 UT WOS:A1997WP89700002 PM 9120873 ER PT J AU Chandra, AMS Qualls, CW Campbell, GA Reddy, G AF Chandra, AMS Qualls, CW Campbell, GA Reddy, G TI Testicular effects of 1,3,5-trinitrobenzene (TNB) .2. Immunolocalization of germ cells using proliferating cell nuclear antigen (PCNA) as an endogenous marker SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH LA English DT Article ID HEPATOCELLULAR PROLIFERATION; MONOCLONAL-ANTIBODY; ENHANCEMENT METHOD; RAT-LIVER; LOCALIZATION; PROTEIN; TISSUES; RODENT; CYCLE AB The applicability of PCNA as a tool for the analysis of germ cells in rats treated with 1,3,5-trinitrobenzene (TNB), a potent testicular toxicant, was evaluated. Male Fischer 344 (F344) rats were gavaged with TNB at 71 mg/kg or with corn oil (vehicle). Rats were killed after 10 daily oral doses or were allowed to recover for 10 or 30 d after the 10 doses. Testes from control rats, treated rats, and rats allowed to recover were immunohistochemically stained for PCNA. PCNA labeling in the control rats was confined to the nuclei of spermatogonia, pachytene spermatocytes, and nuclei of elongate spermatocytes. Conventional (hematoxylin and eosin) staining of testes from rats treated with TNB at 71 mg/kg for 10 d revealed loss of germ cells and cessation of spermatogenesis. Immuno-histochemical staining of sections from these treated rats revealed only PCNA-positive spermatogonia. Rats allowed a 10-d recovery had both spermatogonial and spermatocytic staining, indicating partial restoration of germ-cell population. In rats allowed to recover for 30 d, the PCNA staining pattern was identical to the control rats. These results indicate that PCNA can be used to assess the proliferative status of spermatogonia (germ cells) in rodent testes exposed to testicular toxicants. C1 OKLAHOMA STATE UNIV,COLL VET MED,DEPT VET PATHOL,STILLWATER,OK 74078. USA,CTR HLTH PROMOT & PREVENT MED,ABERDEEN PROVING GROUND,MD. NR 23 TC 7 Z9 7 U1 0 U2 1 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0098-4108 J9 J TOXICOL ENV HEALTH JI J. Toxicol. Environ. Health PD MAR PY 1997 VL 50 IS 4 BP 379 EP 387 DI 10.1080/009841097160410 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA WP897 UT WOS:A1997WP89700003 PM 9120874 ER PT J AU Moul, JW AF Moul, JW TI Prospective evaluation of prostate specific antigen and prostate specific antigen density in the detection of carcinoma of the prostate: Ethnic variations - Editorial comment SO JOURNAL OF UROLOGY LA English DT Editorial Material C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP Moul, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,CTR PROSTATE DIS RES,BETHESDA,MD 20814, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAR PY 1997 VL 157 IS 3 BP 911 EP 912 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA WG214 UT WOS:A1997WG21400045 ER PT J AU Thompson, IM AF Thompson, IM TI Prostate cancer SO JOURNAL OF UROLOGY LA English DT Editorial Material RP Thompson, IM (reprint author), BROOKE ARMY MED CTR,DEPT SURG,SAN ANTONIO,TX 78234, USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAR PY 1997 VL 157 IS 3 BP 919 EP 920 DI 10.1016/S0022-5347(01)65083-3 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA WG214 UT WOS:A1997WG21400047 PM 9072599 ER PT J AU McDonald, RA Mayers, DL Chung, RCY Wagner, KF RattoKim, S Birx, DL Michael, NL AF McDonald, RA Mayers, DL Chung, RCY Wagner, KF RattoKim, S Birx, DL Michael, NL TI Evolution of human immunodeficiency virus type 1 env sequence variation in patients with diverse rates of disease progression and T-cell function SO JOURNAL OF VIROLOGY LA English DT Article ID NUCLEOTIDE SUBSTITUTIONS; GENETIC-VARIATION; HIV-1 INFECTION; HTLV-III; IN-VIVO; AIDS; TRANSMISSION; PATHOGENESIS; INFANTS; INVIVO AB We examined the relationship between env sequence variation and disease progression in 10 human immunodeficiency virus type 1 (HIV-1)-seropositive subjects selected from a longitudinal cohort receiving zidovudine therapy. Five subjects were chosen for stable clinical status and CD4 counts (slow progressors), and five were selected for rapid clinical deterioration and CD4 count decline (rapid progressors). The slow progressors had significantly lower plasma viral RNA loads and greater lymphoproliferative responses to mitogens than the rapid progressors. DNA sequences representing the C1 through C3 regions of env were amplified from two peripheral blood mononuclear cell DNA samples from each subject separated by an average of 2.5 years. Molecular clones of these amplicons were then sequenced, and DNA sequence and deduced amino acid sequence distances were compared. Inter-time point sequence comparison showed a higher rate of sequence evolution for the rapid progressors in three of five matched pairs of rapid progressors and slow progressors and for the slow progressors in the remaining two subject pairs. However, intra-time point sequence comparisons showed that four of five slow progressors developed a more diverse quasispecies over time and one showed no change. In contrast, four of five rapid progressors showed no change in quasispecies diversity over time and one showed a significant decrease in diversity. The overall C1 through C3 region quasispecies diversity in the slow progressors at baseline was lower than that for the rapid progressors, but this difference was not significant at the follow-up time points. These diversity relationships were obscured if sequence analyses were limited to the 300-bp C2 to V3 region. Thus, HIV-1 quasispecies diversity increased over time in subjects with more functional immune systems. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. HENRY M JACKSON FDN,ROCKVILLE,MD. WALTER REED ARMY MED CTR,DIV INFECT DIS,WASHINGTON,DC 20307. NR 40 TC 43 Z9 43 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD MAR PY 1997 VL 71 IS 3 BP 1871 EP 1879 PG 9 WC Virology SC Virology GA WH172 UT WOS:A1997WH17200016 PM 9032317 ER PT J AU Lebeda, FJ AF Lebeda, FJ TI Deterrence of biological and chemical warfare: A review of policy options SO MILITARY MEDICINE LA English DT Article ID DEFENSE RESEARCH-PROGRAM; WEAPONS CONVENTION; MEDICAL BENEFITS; CHALLENGES; LESSONS; NEED AB The deployment of biological and chemical weapons by aggressor states is not a hypothetical scenario but a life-threatening contingency, Although Iraq was deterred from using its biological and chemical weapons during Operation Desert Storm, what forms of deterrence must be considered in preventing the use of these weapons of mass destruction in the future? Traditional deterrents against their use have ranged from the threat of a military response to the ratification of diplomatic treaties and agreements, An overall strategy to deter the use of these weapons includes an additional, less frequently discussed approach-force protection-which encompasses defensive biomedical countermeasures (e.g., antibiotics, drugs, vaccines, diagnostic tests) and nonmedical protective devices (e.g., masks, specialized clothing/shelters, detectors), A combined, integrated approach to deterrence is reviewed in this article with regard to current policies and the roles played by Department of Defense research and development programs for biological and chemical defense. RP Lebeda, FJ (reprint author), USA,MED RES INST INFECT DIS,DEPT BIOCHEM & CELL BIOL,DIV TOXICOL,FREDERICK,MD 21702, USA. NR 68 TC 9 Z9 9 U1 1 U2 4 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1997 VL 162 IS 3 BP 156 EP 161 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA WP113 UT WOS:A1997WP11300005 PM 9121658 ER PT J AU Craig, SC Morgan, J AF Craig, SC Morgan, J TI Parachuting injury surveillance, Fort Bragg, North Carolina, May 1993 to December 1994 SO MILITARY MEDICINE LA English DT Article AB Surveillance for parachute-related injuries was conducted at Fort Bragg, North Carolina, between May 1993 and December 1994, During this 20-month period, lower-extremity injuries (27% of all injuries), axial skeletal (back and neck) strains and sprains (19.3%), and closed head injuries (18.4%) were the leading causes of injury, The incidence of injuries requiring emergency care was 8/1,000 jumps, This rate is well within the jump injury planning estimate, suggesting that airborne training and operations are conducted in a safe and effective manner at Fort Bragg. RP Craig, SC (reprint author), USA,EPIDEMIOL PROGRAM BRANCH,CTR HLTH PROMOT WELLNESS & PREVENT MED,ABERDEEN PROVING GROUND,MD 21045, USA. NR 1 TC 25 Z9 27 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1997 VL 162 IS 3 BP 162 EP 164 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA WP113 UT WOS:A1997WP11300006 PM 9121659 ER PT J AU Sentell, JW Lacroix, M Sentell, JV Finstuen, K AF Sentell, JW Lacroix, M Sentell, JV Finstuen, K TI Predictive patterns of suicidal behavior: The United States armed services versus the civilian population SO MILITARY MEDICINE LA English DT Article ID YOUNG-ADULTS; PREVALENCE; LIFE; RISK; AGE AB Suicide is the eighth leading cause of death in the United States and the third leading cause of death in the military population. The purpose of this study was to compare the suicide rates of the Army, Navy, Marine Corps, and Air Force to the U.S. population for the years 1980 through 1992. Multivariate linear regression analytic techniques were used to test the specific effects of year, service membership, and gender on suicide rates. A hierarchical linear regression equation resulted in R(2) = 0.6737, a highly predictive finding (F-112,F-18 = 13.600, p < 0.000). Further controlled hypothesis testing suggested that each independent variable provided a unique contribution to the total variance accounted for in suicide rates, A follow-on set of time series regressions was used to assess the effects of gender and specific military service on suicide rates over the 13-year period. Findings revealed that suicide rates for civilian males are increasing, whereas civilian female rates are declining, No significant trends by year were shown among the services, Military suicide rates were consistently lower than civilian rates, and military female rates tended to be lower yet than military male rates. RP Sentell, JW (reprint author), USA,BAYLOR UNIV GRAD PROGRAM HLTH CARE ADM,MED DEPT CTR & SCH,FT SAM HOUSTON,TX 78234, USA. NR 22 TC 17 Z9 18 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1997 VL 162 IS 3 BP 168 EP 171 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA WP113 UT WOS:A1997WP11300008 PM 9121661 ER PT J AU Samuels, GL AF Samuels, GL TI Army community health nurses' role in humanitarian relief effort, operation sea signal, Guantanamo Bay, Cuba SO MILITARY MEDICINE LA English DT Article ID MILITARY AB Naval Station, Guantanamo Bay, on the southeast corner of Cuba, became a hard-back tent city, the home of over 50,000 Cuban and Haitian refugees, from July 20, 1994, to January 31, 1996. The talents of members of the U.S. armed forces, combined with government and nongovernment agencies, contributed to what is considered by many the most successful migrant operation ever conducted in the 20th century, Army community health nurses constituted an integral part of this operation, Their hard work and dedicated service contributed, in large part, to the ultimate success of the mission. RP Samuels, GL (reprint author), USA,MED ACT,PREVENT MED SERV,FT CAMPBELL,KY 42223, USA. NR 5 TC 1 Z9 1 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1997 VL 162 IS 3 BP 190 EP 193 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA WP113 UT WOS:A1997WP11300013 PM 9121666 ER PT J AU Friedl, KE Vogel, JA AF Friedl, KE Vogel, JA TI Validity of percent body fat predicted from circumferences: Classification of men for weight control regulations SO MILITARY MEDICINE LA English DT Article ID DISEASE; RISK AB Each of the military services classifies individuals in their weight control programs using percent body fat predicted by circumference-based equations, Although derived independently from service-specific samples, each of the male equations relies on waist circumference adjusted by a neck circumference, In this study, the authors examined the performance of the equations in 496 young (<40 years) male soldiers, compared to percent body fat measured by dual-energy X-ray absorptiometry, The strength of the relationship to percent body fat improved from body mass index (weight/height(2)), to a waist circumference alone, to the difference between waist and neck circumferences. Overweight men who were misclassified by overestimation of total percent body fat using the equations (2.6% of the total sample) had normal neck circumferences and height but large waistlines, indicating that they were still classified appropriately to the goals of the weight control programs, all of which center on abdominal adiposity, The authors demonstrate that each of the service equations yield substantially similar results and discuss why a single equation could be easily agreed to and used by the Department of Defense for male body fat prediction. C1 USA,ENVIRONM MED RES INST,OCCUPAT PHYSIOL DIV,NATICK,MA 01760. OI Friedl, Karl/0000-0002-3134-8427 NR 24 TC 7 Z9 7 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1997 VL 162 IS 3 BP 194 EP 200 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA WP113 UT WOS:A1997WP11300014 PM 9121667 ER PT J AU Kuklo, TR Heekin, RD Temple, HT Islinger, RB Horan, PJ AF Kuklo, TR Heekin, RD Temple, HT Islinger, RB Horan, PJ TI A review of total joint replacement in active duty soldiers SO MILITARY MEDICINE LA English DT Review ID ARTHROPLASTY AB Thirty-two active duty soldiers (36 total joint replacements) were followed from 9 months and 18 years (average 4.1 years) to evaluate the outcome of total joint replacement in active duty soldiers. Follow-up consisted of clinical assessment and radiographic evaluation at 6 weeks, 3 months, 6 months, 1 year, and yearly thereafter. A Harris hip rating (HHR) was also completed at each clinic visit. There were 30 total hip arthroplasties in 27 patients with an average age at surgery of 40.8 years (range 31-58) and an average follow-up of 4.1 years. The HHR averaged 93 on latest evaluation. There were three revisions (average 7.2 years). Of the 27 patients, 18 were retained on active duty and 9 were separated from service. Of the senior enlisted (E7 or above) and officers (O4 or above), 16 of 17 (94%) mere retained on active duty, whereas only 2 of 10 (20%) of the junior enlisted (E6 or below) were retained on active duty. There were 6 total knee arthroplasties in 5 patients with an average age at surgery of 49.8 years (range 33-58) and an average follow-up of 3.0 years (9 months to 4 years). There were no revisions, and all 5 soldiers were retained on active duty. Preliminary results from this study reveal that a high percentage of soldiers undergoing total joint replacement are retained on active duty (72%) and are able to continue active lives. Rank or seniority also appears to be a significant factor for retention on active duty. The revision rate (10%) and the rate of osteolysis (19%) are comparable with reported rates. RP Kuklo, TR (reprint author), WALTER REED ARMY MED CTR,ORTHOPAED SURG SERV,WASHINGTON,DC 20307, USA. NR 16 TC 8 Z9 8 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1997 VL 162 IS 3 BP 201 EP 204 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA WP113 UT WOS:A1997WP11300015 PM 9121668 ER PT J AU Huycke, KA Gambel, JM Petruccelli, BP Wasserman, GM AF Huycke, KA Gambel, JM Petruccelli, BP Wasserman, GM TI Lessons learned from producing health information booklets for deploying US military personnel SO MILITARY MEDICINE LA English DT Article ID READABILITY; AIDS AB Health information booklets deliver information to large groups quickly and economically. Rapidly deploying soldiers are a group that needs such information. Military personnel responsible for the health of troops should know of the materials produced to meet this need so that they can facilitate booklet distribution. The Waiter Reed Army Institute of Research within the U.S. Army Medical Research and Materiel Command has produced health information booklets in support of deployments to Southwest Asia, Somalia, Rwanda, Haiti, and the former Republics of Yugoslavia. This article describes these booklets' content, use during milltary operations, distribution, costs, and benefits. A discussion of lessons learned includes steps to develop and evaluate health information and is followed by an explanation of the current situation. We offer suggestions to improve the booklet development process; our experience may be helpful to others developing health information materials for military personnel or civilians. RP Huycke, KA (reprint author), WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 27 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1997 VL 162 IS 3 BP 209 EP 214 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA WP113 UT WOS:A1997WP11300017 PM 9121670 ER PT J AU Russo, MB Brooks, FR Fontenot, JP Dopler, BM Neely, ET Halliday, AW AF Russo, MB Brooks, FR Fontenot, JP Dopler, BM Neely, ET Halliday, AW TI Sodium pentothal hypnosis: A procedure for evaluating medical patients with suspected psychiatric co-morbidity SO MILITARY MEDICINE LA English DT Article AB The development of psychiatric co-morbidity in medical illness is well known, but distinguishing the functional from the organic is often difficult. This paper describes a procedure using hypnotic doses of sodium pentothal (thiopental) combined with hypnosis to distinguish signs and symptoms of physiologic origin from those of psychiatric origin. Three cases are presented to illustrate the procedure. In the ''Discussion'' the four-phase technique is described, and three criteria are proposed to aid in the selection of patients. The cases presented are of patients who were under evaluation for confirmation of neurologic diagnosis and degree of disability prior to discharge from active military duty. Using the pentothal hypnosis procedure during the re-evaluation, the disabilities were reversed and conversion disorders were diagnosed. RP Russo, MB (reprint author), BROOKE ARMY MED CTR,NEUROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 3 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1997 VL 162 IS 3 BP 215 EP 218 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA WP113 UT WOS:A1997WP11300018 PM 9121671 ER PT J AU Ellenbogen, RG Moores, LE AF Ellenbogen, RG Moores, LE TI Endoscopic management of a pineal and suprasellar germinoma with associated hydrocephalus: Technical case report SO MINIMALLY INVASIVE NEUROSURGERY LA English DT Article DE endoscopy; germinoma; pineal region; hydrocephalus; cine-mode; magnetic resonance imaging ID TUMORS AB A patient with a synchronous pineal and suprasellar germinoma and symptomatic hydrocephalus underwent a minimally invasive endoscopic biopsy and third ventriculostomy. We performed multiple biopsies of both tumors and fenestration of the floor of the third ventricle with a flexible fiberoptic endoscope through a single burr hole. Postoperative quantitative cine-mode magnetic resonance imaging (MRI) confirmed the patency of the fenestration. Selected pineal/posterior third ventricle region tumors, especially radiosensitive germinomas, could be treated with this approach thereby obviating the need for either stereotactic or craniotomy/open biopsy and the subsequent placement of a permanent cerebrospinal fluid (CSF) shunt. The endoscopic approach to tumors in the pineal/posterior third ventricle region provides an accurate straightforward, and safe method of obtaining a diagnosis and treating the associated increased intracranial pressure. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. RP Ellenbogen, RG (reprint author), WALTER REED ARMY MED CTR,DIV NEUROSURG,WASHINGTON,DC 20307, USA. NR 15 TC 35 Z9 35 U1 0 U2 0 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0946-7211 J9 MINIM INVAS NEUROSUR JI Minim. Invasive Neurosurg. PD MAR PY 1997 VL 40 IS 1 BP 13 EP 15 DI 10.1055/s-2008-1053406 PG 3 WC Clinical Neurology; Neuroimaging; Surgery SC Neurosciences & Neurology; Surgery GA WY278 UT WOS:A1997WY27800004 PM 9138302 ER PT J AU Michael, NL Chang, G Louie, LG Mascola, JR Dondero, D Birx, DL Sheppard, HW AF Michael, NL Chang, G Louie, LG Mascola, JR Dondero, D Birx, DL Sheppard, HW TI The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression SO NATURE MEDICINE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; INFECTION AB Delta ellular entry of human immunodeficiency virus type 1 (HIV-1) requires binding to both CD4 (ref. 1, 2) and to one of the chemokine receptors recently discovered to act as coreceptors(3-11). Viruses that infect T-cell lines to form syncytia (syncytium-inducing, SI) are frequently found in late-stage HIV disease and utilize the chemokine receptor CXCR-4; macrophage-tropic viruses are non-syncytium-inducing (NSI), found throughout disease and utilize CCR-5 (ref. 3-11). We postulated that CCR-5 gene defects might reduce infection risk in seronegative subjects and prolong AIDS-free survival in seropositive subjects with NSI but not SI virus. Homozygous (Delta ccr5/Delta ccr5) and heterozygous (CCR5/Delta ccr5) CCR-5 deletions (Delta ccr5)(12,13) were found in 7 (2.7%) and 51 (19.5%), respectively, of 261 seronegative subjects from the San Francisco Men's Health Study. CCR-5/Delta ccr5 genotype was identified in 33 of 172 (19.2%) nonprogressors and 25 of 234 (10.7%) progressors from the seropositive arm of this cohort. The Delta ccr5 allele conferred a significant protective effect against HIV-1 infection (P = 0.001) and a survival advantage against disease progression (P = 0.02). Although both progressing and nonprogressing CCR5/Delta ccr5 subjects were identified, a distinct survival advantage was shown for those with NSI virus (P < 0.0001). Thus, the protective effect of Delta ccr5 against disease progression is lost when the infecting virus uses CXCR-4 as a coreceptor. C1 HENRY M JAKCSON FDN,ROCKVILLE,MD 20850. UNIV CALIF BERKELEY,SCH PUBL HLTH,BERKELEY,CA 94720. USN,MED RES INST,DEPT INFECT DIS,BETHESDA,MD 20889. CALIF DEPT HLTH SERV,BERKELEY,CA 94704. RP Michael, NL (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850, USA. FU NIAID NIH HHS [N01-AI-82515, R01-AI-34783, R01-AI-36661] NR 22 TC 390 Z9 397 U1 1 U2 8 PU NATURE PUBLISHING CO PI NEW YORK PA 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 SN 1078-8956 J9 NAT MED JI Nat. Med. PD MAR PY 1997 VL 3 IS 3 BP 338 EP 340 DI 10.1038/nm0397-338 PG 3 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA WL305 UT WOS:A1997WL30500038 PM 9055864 ER PT J AU Sims, SRF Phillips, MA AF Sims, SRF Phillips, MA TI Target signature consistency of image data fusion alternatives SO OPTICAL ENGINEERING LA English DT Article DE sensor fusion; pyramid processing; image reconstruction ID CONTRAST AB The qualitative and quantitative results of three image data fusion algorithms and their target signature variation are shown. We describe these methods for comparison along with a new and easier to understand process developed for their implementation. We also present an illustration of the effects of variation of the target signature on each of the fusion methods along with measurement of these effects using a new distortion metric. (C) 1997 Society of Photo-Optical Instrumentation Engineers. RP Sims, SRF (reprint author), USA,MISSILE COMMAND,AMSMI,RD,MG,IP,REDSTONE ARSENAL,AL 35898, USA. NR 7 TC 11 Z9 11 U1 0 U2 1 PU SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAR PY 1997 VL 36 IS 3 BP 743 EP 754 DI 10.1117/1.601272 PG 12 WC Optics SC Optics GA WN456 UT WOS:A1997WN45600013 ER PT J AU Verdun, HR Wortman, DE Morrison, CA Bradshaw, JL AF Verdun, HR Wortman, DE Morrison, CA Bradshaw, JL TI Optical properties of Nd3+ in single crystal SrAl12O19 SO OPTICAL MATERIALS LA English DT Article ID LASER MATERIALS; LMA AB The spectroscopic characteristics of triply ionized neodymium in Sr1-xNdxAl12-xMgxO19 for x = 0.03 and 0.15 are presented; one Mg2+ ion per Nd3+ is required for charge compensation. Crystals of this composition are optically uniaxial, with absorption and emission depending strongly on polarization. The room-temperature fluorescence lifetime is 430 mu s for x = 0.03 and 280 mu s for x = 0.15. The main absorption and emission peaks can be fit by assuming the Nd3+ ion substitutes for Sr2+ in a site of D-3h point-group symmetry. A crystal-field Hamiltonian of D-3h symmetry is used to fit the data. A best-fit rms deviation of 4.2 cm(-1) is obtained between 32 experimental and theoretical energy levels for the 13 lowest J-multiplets of the 4f(3) electronic configuration of Nd3+ with the following crystal field parameters: B-20 = -202.8 cm(-1), B-40 = 632.7 cm(-1), B-60 = -1752 cm(-1), and B-66 = -1180 cm(-1). The stimulated emission in the F-4(3/2) --> I-4(9/2), F-4(3/2) --> I-4(11/2), and F-4(3/2) --> I-4(13/2) channels peaks at 902, 1049.7, and 1306.5 nm, respectively, and in all cases it is sigma-polarized. The respective spectroscopically determined stimulated emission cross sections for these wavelengths are 3.7 x 10(-20), 1.1 x 10(-19), and 2.6 x 10(-20) cm(2). The best absorption band for diode-laser pumping is centered at 798 nm, with an absorption coefficient of 14 cm(-1) for x = 0.15 and a full-width at half-maximum of 2.5 nm. C1 USA,RES LAB,ADELPHI,MD 20783. RP Verdun, HR (reprint author), FIBERTEK INC,510 HERNDON PKWY,HERNDON,VA 22070, USA. RI Bradshaw, John/E-8330-2011 NR 27 TC 9 Z9 9 U1 0 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-3467 J9 OPT MATER JI Opt. Mater. PD MAR PY 1997 VL 7 IS 3 BP 117 EP 128 DI 10.1016/S0925-3467(97)00002-5 PG 12 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA WP098 UT WOS:A1997WP09800007 ER PT J AU Leitner, WW Krzych, U AF Leitner, WW Krzych, U TI Plasmodium falciparum malaria blood stage parasites preferentially inhibit macrophages with high phagocytic activity SO PARASITE IMMUNOLOGY LA English DT Article DE Plasmodium falciparum; malaria; macrophage; monocyte; MDM; phagocytosis ID T-CELL RESPONSES; HUMAN MONOCYTES; INVITRO; QUANTITATION; LYMPHOCYTES; INVOLVEMENT; PROTECTION; INFECTION; ANTIGENS; IMMUNITY AB Exposure to malaria blood stage antigens results in several defects of macrophages/monocytes one of which is an irreversible reduction of phagocytic activity. In the present study we analysed phagocytic activity of subpopulations of human monocyte-derived-macrophages (MDM) based on the capacity of individual cells to ingest FITC-labelled microbeads. The results demonstrate that malaria infection affected predominantly MDM subpopulations with high level of phagocytosis. This population decreased during parasitaemia, however, during recovery from the infection the highly phagocytic cells replaced the damaged cells. The exposure of MDM cultures to blood stage antigens showed that the highly active macrophages from persons with active malaria infection decreased further while the population increased during recovery. Furthermore, we observed that while ingestion of a few parasitized RBC (3 schizonts) stimulated phagocytosis, larger amounts or longer exposure periods eventually paralysed the entire phagocytic system. Accordingly, by selectively blocking actively phagocytizing macrophages, the malaria parasite prevents both specific and non-specific immune responses, which are initiated by macrophages as phagocytes and professional antigen presenting cells. RP Leitner, WW (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307, USA. RI Leitner, Wolfgang/F-5741-2011 OI Leitner, Wolfgang/0000-0003-3125-5922 NR 24 TC 11 Z9 11 U1 0 U2 2 PU BLACKWELL SCIENCE LTD PI OXFORD PA P O BOX 88, OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0NE SN 0141-9838 J9 PARASITE IMMUNOL JI Parasite Immunol. PD MAR PY 1997 VL 19 IS 3 BP 103 EP 110 DI 10.1046/j.1365-3024.1997.d01-188.x PG 8 WC Immunology; Parasitology SC Immunology; Parasitology GA WR772 UT WOS:A1997WR77200001 PM 9106816 ER PT J AU Anderson, JE Desmond, GB Lemeshewsky, GP Morgan, DR AF Anderson, JE Desmond, GB Lemeshewsky, GP Morgan, DR TI Reflectance calibrated digital multispectral video: A test-bed for high spectral and spatial resolution remote sensing SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article C1 USA,TOPOG ENGN CTR,WASHINGTON,DC 20310. RP Anderson, JE (reprint author), US GEOL SURVEY,MS 521 NATL CTR,RESTON,VA 22092, USA. NR 12 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD MAR PY 1997 VL 63 IS 3 BP 224 EP & PG 5 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA WL696 UT WOS:A1997WL69600001 ER PT J AU Schow, DA Redmon, B Pryor, JL AF Schow, DA Redmon, B Pryor, JL TI Male menopause - How to define it, how to treat it SO POSTGRADUATE MEDICINE LA English DT Article ID AGING MEN; SPERM PRODUCTION; TESTOSTERONE REPLACEMENT; LUTEINIZING-HORMONE; HYPOGONADAL MEN; SEX STEROIDS; AGE; GONADOTROPIN; ANDROGENS; PLASMA AB Does male menopause exist? If the term implies a physiologic event analogous to female menopause, that is, complete cessation of gonadal reproductive function over a rather limited and relatively well-defined time span that is essentially universal by the sixth decade of life, the answer is no. However, many symptoms often associated with female menopause can occur in middle-aged men, even though the incidence, age at onset, and severity are more variable. With a looser definition, then male menopause does exist and is defined as gradual, age-related decline in gonadal function, which by the fifth or sixth decade of life spans a continuum from frankly hypogonadal to clearly eugonadal and which may have a role in age-related changes in body composition, bone mass, and sexual function. The use of testosterone therapy in eugonadal elderly men to prevent or ameliorate such common conditions of aging as decreased sexual function, diminished bone density, and loss of muscle mass has not been thoroughly researched. Currently, testosterone therapy is indicated for hypogonadism with either decreased libido or mild sexual dysfunction. Routine androgen therapy in aging men should await further evidence of acceptable risk-benefit profiles from clinical trials. C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UNIV MINNESOTA,SCH MED,DEPT MED,DIV ENDOCRINOL DIABET & METAB,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,SCH MED,DEPT UROL SURG,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,SCH MED,DEPT OBSTET & GYNECOL,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,SCH MED,DEPT CELL BIOL & NEUROANAT,MINNEAPOLIS,MN 55455. NR 47 TC 17 Z9 18 U1 0 U2 2 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD MAR PY 1997 VL 101 IS 3 BP 62 EP & PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA WN184 UT WOS:A1997WN18400005 PM 9074551 ER PT J AU Balbuena, L Hayes, D Ramirez, SG Johnson, R AF Balbuena, L Hayes, D Ramirez, SG Johnson, R TI Eagle's syndrome (elongated styloid process) SO SOUTHERN MEDICAL JOURNAL LA English DT Article AB Eagle's syndrome occurs when an elongated styloid process or calcified stylohyoid ligament causes recurrent throat pain or foreign body sensation, dysphagia, or facial pain, Additional symptoms may include neck or throat pain with radiation to the ipsilateral ear, In adults, the styloid process is approximately 2.5 cm long, and its tip is located between the external and internal carotid arteries, just lateral to the tonsillar fossa, It may develop inflammatory changes or impinge on the adjacent arteries or sensory nerve endings, leading to the symptoms described, Diagnosis can usually be made on physical examination by digital palpation of the styloid process in the tonsillar fossa, which exacerbates the pain, In addition, relief of symptoms with injection of an anesthetic solution into the tonsillar fossa is highly suggestive of this diagnosis, Radiographic workup should include anterior-posterior and lateral skull films. The treatment of Eagle's syndrome is primarily surgical, The styloid process can be shortened through an intraoral or external approach, We present two cases and review the literature. C1 BROOKE ARMY MED CTR,OTOLARYNGOL HEAD & NECK SURG SERV,FT SAM HOUSTON,TX 78234. NR 12 TC 39 Z9 45 U1 1 U2 1 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD MAR PY 1997 VL 90 IS 3 BP 331 EP 334 DI 10.1097/00007611-199703000-00014 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA WN241 UT WOS:A1997WN24100013 PM 9076308 ER PT J AU Jones, MP Carrington, L Cutting, M Alving, B AF Jones, MP Carrington, L Cutting, M Alving, B TI Variation in test results for APC resistance with factor V deficient plasma from different donors SO THROMBOSIS AND HAEMOSTASIS LA English DT Letter ID ACTIVATED PROTEIN-C C1 WALTER REED ARMY INST RES,DEPT HEMATOL & VASC BIOL,WASHINGTON,DC 20307. NR 5 TC 2 Z9 2 U1 0 U2 0 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD MAR PY 1997 VL 77 IS 3 BP 601 EP 601 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA WM349 UT WOS:A1997WM34900032 PM 9066017 ER PT J AU Deshpande, SS Sheridan, RE Adler, M AF Deshpande, SS Sheridan, RE Adler, M TI Efficacy of certain quinolines as pharmacological antagonists in botulinum neurotoxin poisoning SO TOXICON LA English DT Article ID TETANUS TOXIN; NEUROTRANSMITTER RELEASE; CLOSTRIDIAL NEUROTOXINS; NEUROMUSCULAR-JUNCTION; CHLOROQUINE; VAMP/SYNAPTOBREVIN; SYNAPTOBREVIN; PROTEOLYSIS; INHIBITION; SNAP-25 AB Various 4- and 8-aminoquinolines, which are effective antimalarial agents, were examined as potential pretreatment compounds for prolongation of the time to 50% block of nerve-elicited muscle twitches in isolated mouse diaphragms exposed to botulinum type A neurotoxin. The 4-aminoquinolines (chloroquine, amodiaquine) and quinacrine, an acridine derivative similar to chloroquine, prolonged the time required for botulinum type A neurotoxin to block neuromuscular transmission by more than 3-fold; 8-aminoquinolines (primaquine and WR242511) had no antibotulinum type A neurotoxin activity. Pyrimethamine, an antimalarial drug lacking the quinoline ring structure, was also ineffective. Rank order potencies based on equimolar effective concentrations for the test compounds were quinacrine > amodiaquine > chloroquine > quinine or quinidine. Maximum protection from botulinum type A neurotoxin-induced neuromuscular block was achieved when muscles were exposed to drug prior to or simultaneously with the toxin. A delay of more than 20 min abolished the protective ability of the antimalarial agents, presumably owing to the release of the toxin from endosomes in quantities sufficient to initiate neuromuscular block. All of the test compounds except quinine and quinidine depressed muscle contractions when concentrations exceeded 20 mu M. In addition, amodiaquine at 50 mu M induced muscle contracture. A combination of agents at low concentrations that act at different steps of botulinum type A neurotoxin poisoning potentiated the prolongation of time to 50% block in an approximately additive fashion. Thus N,N,N',N'-tetrakis(2-pyridyl-methyl)ethylenediamine (2 mu M) and quinacrine (5 mu M), when administered in combination, produced up to a 4-fold increase in time to 50% block. A similar level of protection with quinacrine alone required a 4-fold increase in the aminoquinoline concentration. Although the mechanism of protection by these antimalarial agents is probably through the raising of endosomal pH, the possibility that some of these drugs could also act by inhibiting toxin-induced channel formation cannot be ruled out. (C) 1997 Elsevier Science Ltd. RP Deshpande, SS (reprint author), USA,MED RES INST CHEM DEF,DIV PHARMACOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 28 TC 37 Z9 37 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD MAR PY 1997 VL 35 IS 3 BP 433 EP 445 DI 10.1016/S0041-0101(96)00147-X PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA WM136 UT WOS:A1997WM13600010 PM 9080598 ER PT J AU Chan, MD Dibble, ED Kilgore, KJ AF Chan, MD Dibble, ED Kilgore, KJ TI A laboratory examination of water velocity and substrate preference by age-0 gulf sturgeons SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID HABITAT USE; SELECTION; RIVER AB We examined microhabitat selection by the Gulf sturgeon Acipenser oxyrinchus desotoi a subspecies of Atlantic sturgeon that is listed as threatened by the U.S, government. Individuals and;groups of sturgeons were placed in a Ferguson flume at low (4-6 cm/s) and high (5-17 cm/s) water flows, and their distributions relative to substrate and water velocity were recorded with a video camera. A Jacobs' selectivity index (D) was used to evaluate substrate and velocity preference by the fish. Distribution of individual fish, relative to water velocity, differed significantly in the low (chi(2) = 11.8, df = 2, P < 0.05) and high (chi(2) = 39.0, df = 12, P < 0.05) water flows. Groups also selected velocities within low (chi(2) = 36.1, df = 2, P < 0.05) and high (chi(2) = 63.8, df = 12, P < 0.05) flows. Individual fish did not select substrates in low flow but moderately preferred cobble (D = 0.32) in high flow. Groups moderately preferred sand (D = 0.40) and moderately avoided cobble (D = -0.47) in low flow. No selection was observed by groups in high flow. Differences in use of substrate types by individual fish were not significant in low flow (chi(2) = 4.43, df = 2, P greater than or equal to 0.05); however, the differences were significant in the other treatment combinations (group, low flow: chi(2) = 134.2, df = 2, P < 0.05; group, high flow: chi(2) = 21.05, df = 2, P < 0.05; individual, high flow: chi(2) = 11.03, df = 2, P < 0.05). Results from this laboratory experiment have implications for future microhabitat studies and represent the first quantified look at microhabitat selection by age-0 Gulf sturgeons. C1 USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. NR 13 TC 18 Z9 21 U1 0 U2 8 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 SN 0002-8487 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PD MAR PY 1997 VL 126 IS 2 BP 330 EP 333 DI 10.1577/1548-8659(1997)126<0330:ALEOWV>2.3.CO;2 PG 4 WC Fisheries SC Fisheries GA WW217 UT WOS:A1997WW21700015 ER PT J AU Hirumi, H Martin, S Hirumi, K Inoue, N Kanbara, H Saito, A Suzuki, N AF Hirumi, H Martin, S Hirumi, K Inoue, N Kanbara, H Saito, A Suzuki, N TI Cultivation of bloodstream forms of Trypanosoma brucei and T-evansi in a serum-free medium SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE T-brucei; T-evansi; cultivation; serum-free medium ID BLOOD-STREAM FORMS; FEEDER CELL-LAYERS; FETAL BOVINE SERUM; AFRICAN TRYPANOSOMES; GROWTH REQUIREMENTS; INVITRO; GAMBIENSE; CULTURES; STOCKS AB Bloodstream forms of Trypanosoma brucei and T. evansi have been cultivated in an axenic culture system by using Iscove's modified DMEM-based HMI-9 medium supplemented with bathocuproinedisulphonic acid, L-cysteine, hypoxanthine, 2-mercaptoethanol, pyruvate, thymidine and 10% fetal bovine or adult horse serum. We developed a serum-free medium (HMI-244) in which serum in HMI-g was replaced by fatty acid-free bovine serum albumin, bovine alpha(2)-macroglobulin, bovine beta-lipoprotein, d-biotin, retinol, beta-alanine, L-anserine nitrate salt, L-ornithine hydrochloride, O-phosphorylethanolamine, sarcosine, taurine, adenosine- 5'-triphosphate, 2'-deoxycytidine-5'-monophosphate, 2'-deoxyguanosine-5'-monophosphate, and 5-methyltetrahydrofolic acid. Maximum cell densities and population doubling times were 2.6 X 10(6) cells/ml; 10.6 hours and 2.2 x 10(6) cells/ml; 10.9 hours for T. brucei and T. evansi, respectively. Bloodstream forms continued to proliferate in the serum-free cultures for more than go days and the trypomastigotes retained their morphological characteristics and infectivity to mice. If validated, this serum-free medium may help reduce future interlaboratory variability in biochemical, immunological, molecular biological and drug sensitivity studies on these parasites. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NAGASAKI UNIV,DEPT PROTOZOL,INST TROP MED,NAGASAKI 852,JAPAN. OBIHIRO UNIV AGR & VET MED,DEPT VET PHYSIOL,OBIHIRO,HOKKAIDO 080,JAPAN. RP Hirumi, H (reprint author), OBIHIRO UNIV AGR & VET MED,RES CTR PROTOZOAN MOL IMMUNOL,OBIHIRO,HOKKAIDO 080,JAPAN. NR 22 TC 10 Z9 10 U1 0 U2 7 PU BLACKWELL SCIENCE LTD PI OXFORD PA P O BOX 88, OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0NE SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD MAR PY 1997 VL 2 IS 3 BP 240 EP 244 DI 10.1046/j.1365-3156.1997.d01-268.x PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA WN955 UT WOS:A1997WN95500006 PM 9491102 ER PT J AU McLeod, DG Johnson, CF Klein, E Peabody, JO Coffield, S Soloway, M AF McLeod, DG Johnson, CF Klein, E Peabody, JO Coffield, S Soloway, M TI PSA levels and the rate of positive surgical margins in radical prostatectomy specimens preceded by androgen blockade in clinical B-2 (T2bNxMo) prostate cancer SO UROLOGY LA English DT Article; Proceedings Paper CT First International Conference on Neoadjuvant Hormonal Therapy of Prostate Cancer CY MAR 29-30, 1996 CL BOSTON, MA SP Amer Inst Med Law ID DEPRIVATION; ANTIGEN AB Objectives. Neoadjuvant hormonal therapy reduces positive margins in patients undergoing radical prostatectomy. All patients experience a decrease in serum prostate specific antigen (PSA), but not always to a level that is nondetectable. The results of several prospective, randomized trials indicate that the incidence of positive margins decreases with the use of androgen deprivation prior to radical prostatectomy. It has been suggested that a greater decline in PSA levels would result in fewer positive margins. In a recent US trial of patients with T2bNxMO prostate cancer, we reported that 18% of patients randomized to receive 3 months of leuprolide acetate and flutamide had positive margins, compared to 48% of those who had radical prostatectomy alone (P < 0.001). We correlated the PSA levels prior to and following androgen deprivation and the presence of a positive margin following radical prostatectomy (RP). Methods. One hundred and thirty-seven of 149 patients randomized to receive presurgery androgen deprivation (AD) underwent radical prostatectomy. Of these, 135 had a PSA level obtained both prior to androgen deprivation and prior to surgery. We analyzed the percent positive margins in patients whose PSA values became undetectable and in those whose values remained above 0.1 ng/mL despite androgen deprivation. Results. Eight of 45 patients (19%) with a nadir PSA less than or equal to 0.1 ng/mL had a positive surgical margin and 16/92 (17%) with a nadir PSA > 0.1 ng/mL had tumor at the margin. There were no statistical differences in these two groups (P = 1.0 by Fisher's Exact Test [two-tailed], and the Pearson correlation was -0.015). Conclusions. There was no correlation between an undetectable PSA and a PSA > 0.1 ng/mL and the presence of tumor at the margin when 3 months of AD was given prior to RP. It is possible that longer periods of AD prior to RP will reduce PSA to an undetectable level in a higher percent of patients. However, these data suggest that an undetectable level will not result in less positive margins. (C) 1997 by Elsevier Science Inc. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. TEXAS A&M UNIV,OLIN E TEAGUE VET CTR,TEMPLE,TX 76504. CLEVELAND CLIN,CLEVELAND,OH 44106. HENRY FORD HOSP,DETROIT,MI 48202. UNIV MIAMI,SCH MED,MIAMI,FL. RP McLeod, DG (reprint author), WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307, USA. NR 10 TC 11 Z9 11 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD MAR PY 1997 VL 49 IS 3A SU S BP 70 EP 73 DI 10.1016/S0090-4295(97)00172-6 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA WQ712 UT WOS:A1997WQ71200011 PM 9123740 ER PT J AU Hart, MK Pratt, W Panelo, F Tammariello, R Dertzbaugh, M AF Hart, MK Pratt, W Panelo, F Tammariello, R Dertzbaugh, M TI Venezuelan equine encephalitis virus vaccines induce mucosal IgA responses and protection from airborne infection in BALB/c, but not C3H/HeN mice SO VACCINE LA English DT Article DE Venezuelan equine encephalitis virus; mucosal immunity; aerosol exposure ID MONOCLONAL-ANTIBODIES; CHOLERA-TOXIN; CHALLENGE; HAMSTERS; IMMUNITY AB Immunization with either a live-attenuated (TC-83) or formalin-inactivated (C-84) vaccine for Venezuelan equine encephalitis (VEE) virus protected BALB/c mice from lethal VEE infection acquired subcutaneously or by aerosol. While vaccinated C3H/HeN mice were also protected from parenteral infection, neither vaccine protected these mice from an aerosol infection. The apparent vaccine failures in C3H/HeN mice could not be attributed to deficiencies in virus-neutralizing antibodies in serum, as these responses were typically of equal or higher titer than those observed in protected BALB/c mice before challenge. IgG subclass analysis offered no facile explanation: profiles of IgG2a dominance were observed in C3H/HeN mice given either vaccine and in BALB/c mice given the live-attenuated vaccine, whereas BALB/c antibody responses shifted toward IgG1 dominance after immunization with the killed C-84 vaccine. Data from immunized congenic mice showed that the H-2 genes from the C3H/He mice were not singularly responsible for the inability of these mice to resist aerosol infection with VEE virus. VEE virus-specific IgA responses were detected more frequently in respiratory and vaginal secretions obtained from the protected BALB/c mice. Published by Elsevier Science Ltd. C1 USA,MED RES INST INFECT DIS,DIV TOXINOL,FT DETRICK,FREDERICK,MD 21702. RP Hart, MK (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,FREDERICK,MD 21702, USA. NR 25 TC 41 Z9 42 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD MAR PY 1997 VL 15 IS 4 BP 363 EP 369 DI 10.1016/S0264-410X(96)00204-6 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA WT721 UT WOS:A1997WT72100006 PM 9141206 ER PT J AU McFaul, S Salvatore, J Harbor, L Hill, H Villa, V AF McFaul, S Salvatore, J Harbor, L Hill, H Villa, V TI Binding of hemoglobin to leukocytes. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,BLOOD RES DETACHMENT,WASHINGTON,DC 20503. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 184 EP 184 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53000184 ER PT J AU Allison, WF Blanchard, LA Gonzalez, RR Rudolph, K Kluger, MJ AF Allison, WF Blanchard, LA Gonzalez, RR Rudolph, K Kluger, MJ TI Are cytokines mediating an elevated core temperature in the luteal phase of the female menstrual cycle? SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. LOVELACE BIOMED & ENVIRONM RES INST,ALBUQUERQUE,NM 87108. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 511 EP 511 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53000511 ER PT J AU Kolka, MA Levine, L Stephenson, LA AF Kolka, MA Levine, L Stephenson, LA TI Feasibility of core temperature measurement via telemetry under protective clothing. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST ENVIRONM MED,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 521 EP 521 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53000519 ER PT J AU Matylevitch, NP Mata, JR Schuschereba, ST Lawlor, DF Bowman, PD Goodwin, CW AF Matylevitch, NP Mata, JR Schuschereba, ST Lawlor, DF Bowman, PD Goodwin, CW TI Apoptosis and necrosis in cultured human keratinocytes after thermal injury SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. USA,MED DETACHMENT,SAN ANTONIO,TX 78235. USA,MED DETACHMENT,SAN ANTONIO,TX 78235. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 664 EP 664 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53000664 ER PT J AU Gilligan, GR Mata, JR Delgado, A Burleson, D Cassidy, R Bowman, PD Goodwin, CW AF Gilligan, GR Mata, JR Delgado, A Burleson, D Cassidy, R Bowman, PD Goodwin, CW TI Induction of cytokine synthesis in human whole blood by lipopolysaccharide assessed by reverse transcriptase polymerase chain reaction (RT-PCR). SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 679 EP 679 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53000680 ER PT J AU Gretz, JE Anderson, AO Shaw, S AF Gretz, JE Anderson, AO Shaw, S TI Lymph node reticulum - Conduit facilitating immune surveillance SO FASEB JOURNAL LA English DT Meeting Abstract C1 NCI,NIH,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,DEPT RESP & MUCOSAL IMMUNOL,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 687 EP 687 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53000687 ER PT J AU Bowman, PD Gilligan, GR Mata, JR Matylevich, NP Lawlor, DF Goodwin, CW AF Bowman, PD Gilligan, GR Mata, JR Matylevich, NP Lawlor, DF Goodwin, CW TI Induction of cytokine and heat shock protein 70 RNA in normal human keratinocytes by thermal injury assessed by reverse transcriptase-polymerase chain reaction SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 706 EP 706 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53000708 ER PT J AU Anderson, DR Byers, SL AF Anderson, DR Byers, SL TI Effects of sulfur mustard inhalation on pulmonary function parameters. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,APPL PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 720 EP 720 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53000718 ER PT J AU Bathalon, GP Vinken, AG Tucker, KL Roberts, SB AF Bathalon, GP Vinken, AG Tucker, KL Roberts, SB TI The accuracy of dietary reporting in postmenopausal women classified as restrained or unrestrained eaters. SO FASEB JOURNAL LA English DT Meeting Abstract C1 TUFTS UNIV,USDA,HUMAN NUTR RES CTR AGING,BOSTON,MA 02111. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RI Tucker, Katherine/A-4545-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 941 EP 941 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53000941 ER PT J AU Cline, AD Warber, JP Champagne, CM AF Cline, AD Warber, JP Champagne, CM TI Assessment of meal consumption behaviors by physically active young men dining in a cafeteria setting. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. PENNINGTON BIOMED RES CTR,BATON ROUGE,LA 70808. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 1070 EP 1070 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53001068 ER PT J AU BakerFulco, CJ Strowman, S Pusateri, A Cline, A Marchitelli, L AF BakerFulco, CJ Strowman, S Pusateri, A Cline, A Marchitelli, L TI Body weight satisfaction and weight loss attempts in army women. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 1071 EP 1071 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53001071 ER PT J AU Deshpande, S Filbert, M AF Deshpande, S Filbert, M TI Anticholinergic drug procyclidine blocks glutamate and cyanide-induced neurotoxicity in rat cultured cortical neurones. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,DIV PHARMACOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 1211 EP 1211 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53001211 ER PT J AU Ray, P Millard, CB Petrali, JP Berman, JD Ray, R AF Ray, P Millard, CB Petrali, JP Berman, JD Ray, R TI Arachidonic acid mediated neuroexocytosis in PC12 cells in the absence of SNAP25. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 1227 EP 1227 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53001227 ER PT J AU Atkins, J Lee, W Scott, Z Johnson, K Pearce, F AF Atkins, J Lee, W Scott, Z Johnson, K Pearce, F TI Oxygen inhalation after hemorrhage increases mean arterial blood pressure (MABP) and carotid blood flow. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 1662 EP 1662 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53001663 ER PT J AU Sondeen, JL Coppes, VG Dubick, MA AF Sondeen, JL Coppes, VG Dubick, MA TI Biphasic response of white blood cell count following combined hemorrhage-bilateral renal ischemia/reperfusion injury in rabbits. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,SAN ANTONIO,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 1664 EP 1664 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53001664 ER PT J AU Dubick, MA Sondeen, JL Coppes, VG AF Dubick, MA Sondeen, JL Coppes, VG TI Antioxidant status in tissue from rabbits following hemorrhage and renal ischemia/reperfusion (I/R) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,SAN ANTONIO,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 1665 EP 1665 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53001665 ER PT J AU Shitzer, A Bellomo, S Stroschein, LA Gonzalez, RR Pandolf, KB AF Shitzer, A Bellomo, S Stroschein, LA Gonzalez, RR Pandolf, KB TI Simulation of a cold-stressed finger including the effects of wind, gloves and cold-induced vasodilation. SO FASEB JOURNAL LA English DT Meeting Abstract C1 TECHNION ISRAEL INST TECHNOL,DEPT MECH ENGN,IL-32000 HAIFA,ISRAEL. USA,INST ENVIRONM MED,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 1679 EP 1679 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53001678 ER PT J AU Durkot, MJ Hoyt, TW Fulco, CS Tharion, WJ Cymerman, A AF Durkot, MJ Hoyt, TW Fulco, CS Tharion, WJ Cymerman, A TI Improved physical performance with acclimatization to altitude is associated with increased fractional fat oxidation. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 1700 EP 1700 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53001700 ER PT J AU Yang, DCH Yan, Z Jett, M AF Yang, DCH Yan, Z Jett, M TI Protein kinase C is involved in staphylococcal enterotoxin B (SEB)-induced TNF-alpha production SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. GEORGETOWN UNIV,DEPT CHEM,WASHINGTON,DC 20056. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 1922 EP 1922 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53001920 ER PT J AU Kausalya, S Nath, J AF Kausalya, S Nath, J TI Interactive role of nitric oxide and reactive oxygen species in neutrophil endothelial cell interaction. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 1953 EP 1953 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53001953 ER PT J AU Chakrabarti, A Ray, P AF Chakrabarti, A Ray, P TI Isolation, purification and characterization of protease activated in sulfur mustard and nitrogen mustard treated human keratinocytes. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 2123 EP 2123 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53002123 ER PT J AU Tharion, WJ Hoyt, RW DeLany, JP Cline, AD Lieberman, HR AF Tharion, WJ Hoyt, RW DeLany, JP Cline, AD Lieberman, HR TI Effect of a carbohydrate drink on energy and fluid balance during a military field exercise in the desert. SO FASEB JOURNAL LA English DT Meeting Abstract C1 GEOCENTERS INC,USA,ENVIRONM MED RES INST,NATICK,MA 01760. PENNINGTON BIOMED RES CTR,BATON ROUGE,LA 70808. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 2558 EP 2558 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53002559 ER PT J AU Hoyt, RW Opstad, PK Haugen, AH DeLany, JP Cymerman, A Redmond, DP Friedl, KE AF Hoyt, RW Opstad, PK Haugen, AH DeLany, JP Cymerman, A Redmond, DP Friedl, KE TI Energy balance in soldiers over 7 days of sustained exercise with severe caloric and sleep deficits. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST ENVIRONM MED,NATICK,MA 01760. PENNINGTON BIOMED RES CTR,BATON ROUGE,LA 70808. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 2559 EP 2559 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53002557 ER PT J AU Claybaugh, JR Sato, AK Hassell, LH AF Claybaugh, JR Sato, AK Hassell, LH TI The effect of gender and menstrual cycle phase on the diurnal response to a water load SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 2670 EP 2670 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53002668 ER PT J AU Uyehara, CFT Hashiro, GM Lee, WQ Whippo, PE Claybaugh, JR AF Uyehara, CFT Hashiro, GM Lee, WQ Whippo, PE Claybaugh, JR TI Vasopressin improves blood gases in hypoxia-induced pulmonary hypertension via regional blood flow redistribution. SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 2674 EP 2674 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53002673 ER PT J AU Urada, KK Claybaugh, JR Sato, AK AF Urada, KK Claybaugh, JR Sato, AK TI Splenectomy alters the normal response to hemorrhage in the goat. SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. UNIV HAWAII MANOA,DEPT PHYSIOL,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 2675 EP 2675 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53002676 ER PT J AU Wang, T Zhang, C Kiang, JG Hicks, GL AF Wang, T Zhang, C Kiang, JG Hicks, GL TI Gene expression of heat shock protein 70 kD during cardiac preservation. SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV ROCHESTER,DEPT SURG,ROCHESTER,NY 14642. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 2962 EP 2962 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53002962 ER PT J AU Pandolf, KB Lee, DT Young, AJ Sawka, MN AF Pandolf, KB Lee, DT Young, AJ Sawka, MN TI Human cold acclimation after repeated 20 degrees C water immersion. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 3044 EP 3044 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53003045 ER PT J AU Matthew, CB DuBose, DA Tartarini, K Sils, I AF Matthew, CB DuBose, DA Tartarini, K Sils, I TI In vivo quantitation of hyperthermia-induced changes in vascular permeability. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 3049 EP 3049 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53003048 ER PT J AU Yan, Z Neil, R Yang, DCH Jett, M AF Yan, Z Neil, R Yang, DCH Jett, M TI Expression and purification of truncates SEB proteins for vaccine research SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. GEORGETOWN UNIV,DEPT CHEM,WASHINGTON,DC 20056. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 3082 EP 3082 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53003084 ER PT J AU Ray, R Benton, BJ Gross, CL AF Ray, R Benton, BJ Gross, CL TI Cellular effects of glutathione (GSH) depletion. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 3167 EP 3167 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53003167 ER PT J AU Werrlein, R MadrenWhalley, J AF Werrlein, R MadrenWhalley, J TI Calcium: A potential factor in sulfur mustard toxicity. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 3169 EP 3169 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53003171 ER PT J AU Jerome, EH Poli, M Staub, NC AF Jerome, EH Poli, M Staub, NC TI Instilled ricin alters lung liquid and protein balance in awake sheep. SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV CALIF SAN FRANCISCO,DEPT ANESTHESIA,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,INST CARDIOVASC RES,SAN FRANCISCO,CA 94143. USA,MED RES INST,FT DETRICK,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 3238 EP 3238 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53003240 ER PT J AU Marchitelli, LJ Friedl, KE Patton, JF Mello, RP Karge, WH AF Marchitelli, LJ Friedl, KE Patton, JF Mello, RP Karge, WH TI Validity of the US Army male body fat equation in senior career soldiers. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. USA,MED RES NAT CMD,FT DETRICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 3415 EP 3415 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53003417 ER PT J AU Burleson, DG Cioffi, WA Pruitt, BA AF Burleson, DG Cioffi, WA Pruitt, BA TI Changes in lymphocyte activation with omega-3 fatty acid supplementation in burned patients SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 3550 EP 3550 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53003552 ER PT J AU ShukittHale, B Tharion, WJ Lieberman, HR AF ShukittHale, B Tharion, WJ Lieberman, HR TI Effects of sleep deprivation and environmental stress on mental performance and marksmanship. SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,GEOCENTERS INC,DIV MIL NUTR,NATICK,MA 01760. TUFTS UNIV,USDA,HUMAN NUTR RES CTR AGING,BOSTON,MA 02111. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 3666 EP 3666 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53003666 ER PT J AU Nath, J Kausalya, S AF Nath, J Kausalya, S TI Inverse correlation between superoxide and nitric oxide generation in activated human neutrophils: Studies in unprimed and endotoxin-primed cells. SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 28 PY 1997 VL 11 IS 3 BP 3714 EP 3714 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA WL530 UT WOS:A1997WL53003716 ER PT J AU Baskin, SI Thomsen, RH Maxwell, DM AF Baskin, SI Thomsen, RH Maxwell, DM TI The effects of AF-DX 116, a cardioselective muscarinic antagonist, on the negative inotropic action of soman, a cholinesterase inhibitor SO LIFE SCIENCES LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PD FEB 21 PY 1997 VL 60 IS 13-14 BP 57 EP 57 PG 1 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA WM778 UT WOS:A1997WM77800083 ER PT J AU Huang, Q Ashley, PR AF Huang, Q Ashley, PR TI Holographic Bragg grating input-output couplers for polymer waveguides at an 850-nm wavelength SO APPLIED OPTICS LA English DT Article DE grating coupler; waveguide coupler; holographic Bragg grating ID INTERCONNECTS AB Bragg gratings used as input-output couplers in polymeric waveguides have been demonstrated at infrared wavelengths. These Bragg grating couplers were holographically formed volume phase gratings with a near-45 degrees fringe slant angle embedded directly into a waveguide layer. A photopolymer was used for both producing a planar waveguide and constructing the embedded Bragg grating coupler. A. coupling efficiency of 23% for input and 5% for output has been achieved at 850 nm. The output-coupling beam profiles are also discussed. (C) 1997 Optical Society of America. C1 USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAPONS SCI DIRECTORATE,AMSMI,RD,WS,CM,REDSTONE ARSENAL,AL 35898. NR 15 TC 30 Z9 30 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD FEB 20 PY 1997 VL 36 IS 6 BP 1198 EP 1203 DI 10.1364/AO.36.001198 PG 6 WC Optics SC Optics GA WH289 UT WOS:A1997WH28900016 PM 18250791 ER PT J AU Szafranski, P Mello, CM Sano, T Smith, CL Kaplan, DL Cantor, CR AF Szafranski, P Mello, CM Sano, T Smith, CL Kaplan, DL Cantor, CR TI A new approach for containment of microorganisms: Dual control of streptavidin expression by antisense RNA and the T7 transcription system SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE heterologous gene expression; bioremediation; Pseudomonas putida ID CONDITIONAL SUICIDE SYSTEM; BROAD-HOST-RANGE; PSEUDOMONAS-PUTIDA; ESCHERICHIA-COLI; BIOLOGICAL CONTAINMENT; GENE; BACTERIA; CLONING; POLYMERASE; PLASMIDS AB The use of microorganisms in the open environment would be of less concern if they were endowed with programmed self-destruction mechanisms, Here, we propose a new genetic design to increase the effectiveness of cell suicide systems. It ensures very tight control of the derepression of cell death by the combination of the bacteriophage T7 RNA polymerase-lysozyme system and an inducible synthesis of antisense RNA and the Escherichia coli LacI repressor, Functionality of this regulatory concept was tested by applying it to containment of Gram-negative bacteria, based on the conditional expression of the lethal Streptomyces avidinii streptavidin gene, Toxicity of streptavidin is derived from its exceptionally high binding affinity for an essential prosthetic group, D-biotin, The entire construct was designed to allow the soil bacterium Pseudomonas putida to survive only in the presence of aromatic hydrocarbons and their derivatives which it can degrade, Under favorable growth conditions, clones escaping killing appeared at frequencies of only 10(-7)-10(-8) per cell per generation, The general requirement for biotin through the living world should make streptavidin-based conditional lethal designs applicable to a broad range of containment strategies. C1 BOSTON UNIV,DEPT BIOMED ENGN,BOSTON,MA 02215. BOSTON UNIV,DEPT BIOL,BOSTON,MA 02215. BOSTON UNIV,DEPT PHARMACOL & EXPT THERAPEUT,BOSTON,MA 02215. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RP Szafranski, P (reprint author), BOSTON UNIV,CTR ADV BIOTECHNOL,BOSTON,MA 02215, USA. OI Smith, Cassandra/0000-0002-0346-8907 NR 27 TC 25 Z9 28 U1 1 U2 5 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD FEB 18 PY 1997 VL 94 IS 4 BP 1059 EP 1063 DI 10.1073/pnas.94.4.1059 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA WJ621 UT WOS:A1997WJ62100003 PM 9037005 ER PT J AU Tidrow, MZ Chiang, JC Li, SS Bacher, K AF Tidrow, MZ Chiang, JC Li, SS Bacher, K TI A high strain two-stack two-color quantum well infrared photodetector SO APPLIED PHYSICS LETTERS LA English DT Article ID INTERSUBBAND TRANSITIONS; GAAS/ALGAAS AB A high strain two-stack, two-color, InGaAs/AlGaAs and AlGaAs/GaAs quantum well infrared photodetector for midwavelength infrared (MWIR) and long wavelength infrared (LWIR) detection has been demonstrated. Each stack is designed to have detection in one of the two atmospheric windows, 3-5 mu m and 8-12 mu m, respectively. The MWIR stack has employed 35% of indium in the InGaAs well, which not only achieved peak wavelength at 4.3 mu m, but also obtained very high peak responsivity of R(p) = 0.65 A/W, using 45 degrees light coupling. Normal incidence without grating coupling also has high responsivity with 40%-50% in the MWIR stack and 35%-45% in the LWIR stack, respectively, compared with the 45 degrees incidence, Despite the large in-plane compressive strain induced by the high indium concentration, the device is highly uniform and has very low dark current in the MWIR stack. The background limited temperature is 125 K for the MWIR stack with a cutoff wavelength lambda(c) = 4.6 mu m, and is 70 K for the LWIR stack with lambda(c) = 10 mu m. (C) 1997 American Institute of Physics. C1 UNIV FLORIDA,DEPT ELECT & COMP ENGN,GAINESVILLE,FL 32611. QUANTUM EPITAXIAL DESIGNS INC,BETHLEHEM,PA 18015. RP Tidrow, MZ (reprint author), USA,RES LAB,EI,SE,AMSRL,FT MONMOUTH,NJ 07703, USA. NR 8 TC 64 Z9 65 U1 0 U2 7 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD FEB 17 PY 1997 VL 70 IS 7 BP 859 EP 861 DI 10.1063/1.118298 PG 3 WC Physics, Applied SC Physics GA WH866 UT WOS:A1997WH86600023 ER PT J AU Stamatos, NM Gomatos, PJ Cox, J Fowler, A Dow, N Wohlhieter, JA Cross, AS AF Stamatos, NM Gomatos, PJ Cox, J Fowler, A Dow, N Wohlhieter, JA Cross, AS TI Desialylation of peripheral blood mononuclear cells promotes growth of HIV-1 SO VIROLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; LYMPHOCYTES-T; SIALIC-ACID; INFECTION INVITRO; DENDRITIC CELLS; CD4 RECEPTOR; REPLICATION; ACTIVATION; SIALYLATION; PROTEIN AB Activation of peripheral blood CD4(+) helper T lymphocytes establishes a permissive state for growth of HIV-1. Activated T lymphocytes expressed increased sialidase (neuraminidase) activity and were hyposialylated. Treatment of freshly isolated peripheral blood mononuclear cells (PBMCs) with microbial neuraminidase (NANase) or phytohemagglutinin (PHA) prior to infection at low multiplicity with T cell line-adapted HIV-1(IIB) resulted in production of large amounts of p24 antigen and reverse transcriptase. In contrast, neither viral component was detected in the medium of mock-treated cells infected at a similar multiplicity through 21 days in culture. The titer of a stock solution of HIV-1(IIB) was 1.4+/-0.18 log(10) greater in NANase-treated PBMCs than in mock-treated cells; the titer was similarly raised 1.5 to 1.76+/-0.18 log(10) in PHA-treated cells. Growth of the primary isolate HIV-1(91/US/056) was also enhanced in NANase-treated PBMCs; the titer of a stock solution of HIV-1(91/US/056) was 1.0+/-0.16 log(10) greater in NANase-treated PBMCs than in mock-treated cells 7 days after infection. No enhancement of viral growth in PBMCs was detected when NANase was heat-inactivated or specifically inhibited with 2,3-dehydro-2-desoxy-N-acetyl-neuraminic acid prior to use. Treatment of PBMCs with NANase did not alter the distribution of lymphocyte subsets nor change the density of CD4 antigen per cell after 7 days in culture. Whereas PHA treatment of PBMCs was mitogenic, pretreatment with NANase was not; the amount of [H-3]thymidine incorporated into DNA and culture growth characteristics were similar for NANase- and mock-treated cells. Thus, desialylation of PBMCs promoted a permissive state for growth of HIV-1 without affecting the rate of DNA synthesis or relative number of target CD4(+) cells. (C) 1997 Academic Press. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. SRA TECHNOL INC,ROCKVILLE,MD 20850. RP Stamatos, NM (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307, USA. OI Cox, Josephine/0000-0003-1301-7373 NR 39 TC 22 Z9 23 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD FEB 17 PY 1997 VL 228 IS 2 BP 123 EP 131 DI 10.1006/viro.1996.8373 PG 9 WC Virology SC Virology GA WK177 UT WOS:A1997WK17700001 PM 9123818 ER PT J AU Charles, PC Brown, KW Davis, NL Hart, MK Johnston, RE AF Charles, PC Brown, KW Davis, NL Hart, MK Johnston, RE TI Mucosal immunity induced by parenteral immunization with a live attenuated Venezuelan equine encephalitis virus vaccine candidate SO VIROLOGY LA English DT Article ID RECOMBINANT VACCINIA; ORAL IMMUNIZATION; PROTECTS MICE; CELL-CULTURE; CDNA CLONE; CHALLENGE; MUTANTS; PENETRATION; MUTATIONS; INFLUENZA AB Induction of a mucosal immune response is generally thought to require introduction of an immunogen directly onto the mucosal surface. It has been observed, however, that live, attenuated mutants of the alphavirus, Venezuelan equine encephalitis virus (VEE), induce protection from virulent challenge at the respiratory mucosa even after parenteral inoculation. In this report, we propose a mechanism by which subcutaneous immunization with a molecularly cloned, attenuated double mutant of VEE is able to stimulate the production of mucosal anti-VEE IgA. Our results showed that the immunizing virus spread to, and replicated within, lymphoid tissues throughout the mouse. Several tissues known to be inductive sites of the mucosal immune system were found to be positive for the presence of VEE RNA by 48 hr postimmunization. Moreover, this mucosal lymphotropism resulted in the production of virus-specific IgA antibody detectable in vaginal secretions of immunized mice. (C) 1997 Academic Press. C1 UNIV N CAROLINA,SCH MED,DEPT MICROBIOL & IMMUNOL,CHAPEL HILL,NC 27599. USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. FU NIAID NIH HHS [T32-AI07419]; NINDS NIH HHS [NS26681] NR 25 TC 47 Z9 47 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD FEB 17 PY 1997 VL 228 IS 2 BP 153 EP 160 DI 10.1006/viro.1996.8381 PG 8 WC Virology SC Virology GA WK177 UT WOS:A1997WK17700004 PM 9123821 ER PT J AU Grabenstein, JD AF Grabenstein, JD TI Status and future of vaccines for adults SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Article DE age; BCG vaccines; cholera vaccines; diphtheria and tetanus toxoids; hepatitis A vaccines; herpes vaccines; immunization; Lyme disease vaccines; malaria vaccines; neoplasm vaccines; pertussis vaccines; pneumococcal vaccines; product development; rabies vaccines; research; typhoid vaccines; vaccines; varicella vaccines ID INFLUENZA VACCINE; HEPATITIS-A; ELDERLY PERSONS; COST-EFFECTIVENESS; CONTROLLED TRIAL; UNITED-STATES; EFFICACY; HEALTHY; TUBERCULOSIS; METAANALYSIS AB The current status and future prospects of vaccines for adults are discussed. For every child in America who dies of a vaccine-preventable disease, about 400 adults die of such a disease. Evidence of the merit of influenza vaccination continues to accumulate, yet <30% of high-risk people younger than 65 have been vaccinated. Use of pneumococcal vaccine lags behind that of influenza vaccine. Serious discrepancies in immunization levels exist among different segments of U.S. adult society. A vaccination status assessment is now recommended for everyone reaching the age of 50. New vaccines are available to prevent varicella, hepatitis A, and typhoid fever. There are now two formulations of hepatitis A virus vaccine; adult users of these vaccines include travelers, people relocating to areas with poor sanitation, military personnel, laboratory workers, and hemophiliacs. New rabies vaccines may be the next vaccines to be used primarily in adults. Vaccines against pertussis, Lyme disease, cholera, herpes simplex, malaria, other infectious diseases, and cancer are in various stages of development. For health care personnel in areas where there is a strong likelihood of Mycobacterium tuberculosis transmission and infection, BCG vaccination is recommended. The risk of immunization to a person infected with the human immunodeficiency virus is likely out-weighed by the protection offered against other health threats. Health systems should select tetanus-diphtheria toxoids adsorbed for their formularies for immunizing adults, not monovalent tetanus toxoid. Vaccines are available to prevent a growing list of infectious diseases but are underused in adults. C1 UNIV N CAROLINA,SCH PUBL HLTH,CHAPEL HILL,NC 27599. RP Grabenstein, JD (reprint author), UNIV N CAROLINA,SCH PHARM,USA,DEPT MED,BOX 7360,CHAPEL HILL,NC 27599, USA. NR 93 TC 4 Z9 4 U1 1 U2 6 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD FEB 15 PY 1997 VL 54 IS 4 BP 379 EP 387 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA WJ803 UT WOS:A1997WJ80300008 PM 9043559 ER PT J AU Perfetto, SP Hickey, TE Blair, PJ Maino, VC Wagner, KF Zhou, S Mayers, DL StLouis, D June, CH Siegel, JN AF Perfetto, SP Hickey, TE Blair, PJ Maino, VC Wagner, KF Zhou, S Mayers, DL StLouis, D June, CH Siegel, JN TI Measurement of CD69 induction in the assessment of immune function in asymptomatic HIV-infected individuals SO CYTOMETRY LA English DT Article DE flow cytometry; CD69; HIV-1; T cell activation; T cell receptor ID HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL ACTIVATION; PROTEIN-TYROSINE PHOSPHORYLATION; ENVELOPE GLYCOPROTEIN; SIGNAL-TRANSDUCTION; TYPE-1 INFECTION; PROGRAMMED DEATH; SELECTIVE LOSS; MESSENGER-RNA; LYMPHOCYTES-T AB Peripheral blood mononuclear cells from many asymptomatic HIV-infected patients exhibit defects in cytokine production and impaired proliferative responses in vitro hut the mechanisms underlying this subclinical immune deficiency are controversial, To determine whether abnormalities in the earliest events following receptor engagement may help to explain the in vitro immune dysfunction, we measured the inducibility of the early activation marker CD69 in T cells from asymptomatic HIV-infected individuals in response to stimulation with anti-CD2 or anti-CD3 mAb, In a whole blood assay, we found that induction of CD69 was markedly impaired in CD4(+) T cells from later-stage HIV-infected patients (CD4 counts 200-400/mm(3)) compared to uninfected controls, Among early stage patients (CD4 > 400/mm(3)), a subset (29%) had impaired CD69 induction, CD69 responses were equally depressed after stimulation through the CD3 or CD2 receptor pathways, Survey of a panel of immunophenotypic markers and propensity for apoptosis demonstrated a significant association between depressed induction of CD69 and decreased percentages of CD4(+)CD26(+) and CD4(+) CD95(+) cells but no association with the level of apoptosis. These data indicate that defects in T lymphocyte activation through CD3 and CD2 can he measured within hours of receptor stimulation in asymptomatic HIV-infected individuals and might be useful to monitor as an indicator of immune function in these patients. (C) 1997 Wiley-Liss, Inc. C1 NATL NAVAL MED CTR, IMMUNE CELL BIOL PROGRAM, BETHESDA, MD 20814 USA. HENRY M JACKSON FDN ADV MIL MED, ROCKVILLE, MD USA. NATL NAVAL MED CTR, HENRY M JACKSON FDN, HIV CLIN, BETHESDA, MD USA. WALTER REED ARMY INST RES, DIV RETROVIROL, BETHESDA, MD USA. BECTON DICKINSON IMMUNOCYTOMETRY SYST, SAN JOSE, COSTA RICA. NR 63 TC 24 Z9 26 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0196-4763 J9 CYTOMETRY JI Cytometry PD FEB 15 PY 1997 VL 30 IS 1 BP 1 EP 9 DI 10.1002/(SICI)1097-0320(19970215)30:1<1::AID-CYTO1>3.0.CO;2-R PG 9 WC Biochemical Research Methods; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA WL716 UT WOS:A1997WL71600001 PM 9056736 ER PT J AU Nghiem, SV Martin, S Perovich, DK Kwok, R Drucker, R Gow, AJ AF Nghiem, SV Martin, S Perovich, DK Kwok, R Drucker, R Gow, AJ TI A laboratory study of the effect of frost flowers on C band radar backscatter from sea ice SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID SCATTERING; SURFACE; SNOW AB C band images of Arctic sea ice taken by the ERS 1 synthetic aperture radar show transitory regions of enhanced radar backscatter from young sea ice. Published field observations associate this increase with frost flower growth and the capture of blowing snow by the flowers. To investigate the first part of this phenomenon, we carried out a laboratory experiment on the response of C band radar backscatter to frost flowers growing on the surface of newly formed saline ice. The experiment took place in a 5 m by 7 m by 1.2 m deep saline water pool located in a two-story indoor refrigerated facility at the Cold Regions Research and Engineering Laboratory. Sodium chloride ice was grown in this pool at an air temperature of -28 degrees C, The frost flowers first appeared on the ice surface as dendrites and then changed to needles as the ice sheet grew thicker and the surface temperatures became colder. The frost flowers reached to a height of 10-15 mm, and beneath each cluster of frost flowers a slush layer formed to a thickness of approximately 4 mm. Far-field radar measurements of the backscatter from the ice were made at incident angles from 20 degrees to 40 degrees and at approximately 6-hour intervals throughout the 3-day period of the experiment. A backscatter minimum occurred early in the flower growth at the time coincident with an abrupt doubling in the ice surface salinity. Once the full flower coverage was achieved, we removed first the crystal flowers and then the slush layer from the ice surface. The results for these cases show that the crystals have little impact on the backscatter, while the underlying slush patches yield a backscatter increase of 3-5 dB over that of bare ice. The laboratory results suggest that this relative backscatter. increase of approximately 5 dB can be used as an index to mark the full areal coverage of frost flowers. C1 UNIV WASHINGTON,SCH OCEANOG,SEATTLE,WA 98195. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP Nghiem, SV (reprint author), CALTECH,JET PROP LAB,CTR SPACE MICROELECT TECHNOL,MAIL STOP 300-235,PASADENA,CA 91109, USA. RI Kwok, Ron/A-9762-2008 OI Kwok, Ron/0000-0003-4051-5896 NR 13 TC 21 Z9 21 U1 1 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD FEB 15 PY 1997 VL 102 IS C2 BP 3357 EP 3370 DI 10.1029/96JC03208 PG 14 WC Oceanography SC Oceanography GA WH737 UT WOS:A1997WH73700012 ER PT J AU Barth, J AF Barth, J TI Cyberstocks: An investor's guide to Internet companies - Chai,A SO LIBRARY JOURNAL LA English DT Book Review RP Barth, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD FEB 15 PY 1997 VL 122 IS 3 BP 144 EP 144 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA WG362 UT WOS:A1997WG36200118 ER PT J AU Chandra, S Allik, TH Hutchinson, JA Fox, J Swim, C AF Chandra, S Allik, TH Hutchinson, JA Fox, J Swim, C TI Tunable ultraviolet laser source based on solid-state dye laser technology and CsLiB6O10 harmonic generation SO OPTICS LETTERS LA English DT Article AB Tunable UV radiation centered at 289 nm was obtained from a 532-nm Nd:YAG pumped high-brightness solid-state dye laser, frequency doubled in CsLiB6O10. Frequency doubling to 284-294 nm was demonstrated from a singly doped, rotating pyrromethene dye plastic disk with damage threshold >3 J/cm(2). UV energies up to 44 mJ at 10 Hz were obtained with a 15% absolute conversion efficiency from 532 nm. (C) 1997 Optical Society of America. C1 USA,COMMUN ELECT COMMAND,NIGHT VIS & ELECT SENSORS DIRECTORATE,FT BELVOIR,VA 22060. USA,CHEM & BIOL DEF COMMAND,EDGEWOOD RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP Chandra, S (reprint author), SCI APPLICAT INT CORP,1710 GOODRIDGE DR,MCLEAN,VA 22102, USA. NR 8 TC 22 Z9 23 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD FEB 15 PY 1997 VL 22 IS 4 BP 209 EP 211 DI 10.1364/OL.22.000209 PG 3 WC Optics SC Optics GA WH246 UT WOS:A1997WH24600005 PM 18183152 ER PT J AU Sirenko, YM Jeon, JB Lee, BC Kim, KW Littlejohn, MA Stroscio, MA Iafrate, GJ AF Sirenko, YM Jeon, JB Lee, BC Kim, KW Littlejohn, MA Stroscio, MA Iafrate, GJ TI Hole scattering and optical transitions in wide-band-gap nitrides: Wurtzite and zinc-blende structures SO PHYSICAL REVIEW B LA English DT Review ID MOLECULAR-BEAM EPITAXY; LIGHT-EMITTING-DIODES; SEMICONDUCTOR QUANTUM-WELLS; MONTE-CARLO CALCULATION; III-V-NITRIDE; GALLIUM NITRIDE; ELECTRONIC-STRUCTURE; HEXAGONAL GAN; PRESSURE; MOBILITY AB The energy spectrum and transitions of valence-band carriers in wurtzite materials are studied theoretically using cubic crystals for comparison. We correct the commonly used cubic approximation and propose notations for Luttinger-like parameters in wurtzite structures that simplify the cubic approximation to gamma(1z)=gamma(1 perpendicular to), gamma(2z)=gamma(2 perpendicular to), and gamma(3z)=gamma(3 perpendicular to). We establish the relation between two recently proposed 3x3 matrix blocks diagonalizing the full 6x6 Hamiltonian and provide geometric interpretation in three-dimensional Bloch space. The formalism is used then to derive transition matrix elements for three types of processes: (i) macrofield hole scattering, described by the Bloch overlap factor; (ii) optical transitions between conduction and valence bands; and (iii) intervalence band optical transitions. Finally, we discuss the set of material parameters for group-III nitrides and present the numerical results. C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP N CAROLINA STATE UNIV, DEPT ELECT & COMP ENGN, RALEIGH, NC 27695 USA. NR 108 TC 40 Z9 40 U1 0 U2 10 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD FEB 15 PY 1997 VL 55 IS 7 BP 4360 EP 4375 DI 10.1103/PhysRevB.55.4360 PG 16 WC Physics, Condensed Matter SC Physics GA WK493 UT WOS:A1997WK49300060 ER PT J AU Rudin, S Dyakonov, M AF Rudin, S Dyakonov, M TI Edge and strip plasmons in a two-dimensional electron fluid SO PHYSICAL REVIEW B LA English DT Article ID SEMICONDUCTOR SUPERLATTICE; LATERAL SURFACE; MAGNETOPLASMONS; GAS AB We study plasma oscillations in a bounded two-dimensional electron fluid. The use of a variational method allows a simple analysis of plasma modes in a strip of finite width. For the exactly solvable model that neglects the pressure gradient in a plasma confined to a semi-infinite plane a simple one-parameter variational; function gives the edge plasmon frequency reasonably close to the exact value. In the case of the semi-infinite plane we also incorporate the effects of the pressure gradient in our variational solution. In a two-dimensional strip of finite width we find the symmetric and antisymmetric plasma modes of different frequencies. The method used here can be readily extended to include the effects of applied magnetic fields and different confinement geometries. C1 AF IOFFE PHYS TECH INST,ST PETERSBURG 194021,RUSSIA. RP Rudin, S (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. RI Dyakonov, Michel/I-4836-2013 OI Dyakonov, Michel/0000-0001-6606-4865 NR 12 TC 7 Z9 7 U1 0 U2 4 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD FEB 15 PY 1997 VL 55 IS 7 BP 4684 EP 4688 DI 10.1103/PhysRevB.55.4684 PG 5 WC Physics, Condensed Matter SC Physics GA WK493 UT WOS:A1997WK49300103 ER PT J AU Macucci, M Hess, K Iafrate, GJ AF Macucci, M Hess, K Iafrate, GJ TI Numerical simulation of shell-filling effects in circular quantum dots SO PHYSICAL REVIEW B LA English DT Article ID CAPACITANCE AB We have computed the capacitive energy associated with the addition of each electron to a circular quantum dot, reproducing the shell-filling behavior as reported in previous simulations and recently found experimentally. We derived quantitative estimates for the shape of the confining potential and for the dot radius in the experiments. Our results show that the succession of shell-filling events differs for the case of a realistic self-consistent potential from that predicted by a single-electron approximation and-with an idealized parabolic potential. C1 UNIV ILLINOIS,BECKMAN INST,URBANA,IL 61801. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP Macucci, M (reprint author), UNIV PISA,DIPARTIMENTO INGN INFORMAZ,VIA DIOTISALVI 2,I-56126 PISA,ITALY. NR 11 TC 55 Z9 55 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD FEB 15 PY 1997 VL 55 IS 8 BP R4879 EP R4882 PG 4 WC Physics, Condensed Matter SC Physics GA WL499 UT WOS:A1997WL49900008 ER PT J AU Gaddipati, JP McLeod, DG Sesterhenn, IA Hussussian, CJ Tong, YA Seth, P Dracopoli, NC Moul, JW Srivastava, S AF Gaddipati, JP McLeod, DG Sesterhenn, IA Hussussian, CJ Tong, YA Seth, P Dracopoli, NC Moul, JW Srivastava, S TI Mutations of the p16 gene product are rare in prostate cancer SO PROSTATE LA English DT Article DE prostate cancer; p16; microsatellite; polymerase chain reaction; single strand conformation polymorphism ID KINASE-4 INHIBITOR GENE; CELL-LINES; HOMOZYGOUS DELETION; CDK4 AMPLIFICATION; SOMATIC MUTATIONS; CARCINOMA; PROTEIN; P53; ADENOCARCINOMA; ACCUMULATION AB BACKGROUND. The p16 gene pro-duct isa negative regulator of cell cycle and has been shown to be deleted or mutated in a number of tumor cell lines and primary tumors. The role of p16 in prostate cancer is not defined. Prostate cancer tissues and cell lines were evaluated for pi gene alterations. METHODS. Five metastatic prostate cancer cell lines were analyzed for p16 gene structure and its expression by Southern and Northern blot analyses. Forty-one DNA specimens from 18 microdissected primary tumor specimens, adjacent normal tissues, and cell lines were amplified by polymerase chain reaction for p16 protein coding and splice junction sequences. Mutations were analyzed by single strand conformation polymorphism and DNA sequencing. RESULTS. DU 145 cell line exhibited a missense mutation in codon 84 (GAC to TAC). With the exception of previously reported polymorphism, no mutation was detected in p16 coding or splice junction sequences in primary prostate cancer specimens. CONCLUSIONS. Inactivation of p16 gene by mutations in the protein coding sequence does not play a major role in the genesis of primary prostate cancer. (C) 1997 Wiley-Lies, Inc. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,CTR PROSTATE DIS RES,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. NIH,NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892. NCI,MED BREAST SECT,MED BRANCH,NIH,BETHESDA,MD 20892. NR 32 TC 27 Z9 28 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0270-4137 J9 PROSTATE JI Prostate PD FEB 15 PY 1997 VL 30 IS 3 BP 188 EP 194 PG 7 WC Endocrinology & Metabolism; Urology & Nephrology SC Endocrinology & Metabolism; Urology & Nephrology GA WQ447 UT WOS:A1997WQ44700007 PM 9122044 ER PT J AU James, WF Barko, JW AF James, WF Barko, JW TI Net and gross sedimentation in relation to the phosphorus budget of Eau Galle Reservoir, Wisconsin SO HYDROBIOLOGIA LA English DT Article DE phosphorus; phosphorus budget; retention; sedimentation; sediment traps; sediment cores ID NORTH-TEMPERATE RESERVOIR; LAKES; RETENTION; IRON; PHYTOPLANKTON; RESUSPENSION; DYNAMICS; REDEPOSITION; LOSSES AB We compared P retention with direct measures of P sedimentation, estimated from sediment cores (annual P sedimentation) and sediment traps (daily P sedimentation), to quantify P sedimentation in Eau Galle Reservoir, Wisconsin. Mean annual P retention was similar to mean annual P sedimentation, as estimated from sediment core rates integrated over the entire lake basin, indicating that annual P mass balance approximated annual net P sedimentation in this reservoir. However, sediment trap P rates, measured over the summer stratified period, overestimated P retention rates determined over the same period, suggesting substantial deposition of internally-derived P. Inclusion of measured internal P loadings from a variety of sources in Eau Galle Reservoir in a P mass balance only accounted for an additional 24% of the summer sediment trap P rate, indicating substantial uncertainty in the overall P budget. Imbalances in the P budget may also suggest deposition of sediment from other as yet unquantified internal sources. Potential internal sources of P include sediment resuspension and chemical release and direct uptake of P from the sediment by phytoplankton. RP James, WF (reprint author), USA,ENGINEER WATERWAYS EXPT STN,EAU GALLE AQUAT ECOL LAB,SPRING VALLEY,WI 54767, USA. NR 39 TC 13 Z9 13 U1 0 U2 4 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD FEB 14 PY 1997 VL 345 BP 15 EP 20 DI 10.1023/A:1002979315412 PN 1 PG 6 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA XK537 UT WOS:A1997XK53700002 ER PT J AU Kubek, MJ Shih, TM Meyerhoff, JL AF Kubek, MJ Shih, TM Meyerhoff, JL TI Thyrotropin-releasing hormone (TRH) is markedly increased in the rat brain following soman-induced convulsions SO BRAIN RESEARCH LA English DT Article DE thyrotropin-releasing hormone (TRH); soman; seizure; metabolism; acetylcholine; excitotoxicity; organophosphorus ID INDUCED SEIZURES; NERVE AGENTS; ENZYME; MODULATION; DIAZEPAM; TISSUE; CORTEX AB Soman is an organophosphorus (OP) compound which irreversibly inhibits acetylcholinesterase (AChE), the primary synaptic inactivator of acetylcholine. Resultant excessive cholinergic activity elicits generalized convulsions and brain lesions. Recent evidence suggests that other neurotransmitter/neuromodulator systems may be affected by the OP compounds as well. Since we have shown that both electrically and chemically induced seizures cause significant and prolonged increases in the neuropeptide thyrotropin-releasing hormone (TRH) in epileptogenic sites, we examined soman-induced convulsion effects on CNS TRH. Rats were injected with either soman (100 mu g/kg SC; equivalent to 0.9 LD(50)) or saline and observed for convulsive activity. Forty-eight hours post injection, dramatic increases of TRH over control levels were seen in frontal cortex (30-fold), pooled cortex (24-fold), hippocampus (16-fold), piriform cortex (14-fold), entorhinal cortex (11-fold), and amygdala (2-fold). No change was observed ip either hypothalamus or pituitary. Our results demonstrate, for the first time, a substantial effect of an OP on a specific neuropeptide system in vivo. The neurochemical and behavioral consequences of the soman-induced increases in TRH, especially in the frontal cortex, are presently unknown. Clearly, much more work is required to discern the exact role TRH has following soman exposure. C1 INDIANA UNIV,SCH MED,DEPT PSYCHIAT,INDIANAPOLIS,IN 46202. RL ROUDEBUSH VA MED CTR,INDIANAPOLIS,IN 46202. USA,MED RES INST CHEM DEF,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. WALTER REED ARMY INST RES,DEPT NEUROENDOCRINOL & NEUROCHEM,DIV NEUROSCI,WASHINGTON,DC 20307. RP Kubek, MJ (reprint author), INDIANA UNIV,SCH MED,DEPT ANAT,VANNUYS MED SCI BLDG,635 BARNHILL DR,INDIANAPOLIS,IN 46202, USA. NR 28 TC 8 Z9 8 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD FEB 7 PY 1997 VL 747 IS 2 BP 328 EP 331 DI 10.1016/S0006-8993(96)01315-7 PG 4 WC Neurosciences SC Neurosciences & Neurology GA WJ069 UT WOS:A1997WJ06900019 PM 9046010 ER PT J AU Banks, HT Smith, RC Brown, DE Metcalf, VL Silcox, RJ AF Banks, HT Smith, RC Brown, DE Metcalf, VL Silcox, RJ TI The estimation of material and patch parameters in a PDE-based circular plate model SO JOURNAL OF SOUND AND VIBRATION LA English DT Article ID BEAMS AB The estimation of material and patch parameters for a system involving a circular plate, to which piezoceramic patches are bonded, is considered. A partial differential equation (PDE) model for the thin circular plate is used, with the passive and active contributions from the patches included in the internal and external bending moments. This model contains piecewise constant parameters describing the density, flexural rigidity, Poisson ratio and Kelvin-Voigt damping for the system, as well as patch constants and a coefficient for viscous air damping. Examples demonstrating the estimation of these parameters with experimental acceleration data and a variety of inputs to the experimental plate are presented. By using a physically derived PDE model to describe the system, parameter sets consistent across experiments are obtained, even when phenomena such as damping due to electric circuits affect the system dynamics. (C) 1997 Academic Press Limited. C1 IOWA STATE UNIV SCI & TECHNOL, DEPT MATH, AMES, IA 50011 USA. NASA, LANGLEY RES CTR, LOCKHEED ENGN & SCI CO, HAMPTON, VA 23681 USA. NASA, LANGLEY RES CTR, US ARMY RES LAB, HAMPTON, VA 23681 USA. NASA, LANGLEY RES CTR, ACOUST DIV, HAMPTON, VA 23681 USA. NASA, LANGLEY RES CTR, INST COMP APPLICAT SCI & ENGN, HAMPTON, VA 23681 USA. RP Banks, HT (reprint author), N CAROLINA STATE UNIV, CTR RES SCI COMPUTAT, RALEIGH, NC 27695 USA. NR 21 TC 11 Z9 11 U1 0 U2 0 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-460X J9 J SOUND VIB JI J. Sound Vibr. PD FEB 6 PY 1997 VL 199 IS 5 BP 777 EP 799 DI 10.1006/jsvi.1996.0649 PG 23 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA WG619 UT WOS:A1997WG61900004 ER PT J AU Hemphill, RR Doe, EA AF Hemphill, RR Doe, EA TI Right eye pain and redness - Clinical Pearls - Spontaneous microscopic hyphema. SO ACADEMIC EMERGENCY MEDICINE LA English DT Article DE hyphema; eye; glaucoma; pain; clinical pearl ID TRAUMATIC HYPHEMA; MANAGEMENT C1 BROOKE ARMY MED CTR,DEPT OPHTHALMOL,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,JOINT MIL MED CTR,EMERGENCY MED RESIDENCY,DEPT EMERGENCY MED,SAN ANTONIO,TX. NR 11 TC 0 Z9 0 U1 0 U2 0 PU HANLEY & BELFUS INC PI PHILADELPHIA PA 210 S 13TH ST, PHILADELPHIA, PA 19107 SN 1069-6563 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD FEB PY 1997 VL 4 IS 2 BP 142 EP & DI 10.1111/j.1553-2712.1997.tb03722.x PG 5 WC Emergency Medicine SC Emergency Medicine GA WH441 UT WOS:A1997WH44100012 PM 9043543 ER PT J AU Wongsrichanalai, C Dung, NT Trung, TN Wimonwattrawatee, T Sookto, P Heppner, DG Kawamoto, F AF Wongsrichanalai, C Dung, NT Trung, TN Wimonwattrawatee, T Sookto, P Heppner, DG Kawamoto, F TI In vitro susceptibility of Plasmodium falciparum isolates in Vietnam to artemisinin derivatives and other antimalarials SO ACTA TROPICA LA English DT Article DE malaria; in vitro sensitivity; artemisinin; Viet Nam ID THAILAND; QINGHAOSU AB We performed in vitro drug susceptibility assays of ten Plasmodium falciparum isolates collected from Viet Nam in 1995. All isolates were found to be highly sensitive to artesunate, dihydro-artemisinin and artemisinin. They were also sensitive to quinine. All of them were resistant to chloroquine and mefloquine in vitro. This study provides the baseline estimates of in vitro susceptibility levels of the Vietnamese isolates to artemisinin and their derivatives because the data were collected soon after these drugs were introduced countrywide. It also describes some quantitative profiles of the in vitro response of other standard antimalarial drugs in Viet Nam, which is presently limited. (C) 1997 Elsevier Science B.V. All rights reserved. C1 CTR TROP DIS, Ho Chi Minh City, VIETNAM. SUBINST MALARIOL PARASITOL & ENTOMOL, QUY NHON, VIETNAM. NAGOYA UNIV, SCH MED, DEPT MED ZOOL, NAGOYA, AICHI 466, JAPAN. RP Wongsrichanalai, C (reprint author), ARMED FORCES RES INST MED SCI, 315-6 RAJVITHI RD, BANGKOK 10400, THAILAND. NR 15 TC 18 Z9 18 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X EI 1873-6254 J9 ACTA TROP JI Acta Trop. PD FEB PY 1997 VL 63 IS 2-3 BP 151 EP 158 DI 10.1016/S0001-706X(96)00618-3 PG 8 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA WN687 UT WOS:A1997WN68700008 PM 9088428 ER PT J AU Litvin, AL Valiyaveettil, S Kaplan, DL Mann, S AF Litvin, AL Valiyaveettil, S Kaplan, DL Mann, S TI Template-directed synthesis of aragonite under supramolecular hydrogen-bonded Langmuir monolayers SO ADVANCED MATERIALS LA English DT Article ID INORGANIC MATERIALS; NUCLEATION; CALCIUM; GROWTH; ACID C1 GEOCENTERS INC,NATICK,MA 01760. TUFTS UNIV,CTR BIOTECHNOL,MEDFORD,MA 02155. MAX PLANCK INST POLYMER RES,D-55128 MAINZ,GERMANY. UNIV BATH,SCH CHEM,BATH BA2 7AY,AVON,ENGLAND. RP Litvin, AL (reprint author), USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760, USA. RI Valiyaveettil, Suresh/D-4848-2009; Mann, Stephen/D-1332-2012 OI Valiyaveettil, Suresh/0000-0001-6990-660X; Mann, Stephen/0000-0003-3012-8964 NR 21 TC 155 Z9 157 U1 0 U2 21 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 10 11 61, D-69451 WEINHEIM, GERMANY SN 0935-9648 J9 ADV MATER JI Adv. Mater. PD FEB PY 1997 VL 9 IS 2 BP 124 EP 127 DI 10.1002/adma.19970090205 PG 4 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA WH746 UT WOS:A1997WH74600003 ER PT J AU Thomson, GM Pochan, CA Markland, RA Thomson, SA AF Thomson, GM Pochan, CA Markland, RA Thomson, SA TI Near real-time mass concentration measurement of medium and heavy elements in aerosols using X-ray fluorescence SO AMERICAN INDUSTRIAL HYGIENE ASSOCIATION JOURNAL LA English DT Article DE aerosols; heavy elements; X-ray fluorescence AB A new aerosol monitor rapidly measures the mass concentration of individual elements with atomic number Z>20 in dust- or smoke-laden air. The device separates the aerosol's nongaseous components by pumping the air through a section of a filter paper tape. After gathering particles for a fixed period of time, pumping stops and the tape advances, forcing a new section to intercept the airstream and bringing the exposed section in front of a 25 mCi (milli Curies) Cd-109 radioactive source. The source bombards the tape's contents with 22 keV (kilo-electron-Volts) X- rays. These, in turn, induce fluorescence in the trapped atoms; that is, they cause the atoms to emit X-rays of their own at lower but still easily measurable (if Z>20), characteristic energies. An analysis of the latter's X-ray energy spectrum provides raw data revealing the identity and abundance of each corresponding element in the aerosol simultaneously. Note that the X-ray fluorescence method is independent of the stale of chemical combination of the species in question. A prototype device has been tested using deployed uranium and iron aerosols and prepared calibration deposits containing the elements U, Cr, Ph Hg, W,Br, l, Mo, Cu, Zn, Fe, and As. With the exception of iodine, it readily measured levels corresponding to mass concentrations of a few lens of mu g/m(3)! or less in 10 minutes. At mass concentrations in the few mg/m(3) range, measurement times of a minute or less were easily achieved. This sensitivity, coupled with its ease of calibration, straightforward data analysis, and basic simplicity make the instrument suitable for many applications, especially those involving field work. C1 HAZARDOUS & MED WASTE SVCS INC,ABERDEEN PROVING GROUND,MD 21005. USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. RP Thomson, GM (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 9 TC 5 Z9 5 U1 0 U2 2 PU AMER INDUSTRIAL HYGIENE ASSOC PI FAIRFAX PA 2700 PROSPERITY AVE #250, FAIRFAX, VA 22031-4307 SN 0002-8894 J9 AM IND HYG ASSOC J JI Am. Ind. Hyg. Assoc. J. PD FEB PY 1997 VL 58 IS 2 BP 98 EP 104 DI 10.1202/0002-8894(1997)058<0098:NRMCMO>2.0.CO;2 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA WH445 UT WOS:A1997WH44500003 ER PT J AU Caretti, DM AF Caretti, DM TI Cognitive performance during long term respirator wear while at rest SO AMERICAN INDUSTRIAL HYGIENE ASSOCIATION JOURNAL LA English DT Article DE cognitive performance; reaction time; respirator wear ID MASK AB Cognitive performance was studied in six male and three female subjects exposed to two randomly administered 10-hour measurement periods, a control condition without a respirator, and a respirator wear trial requiring continuous wear, under nonexercise conditions. Reaction time and decision-making speed were assessed using a series of simple and choice reaction time tasks at the start of each test iteration and after hours 2, 4, 6, 8, and 10 of testing. Subject anxiety levels were assessed along with reaction time measures. Visual tracking ability was measured after each hour of testing. Reaction time and decision-making speed did not differ significantly between control and respirator conditions at any time throughout the 10 hours of resting. Female volunteers exhibited significantly faster reaction times and decision-making speeds than males independent of respirator wear conditions and time of measurement. Subject anxiety increased significantly from initial measurements after 8 hours of testing for each condition, but no differences were observed between conditions at any time. Respirator wear did not detrimentally influence visual tracking ability. These findings suggest that respirator wear over a relatively long time period under nonexercise conditions should not significantly inhibit cognitive function. RP Caretti, DM (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,RESP & COLLECT PROTECT TEAM,ABERDEEN PROVING GROUND,MD 21010, USA. NR 20 TC 8 Z9 8 U1 1 U2 1 PU AMER INDUSTRIAL HYGIENE ASSOC PI FAIRFAX PA 2700 PROSPERITY AVE #250, FAIRFAX, VA 22031-4307 SN 0002-8894 J9 AM IND HYG ASSOC J JI Am. Ind. Hyg. Assoc. J. PD FEB PY 1997 VL 58 IS 2 BP 105 EP 109 DI 10.1202/0002-8894(1997)058<0105:CPDLRW>2.0.CO;2 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA WH445 UT WOS:A1997WH44500004 PM 9042703 ER PT J AU Adera, T Gaydos, JC AF Adera, T Gaydos, JC TI Identifying comparison groups for evaluating occupational hearing loss: A statistical assessment of 22 industrial populations SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE hearing loss; comparison groups; statistical evaluation; occupation; NIOSH ID CONSERVATION PROGRAMS AB Finding appropriate comparison groups to study occupational hearing loss has been difficult. Recently, however; the National Institute far Occupational Safety and Health sponsor-ed the compilation of potentially useful data for 22 diverse industrial companies in the U.S.A. and Canada. We conducted a statistical evaluation to determine which of the 22 populations might be suited as comparison groups in future studies of workers exposed to hazardous noise. In a Cox Proportional Hazards model that included age and sex, the relative risk of developing hearing loss in each company was estimated at two, Jive, and ten years of follow-up. We ranked the companies based on their relative risks, and rated them on a five-point scale from om ''excellent'' to ''poor'' to indicate their suitability as comparison groups. The risk profiles developed and other variables described in this study will assist researchers in selecting appropriate comparison groups for evaluating occupational hearing loss. (C) 1997 Wiley-Liss,Inc. C1 USA,CTR HLTH PROMOT & PREVET MED,ABERDEEN PROVING GROUND,MD. RP Adera, T (reprint author), VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,1008 E CLAY ST,POB 980212,RICHMOND,VA 23298, USA. NR 11 TC 8 Z9 8 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0271-3586 J9 AM J IND MED JI Am. J. Ind. Med. PD FEB PY 1997 VL 31 IS 2 BP 243 EP 249 DI 10.1002/(SICI)1097-0274(199702)31:2<243::AID-AJIM14>3.0.CO;2-1 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA WF879 UT WOS:A1997WF87900014 PM 9028441 ER PT J AU Gorbunov, NV Elsayed, NM Kisin, ER Kozlov, AV Kagan, VE AF Gorbunov, NV Elsayed, NM Kisin, ER Kozlov, AV Kagan, VE TI Air blast-induced pulmonary oxidative stress: Interplay among hemoglobin, antioxidants, and lipid peroxidation SO AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY LA English DT Article DE blast overpressure; lung injury; antioxidant depletion; prooxidants; hemoglobin oxidation ID HYDROGEN-PEROXIDE; FREE-RADICALS; REPERFUSION INJURY; IN-VIVO; PROTECTIVE MECHANISM; ALPHA-TOCOPHEROL; ASCORBIC-ACID; REDOX STATES; MYOGLOBIN; OXYGEN AB Blast overpressure (BOP) is a phenomenon that describes the instantaneous rise in atmospheric pressure above ambient, resulting from the firing of large caliber weapons or from military or civilian explosions. Exposure to BOP results in injury to the gas-filled organs, such as the lungs, which exhibit a contusion-type injury. We examined the effects of BOP in rats at 5 and 60 min after exposure to a low-level BOP (62 +/- 3 kPa). The exposure was found to cause oxidative stress in the lung that was characterized by 1) a 3.5-fold decrease in total antioxidant reserves, 2) a depletion of the major water-soluble antioxidants ascorbate and glutathione (GSH) by 50 and 75%, respectively, 3) a depletion of lipid-soluble antioxidant vitamin E by 30%, 4) a 2.5-fold increase of fluorescent end products of lipid peroxidation, and 5) an increased methemoglobin (metHb) content at 60 min after exposure. To elucidate the role of released hemoglobin (Hb) in blast-induced oxidative stress, we studied the interactions of oxyhemoglobin (oxyHb), metHb, and the oxoferryl from of Hb free radical species with two physiologically important reductants, ascorbate and GSH. We found that both ascorbate and GSH were able to convert oxyHb to metHb in a reaction that yielded the one-electron oxidation intermediates semidehydro-ascorbyl radical and glutathionyl radical, respectively. This reaction did not occur under anaerobic conditions, suggesting that oxyHb-bound O-2 acted as the electron acceptor. OxyHb induced peroxidation of cis-parinaric acid in the presence but not absence of ascorbate or GSH. Thus the prooxidant action of water-soluble antioxidants via redox cycling of oxyHb and metHb may promote oxidative stress rather than prevent it. C1 UNIV PITTSBURGH, DEPT ENVIRONM & OCCUPAT HLTH, PITTSBURGH, PA 15238 USA. UNIV CALIF LOS ANGELES, DEPT ENVIRONM & OCCUPAT HLTH, LOS ANGELES, CA 90024 USA. RP Gorbunov, NV (reprint author), WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT RESP RES, DIV MED, WASHINGTON, DC 20307 USA. NR 67 TC 41 Z9 42 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1040-0605 J9 AM J PHYSIOL-LUNG C JI Am. J. Physiol.-Lung Cell. Mol. Physiol. PD FEB PY 1997 VL 272 IS 2 BP L320 EP L334 PG 15 WC Physiology; Respiratory System SC Physiology; Respiratory System GA WJ524 UT WOS:A1997WJ52400019 PM 9124384 ER PT J AU Smoak, BL DeFraites, RF Magill, AJ Kain, KC Wellde, BT AF Smoak, BL DeFraites, RF Magill, AJ Kain, KC Wellde, BT TI Plasmodium vivax infections in US Army troops: Failure of primaquine to prevent relapse in studies from Somalia SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POLYMERASE CHAIN-REACTION; MALARIA; FALCIPARUM; DIAGNOSIS AB Different strains of Plasmodium vivax vary in their sensitivity to primaquine, the only drug that prevents relapses. Described are the clinical data and relapse pattern for 75 soldiers treated for vivax malaria since returning from Somalia. Following their initial attack of malaria, 60 of the 75 cases received a standard course of primaquine (15 mg base daily for 14 days). Twenty-six of the 60 soldiers subsequently relapsed for a failure rate of 43%. Eight soldiers had a second relapse following primaquine therapy after both the primary attack and first relapse. Three of these soldiers had received a higher dosage of primaquine (30 mg base daily for 14 days) after their second attack. The apparent ineffectiveness of primaquine therapy in preventing relapses suggests the presence of primaquine-resistant* P. vivax strains in Somalia. C1 TORONTO HOSP,TROP DIS UNIT,TORONTO,ON M5G 2C4,CANADA. WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP Smoak, BL (reprint author), WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 25 TC 51 Z9 54 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1997 VL 56 IS 2 BP 231 EP 234 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA WP436 UT WOS:A1997WP43600021 PM 9080885 ER PT J AU Schlagenhauf, P Lobel, H Steffen, R Johnson, R Popp, K Tschopp, A Letz, R Crevoisier, C AF Schlagenhauf, P Lobel, H Steffen, R Johnson, R Popp, K Tschopp, A Letz, R Crevoisier, C TI Tolerance of mefloquine by SwissAir trainee pilots SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID BEHAVIORAL-EVALUATION; PROPHYLAXIS; SYMPTOMS; MALARIA; REGIMENS; EXPOSURE; SYSTEM; TERM AB Due to presumed adverse performance impact, a World Health Organization clause currently restricts the use of mefloquine malaria chemoprophylaxis in individuals requiring fine coordination and spatial discrimination. We conducted a double-blind, placebo-controlled, cross-over study to quantitatively assess the effects of mefloquine at steady state on performance in 23 trainee airline pilots. Flying performance was assessed using a flight simulator, psychomotor function was evaluated, sleep and wake cycles were monitored, and symptoms and moods were assessed using standardized questionnaires. A simplified postural sway meter recorded sway in three test positions. In the mefloquine loading dose phase, there was one withdrawal due to dizziness, diarrhea, and flu-like symptoms, and three volunteers reported nonserious, sleep-related adverse events. There was no significant difference in flying performance, psychomotor functions, or mean sway for any test position. Nonsignificant reductions in mean total nocturnal sleep (mefloquine = 450 min versus placebo = 484 min) and poorer sleep quality were detected in the mefloquine phases. The mood findings indicated a predominance of positive states, with vigor the predominant mood in all phases. No significant performance deficit was documented under laboratory conditions during use of mefloquine at steady state. C1 CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV PARASIT DIS,ATLANTA,GA 30333. USA,ENVIRONM MED RES INST,NATICK,MA 01760. UNIV ZURICH,INST SOCIAL & PREVENT MED,DIV BIOSTAT,CH-8006 ZURICH,SWITZERLAND. WALTER REED ARMY INST RES,DEPT BEHAV BIOL,WASHINGTON,DC 20307. EMORY UNIV,ROLLINS SCH PUBL HLTH,ATLANTA,GA 30322. F HOFFMANN LA ROCHE & CO LTD,DEPT CLIN PHARMACOL,CH-4002 BASEL,SWITZERLAND. RP Schlagenhauf, P (reprint author), UNIV ZURICH,INST SOCIAL & PREVENT MED,DIV COMMUNICABLE DIS,SUMATRASTR 30,CH-8006 ZURICH,SWITZERLAND. NR 29 TC 31 Z9 31 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1997 VL 56 IS 2 BP 235 EP 240 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA WP436 UT WOS:A1997WP43600022 PM 9080886 ER PT J AU Karan, SM Lojeski, EW AF Karan, SM Lojeski, EW TI Femoral venous carbon dioxide pressure (PCO2) is a better diagnostic sign than arterial PCO2 for slowly progressing MH in swine SO ANESTHESIA AND ANALGESIA LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT ANESTHESIOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307. NR 3 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 1997 VL 84 SU 2 BP S245 EP S245 PG 1 WC Anesthesiology SC Anesthesiology GA WF780 UT WOS:A1997WF78000245 ER PT J AU Stevens, JB Vescovo, MV Harris, KC Walker, SC Hickey, R AF Stevens, JB Vescovo, MV Harris, KC Walker, SC Hickey, R TI Tracheal intubation without muscle relaxant: Is propofol required? SO ANESTHESIA AND ANALGESIA LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT ANESTHESIOL,SAN ANTONIO,TX. UNIV TEXAS,HLTH SCI CTR,DEPT ANESTHESIOL,SAN ANTONIO,TX 78284. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 1997 VL 84 SU 2 BP S27 EP S27 PG 1 WC Anesthesiology SC Anesthesiology GA WF780 UT WOS:A1997WF78000027 ER PT J AU Norton, SA Burdick, AE Phillips, CM Berman, B AF Norton, SA Burdick, AE Phillips, CM Berman, B TI Teledermatology and underserved populations SO ARCHIVES OF DERMATOLOGY LA English DT Article ID HEALTH-CARE; TECHNOLOGY AB Background: The dermatologic needs of many communities in the United States and worldwide are underserved Telemedicine enables physicians and nonphysician primary care providers to use modern telecommunications devices to gain access to specialist consultations promptly and with much less travel. The independently developed telemedicine programs described herein support 3 traditionally underserved populations: Pacific Islanders, migrant farmworkers, and prison inmates. Observations: In 3 independently designed telemedicine programs, dermatology emerged as the specialty most used by remote practitioners. Patients were presented for both diagnosis and treatment and in the setting of initial evaluation and as part of follow-up care. Conclusion: Teledermatology is a useful way to provide dermatologic support to remote or underserved communities. C1 TRIPLER ARMY MED CTR,DERMATOL SERV,DEPT MED,HONOLULU,HI 96859. UNIV MIAMI,SCH MED,DEPT DERMATOL & CUTANEOUS SURG,MIAMI,FL. E CAROLINA UNIV,DEPT MED,DERMATOL SERV,GREENVILLE,NC 27834. NR 9 TC 61 Z9 62 U1 1 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD FEB PY 1997 VL 133 IS 2 BP 197 EP 200 DI 10.1001/archderm.133.2.197 PG 4 WC Dermatology SC Dermatology GA WH067 UT WOS:A1997WH06700009 PM 9041833 ER PT J AU Lee, MH Durnford, SJ Crowley, JS Rupert, AH AF Lee, MH Durnford, SJ Crowley, JS Rupert, AH TI Visual vestibular interaction in the dynamic visual acuity test during voluntary head rotation SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID OCULAR REFLEX; MOVEMENTS; COORDINATION; OSCILLOPSIA; FREQUENCY; VELOCITY AB Background: Although intact vestibular function is indispensable to maintaining spatial orientation, no good screening tests of vestibular function are implemented in the aviation community. High frequency voluntary head rotation was selected as a vestibular stimulus to isolate the vestibule-ocular reflex (VOR) from visual influence. Method: A dynamic visual acuity test that incorporates voluntary head rotation was evaluated as a potential vestibular function screening tool: 27 normal subjects performed voluntary sinusoidal head rotation at frequencies from 0.7-4 Hz under 3 different visual conditions: visually-enhanced VOR, normal VOR, and visually suppressed VOR. Standardized Bailey-Lovie chart letters were presented on a computer monitor in front of the subject, who then was asked to read the letters while rotating his head horizontally. The electro-oculogram and dynamic visual acuity score were recorded and analyzed. Results: There was no significant difference in gain or phase shift among 3 visual conditions in the frequency range 2.8-4 Hz. The dynamic visual acuity score shifted less than 0.3 log MAR at frequencies under 2.0 Hz. Conclusion: The dynamic visual acuity test at frequencies around 2 Hz can be recommended for evaluating vestibular function. C1 USA,AEROMED RES LAB,FT RUCKER,AL. USN,AEROSP MED RES LAB,PENSACOLA,FL. RP Lee, MH (reprint author), ROKAF,AEROMED RES INST,POB 335-18,NAMIL MYUN,CHEUNGWON GUN 363849,CHUNGBUK,SOUTH KOREA. NR 25 TC 15 Z9 18 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 1997 VL 68 IS 2 BP 111 EP 117 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA WG529 UT WOS:A1997WG52900004 PM 9125086 ER PT J AU Naseem, SM Creasia, DA AF Naseem, SM Creasia, DA TI Comparative binding and toxicity of saxitoxin and saxitoxinol in mice and in cultured cells SO BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL LA English DT Article DE receptor binding; neuroblastoma; saxitoxin; saxitoxinol, cultured cells ID SQUID AXON; PRODUCTS; MUSCLE; TOXINS AB The binding characteristics of saxitoxin (STX), a known voltage-gated sodium channel blocker, and its analog saxitoxinol (STXOL), were studied in neuroblastoma, peritoneal macrophage, hepatocytes and PC-12 cell lines. H-3-STXOL bound to the cell-surface sites which appear to be the same as those occupied by H-3-STX and which can, therefore, be identified as STX receptors. The relative agreement of respective K-d obtained by saturation, competition, association and dissociation kinetics for STX and STXOL suggest the absence of any artifact in binding measurements. Unlike STX, STXOL was non-toxic to mice by intratracheal instillation. The major advantage of using 3H-STXOL is that the tritium label is not exchangeable. Data from this study suggest that 3H-STXOL can be used to identify STX receptors at 37 degrees C. RP Naseem, SM (reprint author), USA,MED RES INST INFECT DIS,FREDERICK,MD 21702, USA. NR 16 TC 1 Z9 1 U1 1 U2 2 PU ACADEMIC PRESS AUST PI MARRICKVILLE PA LOCKED BAG 16, MARRICKVILLE NSW 2204, AUSTRALIA SN 1039-9712 J9 BIOCHEM MOL BIOL INT JI Biochem. Mol. Biol. Int. PD FEB PY 1997 VL 41 IS 2 BP 377 EP 388 PG 12 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA WM103 UT WOS:A1997WM10300018 PM 9063578 ER PT J AU Abugo, OO Macdonald, VW Berger, RL Hess, JR AF Abugo, OO Macdonald, VW Berger, RL Hess, JR TI Manometric measurements of oxygen binding by whole blood and hemoglobin solutions. SO BIOPHYSICAL JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,BLOOD RES DETACHMENT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOPHYSICAL SOCIETY PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD FEB PY 1997 VL 72 IS 2 BP MP348 EP MP348 PN 2 PG 1 WC Biophysics SC Biophysics GA WE747 UT WOS:A1997WE74700480 ER PT J AU Abugo, OO Macdonald, VW Rudolph, AS Hess, JR Balagopalakrishna, C Rifkind, JM AF Abugo, OO Macdonald, VW Rudolph, AS Hess, JR Balagopalakrishna, C Rifkind, JM TI Measurements of free and encapsulated hemoglobin oxidation by EPR spectroscopy. SO BIOPHYSICAL JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,BLOOD RES DETACHMENT,WASHINGTON,DC. USN,RES LAB,CTR BIOMOL SCI & ENGN,WASHINGTON,DC 20375. NIA,NATL INST HLTH,CTR GERONTOL RES,BALTIMORE,MD 21224. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOPHYSICAL SOCIETY PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD FEB PY 1997 VL 72 IS 2 BP MAMF2 EP MAMF2 PN 2 PG 1 WC Biophysics SC Biophysics GA WE747 UT WOS:A1997WE74700044 ER PT J AU Foltz, JA Franklin, K Zahwa, HS Chavez, MD Berger, RL AF Foltz, JA Franklin, K Zahwa, HS Chavez, MD Berger, RL TI Enthalpy changes of the step-wise ligation of hemoglobin. SO BIOPHYSICAL JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,BLOOD RES DETACHMENT,WASHINGTON,DC 20307. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BIOPHYSICAL SOCIETY PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD FEB PY 1997 VL 72 IS 2 BP MP340 EP MP340 PN 2 PG 1 WC Biophysics SC Biophysics GA WE747 UT WOS:A1997WE74700473 ER PT J AU Musselman, LJ Bray, RD Knepper, DA AF Musselman, LJ Bray, RD Knepper, DA TI Isoetes x carltaylorii (Isoetes acadiensis x Isoetes engelmannii), a new interspecific quillwort hybrid from the Chesapeake Bay SO CANADIAN JOURNAL OF BOTANY-REVUE CANADIENNE DE BOTANIQUE LA English DT Article DE Isoetes saccharata var. reticulata; Isoetes riparia; Isoetes saccharata; megaspores; tidal freshwater rivers ID FRESH-WATER SWAMPS; NORTH-AMERICA; MORPHOLOGY AB Isoetes acadiensis Kott is a plant of the Maritime provinces of Canada and the northeastern United States. In the Chesapeake Bay region, this quillwort has previously been misidentified as Isoetes riparia Engelm., Isoetes saccharata Engelm., or Isoetes saccharata var. reticulata A.A. Eaten. Isoetes xcarltaylorii hyb.nov. is the hybrid between I. acadiensis (2n = 44) and Isoetes engelmannii A. Braun (2n = 22). This is the first report of a hybrid with I. acadiensis. An apparently sterile triploid (2n = 33), this rare plant of freshwater tidal marshes has the predicted range of sizes and megaspore features of a hybrid. This brings to 14 the number of interspecific quillwort hybrids described from North America since 1985. C1 USA,CORPS ENGINEERS,NORFOLK,VA 23510. RP Musselman, LJ (reprint author), OLD DOMINION UNIV,DEPT BIOL SCI,NORFOLK,VA 23529, USA. NR 21 TC 5 Z9 9 U1 1 U2 1 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4026 J9 CAN J BOT JI Can. J. Bot.-Rev. Can. Bot. PD FEB PY 1997 VL 75 IS 2 BP 301 EP 309 PG 9 WC Plant Sciences SC Plant Sciences GA XD784 UT WOS:A1997XD78400011 ER PT J AU Lee, JW Yeomans, WG Allen, AL Kaplan, DL Deng, F Gross, RA AF Lee, JW Yeomans, WG Allen, AL Kaplan, DL Deng, F Gross, RA TI Exopolymers from curdlan production: Incorporation of glucose-related sugars by Agrobacterium sp. strain ATCC 31749 SO CANADIAN JOURNAL OF MICROBIOLOGY LA English DT Article DE Agrobacterium sp.; curdlan; exopolymer; 3-O-methyl-D-glucose; 2-acetamido-2-deoxy-D-glucose ID XANTHOMONAS-CAMPESTRIS; XANTHAN GUM; POLYSACCHARIDE AB Three different exopolymers were purified from cultures of Agrobacterium sp. strain ATCC 31749 grown in a mineral salts medium containing 2% glucose at 30 degrees C for 5 days under aerobic culture conditions. These exopolymers were curdlan (extracellular, homo-beta-(1-3)-glucan, water insoluble at neutral pH), a water-soluble noncurdlan-type exopolymer A (WSNCE-A), and a water-soluble noncurdlan-type exopolymer B (WSNCE-B). Curdlan, WSNCE-A, and WSNCE-B composed by weight 61, 27, and 12%, respectively, of the exopolymer produced from glucose. Compositions of all polymers were confirmed by gas chromatography (GC) and gas chromatography - mass spectrometry (GC-MS). The WSNCE-A is composed of glucose and galactose with lower contents of rhamnose. The WSNCE-B consists of glucose and mannose. To biosynthesize modified biopolymers, glucose-related sugars including 3-O-methyl-D-glucose, 2-amino-2-deoxy-D-glucose, and 2-acetamido-2-deoxy-D-glucose (N-acetylglucosamine) were fed separately as the sole carbon source. Using 3-O-methyl-D-glucose, 8-12 mol% of the curdlan repeats were 3-O-methyl-D-glucose based on GC and H-1-nuclear magnetic resonance spectrometry. N-Acetylglucosamine was incorporated into WSNCE-A at 10 mol% based on the CC-MS but was not found in curdlan or WSNCE-B. C1 TUFTS UNIV,CTR BIOTECHNOL,MEDFORD,MA 02155. UNIV LOWELL,DEPT CHEM,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 37 TC 13 Z9 13 U1 0 U2 4 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4166 J9 CAN J MICROBIOL JI Can. J. Microbiol. PD FEB PY 1997 VL 43 IS 2 BP 149 EP 156 PG 8 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology; Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology; Microbiology GA XB723 UT WOS:A1997XB72300006 ER PT J AU Lorbe, DI Strauss, AM AF Lorbe, DI Strauss, AM TI Survey of oral appliance practice among dentists treating obstructive sleep apnea patients SO CHEST LA English DT Article DE dentists; obstructive sleep apnea; oral appliance; polysomnography AB Purpose: Oral appliances (OAs) are used to treat obstructive sleep apnea (OSA). This study seeks to quantify the patterns of practice of OA use among dentists. Design: Survey mailed to dentists. Participants: Members of the Sleep Disorders Dental Society (SDDS). Measurements: Dentists were asked questions regarding number of patients treated, types of OA used, average total OB cost to the patient excluding reimbursement, percentages of patients receiving pretreatment and posttreatment nocturnal polysomnography (NPSG), and whether they believe subjective patient reports alone or nocturnal pulse oximetry alone is an adequate substitute for NPSG to assess OSA treatment response. Summary statistics for the absolute value and percentage data are presented with the median, maximum, and minimum range. Results: Three hundred fifty-five surveys were mailed, of which 124 (35%) were returned. These dentists treat a median of 27 OSA patients with OAs (range, 2 to 300) annually. Patients receive pretreatment NPSG in 95% of cases (range, 0 to 100%), and posttreatment NPSG in 18% of cases (range, 0 to 100%). Only 7% of dentists believe subjective patient reports alone are an adequate substitute for NPSG. Nocturnal pulse oximetry was perceived to be an adequate substitute for NPSG by 37%. Dentists who believe nocturnal pulse oximetry to be an adequate substitute for posttreatment NPSG are less likely to obtain pretreatment or posttreatment NPSG (Mann-Whitney U test, two-tailed; p=0.001, p=0.02). Conclusions: ii-lost SDDS dentists believe subjective reports and nocturnal pulse oximetry are inadequate to assess OA treatment response in OSA patients, yet posttreatment PSG is obtained infrequently. C1 CROZER CHESTER MED CTR,SLEEP DISORDERS CTR,UPLAND,PA. RP Lorbe, DI (reprint author), WALTER REED ARMY MED CTR,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 20 TC 0 Z9 1 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD FEB PY 1997 VL 111 IS 2 BP 382 EP 386 PG 5 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA WH304 UT WOS:A1997WH30400027 ER PT J AU Loube, MDI AF Loube, MDI TI Treatment algorithm for OSA SO CHEST LA English DT Letter ID OBSTRUCTIVE SLEEP-APNEA; WEIGHT-LOSS RP Loube, MDI (reprint author), WALTER REED ARMY MED CTR,PULM & CRIT CARE MED SERV,SLEEP DISORDERS CTR,WASHINGTON,DC 20307, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD FEB PY 1997 VL 111 IS 2 BP 528 EP 528 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA WH304 UT WOS:A1997WH30400061 ER PT J AU Stojadinovic, A Kiang, J Goldhill, J Matin, D Smallridge, R Galloway, R SheaDonohue, T AF Stojadinovic, A Kiang, J Goldhill, J Matin, D Smallridge, R Galloway, R SheaDonohue, T TI Induction of the heat shock response prevents tissue injury during acute inflammation of the rat ileum SO CRITICAL CARE MEDICINE LA English DT Article DE ricin; hyperthermia; ileitis; heat shock; neutrophil; leukotrienes ID AGE-DEPENDENT RESPONSE; TUMOR-NECROSIS-FACTOR; ACUTE LUNG INJURY; BOWEL-DISEASE; TRANSLATIONAL THERMOTOLERANCE; ADRENAL-CORTEX; STRESS PROTEIN; CELLS; LEUKOTRIENE-B4; EXPRESSION AB Objectives: To determine if prior total body hyperthermia protected against subsequent acute ileitis induced by the cytotoxic lectin, ricin, in rats. The time course of heat shock mRNA and protein expression in the ileum was determined. The effects of heat stress on small intestinal mucosal integrity, arachidonic acid metabolism, and neutrophilic infiltrate were compared in heated and nonheated rats receiving vehicle or ricin intraluminally. The effect of hyperthermia on the circulating neutrophil superoxide production was also evaluated. Design: Prospective, randomized, controlled trial. Setting: University research laboratory. Subjects: Forty-one adult, male Sprague-Dawley rats, weighing 150 to 250 g, and 32 adult, inbred, male Fisher 344 rats, weighing 175 to 250 g. Interventions: Exposure to whole body hyperthermia and production of acute ileitis. Sprague-Dawley rats were divided randomly into four experimental groups: nonheated control group, heated control group, nonheated ricin group (1 mg/mL water, intraluminal), and heated ricin group. Sprague-Dawley rats in a separate study were assigned to seven groups based on the time of removal of the terminal ileum following hyperthermia: 0 min, or 1, 2, 4, 8, 12, and 24 hrs. Inbred Fisher 344 rats were allocated to the heated and nonheated groups for peripheral neutrophil superoxide generation studies. Measurements and Main Results: Whole body hyperthermia to a rectal temperature of 41 degrees C to 42 degrees C for 15 to 20 mins: a) was associated with marked mucosal cytoprotection against subsequent ricin-induced ileitis (Injury grade [from 0 = normal to 5 = severe]: 0.4 +/- 0.1 vs. 2.5 +/- 0.2, p<.001); b) prevented the ricin-induced reduction in villus height to crypt depth ratio (2.4 +/- 0.1 vs. 1.9 +/- 0.1, p <.01); and c) significantly reduced the number of infiltrating neutrophils when compared with nonheated ricin-treated rats (11 +/- 2 vs. 32 +/- 3 neutrophils/high-power field, p<.001). The hyperthermia-induced peak increase in heat shock protein (HSP)-70 mRNA at 2 hrs preceded that of HSP 70i at 4 hrs. Heat shock significantly reduced the ricin-induced increase in both basal (8.0 +/- 1.9 vs. 33.0 +/- 8.1 pg of leukotriene B-4/mg protein, p<.05) and ionophore-stimulated (16.0 +/- 4.9 vs. 80.0 +/- 15.5 pg of leukotriene B-4/mg protein, p <.001) generation of ileal leukotriene B-4, but did not alter the cyclooxygenase product, prostaglandin E(2). Hyperthermia did not alter peripheral neutrophil superoxide production. Conclusions: This study assessed the effects of heat shock in the normal and acutely inflamed intestine. These data suggest that heat stress and increased expression of HSP 70i protect against acute intestinal inflammation. This protection is associated with significant reductions in ileal leukotriene B-4 generation and neu trophilic infiltrate. Hyperthermia did not alter circulating neutrophil superoxide production. Thus, the mechanism of heat stress protection against acute ileitis may involve local intestinal inhibition of leukotriene B-4 production and subsequent neutrophilic infiltration without altering the ability of systemic neutrophils to be activated. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC 20307. NR 37 TC 27 Z9 33 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD FEB PY 1997 VL 25 IS 2 BP 309 EP 317 DI 10.1097/00003246-199702000-00020 PG 9 WC Critical Care Medicine SC General & Internal Medicine GA WJ268 UT WOS:A1997WJ26800021 PM 9034270 ER PT J AU Cockerham, KP Kennerdell, JS AF Cockerham, KP Kennerdell, JS TI Orbital disease, optic nerve and chiasm SO CURRENT OPINION IN NEUROLOGY LA English DT Review ID GRAVES OPHTHALMOPATHY; WEGENERS GRANULOMATOSIS; DIDMOAD SYNDROME; MR; MANIFESTATIONS; MALFORMATIONS; INFLAMMATION; VASCULATURE; ORBITOPATHY; VISION AB The diagnosis and management of diseases of the orbit, optic nerve and chiasm continue to evolve. Advances in neuroradiology are remarkable and continue to expand diagnosis and management. This review will highlight the clinical assessment of disease, orbital and neuroimaging, medical and surgical management. C1 ALLEGHENY UNIV HLTH SCI,DEPT OPHTHALMOL,PITTSBURGH,PA. RP Cockerham, KP (reprint author), WALTER REED ARMY MED CTR,GEORGIA AVE NW,WASHINGTON,DC 20037, USA. NR 45 TC 3 Z9 3 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 1350-7540 J9 CURR OPIN NEUROL JI Curr. Opin. Neurol. PD FEB PY 1997 VL 10 IS 1 BP 22 EP 30 DI 10.1097/00019052-199702000-00006 PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA WQ731 UT WOS:A1997WQ73100006 PM 9099523 ER PT J AU Chung, AD English, JC AF Chung, AD English, JC TI Cutaneous hyperpigmentation and polyglandular autoimmune syndrome type II SO CUTIS LA English DT Review ID ACUTE ADRENAL INSUFFICIENCY; ADDISONS-DISEASE; FAILURE AB Primary adrenal insufficiency (Addison's disease) may initially present with cutaneous hyperpigmentation. Addison's disease, when associated with autoimmune thyroid disease and/or insulin-dependent diabetes mellitus, is referred to as polyglandular autoimmune syndrome type II. We present the case of a patient who initially was diagnosed as having Grave's disease and eventually Addison's disease due to persistent cutaneous hyperpigmentation, fatigue, weight loss, hypotension, hyponatremia, peripheral eosinophilia, and positive results of a synthetic corticotropin stimulation test. Addison's disease, polyglandular autoimmune syndrome type II, and cutaneous hyperpigmentation are reviewed. C1 BROOKE ARMY MED CTR,DEPT DERMATOL,FT SAM HOUSTON,TX 78234. DARNALL ARMY COMMUNITY HOSP,DEPT MED,FT HOOD,TX. NR 18 TC 5 Z9 5 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD FEB PY 1997 VL 59 IS 2 BP 77 EP 80 PG 4 WC Dermatology SC Dermatology GA XB126 UT WOS:A1997XB12600005 PM 9040976 ER PT J AU Davis, WM Cespedes, ER Lee, LT Powell, JF Goodson, RA AF Davis, WM Cespedes, ER Lee, LT Powell, JF Goodson, RA TI Rapid delineation of subsurface petroleum contamination using the site characterization and analysis penetrometer system SO ENVIRONMENTAL GEOLOGY LA English DT Article DE petroleum wastes; laser-induced fluorescence; cone penetrometer; in-situ sensors AB The Site Characterization and Analysis Penetrometer System (SCAPS) was used to investigate subsurface petroleum contamination at Aberdeen Proving Ground, Maryland. The SCAPS is a rapid site-screening tool developed by the Tri-Services (U.S. Army, Navy, and Air Force) to reduce the cost of installation restoration activities. The system, consisting of a geophysical cone penetrometer fitted with a laser-induced fluorescence petroleum sensor, is capable of simultaneous, real-time delineation of subsurface stratigraphy and petroleum contaminant distribution. The site investigation described herein successfully identified three distinct areas of subsurface petroleum contamination caused by leaking underground storage tanks containing No. 2 heating oil. The SCAPS petroleum sensor response was verified by obtaining 20 soil samples and performing onsite and conventional laboratory analyses for petroleum contaminants. Verification sample results indicate a strong correlation between the SCAPS fluorescence data and conventional measures of petroleum contamination. This investigation illustrates the capabilities of the SCAPS for rapid site characterization. C1 USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. NR 16 TC 5 Z9 5 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0177-5146 J9 ENVIRON GEOL JI Environ. Geol. PD FEB PY 1997 VL 29 IS 3-4 BP 228 EP 237 PG 10 WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources SC Environmental Sciences & Ecology; Geology; Water Resources GA WN751 UT WOS:A1997WN75100010 ER PT J AU Li, AZ Marx, KA Walker, J Kaplan, DL AF Li, AZ Marx, KA Walker, J Kaplan, DL TI Trinitrotoluene and metabolites binding to humic acid SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID BIOLOGICAL DEGRADATION; CHEMICAL-AGENTS; EXPLOSIVES; SUBSTANCES AB Systematic studies were conducted to observe the binding interactions between the class of compounds including nitroaromatic munitions pollutants trinitrotoluene (TNT) and certain of its breakdown products and dissolved Aldrich humic acid (HA), which is used as a model soil matrix. Equilibrium dialysis followed by HPLC quantitation was used to determine the effect of ligand concentration, HA concentration, pH, and ionic strength on the formation kinetics and ligand binding level of the ligand-HA complex. It was found that TNT and its byproducts 2,6-diamino-4-nitrotoluene (2,6DAmNT) and 2-amino-4,6-dinitrotoluene (2AmDNT) are all able to bind to HA at different binding levels in a slow kinetic process. The HA concentration was observed to have the same inverse effect on the binding of bath TNT and 2,6DAmNT, while pH had opposite effects on binding for the two compounds. Nearly a 2-fold increase in binding of TNT to HA was observed for a 5-fold increase in ionic strength of phosphate buffer. A linear binding model represented the best fit for the 2,6DAmNT isotherm data while the Langmuir model best fit the TNT isotherms. The maximum binding density of TNT for HA calculated from the Langmuir model ranged from 6 to 30 mu M TNT/mu M HA of average size 5000 for all conditions studied. These facts suggest that the binding mechanisms are different for the above two ligands due to their different chemical structures. C1 UNIV LOWELL,DEPT CHEM,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 20 TC 44 Z9 44 U1 1 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB PY 1997 VL 31 IS 2 BP 584 EP 589 DI 10.1021/es960486c PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA WG343 UT WOS:A1997WG34300061 ER PT J AU Parker, MF Arroyo, GF Geradts, J Sabichi, AL Park, RC Taylor, RR Birrer, MJ AF Parker, MF Arroyo, GF Geradts, J Sabichi, AL Park, RC Taylor, RR Birrer, MJ TI Molecular characterization of adenocarcinoma of the cervix SO GYNECOLOGIC ONCOLOGY LA English DT Article ID HUMAN PAPILLOMAVIRUS DNA; SQUAMOUS-CELL CARCINOMA; RAS GENE-MUTATIONS; UTERINE CERVIX; ENDOMETRIAL CARCINOMA; P53 MUTATIONS; LOW-FREQUENCY; RB GENE; CANCER; EXPRESSION AB In an attempt to characterize the molecular alterations of cervical adenocarcinoma, we analyzed 32 paraffin-embedded specimens for the presence of K-ras mutations, p53 overexpression, p16 and Rb protein expression, and the presence of HPV 16 and 18 DNA, Overall 25/32 (78%) of the tumors displayed an abnormality in at least one of these analyses. K-ras mutations were detected by PCR amplification and RFLP analysis in 3 tumors, including 2 at codon 12 and 1 at codon 61. p53 overexpression determined by immunohistochemistry was demonstrated with >80% of tumor nuclei staining in 4 cases, 10-15% of nuclei staining in 3 cases, and <1% of nuclei staining in 5 cases. The pattern of staining was diffuse in 6 cases, focal in 1 case, and scattered in 5 cases, Analysis of p16 protein expression in 23 specimens revealed 1 tumor with abnormal staining, while Rb protein expression was determined to be normal in all 25 tumors tested. HPV DNA, detected by PCR with type-specific primers, was found in 16 tumors (50%), including 7 (22%) with HPV 16 and 9 (28%) with HPV 18, There was no correlation among these abnormalities except that the presence of HPV and strong p53 overexpression (>80% tumor nuclei staining) were mutually exclusive events. Clinical correlation demonstrated that p53 overexpression involving the majority of tumor cell nuclei is characteristic of advanced stage disease, while HPV positivity and activated ras genes are associated with early stage disease. (C) 1997 Academic Press. C1 NCI,PREVENT RES BRANCH,DIV CLIN SCI,ROCKVILLE,MD 20850. UNIV N CAROLINA,DEPT PATHOL,CHAPEL HILL,NC 27514. RP Parker, MF (reprint author), WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL GYNECOL ONCOL,WASHINGTON,DC 20307, USA. NR 39 TC 48 Z9 51 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD FEB PY 1997 VL 64 IS 2 BP 242 EP 251 DI 10.1006/gyno.1996.4580 PG 10 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA WK990 UT WOS:A1997WK99000009 PM 9038270 ER PT J AU Jones, JR Tait, GB Jones, SH Katzer, DS AF Jones, JR Tait, GB Jones, SH Katzer, DS TI DC and large-signal time-dependent electron transport in heterostructure devices: An investigation of the heterostructure barrier varactor (vol 42, pg 1393, 1995) SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Correction C1 UNIV VIRGINIA, DEPT ELECT ENGN, CHARLOTTESVILLE, VA 22903 USA. US MIL ACAD, DEPT ELECT & COMP SCI, W POINT, NY 10996 USA. VIRGINIA COMMONWEALTH UNIV, DEPT ELECT ENGN, RICHMOND, VA 23284 USA. UNIV VIRGINIA, DEPT ELECT ENGN, CHARLOTTESVILLE, VA 22903 USA. USN, RES LAB, DIV ELECT SCI & TECHNOL, WASHINGTON, DC 20375 USA. RI Katzer, D. Scott/N-7841-2013 NR 1 TC 0 Z9 0 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD FEB PY 1997 VL 44 IS 2 BP 350 EP 350 DI 10.1109/TED.1997.557735 PG 1 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA WD598 UT WOS:A1997WD59800022 ER PT J AU Katulka, GL AF Katulka, GL TI Parametric study of high energy plasmas for electrothermal-chemical propulsion applications SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE capillary; ionized gas; plasma; polyethylene; propulsion; pulsed power AB Theoretical calculations are performed with a one-dimensional (1-D), steady state, isothermal computer plasma model to define plasma output parameters for various input electrical energies and capillary radii of relevance to the electrothermal-chemical (ETC) propulsion concept, Three capillaries of 1.92, 4.75, and 7.0 mm radius, and a fixed length of 11.84 cm, were chosen for this study with input currents between 30 and 350 kA, Plasmas are categorized according to their total power and energy levels (based on a 3-ms pulse width) and are compared with respect to their resistance, exit pressure, and core plasma temperature, The input power ranges from 0.17 to 1.89 GW, for input energies from 0.49 to 5.80 MJ, which is considered suitable coverage for ETC ignition through ETC enhanced propulsion concepts, The study shows that the range of resistance, pressure, and temperature are 12.8-195 m Omega, 19.8-2000 MPa, and 2.9-13.5 eV, respectively, for the chosen capillary geometry, Flow conditions for plasma calculations include choked (no pressure boundary) and unchoked (450-MPa pressure boundary) for some calculations, Results from the computational model and interpretations from the perspective of capillary implementation into ETC propulsion concepts are also included. RP Katulka, GL (reprint author), USA,RES LAB,WEAPONS TECHNOL DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005, USA. NR 13 TC 7 Z9 7 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD FEB PY 1997 VL 25 IS 1 BP 66 EP 72 DI 10.1109/27.557487 PG 7 WC Physics, Fluids & Plasmas SC Physics GA WL611 UT WOS:A1997WL61100009 ER PT J AU Zhang, JW Gorkovenko, A Gross, RA Allen, AL Kaplan, D AF Zhang, JW Gorkovenko, A Gross, RA Allen, AL Kaplan, D TI Incorporation of 2-hydroxyl fatty acids by Acinetobacter calcoaceticus RAG-1 to tailor emulsan structure SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES LA English DT Article DE Acinetobacter calcoaceticus RAG-1; emulsan; hydroxyfatty acid ID ARTHROBACTER RAG-1; EMULSIFIER; OIL AB Acinetobacter calcoaceticus RAG-1 was cultured on different chain length saturated 2-hydroxyl fatty acid (2-HOFA) carbon sources as follows: C12:0 (2-OH), C14:0 (2-OH), C16:0 (2-OH) and C18:0 (2-OH). These 2-HOFAs were used as either sole carbon sources or cosubstrates with C14:0 (total 1% w/v) to form new emulsans (EMs) having controlled side chain FA structure and, therefore, unique emulsifier characteristics. EM yields and cell dry weights ranged from 0.6 to 1.8 g/l and 0.9 to 3.9 g/l, respectively, depending on the carbon source(s) and the cultivation conditions. The content of C12:0 (2-OH) EM substituents reached high levels (306 nmol/mg-EM, 64.4 mol% of total FAs) by selectively feeding this FA. Substantial quantities of 2-HOFAs with chain lengths greater than or equal to C14-up to 96 nmol/mg-EM or 15.2 mol% for C16:0 (2-OH)-were also incorporated in EMs by providing the corresponding 2-HOFA carbon source in the medium. By increasing the medium 2-HOFA concentration large increases in EM total FA contents resulted. The EM FA content was as high as 955 nmol/mg-EM or 23 wt% for a culture containing 0.75 g/100 ml C18:0 (2-OH). An important metabolic pathway involved in EM side chain formation from C16:0 (2-OH) and C18:0 (2-OH) involves decarboxylation, oxidation of the alkanol to the corresponding n - 1 FA-CoA intermediate and formation of odd chain length substituent side chain linkages by an EM acyl transferase. Addition of the enzyme alkylating agent iodoacetamide to cultures was used to: (i) enhance the incorporation into EMs of both C12:0 (2-OH) and C16:0 (2-OH) substituents; and (ii) increase by 1.3 to 1.8 fold (by wt.) the total EM FA content. Finally, it was concluded that enhanced emulsification activity of EMs is not necessarily achieved by forming products with relatively high 2- and 3-hydroxydodecanoic acid contents. (C) 1997 Elsevier Science Ireland Ltd. C1 UNIV LOWELL,DEPT CHEM,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. RI Zhang, Jinwen/G-8674-2014 OI Zhang, Jinwen/0000-0001-8828-114X NR 22 TC 20 Z9 24 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0141-8130 J9 INT J BIOL MACROMOL JI Int. J. Biol. Macromol. PD FEB PY 1997 VL 20 IS 1 BP 9 EP 21 DI 10.1016/S0141-8130(97)01147-1 PG 13 WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science SC Biochemistry & Molecular Biology; Chemistry; Polymer Science GA WT319 UT WOS:A1997WT31900002 PM 9110181 ER PT J AU Smith, KJ Nelson, A Skelton, H Yeager, J Wagner, KF AF Smith, KJ Nelson, A Skelton, H Yeager, J Wagner, KF TI Pityriasis lichenoides et varioliformis acuta in HIV-1+ patients: A marker of early stage disease SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID MUCHA-HABERMANN DISEASE; T-CELL; SUPERANTIGENS; IMMUNOFLUORESCENCE; ASSOCIATION; INFECTION; SKIN AB Background The high incidence of cutaneous disease in HIV-1+ patients may be a marker of the chronic state of immune activation. In addition, specific cutaneous diseases may be related to the pattern and degree of immune dysregulation present in the patients at the time of the eruption. We have observed that HIV-1+ patients with pityriasis lichenoides et varioliformis acuta (PLEVA) were in the early to midstage of HIV-1 disease. Materials and methods To determine if there was a correlation between the phenotype of the lymphoid infiltrate and surface markers of the epidermis and the known changes in early or late-stage HIV-1 disease, we studied five HIV-1+ patients with PLEVA. Cutaneous biopsy specimens were obtained and immunohistochemical stains were used to determine the expression of ELAM-1, ICAM-1, and HLA-DR and the phenotype of the lymphoid infiltrate. Results The HIV-1+ patients showed increased expression of HLA-DR on keratinocytes as well as on the mononuclear and dendritic cell populations in the epidermis and dermis. The majority of T cells were activated CD8+ cells. Conclusions Immunophenotyping of the inflammatory infiltrate in these patients is consistent with a pattern of immune dysregulation seen only in earlier stages of HIV-I disease. Thus, PLEVA may be useful as a marker of early to midstages of HIV-I disease. C1 ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20306 USA. ARMED FORCES INST PATHOL, AIDS REGISTRY, WASHINGTON, DC 20306 USA. USA, MED RES INST CHEM DEF, ABERDEEN PROVING GROUND, MD 21010 USA. NATL NAVAL MED CTR, BETHESDA, MD USA. NR 23 TC 16 Z9 17 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA P O BOX 88, OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0NE SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD FEB PY 1997 VL 36 IS 2 BP 104 EP 109 DI 10.1046/j.1365-4362.1997.00006.x PG 6 WC Dermatology SC Dermatology GA WR982 UT WOS:A1997WR98200005 PM 9109005 ER PT J AU Kokidko, D Gee, L Chou, SC Chiang, FP AF Kokidko, D Gee, L Chou, SC Chiang, FP TI Method for measuring transient out-of-plane deformation during impact SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE experimental; transient; moire; method; impact phenomena; composite material AB There is no standard methodology to measure the transient deformation of a material under impact. High speed photography can be used to capture the deformation but is limited to one projected plane of view. The knowledge of the entire deformed field and its time history of a material is of great interest to many researchers. This investigation will employ a shadow moire and high speed photography method by which the entire deformation history of the surface can be measured. Shadow moire Is a technique to measure out-of-plane displacement using a linear grating and the interference fringe patterns that occur during deformation are recorded using a high speed camera. The recorded fringe patterns are enhanced and processed with a data analysis code to map out the history of the displacement field of the entire rear surface of the target during the impact. Copyright (C) 1996 Elsevier Science Ltd. C1 SUNY STONY BROOK,STONY BROOK,NY 11794. RP Kokidko, D (reprint author), USA,RES LAB,MAT DIRECTORATE,WATERTOWN,MA 02172, USA. NR 14 TC 9 Z9 12 U1 2 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD FEB PY 1997 VL 19 IS 2 BP 127 EP 133 DI 10.1016/S0734-743X(96)00010-3 PG 7 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA WC433 UT WOS:A1997WC43300005 ER PT J AU Zandi, B Merkle, LD Gruber, JB Wortman, DE Morrison, CA AF Zandi, B Merkle, LD Gruber, JB Wortman, DE Morrison, CA TI Optical spectra and analysis for Pr3+ in SrAl12O19 SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ROOM-TEMPERATURE; STIMULATED-EMISSION; CRYSTALS; IONS AB Energy levels of the 4f(2) electronic configuration of Pr3+ in SrAl12O19 (SAM) have been determined from polarized absorption and fluorescence spectra using crystals, charge-compensated with Mg2+, at temperatures between about 20 and 300 K. Energy level assignments were made initially by comparing the crystal spectra with energy levels calculated by using crystal-field parameters, B-km, compatible with those previously reported for Nd3+ in SAM. The B-km were varied to obtain a best fit between experimental and theoretical energies, and the final values: B-20=-94, B-40=1047, B-60=-1397, and B-66=-1245 cm(-1) give an rms fit of 14.5 cm(-1). The B-km for Pr3+ in SAM were also used along with a result relating the B-km to crystal-field components, A(nm), derived in a lattice sum calculation to obtain B-km values for all the triply ionized rare-earth ions in SAM. Odd-fold A(km) are also given that are required in the intensity and lifetime calculations and yield results in good agreement with the measurements. In addition, the results of our energy level fitting were useful in estimating absorption and emission cross sections, as well as lifetimes and branching ratios, for the Various J multiplets. The evidence given here that the room temperature fluorescence quantum efficiency of P-3(0) in lightly doped Pr in SAM is near unity strengthens the case that this is a potentially useful laser material. The theoretical model and method of analysis used is useful for the calculation of energy levels, wave functions, transition probabilities, etc., for any rare-earth RE(3+) ion in any host of known crystal structure. (C) 1997 American Institute of Physics. C1 SAN JOSE STATE UNIV,DEPT PHYS,SAN JOSE,CA 95192. USA,RES LAB,ADELPHI LAB CTR,ADELPHI,MD 20783. RP Zandi, B (reprint author), ARL SENSORS & ELECT DEV DIRECTORATE,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 15 TC 15 Z9 17 U1 1 U2 10 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 1 PY 1997 VL 81 IS 3 BP 1047 EP 1054 DI 10.1063/1.363886 PG 8 WC Physics, Applied SC Physics GA WF017 UT WOS:A1997WF01700004 ER PT J AU Cornelison, SG Gauss, A Krane, J Hardy, JR AF Cornelison, SG Gauss, A Krane, J Hardy, JR TI Centimeter-wave reflection in the nitrates and nitrites of sodium and potassium: Experiment and theory SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID PHASE-TRANSITIONS; FERROELECTRICITY; ORIGIN; BATIO3; KNO3 AB Temperature-dependent centimeter-wave reflection is studied in powdered samples of potassium nitrate (KNO3), potassium nitrite (KNO2), sodium nitrate (NaNO3), and sodium nitrite (NaNO2). Temperature-dependent reflection measurements at centimeter-wave frequencies were performed on an HP8510B Network analyzer based reflectometer. These measurements are compared to calculations utilizing a Debye relaxation model. Reflection losses seen in KNO2 and NaNO2 are expected to be due to the presence of permanent dipoles that are excited to ''hopping'' modes as the temperature is raised. Although NaNO3 shows little reflection losses, KNO3 shows significant losses as the temperature is raised toward the order/disorder transition temperature of 128 degrees C. This is believed to be due to the development of ''induced'' dipole moments as the lattice becomes increasingly disordered. (C) 1997 American Institute of Physics. C1 UNIV NEBRASKA,DEPT PHYS,LINCOLN,NE 68588. UNIV NEBRASKA,CTR ELECTROOPT,LINCOLN,NE 68588. RP Cornelison, SG (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 13 TC 2 Z9 2 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 1 PY 1997 VL 81 IS 3 BP 1451 EP 1456 DI 10.1063/1.364182 PG 6 WC Physics, Applied SC Physics GA WF017 UT WOS:A1997WF01700070 ER PT J AU Nirdnoy, W Serichantalergs, O Cravioto, A LeBron, C Wolf, M Hoge, CW Svennerholm, AM Taylor, DN Echeverria, P AF Nirdnoy, W Serichantalergs, O Cravioto, A LeBron, C Wolf, M Hoge, CW Svennerholm, AM Taylor, DN Echeverria, P TI Distribution of colonization factor antigens among enterotoxigenic Escherichia coli strains isolated from patients with diarrhea in Nepal, Indonesia, Peru, and Thailand SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID PREVALENCE; CHILDREN; PCF8775; E8775 AB Samples (1,318) of enterotoxigenic Escherichia coli (ETEC) isolated in 1994-1995 from children with diarrhea from Nepal, Indonesia, Peru, and Thailand were examined for colonization factor antigen (CFA) and coli surface (CS) antigens. Fifty-five percent of 361 heat-labile and heat-stable (LT-ST), 14% of 620 LT-only, and 18% of 337 ST-only ETEC had CFA/CS antigens, LT-ST ETEC strains were predominantly in the CFA II group, and ST only strains were in the CFA IV group. Additional studies are needed to identify ETEC strains that do not have CFA/CS antigens. C1 ARMED FORCES RES INST MED SCI, DEPT BACTERIOL IMMUNOL & MOL GENET, BANGKOK 10400, THAILAND. NATL AUTONOMOUS UNIV MEXICO, FAC MED, MEXICO CITY 04510, DF, MEXICO. NAVAL MED RES UNIT 2, JAKARTA, INDONESIA. WALTER REED ARMY INST RES, WASHINGTON, DC USA. GOTHENBURG UNIV, DEPT MED MICROBIOL & IMMUNOL, S-41346 GOTHENBURG, SWEDEN. NAVAL MED RES INST DETACHMENT, LIMA, PERU. NR 21 TC 15 Z9 17 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD FEB PY 1997 VL 35 IS 2 BP 527 EP 530 PG 4 WC Microbiology SC Microbiology GA WD082 UT WOS:A1997WD08200045 PM 9003636 ER PT J AU Byrd, JC Weiss, RB Arthur, DC Lawrence, D Baer, MR Davey, F Trikha, ES Carroll, AJ Tantravahi, R Qumsiyeh, M Patil, SR Moore, JO Mayer, RJ Schiffer, CA Bloomfield, CD AF Byrd, JC Weiss, RB Arthur, DC Lawrence, D Baer, MR Davey, F Trikha, ES Carroll, AJ Tantravahi, R Qumsiyeh, M Patil, SR Moore, JO Mayer, RJ Schiffer, CA Bloomfield, CD TI Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21)(q22;q22): Results from cancer and leukemia group B 8461 SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article; Proceedings Paper CT 36th Annual Meeting of the American-Society-of-Hematology CY DEC 02-06, 1994 CL NASHVILLE, TN SP Amer Soc Hematol ID ACUTE MYELOGENOUS LEUKEMIA; ACUTE MYELOID-LEUKEMIA; ACUTE NONLYMPHOCYTIC LEUKEMIA; GRANULOCYTIC SARCOMA CHLOROMA; ACUTE MYELOBLASTIC-LEUKEMIA; CELL-ADHESION MOLECULE; 8-21 TRANSLOCATION; CLINICAL-FEATURES; POOR PROGNOSIS; CLASSIFICATION AB Purpose: To examine the prognostic significance of extramedullary leukemia (EML) at presentation in patients with t(8;21)(q22;q22) karyotype. Patients and Methods: Consecutive patients with t(8;21) treated on Cancer and Leukemia Group 8 de novo acute myeloid leukemia (AML) treatment studies were examined for the presence of EML (granulocytic sarcoma, subcutaneous nodules, leukemia cutis, or meningeal leukemia) at initial presentation, Clinical features and outcome of t(8;21) patients with and without EML were compared. Results: Of 84 patients with t(8;21), eight (9.5%) had EML manifesting as granulocytic sarcoma (five paraspinal, one breast, and one subcutaneous) or symptomatic meningeal leukemia (n = 1). The pretreatment prognostic variables of t(8;21) patients with and without EML were similar. The hematologic complete remission (CR) rate for t(8;21) patients with EML was 50% versus 92% for those without EML (P = .006), The median CR duration for EML patients was 14.7 months. patients with EML had a shorter survival (P = 0.002, median 5.4 months versus 59.5 months). This poor outcome may relate to inadequate local (radiation or intrathecal) therapy for patients with spinal or meningeal EML, resulting in residual/recurrent EML following induction chemotherapy (n = 2) or at relapse (n = 1) and permanent neurologic deficits (n = 4). Only one of the EML patients received high-dose cytarabine (HDAC) intensification; this is the only EML patient remaining alive in CR. Conclusion: Patients with t(8;21) and EML have a low CR rate and overall survival, An aggressive local and systemic induction therapy should be considered for this patient subset, The effectiveness of HDAC intensification in t(8;21) patients with EML is uncertain and warrants further study. (C) 1997 by American Society of Clinical Oncology. C1 CANC & LEUKEMIA GRP B,CHICAGO,IL. ROSWELL PK CANC INST,BUFFALO,NY 14263. RP Byrd, JC (reprint author), WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. FU PHS HHS [26806, 59518, 37027] NR 51 TC 139 Z9 144 U1 1 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD FEB PY 1997 VL 15 IS 2 BP 466 EP 475 PG 10 WC Oncology SC Oncology GA WG098 UT WOS:A1997WG09800009 PM 9053467 ER PT J AU Smith, KJ Casillas, R Graham, J Skelton, HG Stemler, F Hackley, BE AF Smith, KJ Casillas, R Graham, J Skelton, HG Stemler, F Hackley, BE TI Histopathologic features seen with different animal models following cutaneous sulfur mustard exposure SO JOURNAL OF DERMATOLOGICAL SCIENCE LA English DT Article DE sulfur mustard; animal models; bullae ID INDUCED SKIN IRRITATION; KERATINOCYTES; PIG; PERMEABILITY; INFLAMMATION; EXPRESSION; COMPONENTS; MECHANISMS; INTEGRINS; INVITRO AB In an effort to understand the pathophysiology of sulfur mustard (2,2' dichlorodiethyl sulfide, HD)-induced cutaneous lesions, a number of animal models have been used. Animal models have been and will continue to be used in the development of therapeutic strategies to protect against and/or moderate lesions, and to potentiate wound healing after HD exposure. Upon reviewing the histopathologic features seen after I-ID-exposure, we propose roles for different animal models in I-ID-research. Hematoxylin and eosin slides from protocols done originally as dose response studies for either liquid or vapor HD-exposures were examined. The animal models reported include the hairless guinea pig (HGP), weanling pig (WP), mouse ear (ME) and hairless mouse (HM). In all these animal models, HD induces subepidermal blister formation as well as epidermal cell death. The HGP appears to be the most sensitive model for epidermal necrosis. The HGP and, to a lesser degree, the HM react with a marked neutrophilic infiltrate. The ME provides a quantitative measure for HD effects and a mild inflammatory infiltrate similar to what is seen in human skin. Doses necessary to produce microblister formation in the WP are usually associated with more significant stromal and vascular changes than in other animal models. In addition to a quantitative measure of the HD effect and a mild inflammatory response, the cost, as well as the availability of specific antibodies, and DNA and RNA probes and primers gives the ME advantages for both drug screening and for the study of the pathophysiology of HD-induced cutaneous lesions. The sensitivity of the HGP and the abundant experience with vapor exposures establishes a place for this animal model in barrier cream and drug screening. The similarity of WP skin to human skin is important in the study of wound healing after HD exposure, as well as in the study of the pathophysiology of the cutaneous lesion and in more definitive therapeutic studies. C1 USA, MED RES INST CHEM DEF, ABERDEEN, MD 20306 USA. ARMED FORCES INST PATHOL, WASHINGTON, DC USA. NATL NAVAL MED CTR, BETHESDA, MD USA. NR 27 TC 66 Z9 67 U1 0 U2 1 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0923-1811 J9 J DERMATOL SCI JI J. Dermatol. Sci. PD FEB PY 1997 VL 14 IS 2 BP 126 EP 135 DI 10.1016/S0923-1811(96)00560-9 PG 10 WC Dermatology SC Dermatology GA WJ582 UT WOS:A1997WJ58200005 PM 9039976 ER PT J AU Washowich, TL Williams, SC Richardson, LA Simmons, GE Dao, NV Allen, TW Hammet, GC Morris, MJ AF Washowich, TL Williams, SC Richardson, LA Simmons, GE Dao, NV Allen, TW Hammet, GC Morris, MJ TI Detection of interstitial lung abnormalities on picture archive and communication system video monitors SO JOURNAL OF DIGITAL IMAGING LA English DT Article DE picture archive and communication systems; computers; interstitial lung disease ID RADIOGRAPHY; RESOLUTION; DISEASE AB The purpose of this study was to compare the detection of interstitial lung abnormalities on video display workstation monitors between radiologists experienced with video image interpretation and radiologists who lack this experience. Twenty-four patients with interstitial lung abnormalities documented by high-resolution computed tomagraphy (HRCT) and lung biopsy, and 26 control patients with no history of pulmonary disease or a normal HRCT and normal chest radiographs were studied, Images were acquired using storage phosphor digital radiography and displayed on 1.645-2,0498 pixel resolution video monitors, Five board-certified radiologists evaluated the images in a blinded and randomized manner by using a six-point presence of abnormality grading scale. Three radiologists were from 1 to 4 years out of residency and considered to be experienced workstation monitor readers with between 1 to 3 years of video monitor image interpretation. For the inexperienced readers, one radiologist bad no prior experience with reading images front a video monitor and was direct out of residency, and ti-re other radiologist had less than 4 months of intermittent exposure and was 1 year out of residency. Sensitivity and specificity were determined for individual readers. Positive predictive values, negative predictive values, accuracy, and receiver-operating curves were also generated. A comparison was made between experienced and inexperienced readers, Far readers experienced with video monitor image interpretation, the sensitivity ranged from 87.5% to 92%, specificity from 69% to 92%, positive predictive value (PPV) from 73% to 87.5%, negative predictive value (NPV) from 87% to 90%, and accuracy from 80% to 88%. For inexperienced readers, these values were sensitivity 58%, specificity 50% to 65%, PPV 52% to 61%, NPV 56.5% to 63% and accuracy 54% to 62%. Comparing image interpretation between experienced and inexperienced readers, there were statistically significant differences far sensitivity (P <.01), specificity (P <.01), PPV (P <.05), NPV (P <05), accuracy (P <.05), and area under the receiver operator curve (Az) (P <.01). Within the respective experienced and inexperienced groups, no statistical significant differences were present. Our results show that digitally acquired chest radiographs displayed on high-resolution workstation monitors are adequate for the detection of interstitial lung abnormalities when the images are interpreted by radiologists experienced with Yideo image interpretation. Radiologists inexperienced with video monitor image interpretation, however, cannot reliably interpret images for the detection of interstitial lung abnormalities. Copyright (C) 1937 by W.B. Saunders Company. C1 BROOKE ARMY MED CTR,DEPT PULM MED,FT SAM HOUSTON,TX 78234. MADIGAN ARMY MED CTR,DEPT RADIOL,FT LEWIS,WA. WILFORD HALL USAF MED CTR,DEPT RADIOL,SAN ANTONIO,TX 78236. RP Washowich, TL (reprint author), BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 5 Z9 5 U1 1 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0897-1889 J9 J DIGIT IMAGING JI J. Digit. Imaging PD FEB PY 1997 VL 10 IS 1 BP 34 EP 39 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA WL602 UT WOS:A1997WL60200006 PM 9147526 ER PT J AU Lakhani, H Hoover, E AF Lakhani, H Hoover, E TI Child care use, earnings, and retention desires of wives of employees - US Army officers' study SO JOURNAL OF ECONOMIC PSYCHOLOGY LA English DT Article DE child care; commissioned officers; earnings; retention ID UNITED-STATES-ARMY; MULTIDISCIPLINARY ANALYSIS; CHOICE; MODEL; DETERRENCE; DECISIONS; COSTS AB The employment of both civilian and United States Army wives has been significant and growing. In this paper, we outline a theory of rational choice and a balanced satisfaction model to predict employment decisions made by couples in alternative employment settings. We hypothesize positive inter-relationships between the four criterion variables of earnings of wives of U.S. Army officers, their use of child care services, their satisfaction with Army life, and their desires for the Army's retention of their husbands. 1986 data for wives of U.S. Army officers from the Sun:ev of Army Families (N = 669) are used to estimate a system of four simultaneous equations. The results reveal that the four criteria are positively related to one another. In particular, the satisfaction-balance model was supported because an increase in a wife's earnings was positively associated with her satisfaction with Army life and her dissatisfaction with the cost of child care services was negatively related to her satisfaction with Army life. An increase in her satisfaction with Army life was positively associated with her desire for Army's retention of her husband. Implications of these results are discussed in the context of predictors of the four criterion variables. C1 GEORGE WASHINGTON UNIV,WASHINGTON,DC 20052. RP Lakhani, H (reprint author), USA,RES INST BEHAV & SOCIAL SCI,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 38 TC 0 Z9 0 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-4870 J9 J ECON PSYCHOL JI J. Econ. Psychol. PD FEB PY 1997 VL 18 IS 1 BP 87 EP 110 DI 10.1016/S0167-4870(96)00048-7 PG 24 WC Economics; Psychology, Multidisciplinary SC Business & Economics; Psychology GA WJ718 UT WOS:A1997WJ71800005 ER PT J AU Bernstein, SA Williford, SL AF Bernstein, SA Williford, SL TI Intranasal desmopressin-associated hyponatremia: A case report and literature review SO JOURNAL OF FAMILY PRACTICE LA English DT Article; Proceedings Paper CT 89th Annual Scientific Assembly of the Southern-Medical-Association CY NOV 15-19, 1995 CL KANSAS CITY, MO SP So Med Assoc, Sect Neurosurg, So Med Assoc, Sect Pathol, So Med Assoc, Sect Otolaryngol Head & Neck Surg DE desmopressin; water intoxication; hyponatremia; enuresis ID NOCTURNAL ENURESIS; WATER-INTOXICATION; SEIZURES; DDAVP; CONVULSION; ACETATE; ADULT AB We present a case of a 29-year-old woman with a long history of nocturnal enuresis who developed symptomatic hyponatremia from water intoxication shortly after beginning desmopressin. A MEDLINE search in the English language revealed 13 prior case reports. All patients presented with seizure, mental status changes, or both. Two distinct presentations occurred: one group of patients maintained a stable course with desmopressin and developed symptoms related to an outside factor. The other group of patients were new to desmopressin and had a profound water intoxication response from its use. While the underlying cause was from simple overhydration, the quickness of this unanticipated adverse effect is noteworthy. The importance of counseling to ensure a family's and a patient's understanding of the effects of desmopressin as well as monitoring electrolytes periodically may help identify and prevent this serious iatrogenic complication. C1 WOMACK ARMY MED CTR,DEPT FAMILY PRACTICE,FT BRAGG,NC. NR 21 TC 33 Z9 33 U1 0 U2 1 PU APPLETON & LANGE PI E NORWALK PA 25 VAN ZANT ST, E NORWALK, CT 06855 SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD FEB PY 1997 VL 44 IS 2 BP 203 EP 208 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA WH210 UT WOS:A1997WH21000011 PM 9040524 ER PT J AU Artenstein, AW VanCott, TC Sitz, KV Robb, ML Wagner, KF Veit, SCD Rogers, AF Garner, RP Byron, JW Burnett, PR Birx, DL AF Artenstein, AW VanCott, TC Sitz, KV Robb, ML Wagner, KF Veit, SCD Rogers, AF Garner, RP Byron, JW Burnett, PR Birx, DL TI Mucosal immune responses in four distinct compartments of women infected with human immunodeficiency virus type 1: A comparison by site and correlation with clinical information SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Eighth Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS CY FEB 11-15, 1996 CL BETHESDA, MD ID CERVICOVAGINAL SECRETIONS; PAROTID-SALIVA; IGA ANTIBODIES; HIV-INFECTION; GP160; AIDS; IMMUNOGLOBULINS; PROTEIN; SMOKERS; SERUM AB Because mucosal immune responses may be important in protection against human immunodeficiency virus type 1 (HIV-1), HIV-1-specific immune responses at mucosal sites in natural infection were compared. Total antibody concentrations and HIV-1-specific binding antibody responses in four distinct mucosal sites and serum were assessed in 41 HIV-infected and 19 HIV-seronegative women. HIV-1 gp160-specific IgG responses were detected in >99% of mucosal samples in infected subjects, with the highest titers in genital secretions. HIV-1-specific IgA was detected in the majority of endocervical secretions (94%) and nasal washes (95%) but less often in vaginal washes (51%) and parotid saliva (38%). There was no significant correlation between mucosal immune response and most clinical factors. Based on methodologic considerations, frequencies of detection, and HIV-1-specific responses, nasal washes and genital secretions may each provide important measures of HIV-1-specific mucosal immune responses in infected women. C1 HENRY M JACKSON FDN,ROCKVILLE,MD. SRA TECHNOL INC,GAITHERSBURG,MD. WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,WASHINGTON,DC 20307. RP Artenstein, AW (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,13 TAFT CT,SUITE 200,ROCKVILLE,MD 20850, USA. NR 28 TC 61 Z9 64 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD FEB PY 1997 VL 175 IS 2 BP 265 EP 271 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA WF063 UT WOS:A1997WF06300005 PM 9203646 ER PT J AU Lowell, GH Kaminski, RW VanCott, TC Slike, B Kersey, K Zawoznik, E LoomisPrice, L Smith, G Redfield, RR Amselem, S Birx, DL AF Lowell, GH Kaminski, RW VanCott, TC Slike, B Kersey, K Zawoznik, E LoomisPrice, L Smith, G Redfield, RR Amselem, S Birx, DL TI Proteosomes, emulsomes, and cholera toxin B improve nasal Immunogenicity of human immunodeficiency virus gp160 in mice: Induction of serum, intestinal, vaginal, and lung IgA and IgG SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 2nd National Conference on Human Retroviruses and Related Infections CY JAN 29-FEB 02, 1995 CL WASHINGTON, DC ID MUCOSAL IMMUNE-SYSTEM; INTRANASAL IMMUNIZATION; ANTIBODY-RESPONSES; PROTEIN ANTIGEN; LIPOPOLYSACCHARIDE VACCINES; INFLUENZA VACCINE; CELL-SURFACE; SUBUNIT; ENHANCEMENT; LIPOSOMES AB Intranasal immunization of mice with human immunodeficiency virus (HIV) rgp160 complexed to proteosomes improved anti-gp160 serum IgA and IgG titers, increased the number of gp160 peptides recognized, and stimulated anti-gp160 intestinal IgA compared with immunization with uncomplexed rgp160 in saline, These enhanced responses were especially evident when either a bioadhesive nanoemulsion (emulsomes) or cholera toxin B subunit (CTB) was added to the proteosome-rgp160 vaccine, Furthermore, anti-gp160 Ige and IgA in vaginal secretions and fecal extracts were induced after intranasal immunization with proteosome-rgp160 delivered either in saline or with emulsomes, Formulation of uncomplexed rgp160 with emulsomes or CTB also enhanced serum and selected mucosal IgA responses, Induction of serum, vaginal, bronchial, intestinal, and fecal IgA and IgG by intranasal proteosome-rgp160 vaccines delivered in saline or with emulsomes or CTB is encouraging for mucosal vaccine development to help control the spread of HIV transmission and AIDS. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,ROCKVILLE,MD. HENRY M JACKSON FDN,ROCKVILLE,MD. PHARMOS CORP,ALACHUA,FL. PHARMOS CORP,REHOVOT,ISRAEL. MICROGENESYS INC,MERIDEN,CT. RP Lowell, GH (reprint author), INTELLIVAX INC,6303 WESTERN RUN DR,BALTIMORE,MD 21215, USA. NR 64 TC 55 Z9 57 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD FEB PY 1997 VL 175 IS 2 BP 292 EP 301 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA WF063 UT WOS:A1997WF06300008 PM 9203649 ER PT J AU Lee, BW Cook, LP Schenck, PK WongNg, W Chiang, CK Brody, PS Bennett, KW AF Lee, BW Cook, LP Schenck, PK WongNg, W Chiang, CK Brody, PS Bennett, KW TI Processing and characterization of compositionally modified PbTiO3 thin films prepared by pulsed laser deposition SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID TITANATE CERAMICS; PRESSURE AB Modified lead titanate of 0.9PbTiO(3)-0.1Pb(Mg0.5W0.5)O-3 thin films have been deposited onto Pt-coated Si substrates by pulsed laser deposition. Films were crystallized in situ during deposition or by post-depositional heat treatment (post-annealing). Compositional and structural characterization showed that the phase formation and microstructure of the films were highly sensitive to deposition conditions. Perovskite single phase films were formed in situ at 650 degrees C, P-O2 = 40 Pa as well as by post-annealing amorphous films at 650 degrees C. In the post-annealing process, the amorphous as-deposited phase was crystallized to perovskite and/or pyrochlore, and the ratio of perovskite to pyrochlore was found to be influenced by the depositional P-O2. Depending on the deposition temperature, the grain structures of the crystallized films were columnar or equiaxed. A relatively homogeneous surface morphology was obtained by deposition at a lower pressure (P-O2 = 13 Pa). The in situ crystallized films showed variable crystallographic orientation. The more (111) oriented films had the lowest remanent polarizations and the highest coercive fields. A method for preparing randomly oriented films, via a two-step deposition process with intermediate annealing, is believed to give the most consistent results and the best ferroelectric properties at the present level of development. C1 NIST,GAITHERSBURG,MD 20899. USA,RES LAB,ADELPHI,MD 20783. NR 26 TC 10 Z9 10 U1 1 U2 1 PU MATERIALS RESEARCH SOCIETY PI WARRENDALE PA 506 KEYSTONE DR, WARRENDALE, PA 15086 SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD FEB PY 1997 VL 12 IS 2 BP 509 EP 517 DI 10.1557/JMR.1997.0073 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA WF468 UT WOS:A1997WF46800037 ER PT J AU Rice, WA AF Rice, WA TI Healthy service-in-Vietnam effect SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Letter RP Rice, WA (reprint author), USA,CTR HLTH PROMOT & PREVENT MED,ABERDEEN PROVING GROUND,MD 21010, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD FEB PY 1997 VL 39 IS 2 BP 101 EP 101 DI 10.1097/00043764-199702000-00003 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA WJ275 UT WOS:A1997WJ27500003 PM 9048314 ER PT J AU Bandrowsky, T Orr, FE Vorono, AA BerginSperry, M AF Bandrowsky, T Orr, FE Vorono, AA BerginSperry, M TI Desflurane for outpatient general anesthesia in third molar extraction cases SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article; Proceedings Paper CT 77th AAOMS Annual Meeting, Scientific Sessions and Exhibition CY SEP 12-17, 1995 CL TORONTO, CANADA SP AAOMS ID NITROUS-OXIDE; ISOFLURANE; RECOVERY; PROPOFOL; INDUCTION AB Purpose: The purpose of this study was to evaluate the use of desflurane, a new volatile anesthetic agent, in a standardized endotracheal anesthetic technique for the removal of third molars in ambulatory patients. Patients and Methods: Data were kept on 50 American Society of Anesthesiology (ASA) Class I and II patients undergoing oral endotracheal general anesthesia for removal of third molars, A standardized anesthetic technique was used on all patients, Induction was achieved with a bolus of propofol followed by neuromuscular paralysis with succinylcholine and then intubation. A 70% nitrous oxide, 30% oxygen, and desflurane mixture was titrated until there was no movement, and a local anesthetic was administered, The procedure was then completed in a standard fashion, The parameters measured included the length of surgery, the time from gas shutoff to extubation, the time from arrival in the postanesthesia care unit to achieving an Aldrete system score for discharge with an escort, the incidence of nausea and vomiting, and amnesia of the procedure. Results: This study showed that the use of desflurane as the primary anesthetic agent for procedures of less than 1 hour is a useful technique, The agent is expensive, but the decreased recovery time and minimal side effects may offset this expense. Conclusion: The desflurane anesthetic technique provides a satisfactory surgical environment in selected patients, It results in rapid postanesthesia recovery and discharge times, thus reducing costs. C1 USA HOSP,WURZBURG,GERMANY. MADIGAN ARMY MED CTR,TACOMA,WA 98431. RP Bandrowsky, T (reprint author), USA,DENTAC,DENT CLIN 2,FT SILL,OK 73503, USA. NR 20 TC 1 Z9 1 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD FEB PY 1997 VL 55 IS 2 BP 129 EP 132 DI 10.1016/S0278-2391(97)90226-3 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA WG082 UT WOS:A1997WG08200006 PM 9024348 ER PT J AU Manganaro, AM Will, MJ Ragno, JR Holton, JB AF Manganaro, AM Will, MJ Ragno, JR Holton, JB TI Red-blue lesion of the hard palate SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Editorial Material ID SALIVARY-GLAND TUMORS; MUCOEPIDERMOID CARCINOMA; ORIGIN C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. E TEXAS MED CTR,DEPT ORAL & MAXILLOFACIAL SURG,TYLER,TX. NR 17 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD FEB PY 1997 VL 55 IS 2 BP 159 EP 165 DI 10.1016/S0278-2391(97)90235-4 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA WG082 UT WOS:A1997WG08200015 PM 9024353 ER PT J AU Clarkson, E Cameron, S Osmon, P McGraw, C Smutok, M Stetts, D Underwood, F AF Clarkson, E Cameron, S Osmon, P McGraw, C Smutok, M Stetts, D Underwood, F TI Oxygen consumption, heart rate, and rating of perceived exertion in young adult women during backward walking at different speeds SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE backward walking; gait; oxygen consumption; heart rate; knee injury ID RESPONSES; COST; SEX AB Backward walking has gained popularity as an adjunct to treatment for patients undergoing rehabilitation for patellofemoral pain syndrome and anterior cruciate ligament injuries. Researchers have suggested that backward walking decreases the compressive forces at the patellofemoral joint while also preventing overstretching of the anterior cruciate ligament. Prior to this study, precise prescription of backward walking speeds for women was not possible. The purpose of this study was to determine the relationship between heart rate, oxygen consumption, and backward walking speeds. Twenty-five healthy, adult female volunteers participated in this study. Subjects were tested at speeds of 0.96, 1.20, 1.43, 1.67, and 1.91 m/sec. Subjects also performed a graded exercise stress test. Analysis revealed curvilinear relationships between oxygen consumption and speed as well as between heart rate and speed. With these results, clinicians may now prescribe specific speeds of backward walking for women to elicit a desired cardiopulmonary response. C1 KEESLER MED CTR,KEESLER AFB,MS. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. MONCRIEF ARMY COMMUNITY HOSP,FT JACKSON,SC. USA,ENVIRONM MED RES INST,OCCUPAT MED DIV,NATICK,MA 01760. BAYLOR UNIV,USA,GRAD PROGRAM PHYS THERAPY,AMEDD CTR,FT SAM HOUSTON,TX 78234. MCCS,HMT,FT SAM HOUSTON,TX 78234. RP Clarkson, E (reprint author), DEWITT ARMY COMMUNITY HOSP,FT BELVOIR,VA, USA. NR 17 TC 13 Z9 19 U1 0 U2 4 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD FEB PY 1997 VL 25 IS 2 BP 113 EP 118 PG 6 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA WD026 UT WOS:A1997WD02600004 PM 9007769 ER PT J AU Fitzpatrick, JC Jordan, BS Salman, N Williams, J Cioffi, WG Pruitt, BA AF Fitzpatrick, JC Jordan, BS Salman, N Williams, J Cioffi, WG Pruitt, BA TI The use of perfluorocarbon-associated gas exchange to improve ventilation and decrease mortality after inhalation injury in a neonatal swine model SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article; Proceedings Paper CT 27th Annual Meeting of the American-Pediatric-Surgical-Association CY MAY 19-22, 1996 CL SAN DIEGO, CA SP Amer Pediat Surg Assoc DE perfluorocarbon ventilation; PAGE; lung injury; barotrauma; volutrauma; inhalation injury ID PARTIAL LIQUID VENTILATION AB Patients with tracheobronchial disease frequently require mechanical ventilation during therapy and experience iatrogenic complications such as barotrauma and volutrauma. The purpose of this study was to determine whether perfluorocarbon-associated gas exchange (PAGE) results in lower ventilatory pressures and more efficient ventilation than that provided by conventional ventilation after tracheobronchial mucosal injury caused by smoke inhalation in neonatal piglets. Ten piglets were used for this prospective, randomized study. After administration of a severe smoke inhalation injury, the piglets were randomly assigned to either the perfluorocarbon or control groups. Group 1 served as the control population and received standard (time-cycled, volume-limited) mechanical ventilation. Ventilator settings were adjusted to maintain physiological pH and Po-2 at the lowest tidal volume, rate, and end-expiratory pressure possible throughout the study period. Group 2 was administered intratracheal perfluorocarbon as well as identical mechanical ventilation to attain the same physiological pH and Po-2. Oxygenation index, peak and mean airway pressures, and arterial blood gas levels were measured throughout the study period and subjected to statistical analysis. Histological comparison of airway and parenchymal tissues confirmed identical patterns of smoke injury in both groups. Carbon monoxide levels were the same in both groups. There was significant barotrauma and volutrauma in the control group, but none in the PAGE group. All controls died from 13 to 17 hours after injury; one PAGE pig died at 23 hours with all others surviving past 24 hours (P=.0021). Peak, plateau, and mean airway pressures were all significantly higher (P <.05) past 12 hours after injury and continued to increase until death in the controls. Arterial blood gases showed significantly (P <.05) decreased pH, PO2, and elevated PCO2 levels in the control group past 12 hours after injury. The oxygenation index was significantly elevated (P <.05) in the control group past 12 hours after injury. PAGE shows potential for improving ventilation and survival immediately after severe smoke inhalation injury and may have clinical applications in other nonhomogeneous lung injuries. Copyright (C) 1997 by W.B. Saunders Company. C1 USA,INST SURG RES,SAN ANTONIO,TX. NR 14 TC 11 Z9 12 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD FEB PY 1997 VL 32 IS 2 BP 192 EP 196 DI 10.1016/S0022-3468(97)90177-9 PG 5 WC Pediatrics; Surgery SC Pediatrics; Surgery GA WH207 UT WOS:A1997WH20700009 PM 9044120 ER EF