FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU LaKind, JS
Berlin, CM
Sjodin, A
Turner, W
Wang, RY
Needham, LL
Paul, IM
Stokes, JL
Naiman, DQ
Patterson, DG
AF LaKind, Judy S.
Berlin, Cheston M., Jr.
Sjodin, Andreas
Turner, Wayman
Wang, Richard Y.
Needham, Larry L.
Paul, Ian M.
Stokes, Jennifer L.
Naiman, Daniel Q.
Patterson, Donald G., Jr.
TI Do Human Milk Concentrations of Persistent Organic Chemicals Really
Decline During Lactation? Chemical Concentrations During Lactation and
Milk/Serum Partitioning
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE blood; breast milk; depuration; dioxins; elimination kinetics; infant
exposure; partitioning; PBDEs; PCBs; pesticides
ID POLYBROMINATED DIPHENYL ETHERS; HIGH-THROUGHPUT EXTRACTION; BREAST-MILK;
POLYCHLORINATED-BIPHENYLS; ADIPOSE-TISSUE; HUMAN-SERUM; CLEANUP METHOD;
CORD SERUM; BLOOD; DIOXINS
AB BACKGROUND: Conventional wisdom regarding exposures to persistent organic chemicals via breast-feeding assumes that concentrations decline over the course of lactation and that the mother's body burden reflects her cumulative lifetime exposure. Two important implications stemming from these lines of thought are, first, that assessments of early childhood exposures should incorporate decreasing breast milk concentrations over lactation; and, second, that there is little a breast-feeding mother can do to reduce her infant's exposures via breast-feeding because of the cumulative nature of these chemicals.
OBJECTIVES: We examined rates of elimination and milk/serum partition coefficients for several groups of persistent organic chemicals.
METHODS: We collected simultaneous milk and blood samples of 10 women at two times postpartum and additional milk samples without matching blood samples.
RESULTS: Contrary to earlier research, we found that lipid-adjusted concentrations of polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and furans, and organochlorine pesticides in serum and milk do not consistently decrease during lactation and can increase for some women. Published research has also suggested an approximate 1: 1 milk/serum relationship (lipid adjusted) on a population basis for 2,3,7,8-tetrachlorodibenzo-p-dioxin; however, our results suggest a more complex relationship for persistent, lipophilic chemicals with the milk/serum relationship dependent on chemical class.
CONCLUSIONS: Decreases in concentration of lipophilic chemicals on a lipid-adjusted basis during lactation should no longer be assumed. Thus, the concept of pumping and discarding early milk as means of reducing infant exposure is not supported. The hypothesis that persistent lipophilic chemicals, on a lipid-adjusted basis, have consistent concentrations across matrices is likely too simplistic.
C1 [LaKind, Judy S.] LaKind Associates LLC, Catonsville, MD 21228 USA.
[LaKind, Judy S.; Berlin, Cheston M., Jr.; Paul, Ian M.; Stokes, Jennifer L.] Penn State Coll Med, Milton S Hershey Med Ctr, Dept Pediat, Hershey, PA USA.
[LaKind, Judy S.] Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA.
[Sjodin, Andreas; Turner, Wayman; Wang, Richard Y.; Needham, Larry L.; Patterson, Donald G., Jr.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Naiman, Daniel Q.] Johns Hopkins Univ, Dept Appl Math & Stat, Baltimore, MD USA.
[Patterson, Donald G., Jr.] EnviroSolut Consulting Inc, Jasper, GA USA.
RP LaKind, JS (reprint author), LaKind Associates LLC, 106 Oakdale Ave, Catonsville, MD 21228 USA.
EM lakindassoc@comcast.net
RI Naiman, Daniel/A-3304-2010; Needham, Larry/E-4930-2011; Sjodin,
Andreas/F-2464-2010;
OI Naiman, Daniel/0000-0001-6504-9081; Paul, Ian/0000-0002-6344-8609
FU Research Foundation for Health and Environmental Effects (RFHEE),
Arlington, VA
FX Partial support for this research was provided by the Research
Foundation for Health and Environmental Effects (RFHEE), Arlington, VA.
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PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD OCT
PY 2009
VL 117
IS 10
BP 1625
EP 1631
DI 10.1289/ehp.0900876
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 503JI
UT WOS:000270529800041
PM 20019916
ER
PT J
AU Blount, BC
Rich, DQ
Valentin-Blasini, L
Lashley, S
Ananth, CV
Murphy, E
Smulian, JC
Spain, BJ
Barr, DB
Ledoux, T
Hore, P
Robson, M
AF Blount, Benjamin C.
Rich, David Q.
Valentin-Blasini, Liza
Lashley, Susan
Ananth, Cande V.
Murphy, Eileen
Smulian, John C.
Spain, Betty J.
Barr, Dana B.
Ledoux, Thomas
Hore, Paromita
Robson, Mark
TI Perinatal Exposure to Perchlorate, Thiocyanate, and Nitrate in New
Jersey Mothers and Newborns
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID TANDEM MASS-SPECTROMETRY; NUTRITION EXAMINATION SURVEY; SODIUM-IODIDE
SYMPORTER; AMNIOTIC-FLUID; UNITED-STATES; ION CHROMATOGRAPHY;
RADIOACTIVE IODIDE; ACTIVE-TRANSPORT; THYROID-FUNCTION; NATIONAL-HEALTH
AB Perchlorate is a commonly occurring environmental toxicant that maybe transported across the placental barrier by the sodium-iodide symporter (NIS), possibly resulting in both increased perchlorate exposure and decreased iodide uptake by the fetus. Therefore, we measured levels of three physiologically relevant NIS-inhibitors (perchlorate, nitrate, and thiocyanate) and iodide in maternal and fetal fluids collected during cesarean-section surgeries an 150 U.S. women. Geometric means of perchlorate, thiocyanate, and nitrate levels in maternal urine (2,90, 947, and 47900 mu g/L, respectively) were similar to previously published results, while urinary iodide levels (1420 mu g/L) were significantly higher (p < 0.0001), likely because of prevalent prenatal vitamin use in the study population (74%). Thiocyanate levels were higher in the maternal serum, cord serum, and amniotic fluid of smokers compared to women with environmental tobacco smoke exposure and nonsmokers (p-values of 0.0006, 0.0011, and 0.0026, respectively). Perchlorate was detected in most samples: urine (100%), maternal serum (94%), cord serum (67%), and amniotic fluid (97%). Maternal urinary perchlorate levels were positively correlated with perchlorate levels in amniotic fluid (r = 0.57), indicating that maternal urine perchlorate is an effective biomarker of fetal perchlorate exposure. Maternal serum perchlorate was generally higher than cord serum perchlorate (median ratio 2.41 for paired samples), and maternal urine perchlorate was always higher than fetal amniotic fluid perchlorate levels (mean ratio 22:1); conversely, iodide levels were typically higher in fetal fluids compared to maternal fluids. We found no evidence of either disproportionate perchlorate accumulation or lack of iodide in the fetal compartment In this panel of healthy infants, we found no association between cord blood levels of these anions and newborn weight length, and head circumference.
C1 [Blount, Benjamin C.; Valentin-Blasini, Liza; Spain, Betty J.; Barr, Dana B.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA 30333 USA.
[Rich, David Q.; Lashley, Susan; Smulian, John C.; Robson, Mark] UMDNJ, Sch Publ Hlth, Dept Epidemiol, Piscataway, NJ USA.
[Rich, David Q.; Hore, Paromita; Robson, Mark] UMDNJ, Robert Wood Johnson Med Sch, Environm & Occupat Hlth Sci Inst, Piscataway, NJ USA.
[Ananth, Cande V.] UMDNJ, Robert Wood Johnson Med Sch, Div Epidemiol & Biostat, Dept Obstet Gynecol & Reprod Sci, New Brunswick, NJ USA.
[Murphy, Eileen; Ledoux, Thomas] New Jersey Dept Environm Protect, Trenton, NJ USA.
[Smulian, John C.] Lehigh Valley Hlth Network, Div Maternal Fetal Med, Dept Obstet & Gynecol, Allentown, PA USA.
[Hore, Paromita] Rutgers State Univ, Dept Entomol, Sch Environm & Biol Sci, Piscataway, NJ USA.
RP Blount, BC (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA 30333 USA.
EM BBlount@cdc.gov
RI Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013
FU NIEHS [T32ES007148, P30ES005022]; NJDEP [SR04-058]
FX We thank Janice Menuel, John Morrow,and Marian Lake for technical
support. This work was supported by NIEHS Grant T32ES007148 (MR), NIEHS
Grant P30ES005022 (MR), and NJDEP Grant SR04-058 (MR). The findings and
conclusions in this report are those of the authors and do not
necessarily represent the views of the Centers for Disease Control and
Prevention or the New Jersey Department of Environmental Protection.
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD OCT 1
PY 2009
VL 43
IS 19
BP 7543
EP 7549
DI 10.1021/es9008486
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 498JT
UT WOS:000270136500062
PM 19848174
ER
PT J
AU Parko, K
Thurman, DJ
AF Parko, Karen
Thurman, David J.
TI Prevalence of epilepsy and seizures in the Navajo Nation 1998-2002
SO EPILEPSIA
LA English
DT Article
DE Epidemiology; Health disparities; Native American; Global health
AB P>Purpose:
To determine the prevalence of epilepsy and seizures in the Navajo.
Methods:
We studied 226,496 Navajo residing in the Navajo Reservation who had at least one medical encounter between October 1, 1998 and September 30, 2002. We ascertained and confirmed cases in two phases. First, we identified patients with International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes signifying epilepsy or seizures using Indian Health Service (IHS) administrative data. Second, we reviewed medical charts of a geographic subpopulation of identified patients to confirm diagnoses and assess the positive predictive value of the ICD-9-CM codes in identifying patients with active epilepsy.
Results:
Two percent of Navajo receiving IHS care were found to have an ICD-9-CM code consistent with epilepsy or seizures. Based on confirmed cases, the crude prevalence for the occurrence of any seizure (including febrile seizures and recurrent seizures that may have been provoked) in the geographic subpopulation was 13.5 per 1,000 and the crude prevalence of active epilepsy was 9.2 per 1,000. Prevalence was higher among males, children under 5 years of age, and older adults.
Discussion:
The estimated prevalence of active epilepsy in the Navajo Nation is above the upper limit of the range of reported estimates from other comparable studies of U.S. communities.
C1 [Parko, Karen] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA.
[Parko, Karen] San Francisco VA Med Ctr, San Francisco, CA USA.
[Thurman, David J.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Epilepsy Program, Atlanta, GA USA.
RP Parko, K (reprint author), 4150 Clement St 127, San Francisco, CA 94121 USA.
EM Karen.Parko@ucsf.edu
OI Thurman, David/0000-0002-0533-7062
FU CDC National Center for Chronic Disease Prevention and Health Promotion;
Indian Health Service Information Technology; Shiprock Service Unit
Health Board; Richard Champany DDS; CEO; Northern Navajo Medical Center;
National IHS IRB; Navajo Nation Human Research Review Board
FX The authors thank the following for their direct assistance: Indian
Health Service Information Technology Support Center; Anne Butman,
management analyst, DataCom Sciences; Yolinda Cadman; Dr. Nathanial
Cobb; Navajo Area medical records department; Northern Navajo Medical
Center in Shiprock: Gary Russell-King, in Kayenta: Lorraine Dohi, in
Crownpoint: Cynthia Begaye; Clinical pharmacists in the NNMC seizure
clinic: Tom Duran, Lauren Dolence, Melissa Stahlecker, Dr. David
Labiner, Karla Lindquist, Peter Taylor, and Elena Cherkasova. This work
could not have been undertaken without the support from: Duane H. Yazzie
and the Shiprock Chapter House; Manuel Morgan and the Shiprock Service
Unit Health Board; Richard Champany DDS, CEO, Northern Navajo Medical
Center; Phillip Smith, MD, MPH and the National IHS IRB; and Beverly
Pigman and the Navajo Nation Human Research Review Board.
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PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD OCT
PY 2009
VL 50
IS 10
BP 2180
EP 2185
DI 10.1111/j.1528-1167.2009.02140.x
PG 6
WC Clinical Neurology
SC Neurosciences & Neurology
GA 498GW
UT WOS:000270126300002
PM 19490040
ER
PT J
AU Burneo, JG
Jette, N
Theodore, W
Begley, C
Parko, K
Thurman, DJ
Wiebe, S
AF Burneo, Jorge G.
Jette, Nathalie
Theodore, William
Begley, Charles
Parko, Karen
Thurman, David J.
Wiebe, Samuel
CA Task Force Disparties Epilepsy
N Amer Commission Int League
TI Disparities in epilepsy: Report of a systematic review by the North
American Commission of the International League Against Epilepsy
SO EPILEPSIA
LA English
DT Editorial Material
DE Epilepsy; Disparity; North America
ID TEMPORAL-LOBE EPILEPSY; PUBLIC ATTITUDES; SOCIAL-SKILLS; SELF-EFFICACY;
UNITED-STATES; CHILDREN; HEALTH; SEIZURES; RACE/ETHNICITY; PREVALENCE
AB P>Purpose:
We undertook a systematic review of the evidence on disparities in epilepsy with a focus on North American data (Canada, United States, and the English-speaking Caribbean).
Methods:
We identified and evaluated: access to and outcomes following medical and surgical treatment, disability, incidence and prevalence, and knowledge and attitudes. An exhaustive search (1965-2007) was done, including: (1) disparities by socioeconomic status (SES), race/ethnicity, age, or education of subgroups of the epilepsy population; or (2) disparities between people with epilepsy (PWE) and healthy people or with other chronic illnesses.
Results:
From 1,455 citations, 278 eligible abstracts were identified and 44 articles were reviewed. Comparative research data were scarce in all areas. PWE have been shown to have lower education and employment status; among PWE, differences in access to surgery have been shown by racial/ethnic groups. Aboriginals, women, and children have been shown to differ in use of health resources. Poor compliance has been shown to be associated with lower SES, insufficient insurance, poor relationship with treating clinicians, and not having regular responsibilities.
Discussion:
Comprehensive, comparative research on all aspects of disparities in epilepsy is needed to understand the causes of disparities and the development of any policies aimed at addressing health disparities and minimizing their impact.
C1 [Burneo, Jorge G.] Univ Western Ontario, Epilepsy Programme, London, ON N6A 5A5, Canada.
[Jette, Nathalie; Wiebe, Samuel] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada.
[Theodore, William] NIH, Epilepsy Sect, Bethesda, MD 20892 USA.
[Begley, Charles] Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Houston, TX USA.
[Parko, Karen] Univ Calif San Francisco, US Publ Hlth Serv, San Francisco, CA 94143 USA.
[Thurman, David J.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Burneo, JG (reprint author), Univ Western Ontario, Epilepsy Programme, 339 Windermere Rd, London, ON N6A 5A5, Canada.
EM jburneo2@uwo.ca
RI shengkun, yu/B-8440-2012
FU Intramural NIH HHS [Z01 NS002236-32]
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U2 3
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD OCT
PY 2009
VL 50
IS 10
BP 2285
EP 2295
DI 10.1111/j.1528-1167.2009.02282.x
PG 11
WC Clinical Neurology
SC Neurosciences & Neurology
GA 498GW
UT WOS:000270126300014
PM 19732134
ER
PT J
AU Benn, EKT
Hauser, WA
Shih, T
Leary, L
Bagiella, E
Dayan, P
Green, R
Andrews, H
Thurman, DJ
Hesdorffer, DC
AF Benn, Emma K. T.
Hauser, W. Allen
Shih, Tina
Leary, Linda
Bagiella, Emilia
Dayan, Peter
Green, Robert
Andrews, Howard
Thurman, David J.
Hesdorffer, Dale C.
TI Underlying cause of death in incident unprovoked seizures in the urban
community of Northern Manhattan, New York City
SO EPILEPSIA
LA English
DT Article
DE Epilepsy; Epidemiology; Mortality
ID SHORT-TERM MORTALITY; EPILEPSY; COHORT
AB P>We determined underlying cause-specific mortality for incident unprovoked seizures from Northern Manhattan, New York City. We calculated the case fatality, proportionate mortality, and the underlying cause-specific standardized mortality ratios (SMRs), with U.S. death rates as the standard. Thirty-two deaths were observed between 2003 and 2007 among 209 participants. Case fatality was significantly lower for idiopathic/cryptogenic seizures versus symptomatic seizures. About 31.3% of the deaths were attributed to malignant neoplasms, 25.0% to diseases of the heart, 15.6% to influenza and pneumonia, 3.1% to cerebrovascular diseases, and 25.0% to other causes. Significant SMRs were observed for all causes (SMR = 1.6), influenza and pneumonia (SMR = 7.1), and malignant neoplasms (SMR = 2.9). Younger cases (< 65 years) had increased SMRs for all causes, malignant neoplasms, and other causes. Older cases (>= 65 years) had increased SMRs for influenza and pneumonia. Underlying cause of death paralleled the underlying cause of seizure in patients with symptomatic etiologies.
C1 [Benn, Emma K. T.; Hauser, W. Allen; Hesdorffer, Dale C.] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10032 USA.
[Hauser, W. Allen; Hesdorffer, Dale C.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA.
[Hauser, W. Allen] Columbia Univ, Dept Neurol, New York, NY 10032 USA.
[Shih, Tina] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA.
[Leary, Linda] Columbia Univ, Dept Neurol & Pediat, New York, NY 10032 USA.
[Bagiella, Emilia; Andrews, Howard] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USA.
[Dayan, Peter] Columbia Univ, Coll Phys & Surg, Dept Pediat, Morgan Stanley Childrens Hosp New York Presbyteri, New York, NY 10032 USA.
[Green, Robert] Columbia Univ, Coll Phys & Surg, Dept Emergency Med, New York, NY 10032 USA.
[Thurman, David J.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
RP Hesdorffer, DC (reprint author), Columbia Univ, Gertrude H Sergievsky Ctr, P&S Unit 16,630 W 168th St, New York, NY 10032 USA.
EM dch5@columbia.edu
FU Centers for Disease Control and Prevention [MM-0322]; Biostatistics
Enrichment Summer Training (BEST); Mailman School of Public Health
FX This work was supported by a grant from the Centers for Disease Control
and Prevention (MM-0322). The authors would like to thank the study
participants, as well as Mr. Julio Pina who worked on the study as a
summer fellow of the Biostatistics Enrichment Summer Training (BEST)
Diversity Program at the Mailman School of Public Health.We confirm that
we have read the Journal's position on issues involved in ethical
publication and affirm that this report is consistent with those
guidelines.
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PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0013-9580
J9 EPILEPSIA
JI Epilepsia
PD OCT
PY 2009
VL 50
IS 10
BP 2296
EP 2300
DI 10.1111/j.1528-1167.2009.02133.x
PG 5
WC Clinical Neurology
SC Neurosciences & Neurology
GA 498GW
UT WOS:000270126300015
PM 19490054
ER
PT J
AU Santos, R
Pratt, M
Ribeiro, JC
Santos, MP
Carvalho, J
Mota, J
AF Santos, R.
Pratt, M.
Ribeiro, J. C.
Santos, M. P.
Carvalho, J.
Mota, J.
TI Walking and body mass index in a portuguese sample of adults: a
multilevel analysis
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE walking; physical activity; obesity
ID PHYSICAL-ACTIVITY; METAANALYSIS; ASSOCIATION; OVERWEIGHT; INTENSITY;
OBESITY; HEALTH; WOMEN
AB Physical inactivity is an important risk factor for many chronic diseases. The purpose of this study was to investigate the cross-sectional associations between walking and body mass index (BMI). This study comprised 9991 adults (5723 women), aged 37.8 +/- 9.5 years, from the 2004 Azorean Physical Activity and Health Study. Walking was assessed with the International Physical Activity Questionnaire, and expressed as minutes per week. BMI was calculated from self-reported weight and height. A series of multilevel linear regression models were fitted to assess regression coefficients and s.e. predicting BMI. Results show that, in both genders, and after adjustments for potential confounders, walking was not a significant predictor of BMI. Therefore, our analysis does not extend the findings of earlier studies as it shows no significant associations between walking and BMI, after adjustments for potential confounders. Nevertheless, among Azoreans walking should be encouraged, as walking has other health benefits, beyond controlling obesity. European Journal of Clinical Nutrition (2009) 63, 1260-1262; doi:10.1038/ejcn.2009.47; published online 24 June 2009
C1 [Santos, R.; Ribeiro, J. C.; Santos, M. P.; Carvalho, J.; Mota, J.] Univ Porto, Res Ctr Phys Act Hlth & Leisure, Fac Sport, P-4200450 Oporto, Portugal.
[Pratt, M.] WHO Collaborating Ctr, Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA.
RP Santos, R (reprint author), Univ Porto, Res Ctr Phys Act Hlth & Leisure, Fac Sport, Rua Dr Placido Costa 91, P-4200450 Oporto, Portugal.
EM rutemarinasantos@hotmail.com
RI mota, jorge/B-2980-2013; Ribeiro, Jose/L-7487-2013; Carvalho,
Joana/L-7948-2013; Santos, Rute/A-6401-2012; Santos, Maria
Paula/L-7533-2013
OI mota, jorge/0000-0001-7571-9181; Ribeiro, Jose/0000-0001-6628-4606;
Carvalho, Joana/0000-0001-6500-7543; Santos, Rute/0000-0002-7604-5753;
Santos, Maria Paula/0000-0002-2182-9841
FU Azorean Government Department of Sports; Portuguese Foundation for
Science and Technology [PIHM/ESP/49737/03]; [FCT: BD/22587/2005]
FX This study was sponsored by the Azorean Government Department of Sports
and by the Portuguese Foundation for Science and Technology
(PIHM/ESP/49737/03). RS is supported by FCT: BD/22587/2005.
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PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD OCT
PY 2009
VL 63
IS 10
BP 1260
EP 1262
DI 10.1038/ejcn.2009.47
PG 3
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 503DZ
UT WOS:000270514100014
PM 19550431
ER
PT J
AU Martellini, JA
Cole, AL
Venkataraman, N
Quinn, GA
Svoboda, P
Gangrade, BK
Pohl, J
Sorensen, OE
Cole, AM
AF Martellini, Julie A.
Cole, Amy L.
Venkataraman, Nitya
Quinn, Gerry A.
Svoboda, Pavel
Gangrade, Bhushan K.
Pohl, Jan
Sorensen, Ole E.
Cole, Alexander M.
TI Cationic polypeptides contribute to the anti-HIV-1 activity of human
seminal plasma
SO FASEB JOURNAL
LA English
DT Article
DE antigens; epitopes; AIDS; reproductive immunology; viral; antimicrobial
ID IMMUNODEFICIENCY-VIRUS TYPE-1; POLYACRYLAMIDE-GEL ELECTROPHORESIS;
PROSTATE-SPECIFIC ANTIGEN; SPERM MOTILITY INHIBITOR; ANTIMICROBIAL
PEPTIDES; SEMENOGELIN-I; ANTIBACTERIAL ACTIVITY; ANTIVIRAL ACTIVITY;
PROTEIN; LACTOFERRIN
AB Mucosal surfaces of the reproductive tract as well as their secretions have important roles in preventing sexual transmission of HIV-1. In the current study, the majority of the intrinsic anti-HIV-1 activity of human seminal plasma (SP) was determined to reside in the cationic polypeptide fraction. Antiviral assays utilizing luciferase reporter cells and lymphocytic cells revealed the ability of whole SP to prevent HIV-1 infection, even when SP was diluted 3200-fold. Subsequent fractionation by continuous flow acid-urea (AU)-PAGE and antiviral testing revealed that cationic polypeptides within SP were responsible for the majority of anti-HIV-1 activity. A proteomic approach was utilized to resolve and identify 52 individual cationic polypeptides that contribute to the aggregate anti-HIV-1 activity of SP. One peptide fragment of semenogelin I, termed SG-1, was purified from SP by a multistep chromatographic approach, protein sequenced, and determined to exhibit anti-HIV-1 activity against HIV-1. Anti-HIV-1 activity was transient, as whole SP incubated for prolonged time intervals exhibited a proportional decrease in anti-HIV-1 activity that was directly attributed to the degradation of semenogelin I peptides. Collectively, these results indicate that the cationic polypeptide fraction of SP is active against HIV-1, and that semenogelin-derived peptides contribute to the intrinsic anti-HIV-1 activity of SP.-Martellini, J. A., Cole, A. C., Venkataraman, N., Quinn, G. A., Svoboda, P., Gangrade, B. K., Pohl, J., Sorensen, O. E., Cole, A. M. Cationic polypeptides contribute to the anti-HIV-1 activity of human seminal plasma. FASEB J. 23, 3609-3618 (2009). www.fasebj.org
C1 [Martellini, Julie A.; Cole, Amy L.; Venkataraman, Nitya; Quinn, Gerry A.; Cole, Alexander M.] Univ Cent Florida, Burnett Sch Biomed Sci, Biomol Sci Ctr, Dept Mol Biol & Microbiol, Orlando, FL 32816 USA.
[Svoboda, Pavel; Pohl, Jan] Ctr Dis Control & Prevent, Div Safety Res, Biotechnol Core Facil Branch, Atlanta, GA USA.
[Gangrade, Bhushan K.] Ctr Reprod Med, Orlando, FL USA.
[Sorensen, Ole E.] Lund Univ, Dept Clin Sci, Div Infect Med, Lund, Sweden.
RP Cole, AM (reprint author), 4000 Cent Florida Blvd,Bldg 20,Rm 236, Orlando, FL 32816 USA.
EM ole_e.sorensen@med.lu.se; acole@mail.ucf.edu
OI Sorensen, Ole E./0000-0001-8681-6921
FU NIAID NIH HHS [R01 AI052017-08, R01 AI052017, R01 AI052017-06, R01
AI052017-07, R01 AI052017-09, R01 AI052017-10]
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PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD OCT
PY 2009
VL 23
IS 10
BP 3609
EP 3618
DI 10.1096/fj.09-131961
PG 10
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 501BQ
UT WOS:000270354300037
PM 19487309
ER
PT J
AU Khoury, MJ
Rich, EC
Randhawa, G
Teutsch, SM
Niederhuber, J
AF Khoury, Muin J.
Rich, Eugene C.
Randhawa, Gurvaneet
Teutsch, Steven M.
Niederhuber, John
TI Comparative effectiveness research and genomic medicine: An evolving
partnership for 21st century medicine
SO GENETICS IN MEDICINE
LA English
DT Editorial Material
DE genomics; medicine; comparative effectiveness; evidence-based medicine
ID EGAPP WORKING GROUP; PERSONALIZED MEDICINE; WARFARIN; POLICY;
RECOMMENDATIONS; ANTICOAGULATION; PREDICTION; GENETICS; CANCER; HEALTH
AB The American Recovery and Reinvestment Act has provided resources for comparative effectiveness research that will lead to evidence-based decisions about health and health care choices. Some have voiced concerns that evidence-based comparative effectiveness research principles are only relevant to "average" patients and not as much to individuals with unique combinations of genes, exposures and disease outcomes, intrinsic to genomic medicine. In this commentary, we argue that comparative effectiveness research and genomic medicine not only can and should coexist but also they will increasingly benefit front each other. The promise and success of genomic medicine will depend on rigorous comparative effectiveness research to compare outcomes for genome-based applications in practice to traditional non-genome-based approaches. In addition, the success of comparative effectiveness research will depend on developing new methods and clinical research infrastructures to integrate genome-based personalized perspectives into point of care decisions by patients and providers. There is a need to heal the apparent schism between genomic medicine and comparative effectiveness research to enhance knowledge-driven practice of medicine in the 21st century. Genet Aled 2009:11(10):707-711.
C1 [Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA.
[Khoury, Muin J.; Niederhuber, John] NCI, Bethesda, MD 20892 USA.
[Rich, Eugene C.] Assoc Amer Med Coll, Washington, DC USA.
[Randhawa, Gurvaneet] Agcy Healthcare Res & Qual, Rockville, MD USA.
[Teutsch, Steven M.] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA.
RP Khoury, MJ (reprint author), Ctr Dis Control & Prevent, Off Publ Hlth Genom, 1600 Clifton Rd, Atlanta, GA 30333 USA.
EM mkhoury@cdc.gov
NR 40
TC 29
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U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1098-3600
J9 GENET MED
JI Genet. Med.
PD OCT
PY 2009
VL 11
IS 10
BP 707
EP 711
DI 10.1097/GIM.0b013e3181b99b90
PG 5
WC Genetics & Heredity
SC Genetics & Heredity
GA 515EK
UT WOS:000271449800003
PM 19752739
ER
PT J
AU Goins, R
Spencer, S
McGuire, LC
Henderson, JA
Wen, Y
Goldberg, J
AF Goins, R.
Spencer, S.
McGuire, L. C.
Henderson, J. A.
Wen, Y.
Goldberg, J.
TI ADULT CAREGIVING AMONG AMERICAN INDIANS: THE ROLE OF CULTURAL INDICATORS
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Goins, R.] W Virginia Univ, Hlth Sci Ctr, Ctr Aging, Dept Community Med, Morgantown, WV 26506 USA.
[Spencer, S.] Univ S Carolina, Dept Hlth Promot Educ & Behav, Columbia, SC 29208 USA.
[McGuire, L. C.] Ctr Dis Control & Prevent, Healthy Aging Program, Atlanta, GA USA.
[Henderson, J. A.; Wen, Y.] Black Hills Ctr Amer Indian Hlth, Rapid City, SD USA.
[Goldberg, J.] Univ Washington, Seattle, WA 98195 USA.
[Goldberg, J.] Epidemiol Res & Informat Ctr, Seattle Dept Vet Affairs, Seattle, WA USA.
NR 0
TC 0
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U1 0
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PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 109
EP 109
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UI
UT WOS:000271793900512
ER
PT J
AU Wu, B
Wei, L
Liang, J
AF Wu, B.
Wei, L.
Liang, J.
TI GENDER VARIATIONS IN THE ONSET OF FUNCTIONAL LIMITATIONS: DO BLACK,
HISPANIC, AND WHITE AMERICANS DIFFER?
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Wu, B.] Univ N Carolina, Greensboro, NC 27412 USA.
[Liang, J.] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
[Wei, L.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
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U1 0
U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 111
EP 111
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UI
UT WOS:000271793900521
ER
PT J
AU Kruger, J
AF Kruger, J.
TI HEALTHY OLDER ADULTS IN HEALTHY COMMUNITY ENVIRONMENTS
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Kruger, J.] CDC, PAHB, Atlanta, GA 30333 USA.
NR 0
TC 0
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PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
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PD OCT
PY 2009
VL 49
SU 2
BP 135
EP 135
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UI
UT WOS:000271793900632
ER
PT J
AU Brown, M
McGuire, L
Toal, S
Burgio, L
AF Brown, M.
McGuire, L.
Toal, S.
Burgio, L.
TI DEVELOPING AN ACTION GUIDE TO ASSIST WITH MOVING CAREGIVING
INTERVENTIONS INTO PRACTICE
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Brown, M.; McGuire, L.] CDC, Healthy Aging Program, Atlanta, GA 30333 USA.
[Burgio, L.] Univ Michigan, Ann Arbor, MI 48109 USA.
[Toal, S.] SB Toal, Atlanta, GA USA.
NR 0
TC 0
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U1 0
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PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 201
EP 201
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UI
UT WOS:000271793900951
ER
PT J
AU McGuire, L
Bouldin, E
Andresen, E
Anderson, L
AF McGuire, L.
Bouldin, E.
Andresen, E.
Anderson, L.
TI A SNAPSHOT OF THE HEALTH OF CAREGIVERS IN HAWAII, KANSAS, AND
WASHINGTON, BEHAVIORAL RISK FACTOR SURVEILLANCE SYSTEMS 2007
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [McGuire, L.; Anderson, L.] CDC, Atlanta, GA 30333 USA.
[Bouldin, E.; Andresen, E.] Univ Florida, Gainesville, FL USA.
NR 0
TC 0
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PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 224
EP 224
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100096
ER
PT J
AU Barnes, LL
Wilson, RS
Hebert, LE
Scherr, PA
Evans, DA
de Leon, CFM
AF Barnes, L. L.
Wilson, R. S.
Hebert, L. E.
Scherr, P. A.
Evans, D. A.
de Leon, C. F. Mendes
TI RACE, EDUCATION, AND HEALTH IN LATE LIFE
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Barnes, L. L.; Wilson, R. S.; Hebert, L. E.; Evans, D. A.; de Leon, C. F. Mendes] Rush Univ, Med Ctr, Chicago, IL 60612 USA.
[Scherr, P. A.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
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U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 231
EP 232
PG 2
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100129
ER
PT J
AU Li, J
Zhao, G
Pollack, L
Lee, J
Joseph, D
AF Li, J.
Zhao, G.
Pollack, L.
Lee, J.
Joseph, D.
TI THE USE OF PSA TEST AMONG MEN AGED 75 YEARS AND OLDER IN THE UNITED
STATES: FINDINGS FROM THE 2006 BEHAVIORAL RISK FACTOR SURVEILLANCE
SYSTEM DATA
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Li, J.; Zhao, G.; Pollack, L.; Lee, J.; Joseph, D.] CDC, Atlanta, GA 30333 USA.
NR 0
TC 0
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U1 0
U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 243
EP 243
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100183
ER
PT J
AU Dwyer, LL
Caffrey, C
Jones, A
Sengupta, M
Moss, A
Harris-Kojetin, L
AF Dwyer, L. L.
Caffrey, C.
Jones, A.
Sengupta, M.
Moss, A.
Harris-Kojetin, L.
TI NATIONAL HOME AND HOSPICE CARE SURVEY: PATIENT DATA
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Dwyer, L. L.; Caffrey, C.; Jones, A.; Sengupta, M.; Moss, A.; Harris-Kojetin, L.] CDC, Natl Ctr Hlth Stat, Div Hlth Care Stat, Hyattsville, MD USA.
NR 0
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PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 259
EP 259
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100258
ER
PT J
AU Cheng, YJ
de Rekeneire, N
Caspersen, C
AF Cheng, Y. J.
de Rekeneire, N.
Caspersen, C.
TI CHANGE IN RATE OF SEDENTARY LIFESTYLE AMONG US OLDER ADULTS WITH AND
WITHOUT DIABETES: 1997-2004
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Cheng, Y. J.; Caspersen, C.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[de Rekeneire, N.] Yale Univ, Sch Med, New Haven, CT USA.
RI Caspersen, Carl/B-2494-2009
NR 0
TC 1
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PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 294
EP 294
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100425
ER
PT J
AU Kruger, J
Loustalot, F
AF Kruger, J.
Loustalot, F.
TI PHYSICAL ACTIVITY GUIDELINES FOR OLDER AMERICANS
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Kruger, J.; Loustalot, F.] CDC, PAHB, Atlanta, GA 30333 USA.
NR 0
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U1 0
U2 1
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 294
EP 294
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100423
ER
PT J
AU Zhao, G
Ford, ES
Li, C
Balluz, LS
AF Zhao, G.
Ford, E. S.
Li, C.
Balluz, L. S.
TI ARE US OLDER ADULTS WITH DIAGNOSED DIABETES MEETING PHYSICAL ACTIVITY
RECOMMENDATIONS?
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Zhao, G.; Ford, E. S.; Li, C.; Balluz, L. S.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 294
EP 294
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100424
ER
PT J
AU Kirtland, K
Caspersen, C
Zack, M
AF Kirtland, K.
Caspersen, C.
Zack, M.
TI PROJECTING THE NEED FOR STATE-BASED PHYSICAL ACTIVITY PROGRAMS FOR OLDER
ADULTS WITH DIABETES
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Kirtland, K.] Northrop Grumman, Atlanta, GA USA.
[Kirtland, K.; Caspersen, C.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA.
[Zack, M.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA USA.
RI Caspersen, Carl/B-2494-2009
NR 0
TC 0
Z9 0
U1 0
U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 295
EP 295
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100426
ER
PT J
AU Magaziner, J
Anderson, L
AF Magaziner, J.
Anderson, L.
TI CREATIVE APPROACHES TO PREVENTION AND HEALTHY AGING
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Magaziner, J.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
[Anderson, L.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
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U1 0
U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 332
EP 332
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100610
ER
PT J
AU Sambhara, P
AF Sambhara, P.
TI MODULATING INNATE IMMUNITY IN OLDER ADULTS TO ENHANCE DISEASE RESISTANCE
AND VACCINE EFFICACY
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Sambhara, P.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA.
NR 0
TC 0
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U1 0
U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 346
EP 346
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100678
ER
PT J
AU McGuire, L
Strine, T
Anderson, L
AF McGuire, L.
Strine, T.
Anderson, L.
TI CHRONIC DISEASE AND HEALTHY LIFESTYLE AS A FUNCTION OF DEPRESSION
SYMPTOMS, 2003 BRFSS
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [McGuire, L.; Strine, T.; Anderson, L.] CDC, Atlanta, GA 30333 USA.
NR 0
TC 0
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U1 0
U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 351
EP 352
PG 2
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100704
ER
PT J
AU Dellinger, A
AF Dellinger, A.
TI PEARLS AND PERILS OF LONGITUDINAL DATASETS: PERSPECTIVES FROM AN
EPIDEMIOLOGIST
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Dellinger, A.] CDC, Injury Ctr, Atlanta, GA 30333 USA.
NR 0
TC 0
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U1 0
U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
SU 2
BP 362
EP 362
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100758
ER
PT J
AU Stevens, JA
AF Stevens, J. A.
TI BUILDING THE AGENDA: THE BURDEN AND IMPACT OF FALL INJURIES
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Stevens, J. A.] Ctr Dis Control, Atlanta, GA 30333 USA.
NR 0
TC 0
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U1 0
U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
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PD OCT
PY 2009
VL 49
SU 2
BP 381
EP 381
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UK
UT WOS:000271794100852
ER
PT J
AU Perkins, M
Adelman, R
Furlow, C
Sweatman, WM
Baird, J
AF Perkins, M.
Adelman, R.
Furlow, C.
Sweatman, W. M.
Baird, J.
TI FACTORS ASSOCIATED WITH TURNOVER IN ASSISTED LIVING: A MULTILEVEL
ANALYSIS
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Perkins, M.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Sweatman, W. M.; Baird, J.] Georgia State Univ, Atlanta, GA 30303 USA.
[Adelman, R.] SUNY Buffalo, Buffalo, NY 14260 USA.
[Furlow, C.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
BP 465
EP 465
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UL
UT WOS:000271794200284
ER
PT J
AU Day, K
Wu, B
Friedman, DB
McGuire, L
Laditka, SB
Laditka, JN
Hunter, R
Anderson, L
AF Day, K.
Wu, B.
Friedman, D. B.
McGuire, L.
Laditka, S. B.
Laditka, J. N.
Hunter, R.
Anderson, L.
TI PHYSICIAN BELIEFS AND PRACTICES FOR REDUCING RISKS OF COGNITIVE
IMPAIRMENT: A LARGE NATIONAL SURVEY
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Day, K.; McGuire, L.; Anderson, L.] Ctr Dis Control & Prevent, Healthy Aging Program, Atlanta, GA USA.
[Wu, B.] Univ N Carolina, Greensboro, NC 27412 USA.
[Friedman, D. B.] Univ S Carolina, Columbia, SC 29208 USA.
[Laditka, S. B.; Laditka, J. N.] Univ N Carolina, Charlotte, NC 28223 USA.
[Hunter, R.] Univ N Carolina, Chapel Hill, NC USA.
NR 0
TC 0
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PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
BP 481
EP 481
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UL
UT WOS:000271794200359
ER
PT J
AU McGuire, L
Brown, M
AF McGuire, L.
Brown, M.
TI THE NEED FOR TRANSLATING EVIDENCE-BASED INTERVENTIONS: WHAT DO THE DATA
TELL US ABOUT THE HEALTH AND WELL-BEING OF CAREGIVERS?
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [McGuire, L.; Brown, M.] CDC, Atlanta, GA 30333 USA.
NR 0
TC 0
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U1 2
U2 2
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
BP 484
EP 484
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UL
UT WOS:000271794200374
ER
PT J
AU McGuire, L
AF McGuire, L.
TI REACH OUT: THE BENEFIT OF ACTION GUIDES FOR TRANSLATING EVIDENCE-BASED
INTERVENTIONS FOR CAREGIVERS
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [McGuire, L.] CDC, Atlanta, GA 30333 USA.
NR 0
TC 0
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U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
BP 484
EP 484
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UL
UT WOS:000271794200373
ER
PT J
AU Toal, SB
AF Toal, S. B.
TI DEVELOPING AN ACTION GUIDE TO TRANSLATE A CAREGIVING INTERVENTION
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Toal, S. B.] CDC, Atlanta, GA 30333 USA.
NR 0
TC 0
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PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
BP 484
EP 485
PG 2
WC Gerontology
SC Geriatrics & Gerontology
GA 519UL
UT WOS:000271794200376
ER
PT J
AU de Leon, CFM
Cagney, KA
Rajan, K
Barnes, LL
Scherr, PA
Evans, DA
AF de Leon, C. F. Mendes
Cagney, K. A.
Rajan, K.
Barnes, L. L.
Scherr, P. A.
Evans, D. A.
TI NEIGHBORHOOD COHESION AND DISORDER IN RELATION TO CHANGE IN DISABILITY
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [de Leon, C. F. Mendes; Rajan, K.; Barnes, L. L.; Evans, D. A.] Rush Univ, Med Ctr, Chicago, IL 60612 USA.
[Cagney, K. A.] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA.
[Scherr, P. A.] Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
BP 501
EP 501
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UL
UT WOS:000271794200447
ER
PT J
AU Wadley, VG
Unverzagt, FW
McGuire, LC
Moy, CS
Kissela, B
McClure, LA
Crowe, M
Howard, VJ
AF Wadley, V. G.
Unverzagt, F. W.
McGuire, L. C.
Moy, C. S.
Kissela, B.
McClure, L. A.
Crowe, M.
Howard, V. J.
TI REGIONAL DISPARITIES IN INCIDENT COGNITIVE DECLINE: THE REGARDS STUDY
SO GERONTOLOGIST
LA English
DT Meeting Abstract
C1 [Wadley, V. G.; McClure, L. A.; Crowe, M.; Howard, V. J.] Univ Alabama, Birmingham, AL USA.
[Unverzagt, F. W.] Indiana Univ, Sch Med, Indianapolis, IN USA.
[McGuire, L. C.] Ctr Dis Control & Prevent, Healthy Aging Program, Atlanta, GA USA.
[Moy, C. S.] NINDS, NIH, Bethesda, MD 20892 USA.
[Kissela, B.] Univ Cincinnati, Cincinnati, OH USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD OCT
PY 2009
VL 49
BP 524
EP 524
PG 1
WC Gerontology
SC Geriatrics & Gerontology
GA 519UL
UT WOS:000271794200565
ER
PT J
AU Harvey, SM
Kraft, JM
West, SG
Taylor, AB
Pappas-DeLuca, KA
Beckman, LJ
AF Harvey, S. Marie
Kraft, Joan Marie
West, Stephen G.
Taylor, Aaron B.
Pappas-DeLuca, Katina A.
Beckman, Linda J.
TI Effects of a Health Behavior Change Model-Based HIV/STI Prevention
Intervention on Condom Use Among Heterosexual Couples: A Randomized
Trial
SO HEALTH EDUCATION & BEHAVIOR
LA English
DT Article
DE HIV prevention; STI prevention; couple-based intervention; health
behavior model
ID SEXUALLY-TRANSMITTED-DISEASES; HIV-PREVENTION; MULTIETHNIC
NEIGHBORHOODS; DECISION-MAKING; RISK BEHAVIOR; UNITED-STATES; WOMEN;
POWER; AIDS; DISPARITIES
AB This study examines an intervention for heterosexual couples to prevent human immunodeficiency virus/sexually transmitted infections. It also evaluates the effect of the intervention, which is based on current models of health behavior change, on intermediate outcomes (individual and relationship factors) and consistency of condom use. Eligible couples were administered a baseline interview and randomized to either a 3-session theory-based intervention or a 1-session standard of care comparison condition. Men and women completed 3-month interviews; only women completed 6-month interviews. No significant intervention effect on condom use was found among couples at 3 months (n = 212) or among women (n = 178) at 6 months. However, condom use increased significantly between baseline and 3 months and baseline and 6 months for participants in both treatment conditions. Intervention effects on condom use self-efficacy were found at 3 months and 6 months and on health-protective communication at 3 months. These findings provide valuable information for the design of future studies to help disentangle the effects of intervening with couples.
C1 [Harvey, S. Marie] Oregon State Univ, Dept Publ Hlth, Corvallis, OR 97331 USA.
[Kraft, Joan Marie; Pappas-DeLuca, Katina A.] US Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA.
[West, Stephen G.; Taylor, Aaron B.] Arizona State Univ, Dept Psychol, Tempe, AZ 85287 USA.
[Beckman, Linda J.] Alliant Univ, Alhambra, CA USA.
RP Harvey, SM (reprint author), Oregon State Univ, Dept Publ Hlth, Corvallis, OR 97331 USA.
EM marie.harvey@oregonstate.edu
NR 48
TC 17
Z9 17
U1 1
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1090-1981
J9 HEALTH EDUC BEHAV
JI Health Educ. Behav.
PD OCT
PY 2009
VL 36
IS 5
BP 878
EP 894
DI 10.1177/1090198108322821
PG 17
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 502JG
UT WOS:000270454300005
PM 18784350
ER
PT J
AU Livingston, S
Bruden, DL
Townshend-Bulson, LJ
Homan, CE
McMahon, BJ
Pawlotsky, JM
Chevaliez, S
Bruce, M
Rosen, HR
Gretch, DR
AF Livingston, Stephen
Bruden, Dana L.
Townshend-Bulson, Lisa J.
Homan, Chriss E.
McMahon, Brian J.
Pawlotsky, Jean-Michel
Chevaliez, Stephane
Bruce, Michael
Rosen, Hugo R.
Gretch, David R.
TI GENOTYPE 1 VERSUS GENOTYPES 2 AND 3, FEMALE GENDER AND YOUNGER AGE ARE
ASSOCIATED WITH RECOVERY FROM HEPATITIS C VIRUS INFECTION IN ALASKA
NATIVE AND AMERICAN INDIAN PERSONS
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases
CY OCT 30-NOV 03, 2009
CL Boston, MA
SP Amer Assoc Study Liver Dis
C1 [Livingston, Stephen; Townshend-Bulson, Lisa J.; Homan, Chriss E.; McMahon, Brian J.] Alaska Natve Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Anchorage, AK USA.
[Bruden, Dana L.; McMahon, Brian J.; Bruce, Michael] Ctr Dis Control & Prevent, Arctic Invest Program, Div Emerging Infect & Surveillance Serv, Natl Ctr Preparedness Detect & Control Infect Dis, Anchorage, AK USA.
[Pawlotsky, Jean-Michel; Chevaliez, Stephane] French Natl Reference Ctr Viral Hepatitis B C & D, Creteil, France.
[Pawlotsky, Jean-Michel; Chevaliez, Stephane] Univ Paris 12, Hop Henri Mondor, F-94010 Creteil, France.
[Rosen, Hugo R.] Univ Colorado, Sch Med, Dept Med, Div Gastroenterol & Hepatol, Denver, CO USA.
[Gretch, David R.] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98195 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2009
VL 50
IS 4
MA 81
BP 342A
EP 342A
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 502JV
UT WOS:000270456000082
ER
PT J
AU Golden-Mason, L
Palmer, BE
Kassam, N
Townshend-Bulson, LJ
Livingston, S
McMahon, BJ
Kuchroo, V
Gretch, DR
Rosen, HR
AF Golden-Mason, Lucy
Palmer, Brent E.
Kassam, Nasim
Townshend-Bulson, Lisa J.
Livingston, Stephen
McMahon, Brian J.
Kuchroo, Vijay
Gretch, David R.
Rosen, Hugo R.
TI NEGATIVE IMMUNE REGULATOR TIM-3 IS OVEREXPRESSED ON INTRAHEPATIC AND
PERIPHERAL T CELLS IN CHRONIC HCV INFECTION AND ITS BLOCKADE RESCUES
DYSFUNCTIONAL CD4+AND CD8+T CELLS
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases
CY OCT 30-NOV 03, 2009
CL Boston, MA
SP Amer Assoc Study Liver Dis
C1 [Golden-Mason, Lucy; Palmer, Brent E.; Rosen, Hugo R.] Univ Colorado HSC, Aurora, CO USA.
[Kassam, Nasim; Kuchroo, Vijay] Harvard Univ, Sch Med, Ctr Neurol Dis, Boston, MA USA.
[Townshend-Bulson, Lisa J.; Livingston, Stephen; McMahon, Brian J.] Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Anchorage, AK USA.
[McMahon, Brian J.] Ctr Dis Control & Prevent, Arctic Invest Program, Anchorage, AK USA.
[Gretch, David R.] Univ Washington, Div Lab Med, Seattle, WA 98195 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2009
VL 50
IS 4
MA 178
BP 387A
EP 387A
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 502JV
UT WOS:000270456000179
ER
PT J
AU Avery, JR
King, H
Reichert, PE
Yu, YY
Nickell, S
AF Avery, Jacqueline R.
King, Hope
Reichert, Phillip E.
Yu, Ying-Ying
Nickell, Steve
TI PREVENTING LIVER DISEASE BY VACCINATING HIGH-RISK ADULTS FOR HBV
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases
CY OCT 30-NOV 03, 2009
CL Boston, MA
SP Amer Assoc Study Liver Dis
C1 [Avery, Jacqueline R.; King, Hope] CDC, DVH, Atlanta, GA 30333 USA.
[Reichert, Phillip E.] Florida Dept Hlth, Hepatitis Prevent Program, Tallahassee, FL USA.
[Yu, Ying-Ying] Calif Dept Hlth, STD Control Branch, Richmond, CA USA.
[Nickell, Steve] Calif Dept Hlth, Imminizat Branch, Richmond, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2009
VL 50
IS 4
MA 743
BP 652A
EP 653A
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 502JV
UT WOS:000270456000742
ER
PT J
AU McMahon, BJ
Bulkow, L
Livingston, S
Homan, CE
Negus, S
Snowball, M
Chaves, SS
Hu, D
Bruce, M
AF McMahon, Brian J.
Bulkow, Lisa
Livingston, Stephen
Homan, Chriss E.
Negus, Susan
Snowball, Mary
Chaves, Sandra S.
Hu, Dale
Bruce, Michael
TI PREVALENCE OF HEPATITIS B "E" ANTIGEN NEGATIVE ACTIVE HEPATITIS IN
ALASKA NATIVE PERSONS WITH CHRONIC HEPATITIS B INFECTION: A PROSPECTIVE
7 YEAR FOLLOW-UP STUDY
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 60th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases
CY OCT 30-NOV 03, 2009
CL Boston, MA
SP Amer Assoc Study Liver Dis
C1 [McMahon, Brian J.; Livingston, Stephen; Homan, Chriss E.; Negus, Susan; Snowball, Mary] Alaska Native Tribal Hlth Consortium, Liver Dis & Hepatitis Program, Anchorage, AK USA.
[McMahon, Brian J.; Bulkow, Lisa; Bruce, Michael] Ctr Dis Control & Prevent, Arctic Invest Program, Natl Ctr Div Emerging Infect & Surveillance Serv, Natl Ctr Preparedness Detect & Control Infect Dis, Anchorage, AK USA.
[Chaves, Sandra S.; Hu, Dale] Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2009
VL 50
IS 4
MA 1441
BP 967A
EP 967A
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 502JV
UT WOS:000270456001437
ER
PT J
AU Lepus, CM
Gibson, TF
Gerber, SA
Kawikova, I
Szczepanik, M
Hossain, J
Ablamunits, V
Kirkiles-Smith, N
Herold, KC
Donis, RO
Bothwell, AL
Pober, JS
Harding, MJ
AF Lepus, Christin M.
Gibson, Thomas F.
Gerber, Scott A.
Kawikova, Ivana
Szczepanik, Marian
Hossain, Jaber
Ablamunits, Vitaly
Kirkiles-Smith, Nancy
Herold, Kevan C.
Donis, Ruben O.
Bothwell, Alfred L.
Pober, Jordan S.
Harding, Martha J.
TI Comparison of human fetal liver, umbilical cord blood, and adult blood
hematopoietic stem cell engraftment in NOD-scid/gamma c(-/-),
Balb/c-Rag1(-/-)gamma c(-/-), and C.B-17-scid/bg immunodeficient mice
SO HUMAN IMMUNOLOGY
LA English
DT Article
DE Hematopoietic stem cell; Mouse model; Human immune system development;
Delayed-type hypersensitivity; Isotype switching
ID SCID IL2R-GAMMA(NULL) MICE; RECEPTOR-GAMMA CHAIN; MOUSE MODEL; T-CELLS;
HUMAN-LYMPHOCYTES; RHEUMATOID-FACTOR; IMMUNE-SYSTEM; CD34(+) CELLS; HU
MOUSE; B-CELLS
AB Immunodeficient mice bearing components of a human immune system present a novel approach for studying human immune responses. We investigated the number, phenotype, developmental kinetics, and function of developing human immune cells following transfer of CD34(+) hematopoietic stem cell (HSC) preparations originating from second trimester human fetal liver (HFL), umbilical cord blood (UCB), or granulocyte colony-stimulating factor-mobilized adult blood (G-CSF-AB) delivered via intrahepatic injection into sublethally irradiated neonatal NOD-scid/gamma c(-/-), Balb/c-Rag1(-/-)gamma c(-/-), and C.B-17-scid/bg mice. HFL and UCB HSC provided the greatest number and breadth of developing cells. NOD-scid/gamma c(-/-) and Balb/c-Rag1(-/-)gamma c(-/-) harbored human B and dendritic cells as well as human platelets in peripheral blood, whereas NOD-scid/gamma c(-/-) mice harbored higher levels of human T cells. NOD-scid/gamma c(-/-) mice engrafted with HFL CD34(+) HSC demonstrated human immunological competence evidenced by white pulp expansion and increases in total human immunoglobulin following immunization with T-dependent antigens and delayed-type hypersensitivity-infiltrating leukocytes in response to antigenic challenge. In conclusion, we describe an encouraging base system for studying human hematopoietic lineage development and function utilizing human HFL or UCB HSC-engrafted NOD-scid/gamma c(-/-) mice that is well suited for future studies toward the development of a fully competent humanized mouse model. (C) 2009 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
C1 [Lepus, Christin M.; Harding, Martha J.] Yale Univ, Comparat Med Sect, Sch Med, New Haven, CT 06509 USA.
[Gibson, Thomas F.; Gerber, Scott A.; Kawikova, Ivana; Ablamunits, Vitaly; Kirkiles-Smith, Nancy; Herold, Kevan C.; Bothwell, Alfred L.; Pober, Jordan S.] Yale Univ, Dept Immunobiol, Sch Med, New Haven, CT 06509 USA.
[Szczepanik, Marian] Dept Human Dev Biol, Krakow, Poland.
[Szczepanik, Marian] Jagiellonian Univ, Coll Med, Krakow, Poland.
[Hossain, Jaber; Donis, Ruben O.] Ctr Dis Control, Influenza Div, Atlanta, GA 30333 USA.
[Pober, Jordan S.] Yale Univ, Dept Pathol, Sch Med, New Haven, CT 06509 USA.
[Pober, Jordan S.] Yale Univ, Dept Dermatol, Sch Med, New Haven, CT 06509 USA.
RP Harding, MJ (reprint author), Yale Univ, Comparat Med Sect, Sch Med, New Haven, CT 06509 USA.
EM martha.harding@yale.edu
FU NIH [P01-HL070295]
FX We thank Dr. Leonard Shultz, Jackson Laboratories, and Dr. Drew Pardoll,
Johns Hopkins University for the donations of breeding pairs of
NOD-scid/gamma-/- and Balb/c-Rag1 gamma-/- mice,
respectively; Drs. Li Wen and Sara Rockwell for the donations of control
NOD and Balb/c mice, respectively; Dr. Bradford Poulos of the Human
Fetal Tissue Repository, Albert Einstein College of Medicine, for human
fetal liver tissue; Dr. Diane Krause and Wendy Haskell at the Yale
Center of Excellence in Molecular Hematology (NIH No. DK0724429) for
G-CSF-AB-isolex cells: Labor and Birth Yale-New Haven Hospital staff and
Ann Marie Franco for UCB cells; Paul Bonjiorni for assistance with
irradiation; and Lisa Gras, Louise Benson and Michelle Benevento for
assistance with mice. Helpful discussions with Drs. Elizabeth Eynon,
Anthony Rongvaux, Tim Willinger, and Diane Krause are also gratefully
acknowledged. This study was supported by the Section of Comparative
Medicine and NIH Grant P01-HL070295. MJH is the recipient of a Research
Scholar Award from the American Gastroenterology Association.
NR 44
TC 58
Z9 59
U1 2
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0198-8859
J9 HUM IMMUNOL
JI Hum. Immunol.
PD OCT
PY 2009
VL 70
IS 10
BP 790
EP 802
DI 10.1016/j.humimm.2009.06.005
PG 13
WC Immunology
SC Immunology
GA 503YI
UT WOS:000270577900005
PM 19524633
ER
PT J
AU Hughes, MA
Burns, DL
Juris, SJ
Tang, WJ
Clement, KH
Eaton, LJ
Kelly-Cirino, CD
Mckee, ML
Powell, BS
Bishop, BL
Rudge, TL
Shine, N
Verma, A
Willis, MS
Morse, SA
AF Hughes, Molly A.
Burns, Drusilla L.
Juris, Stephen J.
Tang, Wei-Jen
Clement, Kristin H.
Eaton, Linda J.
Kelly-Cirino, Cassandra D.
McKee, Marian L.
Powell, Bradford S.
Bishop, Brian L.
Rudge, Thomas L.
Shine, Nancy
Verma, Anita
Willis, Melissa Swope
Morse, Stephen A.
TI The Case for Developing Consensus Standards for Research in Microbial
Pathogenesis: Bacillus anthracis Toxins as an Example
SO INFECTION AND IMMUNITY
LA English
DT Editorial Material
ID PUBLIC-HEALTH MANAGEMENT; RESISTANT STAPHYLOCOCCUS-AUREUS; LETHAL TOXIN;
BIOLOGICAL WEAPON; TRANSCRIPTIONAL RESPONSES; MURINE MACROPHAGES; GENE
ONTOLOGY; EDEMA TOXIN; CELL-TYPE; A TOXIN
C1 [Hughes, Molly A.] Univ Virginia Hlth Sci Syst, Dept Med, Div Infect Dis, Charlottesville, VA 22908 USA.
[Burns, Drusilla L.; Verma, Anita] US FDA, Lab Resp & Special Pathogens Ctr, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA.
[Juris, Stephen J.] Cent Michigan Univ, Dept Biol, Mt Pleasant, MI 48859 USA.
[Juris, Stephen J.] Cent Michigan Univ, Dept Chem, Mt Pleasant, MI 48859 USA.
[Tang, Wei-Jen; Bishop, Brian L.] Univ Chicago, Ctr Integrat Sci, Ben May Dept Canc Res, Chicago, IL 60637 USA.
[Clement, Kristin H.; Rudge, Thomas L.] Battelle Biomed Res Ctr, Battelle Mem Inst, W Jefferson, OH 43162 USA.
[Eaton, Linda J.; Shine, Nancy] List Biol Labs Inc, Campbell, CA 95008 USA.
[Kelly-Cirino, Cassandra D.] New York State Dept Hlth, Wadsworth Ctr, Div Infect Dis, Biodefense Lab,David Axelrod Inst, Albany, NY 12201 USA.
[McKee, Marian L.; Willis, Melissa Swope] ATCC, Manassas, VA 20110 USA.
[Powell, Bradford S.] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA.
[Morse, Stephen A.] Ctr Dis Control & Prevent, Div Bioterrorism Preparedness & Response, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA.
RP Hughes, MA (reprint author), Univ Virginia Hlth Syst, Dept Med, Div Infect Dis & Int Hlth, POB 800513, Charlottesville, VA 22908 USA.
EM mah3x@virginia.edu
OI Tang, Wei-Jen/0000-0002-8267-8995; Kelly-Cirino,
Cassandra/0000-0002-4526-8487
NR 31
TC 2
Z9 2
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD OCT
PY 2009
VL 77
IS 10
BP 4182
EP 4186
DI 10.1128/IAI.00368-09
PG 5
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 496ER
UT WOS:000269952800002
PM 19651858
ER
PT J
AU McKinney, W
Chen, B
Frazer, D
AF McKinney, Walter
Chen, Bean
Frazer, Dave
TI Computer controlled multi-walled carbon nanotube inhalation exposure
system
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Carbon nanotube; inhalation exposure; exposure system; computer control;
particle generation; particle distribution; feedback control
ID ULTRAFINE PARTICLES
AB Inhalation exposure systems are necessary tools for determining the dose-response relationship of inhaled toxicants under a variety of exposure conditions. The objective of this project was to develop an automated computer controlled system to expose small laboratory animals to precise concentrations of airborne multi-walled carbon nanotubes (MWCNT). An aerosol generator was developed which was capable of suspending a respirable fraction of multi-walled carbon nanotubes from bulk material. The output of the generator was used to expose small laboratory animals to constant aerosol concentrations up to 12 mg/m(3). Particle distribution and morphology of the MWCNT aerosol delivered to the exposure chamber were measured and compared to samples previously taken from air inside a facility that produces MWCNT. The comparison showed the MWCNT generator was producing particles similar in size and shape to those found in a work environment. The inhalation exposure system combined air flow controllers, particle monitors, data acquisition devices, and custom software with automatic feedback control to achieve constant and repeatable exposure chamber temperature, relative humidity, pressure, aerosol concentration, and particle size distribution. The automatic control algorithm was capable of maintaining the mean aerosol concentration to within 0.1 mg/m(3) of the selected target value, and it could reach 95% of the target value in less than 10 minutes during the start-up of an inhalation exposure. One of the major advantages of this system was that once the exposure parameters were selected, a minimum amount of operator intervention was required over the exposure period.
C1 [McKinney, Walter; Chen, Bean; Frazer, Dave] CDC NIOSH, Ctr Dis Control & Prevent, Morgantown, WV USA.
RP McKinney, W (reprint author), NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM wdm9@cdc.gov
NR 11
TC 31
Z9 31
U1 1
U2 14
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 0895-8378
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD OCT
PY 2009
VL 21
IS 12
BP 1053
EP 1061
DI 10.1080/08958370802712713
PG 9
WC Toxicology
SC Toxicology
GA 543YZ
UT WOS:000273619200010
PM 19555230
ER
PT J
AU Kazerouni, NN
Shah, N
Lathrop, S
Landen, MG
AF Kazerouni, N. Neely
Shah, N.
Lathrop, S.
Landen, M. G.
TI Non-firearm-related homicide, New Mexico, 2001-3
SO INJURY PREVENTION
LA English
DT Article
ID NEW-YORK-CITY; UNITED-STATES; ALCOHOL-USE; VIOLENCE; VICTIMS; SUICIDE;
DEATHS; URBANIZATION; DETERMINANTS; UPDATE
AB Objective: New Mexico (NM) has the highest rate of non-firearm-related homicide in the USA and ranks 20th in firearm-related homicides. Because non-firearm-related homicides are inadequately described in the literature, characterisation of non-firearm-related homicide victims will enhance efforts to reduce homicides.
Methods: Homicide victims were identified through the Office of the Medical Investigator. Age-specific and age-adjusted homicide death rates were calculated for 2001-3 by sex and race/ethnicity, and associations between covariates and non-firearm-related homicide were measured.
Results: Non-firearm-related homicides comprised 33% of US homicide victims, 47% of NM homicide victims, and 74% of NM American Indian (AI) homicide victims. Of 212 NM non-firearm-related homicide victims, 37% had been beaten, 32% had been stabbed, and 12% had been strangled. Females comprised 30% of non-firearm-related homicide victims and 18% of firearm-related homicide victims. A blood alcohol concentration (BAC) >= 0.08 mg/dl was detected among 43% of non-firearm-related (61% of AI) and 33% of firearm-related (50% of AI) homicide victims. Non-firearm-related homicide rates were highest among AI men aged 25-34 years (31/100 000). Non-firearm-related homicide victims were more likely than firearm-related victims to be AI (adjusted odds ratio (AOR) 4.20; 95% CI 2.16 to 8.16) and female (AOR 2.05; 95% CI 1.27 to 3.31), and to have had a BAC >= 0.08 mg/dl (AOR 1.65; 95% CI 1.08 to 2.52).
Conclusions: Homicide-prevention efforts among AIs in NM should focus on non-firearm-related homicides. The association between excessive drinking and non-firearm-related homicide should be further characterised. Continued surveillance for non-firearm-related homicides will assist these efforts.
C1 [Kazerouni, N. Neely; Shah, N.; Landen, M. G.] New Mexico Dept Hlth, Epidemiol & Response Div, Santa Fe, NM 87502 USA.
[Kazerouni, N. Neely] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Atlanta, GA USA.
[Lathrop, S.] Univ New Mexico, Hlth Sci Ctr, Off Med Investigator, Albuquerque, NM 87131 USA.
RP Landen, MG (reprint author), New Mexico Dept Hlth, Epidemiol & Response Div, 1190 St Francis Dr N1320,POB 26110, Santa Fe, NM 87502 USA.
EM michael.landen@state.nm.us
NR 40
TC 1
Z9 1
U1 0
U2 2
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1353-8047
J9 INJURY PREV
JI Inj. Prev.
PD OCT
PY 2009
VL 15
IS 5
BP 317
EP 321
DI 10.1136/ip.2008.020180
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 502UJ
UT WOS:000270485400006
PM 19805600
ER
PT J
AU Halpin, J
Greenspan, AI
Haileyesus, T
Annest, JL
AF Halpin, J.
Greenspan, A. I.
Haileyesus, T.
Annest, J. L.
TI The effect of counting principal and secondary injuries on national
estimates of motor vehicle-related trauma: a NEISS-AIP special study
SO INJURY PREVENTION
LA English
DT Article
ID MULTIPLE INJURIES; UNITED-STATES
AB Objective: To demonstrate the effect of including both principal and secondary injuries in the calculation of national estimates of non-fatal motor vehicle-related injury, using the National Electronic Injury Surveillance System-All Injury Program (NEISS-AIP).
Methods: The setting was a stratified sample of 15 US hospital emergency departments selected among 50 NEISS-AIP hospitals which agreed to participate in the study. Non-fatal injury data from a special study of the 2004 NEISS-AIP were analysed which allowed up to five injuries to be coded per case. National estimates of number and rate of injuries for 2004 were calculated, first using principal injuries alone, then by including principal and secondary injuries.
Results: An estimated 4 833 626 principal and secondary injuries were sustained by the estimated 2 893 782 motor vehicle occupants involved in a crash and treated in US hospital emergency departments (EDs) in 2004. This represents a 67% increase in the total number of injuries compared with an estimate of principal injury alone. Incidence of contusions/abrasions and lower trunk injuries rose most steeply among broad injury types, and whiplash injury rose 18% in number and rate. A significantly lower percentage of cases with a single listed injury were hospitalised (5%) compared with those who sustained multiple injuries (8%).
Conclusions: Based on an analysis of NEISS-AIP special study data, the inclusion of both principal and secondary injuries in national estimates of motor vehicle-related occupant injury would provide a more comprehensive report of non-fatal injuries treated in US hospital EDs. Other countries with ED-based surveillance systems could consider reporting multiple injuries when assessing injury count associated with motor vehicle trauma requiring ED care.
C1 [Halpin, J.; Greenspan, A. I.] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA.
[Haileyesus, T.; Annest, J. L.] Ctr Dis Control & Prevent, Off Stat & Programming, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA.
RP Halpin, J (reprint author), Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway NE,Mailstop F62, Atlanta, GA 30341 USA.
EM jhalpin@cdc.gov
FU National Center for Injury Prevention and Control, Centers for Disease
Control and Prevention
FX This study was partially funded by the National Center for Injury
Prevention and Control, Centers for Disease Control and Prevention.
NR 16
TC 6
Z9 6
U1 0
U2 2
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1353-8047
J9 INJURY PREV
JI Inj. Prev.
PD OCT
PY 2009
VL 15
IS 5
BP 328
EP 333
DI 10.1136/ip.2009.021691
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 502UJ
UT WOS:000270485400008
PM 19805602
ER
PT J
AU Powell, K
Huang, L
AF Powell, Krista
Huang, Laurence
TI The ART of caring for patients with HIV infection in the ICU
SO INTENSIVE CARE MEDICINE
LA English
DT Editorial Material
ID ACTIVE ANTIRETROVIRAL THERAPY; IMMUNODEFICIENCY-VIRUS-INFECTION;
INTENSIVE-CARE-UNIT; ACUTE LUNG INJURY; ERA; SURVIVAL; OUTCOMES;
VENTILATION; PNEUMONIA; MORTALITY
C1 [Powell, Krista] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Powell, Krista] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
[Huang, Laurence] Univ Calif San Francisco, San Francisco Gen Hosp, Div HIV AIDS, San Francisco, CA 94143 USA.
[Huang, Laurence] Univ Calif San Francisco, San Francisco Gen Hosp, Div Pulm & Crit Care Med, San Francisco, CA 94143 USA.
RP Powell, K (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS E-10, Atlanta, GA 30333 USA.
EM kpow05@gmail.com
RI Andrade, Hugo/M-6631-2013;
OI Andrade, Hugo/0000-0001-6781-6125; Huang, Laurence/0000-0003-3888-2195
FU NHLBI NIH HHS [K24 HL087713]
NR 20
TC 3
Z9 3
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0342-4642
J9 INTENS CARE MED
JI Intensive Care Med.
PD OCT
PY 2009
VL 35
IS 10
BP 1659
EP 1661
DI 10.1007/s00134-009-1578-1
PG 3
WC Critical Care Medicine
SC General & Internal Medicine
GA 498VD
UT WOS:000270171900002
PM 19636534
ER
PT J
AU Pierik, FH
Deddens, JA
Burdorf, A
Keizer-Schrama, SMPFD
de Jong, FH
Weber, RFA
AF Pierik, Frank H.
Deddens, James A.
Burdorf, Alex
Keizer-Schrama, Sabine M. P. F. de Muinck
de Jong, Frank H.
Weber, Rob F. A.
TI The hypothalamus-pituitary-testis axis in boys during the first six
months of life: a comparison of cryptorchidism and hypospadias cases
with controls
SO INTERNATIONAL JOURNAL OF ANDROLOGY
LA English
DT Article
DE AHM; cryptorchidism; FSH; hypospadias; inhibin B; LH; newborn boys;
testosterone
ID SERUM INHIBIN-B; ANTI-MULLERIAN HORMONE; FOLLICLE-STIMULATING-HORMONE;
LUTEINIZING-HORMONE; BINDING GLOBULIN; ADULT MEN; TESTOSTERONE; INFANTS;
PUBERTY; SPERMATOGENESIS
AB P>It is inconclusive whether the feedback mechanisms of the hypothalamus-pituitary-testis (HTP) axis are already established in the first 6 months of life, partly due to the dramatic changes in HPT-axis hormone levels over this period. Moreover, it is unclear whether these hormone levels are aberrant in boys with cryptorchidism or hypospadias, and therefore predictive for future fertility. We studied the regulation mechanisms of the HTP axis, and the effect of age, in boys 1-6 months of age. Secondly, we studied testicular function - as reflected by HPT hormones - in newborns with cryptorchidism or hypospadias. Sera from a population sample of infants with cryptorchidism (n = 43), hypospadias (n = 41) and controls (n = 113) were analyzed for inhibin B, anti-Mullerian hormone (AMH), testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and sex hormone binding globulin (SHBG). LH, testosterone, non-shbg-bound testosterone (NSBT), and AHM levels showed significant age-related trends. After age-correction, a negative correlation between FSH and inhibin B was observed (r = -0.43). The only significant group-differences were lower testosterone and NSBT levels in cryptorchidism cases, with a mean testosterone of 1.8 and 2.6 nmol/L and a mean NSBT of 0.48 and 0.70 nmol/L for cryptorchidism cases and controls, respectively. The higher levels of LH, testosterone, and NSBT in boys born pre-term or with a low birthweight indicate that abnormal prenatal development may determine postnatal testis function. Our results support the hypothesis that the inhibin B - FSH feedback loop is already functional before puberty. The lower testosterone and NSBT levels indicate that disturbed Leydig cell function can already be detected early after birth in cryptorchid boys.
C1 [Pierik, Frank H.; Weber, Rob F. A.] Erasmus MC, Dept Androl, Rotterdam, Netherlands.
[Pierik, Frank H.; Burdorf, Alex] Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands.
[Deddens, James A.] NIOSH, Cincinnati, OH 45226 USA.
[Keizer-Schrama, Sabine M. P. F. de Muinck] Erasmus MC, Dept Pediat Endocrinol, Rotterdam, Netherlands.
[de Jong, Frank H.] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
RP Pierik, FH (reprint author), TNO Environm Hlth & Safety, Dept Environm & Hlth, POB 49, NL-2600 AA Delft, Netherlands.
EM frank.pierik@tno.nl
RI Burdorf, Alex/A-2226-2008; Perez , Claudio Alejandro/F-8310-2010
OI Burdorf, Alex/0000-0003-3129-2862; Perez , Claudio
Alejandro/0000-0001-9688-184X
FU European Chemical Industry Council (EMSG-CEFIC)
FX The Endocrine Modulators Study Group of the European Chemical Industry
Council (EMSG-CEFIC) is acknowledged for financial support. The sponsors
of the study had no role in study design, data collection, data
interpretation, or reporting.
NR 38
TC 18
Z9 18
U1 0
U2 1
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0105-6263
J9 INT J ANDROL
JI Int. J. Androl.
PD OCT
PY 2009
VL 32
IS 5
BP 453
EP 461
DI 10.1111/j.1365-2605.2008.00877.x
PG 9
WC Andrology
SC Endocrinology & Metabolism
GA 491PJ
UT WOS:000269591000003
PM 18336537
ER
PT J
AU Warren, CW
Sinha, DN
Lee, J
Lea, V
Jones, NR
AF Warren, Charles W.
Sinha, Dhirendra N.
Lee, Juliette
Lea, Veronica
Jones, Nathan R.
TI Tobacco Use, Exposure to Secondhand Smoke, and Training on Cessation
Counseling Among Nursing Students: Cross-Country Data from the Global
Health Professions Student Survey (GHPSS), 2005-2009
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE tobacco use; health professionals; nursing students; counseling training
ID BELIEFS
AB The Nursing Global Health Professions Student Survey (GHPSS) has been conducted in schools in 39 countries and the Gaza Strip/West Bank (identified as "sites" for the remainder of this paper). In half the sites, over 20% of the students currently smoked cigarettes, with males having higher rates than females in 22 sites. Over 60% of students reported having been exposed to secondhand smoke in public places in 23 of 39 sites. The majority of students recognized that they are role models in society, believed they should receive training on counseling patients to quit using tobacco, but few reported receiving any formal training. Tobacco control efforts must discourage tobacco use among health professionals, promote smoke free workplaces, and implement programs that train health professionals in effective cessation-counseling techniques.
C1 [Warren, Charles W.; Lee, Juliette; Lea, Veronica] US Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA.
[Sinha, Dhirendra N.] WHO, Tobacco Free Initiat, SE Asia Reg, Delhi, India.
[Jones, Nathan R.] Univ Wisconsin, Paul P Carbone Comprehens Canc Ctr, Madison, WI 53705 USA.
RP Warren, CW (reprint author), US Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA.
EM wcw1@cdc.gov; sinhad@searo.who.int; jpa7@cdc.gov; vcl7@cdc.gov;
nrjones@uwcarbone.wisc.edu
NR 18
TC 22
Z9 23
U1 3
U2 7
PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
PI BASEL
PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD OCT
PY 2009
VL 6
IS 10
BP 2534
EP 2549
DI 10.3390/ijerph6102534
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 512UL
UT WOS:000271276200002
PM 20054453
ER
PT J
AU Adjemian, JZ
Howell, J
Holzbauer, S
Harris, J
Recuenco, S
McQuiston, J
Chester, T
Lynfield, R
Devries, A
Belay, E
Sejvar, J
AF Adjemian, Jennifer Zipser
Howell, James
Holzbauer, Stacy
Harris, Julie
Recuenco, Sergio
McQuiston, Jennifer
Chester, Thomas
Lynfield, Ruth
Devries, Aaron
Belay, Ermias
Sejvar, Jim
TI A Clustering of Immune-mediated Polyradiculoneuropathy among Swine
Abattoir Workers Exposed to Aerosolized Porcine Brains, Indiana, United
States
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE neuropathy; swine; porcine; abattoir; brain; aerosolization
ID EXPERIMENTAL ALLERGIC NEURITIS; ENCEPHALOMYELITIS; PROTEIN
AB In November 2007 a novel neuropathy, immune-mediated polyradiculoneuropathy (IP), was identified among workers at a Minnesota swine abattoir where a unique compressed air technique was used to remove porcine brains. An epidemiologic investigation at another abattoir in Indiana that also uses this process was launched to evaluate workers self-reporting neurologic illness compatible with IP. A nested case-control study was performed to identify cases and risk factors. Six confirmed, one probable, and three possible IP cases were detected. IP cases were 28-52 years old, of Latino origin, and 62.5% female. Onset dates ranged from April 2005-December 2007; 60% were hospitalized. IP cases at this plant were similar in clinical presentation and exposure risks to those detected in Minnesota. Swine abattoirs using similar brain extraction methods should discontinue this process.
C1 [Adjemian, Jennifer Zipser; Recuenco, Sergio; McQuiston, Jennifer; Belay, Ermias; Sejvar, Jim] US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Chester, Thomas] Indiana State Dept Hlth, Indianapolis, IN 46202 USA.
[Holzbauer, Stacy; Lynfield, Ruth; Devries, Aaron] Minnesota Dept Hlth, St Paul, MN USA.
RP Adjemian, JZ (reprint author), US Ctr Dis Control & Prevent, 1600 Clifton Rd, Atlanta, GA 30333 USA.
EM jadjemian@bop.gov
RI Belay, Ermias/A-8829-2013;
OI Recuenco-Cabrera, Sergio/0000-0002-8446-7411
FU Centers for Disease Control and Prevention; Minnesota Department of
Health; Indiana State Department of Health
FX Funding for this study was received from: Centers for Disease Control
and Prevention; Minnesota Department of Health; Indiana State Department
of Health.
NR 8
TC 4
Z9 4
U1 1
U2 2
PU ABEL PUBLICATION SERVICES
PI BURLINGTON
PA 1611 AQUINAS COURT, BURLINGTON, NC 27215 USA
SN 1077-3525
J9 INT J OCCUP ENV HEAL
JI Int. J. Occup. Environ. Health
PD OCT-DEC
PY 2009
VL 15
IS 4
BP 331
EP 338
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 514ZP
UT WOS:000271436000001
PM 19886343
ER
PT J
AU Arcury, TA
Grzywacz, JG
Isom, S
Whalley, LE
Vallejos, QM
Chen, HY
Galvan, L
Barr, DB
Quandt, SA
AF Arcury, Thomas A.
Grzywacz, Joseph G.
Isom, Scott
Whalley, Lara E.
Vallejos, Quirina M.
Chen, Haiying
Galvan, Leonardo
Barr, Dana B.
Quandt, Sara A.
TI Seasonal Variation in the Measurement of Urinary Pesticide Metabolites
among Latino Farmworkers in Eastern North Carolina
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE farmworker; agriculture; occupational health; pesticide exposure;
biomonitoring
ID ORGANOPHOSPHORUS PESTICIDES; EXPOSURE; CHILDREN; HEALTH; COMMUNITY;
VIRGINIA
AB This analysis describes the detection of urinary pesticide metabolites for Latino farmworkers across the agricultural season. Two hundred and eighty four farmworkers were recruited from 44 camps in eastern North Carolina in 2007. Data were collected at one month intervals for a total of 939 data points. The OP insecticide metabolites 3,5,6-trichloropyridinol (46.2%), malathion dicarboxylic acid (27.7%), and para-nitrophenol (97.4%); the pyrethroid metabolite 3-phenoxybenzoic acid (56.4%); and the herbicides 2,4-D (68.1%), acetochlor (29.2%), and metolachlor (16.9%) were found in sizable percentages of the samples. The percentage of farmworkers for whom metabolites were detected varied across the agricultural season. None of the farmworker characteristics were significantly associated with the detection of any pesticide metabolite. Seasonality overrides the effects of other farmworker characteristics in predicting detection of pesticide urinary metabolites. Future research needs to collect multiple exposure measures at frequent intervals over an extended period to characterize factors associated with exposure.
C1 [Arcury, Thomas A.; Grzywacz, Joseph G.; Whalley, Lara E.; Vallejos, Quirina M.] Wake Forest Univ, Dept Family & Community Med, Sch Med, Winston Salem, NC 27157 USA.
[Isom, Scott; Chen, Haiying] Wake Forest Univ, Dept Biostat Sci, Sch Med, Div Publ Hlth Sci, Winston Salem, NC 27157 USA.
[Galvan, Leonardo] N Carolina Farmworkers Project, Benson, NC USA.
[Barr, Dana B.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Quandt, Sara A.] Wake Forest Univ, Dept Epidemiol & Prevent, Sch Med, Div Publ Hlth Sci, Winston Salem, NC 27157 USA.
RP Arcury, TA (reprint author), Wake Forest Univ, Dept Family & Community Med, Sch Med, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM tarcury@wfubmc.edu
RI Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013;
OI Grzywacz, Joseph/0000-0002-2308-7781
FU National Institute of Environmental Health Sciences, United States
National Institutes of Health [R01-ES008739]
FX This study was supported by a grant from the National Institute of
Environmental Health Sciences, United States National Institutes of
Health (R01-ES008739).
NR 19
TC 30
Z9 32
U1 0
U2 4
PU ABEL PUBLICATION SERVICES
PI BURLINGTON
PA 1611 AQUINAS COURT, BURLINGTON, NC 27215 USA
SN 1077-3525
J9 INT J OCCUP ENV HEAL
JI Int. J. Occup. Environ. Health
PD OCT-DEC
PY 2009
VL 15
IS 4
BP 339
EP 350
PG 12
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 514ZP
UT WOS:000271436000002
PM 19886344
ER
PT J
AU Gust, DA
Wiegand, RE
Para, M
Chen, RT
Bartholow, BN
AF Gust, Deborah A.
Wiegand, Ryan E.
Para, Michael
Chen, Robert T.
Bartholow, Brad N.
TI HIV Testing Outside of the Study Among Men Who Have Sex With Men
Participating in an HIV Vaccine Efficacy Trial
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article; Proceedings Paper
CT AIDS Vaccine 2008 Conference
CY OCT 13-16, 2008
CL Cape Town, SOUTH AFRICA
SP NIAID, Div AIDS, NIH, Div AIDS
DE differential risk behavior; HIV test; HIV vaccine clinical trial; lost
to follow up
AB Objectives: Participants who obtain an HIV test outside of an HIV vaccine efficacy trial could potentially unblind themselves which could result in differential behavior change and loss to follow-up based on assignment status. In a reanalysis of the VaxGen VAX004 data, the objectives were to determine: 1) the proportion of participants who were tested for HIV outside of the study (despite instructions not to do this) and reasons why; 2) demographic and risk factors associated with reported testing outside of the study; and 3) if outside testing was related to participant loss to follow-up.
Methods: Analyses were restricted to men who have sex with men (MSM) who completed a survey at one or more annual visits in a randomized, double-blind, placebo-controlled efficacy trial of a bivalent rgp 120 vaccine conducted from 1998-2002. A generalized linear mixture model assessed associations with outside testing.
Results: Despite instructions to the contrary, 16.9% (791/4670) of MSM reported being tested for HIV outside of the study, with the top two reasons being a) medical provider request (28.1%) and b) insurance requirement (17.1%). Increased odds of self-reported outside testing was associated with site location, reporting one or more sexually transmitted infections (STIs), joining the trial because of the belief that participation might confer some protection against HIV infection, engaging in unprotected anal sex, and being lost to follow-up. Decreased odds of self-reported outside testing was associated with perceived study arm assignment to vaccine or uncertainty about study arm assignment compared to placebo.
Conclusions: To avoid biases such as differential risk behavior and loss to follow-up based on perceived assignment status, initiating additional procedures to reduce the likelihood of outside testing will be important to assure the validity of future study results.
C1 [Gust, Deborah A.; Wiegand, Ryan E.; Chen, Robert T.; Bartholow, Brad N.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis TB & STD Preven, Atlanta, GA USA.
[Para, Michael] Ohio State Univ, Coll Med, Dept Internal Med, Columbus, OH 43210 USA.
RP Gust, DA (reprint author), CDC, Epidemiol Branch, HIV Vaccine & Special Studies Team, Div HIV AIDS Prevent, 1600 Clifton Rd,Mail Stop E-45, Atlanta, GA 30333 USA.
EM dgust@cdc.gov
NR 14
TC 4
Z9 4
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD OCT 1
PY 2009
VL 52
IS 2
BP 294
EP 298
PG 5
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 499GQ
UT WOS:000270206500020
PM 19574927
ER
PT J
AU Grosse, SD
Flores, AL
Ouyang, LJ
Robbins, JM
Tilford, JM
AF Grosse, Scott D.
Flores, Alina L.
Ouyang, Lijing
Robbins, James M.
Tilford, John M.
TI Impact of Spina Bifida on Parental Caregivers: Findings from a Survey of
Arkansas Families
SO JOURNAL OF CHILD AND FAMILY STUDIES
LA English
DT Article
DE Caregiving; Disability; Quality of life; Parental stress; Time use
ID QUALITY-OF-LIFE; CEREBRAL-PALSY; DOWN-SYNDROME; CHILDREN; HEALTH;
DISABILITY; MOTHERS; STRESS; ADAPTATION; SEVERITY
AB The well-being of caregivers of children with spina bifida and other conditions is an important topic. We interviewed the primary caregivers of 98 children aged 0 17 years with spina bifida sampled from a population based birth defects registry in Arkansas and the caregivers of 49 unaffected children. Measures of caregiver wellbeing were compared between the groups and by level of lesion (sacral, lower lumbar, and upper lumbar/thoracic). We performed linear and logistic regression analysis to test the associations controlling for other characteristics. Among caregivers of children with spina bifida, the average number of hours of sleep was significantly less than reported by other caregivers and was associated with lesion level among children less than 7 years of age. Significant associations, often varying by child age, were also found for the caregiver's reports of lower Quality of Well-Being (QWB) score, often feeling blue, rarely feeling happy, fair or poor health, lack of leisure days, and not hosting friends, but no significant association was found with not visiting friends. The intensive long-term care required by children with spina bifida, particularly by those with higher lesions, can negatively impact caregiver health and well-being. Support for these caregivers is needed.
C1 [Grosse, Scott D.; Flores, Alina L.; Ouyang, Lijing] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Robbins, James M.; Tilford, John M.] Univ Arkansas Med Sci, Ctr Appl Res & Evaluat, Coll Med, Little Rock, AR 72205 USA.
[Robbins, James M.; Tilford, John M.] Arkansas Childrens Hosp, Little Rock, AR 72202 USA.
RP Grosse, SD (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E-88, Atlanta, GA 30333 USA.
EM sgg4@cdc.gov
OI Robbins, James/0000-0003-2200-1947
NR 35
TC 19
Z9 19
U1 1
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1062-1024
J9 J CHILD FAM STUD
JI J. Child Fam. Stud.
PD OCT
PY 2009
VL 18
IS 5
BP 574
EP 581
DI 10.1007/s10826-009-9260-3
PG 8
WC Family Studies; Psychology, Developmental; Psychiatry
SC Family Studies; Psychology; Psychiatry
GA 507GV
UT WOS:000270841000008
ER
PT J
AU Wolk, DM
Blyn, LB
Hall, TA
Sampath, R
Ranken, R
Ivy, C
Melton, R
Matthews, H
White, N
Li, F
Harpin, V
Ecker, DJ
Limbago, B
McDougal, LK
Wysocki, VH
Cai, M
Carroll, KC
AF Wolk, Donna M.
Blyn, Lawrence B.
Hall, Thomas A.
Sampath, Rangarajan
Ranken, Raymond
Ivy, Cristina
Melton, Rachael
Matthews, Heather
White, Neill
Li, Feng
Harpin, Vanessa
Ecker, David J.
Limbago, Brandi
McDougal, Linda K.
Wysocki, Vicki H.
Cai, Mian
Carroll, Karen C.
TI Pathogen Profiling: Rapid Molecular Characterization of Staphylococcus
aureus by PCR/Electrospray Ionization-Mass Spectrometry and Correlation
with Phenotype
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID PANTON-VALENTINE LEUKOCIDIN; FIELD GEL-ELECTROPHORESIS;
POLYMERASE-CHAIN-REACTION; METHICILLIN-RESISTANT; MUPIROCIN RESISTANCE;
UNITED-STATES; VIRULENCE DETERMINANTS; NECROTIZING PNEUMONIA; GENETIC
ORGANIZATION; LUKE-LUKD
AB There are few diagnostic methods that readily distinguish among community-acquired methicillin (meticillin)-resistant Staphylococcus aureus strains, now frequently transmitted within hospitals. We describe a rapid and high-throughput method for bacterial profiling of staphylococcal isolates. The method couples PCR to electrospray ionization-mass spectrometry (ESI-MS) and is performed on a platform suitable for use in a diagnostic laboratory. This profiling technology produces a high-resolution genetic signature indicative of the presence of specific genetic elements that represent distinctive phenotypic features. The PCR/ESI-MS signature accurately identified genotypic determinants consistent with phenotypic traits in well-characterized reference and clinical isolates of S. aureus. Molecular identification of the antibiotic resistance genes correlated strongly with phenotypic in vitro resistance. The identification of toxin genes correlated with independent PCR analyses for the toxin genes. Finally, isolates were correctly classified into genotypic groups that correlated with genetic clonal complexes, repetitive-element-based PCR patterns, or pulsed-field gel electrophoresis types. The high-throughput PCR/ESI-MS assay should improve clinical management of staphylococcal infections.
C1 [Wolk, Donna M.] Univ Arizona, Dept Pathol, Inst BIO5, Tucson, AZ 85724 USA.
[Blyn, Lawrence B.; Hall, Thomas A.; Sampath, Rangarajan; Ranken, Raymond; Ivy, Cristina; Melton, Rachael; Matthews, Heather; White, Neill; Li, Feng; Harpin, Vanessa; Ecker, David J.] Abbott Mol Inc, Ibis Biosci, Carlsbad, CA 92008 USA.
[Limbago, Brandi; McDougal, Linda K.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
[Cai, Mian; Carroll, Karen C.] Johns Hopkins Univ, Baltimore, MD 21287 USA.
RP Wolk, DM (reprint author), Univ Arizona, Dept Pathol, Inst BIO5, 1501 N Campbell Ave,POB 245059, Tucson, AZ 85724 USA.
EM dwolk@email.arizona.edu
FU Ibis Biosciences
FX The findings and conclusions in this report are those of the authors and
do not necessarily represent the views of the Centers for Disease
Control and Prevention.
NR 44
TC 36
Z9 36
U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD OCT
PY 2009
VL 47
IS 10
BP 3129
EP 3137
DI 10.1128/JCM.00709-09
PG 9
WC Microbiology
SC Microbiology
GA 501BC
UT WOS:000270351700008
PM 19710268
ER
PT J
AU Balajee, SA
Kano, R
Baddley, JW
Moser, SA
Marr, KA
Alexander, BD
Andes, D
Kontoyiannis, DP
Perrone, G
Peterson, S
Brandt, ME
Pappas, PG
Chiller, T
AF Balajee, S. Arunmozhi
Kano, Rui
Baddley, John W.
Moser, Stephen A.
Marr, Kieren A.
Alexander, Barbara D.
Andes, David
Kontoyiannis, Dimitrios P.
Perrone, Giancarlo
Peterson, Stephen
Brandt, Mary E.
Pappas, Peter G.
Chiller, Tom
TI Molecular Identification of Aspergillus Species Collected for the
Transplant-Associated Infection Surveillance Network
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID HEMATOPOIETIC STEM-CELL; INVASIVE ASPERGILLOSIS; SP NOV.; FUMIGATUS;
LENTULUS; PCR
AB A large aggregate collection of clinical isolates of aspergilli (n = 218) from transplant patients with proven or probable invasive aspergillosis was available from the Transplant-Associated Infection Surveillance Network, a 6-year prospective surveillance study. To determine the Aspergillus species distribution in this collection, isolates were subjected to comparative sequence analyses by use of the internal transcribed spacer and beta-tubulin regions. Aspergillus fumigatus was the predominant species recovered, followed by A. flavus and A. niger. Several newly described species were identified, including A. lentulus and A. calidoustus; both species had high in vitro MICs to multiple antifungal drugs. Aspergillus tubingensis, a member of the A. niger species complex, is described from clinical specimens; all A. tubingensis isolates had low in vitro MICs to antifungal drugs.
C1 [Balajee, S. Arunmozhi; Kano, Rui; Brandt, Mary E.; Chiller, Tom] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA.
[Baddley, John W.; Pappas, Peter G.] Univ Alabama, Dept Med, Birmingham, AL 35294 USA.
[Moser, Stephen A.] Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA.
[Baddley, John W.] Birmingham Vet Affairs Med Ctr, Dept Med, Birmingham, AL USA.
[Marr, Kieren A.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[Marr, Kieren A.] Johns Hopkins Univ, Baltimore, MD USA.
[Alexander, Barbara D.] Duke Univ, Durham, NC USA.
[Andes, David] Univ Wisconsin, Madison, WI USA.
[Kontoyiannis, Dimitrios P.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Perrone, Giancarlo] CNR, Inst Sci Food Prod, Bari, Italy.
[Peterson, Stephen] USDA, Natl Ctr Agr Utilizat Res, Peoria, IL USA.
RP Balajee, SA (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, Mail Stop G 11,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM fir3@cdc.gov
RI Moser, Stephen/A-1168-2008; Perrone, Giancarlo/O-7475-2014
OI Perrone, Giancarlo/0000-0002-3841-6066
FU Nihon University in Japan; NIH [K23AI064613]
FX The findings and conclusions in this article are those of the authors
and do not necessarily represent the views of the Centers for Disease
Control and Prevention.
NR 18
TC 92
Z9 96
U1 1
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD OCT
PY 2009
VL 47
IS 10
BP 3138
EP 3141
DI 10.1128/JCM.01070-09
PG 4
WC Microbiology
SC Microbiology
GA 501BC
UT WOS:000270351700009
PM 19675215
ER
PT J
AU Baddley, JW
Marr, KA
Andes, DR
Walsh, TJ
Kauffman, CA
Kontoyiannis, DP
Ito, JI
Balajee, SA
Pappas, PG
Moser, SA
AF Baddley, John W.
Marr, Kieren A.
Andes, David R.
Walsh, Thomas J.
Kauffman, Carol A.
Kontoyiannis, Dimitrios P.
Ito, James I.
Balajee, S. Arunmozhi
Pappas, Peter G.
Moser, Stephen A.
TI Patterns of Susceptibility of Aspergillus Isolates Recovered from
Patients Enrolled in the Transplant-Associated Infection Surveillance
Network
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID AMPHOTERICIN-B; IN-VITRO; INVASIVE ASPERGILLOSIS; CROSS-RESISTANCE;
AZOLE RESISTANCE; FUMIGATUS; ITRACONAZOLE; VORICONAZOLE; TERREUS;
RAVUCONAZOLE
AB We analyzed antifungal susceptibilities of 274 clinical Aspergillus isolates from transplant recipients with proven or probable invasive aspergillosis collected as part of the Transplant-Associated Infection Surveillance Network (TRANSNET) and examined the relationship between MIC and mortality at 6 or 12 weeks. Antifungal susceptibility testing was performed by the Clinical and Laboratory Standards Institute (CLSI) M38-A2 broth dilution method for amphotericin B (AMB), itraconazole (ITR), voriconazole (VOR), posaconazole (POS), and ravuconazole (RAV). The isolate collection included 181 Aspergillus fumigatus, 28 Aspergillus niger, 27 Aspergillus flavus, 22 Aspergillus terreus, seven Aspergillus versicolor, five Aspergillus calidoustus, and two Aspergillus nidulans isolates and two isolates identified as Aspergillus spp. Triazole susceptibilities were <= 4 mu g/ml for most isolates (POS, 97.6%; ITR, 96.3%; VOR, 95.9%; RAV, 93.5%). The triazoles were not active against the five A. calidoustus isolates, for which MICs were >= 4 mu g/ml. AMB inhibited 93.3% of isolates at an MIC of 1 mu g/ml. The exception was A. terreus, for which 15 (68%) of 22 isolates had MICs of >1 mu g/ml. One of 181 isolates of A. fumigatus showed resistance (MIC > 4 mu g/ml) to two of three azoles tested. Although there appeared to be a correlation of higher VOR MICs with increased mortality at 6 weeks, the relationship was not statistically significant (R(2) = 0.61; P = 0.065). Significant relationships of in vitro MIC to all-cause mortality at 6 and 12 weeks for VOR or AMB were not found.
C1 [Baddley, John W.; Pappas, Peter G.] Univ Alabama, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA.
[Baddley, John W.] Birmingham Vet Affairs Med Ctr, Infect Dis Sect, Dept Med, Birmingham, AL USA.
[Marr, Kieren A.] Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21205 USA.
[Andes, David R.] Univ Wisconsin, Dept Med, Div Infect Dis, Madison, WI USA.
[Walsh, Thomas J.] NCI, Pediat Oncol Branch, Bethesda, MD 20892 USA.
[Kauffman, Carol A.] Univ Michigan, Dept Med, Ann Arbor, MI 48109 USA.
[Kauffman, Carol A.] Vet Affairs Ann Arbor Healthcare Syst, Ann Arbor, MI USA.
[Kontoyiannis, Dimitrios P.] Univ Texas MD Anderson Canc Ctr, Dept Med, Houston, TX 77030 USA.
[Ito, James I.] City Hope Natl Med Ctr, Dept Med, Div Infect Dis, Duarte, CA 91010 USA.
[Balajee, S. Arunmozhi] Ctr Dis Control & Prevent, Div Mycot Dis, Atlanta, GA USA.
[Moser, Stephen A.] Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA.
RP Baddley, JW (reprint author), Univ Alabama, Dept Med, Div Infect Dis, 1900 Univ Blvd,229 Tinsley Harrison Tower, Birmingham, AL 35294 USA.
EM jbaddley@uab.edu
RI Moser, Stephen/A-1168-2008
FU NIH [K23AI064613]
FX J.W.B. is sponsored in part by NIH grant K23AI064613.
NR 30
TC 86
Z9 88
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD OCT
PY 2009
VL 47
IS 10
BP 3271
EP 3275
DI 10.1128/JCM.00854-09
PG 5
WC Microbiology
SC Microbiology
GA 501BC
UT WOS:000270351700029
PM 19692558
ER
PT J
AU Wesolowski, LG
Ethridge, SF
Martin, EG
Cadoff, EM
MacKellar, DA
AF Wesolowski, Laura G.
Ethridge, Steven F.
Martin, Eugene G.
Cadoff, Evan M.
MacKellar, Duncan A.
TI Rapid Human Immunodeficiency Virus Test Quality Assurance Practices and
Outcomes among Testing Sites Affiliated with 17 Public Health
Departments
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID PERFORMANCE; ASSAYS
AB Rapid human immunodeficiency virus testing is often conducted in nonclinical settings by staff with limited training, so quality assurance (QA) monitoring is critical to ensure accuracy of test results. Rapid tests (n = 86,749) were generally conducted according to manufacturers' instructions, but ongoing testing competency assessments and on-site QA monitoring were not uniformly conducted.
C1 [Wesolowski, Laura G.; Ethridge, Steven F.; MacKellar, Duncan A.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
[Martin, Eugene G.; Cadoff, Evan M.] UMDNJ Robert W Johnson Med Sch, Newark, NJ USA.
RP Wesolowski, LG (reprint author), CDC, 1600 Clifton Rd,MS E46, Atlanta, GA 30333 USA.
EM lig7@cdc.gov
NR 10
TC 2
Z9 2
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD OCT
PY 2009
VL 47
IS 10
BP 3333
EP 3335
DI 10.1128/JCM.01504-09
PG 3
WC Microbiology
SC Microbiology
GA 501BC
UT WOS:000270351700040
PM 19692557
ER
PT J
AU Brandt, ME
Gade, L
McCloskey, CB
Balajee, SA
AF Brandt, Mary E.
Gade, Lalitha
McCloskey, Cindy B.
Balajee, S. Arunmozhi
TI Atypical Aspergillus flavus Isolates Associated with Chronic Azole
Therapy
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID IMMUNOCOMPETENT HOSTS; PARANASAL SINUSES; PATHOGENS; MOLDS
AB A case of chronic sinus disease due to morphologically atypical Aspergillus flavus is described. Multiple fungal isolates sporulated poorly or not at all, displaying unusual color and microscopic morphology, including the absence of typical vesicles and phialides, which caused the isolates to resemble several other fungal genera superficially. The patient received multiple antifungal therapies over at least 10 years with various azole drugs, including voriconazole, itraconazole, and posaconazole. We speculate that this lengthy exposure to azole antifungal drugs may have caused or promoted the atypical morphology seen in these isolates.
C1 [Brandt, Mary E.; Gade, Lalitha; Balajee, S. Arunmozhi] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA.
[McCloskey, Cindy B.] Emory Univ Hosp, Atlanta, GA 30329 USA.
RP Brandt, ME (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, 600 Clifton Rd,Mailstop G-11, Atlanta, GA 30333 USA.
EM mbb4@cdc.gov
NR 12
TC 3
Z9 3
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD OCT
PY 2009
VL 47
IS 10
BP 3372
EP 3375
DI 10.1128/JCM.00671-09
PG 4
WC Microbiology
SC Microbiology
GA 501BC
UT WOS:000270351700051
PM 19656977
ER
PT J
AU Jia, HM
Moriarty, DG
Kanarek, N
AF Jia, Haomiao
Moriarty, David G.
Kanarek, Norma
TI County-Level Social Environment Determinants of Health-Related Quality
of Life Among US Adults: A Multilevel Analysis
SO JOURNAL OF COMMUNITY HEALTH
LA English
DT Article
DE BRFSS; Health-related quality-of-life; Multilevel model; Social
determinants of health; US counties; Social environment
ID SELF-RATED HEALTH; UNITED-STATES; RELIABILITY; POPULATION; QUESTIONS;
BEHAVIORS; OUTCOMES; SAMPLE; EQ-5D
AB To show that an individual's health-related quality of life (HRQOL) is not determined only by their personal-level characteristics, but also is socially determined by both physical and social environmental characteristics of their communities. This analysis examined the association of selected county-level indicators on respondents' unhealthy days and assessed the utility of mean unhealthy days for US counties as community health indicators. Data came from the 1999-2001 Behavioral Risk Factor Surveillance System. We used multilevel models to calculate the proportion of between-county variation in HRQOL that was explained by county-level contextual variables and examine the causal heterogeneity of some personal-level factors modified by these contextual variables. Counties with worse socioeconomic indicators, high mortality rate, and low life expectancy were associated with higher numbers of unhealthy days. These indicators explained 13-22% variance of county-level physically unhealthy days and 4.5-9.5% variance of county-level mentally unhealthy days. The GINI index, suicide rate, percent uninsured, primary care facilities-to-population ratio, and most county-level demographic and housing indicators also had significant but smaller impact on respondents' unhealthy days. Also, the counties with poorer socioeconomic scores had additional negative HRQOL impact on older persons. This study provides important new empirical information on whether various commonly-measured characteristics of the social environment, which are believed to be social determinants of health, are in fact associated with the perceived physical and mental health of its residents. Our findings provide additional support for the construct validity of county-level HRQOL as a community health indicator.
C1 [Jia, Haomiao] Columbia Univ, Dept Biostat, Mailman Sch Publ Hlth, New York, NY 10032 USA.
[Jia, Haomiao] Columbia Univ, Sch Nursing, New York, NY 10032 USA.
[Moriarty, David G.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Kanarek, Norma] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA.
RP Jia, HM (reprint author), Columbia Univ, Dept Biostat, Mailman Sch Publ Hlth, 617 W 168th St, New York, NY 10032 USA.
EM hj2198@columbia.edu; DMoriarty@cdc.gov; nkanarek@jhsph.edu
NR 52
TC 18
Z9 18
U1 2
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0094-5145
J9 J COMMUN HEALTH
JI J. Community Health
PD OCT
PY 2009
VL 34
IS 5
BP 430
EP 439
DI 10.1007/s10900-009-9173-5
PG 10
WC Health Policy & Services; Public, Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA 494ZR
UT WOS:000269859300010
PM 19554435
ER
PT J
AU Petersen, W
Cobb, K
AF Petersen, Wade
Cobb, Kristin
TI First Record of the Turkestan Cockroach, Blatta lateralis (Walker), in
Georgia (USA)
SO JOURNAL OF ENTOMOLOGICAL SCIENCE
LA English
DT Article
DE invasive pest; Turkestan cockroach; Blatta lateralis
C1 [Petersen, Wade; Cobb, Kristin] Ctr Dis Control & Prevent, Div Parasit Dis, Entomol Branch, Chamblee, GA 30341 USA.
RP Petersen, W (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Entomol Branch, Chamblee, GA 30341 USA.
EM wade.petersen@us.army.mil
NR 0
TC 3
Z9 3
U1 1
U2 7
PU GEORGIA ENTOMOLOGICAL SOC INC
PI TIFTON
PA PO BOX 748 DEPT ENTOMOLOGY COASTAL PLAIN EXPT STATION, TIFTON, GA
31793-0748 USA
SN 0749-8004
J9 J ENTOMOL SCI
JI J. Entomol. Sci.
PD OCT
PY 2009
VL 44
IS 4
BP 415
EP 416
PG 2
WC Entomology
SC Entomology
GA 524HB
UT WOS:000272133300015
ER
PT J
AU Zarate-Bermudez, MA
AF Zarate-Bermudez, Max A.
TI Enhancing the Public Health Perspective on Onsite Wastewater Systems
SO JOURNAL OF ENVIRONMENTAL HEALTH
LA English
DT Editorial Material
ID INDICATOR BACTERIA; QUALITY; CHILDREN; AQUIFER
C1 [Zarate-Bermudez, Max A.] CDC, Environm Hlth Serv Branch, Div Emergency, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Zarate-Bermudez, Max A.] E Carolina Univ, Greenville, NC USA.
RP Zarate-Bermudez, MA (reprint author), CDC, Environm Hlth Serv Branch, Div Emergency, Natl Ctr Environm Hlth, 4770 Buford Highway NE,MS F-60, Atlanta, GA 30341 USA.
EM mzarate-bermudez@cdc.gov
NR 17
TC 2
Z9 2
U1 1
U2 6
PU NATL ENVIRON HEALTH ASSOC
PI DENVER
PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA
SN 0022-0892
J9 J ENVIRON HEALTH
JI J. Environ. Health
PD OCT
PY 2009
VL 72
IS 3
BP 59
EP 61
PG 3
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 502QS
UT WOS:000270475700008
PM 19882992
ER
PT J
AU Freuling, C
Vos, A
Johnson, N
Kaipf, I
Denzinger, A
Neubert, L
Mansfield, K
Hicks, D
Nunez, A
Tordo, N
Rupprecht, CE
Fooks, AR
Muller, T
AF Freuling, C.
Vos, A.
Johnson, N.
Kaipf, I.
Denzinger, A.
Neubert, L.
Mansfield, K.
Hicks, D.
Nunez, A.
Tordo, N.
Rupprecht, C. E.
Fooks, A. R.
Mueller, T.
TI Experimental infection of serotine bats (Eptesicus serotinus) with
European bat lyssavirus type 1a
SO JOURNAL OF GENERAL VIROLOGY
LA English
DT Article
ID RABIES VIRUS; MYOTIS-DAUBENTONII; VIRAL-RNA; PCR ASSAY; FUSCUS;
SUSCEPTIBILITY; GERMANY; SHEEP; TRANSMISSION; PATHOGENESIS
AB The serotine bat (Eptesicus serotinus) accounts for the vast majority of bat rabies cases in Europe and is considered the main reservoir for European bat lyssavirus type 1 (EBLV-1, genotype 5). However, so far the disease has not been investigated in its native host under experimental conditions. To assess viral virulence, dissemination and probable means of transmission, captive bats were infected experimentally with an EBLV-1a virus isolated from a naturally infected conspecific from Germany. Twenty-nine wild caught bats were divided into five groups and inoculated by intracranial (i.c.), intramuscular (i.m.) or subcutaneous (s.c.) injection or by intranasal (i.n.) inoculation to mimic the various potential routes of infection. One group of bats was maintained as uninfected controls. Mortality was highest in the i.c.-infected animals, followed by the s.c. and i.m. groups, Incubation periods varied from 7 to 26 days depending on the route of infection. Rabies did not develop in the i.n. group or in the negative-control group. None of the infected bats seroconverted. Viral antigen was detected in more than 50% of the taste buds of an i.c.-infected animal. Shedding of viable virus was measured by virus isolation in cell culture for one bat from the s.c. group at 13 and 14 days post-inoculation, i.e. 7 days before death. In conclusion, it is postulated that s.c. inoculation, in nature caused by bites, may be an efficient way of transmitting EBLV-1 among free-living serotine bats.
C1 [Freuling, C.; Mueller, T.] Friedrich Loeffler Inst, Fed Res Inst Anim Hlth, Inst Epidemiol, WHO Collaborating Ctr Rabies Surveillance & Res, D-16868 Wusterhausen, Germany.
[Vos, A.; Neubert, L.] IDT Biol GmbH, D-06861 Dessau Rosslau, Germany.
[Johnson, N.; Mansfield, K.; Hicks, D.; Nunez, A.; Fooks, A. R.] Vet Labs Agcy Weybridge, WHO Collaborating Ctr Characterisat Rabies & Rabi, Rabies & Wildlife Zoonoses Grp, Addlestone KT15 3NB, Surrey, England.
[Kaipf, I.; Denzinger, A.] Univ Tubingen, Inst Neurobiol, D-72076 Tubingen, Germany.
[Tordo, N.] Inst Pasteur, Dept Virol, Antiviral Strategy Unit, F-75724 Paris, France.
[Rupprecht, C. E.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Freuling, C (reprint author), Friedrich Loeffler Inst, Fed Res Inst Anim Hlth, Inst Epidemiol, WHO Collaborating Ctr Rabies Surveillance & Res, Seestr 55, D-16868 Wusterhausen, Germany.
EM conrad.freuling@fli.bund.de
RI Johnson, Nicholas/B-4654-2011; Nunez Castel, Alejandro/C-2560-2011;
Hicks, Daniel/C-6700-2011; Mansfield, Karen/D-8399-2011; Fooks,
Anthony/F-5418-2010; APHA, Staff publications/E-6082-2010
OI Johnson, Nicholas/0000-0002-6106-9373;
FU UK Department for Environment, Food and Rural Affairs [SE0524, SE0528];
German Ministry of Nutrition, Agriculture and Consumer Protection
FX The authors would like to acknowledge the technical assistance of
Manuela Wieczorek and Ulrike Bley (IDT Biologika GmbH), Jeannette Kliemt
and Astrid Schameitat (Friedrich-Loeffler-Institute) and Ben Haxton
(Veterinary Laboratories Agency). We also thank Dr Andreas Frohlich
(Friedrich-Loeffler-Institute) for assistance with statistical analysis
and the three anonymous reviewers for their valuable comments on the
manuscript. This project was jointly funded by the UK Department for
Environment, Food and Rural Affairs (Defra grants SE0524 and SE0528) and
by the German Ministry of Nutrition, Agriculture and Consumer
Protection. Use of trade names and commercial Sources are for
identification only and do not imply endorsement by the US Department of
Health and Human Services. The findings and conclusions in this report
are those of the authors and do not necessarily represent the views of
the funding agency.
NR 56
TC 24
Z9 24
U1 1
U2 6
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
BERKS, ENGLAND
SN 0022-1317
J9 J GEN VIROL
JI J. Gen. Virol.
PD OCT
PY 2009
VL 90
BP 2493
EP 2502
DI 10.1099/vir.0.011510-0
PG 10
WC Biotechnology & Applied Microbiology; Virology
SC Biotechnology & Applied Microbiology; Virology
GA 502ZL
UT WOS:000270499700022
PM 19515825
ER
PT J
AU Paz-Bailey, G
Sternberg, M
Puren, AJ
Markowitz, LE
Ballard, R
Delany, S
Hawkes, S
Nwanyanwu, O
Ryan, C
Lewis, DA
AF Paz-Bailey, Gabriela
Sternberg, Maya
Puren, Adrian J.
Markowitz, Lauri E.
Ballard, Ronald
Delany, Sinead
Hawkes, Sarah
Nwanyanwu, Okey
Ryan, Caroline
Lewis, David A.
TI Improvement in Healing and Reduction in HIV Shedding with Episodic
Acyclovir Therapy as Part of Syndromic Management among Men: A
Randomized, Controlled Trial
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article; Proceedings Paper
CT 17th International AIDS Conference
CY AUG 03-08, 2008
CL Mexico City, MEXICO
ID HERPES-SIMPLEX-VIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; RECURRENT GENITAL
HERPES; SEXUALLY-TRANSMITTED-DISEASES; PLACEBO-CONTROLLED TRIAL; TYPE-2
INFECTION; ORAL ACYCLOVIR; DOUBLE-BLIND; SOUTH-AFRICA; RISK-FACTORS
AB Background. It is uncertain whether episodic acyclovir will enhance ulcer healing if delivered at primary health care settings, because there is often a delay in treatment initiation.
Methods. A double-blind, randomized, placebo-controlled trial of 5-day acyclovir (400 mg 3 times daily) was conducted among men with genital ulcers in South Africa. Participants received syndromic management; were tested for ulcer etiology, human immunodeficiency virus (HIV), syphilis, and herpes simplex virus type 2 (HSV-2); and were seen over the course of a month to evaluate ulcer healing and HIV-1 RNA shedding. Outcomes were ulcer duration and HIV-1 RNA shedding, assessed on day 7 among HIV-1-seropositive participants with a herpetic ulcer.
Results. A total of 309 men received acyclovir, and 306 received placebo; 63% were HIV-1 positive. There were 295 HIV-1-positive participants with a herpetic ulcer. Acyclovir improved ulcer healing-61% of those receiving acyclovir healed by day 7, compared with 42% of those receiving placebo (adjusted relative risk, 1.4 [95% confidence interval, 1.1-1.8]; P = .003). Acyclovir also improved healing by a median of 3 days (P = .002) and reduced HIV-1 ulcer shedding on day 7 (24% for acyclovir vs 37% for placebo P = .05).
Conclusions. Addition of acyclovir to syndromic management will improve healing of genital ulcers and may potentially reduce HIV transmission in combination with other interventions.
C1 [Paz-Bailey, Gabriela; Sternberg, Maya; Markowitz, Lauri E.; Ballard, Ronald; Nwanyanwu, Okey; Ryan, Caroline] Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA.
[Lewis, David A.] Univ Witwatersrand, Dept Internal Med, Johannesburg, South Africa.
[Delany, Sinead] Univ Witwatersrand, Reprod Hlth & HIV Res Unit, Johannesburg, South Africa.
[Hawkes, Sarah] London Sch Hyg & Trop Med, London WC1, England.
RP Paz-Bailey, G (reprint author), Univ Valle Guatemala, 18 Ave,11-42 Zona,15 Vista Hermosa 3, Guatemala City, Guatemala.
EM gpaz@gt.cdc.gov
OI Hawkes, Sarah/0000-0003-1062-3538
FU PHS HHS [U62/CCU022901]
NR 45
TC 27
Z9 27
U1 0
U2 1
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 1
PY 2009
VL 200
IS 7
BP 1039
EP 1049
DI 10.1086/605647
PG 11
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 490CN
UT WOS:000269475000005
PM 19715417
ER
PT J
AU Markowitz, LE
Sternberg, M
Dunne, EF
McQuillan, G
Unger, ER
AF Markowitz, Lauri E.
Sternberg, Maya
Dunne, Eileen F.
McQuillan, Geraldine
Unger, Elizabeth R.
TI Seroprevalence of Human Papillomavirus Types 6, 11, 16, and 18 in the
United States: National Health and Nutrition Examination Survey
2003-2004
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID YOUNG-WOMEN; CERVICAL-CANCER; NATURAL-HISTORY; UNIVERSITY-STUDENTS; HPV
INFECTION; RISK-FACTORS; MEN; PREVALENCE; COHORT; SEROEPIDEMIOLOGY
AB Background. Human papillomavirus (HPV) seroprevalence data can help define the epidemiology of this common sexually transmitted pathogen.
Methods. We determined the seroprevalence of HPV types 6, 11, 16, and 18 (HPV types in the quadrivalent vaccine) among 4303 persons aged 14-59 years who participated in the National Health and Nutrition Examination Survey 2003-2004.
Results. The seroprevalences of HPV types 6, 11, 16, and 18 among female subjects were 17.0%, 7.1%, 15.6%, and 6.5%, respectively. Among males, the seroprevalences were lower for each type, with 6.3% observed for HPV-6, 2.0% for HPV-11, 5.1% for HPV-16, and 1.5% for HPV-18 (P < .001 for all comparisons). For any HPV vaccine type, the seroprevalence was 32.5% among females and 12.2% among males; the seroprevalence of any HPV vaccine type increased with age, reaching 42.0% among women aged 30-39 years and 18.0% among men aged 50-59 years. Antibodies to all 4 vaccine types were detected in 0.4% of females and 0% of males. Non-Hispanic blacks had a higher seroprevalence of any HPV vaccine type than that observed for non-Hispanic whites or Mexican Americans. Age and lifetime number of sex partners were factors independently associated with seroprevalence of any HPV vaccine type among both females and males, and poverty level was also a factor among females.
Conclusions. This is the first population-based seroprevalence study in the United States of all 4 HPV types targeted by the quadrivalent vaccine, and its findings can inform vaccine policy.
C1 [Markowitz, Lauri E.] CDC, NCHHSTP, Div STD Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA.
[Unger, Elizabeth R.] CDC, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA.
[McQuillan, Geraldine] CDC, Natl Ctr Hlth Stat, Hyattsville, MD USA.
RP Markowitz, LE (reprint author), CDC, NCHHSTP, Div STD Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, 1600 Clifton Rd,MS E-02, Atlanta, GA 30333 USA.
EM lem2@cdc.gov
OI Unger, Elizabeth/0000-0002-2925-5635
FU Division of STD Prevention; National Centers for HIV; Viral Hepatitis,
STD; TB Prevention; National Center for Health Statistics; Centers for
Disease Control and Prevention
FX Financial support: Division of STD Prevention, National Centers for HIV,
Viral Hepatitis, STD, and TB Prevention, and National Center for Health
Statistics, Centers for Disease Control and Prevention.
NR 48
TC 109
Z9 112
U1 0
U2 3
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 1
PY 2009
VL 200
IS 7
BP 1059
EP 1067
DI 10.1086/604729
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 490CN
UT WOS:000269475000008
PM 19719390
ER
PT J
AU Tian, H
Brimmer, DJ
Lin, JMS
Tumpey, AJ
Reeves, WC
AF Tian, Hao
Brimmer, Dana J.
Lin, Jin-Mann S.
Tumpey, Abbigail J.
Reeves, William C.
TI Web Usage Data as a Means of Evaluating Public Health Messaging and
Outreach
SO JOURNAL OF MEDICAL INTERNET RESEARCH
LA English
DT Article
DE Internet: Web usage mining; chronic fatigue syndrome; public health
campaigns; market basket analysis; Markov chain model; continuing
medical education
ID CHRONIC-FATIGUE-SYNDROME; INFORMATION; INTERNET; MAIL
AB Background: The Internet is increasingly utilized by researchers, health care providers, and the public to seek medical information. The Internet also provides a powerful tool for public health messaging. Understanding the needs of the intended audience and how they use websites is critical for website developers to provide better services to the intended users.
Objective: The aim of the study was to examine the utilization of the chronic fatigue syndrome (CFS) website at the Centers for Disease Control and Prevention (CDC). We evaluated (1) CFS website utilization, (2) outcomes of a CDC CFS public awareness campaign, and (3) user behavior related to public awareness campaign materials and CFS continuing medical education courses.
Methods: To describe and evaluate Web utilization, we collected Web usage data over an 18-month period and extracted page views, visits, referring domains, and geographic locations. We used page views as the primary measure for the CFS awareness outreach effort. We utilized market basket analysis and Markov chain model techniques to describe user behavior related to utilization of campaign materials and continuing medical education courses.
Results: The CDC CFS website received 3,647,736 views from more than 50 countries over the 18-month period and was the 33rd most popular CDC website. States with formal Cl, S programs had higher visiting density, such as Washington, DC; Georgia; and New Jersey. Most visits (71%) were from Web search engines, with 16% from non-search-engine sites and 12% from visitors who had bookmarked the site. The public awareness campaign was associated with a sharp increase and subsequent quick drop in Web traffic. Following the campaign, user interest shifted from information targeting consumer basic knowledge to information for health care professionals. The market basket analysis showed that visitors preferred the 60-second radio clip public service announcement over the 30-second one. Markov chain model results revealed that most visitors took the online continuing education courses in sequential order and were less likely to drop out after they reached the Introduction pages of the courses.
Conclusions: The utilization of the CFS website reflects a high level of interest in the illness by visitors to the site. The high utilization shows the website to be an important online resource for people seeking basic information about CFS and for those looking for professional health care and research information. Public health programs should consider analytic methods to further public health by understanding the characteristics of those seeking information and by evaluating the outcomes of public health campaigns. The website was an effective means to provide health information about CFS and serves as an important public health tool for community outreach.
C1 [Tian, Hao; Brimmer, Dana J.; Lin, Jin-Mann S.; Reeves, William C.] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA.
[Tumpey, Abbigail J.] Ctr Dis Control & Prevent, Off Director, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
RP Tian, H (reprint author), Ctr Dis Control & Prevent, Chron Viral Dis Branch, Div Viral & Rickettsial Dis, 1600 Clifton Rd MS A-15, Atlanta, GA 30333 USA.
EM ejq7@cdc.gov
FU US Centers for Disease Control and Prevention, Atlanta, GA, USA
FX This study was fully funded by the US Centers for Disease Control and
Prevention, Atlanta, GA, USA. The findings and conclusions in this
report are those of the authors and do not necessarily represent the
views of the funding agency.
NR 25
TC 14
Z9 14
U1 2
U2 9
PU JOURNAL MEDICAL INTERNET RESEARCH
PI TORONTO
PA TORONTO GENERAL HOSPITAL, R FRASER ELLIOTT BLDG, 4TH FL, R 4S435, 190
ELIZABETH ST, TORONTO, ON M5G 2C4, CANADA
SN 1438-8871
J9 J MED INTERNET RES
JI J. Med. Internet Res.
PD OCT-DEC
PY 2009
VL 11
IS 4
AR e52
DI 10.2196/jmir.1278
PG 12
WC Health Care Sciences & Services; Medical Informatics
SC Health Care Sciences & Services; Medical Informatics
GA 556YW
UT WOS:000274633000010
PM 20026451
ER
PT J
AU Rota, JS
Turner, JC
Yost-Daljev, MK
Freeman, M
Toney, DM
Meisel, E
Williams, N
Sowers, SB
Lowe, L
Rota, PA
Nicolai, LA
Peake, L
Bellini, WJ
AF Rota, J. S.
Turner, J. C.
Yost-Daljev, M. K.
Freeman, M.
Toney, D. M.
Meisel, E.
Williams, N.
Sowers, S. B.
Lowe, L.
Rota, P. A.
Nicolai, L. A.
Peake, L.
Bellini, W. J.
TI Investigation of a Mumps Outbreak Among University Students With Two
Measles-Mumps-Rubella (MMR) Vaccinations, Virginia, September-December
2006
SO JOURNAL OF MEDICAL VIROLOGY
LA English
DT Article
DE mumps; MMR; vaccine failure; IgG EIA
ID IMMUNOGLOBULIN-G; VACCINE FAILURE; ENZYME IMMUNOASSAYS; YOUNG-ADULTS;
VIRUS; AVIDITY; POPULATION; SPECIMENS; COVERAGE; ASSAY
AB Following the clinical diagnosis of the first case of mumps on September 22,2006 at the University of Virginia (UVA), 52 suspected cases were identified through active surveillance for mumps by the end of December 2006. Samples were collected from 47 students who presented with parotitis despite a documented history of two doses of measles, mumps, and rubella (MMR) vaccine. Six of 47 serum samples (13%) were positive for mumps IgM, and 46/47 specimens were positive for mumps IgG. Endpoint titration of acute phase serum samples from laboratory-confirmed cases did not provide evidence that elevated serum IgG is a consistent marker for infection among cases due to secondary vaccine failure. Buccal swab samples from 39 of the 47 students were tested by real-time reverse transcription-polymerase chain reaction (RT-PCR) and/or viral culture. Mumps virus or mumps RNA was detected in 12 of 39 buccal samples (31%). Genetic analysis of the virus from the outbreak at UVA indicated that the outbreak was not linked to the large mumps outbreak in the Midwestern US that occurred earlier in 2006. Our findings support the use of viral detection to improve laboratory diagnosis of mumps among persons who have received two doses of MMR. J. Med. Virol. 81:1819-1825, 2009. (C) 2009 Wiley-Liss, Inc.
C1 [Rota, J. S.] Ctr Dis Control & Prevent, MMRHLB, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Turner, J. C.] Univ Virginia, Elson Student Hlth Ctr, Charlottesville, VA USA.
[Yost-Daljev, M. K.; Freeman, M.; Toney, D. M.; Meisel, E.] Virginia Div Consolidated Lab Serv, Richmond, VA USA.
[Nicolai, L. A.] Virginia Dept Hlth, Richmond, VA USA.
[Peake, L.] Thomas Jefferson Hlth Dist, Charlottesville, VA USA.
RP Rota, JS (reprint author), Ctr Dis Control & Prevent, MMRHLB, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,M-S C-22, Atlanta, GA 30333 USA.
EM jrota@cdc.gov
NR 22
TC 25
Z9 27
U1 0
U2 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0146-6615
J9 J MED VIROL
JI J. Med. Virol.
PD OCT
PY 2009
VL 81
IS 10
BP 1819
EP 1825
DI 10.1002/jmv.21557
PG 7
WC Virology
SC Virology
GA 489BV
UT WOS:000269395400019
PM 19697404
ER
PT J
AU Shaffer, RE
Rengasamy, S
AF Shaffer, Ronald E.
Rengasamy, Samy
TI Respiratory protection against airborne nanoparticles: a review
SO JOURNAL OF NANOPARTICLE RESEARCH
LA English
DT Article
DE Respirator; Respiratory protection; Filtration; Nanoparticle; EHS;
Occupational safety and health; Aerosols
ID FILTERING-FACEPIECE RESPIRATORS; FILTRATION PERFORMANCE; ULTRAFINE
PARTICLES; AEROSOL-PARTICLES; FIT FACTORS; N95; SIZE; EFFICIENCY;
LEAKAGE; PENETRATION
AB As a precautionary measure, it is often recommended that workers take steps to reduce their exposure to airborne nanoparticles through the use of respiratory protective devices. The purpose of this study was to provide a review and analysis of the research literature and current recommendations on respirators used for protection against nanoparticles. Key research findings were that studies with particles as small as 4 nm have shown that conventional single-fiber filtration theory can be used to describe the filtration performance of respirators and that the most penetrating particle size for respirators equipped with commonly used electrostatic filter media is in the range of 30-100 nm. Future research needs include human laboratory and workplace protection factor studies to measure the respirator total inward leakage of nanoparticles. Industrial hygienists and safety professionals should continue to use traditional respirator selection guidance for workers exposed to nanoparticles.
C1 [Shaffer, Ronald E.; Rengasamy, Samy] NIOSH, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, Pittsburgh, PA 15236 USA.
RP Shaffer, RE (reprint author), NIOSH, Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, 626 Cochrans Mill Rd,Bldg 29,POB 18070, Pittsburgh, PA 15236 USA.
EM RShaffer@cdc.gov
RI Shaffer, Ronald/I-2134-2012
NR 44
TC 40
Z9 41
U1 0
U2 16
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1388-0764
J9 J NANOPART RES
JI J. Nanopart. Res.
PD OCT
PY 2009
VL 11
IS 7
BP 1661
EP 1672
DI 10.1007/s11051-009-9649-3
PG 12
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 503NL
UT WOS:000270543100010
ER
PT J
AU Howard, J
Murashov, V
AF Howard, John
Murashov, Vladimir
TI National nanotechnology partnership to protect workers
SO JOURNAL OF NANOPARTICLE RESEARCH
LA English
DT Article
DE Nanotechnology; Nanomaterials; Occupational safety and health; Health
standards; National partnership; Exposure; EHS
ID CARBON NANOTUBES; EXPOSURE; HEALTH; NANOPARTICLES; IDENTIFICATION;
NANOMATERIALS; INSTILLATION; OPERATIONS; REACTOR; SAFETY
AB Nanotechnology is predicted to improve many aspects of human life. By 2015, it is estimated to represent $3.1 trillion in manufactured goods. Data is emerging that exposure to nanomaterials may pose a health risk to workers. If the economic promise of nanotechnology is to be achieved, ways need to be found to protect nanotechnology workers now. The Occupational Safety and Health Act of 1970 (OSHAct) gave the responsibility to protect workers to the Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH) through research, standards adoption, and standards enforcement. Since 1980, adopting new occupational health standards has grown more complex. The increased complexity has greatly slowed efforts to adopt protective standards for toxic agents that are well-known to pose significant risks. The likelihood of rapidly adopting standards to protect workers from nanomaterials, whose risks are just emerging, seems even more unlikely. Use of the OSHAct's general duty clause to protect workers also seems uncertain at this time. In the interim, a national partnership led by NIOSH involving nanotech manufacturers and downstream users, workers, academic researchers, safety, and health practitioners is proposed. A National Nanotechnology Partnership would generate knowledge about the nature and the extent of worker risk, utilize that knowledge to develop risk control strategies to protect nanotechnology workers now, and provide an evidence base for NIOSH recommendations to OSHA for a nanotechnology program standard at a future date.
C1 [Murashov, Vladimir] NIOSH, Ctr Dis Control & Prevent, US Dept HHS, Washington, DC 20201 USA.
[Howard, John] Ctr Dis Control & Prevent, Publ Hlth Law Program, US Dept HHS, Washington, DC 20201 USA.
RP Murashov, V (reprint author), NIOSH, Ctr Dis Control & Prevent, US Dept HHS, 395 St SW,Suite 9200, Washington, DC 20201 USA.
EM jhoward1@cdc.gov; vmurashov@cdc.gov
RI Murashov, Vladimir/K-5481-2012
NR 62
TC 11
Z9 11
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1388-0764
EI 1572-896X
J9 J NANOPART RES
JI J. Nanopart. Res.
PD OCT
PY 2009
VL 11
IS 7
BP 1673
EP 1683
DI 10.1007/s11051-009-9682-2
PG 11
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 503NL
UT WOS:000270543100011
ER
PT J
AU Park, RM
Bowler, RM
Roels, HA
AF Park, Robert M.
Bowler, Rosemarie M.
Roels, Harry A.
TI Exposure-Response Relationship and Risk Assessment for Cognitive
Deficits in Early Welding-Induced Manganism
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID LONG-TERM EXPOSURE; NERVOUS-SYSTEM; PARKINSONS-DISEASE;
MOVEMENT-DISORDERS; FUME EXPOSURE; NEUROPSYCHOLOGICAL SEQUELAE;
OCCUPATIONAL-EXPOSURE; FERROALLOY WORKERS; NEUROLOGICAL RISK; BRIDGE
WELDERS
AB Objective: The exposure-response relationship for manganese (Mn)-induced adverse nervous system effects is not well described. Symptoms and neuropsychological deficits associated with early manganism, were previously reported for welders constructing bridge piers during 2003 to 2004. A reanalysis using improved exposure, work history information, and diverse exposure metrics is presented here. Methods: Ten neuropsychological performance measures were examined, including working memory index (WMI), verbal intelligence quotient, design fluency, Stroop color word test, Rey-Osterrieth Complex Figure, and Auditory Consonant Trigram tests. AN blood levels and air sampling data in the form of both personal and area samples were available. The exposure metrics used were cumulative exposure to Mn, body burden assuming simple first-order kinetics for Mn elimination, and cumulative burden (effective dose). Benchmark doses were calculated. Results. Burden with a half-life of about 150 days was the best predictor of blood Mn. WMI performance declined by 3.6 (normal = 100, SD = 15),for each 1.0 mg/m(3) X mo exposure (P = 0.02, one toiled). A I the group mean exposure metric (burden; half-life = 275 days), WMI performance was at the lowest 17th percentile of normal, and at the maximum observed metric, performance was at the lowest 2.5 percentiles. Four other outcomes also exhibited statistically significant associations (verbal intelligence quotient, verbal comprehension index, design fluency, Stroop color word test); no dose-rate effect was observed for three of the five outcomes. Conclusions: A risk assessment performed for the five stronger ejects, choosing various percentiles of normal performance to represent impairment, identified benchmark doses for a 2-year exposure leading to 5% excess impairment prevalence in the range of 0.03 to 0.15 mg/m(3) or 30 to 150 mu g/m(3), total Mn in air, levels that are far below those permitted by current More than one-third of workers would be impaired after working 2 years at 0.2 mg/m(3) Mn (the current threshold, limit value). (J Occup Environ Med. 2009;51:1125-1136)
C1 [Park, Robert M.] NIOSH, Ctr Dis Control & Prevent, Educ & Informat Div, Risk Evaluat Branch, Cincinnati, OH 45226 USA.
[Bowler, Rosemarie M.] San Francisco State Univ, Dept Psychol, San Francisco, CA 94132 USA.
[Roels, Harry A.] Univ Catholique Louvain, Toxicol & Occupat Med Unit, B-1200 Brussels, Belgium.
RP Park, RM (reprint author), NIOSH, Ctr Dis Control & Prevent, Educ & Informat Div, Risk Evaluat Branch, MS C-15,4676 Columbia Pkwy, Cincinnati, OH 45226 USA.
EM rhp9@cdc.gov
NR 62
TC 16
Z9 17
U1 2
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD OCT
PY 2009
VL 51
IS 10
BP 1125
EP 1136
DI 10.1097/JOM.0b013e3181bd8114
PG 12
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 506AZ
UT WOS:000270746100003
PM 19786894
ER
PT J
AU Naumann, RB
Dellinger, AM
Anderson, ML
Bonomi, AE
Rivara, FP
Thompson, RS
AF Naumann, Rebecca B.
Dellinger, Ann M.
Anderson, Melissa L.
Bonomi, Amy E.
Rivara, Frederick P.
Thompson, Robert S.
TI Preferred modes of travel among older adults: What factors affect the
choice to walk instead of drive?
SO JOURNAL OF SAFETY RESEARCH
LA English
DT Article
DE Older adults; Elderly; Mobility; Motor vehicle; Physical function;
General health
AB Introduction: There are many factors that influence older adults' travel choices. This paper explores the associations between mode of travel choice for a short trip and older adults' personal characteristics. Methods: This study included 406 drivers over the age of 64 who were enrolled in a large integrated health plan in the United States between 1991 and 2001. Bivariate analyses and generalized linear modeling were used to examine associations between choosing to walk or drive and respondents' self-reported general health, physical and functional abilities, and confidence in walking and driving. Results: Having more confidence in their ability to walk versus drive increased an older adult's likelihood of walking to make a short trip by about 20% (PR = 1.22: 95% Cl: 1.06-1.40), and walking for exercise increased the likelihood by about 50% (PR = 1.53; 95% CI = 1.22-1.91). Reporting fair or poor health decreased the likelihood of walking, as did cutting down on the amount of driving due to a physical problem. Discussion: Factors affecting a person's decision to walk for exercise may not be the same as those that influence their decision to walk as a mode of travel. It is important to understand the barriers to walking for exercise and walking for travel to develop strategies to help older adults meet both their exercise and mobility needs. Impact on Industry: Increasing walking over driving among older adults may require programs that increase confidence in walking and encourage walking for exercise. National Safety Council and Elsevier Ltd. All rights reserved.
C1 [Naumann, Rebecca B.; Dellinger, Ann M.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA.
[Anderson, Melissa L.; Thompson, Robert S.] Grp Hlth Cooperat Puget Sound, Ctr Hlth Studies, Seattle, WA 98101 USA.
[Bonomi, Amy E.] Ohio State Univ, Dept Human Dev & Family Sci, Columbus, OH 43210 USA.
[Rivara, Frederick P.] Haborview Injury Prevent & Res Ctr, Seattle, WA 98104 USA.
RP Naumann, RB (reprint author), 4770 Buford Hwy NE,Mailstop F-62, Atlanta, GA 30341 USA.
EM RNaumann@cdc.gov
NR 9
TC 7
Z9 8
U1 2
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4375
J9 J SAFETY RES
JI J. Saf. Res.
PD OCT
PY 2009
VL 40
IS 5
BP 395
EP 398
DI 10.1016/j.jsr.2009.09.001
PG 4
WC Ergonomics; Public, Environmental & Occupational Health; Social
Sciences, Interdisciplinary; Transportation
SC Engineering; Public, Environmental & Occupational Health; Social
Sciences - Other Topics; Transportation
GA 532PC
UT WOS:000272760900010
PM 19932322
ER
PT J
AU Jones, SE
Brown, KRM
Seabert, DM
Sneed, S
AF Jones, Sherry Everett
Brown, Kelli R. McCormack
Seabert, Denise M.
Sneed, Suzanne
TI Editors' Insights: Reviewing for the Journal of School Health
SO JOURNAL OF SCHOOL HEALTH
LA English
DT Article
C1 [Jones, Sherry Everett] Ctr Dis Control & Prevent, Atlanta, GA 30041 USA.
[Brown, Kelli R. McCormack] Univ Florida, Coll Hlth & Human Performance, Gainesville, FL 32611 USA.
[Seabert, Denise M.] Ball State Univ, Dept Physiol & Hlth Sci, Muncie, IN 47306 USA.
[Sneed, Suzanne] Univ Florida, Dept Hlth Educ & Behav, Gainesville, FL 32611 USA.
RP Jones, SE (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,MS K33, Atlanta, GA 30041 USA.
EM sce2@cdc.gov; kbrown@ufl.edu; dseabert@bsu.edu;
AsstEditorSSneed@hhp.ufl.edu
NR 9
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0022-4391
J9 J SCHOOL HEALTH
JI J. Sch. Health
PD OCT
PY 2009
VL 79
IS 10
BP 441
EP 446
PG 6
WC Education & Educational Research; Education, Scientific Disciplines;
Health Care Sciences & Services; Public, Environmental & Occupational
Health
SC Education & Educational Research; Health Care Sciences & Services;
Public, Environmental & Occupational Health
GA 493NH
UT WOS:000269743300001
ER
PT J
AU Jones, SE
Wheeler, LS
Smith, AM
McManus, T
AF Jones, Sherry Everett
Wheeler, Lani S.
Smith, Alisa M.
McManus, Tim
TI Adherence to National Asthma Education and Prevention Program's "How
Asthma-Friendly Is Your School?" Recommendations
SO JOURNAL OF SCHOOL NURSING
LA English
DT Article
DE asthma; schools; environment
ID EXERCISE-INDUCED ASTHMA; HEALTH POLICIES; CHILDREN; TOBACCO;
ADOLESCENTS; STUDENTS
AB School health policies and programs provide the framework for a safe and supportive environment for students with asthma. School Health Policies and Programs Study 2006 data were examined to assess whether schools nationwide have policies and programs consistent with the "How Asthma-Friendly Is Your School?" checklist from the National Asthma Education and Prevention Program. Adherence to some of the recommendations on the checklist was high. For example, 80% or more of schools allowed students to carry and self-administer asthma medications, and obtained and kept asthma action plans. For other recommendations, however, far fewer schools had the recommended polices or programs; most notably, less than one third of schools had a full-time Registered Nurse. Improvements in many school policies and programs are needed so that students have a safe and supportive school environment to help them control their asthma while away from home.
C1 [Jones, Sherry Everett; McManus, Tim] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Smith, Alisa M.] US EPA, Off Radiat & Indoor Air, Indoor Environm Div, Off Air & Radiat, Washington, DC 20460 USA.
RP Jones, SE (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
NR 46
TC 5
Z9 6
U1 3
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1059-8405
J9 J SCH NURS
JI J. Sch. Nurs.
PD OCT
PY 2009
VL 25
IS 5
BP 382
EP 394
DI 10.1177/1059840509343292
PG 13
WC Nursing
SC Nursing
GA 498LA
UT WOS:000270140400008
PM 19770490
ER
PT J
AU Griffin, SO
Barker, LK
Griffin, PM
Cleveland, JL
Kohn, W
AF Griffin, Susan O.
Barker, Laurie K.
Griffin, Paul M.
Cleveland, Jennifer L.
Kohn, William
TI Oral health needs among adults in the United States with chronic
diseases
SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
LA English
DT Article
DE Caries; edentulism; oral health; chronic disease
ID TYPE-2 DIABETIC-PATIENTS; CORONARY-HEART-DISEASE; QUALITY-OF-LIFE;
PERIODONTAL-DISEASE; GENERAL HEALTH; CARDIOVASCULAR-DISEASE;
RISK-FACTORS; HEPATITIS-C; BEHAVIORS; MELLITUS
AB Background. Oral and dental diseases may be associated with other chronic diseases.
Methods. Using data from the National Health and Nutrition Examination Survey 1999-2004, the authors calculated the prevalence of untreated dental diseases, self-reported poor oral health and the number of missing teeth for adults in the United States who had certain chronic diseases. The authors used multivariate analysis to determine whether these diseases were associated with indicators of dental disease after controlling for common risk factors.
Results. Participants with rheumatoid arthritis, diabetes or a liver condition were twice as likely to have an urgent need for dental treatment as were participants who did not have these diseases. After controlling for common risk factors, the authors found that arthritis, cardiovascular disease, diabetes, emphysema, hepatitis C virus, obesity and stroke still were associated with dental disease.
Conclusions. The authors found a high burden of unmet dental care needs among participants with chronic diseases. This association held in the multivariate analysis, suggesting that some chronic diseases may increase the risk of developing dental disease, decrease utilization of dental care or both.
Clinical Implications. Dental and medical care providers should work together to ensure that adults with chronic diseases receive regular dental care.
C1 [Griffin, Susan O.; Barker, Laurie K.; Cleveland, Jennifer L.] Ctr Dis Control & Prevent, Surveillance Invest & Res Branch, Div Oral Hlth, Chamblee, GA 30341 USA.
[Griffin, Paul M.] Georgia Inst Technol, Stewart Sch Ind & Syst Engn, Atlanta, GA 30332 USA.
RP Griffin, SO (reprint author), Ctr Dis Control & Prevent, Surveillance Invest & Res Branch, Div Oral Hlth, 4770 Buford Highway,Mailstop F10, Chamblee, GA 30341 USA.
EM sig1@cdc.gov
NR 38
TC 42
Z9 43
U1 2
U2 19
PU AMER DENTAL ASSOC
PI CHICAGO
PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA
SN 0002-8177
J9 J AM DENT ASSOC
JI J. Am. Dent. Assoc.
PD OCT
PY 2009
VL 140
IS 10
BP 1266
EP 1274
PG 9
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 502ZI
UT WOS:000270499300018
PM 19797557
ER
PT J
AU Metallinos-Katsaras, E
Sherry, B
Kallio, J
AF Metallinos-Katsaras, Elizabeth
Sherry, Bettylou
Kallio, Jan
TI Food Insecurity Is Associated with Overweight in Children Younger than 5
Years of Age
SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION
LA English
DT Article
ID OBESITY; CHILDHOOD; ADOLESCENTS; PREVALENCE; ADULTHOOD; AMERICAN;
SECURITY; HUNGER
AB Both household food insecurity and childhood overweight are serious public health problems that appear to be paradoxically correlated. This study examines the relationship between overweight and household food insecurity with/without hunger in low-income children participating in the Special Supplemental Nutrition Program for Women, Infants, and Children. Weight, height, and household food insecurity data were collected on 8,493 children ages 1 month to 5 years and analyzed by sex, age groups using logistic regression to model the odds of being overweight (weight for length or body mass index [calculated as kg/m(2)] for age >= 95th percentile) given household food insecurity status, controlling for race/ethnicity and maternal education. Analyses were stratified by age and sex because interaction terms with household food insecurity were significant (P<0.10). In this sample, prevalence of household food insecurity was 30.7% (8.3% with hunger) and 18.4% were overweight. Among girls younger than 2 years of age, household food insecurity was associated with reduced odds of overweight compared with food-secure households (odds ratio=0.65; 95% confidence interval: 0.47 to 0.88); hunger status did not alter this association. Among 2- to 5-year-old girls, there was no overall significant association between household food insecurity and overweight; however, household food insecurity with hunger was positively associated with overweight compared with those from food-secure households (odds ratio=1.49; 95% confidence interval: 1.06 to 2.10). No association between household food insecurity and overweight was found among boys. These findings suggest an association between household food insecurity and overweight prevalence in this low-income population. However, sex and age appear to modify both the magnitude and direction of the association. J Am Diet Assoc. 2009;109:1790-1794.
C1 [Metallinos-Katsaras, Elizabeth] Simmons Coll, Dept Nutr, Sch Hlth Sci, Boston, MA 02115 USA.
[Sherry, Bettylou] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
[Kallio, Jan] Altarum Inst, Portland, ME USA.
[Kallio, Jan] Dept Publ Hlth, Bur Family & Community Hlth, Div Nutr, Nutr Serv, Boston, MA USA.
RP Metallinos-Katsaras, E (reprint author), Simmons Coll, Dept Nutr, Sch Hlth Sci, Boston, MA 02115 USA.
EM metallin@simmons.edu
FU Centers for Disease Control and Prevention; Pediatric Nutrition
Surveillance Systems [U50/CCU113102-1]
FX The Centers for Disease Control and Prevention funded the data
collection, and preliminary analyses for this project titled the 1996
Demonstration Sites for Pregnancy and Pediatric Nutrition Surveillance
Systems (Cooperative Agreement reference number U50/CCU113102-1).
NR 32
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Z9 24
U1 1
U2 16
PU AMER DIETETIC ASSOC
PI CHICAGO
PA 216 W JACKSON BLVD #800, CHICAGO, IL 60606-6995 USA
SN 0002-8223
J9 J AM DIET ASSOC
JI J. Am. Diet. Assoc.
PD OCT
PY 2009
VL 109
IS 10
BP 1790
EP 1794
DI 10.1016/j.jada.2009.07.007
PG 5
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 502YV
UT WOS:000270498000021
PM 19782181
ER
PT J
AU Zhang, XZ
Williams, DE
Beckles, GL
Gregg, EW
Barker, L
Luo, HB
Rutledge, SA
Saaddine, JB
AF Zhang, Xinzhi
Williams, Desmond E.
Beckles, Gloria L.
Gregg, Edward W.
Barker, Lawrence
Luo, Huabin
Rutledge, Stephanie A.
Saaddine, Jinan B.
CA Project DIRECT Evaluation Study Gr
TI Diabetic Retinopathy, Dilated Eye Examination, and Eye Care Education
Among African Americans, 1997 and 2004
SO JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
LA English
DT Article
DE diabetes mellitus; ophthalmic; African Americans
ID HEART HEALTH-PROGRAM; UNITED-STATES; RANDOMIZED-TRIAL; MEDICAL-RECORDS;
US POPULATION; DISEASE RISK; ADULTS; COMMUNITY; PREVALENCE; INTERVENTION
AB Objective: To examine diabetic retinopathy, dilated eye examination, and eye care education among African Americans before and after a community-level public health intervention.
Methods: We analyzed data from Project DIRECT (Diabetes Interventions Reaching and Educating Communities Together) participants with self-reported diabetes (617 in 1996-1997 and 672 in 2003-2004) in Raleigh (intervention community) and Greensboro (comparison community), North Carolina. All analyses were weighted to adjust for the complex sample design of pre and post cross-sectional surveys. Estimates were age standardized to the 2000 US Census population. We used multivariate logistic regression to calculate odds ratios and corresponding 95% confidence intervals.
Results: We found no significant difference in prevalence of diabetic retinopathy between the control and intervention communities (p > .05). However, after adjusting for other confounders, receipt of eye care education (OR, 1.59; 95% CI, 1.19-2.13) was independently associated with receipt of dilated eye examination among African Americans with diabetes. Compared with individuals without diabetic retinopathy, those with diabetic retinopathy were more likely to use eye care services (OR, 1.89; 95% CI, 1.41-2.54).
Conclusions: Diabetic retinopathy is a considerable problem among African American communities. Community intervention efforts, such as comprehensive eye care education, that specifically target improvement in diabetic retinopathy and use of eye care services could help better serve this population.
C1 [Zhang, Xinzhi; Williams, Desmond E.; Beckles, Gloria L.; Gregg, Edward W.; Barker, Lawrence; Rutledge, Stephanie A.; Saaddine, Jinan B.] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Luo, Huabin] Mt Olive Coll, Mt Olive, NC USA.
RP Zhang, XZ (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,NE K-10, Atlanta, GA 30341 USA.
EM xzhang4@cdc.gov
FU Project DIRECT Evaluation Study Group
FX The authors will like to acknowledge the work of the Project DIRECT
Evaluation Study Group.
NR 49
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Z9 6
U1 0
U2 0
PU NATL MED ASSOC
PI WASHINGON
PA 1012 10TH ST, N W, WASHINGON, DC 20001 USA
SN 0027-9684
J9 J NATL MED ASSOC
JI J. Natl. Med. Assoc.
PD OCT
PY 2009
VL 101
IS 10
BP 1015
EP 1021
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA 511XJ
UT WOS:000271204700006
PM 19860301
ER
PT J
AU Burns, CC
Campagnoli, R
Shaw, J
Vincent, A
Jorba, J
Kew, O
AF Burns, Cara C.
Campagnoli, Ray
Shaw, Jing
Vincent, Annelet
Jorba, Jaume
Kew, Olen
TI Genetic Inactivation of Poliovirus Infectivity by Increasing the
Frequencies of CpG and UpA Dinucleotides within and across Synonymous
Capsid Region Codons
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID VACCINE-DERIVED POLIOVIRUS; NEIGHBOR BASE SEQUENCES; STRANDED RNA
VIRUSES; TEMPERATURE SENSITIVITY; DEOXYRIBONUCLEIC ACID; ATTENUATION
PHENOTYPE; ENZYMATIC SYNTHESIS; NONCODING REGION; VIRAL GENOME; USAGE
BIAS
AB Replicative fitness of poliovirus can be modulated systematically by replacement of preferred capsid region codons with synonymous unpreferred codons. To determine the key genetic contributors to fitness reduction, we introduced different sets of synonymous codons into the capsid coding region of an infectious clone derived from the type 2 prototype strain MEF-1. Replicative fitness in HeLa cells, measured by plaque areas and virus yields in single-step growth experiments, decreased sharply with increased frequencies of the dinucleotides CpG (suppressed in higher eukaryotes and most RNA viruses) and UpA (suppressed nearly universally). Replacement of MEF-1 capsid codons with the corresponding codons from another type 2 prototype strain (Lansing), a randomization of MEF-1 synonymous codons, increased the %G+C without increasing CpG, and reductions in the effective number of codons used had much smaller individual effects on fitness. Poliovirus fitness was reduced to the threshold of viability when CpG and UpA dinucleotides were saturated within and across synonymous codons of a capsid region interval representing only similar to 9% of the total genome. Codon replacements were associated with moderate decreases in total virion production but large decreases in the specific infectivities of intact poliovirions and viral RNAs. Replication of codon replacement viruses, but not MEF-1, was temperature sensitive at 39.5 degrees C. Synthesis and processing of viral intracellular proteins were largely unaltered in most codon replacement constructs. Replacement of natural codons with synonymous codons with increased frequencies of CpG and UpA dinucleotides may offer a general approach to the development of attenuated vaccines with well-defined antigenicities and very high genetic stabilities.
C1 [Burns, Cara C.] Ctr Dis Control & Prevent, Polio & Picornavirus Branch, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Burns, CC (reprint author), Ctr Dis Control & Prevent, Polio & Picornavirus Branch, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, G 10,1600 Clifton Rd,NE, Atlanta, GA 30333 USA.
EM CBurns@cdc.gov
NR 71
TC 38
Z9 38
U1 0
U2 5
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD OCT
PY 2009
VL 83
IS 19
BP 9957
EP 9969
DI 10.1128/JVI.00508-09
PG 13
WC Virology
SC Virology
GA 491WX
UT WOS:000269614300030
PM 19605476
ER
PT J
AU Fairley, TL
Pollack, LA
Moore, AR
Smith, JL
AF Fairley, Temeika L.
Pollack, Lori A.
Moore, Angela R.
Smith, Judith Lee
TI Addressing Cancer Survivorship Through Public Health: An Update from the
Centers for Disease Control and Prevention
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID UNITED-STATES
AB Currently, there are nearly 12 million cancer survivors living in the United States. They face a myriad of personal and health issues related to their cancer treatment. Increased recognition of cancer survivorship as a distinct and important phase that follows the diagnosis and treatment of cancer has contributed to the development of public health-related strategies and plans to address those strategies. CDC's Division of Cancer Prevention and Control (DCPC) uses an interdisciplinary public health approach to address the needs of cancer survivors through applied research, public health surveillance and data collection, education, and health promotion, especially among underserved populations that may be at risk for health disparities. Our surveillance activities contribute to population-based descriptions of the health and treatment experiences of cancer survivors in the United States. These data inform applied research activities as well as provide baseline data on cancer survivors for local comprehensive cancer control programs. The knowledge gained by our research efforts informs the development of interventions, awareness and education campaigns, and other outreach activities targeting cancer survivors and those who care for and support them. Our partnerships with national organizations, state health agencies, and other key groups are essential in the development, implementation, and promotion of effective cancer control practices related to cancer survivorship. This article provides an overview of the cancer survivorship activities currently being implemented by DCPC. We highlight several public health surveillance, research, and programmatic outreach and partnership activities currently underway.
C1 [Fairley, Temeika L.; Pollack, Lori A.; Moore, Angela R.; Smith, Judith Lee] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30341 USA.
RP Fairley, TL (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Highway,NE K-57, Atlanta, GA 30341 USA.
EM tfairley@cdc.gov
FU DCPC Cancer Survivorship Inter-branch Group
FX We thank the members of the DCPC Cancer Survivorship Inter-branch Group:
Donatus Ekwueme, Ph. D., Nikki Hawkins, Ph. D., Genise V. Nixon, Sun H.
Rim, M. P. H., Juan Rodriguez, M. P. H., Susan Sabatino, M. D.,
George-Ann Townsend, Katrina F. Trivers, Ph. D., and Hannah Weir, Ph.
D., for their contributions to CDC's efforts in cancer survivorship.
NR 18
TC 14
Z9 14
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD OCT
PY 2009
VL 18
IS 10
BP 1525
EP 1531
DI 10.1089/jwh.2009.1666
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Obstetrics & Gynecology; Women's Studies
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Obstetrics & Gynecology; Women's Studies
GA 512FJ
UT WOS:000271231200091
PM 19788367
ER
PT J
AU Aponte, JJ
Schellenberg, D
Egan, A
Breckenridge, A
Carneiro, I
Critchley, J
Danquah, I
Dodoo, A
Kobbe, R
Lell, B
May, J
Premji, Z
Sanz, S
Sevene, E
Soulaymani-Becheikh, R
Winstanley, P
Adjei, S
Anemana, S
Chandramohan, D
Issifou, S
Mockenhaupt, F
Owusu-Agyei, S
Greenwood, B
Grobusch, MP
Kremsner, PG
Macete, E
Mshinda, H
Newman, RD
Slutsker, L
Tanner, M
Alonso, P
Menendez, C
AF Aponte, John J.
Schellenberg, David
Egan, Andrea
Breckenridge, Alasdair
Carneiro, Ilona
Critchley, Julia
Danquah, Ina
Dodoo, Alexander
Kobbe, Robin
Lell, Bertrand
May, Juergen
Premji, Zul
Sanz, Sergi
Sevene, Esperanza
Soulaymani-Becheikh, Rachida
Winstanley, Peter
Adjei, Samuel
Anemana, Sylvester
Chandramohan, Daniel
Issifou, Saadou
Mockenhaupt, Frank
Owusu-Agyei, Seth
Greenwood, Brian
Grobusch, Martin P.
Kremsner, Peter G.
Macete, Eusebio
Mshinda, Hassan
Newman, Robert D.
Slutsker, Laurence
Tanner, Marcel
Alonso, Pedro
Menendez, Clara
TI Efficacy and safety of intermittent preventive treatment with
sulfadoxine-pyrimethamine for malaria in African infants: a pooled
analysis of six randomised, placebo-controlled trials
SO LANCET
LA English
DT Article
ID PLASMODIUM-FALCIPARUM MALARIA; TANZANIAN INFANTS; DOUBLE-BLIND;
ANTIMALARIAL TREATMENT; IRON SUPPLEMENTATION; ROUTINE VACCINATIONS;
SENEGALESE CHILDREN; MOZAMBICAN INFANTS; DRUG-RESISTANCE; ANEMIA CONTROL
AB Background Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa.
Methods We pooled data from six double-blind, randomised, placebo-controlled trials (undertaken one each in Tanzania, Mozambique, and Gabon, and three in Ghana) that assessed the efficacy of IPTi with sulfadoxine-pyrimethamine. In all trials, IPTi or placebo was given to infants at the time of routine vaccinations delivered by WHO's Expanded Program on Immunization. Data from the trials for incidence of clinical malaria, risk of anaemia (packed-cell volume <25% or haemoglobin <80 g/L), and incidence of hospital admissions and adverse events in infants up to 12 months of age were reanalysed by use of standard outcome definitions and time periods. Analysis was by modified intention to treat, including all infants who received at least one dose of IPTi or placebo.
Findings The six trials provided data for 7930 infants (IPTi, n=3958; placebo, n=3972). IPTi had a protective efficacy of 30.3% (95% CI 19.8-39.4, p<0.0001) against clinical malaria, 21.3% (8.2-32.5, p=0.002) against the risk of anaemia, 38.1% (12.5-56.2, p=0.007) against hospital admissions associated with malaria parasitaemia, and 22.9% (10.0-34.0, p=0.001) against all-cause hospital admissions. There were 56 deaths in the IPTi group compared with 53 in the placebo group (rate ratio 1.05, 95% Cl 0.72-1.54, p=0.79). One death, judged as possibly related to IPTi because it occurred 19 days after a treatment dose, was subsequently attributed to probable sepsis. Four of 676 non-fatal hospital admissions in the IPTi group were deemed related to study treatment compared with five of 860 in the placebo group. None of three serious dermatological adverse events in the IPTi group were judged related to study treatment compared with one of 13 in the placebo group.
Interpretation IPTi with sulfadoxine-pyrimethamine was safe and efficacious across a range of malaria transmission settings, suggesting that this intervention is a useful contribution to malaria control.
C1 [Tanner, Marcel] Swiss Trop Inst, CH-4002 Basel, Switzerland.
[Aponte, John J.; Egan, Andrea; Sanz, Sergi; Alonso, Pedro; Menendez, Clara] Univ Barcelona, Hosp Clin, Barcelona Ctr Int Hlth Res, Barcelona, Spain.
[Schellenberg, David; Carneiro, Ilona; Chandramohan, Daniel; Greenwood, Brian] London Sch Hyg & Trop Med, London WC1, England.
[Breckenridge, Alasdair] Med & Healthcare Prod Regulatory Agcy, London, England.
[Critchley, Julia] Newcastle Univ, Inst Hlth & Soc, Adv Res Chron Dis Epidemiol ARCHEPI Programme, Sch Populat & Hlth Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Danquah, Ina; Mockenhaupt, Frank] Charite, Inst Trop Med & Int Hlth, D-13353 Berlin, Germany.
[Dodoo, Alexander] Univ Ghana, Sch Med, Korle Bu Teaching Hosp, Ctr Trop Clin Pharmacol & Therapeut, Accra, Ghana.
[Kobbe, Robin; May, Juergen] Bernhard Nocht Inst Trop Med, Res Grp Infect Dis Epidemiol, Hamburg, Germany.
[Lell, Bertrand; Issifou, Saadou; Kremsner, Peter G.] Univ Tubingen, Dept Parasitol, Inst Trop Med, Tubingen, Germany.
[Lell, Bertrand; Issifou, Saadou; Grobusch, Martin P.; Kremsner, Peter G.] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon.
[Premji, Zul] Muhimbili Univ, Coll Hlth Sci, Dept Parasitol Med Entomol, Sch Publ Hlth & Social Sci, Dar Es Salaam, Tanzania.
[Sevene, Esperanza] Eduardo Mondlane Univ, Fac Med, Dept Pharmacol, Maputo, Mozambique.
[Soulaymani-Becheikh, Rachida] Ctr Antipoisons & Pharmacovigilance Maroc, Rabat, Morocco.
[Winstanley, Peter] Univ Liverpool, Sch Clin Sci, Liverpool L69 3BX, Merseyside, England.
[Adjei, Samuel] Minist Hlth, Ghana Hlth Serv, Agona, Ashanti Region, Ghana.
[Anemana, Sylvester] Minist Hlth, Ghana Hlth Serv, Secondi Takoradi, Western Region, Ghana.
[Owusu-Agyei, Seth] Minist Hlth, Ghana Hlth Serv, Kintampo Hlth Res Ctr, Kintampo, Ghana.
[Grobusch, Martin P.] Univ Witwatersrand, Infect Dis Unit, Div Clin Microbiol & Infect Dis, NHLS, Johannesburg, South Africa.
[Grobusch, Martin P.] Univ Witwatersrand, Fac Hlth Sci, Johannesburg, South Africa.
[Macete, Eusebio; Alonso, Pedro] Ctr Invest Saude Manhica, Manhica, Mozambique.
[Mshinda, Hassan] Ifakara Hlth Res Dev Ctr, Ifakara, Tanzania.
[Newman, Robert D.; Slutsker, Laurence] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Tanner, M (reprint author), Swiss Trop Inst, Socinstr 57,POB 4002, CH-4002 Basel, Switzerland.
EM marcel.tanner@unibas.ch
RI May, Jurgen/E-7857-2011;
OI Danquah, Ina/0000-0003-3222-3498
FU Bill & Melinda Gates Foundation
FX Funding Bill & Melinda Gates Foundation.
NR 50
TC 121
Z9 122
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
J9 LANCET
JI Lancet
PD OCT-NOV
PY 2009
VL 374
IS 9700
BP 1533
EP 1542
DI 10.1016/S0140-6736(09)61258-7
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA 517CS
UT WOS:000271591300032
PM 19765816
ER
PT J
AU Steer, AC
Law, I
Matatolu, L
Beall, BW
Carapetis, JR
AF Steer, Andrew C.
Law, Irwin
Matatolu, Laisiana
Beall, Bernard W.
Carapetis, Jonathan R.
TI Global emm type distribution of group A streptococci: systematic review
and implications for vaccine development
SO LANCET INFECTIOUS DISEASES
LA English
DT Review
ID ACUTE RHEUMATIC-FEVER; PNEUMOCOCCAL SEROGROUPS; SEQUENCE TYPES;
UNITED-STATES; INFECTION; DISEASE; SKIN; IMMUNOGENICITY; EPIDEMIOLOGY;
FORMULATION
AB emm sequence typing is the most widely used method for defining group A streptococcal (GAS) strains, and has been applied to isolates in all regions of the world. We did a systematic review of the global distribution of GAS emm types. 102 articles and reports were included (38081 isolates). Epidemiological data from high-income countries were predominant, with sparse data from low-income countries. The epidemiology of GAS disease in Africa and the Pacific region seems to be different from that in other regions, particularly high-income countries. In Africa and the Pacific, there were no dominant emm types, a higher diversity of emm types, and many of the common emm types in other parts of the world were less common (including emm1, 4, 6, and 12). Our data have implications for the development of GAS vaccines. On the basis of the available data, the current formulation of the experimental multivalent emm vaccine would provide good coverage in high-income countries, particularly USA, Canada, and Europe, but poor coverage in Africa and the Pacific, and only average coverage in Asia and the Middle East.
C1 [Steer, Andrew C.] Univ Melbourne, Dept Paediat, Ctr Int Child Hlth, Parkville, Vic 3052, Australia.
[Matatolu, Laisiana] Minist Hlth, Fiji Grp Streptococcal Project A, Suva, Fiji.
[Beall, Bernard W.] Ctr Dis Control & Prevent, Streptococcus Lab, Resp Dis Branch, Atlanta, GA USA.
[Carapetis, Jonathan R.] Charles Darwin Univ, Darwin, NT 0909, Australia.
[Carapetis, Jonathan R.] Menzies Sch Hlth Res, Darwin, NT, Australia.
RP Steer, AC (reprint author), Univ Melbourne, Dept Paediat, Ctr Int Child Hlth, Flemington Rd, Parkville, Vic 3052, Australia.
EM andrew.steer@rch.org.au
RI Nosik, Alexandra/H-1999-2014
OI Nosik, Alexandra/0000-0002-7852-1784
NR 41
TC 201
Z9 203
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1473-3099
J9 LANCET INFECT DIS
JI Lancet Infect. Dis.
PD OCT
PY 2009
VL 9
IS 10
BP 611
EP 616
PG 6
WC Infectious Diseases
SC Infectious Diseases
GA 506KK
UT WOS:000270773500016
PM 19778763
ER
PT J
AU Scarboro, S
Hertel, N
Burgett, E
Howell, R
Ansari, A
AF Scarboro, Sarah
Hertel, Nolan
Burgett, Eric
Howell, Rebecca
Ansari, Armin
TI VALIDATION OF MONTE CARLO SIMULATION OF A THYROID UPTAKE SYSTEM USING
VARIOUS SOURCES AND A SLAB PHANTOM
SO NUCLEAR TECHNOLOGY
LA English
DT Article; Proceedings Paper
CT 11th International Conference on Radiation Shielding/15th Topical
Meeting of the Radiation-Protection-and-Shielding-Division
CY APR 13-18, 2008
CL Pine Mt, GA
SP Radiat Protect & Shielding Div
DE thyroid uptake system; radiological dispersal device; internal
contamination
AB In the event of a terrorist act involving a radiological agent, internal contamination due to inhalation is a potential health threat. When a large population is potentially impacted, there is need for methodology to serve as an initial screening or triage tool to rapidly identify individuals with significant amounts of internal contamination and to assist in prioritizing collection of large numbers of bioassay samples needed in such an incident. Common handheld radiation detectors and medical devices are tools that can effectively and rapidly screen a large number of people for internal contamination due to gamma-emitting isotopes. This work investigated the use of a common medical device, a thyroid uptake system or thyroid probe, in screening for internal contamination in individuals. The response of a thyroid uptake system in such a situation can be estimated by using a validated Monte Carlo model of the thyroid uptake system and various human phantoms. A computational model of the thyroid uptake system was built using the Los Alamos Particle Transport Code, MCNP Version 5. The validation of this computational model was demonstrated by comparisons to a series of benchmark measurements using the actual device and six isotopes with a range of gamma-ay emission energies.
C1 [Scarboro, Sarah; Hertel, Nolan; Burgett, Eric] Georgia Inst Technol, Atlanta, GA 30332 USA.
[Howell, Rebecca] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Ansari, Armin] Ctr Dis Control & Prevent, Radiat Studies Branch, Atlanta, GA USA.
RP Scarboro, S (reprint author), Georgia Inst Technol, 900 Atlantic Dr, Atlanta, GA 30332 USA.
EM sarah.scarboro@gmail.com
NR 4
TC 2
Z9 2
U1 0
U2 1
PU AMER NUCLEAR SOC
PI LA GRANGE PK
PA 555 N KENSINGTON AVE, LA GRANGE PK, IL 60526 USA
SN 0029-5450
J9 NUCL TECHNOL
JI Nucl. Technol.
PD OCT
PY 2009
VL 168
IS 1
BP 169
EP 172
PG 4
WC Nuclear Science & Technology
SC Nuclear Science & Technology
GA 501XL
UT WOS:000270417700030
ER
PT J
AU Samuel-Hodge, CD
Johnston, LF
Gizlice, Z
Garcia, BA
Lindsley, SC
Bramble, KP
Hardy, TE
Ammerman, AS
Poindexter, PA
Will, JC
Keyserling, TC
AF Samuel-Hodge, Carmen D.
Johnston, Larry F.
Gizlice, Ziya
Garcia, Beverly A.
Lindsley, Sara C.
Bramble, Kathy P.
Hardy, Trisha E.
Ammerman, Alice S.
Poindexter, Patricia A.
Will, Julie C.
Keyserling, Thomas C.
TI Randomized Trial of a Behavioral Weight Loss Intervention for Low-income
Women: The Weight Wise Program
SO OBESITY
LA English
DT Article
ID AFRICAN-AMERICAN WOMEN; DIABETES-PREVENTION-PROGRAM; LIFE-STYLE
INTERVENTION; DIET QUALITY INDEX; BLOOD-PRESSURE; PHYSICAL-ACTIVITY;
CLINICAL-TRIAL; DISEASE RISK; ADULTS; COMMUNITY
AB Low-income women in the United States have the highest rates of obesity, yet they are seldom included in weight loss trials. To address this research gap, components of two evidence-based weight loss interventions were adapted to create a 16-week intervention for low-income women (Weight Wise Program), which was evaluated in a randomized trial with the primary outcome of weight loss at 5-month follow-up. Participants were low-income women (40-64 years) with a BMI of 25-45. Of 143 participants, 72 were randomized to the Weight Wise Program (WWP) and 71 to the Control Group (CG). Five-month follow-up data were obtained from 64 (89%) WWP and 62 (87%) CG participants. With baseline values carried forward for missing data, WWP participants had a weight change of -3.7 kg compared to 0.7 kg in the CG (4.4 kg difference, 95% confidence interval (CI), 3.2-5.5, P < 0.001). For systolic blood pressure (SBP), change in the WWP was -6.5 mm Hg compared to -0.4 mm Hg among controls (6.2 mm Hg difference, 95% CI, 1.7-10.6, P = 0.007); for diastolic BP (DBP), changes were -4.1 mm Hg for WWP compared to -1.3 mm Hg for controls (2.8 mm Hg difference, 95% CI, 0.0-5.5, P = 0.05). Of the 72 WWP participants, 64, 47, and 19% lost at least 3, 5, and 7% of their initial body weight, respectively. In conclusion, the WWP was associated with statistically significant and clinically important short-term weight loss.
C1 [Samuel-Hodge, Carmen D.; Poindexter, Patricia A.] Univ N Carolina, Sch Med, Dept Nutr, Chapel Hill, NC 27599 USA.
[Samuel-Hodge, Carmen D.; Ammerman, Alice S.] Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA.
[Samuel-Hodge, Carmen D.; Johnston, Larry F.; Gizlice, Ziya; Garcia, Beverly A.; Lindsley, Sara C.; Bramble, Kathy P.; Hardy, Trisha E.; Ammerman, Alice S.; Keyserling, Thomas C.] Univ N Carolina, Ctr Hlth Promot & Dis Prevent, Chapel Hill, NC USA.
[Poindexter, Patricia A.; Will, Julie C.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA USA.
[Keyserling, Thomas C.] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC USA.
RP Samuel-Hodge, CD (reprint author), Univ N Carolina, Sch Med, Dept Nutr, Chapel Hill, NC 27599 USA.
EM carmen_samuel@unc.edu
FU centers of Disease control and Prevention (CDC) [U48/CCU422824-04,
U48/DP000059]; NIH [DK56350]; University of North Carolina Prevention
Research center [U48/DP000059]
FX This study was conducted through partnerships among the UNC center of
Health Promotion and Disease Prevention, the North Carolina Department
of Health and Human Services, the New Hanover community Health center,
and Grace United Methodist church. We are indebted to all the agency
partners, study staff, and the women of the Weight Wise Program, whose
involvement made this study possible. trial registration:
ClinicalTrials.gov Identifier: NCT00288301. Funding/Support: this study
was supported through funding by centers of Disease control and
Prevention (CDC) cooperative Agreement Number U48/CCU422824-04. Other
support was provided by the University of North Carolina Nutrition
Epidemiology core through funding by NIH Grant DK56350 and by the
University of North Carolina Prevention Research center (U48/DP000059
for Health Promotion and Disease Prevention) through funding by CDC
cooperative Agreement Number U48/DP000059.
NR 43
TC 24
Z9 24
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD OCT
PY 2009
VL 17
IS 10
BP 1891
EP 1899
DI 10.1038/oby.2009.128
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 502UD
UT WOS:000270484800013
PM 19407810
ER
PT J
AU Yuan, BZ
Chapman, J
Reynolds, SH
AF Yuan, B-Z
Chapman, J.
Reynolds, S. H.
TI Proteasome inhibitors induce apoptosis in human lung cancer cells
through a positive feedback mechanism and the subsequent Mcl-1 protein
cleavage
SO ONCOGENE
LA English
DT Article
DE proteasome inhibitor; non-small cell lung carcinoma; apoptosis; Mcl-1;
positive feedback mechanism; protein cleavage
ID TRAIL-INDUCED APOPTOSIS; CARCINOMA CELLS; DEATH; MITOCHONDRIA;
SENSITIZE; EPIDEMIOLOGY; ACTIVATION; BORTEZOMIB; THERAPY; TARGETS
AB Proteasome inhibitors (PIs) are promising new therapeutic agents for treating non-small cell lung carcinoma (NSCLC). To investigate the mechanisms of action of PIs, we analyzed the proapoptotic activities of PIs (MG132 or Bortezomib) in NSCLC cells. We found that both MG132 (>1 mu M) and Bortezomib (>0.025 mu M) induced a significant apoptosis in NCI-H1703, a PI-sensitive NSCLC cell line, through initially activating the intrinsic apoptosis pathway, leading to the activation of a positive feedback mechanism (PFM), which then conveyed apoptosis signaling from the intrinsic pathway to the extrinsic pathway with formation of a signaling loop for maximal caspase activation. Mcl-1 and Noxa were identified to be the major anti-apoptotic and proapoptotic proteins, respectively, in PI-induced apoptosis and mutually exclusive in protein stability. Although the Mcl-1 protein was upregulated by proteasome inhibition, it was also subjected to caspase 3-dependent cleavage governed by the PFM. Moreover, it was revealed that Mcl-1 protein cleavage contributed to PFM-governed apoptosis in following inter-related ways: reducing the anti-apoptotic Mcl-1; generating the truncated proapoptotic Mcl-1(S); and inducing a shift of balance between Mcl-1 and Noxa. It was further manifested that tumor necrosis factor-related apoptosis-inducing ligand boosted MG132's proapoptotic activity through strengthening the PFM in both NCI-H1703 and NCI-H358, a PI-resistant NSCLC cell line. Therefore, this study provides a basis for enhancing the efficacy of PIs in treating NSCLC. Oncogene (2009) 28, 3775-3786; doi:10.1038/onc.2009.240; published online 17 August 2009
C1 [Yuan, B-Z; Chapman, J.; Reynolds, S. H.] NIOSH, Mol Genet Lab, Toxicol & Mol Biol Branch, CDC, Morgantown, WV 26505 USA.
RP Yuan, BZ (reprint author), NIOSH, Mol Genet Lab, Toxicol & Mol Biol Branch, CDC, 1095 Willowdale Rd,M-S L-3014, Morgantown, WV 26505 USA.
EM bby1@cdc.gov
NR 34
TC 16
Z9 17
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0950-9232
J9 ONCOGENE
JI Oncogene
PD OCT
PY 2009
VL 28
IS 43
BP 3775
EP 3786
DI 10.1038/onc.2009.240
PG 12
WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
Heredity
SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics &
Heredity
GA 512KT
UT WOS:000271248400002
PM 19684616
ER
PT J
AU Fonseca-Gonzalez, I
Cardenas, R
Quinones, ML
McAllister, J
Brogdon, WG
AF Fonseca-Gonzalez, Idalyd
Cardenas, Rocio
Quinones, Martha L.
McAllister, Janet
Brogdon, William G.
TI Pyrethroid and organophosphates resistance in Anopheles (N.) nuneztovari
Gabaldn populations from malaria endemic areas in Colombia
SO PARASITOLOGY RESEARCH
LA English
DT Article
ID MOSQUITO PROTEIN MICROASSAY; GLUTATHIONE-S-TRANSFERASE; INSECTICIDE
RESISTANCE; KNOCKDOWN RESISTANCE; MICROPLATE ASSAY; CYTOCHROMES P450;
ELEVATED OXIDASE; SMALL PORTIONS; VECTORS; ALBIMANUS
AB Field populations of Colombian malaria vector Anopheles (N.) nuneztovari were studied using World Health Organization (WHO) and Center for Disease Control and Prevention (CDC) bioassay techniques and through the use of biochemical microplate-based assays for resistance enzymes. Insecticides evaluated included the pyrethroids lambda-cyhalothrin and deltamethrin, organophosphates malathion and fenitrothion, and the organochlorine dichlorodiphenyltrichloroethane (DDT). Study sites selected were based upon malaria incidence, vector presence, and control activities in Colombia. Early stage selection for reduced susceptibility was observed in the bioassays for some locations. Data from the WHO and CDC bioassay methods were broadly consistent, with some differences noted. Evidence is presented for low-level initial selection of some resistance mechanisms such as mixed-function oxidases and modified acetylcholinesterase. Data from the site Encharcazn implies that selection for DDT-pyrethroid cross-resistance has occurred, though not likely at a level that currently threatens vector control by either class of insecticides, and further implies that knockdown resistance (kdr) may be present in those populations. Further studies using synergists and development of a kdr-specific assay for A. nuneztovari thus become priorities. The resistance levels to lambda-cyhalothrin and deltamethrin found in the Encharcazn population are of concern since these two insecticides are currently used for both indoor spraying and treated nets. In addition, the resistance to fenitrothion, the indoor spray insecticide mostly used for this species due to their exophilic behavior, found in the El Zulia population, makes urgent to find alternatives for chemical control in these areas. These data provide the initial baselines for insecticide susceptibility profiles for A. nuneztovari in Colombia and the first report of insecticide resistance in this vector.
C1 [Fonseca-Gonzalez, Idalyd] Univ Antioquia, Inst Biol, Grp Biol & Control Enfermedades Infecciosas, Medellin, Colombia.
[Cardenas, Rocio] Inst Dept Salud, Subgrp Control Vectores, Cucuta, Colombia.
[Quinones, Martha L.] Univ Nacl Colombia, Fac Med, Dept Salud Publ, Bogota, Colombia.
[McAllister, Janet] Ctr Dis Control & Prevent, Ft Collins, CO USA.
[Brogdon, William G.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Fonseca-Gonzalez, I (reprint author), Univ Antioquia, Inst Biol, Grp Biol & Control Enfermedades Infecciosas, Lab 620,Carrera 53 61-30, Medellin, Colombia.
EM idalyd.fonseca@siu.udea.edu.co; rocicardenas@gmail.com;
mlquinonesp@unal.edu.co; jvm6@cdc.gov; wgb1@cdc.gov
FU Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnologia
[22290416444]; Comite de Investigacion CODI, Universidad de Antioquia
FX This work was financed by the Instituto Colombiano para el Desarrollo de
la Ciencia y la Tecnologia "Francisco Jose de Caldas" COLCIENCIAS (Grant
number 22290416444) and Comite de Investigacion CODI, Universidad de
Antioquia. Idalyd Fonseca-Gonzalez obtained financial support for her
doctoral training from COLCIENCIAS.
NR 52
TC 16
Z9 17
U1 2
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0932-0113
EI 1432-1955
J9 PARASITOL RES
JI Parasitol. Res.
PD OCT
PY 2009
VL 105
IS 5
BP 1399
EP 1409
DI 10.1007/s00436-009-1570-2
PG 11
WC Parasitology
SC Parasitology
GA 495SH
UT WOS:000269914800028
PM 19655174
ER
PT J
AU Mvundura, M
Amendah, D
Kavanagh, PL
Sprinz, PG
Grosse, SD
AF Mvundura, Mercy
Amendah, Djesika
Kavanagh, Patricia L.
Sprinz, Philippa G.
Grosse, Scott D.
TI Health Care Utilization and Expenditures for Privately and Publicly
Insured Children With Sickle Cell Disease in the United States
SO PEDIATRIC BLOOD & CANCER
LA English
DT Article
DE medical expenditure; sickle cell disease; utilization
ID MANAGED CARE; ANEMIA; COSTS; PROPHYLAXIS; MEDICAID; SERVICES; THERAPY
AB Background There are no current national estimates on health care utilization and expenditures for US children with sickle cell disease (SCD). Procedure. We used the MarketScan (R) Medicaid Database and the MarketScan (R) Commercial Claims and Encounters Database for 2005 to estimate health services use and expenditures. The final samples consisted of 2,428 Medicaid-enrolled and 621 privately insured children with SCD. Results. The percentage of children with SCD enrolled in Medicaid with an inpatient admission was higher compared to those privately insured (439% vs. 38%), yet mean expenditures per admission were 35% lower ($6,469 vs. $10,013). The mean number of emergency department (ED) visits was 49% higher for Medicaid-enrolled children compared to those with private insurance (1.36 vs. 0.91), but mean expenditures per ED visit were 28% lower. The mean number of non-ED outpatient visits was similar (12.6 vs. 11.5) but mean expenditures were 40% lower for the Medicaid-enrolled children ($3,557 vs. $5,908). The mean expenditures on drug claims were higher among those with Medicaid than private insurance ($1,049 vs. $531). Mean total expenditures for children with SCD enrolled in Medicaid were 25% lower than for privately insured children ($11,075 vs. $14,722). The samples were comparable with respect to SCD-related inpatient discharge diagnoses and use of outpatient blood transfusions. Conclusions. Children with SCD enrolled in Medicaid had lower expenditures than privately insured children, despite higher utilization of medical care, which indicates lower average reimbursements. Research is needed to assess the quality of care delivered to Medicaid-enrolled children with SCD and its relation to health outcomes. Pediatr Blood Cancer 2009;53: 642-646. Published 2009 Wiley-Liss, Inc.
C1 [Mvundura, Mercy] Ctr Dis Control & Prevent, Off Publ Hlth Gen, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Amendah, Djesika; Grosse, Scott D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30341 USA.
[Kavanagh, Patricia L.; Sprinz, Philippa G.] Boston Univ, Sch Med, Dept Pediat, Boston, MA 02118 USA.
[Kavanagh, Patricia L.; Sprinz, Philippa G.] Boston Med Ctr, Boston, MA USA.
RP Mvundura, M (reprint author), Ctr Dis Control & Prevent, Off Publ Hlth Gen, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,NE,Mailstop K-89, Atlanta, GA 30341 USA.
EM mmvundura@cdc.gov
OI Kavanagh, Patricia/0000-0002-3312-1576; Mvundura,
Mercy/0000-0002-7711-9558
FU Centers for Disease Control and Prevention
FX The findings and conclusions in this report are those of the authors and
do not necessarily represent the official position of the Centers for
Disease Control and Prevention.
NR 19
TC 35
Z9 35
U1 1
U2 7
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1545-5009
J9 PEDIATR BLOOD CANCER
JI Pediatr. Blood Cancer
PD OCT
PY 2009
VL 53
IS 4
BP 642
EP 646
DI 10.1002/pbc.22069
PG 5
WC Oncology; Hematology; Pediatrics
SC Oncology; Hematology; Pediatrics
GA 487SJ
UT WOS:000269295500023
PM 19492318
ER
PT J
AU Cortes, JE
Curns, AT
Tate, JE
Parashar, UD
AF Cortes, Jennifer E.
Curns, Aaron T.
Tate, Jacqueline E.
Parashar, Umesh D.
TI Trends in Healthcare Utilization for Diarrhea and Rotavirus Disease in
Privately Insured US Children < 5 Years of Age, 2001-2006
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
DE gastroenteritis; rotavirus; vaccine; disease burden
ID UNITED-STATES; COST-EFFECTIVENESS; HOSPITALIZATIONS; GASTROENTERITIS;
SURVEILLANCE; EPIDEMIOLOGY; VACCINATION; POPULATION; IMPACT
AB Background: To assess impact of the new US rotavirus immunization program initiated in 2006, robust baseline data on diarrhea and rotavirus disease burden are needed. While several studies have assessed burden in inpatient settings, few data are available for emergency department (ED) and outpatient settings.
Methods: We used the MarketScan databases, a large claims-based data repository, to analyze the health and economic burden of diarrhea-related healthcare encounters in children <5 years in inpatient, ED, and outpatient settings from 2001 to 2006. Because rotavirus testing and coding are not routinely performed, rotavirus burden was estimated by calculating excess diarrhea events during winter compared with summer baseline (winter residual method).
Results: Between 2001 and 2006, the average annual rate of healthcare utilization for diarrhea was 1561 per 10,000 children <5 years, with a hospitalization rate of 50 per 10,000, ED visit rate of 180 per 10,000, and outpatient visit rate of 1332 per 10,000. The winter residual method attributed 53% of inpatient, 41% of ED, and 23% of outpatient diarrhea events to rotavirus. By age 5, we estimated that I in 74 children are admitted, I in 27 require ED care, and I in 7 are treated in outpatient settings for rotavirus illness. Median payments for rotavirus in inpatient, ED, and outpatient settings were $3135, $332, and $90, respectively.
Conclusions: Rotavirus causes substantial health and economic burden in US children, especially in ED and outpatient settings. Future monitoring through claims-based data sources should allow assessment of rotavirus vaccine impact on healthcare utilization for diarrhea.
C1 [Cortes, Jennifer E.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30329 USA.
[Cortes, Jennifer E.] Off Workforce & Career Dev, Epidem Intelligence Serv, Atlanta, GA USA.
RP Cortes, JE (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, 1600 Clifton Rd,MS A-47, Atlanta, GA 30329 USA.
EM hgi9@cdc.gov
FU NCI NIH HHS [P30 CA016672]
NR 20
TC 10
Z9 11
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0891-3668
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD OCT
PY 2009
VL 28
IS 10
BP 874
EP 878
DI 10.1097/INF.0b013e3181a653cd
PG 5
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA 501UI
UT WOS:000270407800004
PM 19590460
ER
PT J
AU Ouyang, L
Grosse, SD
Amendah, DD
Schechter, MS
AF Ouyang, Lijing
Grosse, Scott D.
Amendah, Djesika D.
Schechter, Michael S.
TI Healthcare Expenditures for Privately Insured People With Cystic
Fibrosis
SO PEDIATRIC PULMONOLOGY
LA English
DT Article
DE cystic fibrosis; expenditures; complications; cost
ID CHILDREN; POPULATION; ADULTS; COSTS
AB With improved survival and new therapies for people with cystic fibrosis (CF), updated information on medical care expenditures for those individuals is needed. We estimated medical care expenditures, including both insurance reimbursements and patient out-of-pocket expenses, for privately insured people with CF and investigated how those expenditures varied with certain complications of CF From a private insurance claims database of people covered by health plans associated with large corporate employers, we identified people with CF who were currently receiving medical care for the disorder and characterized their medical expenditures during the period 2004-2006. We selected a matching group of people who did not have CF based on age, sex, and geographic area, and calculated incremental expenditures associated with CF We also examined the effect of age and certain complications of CF on these expenditures. The annual medical care expenditure for a person with actively managed CF averaged $48,098 in 2006 dollars, which was 22 times higher than for a person without CF This ratio is high relative to other chronic disorders. Outpatient prescription medications made up the largest component of total expenditures for people with CF (39%). Those who were recorded in claims data as having a liver or lung transplant, malnutrition, diabetes, or a chronic Pseudomonas aeruginosa pulmonary infection incurred much higher expenditures than people without these conditions. People with CF will incur high medical expenditures throughout their lifespan. These findings will assist in the development of economic evaluations of future CF screening and management initiatives. Pediatr Pulmonol. 2009; 44:989-996. 2009 (C) Wiley-Liss, Inc.
C1 [Ouyang, Lijing; Grosse, Scott D.; Amendah, Djesika D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Schechter, Michael S.] Emory Univ, Emory Cyst Fibrosis Ctr, Atlanta, GA 30322 USA.
RP Ouyang, L (reprint author), 1600 Clifton Rd NE,Mail Stop E-88, Atlanta, GA 30333 USA.
EM louyang@cdc.gov
NR 17
TC 23
Z9 23
U1 1
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 8755-6863
EI 1099-0496
J9 PEDIATR PULM
JI Pediatr. Pulmonol.
PD OCT
PY 2009
VL 44
IS 10
BP 989
EP 996
DI 10.1002/ppul.21090
PG 8
WC Pediatrics; Respiratory System
SC Pediatrics; Respiratory System
GA 505OJ
UT WOS:000270703200006
PM 19768806
ER
PT J
AU Bocchini, JA
Bernstein, HH
Bradley, JS
Brady, MT
Byington, CL
Fisher, MC
Glode, MP
Jackson, MA
Keyserling, HL
Kimberlin, DW
Orenstein, WA
Schutze, GE
Willoughby, RE
Dennehy, PH
Frenck, RW
Rubin, LG
Bell, B
Bortolussi, R
Clover, RD
Fischer, MA
Gellin, B
Gorman, RL
Pratt, RD
Lee, L
Read, JS
Starke, JR
Swanson, J
Baker, CJ
Long, SS
Pickering, LK
Ledbetter, EO
Meissner, HC
O'Dell, JD
Weinberg, ST
Frantz, J
AF Bocchini, Joseph A., Jr.
Bernstein, Henry H.
Bradley, John S.
Brady, Michael T.
Byington, Carrie L.
Fisher, Margaret C.
Glode, Mary P.
Jackson, Mary Anne
Keyserling, Harry L.
Kimberlin, David W.
Orenstein, Walter A.
Schutze, Gordon E.
Willoughby, Rodney E.
Dennehy, Penelope H.
Frenck, Robert W., Jr.
Rubin, Lorry G.
Bell, Beth
Bortolussi, Robert
Clover, Richard D.
Fischer, Marc A.
Gellin, Bruce
Gorman, Richard L.
Pratt, R. Douglas
Lee, Lucia
Read, Jennifer S.
Starke, Jeffrey R.
Swanson, Jack
Baker, Carol J.
Long, Sarah S.
Pickering, Larry K.
Ledbetter, Edgar O.
Meissner, H. Cody
O'Dell, J. Dennis
Weinberg, Stuart T.
Frantz, Jennifer
CA Comm Infect Dis
TI Policy Statement-Recommendations for the Prevention and Treatment of
Influenza in Children, 2009-2010
SO PEDIATRICS
LA English
DT Article
DE influenza; novel influenza A (H1N1) virus; immunization; live-attenuated
influenza vaccine; trivalent inactivated influenza vaccine; vaccine;
children; pediatrics
ID INFECTIOUS-DISEASES
AB The purpose of this statement is to update current recommendations for routine use of trivalent seasonal influenza vaccine and antiviral medications for the prevention and treatment of influenza in children. Pediatrics 2009; 124: 1216-1226
C1 [Bell, Beth; Fischer, Marc A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Bortolussi, Robert] Canadian Paediat Soc, Ottawa, ON, Canada.
[Clover, Richard D.] Amer Acad Family Phys, Leawood, KS USA.
[Gorman, Richard L.; Read, Jennifer S.] NIH, Bethesda, MD USA.
[Pratt, R. Douglas; Lee, Lucia] US FDA, Rockville, MD 20857 USA.
EM jfrantz@aap.org
OI Dennehy, Penelope/0000-0002-2259-5370; Byington,
Carrie/0000-0002-7350-9495
NR 5
TC 24
Z9 24
U1 0
U2 0
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD OCT
PY 2009
VL 124
IS 4
BP 1216
EP 1226
DI 10.1542/peds.2009-1806
PG 11
WC Pediatrics
SC Pediatrics
GA 500CI
UT WOS:000270274300028
ER
PT J
AU Krug, SE
Bojko, T
Fein, JA
Fitzmaurice, LS
Frush, KS
Hampers, LC
O'Malley, PJ
Sapien, RE
Sirbaugh, PE
Tenenbein, M
Yamamoto, LG
Brown, K
Johnson, RW
Barata, IA
Benjamin, LS
Bundy, L
Callahan, JM
Cantor, RM
Colletti, JE
Cordle, RJ
Dietrich, AM
Herman, MI
Holtzman, DK
Hostetler, MA
Ishimine, P
Joseph, M
Litell, JM
Markenson, DS
Mehta, S
Muniz, AE
Ojo, A
Pillow, MT
Schwartz, GR
Sharieff, GQ
Sharieff, GQ
Johnson, RW
Barata, IA
Benjamin, LS
Brown, K
Brown, LA
Burbulys, DB
Callahan, JM
Chan, C
Colletti, JE
Cordle, RJ
Finkler, JH
Herman, MI
Holtzman, DK
Hernandez, DA
Hostetler, MA
Ishimine, P
Mace, SE
McCollough, MD
Sacchetti, AD
Schwartz, GR
Bolick, BN
Caten, L
Lozano, K
Marshall, C
Stevens, N
Papa, A
Gausche-Hill, M
Krug, SE
Blum, F
Bullock, K
Burt, CW
Chamberlain, J
Foltin, GL
Frush, K
Johnson, R
Kavanaugh, D
Middleton, K
Sharieff, G
Sacchetti, A
Snow, SK
Wiebe, RA
Wright, JL
AF Krug, Steven E.
Bojko, Thomas
Fein, Joel A.
Fitzmaurice, Laura S.
Frush, Karen S.
Hampers, Louis C.
O'Malley, Patricia J.
Sapien, Robert E.
Sirbaugh, Paul E.
Tenenbein, Milton
Yamamoto, Loren G.
Brown, Kathleen
Johnson, Ramon W.
Barata, Isabel A.
Benjamin, Lee S.
Bundy, Lisa
Callahan, James M.
Cantor, Richard M.
Colletti, James E.
Cordle, Randolph J.
Dietrich, Ann Marie
Herman, Martin I.
Holtzman, Douglas K.
Hostetler, Mark A.
Ishimine, Paul
Joseph, Madeline
Litell, John M.
Markenson, David S.
Mehta, Sanjay
Muniz, Antonio E.
Ojo, Aderonke
Pillow, Malford T.
Schwartz, Gerald R.
Sharieff, Ghazala Q.
Sharieff, Ghazala Q.
Johnson, Ramon W.
Barata, Isabel A.
Benjamin, Lee S.
Brown, Kathleen
Brown, Lance A.
Burbulys, David B.
Callahan, James M.
Chan, Cindy
Colletti, James E.
Cordle, Randolph J.
Finkler, Joseph H.
Herman, Martin I.
Holtzman, Douglas K.
Hernandez, Dennis A.
Hostetler, Mark A.
Ishimine, Paul
Mace, Sharon E.
McCollough, Maureen D.
Sacchetti, Alfred D.
Schwartz, Gerald R.
Bolick, Beth N.
Caten, Liesel
Lozano, Kathleen
Marshall, Christine
Stevens, Nancy
Papa, AnnMarie
Gausche-Hill, Marianne
Krug, Steven E.
Blum, Frederick
Bullock, Kim
Burt, Catherine W.
Chamberlain, James
Foltin, George L.
Frush, Karen
Johnson, Ramon
Kavanaugh, Dan
Middleton, Kimberly
Sharieff, Ghazala
Sacchetti, Al
Snow, Sally K.
Wiebe, Robert A.
Wright, Joseph L.
CA Amer Acad Pediat
Comm Pediat Emergency Med
Amer Coll Emergency Phys
Pediat Comm
Emergency Nurses Assoc
Pediat Comm
TI Joint Policy Statement-Guidelines for Care of Children in the Emergency
Department
SO PEDIATRICS
LA English
DT Article
DE pediatric emergency preparedness
ID PEDIATRIC-PATIENTS; PREPAREDNESS; SEDATION; DEATH
AB Children who require emergency care have unique needs, especially when emergencies are serious or life-threatening. The majority of ill and injured children are brought to community hospital emergency departments (EDs) by virtue of their geography within communities. Similarly, emergency medical services (EMS) agencies provide the bulk of out-of-hospital emergency care to children. It is imperative, therefore, that all hospital EDs have the appropriate resources (medications, equipment, policies, and education) and staff to provide effective emergency care for children. This statement outlines resources necessary to ensure that hospital EDs stand ready to care for children of all ages, from neonates to adolescents. These guidelines are consistent with the recommendations of the Institute of Medicine's report on the future of emergency care in the United States health system. Although resources within emergency and trauma care systems vary locally, regionally, and nationally, it is essential that hospital ED staff and administrators and EMS systems' administrators and medical directors seek to meet or exceed these guidelines in efforts to optimize the emergency care of children they serve. This statement has been endorsed by the Academic Pediatric Association, American Academy of Family Physicians, American Academy of Physician Assistants, American College of Osteopathic Emergency Physicians, American College of Surgeons, American Heart Association, American Medical Association, American Pediatric Surgical Association, Brain Injury Association of America, Child Health Corporation of America, Children's National Medical Center, Family Voices, National Association of Children's Hospitals and Related Institutions, National Association of EMS Physicians, National Association of Emergency Medical Technicians, National Association of State EMS Officials, National Committee for Quality Assurance, National PTA, Safe Kids USA, Society of Trauma Nurses, Society for Academic Emergency Medicine, and The Joint Commission. Pediatrics 2009; 124: 1233-1243
C1 [Gausche-Hill, Marianne; Blum, Frederick; Johnson, Ramon; Sharieff, Ghazala; Sacchetti, Al] Amer Coll Emergency Phys, Philadelphia, PA USA.
[Krug, Steven E.; Chamberlain, James; Foltin, George L.; Frush, Karen; Wiebe, Robert A.] Amer Acad Pediat, Elk Grove Village, IL USA.
[Bullock, Kim] Amer Acad Family Phys, Leawood, KS USA.
[Burt, Catherine W.; Middleton, Kimberly] Ctr Dis Control, Atlanta, GA 30333 USA.
[Snow, Sally K.] Emergency Nurses Assoc, Des Plaines, IL USA.
RI eshaghian, azam/Q-8826-2016
OI eshaghian, azam/0000-0001-7918-2895
FU US Department of Health and Human Services; Health Resources and
Services Administration's Maternal and Child Health Bureau [U93MC00184];
Emergency Medical Services for Children National Resource Center at
Children's National Medical Center [U07MC09174]
FX Development of this statement was supported by the US Department of
Health and Human Services, Health Resources and Services
Administration's Maternal and Child Health Bureau, Partnership for
Information and Communication Project (U93MC00184) and the Emergency
Medical Services for Children National Resource Center at Children's
National Medical Center (U07MC09174). The statement is also consistent
with recommendations of the Institute of Medicine's report on the future
of emergency care in the US health system.
NR 44
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Z9 50
U1 0
U2 3
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD OCT
PY 2009
VL 124
IS 4
BP 1233
EP 1243
DI 10.1542/peds.2009-1807
PG 11
WC Pediatrics
SC Pediatrics
GA 500CI
UT WOS:000270274300030
ER
PT J
AU Bartick, M
Stuebe, A
Shealy, KR
Walker, M
Grummer-Strawn, LM
AF Bartick, Melissa
Stuebe, Alison
Shealy, Katherine R.
Walker, Marsha
Grummer-Strawn, Laurence M.
TI Closing the Quality Gap: Promoting Evidence-Based Breastfeeding Care in
the Hospital
SO PEDIATRICS
LA English
DT Article
DE breastfeeding; hospitals; maternity; health care quality; quality
indicators; quality improvement; health care; infant; newborn
ID BABY-FRIENDLY HOSPITALS; UNITED-STATES; OF-INTEREST; 1ST YEAR; FORMULA;
DURATION; IMPROVEMENT; INDUSTRY; PROPOSAL; CENTERS
AB Evidence shows that hospital-based practices affect breastfeeding duration and exclusivity throughout the first year of life. However, a 2007 CDC survey of US maternity facilities documented poor adherence with evidence-based practice. Of a possible score of 100 points, the average hospital scored only 63 with great regional disparities. Inappropriate provision and promotion of infant formula were common, despite evidence that such practices reduce breastfeeding success. Twenty-four percent of facilities reported regularly giving non-breast milk supplements to more than half of all healthy, full-term infants. Metrics available for measuring quality of breastfeeding care, range from comprehensive Baby-Friendly Hospital Certification to compliance with individual steps such as the rate of in-hospital exclusive breastfeeding. Other approaches to improving quality of breastfeeding care include ( 1) education of hospital decision-makers (eg, through publications, seminars, professional organization statements, benchmark reports to hospitals, and national grassroots campaigns), ( 2) recognition of excellence, such as through Baby-Friendly hospital designation, ( 3) oversight by accrediting organizations such as the Joint Commission or state hospital authorities, ( 4) public reporting of indicators of the quality of breastfeeding care, ( 5) pay-for-performance incentives, in which Medicaid or other third-party payers provide additional financial compensation to individual hospitals that meet certain quality standards, and ( 6) regional collaboratives, in which staff from different hospitals work together to learn from each other and meet quality improvement goals at their home institutions. Such efforts, as well as strong central leadership, could affect both initiation and duration of breastfeeding, with substantial, lasting benefits for maternal and child health. Pediatrics 2009; 124: e793-e802
C1 [Bartick, Melissa] Harvard Univ, Sch Med, Dept Med, Boston, MA USA.
[Bartick, Melissa] Harvard Univ, Sch Med, Dept Med, Cambridge Hlth Alliance, Cambridge, MA 02139 USA.
[Stuebe, Alison] Univ N Carolina, Sch Med, Dept Obstet & Gynecol, Div Maternal & Fetal Med, Chapel Hill, NC USA.
[Shealy, Katherine R.; Grummer-Strawn, Laurence M.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA.
[Walker, Marsha] Natl Alliance Breastfeeding Advocacy, Weston, MA USA.
RP Bartick, M (reprint author), Harvard Univ, Sch Med, Dept Med, Cambridge Hlth Alliance, 1493 Cambridge St, Cambridge, MA 02139 USA.
EM melissabartick@gmail.com
NR 57
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U1 0
U2 13
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD OCT
PY 2009
VL 124
IS 4
BP E793
EP E802
DI 10.1542/peds.2009-0430
PG 10
WC Pediatrics
SC Pediatrics
GA 500CI
UT WOS:000270274300064
PM 19752082
ER
PT J
AU Singleton, RJ
Wirsing, EA
Haberling, DL
Christensen, KY
Paddock, CD
Hilinski, JA
Stoll, BJ
Holman, RC
AF Singleton, Rosalyn J.
Wirsing, Elisabeth A.
Haberling, Dana L.
Christensen, Krista Y.
Paddock, Christopher D.
Hilinski, Joseph A.
Stoll, Barbara J.
Holman, Robert C.
TI Risk Factors for Lower Respiratory Tract Infection Death Among Infants
in the United States, 1999-2004
SO PEDIATRICS
LA English
DT Article
DE infants; lower respiratory tract infection; respiratory; death;
mortality; epidemiology; American Indian; Alaska Native; low birth
weight; pneumonia; bronchiolitis; race
ID ALASKA NATIVE CHILDREN; SYNCYTIAL VIRUS; AMERICAN-INDIANS; MORTALITY;
HOSPITALIZATIONS; HEALTH; TRENDS; POPULATION; ILLNESSES
AB OBJECTIVE: To describe maternal and birth-related risk factors associated with lower respiratory tract infection (LRTI) deaths among infants.
METHODS: Records for infants with LRTI as a cause of death were examined by using the linked birth/infant death database for 1999-2004. Singleton infants dying with LRTI and a random sample of surviving singleton infants were compared for selected characteristics.
RESULTS: A total of 5420 LRTI-associated infant deaths were documented in the United States during 1999-2004, for an LRTI-associated infant mortality rate of 22.3 per 100 000 live births. Rates varied according to race; the rate for American Indian/Alaska Native (AI/AN) infants was highest (53.2), followed by black (44.1), white (18.7), and Asian/Pacific Islander infants (12.3). Singleton infants with low birth weight (< 2500 g) were at increased risk of dying with LRTI after controlling for other characteristics, especially black infants. Both AI/AN and black infants born with a birth weight of < 2500 g were more likely to have died with LRTI than other infants of the same birth weight. Other risk factors associated with LRTI infant death included male gender, the third or more live birth, an Apgar score of < 8, unmarried mother, mother with < 12 years of education, mother < 25 years of age, and mother using tobacco during pregnancy.
CONCLUSIONS: Low birth weight was associated with markedly increased risk for LRTI-associated death among all of the racial groups. Among infants with a birth weight of >= 2500 g, AI/AN and black infants were at higher risk of LRTI-associated death, even after controlling for maternal and birth-related factors. Additional studies and strategies should focus on the prevention of maternal and birth-related risk factors for postneonatal LRTI and on identifying additional risk factors that contribute to elevated mortality among AI/AN and black infants. Pediatrics 2009; 124: e768-e776
C1 [Singleton, Rosalyn J.] Ctr Dis Control & Prevent, Arctic Invest Program, Natl Ctr Preparedness Detect & Control Infect Dis, Coordinating Ctr Infect Dis,US Dept Hlth & Human, Anchorage, AK 99508 USA.
[Singleton, Rosalyn J.] Alaska Native Tribal Hlth Consortium, Anchorage, AK USA.
[Wirsing, Elisabeth A.; Haberling, Dana L.; Christensen, Krista Y.; Paddock, Christopher D.; Holman, Robert C.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Coordinating Ctr Infect Dis,US Dept Hlth & Human, Atlanta, GA USA.
[Hilinski, Joseph A.; Stoll, Barbara J.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA.
RP Singleton, RJ (reprint author), Ctr Dis Control & Prevent, Arctic Invest Program, Natl Ctr Preparedness Detect & Control Infect Dis, Coordinating Ctr Infect Dis,US Dept Hlth & Human, 4055 Tudor Ctr Dr, Anchorage, AK 99508 USA.
EM ris2@cdc.gov
NR 42
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U1 4
U2 8
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD OCT
PY 2009
VL 124
IS 4
BP E768
EP E776
DI 10.1542/peds.2009-0109
PG 9
WC Pediatrics
SC Pediatrics
GA 500CI
UT WOS:000270274300061
PM 19786437
ER
PT J
AU Dorsey, RR
Eberhardt, MS
Gregg, EW
Geiss, LS
AF Dorsey, Rashida R.
Eberhardt, Mark S.
Gregg, Edward W.
Geiss, Linda S.
TI Control of Risk Factors Among People With Diagnosed Diabetes, by Lower
Extremity Disease Status
SO PREVENTING CHRONIC DISEASE
LA English
DT Article
AB Introduction
We examined the control of modifiable risk factors among a national sample of diabetic people with and without lower extremity disease (LED).
Methods
The sample from the 1999-2004 National Health and Nutrition Examination Survey consisted of 948 adults aged 40 years or older with diagnosed diabetes and who had been assessed for LED. LED was defined as peripheral arterial disease (ankle-brachial index <0.9), peripheral neuropathy (>= 1 insensate area), or presence of foot ulcer. Good control of modifiable risk factors, based on American Diabetes Association recommendations, included being a nonsmoker and having the following measurements: hemoglobin A1c (HbA1c) less than 7%, systolic blood pressure less than or equal to 130 mm Hg, diastolic blood pressure less than or equal to 80 mm Hg, high-density lipoprotein (HDL) cholesterol greater than 50 mg/dL, and body mass index (BMI) between 18.5 kg/m(2) and 24.9 kg/m(2).
Results
Diabetic people with LED were less likely than were people without LED to have recommended levels of HbA1c (39.3% vs 53.5%) and HDL cholesterol (29.7% vs 41.1%), but there were no differences in systolic or diastolic blood pressure, BMI classification, or smoking status between people with and without LED. Control of some risk factors differed among population subgroups. Notably, among diabetic people with LED, non-Hispanic blacks were more likely to have improper control of HbA1c (adjusted odds ratio [AOR] = 2.0; 95% confidence interval [CI], 1.1-3.9), systolic blood pressure (AOR = 1.9; 95% CI, 1.1-3.2), and diastolic blood pressure (AOR = 2.6; 95% CI, 1.1-5.8), compared with non-Hispanic whites.
Conclusion
Control of 2 of 6 modifiable risk factors was worse in diabetic adults with LED compared with diabetic adults without LED. Among diabetic people with LED, non-Hispanic blacks had worse control of 3 of 6 risk factors compared with non-Hispanic whites.
C1 [Dorsey, Rashida R.] Ctr Dis Control & Prevent CDC, Epidem Intelligence Serv, Atlanta, GA USA.
[Dorsey, Rashida R.; Eberhardt, Mark S.] Ctr Dis Control & Prevent CDC, Natl Ctr Hlth Stat, Hyattsville, MD USA.
[Gregg, Edward W.; Geiss, Linda S.] CDC, Div Diabet Translat, Atlanta, GA USA.
RP Dorsey, RR (reprint author), 200 Independence Ave,SW,Rm 446F 7, Washington, DC 20201 USA.
EM rrdorsey@gmail.com
NR 30
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Z9 3
U1 1
U2 2
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD OCT
PY 2009
VL 6
IS 4
AR A114
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA V20RY
UT WOS:000208158300004
PM 19754990
ER
PT J
AU Friedman, C
AF Friedman, Carol
TI The Promise of Comprehensive Cancer Control
SO PREVENTING CHRONIC DISEASE
LA English
DT Editorial Material
C1 Natl Ctr Immunizat & Resp Dis, Immunizat Serv Div, Atlanta, GA 30333 USA.
RP Friedman, C (reprint author), Natl Ctr Immunizat & Resp Dis, Immunizat Serv Div, 1600 Clifton Rd,Mailstop E 52, Atlanta, GA 30333 USA.
EM cxf7@cdc.gov
NR 8
TC 0
Z9 0
U1 0
U2 0
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD OCT
PY 2009
VL 6
IS 4
AR A111
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA V20RY
UT WOS:000208158300001
PM 19754987
ER
PT J
AU Jenkins, TM
Chapman, KL
Harshbarger, DS
Townsend, JS
AF Jenkins, Todd M.
Chapman, Kathryn L.
Harshbarger, Dorothy S.
Townsend, Julie S.
TI Hospice Use Among Cancer Decedents in Alabama, 2002-2005
SO PREVENTING CHRONIC DISEASE
LA English
DT Article
AB Introduction
Most studies that describe hospice use among cancer patients use the Surveillance, Epidemiology, and End Results (SEER)-Medicare database, which has known limitations. We used vital records data to describe patterns of hospice use among cancer decedents in Alabama.
Methods
To ascertain hospice use, we linked death certificates from 2002 through 2005 for people who died from cancer to listings of deaths reported by hospices. To evaluate accessibility of care, we calculated straight-line distances between decedent residence at death and the hospice providing care. We used these distances to estimate the reach of each hospice and identify the number of hospice nonusers residing in these areas.
Results
During the study period, 52.0% of cancer decedents in Alabama received hospice care from 165 hospices. Nearly two-thirds of Alabama counties contain at least 1 hospice. Whites (53.6%) used hospice at a significantly higher rate than blacks (47.0%), but the rate of use was similar for women (53.2%) and men (51.0%). For people who were eligible for Medicare, 53.0% received hospice care. The median distance between decedent's residence and the hospice providing care was 9.8 miles. This distance was slightly shorter for blacks than whites and roughly equal by sex.
Conclusion
Alabamians use hospice at lower rates than observed elsewhere. Barriers to hospice care in Alabama must be identified and addressed.
C1 [Chapman, Kathryn L.; Harshbarger, Dorothy S.] Alabama Dept Publ Hlth, Montgomery, AL 36104 USA.
[Jenkins, Todd M.] Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH USA.
[Townsend, Julie S.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Chapman, KL (reprint author), Alabama Dept Publ Hlth, 201 Monroe St,Ste 1478, Montgomery, AL 36104 USA.
EM kchapman@adph.state.al.us
FU Centers for Disease Control and Prevention [U55/CCU421939-05]
FX Funding for this project was provided by a cooperative agreement with
the Centers for Disease Control and Prevention (U55/CCU421939-05).
NR 25
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Z9 2
U1 0
U2 0
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD OCT
PY 2009
VL 6
IS 4
AR A119
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA V20RY
UT WOS:000208158300009
PM 19754995
ER
PT J
AU Major, A
Stewart, SL
AF Major, Anne
Stewart, Sherri L.
TI Celebrating 10 Years of the National Comprehensive Cancer Control
Program, 1998 to 2008
SO PREVENTING CHRONIC DISEASE
LA English
DT Article
C1 [Major, Anne] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30341 USA.
RP Major, A (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Hwy NE,Mailstop K-57, Atlanta, GA 30341 USA.
EM acs0@cdc.gov
NR 14
TC 10
Z9 10
U1 0
U2 0
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD OCT
PY 2009
VL 6
IS 4
AR A133
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA V20RY
UT WOS:000208158300023
PM 19755009
ER
PT J
AU Townsend, JS
Richardson, LC
Steele, CB
White, DE
AF Townsend, Julie S.
Richardson, Lisa C.
Steele, C. Brooke
White, Dana E.
TI Evidence-Based Interventions and Screening Recommendations for
Colorectal Cancer in Comprehensive Cancer Control Plans: A Content
Analysis
SO PREVENTING CHRONIC DISEASE
LA English
DT Article
AB Introduction
Colorectal cancer is the third most commonly diagnosed cancer and third leading cause of cancer death in the United States. The extent to which Comprehensive Cancer Control (CCC) programs in states, tribal governments and organizations, territories, and Pacific Island jurisdictions address evidence-based recommendations and interventions for colorectal cancer in their CCC plans is largely unknown.
Methods
We downloaded CCC plans posted on the Cancer Control PLANET Web site for review. We searched the plans for key terms, identifying potential evidence-based content surrounding colorectal cancer prevention and early detection. Content was abstracted for further review and classification.
Results
Of 55 plans reviewed, 54 (98%) referred to evidence-based recommendations or interventions for colorectal cancer or indicated they intended to refer to the evidence base when developing programs. More than 57% (n = 31) of programs referred to the American Cancer Society guidelines, 41% (n = 22) referred to the United States Preventive Services Task Force, and 11% (n = 6) referred to the Guide to Community Preventive Services. Few programs mentioned Research Tested Intervention Programs (n = 1), National Cancer Institute's Physician Data Query (n = 4), Cochrane Reviews (n = 2), or Put Prevention Into Practice (n = 2) in reference to evidence-based interventions for colorectal cancer prevention.
Conclusion
Most CCC programs discussed either evidence-based screening guidelines or interventions in their cancer plans, although many mentioned this information exclusively as background information. We recommend that program planners be trained to locate evidence-based interventions and use consistent common language to describe them in their plans. CCC program planners should be encouraged to conduct and publish intervention studies.
C1 [Townsend, Julie S.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
RP Townsend, JS (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,NE,Mail Stop K-57, Atlanta, GA 30341 USA.
EM jtownsend@cdc.gov
NR 37
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U1 0
U2 0
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD OCT
PY 2009
VL 6
IS 4
AR A127
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA V20RY
UT WOS:000208158300017
PM 19755003
ER
PT J
AU Williams, D
Kaufman, R
Hayden, J
Robinson, M
Tai, E
AF Williams, Donna
Kaufman, Randi
Hayden, Jennifer
Robinson, Melody
Tai, Eric
TI Comprehensive Cancer Control in the Eye of Hurricane Katrina
SO PREVENTING CHRONIC DISEASE
LA English
DT Letter
C1 [Williams, Donna; Kaufman, Randi; Hayden, Jennifer; Robinson, Melody] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA.
[Tai, Eric] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Williams, D (reprint author), Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD OCT
PY 2009
VL 6
IS 4
AR A139
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA V20RY
UT WOS:000208158300029
PM 19755015
ER
PT J
AU Pratt, M
Epping, JN
Dietz, WH
AF Pratt, Michael
Epping, Jacqueline N.
Dietz, William H.
TI Putting physical activity into public health: A historical perspective
from the CDC
SO PREVENTIVE MEDICINE
LA English
DT Editorial Material
DE Public health; Nutrition and obesity; Global health; Intervention
efficacy; Physical activity; Cardiovascular disease
ID ACTIVITY INTERVENTIONS
AB This commentary reviews the role that the U.S. Centers for Disease Control and Prevention (CDC) has played since 1964 in moving science, policy, and practice from exercise and fitness to physical activity and health. Published by Elsevier Inc.
C1 [Pratt, Michael; Epping, Jacqueline N.; Dietz, William H.] Ctr Dis Control & Prevent CDC, Div Nutr Phys Activ & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
RP Pratt, M (reprint author), Ctr Dis Control & Prevent CDC, Div Nutr Phys Activ & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,K-46 Atlanta, Atlanta, GA 30341 USA.
EM mpratt@cdc.gov
NR 15
TC 14
Z9 14
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
J9 PREV MED
JI Prev. Med.
PD OCT
PY 2009
VL 49
IS 4
BP 301
EP 302
DI 10.1016/j.ypmed.2009.06.011
PG 2
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 515EZ
UT WOS:000271451700010
PM 19555709
ER
PT J
AU Porter, CH
AF Porter, Charles H.
TI WYEOMYIA (HYSTATOMYIA) BALTAE, A NEW SPECIES OF SABETHINI (DIPTERA:
CULICIDAE) FROM PERU
SO PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF WASHINGTON
LA English
DT Article
DE Guzmania; mosquito; Neotropical; taxonomy
AB Wyeomyia (Hystatomyia) baltae Porter, new species is described from specimens reared from the tank bromeliad Guzmania lindenii var. concolor Rauh growing in humid premontane forest on the eastern slopes of the Peruvian Andes. The description, with relevant illustrations, is of the adult male and female, as well as the pupal and larval stages.
C1 Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA.
RP Porter, CH (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA.
EM cporter@cdc.gov
FU National Geographic Society; Departments of Cusco and Madre de Dios of
Peru [7731-04]; Naval Medical Research Center Detachment - Lima, Peru
(NMRCD Lima); Centers for Disease Control and Prevention
FX Grateful acknowledgment is given to the National Geographic Society for
support of the field studies, which were undertaken in the Departments
of Cusco and Madre de Dios of Peru (grant no. 7731-04). Recognition is
given to the Naval Medical Research Center Detachment - Lima, Peru
(NMRCD Lima), with special thanks to the Officer-in-Charge, Capt.
Gregory J. Martin, and to Lt. Jeffrey Stancil. Special thanks are also
extended to local NMRCD Lima staff, including Zoe Moran for
administrative assistance and Roberto Fernandez who participated in the
field studies and rearing of specimens. I am grateful for the very
significant contribution of Philip K. Wittman (Canopy Quest) who
participated in the field studies, recorded field data, and photographed
most of the phytotelmata sampled. Thanks are also extended to Ricardo
Fernandez (Museo de Historia Natural, Universidad Nacional Mayor de San
Marcos, Lima) for collecting and preparing herbarium specimens of many
of the phytotelm plants sampled. Jose Luis Venero Gonzales (Universidad
Nacional de San Antonio Abad) was very helpful with regard to selection
of the study area and relevant ecological data. I am grateful to Harry
E. Luther (Selby Botanical Gardens) for identification of bromeliads and
to Yasmin Rubio-Palis for loan of specimens of Wy. lopezii. Special
thanks also are given to Richard C. Wilkerson and James E. Pecor (both
Walter Reed Biosystematics Unit, Smithsonian National Museum of Natural
History) for allowing me to examine types and other relevant specimens
and for their helpful suggestions. I am grateful to Ralph E. Harbach
(The Natural History Museum, London) for a very helpful review of the
manuscript). Taina R. Litwak (Litwak Illustration Studio) prepared the
excellent illustrations. Finally, I am grateful to Robert A. Wirtz
(Centers for Disease Control and Prevention) for essential support
throughout this endeavor. The findings and conclusions in this report
are those of the author and do not necessarily represent the views of
the Centers for Disease Control and Prevention.
NR 11
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U1 0
U2 1
PU ENTOMOL SOC WASHINGTON
PI WASHINGTON
PA SMITHSONIAN INSTITUTION DEPT ENTOMOLOGY, WASHINGTON, DC 20560 USA
SN 0013-8797
J9 P ENTOMOL SOC WASH
JI Proc. Entomol. Soc. Wash.
PD OCT
PY 2009
VL 111
IS 4
BP 807
EP 825
DI 10.4289/0013-8797-111.4.807
PG 19
WC Entomology
SC Entomology
GA 515FQ
UT WOS:000271453600005
ER
PT J
AU Gillum, RF
Santibanez, S
Bennett, G
Donahue, M
AF Gillum, R. F.
Santibanez, Scott
Bennett, Glen
Donahue, Michael
TI ASSOCIATIONS OF PRAYER, MIND-BODY THERAPY, AND SMOKING CESSATION IN A
NATIONAL SURVEY
SO PSYCHOLOGICAL REPORTS
LA English
DT Article
ID CIGARETTE-SMOKING; AFRICAN-AMERICANS; INTERVENTIONS; RELAXATION;
PROGRAM; ADULTS; HEART; SOUL
AB Smoking is the leading preventable cause of death. Many people use mind-body therapies and/or prayer to assist them in smoking cessation, but more information on their effectiveness is needed. In the 2002 National Health Interview Survey, 5,864 persons aged 18 or older reported smoking in the prior 12 mo.; among these, users of any of 10 mind-body therapies or prayer were compared to nonusers to assess smoking cessation attempts and smoking cessation over a 1-yr. period. Weighted logistic regression showed that the adjusted odds of reporting quit attempts during the year prior to interview or of reporting no longer smoking at interview were significantly higher in those using prayer alone, ally mind-body therapy alone, or both, compared with those who used neither. In the Subset of 2,839 persons who reported smoking 12 mo. prior to interview and attempting to quit during the year prior to interview, the odds of reporting no longer smoking at interview were no greater for those who used prayer, any mind-body therapy, or both, than in those using neither.
C1 [Gillum, R. F.] Howard Univ, Sch Divin, Washington, DC 20017 USA.
[Gillum, R. F.] Howard Univ, Coll Med, Washington, DC 20017 USA.
[Santibanez, Scott] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Bennett, Glen] Natl Inst Hlth, Bethesda, MD 20892 USA.
[Donahue, Michael] Inst Psychol Sci, Alexandria, VA USA.
RP Gillum, RF (reprint author), Howard Univ, Sch Divin, Washington, DC 20017 USA.
EM frank.gillum@gmail.com
NR 26
TC 2
Z9 2
U1 1
U2 5
PU AMMONS SCIENTIFIC, LTD
PI MISSOULA
PA PO BOX 9229, MISSOULA, MT 59807-9229 USA
SN 0033-2941
J9 PSYCHOL REP
JI Psychol. Rep.
PD OCT
PY 2009
VL 105
IS 2
BP 593
EP 604
DI 10.2466/PR0.105.2.593-604
PG 12
WC Psychology, Multidisciplinary
SC Psychology
GA 508TM
UT WOS:000270959200029
PM 19928621
ER
PT J
AU Nakata, A
Takahashi, M
Swanson, NG
Ikeda, T
Hojou, M
AF Nakata, A.
Takahashi, M.
Swanson, N. G.
Ikeda, T.
Hojou, M.
TI Active cigarette smoking, secondhand smoke exposure at work and home,
and self-rated health
SO PUBLIC HEALTH
LA English
DT Article
DE Cigarette smoking; Secondhand smoke; Self-rated health; Worker;
Occupational health; Small and medium-size business
ID CORONARY-HEART-DISEASE; PASSIVE SMOKING; PERCEIVED HEALTH; REPORTED
HEALTH; 2ND-HAND SMOKE; SMALL-SCALE; LIFE-STYLE; HONG-KONG; FOLLOW-UP;
MORTALITY
AB Objectives: Although active smoking has been reported to be associated with poor self-rated health (SRH), its association with secondhand smoke (SHS) is not well understood.
Study design: A cross-sectional study was conducted to examine the association of active smoking and SHS exposure with SRH.
Methods: A total of 2558 workers (1899 men and 689 women), aged 16-83 (mean 45) years, in 296 small and medium-sized enterprises were surveyed by means of a self-administered questionnaire. Smoking status and exposure levels to SHS (no, occasional or regular) among lifetime non-smokers were assessed separately at work and at home. SRH was assessed with the question: How would you describe your health during the past 1-year period (very poor, poor, good, very good)? SRH was dichotomized into suboptimal (poor, very poor) and optimal (good, very good). Odds ratios (ORs) with 95% confidence intervals (CIs) for reporting suboptimal vs optimal SRH according to smoking status and smoke exposure were calculated.
Results: Current heavy smokers (20+ cigarettes/day) had a significantly increased suboptimal SRH than lifetime non-smokers after adjusting for sociodemographic, lifestyle, physical and occupational factors (OR 1.34, 95% CI 1.06-1.69). Similarly, lifetime non-smokers occasionally exposed to SHS at work alone had worse SRH than their unexposed counterparts (OR 1.50, 95% CI 1.02-2.11). In contrast, lifetime nonsmokers exposed at home alone had no significant increase in suboptimal SRH.
Conclusions: The present study indicates an increase in suboptimal SRH among current heavy smokers, and suggests that SHS exposure at work is a possible risk factor for non-smokers. Whether or not the association is causal, control of smoking at work may protect workers from developing future health conditions. Published by Elsevier Ltd on behalf of The Royal Society for Public Health.
C1 [Nakata, A.; Swanson, N. G.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA.
[Takahashi, M.] Natl Inst Occupat Safety & Hlth, Kawasaki, Kanagawa, Japan.
[Ikeda, T.] Univ Occupat & Environm Hlth, Dept Occupat & Publ Hlth, Sch Hlth Sci, Fukuoka, Japan.
[Hojou, M.] Ota Reg Occupat Hlth Ctr, Tokyo, Japan.
RP Nakata, A (reprint author), NIOSH, Ctr Dis Control & Prevent, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA.
EM cji5@cdc.gov
RI Nakata, Akinori/A-2399-2008
FU Japanese Ministry of Education, Culture, Sports, Science and Technology
[16659634]
FX The research was supported in part by the Japanese Ministry of
Education, Culture, Sports, Science and Technology (grant-in-aid for
exploratory research: 16659634).
NR 48
TC 17
Z9 19
U1 1
U2 6
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0033-3506
J9 PUBLIC HEALTH
JI Public Health
PD OCT
PY 2009
VL 123
IS 10
BP 650
EP 656
DI 10.1016/j.puhe.2009.09.006
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 533CH
UT WOS:000272799300004
PM 19875139
ER
PT J
AU Sachs, MC
Enright, PL
Stukovsky, KDH
Jiang, R
Barr, RG
AF Sachs, Michael C.
Enright, Paul L.
Stukovsky, Karen D. Hinckley
Jiang, Rui
Barr, R. Graham
CA Multi-Ethnic Study Atherosclerosis
TI Performance of Maximum Inspiratory Pressure Tests and Maximum
Inspiratory Pressure Reference Equations for 4 Race/Ethnic Groups
SO RESPIRATORY CARE
LA English
DT Article
DE diaphragm strength; respiratory muscle strength; maximum inspiratory
pressure; quality control; pulmonary function testing
ID RESPIRATORY MUSCLE STRENGTH; REFERENCE VALUES; ATHEROSCLEROSIS;
DETERMINANTS; SPIROMETRY; RISK
AB BACKGROUND: Maximum inspiratory pressure (MIP) is an important and noninvasive index of diaphragm strength and an independent predictor of all-cause mortality. The ability of adults over a wide age range and multiple race/ethnicities; to perform MIP tests has previously not been evaluated. METHODS: The Multi-Ethnic Study of Atherosclerosis recruited white, African American, Hispanic, and Chinese American participants, ages 45-84 years, and free of clinical cardiovascular disease in 6 United States cities. MIP was measured using standard techniques among 3,849 Multi-Ethnic Study of Atherosclerosis participants. The MIP quality goal was 5 maneuvers, with the 2 largest values matching within 10 cm H(2)O. Correlates of MIP quality and values were assessed in logistic and linear regression models. RESULTS: The 3,849 participants with MIP measures were 51% female, 35% white, 26% African American, 23% Hispanic, and 16% Chinese American. Mean +/- SD MIP was 73 +/- 26 cm H(2)O for women and 97 +/- 29 cm H(2)O for men. The quality goal was achieved by 83% of the cohort and was associated with female sex, older age, race/ethnicity, study site, low ratio of forced expiratory volume in the first second to forced vital capacity (FEV(1)/FVC), and wheeze with dyspnea. The multivariate correlates of MIP were male sex, younger age, higher body mass index, shorter height, higher FVC, higher systolic blood pressure (in women) and health status (in men). There were no clinically important race/ethnic differences in MIP values. CONCLUSIONS: Race-specific reference equations for MIP are unnecessary in the United States. More than 80% of adults can be successfully coached for 5 maneuvers, with repeatability within 10 cm H(2)O.
C1 [Jiang, Rui; Barr, R. Graham] Columbia Univ, Med Ctr, Dept Med, Coll Phys & Surg, New York, NY 10032 USA.
[Sachs, Michael C.; Stukovsky, Karen D. Hinckley] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
[Enright, Paul L.] Univ Arizona, Coll Med, Resp Sci Ctr, Tucson, AZ 85724 USA.
[Enright, Paul L.] NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Barr, RG (reprint author), Columbia Univ, Med Ctr, Dept Med, Coll Phys & Surg, 630 W 168th St,PH 9 E,Room 105, New York, NY 10032 USA.
EM rgb9@columbia.edu
FU NHLBI NIH HHS [N01-HC-95159, R01 HL077612, N01 HC095159, N01-HC-95165,
R01 HL075476, N01HC95159, N01HC95169, N01-HC95169, R01-HL077612, N01
HC095169, N01HC95165]
NR 19
TC 18
Z9 19
U1 0
U2 1
PU DAEDALUS ENTERPRISES INC
PI IRVING
PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA
SN 0020-1324
J9 RESP CARE
JI Respir. Care
PD OCT
PY 2009
VL 54
IS 10
BP 1321
EP 1328
PG 8
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA 509WZ
UT WOS:000271051300006
PM 19796411
ER
PT J
AU Wassell, JT
AF Wassell, James T.
TI Workplace violence intervention effectiveness: A systematic literature
review
SO SAFETY SCIENCE
LA English
DT Article
DE Workplace; Violence; Assault; Homicide; Occupational
ID WORK-RELATED ASSAULT; RISK-FACTORS; PREVENTION STRATEGIES;
ENVIRONMENTAL-DESIGN; MINNESOTA NURSES; CRIME-PREVENTION; ROBBERY RISK;
PROGRAM; MANAGEMENT; AGGRESSION
AB This is a systematic review of literature published since 1992, to determine the effectiveness of interventions in preventing workplace violence and to suggest interventions that need further evaluation research. The health care industry is the topic of 54% of the papers, the retail industry is the topic of 11% of the papers, and the remaining papers address the workplace in general or other situations. This finding drives the organization of this review: the first group of papers discussed in this review evaluates interventions to prevent workplace violence in the retail industry - mostly to prevent robbery and violence to retail workers. Singly or in combination, environmental designs in the retail industry, such as increased lighting to improve visibility and a limited cash-handling policy, can make workers safer, but more research is needed to overcome the barriers to implementation of environmental designs, especially in small businesses. The second group of papers in this review is about interventions to prevent violence to health care workers - mostly training and techniques of dealing with combative patients, Training health care workers to better cope with violent patients and to avoid injury is becoming standard practice, but research is needed to identify specific aspects of training and patient management programs that are most effective. Published by Elsevier Ltd.
C1 Ctr Dis Control & Prevent, NIOSH, Div Safety Res, Anal & Field Evaluat Branch, Morgantown, WV 26505 USA.
RP Wassell, JT (reprint author), Ctr Dis Control & Prevent, NIOSH, Div Safety Res, Anal & Field Evaluat Branch, 1095 Willowdale Rd,M-S 1811, Morgantown, WV 26505 USA.
EM JWassell@cdc.gov
NR 57
TC 28
Z9 28
U1 5
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-7535
J9 SAFETY SCI
JI Saf. Sci.
PD OCT
PY 2009
VL 47
IS 8
BP 1049
EP 1055
DI 10.1016/j.ssci.2008.12.001
PG 7
WC Engineering, Industrial; Operations Research & Management Science
SC Engineering; Operations Research & Management Science
GA 466AF
UT WOS:000267631800001
ER
PT J
AU Shrestha, RK
Begley, EB
Hutchinson, AB
Sansom, SL
Song, BW
Voorhees, K
Busby, A
Carrel, J
Burgess, S
AF Shrestha, Ram K.
Begley, Elin B.
Hutchinson, Angela B.
Sansom, Stephanie L.
Song, Binwei
Voorhees, Kelly
Busby, Amy
Carrel, Jack
Burgess, Samuel
TI Costs and Effectiveness of Partner Counseling and Referral Services With
Rapid Testing for HIV in Colorado and Louisiana, United States
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
ID RANDOMIZED-TRIAL; NOTIFICATION; INFECTION; VIRUS; PREVENTION;
STRATEGIES; SETTINGS
AB Objective: Health departments offer partner counseling and referral services (PCRS) to HIV-infected index patients and their partners. Point-of-care rapid HIV testing makes it possible for partners of index patients to learn their HIV serostatus in nonclinical settings.
Study Design: We assessed costs and effectiveness of PCRS with rapid HIV testing in Colorado and Louisiana (April 2004-January 2006). Colorado provided PCRS to the index patients and partners statewide; Louisiana provided PCRS to those in Baton Rouge and New Orleans. The key effectiveness measures were number of partners tested and number of partners informed of a new HIV diagnosis after rapid testing. We obtained program costs for personnel, travel, utilities, supplies, equipment, and facility space.
Results: Colorado identified a yearly average of 328 index patients and 253 partners and tested 43 partners. Louisiana identified a yearly average of 81 index patients and 138 partners and tested 83 partners. The rates of previously undiagnosed HIV infection among partners tested were 6.6% in Colorado and 9.9% in Louisiana. The average costs per partner tested and per partner informed of a new HIV diagnosis were $1459 and $22,243 in Colorado and $714 and $7231 in Louisiana.
Conclusions: Program cost,; varied substantially by location. Our analysis helps program managers and health care providers to understand the resources needed for implementing the PCRS in diverse settings.
C1 [Shrestha, Ram K.; Begley, Elin B.; Hutchinson, Angela B.; Sansom, Stephanie L.; Song, Binwei] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
[Voorhees, Kelly] Colorado Dept Publ Hlth & Environm, Denver, CO USA.
[Busby, Amy; Carrel, Jack; Burgess, Samuel] Louisiana Off Publ Hlth, New Orleans, LA USA.
RP Shrestha, RK (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Mail Stop E48,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM biu0@cdc.gov
NR 29
TC 10
Z9 10
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-5717
EI 1537-4521
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD OCT
PY 2009
VL 36
IS 10
BP 637
EP 641
DI 10.1097/OLQ.0b013e3181a96d3d
PG 5
WC Infectious Diseases
SC Infectious Diseases
GA 500GN
UT WOS:000270286900007
PM 19955875
ER
PT J
AU Christiansen-Lindquist, L
Tao, GY
Hoover, K
Frank, R
Kent, C
AF Christiansen-Lindquist, Lauren
Tao, Guoyu
Hoover, Karen
Frank, Robbie
Kent, Charlotte
TI Chlamydia Screening of Young Sexually Active, Medicaid-Insured Women by
Race and Ethnicity, 2002-2005
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
ID UNITED-STATES; ADULTS; RATES
AB Objective: To estimate chlamydia screening rates of young sexually active Medicaid-insured women by race and ethnicity and age from 2002 to 2005.
Methods: Using Medicaid child claims data from the MarketScan database, we estimated the proportion of sexually active women aged 15 to 21 years screened for chlamydia by race and ethnicity and by age group (15-16, 17-18, and 19-21 years) using codes for medical diagnostic and procedural claims.
Results: Overall, chlamydia screening increased from 34% in 2002 to 44% in 2005. In all years, black women had significantly higher screening rates compared with white women (e.g., 51% vs. 39% in 2005). When stratified by age. black women were still significantly more likely to be screened for chlamydia than white women.
Conclusions: Although it is encouraging that screening has increased over time and that black women were more likely to be screened than white women, rates remain suboptimal for all women. Effective and targeted interventions are needed to improve chlamydia screening of young women. As interventions to increase screening are developed and implemented, the estimation method described in this article can be used to track chlamydia screening trends in racial and ethnic populations over time.
C1 [Christiansen-Lindquist, Lauren; Tao, Guoyu; Hoover, Karen; Frank, Robbie; Kent, Charlotte] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
[Christiansen-Lindquist, Lauren] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
RP Tao, GY (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE MS E-80, Atlanta, GA 30333 USA.
EM gat3@cdc.gov
NR 19
TC 6
Z9 6
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-5717
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD OCT
PY 2009
VL 36
IS 10
BP 642
EP 646
DI 10.1097/OLQ.0b013e3181ab481b
PG 5
WC Infectious Diseases
SC Infectious Diseases
GA 500GN
UT WOS:000270286900008
PM 19652631
ER
PT J
AU Owusu-Edusei, K
Chesson, HW
AF Owusu-Edusei, Kwame, Jr.
Chesson, Harrell W.
TI Using Spatial Regression Methods to Examine the Association Between
County-Level Racial/Ethnic Composition and Reported Cases of Chlamydia
and Gonorrhea: An Illustration With Data From the State of Texas
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
ID PELVIC-INFLAMMATORY-DISEASE; SEXUALLY-TRANSMITTED INFECTIONS; GEOGRAPHIC
INFORMATION-SYSTEM; UNITED-STATES; SOCIAL-CONTEXT; CORE; TRANSMISSION;
PREVENTION; BALTIMORE; NETWORKS
AB Background: Several studies have reported racial/ethnic disparities in the incidence of sexually transmitted diseases. However, very few studies have accounted for potential spatial dependence. Additionally, little is known about the relative magnitudes of the associations between county-level racial/ethnic composition and the 2 most commonly reported sexually transmitted diseases.
Methods: We used county-level data from the National Electronic Telecommunications System for Surveillance and the 2000 Census data to investigate the association between county-level racial/ethnic composition and reported cases of the 2 most commonly reported sexually transmitted diseases (chlamydia and gonorrhea) in Texas. We also estimated ordinary least square (OLS) models for comparison.
Results: Preliminary results from the spatial regression models indicated that the choice of spatial relationships criteria was important for model specification. The spatial error model (SEM) was superior to the spatial autoregressive model, spatial Durbin model, and OLS. The SEM for the 2 disease equations were further analyzed using a seemingly unrelated regression estimation (SURE) procedure. Although the SEM was superior to all models (using standard criteria), the coefficients were fairly stable across models. Our results showed that a unit change in percent black was associated with 1.6 (1.1 for Hispanic) and 3.3 (0.5 for Hispanic) percent change in chlamydia and gonorrhea rates (on average), respectively, compared with percent white.
Conclusion: Although there were no substantial differences in the magnitude of the estimated parameters, spatial regression models are potentially superior to OLS models and should be explored in future sexually transmitted disease studies.
C1 [Owusu-Edusei, Kwame, Jr.; Chesson, Harrell W.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA.
RP Owusu-Edusei, K (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd MS E-80, Atlanta, GA 30333 USA.
EM kowusuedusei@cdc.gov
NR 58
TC 10
Z9 11
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-5717
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD OCT
PY 2009
VL 36
IS 10
BP 657
EP 664
DI 10.1097/OLQ.0b013e3181b6ac93
PG 8
WC Infectious Diseases
SC Infectious Diseases
GA 500GN
UT WOS:000270286900010
PM 19734821
ER
PT J
AU Liao, YL
Greenlund, KJ
Croft, JB
Keenan, NL
Giles, WH
AF Liao, Youlian
Greenlund, Kurt J.
Croft, Janet B.
Keenan, Nora L.
Giles, Wayne H.
TI Factors Explaining Excess Stroke Prevalence in the US Stroke Belt
SO STROKE
LA English
DT Article
DE epidemiology; public policy; risk factors
ID SOUTHEASTERN UNITED-STATES; MORTALITY; HYPERTENSION; REGION; VALIDITY;
BLACKS; WHITES; HEALTH; RISK
AB Background and Purpose-Higher risk and burden of stroke have been observed within the southeastern states (the Stroke Belt) compared with elsewhere in the United States. We examined reasons for these disparities using a large data set from a nationwide cross-sectional study.
Methods-Self-reported data from the 2005 and 2007 Behavioral Risk Factor Surveillance System were used (n = 765 368). The potential contributors for self-reported stroke prevalence (n = 27 962) were demographics (age, sex, geography, and race/ethnicity), socioeconomic status (education and income), common risk factors (smoking and obesity), and chronic diseases (hypertension, diabetes, and coronary heart disease). Multivariate logistic regression was used in the analysis.
Results-The age-and sex-adjusted OR comparing self-reported stroke prevalence in the 11-state Stroke Belt versus non-Stroke Belt region was 1.25 (95% CI, 1.19 to 1.31). Unequal black/white distribution by region accounted for 20% of the excess prevalence in the Stroke Belt (OR reduced to 1.20; 1.15 to 1.26). Approximately one third (32%) of the excess prevalence was accounted either by socioeconomic status alone or by risk factors and chronic disease alone (OR, 1.12). The OR was further reduced to 1.07 (1.02 to 1.13) in the fully adjusted logistic model, a 72% reduction.
Conclusions-Differences in socioeconomic status, risk factors, and prevalence of common chronic diseases account for most of the regional differences in stroke prevalence. (Stroke. 2009;40:3336-3341.)
C1 [Liao, Youlian; Greenlund, Kurt J.; Croft, Janet B.; Giles, Wayne H.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Keenan, Nora L.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
RP Liao, YL (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop K-30, Atlanta, GA 30341 USA.
EM ycl1@cdc.gov
NR 21
TC 55
Z9 57
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0039-2499
J9 STROKE
JI Stroke
PD OCT
PY 2009
VL 40
IS 10
BP 3336
EP 3341
DI 10.1161/STROKEAHA.109.561688
PG 6
WC Clinical Neurology; Peripheral Vascular Disease
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA 499NV
UT WOS:000270229800030
PM 19679841
ER
PT J
AU MacClellan, LR
Howard, TD
Cole, JW
Stine, OC
Giles, WH
O'Connell, JR
Wozniak, MA
Stern, BJ
Mitchell, BD
Kittner, SJ
AF MacClellan, Leah R.
Howard, Timothy D.
Cole, John W.
Stine, O. Colin
Giles, Wayne H.
O'Connell, Jeffery R.
Wozniak, Marcella A.
Stern, Barney J.
Mitchell, Braxton D.
Kittner, Steven J.
TI Relation of Candidate Genes that Encode for Endothelial Function to
Migraine and Stroke The Stroke Prevention in Young Women Study
SO STROKE
LA English
DT Article
DE endothelium; ischemia; migraine; stroke in young adults
ID SMALL-VESSEL DISEASE; OXIDE SYNTHASE GENE; NITRIC-OXIDE;
ISCHEMIC-STROKE; BLOOD-PRESSURE; RISK-FACTOR; NITRIC-OXIDE-SYNTHASE-3
GENE; PROMOTER POLYMORPHISMS; GLU298ASP POLYMORPHISM;
MYOCARDIAL-INFARCTION
AB Background and Purpose-Migraine with aura is a risk factor for ischemic stroke, but the mechanism by which these disorders are associated remains unclear. Both disorders exhibit familial clustering, which may imply a genetic influence on migraine and stroke risk. Genes encoding for endothelial function are promising candidate genes for migraine and stroke susceptibility because of the importance of endothelial function in regulating vascular tone and cerebral blood flow.
Methods-Using data from the Stroke Prevention in Young Women study, a population-based case-control study including 297 women aged 15 to 49 years with ischemic stroke and 422 women without stroke, we evaluated whether polymorphisms in genes regulating endothelial function, including endothelin-1 (EDN), endothelin receptor type B (EDNRB), and nitric oxide synthase-3 (NOS3), confer susceptibility to migraine and stroke.
Results-EDN SNP rs1800542 and rs10478723 were associated with increased stroke susceptibility in whites (OR, 2.1; 95% CI, 1.1-4.2 and OR, 2.2; 95% CI, 1.1-4.4; P = 0.02 and 0.02, respectively), as were EDNRB SNP rs4885493 and rs10507875, (OR, 1.7; 95% CI, 1.1-2.7 and OR, 2.4; 95% CI, 1.4-4.3; P = 0.01 and 0.002, respectively). Only 1 of the tested SNP (NOS3 rs3918166) was associated with both migraine and stroke.
Conclusions-In our study population, variants in EDN and EDNRB were associated with stroke susceptibility in white but not in black women. We found no evidence that these genes mediate the association between migraine and stroke. (Stroke. 2009;40:e550-e557.)
C1 [Cole, John W.] Univ Maryland, Sch Med, Dept Neurol, Maryland Stroke Ctr, Baltimore, MD 21201 USA.
[MacClellan, Leah R.; Stine, O. Colin; Mitchell, Braxton D.] Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA.
[O'Connell, Jeffery R.; Mitchell, Braxton D.] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA.
[Howard, Timothy D.] Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA.
[Cole, John W.; Wozniak, Marcella A.; Stern, Barney J.; Kittner, Steven J.] VA Maryland Hlth Care Syst, Baltimore, MD USA.
[Giles, Wayne H.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Cole, JW (reprint author), Univ Maryland, Sch Med, Dept Neurol, Maryland Stroke Ctr, 12th Floor,Bressler Bldg,Room 12-006,655 W Baltim, Baltimore, MD 21201 USA.
EM jcole@som.umaryland.edu
OI Mitchell, Braxton/0000-0003-4920-4744
FU Office of Research and Development, Medical Research Service; Research
Enhancement Award Program in Stroke, the Geriatrics Research, Education,
and Clinical Center, Department of Veterans Affairs; Cooperative
Agreement with the Cardiovascular Health Branch, Division of Adult and
Community Health, Centers for Disease Control; National Institute of
Neurological Disorders and Stroke (NINDS); NIH Office of Research on
Women's Health (ORWH) [R01 NS45012]; National Institute on Aging (NIA)
Pepper Center [P60 12583]; University of Maryland General Clinical
Research Center [M01 RR 165001]; National Center for Research Resources
(NCRR), NIH
FX This material is based on work supported in part by the Office of
Research and Development, Medical Research Service, and the Research
Enhancement Award Program in Stroke, the Geriatrics Research, Education,
and Clinical Center, Department of Veterans Affairs; a Cooperative
Agreement with the Cardiovascular Health Branch, Division of Adult and
Community Health, Centers for Disease Control; the National Institute of
Neurological Disorders and Stroke (NINDS) and the NIH Office of Research
on Women's Health (ORWH) R01 NS45012; the National Institute on Aging
(NIA) Pepper Center Grant P60 12583; and the University of Maryland
General Clinical Research Center Grant M01 RR 165001, General Clinical
Research Centers Program, National Center for Research Resources (NCRR),
NIH.
NR 52
TC 20
Z9 22
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0039-2499
J9 STROKE
JI Stroke
PD OCT
PY 2009
VL 40
IS 10
BP E550
EP E557
DI 10.1161/STROKEAHA.109.557462
PG 8
WC Clinical Neurology; Peripheral Vascular Disease
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA 499NV
UT WOS:000270229800044
PM 19661472
ER
PT J
AU Fowlkes, AL
Brown, C
Amin, MM
Roback, JD
Downing, R
Nzaro, E
Mermin, J
Hladik, W
Dollard, SC
AF Fowlkes, Ashley L.
Brown, Cedric
Amin, Minal M.
Roback, John D.
Downing, Robert
Nzaro, Esau
Mermin, Jonathan
Hladik, Wolfgang
Dollard, Sheila C.
TI Quantitation of human herpesvirus 8 (HHV-8) antibody in patients
transfused with HHV-8-seropositive blood
SO TRANSFUSION
LA English
DT Article
ID KAPOSIS-SARCOMA; INTRAVENOUS IMMUNOGLOBULIN; SEROLOGIC ASSAYS;
TRANSMISSION; INFECTION; DONORS; CMV; VIRUS; CYTOMEGALOVIRUS; RECIPIENTS
AB BACKGROUND:
Human herpesvirus 8 (HHV-8) is endemic in Uganda where seroprevalence is approximately 40%. In a previous study, Ugandan patients receiving blood transfusions had multiple serum specimens collected for 6 months after transfusion to monitor for HHV-8 infection. It was observed that several HHV-8-seronegative patients were unexpectedly HHV-8 seropositive after blood transfusion.
STUDY DESIGN AND METHODS:
This study measured HHV-8 antibody in serially collected serum specimens from 542 patients who received transfusions and evaluated the risk of HHV-8 infection as a function of HHV-8 antibody levels in the donors.
RESULTS:
HHV-8 antibody was observed in 52% of patients transfused with HHV-8-seropositive blood in amounts that corresponded with their donor's antibody titer and waned within 40 days. Higher levels of passive HHV-8 antibody in patients who received transfusions appeared to be associated with a lower risk of HHV-8 infection.
CONCLUSION:
The source of transient antibody in patients who received transfusions was determined to be the transfused blood. Donors with higher HHV-8 antibody titers may have been less likely to have infectious virus in the blood.
C1 [Dollard, Sheila C.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
Emory Univ, Ctr Transfus & Cellular Therapies, Dept Pathol & Lab Med, Sch Med, Atlanta, GA USA.
Mulago Hosp, Kampala, Uganda.
CDC, Global AIDS Program, Entebbe, Uganda.
CDC Kenya, Coordinating Off Global Hlth, Nairobi, Kenya.
RP Dollard, SC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Mailstop G-18,1600 Clifton Rd NE, Atlanta, GA 30333 USA.
EM sgd5@cdc.gov
RI Mermin, Jonathan/J-9847-2012
NR 21
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U1 0
U2 1
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD OCT
PY 2009
VL 49
IS 10
BP 2208
EP 2213
DI 10.1111/j.1537-2995.2009.02269.x
PG 6
WC Hematology
SC Hematology
GA 502BW
UT WOS:000270430100030
PM 19555417
ER
PT J
AU Beltrao, HDM
Cerroni, MD
de Freitas, DRC
Pinto, AYD
Valente, VD
Valente, SA
Costa, ED
Sobel, J
AF Moreira Beltrao, Henrique de Barros
Cerroni, Matheus de Paula
Coradi de Freitas, Daniel Roberto
das Neves Pinto, Ana Yece
Valente, Vera da Costa
Valente, Sebastiao Aldo
Costa, Elenild de Goes
Sobel, Jeremy
TI Investigation of two outbreaks of suspected oral transmission of acute
Chagas disease in the Amazon region, Para State, Brazil, in 2007
SO TROPICAL DOCTOR
LA English
DT Article
AB Acute Chagas disease (ACD) is caused by Trypanosoma cruzi. ACD outbreaks due to probable oral transmission occur regularly in small family gatherings that are exposed to contaminated foods. We studied two cohorts of residents on islands in the Breves and Bagre municipalities, in July and August 2007, to identify risk factors of transmission and to recommend preventative measures. Of the 25 cases identified in both cohorts, 13 (52%) were men, and the most frequent symptoms were fever (96%), asthenia (80%), myalgia (76%), abdominal pain (64%), retro-orbital pain, headaches and asthma (52%). We recommend detailed investigation of future outbreaks and other studies to better understand and control oral transmission of T. cruzi.
C1 [Moreira Beltrao, Henrique de Barros; Cerroni, Matheus de Paula; Coradi de Freitas, Daniel Roberto; Sobel, Jeremy] Minist Hlth, Secretariat Hlth Surveillance, Field Epidemiol, Training Program, Brasilia, DF, Brazil.
[Coradi de Freitas, Daniel Roberto] Minist Hlth, Natl Agcy Sanit Surveillance, Brasilia, DF, Brazil.
[das Neves Pinto, Ana Yece; Valente, Vera da Costa; Valente, Sebastiao Aldo] Minist Hlth, Secretariat Hlth Surveillance, Evandro Chagas Inst, Belem, Para, Brazil.
[Costa, Elenild de Goes] Secretariat Publ Hlth, Belem, Para, Brazil.
[Sobel, Jeremy] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Beltrao, HDM (reprint author), Minist Hlth, Secretariat Hlth Surveillance, Field Epidemiol, Training Program, Brasilia, DF, Brazil.
EM henrique.beltrao@saude.gov.br
FU State Secretariat of Health Surveillance of the Ministry of Health
FX We thank the State Secretariat of Health Surveillance of the Ministry of
Health and its network of collaborators for supporting this work.
NR 10
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U1 0
U2 1
PU ROYAL SOC MEDICINE PRESS LTD
PI LONDON
PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND
SN 0049-4755
J9 TROP DOCT
JI Trop. Dr.
PD OCT
PY 2009
VL 39
IS 4
BP 231
EP 232
DI 10.1258/td.2009.090035
PG 2
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 519OR
UT WOS:000271777000015
ER
PT J
AU Anand, A
Shiraishi, RW
Sheikh, AA
Marum, LH
Bolu, O
Mutsotso, W
Sabin, K
Ayisi, R
Diaz, T
AF Anand, Abhijeet
Shiraishi, Ray W.
Sheikh, Abdullahi Ahmed
Marum, Lawrence H.
Bolu, Omotayo
Mutsotso, Winfred
Sabin, Keith
Ayisi, Robert
Diaz, Theresa
TI Site factors may be more important than participant factors in
explaining HIV test acceptance in the prevention of mother-to-child HIV
transmission programme in Kenya, 2005
SO TROPICAL MEDICINE & INTERNATIONAL HEALTH
LA English
DT Article
DE HIV/AIDS; PMTCT testing; Kenya; ANC surveillance; opt-out HIV testing
ID OPT-OUT; ROUTINE; ACCEPTABILITY; WOMEN
AB OBJECTIVE To determine the role of participant factors on the acceptance of a Prevention-of-Mother-to-Child (PMTCT) HIV test programme in a situation with an opt-out testing strategy.
METHODS We analysed antenatal clinic (ANC) HIV sentinel surveillance data. All 43 sites in the 2005 round of Kenya's ANC surveillance offered opt-out PMTCT services and recorded if women were offered PMTCT HIV testing and whether they accepted or refused. Logistic regression was used to determine the role of participant-level factors on PMTCT acceptance.
RESULTS During the period of sentinel surveillance, 13 026 women attended ANC and testing was offered to 12 030 women. Of those offered testing, 9690 (80.5%) accepted, with a large variation in the percent of acceptors by site. Age, residence and educational status were significant determinants of PMTCT acceptance. However, after adjusting for site none of the participant-level factors were significant determinants of PMTCT acceptance.
CONCLUSIONS Participant level factors were not significant determinants of PMTCT HIV test acceptance after adjusting for sites. PMTCT programmes should collect and evaluate the role of site-level (provider and testing service) factors on PMTCT acceptance. Improvement of site-level factors could improve PMTCT uptake.
C1 [Anand, Abhijeet] Ctr Dis Control & Prevent, Global Immunizat Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Anand, Abhijeet] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA.
[Shiraishi, Ray W.; Marum, Lawrence H.; Bolu, Omotayo; Diaz, Theresa] Ctr Dis Control & Prevent, Global AIDS Program, NCHHSTP, Atlanta, GA 30333 USA.
[Sheikh, Abdullahi Ahmed; Ayisi, Robert] NASCOP, Minist Hlth, Nairobi, Kenya.
[Sabin, Keith] WHO, HIV Dept, CH-1211 Geneva, Switzerland.
RP Anand, A (reprint author), Ctr Dis Control & Prevent, Global Immunizat Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,MS E05, Atlanta, GA 30333 USA.
EM aanand@cdc.gov
OI Sabin, Keith/0000-0002-2290-8621
FU Epidemic Intelligence Service Programme in Atlanta, USA; President's
Emergency Plan for AIDS Relief in Atlanta, USA; Nairobi, Kenya
FX We thank all participants of ANC surveillance in Kenya. We are grateful
to the Ministry of Health of Kenya and to staff who conducted data
collection, laboratory testing and data management. Support for this
analysis was provided by the Epidemic Intelligence Service Programme in
Atlanta, USA and the President's Emergency Plan for AIDS Relief in
Atlanta, USA and Nairobi, Kenya. The findings and conclusions in this
paper are those of the authors and do not necessarily represent the
views of the Centers for Disease Control and Prevention.
NR 17
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U1 0
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PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1360-2276
J9 TROP MED INT HEALTH
JI Trop. Med. Int. Health
PD OCT
PY 2009
VL 14
IS 10
BP 1215
EP 1219
DI 10.1111/j.1365-3156.2009.02367.x
PG 5
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 494KE
UT WOS:000269810800007
PM 19708898
ER
PT J
AU Ernst, KC
Lindblade, KA
Koech, D
Sumba, PO
Kuwuor, DO
John, CC
Wilson, ML
AF Ernst, Kacey C.
Lindblade, Kim A.
Koech, David
Sumba, Peter O.
Kuwuor, Dickens O.
John, Chandy C.
Wilson, Mark L.
TI Environmental, socio-demographic and behavioural determinants of malaria
risk in the western Kenyan highlands: a case-control study
SO TROPICAL MEDICINE & INTERNATIONAL HEALTH
LA English
DT Article
DE highland malaria; Plasmodium falciparum; case-control; risk factors;
environmental; household-level
ID AREA; TRANSMISSION; TEMPERATURE; PROXIMITY; EPIDEMIC; CHILDREN; WEALTH
AB OBJECTIVE To identify risk factors for uncomplicated malaria in highland areas of East Africa at higher risk of malaria epidemics, in order to design appropriate interventions.
METHODS Prospective, population-based, case-control study in the Nandi Hills, a highland area of western Kenya, to identify environmental, sociodemographic and behavioural factors associated with clinical malaria. Data were collected using field observation, a structured questionnaire, and a global positioning system device.
RESULTS We interviewed 488 cases of slide-confirmed malaria and 980 age-matched controls. Multivariate analyses associated higher malaria risk with living < 250 m of a forest [OR = 3.3 (95% CI 1.5, 7.1)], < 250 m of a swamp [2.8 (1.3, 5.9)], < 200 m of maize fields [2.0 (1.2, 3.4)], in the absence of trees < 200 m [1.6 (1.2, 2.2)], on flat land [1.6 (1.2, 2.2)], in houses without ceilings [1.5 (1.1, 2.2)], in houses with a separate kitchen building [1.8 (1.4, 2.3)] and in households where the female household head had no education [1.9 (1.1, 3.1)]. Travelling out of the study site [2.2 (1.2, 4.1)] was also associated with increased risk.
CONCLUSIONS In this East African highland area, risk of developing uncomplicated malaria was multifactorial with a risk factor profile similar to that in endemic regions. Households within close proximity to forest and swamp borders are at higher risk of malaria and should be included in indoor residual spraying campaigns.
C1 [Ernst, Kacey C.; Wilson, Mark L.] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
[Lindblade, Kim A.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA.
[Koech, David] Kenya Div Vector Borne Dis, Kapsabet, Kenya.
[Sumba, Peter O.; Kuwuor, Dickens O.] Kenya Govt Med Res Ctr, Ctr Vector Biol & Control Res, Kisumu, Kenya.
[John, Chandy C.] Univ Minnesota, Sch Med, Div Pediat Infect Dis, Minneapolis, MN 55455 USA.
RP Ernst, KC (reprint author), Univ Arizona, Div Epidemiol & Biostat, 1295 N Martin Ave, Tucson, AZ 85724 USA.
EM kernst@email.arizona.edu
RI Ernst, Kacey/M-5943-2013
FU communities of Kipsamoite and Kapsisiywa; USPHS [AI-056184, AI-01572];
Global Health Program at the University of Michigan
FX We thank the communities of Kipsamoite and Kapsisiywa for their
incredible support of this research. The work would not have been
possible without the contribution of the field assistants (Rosebella
Chepchumba, Paul Lelei, Peter Cheboiywo, Usillah Biwott, Haron Rugut,
Moses Sawe, Gideon Kurgat, Josphat Koech, Raymond Bungei, Steven Koros,
Japheth Koech, Jeruto Ogla, Jepn'getich Melly, Celestine Rotich, Japhet
Kipleting, Simeon Kipleting, Dorothy Kirwa), the microscopists (John
Oluoch, Joseph Otieno), the study coordinators (Lillian Kipkagat, Peter
Siwat), and the clinical officer (Willy Rotich). Financial support was
provided by USPHS grants (AI-056184 and AI-01572) and the Global Health
Program at the University of Michigan. The findings and conclusions in
this [presentation / report] are those of the author(s) and do not
necessarily represent the views of the Centers for Disease Control and
Prevention.
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U1 0
U2 7
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1360-2276
J9 TROP MED INT HEALTH
JI Trop. Med. Int. Health
PD OCT
PY 2009
VL 14
IS 10
BP 1258
EP 1265
DI 10.1111/j.1365-3156.2009.02370.x
PG 8
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 494KE
UT WOS:000269810800013
PM 19772547
ER
PT J
AU Brinkerhoff, RJ
Collinge, SK
Bai, Y
Ray, C
AF Brinkerhoff, R. Jory
Collinge, Sharon K.
Bai, Ying
Ray, Chris
TI Are Carnivores Universally Good Sentinels of Plague?
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Boulder County; Colorado; Cynomys ludovicianus; disease ecology;
pathogen dispersal; Yersinia pestis
ID TAILED PRAIRIE DOGS; COYOTES CANIS-LATRANS; YERSINIA-PESTIS; DOMESTIC
ANIMALS; STRIPED SKUNKS; TRANSMISSION; OUTBREAKS; CERATOPHYLLIDAE;
EPIDEMIOLOGY; SURVEILLANCE
AB Sylvatic plague, caused by the bacterium Yersinia pestis, is a flea-borne disease that primarily affects rodents but has been detected in over 200 mammal species worldwide. Mammalian carnivores are routinely surveyed as sentinels of local plague activity, since they can present antibodies to Y. pestis infection but show few clinical signs. In Boulder County, Colorado, USA, plague epizootic events are episodic and occur in black-tailed prairie dogs. Enzootic hosts are unidentified as are plague foci. For three years, we systematically sampled carnivores in two distinct habitat types to determine whether carnivores may play a role in maintenance or transmission of Y. pestis and to identify habitats associated with increased plague prevalence. We sampled 83 individuals representing six carnivore species and found only two that had been exposed to Y. pestis. The low overall rate of plague exposure in carnivores suggests that plague may be ephemeral in this study system, and thus we cannot draw any conclusions regarding habitat-associated plague foci or temporal changes in plague activity. Plague epizootics involving prairie dogs were confirmed in this study system during two of the three years of this study, and we therefore suggest that the targeting carnivores to survey for plague may not be appropriate in all ecological systems.
C1 [Brinkerhoff, R. Jory; Collinge, Sharon K.; Bai, Ying; Ray, Chris] Univ Colorado, Dept Ecol & Evolutionary Biol, Boulder, CO 80309 USA.
[Collinge, Sharon K.] Univ Colorado, Environm Studies Program, Boulder, CO 80309 USA.
[Bai, Ying] Ctr Dis Control & Prevent, Bacterial Zoonoses Branch, Div Vector Borne Infect Dis, Ft Collins, CO USA.
RP Brinkerhoff, RJ (reprint author), Univ Colorado, Dept Ecol & Evolutionary Biol, Box 334, Boulder, CO 80309 USA.
EM robert.brinkerhoff@colorado.edu
RI Brinkerhoff, Jory/I-9364-2012;
OI RAY, CHRIS/0000-0002-7963-9637
FU Boulder County Parks and Open Space Department; Boulder County Nature
Association; Museum of Natural History at the University of Colorado;
Colorado Chapter of the Wildlife Society; Beverly Sears Fund; Department
of Ecology and Evolutionary Biology at the University of Colorado;
US-EPA [R-82909101-0]; NSF/NIH joint program in Ecology of Infectious
Diseases [DEB-0224328]
FX This research was funded by grants to RJB from the Boulder County Parks
and Open Space Department, the Boulder County Nature Association, the
Museum of Natural History at the University of Colorado, the Colorado
Chapter of the Wildlife Society, the Beverly Sears Fund, and the
Department of Ecology and Evolutionary Biology at the University of
Colorado. Additional support was provided though an Edna Bailey Sussman
internship grant to RJB and research grants from the National Center for
Environmental Research (NCER) STAR program of the US-EPA (R-82909101-0)
and the NSF/NIH joint program in Ecology of Infectious Diseases
(DEB-0224328) to SKC et al. Logistical support was provided by Mark
Brennan, Sheldon Frost, Kevin Grady, Rob Alexander, Al Petkus, and
Silvia Iorio. We would also like to thank Dave Armstrong, Jason Knouft,
Andy Martin, Michelle Sauther, and two anonymous reviewers who provided
comments on an earlier version of this manuscript.
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U2 12
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD OCT
PY 2009
VL 9
IS 5
BP 491
EP 497
DI 10.1089/vbz.2008.0075
PG 7
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 507OO
UT WOS:000270864200007
PM 18973449
ER
PT J
AU Vilcins, IME
Kosoy, M
Old, JM
Deane, EM
AF Vilcins, Inger-Marie E.
Kosoy, Michael
Old, Julie M.
Deane, Elizabeth M.
TI Bartonella-Like DNA Detected in Ixodes tasmani Ticks (Acari: Ixodida)
Infesting Koalas (Phascolarctos cinereus) in Victoria, Australia
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Bartonella; Ectoparasites; Ixodes tasmani; Koalas; gltA; Australia
ID CAT-SCRATCH DISEASE; BURGDORFERI SENSU-LATO; RICINUS TICKS;
BORRELIA-BURGDORFERI; PHYLOGENETIC ANALYSIS; CAUSATIVE AGENT; QUESTING
ADULT; HENSELAE; SPP.; INFECTION
AB A total of 42 ticks comprising Ixodes tasmani (n = 41) and Ixodes trichosuri (n = 1) were collected from wild koalas (Phascolarctos cinereus) at the Koala Convention Centre, Philip Island, Victoria, Australia and screened for the presence of Bartonella using the target gene gltA. Bartonella-like DNA was detected in 4 of the 19 pooled tick samples (21%). All positive ticks were male. Analysis of partial sequences for the gltA gene indicated the presence of a Bartonella-related species similar to that reported in another Ixodid species. This is the first report of Bartonella-like organisms in a native Australian marsupial.
C1 [Old, Julie M.] Univ Western Sydney, Sch Nat Sci, Penrith, NSW 1797, Australia.
[Vilcins, Inger-Marie E.] Macquarie Univ, Div Environm & Life Sci, Dept Biol Sci, N Ryde, NSW, Australia.
[Kosoy, Michael] Ctr Dis Control & Prevent, Ft Collins, CO USA.
[Deane, Elizabeth M.] Australian Natl Univ, Canberra, ACT 0200, Australia.
RP Old, JM (reprint author), Univ Western Sydney, Sch Nat Sci, Bldg K2,Hawkesbury Campus,Locked Bag 1797, Penrith, NSW 1797, Australia.
EM Elizabeth.deane@anu.edu.au
FU Macquarie University Postgraduate scholarship
FX This research was supported by a Macquarie University Postgraduate
scholarship to Vilcins.
NR 35
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U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD OCT
PY 2009
VL 9
IS 5
BP 499
EP 503
DI 10.1089/vbz.2008.0132
PG 5
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 507OO
UT WOS:000270864200008
PM 19271994
ER
PT J
AU Nett, RJ
Campbell, GL
Reisen, WK
AF Nett, R. J.
Campbell, G. L.
Reisen, W. K.
TI Potential for the Emergence of Japanese Encephalitis Virus in California
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Aedes; Epidemiology; Arbovirus; Culex; Mosquito; West Nile; Vector-borne
ID WEST-NILE-VIRUS; HOST-FEEDING PATTERNS; SOUTHERN CALIFORNIA;
AEDES-ALBOPICTUS; CULEX-TARSALIS; EXPERIMENTAL-INFECTION; NORTHERN
CALIFORNIA; DIPTERA-CULICIDAE; MOSQUITOS DIPTERA; VECTOR COMPETENCE
AB The potential risk for the introduction and establishment of Japanese encephalitis virus (JEV) within California is described based on the literature. JEV is a mosquito-borne arbovirus endemic to Asia that when transmitted to humans can lead to Japanese encephalitis (JE), a disease affecting mostly children with a fatality rate up to 30%. The geographical expansion of JEV in Asia along with the recent introduction and rapid spread of West Nile virus (WNV) across the United States, demonstrates the ability of arboviruses to rapidly extend their distributions. California is at particular risk for the introduction of JEV because it is a large state functioning as a hub for international travel and commerce with Asia, potentially allowing the introduction of mosquitoes infected with JEV. If JEV is introduced into California, the virus might become established due to the significant number of susceptible mosquito vectors and vertebrate hosts. Once introduced, the lack of active surveillance for JEV, the ambiguous clinical presentation of JE, the cross reactivity of serological testing between JEV and other flaviviruses, and the probability that clinicians and laboratories would not consider JE as a possible diagnosis would likely delay recognition. A significant delay in detection of JEV in California would make control and eradication of the virus very difficult and costly. Public health authorities should consider the need for future control efforts if JEV emerges in the United States.
C1 [Campbell, G. L.] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Vector Borne Infect Dis, Ft Collins, CO USA.
[Nett, R. J.] Ctr Dis Control & Prevent, Idaho Dept Hlth & Welf OEFP, Boise, ID 83720 USA.
[Nett, R. J.] 90th Med Grp, Flight Med Clin, Fe Warren AFB, WY USA.
[Reisen, W. K.] Univ Calif Davis, Sch Vet Med, Ctr Vectorborne Dis, Davis, CA 95616 USA.
RP Nett, RJ (reprint author), Ctr Dis Control & Prevent, Idaho Dept Hlth & Welf OEFP, 450 W State St,4th Floor, Boise, ID 83720 USA.
EM gge5@cdc.gov
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U1 3
U2 7
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD OCT
PY 2009
VL 9
IS 5
BP 511
EP 517
DI 10.1089/vbz.2008.0052
PG 7
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 507OO
UT WOS:000270864200010
PM 18973447
ER
PT J
AU Ulloa, A
Ferguson, HH
Mendez-Sanchez, JD
Danis-Lozano, R
Casas-Martinez, M
Bond, JG
Garcia-Zebadua, JC
Orozco-Bonilla, A
Juarez-Ordaz, JA
Farfan-Ale, JA
Garcia-Rejon, JE
Rosado-Paredes, EP
Edwards, E
Komar, N
Hassan, HK
Unnasch, TR
Rodriguez-Perez, MA
AF Ulloa, Armando
Hann Ferguson, Heidy
Mendez-Sanchez, Jose D.
Danis-Lozano, Rogelio
Casas-Martinez, Mauricio
Guillermo Bond, J.
Garcia-Zebadua, Julio C.
Orozco-Bonilla, Arnoldo
Juarez-Ordaz, Jose A.
Farfan-Ale, Jose A.
Garcia-Rejon, Julian E.
Rosado-Paredes, Elsy P.
Edwards, Eric
Komar, Nicholas
Hassan, Hassan K.
Unnasch, Thomas R.
Rodriguez-Perez, Mario A.
TI West Nile Virus Activity in Mosquitoes and Domestic Animals in Chiapas,
Mexico
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Aedes; Zoonosis; Arbovirus(es); Mosquito(es); West Nile; Anopheles;
Dengue; Entomology; Culex; Black fly (flies); Epidemiology;
Vector-borne; Birds
ID SEROLOGIC EVIDENCE; CULEX-NIGRIPALPUS; YUCATAN-STATE; INFECTION; HORSES;
SURVEILLANCE; TRANSMISSION; BIRDS
AB Prior to 2006, West Nile virus (WNV) had not been definitively detected in Chiapas, the southernmost state of Mexico, although it circulates elsewhere in Mexico and Central America. We collected over 30,000 mosquitoes and blood-sampled 351 domestic animals in Chiapas in search for evidence of current or recent transmission of WNV. Two mosquito pools tested positive for WNV RNA and 17 domestic animals tested positive for specific WNV-neutralizing antibodies, including young animals (<1 year old) in four of five sampled locations. The two WNV-positive mosquito pools were collected on the Pacific coastal plain of Chiapas in June, 2006, and included a pool of Culex nigripalpus, a suspected vector of WNV, and a pool of Cx. interrogator. The sequence of a 537-nucleotide portion of a cDNA amplicon derived from the WNV NS5 gene from the Cx. interrogator pool contained a single silent nucleotide substitution when compared to WNV strain NY99.
C1 [Ulloa, Armando; Mendez-Sanchez, Jose D.; Danis-Lozano, Rogelio; Casas-Martinez, Mauricio; Guillermo Bond, J.; Orozco-Bonilla, Arnoldo; Juarez-Ordaz, Jose A.] Ctr Reg Invest Salud Publ, Tapachula 30700, Chiapas, Mexico.
[Hann Ferguson, Heidy; Rodriguez-Perez, Mario A.] Inst Politecn Nacl, Ctr Biotecnol, Cd Reynosa, Tamaulipas, Mexico.
[Garcia-Zebadua, Julio C.] Univ Autonoma Chiapas, Fac Ciencias Quim UNACH, Tapachula, Chiapas, Mexico.
[Farfan-Ale, Jose A.; Garcia-Rejon, Julian E.; Rosado-Paredes, Elsy P.] Univ Autunoma Yucatan, Ctr Invest Reg, Merida, Yucatan, Mexico.
[Edwards, Eric; Komar, Nicholas] Ctr Dis Control & Prevent, Arbovirus Dis Branch, Ft Collins, CO USA.
[Hassan, Hassan K.; Unnasch, Thomas R.] Univ Alabama, Gorgas Ctr Geog Med, Birmingham, AL USA.
RP Ulloa, A (reprint author), Ctr Reg Invest Salud Publ, 19 Calle Poniente S-N Entre 4Ta & 6Ta Ave,Norte C, Tapachula 30700, Chiapas, Mexico.
EM aulloa@insp.mx
RI Rodriguez-Perez, Mario/P-8814-2014; Garcia-Rejon, Julian
Everardo/E-4285-2017
OI Rodriguez-Perez, Mario/0000-0002-0905-6073; Garcia-Rejon, Julian
Everardo/0000-0002-6681-1581
FU COCYTECH [CHIS-2005-C03-083]; Mexican National Institute of Public
Health; Comision de Operacion y Fomento de Actividades
Academicas/Instituto Politecnico Nacional
FX This project was partially funded by COCYTECH with grant
CHIS-2005-C03-083 and by the Mexican National Institute of Public
Health. Mario A. Rodriguez-Perez is supported by a scholarship from the
Comision de Operacion y Fomento de Actividades Academicas/Instituto
Politecnico Nacional.
NR 19
TC 9
Z9 9
U1 1
U2 10
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD OCT
PY 2009
VL 9
IS 5
BP 555
EP 560
DI 10.1089/vbz.2008.0087
PG 6
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 507OO
UT WOS:000270864200015
PM 19281433
ER
PT J
AU Reichard, MV
Roman, RM
Kocan, KM
Blouin, EF
de la Fuente, J
Snider, TA
Heinz, RE
West, MD
Little, SE
Massung, RF
AF Reichard, Mason V.
Roman, Raul Manzano
Kocan, Katherine M.
Blouin, Edmour F.
de la Fuente, Jose
Snider, Timothy A.
Heinz, Rebecca E.
West, Misti D.
Little, Susan E.
Massung, Robert F.
TI Inoculation of White-Tailed Deer (Odocoileus Virginianus) with Ap-V1 Or
NY-18 Strains of Anaplasma Phagocytophilum and Microscopic Demonstration
of Ap-V1 In Ixodes Scapularis Adults that Acquired Infection from Deer
as Nymphs
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Parasitology; Anaplasma; Tick; Vector-borne
ID EHRLICHIA-PHAGOCYTOPHILA; RESERVOIR HOSTS; MARGINALE; MICE;
RICKETTSIALES; CONNECTICUT; CHAFFEENSIS; AGENT
AB Four white-tailed deer were inoculated with either the Ap-V1 or NY-18 strain of Anaplasma phagocytophilum. Ixodes scapularis nymphs were then allowed to acquistion feed on the inoculated deer and molt to adults. Only an Ap-V1 infected deer was infected persistently and able to infect nymphal Ixodes scapularis. Molted adult ticks maintained Ap-V1 infection as demonstrated by PCR and microscopy. We report, for the first time, a morphologic description of A. phagocytophilum in I. scapularis.
C1 [Reichard, Mason V.; Roman, Raul Manzano; Kocan, Katherine M.; Blouin, Edmour F.; de la Fuente, Jose; Snider, Timothy A.; Heinz, Rebecca E.; West, Misti D.; Little, Susan E.] Oklahoma State Univ, Ctr Vet Hlth Sci, Dept Vet Pathobiol, Stillwater, OK 74078 USA.
[de la Fuente, Jose] CSIC UCLM JCCM, Inst Invest Recursos Cineget IRE, Ciudad Real, Spain.
[Massung, Robert F.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Div Viral & Rickettsial Dieseases, Atlanta, GA USA.
RP Reichard, MV (reprint author), Oklahoma State Univ, Ctr Vet Hlth Sci, Dept Vet Pathobiol, Stillwater, OK 74078 USA.
EM mason.reichard@okstate.edu
OI de la Fuente, Jose/0000-0001-7383-9649
FU Center for Veterinary Health Sciences, Oklahoma State University [1669];
Sitlington Endowed Chair for Food Animal Research
FX The present project was funded by the Center for Veterinary Health
Sciences, Oklahoma State University, project No. 1669 of the Oklahoma
Agricultural Experiment Station, and the Sitlington Endowed Chair for
Food Animal Research (K. M. Kocan). The authors thank Angie Bruner,
Krissy Gray, Dollie Clawson, Amanda Loftis, and Marina Eremeeva for
technical assistance and Laboratory Animal Resources Unit of Oklahoma
State University for assistance with maintenance of the deer.
NR 18
TC 19
Z9 19
U1 0
U2 10
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD OCT
PY 2009
VL 9
IS 5
BP 565
EP 568
DI 10.1089/vbz.2008.0106
PG 4
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 507OO
UT WOS:000270864200017
PM 18973438
ER
PT J
AU Glaser, V
Collins, WE
AF Glaser, Vicki
Collins, William E.
TI Interview with the Expert: William E. Collins, Ph.D.
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Editorial Material
C1 [Glaser, Vicki] Ctr Dis Control & Prevent, Senior Biomed Res Serv, Malaria Branch, Atlanta, GA 30333 USA.
[Collins, William E.] Biol Warfare Res Labs, Ft Detrick, MD USA.
[Collins, William E.] Publ Hlth Lab Serv, London, England.
RP Glaser, V (reprint author), Ctr Dis Control & Prevent, Senior Biomed Res Serv, Malaria Branch, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD OCT
PY 2009
VL 9
IS 5
BP 569
EP 572
DI 10.1089/vbz.2009.1500.int
PG 4
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 507OO
UT WOS:000270864200018
ER
PT J
AU Ford, ES
Li, CY
Zhao, GX
Pearson, WS
Capewell, S
AF Ford, Earl S.
Li, Chaoyang
Zhao, Guixiang
Pearson, William S.
Capewell, Simon
TI Trends in the Prevalence of Low Risk Factor Burden for Cardiovascular
Disease Among United States Adults
SO CIRCULATION
LA English
DT Article
DE cardiovascular diseases; epidemiology; population; prevention; risk
factors
ID HEALTHY LIFE-STYLE; CORONARY-HEART-DISEASE; PRIMARY PREVENTION; FACTOR
PROFILE; MIDDLE-AGE; WOMEN; MEN; MORTALITY; HYPERTENSION; POPULATION
AB Background-Cohorts consistently show that individuals with low levels of cardiovascular risk factors experience low rates of subsequent cardiovascular events. Our objective was to examine the prevalence and trends in low risk factor burden for cardiovascular disease among adults in the US population.
Methods and Results-We used data from adults 25 to 74 years of age who participated in 4 national surveys. We created an index of low risk from the following variables: not currently smoking, total cholesterol < 5.17 mmol/L (< 200 mg/dL) and not using cholesterol-lowering medications, systolic blood pressure < 120 mm Hg and diastolic blood pressure < 80 mm Hg and not using antihypertensive medications, body mass index < 25 kg/m(2), and not having been previously diagnosed with diabetes mellitus. The age-adjusted prevalence of low risk factor burden increased from 4.4% during 1971 to 1975 to 10.5% during 1988 to 1994 before decreasing to 7.5% during 1999 to 2004 (P for nonlinear trend <0.001). The patterns were similar for men and women, although the prevalence among women exceeded that among men in each survey (P<0.001 for each survey). In addition, whites had a significantly higher prevalence of low risk factor burden than blacks during each survey except during 1976 to 1980 (1971 to 1975, 1988 to 1994, 1999 to 2004: P<0.001; 1976 to 1980: P=0.154). Furthermore, a larger percentage of whites had a low risk factor burden than Mexican Americans during 1988 to 1994 (P<0.001) and 1999 to 2004 (P=0.001).
Conclusions-The prevalence of low risk factor burden for cardiovascular disease is low. The progress that had been made during the 1970s and 1980s reversed in recent decades. (Circulation. 2009; 120: 1181-1188.)
C1 [Ford, Earl S.; Li, Chaoyang; Zhao, Guixiang; Pearson, William S.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Capewell, Simon] Univ Liverpool, Div Publ Hlth, Liverpool L69 3BX, Merseyside, England.
RP Ford, ES (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,MS K66, Atlanta, GA 30341 USA.
EM eford@cdc.gov
FU Medical Research Council [G0900847]
NR 34
TC 59
Z9 60
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD SEP 29
PY 2009
VL 120
IS 13
BP 1181
EP 1188
DI 10.1161/CIRCULATIONAHA.108.835728
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 500AU
UT WOS:000270270200004
PM 19752328
ER
PT J
AU Merz, CNB
Alberts, MJ
Balady, GJ
Ballantyne, CM
Berra, K
Black, HR
Blumenthal, RS
Davidson, MH
Fazio, SB
Ferdinand, KC
Fine, LJ
Fonseca, V
Franklin, BA
McBride, PE
Mensah, GA
Merli, GJ
O'Gara, PT
Thompson, PD
Underberg, JA
AF Merz, C. Noel Bairey
Alberts, Mark J.
Balady, Gary J.
Ballantyne, Christie M.
Berra, Kathy
Black, Henry R.
Blumenthal, Roger S.
Davidson, Michael H.
Fazio, Sara B.
Ferdinand, Keith C.
Fine, Lawrence J.
Fonseca, Vivian
Franklin, Barry A.
McBride, Patrick E.
Mensah, George A.
Merli, Geno J.
O'Gara, Patrick T.
Thompson, Paul D.
Underberg, James A.
CA ACCF AHA ACP
TI ACCF/AHA/ACP 2009 Competence and Training Statement: A Curriculum on
Prevention of Cardiovascular Disease A Report of the American College of
Cardiology Foundation/American Heart Association/American College of
Physicians Task Force on Competence and Training (Writing Committee to
Develop a Competence and Training Statement on Prevention of
Cardiovascular Disease)
SO CIRCULATION
LA English
DT Editorial Material
DE ACCF/AHA Competence and Training Statements; competency; prevention;
cardiovascular; training; vascular; cardiac; cardiac rehabilitation
ID CORONARY-ARTERY-DISEASE; ACUTE MYOCARDIAL-INFARCTION; HEALTH-CARE
PROFESSIONALS; RANDOMIZED CONTROLLED-TRIAL; LIPID-LOWERING THERAPY;
HIGH-BLOOD-PRESSURE; INTERDISCIPLINARY WORKING GROUP;
STROKE-STATISTICS-SUBCOMMITTEE; 64-SLICE COMPUTED-TOMOGRAPHY;
SUSTAINED-RELEASE BUPROPION
C1 [Merz, C. Noel Bairey; Ballantyne, Christie M.; Blumenthal, Roger S.; McBride, Patrick E.] Amer Coll, Cardiol Fdn, Bryn Mawr, PA 19010 USA.
[Alberts, Mark J.] Amer Acad Neurol, St Paul, MN USA.
[Black, Henry R.] Amer Soc Hypertens, New York, NY 10016 USA.
[Fazio, Sara B.; Merli, Geno J.] Amer Coll Physicians, Philadelphia, PA 19106 USA.
[Ferdinand, Keith C.] Assoc Black Cardiologists, Atlanta, GA 30308 USA.
[Fine, Lawrence J.] NHLBI, Bethesda, MD USA.
[Fonseca, Vivian] Amer Diabet Assoc, Alexandria, VA USA.
[Franklin, Barry A.; O'Gara, Patrick T.] Amer Heart Assoc, Dallas, TX USA.
[Fine, Lawrence J.; Mensah, George A.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Thompson, Paul D.] Amer Coll Sports Med, Indianapolis, IN USA.
[Underberg, James A.] Amer Coll Prevent Med, Washington, DC USA.
[Fine, Lawrence J.; Mensah, George A.] NIH, Bethesda, MD USA.
RP Merz, CNB (reprint author), Amer Coll, Cardiol Fdn, Bryn Mawr, PA 19010 USA.
NR 223
TC 17
Z9 19
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD SEP 29
PY 2009
VL 120
IS 13
BP E100
EP E126
DI 10.1161/CIRCULATIONAHA.109.192640
PG 27
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 500AU
UT WOS:000270270200021
ER
PT J
AU Redberg, RF
Benjamin, EJ
Bittner, V
Braun, LT
Goff, DC
Havas, S
Labarthe, DR
Limacher, MC
Lloyd-Jones, DM
Mora, S
Pearson, TA
Radford, MJ
Smetana, GW
Spertus, JA
Swegler, EW
AF Redberg, Rita F.
Benjamin, Emelia J.
Bittner, Vera
Braun, Lynne T.
Goff, David C., Jr.
Havas, Stephen
Labarthe, Darwin R.
Limacher, Marian C.
Lloyd-Jones, Donald M.
Mora, Samia
Pearson, Thomas A.
Radford, Martha J.
Smetana, Gerald W.
Spertus, John A.
Swegler, Erica W.
CA ACCF AHA
TI ACCF/AHA 2009 Performance Measures for Primary Prevention of
Cardiovascular Disease in Adults
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Editorial Material
DE ACCF/AHA Performance Measures; prevention; cardiovascular disease
ID CORONARY-HEART-DISEASE; RANDOMIZED CONTROLLED-TRIALS;
COLLEGE-OF-CARDIOLOGY; SERVICES TASK-FORCE; RISK-FACTOR PROFILE;
MIDDLE-AGED ADULTS; BLOOD-PRESSURE; MYOCARDIAL-INFARCTION;
AMERICAN-COLLEGE; LIFE-STYLE
C1 [Labarthe, Darwin R.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Heart Dis & Stroke Prevent, Atlanta, GA 30333 USA.
RI Lloyd-Jones, Donald/C-5899-2009
NR 103
TC 58
Z9 61
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD SEP 29
PY 2009
VL 54
IS 14
BP 1364
EP 1405
DI 10.1016/j.jacc.2009.08.005
PG 42
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA 497SO
UT WOS:000270082700019
PM 19778679
ER
PT J
AU Pourrut, X
Souris, M
Towner, JS
Rollin, PE
Nichol, ST
Gonzalez, JP
Leroy, E
AF Pourrut, Xavier
Souris, Marc
Towner, Jonathan S.
Rollin, Pierre E.
Nichol, Stuart T.
Gonzalez, Jean-Paul
Leroy, Eric
TI Large serological survey showing cocirculation of Ebola and Marburg
viruses in Gabonese bat populations, and a high seroprevalence of both
viruses in Rousettus aegyptiacus
SO BMC INFECTIOUS DISEASES
LA English
DT Article
ID ZAIRE-EBOLAVIRUS; FRUIT BATS; TRANSMISSION; FILOVIRUSES; RESERVOIRS;
DISEASE
AB Background: Ebola and Marburg viruses cause highly lethal hemorrhagic fevers in humans. Recently, bats of multiple species have been identified as possible natural hosts of Zaire ebolavirus (ZEBOV) in Gabon and Republic of Congo, and also of marburgvirus (MARV) in Gabon and Democratic Republic of Congo.
Methods: We tested 2147 bats belonging to at least nine species sampled between 2003 and 2008 in three regions of Gabon and in the Ebola epidemic region of north Congo for IgG antibodies specific for ZEBOV and MARV.
Results: Overall, IgG antibodies to ZEBOV and MARV were found in 4% and 1% of bats, respectively. ZEBOV-specific antibodies were found in six bat species (Epomops franqueti, Hypsignathus monstrosus, Myonycteris torquata, Micropteropus pusillus, Mops condylurus and Rousettus aegyptiacus), while MARV-specific antibodies were only found in Rousettus aegyptiacus and Hypsignathus monstrosus. The prevalence of MARV-specific IgG was significantly higher in R. aegyptiacus members captured inside caves than elsewhere. No significant difference in prevalence was found according to age or gender. A higher prevalence of ZEBOV-specific IgG was found in pregnant females than in non pregnant females.
Conclusion: These findings confirm that ZEBOV and MARV co-circulate in Gabon, the only country where bats infected by each virus have been found. IgG antibodies to both viruses were detected only in Rousettus aegyptiacus, suggesting that this bat species may be involved in the natural cycle of both Marburg and Ebola viruses. The presence of MARV in Gabon indicates a potential risk for a first human outbreak. Disease surveillance should be enhanced in areas near caves.
C1 [Pourrut, Xavier; Souris, Marc; Leroy, Eric] Inst Rech Dev, UR 178, Marseille, France.
[Pourrut, Xavier; Gonzalez, Jean-Paul; Leroy, Eric] Ctr Int Rech Med Franceville, Franceville, Gabon.
[Souris, Marc] Mahidol Univ Salaya, Inst Rech Dev, UR 178, Nakhonpathon 73170, Thailand.
[Towner, Jonathan S.; Rollin, Pierre E.; Nichol, Stuart T.] Ctr Dis Control & Prevent, Special Pathogens Branch, Atlanta, GA USA.
RP Pourrut, X (reprint author), Inst Rech Dev, UR 178, Marseille, France.
EM xavier.pourrut@ird.fr; fnmsr@diamond.mahidol.ac.th; jit8@cdc.gov;
pyr3@cdc.gov; stn1@CDC.GOV; Jean-paul.gonzalez@ird.fr; eric.leroy@ird.fr
RI SOURIS, Marc/K-2506-2016; LEROY, Eric/I-4347-2016;
OI SOURIS, Marc/0000-0002-2933-3488; LEROY, Eric/0000-0003-0022-0890;
Gonzalez, Jean-Paul/0000-0003-3063-1770
FU Ministere des Affaires Etrangeres de la France (FSP) [2002005700]
FX CIRMF is supported by the Government of Gabon, Total-Fina-Elf Gabon, and
Ministere de la Cooperation Francaise. This work was also supported by a
Fonds de Solidarite Prioritaire grant from Ministere des Affaires
Etrangeres de la France (FSP no 2002005700).
NR 19
TC 105
Z9 110
U1 6
U2 60
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD SEP 28
PY 2009
VL 9
AR 159
DI 10.1186/1471-2334-9-159
PG 10
WC Infectious Diseases
SC Infectious Diseases
GA 512FR
UT WOS:000271232200001
PM 19785757
ER
PT J
AU Goodson, JL
Wiesen, E
Perry, RT
Mach, O
Kitambi, M
Kibona, M
Luman, ET
Cairns, KL
AF Goodson, James L.
Wiesen, Eric
Perry, Robert T.
Mach, Ondrej
Kitambi, Mary
Kibona, Mary
Luman, Elizabeth T.
Cairns, K. Lisa
TI Impact of measles outbreak response vaccination campaign in Dar es
Salaam, Tanzania
SO VACCINE
LA English
DT Article
DE Measles; Outbreak; Vaccination; Immunization
ID MORTALITY REDUCTION; AFRICAN REGION; IMMUNIZATION; COMMUNITY; EPIDEMICS;
PROGRESS
AB We assessed the impact of a measles outbreak response vaccination campaign (ORV) in Dar es Salaam, Tanzania. Age-specific incidence rates were calculated before and after the ORV. Incidence rate ratios for the two time periods were compared and used to estimate expected cases and deaths prevented by ORV. The ratio of measles incidence rates in the age groups targeted and not targeted by ORV decreased from 5.8 prior to ORV to 1.8 (p < 0.0001) after; 506 measles cases and 18 measles deaths were likely averted. These results support the need for revised recommendations concerning ORV in general settings in Africa. Published by Elsevier Ltd.
C1 [Goodson, James L.] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA 30333 USA.
RP Goodson, JL (reprint author), Ctr Dis Control & Prevent, Global Immunizat Div, 1600 Clifton Rd,NE,MS-E05, Atlanta, GA 30333 USA.
EM JGoodson@cdc.gov
FU Tanzania Ministry of Health; World Health Organization; United States
Centers for Disease Control and Prevention
FX This work was supported by the Tanzania Ministry of Health; World Health
Organization; and the United States Centers for Disease Control and
Prevention. The findings and conclusions in this report are those of the
authors and do not necessarily represent the official position of the
CDC. The authors would like to thank Dr. Balcha Masresha, Dr. Vance
Dietz, and Dr. Peter Strebel for their guidance and support during this
study; and acknowledge the hard work and remarkable achievements of the
Tanzania Ministry of Health surveillance officers and Dr. Deo Mtasiwa,
Director General for Health.
NR 30
TC 10
Z9 10
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD SEP 25
PY 2009
VL 27
IS 42
BP 5870
EP 5874
DI 10.1016/j.vaccine.2009.07.057
PG 5
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 502ON
UT WOS:000270469900023
PM 19656496
ER
PT J
AU McDougal, JS
AF McDougal, J. Steven
TI BED estimates of HIV incidence must be adjusted
SO AIDS
LA English
DT Letter
ID CAPTURE ENZYME-IMMUNOASSAY
C1 Ctr Dis Control & Prevent, HIV Lab Branch, Div HIV AIDS, Atlanta, GA 30333 USA.
RP McDougal, JS (reprint author), Ctr Dis Control & Prevent, HIV Lab Branch, Div HIV AIDS, Mailstop A25,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM JSM3@cdc.gov
NR 5
TC 11
Z9 12
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0269-9370
J9 AIDS
JI Aids
PD SEP 24
PY 2009
VL 23
IS 15
BP 2064
EP 2065
DI 10.1097/QAD.0b013e32832eff6e
PG 2
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 502QP
UT WOS:000270475400020
PM 19755866
ER
PT J
AU Dobbins, M
Hanna, SE
Ciliska, D
Manske, S
Cameron, R
Mercer, SL
O'Mara, L
DeCorby, K
Robeson, P
AF Dobbins, Maureen
Hanna, Steven E.
Ciliska, Donna
Manske, Steve
Cameron, Roy
Mercer, Shawna L.
O'Mara, Linda
DeCorby, Kara
Robeson, Paula
TI A randomized controlled trial evaluating the impact of knowledge
translation and exchange strategies
SO IMPLEMENTATION SCIENCE
LA English
DT Review
ID PHYSICAL-ACTIVITY; HEALTH COMMUNICATION; CARDIOVASCULAR RISK; SYSTEMATIC
REVIEWS; DECISION-MAKERS; YOUNG FINNS; IMPLEMENTATION; CHILDREN;
TRACKING; FITNESS
AB Context: Significant resources and time are invested in the production of research knowledge. The primary objective of this randomized controlled trial was to evaluate the effectiveness of three knowledge translation and exchange strategies in the incorporation of research evidence into public health policies and programs.
Methods: This trial was conducted with a national sample of public health departments in Canada from 2004 to 2006. The three interventions, implemented over one year in 2005, included access to an online registry of research evidence; tailored messaging; and a knowledge broker. The primary outcome assessed the extent to which research evidence was used in a recent program decision, and the secondary outcome measured the change in the sum of evidence-informed healthy body weight promotion policies or programs being delivered at health departments. Mixed-effects models were used to test the hypotheses.
Findings: One hundred and eight of 141 (77%) health departments participated in this study. No significant effect of the intervention was observed for primary outcome (p < 0.45). However, for public health policies and programs (HPPs), a significant effect of the intervention was observed only for tailored, targeted messages (p < 0.01). The treatment effect was moderated by organizational research culture (e. g., value placed on research evidence in decision making).
Conclusion: The results of this study suggest that under certain conditions tailored, targeted messages are more effective than knowledge brokering and access to an online registry of research evidence. Greater emphasis on the identification of organizational factors is needed in order to implement strategies that best meet the needs of individual organizations.
C1 [Dobbins, Maureen; Hanna, Steven E.; Ciliska, Donna; O'Mara, Linda; DeCorby, Kara; Robeson, Paula] McMaster Univ, Sch Nursing, Hamilton, ON L8N 3Z5, Canada.
[Manske, Steve; Cameron, Roy] Univ Waterloo, Ctr Behav Res, Waterloo, ON N2L 3G1, Canada.
[Manske, Steve; Cameron, Roy] Univ Waterloo, Program Evaluat, Waterloo, ON N2L 3G1, Canada.
[Mercer, Shawna L.] Ctr Dis Control & Prevent, Guide Community Prevent Serv, Natl Ctr Hlth Mkt, Atlanta, GA USA.
RP Dobbins, M (reprint author), McMaster Univ, Sch Nursing, 1200 Main St W, Hamilton, ON L8N 3Z5, Canada.
EM dobbinsm@mcmaster.ca; hannas@mcmaster.ca; ciliska@mcmaster.ca;
manske@healthy.uwaterloo.ca; cameron@healthy.uwaterloo.ca; Zhi5@CDC.GOV;
omara@mcmaster.ca; decorbk@mcmaster.ca; robesp@mcmaster.ca
FU Canadian Institutes of Health Research [14126]; City of Hamilton Public
Health Services; Institut National De Sante Publique du Quebec
FX The authors gratefully acknowledge funding of the research project from
the Canadian Institutes of Health Research, file # 14126, and in-kind
support of the City of Hamilton Public Health Services and Institut
National De Sante Publique du Quebec. The authors also gratefully
acknowledge the support and guidance of Helen Thomas, Associate
Professor (now retired), McMaster University, to the initial grant
proposal and during the implementation of the study. The authors report
no funding-related or other conflicts of interest in this work. Maureen
Dobbins is a career scientist with the Ontario Ministry of Health and
Long-Term Care. Results expressed in this report are those of the
investigators and do not necessarily reflect the opinions or policies of
the Ontario Ministry of Health and Long-Term Care.
NR 115
TC 90
Z9 90
U1 3
U2 32
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1748-5908
J9 IMPLEMENT SCI
JI Implement. Sci.
PD SEP 23
PY 2009
VL 4
AR 61
DI 10.1186/1748-5908-4-61
PG 16
WC Health Care Sciences & Services; Health Policy & Services
SC Health Care Sciences & Services
GA 515FN
UT WOS:000271453300001
PM 19775439
ER
PT J
AU Lee, EA
Stone, GW
Mehran, R
McLaurin, BT
Cox, DA
Bertrand, ME
Lincoff, AM
Moses, JW
White, HD
Ohman, EM
Fahy, M
Hooper, C
Dangas, GD
AF Lee, Edwin A.
Stone, Gregg W.
Mehran, Roxana
McLaurin, Brent T.
Cox, David A.
Bertrand, Michel E.
Lincoff, A. Michael
Moses, Jeffrey W.
White, Harvey D.
Ohman, E. Magnus
Fahy, Martin
Hooper, Craig
Dangas, George D.
TI The Predictive Value of CRP on 30-Day and 1-Year Mortality in Acute
Coronary Syndromes: An Analysis from the ACUITY Trial
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Meeting Abstract
CT 21st Annual Transcatheter Cardiovascular Therapeutics Conference
CY SEP 21-25, 2009
CL San Francisco, CA
C1 [Lee, Edwin A.; Stone, Gregg W.; Mehran, Roxana; Moses, Jeffrey W.; Dangas, George D.] Columbia Univ, Med Ctr, New York, NY USA.
[Lee, Edwin A.; Stone, Gregg W.; Mehran, Roxana; Moses, Jeffrey W.; Fahy, Martin; Dangas, George D.] Cardiovasc Res Fdn, New York, NY USA.
[McLaurin, Brent T.] Anderson Heart, Anderson, SC USA.
[Cox, David A.] Lehigh Valley Hosp, Allentown, PA USA.
[Bertrand, Michel E.] Hop Cardiol, F-59037 Lille, France.
[Lincoff, A. Michael] Cleveland Clin Fdn, Cleveland, OH 44195 USA.
[White, Harvey D.] Auckland City Hosp, Auckland, New Zealand.
[Ohman, E. Magnus] Duke Univ, Med Ctr, Durham, NC USA.
[Hooper, Craig] Ctr Dis Control, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD SEP 21
PY 2009
VL 104
IS 6A
BP 108D
EP 108D
PG 1
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA 496NP
UT WOS:000269981600305
ER
PT J
AU Gimnig, JE
Slutsker, L
AF Gimnig, John E.
Slutsker, Laurence
TI House screening for malaria control
SO LANCET
LA English
DT Editorial Material
ID LARGE-SCALE
C1 [Gimnig, John E.; Slutsker, Laurence] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30341 USA.
RP Slutsker, L (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30341 USA.
EM laurence.slutsker@cdc.hhs.gov
NR 11
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
J9 LANCET
JI Lancet
PD SEP 19
PY 2009
VL 374
IS 9694
BP 954
EP 955
DI 10.1016/S0140-6736(09)61078-3
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 498PK
UT WOS:000270154100006
PM 19732948
ER
PT J
AU Balish, A
Warnes, CM
Wu, K
Barnes, N
Emery, S
Berman, L
Shu, B
Lindstrom, S
Xu, X
Uyeki, T
Shaw, M
Klimov, A
Villanueva, J
AF Balish, A.
Warnes, C. M.
Wu, K.
Barnes, N.
Emery, S.
Berman, L.
Shu, B.
Lindstrom, S.
Xu, X.
Uyeki, T.
Shaw, M.
Klimov, A.
Villanueva, J.
TI Evaluation of Rapid Influenza Diagnostic Tests for Detection of Novel
Influenza A (H1N1) Virus-United States, 2009 (Reprinted from MMWR, vol
58, pg 826-829, 2009)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Balish, A.; Warnes, C. M.; Wu, K.; Barnes, N.; Emery, S.; Berman, L.; Shu, B.; Lindstrom, S.; Xu, X.; Uyeki, T.; Shaw, M.; Klimov, A.; Villanueva, J.] CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Balish, A (reprint author), CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
NR 1
TC 2
Z9 2
U1 1
U2 2
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD SEP 16
PY 2009
VL 302
IS 11
BP 1163
EP 1164
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 494FR
UT WOS:000269797600012
ER
PT J
AU Gwinn, M
Guessous, I
Khoury, MJ
AF Gwinn, Marta
Guessous, Idris
Khoury, Muin J.
TI Invited Commentary: Genes, Environment, and Hybrid Vigor
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Editorial Material
DE case-control studies; DNA damage; DNA repair; genetic predisposition to
disease; lung neoplasms; oxoguanine glycosylase 1; human; smoking
ID LUNG-CANCER RISK; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCUS;
SEQUENCE VARIANTS; PUBLIC-HEALTH; DNA-REPAIR; SMOKING; EPIDEMIOLOGY;
GENETICS; POLYMORPHISMS
AB In the 1950s, case-control studies of smoking and lung cancer established a paradigm for epidemiologic studies of risk factors for chronic diseases. Since then, thousands of case-control studies have examined possible associations of countless risk factors with numerous diseases, rarely finding associations as strong or consistent as that of smoking with lung cancer. Recently, researchers have applied advances in molecular genetics to conduct candidate gene and genome-wide association studies of lung cancer. Skeptics among both epidemiologists and geneticists have argued that genomic research adds little value when most cases of disease can be attributed to a preventable exposure; however, well-conducted studies of gene-environment interactions that draw on data from more than 50 years of research in toxicology, pathophysiology, and behavioral science offer important models for the development of more comprehensive approaches to understanding the etiology of chronic diseases.
C1 [Gwinn, Marta; Guessous, Idris; Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30341 USA.
[Guessous, Idris] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
RP Gwinn, M (reprint author), Ctr Dis Control & Prevent, Off Publ Hlth Genom, 4770 Buford Highway,Mailstop K-89, Atlanta, GA 30341 USA.
EM mgwinn@cdc.gov
NR 44
TC 5
Z9 5
U1 2
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD SEP 15
PY 2009
VL 170
IS 6
BP 703
EP 707
DI 10.1093/aje/kwp221
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 491UX
UT WOS:000269606900005
PM 19671836
ER
PT J
AU Fricke, WF
McDermott, PF
Mammel, MK
Zhao, SH
Johnson, TJ
Rasko, DA
Fedorka-Cray, PJ
Pedroso, A
Whichard, JM
LeClerc, JE
White, DG
Cebula, TA
Ravel, J
AF Fricke, W. Florian
McDermott, Patrick F.
Mammel, Mark K.
Zhao, Shaohua
Johnson, Timothy J.
Rasko, David A.
Fedorka-Cray, Paula J.
Pedroso, Adriana
Whichard, Jean M.
LeClerc, J. Eugene
White, David G.
Cebula, Thomas A.
Ravel, Jacques
TI Antimicrobial Resistance-Conferring Plasmids with Similarity to
Virulence Plasmids from Avian Pathogenic Escherichia coli Strains in
Salmonella enterica Serovar Kentucky Isolates from Poultry
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID FOOD ANIMALS POSE; R64 THIN-PILUS; HUMAN HEALTH; GENOME SEQUENCE;
PUBLISHED DATA; DNA-SEQUENCE; O78 STRAIN; GENES; ANTIBIOTICS; PRODUCTS
AB Salmonella enterica, a leading cause of food-borne gastroenteritis worldwide, may be found in any raw food of animal, vegetable, or fruit origin. Salmonella serovars differ in distribution, virulence, and host specificity. Salmonella enterica serovar Kentucky, though often found in the food supply, is less commonly isolated from ill humans. The multidrug-resistant isolate S. Kentucky CVM29188, isolated from a chicken breast sample in 2003, contains three plasmids (146,811 bp, 101,461 bp, and 46,121 bp), two of which carry resistance determinants (pCVM29188_146 [strAB and tetRA] and pCVM29188_101 [bla(CMY-2) and sugE]). Both resistance plasmids were transferable by conjugation, alone or in combination, to S. Kentucky, Salmonella enterica serovar Newport, and Escherichia coli recipients. pCVM29188_146 shares a highly conserved plasmid backbone of 106 kb (>90% nucleotide identity) with two virulence plasmids from avian pathogenic Escherichia coli strains (pAPEC-O1-ColBM and pAPEC-O2-ColV). Shared avian pathogenic E. coli (APEC) virulence factors include iutA iucABCD, sitABCD, etsABC, iss, and iroBCDEN. PCR analyses of recent (1997 to 2005) S. Kentucky isolates from food animal, retail meat, and human sources revealed that 172 (60%) contained similar APEC-like plasmid backbones. Notably, though rare in human-and cattle-derived isolates, this plasmid backbone was found at a high frequency (50 to 100%) among S. Kentucky isolates from chickens within the same time span. Ninety-four percent of the APEC-positive isolates showed resistance to tetracycline and streptomycin. Together, our findings of a resistance-conferring APEC virulence plasmid in a poultry-derived S. Kentucky isolate and of similar resistance/virulence plasmids in most recent S. Kentucky isolates from chickens and, to lesser degree, from humans and cattle highlight the need for additional research in order to examine the prevalence and spread of combined virulence and resistance plasmids in bacteria in agricultural, environmental, and clinical settings.
C1 [Fricke, W. Florian; Rasko, David A.; Ravel, Jacques] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA.
[McDermott, Patrick F.; Zhao, Shaohua; White, David G.] US FDA, Ctr Vet Med, Laurel, MD 20708 USA.
[Mammel, Mark K.; Whichard, Jean M.] US FDA, Ctr Food Safety & Appl Nutr, Laurel, MD 20708 USA.
[Johnson, Timothy J.] Univ Minnesota, St Paul, MN 55108 USA.
[Fedorka-Cray, Paula J.] USDA ARS, Bacterial Epidemiol & Antimicrobial Resistance Re, Athens, GA 30605 USA.
[Pedroso, Adriana] Univ Georgia, Dept Populat Hlth, Athens, GA 30223 USA.
[Whichard, Jean M.] Ctr Dis Control & Prevent, Div Foodborne Bacterial & Mycot Dis, Atlanta, GA 30333 USA.
[Cebula, Thomas A.] Johns Hopkins Univ, Baltimore, MD 21218 USA.
RP Ravel, J (reprint author), Univ Maryland, Sch Med, Inst Genome Sci, 801 W Baltimore St, Baltimore, MD 21201 USA.
EM jravel@som.umaryland.edu
RI Ravel, Jacques/D-2530-2009;
OI Ravel, Jacques/0000-0002-0851-2233; David, Rasko/0000-0002-7337-7154
FU National Institute of Allergy and Infectious Diseases (NIAID)
[pCVM29188_146, pCVM29188_101, pCVM29188_46]; National Institutes of
Health, Department of Health and Human Services [N01-AI-30071]
FX The sequencing of pCVM29188_146, pCVM29188_101, and pCVM29188_46 was
supported with federal funds from the National Institute of Allergy and
Infectious Diseases (NIAID), National Institutes of Health, Department
of Health and Human Services, under NIAID contract N01-AI-30071.
NR 46
TC 74
Z9 76
U1 2
U2 18
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD SEP 15
PY 2009
VL 75
IS 18
BP 5963
EP 5971
DI 10.1128/AEM.00786-09
PG 9
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 491VF
UT WOS:000269608000025
PM 19648374
ER
PT J
AU Pollack, LA
Rowland, JH
Crammer, C
Stefanek, M
AF Pollack, Lori A.
Rowland, Julia H.
Crammer, Corinne
Stefanek, Michael
TI Introduction: Charting the Landscape of Cancer Survivors' Health-Related
Outcomes and Care
SO CANCER
LA English
DT Editorial Material
AB The field of cancer survivorship is characterized by a complex and rapidly evolving landscape. This supplement presents a series of data-driven articles selected to highlight the breadth of new knowledge in this area of the cancer control continuum that were presented at the Fourth Biennial Cancer Survivorship Research Conference in Atlanta, Georgia, June 2008. Included in the volume is research on the biobehavioral impact of cancer; studies on quality-of-life and economic outcomes; and work focused on caregivers, understudied populations, and healthcare providers. Cancer 2009;115(18 suppl):4265-9. Published 2009 by the American Cancer Society.
C1 [Pollack, Lori A.] Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, Dept Hlth & Human Serv, Atlanta, GA 30341 USA.
[Rowland, Julia H.] NCI, Off Canc Survivorship, Div Canc Control & Populat Sci, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
[Crammer, Corinne; Stefanek, Michael] Amer Canc Soc, Behav Res Ctr, Atlanta, GA 30329 USA.
RP Pollack, LA (reprint author), Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, Dept Hlth & Human Serv, 4770 Buford Hwy NE,Mailstop K55, Atlanta, GA 30341 USA.
EM lpollack@cdc.gov
NR 19
TC 11
Z9 13
U1 0
U2 1
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0008-543X
J9 CANCER
JI Cancer
PD SEP 15
PY 2009
VL 115
IS 18
BP 4265
EP 4269
DI 10.1002/cncr.24579
PG 5
WC Oncology
SC Oncology
GA 493CA
UT WOS:000269709500001
PM 19731347
ER
PT J
AU Pickering, LK
Baker, CJ
Freed, GL
Gall, SA
Grogg, SE
Poland, GA
Rodewald, LE
Schaffner, W
Stinchfield, P
Tan, L
Zimmerman, RK
Orenstein, WA
AF Pickering, Larry K.
Baker, Carol J.
Freed, Gary L.
Gall, Stanley A.
Grogg, Stanley E.
Poland, Gregory A.
Rodewald, Lance E.
Schaffner, William
Stinchfield, Patricia
Tan, Litjen
Zimmerman, Richard K.
Orenstein, Walter A.
TI Immunization Programs for Infants, Children, Adolescents, and Adults:
Clinical Practice Guidelines by the Infectious Diseases Society of
America
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Review
ID HEALTH-CARE WORKERS; DTP VACCINE LITIGATION; HEPATITIS-B INFECTION;
LONG-TERM-CARE; UNITED-STATES; INFLUENZA VACCINATION; MEDICAL SETTINGS;
TRANSPLANT RECIPIENTS; AIRBORNE TRANSMISSION; INFORMATION-SYSTEMS
AB Evidence-based guidelines for immunization of infants, children, adolescents, and adults have been prepared by an Expert Panel of the Infectious Diseases Society of America (IDSA). These updated guidelines replace the previous immunization guidelines published in 2002. These guidelines are prepared for health care professionals who care for either immunocompetent or immunocompromised people of all ages. Since 2002, the capacity to prevent more infectious diseases has increased markedly for several reasons: new vaccines have been licensed (human papillomavirus vaccine; live, attenuated influenza vaccine; meningococcal conjugate vaccine; rotavirus vaccine; tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis [Tdap] vaccine; and zoster vaccine), new combination vaccines have become available (measles, mumps, rubella and varicella vaccine; tetanus, diphtheria, and pertussis and inactivated polio vaccine; and tetanus, diphtheria, and pertussis and inactivated polio/Haemophilus influenzae type b vaccine), hepatitis A vaccines are now recommended universally for young children, influenza vaccines are recommended annually for all children aged 6 months through 18 years and for adults aged >= 50 years, and a second dose of varicella vaccine has been added to the routine childhood and adolescent immunization schedule. Many of these changes have resulted in expansion of the adolescent and adult immunization schedules. In addition, increased emphasis has been placed on removing barriers to immunization, eliminating racial/ethnic disparities, addressing vaccine safety issues, financing recommended vaccines, and immunizing specific groups, including health care providers, immunocompromised people, pregnant women, international travelers, and internationally adopted children. This document includes 46 standards that, if followed, should lead to optimal disease prevention through vaccination in multiple population groups while maintaining high levels of safety.
C1 [Pickering, Larry K.] Ctr Dis Control & Prevent, Advisory Comm Immunizat Practices, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Pickering, LK (reprint author), Ctr Dis Control & Prevent, Advisory Comm Immunizat Practices, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,Mailstop E-05, Atlanta, GA 30333 USA.
EM LPickering@cdc.gov
OI Tan, Litjen/0000-0001-9054-6696; Zimmerman, Richard/0000-0001-5941-6092;
Rodewald, Lance/0000-0003-2593-542X
FU Astellas; GlaxoSmithKline; Merck; Sanofi Pasteur; MedImmune; Wyeth;
member of Merck's Male Population Advisory Board; National Institute of
Health; Centers for Disease Control and Prevention; Novavax; Protein
Sciences; Novartis; CSL Limited; PowderMed; Avianax
FX S. A. G. serves as a consultant to the advisory boards and has received
research grants from Merck and GlaxoSmithKline and serves on the
speaker's bureaus of Merck, GlaxoSmithKline, Sanofi Pasteur, and the
Advisory Committee on Immunization Practices working group for Influenza
and HPV. S. E. G. has received research funding from Astellas,
GlaxoSmithKline, Merck, Sanofi Pasteur, MedImmune, and Wyeth; is a
member of Merck's Male Population Advisory Board for the HPV (Gardasil)
vaccine; and serves on the speaker's bureau for and has received
honoraria from Merck and AstraZeneca Pharmaceuticals. W. S. serves on
the Merck Data Safety Monitoring Board for Experimental Vaccines and has
received honoraria from Sanofi-Pasteur and MedImmune. G. A. P. has
received research grants from and serves as a consultant to the National
Institute of Health, the Centers for Disease Control and Prevention,
Novavax, Merck, Protein Sciences, GlaxoSmithKline, Novartis, CSL
Limited, PowderMed, and Avianax. R. Z. serves on the Data Safety
Monitoring Board, has received educational and research grants from
Merck, and is in contract negotiations with MedImmune. L.K.P., C.J.B.,
G.L.F, L.R., P.S., L.T., and W.A.O.: no conflicts.
NR 116
TC 63
Z9 69
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD SEP 15
PY 2009
VL 49
IS 6
BP 817
EP 840
DI 10.1086/605430
PG 24
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 485ST
UT WOS:000269145100001
PM 19659433
ER
PT J
AU Jones, JL
Dargelas, V
Roberts, J
Press, C
Remington, JS
Montoya, JG
AF Jones, Jeffrey L.
Dargelas, Valerie
Roberts, Jacquelin
Press, Cindy
Remington, Jack S.
Montoya, Jose G.
TI Risk Factors for Toxoplasma gondii Infection in the United States
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID TREATED CONGENITAL TOXOPLASMOSIS; SEA OTTERS; ACQUIRED TOXOPLASMOSIS;
TISSUE CYSTS; DIAGNOSIS; RETINOCHOROIDITIS; MANIFESTATIONS; ANTIBODIES;
MANAGEMENT; CHILDREN
AB Background. Toxoplasmosis can cause severe ocular and neurological disease. We sought to determine risk factors for Toxoplasma gondii infection in the United States.
Methods. We conducted a case-control study of adults recently infected with T. gondii. Case patients were selected from the Palo Alto Medical Foundation Toxoplasma Serology Laboratory from August 2002 through May 2007; control patients were randomly selected from among T. gondii-seronegative persons. Data were obtained from serological testing and patient questionnaires.
Results. We evaluated 148 case patients with recent T. gondii infection and 413 control patients. In multivariate analysis, an elevated risk of recent T. gondii infection was associated with the following factors: eating raw ground beef ( adjusted odds ratio [aOR], 6.67; 95% confidence limits [CLs], 2.09, 21.24; attributable risk [AR], 7%); eating rare lamb (aOR, 8.39; 95% CLs, 3.68, 19.16; AR, 20%); eating locally produced cured, dried, or smoked meat (aOR, 1.97; 95% CLs, 1.18, 3.28; AR, 22%); working with meat (aOR, 3.15; 95% CLs, 1.09, 9.10; AR, 5%); drinking unpasteurized goat's milk (aOR, 5.09; 95% CLs, 1.45, 17.80; AR, 4%); and having 3 or more kittens (aOR, 27.89; 95% CLs, 5.72, 135.86; AR, 10%). Eating raw oysters, clams, or mussels (aOR, 2.22; 95% CLs, 1.07, 4.61; AR, 16%) was significant in a separate model among persons asked this question. Subgroup results are also provided for women and for pregnant women.
Conclusions. In the United States, exposure to certain raw or undercooked foods and exposure to kittens are risk factors for T. gondii infection. Knowledge of these risk factors will help to target prevention efforts.
C1 [Jones, Jeffrey L.; Roberts, Jacquelin] Ctr Dis Control & Prevent, Div Parasit Dis, Coordinating Ctr Infect Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30341 USA.
[Dargelas, Valerie; Press, Cindy; Remington, Jack S.; Montoya, Jose G.] Palo Alto Med Fdn, Toxoplasma Serol Lab, Palo Alto, CA USA.
[Remington, Jack S.; Montoya, Jose G.] Stanford Univ, Dept Med, Sch Med, Div Infect Dis & Geog Med, Stanford, CA 94305 USA.
RP Jones, JL (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Coordinating Ctr Infect Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, 4770 Buford Hwy, Atlanta, GA 30341 USA.
EM jlj1@cdc.gov
FU Centers for Disease Control and Prevention
FX Centers for Disease Control and Prevention.
NR 40
TC 144
Z9 153
U1 1
U2 26
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD SEP 15
PY 2009
VL 49
IS 6
BP 878
EP 884
DI 10.1086/605433
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 485ST
UT WOS:000269145100008
PM 19663709
ER
PT J
AU Modi, S
Buff, AM
Lawson, CJ
Rodriguez, D
Kirking, HL
Lipman, H
Fishbein, DB
AF Modi, Surbhi
Buff, Ann M.
Lawson, Carl J.
Rodriguez, Daniel
Kirking, Hannah L.
Lipman, Harvey
Fishbein, Daniel B.
TI Reporting Patterns and Characteristics of Tuberculosis among
International Travelers, United States, June 2006 to May 2008
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID DRUG-RESISTANT TUBERCULOSIS; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY
TUBERCULOSIS; GLOBAL EPIDEMIOLOGY; AIR-TRAVEL; TRANSMISSION; ABOARD;
SHIP; QUARANTINE; OUTBREAK
AB Background. As part of efforts to prevent the introduction of communicable diseases into the United States, the Centers for Disease Control and Prevention (CDC) conducts surveillance for selected diseases in international travelers. One of these diseases, tuberculosis (TB), received substantial attention in May 2007 when the CDC issued travel restrictions and a federal isolation order for a person with drug-resistant TB who traveled internationally against public health recommendations.
Methods. Reports of TB in international travelers in the CDC's Quarantine Activity Reporting System (QARS) from 1 June 2006 through 31 May 2007 (year 1) were compared with reports from 1 June 2007 through 31 May 2008 (year 2). These reports were classified using the CDC and American Thoracic Society guidelines and analyzed for epidemiologic characteristics and trends.
Results. Among QARS reports, 4.6% were classified as active TB disease and 1.7% as no TB disease. Active TB disease reports increased from 2.5% of QARS reports in year 1 to 6.4% in year 2 (P < .001). The proportion P < .001 of active TB disease reports leading to a federal travel restriction increased from 6.8% in year 1 to 15.4% in year 2 (P = .08).
Conclusions. The significant increase in reports of international travelers with TB disease likely represents more attention to and a higher index of suspicion for TB. The increased use of federal travel restrictions was associated with the development of new procedures to limit travel for public health reasons. Continued efforts are needed to decrease the number of persons with TB who travel while potentially contagious.
C1 [Modi, Surbhi; Lawson, Carl J.; Rodriguez, Daniel; Kirking, Hannah L.; Lipman, Harvey; Fishbein, Daniel B.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA.
[Buff, Ann M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Off Workforce & Career Dev, Atlanta, GA 30333 USA.
[Kirking, Hannah L.] Ctr Dis Control & Prevent, Experience Appl Epidemiol Fellowship Program, Off Workforce & Career Dev, Atlanta, GA 30333 USA.
[Buff, Ann M.] Ctr Dis Control & Prevent, Div TB Eliminat, Natl Ctr HIV AIDS Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA.
[Modi, Surbhi] Emory Univ, Sch Med, Atlanta, GA USA.
RP Modi, S (reprint author), Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Natl Ctr Preparedness Detect & Control Infect Dis, 1600 Clifton Rd NE,MS E-04, Atlanta, GA 30333 USA.
EM smodi@cdc.gov
FU CDC Experience Applied Epidemiology Fellowship Program; CDC Foundation
from Pfizer
FX S.M., A.M.B., C.J.L., D.R., H.L. K., H.L., and D. B. F. are all employed
by the CDC. H. L. K. is a fellow in the CDC Experience Applied
Epidemiology Fellowship Program, which is a public-private partnership
supported jointly by the CDC and Pfizer via a grant to the CDC
Foundation from Pfizer.
NR 36
TC 6
Z9 6
U1 0
U2 1
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD SEP 15
PY 2009
VL 49
IS 6
BP 885
EP 891
DI 10.1086/605437
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 485ST
UT WOS:000269145100009
PM 19663563
ER
PT J
AU Patel, JB
Gorwitz, RJ
Jernigan, JA
AF Patel, Jean B.
Gorwitz, Rachel J.
Jernigan, John A.
TI Mupirocin Resistance
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID STAPHYLOCOCCUS-AUREUS INFECTIONS; RANDOMIZED CONTROLLED-TRIAL; CHRONIC
PERITONEAL-DIALYSIS; SOFT-TISSUE INFECTIONS; INTENSIVE-CARE-UNIT;
METHICILLIN-RESISTANT; HIGH-LEVEL; INTRANASAL MUPIROCIN; INTERPRETIVE
CRITERIA; NASAL MUPIROCIN
AB With increasing pressure to prevent methicillin-resistant Staphylococcus aureus (MRSA) infection, it is possible that there will be increased use of mupirocin for nasal decolonization of MRSA. Understanding the mechanisms, clinical significance, and epidemiology of mupirocin resistance is important for predicting how changes in mupirocin use may affect bacterial populations and MRSA control. High-level mupirocin resistance in S. aureus is mediated by a plasmid-encoded mupA gene. This gene can be found on conjugative plasmids that carry multiple resistance determinants for other classes of antimicrobial agents. High-level resistance has been associated with decolonization failure, and increased resistance rates have been associated with increased mupirocin use. Low-level mupirocin resistance is mediated via mutation in the native ileS gene, and the clinical significance of this resistance is unclear. Laboratory tests to detect and distinguish between these types of resistance have been described but are not widely available in the United States. Institutions that are considering the implementation of widespread mupirocin use should consider these resistance issues and develop strategies to monitor the impact of mupirocin use.
C1 [Patel, Jean B.; Gorwitz, Rachel J.; Jernigan, John A.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA.
RP Patel, JB (reprint author), Mailstop G-08,1600 Clifton Rd NE, Atlanta, GA 30333 USA.
EM jpatel1@cdc.gov
NR 66
TC 138
Z9 139
U1 0
U2 11
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD SEP 15
PY 2009
VL 49
IS 6
BP 935
EP 941
DI 10.1086/605495
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 485ST
UT WOS:000269145100018
PM 19673644
ER
PT J
AU Staples, JE
Breiman, RF
Powers, AM
AF Staples, J. Erin
Breiman, Robert F.
Powers, Ann M.
TI Chikungunya Fever: An Epidemiological Review of a Re-Emerging Infectious
Disease
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Review
ID VIRUS-INFECTION; REUNION ISLAND; INDIAN-OCEAN; AEDES-ALBOPICTUS; ADULT
PATIENTS; SOUTH-INDIA; RHEUMATIC MANIFESTATIONS; CLINICAL-FEATURES;
RISK-FACTORS; OUTBREAK
AB Chikungunya fever is an acute febrile illness associated with severe, often debilitating polyarthralgias. The disease is caused by Chikungunya virus (CHIKV), an arthropod-borne virus that is transmitted to humans primarily via the bite of an infected mosquito. Since a re-emergence of CHIKV in 2004, the virus has spread into novel locations, such as Europe, and has led to millions of cases of disease throughout countries in and around the Indian Ocean. The risk of importation of CHIKV into new areas is ever present because of the high attack rates associated with the recurring epidemics, the high levels of viremia in infected humans, and the worldwide distribution of the vectors responsible for transmitting CHIKV. In this review, we will characterize the epidemiology and global expansion of CHIKV, describe the clinical features and laboratory testing for the disease, and discuss priorities for further studies needed for effective disease control and prevention.
C1 [Staples, J. Erin; Powers, Ann M.] Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA.
[Breiman, Robert F.] Ctr Dis Control & Prevent, Int Emerging Infect Program Kenya, Nairobi, Kenya.
RP Staples, JE (reprint author), Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Infect Dis, 3150 Rampart Rd, Ft Collins, CO 80521 USA.
EM EStaples@cdc.gov
NR 85
TC 187
Z9 199
U1 2
U2 43
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD SEP 15
PY 2009
VL 49
IS 6
BP 942
EP 948
DI 10.1086/605496
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 485ST
UT WOS:000269145100019
PM 19663604
ER
PT J
AU Jhung, MA
Banerjee, SN
AF Jhung, Michael A.
Banerjee, Shailen N.
TI Administrative Coding Data and Health Care-Associated Infections
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID SURGICAL-SITE INFECTIONS; STAPHYLOCOCCUS-AUREUS INFECTIONS; HOSPITAL
DISCHARGE DIAGNOSES; BLOOD-STREAM INFECTIONS; UNITED-STATES;
METHICILLIN-RESISTANT; NOSOCOMIAL INFECTION; SURVEILLANCE SYSTEM;
IDENTIFICATION; VALIDATION
AB Surveillance for health care-associated infections (HAIs) using administrative data has received attention from health care epidemiologists searching for efficient means to track infections in their institutions. Several states are also considering electronic surveillance that incorporates administrative data as a means to satisfy an increasing demand for mandatory public reporting of HAIs. International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) discharge diagnosis codes have attributes that make them suitable for detecting HAIs; for example, they may facilitate automated surveillance, freeing up infection control personnel to perform other important tasks, such as staff education and outbreak investigation. However, controversy surrounds the appropriate use of ICD-9-CM data in detecting HAIs, and administrative coding data have been criticized for lacking elements necessary for surveillance. Administrative coding data are inappropriate as the sole means of HAI surveillance but may have value to the health care epidemiologist as a way to augment traditional methods.
C1 [Jhung, Michael A.; Banerjee, Shailen N.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
RP Jhung, MA (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE,MS A-31, Atlanta, GA 30333 USA.
EM mjhung@cdc.gov
NR 46
TC 47
Z9 47
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD SEP 15
PY 2009
VL 49
IS 6
BP 949
EP 955
DI 10.1086/605086
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 485ST
UT WOS:000269145100020
PM 19663692
ER
PT J
AU Blanton, JD
Robertson, K
Palmer, D
Rupprecht, CE
AF Blanton, Jesse D.
Robertson, Kis
Palmer, Dustyn
Rupprecht, Charles E.
TI Rabies surveillance in the United States during 2008
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Article
ID PUBLIC VETERINARY-MEDICINE; RACCOON RABIES; TERRESTRIAL CARNIVORES; ORAL
VACCINATION; NEW-JERSEY; VIRUS; WILDLIFE; EPIDEMIOLOGY; INFECTION;
EFFICACY
AB During 2008, 49 states and Puerto Rico reported 6,841 cases of rabies in animals and 2 cases in humans to the CDC, representing a 3.1% decrease from the 7,060 cases in animals and 1 case in a human reported in 2007 Approximately 93% of the cases were in wildlife, and 7% were in domestic animals. Relative contributions by the major animal groups were as follows: 2,389 (34.9%) raccoons, 1,806 (26.4%) bats, 1,589 (23.2%) skunks, 454 (6.6%) foxes, 294 (4.3%) cats, 75 (1.1%) dogs, and 59 (0.9%) cattle. Compared with numbers of cases reported in 2007, numbers of cases reported in 2008 increased among cats, cattle, and skunks and decreased among dogs, raccoons, bats, and foxes. Numbers of rabid raccoons reported during 2008 decreased in 11 of the 20 eastern states where raccoon rabies was enzootic; overall number of rabid raccoons reported decreased by 8.6% during 2008, compared with 2007.
On a national level, the number of rabies cases involving skunks increased by 77% during 2008, compared with the number reported in 2007; this was the first increase in the number of reported rabid skunks since 2006. The total number of cases of rabies reported nationally in foxes decreased 1.7% in 2008, compared with 2007. The 1,806 cases of rabies reported in bats represented a 6.7% decrease, compared with the number reported in 2007 One case of rabies in a dog imported from Iraq was reported at a quarantine station in New Jersey during 2008. Follow-up of potentially exposed animals in the same shipment did not reveal any secondary transmission. The United States remained free from clog-to-clog transmission of canine rabies virus variants. Total number of rabid dogs reported decreased 19.4% in 2008, compared with 2007.
Two human rabies cases were reported from California and Missouri during 2008. The California case involved a recent immigrant from Mexico and was attributed to a newly identified rabies virus variant most likely associated with Mexican free-tailed bats. The case in Missouri was attributed to a rabies virus variant associated with eastern pipistrelle and silver-haired bats.
C1 [Blanton, Jesse D.; Palmer, Dustyn; Rupprecht, Charles E.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis,Coordina, Atlanta, GA 30333 USA.
[Robertson, Kis] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA.
RP Blanton, JD (reprint author), Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis,Coordina, 1600 Clifton Rd NE, Atlanta, GA 30333 USA.
NR 67
TC 35
Z9 38
U1 1
U2 6
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD SEP 15
PY 2009
VL 235
IS 6
BP 676
EP 689
PG 14
WC Veterinary Sciences
SC Veterinary Sciences
GA 493YV
UT WOS:000269776600028
PM 19751163
ER
PT J
AU LeBaron, CW
Forghani, B
Matter, L
Reef, SE
Beck, C
Bi, DL
Cossen, C
Sullivan, BJ
AF LeBaron, Charles W.
Forghani, Bagher
Matter, Lukas
Reef, Susan E.
Beck, Carol
Bi, Daoling
Cossen, Cynthia
Sullivan, Bradley J.
TI Persistence of Rubella Antibodies after 2 Doses of Measles-Mumps-Rubella
Vaccine
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID IMMUNOGLOBULIN-M ANTIBODIES; CONGENITAL-RUBELLA; UNITED-STATES; ENZYME
IMMUNOASSAYS; MATERNAL REINFECTION; VIRUS; IMMUNITY; ELIMINATION;
CHALLENGE; SCHOOLCHILDREN
AB Background. Since 1990, most schoolchildren in the United States have received a second dose of measles-mumps-rubella vaccine (MMR2) at kindergarten entry. Elimination of endemic rubella virus circulation in the United States was declared in 2004. The objective of the current study was to evaluate the short- and long-term rubella immunogenicity of MMR2.
Methods. At enrollment in 1994-1995, children (n = 307) in a rural Wisconsin health maintenance organization received MMR2 at age 4-6 years. A comparison group of older children (n = 306) was vaccinated at age 9-11 years. Serum specimens were collected during a 12-year period. Rubella antibody levels were evaluated by plaque-reduction neutralization (lowest detectable titer, 1:10).
Results. Before administration of MMR2 in the kindergarten group, 9% of subjects were seronegative, 60% had the lowest detectable titer, and the geometric mean titer (GMT) was 1:13. One month after administration of MMR2, 1% were seronegative, 6% had the lowest detectable titer, and the GMT was 1:42. Four-fold boosts occurred in 62% of subjects, but only 0.3% were immunoglobulin M positive. Twelve years after MMR2 administration, 10% were seronegative, 43% had the lowest detectable titer, and the GMT was 1:17. The middle-school group showed similar patterns.
Conclusions. Rubella antibody response to MMR2 was vigorous, but titers decreased to pre-MMR2 levels after 12 years. Because rubella is a highly epidemic disease, vigilance will be required to assure continued elimination.
C1 [LeBaron, Charles W.; Reef, Susan E.; Bi, Daoling] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Forghani, Bagher; Cossen, Cynthia] Calif Dept Publ Hlth, Viral & Rickettsial Dis Lab Branch, Div Communicable Dis Control, Richmond, CA USA.
[Beck, Carol; Sullivan, Bradley J.] Marshfield Clin Fdn Med Res & Educ, Marshfield, WI 54449 USA.
[Matter, Lukas] Viollier, Div Immunol, Basel, Switzerland.
RP LeBaron, CW (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, MS A-47,16 Clifton Rd, Atlanta, GA 30333 USA.
EM clebaron@cdc.gov
NR 45
TC 24
Z9 25
U1 0
U2 1
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD SEP 15
PY 2009
VL 200
IS 6
BP 888
EP 899
DI 10.1086/605410
PG 12
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 484HF
UT WOS:000269034200009
PM 19659440
ER
PT J
AU Igietseme, JU
He, Q
Joseph, K
Eko, FO
Lyn, D
Ananaba, G
Campbell, A
Bandea, C
Black, CM
AF Igietseme, Joseph U.
He, Qing
Joseph, Kahaliah
Eko, Francis O.
Lyn, Deborah
Ananaba, Godwin
Campbell, Angela
Bandea, Claudiu
Black, Carolyn M.
TI Role of T Lymphocytes in the Pathogenesis of Chlamydia Disease
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID PELVIC-INFLAMMATORY-DISEASE; GENITAL-TRACT INFECTION; TRACHOMATIS;
IMMUNITY; CELLS; VACCINE; MICE; IMMUNIZATION; INFERTILITY; PROTECTION
AB Vaccines are needed to prevent the oculogenital diseases of Chlamydia trachomatis. Infected hosts develop immunity, although temporary, and experimental vaccines have yielded significant protective immunity in animal models, fueling the impetus for a vaccine. Because infections cause sequelae, the functional relationship between infection- and vaccine-induced immunity is unclear. We hypothesized that infection- and vaccine-induced immunity are functionally distinct, particularly in the ability to prevent sequelae. Chlamydia-immune mice, with immunity generated by either a previous infection or vaccination, exhibited a significant degree of protective immunity, marked by a lower-intensity, abbreviated course of infection. However, vaccinated mice were protected from infertility, whereas preinfected mice were not. Thus, infection- induced immunity does not prevent the pathologic process leading to infertility. Furthermore, T cell subsets, especially CD8 T cells, play a major role in Chlamydia-induced infertility. The results have important implications for the immunopathogenesis of chlamydial disease and new vaccine strategies.
C1 [Igietseme, Joseph U.; He, Qing; Joseph, Kahaliah; Bandea, Claudiu; Black, Carolyn M.] Morehouse Sch Med, Ctr Dis Control & Prevent, Atlanta, GA 30310 USA.
[Igietseme, Joseph U.; He, Qing; Eko, Francis O.; Lyn, Deborah] Morehouse Sch Med, Dept Microbiol Biochem & Immunol, Atlanta, GA 30310 USA.
[Ananaba, Godwin; Campbell, Angela] Clark Atlanta Univ, Atlanta, GA 30314 USA.
RP Igietseme, JU (reprint author), CDC, NCID, DSR, Mailstop C17,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM jigietseme@cdc.gov
FU National Institutes of Health and Centers for Disease Control and
Prevention [AI41231, GM 08248, RR03034]
FX National Institutes of Health and Centers for Disease Control and
Prevention (Public Health Service grants AI41231, GM 08248, and
RR03034). Reprints or correspondence: Dr. Igietseme, NCID/DSR/CDC,
Mailstop C17, 1600 Clifton Rd, Atlanta, GA 30333 (jigietseme@cdc.gov).
NR 47
TC 31
Z9 32
U1 0
U2 5
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD SEP 15
PY 2009
VL 200
IS 6
BP 926
EP 934
DI 10.1086/605411
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 484HF
UT WOS:000269034200013
PM 19656067
ER
PT J
AU Golden-Mason, L
Palmer, BE
Kassam, N
Townshend-Bulson, L
Livingston, S
McMahon, BJ
Castelblanco, N
Kuchroo, V
Gretch, DR
Rosen, HR
AF Golden-Mason, Lucy
Palmer, Brent E.
Kassam, Nasim
Townshend-Bulson, Lisa
Livingston, Stephen
McMahon, Brian J.
Castelblanco, Nicole
Kuchroo, Vijay
Gretch, David R.
Rosen, Hugo R.
TI Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis
C Virus Infection and Its Blockade Rescues Dysfunctional CD4(+) and
CD8(+) T Cells
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID ANTIVIRAL THERAPY; CD127 EXPRESSION; PD-1 EXPRESSION; FLOW-CYTOMETRY;
HCV INFECTION; EFFECTOR; LYMPHOCYTES; PHENOTYPE; FREQUENCIES; GALECTIN-9
AB A number of emerging molecules and pathways have been implicated in mediating the T-cell exhaustion characteristic of chronic viral infection. Not all dysfunctional T cells express PD-1, nor are they all rescued by blockade of the PD-1/PD-1 ligand pathway. In this study, we characterize the expression of T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) in chronic hepatitis C infection. For the first time, we found that Tim-3 expression is increased on CD4(+) and CD8(+) T cells in chronic hepatitis C virus (HCV) infection. The proportion of dually PD-1/Tim-3-expressing cells is greatest in liver-resident T cells, significantly more so in HCV-specific than in cytomegalovirus-specific cytotoxic T lymphocytes. Tim-3 expression correlates with a dysfunctional and senescent phenotype (CD127(low) CD57(high)), a central rather than effector memory profile (CD45RA(negative) CCR7(high)), and reduced Th1/Tc1 cytokine production. We also demonstrate the ability to enhance T-cell proliferation and gamma interferon production in response to HCV-specific antigens by blocking the Tim-3-Tim-3 ligand interaction. These findings have implications for the development of novel immunotherapeutic approaches to this common viral infection.
C1 [Golden-Mason, Lucy; Castelblanco, Nicole; Rosen, Hugo R.] Univ Colorado, Hlth Sci Ctr, Dept Med, Div Gastroenterol & Hepatol, Denver, CO 80262 USA.
[Golden-Mason, Lucy; Palmer, Brent E.; Castelblanco, Nicole; Rosen, Hugo R.] Natl Jewish Hosp, Denver, CO USA.
[Golden-Mason, Lucy; Castelblanco, Nicole; Rosen, Hugo R.] Denver VA Ctr, Denver, CO USA.
[Palmer, Brent E.] Univ Colorado, Hlth Sci Ctr, Div Clin Immunol, Denver, CO USA.
[Kassam, Nasim; Kuchroo, Vijay] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA.
[Townshend-Bulson, Lisa; Livingston, Stephen; McMahon, Brian J.] Liver Dis & Hepatitis Program, Alaska Native Tribal Hlth Consortium, Anchorage, AK USA.
[McMahon, Brian J.] Ctr Dis Control & Prevent, Arctic Invest Program, Div Emerging Infect & Surveillance Serv, Natl Ctr Preparedness Detect & Control Infect Dis, Anchorage, AK USA.
[Gretch, David R.] Univ Washington, Div Lab Med, Seattle, WA 98195 USA.
RP Rosen, HR (reprint author), GI & Hepatol Div, B-158,Acad Off Bldg 1,12631 E 17th Ave,Room 7614,, Aurora, CO 80045 USA.
EM Hugo.Rosen@UCHSC.edu
FU U19 HCV Center [RO1 AI 066209]
FX This study was supported by a U19 HCV Center Grant to H. R. R. and grant
RO1 AI 066209 to D. R. G.
NR 25
TC 224
Z9 243
U1 0
U2 9
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD SEP 15
PY 2009
VL 83
IS 18
BP 9122
EP 9130
DI 10.1128/JVI.00639-09
PG 9
WC Virology
SC Virology
GA 485MI
UT WOS:000269127000010
PM 19587053
ER
PT J
AU Vesper, HW
Bhasin, S
Wang, C
Tai, SS
Dodge, LA
Singh, RJ
Nelson, J
Ohorodnik, S
Clarke, NJ
Salameh, WA
Parker, CR
Razdan, R
Monsell, EA
Myers, GL
AF Vesper, Hubert W.
Bhasin, Shalender
Wang, Christina
Tai, Susan S.
Dodge, Larry A.
Singh, Ravinder J.
Nelson, Judie
Ohorodnik, Susan
Clarke, Nigel J.
Salameh, Wael A.
Parker, C. Richard, Jr.
Razdan, Raj
Monsell, Elizabeth A.
Myers, Gary L.
TI Interlaboratory comparison study of serum total testosterone
measurements performed by mass spectrometry methods (vol 74, pg 498,
2009)
SO STEROIDS
LA English
DT Correction
C1 [Vesper, Hubert W.; Razdan, Raj; Monsell, Elizabeth A.; Myers, Gary L.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
[Bhasin, Shalender] Boston Univ, Sch Med, Boston, MA 02118 USA.
[Wang, Christina] Univ Calif Los Angeles, Sch Med, Harbor UCLA Med Ctr, Torrance, CA 90509 USA.
[Wang, Christina] Univ Calif Los Angeles, Sch Med, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA.
[Tai, Susan S.] NIST, Chem Sci & Technol Lab, Div Analyt Chem, Gaithersburg, MD 20899 USA.
[Dodge, Larry A.; Singh, Ravinder J.] Mayo Fdn, Rochester, MN 55905 USA.
[Nelson, Judie] Childrens & Womens Hlth Ctr BC, Newborn Screening Biochem Genet Labs, Vancouver, BC V6H 3V4, Canada.
[Ohorodnik, Susan] Taylor Technol Inc, Princeton, NJ 08540 USA.
[Clarke, Nigel J.; Salameh, Wael A.] QuestDiagnost Nichols Inst, San Juan Capistrano, CA 92675 USA.
[Parker, C. Richard, Jr.] Univ Alabama, Dept Obstet & Gynecol, Birmingham, AL 35294 USA.
RP Vesper, HW (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,NE F25, Atlanta, GA 30341 USA.
EM HVesper@cdc.gov
NR 1
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-128X
J9 STEROIDS
JI Steroids
PD SEP 15
PY 2009
VL 74
IS 9
BP 791
EP 791
DI 10.1016/j.steroids.2009.05.001
PG 1
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 472KH
UT WOS:000268129000014
ER
PT J
AU Spiropoulou, CF
Ranjan, P
Pearce, MB
Sealy, TK
Albarino, CG
Gangappa, S
Fujita, T
Rollin, PE
Nichol, ST
Ksiazek, TG
Sambhara, S
AF Spiropoulou, Christina F.
Ranjan, Priya
Pearce, Melissa B.
Sealy, Tara K.
Albarino, Cesar G.
Gangappa, Shivaprakash
Fujita, Takashi
Rollin, Pierre E.
Nichol, Stuart T.
Ksiazek, Thomas G.
Sambhara, Suryaprakash
TI RIG-I activation inhibits ebolavirus replication
SO VIROLOGY
LA English
DT Article
DE Ebolavirus; RIG-I
ID DOUBLE-STRANDED-RNA; VP35 PROTEIN; INTERFERON INDUCTION; ANTIVIRAL
RESPONSES; HEMORRHAGIC-FEVER; IMMUNE-RESPONSES; INNATE IMMUNITY;
VIRUSES; RECOGNITION; THERAPEUTICS
AB Hemorrhagic fever viruses are associated with rapidly progressing severe disease with high case fatality, making them of public health and biothreat importance. Effective antivirals are not available for most of the members of this diverse group of viruses. A broad spectrum strategy for antiviral development would be very advantageous. Perhaps the most challenging target would be the highly immunosuppressive filoviruses, ebolovirus and marburgvirus, associated with aerosol infectivity and case fatalities in the 80-90% range. Here we report that activation of evolutionarily conserved cytosolic viral nucleic acid sensor, RIG-I can cause severe inhibition of ebolavirus replication. These findings indicate that RIG-I-based therapies may provide an attractive approach for antivirals against Ebola hemorrhagic fever, and possibly other HF viruses. Published by Elsevier Inc.
C1 [Spiropoulou, Christina F.; Sealy, Tara K.; Albarino, Cesar G.; Rollin, Pierre E.; Nichol, Stuart T.; Ksiazek, Thomas G.] Ctr Dis Control & Prevent, Special Pathogens Branch, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA.
[Ranjan, Priya; Pearce, Melissa B.; Gangappa, Shivaprakash; Sambhara, Suryaprakash] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA.
[Fujita, Takashi] Kyoto Univ, Kyoto 6068501, Japan.
RP Spiropoulou, CF (reprint author), Ctr Dis Control & Prevent, Special Pathogens Branch, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA.
EM ccs8@cdc.gov
FU NVPO
FX The work was supported by a grant from NVPO awarded to SS.
NR 28
TC 24
Z9 26
U1 3
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0042-6822
J9 VIROLOGY
JI Virology
PD SEP 15
PY 2009
VL 392
IS 1
BP 11
EP 15
DI 10.1016/j.virol.2009.06.032
PG 5
WC Virology
SC Virology
GA 494BG
UT WOS:000269783500002
PM 19628240
ER
PT J
AU Burr, CK
Fry, RS
Weber, S
Armas-Kolostroubis, LN
Lampe, MA
AF Burr, Carolyn K.
Fry, Rebecca S.
Weber, Shannon
Armas-Kolostroubis, Laura N.
Lampe, Margaret A.
TI Integrating reproductive health into HIV care of women in the United
States: it is time
SO AIDS
LA English
DT Letter
C1 [Burr, Carolyn K.; Fry, Rebecca S.] Univ Med & Dent New Jersey, Sch Nursing, Francois Xavier Bagnoud Ctr, Newark, NJ 07101 USA.
[Weber, Shannon] Univ Calif San Francisco, Natl HIV AIDS Clinicians Consultat Ctr, San Francisco, CA 94143 USA.
[Armas-Kolostroubis, Laura N.] Parkland Hlth & Hosp Syst & Texas, Oklahoma AIDS Educ & Training Ctr, Dallas, TX USA.
[Lampe, Margaret A.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Epidemiol Branch, Atlanta, GA USA.
RP Fry, RS (reprint author), Univ Med & Dent New Jersey, Sch Nursing, Francois Xavier Bagnoud Ctr, 65 Bergen St,8th Floor, Newark, NJ 07101 USA.
EM fryre@umdnj.edu
NR 6
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U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0269-9370
J9 AIDS
JI Aids
PD SEP 10
PY 2009
VL 23
IS 14
BP 1928
EP 1930
DI 10.1097/QAD.0b013e328330f2ee
PG 3
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 495QJ
UT WOS:000269908800023
PM 19710563
ER
PT J
AU Fukagawa, C
Alvarez, F
Messenger, S
Schnurr, D
Gavali, S
Glaser, CA
Sun, B
Ocana, M
Waterman, S
Blanton, JD
Rupprecht, CE
AF Fukagawa, C.
Alvarez, F.
Messenger, S.
Schnurr, D.
Gavali, S.
Glaser, C. A.
Sun, B.
Ocana, M.
Waterman, S.
Blanton, J. D.
Rupprecht, C. E.
TI Imported Human Rabies-California, 2008 (Reprinted from MMWR, vol 58, pg
713-716, 2009)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Fukagawa, C.; Alvarez, F.] Santa Barbara Cty Publ Hlth Dept, Santa Barbara, CA USA.
[Blanton, J. D.; Rupprecht, C. E.] CDC, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA.
RP Fukagawa, C (reprint author), Santa Barbara Cty Publ Hlth Dept, Santa Barbara, CA USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD SEP 9
PY 2009
VL 302
IS 10
BP 1051
EP 1052
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 491XH
UT WOS:000269616200010
ER
PT J
AU Chace, DH
Lim, T
Hansen, CR
De Jesus, VR
Hannon, WH
AF Chace, Donald H.
Lim, Timothy
Hansen, Christina R.
De Jesus, Victor R.
Hannon, W. Harry
TI Improved MS/MS analysis of succinylacetone extracted from dried blood
spots when combined with amino acids and acylcarnitine butyl esters
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Tandem mass spectrometry; Succinylacetone; Acylcarnitines; Tyrosinemia
type 1; Dried blood spots; Newborn screening
ID TANDEM MASS-SPECTROMETRY; TYROSINEMIA TYPE-I; HEPATORENAL TYROSINEMIA;
HEREDITARY TYROSINEMIA; SPECIMENS; URINE; QUANTIFICATION; INFANTS
AB Background: The utilization of succinylacetone (SUAC) as the primary metabolic marker for tyrosinemia Type 1 is now well known. thus new methods have been developed to analyze SUAC as a first tier test in newborn screening. One approach is to prepare a SUAC hydrazine derivative from the dried blood spots (DBS) previously utilized in the extraction of acylcarnitine (AC) and amino acids (AA). The final derivatized products of SUAC, AA and AC are combined in a single tandem mass spectrometric (MS/MS) analysis. However, butyl esterification techniques may result in contamination of underivatized acylcarnitines by as much as 20%. We have developed a simple wash step to improve the combined analysis of SUAC, AA and AC in DBS by MS/MS.
Methods: AA and AC were extracted with methanol containing labeled internal standard from 3.2 mm punches taken from the DBS specimen. The previously extracted blood spot that remains after removal of the methanol extraction solvent was used in the preparation of SUAC with and without additional washing of the blood spot. The butyl ester eluates of AA and AC, and SUAC hydrazine derivatives were recombined and measured by MS/MS.
Results: Three additional methanol wash steps of the remaining DBS punches prior to SUAC derivatization reduced the presence of underivatized acylcarnitines, resulting in a 4-fold reduction of underivatized palmitoylcarnitine. Palmitoylcarnitine butyl ester is detected at m/z 456 while the underivatized species is detected at m/z 400, which is also the mass of dodecanoylcarnitine butyl ester. The linearity of the SUAC assay was unchanged by the additional wash steps. For butyl esterification methods, the preferred analytic procedure, the presence of AC can compromise the results of a newborn screen for the actual concentrations of acylcarnitines. It is essential to remove any underivatized acylcarnitines prior to SUAC analysis.
Conclusion: The additional methanol wash steps did not alter SUAC assay results but did remove underivatized acylcarnitines which could result in the incorrect quantification of acylcarnitines. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Chace, Donald H.; Hansen, Christina R.] Pediatrix Med Grp Inc, Pediatrix Analyt, Ctr Res & Educ, Sunrise, FL 33323 USA.
[Lim, Timothy; De Jesus, Victor R.; Hannon, W. Harry] Ctr Dis Control & Prevent, Newborn Screening Qual Assurance Program, Atlanta, GA 30341 USA.
RP Chace, DH (reprint author), Pediatrix Med Grp Inc, Pediatrix Analyt, Ctr Res & Educ, 1301 Concord Terrace, Sunrise, FL 33323 USA.
EM donald_chace@pediatrix.com
FU US Centers for Disease Control and Prevention's Newborn Screening
Quality Assurance Program (NSQAP)
FX This work was supported by the US Centers for Disease Control and
Prevention's Newborn Screening Quality Assurance Program (NSQAP). The
authors would like to acknowledge Ms. Barbara W. Adam and Drjoanne V.
Mei for helpful discussions regarding sample preparation. The findings
and conclusions in this report are those of the authors and do not
necessarily represent the official position of the Centers for Disease
Control and Prevention.
NR 15
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U1 1
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD SEP 3
PY 2009
VL 407
IS 1-2
BP 6
EP 9
DI 10.1016/j.cca.2009.06.017
PG 4
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 487ST
UT WOS:000269296800002
PM 19545553
ER
PT J
AU Hamer, DH
Singh, MP
Wylie, BJ
Yeboah-Antwi, K
Tuchman, J
Desai, M
Udhayakumar, V
Gupta, P
Brooks, MI
Shukla, MM
Awasthy, K
Sabin, L
MacLeod, WB
Dash, AP
Singh, N
AF Hamer, Davidson H.
Singh, Mrigendra P.
Wylie, Blair J.
Yeboah-Antwi, Kojo
Tuchman, Jordan
Desai, Meghna
Udhayakumar, Venkatachalam
Gupta, Priti
Brooks, Mohamad I.
Shukla, Manmohan M.
Awasthy, Kiran
Sabin, Lora
MacLeod, William B.
Dash, Aditya P.
Singh, Neeru
TI Burden of malaria in pregnancy in Jharkhand State, India
SO MALARIA JOURNAL
LA English
DT Article
ID RAPID DIAGNOSTIC-TEST; LOW-BIRTH-WEIGHT; EPIDEMIOLOGY; PREVENTION;
STRATEGIES; WOMEN
AB Background: Past studies in India included only symptomatic pregnant women and thus may have overestimated the proportion of women with malaria. Given the large population at risk, a cross sectional study was conducted in order to better define the burden of malaria in pregnancy in Jharkhand, a malaria-endemic state in central-east India.
Methods: Cross-sectional surveys at antenatal clinics and delivery units were performed over a 12-month period at two district hospitals in urban and semi-urban areas, and a rural mission hospital. Malaria was diagnosed by Giemsa-stained blood smear and/or rapid diagnostic test using peripheral or placental blood.
Results: 2,386 pregnant women were enrolled at the antenatal clinics and 718 at the delivery units. 1.8% (43/2382) of the antenatal clinic cohort had a positive diagnostic test for malaria (53.5% Plasmodium falciparum, 37.2% Plasmodium vivax, and 9.3% mixed infections). Peripheral parasitaemia was more common in pregnant women attending antenatal clinics in rural sites (adjusted relative risk [aRR] 4.31, 95% CI 1.84-10.11) and in those who were younger than 20 years (aRR 2.68, 95% CI 1.03-6.98). Among delivery unit participants, 1.7% (12/717) had peripheral parasitaemia and 2.4% (17/712) had placental parasitaemia. Women attending delivery units were more likely to be parasitaemic if they were in their first or second pregnancy (aRR 3.17, 95% CI 1.32-7.61), had fever in the last week (aRR 5.34, 95% CI 2.89-9.90), or had rural residence (aRR 3.10, 95% CI 1.66-5.79). Malaria control measures including indoor residual spraying (IRS) and untreated bed nets were common, whereas insecticide-treated bed nets (ITN) and malaria chemoprophylaxis were rarely used.
Conclusion: The prevalence of malaria among pregnant women was relatively low. However, given the large at-risk population in this malaria-endemic region of India, there is a need to enhance ITN availability and use for prevention of malaria in pregnancy, and to improve case management of symptomatic pregnant women.
C1 [Hamer, Davidson H.; Wylie, Blair J.; Yeboah-Antwi, Kojo; Brooks, Mohamad I.; Sabin, Lora; MacLeod, William B.] Boston Univ, Sch Publ Hlth, Ctr Global Hlth & Dev, Boston, MA 02118 USA.
[Hamer, Davidson H.; Yeboah-Antwi, Kojo; Sabin, Lora; MacLeod, William B.] Boston Univ, Sch Publ Hlth, Dept Int Hlth, Boston, MA 02118 USA.
[Hamer, Davidson H.] Boston Univ, Sch Publ Hlth, Dept Med, Infect Dis Sect, Boston, MA 02118 USA.
[Singh, Mrigendra P.; Gupta, Priti; Shukla, Manmohan M.; Awasthy, Kiran; Singh, Neeru] Natl Inst Malaria Res Field Stn, Jabalpur, Madhya Pradesh, India.
[Wylie, Blair J.] Massachusetts Gen Hosp, Dept Obstet & Gynecol, Div Maternal Fetal Med, Boston, MA 02114 USA.
[Tuchman, Jordan] Ctr Leadership & Management, Cambridge, MA 02139 USA.
[Desai, Meghna; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA.
[Dash, Aditya P.; Singh, Neeru] Natl Inst Malaria Res, Delhi, India.
[Singh, Neeru] Indian Council Med Res, Reg Med Res Ctr Tribals, Jabalpur, India.
RP Hamer, DH (reprint author), Boston Univ, Sch Publ Hlth, Ctr Global Hlth & Dev, Boston, MA 02118 USA.
EM dhamer@bu.edu; mrigendrapal@gmail.com; bwylie@partners.org;
kyantwi@bu.edu; jtuchman@msh.org; mud8@cdc.gov; vxu0@cdc.gov;
pritibiochem00@gmail.com; mib@bu.edu; mm_shukla57@yahoo.co.in;
kiranawasthi4@gmail.com; lsabin@bu.edu; wmacleod@bu.edu;
apdash2@rediffmail.com; oicmrc@yahoo.co.in
OI MacLeod, William/0000-0001-8003-8874; Hamer,
Davidson/0000-0002-4700-1495
FU United States Agency for International Development (USAID)/India
[GHS-A-00-03-00020-00]
FX We would like to thank Dr. MK Das, the study nurses, and Amrit Alok for
their efforts on behalf of the study. We also would like to acknowledge
the kind administrative and logistical support of the Chief Medical
Officers at each of the district hospitals, the Jharkhand State health
authorities, and the Indian Council of Medical Research.
NR 31
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U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD SEP 3
PY 2009
VL 8
AR 210
DI 10.1186/1475-2875-8-210
PG 11
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 495FQ
UT WOS:000269876400003
PM 19728882
ER
PT J
AU Rowe, AK
Kachur, SP
Yoon, SS
Lynch, M
Slutsker, L
Steketee, RW
AF Rowe, Alexander K.
Kachur, S. Patrick
Yoon, Steven S.
Lynch, Matthew
Slutsker, Laurence
Steketee, Richard W.
TI Caution is required when using health facility-based data to evaluate
the health impact of malaria control efforts in Africa
SO MALARIA JOURNAL
LA English
DT Article
AB The global health community is interested in the health impact of the billions of dollars invested to fight malaria in Africa. A recent publication used trends in malaria cases and deaths based on health facility records to evaluate the impact of malaria control efforts in Rwanda and Ethiopia. Although the authors demonstrate the use of facility-based data to estimate the impact of malaria control efforts, they also illustrate several pitfalls of such analyses that should be avoided, minimized, or actively acknowledged. A critique of this analysis is presented because many country programmes and donors are interested in evaluating programmatic impact with facility-based data. Key concerns related to: 1) clarifying the objective of the analysis; 2) data validity; 3) data representativeness; 4) the exploration of trends in factors that could influence malaria rates and thus confound the relationship between intervention scale-up and the observed changes in malaria outcomes; 5) the analytic approaches, including small numbers of patient outcomes, selective reporting of results, and choice of statistical and modeling methods; and 6) internal inconsistency on the strength and interpretation of the data. In conclusion, evaluations of malaria burden reduction using facility-based data could be very helpful, but those data should be collected, analysed, and interpreted with care, transparency, and a full recognition of their limitations.
C1 [Rowe, Alexander K.; Kachur, S. Patrick; Yoon, Steven S.; Slutsker, Laurence] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Natl Ctr Infect Dis,CDC, Atlanta, GA 30333 USA.
[Lynch, Matthew] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Commun Programs, Global Program Malaria, Baltimore, MD USA.
[Steketee, Richard W.] PATH, Ferney Voltaire, France.
RP Rowe, AK (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Natl Ctr Infect Dis,CDC, 4770 Buford Highway,Mail Stop F-12, Atlanta, GA 30333 USA.
EM axr9@cdc.gov; spk0@cdc.gov; say7@cdc.gov; mlynch@jhuccp.org;
lms5@cdc.gov; rsteketee@path.org
NR 6
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD SEP 3
PY 2009
VL 8
AR 209
DI 10.1186/1475-2875-8-209
PG 3
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 495FQ
UT WOS:000269876400002
PM 19728880
ER
PT J
AU Perea, EZ
Leon, RB
Salcedo, MP
Brogdon, WG
Devine, GJ
AF Zamora Perea, Elvira
Balta Leon, Rosario
Palomino Salcedo, Miriam
Brogdon, William G.
Devine, Gregor J.
TI Adaptation and evaluation of the bottle assay for monitoring insecticide
resistance in disease vector mosquitoes in the Peruvian Amazon
SO MALARIA JOURNAL
LA English
DT Article
ID AEDES-AEGYPTI DIPTERA; ANOPHELES-DARLINGI; MALARIA VECTORS; CULICIDAE;
REGION
AB Background: The purpose of this study was to establish whether the "bottle assay", a tool for monitoring insecticide resistance in mosquitoes, can complement and augment the capabilities of the established WHO assay, particularly in resource-poor, logistically challenging environments.
Methods: Laboratory reared Aedes aegypti and field collected Anopheles darlingi and Anopheles albimanus were used to assess the suitability of locally sourced solvents and formulated insecticides for use with the bottle assay. Using these adapted protocols, the ability of the bottle assay and the WHO assay to discriminate between deltamethrin-resistant Anopheles albimanus populations was compared. The diagnostic dose of deltamethrin that would identify resistance in currently susceptible populations of An. darlingi and Ae. aegypti was defined. The robustness of the bottle assay during a surveillance exercise in the Amazon was assessed.
Results: The bottle assay (using technical or formulated material) and the WHO assay were equally able to differentiate deltamethrin-resistant and susceptible An. albimanus populations. A diagnostic dose of 10 mu g a.i./bottle was identified as the most sensitive discriminating dose for characterizing resistance in An. darlingi and Ae. aegypti. Treated bottles, prepared using locally sourced solvents and insecticide formulations, can be stored for > 14 days and used three times. Bottles can be stored and transported under local conditions and field-assays can be completed in a single evening.
Conclusion: The flexible and portable nature of the bottle assay and the ready availability of its components make it a potentially robust and useful tool for monitoring insecticide resistance and efficacy in remote areas that require minimal cost tools.
C1 [Devine, Gregor J.] Rothamsted Res, Harpenden AL5 2JQ, Herts, England.
[Zamora Perea, Elvira] Lab Salud Publ, Iquitos, Peru.
[Balta Leon, Rosario; Palomino Salcedo, Miriam] Inst Nacl Salud, Lima, Peru.
[Brogdon, William G.] Ctr Dis Control, Atlanta, GA 30333 USA.
RP Devine, GJ (reprint author), Rothamsted Res, Harpenden AL5 2JQ, Herts, England.
EM elvirazamoraperea@hotmail.com; rbalta@ins.gob.pe; mpalomino@ins.gob.pe;
wgb1@cdc.gov; greg.devine@bbsrc.ac.uk
RI Devine, Gregor/H-1141-2014
FU Amazon Malaria Initiative (USAID) via an Inter Agency Agreement (IAA)
with CDC
FX This work was partially funded by the Amazon Malaria Initiative (USAID)
via an Inter Agency Agreement (IAA) with CDC. We thank Dr Raymond Beach
(CDC), Captain Gregory Martin and Commander John Sanders (US Navy
Medical Research Center Detachment, Peru) for their help in facilitating
this work. We thank Dr Moises Sihuincha, Dr Carlos Alvarez and Blgo.
Ernesto Curto (Directors of the Laboratorio de Salud Publica, Iquitos)
for their assistance. Dr Cesar Cabezas Sanchez, deputy director of the
Instituto Nacional de Salud (INS), and Dr Jorge Wong Armas, then
Director of Medical Investigations, Direccion de Salud (DISA) Loreto,
gave written permission for the surveillance exercise. We thank the
biologists, technicians and health promoters who took part in that
exercise: Iquitos; Andres Rojas, Wagner Orellana, Libertad; Roldan
Cardenas, Eulogio Shapiana, Mamerto Sandi, Isidoro Shahuano; Intuto;
Victor Macuyama, Cleyder Curico, Gabriel Tamano, Ullpayacu; Luis Pena,
Wilfredo Tuanamo, Elio Satalaya, Elio Musselini. We are grateful for the
support of Dra. Maria Gastanaga Ruiz, then Director General of the
Direccion General de Salud Ambiental (DIGESA), Blga. Elena Ogusku Asato,
Vector Control Coordinator (DIGESA) and Arturo Alvarado Aldana, then
head of the Centro de Investigacion y Capacitacion (CICE) Piura. We
thank those who assisted with the WHO/bottle assay comparison: Etty
Lopez (DISA San Martin), Yolanda Dominguez (DISA Tumbes), Karin Escobedo
(NMRCD), and Sonia Carrasco, Danilo Abanto, Teodoro Ticliahuanca and
Javier Herrera (CICE Piura). Rothamsted Research is an institute of the
Biotechnology and Biological Sciences Research Council of the United
Kingdom.
NR 31
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD SEP 3
PY 2009
VL 8
AR 208
DI 10.1186/1475-2875-8-208
PG 11
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 495FQ
UT WOS:000269876400001
ER
PT J
AU Jue, R
Schmalz, T
Carter, K
Nett, RJ
AF Jue, R.
Schmalz, T.
Carter, K.
Nett, R. J.
TI Outbreak of Cryptosporidiosis Associated With a Splash Park-Idaho, 2007
(Reprinted from MMWR, vol 58, pg 615-618, 2009)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Nett, R. J.] CDC, Atlanta, GA 30333 USA.
NR 12
TC 0
Z9 0
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD SEP 2
PY 2009
VL 302
IS 9
BP 938
EP 940
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 489TF
UT WOS:000269444900006
ER
PT J
AU Dannenberg, A
Bhatia, R
Wemham, A
AF Dannenberg, Andrew
Bhatia, Rajiv
Wemham, Aaron
TI Health Impact Assessment: A Step Toward Health in All Policies (vol 302,
pg 315, 2009)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Correction
C1 [Dannenberg, Andrew] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA.
[Bhatia, Rajiv] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Bhatia, Rajiv] San Francisco Dept Publ Hlth, San Francisco, CA USA.
[Wemham, Aaron] Alaska Nat Tribal Hlth Consortium, Anchorage, AK USA.
RP Dannenberg, A (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA.
NR 1
TC 0
Z9 0
U1 1
U2 3
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD SEP 2
PY 2009
VL 302
IS 9
BP 946
EP 946
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 489TF
UT WOS:000269444900018
ER
PT J
AU Belay, B
Dietz, WH
AF Belay, Brook
Dietz, William H.
TI Obesity Prevention and Control: From Clinical Tools to Public Health
Strategies
SO ACADEMIC PEDIATRICS
LA English
DT Editorial Material
C1 [Belay, Brook; Dietz, William H.] Ctr Dis Control & Prevent, Div Nutr & Phys Act, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
RP Belay, B (reprint author), Ctr Dis Control & Prevent, Div Nutr & Phys Act, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,MSK 24, Atlanta, GA 30341 USA.
EM bbelay@cdc.gov
NR 9
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-2859
J9 ACAD PEDIATR
JI Acad. Pediatr.
PD SEP-OCT
PY 2009
VL 9
IS 5
BP 291
EP 292
PG 2
WC Pediatrics
SC Pediatrics
GA 573KR
UT WOS:000275912700002
PM 19761977
ER
PT J
AU Walter, EB
Allred, N
Rowe-West, B
Chmielewski, K
Kretsinger, K
Dolor, RJ
AF Walter, Emmanuel B.
Allred, Norma
Rowe-West, Beth
Chmielewski, Kathlene
Kretsinger, Katrina
Dolor, Rowena J.
TI Cocooning Infants: Tdap Immunization for New Parents in the Pediatric
Office
SO ACADEMIC PEDIATRICS
LA English
DT Article
DE infants; pertussis; vaccine
ID YOUNG INFANTS; UNITED-STATES; PERTUSSIS
AB Objective. Vaccination with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) is recommended for adults who have close contact with infants aged <12 months to protect young infants from infection due to Bordetella pertussis. This study assessed the acceptance of Tdap vaccination among parents bringing their newborn to a pediatric office during the first month of life.
Methods. Parents of all newborns were consecutively approached for participation by a study coordinator who provided written information about the study and a Tdap vaccine information sheet. After obtaining informed consent, a study coordinator reviewed contraindications for Tdap vaccination. Tdap vaccine was given by a clinic nurse, but parents with a history of ever receiving Tdap vaccine or of receiving a tetanus and diphtheria vaccine (Td) within the previous 2 years were excluded.
Results. Two hundred parents were approached for study participation, of whom 40 (20%) were ineligible to receive Tdap vaccine primarily clue to receipt of Td vaccine within the previous 2 years (32/40). Of the 160 eligible to receive Tdap vaccine, 82 (51.2%) received a dose. Although nearly 60% of vaccinated parents received Tdap vaccine the first time they were approached, over 40% received Tdap vaccine at a subsequent office visit occurring during the baby's first month of life.
Conclusions. Offering Tdap vaccine in the pediatric office increases access to vaccination for both new fathers and mothers. When hospital-based, postpartum Tdap vaccination is not a routine practice, office-based vaccination of parents offers an option for protecting young infants.
C1 [Walter, Emmanuel B.; Chmielewski, Kathlene; Dolor, Rowena J.] Duke Univ, Med Ctr, Primary Care Res Consortium, Durham, NC USA.
[Allred, Norma; Kretsinger, Katrina] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Rowe-West, Beth] N Carolina Dept Hlth & Human Serv, Immunizat Branch, Raleigh, NC USA.
RP Walter, EB (reprint author), Duke Childrens Primary Care Clin, 4020 N Roxboro Rd, Durham, NC 27704 USA.
EM walte002@mc.duke.edu
FU Sanofi Pasteur; Centers tor Disease Control and Prevention
[5U01IP00074-02]
FX Dr Walter is a speaker for Sanofi Pasteur and has served as it principal
investigator for other clinical investigations sponsored by Sanofi
Pasteur.; This work was supported by the Centers tor Disease Control and
Prevention in a cooperative agreement with Duke University (grant
5U01IP00074-02, Dr Emmanuel Walter, principal investigator). Data were
presented in part at the 2008 Pediatric Academic Societies & Asian
Society for Pediatric Research Joint Meeting, May 3-6, 2008, Honolulu.
Hawaii.
NR 9
TC 36
Z9 36
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-2859
EI 1876-2867
J9 ACAD PEDIATR
JI Acad. Pediatr.
PD SEP-OCT
PY 2009
VL 9
IS 5
BP 344
EP 347
PG 4
WC Pediatrics
SC Pediatrics
GA 573KR
UT WOS:000275912700012
PM 19596219
ER
PT J
AU Paulozzi, LJ
Logan, JE
Hall, AJ
McKinstry, E
Kaplan, JA
Crosby, AE
AF Paulozzi, Leonard J.
Logan, Joseph E.
Hall, Aron J.
McKinstry, Edna
Kaplan, James A.
Crosby, Alexander E.
TI A comparison of drug overdose deaths involving methadone and other
opioid analgesics in West Virginia
SO ADDICTION
LA English
DT Article
DE Benzodiazepine; drug abuse; hydrocodone; medical examiner; methadone;
opioid; overdose; oxycodone
ID UNITED-STATES; ABUSE DEATHS; FATALITIES; COUNTY; SURVEILLANCE;
INVOLVEMENT; PATTERNS
AB Aims
To describe all people dying from unintentional overdoses of methadone or other opioid analgesics (OOA) in West Virginia in 2006.
Design
We analyzed medical examiner data supplemented by data from the state prescription drug monitoring program. We compared people whose deaths involved methadone with those whose deaths involved OOA.
Findings
The methadone group included 87 decedents, and the OOA group included 163 decedents. Most were male. Decedents in the methadone group were significantly younger than those in the OOA group: more than a quarter were 18-24 years of age. For both groups, approximately 50% had a history of pain, and 80% had a history of substance abuse. There was no intergroup difference in the prevalence of benzodiazepines at post-mortem. Methadone was significantly less likely to have ever been prescribed than OOA. Among those with prescriptions, the proportion prescribed within 30 days of death was significantly greater for methadone than for hydrocodone, but not for oxycodone. Ten (11.5%) of the methadone decedents were enrolled in an opiate treatment program (OTP) at the time of death.
Conclusions
The high prevalence of a substance abuse history and lack of prescriptions suggest that most of the deaths in both groups are related to substance abuse. There was no indication of a harmful effect from methadone's metabolic interaction with benzodiazepines, but provider or patient unfamiliarity with methadone may have been a risk factor. Prescribing methadone, especially to young males, requires extra care. Providers, OTPs and coroners/medical examiners should use state prescription drug monitoring programs to monitor the use of controlled substances by their patients.
C1 [Paulozzi, Leonard J.; Logan, Joseph E.; Crosby, Alexander E.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA.
[Logan, Joseph E.; Hall, Aron J.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30341 USA.
[McKinstry, Edna] Ctr Dis Control & Prevent, Epidemiol Elect Program, Atlanta, GA 30341 USA.
[Hall, Aron J.] W Virginia Dept Hlth & Human Resources, Div Surveillance & Dis Control, Charleston, WV USA.
[Kaplan, James A.] W Virginia Dept Hlth & Human Resources, Off Chief Med Examiner, Charleston, WV USA.
RP Paulozzi, LJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway NE,Mailstop F-62, Atlanta, GA 30341 USA.
EM lbp4@cdc.gov
FU Centers for Disease Control and Prevention
FX The findings and conclusions in this report are those of the authors and
do not necessarily represent the official position of the Centers for
Disease Control and Prevention.
NR 36
TC 57
Z9 58
U1 1
U2 6
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0965-2140
J9 ADDICTION
JI Addiction
PD SEP
PY 2009
VL 104
IS 9
BP 1541
EP 1548
DI 10.1111/j.1360-0443.2009.02650.x
PG 8
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA 479IQ
UT WOS:000268653300017
PM 19686524
ER
PT J
AU Basile, KC
Espelage, DL
Rivers, I
McMahon, PM
Simon, TR
AF Basile, Kathleen C.
Espelage, Dorothy L.
Rivers, Ian
McMahon, Pamela M.
Simon, Thomas R.
TI The theoretical and empirical links between bullying behavior and male
sexual violence perpetration
SO AGGRESSION AND VIOLENT BEHAVIOR
LA English
DT Review
DE Bullying; Sexual violence; Sexual harassment; Perpetration
ID MIDDLE SCHOOL STUDENTS; RISK-FACTORS; COLLEGE MEN; RELATIONAL
AGGRESSION; ASSAULT PERPETRATION; SOCIAL-ADJUSTMENT; NATIONAL SAMPLE;
PEER-GROUP; PSYCHOSOCIAL ADJUSTMENT; GENDER-DIFFERENCES
AB Bullying experiences and male sexual violence (SV) perpetration are major public health problems, and while extant literature suggests that they may share some developmental correlates, there is no established empirical link between being a perpetrator or victim of bullying and SV perpetration in the literature. Nonetheless, some SV prevention programs in the U.S. include bullying prevention components for elementary and middle-school aged children. Research is needed to test the hypothesized links between bullying experiences and SV perpetration to determine whether bullying prevention programs are likely to prevent SV perpetration. The purpose of this paper is to present results from a review of research on each of these topics and to discuss the potential shared and unique risk and protective factors within a social-ecological framework. The paper concludes with suggested directions for future research. Published by Elsevier Ltd.
C1 [Basile, Kathleen C.] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA 30333 USA.
[Espelage, Dorothy L.] Univ Illinois, Chicago, IL 60680 USA.
[Rivers, Ian] Brunel Univ, Uxbridge UB8 3PH, Middx, England.
RP Basile, KC (reprint author), Ctr Dis Control & Prevent, Div Violence Prevent, Mailstop F64,4770 Buford Highway, Atlanta, GA 30333 USA.
EM kbasile@cdc.gov
OI Rivers, Ian/0000-0001-6102-9075
NR 164
TC 22
Z9 23
U1 1
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-1789
EI 1873-6335
J9 AGGRESS VIOLENT BEH
JI Aggress. Violent Behav.
PD SEP-OCT
PY 2009
VL 14
IS 5
BP 336
EP 347
DI 10.1016/j.avb.2009.06.001
PG 12
WC Criminology & Penology; Psychology, Multidisciplinary
SC Criminology & Penology; Psychology
GA 498AA
UT WOS:000270105900008
ER
PT J
AU Gardner, LI
Marks, G
Craw, J
Metsch, L
Strathdee, S
Anderson-Mahoney, P
del Rio, C
AF Gardner, Lytt I.
Marks, Gary
Craw, Jason
Metsch, Lisa
Strathdee, Steffanie
Anderson-Mahoney, Pamela
del Rio, Carlos
CA Antiretroviral Treatment Access St
TI Demographic, Psychological, and Behavioral Modifiers of the
Antiretroviral Treatment Access Study (ARTAS) Intervention
SO AIDS PATIENT CARE AND STDS
LA English
DT Article
ID HEALTH-CARE UTILIZATION; INJECTION-DRUG USERS; HIV MEDICAL-CARE;
HETEROSEXUAL TRANSMISSION; INFECTED PERSONS; POSITIVE PERSONS; HOUSING
STATUS; VIRAL LOAD; SERVICES; INDIVIDUALS
AB The present study sought to identify demographic, structural, behavioral, and psychological subgroups for which the Antiretroviral Treatment Access Study (ARTAS) intervention had stronger or weaker effects in linking recently diagnosed HIV-positive persons to medical care. The study, carried out from 2001 to 2003, randomized 316 participants to receive either passive referral or a strengths-based linkage intervention to facilitate entry into HIV primary care. The outcome was attending at least one HIV primary care visit in each of two consecutive 6-month periods. Participants (71% male; 29% Hispanic; 57% black non-Hispanic), were recruited from sexually transmitted disease clinics, hospitals and community-based organizations in four U. S. cities. Thirteen effect modifier variables measured at baseline were examined. Subgroup differences were formally tested with interaction terms in unadjusted and adjusted log-linear regression models. Eighty-six percent (273/316) of participants had complete 12-month follow-up data. The intervention significantly improved linkage to care in 12 of 26 subgroups. In multivariate analysis of effect modification, the intervention was significantly (p < 0.05) stronger among Hispanics than other racial/ethnic groups combined, stronger among those with unstable than stable housing, and stronger among those who were not experiencing depressive symptoms compared to those who were. The ARTAS linkage intervention was successful in many but not all subgroups of persons recently diagnosed with HIV infection. For three variables, the intervention effect was significantly stronger in one subgroup compared to the counterpart subgroup. To increase its scope, the intervention may need to be tailored to the specific needs of groups that did not respond well to the intervention.
C1 [Gardner, Lytt I.] Ctr Dis Control & Prevent, Div HIV AIDS, Atlanta, GA 30333 USA.
[Craw, Jason] Northrop Grumman Inc, Atlanta, GA USA.
[Metsch, Lisa] Univ Miami, Miami, FL USA.
[Strathdee, Steffanie] Univ Calif San Diego, San Diego, CA 92103 USA.
[Anderson-Mahoney, Pamela] Hlth Res Assoc, Los Angeles, CA USA.
[del Rio, Carlos] Emory Univ, Sch Med, Atlanta, GA USA.
RP Gardner, LI (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS, 1600 Clifton Rd Mailstop E-45, Atlanta, GA 30333 USA.
EM lig0@cdc.gov
RI del Rio, Carlos/B-3763-2012
OI del Rio, Carlos/0000-0002-0153-3517
FU Centers for Disease Control and Prevention
FX The findings and conclusions in this report are those of the authors and
do not necessarily represent the views of the Centers for Disease
Control and Prevention.
NR 32
TC 17
Z9 17
U1 5
U2 8
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1087-2914
J9 AIDS PATIENT CARE ST
JI Aids Patient Care STDS
PD SEP
PY 2009
VL 23
IS 9
BP 735
EP 742
DI 10.1089/apc.2008.0262
PG 8
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 492OX
UT WOS:000269669300006
PM 19645619
ER
PT J
AU Reed, JB
Hanson, D
McNaghten, AD
Bertolli, J
Teshale, E
Gardner, L
Sullivan, P
AF Reed, J. Bailey
Hanson, Debra
McNaghten, A. D.
Bertolli, Jeanne
Teshale, Eyasu
Gardner, Lytt
Sullivan, Patrick
TI HIV Testing Factors Associated with Delayed Entry into HIV Medical Care
among HIV-Infected Persons from Eighteen States, United States,
2000-2004
SO AIDS PATIENT CARE AND STDS
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; RISK
SEXUAL-BEHAVIOR; HETEROSEXUAL TRANSMISSION; VIRAL LOAD; MEN; DIAGNOSIS;
HIV/AIDS; WOMEN; INCREASE
AB Despite the importance of timely entry into care after HIV diagnosis, the timing of care entry has not been described recently in a large, diverse population of persons with HIV. Dates of HIV diagnosis and entry into HIV care were obtained by interview of HIV-infected adults, most of whom had entered care for HIV, in 18 U. S. states from 2000 through 2004. Time to care entry was analyzed as a dichotomous variable; delayed care entry was defined as care entry greater than 3 months after HIV diagnosis. Multivariable logistic regression models were used to describe HIV testing-related factors associated with delayed care entry. Among 3942 respondents, 28% had delayed care entry. Diagnostic testing-related characteristics associated with delayed care entry included anonymous and first-time HIV testing. Providers of HIV testing should be aware that those who test positive anonymously and those whose first HIV test is positive may have increased risk for delayed HIV care entry. Developing programs that reinforce timely linkage to HIV care, targeted at those at increased risk for delaying care entry, should be a public health priority.
C1 [Reed, J. Bailey; Hanson, Debra; McNaghten, A. D.; Bertolli, Jeanne; Teshale, Eyasu; Gardner, Lytt; Sullivan, Patrick] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA.
RP Reed, JB (reprint author), Ctr Dis Control & Prevent, Div Global AIDS, 1600 Clifton Rd NE,MS E-04, Atlanta, GA 30333 USA.
EM eso7@cdc.gov
RI Sullivan, Patrick/A-9436-2009;
OI Sullivan, Patrick/0000-0002-7728-0587
NR 64
TC 31
Z9 32
U1 0
U2 4
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1087-2914
J9 AIDS PATIENT CARE ST
JI Aids Patient Care STDS
PD SEP
PY 2009
VL 23
IS 9
BP 765
EP 773
DI 10.1089/apc.2008.0213
PG 9
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 492OX
UT WOS:000269669300010
PM 19694550
ER
PT J
AU Beer, L
Fagan, JL
Valverde, E
Bertolli, J
AF Beer, Linda
Fagan, Jennifer L.
Valverde, Eduardo
Bertolli, Jeanne
CA Never Care Project
TI Health-Related Beliefs and Decisions about Accessing HIV Medical Care
among HIV-Infected Persons Who Are Not Receiving Care
SO AIDS PATIENT CARE AND STDS
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; ANTIRETROVIRAL TREATMENT ACCESS;
AFRICAN-AMERICAN WOMEN; POSITIVE PERSONS; PERCEIVED DISCRIMINATION;
COGNITIVE-DISSONANCE; CLINICAL CARE; UNMET NEED; STIGMA; INTERVENTION
AB In the United States, the publically supported national HIV medical care system is designed to provide HIV medical care to those who would otherwise not receive such care. Nevertheless, many HIV-infected persons are not receiving medical care. Limited information is available from HIV-infected persons not currently in care about the reasons they are not receiving care. From November 2006 to February 2007, we conducted five focus groups at community-based organizations and health departments in five U. S. cities to elicit qualitative information about barriers to entering HIV care. The 37 participants were mostly male (n = 29), over the age of 30 (n = 34), and all but one had not received HIV medical care in the previous 6 months. The focus group discussions revealed health belief-related barriers that have often been overlooked by studies of access to care. Three key themes emerged: avoidance and disbelief of HIV serostatus, conceptions of illness and appropriate health care, and negative experiences with, and distrust of, health care. Our findings point to the potentially important influence of these health-related beliefs on individual decisions about whether to access HIV medical care. We also discuss the implications of these beliefs for provider-patient communication, and suggest that providers frame their communications with patients such that they are attentive to the issues identified by our respondents, to better engage patients as partners in the treatment process.
C1 [Beer, Linda; Fagan, Jennifer L.; Valverde, Eduardo; Bertolli, Jeanne; Never Care Project] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
RP Beer, L (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd,NE,MS E-46, Atlanta, GA 30333 USA.
EM lbeer@cdc.gov
NR 60
TC 32
Z9 32
U1 4
U2 10
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1087-2914
J9 AIDS PATIENT CARE ST
JI Aids Patient Care STDS
PD SEP
PY 2009
VL 23
IS 9
BP 785
EP 792
DI 10.1089/apc.2009.0032
PG 8
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 492OX
UT WOS:000269669300012
PM 19645620
ER
PT J
AU Kersh, EN
Luo, W
Adams, DR
Srinivasan, P
Smith, JM
Promadej-Lanier, N
Ellenberger, D
Garcia-Lerma, JG
Butera, S
Otten, R
AF Kersh, Ellen N.
Luo, Wei
Adams, Debra R.
Srinivasan, Priya
Smith, James M.
Promadej-Lanier, Nattawan
Ellenberger, Dennis
Garcia-Lerma, J. Gerardo
Butera, Salvatore
Otten, Ron
TI Repeated Rectal SHIVSF162P3 Exposures Do Not Consistently Induce
Sustained T Cell Responses prior to Systemic Infection in the Repeat-Low
Dose Preclinical Macaque Model
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Article
ID SIMIAN IMMUNODEFICIENCY VIRUS; RHESUS MACAQUES; INTRAVAGINAL
INOCULATION; PERSISTENT VIREMIA; TRANSIENT VIREMIA; IMMUNE-RESPONSES;
HIV EPITOPES; NO EVIDENCE; MUCOSAL; TRANSMISSION
AB The macaque model of repeated SHIV exposures is increasingly used as a preclinical tool to evaluate biomedical HIV intervention strategies. It is unclear whether multiple virus exposures induce immune responses in macaques, as documented in uninfected individuals repeatedly exposed to HIV. We here address whether repeated, rectal SHIVSF162P3 exposures lead to systemic T cell activation in 12 rhesus macaques, and whether this is associated with increased infection resistance. Eight macaques became systemically infected after 2-7 exposures, three macaques were less susceptible (infection after 10-12 exposures), and one macaque remained uninfected after 14 exposures. PBMCs were retrospectively monitored for increases in T cell activation by analyzing the proportion of CD8(+) T cells, recently activated or proliferated T cells (markers CD38, Ki67), a marker for cytotoxicity (granzyme B), or T cell-produced plasma cytokines (IFN-gamma, RANTES, IL-2). Repeated virus exposures did not induce sustained, potent, or diverse T cell responses prior to systemic infection. Some changes occurred in the analyzed parameters during repeated virus exposures, but similar T cell activities were also observed in five SHIV-unexposed control macaques. Thus, we found no evidence that delayed infection or resistance to infection was associated with systemic, long-lasting, protective T cell responses to repeated rectal virus exposures. Our results provide further insights into the repeat exposure macaque model. We find that this model can be used for testing biomedical prevention strategies without concern of eliciting a systemic vaccination effect.
C1 [Kersh, Ellen N.; Luo, Wei; Adams, Debra R.; Srinivasan, Priya; Smith, James M.; Promadej-Lanier, Nattawan; Ellenberger, Dennis; Garcia-Lerma, J. Gerardo; Butera, Salvatore; Otten, Ron] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA.
RP Kersh, EN (reprint author), 1600 Clifton Rd,Mailstop A25, Atlanta, GA 30333 USA.
EM ekersh@cdc.gov
NR 36
TC 12
Z9 13
U1 0
U2 0
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD SEP
PY 2009
VL 25
IS 9
BP 905
EP 917
DI 10.1089/aid.2008.0287
PG 13
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 494ET
UT WOS:000269793700009
PM 19689194
ER
PT J
AU Looker, AC
Lacher, DA
Pfeiffer, CM
Schleicher, RL
Picciano, MF
Yetley, EA
AF Looker, Anne C.
Lacher, David A.
Pfeiffer, Christine M.
Schleicher, Rosemary L.
Picciano, Mary Frances
Yetley, Elizabeth A.
TI Data advisory with regard to NHANES serum 25-hydroxyvitamin D data
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Letter
C1 [Looker, Anne C.; Lacher, David A.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
[Pfeiffer, Christine M.; Schleicher, Rosemary L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Picciano, Mary Frances; Yetley, Elizabeth A.] NIH, Off Dietary Supplements, Bethesda, MD 20892 USA.
RP Looker, AC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
EM alooker@cdc.gov
NR 2
TC 13
Z9 13
U1 0
U2 2
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD SEP 1
PY 2009
VL 90
IS 3
BP 695
EP 695
DI 10.3945/ajcn.2009.28175
PG 1
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 487FW
UT WOS:000269257300033
PM 19571227
ER
PT J
AU Schmotzer, CL
Delille, C
Workowski, KA
Papp, JR
Hill, CE
Caliendo, AM
AF Schmotzer, Christine L.
Delille, Cecile
Workowski, Kimberly A.
Papp, John R.
Hill, Charles E.
Caliendo, Angela M.
TI Detection of Chlamydia trachomatis Lymphogranuloma Venereum in Men With
Proctitis
SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY
LA English
DT Meeting Abstract
CT 44th Annual Meeting of the
Academy-of-Clinical-Laboratory-Physicians-and-Scientists
CY JUN 04-06, 2009
CL Redondo Beach, CA
SP Acad Clin Lab Phys & Sci
C1 [Schmotzer, Christine L.; Hill, Charles E.; Caliendo, Angela M.] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA 30322 USA.
[Schmotzer, Christine L.; Hill, Charles E.; Caliendo, Angela M.] Emory Univ, Dept Med, Atlanta, GA 30322 USA.
[Delille, Cecile; Workowski, Kimberly A.; Caliendo, Angela M.] Emory Univ, Div Infect Dis, Atlanta, GA 30322 USA.
[Papp, John R.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER SOC CLINICAL PATHOLOGY
PI CHICAGO
PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA
SN 0002-9173
J9 AM J CLIN PATHOL
JI Am. J. Clin. Pathol.
PD SEP
PY 2009
VL 132
IS 3
MA 38
BP 458
EP 459
PG 2
WC Pathology
SC Pathology
GA 485XC
UT WOS:000269157600044
ER
PT J
AU Fleury, J
Keller, C
Perez, A
Lee, SM
AF Fleury, Julie
Keller, Colleen
Perez, Adriana
Lee, Sarah M.
TI The Role of Lay Health Advisors in Cardiovascular Risk Reduction: A
Review
SO AMERICAN JOURNAL OF COMMUNITY PSYCHOLOGY
LA English
DT Review
DE Lay health advisors; Cardiovascular risk reduction; Community-based
interventions
ID AFRICAN-AMERICAN WOMEN; SMOKING-CESSATION INTERVENTIONS; WEIGHT-LOSS
PROGRAM; PHYSICAL-ACTIVITY; LATINO COMMUNITY; WORKERS; EDUCATION;
DISEASE; CANCER; PROMOTION
AB Interventions are needed to reduce the negative impact of cardiovascular disease. The combination of health risks for disease, disability, and mortality, particularly among underserved populations, might be best addressed with programs designed to enhance awareness and development of resources within a context of community support. The objectives of this review were to: (1) provide a comprehensive review and evaluation of the roles, evaluation, and effectiveness of LHA in community-based programs with an emphasis on cardiovascular risk reduction; and (2) provide recommendations for future research involving LHA in such programs. Computer and manual searches were conducted of articles in the English-language literature from 1980 to 2007. Twenty articles were evaluated, which emphasized the role of the LHA in cardiovascular risk reduction. A review of research literature provides a starting point for determining salient approaches for intervention and evaluation, issues related to program implementation and sustainability, and strengths and limitations of existing approaches.
C1 [Fleury, Julie; Keller, Colleen; Perez, Adriana] Arizona State Univ, Coll Nursing & Healthcare Innovat, Phoenix, AZ 85004 USA.
[Lee, Sarah M.] Ctr Dis Control & Prevent, Div Adolescent, Atlanta, GA USA.
[Lee, Sarah M.] Ctr Dis Control & Prevent, Sch Hlth, Atlanta, GA USA.
RP Fleury, J (reprint author), Arizona State Univ, Coll Nursing & Healthcare Innovat, 500 N 3rd St,MC 3020, Phoenix, AZ 85004 USA.
EM julie.fleury@asu.edu
NR 51
TC 26
Z9 26
U1 2
U2 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0091-0562
J9 AM J COMMUN PSYCHOL
JI Am. J. Community Psychol.
PD SEP
PY 2009
VL 44
IS 1-2
BP 28
EP 42
DI 10.1007/s10464-009-9253-9
PG 15
WC Public, Environmental & Occupational Health; Psychology,
Multidisciplinary; Social Work
SC Public, Environmental & Occupational Health; Psychology; Social Work
GA 474OC
UT WOS:000268292800003
PM 19533327
ER
PT J
AU Arriola, KRJ
Usdan, S
Mays, D
Weitzel, JA
Cremeens, J
Martin, RJ
Borba, C
Bernhardt, JM
AF Arriola, Kimberly R. Jacob
Usdan, Stuart
Mays, Darren
Weitzel, Jessica Aungst
Cremeens, Jennifer
Martin, Ryan J.
Borba, Christina
Bernhardt, Jay M.
TI Reliability and Validity of the Alcohol Consequences Expectations Scale
SO AMERICAN JOURNAL OF HEALTH BEHAVIOR
LA English
DT Article
DE alcohol assessment; alcohol expectations; reliability; validity; college
students
ID BINGE-DRINKING; COLLEGE-STUDENTS; SELF-REPORTS; EXPECTANCY
QUESTIONNAIRE; NATIONAL-SURVEY; CONSUMPTION; TELEPHONE; PATTERNS;
BEHAVIOR; HEALTH
AB Objectives: To examine the reliability and validity of a new measure of alcohol outcome expectations for college students, the Alcohol Consequences Expectations Scale (ACES). Methods: College students (N=169) completed the ACES and several other measures. Results: Results support the existence of 5 internally consistent subscales. Additionally, the ACES is associated with conceptually similar measures and self-reported drinking behavior. Conclusions: This study supports the reliability of the ACES and its subscales and provides preliminary evidence of construct and criterion-related validity. Pending further investigation, this scale may be used to inform the development of alcohol abuse prevention programs on college campuses.
C1 [Arriola, Kimberly R. Jacob; Mays, Darren; Borba, Christina] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Usdan, Stuart] Univ Alabama, Dept Hlth Sci, Tuscaloosa, AL USA.
[Weitzel, Jessica Aungst] Ciurczak & Co Inc, Buffalo, NY USA.
[Cremeens, Jennifer] E Carolina Univ, Greenville, NC USA.
[Bernhardt, Jay M.] Ctr Dis Control & Prevent, Natl Ctr Hlth Mkt, Atlanta, GA USA.
RP Arriola, KRJ (reprint author), Emory Univ, Rollins Sch Publ Hlth, 1518 Clifton Rd NE,Room 510, Atlanta, GA 30322 USA.
EM kjacoba@sph.emory.edu
OI Bernhardt, Jay/0000-0002-2045-4005
FU NIAAA NIH HHS [5R21AA013969-03]
NR 50
TC 5
Z9 5
U1 2
U2 6
PU PNG PUBLICATIONS
PI OAK RIDGE
PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA
SN 1945-7359
J9 AM J HEALTH BEHAV
JI Am. J. Health Behav.
PD SEP-OCT
PY 2009
VL 33
IS 5
BP 504
EP 512
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 496TP
UT WOS:000270001800003
PM 19296740
ER
PT J
AU Albalak, R
AF Albalak, Rachel
TI From Biological Anthropology to Applied Public Health: Epidemiological
Approaches to the Study of Infectious Disease
SO AMERICAN JOURNAL OF HUMAN BIOLOGY
LA English
DT Article; Proceedings Paper
CT Symposium on Integrative Approaches to the Study of Human Adaptation and
Population Health
CY APR 11, 2008
CL Columbus, OH
ID COMMUNITIES
AB This article describes two large, multisite infectious disease programs: the Tuberculosis Epidemiologic Studies Consortium (TBESC) and the Emerging Infections Programs (EIPs). The links between biological anthropology and applied public health are highlighted using these programs as examples. Funded by the Centers for Disease Control and Prevention (CDC), the TBESC and EIPs conduct applied public health research to strengthen infectious disease prevention and control efforts in the United States. They involve collaborations among CDC, public health departments, and academic and clinical institutions. Their unique role in national infectious disease work, including their links to anthropology, shared elements, key differences, strengths and challenges, is discussed. Am. J. Hum. Biol. 21:687-693, 2009. (dagger)Published 2009 Wiley-Liss, Inc.
C1 Ctr Dis Control & Prevent, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30329 USA.
RP Albalak, R (reprint author), Ctr Dis Control & Prevent, Natl Ctr Preparedness Detect & Control Infect Dis, 1600 Clifton Rd NE, Atlanta, GA 30329 USA.
EM rka3@cdc.gov
NR 19
TC 1
Z9 1
U1 2
U2 6
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1042-0533
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD SEP-OCT
PY 2009
VL 21
IS 5
BP 687
EP 693
DI 10.1002/ajhb.20942
PG 7
WC Anthropology; Biology
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA 486BH
UT WOS:000269169900013
PM 19533620
ER
PT J
AU Park, RM
Bushnell, PT
Bailer, AJ
Collins, JW
Stayner, LT
AF Park, Robert M.
Bushnell, P. Timothy
Bailer, A. John
Collins, James W.
Stayner, Leslie T.
TI Impact of Publicly Sponsored Interventions on Musculoskeletal Injury
Claims in Nursing Homes
SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
LA English
DT Article
DE certified nursing aide; consultation; ergonomics; injury costs; resident
acuity; staffing ratio; training courses
ID BACK INJURIES
AB Background The rate of lost-time sprains and strains in private nursing homes is over three times the national average, and for back injuries, almost four times the national average. The Ohio Bureau of Workers' Compensation (BWC) has sponsored interventions that were preferentially promoted to nursing homes in 2000-2001, including training, consultation, and grants up to $40,000 for equipment purchases.
Methods This study evaluated the impact of BWC interventions on back injury claim rates using BWC data on claims, interventions, and employer payroll for all Ohio nursing homes during 1995-2004 using Poisson regression. A subset of nursing homes was analyzed with more detailed data that allowed estimation of the impact of staffing levels and resident acuity on claim rates. Costs of interventions were compared to the associated savings in claim costs.
Results A $500 equipment purchase per nursing home worker was associated with a 21% reduction in back injury rate. Assuming an equipment lift of 10 years, this translates to an estimated $768 reduction in claim costs per worker a present value of $495 with a 5% discount rate applied. Results for training courses were equivocal. Only those receiving below-median hours had a significant 19% reduction in claim rates. Injury rates did not generally decline with consultation independent of equipment purchases, although possible confounding, misclassification, and bias due to non-random management participation clouds interpretation. In. nursing homes with available data, resident acuity was modestly associated with back injury risk, and the injury rate increased with resident-to-staff ratio (acting through three terms: RR = 1.50 for each additional resident per staff member;for the ratio alone, RR = 1.32, 95% CI = 1.18-1.48). In these NHs, an expenditure of $908 per resident care worker (equivalent to $500 per employee in the other model) was also associated with a 21% reduction in injury rate. However with a resident-to-staff ratio greater than 2.0, the same expenditure was associated with a $1,643 reduction in back claim costs over 10 years per employee, a present value of $1,062 with 5% discount rate.
Conclusions Expenditures for ergonomic equipment in nursing homes by the Ohio BWC were associated with fewer worker injuries and reductions in claim costs that were similar in magnitude to expenditures. Un-estimated benefits and costs also need to be considered in assessing full health and financial impacts. Am. J. Ind. Med. 52:683-697, 2009. (C) 2009 Wiley-Liss, Inc.
C1 [Park, Robert M.] NIOSH, Educ & Informat Div, Risk Evaluat Branch, Cincinnati, OH 45226 USA.
[Bushnell, P. Timothy] NIOSH, Div Surveillance Hazard Evaluat & Field Studi, Cincinnati, OH 45226 USA.
[Bailer, A. John] Miami Univ, Scripps Gerontol Ctr, Dept Stat, Oxford, OH 45056 USA.
[Collins, James W.] NIOSH, Div Safety Res, Morgantown, WV 26505 USA.
[Stayner, Leslie T.] Univ Illinois, Sch Publ Hlth, Dept Epidemiol, Chicago, IL USA.
RP Park, RM (reprint author), NIOSH, Educ & Informat Div, Risk Evaluat Branch, 4676 Columbia Pkwy,C-15, Cincinnati, OH 45226 USA.
EM rhp9@cdc.gov
NR 30
TC 18
Z9 18
U1 0
U2 2
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0271-3586
J9 AM J IND MED
JI Am. J. Ind. Med.
PD SEP
PY 2009
VL 52
IS 9
BP 683
EP 697
DI 10.1002/ajim.20731
PG 15
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 490CO
UT WOS:000269475100003
PM 19670260
ER
PT J
AU Chen, GX
AF Chen, Guang X.
TI Nonfatal Work-Related Motor Vehicle Injuries Treated in Emergency
Departments in the United States, 1998-2002
SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
LA English
DT Article
DE motor vehicle injury; motor vehicle crash; occupational injury;
emergency department; surveillance
ID OCCUPATIONAL INJURIES; HOSPITAL EMERGENCY; TRAFFIC ACCIDENTS; OLDER
WORKERS; NEW-ZEALAND; EXPOSURES; INDUSTRY; SAMPLE; RISK
AB Background Current data on nonfatal work-related motor vehicle injuries are limited and fragmented, often excluding government workers, self-employed workers, and workers on small farms. This study seeks to bridge the present data gap by providing a national profile of nonfatal work-related motor vehicle injuries across all industries and occupations.
Methods Study subjects were people who suffered nonfatal work-related motor vehicle injuries and were treated in a hospital emergency department in the United States. Subjects were identified from a stratified probability sample of emergency departments. National estimates and rates were computed.
Results From 1998 to 2002, the average annual rate of nonfatal work-related motor vehicle injuries was 7 injuries per 10,000 full-time equivalents. The rate was three times higher in men than in women. The rates were higher in workers 15-19 years of age and in workers 70 years or older Justice, public order and safety workers had the largest number of injuries, and taxicab service employees had the highest injury rate of all industries. Truck drivers had the largest number of injuries, and police and detectives, public service employees had the highest injury rate of all occupations.
Conclusion Future efforts need to develop and enhance the use of surveillance information at the federal and state level for work-related nonfatal motor vehicle injuries. Prevention efforts need to address occupational motor vehicle safety for both commercial truck/bus drivers and workers who are not commercial drivers but who drive light motor vehicles on the job. Am. J. Ind. Med. 52:698-706, 2009. (C) 2009 Wiley-Liss, Inc.
C1 NIOSH, Anal & Field Operat Branch, Div Safety Res, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
RP Chen, GX (reprint author), NIOSH, Anal & Field Operat Branch, Div Safety Res, Ctr Dis Control & Prevent, 1095 Willowdale Rd,MS 1811, Morgantown, WV 26505 USA.
EM gchen@cdc.gov
FU NIOSH
FX Tim Pizatella for his initiation of the project; Harlan Amandus for his
technical contribution; Larry Jackson, Suzanne M. Marsh, and Susan Derk
for their assistance on the NEISS-Work data; and CDC editors Nicholas
Lawryk and John Lechliter for editorial assistance. The findings and
conclusions in this report are those of the author and do not
necessarily represent the views of the National Institute for
Occupational Safety and Health. The author gratefully acknowledges the
following NIOSH employees for their assistance with this manuscript:
NR 38
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U1 1
U2 3
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0271-3586
J9 AM J IND MED
JI Am. J. Ind. Med.
PD SEP
PY 2009
VL 52
IS 9
BP 698
EP 706
DI 10.1002/ajim.20726
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 490CO
UT WOS:000269475100004
PM 19609982
ER
PT J
AU Clark, SJ
Cowan, AE
Wortley, PM
AF Clark, Sarah J.
Cowan, Anne E.
Wortley, Pascale M.
TI Influenza vaccination attitudes and practices among US registered nurses
SO AMERICAN JOURNAL OF INFECTION CONTROL
LA English
DT Article
DE Influenza; vaccination; nurses; survey
ID HEALTH-CARE WORKERS; UNITED-STATES; PHYSICIANS; KNOWLEDGE; BELIEFS;
RECEIPT
AB Background: The influenza vaccination rate among US health care personnel (HCP) remains low and may vary by Occupational categories. The objective of this study was to explore knowledge, attitudes, and beliefs associated with influenza vaccination in a broad population of registered nurses.
Methods: The study used a cross-sectional mail survey, administered January-March 2006, of 2000 registered nurses ill 4 US states.
Results: Of the 2000 surveys sent, 1310 (72%) were returned, and 1017 (67%.) were eligible for analysis. The majority of respondents (59%) reported receiving influenza vaccine during the 2005-2006 influenza season. The most common reason for being vaccinated was protecting oneself from illness (95%), and the most common reason for not being vaccinated was concern about adverse reactions (3996). Respondents who reported their patient Population as high risk related to influenza were more likely to be vaccinated and to agree with statements regarding influenza disease and influenza vaccination of HCP.
Conclusion: Concerns about adverse reactions and vaccine effectiveness continue to be barriers to influenza vaccination among registered nurses. Those most knowledgeable about influenza vaccination of HCP have higher vaccination rates. Future efforts to improve vaccination rates should include data on vaccine effectiveness and adverse effects. as well as descriptions of high-risk populations.
C1 [Clark, Sarah J.; Cowan, Anne E.] Univ Michigan, CHEAR Unit, Ann Arbor, MI 48109 USA.
[Wortley, Pascale M.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
RP Clark, SJ (reprint author), Univ Michigan, CHEAR Unit, 300 N Ingalls Room 6E06, Ann Arbor, MI 48109 USA.
EM saclark@med.umich.edu
FU Centers for Disease Control and Prevention
FX Supported by the Centers for Disease Control and Prevention.
NR 17
TC 34
Z9 35
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-6553
J9 AM J INFECT CONTROL
JI Am. J. Infect. Control
PD SEP
PY 2009
VL 37
IS 7
BP 551
EP 556
DI 10.1016/j.ajic.2009.02.012
PG 6
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 494CF
UT WOS:000269786300005
PM 19556035
ER
PT J
AU Schillie, SF
Shehab, N
Thomas, KE
Budnitz, DS
AF Schillie, Sarah F.
Shehab, Nadine
Thomas, Karen E.
Budnitz, Daniel S.
TI Medication Overdoses Leading to Emergency Department Visits Among
Children
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID ADVERSE DRUG EVENTS; NATIONAL SURVEILLANCE; AMERICAN-ASSOCIATION;
SYSTEM; ACETAMINOPHEN; PREVENTION; REDUCTION; ERRORS
AB Background: The high prevalence of medication use increases the potential for medication overdoses, especially among children.
Purpose: This paper describes the burden Of unintentional pediatric medication overdoses in order to target new prevention efforts.
Methods: Data were analyzed in 2007 and 2008 from the National Electronic Injury Surveillance System, collected January 1, 2004, through December 11, 2005, to estimate the number of emergency department visits resulting from unintentional medication overdoses among children aged <= 18 years in the U.S. These data were analyzed by patient demographics, overdose cause, and implicated products, and compared to visits for nonpharmaceutical consumer product poisonings.
Results: Based on 3034 cases, an estimated 71,224 emergency department visits for medication overdoses were made annually by children aged <= 18 years, representing 68.9% of emergency department visits for unintentional pediatric poisonings. The rate of unintentional poisonings from medications was twice the rate of those from nonpharmaceutical consumer products (9.2 visits per 10,000 individuals per year [95% CI=7.3, 11.0] vs 4.2 per 10,000 individuals per year [95% CI=3.3, 5.0]). Four fifths (82.2%) of visits for medication overdoses were from unsupervised ingestions (children accessing medications on their own); medication errors and misuse resulted in 14.3% of visits. Most visits (81.3%) involved children aged <= 5 years, and commonly available over-the-counter medications were implicated in one third (33.9%) of visits.
Conclusions: Medication overdoses among children, notably unsupervised ingestions, represent a substantial burden in terms of emergency department visits and hospitalizations. New efforts to prevent pediatric medication overdoses are needed. (Am,J Prev Med 2009;37(3):181-187) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine
C1 [Schillie, Sarah F.; Shehab, Nadine; Budnitz, Daniel S.] CDC, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
[Thomas, Karen E.] CDC, Div Injury Response, Atlanta, GA 30333 USA.
[Schillie, Sarah F.] CDC, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA.
RP Budnitz, DS (reprint author), CDC, Div Healthcare Qual Promot, 1600 Clifton Rd NE,MS A-24, Atlanta, GA 30333 USA.
EM dbudnitz@cdc.gov
FU CDC funding; Oak Ridge Institute for Science and Education; U.S.
Department of Energy
FX This work was implemented using CDC funding and was supported in part by
an appointment (Dr. Shehab) to the CDC Research Participation Program
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and the CDC. None of the funding sources had a role in the Study design;
in the collection, analysis, and interpretation of data; in the writing
of the report; or in the decision to Submit the article for publication.
The findings and conclusions in this report are those of the authors and
do not necessarily represent the views of the funding agencies.
NR 33
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Z9 57
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD SEP
PY 2009
VL 37
IS 3
BP 181
EP 187
DI 10.1016/j.amepre.2009.05.018
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 487RA
UT WOS:000269291300002
PM 19666156
ER
PT J
AU Subramanian, S
Ekwueme, DU
Gardner, JG
Trogdon, J
AF Subramanian, Sujha
Ekwueme, Donatus U.
Gardner, James G.
Trogdon, Justin
TI Developing and Testing a Cost-Assessment Tool for Cancer Screening
Programs
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID DRUG-ABUSE TREATMENT; CERVICAL-CANCER; COLORECTAL-CANCER; NATIONAL
BREAST; ECONOMIC EVALUATIONS; ADDICTION TREATMENT; HEALTH; SERVICES;
DATCAP; STATES
AB Background: Cancer screening programs require substantial resources, and economic assessments have become increasingly important in identifying the most cost-effective means of conducting these programs. Such economic assessments require detailed program cost data, but there is no standardized instrument for obtaining these data.
Purpose: This study was designed to develop a standardized instrument to collect cost data from cancer screening programs.
Methods: A cost-assessment tool (CAT) was developed to collect annual cost data based on the findings from case studies at four sites funded by the National Breast and Cervical Cancer Early Detection Program (NBCCEDP). The data elements collected in the CAT were specifically tailored to collect cost and resource-use information from cancer screening programs. The tool was pilot-tested at nine NBCCEDP sites, and activity-based costs were generated by assigning all cost and resource-use data to specific program activities. Data were collected from November 2004 to February 2005, and the analysis was performed from March to July 2005.
Results: Overall, a majority of the sites (eight of nine) met the acceptable threshold of <5% of total 9 cost remaining unallocated. On average, the largest cost components of the nine programs were screening and diagnostic services (44.4%); recruitment (11.4%); database management (10.9%); and patient support/case management (9.3%).
Conclusions: Findings from the CAT pilot-testing showed that NBCCEDP cancer screening programs were able to report detailed activity-based cost data. The comparability of these cost data across programs should facilitate pooled analyses that, in turn, may lead to a better understanding of the impact and cost effectiveness of the screening program. (Am J Prev Med 2009;37(3):242-247) (C) 2009 American Journal of Preventive Medicine
C1 [Subramanian, Sujha; Trogdon, Justin] RTI Int, Waltham, MA 02451 USA.
[Ekwueme, Donatus U.; Gardner, James G.] CDC, Div Canc Prevent & Control, Atlanta, GA 30333 USA.
RP Subramanian, S (reprint author), RTI Int, 1440 Main St,Suite 310, Waltham, MA 02451 USA.
EM ssubramanian@rti.org
NR 30
TC 13
Z9 13
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD SEP
PY 2009
VL 37
IS 3
BP 242
EP 247
DI 10.1016/j.amepre.2009.06.002
PG 6
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 487RA
UT WOS:000269291300012
PM 19666160
ER
PT J
AU Beitsch, LM
Corso, LC
AF Beitsch, Leslie M.
Corso, Liza C.
TI Accountability: The East lane on the Highway to Change
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Editorial Material
C1 [Beitsch, Leslie M.; Corso, Liza C.] Ctr Dis Control & Prevent, Off Chief Publ Hlth Practice, Atlanta, GA 30333 USA.
RP Beitsch, LM (reprint author), Ctr Dis Control & Prevent, Off Chief Publ Hlth Practice, Atlanta, GA 30333 USA.
NR 0
TC 4
Z9 4
U1 0
U2 0
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD SEP
PY 2009
VL 99
IS 9
BP 1545
EP 1545
DI 10.2105/AJPH.2009.172957
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 488FL
UT WOS:000269334500007
PM 19608935
ER
PT J
AU Gulati, RK
Kwan-Gett, T
Hampson, NB
Baer, A
Shusterman, D
Shandro, JR
Duchin, JS
AF Gulati, Reena K.
Kwan-Gett, Tao
Hampson, Neil B.
Baer, Atar
Shusterman, Dennis
Shandro, Jamie R.
Duchin, Jeffrey S.
TI Carbon Monoxide Epidemic Among Immigrant Populations: King County,
Washington, 2006
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID ICE STORM
AB Objectives. We investigated an outbreak of carbon monoxide (CO) poisoning after a power outage to determine its extent, identify risk factors, and develop prevention measures.
Methods. We reviewed medical records and medical examiner reports of patients with CO poisoning or related symptoms during December 15 to 24, 2006. We grouped patients into households exposed concurrently to a single source of CO.
Results. Among 259 patients with CO poisoning, 204 cases were laboratory confirmed, 37 were probable, 10 were suspected, and 8 were fatal. Of 86 households studied, 58% (n=50) were immigrant households from Africa (n=21), Asia (n=15), Latin America (n=10), and the Middle East (n=4); 34% (n=29) were US-born households. One percent of households was European (n=1), and the origin for 7% (n=6) was unknown. Charcoal was the most common fuel source used among immigrant households (82%), whereas liquid fuel was predominant among US-born households (34%).
Conclusions. Educational campaigns to prevent CO poisoning should consider immigrants' cultural practices and languages and specifically warn against burning charcoal indoors and incorrect ventilation of gasoline- or propane-powered electric generators. (Am J Public Health. 2009;99:1687-1692. doi:10.2105/AJ PH.2008.143222)
C1 [Gulati, Reena K.] Univ Washington, Div Allergy & Infect Dis, Communicable Dis Epidemiol & Immunizat Sect, Seattle, WA 98195 USA.
[Gulati, Reena K.] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA USA.
[Hampson, Neil B.] Virginia Mason Med Ctr, Ctr Hyperbar Med, Seattle, WA 98101 USA.
[Shusterman, Dennis] Univ Washington, Occupat & Environm Med Program, Seattle, WA 98195 USA.
[Shandro, Jamie R.] Univ Washington, Harborview Med Ctr, Div Emergency Med, Seattle, WA 98195 USA.
RP Gulati, RK (reprint author), Univ Washington, Div Allergy & Infect Dis, Communicable Dis Epidemiol & Immunizat Sect, Box 356523, Seattle, WA 98195 USA.
EM rgulati@u.washington.edu
NR 22
TC 7
Z9 7
U1 0
U2 0
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
EI 1541-0048
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD SEP
PY 2009
VL 99
IS 9
BP 1687
EP 1692
DI 10.2105/AJPH.2008.143222
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 488FL
UT WOS:000269334500029
PM 19608962
ER
PT J
AU Davis, MV
Cannon, MM
Corso, L
Lenaway, D
Baker, EL
AF Davis, Mary V.
Cannon, Margaret M.
Corso, Liza
Lenaway, Dennis
Baker, Edward L.
TI Incentives to Encourage Participation in the National Public Health
Accreditation Model: A Systematic Investigation
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
AB Objectives. We sought to identify the incentives most likely to encourage voluntary participation in the national public health accreditation model.
Methods. We reviewed existing incentives, held meetings with key informants, and conducted a survey of state and local public health agency representatives. The survey was sent to all state health departments and a sample of local health departments. Group-specific differences in survey responses were examined.
Results. Survey response rates were 51% among state health department representatives and 49% among local health department representatives. Both state health department and local health department respondents rated financial incentives for accredited agencies, financial incentives for agencies considering accreditation, and infrastructure and quality improvement as important incentives. State health department respondents also indicated that grant administration and grant application would encourage their participation in the national accreditation model, and local health department respondents also noted that technical assistance and training would encourage their participation.
Conclusions. Incentives to encourage participation of state and local agencies in the national voluntary accreditation model should include financial support as well as support for agency infrastructure and quality improvements. Several initiatives are already under way to support agency infrastructure and quality improvement, but financial support incentives have yet to be developed. (Am J Public Health. 2009;99:1705-1711. doi:10.2105/AJPH.2008.151118)
C1 [Davis, Mary V.; Cannon, Margaret M.; Baker, Edward L.] Univ N Carolina, Gillings Sch Global Publ Hlth, N Carolina Inst Publ Hlth, Chapel Hill, NC 27599 USA.
[Corso, Liza; Lenaway, Dennis] Ctr Dis Control & Prevent, Off Chief Publ Hlth Practice, Atlanta, GA USA.
RP Davis, MV (reprint author), Univ N Carolina, Gillings Sch Global Publ Hlth, N Carolina Inst Publ Hlth, CB 8165, Chapel Hill, NC 27599 USA.
EM mary_davis@unc.edu
FU Centers for Disease Control and Prevention through its cooperative
agreement with the National Network of Public Health Institutes
FX This project was supported by funding from the Centers for Disease
Control and Prevention through its cooperative agreement with the
National Network of Public Health Institutes.; We thank Jennifer
McKeever of the National Network of Public Health Institutes for her
contributions to the project and J. Michael Bowling of the Gillings
School of Global Public Health, University of North Carolina, for his
analysis of survey data
NR 15
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U1 0
U2 4
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
EI 1541-0048
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD SEP
PY 2009
VL 99
IS 9
BP 1705
EP 1711
DI 10.2105/AJPH.2008.151118
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 488FL
UT WOS:000269334500032
PM 19608951
ER
PT J
AU Herrero, M
Orfanos, G
Argaw, D
Mulugeta, A
Aparicio, P
Parreno, F
Bernal, O
Rubens, D
Pedraza, J
Lima, MA
Flevaud, L
Palma, PP
Bashaye, S
Alvar, J
Bern, C
AF Herrero, Merce
Orfanos, Giannos
Argaw, Daniel
Mulugeta, Abate
Aparicio, Pilar
Parreno, Fernando
Bernal, Oscar
Rubens, Daniel
Pedraza, Jaime
Angeles Lima, Maria
Flevaud, Laurence
Pablo Palma, Pedro
Bashaye, Seife
Alvar, Jorge
Bern, Caryn
TI Natural History of a Visceral Leishmaniasis Outbreak in Highland
Ethiopia
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID KALA-AZAR; AMHARA REGION; HIV
AB In May 2005, visceral leishmaniasis (VL) was recognized for the first time in Libo Kemken, Ethiopia, a highland region where only few cases had been reported before. We analyzed records of VL patients treated from May 25, 2005 to December 13, 2007 by the only VL treatment center in the area, maintained by Medecins Sans Frontires-Ethiopia, Operational Center Barcelona-Athens. The median age was 18 years; 77.6% were male. The overall case fatality rate was 4%, but adults 45 years or older were five times as likely to die as 5-29 year olds. Other factors associated with increased mortality included HIV infection, edema, severe malnutrition, pneumonia, tuberculosis, and vomiting. The VL epidemic expanded rapidly over a several-year period, culminating in an epidemic peak in the last third of 2005, spread over two districts, and transformed into a sustained endemic situation by 2007.
C1 [Bern, Caryn] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Div Parasit Dis, Atlanta, GA 30341 USA.
[Herrero, Merce; Argaw, Daniel; Mulugeta, Abate] WHO, Dis Prevent & Control Programmes, UNECA Compound, Addis Ababa, Ethiopia.
[Parreno, Fernando; Bernal, Oscar; Angeles Lima, Maria; Flevaud, Laurence; Pablo Palma, Pedro] Med Sans Frontieres, Operat Ctr Barcelona Athens, Dept Med, Barcelona 0800, Spain.
[Aparicio, Pilar] Natl Ctr Trop Med, Inst Salud Carlos III, Madrid 28029, Spain.
[Rubens, Daniel] Mededins Sans Frontieres Argentina, RA-1022 Buenos Aires, DF, Argentina.
[Pedraza, Jaime] Med Sans Frontieres Holland, Dept Med, Bogota, Colombia.
[Alvar, Jorge] WHO, Control Neglected Trop Dis, CH-1211 Geneva 27, Switzerland.
RP Bern, C (reprint author), Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Div Parasit Dis, 4770 Buford Highway NE MS F-22, Atlanta, GA 30341 USA.
EM cxb9@cdc.gov
NR 14
TC 23
Z9 23
U1 0
U2 5
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD SEP
PY 2009
VL 81
IS 3
BP 373
EP 377
PG 5
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 487QW
UT WOS:000269290900002
PM 19706898
ER
PT J
AU Ramey, K
Eko, FO
Thompson, WE
Armah, H
Igietseme, JU
Stiles, JK
AF Ramey, Kiantra
Eko, Francis O.
Thompson, Winston E.
Armah, Henry
Igietseme, Joseph U.
Stiles, Jonathan K.
TI Immunolocalization and Challenge Studies Using a Recombinant Vibrio
cholerae Ghost Expressing Trypanosoma brucei Ca2+ ATPase (TBCA2) Antigen
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID P-TYPE ATPASES; EXPERIMENTAL AFRICAN TRYPANOSOMIASIS; INTERFERON-GAMMA;
CHLAMYDIA-TRACHOMATIS; CALCIUM HOMEOSTASIS; PARAFLAGELLAR ROD;
PLASMA-MEMBRANE; T-CELLS; INFECTION; CRUZI
AB Human African trypanosomiasis is a neglected disease caused by Trypanosoma brucei spp. A parasite cation pump (Ca2+ ATPase; TBCA2) essential for survival and cation homeostasis was identified and characterized. It was hypothesized that targeting this pump using a Vibrio cholerae ghost (VCG)-based vaccine could protect against murine T brucei infection. mRNA and protein expression of TBCA2 was differentially expressed in blood and insect stages of parasites and immunolocalized in the pericellular membrane and the flagellar pocket of bloodstream forms. Antigen-specific antibodies and Th1 cytokines, interleukin-2, interferon-gamma, and tumor necrosis factor-alpha were induced in rVCG-TBCA2-immunized mice and in vitro on antigen stimulation of splenic immune T cells, but the corresponding Th2-type response was unremarkable. Despite an increased median survival of 6 days in vaccinated mice, the mice were not protected against infection. Thus, immunization of mice produced robust parasite-specific antibodies but failed to protect mice against parasite challenge.
C1 [Ramey, Kiantra; Eko, Francis O.; Stiles, Jonathan K.] Morehouse Sch Med, Dept Microbiol Biochem & Immunol, Atlanta, GA 30310 USA.
[Thompson, Winston E.] Morehouse Sch Med, Dept Obstet & Gynecol, Atlanta, GA 30310 USA.
[Thompson, Winston E.] Morehouse Sch Med, Cooperat Reprod Sci Res Ctr, Atlanta, GA 30310 USA.
[Armah, Henry] Univ Pittsburgh, Dept Pathol, Med Ctr, Pittsburgh, PA 15261 USA.
[Igietseme, Joseph U.] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Sci Resources Program, Atlanta, GA 30333 USA.
RP Stiles, JK (reprint author), Morehouse Sch Med, Dept Microbiol Biochem & Immunol, BMSB Room 349D,720 Westview Dr SW, Atlanta, GA 30310 USA.
EM kramey@msm.edu; feko@msm.edu; wthomp-son@msm.edu; armahh2@upmc.edu;
jbi8@cdc.gov; jstiles@msm.edu
FU National Center for Research Resources, National Institutes of Health [1
C06 RR18386]; NIH-NIGMS-MBRS [S06GM08248]; NIH-RCMI [RR03034]
FX This study was conducted in a facility constructed with support from
Research Facilities Improvement Program Grant 1 C06 RR18386 from the
National Center for Research Resources, National Institutes of Health.
This work was supported by grants from NIH-NIGMS-MBRS (S06GM08248) and
NIH-RCMI (RR03034).
NR 57
TC 2
Z9 2
U1 0
U2 2
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD SEP
PY 2009
VL 81
IS 3
BP 407
EP 415
PG 9
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 487QW
UT WOS:000269290900009
PM 19706905
ER
PT J
AU Asnis, D
Kazakov, J
Toronjadze, T
Bern, C
Garcia, HH
McAuliffe, I
Bishop, H
Lee, L
Grossmann, R
Garcia, MA
Di John, D
AF Asnis, Deborah
Kazakov, Jordan
Toronjadze, Tamar
Bern, Caryn
Garcia, Hector H.
McAuliffe, Isabel
Bishop, Henry
Lee, Lillian
Grossmann, Rami
Garcia, Minerva A.
Di John, David
TI Case Report: Neurocysticercosis in the Infant of a Pregnant Mother with
a Tapeworm
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID IMPORTANT EMERGING INFECTION; UNITED-STATES; CYSTICERCOSIS; TAENIASIS
AB Tiaeniasis occurs after ingestion of undercooked pork infected with cysticerci. Most Taenia solium infections are mild; proglottids are rarely noticed in the feces. Cysticercosis develops with ingestion of eggs from a tapeworm carrier. Cysticercosis affects similar to 50 million people worldwide, and is seen mostly in Central and South America, sub-Saharan Africa, India, and Asia. We present a case of an 18-month-old child living in New York, who presented with seizures caused by neurocysticercosis. A family study found a 22-year-old mother, 7 months pregnant, positive for T solium, which presented a management dilemma.
C1 [Di John, David] Flushing Hosp & Med Ctr, Med Ctr, Dept Pediat, Flushing, NY 11355 USA.
[Bern, Caryn; McAuliffe, Isabel; Bishop, Henry] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA.
[Garcia, Hector H.] Univ Peruana Cayetano Heredia, Cysticercosis Unit, Inst Ciencias Neurol, Lima, Peru.
[Garcia, Hector H.] Univ Peruana Cayetano Heredia, Dept Microbiol, Lima, Peru.
[Lee, Lillian] New York City Dept Hlth & Mental Hyg, Publ Hlth Lab, New York, NY USA.
RP Di John, D (reprint author), Flushing Hosp & Med Ctr, Med Ctr, Dept Pediat, 4500 Parsons Blvd, Flushing, NY 11355 USA.
EM daviddijohn5l6@aol.com
NR 12
TC 11
Z9 11
U1 1
U2 2
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD SEP
PY 2009
VL 81
IS 3
BP 449
EP 451
PG 3
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 487QW
UT WOS:000269290900017
PM 19706913
ER
PT J
AU Tomashek, KM
Rivera, A
Munoz-Jordan, JL
Hunsperger, E
Santiago, L
Padro, O
Garcia, E
Sun, W
AF Tomashek, Kay M.
Rivera, Aidsa
Munoz-Jordan, Jorge L.
Hunsperger, Elizabeth
Santiago, Luis
Padro, Oscar
Garcia, Enid
Sun, Wellington
TI Description of a Large Island-Wide Outbreak of Dengue in Puerto Rico,
2007
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID LINKED-IMMUNOSORBENT-ASSAY; HEMORRHAGIC-FEVER; IMMUNE-RESPONSES; ALPHA
DEFICIENCY; IMMUNOGLOBULIN-G; VIRUS; INFECTION; EPIDEMIC; ESTROGEN;
MACROPHAGES
AB Dengue is a mosquito-borne viral disease that affects 40% of the world's population. Nearly four million U.S. citizens live in dengue-endemic areas; the most affected population resides in Puerto Rico. Data from a dengue surveillance system were used to describe all suspected cases reported in Puerto Rico in 2007. Rates of infection per 10,000 residents were calculated by age, sex, and residence. Rates and clinical outcomes were compared with those from outbreaks in 1994-1995 and 1998. In 2007, 10,508 suspected cases were reported; 52.5% persons were hospitalized, 31.8% reported hemorrhage, 2.2% had dengue hemorrhage fever, and 44 died. A total of 3,293 (33.0%) of processed specimens were laboratory positive for dengue virus (DENV); DENV-3 (1,342, 61.7%) and DENV-2 (677, 31.1%) were detected most often. The overall incidence of laboratory-positive dengue was 8.6 infections per 10,000 population. Rates were highest among persons 10-14 years of age (19.0), followed by persons 15-19 years of age (17.9) and infants (10.9). Higher rates of hospitalization and hemorrhage were reported in 2007 than in 1994-1995 or 1998. United States citizens residing in Puerto Rico are at risk of acquiring dengue. Data suggest that the severity is worsening, and persons 10-19 years of age and infants continue to be most affected.
C1 [Tomashek, Kay M.] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, San Juan, PR 00920 USA.
[Garcia, Enid] Puerto Rico Dept Hlth, San Juan, PR 00911 USA.
RP Tomashek, KM (reprint author), Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, 1324 Calle Canada, San Juan, PR 00920 USA.
EM ktomashek@cdc.gov
NR 56
TC 40
Z9 41
U1 0
U2 2
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD SEP
PY 2009
VL 81
IS 3
BP 467
EP 474
PG 8
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 487QW
UT WOS:000269290900021
PM 19706917
ER
PT J
AU Gurley, ES
Hossain, MJ
Montgomery, SP
Petersen, LR
Sejvar, JJ
Mayer, LW
Whitney, A
Dull, P
Nahar, N
Uddin, AKMR
Rahman, ME
Ekram, ARMS
Luby, SR
Breiman, RF
AF Gurley, Emily S.
Hossain, M. Jahangir
Montgomery, Susan P.
Petersen, Lyle R.
Sejvar, James J.
Mayer, Leonard W.
Whitney, Anne
Dull, Peter
Nahar, Nazmun
Uddin, A. K. M. Rafique
Rahman, M. Ekhlasur
Ekram, A. R. M. Saifuddin
Luby, Stephen R.
Breiman, Robert F.
TI Etiologies of Bacterial Meningitis in Bangladesh: Results from a
Hospital-Based Study
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID INFLUENZAE TYPE-B; INVASIVE PNEUMOCOCCAL DISEASE;
POLYMERASE-CHAIN-REACTION; REAL-TIME PCR; NEISSERIA-MENINGITIDIS;
DEVELOPING-COUNTRIES; CEREBROSPINAL-FLUID; SEEKING BEHAVIOR; CHILDREN;
ADULTS
AB We conducted a study at four hospitals from June 2003 to July 2005 to investigate the etiologies of bacterial meningitis in Bangladesh. A total of 2,609 patients met the clinical case definition, and 766 had cerebrospinal fluid tested by at least one of the following methods: latex agglutination, 16S rRNA gene sequencing, or real-time polymerase chain reaction for Neisseria meningitidis A and C, Streptococcus pneumoniae, and Haemophilus influenzae type b (Hib); culture results were noted from patient records. In total, 189 patients (24%) of those tested, representing all age groups, were diagnosed with bacterial meningitis; 136 (18%) had meningococcal, 23 (3%) had pneumococcal, and 25 (3%) had Hib infection. Twenty percent of patients with Hib meningitis (5/25) were > 15 years old. Case-fatality ratios were 10% for N. meningitidis, 22% for S. pneumoniae, and 24% for Hib. Bacterial meningitis from vaccine-prevent able pathogens causes significant morbidity and mortality in Bangladesh in adults and children.
C1 [Gurley, Emily S.; Hossain, M. Jahangir; Luby, Stephen R.] ICDDRB, Dhaka 1000, Bangladesh.
[Montgomery, Susan P.] DPD NCZVED CDC, Parasit Dis Branch, Atlanta, GA 30341 USA.
[Petersen, Lyle R.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA.
[Sejvar, James J.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA.
[Mayer, Leonard W.] Meningitis & Vaccine Preventable Dis Branch, Meningitis Lab, Atlanta, GA 30333 USA.
[Dull, Peter] Novartis Vaccines & Diagnost, Head Dev Meningococcal Vaccines, Cambridge, MA 02139 USA.
[Nahar, Nazmun] Bangladesh Inst Res & Rehabil Diabet Endocrine &, Dhaka 1000, Bangladesh.
[Uddin, A. K. M. Rafique] Specialist Doctors Ctr, Dhaka 1205, Bangladesh.
[Rahman, M. Ekhlasur] Dhaka Med Coll Hosp, Dept Paediat, Dhaka 1000, Bangladesh.
[Ekram, A. R. M. Saifuddin] Rajshahi Med Coll Hosp, Dept Med, Rajshahi 6000, Bangladesh.
[Breiman, Robert F.] CDC, KEMRI, Nairobi, Kenya.
RP Gurley, ES (reprint author), ICDDRB, GPO 128, Dhaka 1000, Bangladesh.
EM egurley@icddrb.org
RI Gurley, Emily/B-7903-2010
OI Gurley, Emily/0000-0002-8648-9403
FU Centers for Disease Control and Prevention
FX This study was funded by the Centers for Disease Control and Prevention.
NR 35
TC 9
Z9 11
U1 0
U2 1
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
EI 1476-1645
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD SEP
PY 2009
VL 81
IS 3
BP 475
EP 483
PG 9
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 487QW
UT WOS:000269290900022
PM 19706918
ER
PT J
AU Collins, WE
Jeffery, GM
Sullivan, JS
Nace, D
Williams, T
Gallaild, GG
Williams, A
Barnwell, JW
AF Collins, William E.
Jeffery, Geoffrey M.
Sullivan, Joann S.
Nace, Douglas
Williams, Tyrone
Gallaild, G. Gale
Williams, Allison
Barnwell, John W.
TI Infection of Mosquitoes with Plasmodium falciparum by Feeding on Humans
and on Aotus Monkeys
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID TROPHOZOITE-INDUCED INFECTIONS; SANTA-LUCIA STRAIN; RETROSPECTIVE
EXAMINATION; CLINICAL IMMUNITY; MODEL; VOCIFERANS; RESISTANCE; VACCINES
AB Of 1,004 positive lots of mosquitoes fed on 229 humans infected with Plasmodium falciparum, 46.2% had 1-10 oocysts/(+)gut, 21.2% had 10-30 oocysts/(+)gut, 22.2% had 30-100 oocysts/(+)gut, and 10.4% had >100 oocysts/(+) gut. The highest levels of infection occurred between 6 and 15 days after the peak in the asexual parasite count. Of 2,281 lots of Anopheles freeborni mosquitoes fed on splenectomized Aotus monkeys infected with the Santa Lucia strain of P. falciparum, 1,191 were infected (52.2%). The highest intensity infections ranged from 2.78 oocysts per positive gut in mosquitoes fed on Aotus vociferans to 6.08 oocysts per positive gut for those fed on A. lemurinus griseimembra to 10.4 oocysts per positive gut for those fed on A. nancymaae. The pattern of infection for mosquitoes fed on splenectomized Aotus monkeys was similar to that obtained by feeding on humans, but the intensity, based on oocyst/(+)gut, was much lower.
C1 Ctr Dis Control & Prevent, Anim Resources Branch, Natl Ctr Preparedness Detect & Control Infect Dis, US Publ Hlth Serv, Atlanta, GA 30333 USA.
Natl Ctr Vector Borne & Enter Dis, Natl Ctr Infect Dis, Div Parasit Dis, Atlanta, GA USA.
RP Collins, WE (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Mailstop F-36,4770 Buford Highway, Chamblee, GA 30341 USA.
EM wec1@cdc.gov
NR 19
TC 1
Z9 1
U1 1
U2 3
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD SEP
PY 2009
VL 81
IS 3
BP 529
EP 533
PG 5
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 487QW
UT WOS:000269290900031
PM 19706927
ER
PT J
AU Henningson, JN
Topliff, CL
Gil, LHV
Donis, RO
Steffen, DJ
Charleston, B
Eskridge, KM
Kelling, CL
AF Henningson, Jamie N.
Topliff, Christina L.
Gil, Laura H. V.
Donis, Ruben O.
Steffen, David J.
Charleston, Bryan
Eskridge, Kent M.
Kelling, Clayton L.
TI Effect of the viral protein N-pro on virulence of bovine viral diarrhea
virus and induction of interferon type I in calves
SO AMERICAN JOURNAL OF VETERINARY RESEARCH
LA English
DT Article; Proceedings Paper
CT 86th Conference of Research Workers in Animal Diseases
CY DEC, 2005
CL St Louis, MO
ID CLASSICAL SWINE-FEVER; REGULATORY FACTOR-3; PROTEASOMAL DEGRADATION;
SYSTEMIC INFECTION; INDUCED APOPTOSIS; PESTIVIRUS; PRODUCT; CELLS;
REPLICATION; 6-MONTH-OLD
AB Objective-To characterize the influence of the viral protein N-pro on virulence of bovine viral diarrhea virus (BVDV) and on type I interferon responses in calves.
Animals-10 calves, 4 to 6 months of age. Procedures-BVDV virulence and type I interferon responses of calves (n = 5) infected with a noncytopathic BVDV with a deleted N-pro were compared with those of calves (5) infected with a noncytopathic BVDV with a functional N-pro. Rectal temperatures, clinical signs, platelet counts, and total and differential WBC counts were evaluted daily. Histologic examinations and immunohistochemical analyses of tissues were conducted to assess lesions and distribution of viral antigens, respectively. Serum type I interferon concentrations were determined.
Results-Calves infected with N-pro-deleted BVDV developed leukopenia and lymphopenia, without developing increased rectal temperatures or lymphoid depletion of target lymphoid organs. There was minimal antigen deposition in lymphoid organs. Calves infected with N-pro BVDV developed increased rectal temperatures, leukopenia, lymphopenia, and lymphoid depletion with marked BVDV antigen deposition in lymphatic tissues. Interferon type I responses were detected in both groups of calves.
Conclusions and Clinical Relevance-Deletion of N-pro resulted in attenuation of BVDV as evidenced by reduced virulence in calves, compared with BVDV with a functional N-pro. Deletion of N-pro did not affect induction of type I interferon. The N-pro-deleted BVDV mutant may represent a safe noncytopathic virus candidate for vaccine development. (Am J Vet Res 2009;70:1117-1123)
C1 [Henningson, Jamie N.; Topliff, Christina L.; Steffen, David J.; Kelling, Clayton L.] Univ Nebraska, Coll Agr Sci & Nat Resources, Dept Vet & Biomed Sci, Lincoln, NE 68583 USA.
[Eskridge, Kent M.] Univ Nebraska, Coll Arts & Sci, Dept Stat, Lincoln, NE 68583 USA.
[Gil, Laura H. V.] Fundacao Osvaldo Cruz, Ctr Aggeu Magalhaes, BR-50670420 Recife, PE, Brazil.
[Donis, Ruben O.] CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Coordinating Ctr Infect Dis, Atlanta, GA 30333 USA.
[Charleston, Bryan] AFRC, Inst Anim Hlth, Pirbright Lab, Woking GU24 0NF, Surrey, England.
RP Kelling, CL (reprint author), Univ Nebraska, Coll Agr Sci & Nat Resources, Dept Vet & Biomed Sci, Lincoln, NE 68583 USA.
NR 38
TC 4
Z9 4
U1 0
U2 3
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0002-9645
J9 AM J VET RES
JI Am. J. Vet. Res.
PD SEP
PY 2009
VL 70
IS 9
BP 1117
EP 1123
PG 7
WC Veterinary Sciences
SC Veterinary Sciences
GA 489WP
UT WOS:000269456800008
PM 19719427
ER
PT J
AU Winnik, B
Barr, DB
Thiruchelvam, M
Montesano, MA
Richfield, EK
Buckley, B
AF Winnik, Bozena
Barr, Dana B.
Thiruchelvam, Mona
Montesano, M. Angela
Richfield, Eric K.
Buckley, Brian
TI Quantification of Paraquat, MPTP, and MPP+ in brain tissue using
microwave-assisted solvent extraction (MASE) and high-performance liquid
chromatography-mass spectrometry
SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY
LA English
DT Article
DE Paraquat; MPTP; MPP; Tissue; Microwave solvent extraction; HPLC; Mass
spectrometry; Electrospray ionization
ID ENVIRONMENTAL RISK-FACTORS; SOLID-PHASE EXTRACTION; PARKINSONS-DISEASE;
DOPAMINERGIC-NEURONS; MOUSE-BRAIN; EXPOSURE; PESTICIDES; MANEB; RATS;
MODELS
AB Animal models, consistent with the hypothesis of direct interaction of paraquat (PQ) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) with specific areas of the central nervous system have been developed to study Parkinson's disease (PD) in mice. These models have necessitated the creation of an analytical method for unambiguous identification and quantitation of PQ and structurally similar MPTP and 1-methyl-4-phenylpyridinium ion (MPP+) in brain tissue. A method for determination of these compounds was developed using microwave-assisted solvent extraction (MASE) and liquid chromatography-mass spectrometry. Extraction solvent and microwave conditions such as power and time were optimized to produce recoveries of 90% for PQ 78% for MPTP and 97% for its metabolite MPP+. The chromatographic separation was performed on a C8, column and detection was carried out using an ion trap as an analyzer with electrospray ionization. Mass spectrometer parameters such as heated capillary temperature, spray voltage, capillary voltage and others were also optimized for each analyte. Analysis was done in selective ion-monitoring (SIM) mode using m/z 186 for PQ, m/z 174 for MPTP, and m/z 170 for MPP+. The method detection limit for paraquat in matrix was 100 pg, 40 pg for MPTP, and 20 pg MPP+.
C1 [Winnik, Bozena; Buckley, Brian] Rutgers State Univ, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08854 USA.
[Barr, Dana B.; Montesano, M. Angela] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA.
[Thiruchelvam, Mona; Richfield, Eric K.] UMDNJ, Robert Wood Johnson Med Sch, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08822 USA.
RP Buckley, B (reprint author), Rutgers State Univ, Environm & Occupat Hlth Sci Inst, 170 Frelinghuysen Rd, Piscataway, NJ 08854 USA.
EM bbuckley@eohsi.rutgers.edu
RI Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013
FU NIH [ES005022]
FX This work was supported by NIH grant ES005022.
NR 23
TC 19
Z9 21
U1 1
U2 12
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1618-2642
J9 ANAL BIOANAL CHEM
JI Anal. Bioanal. Chem.
PD SEP
PY 2009
VL 395
IS 1
BP 195
EP 201
DI 10.1007/s00216-009-2929-z
PG 7
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 482EI
UT WOS:000268866800022
PM 19618168
ER
PT J
AU Dart, RC
Borron, SW
Caravati, EM
Cobaugh, DJ
Curry, SC
Falk, JL
Goldfrank, L
Gorman, SE
Groft, S
Heard, K
Miller, K
Olson, KR
O'Malley, G
Seger, D
Seifert, SA
Sivilotti, MLA
Schaeffer, T
Tomassoni, AJ
Wise, R
Bogdan, GM
Alhelail, M
Buchanan, J
Hoppe, J
Lavonas, E
Mlynarchek, S
Phua, DH
Rhyee, S
Varney, S
Zosel, A
AF Dart, Richard C.
Borron, Stephen W.
Caravati, E. Martin
Cobaugh, Daniel J.
Curry, Steven C.
Falk, Jay L.
Goldfrank, Lewis
Gorman, Susan E.
Groft, Stephen
Heard, Kennon
Miller, Ken
Olson, Kent R.
O'Malley, Gerald
Seger, Donna
Seifert, Steven A.
Sivilotti, Marco L. A.
Schaeffer, Tammi
Tomassoni, Anthony J.
Wise, Robert
Bogdan, Gregory M.
Alhelail, Mohammed
Buchanan, Jennie
Hoppe, Jason
Lavonas, Eric
Mlynarchek, Sara
Phua, Dong-Haur
Rhyee, Sean
Varney, Shawn
Zosel, Amy
CA Antidote Summit Authorship Grp
TI Expert Consensus Guidelines for Stocking of Antidotes in Hospitals That
Provide Emergency Care
SO ANNALS OF EMERGENCY MEDICINE
LA English
DT Article
ID POISONING ANTIDOTES; AVAILABILITY
AB Study objective: We developed recommendations for antidote stocking at hospitals that provide emergency care.
Methods: An expert panel representing diverse perspectives (clinical pharmacology, clinical toxicology, critical care medicine, clinical pharmacy, emergency medicine, internal medicine, pediatrics, poison centers, pulmonary medicine, and hospital accreditation) was formed to create recommendations for antidote stocking. Using a standardized summary of the medical literature, the primary reviewer for each antidote proposed guidelines for antidote stocking to the full panel. The panel used a formal iterative process to reach their recommendation for the quantity of an antidote that should be stocked and the acceptable period for delivery of each antidote.
Results: The panel recommended consideration of 24 antidotes for stocking. The panel recommended that 12 of the antidotes be available for immediate administration on patient arrival. In most hospitals, this period requires that the antidote be stocked in the emergency department. Another 9 antidotes were recommended for availability within 1 hour of the decision to administer, allowing the antidote to be stocked in the hospital pharmacy if the hospital has a mechanism for prompt delivery of antidotes. The panel identified additional antidotes that should be stocked by the hospital but are not usually needed within the first hour of treatment. The panel recommended that each hospital perform a formal antidote hazard vulnerability assessment to determine the need for antidote stocking in that hospital.
Conclusion: The antidote expert recommendations provide a tool to be used in creating practices for appropriate and adequate antidote stocking in hospitals that provide emergency care. [Ann Emerg Med. 2009;54:386-394.]
C1 [Dart, Richard C.; Heard, Kennon; Schaeffer, Tammi; Bogdan, Gregory M.; Alhelail, Mohammed; Buchanan, Jennie; Hoppe, Jason; Lavonas, Eric; Mlynarchek, Sara; Phua, Dong-Haur; Rhyee, Sean; Varney, Shawn; Zosel, Amy] Rocky Mt Poison & Drug Ctr Denver Hlth, Denver, CO USA.
[Borron, Stephen W.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.
[Caravati, E. Martin] Univ Utah, Hlth Sci Ctr, Utah Poison Control Ctr, Div Emergency Med, Salt Lake City, UT USA.
[Cobaugh, Daniel J.] ASHP Res & Educ Fdn, Bethesda, MD USA.
[Curry, Steven C.] Banner Good Samaritan Med Ctr, Dept Med Toxicol, Phoenix, AZ USA.
[Curry, Steven C.] Banner Good Samaritan Med Ctr, Banner Poison Control Ctr, Phoenix, AZ USA.
[Falk, Jay L.] Univ Florida, Dept Emergency Med, Orlando Reg Med Ctr, Orlando, FL USA.
[Goldfrank, Lewis] NYU, Sch Med, New York City Poison Ctr, New York, NY USA.
[Gorman, Susan E.] Ctr Dis Control & Prevent, Div Strateg Natl Stockpile, Atlanta, GA USA.
[Groft, Stephen] Off Rare Dis Res, Bethesda, MD USA.
[Dart, Richard C.; Heard, Kennon; Schaeffer, Tammi; Lavonas, Eric] Univ Colorado Denver, Sch Med, Div Emergency Med, Aurora, CO USA.
[Bogdan, Gregory M.] Univ Colorado Denver, Sch Pharm, Dept Pharmaceut Sci, Aurora, CO USA.
[Miller, Ken] Orange Cty Fire Author & Orange Cty Hlth Care Agc, Emergency Med Serv, Irvine, CA USA.
[Miller, Ken] Natl Assoc EMS Phys, Lenexa, KS USA.
[Olson, Kent R.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Olson, Kent R.] Calif Poison Control Syst, San Francisco Div, San Francisco, CA 94143 USA.
[O'Malley, Gerald] Albert Einstein Med Ctr, Dept Emergency Med, Div Res, Philadelphia, PA 19141 USA.
[Seger, Donna] Vanderbilt Univ, Div Clin Pharmacol, Dept Med, Tennessee Poison Ctr,Med Ctr, Nashville, TN USA.
[Seifert, Steven A.] Univ New Mexico, Sch Med & Med Director, New Mexico Poison & Drug Informat Ctr, Albuquerque, NM 87131 USA.
[Sivilotti, Marco L. A.] Queens Univ, Dept Emergency Med, Kingston, ON K7L 3N6, Canada.
[Sivilotti, Marco L. A.] Queens Univ, Dept Pharmacol & Toxicol, Kingston, ON K7L 3N6, Canada.
[Tomassoni, Anthony J.] Yale Univ, Sch Med, Dept Surg, Sect Emergency Med, New Haven, CT 06510 USA.
[Tomassoni, Anthony J.] Yale New Haven Ctr Emergency Preparedness & Disas, New Haven, CT USA.
[Wise, Robert] Int Joint Commiss, Div Stand & Survey Methods, Oak Brook Terrace, IL USA.
RP Dart, RC (reprint author), 777 Bannock St,Mailcode 0180, Denver, CO 80204 USA.
EM rdart@rmpdc.org
RI Siry, Bonnie/D-7189-2017
FU NIDA NIH HHS [K08 DA020573, K08 DA020573-03]
NR 23
TC 39
Z9 44
U1 1
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-0644
J9 ANN EMERG MED
JI Ann. Emerg. Med.
PD SEP
PY 2009
VL 54
IS 3
BP 386
EP 394
DI 10.1016/j.annemergmed.2009.01.023
PG 9
WC Emergency Medicine
SC Emergency Medicine
GA 488JM
UT WOS:000269345900016
PM 19406507
ER
PT J
AU Liu, YF
Li, YJ
Satten, GA
Allen, AS
Tzeng, JY
AF Liu, Youfang
Li, Yi-Ju
Satten, Glen A.
Allen, Andrew S.
Tzeng, Jung-Ying
TI A Regression-based Association Test for Case-control Studies that Uses
Inferred Ancestral Haplotype Similarity
SO ANNALS OF HUMAN GENETICS
LA English
DT Article
DE Case-control studies; haplotype similarity; haplotype sharing;
haplotype-based association test; covariates; regression-based
association analysis
ID LINKAGE-DISEQUILIBRIUM; DISEASE GENES; POPULATIONS; MUTATIONS; SEGMENTS;
TRAITS; POWER
AB Association methods based on haplotype similarity (HS) can overcome power and stability issues encountered in standard haplotype analyses. Current HS methods can be generally classified into evolutionary and two-sample approaches. We propose a new regression-based HS association method for case-control studies that incorporates covariate information and combines the advantages of the two classes of approaches by using inferred ancestral haplotypes. We first estimate the ancestral haplotypes of case individuals and then, for each individual, an ancestral-haplotype-based similarity score is computed by comparing that individual's observed genotype with the estimated ancestral haplotypes. Trait values are then regressed on the similarity scores. Covariates can easily be incorporated into this regression framework. To account for the bias in the raw p-values due to the use of case data in constructing ancestral haplotypes, as well as to account for variation in ancestral haplotype estimation, a permutation procedure is adopted to obtain empirical p-values. Compared with the standard haplotype score test and the multilocus T(2) test, our method improves power when neither the allele frequency nor linkage disequilibrium between the disease locus and its neighboring SNPs is too low and is comparable in other scenarios. We applied our method to the Genetic Analysis Workshop 15 simulated SNP data and successfully pinpointed a stretch of SNPs that covers the fine-scale region where the causal locus is located.
C1 [Liu, Youfang; Tzeng, Jung-Ying] N Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27569 USA.
[Li, Yi-Ju] Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC USA.
[Li, Yi-Ju; Allen, Andrew S.] Duke Univ, Med Ctr, Dept Biostat & Bioinformat, Durham, NC USA.
[Satten, Glen A.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Tzeng, JY (reprint author), N Carolina State Univ, Bioinformat Res Ctr, Campus Box 7566, Raleigh, NC 27569 USA.
EM jytzeng@stat.ncsu.edu
OI Tzeng, Jung-Ying/0000-0002-5505-1775; Satten, Glen/0000-0001-7275-5371
FU GAW [R01-GM031575]; NIH [5R01-HL049609-14, 1R01-AG021917-01A1,
R01MH084022-01A1]; University of Minnesota; Minnesota Supercomputing
Institute; NSF [0504726]
FX The authors thank the GAW grant, R01-GM031575, for providing the GAW 15
simulated data to be used in this study. Support for generation of the
GAW 15 simulated data is provided from NIH grants 5R01-HL049609-14,
1R01-AG021917-01A1, the University of Minnesota, and the Minnesota
Supercomputing Institute. Y.L. is partially supported by NSF DMS
0504726. J.Y.T is partially supported by NSF DMS 0504726 and NIH
R01MH084022-01A1.
NR 36
TC 3
Z9 3
U1 0
U2 1
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0003-4800
J9 ANN HUM GENET
JI Ann. Hum. Genet.
PD SEP
PY 2009
VL 73
BP 520
EP 526
DI 10.1111/j.1469-1809.2009.00536.x
PG 7
WC Genetics & Heredity
SC Genetics & Heredity
GA 481EF
UT WOS:000268789500006
PM 19622101
ER
PT J
AU Yoon, JJ
Krumm, SA
Ndungu, JM
Hoffman, V
Bankamp, B
Rota, PA
Sun, AM
Snyder, JP
Plemper, RK
AF Yoon, Jeong-Joong
Krumm, Stefanie A.
Ndungu, J. Maina
Hoffman, Vanessa
Bankamp, Bettina
Rota, Paul A.
Sun, Aiming
Snyder, James P.
Plemper, Richard K.
TI Target Analysis of the Experimental Measles Therapeutic AS-136A
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID DEPENDENT RNA-POLYMERASE; TRANSCRIPTASE INHIBITORS NNRTIS;
IMMUNODEFICIENCY-VIRUS TYPE-1; SENDAI-VIRUS; NONNUCLEOSIDE INHIBITORS;
REVERSE-TRANSCRIPTASE; PHOSPHOPROTEIN-P; IN-VITRO; RINDERPEST VIRUS;
ENTRY INHIBITORS
AB No effective therapeutic is currently in place for improved case management of severe measles or the rapid control of outbreaks. Through high-throughput screening, we recently identified a novel small-molecule class that potently blocks activity of the measles virus (MeV) RNA-dependent RNA polymerase (RdRp) complex in transient replicon assays. However, the nature of the block in RdRp activity and the physical target of the compound remained elusive. Through real-time reverse transcription-PCR analysis, we demonstrate that the lead compound AS-136A blocks viral RNA synthesis in the context of an infection. Adaptation of different MeV strains to growth in the presence of the compound identified three candidate hot spots for resistance that are located in conserved domains of the viral polymerase (L protein) subunit of the RdRp complex. Rebuilding of individual mutations in RdRp-driven reporter assays and recombinant MeV traced the molecular basis for resistance to specific mutations in L. Mutations responsible for resistance cluster in the immediate vicinity of the proposed catalytic center for phosphodiester bond formation and neighboring conserved domains of L, providing support for effective inhibition of a paramyxovirus RdRp complex through interaction of a non-nucleoside small-molecule inhibitor with the L protein. Resistance mutations are located in regions of L that are fully conserved among viral isolates, and recombinant MeV harboring individual resistance mutations show some delay in the onset of viral growth in vitro. Taken together, these data support the hypothesis that acquiring mutations in these L domains may reduce virus fitness.
C1 [Plemper, Richard K.] Emory Univ, Sch Med, Dept Pediat, Div Infect Dis, Atlanta, GA 30322 USA.
[Yoon, Jeong-Joong; Krumm, Stefanie A.; Hoffman, Vanessa; Plemper, Richard K.] Childrens Healthcare Atlanta, Atlanta, GA 30322 USA.
[Ndungu, J. Maina] Emory Univ, Dept Chem, Atlanta, GA 30322 USA.
[Bankamp, Bettina; Rota, Paul A.; Sun, Aiming; Snyder, James P.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA.
[Plemper, Richard K.] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA.
RP Plemper, RK (reprint author), Emory Univ, Sch Med, Dept Pediat, Div Infect Dis, 520 Childrens Ctr,2015 Uppergate Dr, Atlanta, GA 30322 USA.
EM rplempe@emory.edu
FU U.S. Public Health Service [AI071002]; NIH/NIAID
FX We thank A. L. Hammond for critical reading of the manuscript. This work
was supported by U.S. Public Health Service grant AI071002 ( to R. K.
P.) from the NIH/NIAID.
NR 58
TC 17
Z9 17
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD SEP
PY 2009
VL 53
IS 9
BP 3860
EP 3870
DI 10.1128/AAC.00503-09
PG 11
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 496XR
UT WOS:000270014200033
PM 19528268
ER
PT J
AU Gentry, J
Vinje, J
Guadagnoli, D
Lipp, EK
AF Gentry, Jennifer
Vinje, Jan
Guadagnoli, Dominic
Lipp, Erin K.
TI Norovirus Distribution within an Estuarine Environment
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID REVERSE TRANSCRIPTION-PCR; NORWALK-LIKE VIRUSES; CRASSOSTREA-GIGAS;
GENETIC-ANALYSIS; ENTERIC VIRUSES; UNITED-STATES; GENOGROUPS I;
WASTE-WATER; GASTROENTERITIS; SHELLFISH
AB Human norovirus (NoV) has been studied extensively as an important cause of gastroenteritis outbreaks worldwide. While oysters are a primary vehicle for infection, few studies have examined the wider distribution of NoV in the estuarine environment. Active shellfish-harvesting areas in Georgia were examined for the prevalence, genotype diversity, and concentrations of NoV in a variety of estuarine sample types over the course of 1 year. Of the 225 samples (9 oyster, 72 water, 72 63- to 200-mu m plankton, and 72 > 200-mu m plankton) collected from 12 stations across two estuaries, 21 samples (9.3%) tested positive for NoV. By sample type, 55.0% (5/9) of oysters, 8.3% (6/72) of water samples, 11.1% (8/72) of 63- to 200-mu m plankton samples, and 2.8% (2/72) of > 200-mu m plankton samples were positive for human NoV. The two NoV-positive > 200-mu m plankton ;samples, which contained mainly zooplankton, had the greatest quantity of NoV genomes (3.5 x 10(13) and 1.7 x 10(15) genomes g(-1)) of any sample tested. The majority, 90.5% (19/21), of the samples tested positive for genogroup I NoV, and only 9.5% (2/21) of the samples tested positive for genogroup II. The high concentrations of NoV in plankton samples compared to water and oyster samples were unexpected and provide new insights into the presence and distribution of human NoV in the water environment.
C1 [Gentry, Jennifer; Lipp, Erin K.] Univ Georgia, Dept Environm Hlth Sci, Athens, GA 30602 USA.
[Vinje, Jan] Ctr Dis Control & Prevent, NCIRD, DVD, GRVLB, Atlanta, GA 30333 USA.
[Guadagnoli, Dominic] Georgia Dept Nat Resources, Coastal Resources Div, Brunswick, GA 31520 USA.
RP Lipp, EK (reprint author), Univ Georgia, Dept Environm Hlth Sci, 206 Environm Hlth Sci Bldg, Athens, GA 30602 USA.
EM elipp@uga.edu
OI Vinje, Jan/0000-0002-1530-3675
FU National Oceanic and Atmospheric Administration Oceans and Human Health
Initiative [NA04OAR4600203]
FX This work was supported by National Oceanic and Atmospheric
Administration Oceans and Human Health Initiative grant no.
NA04OAR4600203.
NR 46
TC 46
Z9 49
U1 0
U2 17
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD SEP 1
PY 2009
VL 75
IS 17
BP 5474
EP 5480
DI 10.1128/AEM.00111-09
PG 7
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 488JA
UT WOS:000269344200006
PM 19581478
ER
PT J
AU Violanti, JM
Burchfiel, CM
Hartley, TA
Mnatsakanova, A
Fekedulegn, D
Andrew, ME
Charles, LE
Vila, BJ
AF Violanti, John M.
Burchfiel, Cecil M.
Hartley, Tara A.
Mnatsakanova, Anna
Fekedulegn, Desta
Andrew, Michael E.
Charles, Luenda E.
Vila, Bryan J.
TI Atypical Work Hours and Metabolic Syndrome Among Police Officers
SO ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
LA English
DT Article
DE cardiovascular disease; overtime; police officers; shift work; sleep
ID ACUTE MYOCARDIAL-INFARCTION; ISCHEMIC-HEART-DISEASE; SHIFT WORK;
OVERTIME WORK; MORTALITY; SLEEP; RISK; HEALTH; COHORT; ADULTS
AB This Study examined whether atypical work hours are associated with metabolic syndrome among a random sample of 98 police officers. Shift work and overtime data from daily payroll records and reported sleep duration were obtained. Metabolic syndrome was defined as elevated waist circumference and triglycerides, low HDL cholesterol, hypertension, and glucose intolerance. Multivariate analysis of variance and analysis of covariance models were used for analyses. Officers working midnight shifts were on average younger and had a slightly higher mean number of metabolic syndrome components. Stratification oil sleep duration and overtime revealed significant associations between midnight shifts and the mean number of metabolic syndrome components among officers with less sleep (p = .013) and more overtime (p = .007). Results Suggest shorter sleep duration and more overtime combined with midnight shift work may be important contributors to the metabolic syndrome.
C1 [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Social & Prevent Med, Buffalo, NY 14214 USA.
[Burchfiel, Cecil M.; Hartley, Tara A.; Mnatsakanova, Anna; Fekedulegn, Desta; Andrew, Michael E.; Charles, Luenda E.] NIOSH, Hlth Effects Lab Div, Biostat & Epidemiol Branch, Ctr Dis Control & Prevent, Morgantown, WV USA.
[Vila, Bryan J.] Washington State Univ, Criminal Justice Program, Spokane, WA USA.
[Vila, Bryan J.] Washington State Univ, Sleep & Performance Res Ctr, Spokane, WA USA.
RP Violanti, JM (reprint author), SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Social & Prevent Med, 270 Farber Hall, Buffalo, NY 14214 USA.
EM violanti@buffalo.edu
RI Charles, Luenda/H-6008-2011
FU National Institute for Occupational Safety and Health [IR03OH003772-01]
FX This research was supported by the National Institute for Occupational
Safety and Health (IR03OH003772-01). The findings and conclusions in
this report are those of the authors and do not necessarily represent
the official position of the Centers for Disease Control and Prevention.
NR 37
TC 47
Z9 49
U1 3
U2 15
PU HELDREF PUBLICATIONS
PI WASHINGTON
PA 1319 EIGHTEENTH ST NW, WASHINGTON, DC 20036-1802 USA
SN 1933-8244
J9 ARCH ENVIRON OCCUP H
JI Arch. Environ. Occup. Health
PD FAL
PY 2009
VL 64
IS 3
BP 194
EP 201
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 519MU
UT WOS:000271771600009
PM 19864222
ER
PT J
AU Freedman, DS
Wang, J
Thornton, JC
Mei, ZG
Sopher, AB
Pierson, RN
Dietz, WH
Horlick, M
AF Freedman, David S.
Wang, Jack
Thornton, John C.
Mei, Zuguo
Sopher, Aviva B.
Pierson, Richard N., Jr.
Dietz, William H.
Horlick, Mary
TI Classification of Body Fatness by Body Mass Index-for-Age Categories
Among Children
SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
LA English
DT Article
ID X-RAY ABSORPTIOMETRY; CARDIOVASCULAR RISK-FACTORS; WHITE-CHILDREN;
ADOLESCENT OVERWEIGHT; EXPERT COMMITTEE; AFRICAN-AMERICAN;
BLOOD-PRESSURE; FOLLOW-UP; OBESITY; FAT
AB Objective: To examine the ability of various body mass index (BMI)-for-age categories, including the Centers for Disease Control and Prevention's 85th to 94th percentiles, to correctly classify the body fatness of children and adolescents.
Design: Cross-sectional.
Setting: The New York Obesity Research Center at St Luke's-Roosevelt Hospital from 1995 to 2000.
Participants: Healthy 5- to 18-year-old children and adolescents (N = 1196) were recruited in the New York City area through newspaper notices, announcements at schools and activity centers, and word of mouth.
Main Outcome Measures: Percent body fat as determined by dual-energy x-ray absorptiometry. Body fatness cutoffs were chosen so that the number of children in each category (normal, moderate, and elevated fatness) would equal the number of children in the corresponding BMI-for-age category (<85th percentile, 85th-94th percentile, and >= 95th percentile, respectively).
Results: About 77% of the children who had a BMI for age at or above the 95th percentile had an elevated body fatness, but levels of body fatness among children who had a BMI for age between the 85th and 94th percentiles (n = 200) were more variable; about one-half of these children had a moderate level of body fatness, but 30% had a normal body fatness and 20% had an elevated body fatness. The prevalence of normal levels of body fatness among these 200 children was highest among black children (50%) and among those within the 85th to 89th percentiles of BMI for age (40%).
Conclusion: Body mass index is an appropriate screening test to identify children who should have further evaluation and follow-up, but it is not diagnostic of level of adiposity.
C1 [Freedman, David S.; Mei, Zuguo; Dietz, William H.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA.
[Wang, Jack; Thornton, John C.; Sopher, Aviva B.; Pierson, Richard N., Jr.] Columbia Univ, St Lukes Roosevelt Hosp, Body Composit Unit, Dept Med,New York Obes Res Ctr,Med Ctr, New York, NY USA.
[Sopher, Aviva B.] Columbia Univ, Dept Pediat, Morgan Stanley Childrens Hosp New York, Med Ctr, New York, NY 10027 USA.
[Horlick, Mary] NIDDK, Bethesda, MD USA.
RP Freedman, DS (reprint author), Ctr Dis Control & Prevent, Div Nutr & Phys Act, CDC Mailstop K-26,4770 Buford Hwy, Atlanta, GA 30341 USA.
EM dfreedman@cdc.gov
FU National Institutes of Health [DK37352]
FX This study was supported by grant DK37352 from the National Institutes
of Health.
NR 41
TC 48
Z9 53
U1 0
U2 2
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 1072-4710
J9 ARCH PEDIAT ADOL MED
JI Arch. Pediatr. Adolesc. Med.
PD SEP
PY 2009
VL 163
IS 9
BP 805
EP 811
PG 7
WC Pediatrics
SC Pediatrics
GA 491PC
UT WOS:000269590300005
PM 19736333
ER
PT J
AU Nguyen, PH
Grajeda, R
Melgar, P
Marcinkevage, J
DiGirolamo, AM
Flores, R
Martorell, R
AF Nguyen, Phuong H.
Grajeda, Ruben
Melgar, Paul
Marcinkevage, Jessica
DiGirolamo, Ann M.
Flores, Rafael
Martorell, Reynaldo
TI Micronutrient supplementation may reduce symptoms of depression in
Guatemalan women
SO ARCHIVOS LATINOAMERICANOS DE NUTRICION
LA English
DT Article
DE Depression; folate; micronutrients; randomized controlled trial; women
of reproductive age; Guatemala
ID FOLIC-ACID SUPPLEMENTATION; POSTPARTUM DEPRESSION; VITAMIN-B-12
DEFICIENCY; DIETARY-FOLATE; HOMOCYSTEINE; POPULATION; SERUM; MOOD; RISK;
ZINC
AB Evidence for the impact of micronutrient supplementation trials on depression in women from developing countries is limited. This study examines this association and compares the impact of weekly versus daily combinations of micronutrient supplements on symptoms of depression. A randomized, positive-controlled trial was conducted in Guatemala. A total of 459 women were assigned randomly to 4 groups to receive weekly (5,000 or 2,800 mu g) or daily (400 or 200 mu g) folic acid (FA) plus iron, zinc and vitamin B-12 for 12 weeks. Depression was measured using the Center for Epidemiologic Studies-Depression 20-item Scale (CES-D). A score=16 was used as an indication of depression. The association between micronutrient status and depression was assessed using baseline data. Generalized linear regression models were used to assess treatment effects. The baseline mean CES-D score was 17.1 +/- 8.5 and the prevalence of depression was 49.3%. Women in the lowest tertile of red blood cell folate (RBC) were 1.7 times more likely to be depressed than those in the highest tertile (OR=1.71; 95% CI: 0.91, 3.18). There were no associations between depression and serum folate, homocysteine, vitamin B-12, hemoglobin, ferritin or zinc (p > 0.05). Mean depression scores decreased by 2.3 points post-intervention and depression decreased to 37.7%. with no differences in degree of improvement by group (p = 0.64). Low RBC folate was associated with elevated symptoms of depression at baseline. Supplementation with FA-containing micronutrients may be equally efficacious in improving symptoms of depression when provided daily or weekly. Our findings that poor folate status may increase depression needs to be further investigated.
C1 [Nguyen, Phuong H.] Emory Univ, Atlanta, GA 30322 USA.
Pan Amer Hlth Org, Washington, DC USA.
Ctr Dis Control & Prevent, Inst Nutr Cent Amer & Panama Guatemala, Chamblee, GA USA.
RP Nguyen, PH (reprint author), Emory Univ, Atlanta, GA 30322 USA.
RI Martorell, Reynaldo /I-2539-2012
NR 60
TC 15
Z9 16
U1 1
U2 7
PU ARCHIVOS LATINOAMERICANOS NUTRICION
PI CARACAS
PA APARTADO 62778 CHACAO, AVENIDA FRANCISCO MIRANDA, CARACAS 1060,
VENEZUELA
SN 0004-0622
J9 ARCH LATINOAM NUTR
JI Arch. Latinoam. Nutr.
PD SEP
PY 2009
VL 59
IS 3
BP 278
EP 286
PG 9
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 515OF
UT WOS:000271481000008
PM 19886513
ER
PT J
AU Li, Z
Porter, EN
Sjodin, A
Needham, LL
Lee, S
Russell, AG
Mulholland, JA
AF Li, Zheng
Porter, Erin N.
Sjoedin, Andreas
Needham, Larry L.
Lee, Sangil
Russell, Armistead G.
Mulholland, James A.
TI Characterization of PM2.5-bound polycyclic aromatic hydrocarbons in
Atlanta-Seasonal variations at urban, suburban, and rural ambient air
monitoring sites
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Polycyclic aromatic hydrocarbon; PAH; Seasonal variation; Spatial
variation; Retene
ID SOURCE-APPORTIONMENT; WOOD COMBUSTION; RISK-ASSESSMENT; FINE-PARTICLE;
PAHS; CITY; POLLUTION; POLLUTANTS; GUANGZHOU; PM2.5
AB Twenty-eight polycyclic aromatic hydrocarbons (PAH) and methylated PAHs (Me-PAH) were measured in daily PM2.5 samples collected at an urban site, a suburban site, and a rural site in and near Atlanta during 2004 (5 samples/month/site). The suburban site. located near a major highway, had higher PM2.5-bound. PAH concentrations than did the urban site, and the rural site had the lowest PAH levels. Monthly variations are described for concentrations of total PAHs (Sigma PAHs) and individual PAHs. PAH concentrations were much higher in cold months than in warm months, with average monthly Sigma PAH concentrations at the urban and suburban-highway monitoring sites ranging from 2.12 to 6.85 ng m(-3) during January-February and November-December 2004, compared to 0.38-0.98 ng m(-3) during May-September 2004. Sigma PAH concentrations were found to be well correlated with PM2.5 and organic carbon (OC) within seasons, and the fractions of PAHs in PM2.5 and OC were higher in winter than in summer. Methyl phenanthrenes were present at higher levels than their un-substituted homologue (phenanthrene), suggesting a petrogenic (unburned petroleum products) input. Retene, a proposed tracer for biomass burning, peaked in March, the month with the highest acreage and frequency of prescribed burning and unplanned fires, and in December, during the high residential wood-burning season. indicating that retene might be a good marker for burning of all biomass materials. In contrast. potassium peaked only in December, indicating that it might be a more specific tracer for wood-burning. Published by Elsevier Ltd.
C1 [Li, Zheng; Porter, Erin N.; Sjoedin, Andreas; Needham, Larry L.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
[Li, Zheng; Russell, Armistead G.; Mulholland, James A.] Georgia Inst Technol, Sch Environm & Civil Engn, Atlanta, GA 30332 USA.
[Lee, Sangil] Korea Res Inst Stand & Sci, Measurement Support Ctr, Div Qual Life, Taejon 305340, South Korea.
RP Li, Z (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway F-53, Atlanta, GA 30341 USA.
EM ZhengJLi@cdc.gov
RI Needham, Larry/E-4930-2011; Sjodin, Andreas/F-2464-2010
NR 46
TC 56
Z9 61
U1 5
U2 37
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD SEP
PY 2009
VL 43
IS 27
BP 4187
EP 4193
DI 10.1016/j.atmosenv.2009.05.031
PG 7
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 487PU
UT WOS:000269288100009
ER
PT J
AU Reed, LM
Johansson, MA
Panella, N
McLean, R
Creekmore, T
Puelle, R
Komar, N
AF Reed, Lisa M.
Johansson, Michael A.
Panella, Nicholas
McLean, Robert
Creekmore, Terry
Puelle, Rose
Komar, Nicholas
TI Declining Mortality in American Crow (Corvus brachyrhynchos) Following
Natural West Nile Virus Infection
SO AVIAN DISEASES
LA English
DT Article
DE West Nile virus; crows; corvids; seroprevalence; infection; mortality
ID NEW-YORK-STATE; UNITED-STATES; SURVEILLANCE; BIRDS; EMERGENCE; COLORADO;
OSSIFRAGUS
AB The American crow (Corvus brachyrhynchos) is known to suffer 100% mortality from infection with the New York 1999 strain of West Nile virus (WNV). Following the initial detection of WNV in North America in 1999, we measured prevalence of WNV-reactive antibodies ("seroprevalence") in free-ranging American and fish crows (Corvus ossifragus) of central New Jersey after each transmission season through 2005. In 2002, seroprevalence in American crow juveniles increased to 14% from the 5% of the previous year, potentially indicating increased survival in this species. Using the annual seroprevalence measurements and the number of human West Nile neuroinvasive disease cases as a surrogate for WNV transmission intensity, we developed a model to estimate the annual WNV-associated mortality rates among both of these crow species. Our model supports the hypothesis that mortality is changing over time; the WNV-associated mortality rate declined over time by 1.5% for American crow and by 1.1% for fish crow. The probability that the trend in mortality was negative was 90% for the American crow and 60% for the fish crow.
C1 [Reed, Lisa M.] Rutgers State Univ, Ctr Vector Biol, New Brunswick, NJ 08901 USA.
[Johansson, Michael A.; Panella, Nicholas; Komar, Nicholas] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA.
[McLean, Robert] USDA, Wildlife Dis Res Program, Natl Wildlife Res Ctr, Ft Collins, CO 80521 USA.
[Creekmore, Terry] Wyoming Game & Fish, Wildlife Div, Laramie, WY 82070 USA.
[Puelle, Rose] Publ Hlth, Publ Hlth Preparedness, Hunterdon Cty, NJ 08822 USA.
RP Reed, LM (reprint author), Rutgers State Univ, Ctr Vector Biol, 180 Jones Ave, New Brunswick, NJ 08901 USA.
EM lreed@rci.rutgers.edu
FU State Mosquito Control Commission of the New Jersey Department of
Environmental Protection; Centers for Disease Control and Prevention;
New Jersey Department of Health and Senior Services; Equine Science
Center of the School for Environmental and Biological Sciences, Rutgers
University
FX We thank Robert Anderson, Priscilla Collins, Vivien Roegner, Kelsey
Brooks, Ryan Neary, Bevin O'Grady, and Steve Piotrowski for technical
assistance. Wayne Crans provided helpful suggestions on the manuscript.
Marm Kilpatrick, Brad Biggerstaff, and Mark Delorey provided advice on
data analysis. Funding was provided from the State Mosquito Control
Commission of the New Jersey Department of Environmental Protection, the
Centers for Disease Control and Prevention, the New Jersey Department of
Health and Senior Services, and the Equine Science Center of the School
for Environmental and Biological Sciences, Rutgers University. This is
New Jersey Agricultural Experiment Station publication number
D-08-08294-08-09.
NR 35
TC 11
Z9 11
U1 1
U2 22
PU AMER ASSOC AVIAN PATHOLOGISTS
PI ATHENS
PA 953 COLLEGE STATION RD, ATHENS, GA 30602-4875 USA
SN 0005-2086
J9 AVIAN DIS
JI Avian Dis.
PD SEP
PY 2009
VL 53
IS 3
BP 458
EP 461
PG 4
WC Veterinary Sciences
SC Veterinary Sciences
GA 501OA
UT WOS:000270390000022
PM 19848089
ER
PT J
AU Ramadhani, T
Short, V
Canfield, MA
Waller, DK
Correa, A
Royle, M
Scheuerle, A
AF Ramadhani, Tunu
Short, Vanessa
Canfield, Mark A.
Waller, D. Kim
Correa, Adolfo
Royle, Marjorie
Scheuerle, Angela
CA Natl Birth Defects Prevention
TI Are Birth Defects among Hispanics Related to Maternal Nativity or Number
of Years Lived in the United States?
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Article; Proceedings Paper
CT Texas Birth Defects Research Symposium 2008
CY OCT 17, 2008
CL Lubbock, TX
DE birth defects; nativity; immigration; Hispanic; country
ID NEURAL-TUBE DEFECTS; CONGENITAL-MALFORMATIONS; AFFECTED PREGNANCIES;
MEXICAN DESCENT; CALIFORNIA; RISK; WOMEN; TEXAS; BORN; POPULATIONS
AB BACKGROUND: Literature on the risk of birth defects among foreign- versus U.S.-born Hispanics is limited or inconsistent. We examined the association between country of birth, immigration patterns, and birth defects among Hispanic mothers. METHODS: We used data from the National Birth Defects Prevention Study and calculated odds ratios (ORs) and 95% confidence intervals and assessed the relationship between mothers' country of birth, years lived in the United States, and birth defects among 575 foreign-born compared to 539 U.S.-born Hispanic mothers. RESULTS: Hispanic mothers born in Mexico/Central America were more likely to deliver babies with spina bifida (OR = 1.53) than their U.S.-born counterparts. Also, mothers born in Mexico/Central America or who were recent United States immigrants (<= 5 years) were less likely to deliver babies with all atrial septal defects combined, all septal defects combined, or atrial septal defect, securidum type. However, Hispanic foreign-born mothers who lived in the United States for >5 years were more likely to deliver babies with all neural tube defects combined (OR = 1.42), spina bificla (OR = 1.89), and longitudinal limb defects (OR = 2.34). Foreign-born mothers, regardless of their number of years lived in the United States, were more likely to deliver babies with anotia or microtia. CONCLUSIONS: Depending on the type of birth defect, foreign-born Hispanic mothers might be at higher or lower risk of delivering babies with the defects. The differences might reflect variations in predisposition, cultural norms, behavioral characteristics, and/or ascertainment of the birth defects. Birth Defects Research (Part A) 85:755-763, 2009. (C) 2009 Wiley-Liss, Inc.
C1 [Ramadhani, Tunu; Short, Vanessa; Canfield, Mark A.] Texas Dept State Hlth Serv, Birth Defects Epidemiol & Surveillance Branch, Austin, TX USA.
[Waller, D. Kim] Univ Texas Houston, Hlth Sci Ctr, Sch Publ Hlth, Houston, TX USA.
[Correa, Adolfo] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Royle, Marjorie] New Jersey Dept Hlth & Senior Serv, Trenton, NJ USA.
[Scheuerle, Angela] Tesserae Genet, Dallas, TX USA.
RP Ramadhani, T (reprint author), Texas Dept State Hlth Serv, Birth Defects Epidemiol & Surveillance Branch, 1100 W 49th St, Austin, TX USA.
EM tunu.loponi@dshs.state.tx.us
RI Publications, NBDPS/B-7692-2013
FU PHS HHS [U50/CCU613232]
NR 21
TC 14
Z9 14
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD SEP
PY 2009
VL 85
IS 9
BP 755
EP 763
DI 10.1002/bdra.20584
PG 9
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 504AY
UT WOS:000270586400002
PM 19350653
ER
PT J
AU Robitaille, J
Carmichael, SL
Shaw, GM
Olney, RS
AF Robitaille, Julie
Carmichael, Suzan L.
Shaw, Gary M.
Olney, Richard S.
CA Natl Birth Defects Prevention
TI Maternal Nutrient Intake and Risks for Transverse and Longitudinal Limb
Deficiencies: Data from the National Birth Defects Prevention Study,
1997-2003
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Article; Proceedings Paper
CT 48th Annual Meeting of the Teratology-Society
CY JUN 28-JUL 02, 2008
CL Monterey, CA
SP Teratol Soc
DE congenital; limb deficiencies; riboflavin; folic acid; vitamin B-6
ID METHYLENETETRAHYDROFOLATE REDUCTASE; MULTIVITAMIN SUPPLEMENTATION;
CONGENITAL-MALFORMATIONS; VASCULAR PATHOGENESIS; UNITED-STATES; OBESITY;
AVERSIONS; ANOMALIES; CRAVINGS; INFANTS
AB BACKGROUND: The association between periconceptional intake of supplements containing folic acid with specific subtypes of limb deficiencies has been inconsistent. The objective was to investigate whether intake of nutrients involved in one-carbon metabolism (folate, vitamin B-6, vitamin B-12, riboflavin, choline, betaine, zinc, and methionine) through diet alone or in combination with a supplement containing folic acid influenced the risk for transverse limb deficiency (TLD) and longitudinal limb deficiency (LLD). METHODS: We analyzed 1997-2003 data from the National Birth Defects Prevention Study and included 324 case infants with TLD, 158 case infants with LLD, and 4982 nonmalformed control infants. A food frequency questionnaire was used to estimate nutrient intakes. Use of supplements containing folic acid 1 month before through 2 months after conception was recorded. RESULTS: Use of a supplement containing folic acid was not associated with LLD or TLD. For nonsupplement users, within (1) the lowest quartile of dietary folate intake or vitamin B-6 intake, adjusted odds ratios (aORs) for LLD were, respectively, 3.86 (95% confidence interval [CI]: 1.08-13.78) and 4.36 (95% CI: 0.93-20.48); and (2) the lowest quartile for riboflavin intake, the aOR for TLD was 2.94 (95% CI: 1.04-8.32). For supplement users within the lowest quartile of folate intake or riboflavin intake, the aORs for TLD were, respectively, 1.52 (95% CI: 0.91-2.54) and 1.54 (95% CI: 1.00-2.37). CONCLUSIONS: TLD and LLD were not associated with supplement use, but TLD was associated with low intakes of riboflavin from diet. Birth Defects Research (Part A) 85:773-779, 2009. (C) 2009 Wiley-Liss, Inc.
C1 [Robitaille, Julie; Olney, Richard S.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Robitaille, Julie] Univ Laval, Dept Food Sci & Nutr, Quebec City, PQ, Canada.
[Carmichael, Suzan L.; Shaw, Gary M.] March Dimes Fdn, Calif Res Div, Oakland, CA USA.
RP Olney, RS (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA.
EM rolney@cdc.gov
RI Publications, NBDPS/B-7692-2013; Robitaille, Julie/O-4892-2016
OI Robitaille, Julie/0000-0001-7035-0477
NR 34
TC 11
Z9 12
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD SEP
PY 2009
VL 85
IS 9
BP 773
EP 779
DI 10.1002/bdra.20587
PG 7
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 504AY
UT WOS:000270586400004
PM 19350655
ER
PT J
AU Trivers, KF
Lund, MJ
Porter, PL
Liff, JM
Flagg, EW
Coates, RJ
Eley, JW
AF Trivers, Katrina F.
Lund, Mary Jo
Porter, Peggy L.
Liff, Jonathan M.
Flagg, Elaine W.
Coates, Ralph J.
Eley, J. William
TI The epidemiology of triple-negative breast cancer, including race
SO CANCER CAUSES & CONTROL
LA English
DT Article
DE Breast neoplasms; Molecular epidemiology; Tumor biology; Race
ID ESTROGEN-RECEPTOR; PROGESTERONE-RECEPTOR; AFRICAN-AMERICAN; KI-67
ANTIGEN; MOLECULAR PORTRAITS; PROGNOSTIC MARKERS; RACIAL-DIFFERENCES;
PARAFFIN SECTIONS; HORMONE-RECEPTOR; YOUNGER WOMEN
AB Predictors of intrinsic breast cancer subtypes, including the triple-negative (TN) subtype, are largely unknown. We evaluated whether anthropometrics, demographics, and reproductive history were associated with distinct breast cancer subtypes.
Invasive breast tumors from a population-based case-control study of 476 (116 black and 360 white) Atlanta women aged 20-54, diagnosed between 1990 and 1992, were centrally reviewed and immunohistochemically analyzed for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2); then grouped [TN (ER-PR-HER2-); ER-PR-HER2+; ER/PR+HER2+; ER/PR+HER2- (case-only reference group)]. Data were from interviews and anthropometric measurements; adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression, including both case-only and case-control comparisons.
From the case-only analyses and compared with the ER/PR+HER2- subtype, women with TN tumors were more likely to be obese than normal/underweight [OR = 1.89 (95% CI = 1.22, 2.92)]. Regardless of HER2 status, ER-PR- tumors were associated with black race, young age at first birth, having a recent birth, and being overweight.
Distinct breast cancer subtypes have unique sociodemographic, anthropometric and reproductive characteristics and possibly different pathways for development.
C1 [Trivers, Katrina F.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Lund, Mary Jo; Liff, Jonathan M.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Lund, Mary Jo; Eley, J. William] Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA USA.
[Lund, Mary Jo] Emory Univ, Georgia Canc Ctr Excellence Grady, Atlanta, GA 30322 USA.
[Porter, Peggy L.] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98104 USA.
[Flagg, Elaine W.] Emory Univ, Sch Med, Div Gen Med, Atlanta, GA USA.
[Coates, Ralph J.] Ctr Dis Control & Prevent, Natl Off Publ Hlth Genom, Atlanta, GA 30341 USA.
RP Trivers, KF (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,MS K-55, Atlanta, GA 30341 USA.
EM ktrivers@cdc.gov
FU Intramural CDC HHS [CC999999]; NCI NIH HHS [R01CA71735, R01CA64292]
NR 47
TC 100
Z9 103
U1 1
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-5243
J9 CANCER CAUSE CONTROL
JI Cancer Causes Control
PD SEP
PY 2009
VL 20
IS 7
BP 1071
EP 1082
DI 10.1007/s10552-009-9331-1
PG 12
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA 480ZF
UT WOS:000268775300005
PM 19343511
ER
PT J
AU Dietzen, DJ
Rinaldo, P
Whitley, RJ
Rhead, WJ
Hannon, WH
Garg, UC
Lo, SF
Bennett, MJ
AF Dietzen, Dennis J.
Rinaldo, Piero
Whitley, Ronald J.
Rhead, William J.
Hannon, W. Harry
Garg, Uttam C.
Lo, Stanley F.
Bennett, Michael J.
TI National Academy of Clinical Biochemistry Laboratory Medicine Practice
Guidelines: Follow-Up Testing for Metabolic Disease Identified by
Expanded Newborn Screening Using Tandem Mass Spectrometry; Executive
Summary
SO CLINICAL CHEMISTRY
LA English
DT Article
ID DRIED BLOOD SPOTS; COA DEHYDROGENASE-DEFICIENCY; CONGENITAL
ADRENAL-HYPERPLASIA; ENZYME REPLACEMENT THERAPY; DIRECT MULTIPLEX ASSAY;
ACIDURIA TYPE-I; PROPIONIC ACIDEMIA; GLUTARIC ACIDURIA;
QUANTITATIVE-DETERMINATION; MUCOPOLYSACCHARIDOSIS-I
AB BACKGROUND: Almost all newborns in the US are screened at birth for multiple inborn errors of metabolism using tandem mass spectrometry. Screening tests are designed to be sufficiently sensitive so that cases are not missed. The NACB recognized a need for standard guidelines for laboratory confirmation of a positive newborn screen such that all babies would benefit from equal and optimal follow-up by confirmatory testing.
METHODS: A committee was formed to review available data pertaining to confirmatory testing. The committee evaluated previously published guidelines, published methodological and clinical studies, clinical case reports, and expert opinion to support optimal confirmatory testing. Grading was based on guidelines adopted from criteria derived from the US Preventive Services Task Force and on the strength of recommendations and the quality of the evidence. Three primary methods of analyte measurement were evaluated for confirmatory testing including measurement of amino acids, organic acids, and carnitine esters. The committee graded the evidence for diagnostic utility of each test for the screened conditions.
RESULTS: Ample data and experience were available to make strong recommendations for the practice of analyzing amino acids, organic acids, and acylcarnitines. Likewise, strong recommendations were made for the follow-up test menu for many disorders, particularly those with highest prevalence. Fewer data exist to determine the impact of newborn screening on patient outcomes in all but a few disorders. The guidelines also provide an assessment of developing technology that will fuel a refinement of current practice and ultimate expansion of the diseases detectable by tandem mass spectrometry.
CONCLUSIONS: Guidelines are provided for optimal follow-up testing for positive newborn screens using tandem mass spectrometry. The committee regards these tests as reliable and currently optimal for follow-up testing. (C) 2009 American Association for Clinical Chemistry
C1 [Bennett, Michael J.] Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.
[Dietzen, Dennis J.] Washington Univ, St Louis, MO USA.
[Dietzen, Dennis J.] St Louis Childrens Hosp, St Louis, MO 63178 USA.
[Rinaldo, Piero] Mayo Clin, Coll Med, Rochester, MN USA.
[Whitley, Ronald J.] Univ Kentucky, Med Ctr, Lexington, KY USA.
[Rhead, William J.; Lo, Stanley F.] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
[Rhead, William J.; Lo, Stanley F.] Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA.
[Hannon, W. Harry] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Garg, Uttam C.] Univ Missouri, Kansas City, MO 65211 USA.
[Garg, Uttam C.] Childrens Mercy Hosp, Kansas City, MO 64108 USA.
[Bennett, Michael J.] Univ Penn, Philadelphia, PA 19104 USA.
RP Bennett, MJ (reprint author), Childrens Hosp Philadelphia, Dept Pathol & Lab Med, 34th & Civ Ctr Blvd,5NW58, Philadelphia, PA 19104 USA.
EM bennettmi@email.chop.edu
NR 43
TC 34
Z9 36
U1 1
U2 7
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
EI 1530-8561
J9 CLIN CHEM
JI Clin. Chem.
PD SEP
PY 2009
VL 55
IS 9
BP 1615
EP 1626
DI 10.1373/clinchem.2009.131300
PG 12
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 492DY
UT WOS:000269636000005
PM 19574465
ER
PT J
AU Aberg, JA
Kaplan, JE
Libman, H
Emmanuel, P
Anderson, JR
Stone, VE
Oleske, JM
Currier, JS
Gallant, JE
AF Aberg, Judith A.
Kaplan, Jonathan E.
Libman, Howard
Emmanuel, Patricia
Anderson, Jean R.
Stone, Valerie E.
Oleske, James M.
Currier, Judith S.
Gallant, Joel E.
TI Primary Care Guidelines for the Management of Persons Infected with
Human Immunodeficiency Virus: 2009 Update by the HIV Medicine
Association of the Infectious Diseases Society of America
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID ACTIVE ANTIRETROVIRAL THERAPY; IMMUNIZATION PRACTICES ACIP; PROTEASE
INHIBITOR THERAPY; CHRONIC HEPATITIS-B; UNITED-STATES;
CLINICAL-PRACTICE; DRUG-RESISTANCE; HEALTH-CARE; INTERNATIONAL-PANEL;
ADVISORY-COMMITTEE
AB Evidence-based guidelines for the management of persons infected with human immunodeficiency virus (HIV) were prepared by an expert panel of the HIV Medicine Association of the Infectious Diseases Society of America. These updated guidelines replace those published in 2004. The guidelines are intended for use by health care providers who care for HIV-infected patients or patients who may be at risk for acquiring HIV infection. Since 2004, new antiretroviral drugs and classes have become available, and the prognosis of persons with HIV infection continues to improve. However, with fewer complications and increased survival, HIV-infected persons are increasingly developing common health problems that also affect the general population. Some of these conditions may be related to HIV infection itself and its treatment. HIV-infected persons should be managed and monitored for all relevant age-and gender-specific health problems. New information based on publications from the period 2003-2008 has been incorporated into this document.
C1 [Aberg, Judith A.] NYU, Sch Med, Bellevue Hosp Ctr, AIDS Clin Trials Unit, New York, NY 10016 USA.
[Kaplan, Jonathan E.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Libman, Howard] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA.
[Stone, Valerie E.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA.
[Emmanuel, Patricia] Univ S Florida, Tampa, FL USA.
[Anderson, Jean R.; Gallant, Joel E.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Oleske, James M.] Univ Med & Dent New Jersey, Newark, NJ 07103 USA.
[Currier, Judith S.] Univ Calif Los Angeles, Los Angeles, CA USA.
RP Aberg, JA (reprint author), NYU, Sch Med, Bellevue Hosp Ctr, AIDS Clin Trials Unit, 550 1st Ave,BCD 5,Rm 558, New York, NY 10016 USA.
EM judith.aberg@nyumc.org
RI Oleske, James/C-1951-2016
OI Oleske, James/0000-0003-2305-5605
FU Infectious Diseases Society of America
FX Support for this guideline was provided by the Infectious Diseases
Society of America.
NR 96
TC 197
Z9 204
U1 3
U2 11
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD SEP 1
PY 2009
VL 49
IS 5
BP 651
EP 681
DI 10.1086/605292
PG 31
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 479MA
UT WOS:000268662300001
PM 19640227
ER
PT J
AU Verma, NA
Zheng, XTT
Harris, MU
Cadichon, SB
Melin-Aldana, H
Khetsuriani, N
Oberste, MS
Shulman, ST
AF Verma, Natasha A.
Zheng, Xiaotian T.
Harris, Michelle U.
Cadichon, Sandra B.
Melin-Aldana, Hector
Khetsuriani, Nino
Oberste, M. Steven
Shulman, Stanford T.
TI Outbreak of Life-Threatening Coxsackievirus B1 Myocarditis in Neonates
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID INFECTION; DISEASE; VIRUS; AGE
AB In the summer and fall of 2007, we observed a unique cluster of cases of severe coxsackievirus B1 (CVB1) infection among Chicago area neonates. Eight neonates had closely related strains of CVB1 that were typed at the Centers of Disease Control and Prevention; 2 other neonates had CVB infections, 1 of which was further identified as serotype CVB1. All had severe myocarditis; 1 neonate underwent heart transplantation, and 1 died of severe left ventricular dysfunction.
C1 [Verma, Natasha A.; Harris, Michelle U.; Shulman, Stanford T.] Childrens Mem Hosp, Div Infect Dis, Dept Pediat, Chicago, IL 60614 USA.
[Cadichon, Sandra B.] Childrens Mem Hosp, Div Neonatol, Dept Pediat, Chicago, IL 60614 USA.
[Zheng, Xiaotian T.; Melin-Aldana, Hector] Childrens Mem Hosp, Dept Pathol, Chicago, IL 60614 USA.
[Verma, Natasha A.; Zheng, Xiaotian T.; Cadichon, Sandra B.; Melin-Aldana, Hector; Shulman, Stanford T.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
[Khetsuriani, Nino; Oberste, M. Steven] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
RP Verma, NA (reprint author), Childrens Hosp Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027 USA.
EM nverma@chla.usc.edu
NR 21
TC 20
Z9 23
U1 0
U2 0
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD SEP 1
PY 2009
VL 49
IS 5
BP 759
EP 763
DI 10.1086/605089
PG 5
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 479MA
UT WOS:000268662300015
PM 19622042
ER
PT J
AU Bern, C
Montgomery, SP
AF Bern, Caryn
Montgomery, Susan P.
TI An Estimate of the Burden of Chagas Disease in the United States
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID TRYPANOSOMA-CRUZI; EPIDEMIOLOGY; IMPACT; TEXAS
AB Chagas disease causes the highest burden of any parasitic disease in the Western hemisphere. By applying published seroprevalence figures to immigrant populations, we estimate that 300,167 individuals with Trypanosoma cruzi infection live in the United States, with 30,000-45,000 cardiomyopathy cases and 63-315 congenital infections annually. T. cruzi causes a substantial disease burden in the United States.
C1 [Bern, Caryn; Montgomery, Susan P.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30341 USA.
RP Bern, C (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, MS F-22,4770 Buford Highway NE, Atlanta, GA 30341 USA.
EM CBern@cdc.gov
NR 18
TC 211
Z9 217
U1 2
U2 13
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD SEP 1
PY 2009
VL 49
IS 5
BP E52
EP E54
DI 10.1086/605091
PG 3
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 479MA
UT WOS:000268662300031
PM 19640226
ER
PT J
AU Wikswo, ME
Khetsuriani, N
Fowlkes, AL
Zheng, XT
Penaranda, S
Verma, N
Shulman, ST
Sircar, K
Robinson, CC
Schmidt, T
Schnurr, D
Oberste, MS
AF Wikswo, Mary E.
Khetsuriani, Nino
Fowlkes, Ashley L.
Zheng, Xiaotian
Penaranda, Silvia
Verma, Natasha
Shulman, Stanford T.
Sircar, Kanta
Robinson, Christine C.
Schmidt, Terry
Schnurr, David
Oberste, M. Steven
TI Increased Activity of Coxsackievirus B1 Strains Associated with Severe
Disease among Young Infants in the United States, 2007-2008
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID NEONATAL ENTEROVIRUS INFECTIONS; CARE BABY UNIT; PERINATAL ECHOVIRUS;
VIRUS INFECTIONS; RISK-FACTORS; PLECONARIL; NURSERY; IMMUNOGLOBULIN;
EPIDEMIOLOGY; SEQUENCES
AB Background. Enterovirus infections are very common and typically cause mild illness, although neonates are at higher risk for severe illness. In 2007, the Centers for Disease Control and Prevention (CDC) received multiple reports of severe neonatal illness and death associated with coxsackievirus B1 (CVB1), a less common enterovirus serotype not previously associated with death in surveillance reports to the CDC.
Methods. This report includes clinical, epidemiologic, and virologic data from cases of severe neonatal illness associated with CVB1 reported during the period from 2007 through 2008 to the National Enterovirus Surveillance System (NESS), a voluntary, passive surveillance system. Also included are data on additional cases reported to the CDC outside of the NESS. Virus isolates or original specimens obtained from patients from 25 states were referred to the CDC picornavirus laboratory for molecular typing or characterization.
Results. During 2007-2008, the NESS received 1079 reports of enterovirus infection. CVB1 accounted for 176 (23%) of 775 reported cases with known serotype, making it the most commonly reported serotype for the first time ever in the NESS. Six neonatal deaths due to CVB1 infection were also reported to the CDC during that time. Phylogenetic analysis of the 2007 and 2008 CVB1 strains indicated that the increase in cases resulted from widespread circulation of a single genetic lineage that had been present in the United States since at least 2001.
Conclusions. Healthcare providers and public health departments should be vigilant to the possibility of continuing CVB1-associated neonatal illness, and testing and continued reporting of enterovirus infections should be encouraged.
C1 [Wikswo, Mary E.; Khetsuriani, Nino; Fowlkes, Ashley L.; Penaranda, Silvia; Oberste, M. Steven] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Sircar, Kanta] Ctr Dis Control & Prevent, Epidemiol Intelligence Serv, Atlanta, GA 30333 USA.
[Zheng, Xiaotian] Childrens Mem Hosp, Dept Pathol & Lab Med, Chicago, IL 60614 USA.
[Verma, Natasha; Shulman, Stanford T.] Childrens Mem Hosp, Dept Pediat, Chicago, IL 60614 USA.
[Zheng, Xiaotian; Verma, Natasha; Shulman, Stanford T.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
[Sircar, Kanta] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA.
[Schnurr, David] Calif Dept Publ Hlth, Richmond, CA USA.
[Robinson, Christine C.] Childrens Hosp, Dept Pathol & Lab Med, Aurora, CO USA.
[Schmidt, Terry] Alaska State Publ Hlth Virol Lab, Fairbanks, AK USA.
RP Wikswo, ME (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,Mailstop A-34, Atlanta, GA 30333 USA.
EM mwikswo@cdc.gov
FU CDC
FX CDC.
NR 38
TC 29
Z9 33
U1 0
U2 2
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD SEP 1
PY 2009
VL 49
IS 5
BP E44
EP E51
DI 10.1086/605090
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 479MA
UT WOS:000268662300030
PM 19622041
ER
PT J
AU Patel, A
Gorman, SE
AF Patel, A.
Gorman, S. E.
TI Stockpiling Antiviral Drugs for the Next Influenza Pandemic
SO CLINICAL PHARMACOLOGY & THERAPEUTICS
LA English
DT Editorial Material
AB The threat of an influenza pandemic has been at the forefront of public health preparedness for more than 5 years. The national planning effort has included stockpiling antiviral drugs in the Centers for Disease Control and prevention's strategic national stockpile (SNS). This article highlights the composition of the SNS before the 2009 H1N1 pandemic and includes considerations for future antiviral stockpile purchases, focusing on emergence of oseltamivir resistance and the need for additional pediatric supplies.
C1 [Patel, A.; Gorman, S. E.] Ctr Dis Control & Prevent, Div Strateg Natl Stockpile, Atlanta, GA 30333 USA.
RP Patel, A (reprint author), Ctr Dis Control & Prevent, Div Strateg Natl Stockpile, Atlanta, GA 30333 USA.
EM Apatel7@cdc.gov
NR 5
TC 20
Z9 21
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0009-9236
J9 CLIN PHARMACOL THER
JI Clin. Pharmacol. Ther.
PD SEP
PY 2009
VL 86
IS 3
BP 241
EP 243
DI 10.1038/clpt.2009.142
PG 4
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 491AL
UT WOS:000269549100010
PM 19707215
ER
PT J
AU Kourtis, AP
Bansil, P
Kahn, HS
Posner, SF
Jamieson, DJ
AF Kourtis, Athena P.
Bansil, Pooja
Kahn, Henry S.
Posner, Samuel F.
Jamieson, Denise J.
TI Diabetes Trends in Hospitalized HIV-Infected Persons in the United
States, 1994-2004
SO CURRENT HIV RESEARCH
LA English
DT Article
DE Diabetes; HIV infection; Hospitalizations; United States; Trends
ID ANTIRETROVIRAL THERAPY; YOUNG-ADULTS; RISK-FACTORS; MELLITUS;
ADOLESCENTS; PREVALENCE; CHILDREN; BURDEN; US
AB The prevalence of diabetes in the United States is rising. As HIV-infected people live longer, they become more susceptible to chronic diseases such as diabetes. Additionally, some antiretroviral agents have been linked to impaired glucose tolerance and increased diabetes risk. To estimate the burden and trends of diabetes among hospitalized HIV-infected persons in the United States, we used data from the 1994-2004 Nationwide Inpatient Sample, a nationally representative survey of inpatient hospitalizations. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for demographic and hospital characteristics using logistic regression. Between 1994 and 2004, the rate of hospitalizations with a diabetes code per 100 hospitalizations increased from 3.9 to 8.4 (2.2 fold) among HIV-infected persons. Among HIV-uninfected people, the corresponding rate increased from 12.8 to 17.7 (1.4 fold). Since 1998, the mean age of HIV-infected hospitalized people with a diabetes diagnosis rose from 45 to 66 years and became similar to that of HIV-uninfected people. Compared to 1994-1996, in 2002-2004 the probability of hospitalizations with diabetes increased among both HIV-infected and HIV-uninfected persons (OR, 1.92, 95% CI, 1.79-2.05 and OR, 1.38, 95% CI, 1.36-1.40, respectively). Given the increasing prevalence of diabetes in hospitalized HIV-infected persons, it will be important to monitor the trends closely in addition to the effects of different types of antiretroviral regimens, in order to optimize comprehensive long-term care of HIV-infected persons.
C1 [Kourtis, Athena P.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
CONRAD, Atlanta, GA USA.
RP Kourtis, AP (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, MS-K34,2900 Woodcock Blvd, Atlanta, GA 30341 USA.
EM apk3@cdc.gov
OI Kahn, Henry/0000-0003-2533-1562; Posner, Samuel/0000-0003-1574-585X
NR 29
TC 3
Z9 3
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
EMIRATES
SN 1570-162X
J9 CURR HIV RES
JI Curr. HIV Res.
PD SEP
PY 2009
VL 7
IS 5
BP 481
EP 486
PG 6
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 514GG
UT WOS:000271381800004
PM 19925399
ER
PT J
AU Lawrence, JM
Anderson, A
Imperatore, G
Mayer-Davis, EJ
Seid, M
Waitzfelder, B
Yi-Frazier, J
AF Lawrence, J. M.
Anderson, A.
Imperatore, G.
Mayer-Davis, E. J.
Seid, M.
Waitzfelder, B.
Yi-Frazier, J.
TI Diabetes-related quality of life and glycaemic control among youth with
type 1 diabetes
SO DIABETOLOGIA
LA English
DT Meeting Abstract
CT 45th Annual Meeting of the
European-Association-for-the-Study-of-Diabetes
CY SEP 30-OCT 02, 2009
CL Vienna, AUSTRIA
SP European Assoc Study Diabet
C1 [Lawrence, J. M.] Kaiser Permanente, Pasadena, CA USA.
[Anderson, A.] Wake Forest Univ, Winston Salem, NC 27109 USA.
[Imperatore, G.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Mayer-Davis, E. J.] Univ N Carolina, Chapel Hill, NC USA.
[Seid, M.] Cincinnati Childrens Hosp & Med Ctr, Cincinnati, OH USA.
[Waitzfelder, B.] Pacific Hlth Res Inst, Honolulu, HI USA.
[Yi-Frazier, J.] Seattle Childrens Hosp, Seattle, WA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
J9 DIABETOLOGIA
JI Diabetologia
PD SEP
PY 2009
VL 52
MA 53
BP S28
EP S29
PG 2
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 487HK
UT WOS:000269262400054
ER
PT J
AU Cheng, CKY
Cowling, BJ
Chan, KH
Fang, VJ
Seto, WH
Yung, R
Uyeki, TM
Houck, PM
Peiris, JSM
Leung, GM
AF Cheng, Calvin K. Y.
Cowling, Benjamin J.
Chan, Kwok Hung
Fang, Vicky J.
Seto, Wing Hong
Yung, Raymond
Uyeki, Timothy M.
Houck, Peter M.
Peiris, J. S. Malik
Leung, Gabriel M.
TI Factors affecting QuickVue Influenza A plus B rapid test performance in
the community setting
SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
LA English
DT Article
DE Human influenza; Immunoassay; Diagnostic tests; Sensitivity;
Specificity; Viral load
ID REVERSE TRANSCRIPTION-PCR; POLYMERASE-CHAIN-REACTION; VIRAL CULTURE;
RESPIRATORY VIRUSES; ANTIVIRAL TREATMENT; CHILDREN; DIAGNOSIS; ACCURACY;
IMMUNOASSAY; INFECTIONS
AB Rapid diagnosis of influenza can facilitate timely clinical management. We evaluated the performance of the QuickVue Influenza A + B test (Quidel, San Diego, CA) in a community setting and investigated the factors affecting test sensitivity. We recruited 1008 subjects from 30 outpatient clinics in Hong Kong between February and September 2007. Each subject provided 2 pooled pairs of nose and throat swabs; 1 pair was tested by the QuickVue rapid test on site, and the other pair was sent to a laboratory for reference tests. Among 998 enrolled subjects with valid results, the rapid test had overall sensitivity of 0.68 and specificity of 0.96 compared with viral culture. Sensitivity for both influenza A and B was significantly higher for specimens with viral loads greater than 5 log(10) copies/mL. The QuickVue Influenza A + B test has similar sensitivity in point-of-care community settings to more controlled conditions. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Cheng, Calvin K. Y.; Cowling, Benjamin J.; Fang, Vicky J.; Leung, Gabriel M.] Univ Hong Kong, Dept Community Med, Hong Kong, Hong Kong, Peoples R China.
[Cheng, Calvin K. Y.; Cowling, Benjamin J.; Fang, Vicky J.; Leung, Gabriel M.] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China.
[Chan, Kwok Hung; Peiris, J. S. Malik] Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China.
[Seto, Wing Hong] Hosp Author, Queen Mary Hosp, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China.
[Yung, Raymond] Govt Hong Kong SAR, Dept Hlth, Ctr Hlth Protect, Hong Kong, Hong Kong, Peoples R China.
[Uyeki, Timothy M.] Ctr Dis Control & Prevent, Influenza Div, NCPDCID, Atlanta, GA 30333 USA.
[Houck, Peter M.] CDC, Seattle Quarantine Stn, Div Global Migrat & Quarantine, NCPDCID, Seattle, WA 98158 USA.
RP Cowling, BJ (reprint author), Univ Hong Kong, Dept Community Med, 21 Sassoon Rd, Hong Kong, Hong Kong, Peoples R China.
EM bcowling@hku.hk
RI Cowling, Benjamin/C-4263-2009
OI Cowling, Benjamin/0000-0002-6297-7154
FU US Centers for Disease Control and Prevention [1 U01 C1000439-01];
Research Fund for the Control of Infectious Disease; Food and Health
Bureau, Government of the Hong Kong [HKU-AA-22]; Area of Excellence
Scheme of the Hong Kong University [AoE/M-12/06]
FX This work has received financial support from the US Centers for Disease
Control and Prevention (grant no. 1 U01 C1000439-01), the Research Fund
for the Control of Infectious Disease, Food and Health Bureau,
Government of the Hong Kong SAR (grant no. HKU-AA-22), and the Area of
Excellence Scheme of the Hong Kong University Grants Committee (grant
no. AoE/M-12/06).
NR 29
TC 31
Z9 31
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0732-8893
J9 DIAGN MICR INFEC DIS
JI Diagn. Microbiol. Infect. Dis.
PD SEP
PY 2009
VL 65
IS 1
BP 35
EP 41
DI 10.1016/j.diagmicrobio.2009.05.003
PG 7
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA 487AT
UT WOS:000269243400006
PM 19679233
ER
PT J
AU Rondinelli, AJ
Ouellet, LJ
Strathdee, SA
Latka, MH
Hudson, SM
Hagan, H
Garfein, RS
AF Rondinelli, Amanda J.
Ouellet, Lawrence J.
Strathdee, Steffanie A.
Latka, Mary H.
Hudson, Sharon M.
Hagan, Holly
Garfein, Richard S.
TI Young adult injection drug users in the United States continue to
practice HIV risk behaviors
SO DRUG AND ALCOHOL DEPENDENCE
LA English
DT Article
DE Young injection drug users; HIV; Risk behaviors; Methamphetamine
ID HUMAN-IMMUNODEFICIENCY-VIRUS; NEW-YORK-CITY; US METROPOLITAN-AREAS;
SEXUAL RISK; METHAMPHETAMINE USE; SAN-FRANCISCO; SMOKE CRACK; INFECTION;
MEN; ASSOCIATION
AB Background: Injection drug users (IDUs) are at risk of acquiring HIV through injection and sexual practices.
Methods: We analyzed data collected in five U.S. cities between 2002 and 2004 to identify correlates of HIV infection among 3285 IDUs ages 15-30 years.
Results: Overall, HIV prevalence was 2.8% (95% CI 2.3-3.4), ranging from 0.8% in Chicago to 6.3% in Los Angeles. Mean age was 24 years, 70% were male, 64% non-Hispanic (NH) white, 7% NH black, 17% Hispanic, and 12% were other/mixed race. HIV infection was independently associated with: race/ethnicity (NH black [AOR 4.1,95% CI 1.9-9.1], Hispanic [AOR 3.6,95% CI 1.5-8.4], or other/mixed [AOR 2.3,95% CI 1.1-5.2] vs. NH white); males who only had sex with males compared to males who only had sex with females (AOR 15.3, 95% CI 6.8-34.5); injecting methamphetamine alone or with heroin compared to heroin only (AOR 4.0, 95% CI 1.7-9.7); reporting inconsistent means of obtaining income compared to regular jobs (AOR 2.3, 95% CI 1.1-4.8); and having a history of exchanging sex for money/drugs (AOR 2.8, 95% CI 1.5-5.2).
Conclusions: More than two decades after injection and sexual practices were identified as risk factors for HIV infection, these behaviors remain common among young IDUs. While racial/ethnic disparities persist, methamphetamine may be replacing cocaine as the drug most associated with HIV seropositivity. HIV prevention interventions targeting young IDUs and address both sexual and injection practices are needed. Published by Elsevier Ireland Ltd.
C1 [Garfein, Richard S.] Univ Calif San Diego, Div Global Publ Hlth, Dept Med, Sch Med, San Diego, CA 92093 USA.
[Rondinelli, Amanda J.] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA.
[Ouellet, Lawrence J.] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat MC 923, Chicago, IL 60612 USA.
[Latka, Mary H.] Aurum Inst Hlth Res, Johannesburg, Gauteng, South Africa.
[Hudson, Sharon M.] Hlth Res Assoc, Hollywood, CA 90038 USA.
[Hagan, Holly] Natl Dev & Res Inst, New York, NY 10010 USA.
[Garfein, Richard S.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA.
RP Garfein, RS (reprint author), Univ Calif San Diego, Div Global Publ Hlth, Dept Med, Sch Med, 9500 Gilman Dr,Mailstop 0507, San Diego, CA 92093 USA.
EM rgarfein@ucsd.edu
FU PHS HHS [U64/CCU017615, U64/CCU517656, 64/CCU217659, U64/CCU317662,
U64/CCU917655]
NR 32
TC 30
Z9 32
U1 1
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0376-8716
J9 DRUG ALCOHOL DEPEN
JI Drug Alcohol Depend.
PD SEP 1
PY 2009
VL 104
IS 1-2
BP 167
EP 174
DI 10.1016/j.drugalcdep.2009.05.013
PG 8
WC Substance Abuse; Psychiatry
SC Substance Abuse; Psychiatry
GA 478TK
UT WOS:000268611000023
PM 19559543
ER
PT J
AU Mehla, R
Kumar, SRP
Yadav, P
Barde, PV
Yergolkar, PN
Erickson, BR
Carroll, SA
Mishra, AC
Nichol, ST
Mourya, DT
AF Mehla, Rajeev
Kumar, Sandeep R. P.
Yadav, Pragya
Barde, Pradip V.
Yergolkar, Prasanna N.
Erickson, Bobbie R.
Carroll, Serena A.
Mishra, Akhilesh C.
Nichol, Stuart T.
Mourya, Devendra T.
TI Recent Ancestry of Kyasanur Forest Disease Virus
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID HEMORRHAGIC-FEVER VIRUS; SAUDI-ARABIA; MOLECULAR PHYLOGENIES; SEQUENCE
ALIGNMENT; FLAVIVIRUSES; TICK; EVOLUTION
AB Kyasanur Forest disease virus (KFDV) is enzootic to India and maintained in ticks, mammals, and birds. It causes severe febrile illness in humans and was first recognized in 1957 associated with a high number of deaths among monkeys in Kyasanur Forest. Genetic analysis of 48 viruses isolated in India during 1957-2006 showed low diversity (1.2%). Bayesian coalescence analysis of these sequences and those of KFDVs from Saudi Arabia and the People's Republic of China estimated that KFDVs have evolved at a mean rate of approximate to 6.4 x 10(-4) substitutions/site/year, which is similar to rates estimated for mosquito-borne flaviviruses. KFDVs were estimated to have shared a common ancestor in approximate to 1942, fifteen years before identification of the disease in India. These data are consistent with the view that KFD represented a newly emerged disease when first recognized. Recent common ancestry of KFDVs from India and Saudi Arabia, despite their large geographic separation, indicates long-range movement of virus, possibly by birds.
C1 [Mehla, Rajeev; Kumar, Sandeep R. P.; Yadav, Pragya; Barde, Pradip V.; Yergolkar, Prasanna N.; Mishra, Akhilesh C.; Mourya, Devendra T.] Natl Inst Virol, Pune 411021, Maharashtra, India.
[Erickson, Bobbie R.; Carroll, Serena A.; Nichol, Stuart T.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Mourya, DT (reprint author), Natl Inst Virol, Microbial Containment Complex,Sus Rd, Pune 411021, Maharashtra, India.
EM mouryadt@icmr.org.in
FU Council of Scientific and Industrial Research, India
FX We thank the staff at the virus repository, National Institute of
Virology, Pune, India, for providing Iyophilized virus stocks; the staff
of the Virus Diagnostic Laboratory, Shimoga, India, for providing serum
samples; the Council of Scientific and Industrial Research, India, for a
senior research fellowship; and Craig Manning for creating the map.
NR 34
TC 34
Z9 35
U1 0
U2 4
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD SEP
PY 2009
VL 15
IS 9
BP 1431
EP 1437
DI 10.3201/eid1509.080759
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 490NK
UT WOS:000269507500013
PM 19788811
ER
PT J
AU Klevens, RM
Miller, J
Vonderwahl, C
Speers, S
Alelis, K
Sweet, K
Rocchio, E
Poissant, T
Vogt, TM
Gallagher, K
AF Klevens, R. Monina
Miller, Jeremy
Vonderwahl, Candace
Speers, Suzanne
Alelis, Karen
Sweet, Kristin
Rocchio, Elena
Poissant, Tasha
Vogt, Tara M.
Gallagher, Kathleen
TI Population-based Surveillance for Hepatitis C Virus, United States,
2006-2007
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID MANAGEMENT; INFECTION
AB Surveillance for hepatitis C virus infection in 6 US sites identified 20,285 newly reported cases in 12 months (report rate 69 cases/100,000 population, range 25-108/100,000). Staff reviewed 4 laboratory reports per new case. Local surveillance data can document the effects of disease, support linkage to care, and help prevent secondary transmission.
C1 [Klevens, R. Monina; Miller, Jeremy; Vogt, Tara M.; Gallagher, Kathleen] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA.
[Vonderwahl, Candace] Colorado Dept Hlth, Denver, CO 80220 USA.
[Speers, Suzanne] Connecticut Dept Publ Hlth, Hartford, CT USA.
[Alelis, Karen] Florida Hlth Dept Pinellas Cty, St Petersburg, FL USA.
[Sweet, Kristin] Minnesota Dept Hlth, St Paul, MN USA.
[Rocchio, Elena] New York State Dept Hlth, Albany, NY USA.
[Poissant, Tasha] Oregon Publ Hlth Div, Portland, OR USA.
RP Klevens, RM (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G37, Atlanta, GA 30329 USA.
EM rmk2@cdc.gov
OI Poissant, Tasha/0000-0003-4407-272X
NR 13
TC 21
Z9 22
U1 0
U2 0
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD SEP
PY 2009
VL 15
IS 9
BP 1499
EP 1502
DI 10.3201/eid1509.081050
PG 4
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 490NK
UT WOS:000269507500028
PM 19788825
ER
PT J
AU Schultz, MG
Morens, DM
AF Schultz, Myron G.
Morens, David M.
TI Charles-Jules-Henri Nicolle
SO EMERGING INFECTIOUS DISEASES
LA English
DT Biographical-Item
C1 [Schultz, Myron G.] Ctr Dis Control & Prevent, Atlanta, GA 30303 USA.
[Morens, David M.] NIH, Bethesda, MD 20892 USA.
RP Schultz, MG (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE, Atlanta, GA 30303 USA.
EM mgs1@cdc.gov
NR 1
TC 0
Z9 0
U1 0
U2 1
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD SEP
PY 2009
VL 15
IS 9
BP 1520
EP 1522
DI 10.3201/eid1509.090891
PG 3
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 490NK
UT WOS:000269507500034
ER
PT J
AU Aguilar, PV
Camargo, W
Vargas, J
Guevara, C
Roca, Y
Felices, V
Laguna-Torres, VA
Tesh, R
Ksiazek, TG
Kochel, TJ
AF Aguilar, Patricia V.
Camargo, Wilfredo
Vargas, Jorge
Guevara, Carolina
Roca, Yelin
Felices, Vidal
Alberto Laguna-Torres, V.
Tesh, Robert
Ksiazek, Thomas G.
Kochel, Tadeusz J.
TI Reemergence of Bolivian Hemorrhagic Fever, 2007-2008
SO EMERGING INFECTIOUS DISEASES
LA English
DT Letter
ID GENETIC DIVERSITY; VIRUS
C1 [Aguilar, Patricia V.; Guevara, Carolina; Felices, Vidal; Alberto Laguna-Torres, V.; Kochel, Tadeusz J.] USN, Med Res Ctr Detachment, Lima, Peru.
[Vargas, Jorge; Roca, Yelin] Ctr Nacl Enfermedades Trop, Santa Cruz, Bolivia.
[Camargo, Wilfredo] El Serv Dept Salud, Beni, Bolivia.
[Tesh, Robert] Univ Texas Med Branch, Galveston, TX USA.
[Ksiazek, Thomas G.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Aguilar, PV (reprint author), USN, Med Res Ctr Detachment, 3230 Lima Pl, Washington, DC 20521 USA.
EM patricia.aguilar@med.navy.mil
RI Valle, Ruben/A-7512-2013
NR 8
TC 17
Z9 17
U1 0
U2 3
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD SEP
PY 2009
VL 15
IS 9
BP 1526
EP 1528
DI 10.3201/eid1509.090017
PG 3
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 490NK
UT WOS:000269507500037
PM 19788833
ER
PT J
AU Potter, P
AF Potter, Polyxeni
TI Never Has There Been a Shade
SO EMERGING INFECTIOUS DISEASES
LA English
DT Editorial Material
C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Potter, P (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D61, Atlanta, GA 30333 USA.
EM PMP1@cdc.gov
NR 6
TC 0
Z9 0
U1 0
U2 0
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD SEP
PY 2009
VL 15
IS 9
BP 1541
EP 1542
DI 10.3201/eid1509.000000
PG 2
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 490NK
UT WOS:000269507500044
ER
PT J
AU Carwile, JL
Luu, HT
Bassett, LS
Driscoll, DA
Yuan, C
Chang, JY
Ye, XY
Calafat, AM
Michels, KB
AF Carwile, Jenny L.
Luu, Henry T.
Bassett, Laura S.
Driscoll, Daniel A.
Yuan, Caterina
Chang, Jennifer Y.
Ye, Xiaoyun
Calafat, Antonia M.
Michels, Karin B.
TI Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE biomarkers; bisphenol A; endocrine disruptors; human; polycarbonate
plastic
ID ESTROGENIC CHEMICALS; EXPOSURE; POPULATION; XENOESTROGENS; RECEPTOR
AB BACKGROUND: Bisphenol A (BPA) is a high-production-volume chemical commonly used in the manufacture of polycarbonate plastic. Low-level concentrations of BPA in animals and possibly in humans may cause endocrine disruption. Whether ingestion of food or beverages from polycarbonate containers increases BPA concentrations in humans has not been studied.
OBJECTIVES: We examined the association between use of polycarbonate beverage containers and urinary BPA concentrations in humans.
METHODS: We conducted a nonrandomized intervention of 77 Harvard College students to compare urinary BPA concentrations collected after a washout phase of I week to those taken after an intervention week during which most cold beverages were consumed from polycarbonate drinking bottles. Paired t-tests were used to assess the difference in urinary BPA concentrations before and after polycarbonate bottle use.
RESULTS: The geometric mean urinary BPA concentration at the end of the washout phase was 1.2 mu g/g creatinine, increasing to 2.0 mu g/g creatinine after 1 week of polycarbonate bottle use. Urinary BPA concentrations increased by 69% after use of polycarbonate bottles (p < 0.0001). The association was stronger among participants who reported 90% compliance (77% increase; p < 0.0001) than among those reporting < 90% compliance (55% increase; p = 0.03), but this difference was not statistically significant (p = 0.54).
CONCLUSIONS: One week of polycarbonate bottle use increased urinary BPA concentrations by two-thirds. Regular consumption of cold beverages from polycarbonate bottles is associated with a substantial increase in urinary BPA concentrations irrespective of exposure to BPA from other sources.
C1 [Michels, Karin B.] Harvard Univ, Dept Obstet Gynecol & Reprod Biol, Brigham & Womens Hosp, Sch Med,Obstet & Gynecol Epidemiol Ctr, Boston, MA 02116 USA.
[Carwile, Jenny L.; Michels, Karin B.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Cambridge, MA 02138 USA.
[Luu, Henry T.; Bassett, Laura S.; Driscoll, Daniel A.; Yuan, Caterina; Chang, Jennifer Y.] Harvard Univ, Fac Arts & Sci, Harvard Coll, Cambridge, MA 02138 USA.
[Ye, Xiaoyun; Calafat, Antonia M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA USA.
RP Michels, KB (reprint author), Harvard Univ, Dept Obstet Gynecol & Reprod Biol, Brigham & Womens Hosp, Sch Med,Obstet & Gynecol Epidemiol Ctr, 221 Longwood Ave, Boston, MA 02116 USA.
EM kmichels@rics.bwh.harvard.edu
OI Driscoll, Daniel/0000-0003-4449-8990
FU Harvard University Center for the Environment; National Institute of
Environmental Health Sciences Biological Analysis Core; Department of
Environmental Health; Harvard School of Public Health; Training Program
in Environmental Epidemiology [T32 ES07069]
FX This project was supported by a Harvard University Center for the
Environment faculty research grant to K.B.M. and by funds from the
National Institute of Environmental Health Sciences Biological Analysis
Core, Department of Environmental Health, Harvard School of Public
Health to K.B.M. J.L.C. was supported by the Training Program in
Environmental Epidemiology under grant T32 ES07069.
NR 35
TC 92
Z9 97
U1 1
U2 24
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD SEP
PY 2009
VL 117
IS 9
BP 1368
EP 1372
DI 10.1289/ehp.0900604
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 490EE
UT WOS:000269479900023
PM 19750099
ER
PT J
AU Toms, LML
Sjodin, A
Harden, F
Hobson, P
Jones, R
Edenfield, E
Mueller, JF
AF Toms, Leisa-Maree L.
Sjoedin, Andreas
Harden, Fiona
Hobson, Peter
Jones, Richard
Edenfield, Emily
Mueller, Jochen F.
TI Serum Polybrominated Diphenyl Ether (PBDE) Levels Are Higher in Children
(2-5 Years of Age) than in Infants and Adults
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE Australia; children; cord blood; human blood serum; PBDEs;
polybrominated diphenyl ethers
ID POLYCHLORINATED-BIPHENYLS; BREAST-MILK; FLAME RETARDANTS; TEMPORAL
TRENDS; HUMAN EXPOSURE; UNITED-STATES; FETAL BLOOD; HOUSE-DUST;
POPULATION; CONTAMINANTS
AB BACKGROUND: Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in many products and have been detected in human samples worldwide. Limited data show that concentrations are elevated in young children.
OBJECTIVES: We investigated the association between PBDEs and age with an emphasis on young children from Australia in 2005-2007.
METHODS: We collected human blood serum samples (n = 2,420), which we stratified by age and sex and pooled for analysis of PBDEs.
RESULTS: The sum of BDE-47, -99, -100, and -153 concentrations (Sigma(4)PBDE) increased from 0-0.5 years (mean +/- SD, 14 +/- 3.4 ng/g lipid) to peak at 2.6-3 years (51 +/- 36 ng/g lipid; p < 0.001) and then decreased until 31-45 years (9.9 +/- 1.6 ng/g lipid). We observed no further significant decrease among ages 31-45, 45-60 (p = 0.964), or > 60 years (p = 0.894). The mean Sigma(4)PBDE concentration in cord blood (24 +/- 14 ng/g lipid) did not differ significantly from that in adult serum at ages 15-30 (p = 0.198) or 31-45 years (p = 0.140). We found no temporal trend when we compared the present results with Australian PBDE data from 2002-2005. PBDE concentrations were higher in males than in females; however, this difference reached statistical significance only for BDE-153 (P = 0.05).
CONCLUSIONS: The observed peak concentration at 2.6-3 years of age is later than the period when breast-feeding is typically ceased. This suggests that in addition to the exposure via human milk, young children have higher exposure to these chemicals and/or a lower capacity to eliminate them.
C1 [Toms, Leisa-Maree L.; Mueller, Jochen F.] Univ Queensland, Natl Res Ctr Environm Toxicol, Coopers Plains, Qld 4108, Australia.
[Sjoedin, Andreas; Jones, Richard; Edenfield, Emily] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Harden, Fiona] Queensland Univ Technol, Sch Life Sci, Gardens Point, Qld, Australia.
[Hobson, Peter] Sullivan Nicolaides Pathol, Taringa, Qld, Australia.
RP Toms, LML (reprint author), Univ Queensland, Natl Res Ctr Environm Toxicol, 39 Kessels Rd, Coopers Plains, Qld 4108, Australia.
EM l.toms@uq.edu.au
RI Mueller, Jochen/C-6241-2008; Toms, Leisa-Maree/C-9530-2009; Sjodin,
Andreas/F-2464-2010; Harden, Fiona/C-2450-2011;
OI Toms, Leisa-Maree/0000-0002-1444-1638; Harden,
Fiona/0000-0003-4831-2292; Mueller, Jochen/0000-0002-0000-1973
NR 57
TC 92
Z9 95
U1 0
U2 25
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD SEP
PY 2009
VL 117
IS 9
BP 1461
EP 1465
DI 10.1289/ehp.0900596
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 490EE
UT WOS:000269479900038
PM 19750114
ER
PT J
AU McGlynn, KA
Guo, XG
Graubard, BI
Brock, JW
Klebanoff, MA
Longnecker, MP
AF McGlynn, Katherine A.
Guo, Xuguang
Graubard, Barry I.
Brock, John W.
Klebanoff, Mark A.
Longnecker, Matthew P.
TI Maternal Pregnancy Levels of Polychlorinated Biphenyls and Risk of
Hypospadias and Cryptorchidism in Male Offspring
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE cryptorchidism; hypospadias; polychlorinated biphenyls; testicular
dysgenesis syndrome
ID MALE REPRODUCTIVE FUNCTION; HUMAN SEMEN QUALITY; DIOXIN-LIKE PCBS;
ORGANOCHLORINE CONTAMINANTS; PRENATAL EXPOSURE; HUMAN-MILK;
DIBENZOFURANS; POPULATION; FERTILITY; CONGENERS
AB BACKGROUND: The etiologies of the male urogenital anomalies cryptorchidism and hypospadias are poorly understood. It has been suggested, however, that in utero hormone levels may be related to risk. Endocrine-disrupting chemicals, including polychlorinated biphenyl (PCB) compounds, may alter hormone levels and thereby affect the fetus.
OBJECTIVES: To examine whether in utero PCB exposure is related to cryptorchidism and hypospadias, we examined PCB levels among pregnant women enrolled in the Collaborative Perinatal Project (CPP).
METHODS: The CPP enrolled pregnant women at 12 U.S. medical centers between 1959 and 1965. For the present research, we analyzed third-trimester serum samples from the mothers of 230 sons with cryptorchidism, 201 sons with hypospadias, and 593 sons with neither condition. We estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression and examined the associations of each anomaly with individual PCB congener levels, sum of PCBs, and several functional groupings of PCBs.
RESULTS: In general, the ORs for cryptorchidism or hypospadias showed no notable associations with individual PCB congener levels or functional groupings of PCBs. However, the ORs and 95% CIs for the sum of PCBs associated with hypospadias were as follows: 0-1.9 mu g/L, reference group; 2-2.9 mu g/L, OR = 1.57, 95% Cl, 1.05-2.34; 3-3.9 mu g/L, OR = 1.45, 95% Cl, 0.90-2.34; and >= 4.0 mu g/L, OR = 1.69, 95% Cl, 1.06-2.68; p-value for trend = 0.08.
CONCLUSIONS: Given the large number of associations examined, these findings do not strongly support the hypothesis that PCBs are associated with cryptorchidism or hypospadias. Because population serum PCB levels at the time of sample collection were considerably higher than levels at present, it is unlikely that current PCB exposure is related to the development of either anomaly.
C1 [McGlynn, Katherine A.] NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20852 USA.
[Guo, Xuguang] Westat Corp, Durham, NC USA.
[Brock, John W.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Klebanoff, Mark A.] Eunice Kennedy Shriver NICHHD, Div Epidemiol Stat & Prevent Res, NIH, Dept Hlth & Human Serv, Rockville, MD USA.
[Longnecker, Matthew P.] NIEHS, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA.
RP McGlynn, KA (reprint author), NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, EPS Suite 550,6120 Execut Blvd, Rockville, MD 20852 USA.
EM mcglynnk@mail.nih.gov
OI Longnecker, Matthew/0000-0001-6073-5322
FU Intramural Research Programs of the National Cancer Institute; Eunice
Kennedy Shriver National Institute of Child Health and Human
Development; National Institute of Environmental Health Sciences of the
National Institutes of Health (NIH); Centers for Disease Control and
Prevention (CDC)
FX Support for this research was provided by the Intramural Research
Programs of the National Cancer Institute, the Eunice Kennedy Shriver
National Institute of Child Health and Human Development, and the
National Institute of Environmental Health Sciences of the National
Institutes of Health (NIH) and by the Centers for Disease Control and
Prevention (CDC).
NR 42
TC 37
Z9 38
U1 0
U2 4
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD SEP
PY 2009
VL 117
IS 9
BP 1472
EP 1476
DI 10.1289/ehp.0800389
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 490EE
UT WOS:000269479900040
PM 19750116
ER
PT J
AU Bugarski, AD
Schnakenberg, GH
Hummer, JA
Cauda, E
Janisko, SJ
Patts, LD
AF Bugarski, Aleksandar D.
Schnakenberg, George H., Jr.
Hummer, Jon A.
Cauda, Emanuele
Janisko, Samuel J.
Patts, Larry D.
TI Effects of Diesel Exhaust Aftertreatment Devices on Concentrations and
Size Distribution of Aerosols in Underground Mine Air
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID PARTICLE EMISSIONS; VEHICLE
AB Three types of uncatalyzed diesel particulate filter (DPF) systems, three types of high-temperature disposable filter elements (DFEs), and one diesel oxidation catalytic converter (DOC) were evaluated in underground mine conditions for their effects on the concentrations and size distributions of diesel aerosols. Those effects were compared with the effects of a standard muffler. The experimental work was conducted directly in an underground environment using a unique diesel laboratory developed in an underground experimental mine. The DPF systems reduced total mass of aerosols in the mine air approximately 10-fold for light-load and 20-fold or more for high-load test conditions. The DFEs offered similar reductions in aerosol mass concentrations. The efficiency of the new DFEs significantly increased with accumulation of operating time and buildup of diesel particulate matter in the porous structure of the filter elements. A single laundering process did not exhibit substantial effects on performance of the filter element The effectiveness of DPFs and DFEs in removing aerosols by number was strongly influenced by engine operating mode. The concentrations of nucleation mode aerosols in the mine air were found to be substantially higher for both DPFs and DFEs when the engine was operated at high-load modes than at low-load modes. The effects of the DOC on mass and number concentrations of aerosols in mine air were relatively minor when compared to those of the DPF and DFE systems.
C1 [Bugarski, Aleksandar D.; Schnakenberg, George H., Jr.; Hummer, Jon A.; Cauda, Emanuele; Janisko, Samuel J.; Patts, Larry D.] NIOSH, US Dept HHS, Publ Hlth Serv, Ctr Dis Control & Prevent,Pittsburgh Res Lab, Pittsburgh, PA 15236 USA.
RP Bugarski, AD (reprint author), NIOSH, US Dept HHS, Publ Hlth Serv, Ctr Dis Control & Prevent,Pittsburgh Res Lab, 626 Cochrans Mill Rd, Pittsburgh, PA 15236 USA.
EM abugarski@cdc.gov
RI Cauda, Emanuele/A-7168-2011
NR 23
TC 7
Z9 8
U1 1
U2 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD SEP 1
PY 2009
VL 43
IS 17
BP 6737
EP 6743
DI 10.1021/es9006355
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 487GB
UT WOS:000269258000050
PM 19764243
ER
PT J
AU Keim, SA
Branum, AM
Klebanoff, MA
Zemel, BS
AF Keim, Sarah A.
Branum, Amy M.
Klebanoff, Mark A.
Zemel, Babette S.
TI Maternal Body Mass Index and Daughters' Age at Menarche
SO EPIDEMIOLOGY
LA English
DT Article
ID FOR-GESTATIONAL-AGE; LOW-BIRTH-WEIGHT; ADOLESCENT GIRLS; BREAST-CANCER;
UNITED-STATES; PUBERTY; GROWTH; CHILDREN; HEIGHT; WOMEN
AB Background: The role of intergenerational influences on age at menarche has not been explored far beyond the association between mothers' and daughters' menarcheal ages. Small size at birth and childhood obesity have been associated with younger age at menarche, but the influence of maternal overweight or obesity on daughters' age at menarche has not been thoroughly examined.
Methods: In a follow-up study of the prospective Collaborative Perinatal Project, grown daughters were asked in 1987-1991 for their age at menarche. Data from the original Collaborative Perinatal Project (1959-1966) included their mothers' height and prepregnancy weight. In the follow-up study, 597 of 627 daughters had complete menarche and maternal data available and were included in the present analysis. We used polytomous logistic regression to examine the association between maternal overweight (body mass index [BMI] = 25-29.9 km/m(2)) or obesity (BMI >= 30) and daughter's age at menarche (<= 12, 12, 13, 14 + years).
Results: Compared with those whose mothers had a BMI less than 25, daughters of obese mothers experienced younger age at menarche (OR for menarche at <= 12 years = 3.1 [1.1-9.2]). This association remained after adjusting for maternal age at menarche, maternal parity, socioeconomic status, race, and study site (OR = 3.3 [1.1-10.0]). Effect estimates for maternal overweight were close to the null. There was limited evidence of mediation by small for gestational age or BMI at age 7.
Conclusions: Maternal obesity is associated with younger menarcheal age among daughters in this study, possibly via unmeasured shared factors.
C1 [Keim, Sarah A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Natl Childrens Study Program Off, Bethesda, MD USA.
[Keim, Sarah A.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
[Branum, Amy M.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Off Anal & Epidemiol, Infant Child & Womens Hlth Stat Branch, Hyattsville, MD 20782 USA.
[Branum, Amy M.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA.
[Klebanoff, Mark A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Epidemiol Stat & Prevent Res, Bethesda, MD USA.
[Zemel, Babette S.] Childrens Hosp Philadelphia, Div Gastroenterol Hepatol & Nutr, Philadelphia, PA 19104 USA.
RP Keim, SA (reprint author), 6100 Execut Blvd,Suite 3A01, Bethesda, MD 20892 USA.
EM Keim@nih.gov
RI Zemel, Babette/D-1117-2009; Keim, Sarah/F-8929-2013
OI Keim, Sarah/0000-0003-3490-3649
FU Intramural NIH HHS [Z01 HD000334-21]; NICHD NIH HHS [N01-HD-7-2909]
NR 40
TC 23
Z9 23
U1 2
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
J9 EPIDEMIOLOGY
JI Epidemiology
PD SEP
PY 2009
VL 20
IS 5
BP 677
EP 681
DI 10.1097/EDE.0b013e3181b093ce
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 485EJ
UT WOS:000269103500011
PM 19602980
ER
PT J
AU Darrow, LA
Klein, M
Flanders, WD
Waller, LA
Correa, A
Marcus, M
Mulholland, JA
Russell, AG
Tolbert, PE
AF Darrow, Lyndsey A.
Klein, Mitchel
Flanders, W. Dana
Waller, Lance A.
Correa, Adolfo
Marcus, Michele
Mulholland, James A.
Russell, Armistead G.
Tolbert, Paige E.
TI Ambient Air Pollution and Preterm Birth A Time-series Analysis
SO EPIDEMIOLOGY
LA English
DT Article
ID LOS-ANGELES-COUNTY; OF-THE-LITERATURE; PARTICULATE MATTER; PREGNANCY
OUTCOMES; GESTATIONAL-AGE; CALIFORNIA; EXPOSURES; HEALTH; POLLUTANTS;
AUSTRALIA
AB Background: An emerging body of evidence suggests that ambient levels of air Pollution during pregnancy are associated with preterm birth.
Methods: To further investigate these relationships we used vital record data to construct a retrospective cohort of 476,489 births occurring between 1994 and 2004 in 5 central counties of metropolitan Atlanta. Using a time-series approach, we examined aggregated daily counts of preterm birth in relation to ambient levels of carbon monoxide, nitrogen dioxide, sulfur dioxide, ozone, particulate matter <10 mu m in diameter (PM(10)), particulate matter <2.5 mu m in diameter (PM(2.5)), and speciated PM measurements. Daily pollutant levels in 5-country Atlanta were characterized using a population-weighted spatial average of air quality monitors in the study area. We also examined ambient concentrations at individual monitors in analyses limited to mothers with residential geocodes within 4 miles of each monitor. Relationships between average pollution levels during 3 gestational windows of interest were modeled using Poisson generalized linear models. Results were adjusted for seasonal and long-term time trends.
Results: Although most results were null, there were 3 positive associations between ambient pollution levels and preterm birth in the 4-mile capture-area analyses. Daily preterm birth rates were associated with average NO(2) concentrations in the preceding 6 weeks and with average PM(2.5) sulfate and PM(2.5) water-soluble metal concentrations in the preceding week.
Conclusions: Results provide limited support for late-pregnancy effects of ambient air pollution on preterm birth.
C1 [Darrow, Lyndsey A.; Klein, Mitchel; Flanders, W. Dana; Waller, Lance A.; Marcus, Michele; Tolbert, Paige E.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Correa, Adolfo] Ctr Dis Control, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Mulholland, James A.; Russell, Armistead G.] Georgia Inst Technol, Atlanta, GA 30332 USA.
RP Darrow, LA (reprint author), 1518 Clifton Rd NE, Atlanta, GA 30322 USA.
EM ldarrow@sph.emory.edu
RI Correa, Adolfo /E-7883-2011; Tolbert, Paige/A-5676-2015; Marcus,
Michele/J-2746-2015
OI Correa, Adolfo /0000-0002-9501-600X;
FU United States Environmental Protection Agency; National Institute of
Environmental Health Sciences, NIH [R01-ES-012967-02S2A1]
FX Supported by the STAR Fellowship Program of the United States
Environmental Protection Agency, and grant number R01-ES-012967-02S2A1
from the National Institute of Environmental Health Sciences, NIH.
NR 32
TC 68
Z9 68
U1 1
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
J9 EPIDEMIOLOGY
JI Epidemiology
PD SEP
PY 2009
VL 20
IS 5
BP 689
EP 698
DI 10.1097/EDE.0b013e3181a7128f
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 485EJ
UT WOS:000269103500014
PM 19478670
ER
PT J
AU Darrow, LA
Strickland, MJ
Klein, M
Waller, LA
Flanders, WD
Correa, A
Marcus, M
Tolbert, PE
AF Darrow, Lyndsey A.
Strickland, Matthew J.
Klein, Mitchel
Waller, Lance A.
Flanders, W. Dana
Correa, Adolfo
Marcus, Michele
Tolbert, Paige E.
TI Seasonality of Birth and Implications for Temporal Studies of Preterm
Birth
SO EPIDEMIOLOGY
LA English
DT Article
ID TIME-SERIES ANALYSIS; UNITED-STATES; HUMAN-REPRODUCTION;
HUMAN-FERTILITY; AIR-POLLUTION; ANNUAL RHYTHM; PREGNANCY; PATTERNS;
LONDON
AB Background: A strength of time-series analyses is the inherent control of individual-level risk factors that do not vary temporally. However, in studies of adverse pregnancy outcomes, risk factors considered time-invariant at the individual level may vary seasonally when aggregated into a pregnancy risk set. To illustrate, we describe the seasonal patterns of birth in Atlanta and demonstrate how these patterns could lead to confounding in time-series studies of seasonally-varying exposures and preterm birth.
Methods: The study cohort included all births in 20-county metropolitan Atlanta delivered during the period 1994-2004 (n = 715,875). We assessed the seasonal patterns of estimated conception and birth for the full cohort and for subgroups stratified by sociodemographic factors. Based on the observed patterns, we quantified the degree of potential confounding created by (1) differences in the gestational age distribution in the risk set across calendar months and (2) differences in the sociodemographic composition of the risk set across calendar months.
Results: The overall seasonal pattern of birth was characterized by a peak in August-September and troughs in April-May and November-January. Seasonal patterns differed among racial and ethnic groups, maternal education levels, and marital status. As a consequence of these seasonal patterns, systematic seasonal differences in the gestational age distribution and the sociodemographic composition of the risk set led to differences in expected rates of preterm birth across calendar months.
Conclusions: Time-series investigations of seasonally-varying exposures and adverse pregnancy outcomes should consider the potential for bias due to seasonal heterogeneity in the risk set.
C1 [Darrow, Lyndsey A.; Strickland, Matthew J.; Klein, Mitchel; Waller, Lance A.; Flanders, W. Dana; Marcus, Michele; Tolbert, Paige E.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Strickland, Matthew J.; Correa, Adolfo] Ctr Dis Control, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
RP Darrow, LA (reprint author), Dept Environm & Occupat Hlth, 1518 Clifton Rd NE, Atlanta, GA 30322 USA.
EM ldarrow@sph.emory.edu
RI Tolbert, Paige/A-5676-2015; Marcus, Michele/J-2746-2015
FU National Institute of Environmental Health Sciences; United States
Environmental Protection Agency [R01-ES-012967-02S2A1]
FX Supported by National Institute of Environmental Health Sciences, NIH
for the STAR Fellowship Program of the United States Environmental
Protection Agency grants (R01-ES-012967-02S2A1).
NR 27
TC 46
Z9 46
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
J9 EPIDEMIOLOGY
JI Epidemiology
PD SEP
PY 2009
VL 20
IS 5
BP 699
EP 706
DI 10.1097/EDE.0b013e3181a66e96
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 485EJ
UT WOS:000269103500015
PM 19535987
ER
PT J
AU Malik, S
Vranken, P
Silio, M
Ratard, R
Van Dyke, R
AF Malik, S.
Vranken, P.
Silio, M.
Ratard, R.
Van Dyke, R.
TI Prevalence of community-associated methicillin-resistant Staphylococcus
aureus colonization outside the healthcare environment
SO EPIDEMIOLOGY AND INFECTION
LA English
DT Article
DE Community-associated; methicillin resistance; prevalence; Staphylococcus
aureus
ID PANTON-VALENTINE LEUKOCIDIN; RISK-FACTORS; CHILDREN; INFECTIONS;
OUTBREAK; ALASKA
AB Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are increasingly recognized in persons without established risk factors. Population-based prevalence studies of CA-MRSA colonization in persons without risk factors are relatively limited. Subjects aged 2-65 years were enrolled from a student recreation Centre, public office building, and out-patient clinics. Persons or close contacts with a history of hospitalization, nursing-home residence, surgery, emergency-department visit, or healthcare employment during the previous year and persons with chronic debilitating illness, indwelling catheter, or surgical device were excluded. Swabs of anterior nares were obtained. Demographic and clinical information was collected. During January-June 2005, three (1.2%) of 259 subjects were colonized with MRSA. All three subjects were adults enrolled at the recreation Centre. Healthy persons living in households without recent exposure to healthcare environments were at low risk for MRSA colonization. Studies from other geographic locations are needed to elucidate differences in prevalence of CA-MRSA.
C1 [Malik, S.; Silio, M.; Van Dyke, R.] Tulane Univ, Sch Med, Dept Pediat Infect Dis, New Orleans, LA 70112 USA.
[Vranken, P.] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA USA.
[Vranken, P.; Ratard, R.] Louisiana Off Publ Hlth, New Orleans, LA USA.
RP Malik, S (reprint author), 518 Durham St, Bastrop, LA 71220 USA.
EM shahzadmalik@hotmail.com
NR 21
TC 10
Z9 13
U1 0
U2 5
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0950-2688
J9 EPIDEMIOL INFECT
JI Epidemiol. Infect.
PD SEP
PY 2009
VL 137
IS 9
BP 1237
EP 1241
DI 10.1017/S0950268809002222
PG 5
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 487NM
UT WOS:000269281400003
PM 19257914
ER
PT J
AU Lowe, BD
Krieg, EF
AF Lowe, Brian D.
Krieg, Edward F.
TI Relationships between observational estimates and physical measurements
of upper limb activity (vol 52, pg 569, 2009)
SO ERGONOMICS
LA English
DT Correction
C1 [Lowe, Brian D.; Krieg, Edward F.] NIOSH, Cincinnati, OH 45226 USA.
RP Lowe, BD (reprint author), NIOSH, 4676 Columbia Pkwy,MS C-24, Cincinnati, OH 45226 USA.
EM blowe@cdc.gov
NR 1
TC 0
Z9 0
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0014-0139
J9 ERGONOMICS
JI Ergonomics
PD SEP
PY 2009
VL 52
IS 9
BP 1183
EP 1183
DI 10.1080/00140130903148761
PG 1
WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology
SC Engineering; Psychology
GA 492VZ
UT WOS:000269691800014
ER
PT J
AU Bethel, JW
Waterman, SH
AF Bethel, Jeffrey W.
Waterman, Stephen H.
TI KNOWLEDGE, ATTITUDES AND PRACTICES REGARDING INFLUENZA PREVENTION AND
CONTROL MEASURES AMONG HISPANICS IN SAN DIEGO COUNTY-2006
SO ETHNICITY & DISEASE
LA English
DT Article
DE Hispanic; Latino; Influenza; Immigrant; Vaccination; Knowledge;
Awareness; Practices
ID UNITED-STATES; VACCINATION; EPIDEMICS; COMMUNITY; ADULTS
AB Background: Influenza vaccination is the most effective method to avoid influenza virus infection and its potential serious complications; however, influenza vaccine is underutilized especially among minority groups.
Objectives: We assessed the knowledge, attitudes, and practices (KAP) regarding influenza prevention and control measures among Hispanics in San Diego County.
Methods: We used a multistage cluster sampling scheme to administer an in-person, door-to-door KAP survey to 226 Hispanics aged >= 18 years in three regions of San Diego County during July-August 2006.
Results: Hispanics in the three regions sampled for this survey varied widely by age, country of birth, years living in the United States, number of border crossings in previous month, and number of people in household. Awareness of the influenza vaccine was nearly 90% among survey respondents. The percentage of Hispanic males and females aged 50-64 years who received an influenza vaccination in the previous 12 months was 7.7% and 23.5%, respectively, and the percentage of Hispanic males and females aged >= 65 years who received an influenza vaccination in the previous 12 months was 33.3% and 59.1%, respectively.
Conclusions: This survey showed high awareness of the influenza vaccine among Hispanics in San Diego County but relatively low vaccination rates among respondents aged >= 50 years, a group targeted for influenza vaccination. Differences in awareness and vaccination rates between Hispanic males and females across all age groups indicate that educational outreach efforts should specifically target Hispanic men. (Ethn Dis. 2009;19:377-383)
C1 [Bethel, Jeffrey W.] E Carolina Univ, Brody Sch Med, Dept Publ Hlth, Greenville, NC 27834 USA.
[Bethel, Jeffrey W.; Waterman, Stephen H.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, San Diego, CA USA.
RP Bethel, JW (reprint author), E Carolina Univ, Brody Sch Med, Dept Publ Hlth, Hardy Bldg,600 Moye Blvd, Greenville, NC 27834 USA.
EM bethelj@ecu.edu
NR 27
TC 2
Z9 2
U1 0
U2 1
PU INT SOC HYPERTENSION BLACKS-ISHIB
PI ATLANTA
PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA
SN 1049-510X
J9 ETHNIC DIS
JI Ethn. Dis.
PD FAL
PY 2009
VL 19
IS 4
BP 377
EP 383
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 530XA
UT WOS:000272624700001
PM 20073136
ER
PT J
AU Moonesinghe, R
Jones, W
Honore, PA
Truman, BI
Graham, G
AF Moonesinghe, Ramal
Jones, Walter
Honore, Peggy A.
Truman, Benedict I.
Graham, Garth
TI GENOMIC MEDICINE AND RACIAL/ETHNIC HEALTH DISPARITIES: PROMISES, PERILS,
AND THE CHALLENGES FOR HEALTH CARE AND PUBLIC HEALTH POLICY
SO ETHNICITY & DISEASE
LA English
DT Article
DE Genomic Medicine; Allele Frequency; Healthcare Disparity; Genetic Tests
ID BIOMEDICAL-RESEARCH; RACE; GENETICS; HISTORY; WILL
AB Scientific and policy debates following new genetic discoveries have been intense and emotional when they have involved questions about the causes of, and solutions for, racial and ethnic health disparities in the United States. The difference in prevalence of diseases, allele frequency and genotype frequency among racial/ethnic groups are well known. The genomic profile for a given disease could have different genetic variants for different racial/ethnic groups. Do these results indicate that we have to consider different genetic tests and different genomic medicine for different racial/ethnic groups? If we do this, what is the impact on ethnic and class disparities in health care services in the United States?
Current advances in genetic medicine are very promising; however, we must consider the possible impacts of these findings on health disparities, and how genetic medicine can be extended to everyone, not just those who can pay the often high price. If genomic medicine is to be a valid and reliable technology for all citizens regardless of wealth, race, ethnicity, or other determinants of social disadvantage, public health policymakers have to consider a number of policy issues and implications. (Ethn Dis. 2009;19:473-478)
C1 [Honore, Peggy A.; Graham, Garth] US Dept HHS, Off Publ Hlth & Sci, Off Minor Hlth, Rockville, MD 20852 USA.
[Moonesinghe, Ramal; Truman, Benedict I.] Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Atlanta, GA USA.
[Jones, Walter] Med Univ S Caroline, Coll Hlth Profess, Columbia, SC USA.
RP Honore, PA (reprint author), US Dept HHS, Off Publ Hlth & Sci, Off Minor Hlth, 1101 Wootton Pkwy,Suite 600, Rockville, MD 20852 USA.
EM Peggy.Honore@hhs.gov
NR 49
TC 5
Z9 5
U1 0
U2 2
PU INT SOC HYPERTENSION BLACKS-ISHIB
PI ATLANTA
PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA
SN 1049-510X
J9 ETHNIC DIS
JI Ethn. Dis.
PD FAL
PY 2009
VL 19
IS 4
BP 473
EP 478
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 530XA
UT WOS:000272624700016
PM 20073151
ER
PT J
AU Lee, E
Stone, GW
Mehran, R
Cox, DA
Bertrand, ME
Lincoff, AM
Ohman, EM
White, HD
Hooper, WC
Dangas, GD
AF Lee, E.
Stone, G. W.
Mehran, R.
Cox, D. A.
Bertrand, M. E.
Lincoff, A. M.
Ohman, E. M.
White, H. D.
Hooper, W. C.
Dangas, G. D.
TI The predictive value of CRP on 30-Day and 1-year mortality in acute
coronary syndromes: An analysis from the ACUITY trial
SO EUROPEAN HEART JOURNAL
LA English
DT Meeting Abstract
C1 [Lee, E.] Columbia Univ, Med Ctr, New York, NY USA.
[Stone, G. W.; Mehran, R.; Dangas, G. D.] Cardiovasc Res Fdn, New York, NY USA.
[Bertrand, M. E.] CHRU Lille, Hop Cardiol, Lille, France.
[Lincoff, A. M.] Cleveland Clin, Cleveland, OH 44106 USA.
[Ohman, E. M.] Duke Univ, Med Ctr, Durham, NC 27706 USA.
[White, H. D.] Auckland City Hosp, Auckland, New Zealand.
[Hooper, W. C.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
J9 EUR HEART J
JI Eur. Heart J.
PD SEP
PY 2009
VL 30
SU 1
BP 619
EP 619
PG 1
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA V28TH
UT WOS:000208702605118
ER
PT J
AU Arras, JD
Fenton, EM
AF Arras, John D.
Fenton, Elizabeth M.
TI ACCESS TO HEALTH-RELATED GOODS
SO HASTINGS CENTER REPORT
LA English
DT Article
ID HUMAN-RIGHTS; TRIALS; STEPS; CARE
C1 [Arras, John D.] Univ Virginia, Charlottesville, VA 22903 USA.
[Arras, John D.] Ctr Dis Control & Prevent, Eth Comm, Atlanta, GA USA.
RP Arras, JD (reprint author), Univ Virginia, Charlottesville, VA 22903 USA.
NR 45
TC 8
Z9 10
U1 0
U2 0
PU HASTINGS CENTER
PI BRIARCLIFF MANOR
PA 255 ELM ROAD, BRIARCLIFF MANOR, NY 10510 USA
SN 0093-0334
J9 HASTINGS CENT REP
JI Hastings Cent. Rep.
PD SEP-OCT
PY 2009
VL 39
IS 5
BP 27
EP 38
PG 12
WC Ethics; Health Care Sciences & Services; Medical Ethics; Social
Sciences, Biomedical
SC Social Sciences - Other Topics; Health Care Sciences & Services; Medical
Ethics; Biomedical Social Sciences
GA 499JF
UT WOS:000270215000019
PM 19806778
ER
PT J
AU Finkelstein, EA
Trogdon, JG
Cohen, JW
Dietz, W
AF Finkelstein, Eric A.
Trogdon, Justin G.
Cohen, Joel W.
Dietz, William
TI Annual Medical Spending Attributable To Obesity: Payer- And
Service-Specific Estimates
SO HEALTH AFFAIRS
LA English
DT Article
AB In 1998 the medical costs of obesity were estimated to be as high as $ 78.5 billion, with roughly half financed by Medicare and Medicaid. This analysis presents updated estimates of the costs of obesity for the United States across payers (Medicare, Medicaid, and private insurers), in separate categories for inpatient, non-inpatient, and prescription drug spending. We found that the increased prevalence of obesity is responsible for almost $ 40 billion of increased medical spending through 2006, including $ 7 billion in Medicare prescription drug costs. We estimate that the medical costs of obesity could have risen to $ 147 billion per year by 2008. [Health Affairs 28, no. 5 (2009): w822-w831 (published online 27 July 2009; 10.1377/hlthaff.28.5.w822)]
C1 [Finkelstein, Eric A.; Trogdon, Justin G.] RTI Int, Publ Hlth Econ Program, Res Triangle Pk, NC USA.
[Cohen, Joel W.] Agcy Healthcare Res & Qual, Div Social & Econ Res, Ctr Financing Access & Cost Trends, Rockville, MD USA.
[Dietz, William] Ctr Dis Control & Prevent, Div Nutr & Phys Act, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
RP Finkelstein, EA (reprint author), RTI Int, Publ Hlth Econ Program, Res Triangle Pk, NC USA.
EM finkelse@rti.org
FU CDC Foundation
FX Eric Finkelstein and Justin Trogdon received external support for this
work through a contract with the CDC Foundation. The authors thank
Charles Feagan for his research assistance.
NR 9
TC 848
Z9 860
U1 13
U2 95
PU PROJECT HOPE
PI BETHESDA
PA 7500 OLD GEORGETOWN RD, STE 600, BETHESDA, MD 20814-6133 USA
SN 0278-2715
J9 HEALTH AFFAIR
JI Health Aff.
PD SEP-OCT
PY 2009
VL 28
IS 5
BP W822
EP W831
DI 10.1377/hlthaff.28.5.w822
PG 10
WC Health Care Sciences & Services; Health Policy & Services
SC Health Care Sciences & Services
GA 492HP
UT WOS:000269646100058
PM 19635784
ER
PT J
AU LaBone, ED
Farfan, EB
Lee, PL
Jannik, GT
Donnelly, EH
Foley, TQ
AF LaBone, Elizabeth D.
Farfan, Eduardo B.
Lee, Patricia L.
Jannik, G. Timothy
Donnelly, Elizabeth H.
Foley, Trevor Q.
TI ASSESSMENT OF RADIONUCLIDE DATABASES IN CAP88 MAINFRAME VERSION 1.0 AND
WINDOWS-BASED VERSION 3.0
SO HEALTH PHYSICS
LA English
DT Article
DE dose assessment; dose, population; dosimetry; modeling, dose assessment
AB In this study the radionuclide databases for two versions of the Clean Air Act Assessment Package-1988 (CAP88) computer model were assessed in detail. CAP88 estimates radiation dose and the risk of health effects to human populations from radionuclide emissions to air. This program is used by several U.S. Department of Energy (DOE) facilities to comply with National Emission Standards for Hazardous Air Pollutants regulations. CAP88 Mainframe, referred to as version 1.0 on the U.S. Environmental Protection Agency Web site (http://www.epa.gov/radiation/assessment/CAP88/), was the very first CAP88 version released in 1988. Some DOE facilities including the Savannah River Site still employ this version (1.0) while others use the more user-friendly personal computer Windows-based version 3.0 released in December 2007. Version 1.0 uses the program RADRISK based on International Commission on Radiological Protection Publication 30 as its radionuclide database. Version 3.0 uses half-life, dose, and risk factor values based on Federal Guidance Report 13. Differences in these values could cause different results for the same input exposure data (same scenario), depending on which version of CAP88 is used. Consequently, the differences between the two versions are being assessed in detail at Savannah River National Laboratory. The version 1.0 and 3.0 database riles contain 496 and 838 radionuclides, respectively, and though one would expect the newer version to include all the 496 radionuclides, 35 radionuclides are listed in version 1.0 that are not included in version 3.0. The majority of these has either extremely short or long half-lives or is no longer in production; however, some of the short-lived radionuclides might produce progeny of great interest at DOE sites. In addition, 122 radionuclides were found to have different half-lives in the two versions, with 21 over 3 percent different and 12 over 10 percent different. Health Phys. 97(3):242-247; 2009
C1 [Farfan, Eduardo B.] Savannah River Nucl Solut LLC, Savannah River Natl Lab, Environm Sci & Biotechnol, Environm Anal Sect, Aiken, SC 29808 USA.
[LaBone, Elizabeth D.] Univ S Carolina, Columbia, SC 29208 USA.
[Donnelly, Elizabeth H.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
RP Farfan, EB (reprint author), Savannah River Nucl Solut LLC, Savannah River Natl Lab, Environm Sci & Biotechnol, Environm Anal Sect, 773-42A,Room 236, Aiken, SC 29808 USA.
EM Eduardo.Farfan@srnl.doe.gov
NR 6
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0017-9078
EI 1538-5159
J9 HEALTH PHYS
JI Health Phys.
PD SEP
PY 2009
VL 97
IS 3
BP 242
EP 247
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical
Imaging
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Nuclear Science & Technology; Radiology, Nuclear Medicine &
Medical Imaging
GA 482TJ
UT WOS:000268911300007
PM 19667807
ER
PT J
AU Cordovado, SK
Hancock, LN
Hendrix, M
Greene, CN
Mueller, PW
AF Cordovado, Suzanne Kehoe
Hancock, Laura N.
Hendrix, Miyono
Greene, Christopher N.
Mueller, Patricia W.
TI Novel human leukocyte antigen class I and class II alleles identified by
sequence-based typing in the Genetics of Kidneys in Diabetes (GoKinD)
study population
SO HUMAN IMMUNOLOGY
LA English
DT Article
DE HLA-A; HLA-C; HLA-DQB1; HLA-DPB1; GoKinD; Sequence based typing/DNA;
Type 1 diabetes
ID SUSCEPTIBILITY; NEPHROPATHY; HLA-DQA1; DPB1
AB Nine novel HLA class I and class II alleles were identified by sequence-based typing (SBT) in Caucasian participants from the Genetics of Kidneys in Diabetes (GoKinD) study. All novel alleles were single nucleotide substitutions. Seven alleles resulted in an amino acid change and two alleles were silent substitutions. The new alleles are as follows: five HILA-A alleles (*0132, *020121, *0344, *030107, *2507), one HLA-C allele (*0619), two HLA-DQB1 alleles (*0204, *0318), and one HLA-DPB1 allele (*1802). Eight of these new alleles were identified in participants with type I diabetes, three of whom also had diabetic nephropathy, and one new allele was identified in an unaffected parent of a participant with type 1 diabetes. All new alleles were isolated and characterized by use of single allele amplification (SAA) SBT; the new alleles were confirmed by sequence-specific primer (SSP) amplification. Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.
C1 [Cordovado, Suzanne Kehoe; Hancock, Laura N.; Hendrix, Miyono; Greene, Christopher N.; Mueller, Patricia W.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Newborn Screening & Mol Biol Branch, Atlanta, GA 30333 USA.
RP Cordovado, SK (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Newborn Screening & Mol Biol Branch, Atlanta, GA 30333 USA.
EM snc4@cdc.gov
FU Juvenile Diabetes Research Foundation in collaboration with the Joslin
Diabetes Center, George Washington University Biostatistics Center; CDC;
Special Statutory Funding Program for Type 1 Diabetes Research, National
Institutes of Health [PL-105-33, PL-106-554, PL-107-360]
FX The sample collection of the Genetics and Kidneys in Diabetes (GoKinD)
study was supported by the Juvenile Diabetes Research Foundation in
collaboration with the Joslin Diabetes Center, George Washington
University Biostatistics Center, and CDC. The GoKinD study received
funding from the Special Statutory Funding Program for Type 1 Diabetes
Research (PL-105-33, PL-106-554, and PL-107-360) administered by the
National Institutes of Health.
NR 20
TC 1
Z9 1
U1 1
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0198-8859
J9 HUM IMMUNOL
JI Hum. Immunol.
PD SEP
PY 2009
VL 70
IS 9
BP 747
EP 749
DI 10.1016/j.humimm.2009.06.011
PG 3
WC Immunology
SC Immunology
GA 493CV
UT WOS:000269711800015
PM 19539002
ER
PT J
AU Hvidtjorn, D
Grove, J
Schendel, D
Schieve, LA
Ernst, E
Olsen, J
Thorsen, P
AF Hvidtjorn, D.
Grove, J.
Schendel, D.
Schieve, L. A.
Ernst, E.
Olsen, J.
Thorsen, P.
TI Validation of self-reported data on assisted conception in The Danish
National Birth Cohort
SO HUMAN REPRODUCTION
LA English
DT Article
DE validation; self-report; assisted conception; Danish National Birth
Cohort
ID REPRODUCTIVE TECHNOLOGY; RELIABILITY; WOMEN; VALIDITY; CANCER; SYSTEM
AB An increasing number of children are born after assisted conception and in surveillance programmes information on mode of conception is often achieved via maternal self-report. We assessed the validity of self-reported assisted conception in The Danish National Birth Cohort (DNBC), a prospective pregnancy cohort. Here, the term assisted conception refers to IVF, ICSI, ovulation induction and insemination.
We compared self-reported assisted conception in the DNBC to corresponding data from Danish national registers; the IVF Register and Danish Drug Prescription Register, providing method of conception in the entire population. In the DNBC, 101 042 women accepted the invitation in early pregnancy from 1996 to 2002. Our final study population comprised 88 151 DNBC women aged 20 years and older who participated in the first DNBC interview with a pregnancy resulting in a live born child.
In the DNBC, assisted conception was reported with a sensitivity of 83% and positive predictive value of 88%. Misclassification was largely explained by ambiguous phrasing of the DNBC interview question and interview skip patterns. Women with false negative reporting were more often multipara (P < 0.001) and older (P = 0.027 for IVF/ICSI and P = 0.002 for ovulation induction). The risk ratio (RR) for being born preterm in IVF/ICSI children was lower for children identified via the DNBC, RR 3.61 (95% confidence interval (CI) 3.31-3.94), than the IVF Register, RR 4.36 (95% CI 4.02-4.74).
There was a high positive predictive value of self-reported assisted conception in the DNBC, but the structure of the DNBC interview represented a problem and misclassification could introduce bias.
C1 [Hvidtjorn, D.; Grove, J.; Thorsen, P.] Univ Aarhus, Dept Epidemiol, Inst Publ Hlth, NANEA, DK-8000 Aarhus, Denmark.
[Schendel, D.; Schieve, L. A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30345 USA.
[Ernst, E.] Skejby Univ Hosp, Reprod Lab, DK-8200 Aarhus, Denmark.
[Olsen, J.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA.
[Thorsen, P.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
RP Hvidtjorn, D (reprint author), Univ Aarhus, Dept Epidemiol, Inst Publ Hlth, NANEA, DK-8000 Aarhus, Denmark.
EM dh@soci.au.dk
RI Olsen, Jorn/F-8801-2015;
OI Olsen, Jorn/0000-0001-7462-5140; Grove, Jakob/0000-0003-2284-5744
NR 18
TC 18
Z9 18
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1161
J9 HUM REPROD
JI Hum. Reprod.
PD SEP
PY 2009
VL 24
IS 9
BP 2332
EP 2340
DI 10.1093/humrep/dep179
PG 9
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 483WH
UT WOS:000269001600032
PM 19454590
ER
PT J
AU Rao, CY
Pachucki, C
Cali, S
Santhiraj, M
Krankoski, KLK
Noble-Wang, JA
Leehey, D
Popli, S
Brandt, ME
Lindsley, MD
Fridkin, SK
Arduino, MJ
AF Rao, Carol Y.
Pachucki, Constance
Cali, Salvatore
Santhiraj, Mangai
Krankoski, Kathi L. K.
Noble-Wang, Judith A.
Leehey, David
Popli, Subhash
Brandt, Mary E.
Lindsley, Mark D.
Fridkin, Scott K.
Arduino, Matthew J.
TI Contaminated Product Water as the Source of Phialemonium curvatum
Bloodstream Infection among Patients Undergoing Hemodialysis
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Article
ID GRAM-NEGATIVE BACTEREMIA; NATIONAL SURVEILLANCE; PYROGENIC REACTIONS;
UNITED-STATES; OUTBREAK; DIALYSIS; MACHINE; ENDOCARDITIS; OBOVATUM;
PORTS
AB OBJECTIVE. We investigated a cluster of cases of bloodstream infection (BSI) due to the mold Phialemonium at a hemodialysis center in Illinois and conducted a cohort study to identify risk factors.
DESIGN. Environmental assessment and cohort study.
SETTING. A hemodialysis center in a tertiary care hospital.
METHODS. A case patient was defined as a person who underwent dialysis at the center and had a blood sample that tested positive for Phialemonium curvatum on culture. We reviewed microbiology and medical records and tested water, surface, and dialysate samples by culture. Molds isolated from environmental and clinical specimens were identified by their morphological features and confirmed by sequencing DNA.
RESULTS. We identified 2 case patients with BSI due to P. curvatum. Both became febrile and hypotensive while undergoing dialysis on the same machine at the same treatment station, although on different days. Dialysis machines were equipped with waste handling option ports that are used to discard dialyzer priming fluid. We isolated P. curvatum from the product water (ie, water used for dialysis purposes) at 2 of 19 treatment stations, one of which was the implicated station.
CONCLUSION. The source of P. curvatum was likely the water distribution system. To our knowledge, this is the first report of patients acquiring a mold BSI from contaminated product water. The route of exposure in these cases of BSI due to P. curvatum may be related to the malfunction and improper maintenance of the waste handling option ports. Waste handling option ports have been previously implicated as the source of bacterial BSI due to the backflow of waste fluid into a patient's blood line. No additional cases of infection were noted after remediation of the water distribution system and after discontinuing use of waste handling option ports at the facility. Infect Control Hosp Epidemiol 2009; 30: 840-847
C1 [Rao, Carol Y.; Noble-Wang, Judith A.; Fridkin, Scott K.; Arduino, Matthew J.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
[Brandt, Mary E.; Lindsley, Mark D.] Ctr Dis Control & Prevent, Div Foodborne Bacterial & Mycot Dis, Atlanta, GA 30333 USA.
[Pachucki, Constance; Santhiraj, Mangai; Krankoski, Kathi L. K.; Leehey, David; Popli, Subhash] US Dept Vet Affairs, Vet Affairs Edward Hines Jr Hosp, Hines, IL 60141 USA.
[Cali, Salvatore] Univ Illinois, Sch Publ Hlth, Chicago, IL USA.
RP Rao, CY (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd,Mailstop A-35, Atlanta, GA 30333 USA.
EM cnr3@cdc.gov
RI Arduino, Matthew/C-1461-2012
OI Arduino, Matthew/0000-0001-7072-538X
FU Centers for Disease Control and Prevention [U50/CCU524174-01]
FX S.C. was supported by cooperative agreement U50/CCU524174-01 from the
Centers for Disease Control and Prevention. Potential conflicts of
interest. All authors report no conflicts of interest relevant to this
article.
NR 37
TC 9
Z9 9
U1 1
U2 4
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0899-823X
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD SEP
PY 2009
VL 30
IS 9
BP 840
EP 847
DI 10.1086/605324
PG 8
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 479TR
UT WOS:000268684300004
PM 19614543
ER
PT J
AU Wang, SH
Pancholi, P
Stevenson, K
Yakrus, MA
Butler, WR
Schlesinger, LS
Mangino, JE
AF Wang, Shu-Hua
Pancholi, Preeti
Stevenson, Kurt
Yakrus, Mitchell A.
Butler, W. Ray
Schlesinger, Larry S.
Mangino, Julie E.
TI Pseudo-Outbreak of "Mycobacterium paraffinicum" Infection and/or
Colonization in a Tertiary Care Medical Center
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Article; Proceedings Paper
CT 18th Annual Scientific Meeting of the
Society-for-Healthcare-Epidemiology-of-America
CY APR 05-08, 2008
CL Orlando, FL
SP Soc Healthcare Epidemiol Amer
ID NONTUBERCULOUS MYCOBACTERIA; WATER; PARASCROFULACEUM; IDENTIFICATION;
MACHINE; COMPLEX; SIMIAE
AB OBJECTIVE. To investigate a pseudo-outbreak of "Mycobacterium paraffinicum" (unofficial taxon) infection and/or colonization, using isolates recovered from clinical and environmental specimens.
DESIGN. Outbreak investigation.
SETTING. University-affiliated, tertiary-care hospital.
METHODS. M. paraffinicum, a slow-growing, nontuberculous species of mycobacteria, was recovered from 21 patients and an ice machine on a single patient care unit over a 2.5-year period. The clinical, epidemiological, and environmental investigation of this pseudo-outbreak is described.
RESULTS. Twenty-one patients with pulmonary symptoms and possible risk factors for tuberculosis were admitted to inpatient rooms that provided airborne isolation conditions in 2 adjacent hospital buildings. In addition, 1 outpatient had induced sputum cultured for mycobacteria in the pulmonary function laboratory. Of the samples obtained from these 21 patients, 26 isolates from respiratory samples and 1 isolate from a stool sample were identified as M. paraffinicum. Environmental isolates obtained from an ice machine in the patient care unit where the majority of the patients were admitted were also identified as M. paraffinicum.
CONCLUSIONS. An epidemiological investigation that used molecular tools confirmed the suspicion of a pseudo-outbreak of M. paraffinicum infection and/or colonization. The hospital water system was identified as the source of contamination. Infect Control Hosp Epidemiol 2009; 30: 848-853
C1 [Wang, Shu-Hua; Stevenson, Kurt; Schlesinger, Larry S.; Mangino, Julie E.] Ohio State Univ, Med Ctr, Ctr Microbial Interface Biol, Div Infect Dis,Dept Internal Med, Columbus, OH 43210 USA.
[Pancholi, Preeti] Ohio State Univ, Med Ctr, Div Clin Microbiol, Dept Pathol, Columbus, OH 43210 USA.
[Yakrus, Mitchell A.; Butler, W. Ray] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA.
RP Wang, SH (reprint author), N-1120 Doan Hall,410 W 10th Ave, Columbus, OH 43210 USA.
EM Shu-Hua.Wang@osumc.edu
NR 23
TC 8
Z9 8
U1 0
U2 3
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0899-823X
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD SEP
PY 2009
VL 30
IS 9
BP 848
EP 853
DI 10.1086/599071
PG 6
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 479TR
UT WOS:000268684300005
PM 19653819
ER
PT J
AU Thompson, ND
Novak, RT
Datta, D
Cotter, S
Arduino, MJ
Patel, PR
Williams, IT
Bialek, SR
AF Thompson, Nicola D.
Novak, Ryan T.
Datta, Deblina
Cotter, Susanne
Arduino, Matthew J.
Patel, Priti R.
Williams, Ian T.
Bialek, Stephanie R.
TI Hepatitis C Virus Transmission in Hemodialysis Units: Importance of
Infection Control Practices and Aseptic Technique
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Article
ID HEALTH-CARE
AB We investigated 4 hepatitis C virus (HCV) infection outbreaks at hemodialysis units to identify practices associated with transmission. Apparent failures to follow recommended infection control precautions resulted in patient-to-patient HCV transmission, through cross-contamination of the environment or intravenous medication vials. Fastidious attention to aseptic technique and infection control precautions are essential to prevent HCV transmission. Infect Control Hosp Epidemiol 2009; 30: 900-903
C1 [Thompson, Nicola D.; Novak, Ryan T.; Datta, Deblina; Cotter, Susanne; Williams, Ian T.; Bialek, Stephanie R.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
[Arduino, Matthew J.; Patel, Priti R.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA USA.
RP Thompson, ND (reprint author), 1600 Clifton Rd,NE,Mail Stop G-37, Atlanta, GA 30333 USA.
EM ndthompson@cdc.gov
RI Arduino, Matthew/C-1461-2012
OI Arduino, Matthew/0000-0001-7072-538X
NR 10
TC 24
Z9 25
U1 2
U2 4
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0899-823X
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD SEP
PY 2009
VL 30
IS 9
BP 900
EP 903
DI 10.1086/605472
PG 4
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 479TR
UT WOS:000268684300014
PM 19642900
ER
PT J
AU Xu, J
Yang, Y
Wang, C
Jiang, B
AF Xu, Jin
Yang, Y.
Wang, C.
Jiang, B.
TI Rotavirus and coxsackievirus infection activated different profiles of
toll-like receptors and chemokines in intestinal epithelial cells
SO INFLAMMATION RESEARCH
LA English
DT Article
DE Rotavirus; Coxsackievirus B3; TLR; Chemokine
ID RESPIRATORY SYNCYTIAL VIRUS; DOUBLE-STRANDED-RNA; CYTOKINE RESPONSES;
IMMUNE-RESPONSE; B VIRUSES; KAPPA-B; RECOGNITION; EXPRESSION; CHILDREN;
TLR4
AB To understand the inflammatory-immune response in intestinal epithelial cells after infection of rotavirus and coxsackievirus B3.
We examined by quantitative PCR the expression profiles of genes encoding five toll-like receptors (TLR) and levels of three chemokines in response to rotavirus and coxsackievirus B3 infection in a human intestinal epithelial cell line (HT-29 cells).
We demonstrated that rotavirus induced significantly increased levels of mRNA expression for TLR2, TLR3, TLR7 and TLR8 in HT-29 cells in a time-dependent manner. In contrast, coxsackievirus B3 did not stimulate mRNA expression for TLR3. Rotavirus and coxsackievirus B3 also induced higher levels of mRNA expression for RANTES, IP-10 and IL-8 during the period of infection in a different manner. Finally, significantly elevated levels of RANTES, IP-10 and IL-8 were detected by ELISA in rotavirus-infected cells from 24 to 48 h.
Our findings suggest that different patterns of TLRs and chemokines were induced in the initiation and modulation of immune response to rotavirus and coxsackievirus B3 infection.
C1 [Xu, Jin; Yang, Y.; Wang, C.] Fudan Univ, Inst Pediat, Childrens Hosp, Shanghai 200032, Peoples R China.
[Jiang, B.] Ctr Dis Control & Prevent, Gastroenteritis & Resp Virus Lab Branch, Div Viral Dis, Atlanta, GA 30333 USA.
RP Xu, J (reprint author), Fudan Univ, Inst Pediat, Childrens Hosp, 183 Fenglin Rd, Shanghai 200032, Peoples R China.
EM janexu125@hotmail.com
FU Fudan University, China
FX This research was supported by a grant from Fudan University, China.
NR 38
TC 20
Z9 25
U1 1
U2 5
PU BIRKHAUSER VERLAG AG
PI BASEL
PA VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND
SN 1023-3830
J9 INFLAMM RES
JI Inflamm. Res.
PD SEP
PY 2009
VL 58
IS 9
BP 585
EP 592
DI 10.1007/s00011-009-0022-x
PG 8
WC Cell Biology; Immunology
SC Cell Biology; Immunology
GA 475AJ
UT WOS:000268326500006
PM 19296205
ER
PT J
AU Pourbohloul, B
Ahued, A
Davoudi, B
Meza, R
Meyers, LA
Skowronski, DM
Villasenor, I
Galvan, F
Cravioto, P
Earn, DJD
Dushoff, J
Fisman, D
Edmunds, WJ
Hupert, N
Scarpino, SV
Trujillo, J
Lutzow, M
Morales, J
Contreras, A
Chavez, C
Patrick, DM
Brunham, RC
AF Pourbohloul, Babak
Ahued, Armando
Davoudi, Bahman
Meza, Rafael
Meyers, Lauren A.
Skowronski, Danuta M.
Villasenor, Ignacio
Galvan, Fernando
Cravioto, Patricia
Earn, David J. D.
Dushoff, Jonathan
Fisman, David
Edmunds, W. John
Hupert, Nathaniel
Scarpino, Samuel V.
Trujillo, Jesus
Lutzow, Miguel
Morales, Jorge
Contreras, Ada
Chavez, Carolina
Patrick, David M.
Brunham, Robert C.
TI Initial human transmission dynamics of the pandemic (H1N1) 2009 virus in
North America
SO INFLUENZA AND OTHER RESPIRATORY VIRUSES
LA English
DT Article
DE Epidemiologic methods; infectious disease outbreak; influenza; initial
reproduction number; pandemic
ID INFLUENZA; SARS; STRATEGIES
AB Background
Between 5 and 25 April 2009, pandemic (H1N1) 2009 caused a substantial, severe outbreak in Mexico, and subsequently developed into the first global pandemic in 41 years. We determined the reproduction number of pandemic (H1N1) 2009 by analyzing the dynamics of the complete case series in Mexico City during this early period.
Methods
We analyzed three mutually exclusive datasets from Mexico City Distrito Federal which constituted all suspect cases from 15 March to 25 April: confirmed pandemic (H1N1) 2009 infections, non-pandemic influenza A infections and patients who tested negative for influenza. We estimated the initial reproduction number from 497 suspect cases identified prior to 20 April, using a novel contact network methodology incorporating dates of symptom onset and hospitalization, variation in contact rates, extrinsic sociological factors, and uncertainties in underreporting and disease progression. We tested the robustness of this estimate using both the subset of laboratory-confirmed pandemic (H1N1) 2009 infections and an extended case series through 25 April, adjusted for suspected ascertainment bias.
Results
The initial reproduction number (95% confidence interval range) for this novel virus is 1 center dot 51 (1 center dot 32-1 center dot 71) based on suspected cases and 1 center dot 43 (1 center dot 29-1 center dot 57) based on confirmed cases before 20 April. The longer time series (through 25 April) yielded a higher estimate of 2 center dot 04 (1 center dot 84-2 center dot 25), which reduced to 1 center dot 44 (1 center dot 38-1 center dot 51) after correction for ascertainment bias.
Conclusions
The estimated transmission characteristics of pandemic (H1N1) 2009 suggest that pharmaceutical and non-pharmaceutical mitigation measures may appreciably limit its spread prior the development of an effective vaccine.
C1 [Pourbohloul, Babak; Davoudi, Bahman; Meza, Rafael; Brunham, Robert C.] British Columbia Ctr Dis Control, Div Math Modeling, Vancouver, BC V5Z 4R4, Canada.
[Pourbohloul, Babak] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V5Z 1M9, Canada.
[Ahued, Armando; Villasenor, Ignacio; Cravioto, Patricia; Trujillo, Jesus; Lutzow, Miguel; Morales, Jorge; Contreras, Ada; Chavez, Carolina] Secretaria Salud Dist Fed, Mexico City, DF, Mexico.
[Meyers, Lauren A.; Scarpino, Samuel V.] Univ Texas Austin, Sect Integrat Biol, Austin, TX 78712 USA.
[Skowronski, Danuta M.; Patrick, David M.] British Columbia Ctr Dis Control, Div Epidemiol Serv, Vancouver, BC V5Z 4R4, Canada.
[Galvan, Fernando] Secretaria Salud Mexico, Gen Directorate Epidemiol, Mexico City, DF, Mexico.
[Earn, David J. D.; Dushoff, Jonathan] McMaster Univ, Dept Math & Stat, Hamilton, ON, Canada.
[Fisman, David] Univ Toronto, Toronto, ON, Canada.
[Edmunds, W. John] Univ London, London Sch Hyg & Trop Med, London, England.
[Hupert, Nathaniel] Weill Cornell Med Coll, New York, NY USA.
[Hupert, Nathaniel] Ctr Dis Control & Prevent, Preparedness Modeling Unit, Atlanta, GA USA.
RP Pourbohloul, B (reprint author), British Columbia Ctr Dis Control, Div Math Modeling, 655 W 12th Ave, Vancouver, BC V5Z 4R4, Canada.
EM babak.pourbohloul@bccdc.ca
FU Canadian Institutes of Health Research (CIHR) [PTL-93146, PTL-97125,
PAP-93425, MOP-81273]; Provincial Health Services Authority of BC
(PHSA); Canadian Consortium for Pandemic Preparedness Modeling (CanPan);
BC Pandemic Influenza Accelerated Vaccine Initiative (PANAVI); Michael
Smith Foundation for Health Research (MSFHR); NIGMS Models of Infectious
Disease Agent Study (MIDAS) [1-U01-GM087719-01]; National Science
Foundation [DEB-0749097]; James F. McDonnell Foundation
FX We would generous support of the Secretaria de Salud del Distrito
Federal, for providing epidemiological data and insight. This work was
supported by the Canadian Institutes of Health Research (CIHR) (grants
nos. PTL-93146, PTL-97125, PAP-93425 and MOP-81273), Provincial Health
Services Authority of BC (PHSA), Canadian Consortium for Pandemic
Preparedness Modeling (CanPan) and BC Pandemic Influenza Accelerated
Vaccine Initiative (PANAVI). BP is grateful for the support of the CIHR
and the Michael Smith Foundation for Health Research (MSFHR). LAM would
like to acknowledge the support of the NIGMS Models of Infectious
Disease Agent Study (MIDAS) (1-U01-GM087719-01), the National Science
Foundation (DEB-0749097), and the James F. McDonnell Foundation.
NR 24
TC 81
Z9 85
U1 2
U2 11
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1750-2640
J9 INFLUENZA OTHER RESP
JI Influenza Other Respir. Viruses
PD SEP
PY 2009
VL 3
IS 5
BP 215
EP 222
DI 10.1111/j.1750-2659.2009.00100.x
PG 8
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA 484YM
UT WOS:000269086700006
PM 19702583
ER
PT J
AU Yu, HJ
Feng, LZ
Peng, ZB
Feng, ZJ
Shay, DK
Yang, WZ
AF Yu, Hongjie
Feng, Luzhao
Peng, Zhibin
Feng, Zijian
Shay, David K.
Yang, Weizhong
TI Estimates of the impact of a future influenza pandemic in China
SO INFLUENZA AND OTHER RESPIRATORY VIRUSES
LA English
DT Article
DE Influenza pandemic; Monte-Carlo method; China; health planning
ID NONPHARMACEUTICAL INTERVENTIONS; UNITED-STATES; MORTALITY; NETHERLANDS;
AGE
AB Background
The next influenza pandemic will create a surge in demand for health resources in China, with its current population of > 1 center dot 3 billion persons and under-developed medical care and public health system. However, few pandemic impact data are available for China.
Objectives
We estimated the effects of a future influenza pandemic in China by examining pandemic scenarios of varying severity and described the time distribution of cases during a first wave.
Methods
We used a Monte-Carlo simulation model and death rates, hospitalizations and outpatient visits for 1918- and 1968-like pandemic scenarios and data from the literature or experts' opinion to estimate four health outcomes: deaths, hospitalizations, outpatient medical visits and clinical illness for which medical care was not sought. For each of the two scenarios we estimated outcomes by week using a normal distribution.
Results
We estimated that a 1968 scenario in China would result in 460 000-700 000 deaths, 1 center dot 94-2 center dot 27 million hospitalizations, 111-117 million outpatient visits and 192-197 million illnesses for which medical care was not sought. Fifty-two percent of hospitalizations occurred during the two-peak weeks of the first wave. We estimated that patients at high-risk of influenza complications (10-17% of the population) would account for 61-75% of all deaths. For a 1918 scenario, we estimated that 4 center dot 95-6 center dot 95 million deaths, 20 center dot 8-22 center dot 7 million hospitalizations and 101-108 million outpatient visits could occur.
Conclusion
Even a 1968 pandemic scenario will pose substantial challenges for the medical and public health system in China, and planning to manage these challenges is essential.
C1 [Yu, Hongjie; Feng, Luzhao; Peng, Zhibin; Feng, Zijian; Yang, Weizhong] Chinese Ctr Dis Control & Prevent China CDC, Off Dis Control & Emergency Response, Beijing 100050, Peoples R China.
[Shay, David K.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Coordinating Ctr Infect Dis, Ne Atlanta, GA USA.
RP Yang, WZ (reprint author), Chinese Ctr Dis Control & Prevent China CDC, Off Dis Control & Emergency Response, 27 Nanwei Rd, Beijing 100050, Peoples R China.
EM yangwz@chinacdc.cn
OI Shay, David/0000-0001-9619-4820
FU China-US Collaborative Program on Emerging and Re-emerging Infectious
Diseases; Ministry of Science and Technology of the People's Republic of
China [2004BA519A71]
FX The views expressed in this study are those of the authors and do not
represent the policy of the Chinese Center for Disease Control and
Prevention or the Centers for Disease Control and Prevention, USA.; This
study was supported by grants from the China-US Collaborative Program on
Emerging and Re-emerging Infectious Diseases and the Ministry of Science
and Technology of the People's Republic of China (2004BA519A71).
NR 41
TC 4
Z9 4
U1 1
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1750-2640
EI 1750-2659
J9 INFLUENZA OTHER RESP
JI Influenza Other Respir. Viruses
PD SEP
PY 2009
VL 3
IS 5
BP 223
EP 231
DI 10.1111/j.1750-2659.2009.00093.x
PG 9
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA 484YM
UT WOS:000269086700007
PM 21462394
ER
PT J
AU Lee, EK
Chen, CH
Pietz, F
Benecke, B
AF Lee, Eva K.
Chen, Chien-Hung
Pietz, Ferdinand
Benecke, Bernard
TI Modeling and Optimizing the Public-Health Infrastructure for Emergency
Response
SO INTERFACES
LA English
DT Article
DE public health; emergency response; mass dispensing; resource allocation;
facility location; disease propagation; medical countermeasures;
bioterrorism; pandemic; infectious disease; anthrax; disaster medicine;
all-hazard emergency response; public-health informatics; integer
programming; simulation; decision-support system
ID OPERATIONS-RESEARCH; PANDEMIC INFLUENZA; STRATEGIES; VACCINATION; ATTACK
AB Public-health emergencies, such as bioterrorist attacks or pandemics, demand fast, efficient, large-scale dispensing of critical medical countermeasures. By combining mathematical modeling, large-scale simulation, and powerful optimization engines, and coupling them with automatic graph-drawing tools and a user-friendly interface, we designed and implemented RealOpt (c), a fast and practical emergency-response decision-support tool. RealOpt allows public-health emergency coordinators to (1) determine locations for point-of-dispensing (POD) facility setup; (2) design customized and efficient floor plans for PODs via an automatic graph-drawing tool; (3) determine required labor resources and provide efficient placement of staff at individual stations within a POD; (4) perform disease-propagation analysis, understand and monitor the intra-POD disease dilemma, and help to derive dynamic response strategies to mitigate casualties; (5) assess resources and determine minimum needs to prepare for treating their regional populations in emergency situations; (6) carry out large-scale virtual drills and performance analyses, and investigate alternative strategies; and (7) design a variety of dispensing scenarios that include emergency-event exercises to train personnel. These advanced and powerful computational strategies allow emergency coordinators to quickly analyze design decisions, generate feasible regional dispensing plans based on best estimates and analyses available, and reconfigure PODs as an event unfolds. The ability to analyze planning strategies, compare the various options, and determine the most cost-effective combination of dispensing strategies is critical to the ultimate success of any mass dispensing effort.
C1 [Lee, Eva K.; Chen, Chien-Hung] Georgia Inst Technol, Sch Ind & Syst Engn, Ctr Operat Res Med & HealthCare, Atlanta, GA 30332 USA.
[Lee, Eva K.; Chen, Chien-Hung] Georgia Inst Technol, NSF I UCRC Ctr Hlth Org Transformat, Atlanta, GA 30332 USA.
[Pietz, Ferdinand; Benecke, Bernard] Ctr Dis Control & Prevent, Coordinating Off Terrorism Preparedness & Emergen, Atlanta, GA 30333 USA.
RP Lee, EK (reprint author), Georgia Inst Technol, Sch Ind & Syst Engn, Ctr Operat Res Med & HealthCare, Atlanta, GA 30332 USA.
EM eva.lee@gatech.edu; cchen@isye.gatech.edu
NR 28
TC 26
Z9 27
U1 3
U2 30
PU INFORMS
PI HANOVER
PA 7240 PARKWAY DR, STE 310, HANOVER, MD 21076-1344 USA
SN 0092-2102
J9 INTERFACES
JI Interfaces
PD SEP-OCT
PY 2009
VL 39
IS 5
BP 476
EP 490
DI 10.1287/inte.1090.0463
PG 15
WC Management; Operations Research & Management Science
SC Business & Economics; Operations Research & Management Science
GA 503WL
UT WOS:000270572300008
ER
PT J
AU Bott, AM
Bruce, MG
Bulkow, L
Coleman, J
Hennessy, TW
AF Bott, Anne M.
Bruce, Michael G.
Bulkow, Lisa
Coleman, John
Hennessy, Thomas W.
TI TRENDS IN ANTIMICROBIAL PRESCRIBING RATES FOR ALASKA NATIVE AND AMERICAN
INDIAN PERSONS < 18 YEARS OF AGE RESIDING IN THE ANCHORAGE REGION
SO INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
LA English
DT Article
DE antimicrobial prescribing; Alaska Native children; antibiotic;
prescription rates; AI/AN
ID OUTPATIENT ANTIBIOTIC USE; UNITED-STATES; EUROPEAN SURVEILLANCE;
CONSUMPTION ESAC; RURAL ALASKA; RESISTANCE; PHYSICIANS
AB Objectives. In the U S., the total number of antimicrobials prescribed in ambulatory care declined between 1989 and 2000: however. antimicrobial resistance increased among many pathogens We evaluated antimicrobial prescribing patterns from 1992 to 2004 in Alaska Native/American Indian (AI/AN) persons <18 years old, residing in the Anchorage region who received care through the AI/AN health system
Study design. Retrospective study based oil medical records.
Methods. Medical records were Used to obtain data oil oral antibiotics prescribed for ambulatory and emergency-room visits. Anti-microbial prescribing rates were calculated per population and per ambulatory-clinic visit
Results. The total number of antimicrobial courses prescribed increased 94% from 4.929 (1992) to 9.561 (2004) However. the total number of ambulatory-clinic visits also increased (79%) from 49.008 (1992) to 87.486 (2004), while the population of AI/AN persons <18 in Anchorage region rose 14%. The population-based rate of antimicrobial prescriptions (per 1,000 persons) rose from 309 (1992) to 524 (2004) (1)<0.001). The visit-based annual rate (per 1,000 visits) remained stable from 101 (1992) to 109 (2004) (p=0.651) Overall. visit-based prescription rates in AI/AN persons Were lower than previously reported among children in the U.S. (range 250-340). Penicillins comprised >50% of antimicrobials prescribed from 1992 to 2004 Visit-based prescribing rates from 1992 to 2004 changed: penicillin, +27% (p=0.210), cephalosporins. +33% (p=0 023); trimethoprim-sulfamethexazole, -48% (p<0.001).
Conclusions. Visit-based antimicrobial prescribing rates in the Anchorage region for AI/AN children receiving care in the AI/AN health system have been stable over a 13-year period. Although a trend in decreased antibiotic prescribing has been seen in the general U.S. population. visit-based prescribing rate,; in the Anchorage region for AI/AN children have remained below those in previous studies in the U.S. (Int J Circumpolar Health 2009; 68(4):337-346)
C1 [Bruce, Michael G.; Bulkow, Lisa; Hennessy, Thomas W.] Ctr Dis Control & Prevent, Arctic Invest Program, Natl Ctr Preparedness Detect & Control Infect Dis, Anchorage, AK 99508 USA.
[Bott, Anne M.] Alaska Native Med Ctr, Anchorage, AK USA.
[Coleman, John] Santa Fe Indian Hosp, Santa Fe, NM USA.
RP Bruce, MG (reprint author), Ctr Dis Control & Prevent, Arctic Invest Program, Natl Ctr Preparedness Detect & Control Infect Dis, 4055 Tudor Ctr Dr, Anchorage, AK 99508 USA.
EM zwa8@cdc.gov
NR 18
TC 3
Z9 3
U1 0
U2 1
PU INT ASSOC CIRCUMPOLAR HEALTH PUBL
PI OULU
PA AAPISTIE1, OULU, FIN-90220, FINLAND
SN 1239-9736
J9 INT J CIRCUMPOL HEAL
JI Int. J. Circumpolar Health
PD SEP
PY 2009
VL 68
IS 4
BP 337
EP 346
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 510OO
UT WOS:000271099600005
PM 19917186
ER
PT J
AU Ruckart, PZ
Orr, M
Palaszewska-Tkacz, A
Dewan, A
Kapil, V
AF Ruckart, Perri Zeitz
Orr, Maureen
Palaszewska-Tkacz, Anna
Dewan, Aruna
Kapil, Vikas
TI A US Partnership with India and Poland to Track Acute Chemical Releases
to Serve Public Health
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE chemical surveillance; chemical release; public health
ID SURVEILLANCE; INCIDENTS
AB We describe a collaborative effort between the U. S., India, and Poland to track acute chemical releases during 2005-2007. In all three countries, fixed facility events were more common than transportation-related events; manufacturing and transportation/warehousing were the most frequently involved industries; and equipment failure and human error were the primary contributing factors. The most commonly released non-petroleum substances were ammonia ( India), carbon monoxide ( U. S.) and mercury ( Poland). More events in India (54%) resulted in victims compared with Poland (15%) and the U. S. (9%). The pilot program showed it is possible to successfully conduct international surveillance of acute hazardous substances releases with careful interpretation of the findings.
C1 [Ruckart, Perri Zeitz; Orr, Maureen] Agcy Tox Subst & Dis Registry, Atlanta, GA 30341 USA.
[Palaszewska-Tkacz, Anna] Nofer Inst Occupat Med, Dept Informat Sci, PL-91348 Lodz, Poland.
[Dewan, Aruna] Natl Inst Occupat Hlth NIOH, Ahmadabad 380016, Gujarat, India.
[Kapil, Vikas] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA.
RP Ruckart, PZ (reprint author), Agcy Tox Subst & Dis Registry, 4770 Buford Highway,MS F57, Atlanta, GA 30341 USA.
EM pruckart@cdc.gov; morr@cdc.gov; apalasz@imp.lodz.pl;
dewanaruna@yahoo.com; vkapil@cdc.gov
RI palaszewska-tkacz, anna/G-4909-2010
NR 13
TC 0
Z9 0
U1 0
U2 1
PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
PI BASEL
PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2009
VL 6
IS 9
BP 2375
EP 2386
DI 10.3390/ijerph6092375
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 499DW
UT WOS:000270198300004
PM 19826549
ER
PT J
AU Graff, JJ
Sathiakumar, N
Macaluso, M
Maldonado, G
Matthews, R
Delzell, E
AF Graff, John J.
Sathiakumar, Nalini
Macaluso, Maurizio
Maldonado, George
Matthews, Robert
Delzell, Elizabeth
TI The Effect of Uncertainty in Exposure Estimation on the
Exposure-Response Relation between 1,3-Butadiene and Leukemia
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE 1,3-butadiene; epidemiology; methods; leukemia; workplace exposures;
uncertainty analysis
ID SYNTHETIC RUBBER INDUSTRY; NONDIFFERENTIAL MISCLASSIFICATION;
SENSITIVITY-ANALYSIS; DIFFERENTIAL MISCLASSIFICATION; BIAS; ASSIGNMENT;
BUTADIENE; WORKERS; STYRENE; CANCER
AB In a follow-up study of mortality among North American synthetic rubber industry workers, cumulative exposure to 1,3-butadiene was positively associated with leukemia. Problems with historical exposure estimation, however, may have distorted the association. To evaluate the impact of potential inaccuracies in exposure estimation, we conducted uncertainty analyses of the relation between cumulative exposure to butadiene and leukemia. We created the 1,000 sets of butadiene estimates using job-exposure matrices consisting of exposure values that corresponded to randomly selected percentiles of the approximate probability distribution of plant-, work area/job group-, and year specific butadiene ppm. We then analyzed the relation between cumulative exposure to butadiene and leukemia for each of the 1,000 sets of butadiene estimates. In the uncertainty analysis, the point estimate of the RR for the first non zero exposure category (>0-<37.5 ppm-years) was most likely to be about 1.5. The rate ratio for the second exposure category (37.5-<184.7 ppm-years) was most likely to range from 1.5 to 1.8. The RR for category 3 of exposure (184.7-<425.0 ppm-years) was most likely between 2.1 and 3.0. The RR for the highest exposure category (425.0+ ppm-years) was likely to be between 2.9 and 3.7. This range off RR point estimates can best be interpreted as a probability distribution that describes our uncertainty in RR point estimates due to uncertainty in exposure estimation. After considering the complete probability distributions of butadiene exposure estimates, the exposure-response association of butadiene and leukemia was maintained. This exercise was a unique example of how uncertainty analyses can be used to investigate and support an observed measure of effect when occupational exposure estimates are employed in the absence of direct exposure measurements.
C1 [Graff, John J.] Wayne State Univ, Sch Med, Karmanos Canc Inst, Detroit, MI 48201 USA.
[Graff, John J.; Sathiakumar, Nalini; Macaluso, Maurizio; Matthews, Robert; Delzell, Elizabeth] Univ Alabama, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.
[Macaluso, Maurizio] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA.
[Maldonado, George] Univ Minnesota, Sch Publ Hlth, Div Environm Hlth Sci, Minneapolis, MN 55455 USA.
RP Graff, JJ (reprint author), Wayne State Univ, Sch Med, Karmanos Canc Inst, Detroit, MI 48201 USA.
EM graffj@karmanos.org; nalini@uab.edu; mum0@cdc.gov; gmphd@umn.edu;
rsm@uab.edu; eduedelzell@uab.edu
RI Macaluso, Maurizio/J-2076-2015
OI Macaluso, Maurizio/0000-0002-2977-9690
NR 28
TC 2
Z9 2
U1 0
U2 5
PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
PI BASEL
PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2009
VL 6
IS 9
BP 2436
EP 2455
DI 10.3390/ijerph6092436
PG 20
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 499DW
UT WOS:000270198300010
PM 19826555
ER
PT J
AU Yuan, J
Liu, YF
Yang, ZC
Cai, YS
Deng, ZA
Qin, PZ
Li, TG
Dong, ZQ
Yan, ZQ
Zhou, DH
Luo, HM
Ma, HL
Pang, XL
Fontaine, RE
AF Yuan, Jun
Liu, Yufei
Yang, Zhicong
Cai, Yanshan
Deng, Zhiai
Qin, Pengzhe
Li, Tiegang
Dong, Zhiqiang
Yan, Ziqiang
Zhou, Duanhua
Luo, Huiming
Ma, Huilai
Pang, Xinglin
Fontaine, Robert E.
TI Mycobacterium abscessus post-injection abscesses from extrinsic
contamination of multiple-dose bottles of normal saline in a rural
clinic
SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Mycobacterium chelonae; Hospital infections; Disease outbreaks; Abscess;
Injection
ID HEALTH-CARE SETTINGS; NONTUBERCULOUS MYCOBACTERIA; WOUND INFECTIONS;
OUTBREAK; MESOTHERAPY; MASSILIENSE; SURGERY
AB Background: We investigated an outbreak of gluteal abscesses following intramuscular (IM) injections given at a clinic in rural China to identify the causative agent, source, and method of exposure.
Methods: We defined a case as an abscess that appeared at the site of an injection given since June 1, 2006. We compared case rates by injection route, medication, and diluents. We reviewed injection practices, and cultured abscesses and environmental sites for mycobacteria.
Results: From October through December 2006, 5.8% (n = 35) of 604 persons who had received injections at the clinic developed a case. All 35 cases occurred in 184 patients (attack rate = 19.0%) who had received IM injections with various drugs that had been mixed with normal saline (NS); risk ratio = infinity; p < 0.0001. No cases occurred in the absence of NS exposure. We identified Mycobacterium abscessus from eight abscesses and from the clinic water supply, and observed the inappropriate reuse of a 16-gauge needle left in the rubber septum of 100 ml multiple-dose bottles of NS in the clinic. Fourteen percent (n = 527) of the 3887 registered residents of this village had been treated with IM drugs over a three-month period, often for minor illnesses.
Conclusions: This outbreak of M. abscessus occurred from exposure to extrinsically contaminated NS through improper injection practices. Frequent treatment of minor illnesses with IM injections of antibiotics was likely an important contributing factor to the size of this outbreak. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
C1 [Yuan, Jun; Liu, Yufei; Yang, Zhicong; Cai, Yanshan; Deng, Zhiai; Qin, Pengzhe; Li, Tiegang; Dong, Zhiqiang; Yan, Ziqiang] Guangzhou Ctr Dis Control & Prevent, Guangzhou 510080, Guangdong, Peoples R China.
[Yuan, Jun; Ma, Huilai; Fontaine, Robert E.] Chinese Field Epidemiol Training Program, Beijing, Peoples R China.
[Zhou, Duanhua] Guangzhou Hlth Bur, Guangzhou, Guangdong, Peoples R China.
[Fontaine, Robert E.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Yang, ZC (reprint author), Guangzhou Ctr Dis Control & Prevent, Guangzhou 510080, Guangdong, Peoples R China.
EM yangzc@gzcdc.org.cn
NR 30
TC 15
Z9 15
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1201-9712
J9 INT J INFECT DIS
JI Int. J. Infect. Dis.
PD SEP
PY 2009
VL 13
IS 5
BP 537
EP 542
DI 10.1016/j.ijid.2008.11.024
PG 6
WC Infectious Diseases
SC Infectious Diseases
GA 498HB
UT WOS:000270126900003
PM 19269204
ER
PT J
AU Jenke, C
Harmsen, D
Weniger, T
Hyytia-Trees, E
Karch, H
Mellmann, A
AF Jenke, C.
Harmsen, D.
Weniger, T.
Hyytiae-Trees, E.
Karch, H.
Mellmann, A.
TI Phylogeny and clonal distribution of enterohemorrhagic Escherichia coli
O157 isolates in Germany from 1987 to 2008 based on MLVA typing
SO INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
LA English
DT Meeting Abstract
CT 61st Conference of the
Deutschen-Gesellschaft-fur-Hygiene-und-Microbiologie
CY SEP 20-23, 2009
CL Gottingen, GERMANY
SP Deutsch Gesell Hygiene & Microbiol
C1 [Jenke, C.; Mellmann, A.] WWU Munster, Inst Hyg, Munster, Germany.
[Harmsen, D.; Weniger, T.; Karch, H.] WWU Munster, Poliklin Parodontol, Munster, Germany.
[Hyytiae-Trees, E.] Ctr Dis Control & Prevent, PulseNet Methods Dev & Reference Unit, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 1438-4221
J9 INT J MED MICROBIOL
JI Int. J. Med. Microbiol.
PD SEP
PY 2009
VL 299
BP 72
EP 72
PG 1
WC Microbiology; Virology
SC Microbiology; Virology
GA 492JF
UT WOS:000269650700300
ER
PT J
AU Bliven, EE
Podewils, LJ
AF Bliven, E. E.
Podewils, L. J.
TI The role of chronic hepatitis in isoniazid hepatotoxicity during
treatment for latent tuberculosis infection
SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
LA English
DT Review
DE hepatotoxicity; latent tuberculosis infection; chronic viral hepatitis
ID HUMAN-IMMUNODEFICIENCY-VIRUS; UNITED-STATES; PREVENTIVE THERAPY; C
VIRUS; TRANSPLANT RECIPIENTS; RANDOMIZED-TRIAL; B CARRIERS; DRUG-USERS;
PYRAZINAMIDE; PREVALENCE
AB BACKGROUND: To examine chronic viral hepatitis (CVH) as a risk factor for hepatotoxicity during isoniazid (INH) treatment for latent tuberculosis infection (LTBI). METHODS: A search of MEDLINE (1966-May 2008) was conducted using the terms 'tuberculosis', 'antitubercular', 'therapeutics', 'treatment', 'prevention', 'prophylaxis', 'hepatitis', 'toxic hepatitis', 'hepatotoxic', 'liver' and 'injury'. Peer-reviewed, English-language articles describing the relationship between a history of CVH and occurrence of hepatotoxicity during LTBI treatment were selected. We limited CVH diagnoses to reports with positive serological test or biopsy for hepatitis B or C. Risk ratios and 95% confidence intervals were abstracted or derived.
RESULTS: We reviewed 486 abstracts, and 11 studies met the selection criteria. Populations included in the studies were the general population (n = 6) and transplant recipients (n = 5). The variability in study designs and case finding practices precluded performing a quantitative meta-analysis. Two studies of former or current drug users reported a consistent, positive association between chronic hepatitis C infection and INH hepatotoxicity. Other risk ratios did not significantly or consistently show any association between CVH in patients treated for LTBI and the development of INH hepatotoxicity.
CONCLUSION: Owing to the limited number of published papers, CVH was not established as a risk factor for INH hepatotoxicity during LTBI treatment. Controlled studies are needed to define the safety and tolerability of LTBI treatment in those with CVH and to provide an evidence base for recommendations for LTBI treatment in persons with CVH.
C1 [Bliven, E. E.] Ctr Dis Control & Prevent, Div TB Eliminat, NCHHSTP, Atlanta, GA 30333 USA.
RP Bliven, EE (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, NCHHSTP, 1600 Clifton Rd NE,Mailstop E-10, Atlanta, GA 30333 USA.
EM ebliven@cdc.gov
FU Centers for Disease Control and Prevention, Atlanta, Georgia
FX The authors thank M E Villarino, A Vernon and E McCray for their
continued support at the CDC. Authors EEB and LJP are funded through the
Division of Tuberculosis Elimination at the Centers for Disease Control
and Prevention, Atlanta, Georgia.
NR 38
TC 16
Z9 19
U1 1
U2 3
PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
PI PARIS
PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE
SN 1027-3719
EI 1815-7920
J9 INT J TUBERC LUNG D
JI Int. J. Tuberc. Lung Dis.
PD SEP
PY 2009
VL 13
IS 9
BP 1054
EP 1060
PG 7
WC Infectious Diseases; Respiratory System
SC Infectious Diseases; Respiratory System
GA 484JD
UT WOS:000269039600003
PM 19723392
ER
PT J
AU Manangan, L
Elmore, K
Lewis, B
Pratt, R
Armstrong, L
Davison, J
Santibanez, S
Heetderks, A
Robison, V
Lee, V
Navin, T
AF Manangan, L.
Elmore, K.
Lewis, B.
Pratt, R.
Armstrong, L.
Davison, J.
Santibanez, S.
Heetderks, A.
Robison, V.
Lee, V.
Navin, T.
TI Disparities in tuberculosis between Asian/Pacific Islanders and
non-Hispanic Whites, United States, 1993-2006
SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
LA English
DT Article
DE Asian/Pacific Islander; tuberculosis; health disparities; non-Hispanic
White
ID DRUG-RESISTANT TUBERCULOSIS; FOREIGN-BORN PERSONS; EXTRAPULMONARY
TUBERCULOSIS; RISK-FACTORS
AB SETTING: The United States (US) National Tuberculosis Surveillance System (NTSS), including 50 states, District of Columbia, and New York City.
OBJECTIVE: To examine disparities in characteristics and rates of Asian/Pacific Islander (API) and non-Hispanic White tuberculosis (TB) patients.
DESIGN: Descriptive analysis and logistic regression of selected 1993-2006 NTSS data. US Census Bureau Zip Code Tabulation Areas and geographic information system were used to compare API and non-Hispanic White TB patients by population density.
RESULT: Of 253299 TB cases, 1.9.8% were APIs and 23.2% were Whites; 94.2% APIs and 11.9% Whites were foreign-born. Factors that were most often associated with APIs were being female, age 15-24 years, extrapulmonary TB, and drug resistance. APIs were less likely than Whites to be human immunodeficiency virus (HIV) positive, homeless, substance abusers, or on directly observed therapy. From 1993 to 2006, the API TB case rate declined by 42.9% vs. 66.6% in Whites (P < 0.01). Being foreign-born was the strongest risk factor for TB, regardless of population densities, but APIs were more likely to have TB than foreign-born Whites at lower population densities.
CONCLUSION: Disparities in TB exist among US APIs and non-Hispanic Whites. TB program officials should allocate programs appropriately for foreign-born APIs in lower population density areas.
C1 [Manangan, L.; Armstrong, L.; Heetderks, A.; Robison, V.; Navin, T.] Ctr Dis Control & Prevent, Div TB Eliminat, NCHHSTP, Atlanta, GA 30333 USA.
[Pratt, R.] CDC, Agcy Tox Subst & Dis Registry, Natl Ctr Environm Hlth, Div Hlth Studies,Geospatial Res Anal & Serv Progr, Atlanta, GA USA.
[Davison, J.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Santibanez, S.] CDC, Off Hlth Dispar, NCHHSTP, Atlanta, GA 30333 USA.
RP Manangan, L (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, NCHHSTP, 1600 Clifton Rd,Mailstop E-10, Atlanta, GA 30333 USA.
EM lpm2@cdc.gov
NR 27
TC 4
Z9 5
U1 1
U2 3
PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
PI PARIS
PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE
SN 1027-3719
J9 INT J TUBERC LUNG D
JI Int. J. Tuberc. Lung Dis.
PD SEP
PY 2009
VL 13
IS 9
BP 1077
EP 1085
PG 9
WC Infectious Diseases; Respiratory System
SC Infectious Diseases; Respiratory System
GA 484JD
UT WOS:000269039600006
PM 19723395
ER
PT J
AU Lowrance, DW
Ndamage, F
Kayirangwa, E
Ndagije, F
Lo, W
Hoover, DR
Hanson, J
Elul, B
Ayaba, A
Ellerbrock, T
Rukundo, A
Shumbusho, F
Nash, D
Mugabo, J
Assimwe, A
AF Lowrance, David W.
Ndamage, Francois
Kayirangwa, Eugenie
Ndagije, Felix
Lo, Wilson
Hoover, Donald R.
Hanson, Jeff
Elul, Batya
Ayaba, Aliou
Ellerbrock, Tedd
Rukundo, Alphonse
Shumbusho, Fabienne
Nash, Denis
Mugabo, Jules
Assimwe, Anita
TI Adult Clinical and Immunologic Outcomes of the National Antiretroviral
Treatment Program in Rwanda During 2004-2005
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE Africa; antiretroviral treatment; national; outcomes; Rwanda
ID SUB-SAHARAN AFRICA; SCALING-UP; COTRIMOXAZOLE PROPHYLAXIS;
HIV-1-INFECTED ADULTS; EARLY MORTALITY; SOUTH-AFRICA; THERAPY; MALAWI;
HIV; AIDS
AB Background: By December 2007, over 48,000 persons had initiated antiretroviral treatment (ART) at 171 clinics in Rwanda. Assessing national ART program outcomes is essential to determine whether programs have the desired impact.
Methods: We conducted a retrospective cohort study to assess key 6- and 12-month outcomes among a nationally representative, stratified, random sample of 3194 adults (>= 15 years) who initiated ART from January 1, 2004, through December 31, 2005.
Findings: At ART initiation, the median patient age was 37 years and 65% were female. Overall, the baseline median CD4(+) cell Count was 141 cells per microliter. At 6 and 12 months after ART initiation, 92% and 86% of patients, respectively, remained on ART at their original site. By 6 months, 3.6% were dead and 3.4% were lost to follow-up; by 12 months, 4.6%, were dead and 4.9% were lost to follow-up. Among patients with available follow-up CD4(+) cell count data, median CD4(+) cell counts increased by 98 cells per microliter and H 9 cells per microliter at 6 and 12 months after ART initiation, respectively.
Conclusions: Rwanda's national ART program achieved excellent 6- and 12-month retention and immunologic outcomes during the first 2 years of rapid scale-up. Routine supervision is required to improve compliance with clinical guidelines and data quality.
C1 [Lowrance, David W.; Kayirangwa, Eugenie; Ndagije, Felix; Ayaba, Aliou] US Ctr Dis Control & Prevent, Global AIDS Program, Kigali, Rwanda.
[Lowrance, David W.; Ndamage, Francois; Rukundo, Alphonse; Mugabo, Jules; Assimwe, Anita] Minist Hlth, TRACPlus Ctr Treatment & Res HIV AIDS Malaria TB, Kigali, Rwanda.
[Ndagije, Felix] Columbia Univ, Mailman Sch Publ Hlth, Int Ctr AIDS Care & Treatment Programs, Kigali, Rwanda.
[Lo, Wilson; Elul, Batya; Nash, Denis] Columbia Univ, Mailman Sch Publ Hlth, Int Ctr AIDS Care & Treatment Programs, New York, NY USA.
[Hoover, Donald R.] Rutgers State Univ, Camden, NJ 08102 USA.
[Hanson, Jeff] US Ctr Dis Control & Prevent, Global AIDS Program, Windhoek, Namibia.
[Ellerbrock, Tedd] US Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA USA.
[Rukundo, Alphonse] Natl Inst Stat Rwanda, Kigali, Rwanda.
[Shumbusho, Fabienne] Family Hlth Int, Kigali, Rwanda.
RP Lowrance, DW (reprint author), US Ctr Dis Control & Prevent, Global AIDS Program, Kigali, Rwanda.
EM lowrance@rw.cdc.gov
NR 31
TC 43
Z9 44
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD SEP 1
PY 2009
VL 52
IS 1
BP 49
EP 55
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 488TQ
UT WOS:000269373400007
PM 19617847
ER
PT J
AU Feng, LG
Ding, XB
Lu, RR
Liu, J
Sy, AL
Ouyang, L
Pan, CB
Yi, HR
Liu, HH
Xu, J
Zhao, JK
AF Feng, Liangui
Ding, Xianbin
Lu, Rongrong
Liu, Jie
Sy, Aileen
Ouyang, Lin
Pan, Chuanbo
Yi, Huirong
Liu, Honghong
Xu, Jing
Zhao, Jinkou
TI High HIV Prevalence Detected in 2006 and 2007 Among Men Who Have Sex
With Men in China's Largest Municipality: An Alarming Epidemic in
Chongqing, China
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE China; Chongqing; epidemiology; HIV-1; MSM; syphilis
ID RISK BEHAVIOR; SYPHILIS; SURVEILLANCE; TRANSMISSION; INFECTIONS;
HIV/AIDS; JIANGSU
AB Background: Data from many large cities in China show HIV prevalence among men who have sex with men (MSM) increasing dramatically over the recent years, making HIV transmission among MSM in China a growing concern. To facilitate targeted HIV prevention among MSM in Chongqing, Surveys were conducted to examine HIV prevalence and its associated factors in 2006 and in 2007.
Methods: Surveys were conducted in 2006 and 2007 in 3 districts of Chongqing at venues and cruising areas where MSM frequent. Univariate and bivariate analysis were conducted on demographic, behavioral, and biological data.
Results: HIV prevalence was 19.7% in 2006 and 26.5% in 2007 among recruitees from bathhouses and saunas, more than 2 times higher than recruitees from other venues for both years. HIV prevalence increased from 10.4% in 2006 to 12.5% in 2007. HIV prevalence was more than 20% among those older than 40 years of age, much higher than HIV prevalence in younger age groups. HIV prevalence among married MSM was 15.9% in 2006 and 20.9% in 2007, compared with nonmarried MSM at 7.6% in 2006 and 9.2% in 2007.
Discussion: Urgent attention for prevention services is required to address the overall high HIV prevalence among MSM in the city, with special focus on subgroups as older, married MSM, and those recruited from bathhouses and saunas.
C1 [Zhao, Jinkou] Bill & Melinda Gates Fdn, Beijing Representat Off, Beijing 100005, Peoples R China.
[Liu, Jie] Assoc Sch Publ Hlth, CDC Allan Rosenfield Global Hlth Fellow, Atlanta, GA USA.
[Sy, Aileen] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Pan, Chuanbo] Yuzhong Dist Ctr Dis Control & Prevent, Chongqing, Peoples R China.
[Yi, Huirong] Jiulongpo Dist Ctr Dis Control & Prevent, Chongqing, Peoples R China.
[Liu, Honghong] Shapingba Dist Ctr Dis Control & Prevent, Chongqing, Peoples R China.
[Feng, Liangui; Ding, Xianbin; Lu, Rongrong; Ouyang, Lin; Xu, Jing] Chongqing Municipal Ctr Dis Control & Prevent, Chongqing, Peoples R China.
RP Zhao, JK (reprint author), Bill & Melinda Gates Fdn, Beijing Representat Off, Suite 1201,China Resources Bldg,8 Jianguomenbei A, Beijing 100005, Peoples R China.
EM jinkouzhao@hotmail.com
FU Global Fund for AIDS, Tuberculosis, and Malaria
FX Supported by Global Fund for AIDS, Tuberculosis, and Malaria.
NR 25
TC 71
Z9 80
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD SEP 1
PY 2009
VL 52
IS 1
BP 79
EP 85
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 488TQ
UT WOS:000269373400012
PM 19448559
ER
PT J
AU Cohen, AL
Salam, A
Bosan, A
Perry, R
Iqbal, S
Qureshi, SN
Cairns, L
Mach, O
Mahoney, F
Hafiz, R
AF Cohen, Adam L.
Salam, Abdul
Bosan, Altaf
Perry, Robert
Iqbal, Syma
Qureshi, Shaista Noor
Cairns, Lisa
Mach, Ondrej
Mahoney, Frank
Hafiz, Rehan
TI Etiology of a Suspected Measles Outbreak: Preceding Measles Reduction
Activities in Pakistan
SO JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
LA English
DT Article
DE Disease outbreaks; Measles; Pakistan; Rubella
ID EASTERN MEDITERRANEAN REGION; MORTALITY REDUCTION; ELIMINATION
AB Objective: To characterize patients with suspected measles, determine the magnitude of the outbreak in selected areas, and perform laboratory testing on patients with suspected measles to confirm the etiology of the outbreak.
Study Design: Cross-sectional survey.
Place and Duration of Study: Islamabad and Rawalpindi in June 2006.
Methodology: Survey and specimen collection from households was carried out in areas affected by rash and fever during the outbreak. Teams asked if household members had rash and fever and administered a detailed questionnaire of clinical signs and symptoms for measles for each person who reported a rash and fever episode. A sample of cases with fever, rash, and either cough, conjunctivitis, or coryza was laboratory tested for measles and rubella.
Results: Of 2,225 households visited, 284 individuals met the rash and fever case definition. Laboratory testing of eleven blood specimens revealed that the rash and fever outbreak was caused by rubella in 6 and measles in 2 with three equivocal results.
Conclusion: Laboratory confirmation of suspected measles cases is essential during measles elimination activities in Pakistan and other countries with endemic rubella.
C1 [Cohen, Adam L.] Ctr Dis Control & Prevent, Resp Dis Branch, Div Bacterial Dis, Atlanta, GA 30333 USA.
[Salam, Abdul; Bosan, Altaf; Iqbal, Syma; Qureshi, Shaista Noor; Hafiz, Rehan] Natl Inst Hlth, Islamabad, Pakistan.
RP Cohen, AL (reprint author), Ctr Dis Control & Prevent, Resp Dis Branch, Div Bacterial Dis, 1600 Clifton Rd NE,MS C-23, Atlanta, GA 30333 USA.
EM alcohen1@cdc.gov
NR 20
TC 1
Z9 1
U1 0
U2 2
PU COLL PHYSICIANS & SURGEONS PAKISTAN
PI KARACHI
PA SEVENTH CENTRAL ST, DEFENCE HOUSING AUTHORITY, KARACHI, 75500, PAKISTAN
SN 1022-386X
J9 JCPSP-J COLL PHYSICI
JI JCPSP-J. Coll. Physicians Surg.
PD SEP
PY 2009
VL 19
IS 9
BP 591
EP 594
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 507OT
UT WOS:000270864700016
PM 19728950
ER
PT J
AU Potter, JE
Pereyra, M
Lampe, M
Rivero, Y
Danner, SP
Cohen, MH
Bradley-Byers, A
Webber, MP
Nesheim, SR
O'Sullivan, MJ
Jamieson, DJ
AF Potter, JoNell Efantis
Pereyra, Margaret
Lampe, Margaret
Rivero, Yvette
Danner, Susan P.
Cohen, Mardge H.
Bradley-Byers, Angela
Webber, Mayris P.
Nesheim, Steven R.
O'Sullivan, Mary Jo
Jamieson, Denise J.
TI Factors Associated With Prenatal Care Use Among Peripartum Women in the
Mother-Infant Rapid Intervention at Delivery Study
SO JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING
LA English
DT Article
DE prenatal care; access to care; perinatal outcomes; HIV testing and
pregnancy
ID LABOR
AB Objective: To evaluate factors associated with receiving prenatal care among women who present in labor without human immunodeficiency virus documentation using the results of a previous study, Mother-Infant Rapid Intervention at Delivery.
Design: Prospective, multicenter study.
Setting: Eighteen hospitals in the United States.
Participants: The present analysis is based on 667 peripartum women who completed a face-to-face interview after delivery. For purposes of this analysis, human immunodeficiency virus-infected and human immunodeficiency virus-uninfected women were considered together as the "study group."
Methods: The original study, Mother-Infant Rapid Intervention at Delivery, offered rapid human immunodeficiency virus testing to women in labor without human immunodeficiency virus testing documentation at 18 hospitals in the United States. This secondary study evaluated factors related to prenatal care, among participants who agreed to an interview after delivery.
Results: Interviews were completed by 667 women. Of these, 26.8% reported no prenatal care before admission to labor and delivery. These women were more likely to have been born in the United States, have other children, used alcohol, and reported being unhappy. Those who reported receiving prenatal care were more likely to have had Medicaid, stronger social support, and reported good health.
Conclusion: Women who are unlikely to receive prenatal care lack social support and are more likely to have additional social stressors. Medicaid may provide an important safety net to enhance access to care, because those with Medicaid were more likely to receive prenatal care. Further research is necessary to identify nontraditional models of care to enhance outreach to women at risk for no prenatal care.
C1 [Potter, JoNell Efantis; Rivero, Yvette] Univ Miami, Leonard M Miller Sch Med, Dept Obstet & Gynecol, Div Res, Miami, FL 33101 USA.
[Pereyra, Margaret] Univ Miami, Leonard M Miller Sch Med, Dept Epidemiol & Publ Hlth, Miami, FL 33101 USA.
[Nesheim, Steven R.] Ctr Dis Control & Prevent, Mother Child Transmiss Team, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA.
[Cohen, Mardge H.] Stoger Hosp, CORE Ctr, Cook Cty Bur Hlth Serv, Chicago, IL USA.
[Cohen, Mardge H.] Stoger Hosp, Dept Med, Chicago, IL USA.
[Cohen, Mardge H.] Rush Med Coll, Chicago, IL 60612 USA.
[Bradley-Byers, Angela] Louisiana State Univ, Dept Obstet & Gynecol, New Orleans, LA USA.
[Webber, Mayris P.] Montefiore Med Ctr, AIDS Res Program, Dept Epidemiol & Social Med, Bronx, NY 10467 USA.
RP Potter, JE (reprint author), Univ Miami, Leonard M Miller Sch Med, Dept Obstet & Gynecol, Div Res, POB 016960 D-53, Miami, FL 33101 USA.
EM jpotter2@med.miami.edu
FU National Center for HIV, Viral Hepatitis, STD, and TB Prevention, CDC
[U64/217724, 417719, 517715, 617734, 479935]
FX Supported by the National Center for HIV, Viral Hepatitis, STD, and TB
Prevention, CDC under cooperative agreements U64/217724, 417719, 517715,
617734, and 479935.
NR 20
TC 3
Z9 3
U1 1
U2 1
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0884-2175
J9 JOGNN-J OBST GYN NEO
JI JOGNN
PD SEP-OCT
PY 2009
VL 38
IS 5
BP 534
EP 543
DI 10.1111/j.1552-6909.2009.01049.x
PG 10
WC Nursing; Obstetrics & Gynecology
SC Nursing; Obstetrics & Gynecology
GA 498IU
UT WOS:000270133300003
PM 19883475
ER
PT J
AU Burstein, GR
Eliscu, A
Ford, K
Hogben, M
Chaffee, T
Straub, D
Shafii, T
Huppert, J
AF Burstein, Gale R.
Eliscu, Allison
Ford, Kanti
Hogben, Matthew
Chaffee, Tonya
Straub, Diane
Shafii, Taraneh
Huppert, Jill
TI Expedited Partner Therapy for Adolescents Diagnosed with Chlamydia or
Gonorrhea: A Position Paper of the Society for Adolescent Medicine
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Editorial Material
ID SEXUALLY-TRANSMITTED INFECTIONS; UNITED-STATES; TRACHOMATIS INFECTION;
NEISSERIA-GONORRHOEAE; NATIONAL-SURVEY; SEX PARTNERS; NOTIFICATION;
WOMEN; PERSISTENT; RECURRENT
C1 [Burstein, Gale R.] Erie Cty Dept Hlth, Buffalo, NY USA.
[Burstein, Gale R.] Womens & Childrens Hosp, Buffalo, NY USA.
[Eliscu, Allison] Mt Sinai Adolescent Hlth Ctr, New York, NY USA.
[Ford, Kanti; Huppert, Jill] Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH USA.
[Hogben, Matthew] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA.
[Chaffee, Tonya] San Francisco Gen Hosp, San Francisco, CA 94110 USA.
[Shafii, Taraneh] Univ Washington, Seattle, WA 98195 USA.
RP Burstein, GR (reprint author), Erie Cty Dept Hlth, Buffalo, NY USA.
EM Gale.Burstein@erie.gov
NR 36
TC 8
Z9 8
U1 2
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1054-139X
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD SEP
PY 2009
VL 45
IS 3
BP 303
EP 309
DI 10.1016/j.jadohealth.2009.05.010
PG 7
WC Psychology, Developmental; Public, Environmental & Occupational Health;
Pediatrics
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA 489JV
UT WOS:000269417300015
PM 19699429
ER
PT J
AU Hendriksen, RS
Mikoleit, M
Carlson, VP
Karlsmose, S
Vieira, AR
Jensen, AB
Seyfarth, AM
DeLong, SM
Weill, FX
Wong, DMALF
Angulo, FJ
Wegener, HC
Aarestrup, FM
AF Hendriksen, Rene S.
Mikoleit, Matthew
Carlson, Valeria P.
Karlsmose, Susanne
Vieira, Antonio R.
Jensen, Arne B.
Seyfarth, Anne Mette
DeLong, Stephanie M.
Weill, Francois-Xavier
Wong, Danilo Marino Armando Lo Fo
Angulo, Frederick J.
Wegener, Henrik C.
Aarestrup, Frank M.
TI WHO Global Salm-Surv External Quality Assurance System for Serotyping of
Salmonella Isolates from 2000 to 2007
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID UNITED-STATES; SURVEILLANCE; HUMANS
AB An international external quality assurance system (EQAS) for the serotyping of Salmonella species was initiated in 2000 by WHO Global Salm-Surv to enhance the capacity of national reference laboratories to obtain reliable data for surveillance purposes worldwide. Seven EQAS iterations were conducted between 2000 and 2007. In each iteration, participating laboratories submitted serotyping results for eight Salmonella isolates. A total of 249 laboratories in 96 countries participated in at least one EQAS iteration. A total of 756 reports were received from the participating laboratories during the seven EQAS iterations. Cumulatively, 76% of participating laboratories submitted data for all eight strains, and 82% of strains were correctly serotyped. In each iteration, 84% to 96% of the laboratories correctly serotyped the Salmonella enterica serovar Enteritidis isolate that was included as an internal quality control strain. Regional differences in performance were observed, with laboratories in Central Asia and the Middle East performing less well overall than those in other regions. Errors that resulted in incorrect serovar identification were typically caused by difficulties in the detection of the phase two flagellar antigen or in differentiation within antigen complexes; some of these errors are likely related to the quality of the antisera available. The results from the WHO Global Salm-Surv EQAS, the largest of its kind in the world, show that most laboratories worldwide are capable of correctly serotyping Salmonella species. However, this study also indicates a continuing need for improvement. Future training efforts should be aimed at enhancing the ability to detect the phase two flagellar antigen and at disseminating information on where to purchase high-quality antisera.
C1 [Hendriksen, Rene S.; Karlsmose, Susanne; Vieira, Antonio R.; Jensen, Arne B.; Seyfarth, Anne Mette; Wegener, Henrik C.; Aarestrup, Frank M.] Tech Univ Denmark, WHO Collaborating Ctr Antimicrobial Resistance Fo, Natl Food Inst, DK-1790 Copenhagen V, Denmark.
[Mikoleit, Matthew; Carlson, Valeria P.; DeLong, Stephanie M.; Angulo, Frederick J.] Ctr Dis Control & Prevent, WHO Collaborating Ctr Surveillance Epidemiol & Co, Enter Dis Epidemiol Branch, Atlanta, GA USA.
[Weill, Francois-Xavier] Inst Pasteur, WHO Collaborating Ctr Salmonella, Paris, France.
[Wong, Danilo Marino Armando Lo Fo] WHO, Dept Food Safety Zoonoses & Foodborne Dis, CH-1211 Geneva, Switzerland.
RP Hendriksen, RS (reprint author), Tech Univ Denmark, WHO Collaborating Ctr Antimicrobial Resistance Fo, Natl Food Inst, Bulowsvej 27, DK-1790 Copenhagen V, Denmark.
EM rshe@food.dtu.dk
RI Hendriksen, Rene/A-5755-2013;
OI Weill, Francois-Xavier/0000-0001-9941-5799; Wegener, Henrik
Caspar/0000-0002-6888-2121
NR 11
TC 28
Z9 29
U1 0
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD SEP
PY 2009
VL 47
IS 9
BP 2729
EP 2736
DI 10.1128/JCM.02437-08
PG 8
WC Microbiology
SC Microbiology
GA 489RL
UT WOS:000269439600006
PM 19571024
ER
PT J
AU Whitney, AM
Coulson, GB
von Gottberg, A
Block, C
Keller, N
Mayer, LW
Messonnier, NE
Klugman, KP
AF Whitney, Anne M.
Coulson, Garry B.
von Gottberg, Anne
Block, Colin
Keller, Nathan
Mayer, Leonard W.
Messonnier, Nancy E.
Klugman, Keith P.
TI Genotypic Comparison of Invasive Neisseria meningitidis Serogroup Y
Isolates from the United States, South Africa, and Israel, Isolated from
1999 through 2002
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID MENINGOCOCCAL DISEASE; MOLECULAR EPIDEMIOLOGY; POPULATIONS;
IDENTIFICATION; DIVERSITY; CLONES
AB The proportion of meningococcal disease in the United States, South Africa, and Israel caused by Neisseria meningitidis serogroup Y (NmY) was greater than the worldwide average during the period 1999-2002. Genotypic characterization of 300 NmY isolates by multilocus sequence typing, 16S rRNA gene sequencing, and PorA variable region typing was conducted to determine the relationships of the isolates from these three countries. Seventy different genotypes were found. Two groups of ST-23 clonal complex isolates accounted for 88% of the U. S. isolates, 12% of the South African isolates, and 96% of the isolates from Israel. The single common clone (ST-23/16S-19/P1.5-2,10-1) represented 57, 5, and 35% of the NmY isolates from the United States, South Africa, and Israel. The predominant clone in South Africa (ST-175/16S-21/P1.5-1,2-2), and 11 other closely related clones made up 77% of the South African study isolates and were not found among the isolates from the United States or Israel. ST-175 was the predicted founder of the ST-175 clonal complex, and isolates of ST-175 and related sequence types have been described previously in other African countries. Continued active surveillance and genetic characterization of NmY isolates causing disease in the United States, South Africa, and Israel will provide valuable data for local and global epidemiology and allow monitoring for any expansion of existing clonal complexes and detection of the emergence of new virulent clones in the population.
C1 [Whitney, Anne M.; Mayer, Leonard W.; Messonnier, Nancy E.] Ctr Dis Control & Prevent, Coordinating Ctr Infect Dis, Atlanta, GA 30333 USA.
[Coulson, Garry B.; von Gottberg, Anne; Klugman, Keith P.] Univ Witwatersrand, MRC NICD WITS Resp & Meningeal Pathogens Res Unit, MRC, Natl Inst Communicable Diseases, Johannesburg, South Africa.
[Block, Colin; Keller, Nathan] Hadassah Hebrew Univ, Med Ctr, Jerusalem, Israel.
[Block, Colin; Keller, Nathan] Chaim Sheba Med Ctr, Natl Ctr Meningococci, IL-52621 Tel Hashomer, Israel.
[Klugman, Keith P.] Emory Univ, Div Infect Dis, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Klugman, Keith P.] Emory Univ, Hubert Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
RP Whitney, AM (reprint author), Ctr Dis Control & Prevent, NCZVED DFBMD BZB SBRL, Mailstop D-11,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM awhitney@cdc.gov
NR 22
TC 9
Z9 9
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD SEP
PY 2009
VL 47
IS 9
BP 2787
EP 2793
DI 10.1128/JCM.00091-09
PG 7
WC Microbiology
SC Microbiology
GA 489RL
UT WOS:000269439600014
PM 19571028
ER
PT J
AU Morris, SR
Moore, DF
Hannah, PB
Wang, SA
Wolfe, J
Trees, DL
Bolan, G
Bauer, HM
AF Morris, Sheldon R.
Moore, Douglas F.
Hannah, Paul B.
Wang, Susan A.
Wolfe, Julia
Trees, David L.
Bolan, Gail
Bauer, Heidi M.
TI Strain Typing and Antimicrobial Resistance of Fluoroquinolone-Resistant
Neisseria gonorrhoeae Causing a California Infection Outbreak
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID FIELD GEL-ELECTROPHORESIS; DECREASED SUSCEPTIBILITY; UNITED-STATES;
RISK-FACTORS; AZITHROMYCIN; CIPROFLOXACIN; CHARACTERIZE; EPIDEMIOLOGY;
TETRACYCLINE; PREVALENCE
AB Antimicrobial-resistant Neisseria gonorrhoeae is an emerging public health problem as a result of the alarming limitation in treatment options. We examined an outbreak in California of fluoroquinolone-resistant Neisseria gonorrhoeae (QRNG) by evaluation of a combination of routine isolates from the Gonococcal Isolate Surveillance Project and isolates collected by expanded surveillance performed between April 2000 and June 2002. QRNG isolates were characterized by two methods: (i) determination of a combination of antibiogram, auxotype, serovar, Lip type, and patterns of amino acid alteration in the quinolone resistance-determining region of GyrA and ParC (ASLGP) and (ii) pulsed-field gel electrophoresis (PFGE). Strain typing was used to describe the QRNG outbreak strains and the associated antimicrobial resistance profiles. Among 79 isolates that were completely characterized, we identified 20 different ASLGP strain types, and 2 of the types were considered to belong to outbreak strains that comprised 65% (51/79) of the isolates. By PFGE typing, there were 24 different strain types, and 4 of these were considered outbreak types and comprised 66% (52/79) of the isolates. The overall agreement between the typing methods in distinguishing outbreak strains and non-outbreak strains was 84% (66/79). The most common QRNG ASLGP strain type had chromosomally mediated resistance to penicillin and tetracycline and an azithromycin MIC of 0.5 mu g/ml. The occurrence of an outbreak caused by QRNG strains that could fail to be eradicated by most antibiotic classes reinforces the serious problem with antimicrobial resistance in Neisseria gonorrhoeae that the public health system faces. Adherence to a regimen with the recommended antibiotics at the appropriate dose is critical, and monitoring for antimicrobial susceptibility needs to be actively maintained to adapt treatment guidelines appropriately.
C1 [Morris, Sheldon R.; Bolan, Gail; Bauer, Heidi M.] Calif Dept Hlth Serv, Sexually Transmitted Dis Control Branch, Richmond, CA USA.
[Moore, Douglas F.; Hannah, Paul B.; Wolfe, Julia] Orange Cty Publ Hlth Lab, Santa Ana, CA USA.
[Wang, Susan A.; Trees, David L.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Morris, SR (reprint author), Univ Calif San Diego, Antiviral Res Ctr, 150 W Washington St, San Diego, CA 92103 USA.
EM shmorris@ucsd.edu
FU CDC (Comprehensive STD Prevention Systems and Infertility Prevention
Project) [H25/CCH904362]; California Department of Health Services
FX We are grateful to the following individuals: Michael Samuel, Stewart
Coulter, Edwin Lopez, and Jessica Frasure, STD Control Branch,
California Department of Health Services; Robert Gunn, Chris Peter, Dawn
Kiefler, and Gerry Washbaugh, San Diego Health and Human Services
Agency, San Diego, CA; Penny Weismuller, Orange County Health Care
Agency; Nettie DeAugustine, Helene Calvet, and Mimi Lachica, city of
Long Beach Health and Human Services Agency, Long Beach, CA; Jeffrey
Klausner, Lynn Fischer, Virginia Lapitz, and Sally Liska, San Francisco
Department of Public Health, San Francisco, CA; Peter Kerndt, Los
Angeles County Department of Health Services, Los Angeles, CA; Franklyn
Judson and Josephine Ehret, Denver GISP Regional Laboratory, Denver, CO;
King Holmes and Wil Whittington, Seattle Regional GISP Laboratory,
University of Washington, Seattle; Ann Vanier, Kaiser Permanente
Southern California Reference Laboratories, Los Angeles; and Joan Knapp,
Susan Conner, Hillard Weinstock, Stuart Berman, and Alesia Harvey,
Division of STD Prevention, National Center for HIV, STD and TB
Prevention, CDC.
NR 36
TC 8
Z9 10
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD SEP
PY 2009
VL 47
IS 9
BP 2944
EP 2949
DI 10.1128/JCM.01001-09
PG 6
WC Microbiology
SC Microbiology
GA 489RL
UT WOS:000269439600036
PM 19625477
ER
PT J
AU Walter, J
Kuhn, L
Semrau, K
Decker, DW
Sinkala, M
Kankasa, C
Thea, DM
Bulterys, M
Ou, CY
Aldrovandi, GM
AF Walter, Jan
Kuhn, Louise
Semrau, Katherine
Decker, Don W.
Sinkala, Moses
Kankasa, Chipepo
Thea, Donald M.
Bulterys, Marc
Ou, Chin-Yih
Aldrovandi, Grace M.
TI Detection of Low Levels of Human Immunodeficiency Virus (HIV) May Be
Critical for Early Diagnosis of Pediatric HIV Infection by Use of Dried
Blood Spots
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID RESOURCE-LIMITED SETTINGS; RNA AMPLIFICATION; TYPE-1 INFECTION; DNA;
INFANTS; CHILDREN; PCR; TRANSMISSION; ASSAY
AB We compared a DNA-based assay with a total nucleic acid-based assay for early detection of infant human immunodeficiency virus (HIV) infection. The codetection of DNA and RNA did not result in an overall higher sensitivity compared to that of DNA alone. Discordant results were associated with low levels of HIV DNA, indicating that the sample amount may be critical.
C1 [Walter, Jan; Decker, Don W.; Aldrovandi, Grace M.] Univ So Calif, Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA.
[Kuhn, Louise] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA.
[Kuhn, Louise] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10027 USA.
[Semrau, Katherine; Thea, Donald M.] Boston Univ, Sch Publ Hlth, Ctr Int Hlth & Dev, Boston, MA USA.
[Sinkala, Moses] Lusaka Dist Hlth Management Team, Lusaka, Zambia.
[Kankasa, Chipepo] Univ Zambia, Univ Teaching Hosp, Lusaka, Zambia.
[Bulterys, Marc] US Ctr Dis Control & Prevent, Global AIDS Program, Lusaka, Zambia.
[Ou, Chin-Yih] Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA USA.
RP Aldrovandi, GM (reprint author), Univ So Calif, Childrens Hosp Los Angeles, 4546 Sunset Blvd Mailstop 51, Los Angeles, CA 90027 USA.
EM galdrovandi@chla.usc.edu
OI Thea, Donald/0000-0002-6933-1030; Semrau, Katherine/0000-0002-8360-1391
FU NIH [R01 HD 39611, R01 HD40777]
FX This work was supported by NIH grants (R01 HD 39611 and R01 HD40777).
G.M.A. is an Elizabeth Glaser Pediatric AIDS Foundation Scientist.
NR 18
TC 5
Z9 5
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD SEP
PY 2009
VL 47
IS 9
BP 2989
EP 2991
DI 10.1128/JCM.02453-08
PG 3
WC Microbiology
SC Microbiology
GA 489RL
UT WOS:000269439600045
PM 19625479
ER
PT J
AU Limbago, BM
Long, CM
Thompson, AD
Killgore, GE
Hannett, GE
Havill, NL
Mickelson, S
Lathrop, S
Jones, TF
Park, MM
Harriman, KH
Gould, LH
McDonald, LC
Angulo, FJ
AF Limbago, Brandi M.
Long, Cherie M.
Thompson, Angela D.
Killgore, George E.
Hannett, George E.
Havill, Nancy L.
Mickelson, Stephanie
Lathrop, Sarah
Jones, Timothy F.
Park, Mahin M.
Harriman, Kathleen H.
Gould, L. Hannah
McDonald, L. Clifford
Angulo, Frederick J.
TI Clostridium difficile Strains from Community-Associated Infections
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID RESTRICTION-ENDONUCLEASE ANALYSIS; BINARY TOXIN; FOOD ANIMALS;
TOXINOTYPES; POLYMORPHISM; EPIDEMIC; DISEASE; HUMANS
AB Clostridium difficile isolates from presumed community-associated infections (n = 92) were characterized by toxinotyping, pulsed-field gel electrophoresis, tcdC and cdtB PCR, and antimicrobial susceptibility. Nine toxinotypes (TOX) and 31 PFGE patterns were identified. TOX 0 (48, 52%), TOX III (18, 20%), and TOX V (9, 10%) were the most common; three isolates were nontoxigenic.
C1 [Limbago, Brandi M.; Thompson, Angela D.; Killgore, George E.; McDonald, L. Clifford] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
[Hannett, George E.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA.
[Long, Cherie M.] Atlanta Res & Educ Fdn, Atlanta, GA USA.
[Havill, Nancy L.] Hosp St Raphael, New Haven, CT 06511 USA.
[Mickelson, Stephanie] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA.
[Lathrop, Sarah] Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87131 USA.
[Park, Mahin M.] Georgia Publ Hlth Lab, Atlanta, GA USA.
[Jones, Timothy F.] Tennessee Dept Hlth, Nashville, TN USA.
[Harriman, Kathleen H.] Minnesota Dept Hlth, St Paul, MN USA.
[Gould, L. Hannah; Angulo, Frederick J.] Ctr Dis Control & Prevent, Div Foodborne Bacterial & Mycot Dis, Atlanta, GA USA.
RP Limbago, BM (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE,MS C-16, Atlanta, GA 30333 USA.
EM blimbago@cdc.gov
NR 22
TC 41
Z9 43
U1 0
U2 9
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD SEP
PY 2009
VL 47
IS 9
BP 3004
EP 3007
DI 10.1128/JCM.00964-09
PG 4
WC Microbiology
SC Microbiology
GA 489RL
UT WOS:000269439600050
PM 19571021
ER
PT J
AU Xiao, LH
Hlavsa, MC
Yoder, J
Ewers, C
Dearen, T
Yang, WL
Nett, R
Harris, S
Brend, SM
Harris, M
Onischuk, L
Valderrama, AL
Cosgrove, S
Xavier, K
Hall, N
Romero, S
Young, S
Johnston, SP
Arrowood, M
Roy, S
Beach, MJ
AF Xiao, Lihua
Hlavsa, Michele C.
Yoder, Jonathan
Ewers, Christina
Dearen, Theresa
Yang, Wenli
Nett, Randall
Harris, Stephanie
Brend, Sarah M.
Harris, Meghan
Onischuk, Lisa
Valderrama, Amy L.
Cosgrove, Shaun
Xavier, Karen
Hall, Nancy
Romero, Sylvia
Young, Stephen
Johnston, Stephanie P.
Arrowood, Michael
Roy, Sharon
Beach, Michael J.
TI Subtype Analysis of Cryptosporidium Specimens from Sporadic Cases in
Colorado, Idaho, New Mexico, and Iowa in 2007: Widespread Occurrence of
One Cryptosporidium hominis Subtype and Case History of an Infection
with the Cryptosporidium Horse Genotype
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID UNITED-STATES; RECREATIONAL WATER; SURVEILLANCE; SPP.; IDENTIFICATION;
DISEASE; SAMPLES; HUMANS
AB Subtyping was conducted in late 2007 on 57 Cryptosporidium specimens from sporadic cases in Colorado, Idaho, New Mexico, and Iowa. One previously rare Cryptosporidium hominis subtype was indentified in 40 cases (70%) from all four states, and the Cryptosporidium horse genotype was identified in a pet shop employee with severe clinical symptoms.
C1 [Xiao, Lihua] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, Atlanta, GA 30341 USA.
[Ewers, Christina; Onischuk, Lisa] New Mexico Dept Hlth, Santa Fe, NM 87502 USA.
[Nett, Randall] Idaho Dept Hlth & Welf, Boise, ID 83720 USA.
[Harris, Stephanie] EPA Reg, Port Orchard, WA 98366 USA.
[Brend, Sarah M.; Harris, Meghan; Hall, Nancy] Iowa Dept Publ Hlth, Des Moines, IA 50319 USA.
[Cosgrove, Shaun; Xavier, Karen] Colorado Dept Publ Hlth & Environm, Denver, CO 80246 USA.
[Young, Stephen] Tricore Reference Labs, Albuquerque, NM 87102 USA.
RP Xiao, LH (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Infect Dis, Bldg 22,Mail Stop F-12,4770 Buford Highway, Atlanta, GA 30341 USA.
EM lxiao@cdc.gov
RI Xiao, Lihua/B-1704-2013
OI Xiao, Lihua/0000-0001-8532-2727
NR 23
TC 20
Z9 21
U1 1
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD SEP
PY 2009
VL 47
IS 9
BP 3017
EP 3020
DI 10.1128/JCM.00226-09
PG 4
WC Microbiology
SC Microbiology
GA 489RL
UT WOS:000269439600054
PM 19587303
ER
PT J
AU Nix, WA
Sedmak, G
Pallansch, MA
Bhattacharyya, S
Oberste, MS
AF Nix, W. A.
Sedmak, G.
Pallansch, M. A.
Bhattacharyya, S.
Oberste, M. S.
TI Molecular characterization of human parechoviruses (HPEV) associated
with sudden infant deaths in Wisconsin
SO JOURNAL OF CLINICAL VIROLOGY
LA English
DT Meeting Abstract
CT 12th Annnual Meeting of the European-Society-for=Clinical-Virology
CY SEP 27-30, 2009
CL Istanbul, TURKEY
SP European Soc Clin Virol
C1 [Nix, W. A.; Pallansch, M. A.; Oberste, M. S.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Sedmak, G.; Bhattacharyya, S.] City Milwaukee Hlth Dept, Milwaukee, WI USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1386-6532
J9 J CLIN VIROL
JI J. Clin. Virol.
PD SEP
PY 2009
VL 46
BP S55
EP S55
PG 1
WC Virology
SC Virology
GA 504PK
UT WOS:000270629000237
ER
PT J
AU Selman, CA
AF Selman, Carol A.
TI Improving Environmental Assessments During Foodborne Outbreaks
SO JOURNAL OF ENVIRONMENTAL HEALTH
LA English
DT Editorial Material
C1 Ctr Dis Control & Prevent, Environm Hlth Serv Branch, Div Emergency & Environm Hlth Serv, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
RP Selman, CA (reprint author), Ctr Dis Control & Prevent, Environm Hlth Serv Branch, Div Emergency & Environm Hlth Serv, Natl Ctr Environm Hlth, 4770 Buford Highway NE,MS F-60, Atlanta, GA 30341 USA.
EM cselman@cdc.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATL ENVIRON HEALTH ASSOC
PI DENVER
PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA
SN 0022-0892
J9 J ENVIRON HEALTH
JI J. Environ. Health
PD SEP
PY 2009
VL 72
IS 2
BP 46
EP 47
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 489YP
UT WOS:000269463200009
PM 19761009
ER
PT J
AU Bakke, B
De Roos, AJ
Barr, DB
Stewart, PA
Blair, A
Freeman, LB
Lynch, CF
Allen, RH
Alavanja, MCR
Vermeulen, R
AF Bakke, Berit
De Roos, Anneclaire J.
Barr, Dana B.
Stewart, Patricia A.
Blair, Aaron
Freeman, Laura Beane
Lynch, Charles F.
Allen, Ruth H.
Alavanja, Michael C. R.
Vermeulen, Roel
TI Exposure to atrazine and selected non-persistent pesticides among corn
farmers during a growing season
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE exposure assessment; pesticide exposure; urine; farmers; prospective
studies
ID MASS-SPECTROMETRY; HUMAN URINE; METABOLITES
AB The aim was to develop quantitative estimates of farmers' pesticide exposure to atrazine and to provide an overview of background levels of selected nonpersistent pesticides among corn farmers in a longitudinal molecular epidemiologic study. The study population consisted of 30 Agricultural Health Study farmers from Iowa and 10 non-farming controls. Farmers completed daily and weekly diaries from March to November in 2002 and 2003 on pesticide use and other exposure determinants. Urine samples were collected at 10 time points relative to atrazine application and other farming activities. Pesticide exposure was assessed using urinary metabolites and diaries. The analytical limit of detection (LOD) ranged between 0.1 and 0.2 mu g/l for all pesticide analytes except for isazaphos (1.5 mu g/l) and diazinon (0.7 mu g/l). Farmers had higher geometric mean urinary atrazine mercapturate (AZM) values than controls during planting (1.1 vs < LOD mu g/g creatinine; P < 0.05). AZM levels among farmers were significantly related to the amount of atrazine applied (P = 0.015). Interestingly, farmers had a larger proportion of samples above the LOD than controls even after exclusion of observations with an atrazine application within 7 days before urine collection (38% vs 6%, P < 0.0001). A similar pattern was observed for 2,4-D and acetochlor (92% vs 47%, P < 0.0001 and 45% vs 4%, P < 0.0001, respectively). Urinary AZM levels in farmers were largely driven by recent application of atrazine. Therefore, the amount of atrazine applied is likely to provide valid surrogates of atrazine exposure in epidemiologic studies. Elevated background levels of non-persistent pesticides, especially 2,4-D, indicate importance in epidemiologic studies of capturing pesticide exposures that might not be directly related to the actual application. Journal of Exposure Science and Environmental Epidemiology (2009) 19, 544-554; doi:10.1038/jes.2008.53; published online 3 December 2008
C1 [Bakke, Berit; Stewart, Patricia A.; Blair, Aaron; Freeman, Laura Beane; Alavanja, Michael C. R.; Vermeulen, Roel] NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Rockville, MD 20852 USA.
[Bakke, Berit] Natl Inst Occupat Hlth, Oslo, Norway.
[De Roos, Anneclaire J.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[De Roos, Anneclaire J.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
[Barr, Dana B.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Lynch, Charles F.] Univ Iowa, Dept Epidemiol, Iowa City, IA USA.
[Allen, Ruth H.] US EPA, Washington, DC 20460 USA.
[Vermeulen, Roel] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.
[Vermeulen, Roel] Utrecht Med Ctr, Julius Ctr, Utrecht, Netherlands.
RP Alavanja, MCR (reprint author), NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, 6120 Execut Blvd,Bldg EPS 8000, Rockville, MD 20852 USA.
EM alavanjm@mail.nih.gov
RI Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013; Vermeulen,
Roel/F-8037-2011; Beane Freeman, Laura/C-4468-2015
OI Vermeulen, Roel/0000-0003-4082-8163; Beane Freeman,
Laura/0000-0003-1294-4124
FU National Institutes of Health; National Cancer Institute; Environmental
Protection Agency, USA
FX This work was supported by the Intramural Research Program of the
National Institutes of Health, National Cancer Institute and funding
from the Environmental Protection Agency, USA. We thank Cynthia J Hines
(National Institute for Occupational Health and Safety), Jane Hoppin
(National Institute of Environmental Health Sciences), and Kent Thomas
(US Environmental Protection Agency), for useful comments on an earlier
version of this article.
NR 15
TC 8
Z9 9
U1 2
U2 12
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD SEP-OCT
PY 2009
VL 19
IS 6
BP 544
EP 554
DI 10.1038/jes.2008.53
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 484VI
UT WOS:000269076100003
PM 19052531
ER
PT J
AU Faul, M
Sullivent, E
Wald, M
Xu, LK
AF Faul, Mark
Sullivent, Ernest
Wald, Marlena
Xu, Likang
TI Helicopter Emergency Medical Services Transport Is Associated With
Reduced Mortality in Injured Adults With TBI
SO JOURNAL OF HEAD TRAUMA REHABILITATION
LA English
DT Meeting Abstract
C1 [Faul, Mark; Sullivent, Ernest; Wald, Marlena; Xu, Likang] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0885-9701
J9 J HEAD TRAUMA REHAB
JI J. Head Trauma Rehabil.
PD SEP-OCT
PY 2009
VL 24
IS 5
BP 406
EP 406
PG 1
WC Clinical Neurology; Rehabilitation
SC Neurosciences & Neurology; Rehabilitation
GA 509WG
UT WOS:000271049300049
ER
PT J
AU Lockman, S
Creek, T
AF Lockman, Shahin
Creek, Tracy
TI Acute Maternal HIV Infection during Pregnancy and Breast-Feeding:
Substantial Risk to Infants
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Editorial Material
ID IMMUNODEFICIENCY-VIRUS TYPE-1; MOTHER-TO-INFANT; POSTNATAL TRANSMISSION;
PROSPECTIVE COHORT; PREVENTION; KIGALI; RWANDA; WOMEN
C1 [Lockman, Shahin] Brigham & Womens Hosp, Boston, MA 02115 USA.
[Creek, Tracy] Ctr Dis Control & Prevent, Prevent Mother Child Transmission Team, Global AIDS Program, Atlanta, GA USA.
[Lockman, Shahin] Botswana Harvard Sch Publ Hlth AIDS Initiat Partn, Gaborone, Botswana.
RP Lockman, S (reprint author), Harvard Univ, Sch Publ Hlth, FXB 401,651 Huntington Ave, Boston, MA 02115 USA.
EM slockman@hsph.harvard.edu
NR 19
TC 11
Z9 11
U1 0
U2 2
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD SEP 1
PY 2009
VL 200
IS 5
BP 667
EP 669
DI 10.1086/605124
PG 3
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 479TN
UT WOS:000268683900001
PM 19627246
ER
PT J
AU Siebenga, JJ
Vennema, H
Zheng, DP
Vinje, J
Lee, BE
Pang, XL
Ho, ECM
Lim, W
Choudekar, A
Broor, S
Halperin, T
Rasool, NBG
Hewitt, J
Greening, GE
Jin, M
Duan, ZJ
Lucero, Y
O'Ryan, M
Hoehne, M
Schreier, E
Ratcliff, RM
White, PA
Iritani, N
Reuter, G
Koopmans, M
AF Siebenga, J. Joukje
Vennema, Harry
Zheng, Du-Ping
Vinje, Jan
Lee, Bonita E.
Pang, Xiao-Li
Ho, Eric C. M.
Lim, Wilina
Choudekar, Avinash
Broor, Shobha
Halperin, Tamar
Rasool, Nassar B. G.
Hewitt, Joanne
Greening, Gail E.
Jin, Miao
Duan, Zhao-Jun
Lucero, Yalda
O'Ryan, Miguel
Hoehne, Marina
Schreier, Eckart
Ratcliff, Rodney M.
White, Peter A.
Iritani, Nobuhiro
Reuter, Gabor
Koopmans, Marion
TI Norovirus Illness Is a Global Problem: Emergence and Spread of Norovirus
GII.4 Variants, 2001-2007
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article; Proceedings Paper
CT 3rd International Calicivirus Conference
CY NOV 10-13, 2007
CL Cancun, MEXICO
ID ROUND-STRUCTURED VIRUSES; NORWALK-LIKE VIRUSES; UNITED-STATES;
GASTROENTERITIS OUTBREAKS; SPORADIC GASTROENTERITIS; MOLECULAR
EPIDEMIOLOGY; VIRAL GASTROENTERITIS; GENOGROUP-I; IDENTIFICATION;
EVOLUTION
AB Background. Noroviruses (NoVs) are the most common cause of viral gastroenteritis. Their high incidence and importance in health care facilities result in a great impact on public health. Studies from around the world describing increasing prevalence have been difficult to compare because of differing nomenclatures for variants of the dominant genotype, GII. 4. We studied the global patterns of GII. 4 epidemiology in relation to its genetic diversity.
Methods. Data from NoV outbreaks with dates of onset from January 2001 through March 2007 were collected from 15 institutions on 5 continents. Partial genome sequences (n = 775) were collected, allowing phylogenetic comparison of data from different countries.
Results. The 15 institutions reported 3098 GII. 4 outbreaks, 62% of all reported NoV outbreaks. Eight GII. 4 variants were identified. Four had a global distribution-the 1996, 2002, 2004, and 2006b variants. The 2003Asia and 2006a variants caused epidemics, but they were geographically limited. Finally, the 2001Japan and 2001Henry variants were found across the world but at low frequencies.
Conclusions. NoV epidemics resulted from the global spread of GII. 4 strains that evolved under the influence of population immunity. Lineages show notable (and currently unexplained) differences in geographic prevalence. Establishing a global NoV network by which data on strains with the potential to cause pandemics can be rapidly exchanged may lead to improved prevention and intervention strategies.
C1 [Siebenga, J. Joukje; Vennema, Harry; Koopmans, Marion] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands.
[Siebenga, J. Joukje; Koopmans, Marion] Erasmus MC, Rotterdam, Netherlands.
[Zheng, Du-Ping; Vinje, Jan] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Lee, Bonita E.; Pang, Xiao-Li] Prov Publ Hlth Lab Microbiol, Edmonton, AB, Canada.
[Ho, Eric C. M.; Lim, Wilina] Ctr Hlth Protect, Hong Kong, Hong Kong, Peoples R China.
[Jin, Miao; Duan, Zhao-Jun] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Dept Viral Diarrhea, Beijing, Peoples R China.
[Choudekar, Avinash; Broor, Shobha] All India Inst Med Sci, New Delhi, India.
[Rasool, Nassar B. G.] Univ Malaya, Kuala Lumpur, Malaysia.
[Hewitt, Joanne; Greening, Gail E.] Inst Environm Sci & Res, Porirua, New Zealand.
[Lucero, Yalda; O'Ryan, Miguel] Univ Chile, Inst Biomed Sci, Santiago, Chile.
[Hoehne, Marina; Schreier, Eckart] Robert Koch Inst, D-1000 Berlin, Germany.
[Ratcliff, Rodney M.] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA, Australia.
[Ratcliff, Rodney M.] Univ Adelaide, Inst Med & Vet Sci, Adelaide, SA, Australia.
[White, Peter A.] Univ New S Wales, Sydney, NSW, Australia.
[Iritani, Nobuhiro] Osaka City Inst Publ Hlth & Environm Sci, Osaka 543, Japan.
[Reuter, Gabor] ANTSZ Reg Inst State Publ Hlth Serv, Pecs, Hungary.
RP Siebenga, JJ (reprint author), LIS VIR, RIVM, Postbus 1, NL-3720 BA Bilthoven, Netherlands.
EM Joukje.Siebenga@RIVM.nl
RI White, Peter/C-6573-2012; O'Ryan, Miguel/H-3478-2013; Reuter,
Gabor/I-7412-2013;
OI White, Peter/0000-0002-6046-9631; O'Ryan, Miguel/0000-0002-7926-2163;
Reuter, Gabor/0000-0002-5857-4934; Vinje, Jan/0000-0002-1530-3675
NR 50
TC 333
Z9 353
U1 6
U2 64
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD SEP 1
PY 2009
VL 200
IS 5
BP 802
EP 812
DI 10.1086/605127
PG 11
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 479TN
UT WOS:000268683900019
PM 19627248
ER
PT J
AU Aburto, NJ
Ramirez-Zea, M
Neufeld, LM
Flores-Ayala, R
AF Aburto, Nancy J.
Ramirez-Zea, Manuel
Neufeld, Lynnette M.
Flores-Ayala, Rafael
TI Some Indicators of Nutritional Status Are Associated with Activity and
Exploration in Infants at Risk for Vitamin and Mineral Deficiencies
SO JOURNAL OF NUTRITION
LA English
DT Article
ID DAILY ENERGY-EXPENDITURE; MICRONUTRIENT SUPPLEMENT; UNDERNOURISHED
CHILDREN; IRON-DEFICIENCY; BEHAVIORAL-DEVELOPMENT; DIETARY INTERVENTION;
COLOMBIAN CHILDREN; PHYSICAL-ACTIVITY; MOTOR DEVELOPMENT;
CLUSTER-ANALYSIS
AB Severe malnutrition, both protein-energy and micronutrient deficiency, results in decreased activity, but the results regarding mild-to-moderate malnutrition are equivocal. Our objective in this investigation was to describe the activity and exploratory behavior of Mexican infants and describe the relationship among nutritional status, activity, and exploration in this population at high risk for mild-to-mode rate micronutrient deficiency, but at low risk for severe malnutrition. The participants were infants, 4-12 mo old, of low socioeconomic status from 3 states in southern Mexico. We measured anthropometrics using standard techniques. We measured hemoglobin (Hb) concentration in the field and adjusted values for altitude before analysis. We measured activity-and exploration by direct observation during 15 min of individual play in a novel environment. Cluster analysis generated mutually exclusive activity clusters and exploration clusters based on patterns of bodily movement and exploratory behavior, respectively. We categorized the clusters as higher or lower activity or higher or lower exploration. A higher Hb concentration and height-for-age Z-score (HAZ) significantly increased the odds of being in the high-activity cluster. Iron deficiency, stunting, and wasting significantly decreased the odds of being in the high-activity cluster. Higher HAZ and weight-for-age Z-score significantly increased the odds of being in a higher exploration cluster. In Mexican infants at risk for mild-to-moderate micronutrient deficiency but at low risk of severe malnutrition, some indicators of nutritional status were related to increased activity and exploration. J. Nutr. 139:1751-1757, 2009.
C1 [Aburto, Nancy J.; Flores-Ayala, Rafael] CDC, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA.
[Aburto, Nancy J.] Natl Inst Publ Hlth, Nutr & Hlth Res Ctr, Cuernavaca 62100, Morelos, Mexico.
[Ramirez-Zea, Manuel; Neufeld, Lynnette M.] Inst Nutr Cent Amer & Panama, Guatemala City 01011, Guatemala.
RP Aburto, NJ (reprint author), CDC, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA.
EM gdi9@cdc.gov
NR 52
TC 9
Z9 9
U1 0
U2 9
PU AMER SOC NUTRITIONAL SCIENCE
PI BETHESDA
PA 9650 ROCKVILLE PIKE, RM L-2407A, BETHESDA, MD 20814 USA
SN 0022-3166
J9 J NUTR
JI J. Nutr.
PD SEP
PY 2009
VL 139
IS 9
BP 1751
EP 1757
DI 10.3945/jn.108.100487
PG 7
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 485YV
UT WOS:000269163300021
PM 19640971
ER
PT J
AU Syamlal, G
Mazurek, JM
Bang, KM
AF Syamlal, Girija
Mazurek, Jacek M.
Bang, Ki Moon
TI Prevalence of Lifetime Asthma and Current Asthma Attacks in US Working
Adults: An Analysis of the 1997-2004 National Health Interview Survey
Data
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID OCCUPATIONAL ASTHMA; RESPIRATORY SYMPTOMS; GENERAL-POPULATION;
CIGARETTE-SMOKING; THORACIC-SOCIETY; CARE WORKERS; RISK-FACTORS;
EXPOSURE; DISEASE; WOMEN
AB Objective: To estimate national prevalences of lifetime asthma and asthma attacks among workers by age, sex, race, occupation and industry, and estimate population attributable fraction to employment for asthma attacks in the United States. Methods: The 1997-2004 National Health Interview Survey data for currently working adults aged >= 18 years were analyzed. Results: Lifetime asthma prevalence was 9.2%; the social services religious and membership organizations industry and the health service occupation had the highest asthma Prevalence. Asthma attack prevalence among workers with asthma was 35.4%; the primary metal industry and the health assessment and treating occupation had the highest attack prevalence. Approximately, 5.9% of cases reporting an asthma attack were attributed to employment when considering industries and 3.8% when considering occupations. Conclusions: Future studies and intervention strategies should address the higher prevalence of asthma in certain industries and occupations. (J Occup Environ Med. 2009;51:1066-1074)
C1 [Syamlal, Girija; Mazurek, Jacek M.; Bang, Ki Moon] NIOSH, Surveillance Branch, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
RP Syamlal, G (reprint author), NIOSH, Surveillance Branch, Div Resp Dis Studies, Ctr Dis Control & Prevent, 1095 Willowdale Rd,Mail Stop HG900-2, Morgantown, WV 26505 USA.
EM gos2@cdc.gov
NR 44
TC 12
Z9 12
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD SEP
PY 2009
VL 51
IS 9
BP 1066
EP 1074
DI 10.1097/JOM.0b013e3181b3510a
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 495MD
UT WOS:000269896200012
PM 19730397
ER
PT J
AU Eke, PI
Dye, B
AF Eke, Paul I.
Dye, Bruce
TI Assessment of Self-Report Measures for Predicting Population Prevalence
of Periodontitis
SO JOURNAL OF PERIODONTOLOGY
LA English
DT Article
DE NHANES; oral health; periodontal disease; surveillance
ID SURVEILLANCE; VALIDITY; HEALTH; QUESTIONS; DISEASE
AB Background: Self-report measures have been used successfully for the surveillance of chronic diseases in adult populations. This pilot study assessed the use of self-report oral health measures for predicting the population prevalence of periodontitis in United States adults.
Methods: Data were collected from 456 subjects participating in a 2007 study conducted by the Centers for Disease Control and Prevention. Each subject answered eight predetermined oral health self-report questions obtained from in-person interviews and were given a full-mouth periodontal examination using the National Health and Nutrition Examination Survey protocol. The predictiveness of measures from these self-report questions was assessed by multivariable logistic regression modeling measuring receiver operating characteristic (ROC) statistics, sensitivity, and specificity.
Results: Multivariable modeling incorporating self-report measures on gum disease, loose teeth, and tooth appearance alone were most useful in predicting the prevalence of severe periodontitis and improved with the addition of demographic and risk factor variables, yielding an ROC value of 0.93, sensitivity of 54.6%, and specificity of 98% at the observed 4.8% prevalence of disease. Scaling and root planing treatments, loose teeth, and the use of mouthwash, combined with demographic and risk factor covariates, were moderately useful in predicting total periodontitis.
Conclusions: Multivariable modeling of specific self-report oral health measures is promising for predicting the population prevalence of severe periodontitis, confirming earlier assessments from a national survey. These results justify further assessments of self-report oral health measures for use in the surveillance of periodontitis in the adult United States population. J Periodontol 2009;80:1371-1379.
C1 [Eke, Paul I.] Ctr Dis Control & Prevent, Div Oral Hlth, Natl Ctr Chron Dis & Hlth Promot, Atlanta, GA 30341 USA.
[Dye, Bruce] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
RP Eke, PI (reprint author), Ctr Dis Control & Prevent, Div Oral Hlth, Natl Ctr Chron Dis & Hlth Promot, Rhodes Bldg,Mail Stop F-10, Atlanta, GA 30341 USA.
EM peke@cdc.gov
FU DOH, National Center for Chronic Disease Prevention and Health
Promotion, CDC; National Center for Health Statistics, CDC; CDC
Foundation; AAP; Division of Oral Health; CDC; CDC Foundation, Atlanta,
Georgia
FX The authors acknowledge the contributions of members of the CDC-AAP
Periodontal Disease Surveillance Workgroup.2 This study was the result
of a long-term effort that benefited from support provided by leadership
of the Division of Oral Health (DOH), National Center for Chronic
Disease Prevention and Health Promotion, Coordinating Center for Health
Promotion, CDC, and the American Academy of Periodontology (AAP). In
particular, we recognize the support and contributions of Alice
DeForest, executive director, AAP, and Drs. Gordon Douglass,
RobertGenco, and Roy Page (past president of AAP and AAP representatives
in the workgroup, respectively). The funding and conduct of this study
was a collaborative effort among the DOH, National Center for Chronic
Disease Prevention and Health Promotion, CDC; the National Center for
Health Statistics, CDC; the CDC Foundation; and the AAP. This study was
funded by the Division of Oral Health, CDC, and the CDC Foundation,
Atlanta, Georgia. The authors report no financial relationship related
to any products involved in this study. The findings and conclusions in
this report are those of the authors and do not necessarily represent
the official position of the Centers for Disease Control and Prevention.
NR 14
TC 28
Z9 28
U1 0
U2 1
PU AMER ACAD PERIODONTOLOGY
PI CHICAGO
PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 USA
SN 0022-3492
J9 J PERIODONTOL
JI J. Periodont.
PD SEP
PY 2009
VL 80
IS 9
BP 1371
EP 1379
DI 10.1902/jop.2009.080607
PG 9
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 497XM
UT WOS:000270098300001
PM 19722785
ER
PT J
AU Bauman, A
Ainsworth, BE
Bull, F
Craig, CL
Hagstromer, M
Sallis, JF
Pratt, M
Sjostrom, M
AF Bauman, Adrian
Ainsworth, Barbara E.
Bull, Fiona
Craig, Cora L.
Hagstromer, Maria
Sallis, James F.
Pratt, Michael
Sjostrom, Michael
TI Progress and Pitfalls in the Use of the International Physical Activity
Questionnaire (IPAQ) for Adult Physical Activity Surveillance
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Editorial Material
ID QUALITY-OF-LIFE; POPULATION; HEALTH; SAMPLE; INACTIVITY; VALIDITY
C1 [Bauman, Adrian] Univ Sydney, Ctr Phys Act & Hlth, Sch Publ Hlth, Sydney, NSW 2006, Australia.
[Ainsworth, Barbara E.] Arizona State Univ, Healthy Lifestyles Res Ctr, Mesa, AZ USA.
[Ainsworth, Barbara E.] Arizona State Univ, Program Exercise & Wellness, Coll Nursing & Hlth Innovat, Mesa, AZ USA.
[Bull, Fiona] Univ Loughborough, Sch Sport & Exercise Sci, Loughborough, Leics, England.
[Bull, Fiona] Univ Western Australia, Sch Populat Hlth, Nedlands, WA 6009, Australia.
[Craig, Cora L.] Canadian Fitness & Lifestyle Res Inst, Ottawa, ON, Canada.
[Hagstromer, Maria; Sjostrom, Michael] Karolinska Inst, Dept Biosci & Nutr Novum, Stockholm, Sweden.
[Sallis, James F.] San Diego State Univ, San Diego, CA 92182 USA.
[Pratt, Michael] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
RP Bauman, A (reprint author), Univ Sydney, Ctr Phys Act & Hlth, Sch Publ Hlth, Sydney, NSW 2006, Australia.
RI Bull, Fiona/G-4148-2012
NR 32
TC 50
Z9 50
U1 2
U2 15
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD SEP
PY 2009
VL 6
SU 1
BP S5
EP S8
PG 4
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 664AO
UT WOS:000282931500003
PM 19998844
ER
PT J
AU Carlson, SA
Densmore, D
Fulton, JE
Yore, MM
Kohl, HW
AF Carlson, Susan A.
Densmore, Dianna
Fulton, Janet E.
Yore, Michelle M.
Kohl, Harold W., III
TI Differences in Physical Activity Prevalence and Trends From 3 U.S.
Surveillance Systems: NHIS, NHANES, and BRFSS
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Article
DE health behavior; questionnaires; Healthy People 2010; adults
ID UNITED-STATES; TELEPHONE; HEALTH
AB Background: Three U.S. surveillance systems-National Health Interview Survey (NHIS), National Health and Nutrition Examination Survey (NHANES), and Behavioral Risk Factor Surveillance System (BRFSS)-estimate physical activity prevalence. Methods: Survey differences were examined qualitatively. Prevalence estimates by sex, age, and race/ethnicity were assessed for comparable survey periods. Trends were examined from NHIS 1998 to 2007, NHANES 1999 to 2006, and BRFSS 2001 to 2007. Results: Age-adjusted prevalence estimates appeared most similar for NHIS 2005 (physically active: 30.2%, inactive: 40.7%) and NHANES 2005 to 2006 (physically active: 33.5%, inactive: 32.4%). In BRFSS 2005, prevalence of being physically active was 48.3% and inactive was 13.9%. Across all systems, men were more likely to be active than women; non-Hispanic whites were most likely to be active; as age increased, overall prevalence of being active decreased. Prevalence of being active exhibited a significant increasing trend only in BRFSS 2001 to 2007 (P <.001), while prevalence of being inactive decreased significantly in NHANES 1999 to 2006 (P <.001) and BRFSS 2001 to 2007 (P <.001). Conclusions: Different ways of assessing physical activity in surveillance systems result in different prevalence estimates. Before comparing estimates from different systems, all aspects of data collection and data analysis should be examined to determine if comparisons are appropriate.
C1 [Carlson, Susan A.; Densmore, Dianna; Fulton, Janet E.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30333 USA.
[Yore, Michelle M.] Orlando Epidemiol, Orlando, FL USA.
[Kohl, Harold W., III] Univ Texas Sch Publ Hlth, Div Epidemiol, Austin, TX USA.
RP Carlson, SA (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30333 USA.
NR 23
TC 56
Z9 58
U1 0
U2 6
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD SEP
PY 2009
VL 6
SU 1
BP S18
EP S27
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 664AO
UT WOS:000282931500005
PM 19998846
ER
PT J
AU Fulton, JE
Wang, XW
Yore, MM
Carlson, SA
Galuska, DA
Caspersen, CJ
AF Fulton, Janet E.
Wang, Xuewen
Yore, Michelle M.
Carlson, Susan A.
Galuska, Deborah A.
Caspersen, Carl J.
TI Television Viewing, Computer Use, and BMI Among U.S. Children and
Adolescents
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Article
DE exercise; physical activity; sedentary behavior; objectives;
recommendations
ID NUTRITION EXAMINATION SURVEY; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE;
NATIONAL-HEALTH; UNITED-STATES; OBESITY; ETHNICITY; YOUTH; MEDIA;
INTERVENTION
AB Background: To examine the prevalence of television (TV) viewing, computer use, and their combination and associations with demographic characteristics and body mass index (BMI) among U.S. youth. Methods: The 1999 to 2006 National Health and Nutrition Examination Survey (NHANES) was used. Time spent yesterday sitting and watching television or videos (TV viewing) and using the computer or playing computer games (computer use) were assessed by questionnaire. Results: Prevalence (%) of meeting the U.S. objective for TV viewing (<= 2 hours/day) ranged from 65% to 71%. Prevalence of no computer use (0 hours/day) ranged from 23% to 45%. Non-Hispanic Black youth aged 2 to 15 years were less likely than their non-Hispanic White counterparts to meet the objective for TV viewing. Overweight or obese school-age youth were less likely than their normal weight counterparts to meet the objective for TV viewing Conclusions: Computer use is prevalent among U.S. youth; more than half of youth used a computer on the previous day. The proportion of youth meeting the U.S. objective for TV viewing is less than the target of 75%. Time spent in sedentary behaviors such as viewing TV may contribute to overweight and obesity among U.S. youth.
C1 [Fulton, Janet E.; Yore, Michelle M.; Carlson, Susan A.; Galuska, Deborah A.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30333 USA.
[Wang, Xuewen] Washington Univ, Sch Med, Div Geriatr & Nutr Sci, St Louis, MO USA.
[Caspersen, Carl J.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA.
RP Fulton, JE (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30333 USA.
RI Caspersen, Carl/B-2494-2009
NR 34
TC 42
Z9 48
U1 2
U2 8
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD SEP
PY 2009
VL 6
SU 1
BP S28
EP S35
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 664AO
UT WOS:000282931500006
PM 19998847
ER
PT J
AU Galuska, DA
Fulton, JE
AF Galuska, Deborah A.
Fulton, Janet E.
TI Physical Activity Surveillance: Providing Public Health Data for
Decision Makers
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Editorial Material
ID UNITED-STATES
C1 [Galuska, Deborah A.; Fulton, Janet E.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
RP Galuska, DA (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
NR 12
TC 2
Z9 2
U1 0
U2 1
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD SEP
PY 2009
VL 6
SU 1
BP S1
EP S2
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 664AO
UT WOS:000282931500001
PM 19998842
ER
PT J
AU Loustalot, F
Carlson, SA
Fulton, JE
Kruger, J
Galuska, DA
Lobelo, F
AF Loustalot, Fleetwood
Carlson, Susan A.
Fulton, Janet E.
Kruger, Judy
Galuska, Deborah A.
Lobelo, Felipe
TI Prevalence of Self-Reported Aerobic Physical Activity Among U.S. States
and Territories-Behavioral Risk Factor Surveillance System, 2007
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Article
DE 2008 Physical Activity Guidelines for Americans; Healthy People 2010;
Centers for Disease Control and Prevention
ID UNITED-STATES
AB Background: Accurate surveillance data on physical activity prevalence is important for U.S. states and territories as they develop programs and interventions to increase physical activity participation. Methods: Using 2007 data from the Behavioral Risk Factor Surveillance System, we estimated the percentage of U.S. adults in each U.S. state and territory who met minimum aerobic activity criteria using the 2008 Physical Activity Guidelines for Americans (2008 Guidelines) and the Healthy People 2010 criteria for physical activity. SUDAAN was used to calculate prevalence estimates and 95% confidence intervals. Results: The estimated prevalence of recommended aerobic activity in U.S. states and territories ranged from 44.5% to 73.3% according to 2008 Guidelines and from 30.8% to 60.0% according to Healthy People 2010 criteria. Absolute percent differences in prevalence among U.S. states and territories ranged from 11.7% to 19.1%, and relative percent differences ranged from 20.8% to 44.6%. Conclusions: In all U.S. states and territories, a larger proportion of U.S. adults met minimum aerobic activity criteria in the 2008 Guidelines than met corresponding criteria in Healthy People 2010. This difference, however, does not reflect an actual change in the amount of aerobic activity, but a change to the criteria for meeting 2008 Guidelines.
C1 [Loustalot, Fleetwood; Carlson, Susan A.; Fulton, Janet E.; Kruger, Judy; Galuska, Deborah A.; Lobelo, Felipe] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30333 USA.
RP Loustalot, F (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30333 USA.
RI lobelo, felipe/B-9148-2013
NR 27
TC 14
Z9 14
U1 0
U2 1
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD SEP
PY 2009
VL 6
SU 1
BP S9
EP S17
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 664AO
UT WOS:000282931500004
PM 19998845
ER
PT J
AU Lowry, R
Lee, SM
Fulton, JE
Kann, L
AF Lowry, Richard
Lee, Sarah M.
Fulton, Janet E.
Kann, Laura
TI Healthy People 2010 Objectives for Physical Activity, Physical
Education, and Television Viewing Among Adolescents: National Trends
From the Youth Risk Behavior Surveillance System, 1999-2007
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Article
DE exercise; sedentary; behaviors; students
ID US CHILDREN; OVERWEIGHT; OBESITY
AB Background: To help inform policies and programs, a need exists to understand the extent to which Healthy People 2010 objectives for physical activity, physical education (PE), and television (TV) viewing among adolescents are being achieved. Methods: As part of the Youth Risk Behavior Surveillance System, 5 national school-based surveys were conducted biennially from 1999 through 2007. Each survey used a 3-stage cross-sectional sample of students in grades 9 to 12 and provided self-reported data from approximately 14,000 students. Logistic regression models that controlled for sex, race/ethnicity, and grade were used to analyze secular trends. Results: During 1999 to 2007, prevalence estimates for regular participation in moderate and vigorous physical activity, participation in daily PE classes, and being physically active in PE classes did not change significantly among female, male, white, black, or Hispanic students. In contrast, the prevalence of TV viewing for 2 or fewer hours on a school day increased significantly among female, male, white, black, and Hispanic students and among students in every grade except 12th grade. Conclusions: Among US adolescents, no significant progress has been made toward increasing participation in physical activity or school PE classes; however, improvements have been made in reducing TV viewing time.
C1 [Lowry, Richard; Lee, Sarah M.; Kann, Laura] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA 30333 USA.
[Fulton, Janet E.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA.
RP Lowry, R (reprint author), Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA 30333 USA.
NR 32
TC 17
Z9 19
U1 1
U2 6
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD SEP
PY 2009
VL 6
SU 1
BP S36
EP S45
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 664AO
UT WOS:000282931500007
PM 19998848
ER
PT J
AU Pratt, M
Fulton, JE
AF Pratt, Michael
Fulton, Janet E.
TI Staying on Task: Challenges of Global Physical Activity Surveillance
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Editorial Material
ID PUBLIC-HEALTH
C1 [Pratt, Michael; Fulton, Janet E.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
RP Pratt, M (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
NR 9
TC 0
Z9 0
U1 0
U2 0
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD SEP
PY 2009
VL 6
SU 1
BP S3
EP S4
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 664AO
UT WOS:000282931500002
PM 19998843
ER
PT J
AU Walker, JT
Mowen, AJ
Hendricks, WW
Kruger, J
Morrow, JR
Bricker, K
AF Walker, Joseph T.
Mowen, Andrew J.
Hendricks, William W.
Kruger, Judy
Morrow, James R., Jr.
Bricker, Kelly
TI Physical Activity in the Park Setting (PA-PS) Questionnaire: Reliability
in a California Statewide Sample
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Article
DE surveillance; recreation; exercise; health
ID AGREEMENT
AB Background: The Physical Activity in Parks Setting (PA-PS) instrument is a series of survey questions designed by a consortium of public health and leisure research scholars to gauge park-based physical activity for use in civilian, noninstitutionalized populations. This paper introduces this self-reported instrument and provides test-retest reliability results. Methods: Data to test the instrument reliability were collected during 2 waves in 2008 through the California Outdoor Recreation Opinions and Attitudes Telephone Survey. To conduct test-retest reliability we examined the agreement between 100 randomly reselected respondents from the first wave of respondents (n = 2004) that answered the same survey within 21 to 30 days of the initial administration. Results: The reliability of measures that categorized individual park use and visitation with others provided moderate levels of agreement (Kappa = 0.44 to 0.64). Questions about park features, facilities and amenity use, and specific park-based physical activity participation were of fair to substantial agreement (Kappa = 0.21 to 0.90) depending on the item in question. Conclusion: The results from these test-retest reliability analyses suggest the PA-PS items were reliable and should be considered in future population surveys that assess park visitation patterns and park-based physical activity levels.
C1 [Walker, Joseph T.; Morrow, James R., Jr.] Univ N Texas, Dept Kinesiol Hlth Promot Recreat, Denton, TX 76203 USA.
[Mowen, Andrew J.] Penn State Univ, Dept Recreat Pk & Tourism Management, State Coll, PA USA.
[Hendricks, William W.] Calif Polytech State Univ San Luis Obispo, Dept Recreat Parks & Tourism Adm, San Luis Obispo, CA 93407 USA.
[Kruger, Judy] Ctr Dis Control, Phys Act & Hlth Branch, Atlanta, GA 30333 USA.
[Bricker, Kelly] Univ Utah, Dept Parks Recreat & Tourism, Salt Lake City, UT USA.
RP Walker, JT (reprint author), Univ N Texas, Dept Kinesiol Hlth Promot Recreat, Denton, TX 76203 USA.
NR 26
TC 8
Z9 8
U1 1
U2 4
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD SEP
PY 2009
VL 6
SU 1
BP S97
EP S104
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 664AO
UT WOS:000282931500014
PM 19998855
ER
PT J
AU Ervin, RB
Dye, BA
AF Ervin, R. Bethene
Dye, Bruce A.
TI The Effect of Functional Dentition on Healthy Eating Index Scores and
Nutrient Intakes in a Nationally Representative Sample of Older Adults
SO JOURNAL OF PUBLIC HEALTH DENTISTRY
LA English
DT Article
DE NHANES; Healthy Eating Index (HEI); nutrients; dentate status;
carotenes; elderly
ID NUTRITIONAL-STATUS; ORAL-HEALTH; US ADULTS; GENDER-DIFFERENCES; DIET
QUALITY; FOOD; PEOPLE; TEETH
AB Objective: The objectives of this study were to examine the associations between functional dentition and the Healthy Eating Index (HEI) scores and nutrient intakes among older adults in the United States. Methods: The sample consisted of 2,560 adults, 60 years and over from the National Health and Nutrition Examination Survey 1999-2002. We used multivariate linear regression to examine associations between functional dentition and HEI scores or nutrient intakes controlling for the potential confounding effects of age, race/ethnicity, education, smoking status, body mass index (BMI), self-reported health, and caloric intake. Dentate status was classified as: edentulous (no natural permanent teeth or implants), 1-20 teeth, or >= 21 teeth. A functional dentition was defined as having 21 or more teeth present. HEI scores and nutrient intakes were based on one 24-hour dietary recall. Results: Males with a functional dentition consumed slightly more fruit and had higher alpha- and beta-carotene intakes than edentulous males. Females with any natural teeth had higher vitamin C intakes than edentulous females. There were no significant associations between dentate status and any of the remaining HEI scores or nutrient intakes for either sex. Conclusions: Having a functional dentition did not contribute substantially to higher HEI scores or nutrient intakes in this nationally representative sample of older adults. However, older men and women with no teeth or those who wear dentures consumed fewer servings of fruits and vegetables, especially those rich in carotenes and vitamin C, than those with teeth.
C1 [Ervin, R. Bethene; Dye, Bruce A.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Hlth Examinat Stat, Hyattsville, MD 20782 USA.
[Ervin, R. Bethene; Dye, Bruce A.] CDC, Natl Ctr Hlth Stat, Div Hlth & Nutr Examinat Stat, Hyattsville, MD USA.
RP Ervin, RB (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Hlth Examinat Stat, 3311 Toledo Rd,Rm 4420, Hyattsville, MD 20782 USA.
EM rbe0@cdc.gov
NR 31
TC 21
Z9 21
U1 1
U2 11
PU AAPHD NATIONAL OFFICE
PI PORTLAND
PA 3760 SW LYLE COURT, PORTLAND, OR 97221 USA
SN 0022-4006
J9 J PUBLIC HEALTH DENT
JI J. Public Health Dent.
PD FAL
PY 2009
VL 69
IS 4
BP 207
EP 216
DI 10.1111/j.1752-7325.2009.00124.x
PG 10
WC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational
Health
SC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational
Health
GA 528KD
UT WOS:000272442300001
PM 19453869
ER
PT J
AU Brown, DW
AF Brown, David W.
TI Complete Edentulism Prior to the Age of 65 Years is Associated with
All-Cause Mortality
SO JOURNAL OF PUBLIC HEALTH DENTISTRY
LA English
DT Article
DE tooth loss; mortality; cohort studies
ID NATIONAL DEATH INDEX; CORONARY-HEART-DISEASE; TOOTH LOSS; ORAL-HEALTH;
FOLLOW-UP; PERIODONTAL-DISEASE; RISK-FACTORS; VALIDITY; TEETH; WOMEN
AB Purpose: We examine the relationship between complete edentulism prior to the age of 65 years and all-cause mortality after adjustment for socioeconomic characteristics. Methods: Using data from 41,000 adult participants in the 1986 National Health Interview Survey, with mortality follow-up data on each cohort member through December 31, 2002 (16 years follow-up), we estimated the relative odds of all-cause mortality among adults (age >= 18 years) with complete edentulism prior to the age of 65 years compared with that among those without the condition. Multivariable-adjusted logistic regression analyses were repeated for complete edentulism at any age. Results: The age-standardized prevalence of complete edentulism was 12.3 percent [95 percent confidence interval (CI), 12.0-12.6]. Among persons aged < 65 years, the risk of death from all causes was 19 percent for persons with complete edentulism compared to 10 percent for persons without. Compared with those without complete tooth loss, the risk of death from all causes was 1.5 (95 percent CI, 1.3-1.7) (P < 0.001) times greater for persons with complete edentulism prior to the age of 65 years after multivariable adjustment. Similar results were observed for complete edentulism among persons aged >= 65 years. Conclusions: Complete edentulism prior to the age of 65 years was associated with all-cause mortality after multivariable adjustment for several socioeconomic characteristics. These results provide further evidence supporting the notion that poor oral health as evidenced by complete edentulism is an important public health issue across the lifespan.
C1 Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
RP Brown, DW (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE MS K67, Atlanta, GA 30341 USA.
EM dbrown6@cdc.gov
NR 36
TC 18
Z9 18
U1 1
U2 4
PU AAPHD NATIONAL OFFICE
PI PORTLAND
PA 3760 SW LYLE COURT, PORTLAND, OR 97221 USA
SN 0022-4006
J9 J PUBLIC HEALTH DENT
JI J. Public Health Dent.
PD FAL
PY 2009
VL 69
IS 4
BP 260
EP 266
DI 10.1111/j.1752-7325.2009.00132.x
PG 7
WC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational
Health
SC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational
Health
GA 528KD
UT WOS:000272442300008
PM 19453862
ER
PT J
AU Pazol, K
Prill, MM
Gazmararian, JA
O'Malley, EM
Jelks, D
Coleman, MS
Hinman, AR
Orenstein, WA
AF Pazol, Karen
Prill, Mila M.
Gazmararian, Julie A.
O'Malley, Emily M.
Jelks, Deborah
Coleman, Margaret S.
Hinman, Alan R.
Orenstein, Walter A.
TI Support for Universal Childhood Vaccination Against Influenza Among
Private Pediatric Clinics and Public Health Departments in Georgia
SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE
LA English
DT Article
DE Advisory Committee on Immunization Practices; influenza; school
vaccination programs; universal vaccination
ID CHRONIC MEDICAL CONDITIONS; PRIMARY-CARE PRACTICES; UNITED-STATES;
IMMUNIZATION PRACTICES; HEPATITIS-B; CHILDREN; SCHOOLCHILDREN;
ADOLESCENTS; VISITS; HOSPITALIZATIONS
AB Recently, it has been recommended that all persons 6 months to 18 years be vaccinated annually against influenza, To assess support for this universal recommendation leading up to its implementation, a cross-sectional survey of healthcare workers at private pediatric clinics (N = 44) and public health departments (N = 75) was conducted. The survey, conducted in the state of Georgia during 2005-2006, asked about (a) support for universal childhood vaccination against influenza, (b) general and influenza-specific immunization practices in 2004-2005, and (c) types of assistance needed to implement a universal childhood recommendation. Our response rate was 70 percent for private clinics and 71 percent for public health departments. The majority of providers supported universal childhood vaccination against influenza; agreement was especially pronounced at public health departments. Public health departments employed more nurses and were more likely to have a policy of vaccinating parents along with their children; private clinics were more likely to use patient reminders or add extra hours during the influenza vaccination season. Respondents from both types of clinics indicated they would need multiple forms of assistance to implement a universal recommendation for childhood vaccination against influenza. Given the strong support for universal vaccination among healthcare workers at public health departments, these facilities may be instrumental for reaching the large number of children recently added to the recommendations. However, these facilities will need multiple forms of assistance.
C1 [Pazol, Karen] Emory Univ, Sch Med, Emory Vaccine Ctr, Div Infect Dis, Atlanta, GA 30322 USA.
[Prill, Mila M.] P3S Corp, Atlanta, GA USA.
[Prill, Mila M.; Coleman, Margaret S.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Gazmararian, Julie A.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[O'Malley, Emily M.] UCB Inc, Smyrna, GA USA.
[Jelks, Deborah] Georgia Dept Human Resources, Div Publ Hlth, Immunizat Program, Atlanta, GA USA.
[Hinman, Alan R.] Task Force Global Hlth, Decatur, GA USA.
[Orenstein, Walter A.] Bill & Melinda Gates Fdn, Global Hlth Program, Seattle, WA USA.
RP Pazol, K (reprint author), Emory Univ, Sch Med, Emory Vaccine Ctr, Div Infect Dis, Room 446,Dent Bldg,1462 Clifton Rd NE, Atlanta, GA 30322 USA.
EM kpazol@emory.edu
FU NCRR NIH HHS [1P20RR020735]
NR 49
TC 0
Z9 0
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1078-4659
J9 J PUBLIC HEALTH MAN
JI J. Public Health Manag. Pract.
PD SEP-OCT
PY 2009
VL 15
IS 5
BP 393
EP 400
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 485OV
UT WOS:000269134000004
PM 19704307
ER
PT J
AU Nelson, AE
Braga, L
Braga-Baiak, A
Atashili, J
Schwartz, TA
Renner, JB
Helmick, CG
Jordan, JM
AF Nelson, Amanda E.
Braga, Larissa
Braga-Baiak, Andresa
Atashili, Julius
Schwartz, Todd A.
Renner, Jordan B.
Helmick, Charles G.
Jordan, Joanne M.
TI Static Knee Alignment Measurements among Caucasians and African
Americans: The Johnston County Osteoarthritis Project
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE KNEE OSTEOARTHRITIS; RACIAL DIFFERENCES; KNEE ALIGNMENT
ID PROGRESSION; PREVALENCE; CHINESE; VALGUS; VARUS
AB Objective. To determine if knee alignment measures differ between African Americans and Caucasians without radiographic knee osteoarthritis (rOA).
Methods. A single knee was randomly selected from 175 participants in the Johnston County Osteoarthritis Project without rOA in either knee. Anatomic axis, condylar, tibia] plateau, and condylar plateau angles were measured by I radiologist; means were compared and adjusted for age and body mass index (BMI).
Results. There were no significant differences in knee alignment measurements between Caucasians and African Americans among men or women.
Conclusion. Observed differences in knee rOA occurrence between African Americans and Caucasians are not explained by differences in static knee alignment. (First Release July 15 2009; J Rheumatol 2009;36:1987-90; doi: 10.3899/jrheum.081294)
C1 [Nelson, Amanda E.] Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC 27599 USA.
Univ Nebraska, Dept Radiol, Omaha, NE 68182 USA.
Univ Sao Paulo, Sao Paulo, Brazil.
Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA.
Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA.
Univ N Carolina, Dept Radiol, Chapel Hill, NC 27599 USA.
Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Nelson, AE (reprint author), Univ N Carolina, Thurston Arthrit Res Ctr, 3300 Thurston Bldg,CB 7280, Chapel Hill, NC 27599 USA.
EM AENelson@unch.unc.edu
RI Schwartz, Todd/D-4995-2012
OI Schwartz, Todd/0000-0002-0232-2543
FU NIAMS NIH HHS [T32 AR007416, T32 AR007416-26, T-32-AR007416]; PHS HHS
[S3486, S043]
NR 13
TC 5
Z9 5
U1 0
U2 0
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 920 YONGE ST, SUITE 115, TORONTO, ONTARIO M4W 3C7, CANADA
SN 0315-162X
J9 J RHEUMATOL
JI J. Rheumatol.
PD SEP
PY 2009
VL 36
IS 9
BP 1987
EP 1990
DI 10.3899/jrheum.081294
PG 4
WC Rheumatology
SC Rheumatology
GA 492RT
UT WOS:000269677600026
PM 19605676
ER
PT J
AU Hess, R
Avis, N
Chang, YF
Thurston, R
Bromberger, J
Greendale, G
Randolph, J
Cain, V
Dye, C
Clark, M
Matthews, K
AF Hess, Rachel
Avis, Nancy
Chang, Yuefang
Thurston, Rebecca
Bromberger, Joyce
Greendale, Gail
Randolph, John
Cain, Virginia
Dye, Claire
Clark, Margaret
Matthews, Karen
TI RELATIONSHIP QUALITY IS ASSOCIATED WITH SEXUAL FUNCTIONING IN MIDLIFE
WOMEN: RESULTS FROM THE STUDY OF WOMEN'S HEALTH ACROSS THE NATION
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Meeting Abstract
C1 [Bromberger, Joyce] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA.
[Avis, Nancy] Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA.
[Greendale, Gail; Dye, Claire] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
[Randolph, John] Univ Michigan, Sch Med, Ann Arbor, MI USA.
[Cain, Virginia] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
[Clark, Margaret] Yale Univ, New Haven, CT USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1743-6095
J9 J SEX MED
JI J. Sex. Med.
PD SEP
PY 2009
VL 6
BP 370
EP 370
PG 1
WC Urology & Nephrology
SC Urology & Nephrology
GA 490MO
UT WOS:000269505300015
ER
PT J
AU Bernhardt, JM
Usdan, S
Mays, D
Martin, R
Cremeens, J
Arriola, KJ
AF Bernhardt, Jay M.
Usdan, Stuart
Mays, Darren
Martin, Ryan
Cremeens, Jennifer
Arriola, Kimberly Jacob
TI Alcohol Assessment Among College Students Using Wireless Mobile
Technology
SO JOURNAL OF STUDIES ON ALCOHOL AND DRUGS
LA English
DT Article
ID TIMELINE FOLLOW-BACK; HAND-HELD COMPUTERS; DRINKING PATTERNS;
CONSUMPTION; RELIABILITY; CONSEQUENCES; INTERVIEWS; TELEPHONE; VALIDITY
AB Objective: This study used a two-group randomized design to assess the validity of measuring self-reported alcohol consumption among college students using the Handheld Assisted Network Diary (HAND), a daily diary assessment administered using wireless mobile devices. Method: A convenience sample of college students was recruited at a large, public university in the southeastern United States and randomized into two groups. A randomly assigned group of 86 students completed the daily HAND assessment during the 30-day study and a Timeline Followback (TLFB) at 30-day follow-up. A randomly assigned group of 82 Students completed the paper-and-pencil Daily Social Diary (DSD) over the same study period. Data from the daily HAND assessment were compared with the TLFB completed at follow-up by participants who completed the HAND using 95% limits of agreement analysis. Furthermore, individual growth model,, were used to examine differences between the HAND and DSD by comparing the total drinks, drinking clays, and drinks per drinking day captured by the two assessments over the study period. Results: Results suggest that the HAND captured similar levels of alcohol use compared with the TLFB completed at follow-up by the same participants. In addition, comparisons of the two study groups suggest that, controlling for baseline alcohol use and demographics, the HAND assessment captured similar levels of total drinks, drinking days, and drinks per drinking day as, the paper-and-pencil DSD. Conclusions: The study findings support the validity of wireless mobile devices as a daily assessment of alcohol use among college students. (J. Stud. Alcohol Drugs 70: 771-775, 2009)
C1 [Bernhardt, Jay M.; Usdan, Stuart; Mays, Darren; Martin, Ryan; Cremeens, Jennifer; Arriola, Kimberly Jacob] Ctr Dis Control & Prevent, Natl Ctr Hlth Mkt, Atlanta, GA 30329 USA.
RP Bernhardt, JM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Mkt, 1600 Clifton Rd NE,MS E21, Atlanta, GA 30329 USA.
EM jbernhardt@cdc.gov
OI Bernhardt, Jay/0000-0002-2045-4005
FU National Institute on Alcohol Abuse and Alcoholism [5R21AA013969-03];
Research Participation Program for the Centers for Disease Control and
Prevention (CDC); Oak Ridge Institute for Science and Education through
an agreement between the Department of Energy and the CDC (Darren Mays);
U.S. Department of Health and Human Services or the Centers for Disease
Control and Prevention
FX This research was supported by National Institute on Alcohol Abuse and
Alcoholism grant 5R21AA013969-03. The preparation of this manuscript was
Supported in part by an appointment to the Research Participation
Program for the Centers for Disease Control and Prevention (CDC)
administered by the Oak Ridge Institute for Science and Education
through an agreement between the Department of Energy and the CDC
(Darren Mays). The findings and conclusions in this article are those of
the authors and do not necessarily represent the views of the U.S.
Department of Health and Human Services or the Centers for Disease
Control and Prevention.
NR 23
TC 17
Z9 17
U1 0
U2 1
PU ALCOHOL RES DOCUMENTATION INC CENT ALCOHOL STUD RUTGERS UNIV
PI PISCATAWAY
PA C/O DEIRDRE ENGLISH, 607 ALLISON RD, PISCATAWAY, NJ 08854-8001 USA
SN 1937-1888
EI 1938-4114
J9 J STUD ALCOHOL DRUGS
JI J. Stud. Alcohol Drugs
PD SEP
PY 2009
VL 70
IS 5
BP 771
EP 775
PG 5
WC Substance Abuse; Psychology
SC Substance Abuse; Psychology
GA 496MY
UT WOS:000269979800016
PM 19737502
ER
PT J
AU Keckler, M
Gallardo-Romero, NF
Langham, G
Carroll, DS
Karem, KL
Damon, IK
AF Keckler, M.
Gallardo-Romero, N. F.
Langham, G.
Carroll, D. S.
Karem, K. L.
Damon, I. K.
TI Physiologic Reference Ranges for Age-Matched, Wild Caught Black-Tailed
Prairie Dogs (Cynomys ludovicianus)
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Meeting Abstract
C1 [Keckler, M.; Gallardo-Romero, N. F.; Carroll, D. S.; Karem, K. L.; Damon, I. K.] Ctr Dis Control & Prevent, NCZVED, DVRD, PRB, Lawrenceville, NJ USA.
[Langham, G.] Ctr Dis Control & Prevent, NCPDCID, DSR, ARB, Lawrenceville, NJ USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD SEP
PY 2009
VL 48
IS 5
BP 627
EP 627
PG 1
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 502SI
UT WOS:000270480000322
ER
PT J
AU Cleveland, JL
Robison, VA
Panlilio, AL
AF Cleveland, Jennifer L.
Robison, Valerie A.
Panlilio, Adelisa L.
TI Tuberculosis epidemiology, diagnosis and infection control
recommendations for dental settings An update on the Centers for Disease
Control and Prevention guidelines
SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
LA English
DT Article
DE Tuberculosis; epidemiology; diagnosis; dentistry; infection control;
guidelines
ID UNITED-STATES; MASKS
AB Background. Although rates of tuberculosis (TB) in the United States have decreased in recent years, disparities in TB incidence still exist between U.S.-born and foreign-born people (people living in the United States but born outside it) and between white people and nonwhite people. In addition, the number of TB outbreaks among health care personnel and patients has decreased since the implementation of the 1994 Centers for Disease Control and Prevention (CDC) guidelines to prevent transmission of Mycobacterium tuberculosis. In this article, the authors provide updates on the epidemiology of TB, advances in TB diagnostic methods and TB infection control guidelines for dental settings.
Results. In 2008, 83 percent of all reported TB cases in the United States occurred in nonwhite people and 17 percent occurred in white people. Foreign-born people had a TB rate about 10 times higher than that of U.S.-born people. New blood assays for M. tuberculosis have been developed to diagnose TB infection and disease. Changes from the 1994 CDC guidelines incorporated into CDC's "Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Settings, 2005" include revised risk classifications, new TB diagnostic methods, decreased frequencies of tuberculin skin testing in various settings and changes in terminology. Clinical Implications. Although the principles of TB infection control have remained the same, the changing epidemiology of TB and the advent of new diagnostic methods for TB led to the development of the 2005 update to the 1994 guidelines. Dental health care personnel should be aware of the modifications that are pertinent to dental settings and incorporate them into their overall infection control programs.
C1 [Cleveland, Jennifer L.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Oral Hlth, Atlanta, GA 30341 USA.
[Robison, Valerie A.] Ctr Dis Control & Prevent, Natl Ctr HIVAIDS Hepatitis STD & TB Prevent, Div TB Eliminat, Atlanta, GA 30341 USA.
[Panlilio, Adelisa L.] Ctr Dis Control & Prevent, Natl Ctr Preparedness Detect & Control Infect Dis, Div Healthcare Qual Promot, Atlanta, GA 30341 USA.
RP Cleveland, JL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Oral Hlth, MS F-10,4770 Buford Highway, Atlanta, GA 30341 USA.
EM JLCleveland@cdc.gov
NR 27
TC 12
Z9 12
U1 1
U2 12
PU AMER DENTAL ASSOC
PI CHICAGO
PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA
SN 0002-8177
J9 J AM DENT ASSOC
JI J. Am. Dent. Assoc.
PD SEP
PY 2009
VL 140
IS 9
BP 1092
EP 1099
PG 8
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 492RL
UT WOS:000269676800013
PM 19723941
ER
PT J
AU Weaver, JB
Mays, D
Lindner, G
Eroglu, D
Fridinger, F
Bernhardt, JM
AF Weaver, James B., III
Mays, Darren
Lindner, Gregg
Eroglu, Dogan
Fridinger, Frederick
Bernhardt, Jay M.
TI Profiling Characteristics of Internet Medical Information Users
SO JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
LA English
DT Article
ID NATIONAL TRENDS SURVEY; HEALTH INFORMATION; DIGITAL DIVIDE;
INTERVENTIONS; TECHNOLOGY; CONSUMERS; ILLNESS; IMPACT
AB Objective: The Internet's potential to bolster health promotion and disease prevention efforts has attracted considerable attention. Existing research leaves two things unclear, however: the prevalence of online health and medical information seeking and the distinguishing characteristics of individuals who seek that information.
Design: This study seeks to clarify and extend the knowledge base concerning health and medical information use online by profiling adults using Internet medical information (IMI). Secondary analysis of survey data from a large sample (n = 6,119) representative of the Atlanta, GA, area informed this investigation.
Measurements: Five survey questions were used to assess IMI use and general computer and Internet use during the 30 days before the survey was administered. Five questions were also used to assess respondents' health care system use. Several demographic characteristics were measured.
Results: Contrary to most prior research, this study found relatively low prevalence of IMI-seeking behavior. Specifically, IMI use was reported by 13.2% of all respondents (n = 6,119) and by 21.1% of respondents with Internet access (n = 3,829). Logistic regression models conducted among respondents accessing the Internet in the previous 30 days revealed that, when controlling for several sociodemographic characteristics, home computer ownership, online time per week, and health care system use are all positively linked with IMI-seeking behavior.
Conclusions: The data suggest it may be premature to embrace unilaterally the Internet as an effective asset for health promotion and disease prevention efforts that target the public.
C1 [Weaver, James B., III; Mays, Darren; Eroglu, Dogan; Fridinger, Frederick; Bernhardt, Jay M.] Ctr Dis Control & Prevent, Natl Ctr Hlth Mkt, Atlanta, GA 30333 USA.
[Mays, Darren] Emory Univ, Dept Behav Sci & Hlth Educ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Lindner, Gregg] Scarborough Res, New York, NY USA.
RP Weaver, JB (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Mkt, 1600 Clifton Rd,MS-E21, Atlanta, GA 30333 USA.
EM Jim.Weaver@CDC.GOV
OI Bernhardt, Jay/0000-0002-2045-4005
FU Scarborough Research
FX The authors are indebted to Jennifer Cadoret, Richard E. Dixon, and
Marinella Macri for their significant contributions to this project.
This research was supported in part by Scarborough Research and by the
appointment of the first and second authors to the Research
Participation Program at the Centers for Disease Control and Prevention
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the United States Department of
Energy and CDC.
NR 50
TC 35
Z9 35
U1 3
U2 17
PU HANLEY & BELFUS-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1067-5027
J9 J AM MED INFORM ASSN
JI J. Am. Med. Inf. Assoc.
PD SEP-OCT
PY 2009
VL 16
IS 5
BP 714
EP 722
DI 10.1197/jamia.M3150
PG 9
WC Computer Science, Information Systems; Computer Science,
Interdisciplinary Applications; Information Science & Library Science;
Medical Informatics
SC Computer Science; Information Science & Library Science; Medical
Informatics
GA 493RL
UT WOS:000269755500013
PM 19567794
ER
PT J
AU Harrison, BA
Whitt, PB
Roberts, LF
Lehman, JA
Lindsey, NP
Nasci, RS
Hansen, GR
AF Harrison, Bruce A.
Whitt, Parker B.
Roberts, Lesa F.
Lehman, Jennifer A.
Lindsey, Nicole P.
Nasci, Roger S.
Hansen, Gail R.
TI RAPID ASSESSMENT OF MOSQUITOES AND ARBOVIRUS ACTIVITY AFTER FLOODS IN
SOUTHEASTERN KANSAS, 2007
SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION
LA English
DT Article
DE Rapid assessment; mosquitoes; West Nile virus; Kansas
ID WEST-NILE-VIRUS; FIELD-COLLECTED MOSQUITOS; NEW-YORK; NEUROINVASIVE
DISEASE; AMPLIFICATION ASSAYS; ENCEPHALITIS VIRUSES; HURRICANE-KATRINA;
UNITED-STATES; CULICIDAE; DIPTERA
AB A rapid assessment was conducted in July-August 2007 to determine the impact of heavy rains and early summer floods on the mosquitoes and arbovirus activity in 4 southeastern Kansas counties. During 10 days and nights of collections using different types and styles of mosquito traps, a total of 10,512 adult female mosquitoes representing 29 species were collected, including a new species record for Kansas (Psorophora mathesoni). High numbers of Aedes albopictus were collected. Over 4,000 specimens of 4 Culex species in 235 species-specific pools were tested for the presence of West Nile, St. Louis, and western equine encephalitis viruses. Thirty pools representing 3 Culex species were positive for West Nile virus (WNV). No other arboviruses were detected in the samples. Infection rates of WNV in Culex pipiens complex in 2 counties (10.7/1,000 to 22.6/1,000) and in Culex salinarius in 1 county (6.0/1,000) were sufficiently high to increase the risk or transmission to humans. The infection rate of WNV in Culex erraticus was 1.9/1,000 in one county. Two focal hot spots of intense WNV transmission were identified in Montgomery and Wilson counties, where infection rates in Cx. pipiens complex were 26/1,000 and 19.9/1,000, respectively. Despite confirmed evidence of WNV activity in the area, there was no increase in human cases of arboviral disease documented in the 4 counties for the remainder of 2007.
C1 [Harrison, Bruce A.; Whitt, Parker B.] N Carolina Dept Environm & Nat Resources, Winston Salem, NC 27107 USA.
[Roberts, Lesa F.; Hansen, Gail R.] Kansas Dept Hlth & Environm, Off Surveillance & Epidemiol, Topeka, KS 66612 USA.
[Lehman, Jennifer A.; Lindsey, Nicole P.; Nasci, Roger S.] Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Infect Dis, Ft Collins, CO 80522 USA.
RP Harrison, BA (reprint author), N Carolina Dept Environm & Nat Resources, 585 Waughtown St, Winston Salem, NC 27107 USA.
FU North Carolina Division of Environmental Health
FX The assistance of many people was necessary to make this investigation
possible. Under Sheriff Sid Howell (Montgomery), Deputy Sheriffs' Dan
Ferguson (Elk) and Byron Shultz (Neosho), and Health Department
Administrator Todd Durham (Wilson) set and retrieved traps each day.
Space, logistical support, environmental health guidance, and
administrative support were provided by Jim Miller, Kathy Craig, Scott
Barnhart, Scott Gordon, Lois Kelly, and Theresa Paulter, in the
Montgomery County Emergency Operations Center. Mosquito pools were
tested by Kristen Birkhalter and Bethany Swope, CDC, Ft. Collins, CO. A.
J. Thomas, Kansas Department of Health and Environment, Topeka, provided
GIS maps of the flooded areas. Harry Savage and Edward Hayes from the
CDC provided supplies, shipping containers, and valuable advice. Mike
Kelly, Nolan Newton, and Marcee Toliver, North Carolina Division of
Environmental Health, provided logistical and technical support and
guidance, making the trip feasible.
NR 25
TC 6
Z9 7
U1 2
U2 5
PU AMER MOSQUITO CONTROL ASSOC
PI EATONTOWN
PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA
SN 8756-971X
J9 J AM MOSQUITO CONTR
JI J. Am. Mosq. Control Assoc.
PD SEP
PY 2009
VL 25
IS 3
BP 265
EP 271
DI 10.2987/08-5754.1
PG 7
WC Entomology
SC Entomology
GA 504EN
UT WOS:000270598300007
PM 19852215
ER
PT J
AU Goble, S
Neal, M
Clark, DE
Nathens, AB
Annest, JL
Faul, M
Sattin, RW
Li, L
Levy, PS
Mann, NC
Guice, K
Cassidy, LD
Fildes, JJ
AF Goble, Sandra
Neal, Melanie
Clark, David E.
Nathens, Avery B.
Annest, J. Lee
Faul, Mark
Sattin, Richard W.
Li, Lei
Levy, Paul S.
Mann, N. Clay
Guice, Karen
Cassidy, Laura D.
Fildes, John J.
TI Creating a Nationally Representative Sample of Patients From Trauma
Centers
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article; Proceedings Paper
CT 67th Annual Meeting of the
American-Association-for-the-Surgery-of-Trauma
CY SEP 24-27, 2008
CL Maui, HI
SP Amer Assoc Surg Trauma
DE Injury; National Sample; Trauma center; NTDB; NIS; TIEP
ID HOSPITAL DISCHARGE
AB Background: The National Trauma Data Bank (NTDB) was developed as a convenience sample of registry data from contributing trauma centers (TCs), thus, inferences about trauma patients may not be valid at the national level. The NTDB National Sample was created to obtain nationally representative estimates of trauma patients treated in the US level I and 11 TCs.
Methods: Level I and 11 TCs in the Trauma Information Exchange Program were identified and a random stratified sample of 100 TCs was selected. The probability-proportional-to-size method was used to select TCs and sample weights were calculated. National Sample Program estimates from 2003 to 2006 were compared with raw NTDB data, and to a subset of TCs in the Healthcare Cost and Utilization Project Nationwide Inpatient Sample, a population-based dataset drawn from community hospitals.
Results: Weighted estimates from the NTDB National Sample range from 484,000 (2004) to 608,000 (2006) trauma incidents. Crude NTDB data over-represented the proportion of younger patients (0 years-14 years) compared with the NTDB National Sample, which does not include children's hospitals. Few TCs in Trauma Information Exchange Program are included in Healthcare Cost and Utilization Project Nationwide Inpatient Sample, but estimates based on this subset indicate a higher percentage of older patients (age 65 year or older, 23.98% versus 17.85%), lower percentage male patients, and a lower percentage of motor vehicle accidents compared with NTDB National Sample.
Conclusion: Although nationally representative data regarding trauma patients are available in other population-based samples, they do not represent TCs patients and lack the specificity of National Sample Program data, which contains detailed information on injury mechanisms, diagnoses, and hospital treatment.
C1 [Goble, Sandra; Neal, Melanie; Clark, David E.; Nathens, Avery B.; Fildes, John J.] Amer Coll Surg, Comm Trauma, Chicago, IL USA.
[Clark, David E.] Maine Med Ctr, Dept Surg, Portland, ME 04102 USA.
[Nathens, Avery B.] Univ Toronto, Dept Surg, Toronto, ON, Canada.
[Annest, J. Lee; Faul, Mark] CDC, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA.
[Sattin, Richard W.] Med Coll Georgia, Dept Emergency Med, Augusta, GA 30912 USA.
[Li, Lei; Levy, Paul S.] RTI Int, Div Stat Res, Res Triangle Pk, NC USA.
[Mann, N. Clay] Univ Utah, Sch Med, Dept Pediat, Salt Lake City, UT USA.
[Guice, Karen; Cassidy, Laura D.] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
[Fildes, John J.] Univ Nevada, Dept Surg, Las Vegas, NV 89154 USA.
RP Clark, DE (reprint author), 887 Congress St, Portland, ME 04102 USA.
EM clarkd@mmc.org
NR 7
TC 10
Z9 10
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD SEP
PY 2009
VL 67
IS 3
BP 637
EP 644
DI 10.1097/TA.0b013e3181b84294
PG 8
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA 493IL
UT WOS:000269729900040
PM 19741413
ER
PT J
AU Kornylo, K
Kim, DK
Widdowson, MA
Turabelidze, G
Averhoff, FM
AF Kornylo, Krista
Kim, David K.
Widdowson, Marc-Alain
Turabelidze, George
Averhoff, Francisco M.
TI Risk of Norovirus Transmission during Air Travel
SO JOURNAL OF TRAVEL MEDICINE
LA English
DT Article
CT 10th Conference of the International-Society-of-Travel-Medicine
CY MAY 20-24, 2007
CL Vancouver, CANADA
SP Int Soc Travel Med
AB Background. During October 2006, an outbreak of norovirus gastroenteritis sickened 200 (59%) of the 379 passengers and 26 (18%) of the 144 crew members on a riverboat. In November 2006, CDC was notified that a group of ill passengers had boarded a commercial flight from St Louis, Missouri, to Atlanta, Georgia. A recent study demonstrated probable norovirus transmission from eight symptomatic flight attendants to passengers on board an aircraft during an international flight; however, there are no published reports of transmission of norovirus on flights of short duration.
Methods. We investigated the risk of norovirus transmission on a short flight as part of an outbreak response. Using a standardized questionnaire, we conducted interviews of passengers and flight attendants who were on the flight. We collected information on traveler demographics and illness before, during, and after the flight. We also collected information about potential onboard risk factors for norovirus transmission, such as proximity and contact with ill appearing persons during the flight, as well as use of onboard lavatories and hand hygiene.
Results. We were able to complete questionnaires for 50 (56%) of the 89 passengers on the flight and 2 (67%) of the 3 flight attendants. Two (5%) of 42 possible secondary cases were identified. These two passengers neither sat in proximity to an index-case passenger during the flight nor reported use of an onboard lavatory.
Conclusions. Although onboard transmission cannot be excluded, likelihood of norovirus transmission on a short flight when ill travelers do not have episodes of vomiting or diarrhea appears minimal.
C1 [Kornylo, Krista; Kim, David K.; Widdowson, Marc-Alain; Averhoff, Francisco M.] CDC, NCPDCID, Atlanta, GA 30333 USA.
[Turabelidze, George] Missouri Dept Hlth & Senior Serv, Div Community & Publ Hlth, St Louis, MO USA.
RP Kornylo, K (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS E-03, Atlanta, GA 30333 USA.
EM frl3@cdc.gov
OI Widdowson, Marc-Alain/0000-0002-0682-6933
FU PHS HHS [U60/CCU007277]
NR 7
TC 7
Z9 8
U1 0
U2 7
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1195-1982
J9 J TRAVEL MED
JI J. Travel Med.
PD SEP-OCT
PY 2009
VL 16
IS 5
BP 349
EP 351
DI 10.1111/j.1708-8305.2009.00344.x
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 495PC
UT WOS:000269904800010
PM 19796107
ER
PT J
AU Yax, JA
Famon, EC
Engleberg, NC
AF Yax, Justin A.
Famon, Eileen C.
Engleberg, N. Cary
TI Successful Immunization of an Allogeneic Bone Marrow Transplant
Recipient with Live, Attenuated Yellow Fever Vaccine
SO JOURNAL OF TRAVEL MEDICINE
LA English
DT Article
ID SERIOUS ADVERSE EVENTS; ENOUGH
AB Vaccination against yellow fever is effective, but available live virus vaccines are not recommended for use in immunocompromised or elderly patients. We report the successful and uneventful immunization of a 62-year-old man with a history of allogeneic bone marrow transplant and discuss evidence for this recommendation.
C1 [Yax, Justin A.; Engleberg, N. Cary] Univ Michigan, Dept Internal Med, Sch Med, Ann Arbor, MI 48109 USA.
[Famon, Eileen C.] Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Infect Dis, Ft Collins, CO USA.
[Engleberg, N. Cary] Univ Michigan, Dept Microbiol & Immunol, Sch Med, Ann Arbor, MI 48109 USA.
RP Engleberg, NC (reprint author), Univ Michigan Hosp, 3119N Taubman Ctr Box 0378, Ann Arbor, MI 48109 USA.
EM cengleb@umich.edu
NR 15
TC 13
Z9 13
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1195-1982
EI 1708-8305
J9 J TRAVEL MED
JI J. Travel Med.
PD SEP-OCT
PY 2009
VL 16
IS 5
BP 365
EP 367
DI 10.1111/j.1708-8305.2009.00336.x
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 495PC
UT WOS:000269904800013
PM 19796110
ER
PT J
AU Bagget, HC
Arguin, PM
Kozarsky, PE
Reed, C
AF Bagget, Henry C.
Arguin, Paul M.
Kozarsky, Phyllis E.
Reed, Christie
TI Travel and Oral Anticoagulants Response
SO JOURNAL OF TRAVEL MEDICINE
LA English
DT Letter
C1 [Bagget, Henry C.] US CDC Collaborat, Int Emerging Infect Program, Thailand Minist Publ Hlth, Bangkok, Thailand.
[Arguin, Paul M.; Kozarsky, Phyllis E.; Reed, Christie] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Bagget, HC (reprint author), US CDC Collaborat, Int Emerging Infect Program, Thailand Minist Publ Hlth, Bangkok, Thailand.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1195-1982
J9 J TRAVEL MED
JI J. Travel Med.
PD SEP-OCT
PY 2009
VL 16
IS 5
BP 371
EP 371
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 495PC
UT WOS:000269904800017
ER
PT J
AU Asghar, RJ
Patlan, DE
Miner, MC
Rhodes, HD
Solages, A
Katz, DJ
Beall, DS
Ijaz, K
Oeltmann, JE
AF Asghar, Rana Jawad
Patlan, David E.
Miner, Mark C.
Rhodes, Halsey D.
Solages, Anthony
Katz, Dolly J.
Beall, David S.
Ijaz, Kashef
Oeltmann, John E.
TI Limited Utility of Name-Based Tuberculosis Contact Investigations among
Persons Using Illicit Drugs: Results of an Outbreak Investigation
SO JOURNAL OF URBAN HEALTH-BULLETIN OF THE NEW YORK ACADEMY OF MEDICINE
LA English
DT Article
DE Tuberculosis; Drug resistance; Outbreak; Substance abuse; Contact
investigations
AB Persons named by a patient with tuberculosis (TB) are the focus of traditional TB contact investigations. However, patients who use illicit drugs are often reluctant to name contacts. Between January 2004 and May 2005, 18 isoniazid-resistant TB cases with matching Mycobacterium tuberculosis genotypes (spoligotypes) were reported in Miami; most patients frequented crack houses and did not name potentially infected contacts. We reviewed medical records and reinterviewed patients about contacts and locations frequented to describe transmission patterns and make recommendations to control TB in this population. Observed contacts were not named but were encountered at the same crack houses as the patients. Contacts were evaluated for latent TB infection with a tuberculosis skin test (TST). All 18 patients had pulmonary TB. Twelve (67%) reported crack use and 14 (78%) any illicit drug use. Of the 187 contacts evaluated, 91 (49%) were named, 16 (8%) attended a church reported by a patient, 61 (33%) used a dialysis center reported by a patient, and 19 (10%) were observed contacts at local crack houses. Compared to named contacts, observed contacts were eight times as likely to have positive TST results (relative risk = 7.8; 95% confidence interval = 3.8-16.1). Dialysis center and church contacts had no elevated risk of a positive TST result. Testing observed contacts may provide a higher yield than traditional name-based contact investigations for tuberculosis patients who use illicit drugs or frequent venues characterized by illicit drug use.
C1 [Asghar, Rana Jawad; Patlan, David E.; Miner, Mark C.; Katz, Dolly J.; Ijaz, Kashef; Oeltmann, John E.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA.
[Asghar, Rana Jawad] Off Workforce & Career Dev, Epidem Intelligence Serv, Atlanta, GA USA.
[Rhodes, Halsey D.] Florida Dept Hlth, Tallahassee, FL USA.
[Solages, Anthony] Baptist Hosp Miami, Miami, FL USA.
[Beall, David S.] Florida Community Coll, Jacksonville, FL USA.
RP Oeltmann, JE (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA.
EM jeo3@cdc.gov
NR 11
TC 24
Z9 25
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1099-3460
J9 J URBAN HEALTH
JI J. Urban Health
PD SEP
PY 2009
VL 86
IS 5
BP 776
EP 780
DI 10.1007/s11524-009-9378-z
PG 5
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 486KP
UT WOS:000269195200010
PM 19533366
ER
PT J
AU Nemeth, NM
Young, GR
Burkhalter, KL
Brault, AC
Reisen, WK
Komar, N
AF Nemeth, Nicole M.
Young, Ginger R.
Burkhalter, Kristen L.
Brault, Aaron C.
Reisen, William K.
Komar, Nicholas
TI West Nile virus detection in nonvascular feathers from avian carcasses
SO JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
LA English
DT Article
DE Birds; diagnosis; feather; reverse transcription polymerase chain
reaction; West Nile virus
ID POLYMERASE-CHAIN-REACTION; MAREKS-DISEASE VIRUS; EARLY WARNING SYSTEM;
INFLUENZA-VIRUS; MORTALITY SURVEILLANCE; PSITTACINE BIRDS; HUMAN
INFECTION; COLORADO; ANTIGEN; BEAK
AB West Nile virus (WNV) is a public health threat and has caused the death of thousands of North American birds. As such, surveillance for WNV has been ongoing, utilizing numerous biological specimens and testing methods. Nonvascular (i.e., fully grown) feathers would provide a simple method of collection from either dead or live birds of all ages and molt cycles, with presumably less biosafety risk compared with other specimen types, including feather pulp. The current study evaluates WNV detection in nonvascular feathers removed from naturally infected avian carcasses of several species groups. Feathers of corvid passeriforms had the highest sensitivity of detection (64%), followed by noncorvid passeriforms (43%), columbiforms (33%), and falconiforms (31%). Storing feathers for 1 year at -20 degrees C or at ambient room temperature resulted in detection rates of infectious WNV of 16% and zero, respectively, but had no effect on detection rates of WNV RNA in a subset of matched feather pairs (47% for both storage temperatures). The efficacy of WNV detection in nonvascular feathers is greatly enhanced by testing multiple feathers. The advantages of using nonvascular feathers over other tissues may outweigh the relatively low detectability of WNV RNA in certain situations such as remote areas lacking resources for acquiring other types of samples or maintaining the cold chain.
C1 [Nemeth, Nicole M.; Young, Ginger R.; Burkhalter, Kristen L.; Komar, Nicholas] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA.
[Brault, Aaron C.; Reisen, William K.] Univ Calif Davis, Arbovirus Res Unit, Ctr Vector Borne Dis, Dept Pathol Microbiol & Immunol,Sch Vet Med, Davis, CA 95616 USA.
RP Nemeth, NM (reprint author), USDA APHIS WS, Natl Wildlife Res Ctr, Ft Collins, CO 80521 USA.
EM nnemeth@colostate.edu
FU Pacific Southwest Regional Center for Excellence (PSWRCE) [U54 Al-65359]
FX The authors are grateful to the following for providing samples: Gail
Kratz, Judy Scherpelz, Lisa Winta, Carin Avila, and Rebecca Bates of the
Rocky Mountain Raptor Program, Bob Nightwalker and Jessica Plunkett of
Wild-Kind (Larimer County Humane Society), and Jackie Parker of
California Animal Health and Food Safety Laboratory. Richard Bowen
(Colorado State University) and Susan Beckett (CDC) provided logistical
Support, and Maureen Dannen and Ying Fang (University of California,
Davis) provided technical support. Funding for RNA detection platforms
used for WNV RNA detection was partially provided by the Pacific
Southwest Regional Center for Excellence (PSWRCE) U54 Al-65359.
NR 38
TC 7
Z9 7
U1 2
U2 10
PU AMER ASSOC VETERINARY LABORATORY DIAGNOSTICIANS INC
PI TURLOCK
PA PO BOX 1522, TURLOCK, CA 95381 USA
SN 1040-6387
J9 J VET DIAGN INVEST
JI J. Vet. Diagn. Invest.
PD SEP
PY 2009
VL 21
IS 5
BP 616
EP 622
PG 7
WC Veterinary Sciences
SC Veterinary Sciences
GA 496IH
UT WOS:000269963400005
PM 19737756
ER
PT J
AU Tamin, A
Harcourt, BH
Lo, MK
Roth, JA
Wolf, MC
Lee, B
Weingartl, H
Audonnet, JC
Bellini, WJ
Rota, PA
AF Tamin, Azaibi
Harcourt, Brian H.
Lo, Michael K.
Roth, James A.
Wolf, Mike C.
Lee, Benhur
Weingartl, Hana
Audonnet, Jean-Christophe
Bellini, William J.
Rota, Paul A.
TI Development of a neutralization assay for Nipah virus using pseudotype
particles
SO JOURNAL OF VIROLOGICAL METHODS
LA English
DT Article
DE Nipah virus; Diagnostics; Neutralization assays; Pseudotype particles;
Henipaviruses
ID EMERGENT DEADLY PARAMYXOVIRUS; HENDRA-VIRUS; ESCHERICHIA-COLI;
FLYING-FOXES; ENCEPHALITIS OUTBREAK; HENIPAVIRUS INFECTION; ABATTOIR
WORKERS; MEMBRANE-FUSION; FRUIT BATS; ANTIBODIES
AB Nipah virus (NiV) and Hendra virus (HeV) are zoonotic paramyxoviruses capable of causing severe disease in humans and animals. These viruses require biosafety level 4 (BSL-4) containment. Like other paramyxoviruses, the plaque reduction neutralization test (PRNT) can be used to detect antibodies to the surface glycoproteins, fusion (F) and attachment (G), and PRNT titers give an indication of protective immunity. Unfortunately, for NiV and HeV, the PRNT must be performed in BSL-4 containment and takes several days to complete. Thus, we have developed a neutralization assay using VSV pseudotype particles expressing the F and G proteins of NiV (pVSV-NiV-F/G) as target antigens. This rapid assay, which can be performed at BSL-2, was evaluated using serum samples from outbreak investigations and more than 300 serum samples from an experimental NiV vaccination study in swine. The results of the neutralization assays with pVSV-NiV-F/G as antigen showed a good correlation with those of standard PRNT. Therefore, this new method has the potential to be a rapid and cost-effective diagnostic method, especially in locations that lack high containment facilities, and will provide a valuable tool for basic research and vaccine development. Published by Elsevier B.V.
C1 [Tamin, Azaibi; Harcourt, Brian H.; Lo, Michael K.; Bellini, William J.; Rota, Paul A.] Ctr Dis Control & Prevent, Div Viral Dis, Measles Mumps Rubella & Herpesvirus Lab Branch, Atlanta, GA 30333 USA.
[Roth, James A.] Iowa State Univ, Coll Vet Med, Ames, IA USA.
[Wolf, Mike C.; Lee, Benhur] UCLA AIDS Inst, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA USA.
[Weingartl, Hana] Canadian Food Inspect Agcy, Winnipeg, MB, Canada.
[Audonnet, Jean-Christophe] Merial, Lyon, France.
RP Rota, PA (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Measles Mumps Rubella & Herpesvirus Lab Branch, MS-C-22,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM prota@cdc.gov
RI Roth, James/A-7122-2009; Lee, Benhur/A-8554-2016;
OI Roth, James/0000-0003-3562-668X; Lee, Benhur/0000-0003-0760-1709; Lo,
Michael/0000-0002-0409-7896
FU NIH [R21 AI058038, R01 AI60694, T32 AI07323]; UCLA Warsaw Fellowship
FX The authors wish to acknowledge financial support from NIH: R21 AI058038
(to JAR), R01 AI60694 (to BL), and T32 AI07323 (to MCW). MCW also
acknowledges support from the UCLA Warsaw Fellowship.
NR 57
TC 26
Z9 30
U1 4
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-0934
J9 J VIROL METHODS
JI J. Virol. Methods
PD SEP
PY 2009
VL 160
IS 1-2
BP 1
EP 6
DI 10.1016/j.jviromet.2009.02.025
PG 6
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Virology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Virology
GA 472HQ
UT WOS:000268121600001
PM 19559943
ER
PT J
AU Workman, S
Wells, SK
Pau, CP
Owen, SM
Dong, XF
LaBorde, R
Granade, TC
AF Workman, Shon
Wells, Susan K.
Pau, Chou-Pong
Owen, S. Michele
Dong, X. Fan
LaBorde, Ron
Granade, Timothy C.
TI Rapid detection of HIV-1 p24 antigen using magnetic
immuno-chromatography (MICT)
SO JOURNAL OF VIROLOGICAL METHODS
LA English
DT Article
DE Human immunodeficiency virus; p24 antigen; Rapid tests; Lateral flow
immunoassays
ID IMMUNODEFICIENCY-VIRUS TYPE-1; ANTIBODY COMBINATION ASSAYS; DRIED BLOOD
SPOTS; DAR-ES-SALAAM; SIGNAL-AMPLIFICATION; DIAGNOSTIC WINDOW;
INFECTION; SEROCONVERSION; RNA; TRANSMISSION
AB Detection of human immunodeficiency virus (HIV) infections has been enhanced by incorporating p24 antigen detection with current HIV antibody detection using enzyme immunoassays (EIAs). However, screening for HIV antibodies has increased through the use of rapid, lateral-flow HIV antibody detection assays that currently do not have the capability to detect HIV p24 antigen. In this report, a lateral-flow based assay using super-paramagnetic particles as the detection marker was developed for the detection of HIV-1 p24 antigen. This magnetic immuno-chromatographic test (MICT) uses an inexpensive, low-maintenance instrument that detects the magnetic moment of the super-paramagnetic particles in a magnetic field. MICT is simple to perform, provides a numerical output for easier determination of reactive results and can be completed in 40 min. The lower limit of detection for HIV-1 p24 spiked into assay sample buffer and 50% plasma was 30 pg/ml for both. Detection of HIV-1 p24 antigen at 50 pg/ml was reproducible in both inter-run and intra-run assays with coefficients of variation of <13%. Furthermore, the MICT p24 assay was able to detect intact virus spiked into 50% plasma (lower detection limit of similar to 250,000 viral RNA copies/ml). MICT detection of increasing HIV-1 p24 levels in commercially available seroconversion panels by MICT was only slightly later than that detected by much more complex EIAs. MICT could provide a simple, low-cost, and portable method for rapid HIV-1 p24 detection in a variety of testing environments. Published by Elsevier B.V.
C1 [Workman, Shon; Wells, Susan K.; Pau, Chou-Pong; Owen, S. Michele; Granade, Timothy C.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
[Dong, X. Fan] Pacific BioPharm, San Diego, CA 92121 USA.
[LaBorde, Ron] MagnaBiosciences LLC, San Diego, CA 92121 USA.
RP Granade, TC (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE Mailstop A-25, Atlanta, GA 30333 USA.
EM TGranade@cdc.gov
NR 37
TC 32
Z9 33
U1 1
U2 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-0934
J9 J VIROL METHODS
JI J. Virol. Methods
PD SEP
PY 2009
VL 160
IS 1-2
BP 14
EP 21
DI 10.1016/j.jviromet.2009.04.003
PG 8
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Virology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Virology
GA 472HQ
UT WOS:000268121600003
PM 19482361
ER
PT J
AU van der Sanden, S
Pallansch, MA
van de Kassteele, J
El-Sayed, N
Sutter, RW
Koopmans, M
Van der Avoort, H
AF van der Sanden, Sabine
Pallansch, Mark A.
van de Kassteele, Jan
El-Sayed, Nasr
Sutter, Roland W.
Koopmans, Marion
Van der Avoort, Harrie
TI Shedding of Vaccine Viruses with Increased Antigenic and Genetic
Divergence after Vaccination of Newborns with Monovalent Type 1 Oral
Poliovirus Vaccine
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID IMMUNODEFICIENT PATIENT; EVOLUTION; CIRCULATION; RECEPTOR;
POLIOMYELITIS; ERADICATION; SENSITIVITY; SEROTYPES; EXCRETION; MUTATION
AB For the final stages in the eradication of poliovirus type 1 (P1), the World Health Organization advocates the selective use of monovalent type 1 oral poliovirus vaccine (mOPV1). To compare the immunogenicity of mOPV1 with that of trivalent OPV (tOPV) in infants, a study was performed in Egypt in 2005. Newborns were vaccinated with mOPV1 or tOPV immediately after birth and were challenged with mOPV1 after 1 month. Vaccination with mOPV1 at birth resulted in significantly higher seroconversion against P1 viruses and lower excretion of P1 viruses than vaccination with tOPV. Intratypic differentiation of the viruses shed by the newborns revealed the presence of remarkably high numbers of antigenically divergent (AD) P1 isolates, especially in the mOPV1 study group. The majority of these AD P1 isolates (71%) were mOPV1 challenge derived and were shed by newborns who did not seroconvert to P1 after the birth dose. Genetic characterization of the viruses revealed that amino acid 60 of the VP3 region was mutated in all AD P1 isolates. Isolates with substitution of residue 99 of the VP1 region had significantly higher numbers of nonsynonymous mutations in the VP1 region than isolates without this substitution and were preferentially shed in the mOPV1 study group. The widespread use of mOPV1 has proven to be a powerful tool for fighting poliovirus circulation in the remaining areas of endemicity. This study provides another justification for the need to achieve high vaccination coverage in order to prevent the circulation of AD strains.
C1 [van der Sanden, Sabine; van de Kassteele, Jan; Koopmans, Marion; Van der Avoort, Harrie] RIVM, Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands.
[van der Sanden, Sabine; Koopmans, Marion] Erasmus MC, Rotterdam, Netherlands.
[Pallansch, Mark A.] CDC, Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[El-Sayed, Nasr] MOHP, Cairo, Egypt.
[Sutter, Roland W.] WHO, CH-1211 Geneva, Switzerland.
RP van der Sanden, S (reprint author), RIVM, Natl Inst Publ Hlth & Environm, POB 1, NL-3720 BA Bilthoven, Netherlands.
EM Sabine.van.der.Sanden@rivm.nl
FU World Health Organization
FX This work was supported by the World Health Organization.
NR 43
TC 14
Z9 14
U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD SEP
PY 2009
VL 83
IS 17
BP 8693
EP 8704
DI 10.1128/JVI.02388-08
PG 12
WC Virology
SC Virology
GA 485LF
UT WOS:000269122300037
PM 19515771
ER
PT J
AU Wong, SK
Connole, M
Sullivan, JS
Choe, H
Carville, A
Farzan, M
AF Wong, Swee Kee
Connole, Michelle
Sullivan, JoAnne S.
Choe, Hyeryun
Carville, Angela
Farzan, Michael
TI A New World Primate Deficient in Tetherin-Mediated Restriction of Human
Immunodeficiency Virus Type 1
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID CYCLOPHILIN-A; HIV-1 INFECTION; ANCHORED PROTEINS; MONKEY CELLS;
RETROTRANSPOSITION; ADAPTATION; RESISTANT; APOBEC3G; CYSTEINE; RELEASE
AB Human immunodeficiency virus type 1 (HIV-1) does not replicate in primary cells of New World primates. To better understand this restriction, we expressed owl monkey (Aotus nancymaae) CD4 and CXCR4 in the owl monkey kidney cell line, OMK. An HIV-1 variant modified to evade the owl monkey restriction factor TRIM-cyp replicated efficiently in these cells but could not replicate in primary A. nancymaae CD4-positive T cells. To understand this difference, we examined APOBEC3G and tetherin orthologs from OMK cells and primary A. nancymaae cells. We observed that OMK cells expressed substantially lower levels of APOBEC3G than did A. nancymaae cells. A. nancymaae, but not marmoset (Callithrix jacchus), APOBEC3G was partially downregulated by HIV-1 vif and reduced but did not abolish HIV-1 replication when stably expressed in OMK cells. The functional difference between A. nancymaae and marmoset APOBEC3Gs mapped to residue 128, previously shown to distinguish African green monkey from human APOBEC3G. We also characterized tetherin orthologs from OMK and A. nancymaae cells. The A. nancymaae tetherin ortholog, but not OMK tetherin, prevented HIV-1 release. Alteration of threonine 181 of OMK tetherin rescued its function and its efficient N glycosylation. All alleles of Aotus lemurinus griseimembra examined, but none of A. nancymaae or Aotus vociferans, encoded this nonfunctional tetherin ortholog. Our data indicate that HIV-1 replication in owl monkeys is not restricted at entry but can be limited by APOBEC3G and tetherin. Further, A. lemurinus griseimembra does not restrict HIV-1 replication via tetherin, a property likely useful for the study of tetherin-restricted viruses.
C1 [Farzan, Michael] Harvard Univ, Sch Med, New England Primate Res Ctr, Dept Microbiol & Mol Genet, Southborough, MA 01772 USA.
[Sullivan, JoAnne S.] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Parasit Dis, Atlanta, GA USA.
[Sullivan, JoAnne S.] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Anim Resources Branch, Atlanta, GA USA.
[Choe, Hyeryun] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA.
[Choe, Hyeryun] Childrens Hosp, Perlmutter Lab, Boston, MA 02115 USA.
RP Farzan, M (reprint author), Harvard Univ, Sch Med, New England Primate Res Ctr, Dept Microbiol & Mol Genet, 1 Pine Hill Dr, Southborough, MA 01772 USA.
EM farzan@hms.harvard.edu
FU NIAID NIH HHS [T32 AI007387, R01 AI043891]
NR 25
TC 17
Z9 17
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD SEP
PY 2009
VL 83
IS 17
BP 8771
EP 8780
DI 10.1128/JVI.00112-09
PG 10
WC Virology
SC Virology
GA 485LF
UT WOS:000269122300044
PM 19553332
ER
PT J
AU Trivers, KF
Stewart, SL
Peipins, L
Rim, SH
White, MC
AF Trivers, Katrina F.
Stewart, Sherri L.
Peipins, Lucy
Rim, Sun Hee
White, Mary C.
TI Expanding the Public Health Research Agenda for Ovarian Cancer
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article; Proceedings Paper
CT 3rd Workshop of Ovarian Cancer Experts
CY NOV, 2008
CL Ctr Disease Control & Prevent, Atlanta, GA
HO Ctr Disease Control & Prevent
ID BRCA2 MUTATION CARRIERS; UNITED-STATES; SALPINGO-OOPHORECTOMY; PROTEOMIC
PATTERNS; DIAGNOSTIC MARKERS; RANDOMIZED-TRIAL; FAMILY-HISTORY; WOMEN;
SYMPTOMS; RISK
AB Since the year 2000, the Centers for Disease Control and Prevention (CDC) has undertaken an active public health research agenda in ovarian cancer, focused mainly on research related to earlier recognition of symptoms, methods for earlier diagnosis, and optimization of treatment and end-of-life care. Much of this work was guided by external input from two workshops in 2000 and 2002 with ovarian cancer experts in clinical and epidemiological research, public health leaders from federal and state agencies, and ovarian cancer survivors. In November 2008, the CDC convened a third informal workshop of experts to comment on CDC's work to date and to help expand the public health research agenda for the future. The purpose of the workshop was to identify and discuss urgent and emerging issues related to ovarian cancer and how public health organizations, and specifically CDC, might address these issues through research. This article provides a summary of some of the issues discussed and potential areas for future research, including genetic, screening, and diagnostic tests for ovarian cancer; ways of improving the quality of care for patients; symptom recognition; public awareness; and other emerging issues related to ovarian cancer.
C1 [Trivers, Katrina F.; Stewart, Sherri L.; Peipins, Lucy; Rim, Sun Hee; White, Mary C.] Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
RP Trivers, KF (reprint author), Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Ctr Dis Control & Prevent, 4770 Buford Highway,NE,MS K-55, Atlanta, GA 30341 USA.
EM ktrivers@cdc.gov
RI White, Mary /C-9242-2012
OI White, Mary /0000-0002-9826-3962
NR 63
TC 2
Z9 2
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD SEP
PY 2009
VL 18
IS 9
BP 1299
EP 1305
DI 10.1089/jwh.2009.1622
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Obstetrics & Gynecology; Women's Studies
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Obstetrics & Gynecology; Women's Studies
GA 492ZI
UT WOS:000269701600001
PM 19702475
ER
PT J
AU Chu, SY
Kim, SY
Bish, CL
AF Chu, Susan Y.
Kim, Shin Y.
Bish, Connie L.
TI Prepregnancy Obesity Prevalence in the United States, 2004-2005
SO MATERNAL AND CHILD HEALTH JOURNAL
LA English
DT Article
DE Maternal obesity; Prepregnancy obesity; Obesity prevalence; Pregnancy
Risk Assessment Monitoring System
ID BODY-MASS INDEX; GESTATIONAL DIABETES-MELLITUS; WEIGHT-GAIN; MATERNAL
OBESITY; BIRTH-WEIGHT; PREGNANCY; ASSOCIATION; OVERWEIGHT; CHILDHOOD;
MOTHERS
AB Objective To provide a current estimate of the prevalence of prepregnancy obesity in the United States. Methods We analyzed 2004-2005 data from 26 states and New York City (n = 75,403 women) participating in the Pregnancy Risk Assessment Monitoring System, an ongoing, population-based surveillance system that collects information on maternal behaviors associated with pregnancy. Information was obtained from questionnaires self-administered after delivery or from linked birth certificates; prepregnancy body mass index was based on self-reported weight and height. Data were weighted to provide representative estimates of all women delivering a live birth in each particular state. Results In this study, about one in five women who delivered were obese; in some state, race/ethnicity, and Medicaid status subgroups, the prevalence was as high as one-third. State-specific prevalence varied widely and ranged from 13.9 to 25.1%. Black women had an obesity prevalence about 70% higher than white and Hispanic women (black: 29.1%; white: 17.4%; Hispanic: 17.4%); however, these race-specific rates varied notably by location. Obesity prevalence was 50% higher among women whose delivery was paid for by Medicaid than by other means (e.g., private insurance, cash, HMO). Conclusion This prevalence makes maternal obesity and its resulting maternal morbidities (e.g., gestational diabetes mellitus) a common risk factor for a complicated pregnancy.
C1 [Chu, Susan Y.; Kim, Shin Y.; Bish, Connie L.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
RP Chu, SY (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,Mailstop K-23, Atlanta, GA 30341 USA.
EM syc1@cdc.gov
NR 39
TC 88
Z9 90
U1 0
U2 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1092-7875
J9 MATERN CHILD HLTH J
JI Matern. Child Health J.
PD SEP
PY 2009
VL 13
IS 5
BP 614
EP 620
DI 10.1007/s10995-008-0388-3
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 474VV
UT WOS:000268313300005
PM 18618231
ER
PT J
AU Kim, SY
England, L
Dietz, PM
Morrow, B
Perham-Hester, KA
AF Kim, Shin Y.
England, Lucinda
Dietz, Patricia M.
Morrow, Brian
Perham-Hester, Katherine A.
TI Prenatal Cigarette Smoking and Smokeless Tobacco Use Among Alaska Native
and White Women in Alaska, 1996-2003
SO MATERNAL AND CHILD HEALTH JOURNAL
LA English
DT Article
DE Smokeless tobacco; Cigarette smoking; Alaska Natives; Prevalence;
Pregnancy
ID PREGNANCY OUTCOMES; UNITED-STATES; NICOTINE; SNUFF; BIRTH; ADOLESCENTS;
EXPOSURE; COHORT; ADULTS; HEALTH
AB Objective To examine trends in prenatal cigarette smoking and smokeless tobacco use among Alaska Native (AN) and white women in Alaska. Methods Using 1996-2003 data from the population-based Pregnancy Risk Assessment Monitoring System, we determined trends in self-reported prenatal tobacco use among AN and white women and used chi-square tests and multiple variable logistic regression analysis to identify maternal factors associated with prenatal tobacco use. Results Over the study period, prevalence of any tobacco use during pregnancy declined by 27% among AN women (from 55.8 to 40.9%) (P < 0.0001) and by 17% among white women (from 18.8 to 15.6%) (P < 0.0001). In 2003, among AN women the prevalence of self-reported smokeless tobacco use was 16.9%, cigarette smoking was 25.7%, and any tobacco use was 40.9%; corresponding values for white women were 0.4, 15.0, and 15.6%, respectively. Western Alaska had the highest prevalence of tobacco use. Conclusion The prevalence of tobacco use decreased between 1996 and 2003, but remained higher among AN women than white women, especially for smokeless tobacco. Support for cessation interventions targeting pregnant women should be made a public health priority in Alaska.
C1 [Kim, Shin Y.; England, Lucinda; Dietz, Patricia M.; Morrow, Brian] Ctr Dis Control & Prevent, Div Reprod Hlth, Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Perham-Hester, Katherine A.] Sect Womens Childrens & Family Hlth, Div Publ Hlth, Dept Hlth & Social Serv, Anchorage, AK 99524 USA.
RP Kim, SY (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,MS K-23, Atlanta, GA 30341 USA.
EM skim1@cdc.gov
NR 27
TC 12
Z9 12
U1 1
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1092-7875
J9 MATERN CHILD HLTH J
JI Matern. Child Health J.
PD SEP
PY 2009
VL 13
IS 5
BP 652
EP 659
DI 10.1007/s10995-008-0402-9
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 474VV
UT WOS:000268313300009
PM 18712464
ER
PT J
AU Hayman, AV
Sofair, AN
Manos, MM
Thomas, A
Terrault, N
Van Ness, G
Stabach, N
Robert, M
Rumore, G
Corless, C
Bell, B
Bialek, S
Zaman, A
AF Hayman, Amanda V.
Sofair, Andre N.
Manos, M. Michele
Thomas, Ann
Terrault, Norah
Van Ness, Grace
Stabach, Nicole
Robert, Marie
Rumore, Gregory
Corless, Christopher
Bell, Beth
Bialek, Stephanie
Zaman, Atif
TI Prevalence and Predictors of Hepatic Steatosis in Adults With Newly
Diagnosed Chronic Liver Disease due to Hepatitis C
SO MEDICINE
LA English
DT Article
ID BODY-MASS INDEX; UNITED-STATES; NONALCOHOLIC STEATOHEPATITIS;
VIRUS-INFECTION; PROGRESSION; GENOTYPE; OBESITY; WEIGHT
AB Obesity appears to be a risk factor for hepatic steatosis, which has been implicated in the development of hepatic fibrosis in patients with hepatitis C virus infection. We conducted the current study to examine whether obesity is associated with hepatic steatosis among patients with chronic hepatitis C identified from a population-based cohort.
Study participants were persons with chronic hepatitis C who had had a liver biopsy, identified from a population-based study of persons with newly identified chronic liver disease conducted in gastroenterology practices. Data were collected through patient interviews, medical record abstraction, and review of previously performed liver biopsies. The outcome variable of interest was significant steatosis, defined as steatosis grade >= 2 determined from liver biopsy samples. Univariate and multivariate analyses were performed using logistic regression techniques.
The analysis included 450 patients with chronic hepatitis C with available liver biopsy slides. Overall, only 15.8% of subjects had significant hepatic steatosis (grade >= 2). while 35.9% of obese subjects had significant steatosis. In multivariate analysis, significant fibrosis (defined as >= grade 2) (odds ratio [OR], 3.43: 95% confidence interval [CI], 1.59-7.37), obesity (OR, 3.32; 95% CI, 1.84-5.98), genotype 3 (OR, 2.5; 95% CI, 1.09-5.75) and the presence of multiple metabolic comorbidities (OR, 1.9 1; 95% CI, 0.88-4.11) were independently associated with steatosis.
In this unique United States cohort of patients with newly diagnosed chronic liver disease due to hepatitis C, obesity was independently associated with hepatic steatosis. The results of this study provide additional evidence that obesity worsens liver damage in patients with chronic hepatitis C, and suggest a role for weight loss as a treatment modality in these patients.
C1 [Zaman, Atif] Oregon Hlth & Sci Univ, Div Gastroenterol & Hepatol, Portland, OR 97201 USA.
[Sofair, Andre N.; Stabach, Nicole; Robert, Marie] Yale Univ, Sch Med, New Haven, CT USA.
[Manos, M. Michele] Kaiser Permanente, Div Res, Oakland, CA USA.
[Thomas, Ann; Van Ness, Grace] Oregon Publ Hlth Div, Portland, OR USA.
[Terrault, Norah] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Rumore, Gregory] Kaiser Permanente, Med Grp, Oakland, CA USA.
[Bell, Beth; Bialek, Stephanie] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Zaman, A (reprint author), Oregon Hlth & Sci Univ, Div Gastroenterol & Hepatol, Mailcode L461,3181 SW Sam Jackson Pk Rd, Portland, OR 97201 USA.
EM zamana@ohsu.edu
FU Centers for Disease Control and Prevention
FX Funded through a cooperative agreement with the Centers for Disease
Control and Prevention.
NR 27
TC 2
Z9 2
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0025-7974
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP
PY 2009
VL 88
IS 5
BP 302
EP 306
DI 10.1097/MD.0b013e3181b954f4
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 499YX
UT WOS:000270264100006
PM 19745689
ER
PT J
AU Chamany, S
Silver, LD
Bassett, MT
Driver, CR
Berger, DK
Neuhaus, CE
Kumar, N
Frieden, TR
AF Chamany, Shadi
Silver, Lynn D.
Bassett, Mary T.
Driver, Cynthia R.
Berger, Diana K.
Neuhaus, Charlotte E.
Kumar, Namrata
Frieden, Thomas R.
TI Tracking Diabetes: New York City's A1C Registry
SO MILBANK QUARTERLY
LA English
DT Article
DE Diabetes; disease registry; surveillance; privacy
ID IMPROVING PRIMARY-CARE; PUBLIC-HEALTH; MICROVASCULAR COMPLICATIONS;
PHYSICAL-ACTIVITY; CHRONIC ILLNESS; ASSOCIATION; DISEASE; EPIDEMIC;
LESSONS; GLUCOSE
AB Context: In December 2005, in characterizing diabetes as an epidemic, the New York City Board of Health mandated the laboratory reporting of hemoglobin A1C laboratory test results. This mandate established the United States' first population-based registry to track the level of blood sugar control in people with diabetes. But mandatory A1C reporting has provoked debate regarding the role of public health agencies in the control of noncommunicable diseases and, more specifically, both privacy and the doctor-patient relationship.
Methods: This article reviews the rationale for adopting the rule requiring the reporting of A1C test results, experience with its implementation, and criticisms raised in the context of the history of public health practice.
Findings: For many decades, public health agencies have used identifiable information collected through mandatory laboratory reporting to monitor the population's health and develop programs for the control of communicable and noncommunicable diseases. The registry program sends quarterly patient rosters stratified by A1C level to more than one thousand medical providers, and it also sends letters, on the provider's letterhead whenever possible, to patients at risk of diabetes complications (A1C level >9 percent), advising medical follow-up. The activities of the registry program are similar to those of programs for other reportable conditions and constitute a joint effort between a governmental public health agency and medical providers to improve patients' health outcomes.
Conclusions: Mandatory reporting has proven successful in helping combat other major epidemics. New York City's A1C Registry activities combine both traditional and novel public health approaches to reduce the burden of an epidemic chronic disease, diabetes. Despite criticism that mandatory reporting compromises individuals' right to privacy without clear benefit, the early feedback has been positive and suggests that the benefits will outweigh the potential harms. Further evaluation will provide additional information that other local health jurisdictions may use in designing their strategies to address chronic disease.
C1 [Chamany, Shadi; Silver, Lynn D.; Driver, Cynthia R.; Neuhaus, Charlotte E.; Kumar, Namrata; Frieden, Thomas R.] New York City Dept Hlth & Mental Hyg, New York, NY USA.
[Neuhaus, Charlotte E.] New York City Hlth & Hosp Corp, New York, NY USA.
[Chamany, Shadi; Driver, Cynthia R.; Frieden, Thomas R.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Chamany, S (reprint author), Diabet Prevent & Control Program, 2 Lafayette St,20th Floor,CN 46, New York, NY 10007 USA.
EM schamany@health.nyc.gov
NR 55
TC 24
Z9 25
U1 2
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0887-378X
EI 1468-0009
J9 MILBANK Q
JI Milbank Q.
PD SEP
PY 2009
VL 87
IS 3
BP 547
EP 570
DI 10.1111/j.1468-0009.2009.00568.x
PG 24
WC Health Care Sciences & Services; Health Policy & Services
SC Health Care Sciences & Services
GA 505HX
UT WOS:000270684500002
PM 19751279
ER
PT J
AU Coleman, RE
Hochberg, LP
Putnam, JL
Swanson, KI
Lee, JS
McAvin, JC
Chan, AS
O'Guinn, ML
Ryan, JR
Wirtz, RA
Moulton, JK
Dave, K
Faulde, MK
AF Coleman, Russell E.
Hochberg, Lisa P.
Putnam, John L.
Swanson, Katherine I.
Lee, John S.
McAvin, James C.
Chan, Adeline S.
O'Guinn, Monica L.
Ryan, Jeffry R.
Wirtz, Robert A.
Moulton, John K.
Dave, Kirti
Faulde, Michael K.
TI Use of Vector Diagnostics During Military Deployments: Recent Experience
in Iraq and Afghanistan
SO MILITARY MEDICINE
LA English
DT Article
ID WEST-NILE-VIRUS; POLYMERASE-CHAIN-REACTION; PHLEBOTOMINE SAND FLIES;
ANTIGEN PANEL ASSAY; TALLIL AIR BASE; PLASMODIUM-FALCIPARUM; RAPID
DETECTION; ANOPHELINE MOSQUITOS; INDIVIDUAL MOSQUITOS;
INFECTIOUS-DISEASES
AB Vector-borne diseases such as malaria, dengue, and leishmaniasis are a threat to military forces deployed outside of the United States. The availability of specific information on the vector-borne disease threat (e.g., presence or absence of a specific disease agent, temporal and geographic distribution of competent vectors, and vector infection rates) allows or effective implementation of appropriate measures to protect our deployed military forces. Vector diagnostics can provide critical, real-time information crucial to establishing effective vector prevention/control programs. In this article we provide an overview of current vector diagnostic capabilities, evaluate the use of vector diagnostics in Operation Enduring Freedom and Operation Iraqi Freedom, and discuss the concept of operations under which vector diagnostics are employed.
C1 [Coleman, Russell E.; Hochberg, Lisa P.; Swanson, Katherine I.; Chan, Adeline S.; Ryan, Jeffry R.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA.
[Putnam, John L.; McAvin, James C.] USAF, Inst Operat Hlth, Epidemiol Surveillance Div, San Antonio, TX USA.
[Lee, John S.; O'Guinn, Monica L.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Wirtz, Robert A.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA USA.
[Dave, Kirti] VecTOR Test Syst Inc, Thousand Oaks, CA USA.
[Moulton, John K.] Univ Tennessee, Dept Entomol & Plant Pathol, Knoxville, TN 37901 USA.
[Faulde, Michael K.] Cent Inst Bundeswehr Med Serv, Dept Med Zool, Koblenz, Germany.
RP Coleman, RE (reprint author), Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA.
FU Military Infectious Diseases Research Program; Armed Forces Medical
Intelligence Center; Deployed War-Fighter Protection Program
FX Funding for this project was provided by the Military Infectious
Diseases Research Program, the Armed Forces Medical Intelligence Center,
and the Deployed War-Fighter Protection Program. Many thanks to LTC Bill
Sames for his review of this manuscript, and to LTC (Ret.) Richard
Lofts. COL David Craft, and Dr. Michael Turell for their guidance on
BSATs. This study would not have been possible without the support of
the many entomologists and environmental science officers conducting
vector surveillance throughout Iraq and Afghanistan. In addition, the
superb support of our laboratory technicians running the PCR assays is
greatly appreciated-thanks to Wayne and Lara Gilmore, Monzia Moodie,
Cathy Westbrook, and SGT Ronald Hadley.
NR 74
TC 7
Z9 7
U1 0
U2 5
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD SEP
PY 2009
VL 174
IS 9
BP 904
EP 920
PG 17
WC Medicine, General & Internal
SC General & Internal Medicine
GA 601LH
UT WOS:000278060400004
PM 19780365
ER
PT J
AU Botto, LD
Feuchtbaum, L
Dowray, S
Piper, KN
Romitti, PA
Wang, Y
Palmer, M
Olney, RS
Hinton, C
AF Botto, L. D.
Feuchtbaum, L.
Dowray, S.
Piper, K. Noble
Romitti, P. A.
Wang, Y.
Palmer, M.
Olney, R. S.
Hinton, C.
TI EVALUATING CLINICAL AND PUBLIC HEALTH OUTCOMES OF EXPANDED NEWBORN
SCREENING: A MULTI-STATE, POPULATION-BASED PILOT PROJECT
SO MOLECULAR GENETICS AND METABOLISM
LA English
DT Meeting Abstract
CT 11th International Conference of Inborn Errors of Metabolism
CY AUG 29-SEP 02, 2009
CL San Diego, CA
C1 [Botto, L. D.] Univ Utah, Div Med Genet, Salt Lake City, UT USA.
[Feuchtbaum, L.; Dowray, S.] Calif Dept Hlth Serv, Genet Dis Screening Program, Richmond, CA USA.
[Piper, K. Noble] Ctr Congenital & Inherited Disorders, Iowa Dept Publ Hlth, Iowa City, IA USA.
[Romitti, P. A.] Univ Iowa, Dept Epidemiol, Iowa City, IA USA.
[Wang, Y.] New York State Dept Hlth, New York State Congenital Malformat Registry, Troy, NY USA.
[Palmer, M.] Utah Dept Hlth, Utah Birth Defect Network, Salt Lake City, UT 84116 USA.
[Olney, R. S.; Hinton, C.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1096-7192
J9 MOL GENET METAB
JI Mol. Genet. Metab.
PD SEP-OCT
PY 2009
VL 98
IS 1-2
MA 538
BP 104
EP 104
PG 1
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
Medicine
GA 483DQ
UT WOS:000268942600437
ER
PT J
AU De Jesus, VR
Chace, DH
Lim, TH
Adam, BW
Mei, JV
Hannon, WH
AF De Jesus, V. R.
Chace, D. H.
Lim, T. H.
Adam, B. W.
Mei, J. V.
Hannon, W. H.
TI QUANTIFICATION OF MALONYLCARNITINE AND GLUTARYLCARNITINE IN DRIED-BLOOD
SPOTS VARY BY TANDEM MASS SPECTROMETRY METHOD
SO MOLECULAR GENETICS AND METABOLISM
LA English
DT Meeting Abstract
CT 11th International Conference of Inborn Errors of Metabolism
CY AUG 29-SEP 02, 2009
CL San Diego, CA
C1 [De Jesus, V. R.; Lim, T. H.; Adam, B. W.; Mei, J. V.; Hannon, W. H.] Ctr Dis Control & Prevent, Newborn Screening & Mol Biol Branch, Atlanta, GA USA.
[Chace, D. H.] Pediatrix Ctr Res & Educ, Sunrise, FL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1096-7192
J9 MOL GENET METAB
JI Mol. Genet. Metab.
PD SEP-OCT
PY 2009
VL 98
IS 1-2
MA 544
BP 105
EP 105
PG 1
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
Medicine
GA 483DQ
UT WOS:000268942600443
ER
PT J
AU Bodamer, OA
Dajnoki, A
Fekete, G
Keutzer, J
Orsini, J
De Jesus, V
Chien, N
Hwu, P
Lukase, Z
Zhang, K
Muhl, A
AF Bodamer, O. A.
Dajnoki, A.
Fekete, G.
Keutzer, J.
Orsini, J.
De Jesus, V.
Chien, N.
Hwu, P.
Lukase, Z.
Zhang, K.
Muhl, A.
TI NEWBORN SCREENING FOR FABRY DISEASE BY MEASURING GLA ACTIVITY USING
TANDEM MASS SPECTROMETRY
SO MOLECULAR GENETICS AND METABOLISM
LA English
DT Meeting Abstract
CT 11th International Conference of Inborn Errors of Metabolism
CY AUG 29-SEP 02, 2009
CL San Diego, CA
C1 [Bodamer, O. A.] Univ Childrens Hosp Salzburg, Salzburg, Austria.
[Dajnoki, A.; Fekete, G.] Univ Childrens Hosp Budapest, Budapest, Hungary.
[Keutzer, J.] Genzyme, Boston, MA USA.
[Orsini, J.] Wadsworth Ctr, Albany, NY USA.
[De Jesus, V.] CDC, Atlanta, GA 30333 USA.
[Chien, N.; Hwu, P.] Natl Childrens Hosp, Taipei, Taiwan.
[Lukase, Z.] Univ Childrens Hosp Hamburg, Hamburg, Germany.
[Zhang, K.] Genzyme, Framingham, MA USA.
[Muhl, A.] Centogene, Vienna, Austria.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1096-7192
J9 MOL GENET METAB
JI Mol. Genet. Metab.
PD SEP-OCT
PY 2009
VL 98
IS 1-2
MA 558
BP 108
EP 108
PG 1
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
Medicine
GA 483DQ
UT WOS:000268942600457
ER
PT J
AU Mei, JV
Meredith, NK
Bell, CJ
De Jesus, VR
Lim, TH
Adam, BW
Hannon, WH
AF Mei, J. V.
Meredith, N. K.
Bell, C. J.
De Jesus, V. R.
Lim, T. H.
Adam, B. W.
Hannon, W. H.
TI NEWBORN SCREENING BY TANDEM MASS SPECTROMETRY: HARMONIZATION OF PRACTICE
AND PERFORMANCE
SO MOLECULAR GENETICS AND METABOLISM
LA English
DT Meeting Abstract
CT 11th International Conference of Inborn Errors of Metabolism
CY AUG 29-SEP 02, 2009
CL San Diego, CA
C1 [Mei, J. V.; Meredith, N. K.; Bell, C. J.; De Jesus, V. R.; Lim, T. H.; Adam, B. W.; Hannon, W. H.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1096-7192
J9 MOL GENET METAB
JI Mol. Genet. Metab.
PD SEP-OCT
PY 2009
VL 98
IS 1-2
MA 603
BP 119
EP 119
PG 1
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
Medicine
GA 483DQ
UT WOS:000268942600502
ER
PT J
AU Klein, NP
Aukes, L
Lee, J
Fireman, B
Baxter, R
Shapira, SK
Summar, M
AF Klein, N. P.
Aukes, L.
Lee, J.
Fireman, B.
Baxter, R.
Shapira, S. K.
Summar, M.
TI EVALUATION OF IMMUNIZATION RATES AND SAFETY AMONG CHILDREN WITH INBORN
ERRORS OF METABOLISM
SO MOLECULAR GENETICS AND METABOLISM
LA English
DT Meeting Abstract
CT 11th International Conference of Inborn Errors of Metabolism
CY AUG 29-SEP 02, 2009
CL San Diego, CA
C1 [Klein, N. P.; Aukes, L.; Lee, J.; Fireman, B.; Baxter, R.] No Calif Kaiser Permanente, Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA.
[Shapira, S. K.] Ctr Dis Control & Prevent, NCBDDD, Atlanta, GA USA.
[Summar, M.] Vanderbilt Univ, Med Ctr, Ctr Human Genet Res, Nashville, TN USA.
[Summar, M.] Vanderbilt Univ, Med Ctr, Div Med Genet, Nashville, TN USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1096-7192
J9 MOL GENET METAB
JI Mol. Genet. Metab.
PD SEP-OCT
PY 2009
VL 98
IS 1-2
MA 660
BP 132
EP 132
PG 1
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
Experimental
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
Medicine
GA 483DQ
UT WOS:000268942600558
ER
PT J
AU Chapman, LE
AF Chapman, Louisa E.
TI Xenotransplantation, Xenogeneic Infections, Biotechnology, and Public
Health
SO MOUNT SINAI JOURNAL OF MEDICINE
LA English
DT Article
DE porcine endogenous virus; public health; xenogeneic infections;
xenotransplantation
ID PORCINE ENDOGENOUS RETROVIRUS; UNITED-STATES; NO EVIDENCE; TRANSMISSION;
CELLS; LIVER; RECIPIENTS; ZOONOSIS; BABOON; VIRUS
AB Xenotransplantation is the attempt to use living biological material from nonhuman animal species in humans for therapeutic purposes. Clinical trials and preclinical studies have suggested that living cells and tissue from other species have the potential to be used in humans to ameliorate disease. However, the potential for Successful xenotransplantation to cure human disease is coupled with the risk that therapeutic use of living nonhuman cells in humans may also serve to introduce xenogeneic infections of unpredictable significance. Animal husbandry practices and xenotransplantation product preparation may eliminate most exogenous infectious agents prior to transplantation. However, endogenous retroviruses are present in the genomes of all mammalian cells, have an inadequately defined ability to infect human cells, and have generated public health concern. The history of xenotransplantation, the implications for public health, the global consensus on public safeguards necessary to accompany clinical trials, and the future direction of xenotransplantation are discussed in the context of public health. Mt Sinai J Med 76-435-441, 2009. (C) 2009 Mount Sinai School of Medicine
C1 Ctr Dis Control & Prevent, Off Crit Informat Integrat & Exchange, Atlanta, GA 30333 USA.
RP Chapman, LE (reprint author), Ctr Dis Control & Prevent, Off Crit Informat Integrat & Exchange, Atlanta, GA 30333 USA.
EM lec3@cdc.gov
NR 30
TC 6
Z9 6
U1 0
U2 7
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0027-2507
J9 MT SINAI J MED
JI Mt. Sinai J. Med.
PD SEP-OCT
PY 2009
VL 76
IS 5
BP 435
EP 441
DI 10.1002/msj.20131
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA 504JK
UT WOS:000270612200005
PM 19787652
ER
PT J
AU Murhekar, M
Moolenaar, R
Hutin, Y
Broome, C
AF Murhekar, Manoj
Moolenaar, Ron
Hutin, Yvan
Broome, Claire
TI Investigating outbreaks: Practical guidance in the Indian scenario
SO NATIONAL MEDICAL JOURNAL OF INDIA
LA English
DT Article
ID WESTERN UTTAR-PRADESH; TRANSMISSION; CHILDREN; EPIDEMIOLOGY; DISEASE;
HEALTH
AB The new International Health Regulations, 2005, which came Into force in 2007, establish a national focal point in each country to manage public health emergencies of International concern, including outbreaks. Investigating outbreaks is a challenging task. Often, pressure from decision-makers to hasten investigation may preclude proper evidence-based conclusions. Furthermore, the task of outbreak investigation Is given to senior staff, who have limited time for field activities.
The classical 10-step approach includes 4 main stages of (i) confirmation of the presence of the outbreak and of diagnosis using laboratory tests, (ii) generation of hypotheses regarding causation using descriptive epidemiology findings, (iii) hypothesis-testing using analytical epidemiology techniques, and (iv) institution of prevention measures. Peer-review at all stages of the investigation and reporting is the keystone of the quality assurance process.
It is important to build capacity for outbreak investigation. Two Field Epidemiology Training Programmes in India are trying to do this. In these programmes, epidemiologists-in-training take a lead in investigating outbreaks, while learning the ropes, with full technical support from the faculty. This training should spawn a culture of generating and using evidence for decision-making in the context of public health, and help strengthen health systems even beyond the domain of outbreaks.
C1 [Murhekar, Manoj; Hutin, Yvan] Indian Council Med Res, NIE, FETP, Chennai 600077, Tamil Nadu, India.
[Moolenaar, Ron] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Hutin, Yvan] WHO India Country Off, New Delhi, India.
RP Murhekar, M (reprint author), Indian Council Med Res, NIE, FETP, R 127,3rd Ave,Tamil Nadu Housing Board,Phase 1, Chennai 600077, Tamil Nadu, India.
EM mmurhekar@gmail.com
NR 25
TC 1
Z9 1
U1 0
U2 0
PU ALL INDIA INST MEDICAL SCIENCES
PI NEW DELHI
PA ANSARI NAGAR, NEW DELHI 110 029, INDIA
SN 0970-258X
J9 NATL MED J INDIA
JI Natl. Med. J. India
PD SEP-OCT
PY 2009
VL 22
IS 5
BP 252
EP 256
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 534DA
UT WOS:000272874500007
PM 20334049
ER
PT J
AU Trevathan, E
Dietz, WH
AF Trevathan, Edwin
Dietz, William H.
TI Obesity in neurology practice: A call to action
SO NEUROLOGY
LA English
DT Editorial Material
ID OVERWEIGHT CHILDREN; ADOLESCENTS; WEIGHT
C1 [Trevathan, Edwin] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Dietz, William H.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
RP Trevathan, E (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,NE,Mailstop E-87, Atlanta, GA 30333 USA.
EM ETrevathan@cdc.gov
NR 10
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0028-3878
J9 NEUROLOGY
JI Neurology
PD SEP 1
PY 2009
VL 73
IS 9
BP 654
EP 655
PG 2
WC Clinical Neurology
SC Neurosciences & Neurology
GA 489SY
UT WOS:000269444200001
PM 19641167
ER
PT J
AU Finkel, R
Biggar, D
Bonnemann, C
Constantin, C
Escolar, D
Massey, E
Miller, T
Pascual, J
Sladky, J
Wagner, K
Wong, B
Bushby, K
AF Finkel, R.
Biggar, D.
Bonnemann, C.
Constantin, C.
Escolar, D.
Massey, E.
Miller, T.
Pascual, J.
Sladky, J.
Wagner, K.
Wong, B.
Bushby, K.
TI Use of glucocorticoids in Duchenne MD: Consensus report of the CDC
Duchenne care considerations neurology panel
SO NEUROMUSCULAR DISORDERS
LA English
DT Meeting Abstract
CT 14th International Congress of the World-Muscle-Society
CY SEP 09-12, 2009
CL Geneva, SWITZERLAND
SP World Muscle Soc
C1 [Finkel, R.; Bonnemann, C.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
[Biggar, D.] Bloorview Kids Rehab Hosp, Toronto, ON, Canada.
[Constantin, C.] Ctr Dis Control & Prevent, Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Escolar, D.] Childrens Natl Med Ctr, Washington, DC 20010 USA.
[Massey, E.] Duke Univ, Durham, NC 27706 USA.
[Miller, T.] Univ Arizona, Tucson, AZ 85721 USA.
[Pascual, J.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
[Sladky, J.] Emory Univ, Atlanta, GA 30322 USA.
[Wagner, K.] Johns Hopkins Med Inst, Baltimore, MD 21205 USA.
[Wong, B.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA.
[Bushby, K.] Univ Newcastle, Newcastle, NSW, Australia.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-8966
J9 NEUROMUSCULAR DISORD
JI Neuromusc. Disord.
PD SEP
PY 2009
VL 19
IS 8-9
BP 610
EP 610
DI 10.1016/j.nmd.2009.06.209
PG 1
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 491OW
UT WOS:000269589600206
ER
PT J
AU Bushby, K
Birnkrant, D
Case, L
Clemens, P
Cripe, L
Finkel, R
Kaul, A
Kinnett, K
McDonald, C
Pandya, S
Poysky, J
Shapiro, F
Tomezsko, J
Constantin, C
AF Bushby, K.
Birnkrant, D.
Case, L.
Clemens, P.
Cripe, L.
Finkel, R.
Kaul, A.
Kinnett, K.
McDonald, C.
Pandya, S.
Poysky, J.
Shapiro, F.
Tomezsko, J.
Constantin, C.
TI The diagnosis and management of Duchenne muscular dystrophy:
Internationally generated care recommendations
SO NEUROMUSCULAR DISORDERS
LA English
DT Meeting Abstract
CT 14th International Congress of the World-Muscle-Society
CY SEP 09-12, 2009
CL Geneva, SWITZERLAND
SP World Muscle Soc
C1 [Bushby, K.] Univ Newcastle, Newcastle Upon Tyne, Tyne & Wear, England.
[Birnkrant, D.] MetroHlth Ctr, Cleveland, OH USA.
[Case, L.] Duke Univ, Durham, NC 27706 USA.
[Clemens, P.] Univ Pittsburgh, Pittsburgh, PA USA.
[Cripe, L.; Kaul, A.; Kinnett, K.] Cincinnati Childrens Hosp, Cincinnati, OH USA.
[Finkel, R.; Tomezsko, J.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
[McDonald, C.] Univ Calif Davis, Davis, CA 95616 USA.
[Pandya, S.] Univ Rochester, Rochester, NY 14627 USA.
[Shapiro, F.] Childrens Hosp Boston, Boston, MA USA.
[Constantin, C.] Ctr Dis Control, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-8966
J9 NEUROMUSCULAR DISORD
JI Neuromusc. Disord.
PD SEP
PY 2009
VL 19
IS 8-9
BP 640
EP 641
DI 10.1016/j.nmd.2009.06.300
PG 2
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 491OW
UT WOS:000269589600297
ER
PT J
AU Petersen, MR
Deddens, JA
AF Petersen, M. R.
Deddens, J. A.
TI A revised SAS macro for maximum likelihood estimation of prevalence
ratios using the COPY method
SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Letter
C1 [Petersen, M. R.; Deddens, J. A.] NIOSH, Cincinnati, OH 45226 USA.
[Deddens, J. A.] Univ Cincinnati, Dept Math Sci, Cincinnati, OH 45221 USA.
RP Petersen, MR (reprint author), NIOSH, Mail Stop R15,4676 Columbia Pkwy, Cincinnati, OH 45226 USA.
EM mrp1@one.net
NR 5
TC 4
Z9 4
U1 0
U2 1
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1351-0711
J9 OCCUP ENVIRON MED
JI Occup. Environ. Med.
PD SEP
PY 2009
VL 66
IS 9
BP 639
EP 639
DI 10.1136/oem.2008.043018
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 484RA
UT WOS:000269063400013
PM 19690158
ER
PT J
AU Allen, KD
Helmick, CG
Schwartz, TA
DeVellis, RF
Renner, JB
Jordan, JM
AF Allen, K. D.
Helmick, C. G.
Schwartz, T. A.
DeVellis, R. F.
Renner, J. B.
Jordan, J. M.
TI Racial differences in self-reported pain and function among individuals
with radiographic hip and knee osteoarthritis: the Johnston County
Osteoarthritis Project
SO OSTEOARTHRITIS AND CARTILAGE
LA English
DT Article
DE Osteoarthritis; Pain; Function; Race
ID AFRICAN-AMERICANS; OLDER-ADULTS; SYMPTOMS; DISABILITY; COMMUNITY;
ARTHRITIS; SEVERITY; OBESITY; HEALTH; WOMAC
AB Objective: This study compared pain and function among African Americans and Caucasian with radiographic hip and/or knee osteoarthritis (OA), controlling for radiographic severity and other patient characteristics.
Methods: Participants were 1368 individuals (32% African American) from the Johnston County Osteoarthritis Project with only knee OA, only hip OA, and both knee and hip OA. Linear regression models examined racial differences in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total scores and pain and function subscales, adjusting for radiographic severity, age, gender, education, body mass index (BMI), depressive symptoms, and WOMAC pain (last variable in models of function).
Results: Among those with only knee OA, African Americans had significantly worse mean WOMAC total scores than Caucasian (32.8 vs 24.3, P< 0.001), and worse pain and function scores (P < 0.001). Racial differences in WOMAC total, pain, and function scores persisted when controlling for radiographic severity and demographic factors but were not significant when also controlling for BMI and depressive symptoms. In models of WOMAC function, pain was the most strongly associated variable and substantially reduced the association of race with function. There were no racial differences in WOMAC scores among those with only hip OA or with both knee and hip OA.
Conclusion: Among participants with knee OA, racial differences in pain and function may be explained by BMI and depressive symptoms, and racial differences in function may also be largely influenced by pain. Improving management of weight and depressive symptoms may be key steps toward reducing racial disparities in knee OA symptoms. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.
C1 [Allen, K. D.] Durham Vet Affairs Med Ctr, Hlth Serv Res & Dev Serv, Durham, NC USA.
[Allen, K. D.] Duke Univ, Med Ctr, Div Gen Internal Med, Dept Med, Durham, NC 27710 USA.
[Helmick, C. G.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Schwartz, T. A.; DeVellis, R. F.; Renner, J. B.; Jordan, J. M.] Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA.
[Schwartz, T. A.] Univ N Carolina, Dept Biostat, Chapel Hill, NC USA.
[DeVellis, R. F.] Univ N Carolina, Dept Hlth Behav & Hlth Educ, Chapel Hill, NC USA.
[Renner, J. B.] Univ N Carolina, Dept Radiol, Chapel Hill, NC USA.
[Jordan, J. M.] Univ N Carolina, Dept Med, Chapel Hill, NC USA.
[Jordan, J. M.] Univ N Carolina, Dept Orthopaed, Chapel Hill, NC USA.
RP Allen, KD (reprint author), VA Med Ctr, HSR&D 152, 508 Fulton St, Durham, NC 27705 USA.
EM kelli.allen@duke.edu
RI Schwartz, Todd/D-4995-2012
OI Schwartz, Todd/0000-0002-0232-2543
FU Centers for Disease Control and Prevention/Association of Schools of
Public Health [S1734, S3486]; NIAMS Multipurpose Arthritis and
Musculoskeletal Disease Center [5-P60-AR30701, 5 P60 AR49465-03]
FX The findings and conclusions in this report are those of the authors and
do not necessarily represent the official position of the Centers for
Disease Control and Prevention or the Department of Veterans Affairs.
Funding was made possible (in part) by: cooperative agreements S1734 and
S3486 from the Centers for Disease Control and Prevention/Association of
Schools of Public Health, the NIAMS Multipurpose Arthritis and
Musculoskeletal Disease Center grant 5-P60-AR30701, and the NIAMS
Multidisciplinary Clinical Research Center grant-5 P60 AR49465-03.
NR 26
TC 34
Z9 35
U1 0
U2 1
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1063-4584
J9 OSTEOARTHR CARTILAGE
JI Osteoarthritis Cartilage
PD SEP
PY 2009
VL 17
IS 9
BP 1132
EP 1136
DI 10.1016/j.joca.2009.03.003
PG 5
WC Orthopedics; Rheumatology
SC Orthopedics; Rheumatology
GA 498EA
UT WOS:000270118500002
PM 19327733
ER
PT J
AU Simpson, GA
Cohen, RA
Bloom, B
Blumberg, SJ
AF Simpson, Gloria A.
Cohen, Robin A.
Bloom, Barbara
Blumberg, Stephen J.
TI The impact of children's emotional and behavioural difficulties on their
lives and their use of mental health services
SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
LA English
DT Article
DE emotional difficulties; child behaviour; ethnic group; mental health
services; family burden
ID QUALITY-OF-LIFE; PSYCHOMETRIC PROPERTIES; PSYCHIATRIC-DISORDERS;
QUESTIONNAIRE; STRENGTHS; PARENTS; CARE; ADOLESCENTS; HYPERACTIVITY;
PERCEPTION
AB This paper examines the relationship between the impact of children's emotional and behavioural difficulties and the use of mental health services, using 3 years of nationally representative data from the National Health Interview Survey. Data for the years 2001, 2003 and 2004 were combined (n = 29 265) to identify a sample of 1423 children aged 4-17 years with emotional/behavioural difficulties. Multivariable logistic regression analysis was used.
About 5% of U.S. children had emotional or behavioural difficulties. Children whose difficulty was a burden on their family were almost twice as likely to have contact with a mental health professional. Younger children (aged 4-7 years), Hispanic children and non-Hispanic black children with emotional or behavioural difficulties were less likely to use mental health services. These findings indicate that children's emotional and behavioural difficulties influence their lives and those of their families, leading parents to seek help. Racial disparities in mental health service use exist when controlling for the severity and the burden of these difficulties.
C1 [Cohen, Robin A.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Hlth Interview Stat, Hyattsville, MD 20782 USA.
RP Cohen, RA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Hlth Interview Stat, 3311 Toledo Rd,Room 2335, Hyattsville, MD 20782 USA.
EM rzc6@cdc.gov
NR 48
TC 9
Z9 10
U1 4
U2 6
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0269-5022
J9 PAEDIATR PERINAT EP
JI Paediatr. Perinat. Epidemiol.
PD SEP
PY 2009
VL 23
IS 5
BP 472
EP 481
DI 10.1111/j.1365-3016.2009.01043.x
PG 10
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
Pediatrics
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
Pediatrics
GA 479LA
UT WOS:000268659600011
PM 19689498
ER
PT J
AU Rubin, C
Maisonet, M
Kieszak, S
Monteilh, C
Holmes, A
Flanders, D
Heron, J
Golding, J
McGeehin, M
Marcus, M
AF Rubin, Carol
Maisonet, Mildred
Kieszak, Stephanie
Monteilh, Carolyn
Holmes, Adrianne
Flanders, Dana
Heron, Jon
Golding, Jean
McGeehin, Mike
Marcus, Michele
TI Timing of maturation and predictors of menarche in girls enrolled in a
contemporary British cohort
SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
LA English
DT Article
DE puberty; menarche; ALSPAC; Tanner stages; maternal menarche; maternal
smoking; maternal BMI
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; BODY-MASS INDEX;
PUBERTAL DEVELOPMENT; SEXUAL-MATURATION; SELF-ASSESSMENT; US GIRLS;
POLYCHLORINATED-BIPHENYLS; SECULAR TRENDS; AGE
AB This study describes the timing of puberty in 8- to 13-year-old girls enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC) and identifies factors associated with earlier achievement of menarche. Women were enrolled during pregnancy and their offspring were followed prospectively. We analysed self-reported Tanner staging and menstrual status information collected annually from daughters up to age 13. We used survival models to estimate median age of attainment of stage > 1 and stage > 2 of breast and pubic hair development and of menarche. We also constructed multivariable logistic regression models to identify factors associated with earlier achievement of menarche.
About 12% of girls reported Tanner breast stage > 1 at age 8; 98% of girls were above stage 1 by age 13. For pubic hair, 5% and 95% of girls had attained a stage > 1 by 8 and 13 years, respectively. The estimated median age of entry into stage > 1 of breast development was 10.14 years (95% confidence interval [CI], 10.08, 10.19), and for pubic hair development the median age was 10.92 years [95% CI, 10.87, 10.97]. One girl (out of 2953) had attained menarche by age 8; 60% had attained menarche by age 13. The estimated median age at menarche was 12.93 years [95% CI, 12.89, 12.98]. Prenatal predictors of menarche by age 11 (12% of girls) included earlier maternal age at menarche, high maternal pre-pregnancy body mass index, smoking during the third trimester, and non-white race; the single postnatal predictor was the girl's body size at 8 years. Age at attainment of breast and pubic hair Tanner stage and age at menarche in the ALSPAC cohort are similar to ages reported in other European studies that were conducted during overlapping time periods. The results also give added support to the strong influence of maternal maturation, pre-adolescent body size and race on the timing of a girl's menarche. This cohort will continue to be followed for maturational information until age 17.
C1 [Maisonet, Mildred; Flanders, Dana; Marcus, Michele] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Rubin, Carol; Maisonet, Mildred; Kieszak, Stephanie; Monteilh, Carolyn; Holmes, Adrianne; Flanders, Dana; McGeehin, Mike; Marcus, Michele] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Heron, Jon] Univ Bristol, Dept Social Med, Bristol, Avon, England.
[Golding, Jean] Univ Bristol, Dept Community Based Med, Ctr Child & Adolescent Hlth, Bristol, Avon, England.
RP Marcus, M (reprint author), Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, 1518 Clifton Rd NE, Atlanta, GA 30322 USA.
EM mmarcus@sph.emory.edu
RI Marcus, Michele/J-2746-2015; Heron, Jon/D-5884-2011;
OI Heron, Jon/0000-0001-6199-5644; Maisonet, Mildred/0000-0003-3561-2632;
Golding, Jean/0000-0003-2826-3307
FU Centers for Disease Control and Prevention
FX We are extremely grateful to all the families who took part in this
study, the midwives for their help in recruiting them, and the whole
ALSPAC team, which includes interviewers, computer and laboratory
technicians, clerical workers, research scientists, volunteers,
managers, receptionists and nurses. The UK Medical Research Council, the
Wellcome Trust and the University of Bristol currently provide core
support for ALSPAC. This publication is the work of the authors and they
will serve as guarantors for the contents of this paper. This research
was specifically funded by Centers for Disease Control and Prevention.
NR 56
TC 51
Z9 52
U1 3
U2 8
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0269-5022
J9 PAEDIATR PERINAT EP
JI Paediatr. Perinat. Epidemiol.
PD SEP
PY 2009
VL 23
IS 5
BP 492
EP 504
DI 10.1111/j.1365-3016.2009.01055.x
PG 13
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
Pediatrics
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
Pediatrics
GA 479LA
UT WOS:000268659600013
PM 19689500
ER
PT J
AU Liu, AQ
Wang, RJ
Li, YH
Zhang, LX
Shu, J
Zhang, WZ
Feng, YY
Xiao, LH
Ling, H
AF Liu, Aiqin
Wang, Rongjun
Li, Yihong
Zhang, Longxian
Shu, Jing
Zhang, Weizhe
Feng, Yaoyu
Xiao, Lihua
Ling, Hong
TI Prevalence and distribution of Cryptosporidium spp. in dairy cattle in
Heilongjiang Province, China
SO PARASITOLOGY RESEARCH
LA English
DT Article
ID N. SP APICOMPLEXA; EASTERN UNITED-STATES; DEER-LIKE GENOTYPE;
BOS-TAURUS; FARM-ANIMALS; IDENTIFICATION; ANDERSONI; BOVIS; PARASITES;
DIARRHEA
AB Few data are available on the molecular characterization of Cryptosporidium spp. in cattle in China. In the present study, a total of 507 fecal specimens from six dairy farms in Heilongjiang Province were examined for Cryptosporidium spp. by light microscopy of concentrates from the formalin-ethyl acetate sedimentation method (for less than 2-month-old calves) or Sheather's floatation method (more than 3-month-old dairy cattle). Twenty-seven post-weaned calves on five farms were positive for Cryptosporidium oocysts. PCR and DNA sequence analysis of the 18S rRNA, actin, and 70 kDa heat shock protein genes identified Cryptosporidium andersoni and Cryptosporidium. ryanae, with C. andersoni as the dominant species (26 out of 27). In comparison with other regions of the world, the distribution of Cryptosporidium species in the areas appears to be unique.
C1 [Liu, Aiqin; Li, Yihong; Shu, Jing; Zhang, Weizhe; Ling, Hong] Harbin Med Coll, Dept Parasitol, Harbin 150081, Heilongjiang, Peoples R China.
[Wang, Rongjun; Zhang, Longxian] Henan Agr Univ, Coll Anim Sci & Vet Med, Zhengzhou 450002, Henan, Peoples R China.
[Feng, Yaoyu] E China Univ Sci & Technol, Sch Resource & Environm Engn, Shanghai 200237, Peoples R China.
[Xiao, Lihua] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30341 USA.
RP Ling, H (reprint author), Harbin Med Coll, Dept Parasitol, 194 Xuefu Rd, Harbin 150081, Heilongjiang, Peoples R China.
EM lingh@ems.hrbmu.edu.cn
RI Xiao, Lihua/B-1704-2013; Feng, Yaoyu/B-3076-2014
OI Xiao, Lihua/0000-0001-8532-2727;
FU Natural Science Foundation of Heilongjiang Province [D200628)];
Heilongjiang Province Education Bureau [11521082]
FX This work was supported in part by the Natural Science Foundation of
Heilongjiang Province (grant D200628) and the Heilongjiang Province
Education Bureau (grant 11521082), China. We thank YL Jin at
Heilongjiang Animal Health Inspection Institute for help in providing
the specimens.
NR 49
TC 26
Z9 34
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0932-0113
J9 PARASITOL RES
JI Parasitol. Res.
PD SEP
PY 2009
VL 105
IS 3
BP 797
EP 802
DI 10.1007/s00436-009-1457-2
PG 6
WC Parasitology
SC Parasitology
GA 474WG
UT WOS:000268314400025
PM 19424720
ER
PT J
AU Hendriksen, RS
Mikoleit, M
Kornschober, C
Rickert, RL
Van Duyne, S
Kjelso, C
Hasman, H
Cormican, M
Mevius, D
Threlfall, J
Angulo, FJ
Aarestrup, FM
AF Hendriksen, Rene S.
Mikoleit, Matthew
Kornschober, Christian
Rickert, Regan L.
Van Duyne, Susan
Kjelso, Charlotte
Hasman, Henrik
Cormican, Martin
Mevius, Dik
Threlfall, John
Angulo, Frederic J.
Aarestrup, Frank M.
TI Emergence of Multidrug-Resistant Salmonella Concord Infections in Europe
and the United States in Children Adopted From Ethiopia, 2003-2007
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
DE Salmonella; Ethiopia; adoptees; ESBL; multi-drug resistance
ID SEROTYPE TYPHIMURIUM; STRAINS; FRANCE
AB Background: Multidrug-resistant Salmonella serovar Concord infections have been reported from children adopted from Ethiopia. We interviewed patients, characterized the isolates, and gathered information about adoptions from Ethiopia to assess public health implications.
Methods: Information about Salmonella Concord cases and adoptions were provided from Austria, Denmark, England (and Wales), Ireland, the Netherlands and the United States. Patients from Denmark and the United States were interviewed to determine the orphanages of origin; orphanages in Ethiopia were visited. Isolates were subtyped by pulsed-field gel electrophoresis and antimicrobial susceptibility; specific antimicrobial resistance genes were characterized.
Results: Salmonella Concord was isolated from 78 persons from 2003 to 2007. Adoption status was known for 44 patients <= 3 years of age; 98% were adopted from Ethiopia. The children adopted from Ethiopia were from several orphanages; visited orphanages had poor hygiene and sanitation and frequent use of antimicrobial agents. The number of children adopted from Ethiopia in the participating countries increased 527% from 221 in 2003 to 1385 in 2007. Sixty-four Salmonella Concord isolates yielded 53 pulsed-field gel electrophoresis patterns including 6 patterns with >2 indistinguishable isolates; one isolate from an Ethiopia adoptee. Antimicrobial susceptibility was per-formed on 43 isolates; 81% were multidrug-resistant (>= 3 agents). Multidrug-resistant isolates were from Ethiopian adoptees and were resistant to third and fourth generation cephalosporins and 14% had decreased susceptibility to ciprofloxacin.
Conclusions: Improved hygiene and sanitation and more appropriate use of antimicrobial agents are needed in orphanages in Ethiopia. Culturing of stool specimens of children adopted from Ethiopia and appropriate hygiene may prevent further disease transmission.
C1 [Hendriksen, Rene S.; Hasman, Henrik; Aarestrup, Frank M.] Tech Univ Denmark, Natl Food Inst, WHO Collaborating Ctr Antimicrobial Resistance Fo, DK-1790 Copenhagen V, Denmark.
[Hendriksen, Rene S.; Hasman, Henrik; Aarestrup, Frank M.] Tech Univ Denmark, Natl Food Inst, EU Community Reference Lab Antimicrobial Resistan, DK-1790 Copenhagen, Denmark.
[Mikoleit, Matthew; Rickert, Regan L.; Van Duyne, Susan; Angulo, Frederic J.] Ctr Dis Control & Prevent, WHO Collaborating Ctr Surveillance Epidemiol & Co, Atlanta, GA USA.
[Kornschober, Christian] Inst Med Microbiol & Hyg, Graz, Austria.
[Kjelso, Charlotte] Statens Serum Inst, DK-2300 Copenhagen, Denmark.
[Cormican, Martin] Natl Univ Ireland, Galway, Ireland.
[Mevius, Dik] Wageningen UR, Cent Vet Inst, Lelystad, Netherlands.
[Mevius, Dik] Univ Utrecht, Dept Immunol & Infect Dis, Utrecht, Netherlands.
[Threlfall, John] Ctr Infect, Dept Gastrointestinal Emerging & Zoonot Infect, London, England.
RP Hendriksen, RS (reprint author), Tech Univ Denmark, Natl Food Inst, WHO Collaborating Ctr Antimicrobial Resistance Fo, Bulowsvej 27, DK-1790 Copenhagen V, Denmark.
EM rshe@food.dtu.dk
OI Mikoleit, Matthew/0000-0002-4582-6733
FU Danish Research Agency [274-05-0117]
FX Supported by the World Health Organization Global Salm-Surv (available
at: www.who.int/salmsurv) and grant 274-05-0117 from the Danish Research
Agency.
NR 24
TC 30
Z9 30
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0891-3668
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD SEP
PY 2009
VL 28
IS 9
BP 814
EP 818
DI 10.1097/INF.0b013e3181a3aeac
PG 5
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA 489GF
UT WOS:000269407500012
PM 19710587
ER
PT J
AU Menzies, NA
Homsy, J
Pitter, JYC
Pitter, C
Mermin, J
Downing, R
Finkbeiner, T
Obonyo, J
Kekitiinwa, A
Tappero, J
Blandford, JM
AF Menzies, Nicolas A.
Homsy, Jaco
Pitter, Jeannie Y. Chang
Pitter, Christian
Mermin, Jonathan
Downing, Robert
Finkbeiner, Thomas
Obonyo, John
Kekitiinwa, Adeodata
Tappero, Jordan
Blandford, John M.
TI Cost-Effectiveness of Routine Rapid Human Immunodeficiency Virus
Antibody Testing Before DNA-PCR Testing for Early Diagnosis of Infants
in Resource-Limited Settings
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
DE HIV; early infant diagnosis; rapid testing; DNA PCR; cost-effectiveness;
Uganda; Africa
ID POLYMERASE-CHAIN-REACTION; TO-CHILD TRANSMISSION; HIV TRANSMISSION;
SOUTH-AFRICA; BLOOD SPOTS; INFECTION; PREVENTION; TYPE-1; AMPLIFICATION;
COMBINATION
AB Background: Infants born to HIV-infected women should receive HIV testing to allow early diagnosis and treatment. Recommendations for resource-limited settings stress laboratory-based virologic assays. While effective, these tests are logistically complex and expensive. This study explored the cost-effectiveness of incorporating initial screening with rapid HIV tests (RHT) into the conventional testing algorithm to screen-out HIV-uninfected infants, thereby reducing the need for costly virologic testing.
Methods: Data on HIV prevalence, RHT sensitivity and specificity, and costs were collected from 820 HIV-exposed children (1.5-18 months) attending 2 postnatal screening programs in Uganda during July 2005 to December 2006. Cost-effectiveness models compared the conventional testing algorithm DNA polymerase chain reaction (DNA-PCR with Roche Amplicor v1.5) with a modified algorithm (initial RHT to screen-out HIV-uninfected infants before DNA-PCR).
Results: The model estimated that the conventional algorithm would identify 94.3% (91.8%-94.7%) of HIV-infected infants, compared with 87.8% (79.4%-90.5%) for a modified algorithm using RHT (HIV 1/2 Determine) and excluding the need for DNA-PCR for HIV antibody-negative infants. Costs per infant were $23.47 ($23.32-$23.76) for the conventional algorithm and between $22.75 ($21.89-$23.31) and $7.58 ($6.41-$10.75) for the modified algorithm, depending on infant age and symptoms. Compared with the conventional algorithm, costs per HIV-infected infant identified using the modified algorithm were higher in 1.5- to 3-month-old infants, but significantly lower in 3-month-old and older infants. Models replicating the whole infant testing program showed the modified algorithm would have marginally lower sensitivity, but would reduce total program costs by 27% to 40%, producing an incremental cost-effectiveness ratio of $1489 ($686-$6781) for the conventional versus modified algorithms.
Conclusions: Screening infants with RHT before DNA-PCR is cost-effective in infants 3 months old or older. Incorporating RI-IT into early infant testing programs could improve cost-effectiveness and reduce program costs.
C1 [Menzies, Nicolas A.] Harvard Univ, Hlth Policy Program, Cambridge, MA 02138 USA.
[Menzies, Nicolas A.; Blandford, John M.] Ctr Dis Control & Prevent, Global AIDS Program, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA.
[Menzies, Nicolas A.] Macro Int Inc, Atlanta, GA USA.
[Homsy, Jaco; Downing, Robert; Tappero, Jordan] Uganda Virus Res Inst, CDC Uganda, Global AIDS Program, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Entebbe, Uganda.
[Homsy, Jaco; Pitter, Christian] Univ Calif San Francisco, Inst Global Hlth, San Francisco, CA 94143 USA.
[Pitter, Jeannie Y. Chang] Childrens Natl Med Ctr, Goldberg Ctr Community Pediat Hlth, Washington, DC 20010 USA.
[Pitter, Christian] Elizabeth Glaser Pediat AIDS Fdn, Washington, DC USA.
[Pitter, Christian] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA.
[Mermin, Jonathan] CDC Kenya, Coordinating Off Global Hlth, Nairobi, Kenya.
[Finkbeiner, Thomas] CDC Tanzania, Global AIDS Program, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Dar Es Salaam, Tanzania.
[Obonyo, John] Tororo Dist Hosp, Tororo, Uganda.
[Kekitiinwa, Adeodata] Childrens Fdn Uganda, Baylor Coll Med, Kampala, Uganda.
RP Menzies, NA (reprint author), Harvard Univ, Hlth Policy Program, 14 Story St, Cambridge, MA 02138 USA.
EM nmenzies@fas.harvard.edu
RI Mermin, Jonathan/J-9847-2012
NR 41
TC 16
Z9 16
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0891-3668
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD SEP
PY 2009
VL 28
IS 9
BP 819
EP 825
DI 10.1097/INF.0b013e3181a3954b
PG 7
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA 489GF
UT WOS:000269407500013
PM 20050391
ER
PT J
AU Yori, PP
Schwab, K
Gilman, RH
Nappier, S
Portocarrero, DV
Black, RE
Olortegui, MP
Hall, ER
Moe, C
Leon, J
Cama, VA
Kosek, M
AF Yori, Pablo Penataro
Schwab, Kellogg
Gilman, Robert H.
Nappier, Sharon
Velasquez Portocarrero, Daniel
Black, Robert E.
Paredes Olortegui, Maribel
Hall, Eric R.
Moe, Christine
Leon, Juan
Cama, Vita A.
Kosek, Margaret
TI NOROVIRUS HIGHLY PREVALENT CAUSE OF ENDEMIC ACUTE DIARRHEA IN CHILDREN
IN THE PERUVIAN AMAZON
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
DE norovirus; diarrhea; calicivirus
ID CHI-MINH-CITY; SPORADIC GASTROENTERITIS; HUMAN CALICIVIRUSES; NORWALK
VIRUS; ROTAVIRUS; INFECTIONS; ASSAY; PCR
AB To determine the burden of norovirus infections in children stools from a longitudinal community cohort were evaluated using reverse transcription polymerase chain reaction. Norovirus was detected in 21.3% of diarrheal and 8.0% of nondiarrheal stools (P < 0.01). Norovirus diarrhea was highly associated with age and the odds ratio for norovirus diarrhea fell by 2.8% per month (OR = 0.97, 95% CI: 0.95-0.99). Norovirus seems to be an important etiology of community acquired diarrhea in this study population.
C1 [Yori, Pablo Penataro; Gilman, Robert H.; Black, Robert E.; Kosek, Margaret] Johns Hopkins Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA.
[Schwab, Kellogg; Nappier, Sharon] Johns Hopkins Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA.
[Velasquez Portocarrero, Daniel; Paredes Olortegui, Maribel] Asocac Benef PRISMA, Lima, Peru.
[Moe, Christine] Emory Univ, Dept Int Hlth, Atlanta, GA 30322 USA.
[Hall, Eric R.] Naval Med Res Detachment, Lima, Peru.
[Leon, Juan; Cama, Vita A.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA.
RP Kosek, M (reprint author), Johns Hopkins Sch Publ Hlth, Dept Int Hlth, 615 Wolfe St W5515, Baltimore, MD 21205 USA.
EM mkosek@jhsph.edu
RI Moe, Christine/G-6118-2012; Leon, Juan/E-9674-2012;
OI Black, Robert/0000-0001-9926-7984
FU National Institutes of Health [K01-TW05717]; Global Emerging Infections
Surveillance and Response System [847705 82000 25GB B0016]
FX This study was funded by National Institutes of Health grant K01-TW05717
(MK), the Grand Challenges in Health Initiative
http://www.grandchallengesgh.org/, and the Global Emerging Infections
Surveillance and Response System work unit number 847705 82000 25GB
B0016.
NR 15
TC 16
Z9 18
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0891-3668
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD SEP
PY 2009
VL 28
IS 9
BP 844
EP 847
DI 10.1097/INF.0b013e3181a24730
PG 4
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA 489GF
UT WOS:000269407500021
PM 19636281
ER
PT J
AU Kumar, J
Muntner, P
Kaskel, FJ
Hailpern, SM
Melamed, ML
AF Kumar, Juhi
Muntner, Paul
Kaskel, Frederick J.
Hailpern, Susan M.
Melamed, Michal L.
TI Prevalence and Associations of 25-Hydroxyvitamin D Deficiency in US
Children: NHANES 2001-2004
SO PEDIATRICS
LA English
DT Article
DE rickets; vitamin D; cardiovascular risk factors; obesity; racial
disparities
ID VITAMIN-D DEFICIENCY; HIGH-DENSITY-LIPOPROTEIN; HYPOVITAMINOSIS-D;
AFRICAN-AMERICAN; BLOOD-PRESSURE; NUTRITIONAL RICKETS; D INSUFFICIENCY;
OBESE CHILDREN; UNITED-STATES; ADOLESCENTS
AB OBJECTIVES: To determine the prevalence of 25-hydroxyvitamin D (25[OH] D) deficiency and associations between 25(OH) D deficiency and cardiovascular risk factors in children and adolescents.
METHODS: With a nationally representative sample of children aged 1 to 21 years in the National Health and Nutrition Examination Survey 2001-2004 (n = 6275), we measured serum 25(OH) D deficiency and insufficiency (25[OH] D < 15 ng/mL and 15-29 ng/mL, respectively) and cardiovascular risk factors.
RESULTS: Overall, 9% of the pediatric population, representing 7.6 million US children and adolescents, were 25(OH) D deficient and 61%, representing 50.8 million US children and adolescents, were 25(OH) D insufficient. Only 4% had taken 400 IU of vitamin D per day for the past 30 days. After multivariable adjustment, those who were older (odds ratio [OR]: 1.16 [95% confidence interval (CI): 1.12 to 1.20] per year of age), girls (OR: 1.9 [1.6 to 2.4]), non-Hispanic black (OR: 21.9 [13.4 to 35.7]) or Mexican-American (OR: 3.5 [1.9 to 6.4]) compared with non-Hispanic white, obese (OR: 1.9 [1.5 to 2.5]), and those who drank milk less than once a week (OR: 2.9 [2.1 to 3.9]) or used >4 hours of television, video, or computers per day (OR: 1.6 [1.1 to 2.3]) were more likely to be 25(OH) D deficient. Those who used vitamin D supplementation were less likely (OR: 0.4 [0.2 to 0.8]) to be 25(OH) D deficient. Also, after multivariable adjustment, 25(OH) D deficiency was associated with elevated parathyroid hormone levels (OR: 3.6; [1.8 to 7.1]), higher systolic blood pressure (OR: 2.24mm Hg [0.98 to 3.50 mm Hg]), and lower serum calcium (OR:-0.10 mg/dL [-0.15 to-0.04 mg/dL]) and high-density lipoprotein cholesterol (OR: -3.03 mg/dL [-5.02 to-1.04]) levels compared with those with 25(OH) D levels >= 30 ng/mL.
CONCLUSIONS: 25(OH) D deficiency is common in the general US pediatric population and is associated with adverse cardiovascular risks. Pediatrics 2009; 124: e362-e370
C1 [Kumar, Juhi; Kaskel, Frederick J.] Childrens Hosp Montefiore, Bronx, NY USA.
[Melamed, Michal L.] Albert Einstein Coll Med, Dept Med & Epidemiol, Bronx, NY 10467 USA.
[Melamed, Michal L.] Albert Einstein Coll Med, Dept Populat Hlth, Bronx, NY 10467 USA.
[Muntner, Paul] Mt Sinai Sch Med, Dept Med, New York, NY USA.
[Hailpern, Susan M.] Ctr Dis Control & Prevent, Northrop Grumman & Div Diabet Translat, Atlanta, GA USA.
RP Melamed, ML (reprint author), 1300 Morris Pk Ave,Ullman 615,Belfer 1008, Bronx, NY 10461 USA.
EM mmelamed@aecom.yu.edu
FU National Institute of Diabetes and Digestive and Kidney Diseases [K23
078774]; National Institutes of Health; [T32 DK007110-33]; [U01
DK63549]; [U01 DK066174]
FX Dr Kumar is supported by grant T32 DK007110-33; Dr Kaskel is supported
by grants T32 DK007110-33, U01 DK63549, and U01 DK066174; and Dr Melamed
is supported by grant K23 078774, all from the National Institute of
Diabetes and Digestive and Kidney Diseases, National Institutes of
Health.
NR 40
TC 210
Z9 216
U1 1
U2 13
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD SEP
PY 2009
VL 124
IS 3
BP E362
EP E370
DI 10.1542/peds.2009-0051
PG 9
WC Pediatrics
SC Pediatrics
GA 488XH
UT WOS:000269383100023
PM 19661054
ER
PT J
AU Dietz, WH
Story, MT
Leviton, LC
AF Dietz, William H.
Story, Mary T.
Leviton, Laura C.
TI Introduction to Issues and Implications of Screening, Surveillance, and
Reporting of Children's BMI
SO PEDIATRICS
LA English
DT Editorial Material
DE child overweight; adolescent overweight; body mass index; BMI;
screening; surveillance
C1 [Dietz, William H.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA.
[Story, Mary T.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
[Leviton, Laura C.] Robert Wood Johnson Fdn, Princeton, NJ 08540 USA.
RP Dietz, WH (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, 4770 Buford Hwy NE,Mailstop K-24, Atlanta, GA 30341 USA.
EM wcd4@cdc.gov
NR 0
TC 8
Z9 8
U1 0
U2 0
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD SEP
PY 2009
VL 124
BP S1
EP S2
DI 10.1542/peds.2008-3586C
PG 2
WC Pediatrics
SC Pediatrics
GA 500CS
UT WOS:000270275400001
PM 19720663
ER
PT J
AU Dietz, WH
Story, MT
Leviton, LC
AF Dietz, William H.
Story, Mary T.
Leviton, Laura C.
TI Issues and Implications of Screening, Surveillance, and Reporting of
Children's BMI
SO PEDIATRICS
LA English
DT Article
DE overweight; adolescent overweight; body mass index; BMI; screening;
surveillance
C1 [Dietz, William H.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA.
[Story, Mary T.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
[Leviton, Laura C.] Robert Wood Johnson Fdn, Princeton, NJ 08540 USA.
RP Dietz, WH (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, 4770 Buford Hwy NE,Mailstop K-24, Atlanta, GA 30341 USA.
EM wcd4@cdc.gov
NR 4
TC 18
Z9 18
U1 0
U2 5
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD SEP
PY 2009
VL 124
BP S98
EP S101
DI 10.1542/peds.2008-3586M
PG 4
WC Pediatrics
SC Pediatrics
GA 500CS
UT WOS:000270275400011
PM 19720673
ER
PT J
AU Freedman, DS
Sherry, B
AF Freedman, David S.
Sherry, Bettylou
TI The Validity of BMI as an Indicator of Body Fatness and Risk Among
Children
SO PEDIATRICS
LA English
DT Article
DE BMI; obesity; children; body fatness; DEXA; racial differences; risk
factors; skinfolds; waist circumference
ID X-RAY ABSORPTIOMETRY; TO-HEIGHT RATIO; FOR-DISEASE-CONTROL; FAT-FREE
MASS; CHILDHOOD OBESITY; WHITE-CHILDREN; ADOLESCENT OVERWEIGHT; SKINFOLD
THICKNESSES; WAIST CIRCUMFERENCE; NUTRITIONAL-STATUS
AB PURPOSE OF REVIEW: Although the prevalence of childhood obesity, as assessed by BMI (kg/m(2)), has tripled over the last 3 decades, this index is a measure of excess weight rather than excess body fatness. In this review we focus on the relation of BMI to body fatness and health risks, particularly on the ability of BMI for age >= 95th Centers for Disease Control and Prevention [CDC] percentile to identify children who have excess body fatness. We also examine whether these associations differ according to race/ethnicity and whether skinfold and circumference measurements provide additional information on body fatness or health risks.
RESULTS: The accuracy of BMI varies according to the degree of body fatness. Among relatively fat children, BMI is a good indicator of excess adiposity, but differences in the BMIs of relatively thin children can be largely due to fat-free mass. Although the accuracy of BMI in identifying children with excess body fatness depends on the chosen cut points, we have found that a high BMI-for-age has a moderately high (70%-80%) sensitivity and positive predictive value, along with a high specificity (95%). Children with a high BMI are much more likely to have adverse risk factor levels and to become obese adults than are thinner children. Skinfold thicknesses and the waist circumference may be useful in identifying children with moderately elevated levels of BMI (85th to 94th percentiles) who truly have excess body fatness or adverse risk factor levels.
CONCLUSION: A BMI for age at >= 95th percentile of the CDC reference population is a moderately sensitive and a specific indicator of excess adiposity among children. Pediatrics 2009;124:S23-S34
C1 [Freedman, David S.; Sherry, Bettylou] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA.
RP Freedman, DS (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, 4770 Buford Hwy,Mailstop K-26, Atlanta, GA 30341 USA.
EM dfreedman@cdc.gov
NR 76
TC 153
Z9 157
U1 1
U2 24
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD SEP
PY 2009
VL 124
BP S23
EP S34
DI 10.1542/peds.2008-3586E
PG 12
WC Pediatrics
SC Pediatrics
GA 500CS
UT WOS:000270275400003
PM 19720664
ER
PT J
AU Nihiser, AJ
Lee, SM
Wechsler, H
McKenna, M
Odom, E
Reinold, C
Thompson, D
Grummer-Strawn, L
AF Nihiser, Allison J.
Lee, Sarah M.
Wechsler, Howell
McKenna, Mary
Odom, Erica
Reinold, Chris
Thompson, Diane
Grummer-Strawn, Larry
TI BMI Measurement in Schools
SO PEDIATRICS
LA English
DT Article
DE body mass index; obesity; growth and development; school health
services; child; adolescent
ID BODY-MASS INDEX; AFFECTING CHILDRENS WEIGHT; HEALTH REPORT CARDS;
MATERNAL PERCEPTIONS; PARENTS PERCEPTIONS; ELEMENTARY-SCHOOLS; CHILDHOOD
OBESITY; EXPERT COMMITTEE; US CHILDREN; OVERWEIGHT
AB BACKGROUND AND OBJECTIVE: School-based BMI measurement has attracted attention across the nation as a potential approach to address obesity among youth. However, little is known about its impact or effectiveness in changing obesity rates or related physical activity and dietary behaviors that influence obesity. This article describes current BMI-measurement programs and practices, research, and expert recommendations and provides guidance on implementing such an approach.
METHODS: An extensive search for scientific articles, position statements, and current state legislation related to BMI-measurement programs was conducted. A literature and policy review was written and presented to a panel of experts. This panel, comprising experts in public health, education, school counseling, school medical care, and parenting, reviewed and provided expertise on this article.
RESULTS: School-based BMI-measurement programs are conducted for surveillance or screening purposes. Thirteen states are implementing school-based BMI-measurement programs as required by legislation. Few studies exist that assess the utility of these programs in preventing increases in obesity or the effects these programs may have on weight-related knowledge, attitudes, and behaviors of youth and their families. Typically, expert organizations support school-based BMI surveillance; however, controversy exists over screening. BMI screening does not currently meet all of the American Academy of Pediatrics' criteria for determining whether screening for specific health conditions should be implemented in schools.
CONCLUSION: Schools initiating BMI-measurement programs should adhere to safeguards to minimize potential harms and maximize benefits, establish a safe and supportive environment for students of all body sizes, and implement science-based strategies to promote physical activity and healthy eating. Pediatrics 2009;124:S89-S97
C1 [Nihiser, Allison J.; Lee, Sarah M.; Wechsler, Howell; Odom, Erica] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA 30341 USA.
[Reinold, Chris; Thompson, Diane; Grummer-Strawn, Larry] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA.
[McKenna, Mary] Univ New Brunswick, Dept Kinesiol, Fredericton, NB, Canada.
RP Nihiser, AJ (reprint author), Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, 4770 Buford Hwy NE,Mailstop K-12, Atlanta, GA 30341 USA.
EM anihiser@cdc.gov
RI Nihiser, Allison/B-8662-2014
NR 61
TC 55
Z9 56
U1 3
U2 12
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD SEP
PY 2009
VL 124
BP S89
EP S97
DI 10.1542/peds.2008-3586L
PG 9
WC Pediatrics
SC Pediatrics
GA 500CS
UT WOS:000270275400010
PM 19720672
ER
PT J
AU Menzies, D
Benedetti, A
Paydar, A
Royce, S
Pai, M
Burman, W
Vernon, A
Lienhardt, C
AF Menzies, Dick
Benedetti, Andrea
Paydar, Anita
Royce, Sarah
Pai, Madhukar
Burman, William
Vernon, Andrew
Lienhardt, Christian
TI Standardized Treatment of Active Tuberculosis in Patients with Previous
Treatment and/or with Mono-resistance to Isoniazid: A Systematic Review
and Meta-analysis
SO PLOS MEDICINE
LA English
DT Article
ID CONTROLLED CLINICAL-TRIAL; SHORT-COURSE CHEMOTHERAPY; POSITIVE PULMONARY
TUBERCULOSIS; 6-MONTH COOPERATIVE TUBERCULOSIS; RETREATMENT REGIMEN;
SOUTH-INDIA; TREATMENT OUTCOMES; TREATMENT FAILURE; 5-MONTH REGIMENS;
COMPLETION
AB Background: A standardized regimen recommended by the World Health Organization for retreatment of active tuberculosis (TB) is widely used, but treatment outcomes are suspected to be poor. We conducted a systematic review of published evidence of treatment of patients with a history of previous treatment or documented isoniazid mono-resistance.
Methods and Findings: PubMed, EMBASE, and the Cochrane Central database for clinical trials were searched for randomized trials in previously treated patients and/or those with with mono-resistance to isoniazid, published in English, French, or Spanish between 1965 and June 2008. The first two sources were also searched for cohort studies evaluating specifically the current retreatment regimen. In studies selected for inclusion, rifampin-containing regimens were used to treat patients with bacteriologically confirmed pulmonary TB, in whom bacteriologically confirmed failure and/or relapse had been reported. Pooled cumulative incidences and 95% CIs of treatment outcomes were computed with random effects meta-analyses and negative binomial regression. No randomized trials of the currently recommended retreatment regimen were identified. Only six cohort studies were identified, in which failure rates were 18%-44% in those with isoniazid resistance. In nine trials, using very different regimens in previously treated patients with mono-resistance to isoniazid, the combined failure and relapse rates ranged from 0% to over 75%. From pooled analysis of 33 trials in 1,907 patients with mono-resistance to isoniazid, lower failure, relapse, and acquired drug resistance rates were associated with longer duration of rifampin, use of streptomycin, daily therapy initially, and treatment with a greater number of effective drugs.
Conclusions: There are few published studies to support use of the current standardized retreatment regimen. Randomized trials of treatment of persons with isoniazid mono-resistance and/or a history of previous TB treatment are urgently needed.
C1 [Menzies, Dick; Benedetti, Andrea; Paydar, Anita; Pai, Madhukar] McGill Univ, Resp & Epidemiol Clin Res Unit, Montreal Chest Inst, Montreal, PQ, Canada.
[Royce, Sarah] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Burman, William] Denver Publ Hlth, Denver, CO USA.
[Vernon, Andrew] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Lienhardt, Christian] Int Union TB & Lung Dis, Paris, France.
[Lienhardt, Christian] Inst Rech Dev, Paris, France.
RP Menzies, D (reprint author), McGill Univ, Resp & Epidemiol Clin Res Unit, Montreal Chest Inst, Montreal, PQ, Canada.
EM Dick.Menzies@mcgill.ca
FU World Health Organization; Canadian Institutes of Health Research; Fonds
de la recherche en santedu Quebec
FX Funding for this review was provided in part from the World Health
Organization. Salary support was provided by the Canadian Institutes of
Health Research for MP, Fonds de la recherche en santedu Quebec for DM
and AB. None of these agencies had any direct role in the conduct of the
study, nor the decision to submit the manuscript for publication. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 87
TC 95
Z9 97
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1549-1277
J9 PLOS MED
JI PLos Med.
PD SEP
PY 2009
VL 6
IS 9
AR e1000150
DI 10.1371/journal.pmed.1000150
PG 14
WC Medicine, General & Internal
SC General & Internal Medicine
GA 506ZH
UT WOS:000270818100013
PM 20101802
ER
PT J
AU Menzies, D
Benedetti, A
Paydar, A
Martin, I
Royce, S
Pai, M
Vernon, A
Lienhardt, C
Burman, W
AF Menzies, Dick
Benedetti, Andrea
Paydar, Anita
Martin, Ian
Royce, Sarah
Pai, Madhukar
Vernon, Andrew
Lienhardt, Christian
Burman, William
TI Effect of Duration and Intermittency of Rifampin on Tuberculosis
Treatment Outcomes: A Systematic Review and Meta-Analysis
SO PLOS MEDICINE
LA English
DT Article
ID SHORT-COURSE CHEMOTHERAPY; CONTROLLED CLINICAL-TRIAL; DIAGNOSED
PULMONARY TUBERCULOSIS; 6-MONTH COOPERATIVE TUBERCULOSIS; DOSE
COMBINATION CHEMOTHERAPY; HIV-INFECTED PATIENTS; 5-YEAR FOLLOW-UP;
SOUTH-INDIA; HONG-KONG; CONTINUATION PHASE
AB Background: Treatment regimens for active tuberculosis (TB) that are intermittent, or use rifampin during only the initial phase, offer practical advantages, but their efficacy has been questioned. We conducted a systematic review of treatment regimens for active TB, to assess the effect of duration and intermittency of rifampin use on TB treatment outcomes.
Methods and Findings: PubMed, Embase, and the Cochrane CENTRAL database for clinical trials were searched for randomized controlled trials, published in English, French, or Spanish, between 1965 and June 2008. Selected studies utilized standardized treatment with rifampin-containing regimens. Studies reported bacteriologically confirmed failure and/or relapse in previously untreated patients with bacteriologically confirmed pulmonary TB. Pooled cumulative incidences of treatment outcomes and association with risk factors were computed with stratified random effects meta-analyses. Meta-regression was performed using a negative binomial regression model. A total of 57 trials with 312 arms and 21,472 participants were included in the analysis. Regimens utilizing rifampin only for the first 1-2 mo had significantly higher rates of failure, relapse, and acquired drug resistance, as compared to regimens that used rifampin for 6 mo. This was particularly evident when there was initial drug resistance to isoniazid, streptomycin, or both. On the other hand, there was little evidence of difference in failure or relapse with daily or intermittent schedules of treatment administration, although there was insufficient published evidence of the efficacy of twice-weekly rifampin administration throughout therapy.
Conclusions: TB treatment outcomes were significantly worse with shorter duration of rifampin, or with initial drug resistance to isoniazid and/or streptomycin. Treatment outcomes were similar with all intermittent schedules evaluated, but there is insufficient evidence to support administration of treatment twice weekly throughout therapy.
C1 [Menzies, Dick; Benedetti, Andrea; Paydar, Anita; Martin, Ian; Pai, Madhukar] McGill Univ, Resp & Epidemiol Clin Res Unit, Montreal Chest Inst, Montreal, PQ, Canada.
[Menzies, Dick; Benedetti, Andrea; Paydar, Anita; Martin, Ian; Pai, Madhukar] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.
[Royce, Sarah] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Vernon, Andrew] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Lienhardt, Christian] Int Union TB & Lung Dis, Paris, France.
[Lienhardt, Christian] Inst Rech Dev, Paris, France.
[Burman, William] Denver Publ Hlth, Denver, CO USA.
RP Menzies, D (reprint author), McGill Univ, Resp & Epidemiol Clin Res Unit, Montreal Chest Inst, Montreal, PQ, Canada.
EM dick.menzies@mcgill.ca
FU Canadian Institutes of Health Research; Fonds de la Recherche en Santedu
Quebec
FX Partial support for this review came from the WHO, while the Canadian
Institutes of Health Research and the Fonds de la Recherche en Santedu
Quebec provided salary support for some authors. These funding sources
had no role in the design or conduct of the study, nor the decision to
submit the manuscript for publication.
NR 108
TC 74
Z9 75
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1549-1277
J9 PLOS MED
JI PLos Med.
PD SEP
PY 2009
VL 6
IS 9
AR e1000146
DI 10.1371/journal.pmed.1000146
PG 18
WC Medicine, General & Internal
SC General & Internal Medicine
GA 506ZH
UT WOS:000270818100010
PM 19753109
ER
PT J
AU Johnson, CY
Honein, MA
Hobbs, CA
Rasmussen, SA
AF Johnson, Candice Y.
Honein, Margaret A.
Hobbs, Charlotte A.
Rasmussen, Sonja A.
CA Natl Birth Defects Prevention Stud
TI Prenatal diagnosis of orofacial clefts, National Birth Defects
Prevention Study, 1998-2004
SO PRENATAL DIAGNOSIS
LA English
DT Article
DE cleft lip; cleft palate; prenatal diagnosis; ultrasonography
ID FACIAL CLEFTS; ULTRASOUND; PALATE; LIP; POPULATION; OBESITY;
ULTRASONOGRAPHY; IMPACT; US
AB Objective The aims of this study were to determine how frequently orofacial clefts were diagnosed prenatally and to investigate factors associated with prenatal diagnosis.
Methods We included 2298 mothers from the National Birth Defects Prevention Study, each of whom gave birth to a child with an orofacial cleft, and assessed associated factors using logistic regression.
Results The frequencies of prenatal diagnosis for cleft lip and palate, cleft lip only, and cleft palate only were 33.3%, 20.3%, and 0.3%, respectively. Among cases with cleft lip with or without cleft palate, cleft type, geographic location, maternal body mass index, household income, year of infant's birth, and presence Of multiple birth defects were significantly associated with receiving a prenatal diagnosis.
Conclusion In the majority of infants with orofacial clefts, a prenatal diagnosis was not made. Receiving a prenatal diagnosis was significantly associated with several infant and maternal characteristics. Copyright (c) 2009 John Wiley & Sons, Ltd.
C1 [Johnson, Candice Y.; Honein, Margaret A.; Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Johnson, Candice Y.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Hobbs, Charlotte A.] Univ Arkansas Med Sci, Dept Pediat, Coll Med, Little Rock, AR 72205 USA.
RP Rasmussen, SA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,Mailstop E-86, Atlanta, GA 30333 USA.
EM skr9@cdc.gov
RI Publications, NBDPS/B-7692-2013
NR 29
TC 9
Z9 9
U1 2
U2 3
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 0197-3851
J9 PRENATAL DIAG
JI Prenat. Diagn.
PD SEP
PY 2009
VL 29
IS 9
BP 833
EP 839
DI 10.1002/pd.2293
PG 7
WC Genetics & Heredity; Obstetrics & Gynecology
SC Genetics & Heredity; Obstetrics & Gynecology
GA 496BR
UT WOS:000269943500002
PM 19455588
ER
PT J
AU Nater, UM
Miller, AH
Jones, JF
Reeves, WC
AF Nater, Urs M.
Miller, Andrew H.
Jones, James F.
Reeves, William C.
TI ALTERED SALIVARY ALPHA-AMYLASE ACTIVITY UNDER BASAL AND STIMULATED
CONDITIONS IN CHRONIC FATIGUE SYNDROME
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
CT 49th Annual Meeting of the Society-for-Psychophysiological-Research
CY OCT 21-24, 2009
CL Berlin, GERMANY
SP Soc Psychophysiol Res
C1 [Nater, Urs M.] Univ Zurich, CH-8006 Zurich, Switzerland.
[Miller, Andrew H.] Emory Univ, Atlanta, GA 30322 USA.
[Jones, James F.; Reeves, William C.] Ctr Dis Control, Atlanta, GA 30333 USA.
RI Nater, Urs/J-6898-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2009
VL 46
BP S14
EP S14
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA 493NR
UT WOS:000269744700071
ER
PT J
AU Begley, EB
AF Begley, Elin B.
TI Incorporating Rapid HIV Testing into Partner Counseling and Referral
Services (vol 123, pg S126, 2008)
SO PUBLIC HEALTH REPORTS
LA English
DT Correction
C1 Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
RP Begley, EB (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD SEP-OCT
PY 2009
VL 124
IS 5
BP 624
EP 624
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 482VV
UT WOS:000268918600003
PM 19753939
ER
PT J
AU Jain, N
Singleton, JA
Montgomery, M
Skalland, B
AF Jain, Nidhi
Singleton, James A.
Montgomery, Margrethe
Skalland, Benjamin
TI Determining Accurate Vaccination Coverage Rates for Adolescents: The
National Immunization Survey-Teen 2006
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID AGED 13-17 YEARS; UNITED-STATES; DELIVERY; REGISTRY
AB Since 1994, the Centers for Disease Control and Prevention has funded the National Immunization Survey (NIS), a large telephone survey used to estimate vaccination coverage of U.S. children aged 19-35 months. The NIS is a two-phase survey that obtains vaccination receipt information from a random-digit-dialed survey, designed to identify households with eligible children, followed by a provider record check, which obtains provider-reported vaccination histories for eligible children. In 2006, the survey was expanded for the first time to include a national sample of adolescents aged 13-17 years, called the NIS-Teen. This article summarizes the methodology used in the NIS-Teen. In 2008, the NIS-Teen was expanded to collect state-specific and national-level data to determine vaccination coverage estimates. This survey provides valuable information to guide immunization programs for adolescents.
C1 [Jain, Nidhi; Singleton, James A.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Alameda, CA USA.
[Montgomery, Margrethe; Skalland, Benjamin] Univ Chicago, Natl Opin Res Ctr, Chicago, IL 60637 USA.
RP Jain, N (reprint author), US Coast Guard, Med Clin, Alameda, CA 94501 USA.
EM nidhijain415@gmail.com
NR 21
TC 40
Z9 40
U1 0
U2 1
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD SEP-OCT
PY 2009
VL 124
IS 5
BP 642
EP 651
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 482VV
UT WOS:000268918600006
PM 19753942
ER
PT J
AU Duke, CW
Correa, A
Romitti, PA
Martin, J
Kirby, RS
AF Duke, C. Wes
Correa, Adolfo
Romitti, Paul A.
Martin, Joyce
Kirby, Russell S.
TI Challenges and Priorities for Surveillance of Stillbirths: A Report on
Two Workshops
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID FETAL-DEATH CERTIFICATES; BIRTH-DEFECTS SURVEILLANCE; MATERNAL OBESITY;
UNITED-STATES; RISK-FACTORS; PREGNANCY; CLASSIFICATION; PREVENTION;
STANDARD; VALIDITY
AB Stillbirths, those with and without birth defects, are an important public health topic. The National Center on Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention conducted two workshops during April and July 2005. Both workshops explored the challenges of conducting surveillance of stillbirths. Workshop participants considered an approach that added the surveillance of stillbirths, those with and without birth defects, as part of existing population-based birth defects surveillance programs in Iowa and Atlanta. The workshops addressed three key aspects for expanding birth defects programs to conduct active, population-based surveillance on stillbirths: (1) case identification and ascertainment, (2) data collection, and (3) data use and project evaluation. Participants included experts in pediatrics, obstetrics, epidemiology, maternal-fetal medicine, perinatology and pediatric pathology, midwifery, as well as practicing clinicians and pathologists. Expanding existing birth defects surveillance programs to include information of stillbirths could potentially enhance the data available on fetal death reports and also could benefit such programs by improving the ascertainment of birth defects.
C1 [Duke, C. Wes; Correa, Adolfo] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Romitti, Paul A.] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA USA.
[Martin, Joyce] Ctr Dis Control & Prevent, Div Vital Stat, Natl Ctr Hlth Stat, Hyattsville, MD USA.
[Kirby, Russell S.] Univ S Florida, Coll Publ Hlth, Dept Community & Family Hlth, Tampa, FL USA.
RP Duke, CW (reprint author), Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,MS E-86, Atlanta, GA 30333 USA.
EM cduke@cdc.gov
NR 48
TC 4
Z9 4
U1 0
U2 1
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD SEP-OCT
PY 2009
VL 124
IS 5
BP 652
EP 659
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 482VV
UT WOS:000268918600007
PM 19753943
ER
PT J
AU Coyle, KK
Potter, S
Schneider, D
May, G
Robin, LE
Seymour, J
Debrot, K
AF Coyle, Karin K.
Potter, Susan
Schneider, Doris
May, Gary
Robin, Leah E.
Seymour, Jennifer
Debrot, Karen
TI Distributing Free Fresh Fruit and Vegetables at School: Results of a
Pilot Outcome Evaluation
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID CHILDRENS FOOD PREFERENCES; EATING PATTERNS; YOUNG-CHILDREN; PROJECT
EAT; GIMME 5; ADOLESCENTS; CONSUMPTION; HEALTH; INTERVENTION; STUDENTS
AB Objectives. Consumption of fruit and vegetables among children is generally below recommended levels. This evaluation addressed two questions: (1) To what extent did children's attitudes toward, familiarity with, and preferences for fruit and vegetables change during the school year? and (2) To what extent did children's consumption of fruit and vegetables change during the school year?
Methods. During the 2004-2005 school year, the Mississippi Department of Education, Child Nutrition Programs initiated a pilot program to distribute free fruit and vegetables to students (kindergarten through 12th grade) during the school day. Data were collected in 2004-2005 within a one-group pretest/posttest design using a self-report questionnaire (n=725) and 24-hour dietary recalls (n=207) with a sample of students from five schools in Mississippi. Data were analyzed in 2006-2007.
Results. Results showed greater familiarity with fruit and vegetables at all grade levels (p<0.05) and increased preferences for fruit among eighth- and 10th-grade students (p<0.01). Eighth-grade students also reported more positive attitudes toward eating fruit and vegetables (p<0.01), increased perceived self-efficacy to eat more fruit (p<0.01), and increased willingness to try new fruit. Finally, results showed increased consumption of fruit, but not vegetables, among eighth- and 10th-grade students (p<0.001).
Conclusions. Distributing free fruit and vegetables at school may be a viable component of a more comprehensive approach for improving students' nutrition attitudes and behaviors. More program emphasis is needed on ways to promote vegetable consumption.
C1 [Coyle, Karin K.; Potter, Susan] ETR Associates, Scotts Valley, CA 95066 USA.
[Schneider, Doris; May, Gary] Mississippi Dept Educ, Off Child Nutr Programs, Jackson, MS USA.
[Robin, Leah E.; Debrot, Karen] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA USA.
[Seymour, Jennifer] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA.
RP Coyle, KK (reprint author), ETR Associates, 4 Carbonero Way, Scotts Valley, CA 95066 USA.
EM karinc@etr.org
FU Division of Adolescent and School Health, National Center for Chronic
Disease Prevention and Health Promotion, Centers for Disease Control and
Prevention (CDC) [200-2002-00800]
FX The Mississippi Fruit and Vegetable Program pilot evaluation was
supported by funding from the Division of Adolescent and School Health,
National Center for Chronic Disease Prevention and Health Promotion,
Centers for Disease Control and Prevention (CDC) (Contract #
200-2002-00800).
NR 35
TC 14
Z9 15
U1 3
U2 8
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD SEP-OCT
PY 2009
VL 124
IS 5
BP 660
EP 669
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 482VV
UT WOS:000268918600008
PM 19753944
ER
PT J
AU MacDorman, MF
Mathews, TJ
AF MacDorman, Marian F.
Mathews, T. J.
TI The Challenge of Infant Mortality: Have We Reached a Plateau?
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID US SINGLETON BIRTHS; UNITED-STATES; PRETERM BIRTH; GESTATIONAL-AGE;
HEALTH INDICATORS; PERINATAL HEALTH; VITAL-STATISTICS; WEIGHT; RATES;
EUROPE
AB Objectives. Infant mortality is a major indicator of the health of a nation. We analyzed recent patterns and trends in U.S. infant mortality, with an emphasis on two of the greatest challenges: (1) persistent racial and ethnic disparities and (2) the impact of preterm and low birthweight delivery.
Methods. Data from the national linked birth/infant death datasets were used to compute infant mortality rates per 100,000 live births by cause of death (COD), and per 1,000 live births for all other variables. Infant mortality rates and other measures of infant health were analyzed and compared. Leading and preterm-related CODs, and international comparisons of infant mortality rates were also examined.
Results. Despite the rapid decline in infant mortality during the 20th century, the U.S. infant mortality rate did not decline from 2000 to 2005, and declined only marginally in 2006. Racial and ethnic disparities in infant mortality have persisted and increased, as have the percentages of preterm and low birthweight deliveries. After decades of improvement, the infant mortality rate for very low birthweight infants remained unchanged from 2000 to 2005. Infant mortality rates from congenital malformations and sudden infant death syndrome declined; however, rates for preterm-related CODs increased. The U.S. international ranking in infant mortality fell from 12th place in 1960 to 30th place in 2005.
Conclusions. Infant mortality is a complex and multifactorial problem that has proved resistant to intervention efforts. Continued increases in preterm and low birthweight delivery present major challenges to further improvement in the infant mortality rate.
C1 [MacDorman, Marian F.; Mathews, T. J.] Ctr Dis Control & Prevent, Reprod Stat Branch, Div Vital Stat, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
RP MacDorman, MF (reprint author), Ctr Dis Control & Prevent, Reprod Stat Branch, Div Vital Stat, Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 7318, Hyattsville, MD 20782 USA.
EM mfm1@cdc.gov
NR 44
TC 17
Z9 19
U1 0
U2 3
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD SEP-OCT
PY 2009
VL 124
IS 5
BP 670
EP 681
PG 12
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 482VV
UT WOS:000268918600009
PM 19753945
ER
PT J
AU Bertrand, J
AF Bertrand, Jacquelyn
CA Interventions Children Fetal Alcoh
TI Interventions for children with fetal alcohol spectrum disorders
(FASDs): Overview of findings for five innovative research projects
SO RESEARCH IN DEVELOPMENTAL DISABILITIES
LA English
DT Article
ID BEHAVIOR PROBLEM CHILDREN; ACADEMIC-ACHIEVEMENT; INTERACTION THERAPY;
EXPOSED CHILDREN; SATISFACTION; PREVALENCE; PARENTS; ADULTS; AGE
AB It is well established that prenatal exposure to alcohol causes damage to the developing fetus, resulting in a spectrum of disorders known as fetal alcohol spectrum disorders (FASDs). Although our understanding of the deficits and disturbances associated with FASDs is far from complete, there are consistent findings indicating these are serious, lifelong disabilities-especially when these disabilities result from central nervous system damage. Until recently, information and strategies for interventions specific to individuals with FASDs have been gleaned from interventions used with people with other disabilities and from the practical wisdom gained by parents and clinicians through trial and error or shared through informal networks. Although informative to a limited degree, such interventions have been implemented without being evaluated systematically or scientifically. The purpose of this article is to provide a brief overview of a general intervention framework developed for individuals with FASDs and the methods and general findings of five specific intervention research studies conducted within this framework. The studies evaluated five different interventions in five diverse locations in the United States, with different segments of the FASD population. Nonetheless, all participants showed improvement in the target behaviors or skills, with four studies achieving statistical significance in treatment Outcomes. important lessons emerged from these five interventions that may explain Success: including parent education or training, teaching children specific skills they would usually learn by observation or abstraction, and integration into existing systems of treatment. A major implication of these research studies for families dealing with FASDs is that there are now interventions available that can address their children's needs and that can be presented as scientifically validated and efficacious to intervention agents Such as schools, social services, and mental health providers. In the field of FASD research and clinical service, a common theme reported by families has been that clinicians and professionals have been reluctant to diagnose their children because there were no known effective treatments. Results of these five Studies dispel that concern by demonstrating several interventions that have been shown to improve the lives of individuals with FASDs and their families. Published by Elsevier Ltd.
C1 [Bertrand, Jacquelyn] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA.
RP Bertrand, J (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS E-86, Atlanta, GA 30329 USA.
EM jbertrand@cdc.gov
OI Chaffin, Mark/0000-0002-3620-6583
NR 82
TC 55
Z9 56
U1 2
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0891-4222
J9 RES DEV DISABIL
JI Res. Dev. Disabil.
PD SEP-OCT
PY 2009
VL 30
IS 5
BP 986
EP 1006
DI 10.1016/j.ridd.2009.02.003
PG 21
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 443CU
UT WOS:000265888600020
PM 19327965
ER
PT J
AU Levin, EM
Koopman, JS
Aral, SO
Holmes, KK
Foxman, B
AF Levin, Elizabeth M.
Koopman, James S.
Aral, Sevgi O.
Holmes, King K.
Foxman, Betsy
TI Characteristics of Men Who Have Sex With Men and Women and Women Who
Have Sex With Women and Men: Results From the 2003 Seattle Sex Survey
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
ID RISK; INFECTIONS
C1 [Levin, Elizabeth M.; Koopman, James S.; Foxman, Betsy] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA.
[Aral, Sevgi O.] Ctr Dis Control & Prevent, Div STD, Atlanta, GA USA.
[Holmes, King K.] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA.
[Holmes, King K.] Univ Washington, Ctr AIDS & STD, Seattle, WA 98195 USA.
RP Foxman, B (reprint author), Univ Michigan, Dept Epidemiol, 109 Observ St, Ann Arbor, MI 48109 USA.
EM bfoxman@umich.edu
OI Foxman, Betsy/0000-0001-6682-238X
FU Department of Public Health-Seattle King County, the Center for
Molecular and Clinical Epidemiology of Infectious Diseases (MAC-EPID);
University of Michigan School of Public Health, the University of
Washington Center
FX This work was funded by The Department of Public Health-Seattle King
County, the Center for Molecular and Clinical Epidemiology of Infectious
Diseases (MAC-EPID) at the University of Michigan School of Public
Health, the University of Washington Center for AIDS and STD, and the
James S. McDonnell Foundation.
NR 13
TC 9
Z9 9
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-5717
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD SEP
PY 2009
VL 36
IS 9
BP 541
EP 546
DI 10.1097/OLQ.0b013e3181a819db
PG 6
WC Infectious Diseases
SC Infectious Diseases
GA 488TX
UT WOS:000269374100003
PM 19543142
ER
PT J
AU Akksilp, S
Wattanaamornkiat, W
Kittikraisak, W
Nateniyom, S
Rienthong, S
Sirinak, C
Ngamlert, K
Mankatittham, W
Sattayawuthipong, W
Sumnapun, S
Yamada, N
Monkongdee, P
Anuwatnonthakate, A
Burapat, C
Wells, CD
Tappero, JW
Varma, JK
AF Akksilp, Somsak
Wattanaamornkiat, Wanpen
Kittikraisak, Wanitchaya
Nateniyom, Sriprapa
Rienthong, Somsak
Sirinak, Chawin
Ngamlert, Keerataya
Mankatittham, Wiroj
Sattayawuthipong, Wanchai
Sumnapun, Surin
Yamada, Norio
Monkongdee, Patama
Anuwatnonthakate, Amornrat
Burapat, Channawong
Wells, Charles D.
Tappero, Jordan W.
Varma, Jay K.
TI MULTIDRUG-RESISTANT TB AND HIV IN THAILAND: OVERLAPPING, BUT NOT
INDEPENDENTLY ASSOCIATED, RISK FACTORS
SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH
LA English
DT Article
ID HEALTH-CARE; DRUG-USERS; TUBERCULOSIS; BANGKOK; PERFORMANCE; MANAGEMENT;
INFECTION; IMPACT; PRISON; SIDE
AB The HIV and multi-drug resistant tuberculosis (MDR-TB) epidemics are closely linked. In Thailand as part of a sentinel surveillance system, we collected data prospectively about pulmonary TB cases treated in public clinics. A subset of HIV-infected TB patients identified through this system had additional data collected for a research study. We conducted multivariate analysis to identify factors associated with MDR-TB. Of 10,428 TB patients, 2,376 (23%) were HIV-infected; 145 (1%) had MDR-TB. Of the MDR-TB cases, 52 (37%) were HIV-infected. Independent risk factors for MDR-TB included age 18-29 years old, male sex, and previous TB treatment, but not HIV infection. Among new patients, having an injection drug use history was a risk factor for MDR-TB. Of 539 HIV-infected TB patients in the research study, MDR-TB was diagnosed in 1.9 (4%); the only significant risk factors were previous TB treatment and previous hepatitis. In Thailand, HIV is common among MDR-TB patients, but is not an independent risk factor for MDR-TB. Populations at high risk for HIV-young adults, men, injection drug users - should be prioritized for drug susceptibility testing.
C1 [Akksilp, Somsak; Wattanaamornkiat, Wanpen] Off Dis Prevent & Control 7, Ubon Ratchathani, Thailand.
[Kittikraisak, Wanitchaya; Monkongdee, Patama; Anuwatnonthakate, Amornrat] US CDC Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand.
[Sirinak, Chawin; Ngamlert, Keerataya] Bangkok Metropolitan Adm, Dept Hlth, Bangkok, Thailand.
[Mankatittham, Wiroj] Bamrasnaradura Infect Dis Inst, Nonthaburi, Thailand.
[Sattayawuthipong, Wanchai] Phuket Prov Hlth Off, Phuket, Thailand.
[Sumnapun, Surin] Chiang Rai Prov Hlth Off, Chiang Rai, Thailand.
[Yamada, Norio; Tappero, Jordan W.; Varma, Jay K.] Res Inst TB, Tokyo, Japan.
[Wells, Charles D.; Tappero, Jordan W.; Varma, Jay K.] US Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Varma, JK (reprint author), CDC, US Embassy Beijing, 55 An Jia Lou Rd, Beijing 100600, Peoples R China.
EM jvarma@cdc.gov
FU US Agency for International Development
FX We thank the US Agency for International Development for funding this
study. The funding agency had no role in the study design, conduct, data
analysis, or manuscript preparation. None of the authors have a
commercial or other financial interest associated with the information
presented in this manuscript.
NR 30
TC 5
Z9 5
U1 0
U2 2
PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION
PI BANGKOK
PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND
SN 0125-1562
J9 SE ASIAN J TROP MED
JI Southeast Asian J. Trop. Med. Public Health
PD SEP
PY 2009
VL 40
IS 5
BP 1000
EP 1014
PG 15
WC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
SC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
GA 503FW
UT WOS:000270519800017
PM 19842383
ER
PT J
AU Ishida, K
Stupp, P
Melian, M
AF Ishida, Kanako
Stupp, Paul
Melian, Mercedes
TI Fertility Decline in Paraguay
SO STUDIES IN FAMILY PLANNING
LA English
DT Article
ID PROXIMATE DETERMINANTS; FRAMEWORK; RATES
AB Recent reproductive health surveys show that the fertility rate in Paraguay decreased precipitously from 4.3 lifetime births per woman in 1995-98 to 2.9 births in 2001-04. In this study, we establish data consistency between the 1998 and 2004 surveys by comparing a series of cohort-specific period rates and use the Bongaarts framework of proximate determinants of fertility to demonstrate that an increase in the contraceptive prevalence rate (CPR) between 1998 and 2004 fully accounts for the fertility decline. Decomposition of rates shows that changes in group-specific CPRs explain a greater proportion of the change in the overall CPR than do changes in population composition by educational attainment, urban residence, region, and language spoken at home. Finally, we show that younger cohorts of women in 2004 reported ideal completed fertility desires of less than 2.9 births, suggesting that the fertility rate is likely to continue to decrease. (STUDIES IN FAMILY PLANNING 2009; 40[3]: 227-234)
C1 [Stupp, Paul] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA.
[Melian, Mercedes] Ctr Paraguayo Estudios Poblac, Dept Invest & Evaluac, Asuncion, Paraguay.
EM kishida@cdc.gov
NR 18
TC 3
Z9 3
U1 1
U2 2
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0039-3665
J9 STUD FAMILY PLANN
JI Stud. Fam. Plan.
PD SEP
PY 2009
VL 40
IS 3
BP 227
EP 234
PG 8
WC Demography; Public, Environmental & Occupational Health
SC Demography; Public, Environmental & Occupational Health
GA 495JN
UT WOS:000269887400005
PM 19852412
ER
PT J
AU Gregory, CO
Serdula, MK
Sullivan, KM
AF Gregory, Cria O.
Serdula, Mary K.
Sullivan, Kevin M.
TI Use of Supplements with and without Iodine in Women of Childbearing Age
in the United States
SO THYROID
LA English
DT Letter
ID NATIONAL-HEALTH; NUTRITION
C1 [Gregory, Cria O.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30341 USA.
[Gregory, Cria O.; Serdula, Mary K.; Sullivan, Kevin M.] Ctr Dis Control & Prevent, Nutr Branch, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA.
[Sullivan, Kevin M.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
RP Gregory, CO (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, 4770 Buford Hwy NE,MS K-25, Atlanta, GA 30341 USA.
EM cgregory@cdc.gov
NR 6
TC 25
Z9 25
U1 1
U2 3
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1050-7256
J9 THYROID
JI Thyroid
PD SEP
PY 2009
VL 19
IS 9
BP 1019
EP 1020
DI 10.1089/thy.2009.0166
PG 2
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 491KP
UT WOS:000269577900018
PM 19678748
ER
PT J
AU Ramos, MM
Tomashek, KM
Arguello, DF
Luxemburger, C
Quinones, L
Lang, J
Munoz-Jordan, JL
AF Ramos, Mary M.
Tomashek, Kay M.
Arguello, D. Fermin
Luxemburger, Christine
Quinones, Luz
Lang, Jean
Munoz-Jordan, Jorge L.
TI Early clinical features of dengue infection in Puerto Rico
SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
DE Dengue; Diagnosis; Clinical signs; Prevention; Children; Puerto Rico
ID CHILDREN; EPIDEMIC; ADULTS; FEVER; SURVEILLANCE; ENCEPHALITIS;
INDICATORS; SEROTYPE
AB Early diagnosis of dengue is challenging because the initial symptoms are often non-specific, viraemia may be below detectable levels and serological tests confirm dengue late in the course of illness. Identifying dengue early in the clinical course could be useful in reducing dengue virus transmission in a community. This study analyzed data from 145 laboratory-positive and 293 laboratory-negative dengue cases in Puerto Rico to define the early clinical features of dengue infection in children and adults and to identify the clinical features that predict a laboratory-positive dengue infection. Among children, rash and age were independently associated with laboratory-positive dengue infection. Rash in the absence of cough had a positive predictive value of 100% and a negative predictive value of 82.4% as a paediatric dengue screen. Among adults, eye pain, diarrhoea and absence of upper respiratory symptoms were independently associated with laboratory-positive dengue infection. No useful early predictors of dengue infection among adults were found. Using clinical features may promote earlier identification of a subset of paediatric dengue patients in Puerto Rico. Laboratory confirmation is still necessary for the accurate diagnosis of dengue infection. (C) 2008 Royal Society of Tropical Medicine and Hygiene. All rights reserved.
C1 [Ramos, Mary M.; Tomashek, Kay M.; Arguello, D. Fermin; Quinones, Luz; Munoz-Jordan, Jorge L.] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Infect Dis, San Juan, PR 00920 USA.
[Ramos, Mary M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Atlanta, GA 30333 USA.
[Luxemburger, Christine] Sanofi Pasteur, F-69367 Lyon, France.
[Lang, Jean] Sanofi Pasteur, F-69280 Marcy Letoile, France.
RP Ramos, MM (reprint author), Univ New Mexico, Dept Pediat, 300 San Mateo Blvd NE,Suite 902, Albuquerque, NM 87108 USA.
EM mramos@salud.unm.edu
FU Sanofi Pasteur
FX This work was supported by funding from Sanofi Pasteur.
NR 26
TC 18
Z9 18
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0035-9203
J9 T ROY SOC TROP MED H
JI Trans. Roy. Soc. Trop. Med. Hyg.
PD SEP
PY 2009
VL 103
IS 9
BP 878
EP 884
DI 10.1016/j.trstmh.2008.11.009
PG 7
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 506RT
UT WOS:000270794100005
PM 19111871
ER
PT J
AU Fischer, GE
Thompson, N
Chaves, SS
Bower, W
Goldstein, S
Armstrong, G
Williams, I
Bialek, S
AF Fischer, Gayle E.
Thompson, Nicola
Chaves, Sandra S.
Bower, William
Goldstein, Susan
Armstrong, Gregory
Williams, Ian
Bialek, Stephanie
TI The epidemiology of hepatitis A virus infections in four Pacific Island
nations, 1995-2008
SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
DE Hepatitis A virus; Pacific Islands; American Samoa; Federated States of
Micronesia; Republic of Palau; Republic of the Marshall Islands
ID COST-EFFECTIVENESS; VACCINATION; ANTIBODY; ADULTS
AB Historically, hepatitis A virus (HAV) has been highly prevalent in developing countries, with most infections occurring during childhood, when they are likely to be asymptomatic. Shifts in the acquisition of infection from childhood to adulthood, when clinical hepatitis is more likely, may leave populations vulnerable to large outbreaks. We conducted cross-sectional serosurveys from 1995 to 2008 in four Pacific Island nations to determine the proportion of people previously infected with HAV by measuring antibodies to HAV (anti-HAV). In American Samoa, 0.0% of 4- to 6-year-oids (95% CI 0.0-3.7) were anti-HAV positive. In Chuuk, FSM, 8.6% of 2- to 6-year-olds (95% CI 5.7-11.5) were anti-HAV positive compared with 98.3% of individuals >= 16 years old (95% CI 96.6-100). In Pohnpei, FSM, 0.8% of 2- to 9-year-olds (95% CI 0.0-1.6) were anti-HAV positive compared with 95.1% of >= 16 year-olds (95% CI 92.2-98.0). In RMI, 85.7% (95% CI 81.9-89.5) of 4- to 9-year-olds were anti-HAV positive. In Palau, 0.7% of 7- to 8-year-olds were anti-HAV positive (95% CI 0.0-1.8). The tow HAV seroprevalence among children in American Samoa, FSM and Palau may indicate a vulnerability to hepatitis A morbidity among these populations. These data wilt be useful for evaluating the need for hepatitis A surveillance and vaccination programs. Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene.
C1 [Fischer, Gayle E.; Thompson, Nicola; Chaves, Sandra S.; Bower, William; Goldstein, Susan; Armstrong, Gregory; Williams, Ian; Bialek, Stephanie] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA.
RP Fischer, GE (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, 1600 Clifton Rd, Atlanta, GA 30333 USA.
EM gefischer@cdc.gov
NR 17
TC 2
Z9 3
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0035-9203
J9 T ROY SOC TROP MED H
JI Trans. Roy. Soc. Trop. Med. Hyg.
PD SEP
PY 2009
VL 103
IS 9
BP 906
EP 910
DI 10.1016/j.trstmh.2009.05.001
PG 5
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 506RT
UT WOS:000270794100009
PM 19520409
ER
PT J
AU Busch, MP
Winkelman, V
Williams, JD
Prince, HE
Yeh, C
Custer, B
Petersen, LR
AF Busch, M. P.
Winkelman, V.
Williams, J. Dunn
Prince, H. E.
Yeh, C.
Custer, B.
Petersen, L. R.
TI Correlation between Yield of WNV NAT Screening of North Dakota Donors
Over 6 Epidemic Seasons with WNV Seroprevalence at the End of 2008
SO TRANSFUSION
LA English
DT Meeting Abstract
CT 62nd Annual Meeting of the American-Association-of-Blood-Banks
CY OCT 24-27, 2009
CL New Orleans, LA
SP Amer Assoc Blood Banks
C1 [Busch, M. P.; Custer, B.] Blood Syst Res Inst, San Francisco, CA USA.
[Busch, M. P.; Custer, B.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Winkelman, V.; Williams, J. Dunn] Blood Syst Lab, Tempe, AZ USA.
[Prince, H. E.; Yeh, C.] Focus Diagnost, Cypress, CA USA.
[Petersen, L. R.] Ctr Dis Control & Prevent, DVBID, Ft Collins, CO USA.
EM mbusch@bloodsystems.org
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2009
VL 49
BP 29A
EP 29A
PG 1
WC Hematology
SC Hematology
GA 490XU
UT WOS:000269542200075
ER
PT J
AU Carrick, JM
Knight, J
Lontoc-Bugay, C
Motta, C
Wellbaum, JB
Fleischer, C
Munor, JL
Stramer, SL
Linnen, JM
AF Carrick, J. M.
Knight, J.
Lontoc-Bugay, C.
Motta, C.
Wellbaum, J. B.
Fleischer, C.
Munor, J. L.
Stramer, S. L.
Linnen, J. M.
TI Highly Sensitive and Equivalent Detection of Dengue Virus Serotypes 1,
2, 3, and 4 with an Enhanced Transcription-Mediated Amplification Assay
SO TRANSFUSION
LA English
DT Meeting Abstract
CT 62nd Annual Meeting of the American-Association-of-Blood-Banks
CY OCT 24-27, 2009
CL New Orleans, LA
SP Amer Assoc Blood Banks
C1 [Carrick, J. M.; Knight, J.; Lontoc-Bugay, C.; Motta, C.; Wellbaum, J. B.; Fleischer, C.; Linnen, J. M.] Gen Probe Inc, San Diego, CA USA.
[Stramer, S. L.] Amer Red Cross, Gaithersburg, MD USA.
[Munor, J. L.] Ctr Dis Control & Prevent, San Juan, PR USA.
EM jamesca@gen-probe.com
NR 0
TC 1
Z9 1
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2009
VL 49
BP 29A
EP 29A
PG 1
WC Hematology
SC Hematology
GA 490XU
UT WOS:000269542200074
ER
PT J
AU Norris, PJ
Glynn, SA
Todd, DS
Likos, AM
Heitman, JW
Collins, CS
Linnen, JM
Busch, MP
AF Norris, P. J.
Glynn, S. A.
Todd, D. S.
Likos, A. M.
Heitman, J. W.
Collins, C. S.
Linnen, J. M.
Busch, M. P.
TI Assessment for Influenza A Virus in Blood Donors
SO TRANSFUSION
LA English
DT Meeting Abstract
CT 62nd Annual Meeting of the American-Association-of-Blood-Banks
CY OCT 24-27, 2009
CL New Orleans, LA
SP Amer Assoc Blood Banks
C1 [Norris, P. J.; Heitman, J. W.; Busch, M. P.] Blood Syst Res Inst, San Francisco, CA USA.
[Norris, P. J.; Busch, M. P.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Glynn, S. A.] NHLBI, Bethesda, MD 20892 USA.
[Todd, D. S.] Westat Corp, Rockville, MD USA.
[Likos, A. M.] Ctr Dis Control & Prevent, DVRD, NCID, Atlanta, GA USA.
[Collins, C. S.; Linnen, J. M.] Gen Probe Inc, San Diego, CA USA.
EM pnorris@bloodsystems.org
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2009
VL 49
BP 43A
EP 43A
PG 1
WC Hematology
SC Hematology
GA 490XU
UT WOS:000269542200108
ER
PT J
AU Dorsey, K
Trouen-Trend, J
Zou, S
Schonberger, LB
Dodd, RY
AF Dorsey, K.
Trouen-Trend, J.
Zou, S.
Schonberger, L. B.
Dodd, R. Y.
TI Record Linkage Uses in Identifying Blood Donors to Evaluate Donor Health
Outcomes
SO TRANSFUSION
LA English
DT Meeting Abstract
CT 62nd Annual Meeting of the American-Association-of-Blood-Banks
CY OCT 24-27, 2009
CL New Orleans, LA
SP Amer Assoc Blood Banks
C1 [Dorsey, K.; Trouen-Trend, J.; Zou, S.; Dodd, R. Y.] Amer Red Cross, Jerome H Holland Lab, Transmissible Dis Dept, Rockville, MD USA.
[Schonberger, L. B.] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Div Viral & Rickettsial Dis, Atlanta, GA USA.
EM dorseyke@usa.redcross.org
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2009
VL 49
BP 221A
EP 221A
PG 1
WC Hematology
SC Hematology
GA 490XU
UT WOS:000269542200577
ER
PT J
AU Harris, JR
Cavallaro, EC
de Nobrega, AA
Barrado, JCBD
Bopp, C
Parsons, MB
Djalo, D
Fonseca, FGD
Ba, U
Semedo, A
Sobel, J
Mintz, ED
AF Harris, Julie R.
Cavallaro, Elizabeth C.
de Nobrega, Aglaer A.
Barrado, Jean C. B. dos S.
Bopp, Cheryl
Parsons, Michele B.
Djalo, Djulde
Fonseca, Fatima G. da S.
Ba, Umaro
Semedo, Agostinho
Sobel, Jeremy
Mintz, Eric D.
TI Field evaluation of Crystal VC (R) Rapid Dipstick test for cholera
during a cholera outbreak in Guinea-Bissau
SO TROPICAL MEDICINE & INTERNATIONAL HEALTH
LA English
DT Article
DE cholera; vibrio; rapid test; dipstick; Guinea-Bissau; diarrhoea
ID POLYMERASE-CHAIN-REACTION; VIBRIO-CHOLERAE; DIAGNOSIS; O139
AB OBJECTIVES To evaluate performance characteristics and ease of use of the new commercially available Crystal VC (R) Rapid Dipstick (VC) test (Span Diagnostics, India) for Vibrio cholerae O1 and O139.
METHODS Whole stool was collected from patients presenting to a hospital cholera ward during a 2008 epidemic in Guinea-Bissau. The VC test on stool samples was conducted on-site; samples were subsequently stored in Cary-Blair transport media and sent to the Centers for Disease Control and Prevention for diagnostic testing by culture and polymerase chain reaction (PCR). In addition, four local laboratory technicians who were unfamiliar with the test were provided with stool samples, the VC test kit, and simple written instructions and asked to perform the test and interpret results.
RESULTS A total of 101 stool specimens were collected and tested. Compared with PCR, the test was 97% sensitive and 71-76% specific. Laboratory technicians in Bissau performed the test and interpreted results correctly using only simple written instructions.
CONCLUSIONS The VC test may be useful for cholera diagnosis in outbreak situations where laboratory capacity is limited.
C1 [Harris, Julie R.; Cavallaro, Elizabeth C.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30329 USA.
[de Nobrega, Aglaer A.; Barrado, Jean C. B. dos S.] Minist Saude, Dept Epidemiol Surveillance, Brasilia, DF, Brazil.
[Barrado, Jean C. B. dos S.] Minist Saude, Field Epidemiol Training Program, Brasilia, DF, Brazil.
[Djalo, Djulde; Fonseca, Fatima G. da S.; Ba, Umaro; Semedo, Agostinho] Simao Mendes Natl Hosp, Bissau, Guinea Bissau.
RP Harris, JR (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30329 USA.
EM ggt5@cdc.gov
NR 19
TC 26
Z9 26
U1 1
U2 2
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1360-2276
J9 TROP MED INT HEALTH
JI Trop. Med. Int. Health
PD SEP
PY 2009
VL 14
IS 9
BP 1117
EP 1121
DI 10.1111/j.1365-3156.2009.02335.x
PG 5
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 487HY
UT WOS:000269263800020
PM 19624473
ER
PT J
AU Noonan, RK
Charles, D
AF Noonan, Rita K.
Charles, Dyanna
TI Developing Teen Dating Violence Prevention Strategies Formative Research
With Middle School Youth
SO VIOLENCE AGAINST WOMEN
LA English
DT Article
DE focus groups; formative research; prevention programming; teen dating
violence
ID INTIMATE PARTNER VIOLENCE; HEALTH CONSEQUENCES; RISK; AGGRESSION;
ADOLESCENTS; MEN; VICTIMIZATION; PREDICTORS; ATTITUDES
AB Intimate partner violence (IPV) peaks in youth and young adulthood and is associated with multiple adolescent risk behaviors and negative health outcomes. Targeting youth with prevention messages before they start dating may avert teen dating violence and subsequent adult IPV. This article discusses findings from focus groups with middle school youth to determine behaviors and beliefs regarding dating violence. To develop effective prevention messages, participants were asked questions about characteristics of middle school dating relationships, healthy relationships, relationship norms, unhealthy relationships, emotional abuse, physical abuse, sexual abuse, intervening in violent situations, and trusted sources for information about dating violence. The recommendations for prevention efforts include an emphasis on skill building, tailoring efforts for particular subgroups, and identifying innovative ways of reaching youth.
C1 [Noonan, Rita K.] Ctr Dis Control & Prevent, Home & Recreat Team, Div Unintent Injury, Atlanta, GA 30333 USA.
[Charles, Dyanna] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA 30333 USA.
RP Noonan, RK (reprint author), Ctr Dis Control & Prevent, Home & Recreat Team, Div Unintent Injury, Atlanta, GA 30333 USA.
NR 39
TC 35
Z9 36
U1 2
U2 16
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1077-8012
J9 VIOLENCE AGAINST WOM
JI Violence Against Women
PD SEP
PY 2009
VL 15
IS 9
BP 1087
EP 1105
DI 10.1177/1077801209340761
PG 19
WC Women's Studies
SC Women's Studies
GA 482UC
UT WOS:000268913300009
PM 19675364
ER
PT J
AU Martin, MA
Frisco, ML
May, AL
AF Martin, Molly A.
Frisco, Michelle L.
May, Ashleigh L.
TI GENDER AND RACE/ETHNIC DIFFERENCES IN INACCURATE WEIGHT PERCEPTIONS
AMONG US ADOLESCENTS
SO WOMENS HEALTH ISSUES
LA English
DT Article
ID BODY-MASS INDEX; UNITED-STATES; OVERWEIGHT; HEALTH; ASSOCIATION;
PREVALENCE; BEHAVIORS; STUDENTS; OBESITY; IMAGE
AB Purpose. Inaccurate weight perceptions may lead to unhealthy weight control practices among normal weight adolescents and to a greater risk of adult obesity and related morbidities for overweight adolescents. To examine which U.S. adolescents are at risk of these outcomes, we examine gender and racial/ethnic differences in weight perception inaccuracy. This is the first study of weight perception inaccuracy to include Latino/a and Asian American adolescents.
Methods. Among the 12,789 Wave 11 participants of the National Longitudinal Study of Adolescent Health, we estimate multivariate models that reveal how gender, race/ethnicity, and clinical weight categories predict weight perception inaccuracy.
Results. Relative to boys, girls have lower odds of underestimating their weight and greater odds of overestimating their weight. In particular, among overweight and obese adolescents, girls are more accurate than boys, but among normal weight adolescents, boys are more accurate. Compared with Whites, African Americans are more likely to underestimate their weight, particularly among overweight girls and obese boys. Overall and particularly among girls and normal weight adolescents, African Americans are less likely to overestimate their weight than their White counterparts. Finally, Asian American girls are more likely to underestimate their weight than White girls.
Conclusion. These findings have important implications for identifying and intervening with adolescents at the greatest risk of long-term weight problems, weight-related morbidity, and unhealthy weight control practices.
C1 [Martin, Molly A.; Frisco, Michelle L.] Penn State Univ, Dept Sociol, University Pk, PA 16802 USA.
[Martin, Molly A.; Frisco, Michelle L.] Penn State Univ, Populat Res Inst, University Pk, PA 16802 USA.
[May, Ashleigh L.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA USA.
RP Martin, MA (reprint author), Penn State Univ, Dept Sociol, 211 Oswald Tower, University Pk, PA 16802 USA.
EM mmartin@pop.psu.edu
FU NICHD NIH HHS [R01 HD050144-03, R01 HD050144, R01-HD050144]
NR 28
TC 32
Z9 32
U1 2
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1049-3867
J9 WOMEN HEALTH ISS
JI Womens Health Iss.
PD SEP-OCT
PY 2009
VL 19
IS 5
BP 292
EP 299
DI 10.1016/j.whi.2009.05.003
PG 8
WC Public, Environmental & Occupational Health; Women's Studies
SC Public, Environmental & Occupational Health; Women's Studies
GA 498SV
UT WOS:000270164500002
PM 19733799
ER
PT J
AU Osterholt, DM
Onikpo, F
Lama, M
Deming, MS
Rowe, AK
AF Osterholt, Dawn M.
Onikpo, Faustin
Lama, Marcel
Deming, Michael S.
Rowe, Alexander K.
TI Improving pneumonia case-management in Benin: a randomized trial of a
multi-faceted intervention to support health worker adherence to
Integrated Management of Childhood Illness guidelines
SO HUMAN RESOURCES FOR HEALTH
LA English
DT Article
ID FACILITIES; CHILDREN; STRATEGY; QUALITY
AB Background: Pneumonia is a leading cause of death among children under five years of age. The Integrated Management of Childhood Illness strategy can improve the quality of care for pneumonia and other common illnesses in developing countries, but adherence to these guidelines could be improved. We evaluated an intervention in Benin to support health worker adherence to the guidelines after training, focusing on pneumonia case management.
Methods: We conducted a randomized trial. After a health facility survey in 1999 to assess health care quality before Integrated Management of Childhood Illness training, health workers received training plus either study supports (job aids, non-financial incentives and supervision of workers and supervisors) or "usual" supports. Follow-up surveys were conducted in 2001, 2002 and 2004. Outcomes were indicators of health care quality for Integrated Management-defined pneumonia. Further analyses included a graphical pathway analysis and multivariable logistic regression modelling to identify factors influencing case-management quality.
Results: We observed 301 consultations of children with non-severe pneumonia that were performed by 128 health workers in 88 public and private health facilities. Although outcomes improved in both intervention and control groups, we found no statistically significant difference between groups. However, training proceeded slowly, and low-quality care from untrained health workers diluted intervention effects. Per-protocol analyses suggested that health workers with training plus study supports performed better than those with training plus usual supports (20.4 and 19.2 percentage-point improvements for recommended treatment [p = 0.08] and "recommended or adequate" treatment [p = 0.01], respectively). Both groups tended to perform better than untrained health workers. Analyses of treatment errors revealed that incomplete assessment and difficulties processing clinical findings led to missed pneumonia diagnoses, and missed diagnoses led to inadequate treatment. Increased supervision frequency was associated with better care (odds ratio for recommended treatment = 2.1 [95% confidence interval: 1.13.9] per additional supervisory visit).
Conclusion: Integrated Management of Childhood Illness training was useful, but insufficient, to achieve high-quality pneumonia case management. Our study supports led to additional improvements, although large gaps in performance still remained. A simple graphical pathway analysis can identify specific, common errors that health workers make in the case-management process; this information could be used to target quality improvement activities, such as supervision (ClinicalTrials.gov number NCT00510679).
C1 [Osterholt, Dawn M.; Deming, Michael S.; Rowe, Alexander K.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30333 USA.
[Osterholt, Dawn M.] Cincinnati Childrens Hosp, Div Gen & Community Pediat Res, Cincinnati, OH USA.
[Onikpo, Faustin] Minist Hlth, Direct Dept Sante Publ Oueme Plateau, Porto Novo, Benin.
[Lama, Marcel] Africare Benin, Porto Novo, Benin.
RP Osterholt, DM (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30333 USA.
EM dawn.osterholt@cchmc.org; onikpoakitan@yahoo.fr;
Marcel.Lama@TheGlobalFund.org; msd1@cdc.gov; axr9@cdc.gov
NR 29
TC 15
Z9 15
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1478-4491
J9 HUM RESOUR HEALTH
JI Hum. Resour. Health
PD AUG 27
PY 2009
VL 7
AR 77
DI 10.1186/1478-4491-7-77
PG 13
WC Health Policy & Services; Industrial Relations & Labor
SC Health Care Sciences & Services; Business & Economics
GA 507XG
UT WOS:000270888500001
PM 19712484
ER
PT J
AU Shui, IM
Shi, P
Dutta-Linn, MM
Weintraub, ES
Hambidge, SJ
Nordin, JD
Lieu, TA
AF Shui, Irene M.
Shi, Ping
Dutta-Linn, M. Maya
Weintraub, Eric S.
Hambidge, Simon J.
Nordin, James D.
Lieu, Tracy A.
CA Vaccine Safety Datalink Res Team
TI Predictive value of seizure ICD-9 codes for vaccine safety research
SO VACCINE
LA English
DT Article
DE Vaccine safety; Seizures; Positive predictive value
ID HEALTHY-CHILDREN; DATALINK PROJECT; IMMUNIZATION; SURVEILLANCE;
PERTUSSIS; RUBELLA; MEASLES; EVENTS; MUMPS; RISK
AB Post-licensure vaccine safety studies often monitor for seizures using automated screening of ICD-9 codes. This study assessed the positive predictive value (PPV) of ICD-9 codes used to identify seizure visits in children aged 6 weeks to 23 months who were enrolled in seven managed care organizations during January 2000 to December 2005. ICD-9 codes were used to identify visits for seizures in the 0-30-day period following receipt of a pneumococcal vaccine. Visits were stratified by setting of diagnosis (emergency department (ED), outpatient, and inpatient). Review of medical records confirmed whether the visit represented a true acute seizure event. 3233 visits for seizures were identified; 1024 were randomly selected for medical record review and 859 (84%) had records available. The PPV of ICD-9 codes was highest in the ED setting (97%), followed by the inpatient setting (64%). In the outpatient setting, computerized codes for seizures had very low PPV: 16% on days 1-30 following vaccination and 2% for visits on the same day of vaccination. An estimated 77% of true seizures identified were from the ED or inpatient settings. In conclusion, when using ICD-9 codes to identify seizure outcomes, restricting to the ED and inpatient settings of diagnosis may result in less biased preliminary analyses and more efficient vaccine safety studies. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Shui, Irene M.; Shi, Ping; Dutta-Linn, M. Maya; Lieu, Tracy A.] Harvard Pilgrim Hlth Care, Dept Ambulatory Care & Prevent, Boston, MA 02215 USA.
[Weintraub, Eric S.] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA 30333 USA.
[Hambidge, Simon J.] Kaiser Permanente Colorado, Inst Hlth Res, Denver, CO USA.
[Hambidge, Simon J.] Denver Hlth, Community Hlth Pediat, Denver, CO USA.
[Nordin, James D.] HealthPartners Res Fdn, Minneapolis, MN USA.
[Lieu, Tracy A.] Childrens Hosp, Div Gen Pediat, Boston, MA 02115 USA.
RP Shui, IM (reprint author), Harvard Pilgrim Hlth Care, Dept Ambulatory Care & Prevent, 133 Brookline Ave,6th Floor, Boston, MA 02215 USA.
EM irene_shui@hphc.org
FU Centers for Disease Control and Prevention (CDC) [200-2002-00732]
FX This study was funded through a subcontract with America's Health
Insurance Plans (AHIP) under contract 200-2002-00732 from the Centers
for Disease Control and Prevention (CDC).
NR 19
TC 28
Z9 28
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD AUG 27
PY 2009
VL 27
IS 39
BP 5307
EP 5312
DI 10.1016/j.vaccine.2009.06.092
PG 6
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 492BT
UT WOS:000269629800004
PM 19616500
ER
PT J
AU Lynch, MF
Blanton, EM
Bulens, S
Polyak, C
Vojdani, J
Stevenson, J
Medalla, F
Barzilay, E
Joyce, K
Barrett, T
Mintz, ED
AF Lynch, Michael F.
Blanton, Elizabeth M.
Bulens, Sandra
Polyak, Christina
Vojdani, Jazmin
Stevenson, Jennifer
Medalla, Felicia
Barzilay, Ezra
Joyce, Kevin
Barrett, Timothy
Mintz, Eric Daniel
TI Typhoid Fever in the United States, 1999-2006
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID RESISTANT SALMONELLA-TYPHI; ENTERICA SEROTYPE TYPHI;
ANTIMICROBIAL-RESISTANCE; DRUG-RESISTANCE; INFECTIONS; COUNTRIES;
BURDEN; TRAVEL; INDIA
AB Context Typhoid fever in the United States has increasingly been due to infection with antimicrobial-resistant Salmonella ser Typhi. National surveillance for typhoid fever can inform prevention and treatment recommendations.
Objective To assess trends in infections with antimicrobial-resistant S Typhi.
Design Cross-sectional, laboratory-based surveillance study.
Setting and Participants We reviewed data from 1999-2006 for 1902 persons with typhoid fever who had epidemiologic information submitted to the Centers for Disease Control and Prevention (CDC) and 2016 S Typhi isolates sent by participating public health laboratories to the National Antimicrobial Resistance Monitoring System Laboratory at the CDC for antimicrobial susceptibility testing.
Main Outcome Measures Proportion of S Typhi isolates demonstrating resistance to 14 antimicrobial agents and patient risk factors for antimicrobial-resistant infections.
Results Patient median age was 22 years (range, <1-90 years); 1295 (73%) were hospitalized and 3 (0.2%) died. Foreign travel within 30 days of illness was reported by 1439 (79%). Only 58 travelers (5%) had received typhoid vaccine. Two hundred seventy-two (13%) of 2016 isolates tested were resistant to ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole (multidrug-resistant S Typhi [MDRST]); 758 (38%) were resistant to nalidixic acid (nalidixic acid-resistant S Typhi [NARST]) and 734 NARST isolates (97%) had decreased susceptibility to ciprofloxacin. The proportion of NARST increased from 19% in 1999 to 54% in 2006. Five ciprofloxacin-resistant isolates were identified. Patients with resistant infections were more likely to report travel to the Indian subcontinent: 85% of patients infected with MDRST and 94% with NARST traveled to the Indian subcontinent, while 44% of those with susceptible infections did (MDRST odds ratio, 7.5; 95% confidence interval, 4.1-13.8; NARST odds ratio, 20.4; 95% confidence interval, 12.4-33.9).
Conclusion Infection with antimicrobial-resistant S Typhi strains among US patients with typhoid fever is associated with travel to the Indian subcontinent, and an increasing proportion of these infections are due to S Typhi strains with decreased susceptibility to fluoroquinolones. JAMA. 2009; 302(8): 859-865
C1 [Lynch, Michael F.; Blanton, Elizabeth M.; Bulens, Sandra; Polyak, Christina; Vojdani, Jazmin; Stevenson, Jennifer; Medalla, Felicia; Barzilay, Ezra; Mintz, Eric Daniel] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vectorborne & Enter Dis, Enter Dis Epidemiol Branch, Atlanta, GA 30341 USA.
[Joyce, Kevin; Barrett, Timothy] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vectorborne & Enter Dis, Enter Dis Lab Branch, Atlanta, GA 30341 USA.
[Barrett, Timothy] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vectorborne & Enter Dis, Div Foodborne Bacterial & Mycot Dis, Atlanta, GA 30341 USA.
[Barrett, Timothy] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vectorborne & Enter Dis, Off Chief Sci Officer, Atlanta, GA 30341 USA.
RP Lynch, MF (reprint author), Ctr Dis Control & Prevent, Natl Ctr Zoonot Vectorborne & Enter Dis, Enter Dis Epidemiol Branch, 4770 Buford Hwy,MS F-22, Atlanta, GA 30341 USA.
EM mlynch1@cdc.gov
OI Duque, Jazmin/0000-0003-3484-276X
NR 25
TC 82
Z9 87
U1 0
U2 6
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD AUG 26
PY 2009
VL 302
IS 8
BP 859
EP 865
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA 487GN
UT WOS:000269260100019
PM 19706859
ER
PT J
AU Crepaz, N
Marks, G
Liau, A
Mullins, MM
Aupont, LW
Marshall, KJ
Jacobs, ED
Wolitski, RJ
AF Crepaz, Nicole
Marks, Gary
Liau, Adrian
Mullins, Mary M.
Aupont, Latrina W.
Marshall, Khiya J.
Jacobs, Elizabeth D.
Wolitski, Richard J.
CA HIV AIDS Prevention Res Synth Team
TI Prevalence of unprotected anal intercourse among HIV-diagnosed MSM in
the United States: a meta-analysis
SO AIDS
LA English
DT Review
DE HIV/AIDS; men who have sex with men; people living with HIV;
serosorting; strategic positioning; unprotected sex
ID SEXUAL RISK BEHAVIOR; ACTIVE ANTIRETROVIRAL THERAPY; NEW-YORK-CITY;
TRANSMISSION RISK; BISEXUAL MEN; POSITIVE MEN; GAY MEN; MULTICLINIC
ASSESSMENT; PREVENTION STRATEGIES; SEROPOSITIVE MEN
AB Objective: To integrate the empirical findings on the prevalence of unprotected anal intercourse (UAI) among HIV-diagnosed men who have sex with men (MSM) in the United States.
Methods: Comprehensively searching MEDLINE, EMBASE, PsycINFO (2000-2007), hand searching bibliographic lists, and contacting researchers. Thirty US studies (n = 18 121) met selection criteria. Analyses were conducted using random-effects models and meta-regress ion.
Results: The prevalence of UAI was considerably higher with HIV-seropositive partners (30%; 95% confidence interval 25-36) than with serostatus unknown (16%; 95% confidence interval 13-21) or HIV-seronegative partners (13%; 95% confidence interval 10-16). The prevalence of UAI with either a serostatus unknown or HIV-seronegative partner was 26%. The UAI prevalence did not differ by the length of the behavioral recall window but did vary by the type of anal intercourse (insertive vs. receptive). Studies with the following features had a lower UAI prevalence: recruiting participants before 2000, MSM of color being the majority of study sample, recruiting participants from medical settings, using random or systematic sampling methods, and having interviewers administer the questionnaire. Being on antiretroviral therapy, having an undetectable viral load, and reporting more than 90% medication adherence were not associated with UAI.
Conclusion: Most HIV-diagnosed MSM protect partners during sexual activity, but a sizeable percentage continues to engage in sexual behaviors that place others at risk for HIV infection and place themselves at risk for other sexually transmitted infections. Prevention with positives programs continues to be urgently needed for MSM in the United States. (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins
C1 [Crepaz, Nicole] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Prevent Res Branch, Atlanta, GA 30333 USA.
RP Crepaz, N (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Prevent Res Branch, 1600 Clifton Rd,Mailstop E-37, Atlanta, GA 30333 USA.
EM ncrepaz@cdc.gov
FU Prevention Research Branch, Division of HIV/AIDS Prevention, U.S. CDC
FX We sincerely thank the following authors for providing additional data
to assist our coding and analyses: Angela Aidala; IDavid S. Bimbi;
Cherilyn K. Bingnian; Michael Canipsinith; Sanny Y. Chen; Shonda M.
Craft; Paul Denning; Ralph DiClemente; Helen Ding; Theresa Exner; Ellen
Funkhouser; Lytt Gardner; Christian Grov; Perry N. Halkitis; Bell
Hadsock; IDavid HoItgrave; Charlotte Kent; Andrea Y. Kim; Robert
Klitzman; Gordon Mansergh; Gary Marks; Wilh McFarland; Stephen Morin;
Joanne Mullen; Dennis H. Osmond; David E. Ostrow; Jeffrey T. Parsons;
Lance M. Pollack: Paul J. Poppen; Michael Reece; jean L Richardson;
Starley Sliadel- Peter Theodore; Peter Vanable; Lance S. Weinhardt;
William L. H. Whittington, Richard Wolitski. No compensation was
received for any contributions made by these individuals.
NR 69
TC 134
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U1 3
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0269-9370
J9 AIDS
JI Aids
PD AUG 24
PY 2009
VL 23
IS 13
BP 1617
EP 1629
DI 10.1097/QAD.0b013e32832effae
PG 13
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 488FF
UT WOS:000269333900001
PM 19584704
ER
PT J
AU Prabhu, VS
Hutchinson, AB
Farnham, PG
Sansom, SL
AF Prabhu, Vimalanand S.
Hutchinson, Angela B.
Farnham, Paul G.
Sansom, Stephanie L.
TI Sexually acquired HIV infections in the United States due to acute-phase
HIV transmission: an update
SO AIDS
LA English
DT Letter
ID EPIDEMICS; USA
C1 [Prabhu, Vimalanand S.; Hutchinson, Angela B.; Farnham, Paul G.; Sansom, Stephanie L.] Ctr Dis Control & Prevent, Div HIV AIDS, NCHHSTP, Atlanta, GA 30333 USA.
RP Prabhu, VS (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS, NCHHSTP, Atlanta, GA 30333 USA.
NR 10
TC 30
Z9 30
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0269-9370
EI 1473-5571
J9 AIDS
JI Aids
PD AUG 24
PY 2009
VL 23
IS 13
BP 1792
EP 1794
DI 10.1097/QAD.0b013e32832e7d04
PG 3
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 488FF
UT WOS:000269333900023
PM 19684485
ER
PT J
AU Koontz, DA
Huckins, JJ
Spencer, A
Gallagher, ML
AF Koontz, Deborah A.
Huckins, Jacqueline J.
Spencer, Antonina
Gallagher, Margaret L.
TI Rapid detection of the CYP2A6*12 hybrid allele by Pyrosequencing (R)
technology
SO BMC MEDICAL GENETICS
LA English
DT Article
ID NICOTINE METABOLISM; CYP2A6; GENE; POLYMORPHISMS; ASSOCIATION;
CAUCASIANS; SMOKING; PCR
AB Background: Identification of CYP2A6 alleles associated with reduced enzyme activity is important in the study of inter-individual differences in drug metabolism. CYP2A6*12 is a hybrid allele that results from unequal crossover between CYP2A6 and CYP2A7 genes. The 5' regulatory region and exons 1-2 are derived from CYP2A7, and exons 3-9 are derived from CYP2A6. Conventional methods for detection of CYP2A6*12 consist of two-step PCR protocols that are laborious and unsuitable for high-throughput genotyping. We developed a rapid and accurate method to detect the CYP2A6*12 allele by Pyrosequencing technology.
Methods: A single set of PCR primers was designed to specifically amplify both the CYP2A6*1 wildtype allele and the CYP2A6*12 hybrid allele. An internal Pyrosequencing primer was used to generate allele-specific sequence information, which detected homozygous wild-type, heterozygous hybrid, and homozygous hybrid alleles. We first validated the assay on 104 DNA samples that were also genotyped by conventional two-step PCR and by cycle sequencing. CYP2A6*12 allele frequencies were then determined using the Pyrosequencing assay on 181 multi-ethnic DNA samples from subjects of African American, European Caucasian, Pacific Rim, and Hispanic descent. Finally, we streamlined the Pyrosequencing assay by integrating liquid handling robotics into the workflow.
Results: Pyrosequencing results demonstrated 100% concordance with conventional two-step PCR and cycle sequencing methods. Allele frequency data showed slightly higher prevalence of the CYP2A6*12 allele in European Caucasians and Hispanics.
Conclusion: This Pyrosequencing assay proved to be a simple, rapid, and accurate alternative to conventional methods, which can be easily adapted to the needs of higher-throughput studies.
C1 [Koontz, Deborah A.; Gallagher, Margaret L.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Huckins, Jacqueline J.; Spencer, Antonina] Qiagen Inc, Germantown, MD 20874 USA.
RP Koontz, DA (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Hwy NE, Atlanta, GA 30341 USA.
EM duk5@cdc.gov; jacki.huckins@qiagen.com; antonina.spencer@qiagen.com;
mxg2@cdc.gov
FU Research Participation Program at CDC; U.S. Department of Energy
administered by Oak Ridge Institute for Science and Education
FX We would like to thank Stanimila Nikolova for her technical assistance
in confirming the CYP2A6*12 homozygote samples. Jacqueline Huckins and
Antonina Spencer were funded by the Research Participation Program at
CDC, an inter-agency agreement with the U.S. Department of Energy
administered by Oak Ridge Institute for Science and Education. This work
was funded through allocations for the Centers for Disease Control and
Prevention, Division of Laboratory Sciences.
NR 17
TC 4
Z9 4
U1 1
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2350
J9 BMC MED GENET
JI BMC Med. Genet.
PD AUG 24
PY 2009
VL 10
AR 80
DI 10.1186/1471-2350-10-80
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 491FT
UT WOS:000269564100001
PM 19703308
ER
PT J
AU Khetsuriani, N
Helfand, R
Pallansch, M
Kew, O
Fowlkes, A
Oberste, MS
Tukei, P
Muli, J
Makokha, E
Gary, H
AF Khetsuriani, Nino
Helfand, Rita
Pallansch, Mark
Kew, Olen
Fowlkes, Ashley
Oberste, M. Steven
Tukei, Peter
Muli, Joseph
Makokha, Ernest
Gary, Howard
TI Limited duration of vaccine poliovirus and other enterovirus excretion
among human immunodeficiency virus infected children in Kenya
SO BMC INFECTIOUS DISEASES
LA English
DT Article
ID PARALYTIC POLIOMYELITIS; HIV-INFECTION; SOUTH-AFRICA; TYPE-1;
ERADICATION; PCR; IDENTIFICATION; PERSISTENCE; DIARRHEA; ISSUES
AB Background: Immunodeficient persons with persistent vaccine-related poliovirus infection may serve as a potential reservoir for reintroduction of polioviruses after wild poliovirus eradication, posing a risk of their further circulation in inadequately immunized populations.
Methods: To estimate the potential for vaccine-related poliovirus persistence among HIV-infected persons, we studied poliovirus excretion following vaccination among children at an orphanage in Kenya. For 12 months after national immunization days, we collected serial stool specimens from orphanage residents aged <5 years at enrollment and recorded their HIV status and demographic, clinical, immunological, and immunization data. To detect and characterize isolated polioviruses and non-polio enteroviruses (NPEV), we used viral culture, typing and intratypic differentiation of isolates by PCR, ELISA, and nucleic acid sequencing. Long-term persistence was defined as shedding for = 6 months.
Results: Twenty-four children (15 HIV-infected, 9 HIV-uninfected) were enrolled, and 255 specimens (170 from HIV-infected, 85 from HIV-uninfected) were collected. All HIV-infected children had mildly or moderately symptomatic HIV-disease and moderate-to-severe immunosuppression. Fifteen participants shed vaccine-related polioviruses, and 22 shed NPEV at some point during the study period. Of 46 poliovirus-positive specimens, 31 were from HIV-infected, and 15 from HIV-uninfected children. No participant shed polioviruses for = 6 months. Genomic sequencing of poliovirus isolates did not reveal any genetic evidence of long-term shedding. There was no long-term shedding of NPEV.
Conclusion: The results indicate that mildly to moderately symptomatic HIV-infected children retain the ability to clear enteroviruses, including vaccine-related poliovirus. Larger studies are needed to confirm and generalize these findings.
C1 [Khetsuriani, Nino; Helfand, Rita; Pallansch, Mark; Kew, Olen; Fowlkes, Ashley; Oberste, M. Steven; Gary, Howard] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Tukei, Peter; Muli, Joseph; Makokha, Ernest] Kenya Govt Med Res Ctr, Nairobi, Kenya.
RP Khetsuriani, N (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
EM nck7@cdc.gov; RHelfand@cdc.gov; MPallansch@cdc.gov; OKew@cdc.gov;
ahl4@cdc.gov; SOberste@cdc.gov; PTukei@kemri.org; PTukei@kemri.org;
epmakokha@ke.cdc.gov; HGary@cdc.gov
NR 37
TC 13
Z9 14
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD AUG 23
PY 2009
VL 9
AR 136
DI 10.1186/1471-2334-9-136
PG 8
WC Infectious Diseases
SC Infectious Diseases
GA 501VW
UT WOS:000270412400001
PM 19698184
ER
PT J
AU Crosby, AE
Espitia-Hardeman, V
Hill, HA
Ortega, L
Clavel-Arcas, C
AF Crosby, A. E.
Espitia-Hardeman, V.
Hill, H. A.
Ortega, L.
Clavel-Arcas, C.
TI Alcohol and Suicide Among Racial/Ethnic Populations-17 States, 2005-2006
(Reprinted from MMWR, vol 58, pg 637-641, 2009)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
ID PREVENTION
C1 [Crosby, A. E.; Espitia-Hardeman, V.; Hill, H. A.; Ortega, L.; Clavel-Arcas, C.] CDC, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA.
RP Crosby, AE (reprint author), CDC, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA.
NR 10
TC 1
Z9 1
U1 1
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD AUG 19
PY 2009
VL 302
IS 7
BP 733
EP 734
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 484UT
UT WOS:000269073800009
ER
PT J
AU Slade, BA
Leidel, L
Vellozzi, C
Woo, EJ
Hua, W
Sutherland, A
Izurieta, HS
Ball, R
Miller, N
Braun, MM
Markowitz, LE
Iskander, J
AF Slade, Barbara A.
Leidel, Laura
Vellozzi, Claudia
Woo, Emily Jane
Hua, Wei
Sutherland, Andrea
Izurieta, Hector S.
Ball, Robert
Miller, Nancy
Braun, M. Miles
Markowitz, Lauri E.
Iskander, John
TI Postlicensure Safety Surveillance for Quadrivalent Human Papillomavirus
Recombinant Vaccine
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID GUILLAIN-BARRE-SYNDROME; EVENT-REPORTING-SYSTEM; UNITED-STATES; PARTICLE
VACCINE; IMMUNIZATION; SYNCOPE; DRUGS; RISK
AB Context In June 2006, the Food and Drug Administration licensed the quadrivalent human papillomavirus (types 6, 11, 16, and 18) recombinant vaccine (qHPV) in the United States for use in females aged 9 to 26 years; the Advisory Committee on Immunization Practices then recommended qHPV for routine vaccination of girls aged 11 to 12 years.
Objective To summarize reports to the Vaccine Adverse Event Reporting System (VAERS) following receipt of qHPV.
Design, Setting, and Participants Review and describe adverse events following immunization (AEFIs) reported to VAERS, a national, voluntary, passive surveillance system, from June 1, 2006, through December 31, 2008. Additional analyses were performed for some AEFIs in prelicensure trials, those of unusual severity, or those that had received public attention. Statistical data mining, including proportional reporting ratios (PRRs) and empirical Bayesian geometric mean methods, were used to detect disproportionality in reporting.
Main Outcome Measures Numbers of reported AEFIs, reporting rates (reports per 100 000 doses of distributed vaccine or per person-years at risk), and comparisons with expected background rates.
Results VAERS received 12 424 reports of AEFIs following qHPV distribution, a rate of 53.9 reports per 100 000 doses distributed. A total of 772 reports (6.2% of all reports) described serious AEFIs, including 32 reports of death. The reporting rates per 100 000 qHPV doses distributed were 8.2 for syncope; 7.5 for local site reactions; 6.8 for dizziness; 5.0 for nausea; 4.1 for headache; 3.1 for hypersensitivity reactions; 2.6 for urticaria; 0.2 for venous thromboembolic events, autoimmune disorders, and Guillain-Barre syndrome; 0.1 for anaphylaxis and death; 0.04 for transverse myelitis and pancreatitis; and 0.009 for motor neuron disease. Disproportional reporting of syncope and venous thromboembolic events was noted with data mining methods.
Conclusions Most of the AEFI rates were not greater than the background rates compared with other vaccines, but there was disproportional reporting of syncope and venous thromboembolic events. The significance of these findings must be tempered with the limitations (possible underreporting) of a passive reporting system. JAMA. 2009;302(7):750-757
C1 [Slade, Barbara A.; Leidel, Laura; Vellozzi, Claudia; Markowitz, Lauri E.; Iskander, John] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Woo, Emily Jane; Hua, Wei; Sutherland, Andrea; Izurieta, Hector S.; Ball, Robert; Miller, Nancy; Braun, M. Miles] US FDA, Washington, DC 20204 USA.
RP Slade, BA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D-26, Atlanta, GA 30333 USA.
EM bfs9@cdc.gov
FU CDC; FDA
FX The study was implemented by the Centers for Disease Control and
Prevention (CDC) and Food and Drug Administration (FDA). The only funds
used were from CDC and FDA budgets. This study had no external sponsors.
NR 33
TC 221
Z9 232
U1 1
U2 14
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD AUG 19
PY 2009
VL 302
IS 7
BP 750
EP 757
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA 484UT
UT WOS:000269073800023
PM 19690307
ER
PT J
AU Grijalva, CG
Nuorti, JP
Griffin, MR
AF Grijalva, Carlos G.
Nuorti, J. Pekka
Griffin, Marie R.
TI Antibiotic Prescription Rates for Acute Respiratory Tract Infections in
US Ambulatory Settings
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID PNEUMOCOCCAL CONJUGATE VACCINE; ACUTE OTITIS-MEDIA; RESISTANT
STREPTOCOCCUS-PNEUMONIAE; COMMUNITY-ACQUIRED PNEUMONIA; HEALTH-CARE
UTILIZATION; UNITED-STATES; CHILDHOOD IMMUNIZATION; CHANGING
EPIDEMIOLOGY; DISEASES-SOCIETY; APPROPRIATE USE
AB Context During the 1990s, antibiotic prescriptions for acute respiratory tract infection (ARTI) decreased in the United States. The sustainability of those changes is unknown.
Objective To assess trends in antibiotic prescriptions for ARTI.
Design, Setting, and Participants The National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey data (1995-2006) were used to examine trends in antibiotic prescription rates by antibiotic indication and class. Annual survey data and census denominators were combined in 2-year intervals for rate calculations.
Main Outcome Measures National annual visit rates and antibiotic prescription rates for ARTI, including otitis media (OM) and non-ARTI.
Results Among children younger than 5 years, annual ARTI visit rates decreased by 17% (95% confidence interval [CI], 9%-24%), from 1883 per 1000 population in 1995-1996 to 1560 per 1000 population in 2005-2006, primarily due to a 33% (95% CI, 22%-43%) decrease in OM visit rates (950 to 634 per 1000 population, respectively). This decrease was accompanied by a 36% (95% CI, 26%-45%) decrease in ARTI-associated antibiotic prescriptions (1216 to 779 per 1000 population). Among persons aged 5 years or older, ARTI visit rates remained stable but associated antibiotic prescription rates decreased by 18% (95% CI, 6%-29%), from 178 to 146 per 1000 population. Antibiotic prescription rates for non-OM ARTI for which antibiotics are rarely indicated decreased by 41% (95% CI, 22%-55%) and 24% (95% CI, 10%-37%) among persons younger than 5 years and 5 years or older, respectively. Overall, ARTI-associated prescription rates for penicillin, cephalosporin, and sulfonamide/tetracycline decreased. Prescription rates for azithromycin increased and it became the most commonly prescribed macrolide for ARTI and OM (10% of OM visits). Among adults, quinolone prescriptions increased.
Conclusions Overall antibiotic prescription rates for ARTI decreased, associated with fewer OM visits in children younger than 5 years and with fewer prescriptions for ARTI for which antibiotics are rarely indicated. However, prescription rates for broad-spectrum antibiotics increased significantly. JAMA. 2009;302(7):758-766
C1 [Grijalva, Carlos G.; Griffin, Marie R.] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37232 USA.
[Griffin, Marie R.] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37232 USA.
[Nuorti, J. Pekka] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
RP Grijalva, CG (reprint author), Vanderbilt Univ, Sch Med, Dept Prevent Med, 1500 21st Ave,Ste 2600, Nashville, TN 37232 USA.
EM carlos.grijalva@vanderbilt.edu
FU MedImmune; Pfizer; Centers for Disease Control and Prevention (CDC)
[TS-1392, TS-1454, K01 CI000163]
FX This study was funded by the Centers for Disease Control and Prevention
(CDC) through Cooperative Agreements with the Association for Prevention
Teaching and Research (TS-1392 and TS-1454). Dr Grijalva is supported by
a CDC career development award (K01 CI000163).
NR 53
TC 208
Z9 213
U1 3
U2 14
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD AUG 19
PY 2009
VL 302
IS 7
BP 758
EP 766
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA 484UT
UT WOS:000269073800024
PM 19690308
ER
PT J
AU Dolan, M
AF Dolan, Marc
TI Research and development of all natural, plant-derived insecticides,
pesticides, and repellents for the control of disease-vectoring
arthropods of public health importance
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Dolan, Marc] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA.
EM mcd4@cdc.gov
NR 0
TC 0
Z9 0
U1 1
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 16
PY 2009
VL 238
MA 28-AGRO
BP 379
EP 379
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16HY
UT WOS:000207861900339
ER
PT J
AU Gaunt, PS
Kalb, SR
Barr, JR
AF Gaunt, Patricia S.
Kalb, Suzanne R.
Barr, John R.
TI Catfish serum neutralization and endopep mass spectrometric assays to
detect botulinum in catfish
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Gaunt, Patricia S.] Mississippi State Univ, Thad Cochran Natl Warmwater Aquaculture Ctr, Coll Vet Med, Stoneville, MS 38776 USA.
[Kalb, Suzanne R.; Barr, John R.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
EM gaunt@cvm.msstate.edu; skalb@cdc.gov; jbb0@cdc.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 16
PY 2009
VL 238
MA 269-AGRO
BP 411
EP 411
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16HY
UT WOS:000207861900371
ER
PT J
AU Barr, JR
Kalb, SR
Moura, H
Santana, WI
Woolfitt, AR
Solano, MI
Terilli, R
Pirkle, JL
AF Barr, John R.
Kalb, Suzanne R.
Moura, Hercules
Santana, Wanda I.
Woolfitt, Adrian R.
Solano, Maria I.
Terilli, Rebecca
Pirkle, James L.
TI ANYL 281-Detection, differentiation, and subtyping of botulinum
neurotoxins with mass spectrometry
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Barr, John R.; Kalb, Suzanne R.; Moura, Hercules; Santana, Wanda I.; Woolfitt, Adrian R.; Solano, Maria I.; Terilli, Rebecca; Pirkle, James L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
EM jbb0@cdc.gov; skalb@cdc.gov; HMoura@cdc.gov; ewz4@cdc.gov;
AWoolfitt@cdc.gov; MSolano@cdc.gov; RTerrilli@cdc.gov; JPirkle@cdc.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 16
PY 2009
VL 238
MA 281-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16HY
UT WOS:000207861901146
ER
PT J
AU Dluhy, RA
Driskell, JD
Zhao, YP
Tripp, RA
Rota, P
Krause, DC
AF Dluhy, R. A.
Driskell, J. D.
Zhao, Y-P
Tripp, R. A.
Rota, P.
Krause, D. C.
TI COLL 62-Novel nanorod array substrates as a platform for SERS-based
biosensing of infectious disease
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Dluhy, R. A.] Univ Georgia, Dept Chem, Athens, GA 30602 USA.
[Driskell, J. D.; Tripp, R. A.] Univ Georgia, Dept Infect Dis, Athens, GA 30602 USA.
[Zhao, Y-P] Univ Georgia, Dept Phys & Astron, Athens, GA 30602 USA.
[Rota, P.] Ctr Dis Control, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Krause, D. C.] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA.
EM dluhy@uga.edu; jdriskel@uga.edu; zhaoy@physast.uga.edu;
rtripp@vet.uga.edu; par1@cdc.gov; dkrause@uga.edu
RI Tripp, Ralph/F-5218-2011; Zhao, Yiping/A-4968-2008
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 16
PY 2009
VL 238
MA 62-COLL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16HY
UT WOS:000207861903371
ER
PT J
AU Nguyen, JV
Panuwet, P
Wade, EL
Restrepo, P
Magsumbol, M
Montesano, A
Needham, LL
Barr, DB
AF Nguyen, Johnny V.
Panuwet, Parinya
Wade, Erin Lynn
Restrepo, Paula
Magsumbol, Melina
Montesano, Angela
Needham, Larry L.
Barr, Dana B.
TI ANYL 153-Measurement of melamine in human urine using HPLC-MS/MS
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Nguyen, Johnny V.; Panuwet, Parinya; Wade, Erin Lynn; Restrepo, Paula; Magsumbol, Melina; Montesano, Angela; Barr, Dana B.] US Ctr Dis Control & Prevent, Nonpersistent Pesticides Grp, Atlanta, GA 30341 USA.
[Needham, Larry L.] US Ctr Dis Control & Prevent, Organ Analyt Toxicol Branch, Atlanta, GA 30341 USA.
EM jdn1@cdc.gov; dlb1@cdc.gov
RI Needham, Larry/E-4930-2011; Barr, Dana/E-6369-2011; Barr,
Dana/E-2276-2013
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 16
PY 2009
VL 238
MA 153-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16HY
UT WOS:000207861901201
ER
PT J
AU Whitehead, RD
Montesano, MA
Jayatilaka, NK
Kuklenyik, P
Davis, MD
Needham, LL
Barr, DB
AF Whitehead, Ralph D., Jr.
Montesano, Maria Angela
Jayatilaka, Nayana K.
Kuklenyik, Peter
Davis, Mark D.
Needham, L. L.
Barr, Dana B.
TI ANYL 154-Measurement of ethyl methanesulfonate in human plasma and
breast milk samples using high-performance liquid
chromatography-atmospheric pressure chemical ionization tandem mass
spectrometry
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Whitehead, Ralph D., Jr.; Montesano, Maria Angela; Jayatilaka, Nayana K.; Kuklenyik, Peter; Davis, Mark D.; Barr, Dana B.] Ctr Dis Control & Prevent, NCEH ATSDR, Div Sci Lab, Organ Analyt Toxicants Branch, Atlanta, GA 30341 USA.
[Needham, L. L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
EM RNW2@cdc.gov; AHM2@cdc.gov; GOH3@cdc.gov; MSD7@cdc.gov; lln1@cdc.gov;
dbarr@cdc.gov
RI Needham, Larry/E-4930-2011; Barr, Dana/E-6369-2011; Barr,
Dana/E-2276-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD AUG 16
PY 2009
VL 238
MA 154-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16HY
UT WOS:000207861901052
ER
PT J
AU Smith, CM
Hill, VR
AF Smith, Carmela M.
Hill, Vincent R.
TI Dead-End Hollow-Fiber Ultrafiltration for Recovery of Diverse Microbes
from Water
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID DRINKING-WATER; UNITED-STATES; CRYPTOSPORIDIUM-PARVUM; RECREATIONAL
WATER; SAMPLES; DISEASE; GASTROENTERITIS; SURVEILLANCE; OOCYSTS
AB Dead-end ultrafiltration (DEUF) is an alternative approach to tangential-flow hollow-fiber ultrafiltration that can be readily employed under field conditions to recover microbes from water. The hydraulics of DEUF and microbe recovery for a new DEUF method were investigated using 100-liter tap water samples. Pressure, flow rate, and temperature were investigated using four hollow-fiber ultrafilter types. Based on hydraulic performance, the Asahi Kasei REXEED 25S ultrafilter was selected for microbe recovery experiments. Microbe recovery experiments were performed using MS2 bacteriophage, Enterococcus faecalis, Clostridium perfringens spores, and Cryptosporidium parvum oocysts. Microbes were recovered from ultrafilters by backflushing using a surfactant solution. Average flow rates were 2.1 liters/min for 100-liter water samples having turbidities of 0.28 to 4.3 nephelometric turbidity units (NTU), and no evidence of appreciable filter clogging was observed. The DEUF average recovery efficiencies for each study analyte in tap water were as follows: for E. faecalis, 93% +/- 16%; for MS2, 57% +/- 7.7%; for C. perfringens spores, 94% +/- 22%; and for C. parvum, 87% +/- 18%. Average microbe recoveries for tap water amended with surface water (average turbidity = 4.3 NTU) were as follows: for E. faecalis, 78% +/- 12%; for MS2, 73% +/- 13%; for C. perfringens, 57% +/- 21%; and for C. parvum, 83% +/- 21%. These data demonstrate that DEUF is an effective method for recovering diverse microbes from water and should be a useful tool for field-based environmental investigations.
C1 [Smith, Carmela M.; Hill, Vincent R.] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Div Parasit Dis, Atlanta, GA 30341 USA.
[Smith, Carmela M.] Atlanta Res & Educ Fdn, Decatur, GA USA.
RP Hill, VR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Div Parasit Dis, 4770 Buford Highway,Mail Stop F-36, Atlanta, GA 30341 USA.
EM vhill@cdc.gov
RI Hill, Vincent/G-1789-2012
OI Hill, Vincent/0000-0001-7069-7737
FU Disease Control and Prevention, Coordinating Office for Terrorism
Preparedness and Emergency Response
FX This publication was supported in part by funds made available through
the Centers for Disease Control and Prevention, Coordinating Office for
Terrorism Preparedness and Emergency Response.
NR 20
TC 46
Z9 49
U1 2
U2 22
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD AUG 15
PY 2009
VL 75
IS 16
BP 5284
EP 5289
DI 10.1128/AEM.00456-09
PG 6
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 479LE
UT WOS:000268660000013
PM 19561183
ER
PT J
AU O'Connell, HA
Rose, LJ
Shams, A
Bradley, M
Arduino, MJ
Rice, EW
AF O'Connell, Heather A.
Rose, Laura J.
Shams, Alicia
Bradley, Meranda
Arduino, Matthew J.
Rice, Eugene W.
TI Variability of Burkholderia pseudomallei Strain Sensitivities to
Chlorine Disinfection
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID ESCHERICHIA-COLI O157-H7; RUGOSE SURVIVAL FORM; POTABLE WATER;
DRINKING-WATER; MELIOIDOSIS; INACTIVATION; VIBRIO-CHOLERAE-01;
MONOCHLORAMINE; RESISTANCE; BIOFILMS
AB Burkholderia pseudomallei is a select agent and the causative agent of melioidosis. Variations in previously reported chlorine and monochloramine concentration time (Ct) values for disinfection of this organism make decisions regarding the appropriate levels of chlorine in water treatment systems difficult. This study identified the variation in Ct values for 2-, 3-, and 4-log(10) reductions of eight environmental and clinical isolates of B. pseudomallei in phosphate-buffered water. The greatest calculated Ct values for a 4-log(10) inactivation were 7.8 mg.min/liter for free available chlorine (FAC) at pH 8 and 5 degrees C and 550 mg.min/liter for monochloramine at pH 8 and 5 C. Ionic strength of test solutions, culture hold times in water, and cell washing were ruled out as sources of the differences in prior observations. Tolerance to FAC was correlated with the relative amount of extracellular material produced by each isolate. Solid-phase cytometry analysis using an esterase-cleaved fluorochrome assay detected a 2-log(10)-higher level of organisms based upon metabolic activity than did culture, which in some cases increased Ct values by fivefold. Despite strain-to-strain variations in Ct values of 17-fold for FAC and 2.5-fold for monochloramine, standard FAC disinfection practices utilized in the United States should disinfect planktonic populations of these B. pseudomallei strains by 4 orders of magnitude in less than 10 min at the tested temperatures and pH levels.
C1 [O'Connell, Heather A.; Rose, Laura J.; Shams, Alicia; Bradley, Meranda; Arduino, Matthew J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Rice, Eugene W.] US EPA, Cincinnati, OH 45268 USA.
RP O'Connell, HA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS C-16, Atlanta, GA 30333 USA.
EM ftw2@cdc.gov
FU Oak Ridge Institute of Science and Engineering
FX This research was made possible by an intraagency agreement between the
EPA and the CDC. This research was supported in part by an appointment
to the Research Participation Program at the CDC administered by the Oak
Ridge Institute of Science and Engineering through an intraagency
agreement between the DOE and the CDC.
NR 36
TC 8
Z9 8
U1 0
U2 8
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD AUG 15
PY 2009
VL 75
IS 16
BP 5405
EP 5409
DI 10.1128/AEM.00062-09
PG 5
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 479LE
UT WOS:000268660000028
PM 19542324
ER
PT J
AU Morpeth, SC
Ramadhani, HO
Crump, JA
AF Morpeth, Susan C.
Ramadhani, Habib O.
Crump, John A.
TI Invasive Non-Typhi Salmonella Disease in Africa
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID MALAWIAN CHILDREN; BACTERIAL-INFECTIONS; CLINICAL-FEATURES;
TYPHOID-FEVER; BACTEREMIA; ADULTS; HIV; TYPHIMURIUM; RESISTANCE; RISK
AB Invasive non-Typhi Salmonella is endemic to sub-Saharan Africa, where it is a leading cause of bloodstream infection. Some host risk factors have been established, but little is known about environmental reservoirs and predominant modes of transmission, so prevention strategies are underdeveloped. Although foodborne transmission from animals to humans predominates in high-income countries, it has been postulated that transmission between humans, both within and outside health care facilities, may be important in sub-Saharan Africa. Antimicrobial resistance to ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol is common among non-Typhi Salmonella strains; therefore, wider use of alternative agents may be warranted for empirical therapy. Development of vaccines targeting the leading invasive non-Typhi Salmonella serotypes Typhimurium and Enteritidis is warranted. The clinical presentation of non-Typhi Salmonella bacteremia is nonspecific and, in the absence of blood culture, may be confused with other febrile illnesses, such as malaria. Much work remains to be done to understand and control invasive non-Typhi Salmonella disease in sub-Saharan Africa.
C1 [Morpeth, Susan C.; Crump, John A.] Duke Univ, Med Ctr, Div Infect Dis & Int Hlth, Dept Med, Durham, NC 27710 USA.
[Crump, John A.] Duke Univ, Duke Global Hlth Inst, Durham, NC 27710 USA.
[Crump, John A.] Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA USA.
[Morpeth, Susan C.; Ramadhani, Habib O.; Crump, John A.] Tumaini Univ, Kilimanjaro Christian Med Ctr, Moshi, Tanzania.
[Ramadhani, Habib O.; Crump, John A.] Tumaini Univ, Kilimanjaro Christian Med Coll, Moshi, Tanzania.
[Morpeth, Susan C.] Royal Brisbane & Womens Hosp, Pathol Queensland Cent Lab, Brisbane, Qld, Australia.
RP Crump, JA (reprint author), Duke Univ, Med Ctr, Div Infect Dis & Int Hlth, Dept Med, Box 102359, Durham, NC 27710 USA.
EM crump017@mc.duke.edu
FU AIDS International Training and Research Program, Fogarty International
Center [D43 PA-03-018]; International Studies of AIDS-associated
Co-infections [AI062563]; Duke University Center for AIDS Research
[AI64518]; Duke Clinical Trials Unit and Clinical Research Sites
[AI069484-01]; Hubert-Yeargan Center for Global Health; Duke Clinical
Research Institute Synderman Award, Duke University Medical Center
FX US National Institutes of Health awards: AIDS International Training and
Research Program, Fogarty International Center (D43 PA-03-018 to H. O.
R. and J. A. C.), International Studies of AIDS-associated Co-infections
(AI062563 to H. O. R. and J. A. C.), the Duke University Center for AIDS
Research (AI64518 to H. O. R. and J. A. C.), and the Duke Clinical
Trials Unit and Clinical Research Sites (AI069484-01 to J. A. C.); the
Hubert-Yeargan Center for Global Health and a Duke Clinical Research
Institute Synderman Award, Duke University Medical Center (to S. C. M.).
NR 51
TC 106
Z9 108
U1 0
U2 16
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD AUG 15
PY 2009
VL 49
IS 4
BP 606
EP 611
DI 10.1086/603553
PG 6
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 472UI
UT WOS:000268157300018
PM 19591599
ER
PT J
AU Kittikraisak, W
van Griensven, F
Martin, M
McNicholl, J
Gilbert, PB
Chuachoowong, R
Vanichseni, S
Sutthent, R
Tappero, JW
Mastro, TD
Hu, DJ
Gurwith, M
Kitayaporn, D
Sangkum, U
Choopanya, K
AF Kittikraisak, Wanitchaya
van Griensven, Frits
Martin, Michael
McNicholl, Janet
Gilbert, Peter B.
Chuachoowong, Rutt
Vanichseni, Suphak
Sutthent, Ruengpung
Tappero, Jordan W.
Mastro, Timothy D.
Hu, Dale J.
Gurwith, Marc
Kitayaporn, Dwip
Sangkum, Udomsak
Choopanya, Kachit
TI Blood and Seminal Plasma HIV-1 RNA Levels Among HIV-1-Infected Injecting
Drug Users Participating in the AIDSVAX B/E Efficacy Trial in Bangkok,
Thailand
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article; Proceedings Paper
CT 48th Annual Interscience Conference on Antimicrobial Agents and
Chemotherapy/46th Annual Meeting of the
Infectious-Diseases-Society-of-America
CY OCT 25, 2008
CL Washington, DC
SP Infect Dis Soc Amer
DE HIV-1 RNA viral load; HIV-1 vaccine; injecting drug users
ID RECOMBINANT GLYCOPROTEIN-120 VACCINE; VIRAL LOAD; DISEASE PROGRESSION;
PROSPECTIVE COHORT; LONGITUDINAL DATA; DOUBLE-BLIND; TYPE-1; INFECTION;
TRANSMISSION; REPLICATION
AB Background: We investigated effects of vaccination with AIDSVAX B/E HIV-1 candidate vaccine on blood and seminal plasma HIV-1 RNA viral loads (BVL and SVL, respectively) in vaccine recipients (VRs) and placebo recipients (PRs) who acquired infection.
Methods: Linear mixed models were fitted for repeated measurements of BVL. Generalized estimating equations were used to assess the difference ill SVL detectability between VRs and PRs.
Results: A total of 196 participants became HIV-1 infected during the trial. Thirty-two (16%) became infected with HIV-1 subtype B and 164 (84%) with HIV-1 Subtype CRF01_AE. Per protocol-specified analysis, there were no differences in BVL levels between VRs and PRs. When stratified by HIV-1-infecting subtype, vaccination with AIDSVAX B/E was initially associated with higher BVL among HIV-1 CRF01_AE-infected VRs compared with HIV-1 CRF01_AE-infected PRs; however, this difference did not persist over time. HIV-1 subtype B-infected VRs had slightly higher BVL levels and were more likely to have detectable SVL during the followup period than HIV-1 subtype B-infected PRs.
Conclusions: Subtle differences in BVL and SVL were detected between VRs and PRs. These results may help to further understand the dynamics between HIV-1 vaccination, HIV-1-infecting Subtypes, and subsequent viral expression in different body compartments.
C1 [Kittikraisak, Wanitchaya; van Griensven, Frits; Martin, Michael; McNicholl, Janet; Chuachoowong, Rutt] US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Nonthaburi, Thailand.
[van Griensven, Frits; Martin, Michael; McNicholl, Janet; Tappero, Jordan W.; Mastro, Timothy D.; Hu, Dale J.] Ctr Dis Control & Prevent, Natl Ctr HIV STD & TB Prevent, Atlanta, GA USA.
[Gilbert, Peter B.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
[Gilbert, Peter B.] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA.
[Chuachoowong, Rutt; Sutthent, Ruengpung] Mahidol Univ, Siriraj Hosp, Dept Microbiol, Bangkok 10700, Thailand.
[Vanichseni, Suphak; Choopanya, Kachit] Bangkok Vaccine Evaluat Grp, Bangkok, Thailand.
[Gurwith, Marc] VaxGen Inc, San Francisco, CA USA.
[Kitayaporn, Dwip] Mahidol Univ, Fac Trop Med, Vaccine Trial Ctr, Bangkok, Thailand.
[Sangkum, Udomsak] Bangkok Metropolitan Adm, Bangkok, Thailand.
RP Kittikraisak, W (reprint author), POB 139, Nonthaburi 11000, Thailand.
EM wanitchayak@th.cdc.gov
RI van Griensven, Frits/G-4719-2013
OI van Griensven, Frits/0000-0002-0971-2843
FU FIC NIH HHS [D43 TW000003, D43-TW00003, D43 TW000003-20]
NR 39
TC 4
Z9 4
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD AUG 15
PY 2009
VL 51
IS 5
BP 601
EP 608
PG 8
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 475GM
UT WOS:000268346600014
PM 19430307
ER
PT J
AU Jackson, S
Van Hoeven, N
Chen, LM
Maines, TR
Cox, NJ
Katz, JM
Donis, RO
AF Jackson, Sara
Van Hoeven, Neal
Chen, Li-Mei
Maines, Taronna R.
Cox, Nancy J.
Katz, Jacqueline M.
Donis, Ruben O.
TI Reassortment between Avian H5N1 and Human H3N2 Influenza Viruses in
Ferrets: a Public Health Risk Assessment
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID LOWER RESPIRATORY-TRACT; A VIRUSES; RECEPTOR SPECIFICITY; PANDEMIC
INFLUENZA; MOLECULAR-BASIS; MATRIX PROTEIN; HIGH VIRULENCE; HUMAN
AIRWAY; HONG-KONG; TRANSMISSION
AB This study investigated whether transmissible H5 subtype human-avian reassortant viruses could be generated in vivo. To this end, ferrets were coinfected with recent avian H5N1 (A/Thailand/16/04) and human H3N2 (A/Wyoming/3/03) viruses. Genotype analyses of plaque-purified viruses from nasal secretions of coinfected ferrets revealed that approximately 9% of recovered viruses contained genes from both progenitor viruses. H5 and H3 subtype viruses, including reassortants, were found in airways extending toward and in the upper respiratory tract of ferrets. However, only parental H5N1 genotype viruses were found in lung tissue. Approximately 34% of the recovered reassortant viruses possessed the H5 hemagglutinin (HA) gene, with five unique H5 subtypes recovered. These H5 reassortants were selected for further studies to examine their growth and transmissibility characteristics. Five H5 viruses with representative reassortant genotypes showed reduced titers in nasal secretions of infected ferrets compared to the parental H5N1 virus. No transmission by direct contact between infected and naive ferrets was observed. These studies indicate that reassortment between H5N1 avian influenza and H3N2 human viruses occurred readily in vivo and furthermore that reassortment between these two viral subtypes is likely to occur in ferret upper airways. Given the relatively high incidence of reassortant viruses from tissues of the ferret upper airway, it is reasonable to conclude that continued exposure of humans and animals to H5N1 alongside seasonal influenza viruses increases the risk of generating H5 subtype reassortant viruses that may be shed from upper airway secretions.
C1 [Donis, Ruben O.] Ctr Dis Control & Prevent, Influenza Div, NCIRD, CCID, Atlanta, GA 30333 USA.
RP Donis, RO (reprint author), Ctr Dis Control & Prevent, Influenza Div, NCIRD, CCID, Mail Stop G-16,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM rvd6@cdc.gov
FU National Vaccine Program Office, Department of Health and Human Services
[04FED09438-06]; Oak Ridge Institute of Science and Education, Oak
Ridge, TN
FX This research was supported in part by the National Vaccine Program
Office, Department of Health and Human Services, agreement
04FED09438-06. Sara Jackson and Neal Van Hoeven received financial
support for this work from the Oak Ridge Institute of Science and
Education, Oak Ridge, TN.
NR 54
TC 67
Z9 68
U1 1
U2 6
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD AUG 15
PY 2009
VL 83
IS 16
BP 8131
EP 8140
DI 10.1128/JVI.00534-09
PG 10
WC Virology
SC Virology
GA 473LR
UT WOS:000268208700031
PM 19493997
ER
PT J
AU Song, HC
Wan, HQ
Araya, Y
Perez, DR
AF Song, Haichen
Wan, Hongquan
Araya, Yonas
Perez, Daniel R.
TI Partial direct contact transmission in ferrets of a mallard H7N3
influenza virus with typical avian-like receptor specificity
SO VIROLOGY JOURNAL
LA English
DT Article
ID AIRWAY EPITHELIAL-CELLS; A VIRUS; BRITISH-COLUMBIA; JAPANESE-QUAIL;
HUMAN-BEINGS; HOST-RANGE; REPLICATION; ADAPTATION; CHICKENS; H5N1
AB Background: Avian influenza viruses of the H7 subtype have caused multiple outbreaks in domestic poultry and represent a significant threat to public health due to their propensity to occasionally transmit directly from birds to humans. In order to better understand the cross species transmission potential of H7 viruses in nature, we performed biological and molecular characterizations of an H7N3 virus isolated from mallards in Canada in 2001.
Results: Sequence analysis that the HA gene of the mallard H7N3 virus shares 97% identity with the highly pathogenic avian influenza (HPAI) H7N3 virus isolated from a human case in British Columbia, Canada in 2004. The mallard H7N3 virus was able to replicate in quail and chickens, and transmitted efficiently in quail but not in chickens. Interestingly, although this virus showed preferential binding to analogs of avian-like receptors with sialic acid (SA) linked to galactose in an alpha 2-3 linkage (SA alpha 2-3Gal), it replicated to high titers in cultures of primary human airway epithelial (HAE) cells, comparable to an avian H9N2 influenza virus with human-like alpha 2-6 linkage receptors (SA alpha 2-6Gal). In addition, the virus replicated in mice and ferrets without prior adaptation and was able to transmit partially among ferrets.
Conclusion: Our findings highlight the importance and need for systematic in vitro and in vivo analysis of avian influenza viruses isolated from the natural reservoir in order to define their zoonotic potential.
C1 [Song, Haichen; Wan, Hongquan; Araya, Yonas; Perez, Daniel R.] Univ Maryland, Dept Vet Med, College Pk, MD 20742 USA.
[Song, Haichen; Wan, Hongquan; Araya, Yonas; Perez, Daniel R.] Virginia Maryland Reg Coll Vet Med, College Pk, MD 20742 USA.
[Song, Haichen] Synbiotics Corp, College Pk, MD 20742 USA.
[Wan, Hongquan] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA.
RP Perez, DR (reprint author), Univ Maryland, Dept Vet Med, 8075 Greenmead Dr, College Pk, MD 20742 USA.
EM dperez1@umd.edu
OI Perez, Daniel/0000-0002-6569-5689
FU National Institute of General Medical Sciences [GM62116]; CDC-HHS
[1U01CI000355]; NIAID-NIH [R01AI052155, HHSN266200700010C]; CSREES-USDA
[2005-05523]
FX We are indebted to Erin Sorrell and Ivan Gomez-Osorio for their
excellent animal handling assistance and Andrea Ferrero for laboratory
management. We thank Robert Webster for providing virus strains used in
this study. We thank Drs. James Stevens and Ruben Donis with the glycan
array work and for carefully editing the manuscript. Glycan microarray
data presented here will be made available online through the Consortium
for Functional Glycomics website http://www.functionalglycomics.org. The
glycan microarray was produced for the Centers for Disease Control by
using a glycan library generously provided by the Consortium for
Functional Glycomics funded by National Institute of General Medical
Sciences Grant GM62116. This research was possible through funding by
the CDC-HHS grant (1U01CI000355), NIAID-NIH grant, (R01AI052155),
CSREES-USDA grant (2005-05523), and NIAID-NIH contract,
(HHSN266200700010C). The opinions in this manuscript are those of the
authors and do not necessarily represent the views of the granting
agencies.
NR 38
TC 16
Z9 16
U1 1
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD AUG 14
PY 2009
VL 6
AR 126
DI 10.1186/1743-422X-6-126
PG 12
WC Virology
SC Virology
GA 499GG
UT WOS:000270205400001
PM 19682381
ER
PT J
AU Faix, DJ
Sherman, SS
Waterman, SH
AF Faix, Dennis J.
Sherman, Sterling S.
Waterman, Steven H.
TI Rapid-Test Sensitivity for Novel Swine-Origin Influenza A (H1N1) Virus
in Humans
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
C1 [Faix, Dennis J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA.
[Sherman, Sterling S.] USN, Med Ctr, San Diego, CA 92152 USA.
[Waterman, Steven H.] Ctr Dis Control & Prevent, San Diego, CA USA.
RP Faix, DJ (reprint author), USN, Hlth Res Ctr, San Diego, CA 92152 USA.
EM dennis.faix@med.navy.mil
RI Valle, Ruben/A-7512-2013
NR 4
TC 186
Z9 191
U1 0
U2 8
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD AUG 13
PY 2009
VL 361
IS 7
BP 728
EP 729
DI 10.1056/NEJMc0904264
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 482JX
UT WOS:000268884100030
PM 19564634
ER
PT J
AU Lucero, CA
Hageman, J
Zell, ER
Bulens, S
Nadle, J
Petit, S
Gershman, K
Ray, S
Harrison, LH
Lynfield, R
Dumyati, G
Townes, JM
Schaffner, W
Fridkin, SK
AF Lucero, Cynthia A.
Hageman, Jeffrey
Zell, Elizabeth R.
Bulens, Sandra
Nadle, Joelle
Petit, Susan
Gershman, Ken
Ray, Susan
Harrison, Lee H.
Lynfield, Ruth
Dumyati, Ghinwa
Townes, John M.
Schaffner, William
Fridkin, Scott K.
CA ABCs MRSA Investigators
TI Evaluating the potential public health impact of a Staphylococcus aureus
vaccine through use of population-based surveillance for invasive
methicillin-resistant S. aureus disease in the United States
SO VACCINE
LA English
DT Article
DE Staphylococcal vaccines; Methicillin-resistant Staphylococcus aureus;
Potential benefits
ID CARE SAFETY NETWORK; PNEUMOCOCCAL VACCINATION; CONJUGATE VACCINE; AGED
65; INFLUENZA; INFECTIONS; COVERAGE; PREVENTION
AB We evaluated the potential effects of a hypothetical vaccine in preventing invasive methicillin-resistant Staphylococcus aureus (MRSA) disease in the United States. Using an active, population-based surveillance program, we estimated baseline disease rates in the United States and compared three distinct vaccination strategies which targeted adults >= 65 years of age, persons at risk for recurrent invasive infection, and patients at hospital discharge. The strategies were projected to reduce the burden of invasive MRSA disease by 12.1%,13.9% and 17.6%, respectively; with the strategy of vaccinating both adults >= 65 years of age and all adults at hospital discharge having the greatest impact per dose. Our data suggest that availability of an effective S. aureus vaccine could result in substantial reductions in invasive MRSA disease incidence. As candidate vaccines are evaluated, these data will be important in determining the optimal vaccination strategy. Published by Elsevier Ltd.
C1 [Lucero, Cynthia A.; Hageman, Jeffrey; Bulens, Sandra; Fridkin, Scott K.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA.
[Lucero, Cynthia A.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA.
[Zell, Elizabeth R.] Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Coordinating Ctr Infect Dis, Atlanta, GA 30333 USA.
[Bulens, Sandra] AREF, Decatur, GA 30033 USA.
[Nadle, Joelle] Calif Emerging Infect Program, Oakland, CA 94612 USA.
[Petit, Susan] Connecticut Dept Hlth, Hartford, CT 06134 USA.
[Gershman, Ken] DCEED DSI A3, Colorado Emerging Infect Program, Denver, CO 80246 USA.
[Ray, Susan] Georgia Emerging Infect Program, Atlanta, GA 30303 USA.
[Harrison, Lee H.] Maryland Emerging Infect Program, Baltimore, MD 21205 USA.
[Harrison, Lee H.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA.
[Lynfield, Ruth] Minnesota Dept Hlth, Minneapolis, MN 55164 USA.
[Dumyati, Ghinwa] Univ Rochester, Rochester Gen Hosp, Rochester, NY 14621 USA.
[Townes, John M.] Oregon Hlth & Sci Univ, Portland, OR 97239 USA.
[Schaffner, William] Vanderbilt Univ, Sch Med, Nashville, TN 37243 USA.
[Schaffner, William] Tennessee Dept Hlth, Nashville, TN 37243 USA.
RP Fridkin, SK (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Preparedness Detect & Control Infect Dis, MS A-35,1600 Clifton Rd NE, Atlanta, GA 30333 USA.
EM SFridkin@CDC.gov
OI Shutt, Kathleen/0000-0003-3376-6152
NR 23
TC 14
Z9 14
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD AUG 13
PY 2009
VL 27
IS 37
BP 5061
EP 5068
DI 10.1016/j.vaccine.2009.06.055
PG 8
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 485ED
UT WOS:000269102800007
PM 19576943
ER
PT J
AU McElroy, AK
Albarino, CG
Nichol, ST
AF McElroy, Anita K.
Albarino, Cesar G.
Nichol, Stuart T.
TI Development of a RVFV ELISA that can distinguish infected from
vaccinated animals
SO VIROLOGY JOURNAL
LA English
DT Article
ID RIFT-VALLEY FEVER; VIRUS-VACCINE; IGM ANTIBODIES; NSS PROTEIN;
N-PROTEIN; IMMUNOGENICITY; HUMANS; CATTLE; SHEEP; EXPRESSION
AB Background: Rift Valley Fever Virus is a pathogen of humans and livestock that causes significant morbidity and mortality throughout Africa and the Middle East. A vaccine that would protect animals from disease would be very beneficial to the human population because prevention of the amplification cycle in livestock would greatly reduce the risk of human infection by preventing livestock epizootics. A mutant virus, constructed through the use of reverse genetics, is protective in laboratory animal models and thus shows promise as a potential vaccine. However, the ability to distinguish infected from vaccinated animals is important for vaccine acceptance by national and international authorities, given regulations restricting movement and export of infected animals.
Results: In this study, we describe the development of a simple assay that can be used to distinguish naturally infected animals from ones that have been vaccinated with a mutant virus. We describe the cloning, expression and purification of two viral proteins, and the development of side by side ELISAs using the two viral proteins.
Conclusion: A side by side ELISA can be used to differentiate infected from vaccinated animals. This assay can be done without the use of biocontainment facilities and has potential for use in both human and animal populations.
C1 [McElroy, Anita K.; Albarino, Cesar G.; Nichol, Stuart T.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Special Pathogens Branch, Atlanta, GA 30333 USA.
[McElroy, Anita K.] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA.
RP Nichol, ST (reprint author), Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Special Pathogens Branch, Atlanta, GA 30333 USA.
EM gsz5@cdc.gov; bwu4@cdc.gov; stn1@cdc.gov
NR 32
TC 28
Z9 28
U1 1
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T
4LB, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD AUG 13
PY 2009
VL 6
AR 125
DI 10.1186/1743-422X-6-125
PG 11
WC Virology
SC Virology
GA 488DN
UT WOS:000269329400001
PM 19678951
ER
PT J
AU Ahmed, K
Scholle, S
Baasiri, H
Hoover, KW
Kent, CK
Romaguera, R
Tao, G
AF Ahmed, K.
Scholle, S.
Baasiri, H.
Hoover, K. W.
Kent, C. K.
Romaguera, R.
Tao, G.
TI Chlamydia Screening Among Sexually Active Young Female Enrollees of
Health Plans-United States, 2000-2007 (Reprinted from MMWR, vol 58, pg
362-365, 2009)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
ID WOMEN; PREVALENCE; ADULTS
C1 [Ahmed, K.; Scholle, S.; Baasiri, H.] Natl Comm Qual Assurance, Washington, DC USA.
[Hoover, K. W.; Kent, C. K.; Romaguera, R.; Tao, G.] CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div STD Prevent, Atlanta, GA 30333 USA.
RP Ahmed, K (reprint author), Natl Comm Qual Assurance, Washington, DC USA.
NR 11
TC 0
Z9 0
U1 1
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD AUG 12
PY 2009
VL 302
IS 6
BP 620
EP 621
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 481ZI
UT WOS:000268852300010
ER
PT J
AU Ford, ES
Bergmann, MM
Kroger, J
Schienkiewitz, A
Weikert, C
Boeing, H
AF Ford, Earl S.
Bergmann, Manuela M.
Kroeger, Janine
Schienkiewitz, Anja
Weikert, Cornelia
Boeing, Heiner
TI Healthy Living Is the Best Revenge Findings From the European
Prospective Investigation Into Cancer and Nutrition-Potsdam Study
SO ARCHIVES OF INTERNAL MEDICINE
LA English
DT Article
ID CORONARY-HEART-DISEASE; LIFE-STYLE FACTORS; PRIMARY PREVENTION; WOMEN;
POPULATIONS; PROJECT; STROKE; DIET; MEN; QUESTIONNAIRE
AB Background: Our objective was to describe the reduction in relative risk of developing major chronic diseases such as cardiovascular disease, diabetes, and cancer associated with 4 healthy lifestyle factors among German adults.
Methods: We used data from 23 153 German participants aged 35 to 65 years from the European Prospective Investigation Into Cancer and Nutrition-Potsdam study. End points included confirmed incident type 2 diabetes mellitus, myocardial infarction, stroke, and cancer. The 4 factors were never smoking, having a body mass index lower than 30 (calculated as weight in kilograms divided by height in meters squared), performing 3.5 h/wk or more of physical activity, and adhering to healthy dietary principles (high intake of fruits, vegetables, and whole-grain bread and low meat consumption). The 4 factors (healthy, 1. point; unhealthy, 0 points) were summed to form an index that ranged from 0 to 4.
Results: During a mean follow-up of 7.8 years, 2006 participants developed new-onset diabetes (3.7%), myocardial infarction (0.9%), stroke (0.8%), or cancer (3.8%). Fewer than 4% of participants had zero healthy factors, most had 1. to 3 healthy factors, and approximately 9% had 4 factors. After adjusting for age, sex, educational status, and occupational status, the hazard ratio for developing a chronic disease decreased progressively as the number of healthy factors increased. Participants with all 4 factors at baseline had a 78% (95% confidence interval [CI], 72% to 83%) lower risk of developing a chronic disease (diabetes, 93% [95% CI, 88% to 95%]; myocardial infarction, 81% [95% CI, 47% to 93%]; stroke, 50% [95% CI, -18% to 79%]; and cancer, 36% [95% CI, 5% to 57%]) than participants without a healthy factor.
Conclusion: Adhering to 4 simple healthy lifestyle factors can have a strong impact on the prevention of chronic diseases.
C1 [Ford, Earl S.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Bergmann, Manuela M.; Kroeger, Janine; Schienkiewitz, Anja; Weikert, Cornelia; Boeing, Heiner] Deutsch Inst Ernahrungsforsch, German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany.
RP Ford, ES (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,Mail Stop K-66, Atlanta, GA 30341 USA.
EM eford@cdc.gov
FU Federal Ministry of Science, Germany [01 EA 9401]; European Union [SOC
95201408 05F02]; German Cancer Aid [70-2488-Ha I]; European Community
[SOC 98200769 05F02]; German Research Foundation (Deutsche
Forschungsgemeinschaft) [KFO 114]
FX Funding/Support: The recruitment phase of the EPIC-Potsdam study was
supported by the Federal Ministry of Science, Germany (contract 01 EA
9401) and the European Union (grant SOC 95201408 05F02). The follow-up
of the EPIC-Potsdam study was supported by the German Cancer Aid (grant
70-2488-Ha I) and the European Community (grant SOC 98200769 05F02). The
study was also supported by a grant from the German Research Foundation
(Deutsche Forschungsgemeinschaft, KFO 114).
NR 27
TC 157
Z9 161
U1 2
U2 24
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-9926
EI 1538-3679
J9 ARCH INTERN MED
JI Arch. Intern. Med.
PD AUG 10
PY 2009
VL 169
IS 15
BP 1355
EP 1362
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA 481HJ
UT WOS:000268798100003
PM 19667296
ER
PT J
AU Jones, DS
Tshimanga, M
Woelk, G
Nsubuga, P
Sunderland, NL
Hader, SL
St Louis, ME
AF Jones, Donna S.
Tshimanga, Mufuta
Woelk, Godfrey
Nsubuga, Peter
Sunderland, Nadine L.
Hader, Shannon L.
St Louis, Michael E.
TI Increasing leadership capacity for HIV/AIDS programmes by strengthening
public health epidemiology and management training in Zimbabwe
SO HUMAN RESOURCES FOR HEALTH
LA English
DT Article
ID MILLENNIUM DEVELOPMENT GOALS; FIELD EPIDEMIOLOGY; HUMAN-RESOURCES;
GLOBAL HEALTH; CRISIS; EDUCATION
AB Background: Increased funding for global human immunodeficiency virus prevention and control in developing countries has created both a challenge and an opportunity for achieving long-term global health goals. This paper describes a programme in Zimbabwe aimed at responding more effectively to the HIV/AIDS epidemic by reinforcing a critical competence-based training institution and producing public health leaders.
Methods: The programme used new HIV/AIDS programme-specific funds to build on the assets of a local education institution to strengthen and expand the general public health leadership capacity in Zimbabwe, simultaneously ensuring that they were trained in HIV interventions.
Results: The programme increased both numbers of graduates and retention of faculty. The expanded HIV/AIDS curriculum was associated with a substantial increase in trainee projects related to HIV. The increased number of public health professionals has led to a number of practically trained persons working in public health leadership positions in the ministry, including in HIV/AIDS programmes.
Conclusion: Investment of a modest proportion of new HIV/AIDS resources in targeted public health leadership training programmes can assist in building capacity to lead and manage national HIV and other public health programmes.
C1 [Jones, Donna S.; Nsubuga, Peter] Ctr Dis Control & Prevent, Div Global Publ Hlth Capac Dev, Atlanta, GA 30333 USA.
[Tshimanga, Mufuta] Univ Zimbabwe, Fac Med, Dept Community Med, MPH Programme, Harare, Zimbabwe.
[Woelk, Godfrey] RTI Int, Res Triangle Pk, NC USA.
[Sunderland, Nadine L.] Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA USA.
[Hader, Shannon L.] DC Dept Hlth, HIV AIDS Adm, Washington, DC USA.
[St Louis, Michael E.] Ctr Dis Control & Prevent, Coordinating Off Global Hlth, Atlanta, GA USA.
RP Jones, DS (reprint author), Ctr Dis Control & Prevent, Div Global Publ Hlth Capac Dev, Atlanta, GA 30333 USA.
EM doj3@cdc.gov; tshimang@ecoweb.co.zw; gwoelk@rti.org; pcn0@cdc.gov;
nis9@cdc.gov; Shannon.hader@dc.gov; mes2@cdc.gov
NR 34
TC 5
Z9 5
U1 10
U2 15
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1478-4491
J9 HUM RESOUR HEALTH
JI Hum. Resour. Health
PD AUG 10
PY 2009
VL 7
AR 69
DI 10.1186/1478-4491-7-69
PG 8
WC Health Policy & Services; Industrial Relations & Labor
SC Health Care Sciences & Services; Business & Economics
GA 494CH
UT WOS:000269786500001
PM 19664268
ER
PT J
AU Gysels, M
Pell, C
Mathanga, DP
Adongo, P
Odhiambo, F
Gosling, R
Akweongo, P
Mwangi, R
Okello, G
Mangesho, P
Slutsker, L
Kremsner, PG
Grobusch, MP
Hamel, MJ
Newman, RD
Pool, R
AF Gysels, Marjolein
Pell, Christopher
Mathanga, Don P.
Adongo, Philip
Odhiambo, Frank
Gosling, Roly
Akweongo, Patricia
Mwangi, Rose
Okello, George
Mangesho, Peter
Slutsker, Lawrence
Kremsner, Peter G.
Grobusch, Martin P.
Hamel, Mary J.
Newman, Robert D.
Pool, Robert
TI Community response to intermittent preventive treatment of malaria in
infants (IPTi) delivered through the expanded programme of immunization
in five African settings
SO MALARIA JOURNAL
LA English
DT Article
ID PLACEBO-CONTROLLED TRIAL; ROUTINE VACCINATIONS; SOUTHERN TANZANIA;
DOUBLE-BLIND; HEALTH; GHANA; TIME
AB Background: IPTi delivered through EPI has been shown to reduce the incidence of clinical malaria by 20-59%. However, new health interventions can only be effective if they are also socially and culturally acceptable. It is also crucial to ensure that attitudes to IPTi do not negatively influence attitudes to and uptake of immunization, or that people do not misunderstand IPTi as immunization against malaria and neglect other preventive measures or delay treatment seeking.
Methods: These issues were studied in five African countries in the context of clinical trials and implementation studies of IPTi. Mixed methods were used, including structured questionnaires (1,296), semi-structured interviews (168), in-depth interviews (748) and focus group discussions (95) with mothers, fathers, health workers, community members, opinion leaders, and traditional healers. Participant observation was also carried out in the clinics.
Results: IPTi was widely acceptable because it resonated with existing traditional preventive practices and a general concern about infant health and good motherhood. It also fit neatly within already widely accepted routine vaccination. Acceptance and adherence were further facilitated by the hierarchical relationship between health staff and mothers and by the fact that clinic attendance had a social function for women beyond acquiring health care. Type of drug and regimen were important, with newer drugs being seen as more effective, but potentially also more dangerous. Single dose infant formulations delivered in the clinic seem to be the most likely to be both acceptable and adhered to. There was little evidence that IPTi per se had a negative impact on attitudes to EPI or that it had any affect on EPI adherence. There was also little evidence of IPTi having a negative impact on health seeking for infants with febrile illness or existing preventive practices.
Conclusion: IPTi is generally acceptable across a wide range of settings in Africa and involving different drugs and regimens, though there is a strong preference for a single dose infant formulation. IPTi does not appear to have any negative effect on attitudes to EPI, and it is not interpreted as immunization against malaria.
C1 [Gysels, Marjolein; Pell, Christopher; Pool, Robert] Univ Barcelona, Ctr Int Hlth Res CRESIB, E-08007 Barcelona, Spain.
[Mathanga, Don P.] Coll Med, Malaria Alert Ctr, Blantyre, Malawi.
[Adongo, Philip; Akweongo, Patricia] Navrongo Hlth Res Ctr, Navrongo, Ghana.
[Odhiambo, Frank; Okello, George; Hamel, Mary J.] Kenya Govt Med Res Ctr, Kisumu, Kenya.
[Gosling, Roly; Pool, Robert] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England.
[Mwangi, Rose] Kilimanjaro Christian Med Ctr, Joint Malaria Program, Moshi, Tanzania.
[Mangesho, Peter] Amani Res Ctr, Natl Inst Med Res, Muheza, Tanzania.
[Slutsker, Lawrence; Hamel, Mary J.; Newman, Robert D.] Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA USA.
[Kremsner, Peter G.; Grobusch, Martin P.] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon.
[Kremsner, Peter G.] Univ Tubingen, Inst Trop Med, Tubingen, Germany.
[Grobusch, Martin P.] Univ Witwatersrand, Natl Hlth Lab Serv, Div Clin Microbiol & Infect Dis, Infect Dis Unit, Johannesburg, South Africa.
[Grobusch, Martin P.] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa.
RP Pool, R (reprint author), Univ Barcelona, Ctr Int Hlth Res CRESIB, E-08007 Barcelona, Spain.
EM marjolein.gysels@cresib.cat; christopher.pell@cresib.cat;
dmathanga@yahoo.com; adongophilip@yahoo.com; fodhiambo@ke.cdc.gov;
Roly.Gosling@lshtm.ac.uk; akweongo@gmail.com;
mwangirose2000@yahoo.co.uk; gokello@nairobi.kemri-wellcome.org;
mangeshop@yahoo.com; lms5@cdc.gov; peter.kremsner@uni-tuebingen.de;
Martin.Grobusch@wits.ac.za; mhamel@ke.cdc.gov; ren5@cdc.gov;
robert.pool@cresib.cat
OI Pell, Christopher/0000-0001-9405-5851
FU Bill and Melinda Gates Foundation through the IPTi Consortium
FX The authors would like to thank the mothers, health workers and other
community members who gave up their time to participate in these
studies. The authors would also like to express their gratitude to
Andrea Egan and Brian Greenwood for their useful comments. The project
was funded by a grant from the Bill and Melinda Gates Foundation through
the IPTi Consortium. Views expressed here are not necessarily those of
the Centers for Disease Control and Prevention or the US Department of
Health and Human Services.
NR 21
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U1 1
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD AUG 10
PY 2009
VL 8
AR 191
DI 10.1186/1475-2875-8-191
PG 16
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 495EW
UT WOS:000269874400001
PM 19664250
ER
PT J
AU Jamieson, DJ
Honein, MA
Rasmussen, SA
Williams, JL
Swerdlow, DL
Biggerstaff, MS
Lindstrom, S
Louie, JK
Christ, CM
Bohm, SR
Fonseca, VP
Ritger, KA
Kuhles, DJ
Eggers, P
Bruce, H
Davidson, HA
Lutterloh, E
Harris, ML
Burke, C
Cocoros, N
Finelli, L
MacFarlane, KF
Shu, B
Olsen, SJ
AF Jamieson, Denise J.
Honein, Margaret A.
Rasmussen, Sonja A.
Williams, Jennifer L.
Swerdlow, David L.
Biggerstaff, Matthew S.
Lindstrom, Stephen
Louie, Janice K.
Christ, Cara M.
Bohm, Susan R.
Fonseca, Vincent P.
Ritger, Kathleen A.
Kuhles, Danel J.
Eggers, Paula
Bruce, Hollianne
Davidson, Heidi A.
Lutterloh, Emily
Harris, Meghan L.
Burke, Colleen
Cocoros, Noelle
Finelli, Lyn
MacFarlane, Kitty F.
Shu, Bo
Olsen, Sonja J.
CA Novel Influenza A H1N1 Pregnancy W
TI H1N1 2009 influenza virus infection during pregnancy in the USA
SO LANCET
LA English
DT Article
ID MATERNAL INFLUENZA; ASIAN INFLUENZA; A H1N1; PANDEMIC INFLUENZA; H5N1
INFECTION; APRIL-MAY; WOMEN; INFANTS; IMPACT; SAFETY
AB Background Pandemic HlN1 2009 influenza virus has been identified as the cause of a widespread outbreak of febrile respiratory infection in the USA and worldwide. We summarised cases of infection with pandemic H1N1 virus in pregnant women identified in the USA during the first month of the present outbreak, and deaths associated with this virus during the first 2 months of the outbreak.
Methods After initial reports of infection in pregnant women, the US Centers for Disease Control and Prevention (CDC) began systematically collecting additional information about cases and deaths in pregnant women in the USA with pandemic H1N1 virus infection as part of enhanced surveillance. A confirmed case was defined as an acute respiratory illness with laboratory-confirmed pandemic H1N1 virus infection by real-time reverse-transcriptase PCR or viral culture; a probable case was defined as a person with an acute febrile respiratory illness who was positive for influenza A, but negative for H1 and H3. We used population estimates derived from the 2007 census data to calculate rates of admission to hospital and illness.
Findings From April 15 to May 18, 2009, 34 confirmed or probable cases of pandemic H1N1 in pregnant women were reported to CDC from 13 states. 11 (32%) women were admitted to hospital. The estimated rate of admission for pandemic H1N1 influenza virus infection in pregnant women during the first month of the outbreak was higher than it was in the general population (0.32 per 100000 pregnant women, 95% CI 0.13-0.52 vs 0.076 per 100 000 population at risk, 95% CI 0.07-0.09). Between April 15 and June 16, 2009, six deaths in pregnant women were reported to the CDC; all were in women who had developed pneumonia and subsequent acute respiratory distress syndrome requiring mechanical ventilation.
Interpretation Pregnant women might be at increased risk for complications from pandemic H1N1 virus infection. These data lend support to the present recommendation to promptly treat pregnant women with H1N1 influenza virus infection with anti-influenza drugs.
Funding US CDC.
C1 [Jamieson, Denise J.] CDC, Div Reprod Hlth, NCCDPHP, Atlanta, GA 30341 USA.
[Honein, Margaret A.; Rasmussen, Sonja A.; Williams, Jennifer L.] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30341 USA.
[Swerdlow, David L.; Biggerstaff, Matthew S.; Lindstrom, Stephen; Finelli, Lyn; Shu, Bo; Olsen, Sonja J.] CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30341 USA.
[Lutterloh, Emily] CDC, EIS Program, Off Workforce & Career Dev, Atlanta, GA 30341 USA.
[Louie, Janice K.] Calif Dept Publ Hlth, Richmond, CA USA.
[Christ, Cara M.] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA.
[Bohm, Susan R.] Michigan Dept Community Hlth, Lansing, MI USA.
[Fonseca, Vincent P.] Texas Dept State Hlth Serv, Austin, TX USA.
[Ritger, Kathleen A.] Chicago Dept Publ Hlth, Chicago, IL USA.
[Kuhles, Danel J.] Nassau Cty Dept Hlth, Uniondale, NY USA.
[Eggers, Paula] Delaware Div Publ Hlth, Dover, DE USA.
[Bruce, Hollianne] Snohomish Hlth Dist, Everett, WA USA.
[Davidson, Heidi A.] DeKalb Cty Board Hlth, Atlanta, GA USA.
[Lutterloh, Emily] Kentucky Dept Publ Hlth, Frankfort, KY USA.
[Harris, Meghan L.] Iowa Dept Publ Hlth, Des Moines, IA 50319 USA.
[Burke, Colleen] Philadelphia Dept Publ Hlth, Philadelphia, PA USA.
[Cocoros, Noelle] Massachusetts Dept Publ Hlth, Jamaica Plain, MA USA.
RP Jamieson, DJ (reprint author), CDC, Div Reprod Hlth, NCCDPHP, Mail Stop K-34,4770 Buford Hwy NE, Atlanta, GA 30341 USA.
EM DJamieson@cdc.gov
FU US CDC
FX The US CDC provided funding for this study. The findings and conclusions
in this report are those of the authors and do not necessarily represent
the official position of the Centers for Disease Control and Prevention.
NR 40
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U1 3
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
J9 LANCET
JI Lancet
PD AUG 8
PY 2009
VL 374
IS 9688
BP 451
EP 458
DI 10.1016/S0140-6736(09)61304-0
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA 482OK
UT WOS:000268898400026
PM 19643469
ER
PT J
AU Jackson, LA
Yu, O
Nelson, J
Belongia, EA
Hambidge, SJ
Baxter, R
Naleway, A
Nordin, J
Baggs, J
Iskander, J
AF Jackson, Lisa A.
Yu, Onchee
Nelson, Jennifer
Belongia, Edward A.
Hambidge, Simon J.
Baxter, Roger
Naleway, Allison
Nordin, James
Baggs, James
Iskander, John
TI Risk of medically attended local reactions following diphtheria toxoid
containing vaccines in adolescents and young adults: A Vaccine Safety
Datalink study
SO VACCINE
LA English
DT Article
DE Vaccine safety; Tetanus vaccine; Pertussis vaccine
ID ACELLULAR PERTUSSIS-VACCINE; IMMUNIZATION PRACTICES ACIP;
ADVISORY-COMMITTEE; PREVENTING TETANUS; RECOMMENDATIONS
AB Three vaccines currently recommended for adolescents (Tdap, Td, and MCV4 meningococcal conjugate vaccine) contain diphtheria toxoid. While the safety of individual diphtheria toxoid containing vaccines has been evaluated, less is known regarding the safety of administration of two or more of these vaccines, either concomitantly or sequentially. This study evaluated the risk of medically attended local reactions in adolescents and young adults with varying patterns of receipt of diphtheria toxoid containing vaccines. In general the risk of medically attended local reactions was low and did not differ with concomitant or sequential administration of diphtheria toxoid containing vaccines. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Jackson, Lisa A.; Yu, Onchee; Nelson, Jennifer] Grp Hlth Ctr Hlth Studies, Seattle, WA 98101 USA.
[Belongia, Edward A.] Marshfield Clin Res Fdn, Epidemiol Res Ctr, Marshfield, WI USA.
[Hambidge, Simon J.] Kaiser Permanente Inst Hlth Res, Denver, CO USA.
[Hambidge, Simon J.] Denver Hlth Community Hlth Serv, Denver, CO USA.
[Nelson, Jennifer] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
[Baxter, Roger] Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA.
[Naleway, Allison] Kaiser Permanente NW, Portland, OR USA.
[Nordin, James] HealthPartners, Minneapolis, MN USA.
[Baggs, James; Iskander, John] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Jackson, LA (reprint author), Grp Hlth Ctr Hlth Studies, 7730 Minor Ave,Ste 1600, Seattle, WA 98101 USA.
EM Jackson.L@ghc.org
OI Naleway, Allison/0000-0001-5747-4643; Baggs, James/0000-0003-0757-4683
FU Centers for Disease Control and Prevention (CDC) [200-2002-00732]
FX This study was funded through a subcontract with America's Health
Insurance Plans (AHIP) under contract 200-2002-00732 from the Centers
for Disease Control and Prevention (CDC).
NR 14
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U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD AUG 6
PY 2009
VL 27
IS 36
BP 4912
EP 4916
DI 10.1016/j.vaccine.2009.06.038
PG 5
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 484UA
UT WOS:000269071800007
PM 19567245
ER
PT J
AU Zhao, Z
Smith, PJ
Luman, ET
AF Zhao, Zhen
Smith, Philip J.
Luman, Elizabeth T.
TI Trends in early childhood vaccination coverage: Progress towards US
Healthy People 2010 goals
SO VACCINE
LA English
DT Article
DE Healthy People 2010; Childhood immunization; Vaccination; Trends;
Prediction
ID NATIONAL-IMMUNIZATION-SURVEY; UNITED-STATES; DISPARITIES; TIMELINESS;
SHORTAGES; CHILDREN; DTAP
AB Objectives: To evaluate trends in national vaccination coverage from 2000 to 2007 among children aged 19-35 months for at least four doses of diphtheria-tetanus-pertussis vaccine (4 + DTaP), three doses of poliovirus vaccine (3 + Polio), one dose of measles-mumps-rubella vaccine (1 + MMR), three doses of Haemophilus influenzae type b vaccine (3 + Hib), three doses of hepatitis B vaccine (3 + HepB), one dose of Varicella vaccine (1 + Var), and the standard vaccine series of these six vaccines (4:3:1:1:3:3:1). To predict vaccination coverage levels in 2008-2010 for those vaccines that have not yet reached the Healthy People 2010 coverage targets of 90% for individual vaccines and 80% for the vaccine series.
Methods: Data were analyzed for 167,086 children aged 19-35 months in the 2000-2007 National Immunization Survey. Vaccination coverage trends were analyzed with weighted least squares linear regression models. Nonlinear Weibull and logarithmic regression models were fitted to these past results, and extrapolation was used to predict vaccination coverage levels for 4 + DTaP, 1 + Var, and the 4:3:1:3:3:1 series from 2008 to 2010.
Results: From 2000 to 2007, observed vaccination coverage increased significantly for four of the six vaccines and the standard vaccine series, and reached the 90% target for 3 + Polio, 1 + MMR, 3 + Hib, and 3 + HepB. Increases in coverage were not significant for 1 + MMR and 3 + Hib; however, coverage for these vaccines was consistently> 90% throughout the study period. Both Weibull and logarithmic regression models predicted that coverage with 1 +Var and the 4:1:1:3:3:1 series will surpass the 2010 target by 2008, while coverage with 4 + DTaP will fall short of the target at 86% in 2010.
Conclusions: The United States is well on the way toward reaching most of the Healthy People 2010 objectives for early childhood vaccination coverage. Enhanced efforts are needed to ensure that these trends continue, and to increase coverage with 4 + DTaP. Published by Elsevier Ltd.
C1 [Zhao, Zhen; Smith, Philip J.; Luman, Elizabeth T.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Med, Atlanta, GA 30333 USA.
RP Zhao, Z (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Med, 1600 Clifton Rd NE,MS E62, Atlanta, GA 30333 USA.
EM zaz0@cdc.gov
FU National Immunization Survey; Centers for Disease Control and
Prevention; US Department of Health and Human Services
FX Funding/support: This research and the National Immunization Survey were
conducted through funding and approval by the Centers for Disease
Control and Prevention, US Department of Health and Human Services.
NR 28
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U1 1
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD AUG 6
PY 2009
VL 27
IS 36
BP 5008
EP 5012
DI 10.1016/j.vaccine.2009.05.074
PG 5
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 484UA
UT WOS:000269071800020
PM 19524616
ER
PT J
AU Bilukha, O
Talley, L
Howard, C
AF Bilukha, O.
Talley, L.
Howard, C.
TI Impact of New WHO Growth Standards on the Prevalence of Acute
Malnutrition and Operations of Feeding Programs-Darfur, Sudan, 2005-2007
(Reprinted from MMWR, vol 58, pg 591-594, 2009)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Howard, C.] CDC, Atlanta, GA 30333 USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD AUG 5
PY 2009
VL 302
IS 5
BP 484
EP 485
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 479DS
UT WOS:000268640500005
ER
PT J
AU Brackbill, RM
Hadler, JL
DiGrande, L
Ekenga, CC
Farfel, MR
Friedman, S
Perlman, SE
Stellman, SD
Walker, DJ
Wu, D
Yu, SC
Thorpe, LE
AF Brackbill, Robert M.
Hadler, James L.
DiGrande, Laura
Ekenga, Christine C.
Farfel, Mark R.
Friedman, Stephen
Perlman, Sharon E.
Stellman, Steven D.
Walker, Deborah J.
Wu, David
Yu, Shengchao
Thorpe, Lorna E.
TI Asthma and Posttraumatic Stress Symptoms 5 to 6 Years Following Exposure
to the World Trade Center Terrorist Attack
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID NEW-YORK-CITY; CENTER HEALTH REGISTRY; DISASTER VICTIMS SPEAK; 11
SEPTEMBER 2001; PSYCHOMETRIC PROPERTIES; RESPIRATORY SYMPTOMS; RECOVERY
WORKERS; PTSD CHECKLIST; RISK-FACTORS; CENTER SITE
AB Context The World Trade Center Health Registry provides a unique opportunity to examine long-term health effects of a large-scale disaster.
Objective To examine risk factors for new asthma diagnoses and event-related post-traumatic stress (PTS) symptoms among exposed adults 5 to 6 years following exposure to the September 11, 2001, World Trade Center (WTC) terrorist attack.
Design, Setting, and Participants Longitudinal cohort study with wave 1 (W1) enrollment of 71 437 adults in 2003-2004, including rescue/recovery worker, lower Manhattan resident, lower Manhattan office worker, and passersby eligibility groups; 46 322 adults (68%) completed the wave 2 (W2) survey in 2006-2007.
Main Outcome Measures Self-reported diagnosed asthma following September 11; event-related current PTS symptoms indicative of probable posttraumatic stress disorder (PTSD), assessed using the PTSD Checklist (cutoff score >= 44).
Results Of W2 participants with no stated asthma history, 10.2% (95% confidence interval [CI], 9.9%-10.5%) reported new asthma diagnoses postevent. Intense dust cloud exposure on September 11 was a major contributor to new asthma diagnoses for all eligibility groups: for example, 19.1% vs 9.6% in those without exposure among rescue/recovery workers (adjusted odds ratio, 1.5 [ 95% CI, 1.4-1.7]). Asthma risk was highest among rescue/recovery workers on the WTC pile on September 11 (20.5% [ 95% CI, 19.0%-22.0%]). Persistent risks included working longer at the WTC site, not evacuating homes, and experiencing a heavy layer of dust in home or office. Of participants with no PTSD history, 23.8% ( 95% CI, 23.4%-24.2%) reported PTS symptoms at either W1(14.3%) or W2 (19.1%). Nearly 10% ( 9.6% [ 95% CI, 9.3%-9.8%]) had PTS symptoms at both surveys, 4.7% ( 95% CI, 4.5%-4.9%) had PTS symptoms at W1 only, and 9.5% ( 95% CI, 9.3%-9.8%) had PTS symptoms at W2 only. At W2, passersby had the highest rate of PTS symptoms (23.2% [ 95% CI, 21.4%-25.0%]). Event-related loss of spouse or job was associated with PTS symptoms at W2.
Conclusion Acute and prolonged exposures were both associated with a large burden of asthma and PTS symptoms 5 to 6 years after the September 11 WTC attack. JAMA. 2009;302(5):502-516 www.jama.com
C1 [Hadler, James L.; DiGrande, Laura; Ekenga, Christine C.; Farfel, Mark R.; Friedman, Stephen; Perlman, Sharon E.; Stellman, Steven D.; Walker, Deborah J.; Wu, David; Yu, Shengchao; Thorpe, Lorna E.] New York City Dept Hlth & Mental Hyg, New York, NY 10013 USA.
[Brackbill, Robert M.] Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, Atlanta, GA USA.
[Stellman, Steven D.] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA.
RP Thorpe, LE (reprint author), New York City Dept Hlth & Mental Hyg, 125 Worth St,Room 315, New York, NY 10013 USA.
EM lthorpe@health.nyc.gov
FU Agency for Toxic Substances and Disease Registry (ATSDR) of the Centers
for Disease Control and Prevention (CDC) [U50/ATU272750]; National
Center for Environmental Health (NCEH); New York City Department of
Health and Mental Hygiene (NYCDOHMH)
FX This study was supported by Cooperative Agreement U50/ATU272750 from the
Agency for Toxic Substances and Disease Registry (ATSDR) of the Centers
for Disease Control and Prevention (CDC), which included support from
the National Center for Environmental Health (NCEH), and by the New York
City Department of Health and Mental Hygiene (NYCDOHMH).
NR 52
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U1 2
U2 12
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD AUG 5
PY 2009
VL 302
IS 5
BP 502
EP 516
PG 15
WC Medicine, General & Internal
SC General & Internal Medicine
GA 479DS
UT WOS:000268640500015
PM 19654385
ER
PT J
AU Ghanem, MM
Battelli, LA
Law, BF
Castranova, V
Kashon, ML
Nath, J
Hubbs, AF
AF Ghanem, Mohamed M.
Battelli, Lori A.
Law, Brandon F.
Castranova, Vincent
Kashon, Michael L.
Nath, Joginder
Hubbs, Ann F.
TI Coal dust alters beta-naphthoflavone-induced aryl hydrocarbon receptor
nuclear translocation in alveolar type II cells
SO PARTICLE AND FIBRE TOXICOLOGY
LA English
DT Article
ID HUMAN LUNG-CANCER; AH RECEPTOR; CYTOCHROME P4501A1; RAT LUNG;
CRYSTALLINE SILICA; DIOXIN RECEPTOR; NITRIC-OXIDE; IN-VIVO; INDUCTION;
EXPRESSION
AB Background: Many polycyclic aromatic hydrocarbons (PAHs) can cause DNA adducts and initiate carcinogenesis. Mixed exposures to coal dust (CD) and PAHs are common in occupational settings. In the CD and PAH-exposed lung, CD increases apoptosis and causes alveolar type II (AT-II) cell hyperplasia but reduces CYP1A1 induction. Inflammation, but not apoptosis, appears etiologically associated with reduced CYP1A1 induction in this mixed exposure model. Many AT-II cells in the CD-exposed lungs have no detectable CYP1A1 induction after PAH exposure. Although AT-II cells are a small subfraction of lung cells, they are believed to be a potential progenitor cell for some lung cancers. Because CYP1A1 is induced via ligand-mediated nuclear translocation of the aryl hydrocarbon receptor (AhR), we investigated the effect of CD on PAH-induced nuclear translocation of AhR in AT-II cells isolated from in vivo-exposed rats. Rats received CD or vehicle (saline) by intratracheal (IT) instillation. Three days before sacrifice, half of the rats in each group started daily intraperitoneal injections of the PAH, beta-naphthoflavone (BNF).
Results: Fourteen days after IT CD exposure and 1 day after the last intraperitoneal BNF injection, AhR immunofluorescence indicated that proportional AhR nuclear expression and the percentage of cells with nuclear AhR were significantly increased in rats receiving IT saline and BNF injections compared to vehicle controls. However, in CD-exposed rats, BNF did not significantly alter the nuclear localization or cytosolic expression of AhR compared to rats receiving CD and oil.
Conclusion: Our findings suggest that during particle and PAH mixed exposures, CD alters the BNF-induced nuclear translocation of AhR in AT-II cells. This provides an explanation for the modification of CYP1A1 induction in these cells. Thus, this study suggests that mechanisms for reduced PAH-induced CYP1A1 activity in the CD exposed lung include not only the effects of inflammation on the lung as a whole, but also reduced PAH-associated nuclear translocation of AhR in an expanded population of AT-II cells.
C1 [Ghanem, Mohamed M.; Battelli, Lori A.; Nath, Joginder; Hubbs, Ann F.] W Virginia Univ, Genet & Dev Biol Program, Morgantown, WV 26506 USA.
[Ghanem, Mohamed M.; Battelli, Lori A.; Law, Brandon F.; Castranova, Vincent; Kashon, Michael L.; Hubbs, Ann F.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
[Ghanem, Mohamed M.] Benha Univ, Fac Vet Med Moshtohor, Dept Anim Med, Banha 13736, Egypt.
RP Hubbs, AF (reprint author), W Virginia Univ, Genet & Dev Biol Program, Morgantown, WV 26506 USA.
EM dr.mohamedghanem@yahoo.com; LBattelli@cdc.gov; BLaw@cdc.gov;
VCastranova@cdc.gov; MKashon@cdc.gov; jnath@wvu.edu; AHubbs@cdc.gov
FU National Institute for Occupational Safety and Health [39277263];
Advanced Research foundation; Egyptian Government (Benha University)
FX The authors gratefully acknowledge the assistance of Diane
Schwegler-Berry and Dr. Robert Mercer in the preparation and
interpretation of ATII cell electron microscopy. Appreciation is
extended to Dr. Rania Kanj for assistance in AT-II cell isolation and
Dr. Paul Siegel for expert assistance in analysis of PAHs in coal dust.
This research was supported by an intramural project (39277263) of the
National Institute for Occupational Safety and Health and was a part of
graduate research conducted by MMG. Data analysis and interpretation
were supported in part by a postgraduate research stipend from the
Advanced Research foundation and the Egyptian Government (Benha
University).
NR 54
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U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-8977
J9 PART FIBRE TOXICOL
JI Part. Fibre Toxicol.
PD AUG 3
PY 2009
VL 6
AR 21
DI 10.1186/1743-8977-6-21
PG 12
WC Toxicology
SC Toxicology
GA 497OI
UT WOS:000270068900001
PM 19650907
ER
PT J
AU Hess, JJ
Heilpern, KL
Davis, TE
Frumkin, H
AF Hess, Jeremy J.
Heilpern, Katherine L.
Davis, Timothy E.
Frumkin, Howard
TI Climate Change and Emergency Medicine: Impacts and Opportunities
SO ACADEMIC EMERGENCY MEDICINE
LA English
DT Review
DE emergency medicine; emergency services; hospital; emergency medical
services; disaster planning; climate; weather; greenhouse effect; health
policy
ID ATMOSPHERIC CARBON-DIOXIDE; VECTOR IXODES-SCAPULARIS; US NATIONAL
ASSESSMENT; TEXAS-MEXICO BORDER; 1995 HEAT-WAVE; UNITED-STATES; HUMAN
HEALTH; PUBLIC-HEALTH; HURRICANE-KATRINA; HOSPITAL ADMISSIONS
AB There is scientific consensus that the climate is changing, that human activity plays a major role, and that the changes will continue through this century. Expert consensus holds that significant health effects are very likely. Public health and health care systems must understand these impacts to properly pursue preparedness and prevention activities. All of medicine will very likely be affected, and certain medical specialties are likely to be more significantly burdened based on their clinical activity, ease of public access, public health roles, and energy use profiles. These specialties have been called on to consider the likely impacts on their patients and practice and to prepare their practitioners. Emergency medicine (EM), with its focus on urgent and emergent ambulatory care, role as a safety-net provider, urban concentration, and broad-based clinical mission, will very likely experience a significant rise in demand for its services over and above current annual increases. Clinically, EM will see amplification of weather-related disease patterns and shifts in disease distribution. In EM's prehospital care and disaster response activities, both emergency medical services (EMS) activity and disaster medical assistance team (DMAT) deployment activities will likely increase. EM's public health roles, including disaster preparedness, emergency department (ED)-based surveillance, and safety-net care, are likely to face increasing demands, along with pressures to improve fuel efficiency and reduce greenhouse gas emissions. Finally, EM's roles in ED and hospital management, particularly related to building and purchasing, are likely to be impacted by efforts to reduce greenhouse gas emissions and enhance energy efficiency. Climate change thus presents multiple clinical and public health challenges to EM, but also creates numerous opportunities for research, education, and leadership on an emerging health issue of global scope. ACADEMIC EMERGENCY MEDICINE 2009; 16: 782-794 (C) 2009 by the Society for Academic Emergency Medicine
C1 [Hess, Jeremy J.; Heilpern, Katherine L.; Davis, Timothy E.] Emory Univ, Sch Med, Dept Emergency Med, Atlanta, GA 30322 USA.
[Davis, Timothy E.] US PHS, HHS Off Assistant Secretary Preparedness & Respon, Washington, DC 20201 USA.
[Frumkin, Howard] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Frumkin, Howard] Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, Atlanta, GA USA.
RP Hess, JJ (reprint author), Emory Univ, Sch Med, Dept Emergency Med, Atlanta, GA 30322 USA.
EM jhess@emory.edu
OI Frumkin, Howard/0000-0001-7079-3534
NR 152
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U1 2
U2 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1069-6563
EI 1553-2712
J9 ACAD EMERG MED
JI Acad. Emerg. Med.
PD AUG
PY 2009
VL 16
IS 8
BP 782
EP 794
DI 10.1111/j.1553-2712.2009.00469.x
PG 13
WC Emergency Medicine
SC Emergency Medicine
GA 476QL
UT WOS:000268457300014
PM 19673715
ER
PT J
AU Haukoos, JS
Hopkins, E
Byyny, RL
Conroy, AA
Silverman, M
Eisert, S
Thrun, M
Wilson, M
Boyett, B
Heffelfinger, JD
AF Haukoos, Jason S.
Hopkins, Emily
Byyny, Richard L.
Conroy, Amy A.
Silverman, Morgan
Eisert, Sheri
Thrun, Mark
Wilson, Michael
Boyett, Brian
Heffelfinger, James D.
CA Denver ED HIV Opt-Out Study Grp
TI Design and Implementation of a Controlled Clinical Trial to Evaluate the
Effectiveness and Efficiency of Routine Opt-out Rapid Human
Immunodeficiency Virus Screening in the Emergency Department
SO ACADEMIC EMERGENCY MEDICINE
LA English
DT Article
DE HIV testing; emergency department; effectiveness; efficiency;
cost-effectiveness; acceptance; clinical trial; health services
research; program evaluation
ID SEXUALLY-TRANSMITTED-DISEASE; HEALTH-CARE SETTINGS; HIV-INFECTION;
UNITED-STATES; COST-EFFECTIVENESS; PREVALENCE AREA; PROGRAM;
RECOMMENDATIONS; PREVENTION; EXPERIENCE
AB In 2006, the Centers for Disease Control and Prevention (CDC) released revised recommendations for performing human immunodeficiency virus (HIV) testing in health care settings, including implementing routine rapid HIV screening, the use of an integrated opt-out consent, and limited prevention counseling. Emergency departments (EDs) have been a primary focus of these efforts. These revised CDC recommendations were primarily based on feasibility studies and have not been evaluated through the application of rigorous research methods. This article describes the design and implementation of a large prospective controlled clinical trial to evaluate the CDC's recommendations in an ED setting. From April 15, 2007, through April 15, 2009, a prospective quasi-experimental equivalent time-samples clinical trial was performed to compare the clinical effectiveness and efficiency of routine (nontargeted) opt-out rapid HIV screening (intervention) to physician-directed diagnostic rapid HIV testing (control) in a high-volume urban ED. In addition, three nested observational studies were performed to evaluate the cost-effectiveness and patient and staff acceptance of the two rapid HIV testing methods. This article describes the rationale, methodologies, and study design features of this program evaluation clinical trial. It also provides details regarding the integration of the principal clinical trial and its nested observational studies. Such ED-based trials are rare, but serve to provide valid comparisons between testing approaches. Investigators should consider similar methodology when performing future ED-based health services research. Academic Emergency Medicine 2009; 16: 800-808 (C) 2009 by the Society for Academic Emergency Medicine
C1 [Haukoos, Jason S.; Hopkins, Emily; Byyny, Richard L.] Denver Hlth Med Ctr, Dept Emergency Med, Denver, CO USA.
[Silverman, Morgan] Denver Hlth Med Ctr, Dept Clin Social Work, Denver, CO USA.
[Eisert, Sheri] Denver Hlth Med Ctr, Dept Hlth Serv Res, Denver, CO USA.
[Wilson, Michael] Denver Hlth Med Ctr, Dept Pathol, Denver, CO USA.
[Haukoos, Jason S.; Byyny, Richard L.; Thrun, Mark; Wilson, Michael] Univ Colorado, Denver Sch Med, Aurora, CO USA.
[Haukoos, Jason S.] Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA.
[Eisert, Sheri] Colorado Sch Publ Hlth, Dept Hlth Syst Management & Policy, Aurora, CO USA.
[Conroy, Amy A.] Univ Colorado Denver, Dept Hlth & Behav Sci, Denver, CO USA.
[Thrun, Mark] Denver Publ Hlth, Denver, CO USA.
[Boyett, Brian; Heffelfinger, James D.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA.
RP Haukoos, JS (reprint author), Denver Hlth Med Ctr, Dept Emergency Med, Denver, CO USA.
EM Jason.Haukoos@dhha.org
RI Siry, Bonnie/D-7189-2017
FU Centers for Disease Control and Prevention [U18 PS000314]; Agency for
Healthcare Research and Quality [K02 HS017526]; Colorado Center for AIDS
Research
FX This study is funded by a cooperative agreement (U18 PS000314) with the
Centers for Disease Control and Prevention (JSH) and supported, in part,
by an Independent Scientist Award (K02 HS017526) from the Agency for
Healthcare Research and Quality (JSH) and a Career Development Award
from the Colorado Center for AIDS Research (RLB).
NR 39
TC 13
Z9 13
U1 1
U2 4
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1069-6563
J9 ACAD EMERG MED
JI Acad. Emerg. Med.
PD AUG
PY 2009
VL 16
IS 8
BP 800
EP 808
DI 10.1111/j.1553-2712.2009.00477.x
PG 9
WC Emergency Medicine
SC Emergency Medicine
GA 476QL
UT WOS:000268457300016
PM 19673717
ER
PT J
AU Arnaud, J
Jones, RL
LeBlanc, A
Lee, MY
Mazarrasa, O
Parsons, P
Patriarca, M
Taylor, A
Weber, JP
Weykamp, C
AF Arnaud, Josiane
Jones, Robert L.
LeBlanc, Alain
Lee, Mi-Young
Mazarrasa, Olav
Parsons, Patrick
Patriarca, Marina
Taylor, Andrew
Weber, Jean-Philippe
Weykamp, Cas
TI Criteria to define the standard deviation for proficiency assessment for
the determination of essential trace elements in serum: comparison of
Z-scores based on the Horwitz function or on biological variability
SO ACCREDITATION AND QUALITY ASSURANCE
LA English
DT Article
CT 6th Workshop on Proficiency Testing in Analytical Chemistry,
Microbiology & Laboratory Medicine
CY OCT 06-07, 2008
CL Rome, ITALY
DE Quality specifications; Trace elements; Human serum; Human plasma;
Proficiency testing; Horwitz; Fraser
ID EVALUATING LABORATORY PERFORMANCE; QUALITY ASSESSMENT SCHEMES;
SPECIFICATIONS; SELENIUM; ZINC; COPPER; MG; CU
AB A critical issue in the organisation of Proficiency Testing/External Quality Assessment Schemes is the definition of the criteria against which the performance of individual laboratories should be evaluated. Organisers of EQAS in Occupational and Environmental Laboratory Medicine (http://www.occupational-environmental-laboratory.com) collaborate to define common acceptable levels of performance. The aim of this study was to compare the Horwitz function to the Fraser's approach. Sets of results obtained from the distribution of test materials in the Network schemes (for the measurands: copper, selenium or zinc in serum) were used to calculate Z-scores according to both approaches. Quality specifications derived from both approaches were also compared to the standard deviations obtained. Except for selenium, Horwitz criteria suggests a more stringent evaluation than Fraser criteria, the latter being very stringent as regard the participant analytical variability.
C1 [Arnaud, Josiane] CHU Grenoble, Dept Biol Integree, F-38043 Grenoble 9, France.
[Jones, Robert L.] Ctr Dis Control & Prevent, Elemental Anal Lab, Atlanta, GA 30341 USA.
[LeBlanc, Alain; Weber, Jean-Philippe] Inst Natl Sante Publ Quebec, Ctr Toxicol, Quebec City, PQ G1V 5B3, Canada.
[Lee, Mi-Young] Occupat Safety & Hlth Res Inst, Inchon 403711, South Korea.
[Mazarrasa, Olav] Gobierno Cantabria, Ctr Seguridad & Salud Trabajo, Santander 39012, Spain.
[Parsons, Patrick] New York State Dept Hlth, Wadsworth Ctr, Lab Inorgan & Nucl Chem, Albany, NY 12201 USA.
[Patriarca, Marina] Ist Super Sanita, Dept Publ Vet Hlth & Food Safety, I-00161 Rome, Italy.
[Taylor, Andrew] Univ Surrey, Fac Hlth & Med Sci, Ctr Clin Sci & Measurement, Guildford GU2 7XH, Surrey, England.
[Weykamp, Cas] Queen Beatrix Hosp, MCA Lab, NL-7101 BN Winterswijk, Netherlands.
RP Patriarca, M (reprint author), Ist Super Sanita, Dept Publ Vet Hlth & Food Safety, Viale Regina Elena 299, I-00161 Rome, Italy.
EM marina.patriarca@iss.it
RI PATRIARCA, MARINA/E-3680-2015;
OI Parsons, Patrick/0000-0001-9133-875X
NR 15
TC 5
Z9 5
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0949-1775
J9 ACCREDIT QUAL ASSUR
JI Accredit. Qual. Assur.
PD AUG
PY 2009
VL 14
IS 8-9
BP 427
EP 430
DI 10.1007/s00769-009-0561-4
PG 4
WC Chemistry, Analytical; Instruments & Instrumentation
SC Chemistry; Instruments & Instrumentation
GA 483FZ
UT WOS:000268949400004
ER
PT J
AU Taylor, A
Jones, RL
Leblanc, A
Mazarrasa, O
Lee, MY
Parsons, PJ
Patriarca, M
Weber, JP
Weykamp, C
AF Taylor, Andrew
Jones, Robert L.
Leblanc, Alain
Mazarrasa, Olav
Lee, Mi-Young
Parsons, Patrick J.
Patriarca, Marina
Weber, Jean-Philippe
Weykamp, Cas
TI Instability of mercury in specimens of human urine for external quality
assessment
SO ACCREDITATION AND QUALITY ASSURANCE
LA English
DT Article; Proceedings Paper
CT 6th Workshop on Proficiency Testing in Analytical Chemistry,
Microbiology and Laboratory Medicine
CY OCT 06-07, 2008
CL Rome, ITALY
DE Occupational and environmental laboratory medicine; External quality
assessment; Mercury in urine
AB An under-recovery of inorganic mercury added to urine and a wide range of results is observed in quality assessment schemes (EQAS) for trace elements. Furthermore, the under-recoveries are inconsistent suggesting features associated with the urine matrix may make the mercury unavailable for measurement. To investigate the instability of mercury in urine the following experiments were set up: (1) a sample of Hg2+ in water with various 'stabilizers' added was sent to UK external quality assessment scheme participants. (2) Urine was collected from volunteers who also completed a 3-day food diary. Hg, Ca, Mg, Se, uric acid, phosphate, creatinine, reducing substances and protein were measured. Inorganic mercury was spiked into the urine, stabilizers were added and the mercury determined following storage. The results confirmed under-recovery of mercury in association with the urine matrix. Further investigations of how urinary components affect the measurement of mercury are necessary.
C1 [Taylor, Andrew] Univ Surrey, Fac Hlth & Med Sci, Ctr Clin Sci & Measurement, Guildford GU2 7XH, Surrey, England.
[Jones, Robert L.] CDC, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Leblanc, Alain; Weber, Jean-Philippe] Inst Natl Sante Publ Quebec, Ctr Toxicol, Ste Foy, PQ G1V 5B3, Canada.
[Mazarrasa, Olav] Gobierno Cantabria, Lab Higiene Ind, Ctr Seguridad & Salud Trabajo, Santander 39012, Spain.
[Lee, Mi-Young] Occupat Safety & Hlth Res Inst, Inchon 403711, South Korea.
[Parsons, Patrick J.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA.
[Patriarca, Marina] Ist Super Sanita, Dept Vet Publ Hlth & Food Safety, I-00161 Rome, Italy.
[Weykamp, Cas] Queen Beatrix Hosp, MCA Lab, NL-7101 BN Winterswijk, Netherlands.
RP Taylor, A (reprint author), Univ Surrey, Fac Hlth & Med Sci, Ctr Clin Sci & Measurement, Guildford GU2 7XH, Surrey, England.
EM a.taylor@surrey.ac.uk
RI PATRIARCA, MARINA/E-3680-2015;
OI Parsons, Patrick/0000-0001-9133-875X
NR 10
TC 3
Z9 3
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0949-1775
J9 ACCREDIT QUAL ASSUR
JI Accredit. Qual. Assur.
PD AUG
PY 2009
VL 14
IS 8-9
BP 461
EP 466
DI 10.1007/s00769-009-0506-y
PG 6
WC Chemistry, Analytical; Instruments & Instrumentation
SC Chemistry; Instruments & Instrumentation
GA 483FZ
UT WOS:000268949400010
ER
PT J
AU Marks, G
Millett, GA
Bingham, T
Bond, L
Lauby, J
Liau, A
Murrill, CS
Stueve, A
AF Marks, Gary
Millett, Gregorio A.
Bingham, Trista
Bond, Lisa
Lauby, Jennifer
Liau, Adrian
Murrill, Christopher S.
Stueve, Ann
TI Understanding Differences in HIV Sexual Transmission among Latino and
Black Men who have Sex with Men: The Brothers y Hermanos Study
SO AIDS AND BEHAVIOR
LA English
DT Article
DE HIV/AIDS; Sexual transmission; MSM; Latino; Black; African American
ID UNPROTECTED ANAL INTERCOURSE; RISK BEHAVIORS; YOUNG MEN; BISEXUAL MEN;
WHITE MEN; INFECTION; INTERVENTION; METAANALYSIS; DISPARITIES;
PREVALENCE
AB HIV sexual transmission risk behaviors were examined among 1,065 Latino and 1,140 black men who have sex with men (MSM). Participants completed a computer-administered questionnaire and were tested for HIV infection. Of men who reported that their last HIV test was negative or that they had never been tested or did not get the result of their last test, 17% of black and 5% of Latino MSM tested HIV-positive in our study. In both ethnic groups, the three-month prevalence of unprotected anal intercourse (UAI) with HIV-negative or unknown serostatus partners was twice as high among men unaware of their HIV infection than men who knew they were HIV seropositive at the time of enrollment. UAI exclusively with HIV-positive partners was more prevalent among HIV-positive/aware than HIV-positive/unaware men. The findings advance understanding of the high incidence of HIV infection among black MSM in the U.S.
C1 [Marks, Gary; Millett, Gregorio A.; Liau, Adrian] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA.
[Bingham, Trista] Los Angeles Cty Dept Publ Hlth, HIV Epidemiol Program, Los Angeles, CA USA.
[Bond, Lisa; Lauby, Jennifer] Philadelphia Hlth Management Corp, Philadelphia, PA USA.
[Murrill, Christopher S.] New York City Dept Hlth & Mental Hyg, New York, NY USA.
[Stueve, Ann] Educ Dev Ctr, Newton, MA USA.
RP Marks, G (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd,MS E-45, Atlanta, GA 30333 USA.
EM gmarks@cdc.gov
NR 30
TC 39
Z9 39
U1 2
U2 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-7165
J9 AIDS BEHAV
JI AIDS behav.
PD AUG
PY 2009
VL 13
IS 4
BP 682
EP 690
DI 10.1007/s10461-008-9380-6
PG 9
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 476WS
UT WOS:000268478000009
PM 18752064
ER
PT J
AU O'Donnell, L
Bonaparte, B
Joseph, H
Agronick, G
Leow, DM
Myint-U, A
Stueve, A
AF O'Donnell, Lydia
Bonaparte, Beverly
Joseph, Heather
Agronick, Gail
Leow, Deborah McLean
Myint-U, Athi
Stueve, Ann
TI KEEP IT UP: DEVELOPMENT OF A COMMUNITY-BASED HEALTH SCREENING AND HIV
PREVENTION STRATEGY FOR REACHING YOUNG AFRICAN AMERICAN MEN
SO AIDS EDUCATION AND PREVENTION
LA English
DT Article
ID UNITED-STATES; SEX; RISK; PREVALENCE; TRENDS
AB This article addresses the challenge of developing HIV prevention interventions that not only prove to be efficacious but also are designed from the outset to overcome obstacles to reaching priority populations. We describe how community input has informed development of Keep It Up (KIU), a Community health screening and behavioral prevention program for young Black men. KIU embeds HIV prevention in a broader health promotion campaign, with the goal of reducing stigma and reaching a Population that bears a disproportionate burden of HIV/AIDS and other health problems-hypertension, high cholesterol, diabetes, asthma, and obesity. Information from community partners, expert advisers, and focus groups was collected at key junctures and incorporated into four core components: social marketing, a computerized behavioral learning module, biological testing for HIV and other conditions, and a personalized health profile and risk reduction plan. A pilot with 116 participants provided evidence that the KIU model of integrating HIV prevention with other health screening is acceptable and has the potential to reach Black men at risk for HIV as well as other chronic health conditions.
C1 [O'Donnell, Lydia; Agronick, Gail; Leow, Deborah McLean; Myint-U, Athi; Stueve, Ann] Educ Dev Ctr Inc, Hlth & Human Dev Programs, Newton, MA 02459 USA.
[Bonaparte, Beverly] CUNY Medgar Evers Coll, New York, NY USA.
[Joseph, Heather] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
RP O'Donnell, L (reprint author), Educ Dev Ctr Inc, Hlth & Human Dev Programs, 55 Chapel St, Newton, MA 02459 USA.
EM lodonnell@edc.org
FU NCHHSTP CDC HHS [5UR6PS000399]
NR 36
TC 7
Z9 7
U1 2
U2 4
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0899-9546
J9 AIDS EDUC PREV
JI Aids Educ. Prev.
PD AUG
PY 2009
VL 21
IS 4
BP 299
EP 313
PG 15
WC Education & Educational Research; Public, Environmental & Occupational
Health
SC Education & Educational Research; Public, Environmental & Occupational
Health
GA 481XI
UT WOS:000268845700001
PM 19670966
ER
PT J
AU Young, B
Buchacz, K
Moorman, A
Wood, KC
Brooks, JT
AF Young, Benjamin
Buchacz, Kate
Moorman, Anne
Wood, Kathy C.
Brooks, John T.
CA HIV Outpatient Study Hops Investig
TI Renal Function in Patients with Preexisting Renal Disease Receiving
Tenofovir-Containing Highly Active Antiretroviral Therapy in the HIV
Outpatient Study
SO AIDS PATIENT CARE AND STDS
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; TREATMENT-EXPERIENCED PATIENTS; DISOPROXIL
FUMARATE; CREATININE CLEARANCE; RANDOMIZED-TRIAL; SAFETY; DF;
MULTICENTER; INFECTION
AB Few data exist on the safety of tenofovir (TDF) in HIV-infected patients with preexisting renal dysfunction. We report 12-month changes in renal profiles among 19 such patients (6 patients with history of and 13 patients with current renal disease) in the HIV Outpatient Study (HOPS) who initiated TDF-containing highly active anti-retroviral therapy (HAART) during 2001-2005 with TDF dosed mostly at 300 mg once daily. At baseline, the median estimated glomerular filtration rate (GFR) was 49 mL/min/1.73 m(2) and the median CD4(+) cell count was 322 cells/mm(3). Patients had a median 12-month change in estimated creatinine clearance from baseline of -0.3 mL/min (range, -32.2 to +23.6) and the median change in GFR of -0.1 mL/min/1.73 m(2) (range, -49.8 to +29.5). We observed confirmed worsening of kidney disease stage in 5 of the 19 patients during follow-up. TDF use can be considered in patients with preexisting or current renal dysfunction who have limited antiretroviral treatment options, require TDF for fully active antiretroviral regimen, and can be closely monitored for incident worsening of renal function.
C1 [Young, Benjamin] Denver Infect Dis Consultants, Denver, CO 80220 USA.
[Young, Benjamin; Moorman, Anne] Hlth Connect Int, Amsterdam, Netherlands.
[Buchacz, Kate; Moorman, Anne; Brooks, John T.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA.
[Wood, Kathy C.] Cerner Corp, Vienna, VA USA.
RP Young, B (reprint author), Denver Infect Dis Consultants, 4545 E 9th Ave,Suite 120, Denver, CO 80220 USA.
EM byoung@didc.us
FU Centers for Disease Control and Prevention [200-2006-18797]; Bristol
Myers Squibb; Gilead Sciences; Merck; Roche; GlaxoSmithKline
FX B.Y. has received recent research grants from Bristol Myers Squibb,
Gilead Sciences, Merck, Roche, and GlaxoSmithKline and/or is a member of
advisory boards for Gilead Sciences, GlaxoSmithKline, Merck, Pfizer,
Roche and Bristol Myers Squibb. Other authors have no competing
financial interests exist.
NR 21
TC 17
Z9 18
U1 1
U2 1
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1087-2914
J9 AIDS PATIENT CARE ST
JI Aids Patient Care STDS
PD AUG
PY 2009
VL 23
IS 8
BP 589
EP 592
DI 10.1089/apc.2008.0232
PG 4
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 484RC
UT WOS:000269063600002
PM 19591609
ER
PT J
AU Khoury, MJ
Bertram, L
Boffetta, P
Butterworth, AS
Chanock, SJ
Dolan, SM
Fortier, I
Garcia-Closas, M
Gwinn, M
Higgins, JPT
Janssens, ACJW
Ostell, J
Owen, RP
Pagon, RA
Rebbeck, TR
Rothman, N
Bernstein, JL
Burton, PR
Campbell, H
Chockalingam, A
Furberg, H
Little, J
O'Brien, TR
Seminara, D
Vineis, P
Winn, DM
Yu, W
Ioannidis, JPA
AF Khoury, Muin J.
Bertram, Lars
Boffetta, Paolo
Butterworth, Adam S.
Chanock, Stephen J.
Dolan, Siobhan M.
Fortier, Isabel
Garcia-Closas, Montserrat
Gwinn, Marta
Higgins, Julian P. T.
Janssens, A. Cecile J. W.
Ostell, James
Owen, Ryan P.
Pagon, Roberta A.
Rebbeck, Timothy R.
Rothman, Nathaniel
Bernstein, Jonine L.
Burton, Paul R.
Campbell, Harry
Chockalingam, Anand
Furberg, Helena
Little, Julian
O'Brien, Thomas R.
Seminara, Daniela
Vineis, Paolo
Winn, Deborah M.
Yu, Wei
Ioannidis, John P. A.
TI Genome-Wide Association Studies, Field Synopses, and the Development of
the Knowledge Base on Genetic Variation and Human Diseases
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE association; database; encyclopedias; epidemiologic methods; genome;
human; genome-wide association study; genomics; meta-analysis
ID SYSTEMATIC METAANALYSES; BLADDER-CANCER; EPIDEMIOLOGY; VARIANTS; COMMON;
SUSCEPTIBILITY; REPLICATION; DATABASE; FALSE; LOCI
AB Genome-wide association studies (GWAS) have led to a rapid increase in available data on common genetic variants and phenotypes and numerous discoveries of new loci associated with susceptibility to common complex diseases. Integrating the evidence from GWAS and candidate gene studies depends on concerted efforts in data production, online publication, database development, and continuously updated data synthesis. Here the authors summarize current experience and challenges on these fronts, which were discussed at a 2008 multidisciplinary workshop sponsored by the Human Genome Epidemiology Network. Comprehensive field synopses that integrate many reported gene-disease associations have been systematically developed for several fields, including Alzheimer's disease, schizophrenia, bladder cancer, coronary heart disease, preterm birth, and DNA repair genes in various cancers. The authors summarize insights from these field synopses and discuss remaining unresolved issues-especially in the light of evidence from GWAS, for which they summarize empirical P-value and effect-size data on 223 discovered associations for binary outcomes (142 with P < 10(-7)). They also present a vision of collaboration that builds reliable cumulative evidence for genetic associations with common complex diseases and a transparent, distributed, authoritative knowledge base on genetic variation and human health. As a next step in the evolution of Human Genome Epidemiology reviews, the authors invite investigators to submit field synopses for possible publication in the American Journal of Epidemiology.
C1 [Khoury, Muin J.; Gwinn, Marta; Yu, Wei] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Bertram, Lars] Massachusetts Gen Hosp, Genet & Aging Res Unit, Charlestown, MA USA.
[Boffetta, Paolo] Int Agcy Res Canc, F-69372 Lyon, France.
[Butterworth, Adam S.; Higgins, Julian P. T.] Univ Cambridge, Mol Epidemiol Unit, Cambridge, England.
[Chanock, Stephen J.; Garcia-Closas, Montserrat; Rothman, Nathaniel; O'Brien, Thomas R.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Dolan, Siobhan M.] Montefiore Med Ctr, Albert Einstein Coll Med, Bronx, NY 10467 USA.
[Fortier, Isabel] McGill Univ, Quebec Innovat Ctr, Montreal, PQ, Canada.
[Higgins, Julian P. T.] Univ Cambridge, MRC, Biostat Unit, Cambridge, England.
[Janssens, A. Cecile J. W.] Erasmus Univ, Med Ctr, Rotterdam, Netherlands.
[Ostell, James] Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA.
[Owen, Ryan P.] Stanford Univ, Med Ctr, Stanford, CA 94305 USA.
[Pagon, Roberta A.] Univ Washington, Sch Med, Seattle, WA USA.
[Rebbeck, Timothy R.] Univ Penn, Sch Med, Philadelphia, PA 19104 USA.
[Bernstein, Jonine L.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA.
[Burton, Paul R.] Univ Leicester, Dept Hlth Sci, Leicester, Leics, England.
[Campbell, Harry] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland.
[Chockalingam, Anand] Univ Calif Berkeley, Div Epidemiol, Berkeley, CA 94720 USA.
[Furberg, Helena] Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
[Little, Julian] Univ Ottawa, Dept Epidemiol & Community Hlth, Ottawa, ON, Canada.
[Seminara, Daniela; Winn, Deborah M.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
[Vineis, Paolo] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol, London, England.
[Ioannidis, John P. A.] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, GR-45110 Ioannina, Greece.
[Ioannidis, John P. A.] Tufts Univ, Tufts Clin & Translat Sci Inst, Boston, MA 02111 USA.
[Ioannidis, John P. A.] Tufts Med Ctr, Ctr Genet Epidemiol & Modeling, Boston, MA USA.
RP Khoury, MJ (reprint author), Ctr Dis Control & Prevent, Off Publ Hlth Genom, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE, Atlanta, GA 30341 USA.
EM mukl@cdc.gov
RI Ioannidis, John/G-9836-2011; Higgins, Julian/H-4008-2011; Garcia-Closas,
Montserrat /F-3871-2015; Burton, Paul/H-7527-2016; Bertram,
Lars/K-3889-2015;
OI Higgins, Julian/0000-0002-8323-2514; Garcia-Closas, Montserrat
/0000-0003-1033-2650; Bertram, Lars/0000-0002-0108-124X; Janssens, A
Cecile/0000-0002-6153-4976
FU British Heart Foundation [RG/08/014/24067]; Medical Research Council
[MC_U105285807]; NCI NIH HHS [K07 CA118412, K07 CA118412-04]; NCRR NIH
HHS [UL1 RR025752]
NR 53
TC 81
Z9 82
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD AUG 1
PY 2009
VL 170
IS 3
BP 269
EP 279
DI 10.1093/aje/kwp119
PG 11
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 475BH
UT WOS:000268330300001
PM 19498075
ER
PT J
AU Knapp, MB
Grytdal, SP
Chiarello, LA
Sinkowitz-Cochran, RL
Zombeck, A
Klein, C
Warden, B
Lyden, J
Pearson, ML
AF Knapp, Megan Bush
Grytdal, Scott P.
Chiarello, Linda A.
Sinkowitz-Cochran, Ronda L.
Zombeck, Andrea
Klein, Cynthia
Warden, Beverly
Lyden, Jennifer
Pearson, Michele L.
TI Evaluation of institutional practices for prevention of
phlebotomy-associated percutaneous injuries in hospital settings
SO AMERICAN JOURNAL OF INFECTION CONTROL
LA English
DT Article
ID HEALTH-CARE WORKERS; NEEDLESTICK INJURIES; SHARPS INJURIES;
UNITED-STATES; EPIDEMIOLOGY; DEVICES
AB Background: To reduce the incidence of phlebotomy-related percutaneous injuries (PIs), factors that contribute to these injuries must be identified. This study examined institutional phlebotomy practices, policies, perceptions, and culture to identify facilitators and barriers that appear to have the greatest impact in preventing injuries.
Methods: During site visits at study hospitals, observational data were collected during the performance of phlebotomy In addition, interviews and focus groups were conducted with hospital personnel involved in phlebotomy procedures.
Results: Nine hospitals participated in the study A total of 126 phlebotomy procedures were observed. Health care personnel chose devices with safety features for the majority of observed procedures (n = 122, 97%). Recommended phlebotomy practices for handling needles after use were observed in 42% to 92% of procedures. Adherence varied by type of device, occupation, and facility PI rate. In the 23 interviews and 9 focus groups, participants identified factors that facilitated PI prevention such as the availability and use of devices with safety mechanisms, adherence to recommended safe needle-handling practices, and institutional phlebotomy training.
Conclusion: The quantitative and qualitative data indicate that a wide array of factors can affect phlebotomy-related practices and perceptions. Prevention of Pis may require comprehensive, multifaceted intervention efforts to improve the safety culture and reduce PIs and exposure to bloodborne pathogens in health care facilities. Copyright (C) 2009 by the Association for Professionals in infection Control and Epidemiology. Inc. (Am J Infect Control 2009;37;490-4.)
C1 [Knapp, Megan Bush; Grytdal, Scott P.; Chiarello, Linda A.; Sinkowitz-Cochran, Ronda L.; Pearson, Michele L.] Ctr Dis Control & Prevent, Prevent & Evaluat Branch, Div Healthcare Qual Promot, Natl Ctr Infect Dis,US Dept Hlth & Human Serv, Atlanta, GA 30333 USA.
[Zombeck, Andrea; Klein, Cynthia; Warden, Beverly; Lyden, Jennifer] Constella Grp LLC, Durham, NC USA.
RP Sinkowitz-Cochran, RL (reprint author), Ctr Dis Control & Prevent, Prevent & Evaluat Branch, Div Healthcare Qual Promot, Natl Ctr Infect Dis,US Dept Hlth & Human Serv, 1600 Clifton Rd MS A31, Atlanta, GA 30333 USA.
EM rls7@cdc.gov
NR 19
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-6553
J9 AM J INFECT CONTROL
JI Am. J. Infect. Control
PD AUG
PY 2009
VL 37
IS 6
BP 490
EP 494
DI 10.1016/j.ajic.2008.06.012
PG 5
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 482IJ
UT WOS:000268878500011
PM 19188001
ER
PT J
AU Dentinger, CM
AF Dentinger, Catherine M.
TI Hepatitis A
SO AMERICAN JOURNAL OF NURSING
LA English
DT Editorial Material
ID VIRAL-HEPATITIS; VIRUS; OUTBREAK; PROPHYLAXIS; PREVENTION; EXCRETION;
VACCINE
C1 [Dentinger, Catherine M.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Dentinger, Catherine M.] New York City Dept Hlth & Mental Hyg, New York, NY USA.
RP Dentinger, CM (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
EM cdentinger@cdc.gov
NR 24
TC 3
Z9 3
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0002-936X
J9 AM J NURS
JI Am. J. Nurs.
PD AUG
PY 2009
VL 109
IS 8
BP 29
EP 33
PG 5
WC Nursing
SC Nursing
GA 482UM
UT WOS:000268914300018
PM 19641403
ER
PT J
AU Farr, SL
Kraft, JM
Warner, L
Anderson, JE
Jamieson, DJ
AF Farr, Sherry L.
Kraft, Joan Marie
Warner, Lee
Anderson, John E.
Jamieson, Denise J.
TI The integration of STD/HIV services with contraceptive services for
young women in the United States
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article; Proceedings Paper
CT National Sexually Transmitted Disease Prevention Conference
CY MAR 10-14, 2008
CL Chicago, IL
DE adolescent; contraception; HIV; reproductive health service; sexually
transmitted disease
ID SEXUALLY-TRANSMITTED-DISEASES; HUMAN-IMMUNODEFICIENCY-VIRUS; MISSED
OPPORTUNITIES; REPRODUCTIVE HEALTH; PREVENTIVE SERVICES;
NATIONAL-SURVEY; ADOLESCENTS; CARE; VISITS; PROVIDERS
AB OBJECTIVE: The purpose of this study was to estimate the national prevalence and predictors of sexually transmitted disease/human immunodeficiency virus (STD/HIV) service receipt in the preceding year among young women who received contraceptive services.
STUDY DESIGN: Weighted self-reported data from the 2002 National Survey of Family Growth was used to estimate the prevalence and multivariable odds ratios for the receipt of STD/HIV services among 1009 unmarried, sexually active 15- to 24-year-old women who received contraceptive services.
RESULTS: Of the women who received contraceptive services, 35% (2.7 million) did not receive STD/HIV services. Predictors of the receipt of STD/HIV services included younger age at first sexual intercourse (<= 14 years; adjusted odds ratio [aOR], 2.0; 15-17 years; aOR, 1.7), having ever been pregnant (aOR, 2.2); having had >= 2 partners in the past year (aOR, 2.6), receipt of a pregnancy test or abortion in the past year (aOR, 2.3), and having visited a Title X clinic in the last 12 months (aOR, 3.3).
CONCLUSION: Interventions are needed to help integrate contraceptive and STD/HIV services.
C1 [Farr, Sherry L.; Kraft, Joan Marie; Warner, Lee; Anderson, John E.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA.
RP Farr, SL (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA.
NR 30
TC 5
Z9 5
U1 4
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD AUG
PY 2009
VL 201
IS 2
AR 142.e1
DI 10.1016/j.ajog.2009.04.018
PG 8
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 476RI
UT WOS:000268460900005
PM 19481723
ER
PT J
AU Henderson, ZT
Power, ML
Berghella, V
Lackritz, EM
Schulkin, J
AF Henderson, Zsakeba T.
Power, Michael L.
Berghella, Vincenzo
Lackritz, Eve M.
Schulkin, Jay
TI Attitudes and Practices Regarding Use of Progesterone to Prevent Preterm
Births
SO AMERICAN JOURNAL OF PERINATOLOGY
LA English
DT Article
DE Attitudes and practices; preterm birth; prevention; progesterone
ID CONTEMPORARY CLINICAL ISSUES; AMBULATORY RESEARCH NETWORK;
MATERNAL-FETAL MEDICINE; 17-ALPHA-HYDROXYPROGESTERONE CAPROATE;
OUTPATIENT OBSTETRICS; DOUBLE-BLIND; FOLLOW-UP; PLACEBO; TRIAL; WOMEN
AB We sought to describe current attitudes and practices of obstetrician-gynecologists regarding use of progesterone and prevention of preterm birth. A self-administered survey was mailed to American College of Obstetricians and Gynecologists Fellows and Junior Fellows in Practice in March to May 2007. The survey consisted of 36 questions, including respondents' demographic characteristics, preterm birth risk factor knowledge and screening practices, and use of progesterone for the prevention of preterm birth. The response rate was 52% (n = 345); most respondents were general obstetrician-gynecologists (89%). Many (74%) reported recommending or offering progesterone for prevention of preterm birth. Almost all (93%) reported use for the indication of previous spontaneous preterm birth. However, many also reported use for other indications such as dilated/effaced cervix (37%), short cervix on ultrasound (34%), and cerclage (26%). These results suggest that most obstetricians recommend or offer progesterone to prevent preterm birth for women with a previous spontaneous preterm birth and many also offer it for women with other high-risk obstetric conditions.
C1 [Henderson, Zsakeba T.; Lackritz, Eve M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA.
[Power, Michael L.; Schulkin, Jay] Amer Coll Obstetricians & Gynecologists, Res Dept, Washington, DC 20024 USA.
[Berghella, Vincenzo] Thomas Jefferson Univ, Dept Obstet & Gynecol, Div Maternal Fetal Med, Philadelphia, PA 19107 USA.
RP Henderson, ZT (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Highway,NE,Mailstop K-23, Atlanta, GA 30341 USA.
EM zhenderson@cdc.gov
OI Power, Michael/0000-0002-6120-3528; Berghella,
Vincenzo/0000-0003-2854-0239
NR 22
TC 9
Z9 9
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0735-1631
J9 AM J PERINAT
JI Am. J. Perinatol.
PD AUG
PY 2009
VL 26
IS 7
BP 529
EP 536
DI 10.1055/s-0029-1215432
PG 8
WC Obstetrics & Gynecology; Pediatrics
SC Obstetrics & Gynecology; Pediatrics
GA 475WQ
UT WOS:000268395600010
PM 19301227
ER
PT J
AU Lu, PJ
Euler, GL
Callahan, DB
AF Lu, Peng-jun
Euler, Gary L.
Callahan, David B.
TI Influenza Vaccination Among Adults with Asthma Findings from the 2007
BRFSS Survey
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID HIGH-RISK ADULTS; UNITED-STATES; PNEUMOCOCCAL POLYSACCHARIDE;
SELF-REPORT; COVERAGE; TRIAL
AB Background: Asthma prevalence among U.S. adults is estimated to be 6.7%. People with asthma are at increased risk of complications from influenza. Influenza vaccination of adults and children with asthma is recommended by the Advisory Committee oil Immunization Practices. The Healthy People 2010 Objectives call for annual influenza vaccination of at least 60% of adults aged 18-64 years with asthma and other conditions associated with an increased risk of complications from influenza.
Purpose: To assess influenza vaccination coverage among adults with asthma in the United States.
Methods: Data from the 2007 Behavioral Risk Factor Surveillance System restricted to individuals interviewed during February through August were analyzed in 2008 to estimate national and state prevalence of self-reported receipt of influenza vaccination among respondents aged 1.8-64 years with asthma. Logistic regression provided predictive marginal vaccination coverage for each covariate, adjusted for demographic and access to care characteristics.
Results: Among adults aged 18-64 years with asthma, influenza vaccination coverage was 39.9% (95% CI=38.3%, 41.5%) during the 2006-2007 season (coverage ranged from 26.9% [95% CI=19.8%, 35.3%] in California to 53.3% [95% CI=42.8%, 63.6%] in Tennessee). Influenza vaccination coverage was 33.9% (95% CI=31.9%, 35.9%) for adults aged 18-49 years with asthma compared to 54.7% (95% CI=52.4%, 57.0%) for adults aged 50-64 years with asthma. Among people aged 18-64 years, vaccination coverage was 28.8% among those without asthma. People with asthma who had an increased likelihood of vaccination were aged 50-64 years, female, non-Hispanic white, and had diabetes, activity limitations, health insurance, a regular healthcare provider, routine checkup in the previous year, and formerly smoked or never smoked.
Conclusions: influenza vaccination coverage continues to be below the national objective of 60% for people aged 18-64),cars with asthma as a high-risk condition. Increased state and national efforts are needed to improve influenza vaccination levels among this Population and particularly among those aged 18-49 years. (Am J Prev, Med 2009;37(2):109-115) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine
C1 [Lu, Peng-jun; Euler, Gary L.] CDC, Natl Ctr Immunizat & Resp Dis, Immunizat Serv Div, Atlanta, GA 30333 USA.
[Callahan, David B.] CDC, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Atlanta, GA 30333 USA.
RP Lu, PJ (reprint author), CDC, Natl Ctr Immunizat & Resp Dis, Immunizat Serv Div, 1600 Clifton Rd NE,Mail Stop E-62, Atlanta, GA 30333 USA.
EM lhp8@cdc.gov
NR 33
TC 23
Z9 25
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD AUG
PY 2009
VL 37
IS 2
BP 109
EP 115
DI 10.1016/j.amepre.2009.03.021
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 475FO
UT WOS:000268344200004
PM 19589448
ER
PT J
AU Gillespie, TR
Morgan, D
Sanz, C
Cameron, K
AF Gillespie, T. R.
Morgan, D.
Sanz, C.
Cameron, K.
TI LOGGING CREATES UNANTICIPATED THREAT TO APE HEALTH AND CONSERVATION IN
EQUATORIAL AFRICA
SO AMERICAN JOURNAL OF PRIMATOLOGY
LA English
DT Meeting Abstract
CT 32nd Annual Meeting of the American-Society-of-Primatologists
CY SEP 18-21, 2009
CL San Diego, CA
SP Amer Soc Primatol, San Diego Zoo, Mira Costa Coll
C1 [Gillespie, T. R.] Emory Univ, Dept Environm Studies, Atlanta, GA 30332 USA.
[Gillespie, T. R.] Emory Univ, Global Hlth Inst, Atlanta, GA 30332 USA.
[Gillespie, T. R.] US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Morgan, D.] Lincoln Pk Zoo, Chicago, IL USA.
[Sanz, C.] Washington Univ, St Louis, MO 63130 USA.
[Cameron, K.] Max Planck Inst Evolutionary Anthropol, Leipzig, Germany.
NR 0
TC 0
Z9 0
U1 3
U2 5
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0275-2565
J9 AM J PRIMATOL
JI Am. J. Primatol.
PD AUG
PY 2009
VL 71
MA 92
BP 59
EP 59
PG 1
WC Zoology
SC Zoology
GA 488SJ
UT WOS:000269369800093
ER
PT J
AU Loomis, D
Schulman, MD
Bailer, J
Stainback, K
Wheeler, M
Richardson, DB
Marshall, SW
AF Loomis, Dana
Schulman, Michael D.
Bailer, John
Stainback, Kevin
Wheeler, Matthew
Richardson, David B.
Marshall, Stephen W.
TI Political Economy of US States and Rates of Fatal Occupational Injury
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID UNITED-STATES; MORTALITY-RATES; SAFETY; HEALTH; TRENDS
AB Objectives. We investigated the extent to which the political economy of US states, including the relative power of organized labor, predicts rates of fatal occupational injury.
Methods. We described states' political economies with 6 contextual variables measuring social and political conditions: "right-to-work" laws, union membership density, labor grievance rates, state government debt, unemployment rates, and social wage payments. We obtained data on fatal occupational injuries from the National Traumatic Occupational Fatality surveillance system and population data from the US national census. We used Poisson regression methods to analyze relationships for the years 1980 and 1995.
Results. States differed notably with respect to political-economic characteristics and occupational fatality rates, although these characteristics were more homogeneous within rather than between regions. Industry and workforce composition contributed significantly to differences in state injury rates, but political-economic characteristics of states were also significantly associated with injury rates, after adjustment accounting for those factors.
Conclusions. Higher rates of fatal occupational injury were associated with a state policy climate favoring business over labor, with distinct regional clustering of such state policies in the South and Northeast. (Am J Public Health. 2009; 99:1400-1408. doi:10.2105/AJPH.2007.131409)
C1 [Loomis, Dana] Univ Nevada, Sch Publ Hlth, Reno, NV 89557 USA.
[Loomis, Dana; Richardson, David B.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
[Schulman, Michael D.] N Carolina State Univ, Dept Sociol & Anthropol, Raleigh, NC 27695 USA.
[Schulman, Michael D.] Univ N Carolina, Dept Hlth Behav & Hlth Educ, Chapel Hill, NC USA.
[Bailer, John] Miami Univ, Dept Math & Stat, Oxford, OH 45056 USA.
[Stainback, Kevin] Virginia Polytech Inst & State Univ, Dept Sociol, Blacksburg, VA 24061 USA.
[Wheeler, Matthew] NIOSH, Risk Evaluat Branch, Cincinnati, OH 45226 USA.
[Marshall, Stephen W.] Univ N Carolina, Dept Epidemiol & Orthapaed, Chapel Hill, NC USA.
RP Loomis, D (reprint author), Univ Nevada, Sch Publ Hlth, MS-274, Reno, NV 89557 USA.
EM dploomis@unr.edu
OI Marshall, Stephen/0000-0002-2664-9233
FU National Institute for Occupational Safety and Health [R01-OH03910]
FX We thank Eileen Gregory for assistance with processing data from the US
Census and Steve Lippmann, J. Scott Brown, and Suzanne Marsh for helpful
reviews of the article.
NR 29
TC 10
Z9 11
U1 1
U2 8
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD AUG
PY 2009
VL 99
IS 8
BP 1400
EP 1408
DI 10.2105/AJPH.2007.131409
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 482GZ
UT WOS:000268874100017
PM 19542025
ER
PT J
AU Coker, TR
Elliott, MN
Kanouse, DE
Grunbaum, JA
Gilliland, J
Tortolero, SR
Cuccaro, P
Schuster, MA
AF Coker, Tumaini R.
Elliott, Marc N.
Kanouse, David E.
Grunbaum, Jo Anne
Gilliland, Janice
Tortolero, Susan R.
Cuccaro, Paula
Schuster, Mark A.
TI Prevalence, Characteristics, and Associated Health and Health Care of
Family Homelessness Among Fifth-Grade Students
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID QUALITY-OF-LIFE; SHELTERED HOMELESS; MENTAL-HEALTH; SERVICE USE;
CHILDREN; PEDSQL(TM)-4.0; RELIABILITY; VALIDITY; MOTHERS; WOMEN
AB Objectives. We describe the lifetime prevalence and associated health-related concerns of family homelessness among fifth-grade students.
Methods. We used a population-based, cross-sectional survey of 5147 fifth-grade students in 3 US cities to analyze parent-reported measures of family homelessness, child health status, health care access and use, and emotional, developmental, and behavioral health and child-reported measures of health-related quality of life and exposure to violence.
Results. Seven percent of parents reported that they and their child had experienced homelessness (i.e., staying in shelters, cars, or on the street). Black children and children in the poorest families had the highest prevalence of homelessness (11%). In adjusted analyses, most general health measures were similar for children who had and had not been homeless. Children who had ever experienced homelessness were more likely to have an emotional, behavioral, or developmental problem (odds ratio [OR]=1.7; 95% confidence interval [CI]=1.1, 2.6; P=.01), to have received mental health care (OR=2.2; 95% CI=1.6, 3.2; P<.001), and to have witnessed serious violence with a knife (OR=1.6; 95% CI=11.1, 2.3; P=.007) than were children who were never homeless.
Conclusions. Family homelessness affects a substantial minority of fifth-grade children and may have an impact on their emotional, developmental, and behavioral health. (Am J Public Health. 2009;99:1446-1452. doi:10.2105/AJPH. 2008.147785)
C1 [Coker, Tumaini R.] Univ Calif Los Angeles, Dept Pediat, Mattel Childrens Hosp, David Geffen Sch Med, Los Angeles, CA 90024 USA.
[Coker, Tumaini R.; Elliott, Marc N.; Kanouse, David E.; Schuster, Mark A.] RAND Corp, Santa Monica, CA USA.
[Grunbaum, Jo Anne] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA USA.
[Gilliland, Janice] Univ Alabama Birmingham, Dept Maternal & Child Hlth, Birmingham, AL USA.
[Tortolero, Susan R.; Cuccaro, Paula] Univ Texas Houston, Hlth Sci Ctr, Ctr Hlth Promot & Prevent Res, Houston, TX USA.
[Schuster, Mark A.] Harvard Univ, Sch Med, Dept Med, Childrens Hosp Boston, Boston, MA USA.
RP Coker, TR (reprint author), Univ Calif Los Angeles, RAND Ctr Adolescent Hlth Promot, 1072 Gayley Ave, Los Angeles, CA 90024 USA.
EM tcoker@mednet.ucla.edu
OI Cuccaro, Paula/0000-0002-9551-4789
FU Centers for Disease Control and Prevention; Prevention Research Centers
[U48DP000046, U48DP000057, U48DP000056]
FX The Healthy Passages Study is funded by the Centers for Disease Control
and Prevention, Prevention Research Centers (cooperative agreements
U48DP000046, U48DP000057, and U48DP000056).; We thank Marika Suttorp,
MS, and Tariq Qureshi, MD, for their assistance in data analysis. We
also acknowledge Healthy Passages investigators and staff at each study
site, and express our gratitude to the families who participated in this
study.; Note. The findings and conclusions in this report are those of
the authors and do not necessarily represent the official position of
the Centers for Disease Control and Prevention.
NR 35
TC 10
Z9 10
U1 0
U2 3
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
EI 1541-0048
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD AUG
PY 2009
VL 99
IS 8
BP 1446
EP 1452
DI 10.2105/AJPH.2008.147785
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 482GZ
UT WOS:000268874100023
PM 19542035
ER
PT J
AU Kuempel, ED
Wheeler, MW
Smith, RJ
Vallyathan, V
Green, FHY
AF Kuempel, Eileen D.
Wheeler, Matthew W.
Smith, Randall J.
Vallyathan, Val
Green, Francis H. Y.
TI Contributions of Dust Exposure and Cigarette Smoking to Emphysema
Severity in Coal Miners in the United States
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article
DE occupational exposure; regression analysis; chronic obstructive lung
disease; autopsy; severity of illness index
ID CHRONIC OBSTRUCTIVE PULMONARY; WORKERS PNEUMOCONIOSIS;
RESPIRATORY-DISEASE; LUNG-FUNCTION; MORTALITY; AUTOPSY; IMPAIRMENT;
PATHOLOGY; AMERICAN; DEATH
AB Rationale: Previous studies have shown associations between dust exposure or lung burden and emphysema in coal miners, although the separate contributions of various predictors have not been clearly demonstrated.
Objectives: To quantitatively evaluate the relationship between cumulative exposure to respirable coal mine dust, cigarette smoking, and other factors on emphysema severity.
Methods: The study group included 722 autopsied coal miners and nonminers in the United States. Data on work history, smoking, race, and age at death were obtained from medical records and questionnaire completed by next-of-kin. Emphysema was classified and graded using a standardized schema. Job-specific mean concentrations of respirable coal mine dust were matched with work histories to estimate cumulative exposure. Relationships between various metrics of dust exposure (including cumulative exposure and lung dust burden) and emphysema severity were investigated in weighted least squares regression models.
Measurements and Main Results: Emphysema severity was significantly elevated in coal miners compared with nonminers among ever- and never-smokers (P < 0.0001). Cumulative exposure to respirable coal mine dust or coal dust retained in the lungs were significant predictors of emphysema severity (P < 0.0001) after accounting for cigarette smoking, age at death, and race. The contributions of coal mine dust exposure and cigarette smoking were similar in predicting emphysema severity averaged over this cohort.
Conclusions: Coal dust exposure, cigarette smoking, age, and race are significant and additive predictors of emphysema severity in this study.
C1 [Kuempel, Eileen D.; Wheeler, Matthew W.; Smith, Randall J.] NIOSH, Educ & Informat Div, Risk Evaluat Branch, Cincinnati, OH 45226 USA.
[Vallyathan, Val] NIOSH, Hlth Effects Lab Div, Pathol & Physiol Res Branch, Morgantown, WV USA.
[Green, Francis H. Y.] Univ Calgary, Fac Med, Dept Pathol, Calgary, AB, Canada.
RP Kuempel, ED (reprint author), NIOSH, Educ & Informat Div, Risk Evaluat Branch, 4676 Columbia Pkwy,MSC 15, Cincinnati, OH 45226 USA.
EM ekuempel@cdc.gov
FU National Institute for Occupational Safety and Health
FX Supported by The National Institute for Occupational Safety and Health.
NR 48
TC 34
Z9 34
U1 0
U2 8
PU AMER THORACIC SOC
PI NEW YORK
PA 1740 BROADWAY, NEW YORK, NY 10019-4374 USA
SN 1073-449X
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD AUG 1
PY 2009
VL 180
IS 3
BP 257
EP 264
DI 10.1164/rccm.200806-840OC
PG 8
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA 479XR
UT WOS:000268696000012
PM 19423717
ER
PT J
AU Dorman, SE
Johnson, JL
Goldberg, S
Muzanye, G
Padayatchi, N
Bozeman, L
Heilig, CM
Bernardo, J
Choudhri, S
Grosset, JH
Guy, E
Guyadeen, P
Leus, MC
Maltas, G
Menzies, D
Nuermberger, EL
Villarino, M
Vernon, A
Chaisson, RE
AF Dorman, Susan E.
Johnson, John L.
Goldberg, Stefan
Muzanye, Grace
Padayatchi, Nesri
Bozeman, Lorna
Heilig, Charles M.
Bernardo, John
Choudhri, Shurjeel
Grosset, Jacques H.
Guy, Elizabeth
Guyadeen, Priya
Leus, Maria Corazon
Maltas, Gina
Menzies, Dick
Nuermberger, Eric L.
Villarino, Margarita
Vernon, Andrew
Chaisson, Richard E.
CA TB Trials Consortium
TI Substitution of Moxifloxacin for Isoniazid during Intensive Phase
Treatment of Pulmonary Tuberculosis
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article
DE tuberculosis; antitubercular agents; mycobacterium infections
ID MYCOBACTERIUM-TUBERCULOSIS; BACTERICIDAL ACTIVITY; MURINE TUBERCULOSIS;
STERILIZING ACTIVITIES; IN-VITRO; GATIFLOXACIN; MODEL; PHARMACOKINETICS;
LEVOFLOXACIN; REGIMEN
AB Rationale Moxifloxacin has potent activity against Mycobacterium tuberculosis in vitro and in a mouse model of antituberculosis (TB) chemotherapy, but data regarding its activity in humans are limited. Objectives: Our objective was to compare the antimicrobial activity and safety of moxifloxacin versus isoniazid during the first 8 weeks of combination therapy for pulmonary TB.
Methods: Adults with sputum smear-positive pulmonary TB were randomly assigned to receive either moxifloxacin 400 mg plus isoniazid placebo, or isoniazid 300 ring plus moxifloxacin placebo, administered 5 days/week for 8 weeks, in addition to rifampin, pyrazinamide, and ethambutol. All doses were directly observed. Sputum was collected for culture every 2 weeks. The primary outcome was negative sputum culture at completion of 8 weeks of treatment.
Measurements and Main Results: Of 433 participants enrolled, 328 were eligible for the primary efficacy analysis. Of these, 35 (11%) were HIV positive, 248 (76%) had cavitation on baseline chest radiograph, and 213 (65%) were enrolled at African sites. Negative Cultures at Week 8 were observed in 90/164 (54.9%) participants in the isoniazid arm, and 99/164 (60.4%) in the moxifloxacin arm (P = 0.37). In multivariate analysis, cavitation and enrollment at an African site were associated with lower likelihood of Week-8 culture negativity. The proportion of participants who discontinued assigned treatment was 31/214 (14.5%) for the moxifloxacin group versus 22/205 (10.7%) for the isoniazid group (RR, 1.35; 95% CI, 0.81, 2.25).
Conclusions: Substitution of moxifloxacin for isoniazid resulted in a small but statistically nonsignificant increase in Week-8 culture negativity.
C1 [Dorman, Susan E.; Grosset, Jacques H.; Maltas, Gina; Nuermberger, Eric L.; Chaisson, Richard E.] Johns Hopkins Univ, Ctr TB Res, Baltimore, MD 21231 USA.
[Johnson, John L.] Case Western Reserve Univ, Div Infect Dis, Dept Med, Cleveland, OH 44106 USA.
[Johnson, John L.] Univ Hosp Case Med Ctr, Cleveland, OH USA.
[Goldberg, Stefan; Bozeman, Lorna; Heilig, Charles M.; Villarino, Margarita; Vernon, Andrew] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Muzanye, Grace] Uganda Case Western Reserve Univ Res Collaborat, Kampala, Uganda.
[Padayatchi, Nesri] Univ KwaZulu, CAPRISA, Kwa Zulu, South Africa.
[Padayatchi, Nesri] Univ KwaZulu, Dept Community Hlth, Kwa Zulu, South Africa.
[Bernardo, John] Boston Univ, Sch Med, Boston, MA 02118 USA.
[Choudhri, Shurjeel] Bayer Inc, West Haven, CT USA.
[Guy, Elizabeth] Baylor Coll Med, Houston, TX 77030 USA.
[Guyadeen, Priya] WESTAT Corp, Rockville, MD 20850 USA.
[Leus, Maria Corazon] Univ Med & Dent New Jersey, Newark, NJ 07103 USA.
[Menzies, Dick] McGill Univ, Montreal, PQ, Canada.
RP Dorman, SE (reprint author), Johns Hopkins Univ, Ctr TB Res, 1550 Orleans St,Room 1M-06, Baltimore, MD 21231 USA.
EM dsusan1@jhmi.edu
RI Heilig, Charles/C-2753-2008;
OI Heilig, Charles/0000-0003-1075-1310; Bernardo, John/0000-0002-3922-0559;
Mayanja-Kizza, Harriet/0000-0002-9297-6208; Joloba,
Moses/0000-0002-0334-9983; Stout, Jason/0000-0002-6698-8176
FU Centers for Disease Control and Prevention; Global Alliance for
Tuberculosis Drug Development
FX Supported by the Centers for Disease Control and Prevention and the
Global Alliance for Tuberculosis Drug Development. Bayer Pharmaceuticals
provided moxilloxacin and moxifloxacin placebo tablets.
NR 39
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U2 12
PU AMER THORACIC SOC
PI NEW YORK
PA 1740 BROADWAY, NEW YORK, NY 10019-4374 USA
SN 1073-449X
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD AUG 1
PY 2009
VL 180
IS 3
BP 273
EP 280
DI 10.1164/rccm.200901-0078OC
PG 8
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA 479XR
UT WOS:000268696000014
PM 19406981
ER
PT J
AU Ison, MG
Hager, J
Blumberg, E
Burdick, J
Carney, K
Cutler, J
DiMaio, JM
Hasz, R
Kuehnert, MJ
Ortiz-Rios, E
Teperman, L
Nalesnik, M
AF Ison, M. G.
Hager, J.
Blumberg, E.
Burdick, J.
Carney, K.
Cutler, J.
DiMaio, J. M.
Hasz, R.
Kuehnert, M. J.
Ortiz-Rios, E.
Teperman, L.
Nalesnik, M.
TI Donor-Derived Disease Transmission Events in the United States: Data
Reviewed by the OPTN/UNOS Disease Transmission Advisory Committee
SO AMERICAN JOURNAL OF TRANSPLANTATION
LA English
DT Article
CT 48th Annual Interscience Conference on Antimicrobial Agents and
Chemotherapy/46th Annual Meeting of the
Infectious-Diseases-Society-of-America
CY OCT 25, 2008
CL Washington, DC
SP Infect Dis Soc Amer
DE Donor risk; donor-to-host transmission; infectious diseases; malignancy
ID 4 TRANSPLANT RECIPIENTS; ORGAN DONOR; VIRUS
AB Donor-derived disease transmission is increasingly recognized as a source of morbidity and mortality among transplant recipients. Policy 4.7 of the Organ Procurement and Transplantation Network (OPTN) currently requires reporting of donor-derived events. All potential donor-derived transmission events (PDDTE) reported to OPTN/UNOS were reviewed by the Disease Transmission Advisory Committee (DTAC). Summary data from January 1, 2005-December 31, 2007, were prepared for presentation. Reports of PDDTE have increased from 7 in 2005, the first full year data were collected, to 60 in 2006 and to 97 in 2007. More detailed information is available for 2007; a classification system for determining likelihood of donor-derived transmission was utilized. In 2007, there were four proven and one possible donor-derived malignancy transmissions and four proven, two probable and six possible donor-derived infectious diseases transmissions. There were nine reported recipient deaths attributable to proven donor transmissions events arising from eight donors during 2007. Although recognized transmission events resulted in significant morbidity and mortality, transmission was reported in only 0.96% of deceased donor donations overall. Improved reporting, through enhanced recognition and communication, will be critical to better estimate the transmission risk of infection and malignancy through organ transplantation.
C1 [Ison, M. G.] Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA.
[Ison, M. G.] Northwestern Univ, Feinberg Sch Med, Div Organ Transplantat, Chicago, IL 60611 USA.
[Hager, J.] UNOS, Richmond, VA USA.
[Blumberg, E.] Univ Penn, Div Infect Dis, Philadelphia, PA 19104 USA.
[Burdick, J.] US Dept Hlth & Human Serv, HRSA, Rockville, MD USA.
[Carney, K.] Univ Penn, Dept Lung Transplantat, Philadelphia, PA 19104 USA.
[Cutler, J.] SW Transplant Alliance, Dallas, TX USA.
[DiMaio, J. M.] UT SW, Dept Cardiothorac Surg, Dallas, TX USA.
[Hasz, R.] Gift Life Donor Program, Philadelphia, PA USA.
[Kuehnert, M. J.] Ctr Dis Control & Prevent, Off Blood Organ & Other Tissue Safety Atlanta, Atlanta, GA USA.
[Ortiz-Rios, E.] HHS Rockville, HRSA, Rockville, MD USA.
[Teperman, L.] NYU, Dept Transplantat, New York, NY USA.
[Nalesnik, M.] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA.
RP Ison, MG (reprint author), Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA.
EM mgison@northwestern.edu
FU PHS HHS [234-2005-370011C]
NR 15
TC 93
Z9 96
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1600-6135
J9 AM J TRANSPLANT
JI Am. J. Transplant.
PD AUG
PY 2009
VL 9
IS 8
BP 1929
EP 1935
DI 10.1111/j.1600-6143.2009.02700.x
PG 7
WC Surgery; Transplantation
SC Surgery; Transplantation
GA 471IO
UT WOS:000268050200031
PM 19538493
ER
PT J
AU Goswami, ND
Shah, JJ
Corey, GR
Stout, JE
AF Goswami, Neela D.
Shah, J. Jina
Corey, G. Ralph
Stout, Jason E.
TI Short Report: Persistent Eosinophilia and Strongyloides Infection in
Montagnard Refugees after Presumptive Albendazole Therapy
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID PRE-DEPARTURE TREATMENT; INTESTINAL PARASITES; STERCORALIS; POPULATION;
CANADA; IMPACT
AB Chronic helminth infections are common in refugee populations and may persist years after immigration. Asymptomatic Strongyloides stercoralis infection raises particular concern because of its potential for complications in immunosuppressed patients. We examined 172 Montagnard refugees resettled to Wake County, North Carolina from 2002 through 2003. Refugees were pretreated with albendazole for five days and screened for health conditions after arrival. Eosinophilia was present in 41 of 171 refugees at the first blood draw. Only I of 172 had a stool helminth (Fasciola) identified by microscopy. On repeat testing, 13 people had persistent eosinophilia. Results of serologic analysis for Strongyloides were available in 24 persons. Eosinophil counts decreased significantly after treatment with ivermectin in nine refugees (P = 0.039). Persistent eosinophilia. likely caused by Strongyloides infection was common in this cohort of Montagnard refugees. Clinicians should understand the limitations of stool microscopy in diagnosis of strongyloidiasis, the limited effectiveness of albendazole in treating strongyloidiasis, and the importance of following-up refugees with persistent eosinophilia.
C1 [Goswami, Neela D.] Duke Univ, Med Ctr, Div Infect Dis, Dept Med, Durham, NC 27710 USA.
Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA.
RP Goswami, ND (reprint author), Duke Univ, Med Ctr, Div Infect Dis, Dept Med, Box 102359, Durham, NC 27710 USA.
EM dasgu001@mc.duke.edu
OI Stout, Jason/0000-0002-6698-8176
FU North Carolina Refugee Health Program; Enhanced Refugee Health
Assessment Program in Cambodia and North Carolina
FX We thank Debra S. Turner, who served as refugee health nurse for the
Wake County Human Services Clinic and without whose assistance this
study Would not have been possible. We also thank Suzanna Young (North
Carolina Refugee Health Program), Dr. Martin Cetron (Director, Division
of Global Migration and Quarantine. CDC). and other members of the IOM
and CDC team for assistance with the larger Enhanced Refugee Health
Assessment Program in Cambodia and North Carolina within which this
study is nested.
NR 13
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U1 0
U2 0
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD AUG
PY 2009
VL 81
IS 2
BP 302
EP 304
PG 3
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 475LK
UT WOS:000268360400023
PM 19635888
ER
PT J
AU Glenshaw, MT
Roy, S
Ruiz-Tiben, E
Downs, P
Williamson, J
Eberhard, M
AF Glenshaw, Mary T.
Roy, Sharon
Ruiz-Tiben, Ernesto
Downs, Philip
Williamson, John
Eberhard, Mark
TI Guinea Worm Disease Outcomes in Ghana: Determinants of Broken Worms
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID DRACUNCULIASIS ERADICATION; GLOBAL ERADICATION
AB In 2006,Ghana ranked second in Guinea worm disease (GWD) incidence and reported a previously undocumented 20% prevalence of worm breakage. A prospective study was conducted in 2007 to validate and describe worm breakage and determinants. Among 221 patients with known Outcomes. the worm breakage rate observed was 46%. After Controlling for demographics, worm and wound presentation, and treatment Course and provision, worm breakage was associated with narrow-diameter worms (< 2 mm) (adjusted odds ratio [AOR] 2.79; 95% confidence interval [CI] = 1.03-7.53). Protective factors against worm breakage included antibiotic ointment use (AOR 0.31; 95%, CI = 0.14-0.70), bandage protocol compliance (AOR: 0.38; 95% CI = 0.16-0.89), intact bandages (AOR 0.27; 95% CI = 0.09-0.82) and Moody compared with dry wounds (AOR 0.09; 95% CI = 0.01-0.7). The hit, We,it worm breakage rate observed warrants improvement in case management and patient care. Adherence to established treatment protocols Should be facilitated through improved provider training and supervision to reduce the disabling consequences of broken worms.
C1 [Glenshaw, Mary T.] Ctr Dis Control & Prevent, Epidem Intelligence Serv EIS, Atlanta, GA 30333 USA.
Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30333 USA.
Emory Univ, Carter Ctr, Guinea Worm Eradicat Program, Atlanta, GA 30322 USA.
RP Glenshaw, MT (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv EIS, 1600 Clifton Rd,NE,MS E-04, Atlanta, GA 30333 USA.
EM mglenshaw@cdc.gov
FU Kris Bisgard, CDC EIS Field Assignments Branch; New Jersey Department of
Health and Senior Services
FX We gratefully acknowledge Andrew Seidu-Korkor, National Coordinator,
GGWEP for his review of this manuscript, as well as the editing, review,
and supervision provided by Kris Bisgard, CDC EIS Field Assignments
Branch, Jerald Fagliano and Corwin Robertson, New Jersey Department of
Health and Senior Services. We especially thank Carter Center Technical
Assistants Corey Farrell and Alison Liang, and sincerely thank the data
collection staff. treatment providers, and patients for their
participation ill this evaluation.
NR 13
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U1 0
U2 2
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD AUG
PY 2009
VL 81
IS 2
BP 305
EP 312
PG 8
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 475LK
UT WOS:000268360400024
PM 19635889
ER
PT J
AU Stacey, P
Kauffer, E
Moulut, JC
Dion, C
Beauparlant, M
Fernandez, P
Key-Schwartz, R
Friede, B
Wake, D
AF Stacey, Peter
Kauffer, Edmond
Moulut, Jean-Claude
Dion, Chantal
Beauparlant, Martin
Fernandez, Pablo
Key-Schwartz, Rosa
Friede, Bernd
Wake, Derrick
TI An International Comparison of the Crystallinity of Calibration
Materials for the Analysis of Respirable alpha-Quartz Using X-Ray
Diffraction and a Comparison with Results from the Infrared KBr Disc
Method
SO ANNALS OF OCCUPATIONAL HYGIENE
LA English
DT Article
DE analysis; crystallinity; infrared; quartz; silica; x-ray diffraction
ID PARTICLE-SIZE; STANDARDS; SPECTROPHOTOMETRY
AB This paper lists the values recommended by the working group for use with XRD analysis. The values for crystallinity obtained for some of the materials (NIST 1878, Min-U-Sil5 and A9950) were 6-7% lower than the original certification or estimates reported in other comparisons. Crystallinity values obtained by XRD gave a good correlation with BET surface area measurements (r(2) = 0.91) but not with mean aerodynamic particle size (r(2) = 0.31). Subsamples of two of the materials (A9950 Respirable and Quin 1 Respirable) with smaller particle size distribution than their parent material did not show any significant change in their values for crystallinity, suggesting that the area XRD measurement of these materials within the particle size range collected is more dependent on how the quartz is formed geologically or how it is processed for use. A comparison of results from laboratories using the infrared (IR) and KBr disc method showed that this method is more dependent than XRD on differences in the particle size within the respirable size range, whereas the XRD values were more consistent between the different measurement values obtained on each material. It was not possible to assign a value for percentage purity to each material for users of IR analysis.
This work suggests that differences are likely to exist between the results from XRD and IR analysis when measuring 'real' workplace samples and highlights the importance of matching the particle size of the calibration material to the particle size of the workplace dust for measurements of crystalline quartz.
C1 [Stacey, Peter; Wake, Derrick] Hlth & Safety Lab, Buxton SK17 9JN, England.
[Kauffer, Edmond; Moulut, Jean-Claude] Inst Natl Rech & Secur, F-54501 Vandoeuvre Les Nancy, France.
[Dion, Chantal; Beauparlant, Martin] Inst Rech Robert Sauve Sante & Secur Travail, Montreal, PQ H3A 3C2, Canada.
[Fernandez, Pablo] Inst Nacl Silicosis, Oviedo 33006, Spain.
[Key-Schwartz, Rosa] NIOSH, Cincinnati, OH 45226 USA.
[Friede, Bernd] Elkem Mat R&D, N-4675 Kristiansand, Norway.
RP Stacey, P (reprint author), Hlth & Safety Lab, Buxton SK17 9JN, England.
EM Peter.Stacey@hsl.gov.uk
FU United States Centres for Disease Control; Department for Health and
Human Services
FX Glen Mcconnachie for his IR KBr disc analyses at HSL, Alain Masson for
his IR KBr disc analyses at INRS, Martin Roff at HSL for his advice on
statistics, Claudette Dufresne for her collaboration in the collection
of data by XRD at Institut de recherche 'Robert-Sauve' en sante et en
securite du travail, and Peter Griffin at the Health and Safety
Executive in the UK for his support in the preparation of this paper.
The mention of company names does not constitute endorsement by the
United States Centres for Disease Control, Department for Health and
Human Services.
NR 19
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U1 2
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0003-4878
J9 ANN OCCUP HYG
JI Ann. Occup. Hyg.
PD AUG
PY 2009
VL 53
IS 6
BP 639
EP 649
DI 10.1093/annhyg/mep038
PG 11
WC Public, Environmental & Occupational Health; Toxicology
SC Public, Environmental & Occupational Health; Toxicology
GA 483WE
UT WOS:000269001100009
PM 19531809
ER
PT J
AU Kitchel, B
Rasheed, JK
Patel, JB
Srinivasan, A
Navon-Venezia, S
Carmeli, Y
Brolund, A
Giske, CG
AF Kitchel, Brandon
Rasheed, J. Kamile
Patel, Jean B.
Srinivasan, Arjun
Navon-Venezia, Shiri
Carmeli, Yehuda
Brolund, Alma
Giske, Christian G.
TI Molecular Epidemiology of KPC-Producing Klebsiella pneumoniae Isolates
in the United States: Clonal Expansion of Multilocus Sequence Type 258
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID HYDROLYZING BETA-LACTAMASE; CARBAPENEM-RESISTANT STRAIN; FIELD
GEL-ELECTROPHORESIS; NEW-YORK; PSEUDOMONAS-AERUGINOSA; MEDICAL-CENTER;
PLASMID; EMERGENCE; BROOKLYN; ISRAEL
AB Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have become more common in the United States and throughout the world. We used pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) to examine the molecular epidemiology of KPC-producing K. pneumoniae isolates sent to the Centers for Disease Control and Prevention (CDC) for reference testing from 1996 to 2008. A dominant strain, sequence type 258 (ST 258), was found and likely accounts for 70% of the CDC's K. pneumoniae PFGE database. Isolates with PFGE patterns related to ST 258 were identified in 10 of the 19 U. S. states currently reporting KPC-producing K. pneumoniae, in addition to one isolate from Israel. KPC subtyping and analysis of the surrounding genetic environment were subsequently performed on 23 representative isolates. Thirteen isolates identified as ST 258 possessed either bla(KPC-2) or bla(KPC-3) and some variability in the Tn4401 element upstream of the bla(KPC) gene. Escherichia coli DH10B was successfully transformed by electroporation with KPC-encoding plasmid DNA from 20 of the 23 isolates. Restriction analysis of plasmid DNA prepared from transformants revealed a diversity of band patterns, suggesting the presence of different plasmids harboring the bla(KPC) gene, even among isolates of the same ST.
C1 [Kitchel, Brandon; Rasheed, J. Kamile; Patel, Jean B.; Srinivasan, Arjun] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA.
[Navon-Venezia, Shiri; Carmeli, Yehuda] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Div Epidemiol, IL-69978 Tel Aviv, Israel.
[Brolund, Alma; Giske, Christian G.] Karolinska Univ Hosp Solna, Karolinska Inst, MTC, SE-17176 Stockholm, Sweden.
RP Kitchel, B (reprint author), Mailstop G08,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM bkitchel@cdc.gov
NR 34
TC 268
Z9 276
U1 2
U2 17
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD AUG
PY 2009
VL 53
IS 8
BP 3365
EP 3370
DI 10.1128/AAC.00126-09
PG 6
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 471ZW
UT WOS:000268098300027
PM 19506063
ER
PT J
AU Jadhao, SJ
Nguyen, DC
Uyeki, TM
Shaw, M
Maines, T
Rowe, T
Smith, C
Huynh, LPT
Nghiem, HK
Nguyen, DHT
Nguyen, HKL
Nguyen, HHT
Hoang, LT
Nguyen, T
Phuong, LS
Klimov, A
Tumpey, TM
Cox, NJ
Donis, RO
Matsuoka, Y
Katz, JM
AF Jadhao, Samadhan J.
Nguyen, Doan C.
Uyeki, Timothy M.
Shaw, Michael
Maines, Taronna
Rowe, Thomas
Smith, Catherine
Huynh, Lien P. T.
Nghiem, Ha K.
Nguyen, Diep H. T.
Nguyen, Hang K. L.
Nguyen, Hanh H. T.
Hoang, Long T.
Nguyen, Tung
Phuong, Lien S.
Klimov, Alexander
Tumpey, Terrence M.
Cox, Nancy J.
Donis, Ruben O.
Matsuoka, Yumiko
Katz, Jacqueline M.
TI Genetic analysis of avian influenza A viruses isolated from domestic
waterfowl in live-bird markets of Hanoi, Vietnam, preceding fatal H5N1
human infections in 2004
SO ARCHIVES OF VIROLOGY
LA English
DT Article
ID HIGHLY PATHOGENIC H5N1; HONG-KONG; MOLECULAR-BASIS; SOUTHERN CHINA;
AMINO-ACID; NS1 GENE; HEMAGGLUTININ; EVOLUTION; POULTRY; ASIA
AB The first known cases of human infection with highly pathogenic avian influenza (HPAI) H5N1 viruses in Vietnam occurred in late 2003. However, HPAI H5N1 and low-pathogenic avian influenza (LPAI) H5N2 and H9N3 viruses were isolated from domestic waterfowl during live-bird market (LBM) surveillance in Vietnam in 2001 and 2003. To understand the possible role of these early viruses in the genesis of H5N1 strains infecting people, we performed sequencing and molecular characterization. Phylogenetic analysis revealed that the hemagglutinin (HA) genes of two geese HPAI H5N1 strains belonged to clade 3, and their surface glycoprotein and replication complex genes were most closely related (98.5-99.7% homologous) to A/duck/Guangxi/22/01 (H5N1) virus, detected contemporarily in southern China, whilst the M and NS genes were derived from an A/duck/Hong Kong/2986.1/00 (H5N1)-like virus. The H5 HA gene of the duck HPAI H5N1 strain belonged to clade 5 and acquired a gene constellation from A/quail/Shantou/3846/02 (H5N1), A/teal/China/2978.1/02 (H5N1) and A/partridge/Shantou/2286/03 (H5N1)-like viruses. The phylogenetic analysis further indicated that all eight gene segments of goose and duck HPAI H5N1 and LPAI H5N2 viruses were distinct from those of H5N1 clade-1 viruses known to have caused fatal human infections in Vietnam since late 2003. The duck H9N3 isolates derived genes from aquatic-bird influenza viruses, and their H9 HA belonged to the Korean lineage. The PB2 gene of A/duck/Vietnam/340/01 (H9N3) virus had lysine at position 627. Based on the molecular characterization of specific amino acid residues in the surface and relevant internal protein-coding genes, the Vietnamese H5N1 and H9N3 virus isolates indicated specificity to avian cell surface receptor and susceptibility for currently licensed anti-influenza A virus chemotherapeutics. Our findings suggest that the H5N1 and H5N2 viruses that circulated among geese and ducks in LBMs in Hanoi, Vietnam, during 2001 and 2003 were not the immediate ancestors of the clade-1 viruses associated with fatal human infections in Vietnam. The clade-1 HPAI H5N1 viruses were independently introduced into Vietnam.
C1 [Jadhao, Samadhan J.; Nguyen, Doan C.; Uyeki, Timothy M.; Shaw, Michael; Maines, Taronna; Rowe, Thomas; Smith, Catherine; Klimov, Alexander; Tumpey, Terrence M.; Cox, Nancy J.; Donis, Ruben O.; Matsuoka, Yumiko; Katz, Jacqueline M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Huynh, Lien P. T.; Nghiem, Ha K.; Nguyen, Hang K. L.; Nguyen, Hanh H. T.; Hoang, Long T.] Natl Inst Hyg & Epidemiol, Hanoi, Vietnam.
[Nguyen, Diep H. T.; Nguyen, Tung; Phuong, Lien S.] Natl Ctr Vet Diag, Hanoi, Vietnam.
RP Donis, RO (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, MS-G16,1600 Clifton Rd NE, Atlanta, GA 30333 USA.
EM Samadhan.Jadhao@ars.usda.gov; RDonis@cdc.gov
FU International Emerging Infectious Disease Fellowship at the US Centers
for Disease Control and Prevention
FX We thank the National Institute of Hygiene and Epidemiology and National
Center for Veterinary Diagnosis, Hanoi, Vietnam, for invaluable
leadership in conducting of outbreak investigations. SJJ and DCN were
supported by International Emerging Infectious Disease Fellowship at the
US Centers for Disease Control and Prevention and administered by the
Association of Public Health Laboratories, USA. We thank P. Rivailler
for sequence data annotation and management. The findings and
conclusions in this report are those of the authors and do not
necessarily represent the views of the Centers for Disease Control and
Prevention or the Agency for Toxic Substances and Disease Registry.
NR 44
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U1 1
U2 7
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0304-8608
J9 ARCH VIROL
JI Arch. Virol.
PD AUG
PY 2009
VL 154
IS 8
BP 1249
EP 1261
DI 10.1007/s00705-009-0429-2
PG 13
WC Virology
SC Virology
GA 492VA
UT WOS:000269687400008
PM 19578928
ER
PT J
AU Costa, P
Briggs, DJ
Tumpey, A
Dedmon, R
Coutts, J
AF Costa, Peter
Briggs, Deborah J.
Tumpey, Abbigail
Dedmon, Robert
Coutts, Jane
TI World Rabies Day outreach to Asia: empowering people through education
SO ASIAN BIOMEDICINE
LA English
DT Article
DE Awareness; communication; education; rabies prevention; World Rabies Day
ID DOGS
AB In its first two years of implementation, (2007 and 2008), the World Rabies Day initiative has proven to be an extremely effective focal point around which to increase global educational awareness about how to prevent rabies. World Rabies Day has been endorsed by a multinational group of global stakeholders including international health organizations, national governments, educational institutions, NGOs and industry, as well as those individuals living at daily risk of exposure. In 2007, 75% of all reported participants in World Rabies Day activities came from Asian countries. In 2008, 22 Asian countries participated in World Rabies' Day activities and the number of animals reported to be vaccinated in association with World Rabies Day reached nearly 617,000 in Asia alone. Personal accounts from individual event coordinators demonstrated the dimensions of the growing campaign throughout Asia. The manuscript will provide a review of outreach conducted to the continent of Asia for the first two World Rabies Day initiatives.
C1 [Costa, Peter; Briggs, Deborah J.; Dedmon, Robert; Coutts, Jane] Alliance Rabies Control, Edinburgh, Midlothian, Scotland.
[Costa, Peter; Briggs, Deborah J.; Dedmon, Robert; Coutts, Jane] Global Alliance Rabies Control, Manhattan, KS 66506 USA.
[Briggs, Deborah J.] Kansas State Univ, Coll Vet Med, Manhattan, KS 66502 USA.
[Tumpey, Abbigail] Ctr Dis Control & Prevent, Atlanta, GA 30017 USA.
[Dedmon, Robert] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
RP Costa, P (reprint author), 65 Eagle Stone Ridge, Youngsville, NC 27596 USA.
EM peter.costa@worldrabiesday.org
NR 11
TC 2
Z9 2
U1 0
U2 4
PU CHULALONGKORN UNIV, FAC MED
PI BANGKOK
PA CHULALONGKORN UNIV, FAC MED, 1873, RAMA 4, BANGKOK, 10330, THAILAND
SN 1905-7415
J9 ASIAN BIOMED
JI Asian Biomed.
PD AUG
PY 2009
VL 3
IS 4
BP 451
EP 457
PG 7
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 488TS
UT WOS:000269373600014
ER
PT J
AU Rigsby, P
Ison, C
Brierley, M
Ballard, R
Hagedorn, HJ
Lewis, DA
Notermans, DW
Riis, J
Robertson, P
Seppala, IJT
Rijpkema, S
AF Rigsby, Peter
Ison, Catherine
Brierley, Matthew
Ballard, Ron
Hagedorn, Hans-Jochen
Lewis, David A.
Notermans, Daan W.
Riis, Jorn
Robertson, Peter
Seppala, Ilkka J. T.
Rijpkema, Sjoerd
TI Evaluation of two human plasma pools as candidate international standard
preparations for syphilitic antibodies
SO BIOLOGICALS
LA English
DT Article
DE Syphilis; Serodiagnosis; Antibodies; International standard preparations
ID PROGRAM
AB A collaborative study was designed to asses two freeze-dried human plasma preparations containing anti-Treponema pallidum antibodies, 051 132 and 05/122, for their suitability as international reference reagents for syphilis serology. Both preparations are intended as replacements of the first international standard (IS) for syphilitic serum antibodies (HS). Samples were tested by eight laboratories using the T. pallidum passive particle agglutination assay (TPPA), the venereal disease research laboratory test (VDRL) and the rapid plasma reagin test (RPR). In addition a range of immunoassays was also used. The outcome of the collaborative study revealed that candidate standard 05/132 contains T. pallidum-specific IgG and IgM and is reactive in VDRL or RPR, and that 05/122 contains T. pallidum-specific IgG but is not reactive in either the VDRL or RPR test. Both 05/132 and 05/122 are reactive in the TPPA. On the basis of these results the Expert Committee on Biological Standardization of the World Health Organization designated 05/132 as the 1st IS for human syphilitic plasma IgG and IgM with a unitage of 3 IU per ampoule relative to HS and 05/122 as the 1st IS for human syphilitic plasma IgG with a unitage of 300 mIU per ampoule relative to 05/132. (C) 2009 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.
C1 [Rijpkema, Sjoerd] Natl Inst Biol Stand & Controls, Div Bacteriol, Potters Bar EN6 3QG, Herts, England.
[Rigsby, Peter; Brierley, Matthew] Natl Inst Biol Stand & Controls, Biostat Sect, Potters Bar EN6 3QG, Herts, England.
[Ison, Catherine] Ctr Infect, Hlth Protect Agcy, Sexually Transmitted Bacteria Reference Lab, Colindale, England.
[Ballard, Ron] Ctr Dis Control & Prevent, Lab Reference, Atlanta, GA USA.
[Ballard, Ron] Ctr Dis Control & Prevent, Res Branch, Div STD Prevent, Atlanta, GA USA.
[Hagedorn, Hans-Jochen] Lab Dr Krone & Partner, Bad Salzuflen, Germany.
[Lewis, David A.] Natl Inst Communicable Dis NHLS, Sexually Transmitted Infect Reference Ctr, Johannesburg, South Africa.
[Notermans, Daan W.] Natl Inst Publ Hlth & Environm RIVM, Diagnost Lab Infect Dis, Bilthoven, Netherlands.
[Riis, Jorn] Statens Serum Inst, Dept Clin Biochem, DK-2300 Copenhagen, Denmark.
[Robertson, Peter] Prince Wales Hosp, SEALS Area Serol Lab, Randwick, NSW 2031, Australia.
[Seppala, Ilkka J. T.] Helsinki Univ Hosp, Immunol Unit, HUSLAB, Helsinki, Finland.
[Notermans, Daan W.] Natl Inst Publ Hlth & Environm RIVM, Perinatal Screening Ctr Infect Dis Control, Bilthoven, Netherlands.
RP Rijpkema, S (reprint author), Natl Inst Biol Stand & Controls, Div Bacteriol, Blanche Lane, Potters Bar EN6 3QG, Herts, England.
EM sfijpkema@nibsc.ac.uk
NR 13
TC 1
Z9 2
U1 0
U2 1
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1045-1056
J9 BIOLOGICALS
JI Biologicals
PD AUG
PY 2009
VL 37
IS 4
BP 245
EP 251
DI 10.1016/j.biologicals.2009.03.002
PG 7
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Pharmacology & Pharmacy
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Pharmacology & Pharmacy
GA 495ZO
UT WOS:000269936400007
PM 19375942
ER
PT J
AU Grillet, ME
Martinez, JE
Barrera, R
AF Grillet, Maria-Eugenia
Eudes Martinez, Juan
Barrera, Roberto
TI Malaria hot spot areas: Implications for effective and targeted
interventions in Venezuela
SO BOLETIN DE MALARIOLOGIA Y SALUD AMBIENTAL
LA Spanish
DT Article
DE heterogeneity; local spatial dependency; spatial epidemiology;
Plasmodium vivax; Venezuela
ID SPATIAL-PATTERNS; NORTHEASTERN VENEZUELA; INFECTIOUS-DISEASES;
ANOPHELES-AQUASALIS; SUCRE STATE; EPIDEMIOLOGY; DYNAMICS; TRANSMISSION;
CULICIDAE; CLUSTERS
AB This study describes the temporal and spatial pattern of malaria in northeastern Venezuela during a 12 year period in order to detect hot spots or areas of high Plasmodium vivax incidence. The underlying hypothesis is that malaria transmission is highly heterogeneous and rather local in nature, consequently, the infectious risk is not homogeneous in the landscape. Clustering of disease in two geographical areas (Cajigal and Benitez municipalities) within the Sucre state were detected by Kulldorff scan statistic, with a 8.9-fold increased risk of malaria inside the cluster, as compared to outside the area (P < 0.001, all 12 years). One-twelve hot spots of malaria transmission were detected both in epidemic and non-epidemic years in these two regions using the local Getis (P < 0.05). Hot spots accounted for 67 - 90% of parasite transmission in each municipality. The spatial extent or scale of the malaria process around each hot spot varied between 1-5 km. Non-focalized control strategy has reduced the malaria incidence in the region, but transmission remains in persistent foci that are potential sources of outbreaks and spreading of P. vivax to other areas within the Sucre state. This study exemplifies the importance of stratifying the spatial risk of disease for an efficient and more effective control of malaria transmission in northeastern Venezuela.
C1 [Grillet, Maria-Eugenia; Eudes Martinez, Juan] Cent Univ Venezuela, Fac Ciencias, Inst Zool & Ecol Trop, Lab Biol Vectores, Caracas 1041A, Venezuela.
[Barrera, Roberto] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne & Infect Dis, San Juan, PR USA.
RP Grillet, ME (reprint author), Cent Univ Venezuela, Fac Ciencias, Inst Zool & Ecol Trop, Lab Biol Vectores, Apartado Postal 47072, Caracas 1041A, Venezuela.
EM maria.grillet@ciens.ucv.ve
NR 35
TC 5
Z9 5
U1 0
U2 1
PU INST ALTOS ESTUDIOS, DR ARNOLDO GABOLDON
PI MARACAY
PA APARTADO POSTAL 2442, MARACAY, ZP 2101, VENEZUELA
SN 1690-4648
J9 B MALARIOL SALUD AMB
JI Bol. Malar. Salud. Ambient.
PD AUG-DEC
PY 2009
VL 49
IS 2
BP 193
EP 208
PG 16
WC Infectious Diseases; Parasitology
SC Infectious Diseases; Parasitology
GA 595NC
UT WOS:000277616600004
ER
PT J
AU Ma, HY
Wang, YP
Sullivan-Halley, J
Weiss, L
Burkman, RT
Simon, MS
Malone, KE
Strom, BL
Ursin, G
Marchbanks, PA
McDonald, JA
Spirtas, R
Press, MF
Bernstein, L
AF Ma, Huiyan
Wang, Yaping
Sullivan-Halley, Jane
Weiss, Linda
Burkman, Ronald T.
Simon, Michael S.
Malone, Kathleen E.
Strom, Brian L.
Ursin, Giske
Marchbanks, Polly A.
McDonald, Jill A.
Spirtas, Robert
Press, Michael F.
Bernstein, Leslie
TI Breast Cancer Receptor Status: Do Results from a Centralized Pathology
Laboratory Agree with SEER Registry Reports?
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID PROGESTERONE-RECEPTOR; ESTROGEN-RECEPTOR; HORMONE-RECEPTOR;
RISK-FACTORS; MONOCLONAL-ANTIBODIES; WOMEN; AGE; IMMUNOHISTOCHEMISTRY;
LOCALIZATION; ESTROPHILIN
AB We investigated the extent to which estrogen receptor (ER) and progesterone receptor (PR) status results from a centralized pathology laboratory agree with ER and PR results from community pathology laboratories reported to two Surveillance, Epidemiology and End Results (SEER) registries (Los Angeles County and Detroit) and whether statistical estimates for the association between reproductive factors and breast cancer receptor subtypes differ by the source of data. The agreement between the centralized laboratory and SEER registry classifications was substantial for ER (kappa = 0.70) and nearly so for PR status (kappa = 0.60). Among the four subtypes defined by joint ER and PR status, the agreement between the two sources was substantial for the two major breast cancer subtypes (ER-/PR-, kappa = 0.69; ER+/PR+, kappa = 0.62) and poor for the two rarer subtypes (ER+/PR-, kappa = 0.30; ER-/PR+, kappa = 0.05). Estimates for the association between reproductive factors (number of full-term pregnancies, age at first full-term pregnancy, and duration of breastfeeding) and the two major subtypes (ER+/PR+ and ER-/PR-) differed minimally between the two sources of data. For example, parous women with at least four full-term pregnancies had 40% lower risk for ER+/PR+ breast cancer than women who had never been pregnant [centralized laboratory, odds ratio, 0.60 (95% confidence interval, 0.39-0.92); SEER, odds ratio, 0.57 (95% confidence interval, 0.38-0.85)]; no association was observed for ER-/PR- breast cancer (both P(trend) > 0.30). Our results suggest that conclusions based on SEER registry data are reasonably reliable for ER+/PR+ and ER-/PR- subtypes. (Cancer Epidemiol Biomarkers Prev 2009;18(8):2214-20)
C1 [Ma, Huiyan; Sullivan-Halley, Jane; Bernstein, Leslie] City Hope Natl Med Ctr, Dept Populat Sci, Div Canc Etiol, Duarte, CA 91010 USA.
[Wang, Yaping; Bernstein, Leslie] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
[Press, Michael F.] Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90033 USA.
[Marchbanks, Polly A.; McDonald, Jill A.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA.
[Burkman, Ronald T.] Baystate Med Ctr, Dept Obstet & Gynecol, Springfield, MA USA.
[Simon, Michael S.] Wayne State Univ, Karmanos Canc Inst, Div Hematol Oncol, Detroit, MI USA.
[Malone, Kathleen E.] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.
[Strom, Brian L.] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
[Ursin, Giske] Univ Oslo, Dept Nutr, Oslo, Norway.
[Weiss, Linda] NCI, Canc Ctr Branch, Bethesda, MD 20892 USA.
[Spirtas, Robert] NICHD, Contracept & Reprod Hlth Branch, Populat Res Ctr, Bethesda, MD USA.
RP Bernstein, L (reprint author), City Hope Natl Med Ctr, Dept Populat Sci, Div Canc Etiol, 1500 E Duarte Rd, Duarte, CA 91010 USA.
EM LBernstein@coh.org
FU National Institute for Child Health and Human Development
[NO1-HD-3-3175]; National Cancer Institute [CA48780]; Emory University
[N01-HD-3-3168]; Fred Hutchinson Cancer Research Center [N01-HD-2-3166];
Karmanos Cancer Institute at Wayne State University [N01-HD-3-3174];
University of Pennsylvania [NO1-HD-3-3276]; University of Southern
California [N01-HD-3-3175]; Centers for Disease Control and Prevention
[Y01-HD-7022]; California Department of Health Services [103885];
[N01-PC-67006]; [N01-CN-65064]; [N01-PC-67010]; [N01-CN-0532]
FX Grant support: Contract from the National Institute for Child Health and
Human Development (NO1-HD-3-3175) and a grant from the National Cancer
Institute (CA48780); data collection for the Women's Contraceptive and
Reproductive Experiences study supported by National Institute of Child
Health and Human Development and National Cancer Institute, NIH, through
contracts with Emory University (N01-HD-3-3168), Fred Hutchinson Cancer
Research Center (N01-HD-2-3166), Karmanos Cancer Institute at Wayne
State University (N01-HD-3-3174), University of Pennsylvania
(NO1-HD-3-3276), and University of Southern California (N01-HD-3-3175),
and interagency agreement with Centers for Disease Control and
Prevention (Y01-HD-7022); collection of cancer incidence data in Los
Angeles County by University of Southern California supported by
California Department of Health Services as part of statewide cancer
reporting program mandated by California Health and Safety Code, Section
103885; and support for the use of Surveillance, Epidemiology, and End
Results cancer registries through contracts N01-PC-67006 (Atlanta),
N01-CN-65064 (Detroit), N01-PC-67010 (Los Angeles), and N01-CN-0532
(Seattle).
NR 36
TC 31
Z9 31
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD AUG
PY 2009
VL 18
IS 8
BP 2214
EP 2220
DI 10.1158/1055-9965.EPI-09-0301
PG 7
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA 483IW
UT WOS:000268958600011
PM 19661080
ER
PT J
AU Kelvin, EA
Edwards, S
Jedrychowski, W
Schleicher, RL
Camann, D
Tang, DL
Pereral, FP
AF Kelvin, Elizabeth A.
Edwards, Susan
Jedrychowski, Wieslaw
Schleicher, Rosemary L.
Camann, David
Tang, Deliang
Pereral, Frederica P.
TI Modulation of the Effect of Prenatal PAH Exposure on PAH-DNA Adducts in
Cord Blood by Plasma Antioxidants
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID POLYCYCLIC AROMATIC-HYDROCARBONS; GLUTATHIONE-S-TRANSFERASE; BIRTH
OUTCOMES; ALPHA-TOCOPHEROL; BETA-CAROTENE; FETAL-GROWTH; LUNG-CANCER;
DAMAGE; RISK; BIOMARKERS
AB The fetus is more susceptible than the adult to the effects of certain carcinogens, such as polycyclic aromatic hydrocarbons (PAH). Nutritional factors, including antioxidants, have been shown to have a protective effect on carcinogen-DNA adducts and cancer risk in adults. We investigated whether the effect of prenatal airborne PAH exposure, measured by personal air monitoring during pregnancy, on the level of PAH-DNA adducts in a baby's cord blood is modified by the concentration of micronutrients in maternal and cord blood. The micronutrients examined were: retinol (vitamin A), alpha-tocopherol and gamma-tocopherol (vitamin E), and carotenoids. With the use of multiple linear regression, we found a significant interaction between prenatal PAH exposure and cord blood concentration of alpha-tocopherol and carotenoids in predicting the concentration of PAH adducts in cord blood. The association between PAH exposure and PAH adducts was much stronger among those with low alpha-tocopherol (beta = 0.15; P = 0.001) and among those with low carotenoids (beta = 0.16; P < 0.001) compared with babies with high levels of these micronutrients (among those with high alpha-tocopherol: beta = 0.05; P = 0.165; among those with high carotenoids: beta = 0.06; P = 0.111). These results suggest a protective effect of micronutrients on the DNA damage and potential cancer risk associated with prenatal PAH exposure. (Cancer Epidemiol Biomarkers, Prev 2009;18(8):2262-8)
C1 [Kelvin, Elizabeth A.; Edwards, Susan; Tang, Deliang; Pereral, Frederica P.] Columbia Univ, Mailman Sch Publ Hlth, Columbia Ctr Childrens Environm Hlth, New York, NY 10032 USA.
New York State Psychiat Inst & Hosp, Data Coordinating Ctr, New York, NY 10032 USA.
[Jedrychowski, Wieslaw] Jagiellonian Univ, Coll Med, Dept Epidemiol & Prevent Med, Krakow, Poland.
[Schleicher, Rosemary L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Camann, David] SW Res Inst, Dept Analyt & Environm Chem, San Antonio, TX USA.
RP Pereral, FP (reprint author), Columbia Univ, Mailman Sch Publ Hlth, Columbia Ctr Childrens Environm Hlth, 25F Tower 3,100 Haven Ave, New York, NY 10032 USA.
EM fpp1@columbia.edu
FU National Institute of Environmental Health Sciences [5 RO1 ES10165,
02/01/00-01/31/04]; Gladys and Roland Harriman Foundation
FX Grant support: National Institute of Environmental Health Sciences grant
5 RO1 ES10165 entitled "Vulnerability of the Fetus/Infant to PAH,
PM2.5 and ETS" (02/01/00-01/31/04), and the Gladys and Roland
Harriman Foundation.
NR 29
TC 19
Z9 20
U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD AUG
PY 2009
VL 18
IS 8
BP 2262
EP 2268
DI 10.1158/1055-9965.EPI-09-0316
PG 7
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA 483IW
UT WOS:000268958600018
PM 19661084
ER
PT J
AU Fishman, JA
Strong, DM
Kuehnert, MJ
AF Fishman, Jay A.
Strong, D. Michael
Kuehnert, Matthew J.
TI Organ and tissue safety workshop 2007: advances and challenges
SO CELL AND TISSUE BANKING
LA English
DT Article
DE Transplantation; Infectious disease transmission; Tissue; Organs;
Cornea; Adverse events; Surveillance
ID TRANSPLANT RECIPIENTS; VIRUS-INFECTION; UNITED-STATES; DONOR;
TRANSMISSION; ALLOGRAFT; DISEASE; HCV
AB A workshop in June 2005 ("Preventing Organ and Tissue Allograft-Transmitted Infection: Priorities for Public Health Intervention") identified gaps in organ and tissue safety in the US. Participants developed a series of allograft safety initiatives. "The Organ and Tissue Safety Workshop 2007: Advances and Challenges" assessed progress and identified priorities for future interventions. Awareness of the challenges of allograft-associated disease transmission has increased. The Transplantation Transmission Sentinel Network will enhance communication surrounding allograft-associated disease transmission. Other patient safety initiatives have focused on adverse event reporting and microbiologic screening technologies. Despite progress, improved recognition and prevention of donor-derived transmission events is needed. This requires systems integration across the organ and tissue transplantation communities including organ procurement organizations, eye and tissue banks, and transplant infectious disease experts. Commitment of resources and improved coordination of efforts are required to develop essential tools to enhance safety for allograft recipients.
C1 [Fishman, Jay A.] Massachusetts Gen Hosp, Transplant Infect Dis Program, Boston, MA 02114 USA.
[Strong, D. Michael] Univ Washington, Sch Med, Dept Orthopaed & Sports Med, Seattle, WA USA.
[Strong, D. Michael] Univ Washington, Sch Med, Dept Surg, Seattle, WA 98195 USA.
[Kuehnert, Matthew J.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Fishman, JA (reprint author), Massachusetts Gen Hosp, Transplant Infect Dis Program, 55 Fruit St,GRJ 504, Boston, MA 02114 USA.
EM jfishman@partners.org
NR 37
TC 22
Z9 22
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1389-9333
J9 CELL TISSUE BANK
JI Cell Tissue Banking
PD AUG
PY 2009
VL 10
IS 3
BP 271
EP 280
DI 10.1007/s10561-008-9114-z
PG 10
WC Cell Biology; Engineering, Biomedical
SC Cell Biology; Engineering
GA 470TF
UT WOS:000268002600012
PM 19016348
ER
PT J
AU Hong, YL
AF Hong, Yuling
TI Burden of Cardiovascular Disease in Asia: Big Challenges and Ample
Opportunities for Action and Making a Difference
SO CLINICAL CHEMISTRY
LA English
DT Editorial Material
C1 Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA.
RP Hong, YL (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, 4770 Buford Hwy,NE MS K-47, Atlanta, GA 30341 USA.
EM yhong1@cdc.gov
NR 5
TC 9
Z9 9
U1 0
U2 0
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
J9 CLIN CHEM
JI Clin. Chem.
PD AUG
PY 2009
VL 55
IS 8
BP 1450
EP 1452
DI 10.1373/clinchem.2009.125369
PG 3
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 477ZM
UT WOS:000268557500002
PM 19498049
ER
PT J
AU Wong, D
Wild, MA
Walburger, MA
Higgins, CL
Callahan, M
Czarnecki, LA
Lawaczeck, EW
Levy, CE
Patterson, JG
Sunenshine, R
Adem, P
Paddock, CD
Zaki, SR
Petersen, JM
Schriefer, ME
Eisen, RJ
Gage, KL
Griffith, KS
Weber, IB
Spraker, TR
Mead, PS
AF Wong, David
Wild, Margaret A.
Walburger, Matthew A.
Higgins, Charles L.
Callahan, Michael
Czarnecki, Lawrence A.
Lawaczeck, Elisabeth W.
Levy, Craig E.
Patterson, J. Gage
Sunenshine, Rebecca
Adem, Patricia
Paddock, Christopher D.
Zaki, Sherif R.
Petersen, Jeannine M.
Schriefer, Martin E.
Eisen, Rebecca J.
Gage, Kenneth L.
Griffith, Kevin S.
Weber, Ingrid B.
Spraker, Terry R.
Mead, Paul S.
TI Primary Pneumonic Plague Contracted from a Mountain Lion Carcass
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID YERSINIA-PESTIS; BUBONIC PLAGUE; EXPOSURE; CATS; TRANSMISSION
AB Background. Primary pneumonic plague is a rare but often fatal form of Yersinia pestis infection that results from direct inhalation of bacteria and is potentially transmissible from person to person. We describe a case of primary pneumonic plague in a wildlife biologist who was found deceased in his residence 1 week after conducting a necropsy on a mountain lion.
Methods. To determine cause of death, a postmortem examination was conducted, and friends and colleagues were interviewed. Physical evidence was reviewed, including specimens from the mountain lion and the biologist's medical chart, camera, and computer. Human and animal tissues were submitted for testing. Persons in close contact (within 2 meters) to the biologist after he had developed symptoms were identified and offered chemoprophylaxis.
Results. The biologist conducted the necropsy in his garage without the use of personal protective equipment. Three days later, he developed fever and hemoptysis and died similar to 6 days after exposure. Gross examination showed consolidation and hemorrhagic fluid in the lungs; no buboes were noted. Plague was diagnosed presumptively by polymerase chain reaction and confirmed by culture. Tissues from the mountain lion tested positive for Y. pestis, and isolates from the biologist and mountain lion were indistinguishable by pulsed-field gel electrophoresis. Among 49 contacts who received chemoprophylaxis, none developed symptoms consistent with plague.
Conclusions. The biologist likely acquired pneumonic plague through inhalation of aerosols generated during postmortem examination of an infected mountain lion. Enhanced awareness of zoonotic diseases and appropriate use of personal protective equipment are needed for biologists and others who handle wildlife.
C1 [Wong, David] Natl Pk Serv, Off Publ Hlth, Albuquerque, NM USA.
[Walburger, Matthew A.] Natl Pk Serv, Off Publ Hlth, Flagstaff, AZ USA.
[Callahan, Michael; Czarnecki, Lawrence A.] Coconino Cty Hlth Dept, Flagstaff, AZ USA.
[Lawaczeck, Elisabeth W.; Levy, Craig E.; Patterson, J. Gage; Sunenshine, Rebecca] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA.
[Petersen, Jeannine M.; Schriefer, Martin E.; Eisen, Rebecca J.; Gage, Kenneth L.; Griffith, Kevin S.; Weber, Ingrid B.; Mead, Paul S.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA.
[Spraker, Terry R.] Colorado State Univ, Vet Diagnost Lab, Ft Collins, CO 80523 USA.
[Higgins, Charles L.] Natl Pk Serv, Off Publ Hlth, Washington, DC 20240 USA.
[Sunenshine, Rebecca] Ctr Dis Control & Prevent, Coordinating Off Terrorism Preparedness & Emergen, Atlanta, GA USA.
[Adem, Patricia; Paddock, Christopher D.; Zaki, Sherif R.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA USA.
RP Wong, D (reprint author), 801 Vassar Dr NE, Albuquerque, NM 87106 USA.
EM david_wong@nps.gov
NR 29
TC 23
Z9 25
U1 2
U2 8
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD AUG 1
PY 2009
VL 49
IS 3
BP E33
EP E38
DI 10.1086/600818
PG 6
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 468LK
UT WOS:000267819700037
PM 19555287
ER
PT J
AU Schwartz, SB
Thurman, KA
Mitchell, SL
Wolff, BJ
Winchell, JM
AF Schwartz, S. B.
Thurman, K. A.
Mitchell, S. L.
Wolff, B. J.
Winchell, J. M.
TI Genotyping of Mycoplasma pneumoniae isolates using real-time PCR and
high-resolution melt analysis
SO CLINICAL MICROBIOLOGY AND INFECTION
LA English
DT Article
DE Genomic typing; genotyping; high-resolution melt; Mycoplasma pneumoniae;
real-time PCR; subtyping
ID P1 CYTADHESIN GENE; CURVE ANALYSIS; STRAINS; POLYMORPHISM; INFECTIONS;
GENOME; JAPAN
AB Mycoplasma pneumoniae is an important respiratory pathogen, accounting for up to 25% of community-acquired pneumonia, and is a common cause of hospitalized pneumonia in otherwise healthy adults and children. Mycoplasma pneumoniae isolates can be classified into two main genomic groups (type 1 and type 2) based on sequence variation within the gene encoding the major adhesion molecule P1. Although numerous publications have described real-time PCR assays for the detection of M. pneumoniae, none has been able to discriminate the two genomic types. Here, a real-time PCR assay that can distinguish each type of M. pneumoniae utilizing high-resolution melt-curve analysis is reported. Using this method, 102 isolates obtained from patients from 1965 to the present, including those from recent outbreaks, were typed along with reference strains M129 (type 1) and FH (type 2). The results show that 55 isolates (54%) can be classified as type 1 and 47 isolates (46%) as type 2, and 100% correlation was demonstrated when compared with a standard PCR-restriction fragment length polymorphism typing procedure. Typing of isolates obtained from recent outbreaks in the USA has revealed the presence of both types. This assay provides a rapid, reliable and convenient method for typing M. pneumoniae isolates and may be useful for surveillance purposes and epidemiological investigations, and may provide insight into the biology of M. pneumoniae distribution within populations.
C1 [Schwartz, S. B.; Thurman, K. A.; Mitchell, S. L.; Wolff, B. J.; Winchell, J. M.] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30333 USA.
RP Winchell, JM (reprint author), Ctr Dis Control & Prevent, Resp Dis Branch, 1600 Clifton Rd NE,MS G-03, Atlanta, GA 30333 USA.
EM jwinchell@cdc.gov
FU government of the USA
FX This work was supported in full by the government of the USA. The
authors declare no dual or conflicting interests.
NR 24
TC 26
Z9 28
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1198-743X
EI 1469-0691
J9 CLIN MICROBIOL INFEC
JI Clin. Microbiol. Infect.
PD AUG
PY 2009
VL 15
IS 8
BP 756
EP 762
DI 10.1111/j.1469-0691.2009.02814.x
PG 7
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA 484YH
UT WOS:000269086200011
PM 19392882
ER
PT J
AU Rosen, DH
Johnson, S
Kebaabetswe, P
Thigpen, M
Smith, DK
AF Rosen, Daniel H.
Johnson, Sandra
Kebaabetswe, Poloko
Thigpen, Michael
Smith, Dawn K.
TI Process maps in clinical trial quality assurance
SO CLINICAL TRIALS
LA English
DT Article
ID PROCESS IMPROVEMENT
AB Background A process map is a diagram showing the sequential steps and decisions used to accomplish a procedure from start to finish. Process maps are a standard tool in continuous improvement efforts. They have not been used routinely in clinical trials although they are well suited to display trial processes.
Purpose We present the use of process maps as a tool to visualize and to monitor the correctness of trial work flows. We show that process maps can be used to assure that trial processes are conducted according to the SOP.
Methods We describe how a process map is made. We then derive process maps from two sources: the SOP and trial procedures as currently implemented. We compare these maps to each other, using the SOP maps as the gold standard, to check that work is done according to the written procedures.
Results Eight process maps were produced from each source. 172 differences were found between the SOP maps and the walkthrough maps. Differences included the addition of extra steps, order errors, step mistakes, and ambiguities.
Limitations These process maps focused only on clinic procedures, so interactions with other trial components were not considered. The maps were made after the trial started, which may have biased their content and use.
Conclusion Process maps are a simple tool to check if clinical trial processes are operating as designed and offer an effective means to identify and correct such divergences. Further research should focus on using process maps in the design phase of trials, analyzing the cost to benefit ratio for process maps, and linking the analysis of the process map to monitor queries to quantify the improvement gained from using this technique. Clinical Trials 2009;6:373-377.http://ctj.sagepub.com
C1 [Rosen, Daniel H.] CDC, Global AIDS Program, Atlanta, GA 30333 USA.
[Johnson, Sandra; Kebaabetswe, Poloko; Thigpen, Michael; Smith, Dawn K.] BOTUSA, CDC, Gaborone, Botswana.
RP Rosen, DH (reprint author), CDC, Global AIDS Program, CDC GAP 1600 Clifton Rd, Atlanta, GA 30333 USA.
EM drosen@psi.org
NR 18
TC 1
Z9 1
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1740-7745
J9 CLIN TRIALS
JI Clin. Trials
PD AUG
PY 2009
VL 6
IS 4
BP 373
EP 377
DI 10.1177/1740774509338429
PG 5
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA 481UD
UT WOS:000268836600008
PM 19625329
ER
PT J
AU Graham, LF
Braithwaite, K
Spikes, P
Stephens, CF
Edu, UF
AF Graham, Louis F.
Braithwaite, Kisha
Spikes, Pilgrim
Stephens, Charles F.
Edu, Ugo F.
TI Exploring the Mental Health of Black Men Who Have Sex with Men
SO COMMUNITY MENTAL HEALTH JOURNAL
LA English
DT Article; Proceedings Paper
CT 78th Annual Meeting and Conference of the
Georgia-Public-Health-Association/Our Common Welfare - MSM Health and
Wellness Summit
CY 2007
CL Atlanta, GA
SP Georgia Public Hlth Assoc
DE Depression; Anxiety; Men who have sex with men (MSM); Gay; Black
ID AFRICAN-AMERICAN MEN; BISEXUAL MEN; PERCEIVED DISCRIMINATION; IDENTITY
FORMATION; RISK BEHAVIORS; HOMOSEXUAL-MEN; UNITED-STATES; ABUSE; GAY;
DEPRESSION
AB Current research indicates that black men who have sex with men (MSM) are disproportionately burdened by depressive distress and anxiety disorders as compared to their white gay and heterosexual counterparts. This study utilizes focus groups to qualitatively explore issues surrounding the mental health status of this population in an attempt to shed light on potential influencing and determinant factors. Twenty-two self-identified black, or multi-racial including black, MSM residing in Atlanta, Georgia participated in two focus groups-11 subjects each, respectively. Categories that emerged from data analysis include: knowledge/experiences, attitudes/beliefs, societal action/behavior, identity development, relationship functionality, and mental health status. Overarching themes for each category were delineated.
C1 [Graham, Louis F.] Univ N Carolina, Dept Publ Hlth Educ, Greensboro, NC 27402 USA.
[Braithwaite, Kisha; Edu, Ugo F.] Morehouse Sch Med, Atlanta, GA 30310 USA.
[Spikes, Pilgrim] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Stephens, Charles F.] AID Atlanta, Atlanta, GA 30345 USA.
RP Graham, LF (reprint author), Univ N Carolina, Dept Publ Hlth Educ, 437 HHP Bldg, Greensboro, NC 27402 USA.
EM lfgraham@uncg.edu
NR 42
TC 7
Z9 7
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0010-3853
J9 COMMUNITY MENT HLT J
JI Community Ment. Health J.
PD AUG
PY 2009
VL 45
IS 4
BP 272
EP 284
DI 10.1007/s10597-009-9186-7
PG 13
WC Health Policy & Services; Public, Environmental & Occupational Health;
Psychiatry
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health; Psychiatry
GA 477HZ
UT WOS:000268511300007
PM 19291399
ER
PT J
AU Saydah, S
Tao, M
Imperatore, G
Gregg, E
AF Saydah, Sharon
Tao, Min
Imperatore, Giuseppina
Gregg, Edward
TI GHb Level and Subsequent Mortality Among Adults in the US
SO DIABETES CARE
LA English
DT Article; Proceedings Paper
CT 68th Annual Meeting of the American-Diabetes-Association
CY JUN 06-10, 2008
CL San Francisco, CA
SP Amer Diabet Assoc
ID AMERICAN-DIABETES-ASSOCIATION; CARDIOVASCULAR-DISEASE; GLYCOSYLATED
HEMOGLOBIN; GLUCOSE; POPULATION; HYPERGLYCEMIA; METAANALYSIS; NORFOLK;
CANCER; WOMEN
AB OBJECTIVE - To examine the association of hyperglycemia, as measured by GHb, with subsequent mortality in a nationally representative sample of adults.
RESEARCH DESIGN AND METHODS - We included adults aged >= 20 years who participated in Third National Health and Nutrition Examination Survey (1988-1994) and had complete information, including baseline diabetes status by self-report and measured GHb (n = 19,025) and follow-up through the end of 2000 for mortality.
RESULTS - In the overall population, higher levels of GHb were associated with increased risk of mortality from all causes, heart disease, and cancer. After adjustment for potential risk factors, the relative hazard (RH) for adults with GHb >= 8% compared with adults with GHb <6% was 2.59 (95% CI 1.88-3.56) for all-cause mortality, 3.38 (1.98-5.77) for heart disease mortality, and 2.64 (1.17-5.97) for cancer mortality. Among a adults with diagnosed diabetes, having GHb >= 8% compared with GHb <6% was associated with higher all-cause mortality (RH 1.68, 95% Cl 7.03-2.74) and heart disease mortality (2.48, 1.09-5.64), but there was no increased risk of cancer mortality by GHb category. Among adults without diagnosed diabetes, there was no significant association of all-cause, heart disease, or cancer mortality and GHb category.
CONCLUSIONS - These results highlight the importance of GHb levels in mortality risk among a nationally representative sample of adults with and without diagnosed diabetes and indicate that higher levels are associated with increased mortality in adults with diabetes.
C1 [Saydah, Sharon; Imperatore, Giuseppina; Gregg, Edward] Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
[Tao, Min] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA.
RP Saydah, S (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
EM ssaydah@cdc.gov
NR 26
TC 37
Z9 37
U1 0
U2 1
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD AUG
PY 2009
VL 32
IS 8
BP 1440
EP 1446
DI 10.2337/dc09-0117
PG 7
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 479UX
UT WOS:000268687800017
PM 19401445
ER
PT J
AU Wu, XF
Hu, RL
Zhang, YZ
Dong, GM
Rupprecht, CE
AF Wu, Xianfu
Hu, Rongliang
Zhang, Yongzhen
Dong, Guanmu
Rupprecht, Charles E.
TI Reemerging Rabies and Lack of Systemic Surveillance in People's Republic
of China
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID MOLECULAR CHARACTERIZATION; VIRUS; DOGS; CARRIER; VACCINATION; BENEFITS;
ANTIBODY; DISEASE
AB Rabies is a reemerging disease in China. The high incidence of rabies leads to numerous concerns: a potential carrier-dog phenomenon, undocumented transmission of rabies virus from wildlife to dogs, counterfeit vaccines, vaccine mismatching, and seroconversion testing in patients after their completion of postexposure prophylaxis (PEP). These concerns are all scientifically arguable given a modern understanding of rabies. Rabies reemerges periodically in China because of high dog population density and low vaccination coverage in dogs. Mass vaccination campaigns rather than depopulation of dogs should be a long-term goal for rabies control. Seroconversion testing after vaccination is not necessary in either humans or animals. Human PEP should be initiated on the basis of diagnosis of biting animals. Reliable national systemic surveillance of rabies-related human deaths and of animal rabies prevalence is urgently needed. A laboratory diagnosis-based epidemiologic surveillance system can provide substantial information about disease transmission and effective prevention strategies.
C1 [Wu, Xianfu; Rupprecht, Charles E.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Hu, Rongliang] Acad Mil Med Sci, Changchun, Peoples R China.
[Zhang, Yongzhen] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China.
[Dong, Guanmu] Natl Inst Control Pharmaceut & Biol Prod, Beijing, Peoples R China.
RP Wu, XF (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G33, Atlanta, GA 30333 USA.
EM xaw6@cdc.gov
RI Zhang, YZ/H-8101-2013
NR 38
TC 37
Z9 45
U1 1
U2 15
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1159
EP 1164
DI 10.3201/eid1508.081426
PG 6
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100001
PM 19751575
ER
PT J
AU Sterner, RT
Meltzer, MI
Shwiff, SA
Slate, D
AF Sterner, Ray T.
Meltzer, Martin I.
Shwiff, Stephanie A.
Slate, Dennis
TI Tactics and Economics of Wildlife Oral Rabies Vaccination, Canada and
the United States
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID PUBLIC VETERINARY-MEDICINE; RACCOON RABIES; VARIANT RABIES; RED FOXES;
ELIMINATION; ONTARIO; COYOTES; PROGRAM; HEALTH; COSTS
AB Progressive elimination of rabies in wildlife has been a general strategy in Canada and the United States; common campaign tactics are trap-vaccinate-release (TVR), point infection control (PIC), and oral rabies vaccination (ORV). TVR and PIC are labor intensive and the most expensive tactics per unit area (approximate to$616/km(2) (in 2008 Can$, converted from the reported $450/km(2) in 1991 Can$] and approximate to$612/km(2) [$500/km(2) in 1999 Can$], respectively), but these tactics have proven crucial to elimination of raccoon rabies in Canada and to maintenance of ORV zones for preventing the spread of raccoon rabies in the United States. Economic assessments have shown that during rabies epizootics, costs of human postexposure prophylaxis, pet vaccination, public health, and animal control spike. Modeling studies, involving diverse assumptions, have shown that ORV programs can be cost-efficient and yield benefit:cost ratios >1.0.
C1 [Sterner, Ray T.] USDA APHIS WS, Natl Wildlife Res Ctr, Ft Collins, CO 80521 USA.
[Meltzer, Martin I.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Slate, Dennis] USDA, Concord, NH USA.
RP Sterner, RT (reprint author), USDA APHIS WS, Natl Wildlife Res Ctr, 4101 Laporte Ave, Ft Collins, CO 80521 USA.
EM ray.t.sterner@aphis.usda.gov
NR 37
TC 30
Z9 32
U1 1
U2 24
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1176
EP 1184
DI 10.3201/eid1508.081061
PG 9
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100004
PM 19757549
ER
PT J
AU Datta, K
Bartlett, KH
Baer, R
Byrnes, E
Galanis, E
Heitman, J
Hoang, L
Leslie, MJ
MacDougall, L
Magill, SS
Morshed, MG
Marr, KA
AF Datta, Kausik
Bartlett, Karen H.
Baer, Rebecca
Byrnes, Edmond
Galanis, Eleni
Heitman, Joseph
Hoang, Linda
Leslie, Mira J.
MacDougall, Laura
Magill, Shelley S.
Morshed, Muhammad G.
Marr, Kieren A.
CA Cryptococcus Gattii Working Grp
TI Spread of Cryptococcus gattii into Pacific Northwest Region of the
United States
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID VANCOUVER-ISLAND OUTBREAK; BRITISH-COLUMBIA; SEROTYPE-C; NEOFORMANS;
INFECTION; EPIDEMIOLOGY; CANADA; AIDS; RECOMBINATION; ASSOCIATION
AB Cryptococcus gattii has emerged as a human and animal pathogen in the Pacific Northwest. First recognized on Vancouver Island, British Columbia, Canada, it now involves mainland British Columbia, and Washington and Oregon in the United States. In Canada, the incidence of disease has been one of the highest worldwide. In the United States, lack of cryptococcal species identification and case surveillance limit our knowledge of C. gattii epidemiology. Infections in the Pacific Northwest are caused by multiple genotypes, but the major strain is genetically novel and may have emerged recently in association with unique mating or environmental changes. C. gattii disease affects immunocompromised and immunocompetent persons, causing substantial illness and death. Successful management requires an aggressive medical and surgical approach and consideration of potentially variable antifungal drug susceptibilities. We summarize the study results of a group of investigators and review current knowledge with the goal of increasing awareness and highlighting areas where further knowledge is required.
C1 [Marr, Kieren A.] Johns Hopkins Univ, Sch Med, Div Infect Dis, Baltimore, MD 21205 USA.
[Bartlett, Karen H.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
[Baer, Rebecca] Washington State Dept Hlth, Shoreline, WA USA.
[Byrnes, Edmond; Heitman, Joseph] Duke Univ, Med Ctr, Durham, NC USA.
[Galanis, Eleni; Hoang, Linda; MacDougall, Laura; Morshed, Muhammad G.] British Columbia Ctr Dis Control, Vancouver, BC, Canada.
[Leslie, Mira J.] British Columbia Minist Agr & Lands, Abbotsford, BC, Canada.
[Magill, Shelley S.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Marr, KA (reprint author), Johns Hopkins Univ, Sch Med, Div Infect Dis, 720 Rutland Ave,Ross Res Bldg,Rm 1064, Baltimore, MD 21205 USA.
EM kmarr4@jhmi.edu
RI Kidd, Sarah/A-1731-2009; Datta, Kausik/A-2879-2016
OI Kidd, Sarah/0000-0002-5957-4178; Datta, Kausik/0000-0001-8666-143X
NR 40
TC 120
Z9 125
U1 2
U2 7
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1185
EP 1191
DI 10.3201/eid1508.081384
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100005
PM 19757550
ER
PT J
AU Tao, XY
Tang, Q
Li, H
Mo, ZJ
Zhang, H
Wang, DM
Zhang, Q
Song, M
Velasco-Villa, A
Wu, XF
Rupprecht, CE
Liang, GD
AF Tao, Xiao-Yan
Tang, Qing
Li, Hao
Mo, Zhao-Jun
Zhang, Hong
Wang, Ding-Ming
Zhang, Qiang
Song, Miao
Velasco-Villa, Andres
Wu, Xianfu
Rupprecht, Charles E.
Liang, Guo-Dong
TI Molecular Epidemiology of Rabies in Southern People's Republic of China
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID SEQUENCE ALIGNMENT; VIRUS; DOGS; THAILAND; QUALITY; GENE
AB In recent years, the number of human rabies cases in the People's Republic of China has increased during severe epidemics in 3 southern provinces (Guizhou, Guangxi, and Hunan). To analyze the causes of the high incidence of human rabies in this region, during 2005-2007, we collected 2,887 brain specimens from apparently healthy domestic dogs used for meat consumption in restaurants, 4 specimens from suspected rabid dogs, and 3 from humans with rabies in the 3 provinces. Partial nucleoprotein gene sequences were obtained from rabies-positive specimens. Phylogenetic relationships and distribution of viruses were determined. We infer that the spread of rabies viruses from high-incidence regions, particularly by long-distance movement or transprovincial translocation of dogs caused by human-related activities, may be 1 cause of the recent massive human rabies epidemics in southern China.
C1 [Tang, Qing] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, State Key Lab Mol Virol & Genet Engn, Beijing 100052, Peoples R China.
[Mo, Zhao-Jun] Guangxi Ctr Dis Control & Prevent, Nanning, Peoples R China.
[Zhang, Hong] Hunan Ctr Dis Control & Prevent, Changsha, Hunan, Peoples R China.
[Wang, Ding-Ming] Guizhou Ctr Dis Control & Prevent, Guiyang, Peoples R China.
[Velasco-Villa, Andres; Wu, Xianfu; Rupprecht, Charles E.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Tang, Q (reprint author), Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, State Key Lab Mol Virol & Genet Engn, 100 Ying Xin St, Beijing 100052, Peoples R China.
EM qtang04@sina.com
FU National 863 Program [SQ2006AA02Z112882]; Key Project of National Nature
Science Foundation of China [30630049]
FX We thank Kaijiao ZhOLI, Yi Tan, Jinzhu Zhou, Chun Yu, YLmzhi Liu, and
Defang Dai for specimen collection and diagnosis; and Michael Niezgoda
and Lilian Orciari for rabies training and technology transfer to
China.; This study was supported by National 863 Program (grant no.
SQ2006AA02Z112882) and the Key Project of National Nature Science
Foundation of China (grant no. 30630049).
NR 34
TC 20
Z9 31
U1 1
U2 3
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
EI 1080-6059
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1192
EP 1198
DI 10.3201/eid1508.081551
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100006
PM 19751579
ER
PT J
AU Luby, SP
Hossain, MJ
Gurley, ES
Ahmed, BN
Banu, S
Khan, SU
Homaira, N
Rota, PA
Rollin, PE
Comer, JA
Kenah, E
Ksiazek, TG
Rahman, M
AF Luby, Stephen P.
Hossain, M. Jahangir
Gurley, Emily S.
Ahmed, Be-Nazir
Banu, Shakila
Khan, Salah Uddin
Homaira, Nusrat
Rota, Paul A.
Rollin, Pierre E.
Comer, James A.
Kenah, Eben
Ksiazek, Thomas G.
Rahman, Mahmudur
TI Recurrent Zoonotic Transmission of Nipah Virus into Humans, Bangladesh,
2001-2007
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID TO-PERSON TRANSMISSION; NOSOCOMIAL TRANSMISSIBILITY; HENIPAVIRUS
INFECTION; PTEROPUS-GIGANTEUS; FLYING-FOXES; RISK-FACTORS; FRUIT BATS;
ENCEPHALITIS; OUTBREAK; MALAYSIA
AB Human Nipah outbreaks recur in a specific region and time of year in Bangladesh. Fruit bats are the reservoir host for Nipah virus. We identified 23 introductions of Nipah virus into human populations in central and northwestern Bangladesh from 2001 through 2007. Ten introductions affected multiple persons (median 10). Illness onset occurred from December through May but not every year. We identified 122 cases of human Nipah infection. The mean age of case-patients was 27 years; 87 (71%) died. In 62 (51%) Nipah virus-infected patients, illness developed 5-15 days after close contact with another Nipah case-patient. Nine (7%) Nipah case-patients transmitted virus to others. Nipah case-patients who had difficulty breathing were more likely than those without respiratory difficulty to transmit Nipah (12% vs. 0%, p = 0.03). Although a small minority of infected patients transmit Nipah virus, more than half of identified cases result from person-to-person transmission. Interventions to prevent virus transmission from bats to humans and from person to person are needed.
C1 [Luby, Stephen P.] ICDDR B, Programme Infect Dis & Vaccine Sci, Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh.
[Ahmed, Be-Nazir; Homaira, Nusrat; Rahman, Mahmudur] Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh.
[Rota, Paul A.; Rollin, Pierre E.; Comer, James A.; Ksiazek, Thomas G.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Kenah, Eben] Univ Washington, Sch Publ Hlth & Community Med, Seattle, WA 98195 USA.
RP Luby, SP (reprint author), ICDDR B, Programme Infect Dis & Vaccine Sci, Int Ctr Diarrhoeal Dis Res, GPO Box 128, Dhaka 1000, Bangladesh.
EM sluby@icddrb.org
RI Gurley, Emily/B-7903-2010
OI Gurley, Emily/0000-0002-8648-9403
FU CDC; US National Institutes of Health Division of Microbiology and
Infectious Diseases; International Collaborations in Infectious Disease
Opportunity Pool; Government of Bangladesh; National Institute of
General Medical Sciences [F32GM085945]
FX The authors are grateful to the many contributors to Nipah virus
outbreak investigations in Bangladesh since 2001, both those recognized
as coauthors in earlier publications and the many field workers,
laboratory technicians, and support staff whose willingness to promptly
and thoroughly investigate outbreaks of this dangerous pathogen has been
essential to Our improved understanding of Nipah virus in Bangladesh.;
This work was funded by CDC, the US National Institutes of Health
Division of Microbiology and Infectious Diseases, International
Collaborations in Infectious Disease Opportunity Pool, and the
Government of Bangladesh through The Improved Health for the Poor:
Health, Nutrition and Population Research Project. E.K.'s contribution
to this manuscript was supported by National Institute of General
Medical Sciences grant F32GM085945. The ICDDR,B, acknowledges with
gratitude the commitment of CDC, the National Institutes of Health, and
the government of Bangladesh to the Centre's research efforts.; Dr Luby
is a medical epidemiologist whose work has focused on communicable
disease epidemiology and low-cost prevention strategies in low-income
countries. He is currently detailed from CDC to the ICDDR,B, where he
heads the program on Infectious Diseases and Vaccine Sciences.
NR 37
TC 127
Z9 129
U1 0
U2 37
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
EI 1080-6059
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1229
EP 1235
DI 10.3201/eid1508.081237
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100011
PM 19751584
ER
PT J
AU Verani, JR
Lorick, SA
Yoder, JS
Beach, MJ
Braden, CR
Roberts, JM
Conover, CS
Chen, S
McConnell, KA
Chang, DC
Park, BJ
Jones, DB
Visvesvara, GS
Roy, SL
AF Verani, Jennifer R.
Lorick, Suchita A.
Yoder, Jonathan S.
Beach, Michael J.
Braden, Christopher R.
Roberts, Jacquelin M.
Conover, Craig S.
Chen, Sue
McConnell, Kateesha A.
Chang, Douglas C.
Park, Benjamin J.
Jones, Dan B.
Visvesvara, Govinda S.
Roy, Sharon L.
CA Acanthamoeba Keratitis Invest Team
TI National Outbreak of Acanthamoeba Keratitis Associated with Use of a
Contact Lens Solution, United States
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID WATER; IDENTIFICATION; INFECTION; DIAGNOSIS; STRAINS; EYE; PCR
C1 [Verani, Jennifer R.; Lorick, Suchita A.; Yoder, Jonathan S.; Beach, Michael J.; Braden, Christopher R.; Roberts, Jacquelin M.; Chang, Douglas C.; Park, Benjamin J.; Visvesvara, Govinda S.; Roy, Sharon L.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Conover, Craig S.] Illinois Dept Publ Hlth, Chicago, IL USA.
[Chen, Sue] Calif Dept Publ Hlth, Sacramento, CA USA.
[McConnell, Kateesha A.] Florida Dept Hlth, Tallahassee, FL USA.
[Jones, Dan B.] Baylor Coll Med, Houston, TX 77030 USA.
RP Verani, JR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop C23, Atlanta, GA 30333 USA.
EM jverani@cdc.gov
NR 36
TC 78
Z9 80
U1 1
U2 8
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1236
EP 1242
DI 10.3201/eid1508.090225
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100012
PM 19751585
ER
PT J
AU Stephenson, I
Heath, A
Major, D
Newman, RW
Hoschler, K
Junzi, W
Katz, JM
Weir, JP
Zambon, MC
Wood, JM
AF Stephenson, Iain
Heath, Alan
Major, Diane
Newman, Robert W.
Hoschler, Katja
Junzi, Wang
Katz, Jacqueline M.
Weir, Jerry P.
Zambon, Maria C.
Wood, John M.
TI Reproducibility of Serologic Assays for Influenza Virus A (H5N1)
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID MF59-ADJUVANTED INFLUENZA; HUMAN SERA; ANTIBODY; VACCINE
AB Hemagglutination-inhibition (HI) and neutralization are used to evaluate vaccines against influenza virus A (H5N1); however, poor standardization leads to interlaboratory variation of results. A candidate antibody standard (07/150) was prepared from pooled plasma of persons given clade 1 A/Vietnam/1194/2004 vaccine. To test human and sheep antiserum, 15 laboratories used HI and neutralization and reassortant A/Vietnam/1194/2004, A/turkey/Turkey/1/2005 (clade 2.2), and A/Anhui/1/2005 (clade 2.3.4) viruses. Inter-laboratory variation was observed for both assays, but when titers were expressed relative to 07/150, overall percentage geometric coefficient of variation for A/Vietnam/1194/2004 was reduced from 125% to 61% for HI and from 183% to 81% for neutralization. Lack of reduced variability to clade 2 antigens suggested the need for clade-specific standards. Sheep antiserum as a standard did not reliably reduce variability. The World Health Organization has established 07/150 as an international standard for antibody to clade 1 subtype H5 and has an assigned potency of 1,000 IU/ampoule.
C1 [Stephenson, Iain] Univ Leicester, Leicester, Leics, England.
[Heath, Alan; Major, Diane; Newman, Robert W.; Wood, John M.] Natl Inst Biol Stand & Controls, Potters Bar EN6 3QG, Herts, England.
[Hoschler, Katja; Zambon, Maria C.] Hlth Protect Agcy, Colindale, England.
[Katz, Jacqueline M.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Weir, Jerry P.] US FDA, Rockville, MD 20857 USA.
[Junzi, Wang] Natl Inst Control Pharmaceut & Biol Prod, Beijing, Peoples R China.
RP Stephenson, I (reprint author), Leicester Royal Infirm, Infect Dis Unit, Leicester LE1 5WW, Leics, England.
EM iain.stephenson@uhl-tr.nhs.uk
FU Nobilon; NexBio; CSL Biotherapies; Sanofi-Pasteur; Baxter; Novartis
FX Dr Stephenson is a senior lecturer in infectious diseases at the
University of Leicester. He has research interests in the extent of
respiratory virus infections and their control with vaccines and
antiviral drugs.
NR 20
TC 21
Z9 21
U1 0
U2 2
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1250
EP 1259
DI 10.3201/eid1508.081754
PG 10
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100014
PM 19751587
ER
PT J
AU Ortiz, JR
Sotomayor, V
Uez, OC
Oliva, O
Bettels, D
McCarron, M
Bresee, JS
Mounts, AW
AF Ortiz, Justin R.
Sotomayor, Viviana
Uez, Osvaldo C.
Oliva, Otavio
Bettels, Deborah
McCarron, Margaret
Bresee, Joseph S.
Mounts, Anthony W.
TI Strategy to Enhance Influenza Surveillance Worldwide
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID PANDEMIC INFLUENZA; PREPAREDNESS; HOSPITALIZATIONS; DIAGNOSIS; CHILDREN;
AFRICA; DEATHS; REGION; PLANS
AB The emergence of a novel strain of influenza virus A (H1N1) in April 2009 focused attention on influenza surveillance capabilities worldwide. In consultations before the 2009 outbreak of influenza subtype H1N1, the World Health Organization had concluded that the world was unprepared to respond to an influenza pandemic, due in part to inadequate global surveillance and response capacity. We describe a sentinel surveillance system that could enhance the quality of influenza epidemiologic and laboratory data and strengthen a country's capacity for seasonal, novel, and pandemic influenza detection and prevention. Such a system would 1) provide data for a better understanding of the epidemiology and extent of seasonal influenza, 2) provide a platform for the study of other acute febrile respiratory illnesses, 3) provide virus isolates for the development of vaccines, 4) inform local pandemic planning and vaccine policy, 5) monitor influenza epidemics and pandemics, and 6) provide infrastructure for an early warning system for outbreaks of new virus subtypes.
C1 [Ortiz, Justin R.] Univ Washington, Seattle, WA 98195 USA.
[Sotomayor, Viviana] Minist Salud, Santiago, Chile.
[Uez, Osvaldo C.] Inst Nacl Epidemiol, Mar Del Plata, Argentina.
[Oliva, Otavio] Pan Amer Hlth Org, Washington, DC USA.
[Bettels, Deborah; McCarron, Margaret; Bresee, Joseph S.; Mounts, Anthony W.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Mounts, AW (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,Mailstop A32, Atlanta, GA 30333 USA.
EM apm8@cdc.gov
FU University of Washington
FX Dr Ortiz is a research fellow at the University of Washington and PATH
(Program for Appropriate Technology and Health). His research interest
is the clinical epidemiology of respiratory infections found in tropical
regions.
NR 29
TC 60
Z9 67
U1 0
U2 2
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1271
EP 1278
DI 10.3201/eid1508.081422
PG 8
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100017
PM 19751590
ER
PT J
AU Kothari, NJ
Morin, CA
Glennen, A
Jackson, D
Harper, J
Schrag, SJ
Lynfield, R
AF Kothari, Neelay J.
Morin, Craig A.
Glennen, Anita
Jackson, Delois
Harper, Jane
Schrag, Stephanie J.
Lynfield, Ruth
TI Invasive Group B Streptococcal Disease in the Elderly, Minnesota, USA,
2003-2007
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID REDUCED PENICILLIN SUSCEPTIBILITY; MOLECULAR CHARACTERIZATION;
NONPREGNANT ADULTS
AB In Minnesota, incidence of invasive group B streptococcal disease was 3 times greater in older adults in long-term care facilities than in older adults in community settings (67.7/100,000 vs. 21.4/100,000) during 2003-2007. The overall case-fatality rate was 6.8%, and concurrent conditions were common among both groups.
C1 [Kothari, Neelay J.; Morin, Craig A.; Glennen, Anita; Harper, Jane; Lynfield, Ruth] Minnesota Dept Hlth, St Paul, MN USA.
[Kothari, Neelay J.] Univ Minnesota, Minneapolis, MN USA.
[Jackson, Delois; Schrag, Stephanie J.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Kothari, NJ (reprint author), 625 Robert St N,POB 64975, St Paul, MN 55164 USA.
EM koth0036@umn.edu
FU University of Minnesota
FX Dr Kothari recently completed an Infectious Diseases Fellowship at the
University of Minnesota. His research interests include the epidemiology
of infections among residents of longterm care facilities, with a focus
on antimicrobial drug resistance and appropriate use of antimicrobial
drugs in this population.
NR 15
TC 10
Z9 10
U1 0
U2 0
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1279
EP 1281
DI 10.3201/eid1508.081381
PG 3
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100018
PM 19751591
ER
PT J
AU Hunsperger, EA
McElroy, KL
Bessoff, K
Colon, C
Barrera, R
Munoz-Jordan, JL
AF Hunsperger, Elizabeth A.
McElroy, Kate L.
Bessoff, Kovi
Colon, Candimar
Barrera, Roberto
Munoz-Jordan, Jorge L.
TI West Nile Virus from Blood Donors, Vertebrates, and Mosquitoes, Puerto
Rico, 2007
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID TRANSMISSION; ASSAY
AB West Nile virus (WNV) was isolated from a human blood donor, a dead falcon, and mosquitoes in Puerto Rico in 2007. Phylogenetic analysis of the 4 isolates suggests a recent introduction of lineage I WNV that is closely related to WNV currently circulating in North America.
C1 [Hunsperger, Elizabeth A.] Ctr Dis Control & Prevent, Serol Diagnost & Viral Pathogenesis Res Lab, San Juan, PR 00920 USA.
RP Hunsperger, EA (reprint author), Ctr Dis Control & Prevent, Serol Diagnost & Viral Pathogenesis Res Lab, 1324 Calle Canada, San Juan, PR 00920 USA.
EM enh4@cdc.gov
NR 15
TC 13
Z9 14
U1 0
U2 1
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1298
EP 1300
DI 10.3201/eid1508.090333
PG 3
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100024
PM 19751597
ER
PT J
AU Salmon-Mulanovich, G
Vasquez, A
Albujar, C
Guevara, C
Laguna-Torres, VA
Salazar, M
Zamalloa, H
Caceres, M
Gomez-Benavides, J
Pacheco, V
Contreras, C
Kochel, T
Niezgoda, M
Jackson, FR
Velasco-Villa, A
Rupprecht, C
Montgomery, JM
AF Salmon-Mulanovich, Gabriela
Vasquez, Alicia
Albujar, Christian
Guevara, Carolina
Alberto Laguna-Torres, V.
Salazar, Milagros
Zamalloa, Hernan
Caceres, Marcia
Gomez-Benavides, Jorge
Pacheco, Victor
Contreras, Carlos
Kochel, Tadeusz
Niezgoda, Michael
Jackson, Felix R.
Velasco-Villa, Andres
Rupprecht, Charles
Montgomery, Joel M.
TI Human Rabies and Rabies in Vampire and Nonvampire Bat Species,
Southeastern Peru, 2007
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID TADARIDA-BRASILIENSIS-MEXICANA; VIRUS; PREVALENCE; ANTIBODY; ANDES;
CHILE
AB After a human rabies outbreak in southeastern Peru, we collected bats to estimate the prevalence of rabies in various species. Among 165 bats from 6 genera and 10 species, 10.3% were antibody positive; antibody prevalence was similar in vampire and nonvampire bats. Thus, nonvampire bats may also be a source for human rabies in Peru.
C1 [Salmon-Mulanovich, Gabriela; Albujar, Christian; Guevara, Carolina; Alberto Laguna-Torres, V.; Kochel, Tadeusz; Montgomery, Joel M.] US Naval, Med Res Ctr Detachment, Lima, Peru.
[Salmon-Mulanovich, Gabriela] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Vasquez, Alicia; Pacheco, Victor] Univ Nacl Mayor San Marcos, Lima, Peru.
[Salazar, Milagros] Univ Texas Med Branch, Galveston, TX USA.
[Zamalloa, Hernan] Inst Nacl Salud, Lima, Peru.
[Caceres, Marcia; Contreras, Carlos] Direcc Salud Madre Dios, Puerto Maldonado, Peru.
[Gomez-Benavides, Jorge] Direcc Gen Epidemiol, Lima, Peru.
[Niezgoda, Michael; Jackson, Felix R.; Velasco-Villa, Andres; Rupprecht, Charles] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Montgomery, JM (reprint author), US Naval, Emerging Infect Program, Med Res Ctr Detachment, 3230 Lima Pl, Washington, DC 20521 USA.
EM joel.montgomery@med.navy.mil
OI Pacheco, Victor/0000-0002-1005-135X
FU US Department of Defense Global Emerging Infections Surveillance and
Response System [847705 82000 25GB B0016]
FX This work was funded by US Department of Defense Global Emerging
Infections Surveillance and Response System and supported by work unit
no. 847705 82000 25GB B0016.
NR 14
TC 15
Z9 16
U1 0
U2 6
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1308
EP 1310
DI 10.3201/eid1508.081522
PG 3
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100027
PM 19751600
ER
PT J
AU Brooks, WA
Alamgir, ASM
Sultana, R
Islam, MS
Rahman, M
Fry, A
Shu, B
Lindstrom, S
Nahar, K
Goswami, D
Haider, MS
Nahar, S
Butler, E
Hancock, K
Donis, RO
Davis, CT
Zaman, RU
Luby, SP
Uyeki, TM
Rahman, M
AF Brooks, W. Abdullah
Alamgir, A. S. M.
Sultana, Rebecca
Islam, M. Saiful
Rahman, Mustafizur
Fry, Alicia
Shu, Bo
Lindstrom, Stephen
Nahar, Kamrun
Goswami, Doli
Haider, M. Sabbir
Nahar, Sharifun
Butler, Ebonee
Hancock, Kathy
Donis, Ruben O.
Davis, Charles T.
Zaman, Rashid Uz
Luby, Stephen P.
Uyeki, Timothy M.
Rahman, Mahmudur
TI Avian Influenza Virus A (H5N1), Detected through Routine Surveillance,
in Child, Bangladesh
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID TOXIGENIC CORYNEBACTERIUM-ULCERANS; DIPHTHERIA; STRAINS; HUMANS
AB We identified avian influenza virus A (H5N1) infection in a child in Bangladesh in 2008 by routine influenza surveillance. The virus was of the same clade and phylogenetic subgroup as that circulating among poultry during the period. This case illustrates the value of routine surveillance for detection of novel influenza virus.
C1 [Brooks, W. Abdullah; Sultana, Rebecca; Islam, M. Saiful; Rahman, Mustafizur; Nahar, Kamrun; Goswami, Doli; Nahar, Sharifun; Zaman, Rashid Uz; Luby, Stephen P.] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh.
[Brooks, W. Abdullah] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Alamgir, A. S. M.; Haider, M. Sabbir; Rahman, Mahmudur] Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh.
[Fry, Alicia; Shu, Bo; Lindstrom, Stephen; Butler, Ebonee; Hancock, Kathy; Donis, Ruben O.; Davis, Charles T.; Luby, Stephen P.; Uyeki, Timothy M.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Brooks, WA (reprint author), Int Ctr Diarrhoeal Dis Res, GPO Box 128, Dhaka 1000, Bangladesh.
RI rahman, mustafizur/E-6918-2010
FU Bavarian State Ministry of the Environment and Public Health
FX The study was partly supported by a grant from the Bavarian State
Ministry of the Environment and Public Health.
NR 10
TC 24
Z9 27
U1 0
U2 1
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1311
EP 1313
DI 10.3201/eid1508.090283
PG 3
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100028
PM 19751601
ER
PT J
AU Mahy, BWJ
AF Mahy, Brian W. J.
TI George Martin Baer (1936-2009) IN MEMORIAM
SO EMERGING INFECTIOUS DISEASES
LA English
DT Biographical-Item
C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Mahy, BWJ (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D61, Atlanta, GA 30333 USA.
EM bxm1@cdc.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1335
EP 1335
DI 10.3201/eid1508.090897
PG 1
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100044
ER
PT J
AU Potter, P
AF Potter, Polyxeni
TI For the world does not yet censure Those who tread the paths of dreams
SO EMERGING INFECTIOUS DISEASES
LA English
DT Editorial Material
C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Potter, P (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D61, Atlanta, GA 30333 USA.
EM PMP1@cdc.gov
NR 10
TC 0
Z9 0
U1 0
U2 0
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD AUG
PY 2009
VL 15
IS 8
BP 1336
EP 1337
DI 10.3201/eid1508.000000
PG 2
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 481NT
UT WOS:000268819100045
PM 19751617
ER
PT J
AU Guo, XQ
Verkler, TL
Mei, N
Richter, PA
Polzin, GM
Moore, MM
AF Guo, X. Q.
Verkler, T. L.
Mei, N.
Richter, P. A.
Polzin, G. M.
Moore, M. M.
TI Relative Mutagenicity of Cigarette Smoke Condensates in Mouse Lymphoma
Cells
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
CT 40th Annual Meeting of the Environment-Mutagen-Society
CY OCT 24-28, 2009
CL St Louis, MO
SP Environm Mutagen Soc
C1 [Guo, X. Q.; Verkler, T. L.; Mei, N.; Moore, M. M.] Natl Ctr Toxicol Res, Jefferson, AR 72079 USA.
[Richter, P. A.] Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
[Polzin, G. M.] Natl Ctr Environm Hlth, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0893-6692
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD AUG
PY 2009
VL 50
IS 7
BP 586
EP 586
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA 484LM
UT WOS:000269046400197
ER
PT J
AU Hoagland, P
Jin, D
Polansky, LY
Kirkpatrick, B
Kirkpatrick, G
Fleming, LE
Reich, A
Watkins, SM
Ullmann, SG
Backer, LC
AF Hoagland, Porter
Jin, Di
Polansky, Lara Y.
Kirkpatrick, Barbara
Kirkpatrick, Gary
Fleming, Lora E.
Reich, Andrew
Watkins, Sharon M.
Ullmann, Steven G.
Backer, Lorraine C.
TI The Costs of Respiratory Illnesses Arising from Florida Gulf Coast
Karenia brevis Blooms
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE cost of illness; emergency department (ED); harmful algal bloom (HAB);
economic impact; natural hazard
ID TIDE TOXINS BREVETOXINS; RED-TIDE; MARINE AEROSOL; HUMAN EXPOSURE;
ASTHMA
AB BACKGROUND: Algal blooms of Karenia brevis, a harmful marine algae, occur almost annually off the west coast of Florida. At high concentrations, K brevis blooms can cause harm through the release of potent toxins, known as brevetoxins, to the atmosphere. Epidemiologic studies suggest that aerosolized brevetoxins are linked to respiratory illnesses in humans.
OBJECTIVES: We hypothesized a relationship between K brevis blooms and respiratory illness visits to hospital emergency departments (EDs) while controlling for environmental factors, disease, and tourism. We sought to use this relationship to estimate the costs of illness associated with aerosolized brevetoxins.
METHODS: We developed a statistical exposure-response model to express hypotheses about the relationship between respiratory illnesses and bloom events. We estimated the model with data on ED visits, K brevis cell densities, and measures of pollen, pollutants, respiratory disease, and intra-annual population changes.
RESULTS: We found that lagged K brevis cell counts, low air temperatures, influenza outbreaks, high pollen counts, and tourist visits helped explain the number of respiratory-specific ED diagnoses. The capitalized estimated marginal costs of illness for ED respiratory illnesses associated with K brevis blooms in Sarasota County, Florida, alone ranged from $0.5 to $4 million, depending on bloom severity.
CONCLUSIONS: Blooms of K brevis lead to significant economic impacts. The costs of illness of ED visits are a conservative estimate of the total economic impacts. It will become increasingly necessary to understand the scale of the economic losses associated with K brevis blooms to make rational choices about appropriate mitigation.
C1 [Hoagland, Porter; Jin, Di; Polansky, Lara Y.] Woods Hole Oceanog Inst, Marine Policy Ctr, Woods Hole, MA 02543 USA.
[Kirkpatrick, Barbara; Kirkpatrick, Gary] Mote Marine Lab, Environm Hlth Program, Sarasota, FL 34236 USA.
[Fleming, Lora E.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
[Fleming, Lora E.] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, Miami, FL 33136 USA.
[Reich, Andrew; Watkins, Sharon M.] Florida Dept Hlth, Bur Community Environm Hlth, Aquat Toxins Program, Tallahassee, FL USA.
[Ullmann, Steven G.] Univ Miami, Dept Management, Miami, FL USA.
[Backer, Lorraine C.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
RP Hoagland, P (reprint author), Woods Hole Oceanog Inst, Marine Policy Ctr, MS 41, Woods Hole, MA 02543 USA.
EM phoagland@whoi.edu
OI Hoagland, Porter/0000-0003-0744-4184
FU Florida Fish & Wildlife Conservation Commission [07182]; Departments of
Environmental protection and Health; U.S. Centers for Disease Control
and Prevention; Center for Oceans and Human Health at the Woods Hole
Oceanographic Institution, National Science Foundation (NSF)
[OCE-0430724]; National Institute of Environmental Health Sciences
(NIEHS) [P50 ES0127421, PO1 ES 10594]; Ocean and Human Health Center at
the University of Miami Rosenstiel School [NSF 0CE0432368, NIEHS 1 P50
ES12736]
FX This research was sponsored by the Florida Fish & Wildlife Conservation
Commission (07182) and the Departments of Environmental protection and
Health; the U.S. Centers for Disease Control and Prevention; the Center
for Oceans and Human Health at the Woods Hole Oceanographic Institution
[National Science Foundation (NSF) OCE-0430724; National Institute of
Environmental Health Sciences (NIEHS) P50 ES0127421; the Ocean and Human
Health Center at the University of Miami Rosenstiel School (NSF
0CE0432368; NIEHS 1 P50 ES12736); and the NIEHS (PO1 ES 10594).
NR 35
TC 32
Z9 32
U1 5
U2 27
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD AUG
PY 2009
VL 117
IS 8
BP 1239
EP 1243
DI 10.1289/ehp.0900645
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 478DD
UT WOS:000268567100027
PM 19672403
ER
PT J
AU Wang, RY
Jain, RB
Wolkin, AF
Rubin, CH
Needham, LL
AF Wang, Richard Y.
Jain, Ram B.
Wolkin, Amy F.
Rubin, Carol H.
Needham, Larry L.
TI Serum Concentrations of Selected Persistent Organic Pollutants in a
Sample of Pregnant Females and Changes in Their Concentrations during
Gestation
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE dioxin; females; organochlorine pesticides; PCB; persistent organic
pollutants; pregnant; serum concentrations
ID POLYCHLORINATED-BIPHENYLS PCBS; LOW-DENSITY-LIPOPROTEIN; HUMAN BLOOD;
ORGANOCHLORINE PESTICIDES; ENVIRONMENTAL EXPOSURE; FISH CONSUMPTION;
ADIPOSE-TISSUE; HUMAN-MILK; WOMEN; DIOXINS
AB OBJECTIVES: In this study we evaluated the concentrations of selected persistent organic pollutants in a sample of first-time pregnant females residing in the United States and assessed differences in these concentrations in all pregnant females during gestation.
METHODS: We reviewed demographic and laboratory data for pregnant females participating in the National Health and Nutrition Examination Survey, including concentrations of 25 polychlorinated biphenyls (PCBs), 6 polychlorinated dibenzo-p-dioxins (PCDDs), 9 polychlorinated dibenzofurans (PCDFs), and 9 organochlorine pesticides. We report serum concentrations for first-time pregnant females (2001-2002; n = 49) and evaluate these concentrations in all pregnant females by trimester (1999-2002; n = 203) using a cross-sectional analysis.
RESULTS: The chemicals with >= 60% detection included PCBs (congeners 126, 138/158, 153, 180), PCDDs/PCDFs [1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (1234678HpCDD), 1,2,3,6,7,8-hexachlorodibenzo-p-dioxin (123678HxCDD), 1,2,3,4,6,7,8-heptachlorodibenzofuran (1234678HpCDF), 1,1'-(2,2-dichloroethenylidene)-bis(4-chlorobenzene) (p,p'-DDE)], and transnonachlor. The geometric mean concentration (95% confidence intervals) for 1234678HpCDD was 15.9 pg/g lipid (5.0-50.6 pg/g); for 123678HxCDD, 9.7 pg/g (5.5-17.1 pg/g); and for 1234678HpCDF, 5.4 pg/g (3.3-8.7 pg/g). The differences in concentrations of these chemicals by trimester were better accounted for with the use of lipid-adjusted units than with whole-weight units; however, the increase in the third-trimester concentration was greater for PCDDs/PCDFs (123678HxCDD, 1234678HpCDF) than for the highest concentration of indicator PCBs (138/158, 153, 180), even after adjusting for potential confounders.
CONCLUSION: The concentrations of these persistent organic pollutants in a sample of first-time pregnant females living in the United States suggest a decline in exposures to these chemicals since their ban or restricted use and emission. The redistribution of body burden for these and other persistent organic pollutants during pregnancy needs to be more carefully defined to improve the assessment of fetal exposure to them based on maternal serum concentrations. Additional studies are needed to further the understanding of the potential health consequences to the fetus from persistent organic pollutants.
C1 [Wang, Richard Y.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Rubin, Carol H.] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30341 USA.
RP Wang, RY (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Hwy NE,Mail Stop F-17, Atlanta, GA 30341 USA.
EM rywang@cdc.gov
RI Needham, Larry/E-4930-2011
NR 46
TC 41
Z9 41
U1 0
U2 18
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD AUG
PY 2009
VL 117
IS 8
BP 1244
EP 1249
DI 10.1289/ehp.0800105
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 478DD
UT WOS:000268567100028
PM 19672404
ER
PT J
AU Cummings, KJ
Stefaniak, AB
Virji, MA
Kreiss, K
AF Cummings, Kristin J.
Stefaniak, Aleksandr B.
Virji, M. Abbas
Kreiss, Kathleen
TI A Reconsideration of Acute Beryllium Disease
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE acute; beryllium; beryllium disease; granuloma; hypersensitivity; immune
sensitization; pneumonitis
ID CONTACT-DERMATITIS; SENSITIZATION; OXIDE; PARTICLES; AEROSOLS; METAL;
RISK; IMMUNOLOGY; DIAGNOSIS; IMMUNITY
AB CONTEXT: Although chronic beryllium disease (CBD) is dearly an immune-mediated granulomatous reaction to beryllium, acute beryllium disease (ABD) is commonly considered an irritative chemical phenomenon related to high exposures. Given reported new cases of ABD and projected increased demand for beryllium, we aimed to reevaluate the pathophysiologic associations between ABD and CBD using two cases identified from a survey of beryllium production facility workers.
CASE PRESENTATION: Within weeks after exposure to beryllium fluoride began, two workers had systemic illness characterized by dermal and respiratory symptoms and precipitous declines in pulmonary function. Symptoms and pulmonary function abnormalities improved with cessation of exposure and, in one worker, recurred with repeat exposure. Bronchoalveolar lavage fluid analyses and blood beryllium lymphocyte proliferation tests revealed lymphocytic alveolitis and cellular immune recognition of beryllium. None of the measured air samples exceeded 100 mu g/m(3), and most were < 10 mu g/m(3), lower than usually described. In both cases, lung biopsy about 18 months after acute illness revealed noncaseating granulomas. Years after first exposure, the workers left employment because of CBD.
DISCUSSION: Contrary to common understanding, these cases suggest that ABD and CBD represent a continuum of disease, and both involve hypersensitivity reactions to beryllium. Differences in disease presentation and progression are likely influenced by the solubility of the beryllium compound involved.
RELEVANCE TO PRACTICE: ABD may occur after exposures lower than the high concentrations commonly described. Prudence dictates limitation of further beryllium exposure in both ABD and CBD.
C1 [Cummings, Kristin J.; Stefaniak, Aleksandr B.; Virji, M. Abbas; Kreiss, Kathleen] NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
RP Cummings, KJ (reprint author), NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, 1095 Willowdale Rd,MS-2800, Morgantown, WV 26505 USA.
EM cvx5@cdc.gov
RI Stefaniak, Aleksandr/I-3616-2012
FU National Institute for Occupational Safety and Health (NIOSH)
FX This work was supported by intramural funding from the National
Institute for Occupational Safety and Health (NIOSH).
NR 61
TC 24
Z9 25
U1 0
U2 4
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD AUG
PY 2009
VL 117
IS 8
BP 1250
EP 1256
DI 10.1289/ehp.0800455
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 478DD
UT WOS:000268567100029
PM 19672405
ER
PT J
AU Markotter, W
Kuzmin, IV
Rupprecht, CE
Nel, LH
AF Markotter, W.
Kuzmin, I. V.
Rupprecht, C. E.
Nel, L. H.
TI Lagos bat virus virulence in mice inoculated by the peripheral route
SO EPIDEMIOLOGY AND INFECTION
LA English
DT Article
DE Africa; glycoprotein; Lagos bat virus; lyssavirus; pathogenicity; rabies
ID FREE-TAILED BATS; RABIES VIRUS; TRANSMISSION EXPERIMENTS;
PHYLOGENETIC-RELATIONSHIPS; LYSSAVIRUS GENOTYPE; ADULT MICE;
PATHOGENICITY; GLYCOPROTEIN; EPIDEMIOLOGY; SEQUENCE
AB Lagos bat virus (LBV) constitutes genotype (gt) 2 in the Lyssavirus genus. In contrast to the gt 1 lyssavirus, rabies virus (RABV), LBV was reported to have markedly reduced levels of peripheral pathogenicity. However, this opinion was based on a study of one isolate of LBV only and the reduction in pathogenicity was essentially attributed to the amino-acid substitution at position 333 of glycoprotein ectodomain. In the present study we have demonstrated that peripheral pathogenicity of representatives of LBV in a murine model is as high as that of RABV. Comparison of amino-acid substitutions among the viral glycoproteins, demonstrated significant differences within two antigenic sites between different phylogenetic lineages of LBV. Such molecular variability potentially contributes to differences in peripheral pathogenicity of lyssaviruses.
C1 [Markotter, W.; Nel, L. H.] Univ Pretoria, Dept Microbiol & Plant Pathol, Fac Nat & Agr Sci, ZA-0001 Pretoria, South Africa.
[Kuzmin, I. V.; Rupprecht, C. E.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA USA.
RP Markotter, W (reprint author), Univ Pretoria, Dept Microbiol & Plant Pathol, Fac Nat & Agr Sci, ZA-0001 Pretoria, South Africa.
EM wanda.markotter@up.ac.za
RI Markotter, Wanda/A-2129-2010; Nel, Louis/F-1001-2012;
OI Markotter, Wanda/0000-0002-7550-0080
FU (Agricultural Research Council, Onderstepoort Veterinary Institute,
Rabies Unit, South Africa) [MOKVSA(252/97), LBVSA1982]; [Agence
Francaise de Securite Sanitaire des Aliments (AFSSA), France]
[LBV1999AFR]; National Research Foundation of South Africa; University
of Pretoria International Affairs Officee's Postgraduate Study Abroad
Bursary Programme,; US National Vaccine Program Office
FX The authors thank Dr C. T. Sabeta (Agricultural Research Council,
Onderstepoort Veterinary Institute, Rabies Unit, South Africa) for
providing the MOKVSA(252/97) and LBVSA1982 isolate and Dr F. Cliquet
[Agence Francaise de Securite Sanitaire des Aliments (AFSSA), France]
for providing the LBV1999AFR isolate. This study was supported in part
by the National Research Foundation of South Africa, the University of
Pretoria International Affairs Officee's Postgraduate Study Abroad
Bursary Programme, and the US National Vaccine Program Office. Use of
trade names and commercial sources are for identification only and do
not imply endorsement by the U.S. Department of Health and Human
Services. The findings and conclusions in this report are those of the
authors and do not necessarily represent the views of the funding
agencies.
NR 39
TC 15
Z9 16
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0950-2688
J9 EPIDEMIOL INFECT
JI Epidemiol. Infect.
PD AUG
PY 2009
VL 137
IS 8
BP 1155
EP 1162
DI 10.1017/S0950268808001945
PG 8
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 477MU
UT WOS:000268524000010
PM 19144249
ER
PT J
AU Banyai, K
Kisfali, P
Bogdan, A
Martella, V
Melegh, B
Erdman, D
Szucs, G
AF Banyai, K.
Kisfali, P.
Bogdan, A.
Martella, V.
Melegh, B.
Erdman, D.
Szucs, G.
TI Adenovirus gastroenteritis in Hungary, 2003-2006
SO EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
LA English
DT Article
ID STOOL SAMPLES; ROTAVIRUS
AB The incidence and type distribution of enteric human adenoviruses (HAds) among diarrheic children in south-western Hungary was investigated from 2003 through 2006. Laboratory studies were conducted using commercial antigen detection tests (latex agglutination or immunochromatography), polymerase chain reaction (PCR) amplification, single-strand conformation polymorphism, and sequencing and phylogenetic analysis of a conservative region of the HAd hexon gene. The overall rate of HAd infection in childhood gastroenteritis cases during the 4-year study was 8.1%, with a gradual decrease in detection rates from 11.7% in 2003 to 5.7% in 2006. Molecular studies of a subset of HAd-positive samples found that enteric HAd type 40 strains were identified only in 2003 and 2004, while HAd type 41 strains were identified throughout the 4-year study. Higher detection rates of non-enteric HAds was documented during the first half of the study period when latex agglutination was used in our laboratory for detection. Our study suggests that the choice of diagnostic method may profoundly influence the epidemiologic picture and disease burden attributed to enteric HAd infections.
C1 [Banyai, K.] Hungarian Acad Sci, Vet Med Res Inst, H-1143 Budapest, Hungary.
[Banyai, K.; Bogdan, A.; Szucs, G.] State Publ Hlth Serv, Baranya Cty Inst, Reg Lab Virol, H-7623 Pecs, Hungary.
[Kisfali, P.; Melegh, B.] Univ Pecs, Fac Med, Dept Med Genet & Child Dev, H-7624 Pecs, Hungary.
[Martella, V.] Univ Bari, Dept Anim Hlth & Well Being, I-70010 Bari, Italy.
[Erdman, D.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Banyai, K (reprint author), Hungarian Acad Sci, Vet Med Res Inst, Hungaria Krt 21, H-1143 Budapest, Hungary.
EM bkrota@hotmail.com
RI Martella, Vito/K-3146-2016;
OI Martella, Vito/0000-0002-5740-6947; Banyai,
Krisztian/0000-0002-6270-1772
FU Hungarian Scientific Research Fund [T049020]
FX The study was supported by the Hungarian Scientific Research Fund (OTKA,
T049020). K. B. is a recipient of the Bolyai Janos fellowship.
NR 9
TC 7
Z9 7
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0934-9723
J9 EUR J CLIN MICROBIOL
JI Eur. J. Clin. Microbiol. Infect. Dis.
PD AUG
PY 2009
VL 28
IS 8
BP 997
EP 999
DI 10.1007/s10096-009-0722-8
PG 3
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA 480ZU
UT WOS:000268776900017
PM 19259710
ER
PT J
AU Herrinton, LJ
Liu, LY
Fireman, B
Lewis, JD
Allison, JE
Flowers, N
Hutfless, S
Velayos, FS
Abramson, O
Altschuler, A
Perry, GS
AF Herrinton, Lisa J.
Liu, Liyan
Fireman, Bruce
Lewis, James D.
Allison, James E.
Flowers, Nicole
Hutfless, Susan
Velayos, Fernando S.
Abramson, Oren
Altschuler, Andrea
Perry, Geraldine S.
TI Time Trends in Therapies and Outcomes for Adult Inflammatory Bowel
Disease, Northern California, 1998-2005
SO GASTROENTEROLOGY
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; CROHNS-DISEASE; ULCERATIVE-COLITIS;
5-AMINOSALICYLIC ACID; AZATHIOPRINE; MAINTENANCE; RATES;
HOSPITALIZATION; METAANALYSIS; MANAGEMENT
AB BACKGROUND & AIMS: The management of inflammatory bowel disease (IBD) has become 'increasingly complicated, and it is unknown whether poor outcomes (prolonged steroid use, hospitalizations, and surgery) have declined in the general population. METHODS: This multilevel study used computerized clinical data. The study comprised 2892 adults with Crohn's disease (C]D) and 5895 with ulcerative colitis (UC) who received care at 16 medical centers within an integrated care organization in Northern California between 1998 and 2005. RESULTS: Time trends included (1) a shift in gastroenterology-related visits from the gastroenterology division to primary care, (2) increased use of IBD-related drugs, except for a 7% decline in use of S-aminosalicylate in CD and no change in steroid use for CD; (3) for the prevalence of prolonged steroid exposure (120 days of continuous use), a 36% decline for CD with a 27% increase for UC; (4) declines in the hospitalization rates of 33% for CD and 29% for UC; and (5) for the surgery rate, no significant change for CD with a 50% decline for UC. CONCLUSIONS: Declines in prolonged steroid exposure and the hospitalization rate for CD and in the hospitalization and surgery rate for UC are encouraging; however, the increase in prolonged steroid exposure for UC merits concern and further investigation. The variability in care patterns observed in this study suggests lack of standardization of care and the opportunity to identify targets for quality improvement. These findings should stimulate research to quantify the effect of current trends in IBD management.
C1 [Herrinton, Lisa J.; Liu, Liyan; Fireman, Bruce; Allison, James E.; Hutfless, Susan; Altschuler, Andrea] Kaiser Permanente No Calif, Div Res, Oakland, CA 94612 USA.
[Lewis, James D.] Univ Penn, Dept Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA.
[Lewis, James D.] Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
[Allison, James E.; Velayos, Fernando S.] Univ Calif San Francisco, Dept Internal Med, Div Gastroenterol, San Francisco, CA 94143 USA.
[Flowers, Nicole; Perry, Geraldine S.] Ctr Dis Control & Prevent, Emerging Invest & Analyt Methods Branch, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
[Hutfless, Susan] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
[Abramson, Oren] Kaiser Permanente, Div Pediat Gastroenterol, Santa Clara, CA USA.
RP Herrinton, LJ (reprint author), Kaiser Permanente No Calif, Div Res, 2000 Broadway Ave, Oakland, CA 94612 USA.
EM lisa.herrinton@kp.org
OI Hutfless, Susan/0000-0002-6311-2611
NR 32
TC 58
Z9 58
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
J9 GASTROENTEROLOGY
JI Gastroenterology
PD AUG
PY 2009
VL 137
IS 2
BP 502
EP 511
DI 10.1053/j.gastro.2009.04.063
PG 10
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 477WZ
UT WOS:000268551000024
PM 19445944
ER
PT J
AU Whitehead, WE
Borrud, L
Goode, PS
Meikle, S
Mueller, ER
Tuteja, A
Weidner, A
Weinstein, M
Ye, W
AF Whitehead, William E.
Borrud, Lori
Goode, Patricia S.
Meikle, Susan
Mueller, Elizabeth R.
Tuteja, Ashok
Weidner, Alison
Weinstein, Milena
Ye, Wen
CA Pelvic Floor Disorders Network
TI Fecal Incontinence in US Adults: Epidemiology and Risk Factors
SO GASTROENTEROLOGY
LA English
DT Article
ID PELVIC FLOOR DISORDERS; PAD-WEIGHING TESTS; SEVERITY INDEX; STOOL FORM;
URINARY-INCONTINENCE; PREVALENCE; WOMEN; COMMUNITY; TRANSIT; SYMPTOMS
AB BACKGROUND & AIMS: The study aims were to estimate the prevalence of different types and frequencies of fecal incontinence (FI), describe demographic factors, and identify risk factors. METHODS: The National Health and Nutrition Examination Survey (NHANES) assesses health status in the civilian noninstitutionalized US population. The validated Fecal Incontinence Severity Index was added to NHANES in 2005-2006. Participants were 2229 women and 2079 men aged 20 years or older. FI was defined as accidental leakage of solid, liquid, or mucus at least once in the preceding month. Sampling weights were used to obtain prevalence estimates for the national population. Multivariate logistic regression identified independent risk factors. RESULTS: The estimated prevalence of FI in noninstitutionalized US adults is 8.3% (95% confidence interval, 7.1-9.5) and consists of liquid stool in 6.2%, solid stool in 1.6%, and mucus in 3.1%. It occurs at least weekly in 2.7%. Prevalence is similar in women (8.9%) and men (7.7%) and increases with age from 2.6% in 20 to 29 year olds up to 15.3% in participants aged 70 years and older. FI is not significantly associated with race/ethnicity, education, income, or marital status after adjusting for age. Independent risk factors in women are advancing age, loose or watery stools, more than 21 stools per week, multiple chronic illnesses, and urinary incontinence. Independent risk factors in men are age, loose or watery stools, poor self-rated health, and urinary incontinence. CONCLUSIONS: FI is a prevalent age-related disorder. Chronic diarrhea is a strong modifiable risk factor that may form the basis for prevention and treatment.
C1 [Whitehead, William E.] Univ N Carolina, Dept Med, Ctr Funct Gastrointestinal & Motil Disorders, Chapel Hill, NC 27599 USA.
[Whitehead, William E.] Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC 27599 USA.
[Borrud, Lori] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
[Goode, Patricia S.] Vet Affairs Med Ctr, Birmingham Atlanta Geriatr Res Educ & Clin Ctr, Birmingham, AL USA.
[Goode, Patricia S.] Univ Alabama, Birmingham, AL USA.
[Meikle, Susan] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Pelv Floor Disorders Program, Contracept & Reprod Hlth Branch, Bethesda, MD USA.
[Mueller, Elizabeth R.] Loyola Univ, Med Ctr, Dept Urol, Maywood, IL 60153 USA.
[Mueller, Elizabeth R.] Loyola Univ, Med Ctr, Dept Obstet & Gynecol, Maywood, IL 60153 USA.
[Tuteja, Ashok] George E Wahlen Vet Affairs Med Ctr, Salt Lake City, UT USA.
[Tuteja, Ashok] Univ Utah, Dept Med, Salt Lake City, UT 84112 USA.
[Weidner, Alison] Duke Univ, Sch Med, Dept Obstet & Gynecol, Durham, NC USA.
[Weinstein, Milena] Univ Calif San Diego, Dept Obstet & Gynecol, San Diego, CA 92103 USA.
[Ye, Wen] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
RP Whitehead, WE (reprint author), Univ N Carolina, Dept Med, Ctr Funct Gastrointestinal & Motil Disorders, Campus Box 7080, Chapel Hill, NC 27599 USA.
EM william_whitehead@med.unc.edu
OI Mueller, Elizabeth R./0000-0003-3069-4069
FU NICHD NIH HHS [U10 HD041268-01, U01 HD041249, U01 HD041249-01, U01
HD41249, U10 HD041248, U10 HD041248-01, U10 HD041250, U10 HD041250-01,
U10 HD041261, U10 HD041261-01, U10 HD041263, U10 HD041263-01, U10
HD041267, U10 HD041267-01, U10 HD041268, U10 HD041269, U10 HD041269-01,
U10 HD41248, U10 HD41250, U10 HD41261, U10 HD41263, U10 HD41267, U10
HD41268, U10 HD41269]
NR 28
TC 200
Z9 203
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
J9 GASTROENTEROLOGY
JI Gastroenterology
PD AUG
PY 2009
VL 137
IS 2
BP 512
EP 517
DI 10.1053/j.gastro.2009.04.054
PG 6
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 477WZ
UT WOS:000268551000025
PM 19410574
ER
PT J
AU Khoury, MJ
McBride, CM
Schully, SD
Ioannidis, JPA
Feero, WG
Janssens, ACJW
Gwinn, M
Simons-Morton, DG
Bernhardt, JM
Cargill, M
Chanock, SJ
Church, GM
Coates, RJ
Collins, FS
Croyle, RT
Davis, BR
Downing, GJ
DuRoss, A
Friedman, S
Gail, MH
Ginsburg, GS
Green, RC
Greene, MH
Greenland, P
Gulcher, JR
Hsu, A
Hudson, KL
Kardia, SLR
Kimmel, PL
Lauer, MS
Miller, AM
Offit, K
Ransohoff, DF
Roberts, JS
Rasooly, RS
Stefansson, K
Terry, SF
Teutsch, SM
Trepanier, A
Wanke, KL
Witte, JS
Xu, JF
AF Khoury, Muin J.
McBride, Colleen M.
Schully, Sheri D.
Ioannidis, John P. A.
Feero, W. Gregory
Janssens, A. Cecile J. W.
Gwinn, Marta
Simons-Morton, Denise G.
Bernhardt, Jay M.
Cargill, Michele
Chanock, Stephen J.
Church, George M.
Coates, Ralph J.
Collins, Francis S.
Croyle, Robert T.
Davis, Barry R.
Downing, Gregory J.
DuRoss, Amy
Friedman, Susan
Gail, Mitchell H.
Ginsburg, Geoffrey S.
Green, Robert C.
Greene, Mark H.
Greenland, Philip
Gulcher, Jeffrey R.
Hsu, Andro
Hudson, Kathy L.
Kardia, Sharon L. R.
Kimmel, Paul L.
Lauer, Michael S.
Miller, Amy M.
Offit, Kenneth
Ransohoff, David F.
Roberts, J. Scott
Rasooly, Rebekah S.
Stefansson, Kari
Terry, Sharon F.
Teutsch, Steven M.
Trepanier, Angela
Wanke, Kay L.
Witte, John S.
Xu, Jianfeng
TI The Scientific Foundation for Personal Genomics: Recommendations from a
National Institutes of Health-Centers for Disease Control and Prevention
Multidisciplinary Workshop
SO GENETICS IN MEDICINE
LA English
DT Review
DE behavioral sciences; epidemiologic methods; evidence-based medicine;
genetics; genetic testing; genomics; medicine; public health
ID EGAPP WORKING GROUP; GENETIC RISK FEEDBACK; BREAST-CANCER; WIDE
ASSOCIATION; COMMON DISEASE; ALZHEIMERS-DISEASE; PREDICTIVE ABILITY;
BEHAVIOR-CHANGE; ROC CURVE; SUSCEPTIBILITY
AB The increasing availability of personal genomic tests has led to discussions about the validity and utility of such tests and the balance of benefits and harms. A multidisciplinary workshop was convened by the National Institutes of Health and the Centers for Disease Control and Prevention to review the scientific foundation for using personal genomics in risk assessment and disease prevention and to develop recommendations for targeted research. The clinical validity and utility of personal genomics is a moving target with rapidly developing discoveries but little translation research to close the gap between discoveries and health impact. Workshop participants made recommendations in five domains: (1) developing and applying scientific standards for assessing personal genomic tests; (2) developing and applying a multidisciplinary research agenda, including observational studies and clinical trials to fill knowledge gaps in clinical validity and utility; (3) enhancing credible knowledge synthesis and information dissemination to clinicians and consumers; (4) linking scientific findings to evidence-based recommendations for use of personal genomics; and (5) assessing how the concept of personal utility can affect health benefits, costs, and risks by developing appropriate metrics for evaluation. To fulfill the promise of personal genomics, a rigorous multidisciplinary research agenda is needed. Genet Med 2009:11(8):559-567.
C1 [Khoury, Muin J.; Gwinn, Marta; Coates, Ralph J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA.
[Khoury, Muin J.; Schully, Sheri D.; Chanock, Stephen J.; Croyle, Robert T.; Gail, Mitchell H.; Greene, Mark H.] NCI, NIH, Bethesda, MD 20892 USA.
[McBride, Colleen M.; Feero, W. Gregory; Collins, Francis S.] NHGRI, NIH, Bethesda, MD 20892 USA.
[Ioannidis, John P. A.] Univ Ioannina, Sch Med, Dept Epidemiol, GR-45110 Ioannina, Greece.
[Ioannidis, John P. A.] Tufts Univ, Sch Med, Boston, MA 02111 USA.
[Janssens, A. Cecile J. W.] Erasmus Univ, Dept Epidemiol & Biostat, Med Ctr, NL-3000 DR Rotterdam, Netherlands.
[Simons-Morton, Denise G.; Lauer, Michael S.] NHLBI, NIH, Bethesda, MD 20892 USA.
[Bernhardt, Jay M.] Ctr Dis Control & Prevent, Natl Ctr Hlth Mkt, Atlanta, GA USA.
[Cargill, Michele; DuRoss, Amy] Navigenics, Redwood Shores, CA USA.
[Church, George M.] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.
[Davis, Barry R.] Univ Texas Houston, Sch Publ Hlth, Dept Biostat, Houston, TX USA.
[Downing, Gregory J.] US Dept HHS, Washington, DC 20201 USA.
[Friedman, Susan] FORCE, Tampa, FL USA.
[Ginsburg, Geoffrey S.] Duke Univ, Inst Genome Sci & Policy, Ctr Genom Med, Durham, NC USA.
[Green, Robert C.] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA.
[Green, Robert C.] Boston Univ, Sch Med, Dept Med Genet, Boston, MA 02118 USA.
[Green, Robert C.] Boston Univ, Sch Med, Dept Epidemiol, Boston, MA 02118 USA.
[Green, Robert C.] Boston Univ, Sch Publ Hlth, Dept Neurol, Boston, MA USA.
[Green, Robert C.] Boston Univ, Sch Publ Hlth, Dept Med Genet, Boston, MA USA.
[Green, Robert C.] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
[Greenland, Philip] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA.
[Gulcher, Jeffrey R.; Stefansson, Kari] deCODE Genet, Reykjavik, Iceland.
[Hsu, Andro] 23andMe Inc, Mountain View, CA USA.
[Hudson, Kathy L.] Johns Hopkins Univ, Genet & Publ Policy Ctr, Washington, DC USA.
[Kardia, Sharon L. R.] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
[Kimmel, Paul L.; Rasooly, Rebekah S.] NIDDKD, NIH, Bethesda, MD 20892 USA.
[Miller, Amy M.] Personalized Med Coalit, Washington, DC USA.
[Offit, Kenneth] Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA.
[Ransohoff, David F.] Univ N Carolina, Dept Med, Chapel Hill, NC USA.
[Ransohoff, David F.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
[Ransohoff, David F.] Univ N Carolina, Dept Biostat, Chapel Hill, NC USA.
[Roberts, J. Scott] Univ Michigan, Sch Publ Hlth, Dept Hlth Behav & Hlth Educ, Ann Arbor, MI 48109 USA.
[Terry, Sharon F.] Genet Alliance, Washington, DC USA.
[Teutsch, Steven M.] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA.
[Trepanier, Angela] Wayne State Univ, Ctr Mol Med & Genet, Detroit, MI USA.
[Wanke, Kay L.] NIH, Off Behav & Social Sci Res, Bethesda, MD 20892 USA.
[Witte, John S.] Univ Calif San Francisco, Dept Epidemiol & Biostat, Inst Human Genet, San Francisco, CA 94143 USA.
[Xu, Jianfeng] Wake Forest Univ, Sch Med, Ctr Canc Genom, Winston Salem, NC 27109 USA.
RP Khoury, MJ (reprint author), Ctr Dis Control & Prevent, Off Publ Hlth Genom, 1600 Clifton Rd,MS E61, Atlanta, GA 30333 USA.
EM mkhoury@cdc.gov
RI Ioannidis, John/G-9836-2011; Lauer, Michael/L-9656-2013;
OI Lauer, Michael/0000-0002-9217-8177; Bernhardt, Jay/0000-0002-2045-4005;
Rasooly, Rebekah/0000-0002-6357-5528; Janssens, A
Cecile/0000-0002-6153-4976
FU NCRR NIH HHS [M01 RR000533, M01 RR000533-360391]; NHGRI NIH HHS [R01
HG002213, R01 HG002213-01, R01 HG005092, R01 HG005092-01A1]; NIA NIH HHS
[K24 AG027841, K24 AG027841-01A1, P30 AG013846, P30 AG013846-069001]
NR 93
TC 122
Z9 126
U1 4
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1098-3600
J9 GENET MED
JI Genet. Med.
PD AUG
PY 2009
VL 11
IS 8
BP 559
EP 567
DI 10.1097/GIM.0b013e3181b13a6c
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA 487KV
UT WOS:000269273900001
PM 19617843
ER
PT J
AU Grosse, SD
McBride, CM
Evans, JP
Khoury, MJ
AF Grosse, Scott D.
McBride, Colleen M.
Evans, James. P.
Khoury, Muin J.
TI Personal utility and genomic information: Look before you leap
SO GENETICS IN MEDICINE
LA English
DT Editorial Material
ID WOMENS PREFERENCES; BREAST-CANCER; CHILDREN; DISEASE
C1 [Grosse, Scott D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[McBride, Colleen M.] NHGRI, Social & Behav Res Branch, NIH, Bethesda, MD 20892 USA.
[Evans, James. P.] Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
[Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA.
RP Grosse, SD (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,Mail Stop E88, Atlanta, GA 30333 USA.
EM sgrosse@cdc.gov
FU Intramural NIH HHS [Z01 HG200344-01]
NR 20
TC 38
Z9 38
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1098-3600
J9 GENET MED
JI Genet. Med.
PD AUG
PY 2009
VL 11
IS 8
BP 575
EP 576
DI 10.1097/GIM.0b013e3181af0a80
PG 2
WC Genetics & Heredity
SC Genetics & Heredity
GA 487KV
UT WOS:000269273900004
PM 19623080
ER
PT J
AU Kolor, K
Liu, TB
St Pierre, J
Khoury, MJ
AF Kolor, Katherine
Liu, Tiebin
St Pierre, Jeanette
Khoury, Muin J.
TI Health care provider and consumer awareness, perceptions, and use of
direct-to-consumer personal genomic tests, United States, 2008
SO GENETICS IN MEDICINE
LA English
DT Letter
C1 [Kolor, Katherine; Liu, Tiebin; St Pierre, Jeanette; Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA.
RP Kolor, K (reprint author), Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA.
NR 4
TC 51
Z9 52
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1098-3600
J9 GENET MED
JI Genet. Med.
PD AUG
PY 2009
VL 11
IS 8
BP 595
EP 595
PG 1
WC Genetics & Heredity
SC Genetics & Heredity
GA 487KV
UT WOS:000269273900010
PM 19680046
ER
PT J
AU Cornell, CE
Littleton, MA
Greene, PG
Pulley, L
Brownstein, JN
Sanderson, BK
Stalker, VG
Matson-Koffman, D
Struempler, B
Raczynski, JM
AF Cornell, C. E.
Littleton, M. A.
Greene, P. G.
Pulley, L.
Brownstein, J. N.
Sanderson, B. K.
Stalker, V. G.
Matson-Koffman, D.
Struempler, B.
Raczynski, J. M.
TI A Community Health Advisor Program to reduce cardiovascular risk among
rural African-American women
SO HEALTH EDUCATION RESEARCH
LA English
DT Article
ID HEART-DISEASE; EMPOWERMENT; WORKERS; PREVENTION; PROMOTION; PROJECT;
BLACK; CARE; INTERVENTION; EDUCATION
AB The Uniontown, Alabama Community Health Project trained and facilitated Community Health Advisors (CHAs) in conducting a theory-based intervention designed to reduce the risk for cardiovascular disease (CVD) among rural African-American women. The multiphased project included formative evaluation and community organization, CHA recruitment and training, community intervention and maintenance. Formative data collected to develop the training, intervention and evaluation methods and materials indicated the need for programs to increase knowledge, skills and resources for changing behaviors that increase the risk of CVD. CHAs worked in partnership with staff to develop, implement, evaluate and maintain strategies to reduce risk for CVD in women and to influence city officials, business owners and community coalitions to facilitate project activities. Process data documented sustained increases in social capital and community capacity to address health-related issues, as well as improvements in the community's physical infrastructure. This project is unique in that it documents that a comprehensive CHA-based intervention for CVD can facilitate wide-reaching changes in capacity to address health issues in a rural community that include improvements in community infrastructure and are sustained beyond the scope of the originally funded intervention.
C1 [Cornell, C. E.; Greene, P. G.; Pulley, L.; Raczynski, J. M.] Univ Arkansas Med Sci, Fay W Boozman Coll Publ Hlth, Dept Hlth Behav & Hlth Educ, Little Rock, AR 72205 USA.
[Littleton, M. A.] E Tennessee State Univ, Coll Publ Hlth, Dept Publ Hlth, Johnson City, TN 37614 USA.
[Brownstein, J. N.; Matson-Koffman, D.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Stalker, V. G.] Univ Alabama, Dept Hlth Behav, Sch Publ Hlth, Birmingham, AL 35205 USA.
[Sanderson, B. K.] Univ Alabama, Sch Publ Hlth, Dept Med, Div Cardiovasc Med, Birmingham, AL 35205 USA.
[Struempler, B.] Auburn Univ, Dept Nutr & Food Sci, Auburn, AL 36849 USA.
RP Cornell, CE (reprint author), Univ Arkansas Med Sci, Fay W Boozman Coll Publ Hlth, Dept Hlth Behav & Hlth Educ, Little Rock, AR 72205 USA.
EM ccornell@uams.edu
FU PHS HHS [U48/CCU409679]
NR 55
TC 14
Z9 14
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1153
J9 HEALTH EDUC RES
JI Health Educ. Res.
PD AUG
PY 2009
VL 24
IS 4
BP 622
EP 633
DI 10.1093/her/cyn063
PG 12
WC Education & Educational Research; Public, Environmental & Occupational
Health
SC Education & Educational Research; Public, Environmental & Occupational
Health
GA 469IA
UT WOS:000267888500007
PM 19047648
ER
PT J
AU Waller, E
Millage, K
Blakely, WF
Ross, JA
Mercier, JR
Sandgren, DJ
Levine, IH
Dickerson, WE
Nemhauser, JB
Nasstrom, JS
Sugiyama, G
Homann, S
Buddemeier, BR
Curling, CA
Disraelly, DS
AF Waller, E.
Millage, Kyle
Blakely, William F.
Ross, James A.
Mercier, John R.
Sandgren, David J.
Levine, Ira H.
Dickerson, William E.
Nemhauser, Jeffrey B.
Nasstrom, John S.
Sugiyama, Gayle
Homann, Steve
Buddemeier, Brooke R.
Curling, Carl A.
Disraelly, Deena S.
TI OVERVIEW OF HAZARD ASSESSMENT AND EMERGENCY PLANNING SOFTWARE OF USE TO
RN FIRST RESPONDERS
SO HEALTH PHYSICS
LA English
DT Article
DE biological indicators; computers; emergencies, radiological; emergency
planning
ID BIOLOGICAL DOSIMETRY; RADIATION
AB There are numerous software tools available for field deployment, reach-back, training and planning use in the event of a radiological or nuclear terrorist event. Specialized software tools used by CBRNe responders can increase information available and the speed and accuracy of the response, thereby ensuring that radiation doses to responders, receivers, and the general public are kept as low as reasonably achievable. Software designed to provide health care providers with assistance in selecting appropriate countermeasures or therapeutic interventions in a timely fashion can improve the potential for positive patient outcome. This paper reviews various software applications of relevance to radiological and nuclear events that are currently in use by first responders, emergency planners, medical receivers, and criminal investigators. Health Phys. 97(2):145-156; 2009
C1 [Waller, E.] Univ Western Ontario, Inst Technol, Fac Energy Syst & Nucl Sci, Oshawa, ON, Canada.
[Millage, Kyle] Appl Res Associates Inc, Arlington, VA 22203 USA.
[Blakely, William F.; Ross, James A.; Mercier, John R.; Sandgren, David J.; Levine, Ira H.; Dickerson, William E.] Armed Forces Radiobiol Res Inst, Bethesda, MD 20889 USA.
[Nemhauser, Jeffrey B.] Ctr Dis Control & Prevent, Ne Atlanta, GA 30341 USA.
[Nasstrom, John S.; Sugiyama, Gayle; Homann, Steve; Buddemeier, Brooke R.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA.
[Curling, Carl A.; Disraelly, Deena S.] Inst Def Anal, Alexandria, VA 22311 USA.
RP Waller, E (reprint author), Univ Western Ontario, Inst Technol, Fac Energy Syst & Nucl Sci, 2000 Simcoe St N, Oshawa, ON, Canada.
EM ed.waller@uoit.ca
NR 24
TC 11
Z9 11
U1 2
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0017-9078
EI 1538-5159
J9 HEALTH PHYS
JI Health Phys.
PD AUG
PY 2009
VL 97
IS 2
BP 145
EP 156
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health;
Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical
Imaging
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Nuclear Science & Technology; Radiology, Nuclear Medicine &
Medical Imaging
GA 470WN
UT WOS:000268013200006
PM 19590274
ER
PT J
AU Tveit, A
Bruce, MG
Bruden, D
Morris, J
Hurlburt, D
McMahon, B
AF Tveit, A.
Bruce, M. G.
Bruden, D.
Morris, J.
Hurlburt, D.
McMahon, B.
TI Antimicrobial Resistance of H-pylori Isolates in Alaska Native Persons
from 2000-2008: Results from the Alaska Sentinel Surveillance Project
SO HELICOBACTER
LA English
DT Meeting Abstract
CT 22nd International Workshop on Helicobacter and Related Bacteria in
Chronic Digestive Inflammation and Gastric Cancer
CY SEP 17-19, 2009
CL Oporto, PORTUGAL
SP European Helicobacter Study Grp
C1 [Tveit, A.; McMahon, B.] Alaska Native Med Ctr, Anchorage, AK USA.
[Bruce, M. G.; Bruden, D.; Morris, J.; Hurlburt, D.; McMahon, B.] Ctr Dis Control & Prevent, Anchorage, AK USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1083-4389
J9 HELICOBACTER
JI Helicobacter
PD AUG
PY 2009
VL 14
IS 4
BP 328
EP 328
PG 1
WC Gastroenterology & Hepatology; Microbiology
SC Gastroenterology & Hepatology; Microbiology
GA 474FZ
UT WOS:000268269300054
ER
PT J
AU Clark, SJ
Cowan, AE
Wortley, PM
AF Clark, Sarah J.
Cowan, Anne E.
Wortley, Pascale M.
TI Worksite policies related to influenza vaccination A cross-sectional
survey of US registered nurses
SO HUMAN VACCINES
LA English
DT Article
DE influenza; vaccine; registered nurses; worksite programs; mail survey
ID HEALTH-CARE WORKERS; UNITED-STATES; RATES; HOSPITALS; KNOWLEDGE;
PROGRAM; RECEIPT
AB To increase the rate of influenza vaccination among healthcare personnel, national recommendations call for worksites to adopt a multi-pronged strategy to encourage vaccination. The objective of this study was to explore existing worksite influenza vaccination policies and attitudes toward the use of declination forms based on a cross-sectional mail survey of 2,000 registered nurses in four US states. The majority (59%) of respondents reported receiving influenza vaccine during the 2005-06 influenza season. Just over half (55%) of respondents reported that their worksite strongly recommended influenza vaccination for employees. Most worksites made vaccine available to employees via one or more venues (95%) and used one or more strategies to inform employees about influenza vaccination (91%). Worksite policies supportive of HCP influenza vaccination were reported more frequently by vaccinated nurses and those in hospital-based settings. The majority of respondents supported the use of declination forms for influenza vaccination. Although many healthcare worksites have policies in place to support influenza vaccination among their employees, continued efforts to expand worksite policies and practices are important for increasing vaccination rates and may need to be targeted differently for hospital-and non-hospital-based settings.
C1 [Clark, Sarah J.; Cowan, Anne E.] Univ Michigan, Child Hlth Evaluat & Res Unit, Ann Arbor, MI 48109 USA.
[Wortley, Pascale M.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
RP Clark, SJ (reprint author), 300 N Ingalls,Rm 6E06, Ann Arbor, MI 48103 USA.
EM saclark@med.umich.edu
NR 19
TC 4
Z9 4
U1 0
U2 0
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1002 WEST AVENUE, 2ND FLOOR, AUSTIN, TX 78701 USA
SN 1554-8619
J9 HUM VACCINES
JI Hum. Vaccines
PD AUG
PY 2009
VL 5
IS 8
BP 545
EP 550
PG 6
WC Biotechnology & Applied Microbiology; Immunology
SC Biotechnology & Applied Microbiology; Immunology
GA 541LN
UT WOS:000273417300006
PM 19458489
ER
PT J
AU Salmon, DA
Smith, PJ
Pan, WKY
Navar, AM
Omer, SB
Halsey, NA
AF Salmon, Daniel A.
Smith, Philip J.
Pan, William K. Y.
Navar, Ann Marie
Omer, Saad B.
Halsey, Neal A.
TI Disparities in preschool immunization coverage associated with maternal
age
SO HUMAN VACCINES
LA English
DT Article
DE immunization; vaccine; maternal age; health disparities; vaccine
coverage
ID VACCINATION COVERAGE; RISK-FACTORS; CHILDHOOD IMMUNIZATIONS; DELAYED
IMMUNIZATION; UNITED-STATES; CHILDREN; INFANTS; MEASLES; SYSTEM; RATES
AB Associations between maternal age and preschool immunization coverage are unclear. This study aimed to determine if maternal age is associated with preschool immunization coverage and the importance of maternal age compared with other factors affecting vaccination coverage. Data from the 2001-2003 National Immunization Survey (NIS) were used to estimate vaccine coverage. Children were considered up-to-date (UTD) if they received >= 4 doses of DTaP, >= 3 doses of polio, >= 1 doses of MMR, >= 3 doses of Hib and >= 3 doses of Hep B. Bivariate and multivariate relationships between UTD coverage and maternal, child and household factors were evaluated. Classification tree analysis assessed complex interactions between maternal, child and household factors associated with UTD coverage and isolated the most important factors in predicting UTD coverage. UTD coverage was significantly associated with maternal age: coverage increased as maternal age increased. Coverage among children with 17 year old mothers was 64%; coverage among children of mothers 17-26 years old increased by 16.3% overall (approximately 1.8% per year). After 26 years of age, coverage did not increase significantly as maternal age increased. The relationship between maternal age and UTD coverage remained statistically significant after adjusting for a broad range of maternal, child and household factors. Classification tree analysis suggested that maternal age is the most important factor associated with vaccine coverage. More research is needed to determine the reasons for underimmunization of children born to young mothers.
C1 [Salmon, Daniel A.; Omer, Saad B.; Halsey, Neal A.] Johns Hopkins Bloomberg Sch Publ Hlth, Inst Vaccine Safety, Baltimore, MD 21205 USA.
[Salmon, Daniel A.; Pan, William K. Y.; Navar, Ann Marie; Omer, Saad B.; Halsey, Neal A.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA.
[Smith, Philip J.] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Navar, Ann Marie] Duke Univ, Sch Med, Durham, NC USA.
RP Halsey, NA (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Inst Vaccine Safety, 615 N Wolfe St W5041, Baltimore, MD 21205 USA.
EM nhalsey@jhsph.edu
RI Omer, Saad/K-1182-2012
OI Omer, Saad/0000-0002-5383-3474
FU Sanofi Pasteur; NIH
FX Dr. Salmon has research grants from NIH and CDC and is a paid consultant
for Merck through their vaccine policy board. Dr. Halsey received salary
support through a grant from Sanofi Pasteur. No other authors have any
conflicts.
NR 45
TC 1
Z9 1
U1 2
U2 3
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1002 WEST AVENUE, 2ND FLOOR, AUSTIN, TX 78701 USA
SN 1554-8619
J9 HUM VACCINES
JI Hum. Vaccines
PD AUG
PY 2009
VL 5
IS 8
BP 557
EP 561
PG 5
WC Biotechnology & Applied Microbiology; Immunology
SC Biotechnology & Applied Microbiology; Immunology
GA 541LN
UT WOS:000273417300008
PM 19556887
ER
PT J
AU Cox-Ganser, JM
Rao, CY
Park, JH
Schumpert, JC
Kreiss, K
AF Cox-Ganser, J. M.
Rao, C. Y.
Park, J. -H.
Schumpert, J. C.
Kreiss, K.
TI Asthma and respiratory symptoms in hospital workers related to dampness
and biological contaminants
SO INDOOR AIR
LA English
DT Article
DE Building-related asthma; Indoor environmental quality; Mold; Ergosterol;
Healthcare workers; Dampness
ID HEALTH-CARE WORKERS; INDOOR AIR-QUALITY; OCCUPATIONAL ASTHMA; CHILDHOOD
ASTHMA; RISK-FACTORS; EXPOSURE; CHILDREN; MOLD; FORMALDEHYDE; PREVALENCE
AB P>The National Institute for Occupational Safety and Health investigated respiratory symptoms and asthma in relation to damp indoor environments in employees of two hospitals. A cluster of six work-related asthma cases from one hospital department, whose symptoms arose during a time of significant water incursions, led us to conduct a survey of respiratory health in 1171/1834 employees working in the sentinel cases hospital and a nearby hospital without known indoor environmental concerns. We carried out observational assessment of dampness, air, chair, and floor dust sampling for biological contaminants, and investigation of exposure-response associations for about 500 participants. Many participants with post-hire onset asthma reported diagnosis dates in a period of water incursions and renovations. Post-hire asthma and work-related lower respiratory symptoms were positively associated with the dampness score. Work-related lower respiratory symptoms showed monotonically increasing odds ratios with ergosterol, a marker of fungal biomass. Other fungal and bacterial indices, particle counts, cat allergen and latex allergen were associated with respiratory symptoms. Our data imply new-onset of asthma in relation to water damage, and indicate that work-related respiratory symptoms in hospital workers may be associated with diverse biological contaminants.
C1 [Cox-Ganser, J. M.] NIOSH, Field Studies Branch, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
[Schumpert, J. C.] Resources Environm & Occupat Hlth Inc, Missoula, MT USA.
RP Cox-Ganser, JM (reprint author), NIOSH, Field Studies Branch, Div Resp Dis Studies, Ctr Dis Control & Prevent, 1095 Willowdale Rd,M-S 2800, Morgantown, WV 26505 USA.
EM Jcoxganser@cdc.gov
FU National Institute for Occupational Safety and Health
FX The authors would like to thank the NIOSH field team for their work
during the site visits, Ken Wallingford and Abbas Virji for technical
review of the paper, the hospital management for their cooperation
enabling data collection, and the hospital employees who were
participants in the study. This study was funded by the National
Institute for Occupational Safety and Health.
NR 40
TC 15
Z9 16
U1 4
U2 10
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0905-6947
J9 INDOOR AIR
JI Indoor Air
PD AUG
PY 2009
VL 19
IS 4
BP 280
EP 290
DI 10.1111/j.1600-0668.2009.00586.x
PG 11
WC Construction & Building Technology; Engineering, Environmental; Public,
Environmental & Occupational Health
SC Construction & Building Technology; Engineering; Public, Environmental &
Occupational Health
GA 471BZ
UT WOS:000268029700002
PM 19500175
ER
PT J
AU Boyer, AE
Quinn, CP
Hoffmaster, AR
Kozel, TR
Saile, E
Marston, CK
Percival, A
Plikaytis, BD
Woolfitt, AR
Gallegos, M
Sabourin, P
McWilliams, LG
Pirkle, JL
Barr, JR
AF Boyer, Anne E.
Quinn, Conrad P.
Hoffmaster, Alex R.
Kozel, Thomas R.
Saile, Elke
Marston, Chung K.
Percival, Ann
Plikaytis, Brian D.
Woolfitt, Adrian R.
Gallegos, Maribel
Sabourin, Patrick
McWilliams, Lisa G.
Pirkle, James L.
Barr, John R.
TI Kinetics of Lethal Factor and Poly-D-Glutamic Acid Antigenemia during
Inhalation Anthrax in Rhesus Macaques
SO INFECTION AND IMMUNITY
LA English
DT Article
ID INNATE IMMUNE-RESPONSE; BACILLUS-ANTHRACIS; PROTECTIVE ANTIGEN;
IMMUNOGLOBULIN-G; TOXIN; NEUTROPHILS; RESISTANCE; HOST; MICE; INFECTION
AB Systemic anthrax manifests as toxemia, rapidly disseminating septicemia, immune collapse, and death. Virulence factors include the anti-phagocytic gamma-linked poly-D-glutamic acid (PGA) capsule and two binary toxins, complexes of protective antigen (PA) with lethal factor (LF) and edema factor. We report the characterization of LF, PA, and PGA levels during the course of inhalation anthrax in five rhesus macaques. We describe bacteremia, blood differentials, and detection of the PA gene (pagA) by PCR analysis of the blood as confirmation of infection. For four of five animals tested, LF exhibited a triphasic kinetic profile. LF levels (mean +/- standard error [SE] between animals) were low at 24 h postchallenge (0.03 +/- 1.82 ng/ml), increased at 48 h to 39.53 +/- 0.12 ng/ml (phase 1), declined at 72 h to 13.31 +/- 0.24 ng/ml (phase 2), and increased at 96 h (82.78 +/- 2.01 ng/ml) and 120 h (185.12 +/- 5.68 ng/ml; phase 3). The fifth animal had an extended phase 2. PGA levels were triphasic; they were nondetectable at 24 h, increased at 48 h (2,037 +/- 2 ng/ml), declined at 72 h (14 +/- 0.2 ng/ml), and then increased at 96 h (3,401 +/- 8 ng/ml) and 120 h (6,004 +/- 187 ng/ml). Bacteremia was also triphasic: positive at 48 h, negative at 72 h, and positive at euthanasia. Blood neutrophils increased from preexposure (34.4% +/- 0.13%) to 48 h (75.6% +/- 0.08%) and declined at 72 h (62.4% +/- 0.05%). The 72-h declines may establish a "go/no go" turning point in infection, after which systemic bacteremia ensues and the host's condition deteriorates. This study emphasizes the value of LF detection as a tool for early diagnosis of inhalation anthrax before the onset of fulminant systemic infection.
C1 [Gallegos, Maribel; McWilliams, Lisa G.; Barr, John R.] Ctr Dis Control & Prevent, Battelle Mem Inst, Atlanta, GA 30341 USA.
[Boyer, Anne E.; Woolfitt, Adrian R.; Gallegos, Maribel; McWilliams, Lisa G.; Pirkle, James L.; Barr, John R.] Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Quinn, Conrad P.; Saile, Elke; Plikaytis, Brian D.] Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Hoffmaster, Alex R.; Marston, Chung K.] Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA.
[Kozel, Thomas R.; Percival, Ann] Univ Nevada, Sch Med, Reno, NV 89557 USA.
[Sabourin, Patrick] Battelle Biomed Res Ctr, W Jefferson, OH USA.
RP Barr, JR (reprint author), Ctr Dis Control & Prevent, Battelle Mem Inst, 4770 Buford Hwy NE,MS F50, Atlanta, GA 30341 USA.
EM JBarr@cdc.gov
FU Public Health Service [AI059348, AI061200]; Centers for Disease Control
and Prevention, Coordinating Office for Terrorism Preparedness and
Emergency Response
FX This study was supported in part by Public Health Service grants
AI059348 (T. R. K. and A. P.) and AI061200 (T. R. K. and A. P.). The
research described in this publication was supported by funds made
available from the Centers for Disease Control and Prevention,
Coordinating Office for Terrorism Preparedness and Emergency Response.
NR 50
TC 39
Z9 39
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD AUG
PY 2009
VL 77
IS 8
BP 3432
EP 3441
DI 10.1128/IAI.00346-09
PG 10
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 471ZX
UT WOS:000268098400034
PM 19506008
ER
PT J
AU Gaynes, RP
Gould, CV
Edwards, J
Antoine, TL
Blumberg, HM
DeSilva, K
King, M
Kraman, A
Pack, J
Ribner, B
Seybold, U
Steinberg, J
Jernigan, JA
AF Gaynes, Robert P.
Gould, Carolyn V.
Edwards, Jonathan
Antoine, Theresa L.
Blumberg, Henry M.
DeSilva, Kathryn
King, Mark
Kraman, Alice
Pack, Jan
Ribner, Bruce
Seybold, Ulrich
Steinberg, James
Jernigan, John A.
TI A Multicenter Study on Optimizing Piperacillin-Tazobactam Use: Lessons
on Why Interventions Fail
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; DECISION-SUPPORT
AB We examined interventions to optimize piperacillin-tazobactam use at 4 hospitals. Interventions for rotating house staff did not affect use. We could target empiric therapy in only 35% of cases. Because prescribing practices seemed to be institution specific, interventions should address attitudes of local prescribers. Interventions should target empiric therapy and ordering of appropriate cultures.
C1 [Gaynes, Robert P.; Gould, Carolyn V.; Edwards, Jonathan; Antoine, Theresa L.; Jernigan, John A.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
[Gaynes, Robert P.; Gould, Carolyn V.; Blumberg, Henry M.; King, Mark; Ribner, Bruce; Steinberg, James; Jernigan, John A.] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA.
[Gaynes, Robert P.; DeSilva, Kathryn] Atlanta Vet Affairs Med Ctr, Atlanta, GA USA.
[Blumberg, Henry M.; King, Mark] Grady Mem Hosp, Dept Epidemiol, Atlanta, GA USA.
[Kraman, Alice; Steinberg, James] Emory Crawford Long Hosp, Atlanta, GA USA.
[Pack, Jan; Ribner, Bruce] Emory Univ Hosp, Atlanta, GA 30322 USA.
[Seybold, Ulrich] Univ Munich, Med Poliklin, D-8000 Munich, Germany.
RP Gaynes, RP (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE,Mailstop A-24, Atlanta, GA 30333 USA.
EM rgaynes@cdc.gov
OI Hemenway, Alice/0000-0002-2363-4431
FU Centers for Disease Control and Prevention
FX Financial support. Centers for Disease Control and Prevention.
NR 8
TC 2
Z9 2
U1 0
U2 0
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0899-823X
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD AUG
PY 2009
VL 30
IS 8
BP 794
EP 796
DI 10.1086/599002
PG 3
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 469LD
UT WOS:000267898800014
PM 19530943
ER
PT J
AU Logan, JE
AF Logan, J. E.
TI Prevention factors for suicide ideation among abused pre/early
adolescent youths
SO INJURY PREVENTION
LA English
DT Article
ID PROTECTIVE-FACTORS; RISK; VICTIMIZATION; DEPRESSION
AB Suicide ideation is a problem among youths who have been previously abused. This study assesses whether three factors (ie, feeling connected to school, having parents who reward good behaviour, and feeling able to cope with peer conflict) are negatively associated with suicidal ideation for 2598 pre/early adolescents with various levels of prior abuse. For the entire youth population, those who reported all three factors were less than half as likely to have suicidal thoughts as those who did not report any of these factors (10.8% vs 30.3%, p<0.05). This pattern was similar and significant for youths who experienced peer abuse (10.2% vs 35.0%, p<0.05) and youths who experienced both early child abuse and peer abuse (21.6% vs 54.8%, p<0.05). Comprehensive programmes that improve school connectedness, parent-child relationships and coping skills to avoid violent peer conflicts may help decrease suicide ideation among youths, particularly those who have been previously abused.
C1 Ctr Dis Control & Prevent, Etiol & Surveillance Branch, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA.
RP Logan, JE (reprint author), Ctr Dis Control & Prevent, Etiol & Surveillance Branch, Div Violence Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway,MS-F63, Atlanta, GA 30341 USA.
EM ffa3@cdc.gov
FU Centers for Disease Control and Prevention
FX Centers for Disease Control and Prevention.
NR 11
TC 10
Z9 10
U1 1
U2 4
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1353-8047
J9 INJURY PREV
JI Inj. Prev.
PD AUG
PY 2009
VL 15
IS 4
BP 278
EP 280
DI 10.1136/ip.2008.020966
PG 3
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 478OZ
UT WOS:000268598900015
PM 19652004
ER
PT J
AU Okot-Chono, R
Mugisha, F
Adatu, F
Madraa, E
Dlodlo, R
Fujiwara, P
AF Okot-Chono, R.
Mugisha, F.
Adatu, F.
Madraa, E.
Dlodlo, R.
Fujiwara, P.
TI Health system barriers affecting the implementation of collaborative
TB-HIV services in Uganda
SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
LA English
DT Article
DE tuberculosis; collaboration; HIV/AIDS barriers
ID TUBERCULOSIS PATIENTS; CARE; EPIDEMIC
AB SETTING: Despite Uganda's efforts to improve tuberculosis and human immunodeficiency virus (TB-HIV) collaborative services, implementation remains low and operational barriers have not been systematically identified and documented.
OBJECTIVE: To assess barriers to implementation of TB-HIV collaborative services in five districts in Uganda.
DESIGN: In this qualitative study, focus groups and key informant and in-depth interviews were conducted for patients (HIV, TB), health providers and community members. TB registers were also assessed for data on use of TB-HIV collaborative services.
RESULTS: Of 333 adult TB patients registered between July and September 2006, 185 (56%) were tested for HIV, of whom 1.34 were HIV-co-infected. Of these, 52% were on cotrimoxazole preventive therapy (CPT), 12% were on antiretroviral therapy (ART) and CPT, while 36% had not received any HIV service. Health system barriers identified included poor TB-HIV planning, coordination and leadership, inadequate dissemination of policy, inadequate provider knowledge, limited TB-HIV interclinic referral, poor service integration and recording, logistical shortages, high costs of services and provider shortages amidst high patient loads.
CONCLUSION: Implementation and utilisation of collaborative TB-HIV services remains suboptimal. The barriers identified highlight the need for TB and HIV programmes to support districts to plan, coordinate and invest resources in TB-HIV collaborative services, especially in policy dissemination, training health providers, integration of TB-HIV services, logistical management and monitoring.
C1 [Okot-Chono, R.; Dlodlo, R.; Fujiwara, P.] Int Union TB & Lung Dis, Paris, France.
[Mugisha, F.] Reg Ctr Qual Hlth Care, Kampala, Uganda.
[Adatu, F.] Natl TB & Leprosy Programme, Kampala, Uganda.
[Madraa, E.] Natl AIDS Control Programme, Kampala, Uganda.
[Fujiwara, P.] US Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Okot-Chono, R (reprint author), Int Union TB & Lung Dis HIV, POB 16094, Kampala 256, Uganda.
EM rokotchono@theunion.org
NR 24
TC 24
Z9 24
U1 0
U2 1
PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
PI PARIS
PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE
SN 1027-3719
J9 INT J TUBERC LUNG D
JI Int. J. Tuberc. Lung Dis.
PD AUG
PY 2009
VL 13
IS 8
BP 955
EP 961
PG 7
WC Infectious Diseases; Respiratory System
SC Infectious Diseases; Respiratory System
GA 477JW
UT WOS:000268516300006
PM 19723374
ER
PT J
AU Oster, AM
Sullivan, PS
Blair, JM
AF Oster, Alexandra M.
Sullivan, Patrick S.
Blair, Janet M.
TI Prevalence of Cervical Cancer Screening of HIV-Infected Women in the
United States
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article; Proceedings Paper
CT 16th Conference on Retroviruses and Opportunistic Infections
CY FEB 08-11, 2009
CL Montreal, CANADA
DE HIV infections/complications; mass screening; uterine cervical
dysplasia/diagnosis; uterine cervical neoplasms/diagnosis; vaginal
smears
ID HUMAN-IMMUNODEFICIENCY-VIRUS; SQUAMOUS INTRAEPITHELIAL LESIONS;
HUMAN-PAPILLOMAVIRUS INFECTION; PAPANICOLAOU SMEARS; RISK-FACTORS;
SELF-REPORT; PAP-SMEAR; NEOPLASIA; ACCURACY; RECOMMENDATIONS
AB Background: HIV-infected women are at increased risk of cervical cytologic abnormalities. HIV treatment guidelines recommend annual Papanicolaou (Pap) tests for HIV-infected women. We assessed screening prevalence and associated factors among HIV-infected women.
Methods: We used data collected during 2000-2004 in an interview study of HIV-infected persons in 18 states. We performed logistic regression to describe factors associated with not having an annual Pap test.
Results: Of 2417 women, 556 (23.0%) did not report receiving a Pap test during the past year. Not having a Pap test was associated with increasing age [adjusted odds ratio (AOR) = 1.3 per 10 years, 95% confidence interval (CI): 1.1 to 1.4] and most recent CD4 count of <200 cells per microliter (AOR = 1.6, CI: 1.1 to 2.1) or unknown (AOR = 1.4, CI: 1.1 to 1.7; both vs. CD4 Count of >= 200 cells/mu L). Odds of a missed Pap test increased for women whose most recent pelvic exam was not performed at their usual source of HIV care (AOR = 2.6, CI: 2.1 to 3.2).
Conclusions: Nearly 1 in 4 women did not receive an annual Pap test. HIV care providers should ensure that HIV-infected women receive annual Pap tests, recognizing that missed Pap tests are more likely among older women and women with low CD4 cell counts. Integrating HIV and gynecologic care and educating clinicians about recommendations may increase screening.
C1 [Oster, Alexandra M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA.
[Oster, Alexandra M.; Sullivan, Patrick S.; Blair, Janet M.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
[Sullivan, Patrick S.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
RP Oster, AM (reprint author), 1600 Clifton Rd NE,MS E-46, Atlanta, GA 30333 USA.
EM aoster@cdc.gov
OI Sullivan, Patrick/0000-0002-7728-0587
NR 32
TC 31
Z9 31
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD AUG 1
PY 2009
VL 51
IS 4
BP 430
EP 436
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 470RJ
UT WOS:000267997100009
PM 19474756
ER
PT J
AU Uy, J
Armon, C
Buchacz, K
Wood, K
Brooks, JT
AF Uy, Jonathan
Armon, Carl
Buchacz, Kate
Wood, Kathy
Brooks, John T.
CA HOPS Investigators
TI Initiation of HAART at Higher CD4 Cell Counts Is Associated With a Lower
Frequency of Antiretroviral Drug Resistance Mutations at Virologic
Failure
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article; Proceedings Paper
CT 4th International-AIDS-Society Conference on HIV Pathogenesis, Treatment
and Prevention
CY JUL 22-25, 2007
CL Sydney, AUSTRALIA
SP Int AIDS Soc
DE genotype; HIV; viral drug resistance
ID HIV-1-INFECTED PATIENTS; COLLABORATIVE ANALYSIS; THERAPY; HIV; COHORT;
RISK
AB Background: There are limited data on the risk of developing HIV drug resistance based on the CD4 cell count at which highly active antiretroviral therapy (HAART) is initiated.
Methods: We examined data from participants in the HIV Outpatient Study who initiated antiretroviral therapy with HAART in 1999 or later (when genotypic resistance testing became more commonly used in clinical practice and in the HIV Outpatient Study), achieved virologic suppression, and subsequently experienced virologic failure and received a genotypic assay for antiretroviral resistance mutations. We assessed the frequency of resistance mutations at virologic failure and the differences in the frequencies of mutations by the CD4 stratum at which HAART was initiated using the Cochran-Armitage exact test.
Results: Of 683 patients who achieved virologic suppression on a first HAART regimen, 243 had virologic failure and 78 of these had a genotype resistance test done. Among these patients, the frequency of any HIV resistance mutations was 50% among patients who started HAART at 0-199 CD4 cells per cubic millimeter or 200-349 CD4 cells per cubic millimeter compared with 22% among patients who started HAART at; >= 350 CD4 cells per cubic millimeter (P = 0.062). The frequency of nucleoside reverse transcriptase inhibitor-associated mutations was 48%, 31%, and 11% among persons who initiated nucleoside reverse transcriptase inhibitor-containing HAART within these respective CD4 cell count strata (P = 0.005). We observed similar trends for nonnucleoside reverse transcriptase inhibitor-associated (P = 0.040) and protease inhibitor-associated (P = 0.063) mutations among persons initiating HAART containing these agents.
Conclusions: Patients failing HAART that was initiated at <350 CD4 cells per cubic millimeter had higher frequencies of resistance mutations to the classes of antiretrovirals to which they had been exposed than failing patients who initiated at >= 350 CD4 cells per cubic millimeter. Initiating HAART at higher CD4 cell counts may decrease the risk of developing treatment-limiting antiretroviral resistance.
C1 [Uy, Jonathan] Univ Illinois, Chicago, IL USA.
[Armon, Carl; Wood, Kathy] Cerner Corp, Vienna, VA USA.
[Buchacz, Kate; Brooks, John T.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA.
RP Uy, J (reprint author), Bristol Myers Squibb Co, Virol Med Strategy, 777 Scudders Mill Rd, Plainsboro, NJ 08536 USA.
EM jonathan.uy@bms.com
NR 10
TC 35
Z9 37
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD AUG 1
PY 2009
VL 51
IS 4
BP 450
EP 453
PG 4
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 470RJ
UT WOS:000267997100012
PM 19474757
ER
PT J
AU Khan, MR
Bolyard, M
Sandoval, M
Mateu-Gelabert, P
Krauss, B
Aral, SO
Friedman, SR
AF Khan, Maria R.
Bolyard, Melissa
Sandoval, Milagros
Mateu-Gelabert, Pedro
Krauss, Beatrice
Aral, Sevgi O.
Friedman, Samuel R.
TI Social and Behavioral Correlates of Sexually Transmitted Infection- and
HIV-Discordant Sexual Partnerships in Bushwick, Brooklyn, New York
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article; Proceedings Paper
CT 28th International Sunbelt Social Network Conference
CY JAN 26, 2008
CL St Pete Beach, FL
DE Bushwick; discordant partnerships; HIV; sexual behavior; sexually
transmitted infections; social factors; substance use
ID UNITED-STATES; MIXING PATTERNS; AMERICAN ADOLESCENTS; RISK BEHAVIORS;
YOUNG-ADULTS; PREVALENCE; WOMEN; PREVENTION; NETWORKS; DISEASES
AB Introduction: The Centers for Disease Control and Prevention (CDC) advise repeat HIV testing for partners of HIV-infected persons; injection drug users and their sex partners; individuals with recent multiple partnerships and their sex partners; those involved in sex trade; and men who have sex with men. Additional social and behavioral variables may be useful for identifying priority populations.
Methods: We analyzed data collected during a social network study conducted in a Brooklyn, NY, neighborhood to identify social and behavioral characteristics of respondents (N = 343) involved in HIV-discordant, herpes simplex virus-2- discordant, and chlamydia-discordant partnerships.
Results: HIV partnership discordance was associated with injection drug use but was generally not associated with sexual behaviors including multiple partnerships and sex trade. herpes simplex virus-2 and chlamydia partnership discordance were associated with multiple partnerships, sex trade, and same sex partnership history. Additional correlates of sexually transmitted infection (STI)/HIV-discordant partnerships included older age (>= 25 years), noninjection drug use, and incarceration history. Analyses suggested that screening tools composed of CDC-recommended sexual risk and injection drug indicators plus indicators of older age, noninjection drug use, and incarceration were more effective in identifying STI/HIV priority populations than tools composed of CDC indicators alone.
Conclusions: Screening tools that include social and behavioral indicators may improve STI/HIV case-finding effectiveness.
C1 [Khan, Maria R.; Sandoval, Milagros; Mateu-Gelabert, Pedro; Friedman, Samuel R.] Natl Dev & Res Inst Inc, New York, NY 10010 USA.
[Khan, Maria R.] Publ Hlth Solut, New York, NY USA.
[Bolyard, Melissa] Emory Coll Arts & Sci, Atlanta, GA USA.
[Krauss, Beatrice] CUNY Hunter, Ctr AIDS Drugs & Community Hlth, New York, NY USA.
[Aral, Sevgi O.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Khan, MR (reprint author), Natl Dev & Res Inst Inc, 71 W 23rd St, New York, NY 10010 USA.
EM maria_khan@unc.edu
FU NIDA NIH HHS [5T32 DA07233, R01 DA013128, R01DA013128, T32 DA007233]
NR 45
TC 8
Z9 10
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD AUG 1
PY 2009
VL 51
IS 4
BP 470
EP 485
PG 16
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 470RJ
UT WOS:000267997100016
PM 19458533
ER
PT J
AU Lambert, AJ
Lanciotti, RS
AF Lambert, Amy J.
Lanciotti, Robert S.
TI Consensus Amplification and Novel Multiplex Sequencing Method for S
Segment Species Identification of 47 Viruses of the Orthobunyavirus,
Phlebovirus, and Nairovirus Genera of the Family Bunyaviridae
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID TRANSCRIPTASE-PCR ASSAY; WEST-NILE-VIRUS; HEMORRHAGIC-FEVER;
ENCEPHALITIS VIRUSES; RAPID DETECTION; REASSORTANT; BUNYAMWERA;
OUTBREAKS; DISEASE; SAMPLES
AB A reverse transcription-PCR (RT-PCR) assay was designed, according to previously determined and newly derived genetic data, to target S genomic segments of 47 viruses, including 29 arthropod-borne human pathogens, of the family Bunyaviridae. The analytical sensitivity of the presented assay was evaluated through its application to RNAs extracted from quantitated dilutions of bunyaviruses of interest. Additionally, the assay's analytical specificity was determined through the evaluation of RNAs extracted from selected bunyaviruses and other representative arthropod-borne viruses isolated from a diverse group of host species and temporal and geographic origins. After RT-PCR amplification, DNAs amplified from bunyaviruses of interest were subjected to a novel multiplex sequencing method to confirm bunyavirus positivity and provide preliminary, species-level S segment identification. It is our goal that this assay will be used as a tool for identification and characterization of emergent arthropod-borne bunyavirus isolates of medical import as well as related viruses of the family Bunyaviridae that have not been associated with human illness.
C1 [Lambert, Amy J.; Lanciotti, Robert S.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Publ Hlth Serv,US Dept HHS, Ft Collins, CO USA.
RP Lambert, AJ (reprint author), CDC, Div Vector Borne Infect Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Rampart Rd, Ft Collins, CO 80521 USA.
EM ahk7@cdc.gov
NR 31
TC 35
Z9 37
U1 0
U2 8
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD AUG
PY 2009
VL 47
IS 8
BP 2398
EP 2404
DI 10.1128/JCM.00182-09
PG 7
WC Microbiology
SC Microbiology
GA 477DV
UT WOS:000268499600007
PM 19535518
ER
PT J
AU Tenover, FC
Gay, EA
Frye, S
Eells, SJ
Healy, M
McGowan, JE
AF Tenover, Fred C.
Gay, Emily A.
Frye, Stacie
Eells, Samantha J.
Healy, Mimi
McGowan, John E., Jr.
TI Comparison of Typing Results Obtained for Methicillin-Resistant
Staphylococcus aureus Isolates with the DiversiLab System and
Pulsed-Field Gel Electrophoresis
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID SEQUENCE-BASED PCR; UNITED-STATES; STRAIN DIFFERENTIATION;
IDENTIFICATION; INFECTIONS; DATABASE
AB We compared the results of typing methicillin-resistant Staphylococcus aureus (MRSA) isolates using the DiversiLab system (DL) to the results obtained using pulsed-field gel electrophoresis (PFGE). One hundred five MRSA isolates of PFGE types USA100 to USA1100 and the Brazilian clone, from the Centers for Disease Control and Prevention (CDC) and Project ICARE strain collections, were typed using DL. In addition, four unique sets of MRSA isolates from purported MRSA outbreaks that had been previously typed by DL, each consisting of six isolates (where five isolates were classified as indistinguishable by DL and one was an unrelated DL type) were typed by PFGE. DL separated the 105 MRSA isolates of known USA types into 11 clusters and six unique banding patterns. DL grouped most of the USA100, USA200, and USA1100 isolates into unique clusters. Multilocus sequence type 8 isolates (i.e., USA300 and USA500) often clustered together at > 95% similarity in DL dendrograms. Nevertheless, USA300 and USA500 DL patterns could be distinguished using the pattern overlay function of the DL software. Among the hospital outbreak clusters, PFGE and DL identified the same "unrelated" organism in three of four sets. However, PFGE showed more pattern diversity than did DL, suggesting that two of the sets were less likely to represent true outbreaks. In summary, DL is useful for screening MRSA isolates to rule out potential outbreaks of MRSA in hospitals, but PFGE provides better discrimination of potential outbreak strains and is more useful for confirming strain relatedness and specific USA types.
C1 [McGowan, John E., Jr.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
[Tenover, Fred C.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Frye, Stacie; Healy, Mimi] Bacterial Barcodes Inc, Athens, GA USA.
RP McGowan, JE (reprint author), Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, 1518 Clifton Rd NE, Atlanta, GA 30322 USA.
EM jmcgowa@emory.edu
RI mcgowan jr, john/G-5404-2011
FU Astra-Zeneca Pharmaceuticals, Wilmington, DE; Elan Pharmaceuticals, San
Diego, CA; Johnson & Johnson Pharmaceutical Research & Development, LLC,
Raritan, NJ; Pfizer Incorporated, New York, NY; 3M Health Care Products,
St. Paul, MN
FX Phase 5 of Project ICARE was supported in part by unrestricted research
grants to the Rollins School of Public Health of Emory University by
Astra-Zeneca Pharmaceuticals, Wilmington, DE; Elan Pharmaceuticals, San
Diego, CA; Johnson & Johnson Pharmaceutical Research & Development, LLC,
Raritan, NJ; Pfizer Incorporated, New York, NY; and 3M Health Care
Products, St. Paul, MN.
NR 18
TC 52
Z9 54
U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD AUG
PY 2009
VL 47
IS 8
BP 2452
EP 2457
DI 10.1128/JCM.00476-09
PG 6
WC Microbiology
SC Microbiology
GA 477DV
UT WOS:000268499600014
PM 19553588
ER
PT J
AU Kozak, NA
Benson, RF
Brown, E
Alexander, NT
Taylor, TH
Shelton, BG
Fields, BS
AF Kozak, Natalia A.
Benson, Robert F.
Brown, Ellen
Alexander, Nicole T.
Taylor, Thomas H., Jr.
Shelton, Brian G.
Fields, Barry S.
TI Distribution of lag-1 Alleles and Sequence-Based Types among Legionella
pneumophila Serogroup 1 Clinical and Environmental Isolates in the
United States
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID MONOCLONAL-ANTIBODIES; LEGIONNAIRES-DISEASE; DISCRIMINATORY ABILITY;
SCHEME; LIPOPOLYSACCHARIDE; STRAINS; POPULATION; SUBGROUPS; OUTBREAK;
PATTERNS
AB Approximately 84% of legionellosis cases are due to Legionella pneumophila serogroup 1. Moreover, a majority of L. pneumophila serogroup 1 clinical isolates react positively with monoclonal antibody 2 (MAb2) of the international standard panel. Over 94% of the legionellosis outbreaks investigated by the Centers for Disease Control and Prevention are due to this subset of L. pneumophila serogroup 1. To date, there is no complete explanation for the enhanced ability of these strains to cause disease. To better characterize these organisms, we subtyped 100 clinical L. pneumophila serogroup 1 isolates and 50 environmental L. pneumophila serogroup 1 isolates from the United States by (i) reactivity with MAb2, (ii) presence of a lag-1 gene required for the MAb2 epitope, and (iii) sequence-based typing analysis. Our results showed that the MAb2 epitope and lag-1 gene are overrepresented in clinical L. pneumophila serogroup 1 isolates. MAb2 recognized 75% of clinical isolates but only 6% of environmental isolates. Similarly, 75% of clinical isolates but only 8% of environmental isolates harbored lag-1. We identified three distinct lag-1 alleles, referred to as Philadelphia, Arizona, and Lens alleles, among 79 isolates carrying this gene. The Arizona allele is described for the first time in this study. We identified 59 different sequence types (STs), and 34 STs (58%) were unique to the United States. Our results support the hypothesis that a select group of STs may have an enhanced ability to cause legionellosis. Combining sequence typing and lag-1 analysis shows that STs tend to associate with a single lag-1 allele type, suggesting a hierarchy of virulence genotypes. Further analysis of ST and lag-1 profiles may identify genotypes of L. pneumophila serogroup 1 that warrant immediate intervention.
C1 [Kozak, Natalia A.; Benson, Robert F.; Brown, Ellen; Alexander, Nicole T.; Taylor, Thomas H., Jr.; Fields, Barry S.] Ctr Dis Control & Prevent, Coordinating Ctr Infect Dis, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, Atlanta, GA 30033 USA.
[Shelton, Brian G.] PathCon Labs, Norcross, GA 30092 USA.
RP Kozak, NA (reprint author), Ctr Dis Control & Prevent, Coordinating Ctr Infect Dis, Natl Ctr Immunizat & Resp Dis, Div Bacterial Dis, 1600 Clifton Rd NE,Mail Stop G03, Atlanta, GA 30033 USA.
EM htv2@cdc.gov
NR 41
TC 39
Z9 41
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD AUG
PY 2009
VL 47
IS 8
BP 2525
EP 2535
DI 10.1128/JCM.02410-08
PG 11
WC Microbiology
SC Microbiology
GA 477DV
UT WOS:000268499600026
PM 19553574
ER
PT J
AU Satola, SW
Caliendo, AM
Farley, MM
Patel, JB
Burd, EM
AF Satola, Sarah W.
Caliendo, Angela M.
Farley, Monica M.
Patel, Jean B.
Burd, Eileen M.
TI Lack of Heteroresistance among Staphylococcus aureus Isolates with
Vancomycin MICs of 2 Micrograms per Milliliter by Automated Testing
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Letter
ID POPULATION ANALYSIS; RESISTANT
C1 [Satola, Sarah W.; Caliendo, Angela M.; Burd, Eileen M.] Emory Univ, Sch Med, Atlanta, GA 30322 USA.
[Farley, Monica M.] Atlanta Vet Affairs Med Ctr, Decatur, GA USA.
[Patel, Jean B.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA.
RP Satola, SW (reprint author), Emory Univ, Sch Med, Atlanta, GA 30322 USA.
EM ssatola@emory.edu
NR 5
TC 6
Z9 6
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD AUG
PY 2009
VL 47
IS 8
BP 2680
EP 2681
DI 10.1128/JCM.01184-09
PG 2
WC Microbiology
SC Microbiology
GA 477DV
UT WOS:000268499600061
PM 19553587
ER
PT J
AU Cox, PJ
AF Cox, Pamela J.
TI BRIEF REPORT OF COMMUNITY OWNERSHIP OF LOCAL COALITIONS: COMMUNITY
MEMBERS' PERSPECTIVES
SO JOURNAL OF COMMUNITY PSYCHOLOGY
LA English
DT Article
ID PERCEIVED OWNERSHIP; HEALTH
AB Although community ownership has been described as critical to the long-term effectiveness of local coalitions, a lack of consensus exists regarding what community ownership is and what exactly is being owned. This exploratory study examined community ownership of coalitions that address domestic violence from the perspective of community members who initiated and operated these coalitions. Qualitative data collection methods included interviews, observations, and archival review of coalition records. Findings expand current conceptualizations of what community ownership is and how it develops. Results may inform future research regarding how community ownership affects the effectiveness of a coalition's programs and how researchers and government agencies partner with coalitions to address health problems. (C) 2009 Wiley Periodicals, Inc.
C1 Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
RP Cox, PJ (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE,Mailstop F-64, Atlanta, GA 30341 USA.
EM pcox@cdc.gov
NR 7
TC 0
Z9 0
U1 0
U2 2
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0090-4392
J9 J COMMUNITY PSYCHOL
JI J. Community Psychol.
PD AUG
PY 2009
VL 37
IS 6
BP 789
EP 794
DI 10.1002/jcop.20319
PG 6
WC Public, Environmental & Occupational Health; Psychology,
Multidisciplinary; Social Work
SC Public, Environmental & Occupational Health; Psychology; Social Work
GA 472SD
UT WOS:000268151500010
ER
PT J
AU Ma, L
Zhang, GD
Gerner-Smidt, P
Mantripragada, V
Ezeoke, I
Doyle, MP
AF Ma, Li
Zhang, Guodong
Gerner-Smidt, Peter
Mantripragada, Vijaya
Ezeoke, Ifeoma
Doyle, Michael P.
TI Thermal Inactivation of Salmonella in Peanut Butter
SO JOURNAL OF FOOD PROTECTION
LA English
DT Article
ID LISTERIA-MONOCYTOGENES; HEAT TOLERANCE; BEEF; TYPHIMURIUM; VALIDATION;
SEROVARS; CHICKEN; TURKEY; SPP.
AB The objective of this study was to determine the rates of thermal inactivation of three Salmonella Tennessee strains in peanut butter associated with an outbreak and to compare them to the rates of inactivation of Salmonella strains of other serotypes (Enteritidis, Typhimurium, and Heidelberg) (SSOS) and of clinical isolates of Salmonella Tennessee from sporadic cases (STSC). Commercial peanut butter was inoculated with Salmonella isolates and heated at 71, 77, 83, and 90 degrees C. The thermal inactivation curves were upwardly concave, indicating rapid death at the beginning (20 min) of heating followed by lower death rates thereafter. The first-order kinetics approach and nonlinear Weibull model were used to fit the inactivation curves and describe the rates of thermal inactivation of Salmonella in peanut butter. The calculated minimum times needed to obtain a 7-log reduction at 90 degrees C for the composited three outbreak-associated strains were significantly greater (P < 0.05) than those of SSOS and STSC. Approximately 120 min were needed to reduce the outbreak strains of Salmonella Tennessee by 7 log, whereas 86 and 55 min were needed for SSOS and STSC, respectively. These results indicate that the outbreak-associated Salmonella strains were more thermotolerant than the other Salmonella strains tested, and this greater thermal resistance was not serotype specific. Thermal treatments of peanut butter at 90 degrees C for less than 30 min are not sufficient to kill large populations (5 log CFU/g) of Salmonella in highly contaminated peanut butter.
C1 [Ma, Li; Zhang, Guodong; Mantripragada, Vijaya; Ezeoke, Ifeoma; Doyle, Michael P.] Univ Georgia, Ctr Food Safety, Griffin, GA 30223 USA.
[Gerner-Smidt, Peter] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Doyle, MP (reprint author), Univ Georgia, Ctr Food Safety, Griffin, GA 30223 USA.
EM mdoyle@uga.edu
NR 13
TC 48
Z9 51
U1 6
U2 43
PU INT ASSOC FOOD PROTECTION
PI DES MOINES
PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2863 USA
SN 0362-028X
J9 J FOOD PROTECT
JI J. Food Prot.
PD AUG
PY 2009
VL 72
IS 8
BP 1596
EP 1601
PG 6
WC Biotechnology & Applied Microbiology; Food Science & Technology
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 483DH
UT WOS:000268941700001
PM 19722389
ER
PT J
AU Kirkland, E
Green, LR
Stone, C
Reimann, D
Nicholas, D
Mason, R
Frick, R
Coleman, S
Bushnell, L
Blade, H
Radke, V
Selman, C
AF Kirkland, Elizabeth
Green, Laura R.
Stone, Carmily
Reimann, Dave
Nicholas, Dave
Mason, Ryan
Frick, Roberta
Coleman, Sandra
Bushnell, Lisa
Blade, Henry
Radke, Vincent
Selman, Carol
CA EHS-NET Working Grp
TI Tomato Handling Practices in Restaurants
SO JOURNAL OF FOOD PROTECTION
LA English
DT Article
ID UNITED-STATES; SALMONELLA INFECTIONS; RAW TOMATOES; OUTBREAKS
AB In recent years, multiple outbreaks of Salmonella infection have been associated with fresh tomatoes. Investigations have indicated that tomato contamination likely occurred early in the farm-to-consumer chain, although tomato consumption occurred mostly in restaurants. Researchers have hypothesized that tomato handling practices in restaurants may contribute to these outbreaks. However, few empirical data exist on how restaurant workers handle tomatoes. This study was conducted to examine tomato handling practices in restaurants. Members of the Environmental Health Specialists Network (EHS-Net) observed tomato handling practices in 449 restaurants. The data indicated that handling tomatoes appropriately posed a challenge to many restaurants. Produce-only cutting boards were not used on 49% of tomato cutting observations, and gloves were not worn in 36% of tomato cutting observations. Although tomatoes were washed under running water as recommended in most (82%) of the washing observations, tomatoes were soaked in standing water, a practice not recommended by the U.S. Food and Drug Administration (FDA), in 18% of observations, and the temperature differential between the wash water and tomatoes did not meet FDA guidelines in 21% of observations. About half of all batches of cut tomatoes in holding areas were above 41 degrees F (5 degrees C), the temperature recommended by the FDA. The maximum holding time for most (73%) of the cut tomatoes held above 41 degrees F exceeded the FDA recommended holding time of 4 h for unrefrigerated tomatoes (i.e., tomatoes held above 41 degrees F). The information provided by this study can be used to inform efforts to develop interventions and thus prevent tomato-associated illness outbreaks.
C1 [Kirkland, Elizabeth; Green, Laura R.; Radke, Vincent; Selman, Carol; EHS-NET Working Grp] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Stone, Carmily] Iowa Dept Publ Hlth, Bur Enviromn Hlth Serv, Des Moines, IA 50319 USA.
[Reimann, Dave] Minnesota Dept Hlth, Mankato, MN 56001 USA.
[Nicholas, Dave] New York State Dept Hlth, Bur Community Environm Hlth & Food Protect, Troy, NY 12180 USA.
[Mason, Ryan] Metro Publ Hlth Dept, Food Div, Nashville, TN 37203 USA.
[Frick, Roberta] Calif Dept Publ Hlth, Richmond, CA 94808 USA.
[Coleman, Sandra] Georgia Div Publ Hlth, Dept Human Resources, Atlanta, GA 30303 USA.
[Bushnell, Lisa] Connecticut Dept Publ Hlth, Food Protect Program, Div Environm Hlth, Hartford, CT 06134 USA.
[Blade, Henry] Rhode Isl Dept Hlth, Off Food Protect, Providence, RI 02908 USA.
RP Green, LR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, MS F-28,4770 Buford Highway, Atlanta, GA 30341 USA.
EM lrg0@cdc.gov
FU CDC [CDC-RFA-EH05-013]
FX We thank Jack Guzewich and Shirley Bohm (FDA) for their assistance with
study design and data interpretation. This study was supported by states
receiving CDC grant awards funded under CDC-RFA-EH05-013.
NR 10
TC 7
Z9 7
U1 0
U2 4
PU INT ASSOC FOOD PROTECTION
PI DES MOINES
PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2863 USA
SN 0362-028X
J9 J FOOD PROTECT
JI J. Food Prot.
PD AUG
PY 2009
VL 72
IS 8
BP 1692
EP 1698
PG 7
WC Biotechnology & Applied Microbiology; Food Science & Technology
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 483DH
UT WOS:000268941700014
PM 19722402
ER
PT J
AU Logue, CH
Bosio, CF
Welte, T
Keene, KM
Ledermann, JP
Phillips, A
Sheahan, BJ
Pierro, DJ
Marlenee, N
Brault, AC
Bosio, CM
Singh, AJ
Powers, AM
Olson, KE
AF Logue, Christopher H.
Bosio, Christopher F.
Welte, Thomas
Keene, Kimberley M.
Ledermann, Jeremy P.
Phillips, Aaron
Sheahan, Brian J.
Pierro, Dennis J.
Marlenee, Nicole
Brault, Aaron C.
Bosio, Catharine M.
Singh, Amber J.
Powers, Ann M.
Olson, Ken E.
TI Virulence variation among isolates of western equine encephalitis virus
in an outbred mouse model
SO JOURNAL OF GENERAL VIROLOGY
LA English
DT Article
ID SEMLIKI-FOREST-VIRUS; ENCEPHALOMYELITIS VIRUS; SINDBIS VIRUS; GENOMIC
RNA; PATHOGENESIS; MICE; EASTERN; INFECTION; SEQUENCE; STRAINS
AB Little is known about viral determinants of virulence associated with western equine encephalitis virus (WEEV). Here, we have analysed six North American WEEV isolates in an outbred CD1 mouse model. Full genome sequence analyses showed <= 2.7% divergence among the six WEEV isolates. However, the percentage mortality and mean time to death (MTD) varied significantly when mice received subcutaneous injections of 10(3) p.f.u. of each virus. Two WEEV strains, McMillan (McM) and Imperial 181 (IMP), were the most divergent of the six in genome sequence; McM caused 100% mortality by 5 days post-infection, whereas IMP caused no mortality. McM had significantly higher titres in the brain than IMP. Similar differences in virulence were observed when McM and IMP were administered by aerosol, intranasal or intravenous routes. McM was 100% lethal with an MTD of 1.9 days when 10(3) p.f.u. of each virus was administered by intracerebral inoculation; in contrast, IMP caused no mortality. The presence of IMP in the brains after infection by different routes and the lack of observed mortality confirmed that IMP is neuroinvasive but not neurovirulent. Based on morbidity, mortality, MTD, severity of brain lesions, virus distribution patterns, routes of infection and differences in infection of cultured cells, McM and IMP were identified as high- and low-virulence isolates, respectively.
C1 [Logue, Christopher H.; Bosio, Christopher F.; Welte, Thomas; Phillips, Aaron; Pierro, Dennis J.; Marlenee, Nicole; Bosio, Catharine M.; Olson, Ken E.] Colorado State Univ, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA.
[Brault, Aaron C.] Univ Calif Davis, Ctr Vector Borne Dis, Davis, CA 95616 USA.
[Sheahan, Brian J.] Natl Univ Ireland Univ Coll Dublin, Vet Sci Ctr, Dublin 4, Ireland.
[Logue, Christopher H.; Keene, Kimberley M.; Ledermann, Jeremy P.; Singh, Amber J.; Powers, Ann M.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA.
RP Logue, CH (reprint author), Def Sci & Technol Lab, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England.
EM clogue@dstl.gov.uk
OI Sheahan, Brian Joseph/0000-0003-2952-4898
FU RMRCE [AI065357]
FX We thank Brooke A. Roeper of AIDL for her early preparatory help and Dr
Richard Bowen of the Rocky Mountain Regional Center for Excellence
(RMRCE) Animal Core for help with mouse studies and intracerebral
infections. Many thanks to Mark Delorey of the CDC Information
Technology Support office for help with the statistical analyses. This
work was supported by RMRCE grant AI065357.
NR 38
TC 26
Z9 26
U1 0
U2 1
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
BERKS, ENGLAND
SN 0022-1317
J9 J GEN VIROL
JI J. Gen. Virol.
PD AUG
PY 2009
VL 90
BP 1848
EP 1858
DI 10.1099/vir.0.008656-0
PG 11
WC Biotechnology & Applied Microbiology; Virology
SC Biotechnology & Applied Microbiology; Virology
GA 479YX
UT WOS:000268699400008
PM 19403754
ER
PT J
AU Damon, IK
Davidson, WB
Hughes, CM
Olson, VA
Smith, SK
Holman, RC
Frey, SE
Newman, F
Belshe, RB
Yan, LH
Karem, K
AF Damon, Inger K.
Davidson, Whitni B.
Hughes, Christine M.
Olson, Victoria A.
Smith, Scott K.
Holman, Robert C.
Frey, Sharon E.
Newman, Frances
Belshe, Robert B.
Yan, Lihan
Karem, Kevin
TI Evaluation of smallpox vaccines using variola neutralization
SO JOURNAL OF GENERAL VIROLOGY
LA English
DT Article
ID ANTIBODY-RESPONSES; VIRUS; VACCINATION; INFECTION; ANKARA;
IMMUNOGENICITY; PROTECTION; CHALLENGE; PROTEINS; IMMUNITY
AB The search for a 'third'-generation smallpox vaccine has resulted in the development and characterization of several vaccine candidates. A significant barrier to acceptance is the absence of challenge models showing induction of correlates of protective immunity against variola virus. In this light, virus neutralization provides one of few experimental methods to show specific 'in vitro' activity of vaccines against variola virus. Here, we provide characterization of the ability of a modified vaccinia. virus Ankara vaccine to induce variola. virus-neutralizing antibodies, and we provide comparison with the neutralization elicited by standard Dryvax vaccination.
C1 [Damon, Inger K.; Davidson, Whitni B.; Hughes, Christine M.; Olson, Victoria A.; Smith, Scott K.; Holman, Robert C.; Karem, Kevin] Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA.
[Frey, Sharon E.; Newman, Frances; Belshe, Robert B.] St Louis Univ, Sch Med, Div Infect Dis & Immunol, Edward A Doisy Res Ctr, St Louis, MO 63104 USA.
[Yan, Lihan] EMMES Corp, Rockville, MD 20850 USA.
RP Damon, IK (reprint author), Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Div Viral & Rickettsial Dis, 1600 Clifton Rd NE, Atlanta, GA 30333 USA.
EM iad7@cdc.gov
FU [N01-AI-25464]
FX The authors Would like to acknowledge the assistance of Mark Challberg
and Robert Johnson of DMID/NIAID for their assistance in facilitating
this study. The findings and conclusions in this report are those Of the
authors and do not necessarily reflect the views of the CDC. Funding:
N01-AI-25464.
NR 22
TC 24
Z9 24
U1 0
U2 3
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
BERKS, ENGLAND
SN 0022-1317
J9 J GEN VIROL
JI J. Gen. Virol.
PD AUG
PY 2009
VL 90
BP 1962
EP 1966
DI 10.1099/vir.0.010553-0
PG 5
WC Biotechnology & Applied Microbiology; Virology
SC Biotechnology & Applied Microbiology; Virology
GA 479YX
UT WOS:000268699400020
PM 19339477
ER
PT J
AU Griffin, JR
Holliday, RC
Frazier, E
Braithwaite, RL
AF Griffin, James R., Jr.
Holliday, Rhonda C.
Frazier, Emma
Braithwaite, Ronald L.
TI The BRAVE (Building Resiliency and Vocational Excellence) Program:
Evaluation Findings for a Career-Oriented Substance Abuse and Violence
Preventive Intervention
SO JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
LA English
DT Article
DE Substance abuse prevention; violence; resiliency; career development;
African American; mentoring; career goals
ID DRUG-USE; ADOLESCENTS; URBAN; SCHOOL; YOUTH; AGGRESSION; BEHAVIOR;
CHILDREN; ALCOHOL; MALES
AB This article examines the effectiveness of a career-oriented intervention for preventing involvement with alcohol, tobacco, and other drugs (ATODs) and violence and for promoting resilient behavior among eighth-grade, African American middle school students (N = 178; n = 92 intervention and n = 86 comparison) through the implementation of the Building Resiliency and Vocational Excellence (BRAVE) Program. Students were randomly assigned to either the intervention or control group. Students in the evaluation participated in the school-based BRAVE Program intervention and the standard public school curriculum. Comparison students participated only in the standard curriculum. Alcohol, tobacco, and other drug use and violent behavior were assessed for 178 students at baseline, post-test, and one-year follow up (one year after baseline). Results revealed a beneficial effect of the intervention on participants' frequency of use of alcohol (p<.04) and marijuana (p<.05), but no effect for violent behavior.
C1 [Griffin, James R., Jr.] Morehouse Sch Med, Dept Community Hlth & Prevent Med, Atlanta, GA 30310 USA.
[Holliday, Rhonda C.; Frazier, Emma; Braithwaite, Ronald L.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Behav & Clin Surveillance Branch, Atlanta, GA USA.
RP Griffin, JR (reprint author), Morehouse Sch Med, Dept Community Hlth & Prevent Med, 720 Westview Dr SW, Atlanta, GA 30310 USA.
EM jgriffin@msm.edu
NR 47
TC 12
Z9 12
U1 5
U2 14
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
21218-4363 USA
SN 1049-2089
J9 J HEALTH CARE POOR U
JI J. Health Care Poor Underserved
PD AUG
PY 2009
VL 20
IS 3
BP 798
EP 816
PG 19
WC Health Policy & Services; Public, Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA 473JT
UT WOS:000268203000017
PM 19648706
ER
PT J
AU Niska, R
Han, B
AF Niska, Richard
Han, Beth
TI The Use of Antiplatelet Agents for Secondary Prevention of Ischemic
Stroke in US Ambulatory Care Settings
SO JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Academy-of-Family-Physicians
CY SEP 27-30, 2006
CL Washington, DC
SP Amer Acad Family Phys
DE Antiplatelet agents; secondary prevention; ischemic stroke; ethnic
disparities; racial disparities
ID CARDIOVASCULAR-DISEASE; GUIDELINES; ATTACK; PROFESSIONALS; ASSOCIATION;
DISPARITIES; STATEMENT; COUNCIL; UPDATE
AB Introduction. We examined stroke prevention with antiplatelet agents by U.S. non-federal office physicians and hospital outpatient departments from 2005-2006. Methods. The nationally representative dataset used a multistage (112 primary sampling units, physicians/hospitals, patient medical records) random sample of 1,702 visits by patients 20 years or older with cerebrovascular disease (national estimate: 15.4 million annual visits). Dependent variable: use of antiplatelet agents for patients without contraindications. Independent variables: age, sex, race/ethnicity, payment, primary care provider, prior visits in last year, comorbidities. Logistic regression was used to investigate associations with recommended interventions. Results. Antiplatelet agents were prescribed at 31.1% of visits. Positive predictors: seeing the patient's primary care provider and having five or more comorbidities. Negative predictors: non-Hispanic Black race/ethnicity and having six or more prior visits in the last year. Conclusion. Variations by visit characteristics suggest that improvement in using antiplatelet agents is possible, especially for non-Hispanic Black patients.
C1 [Niska, Richard] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Atlanta, GA USA.
RP Niska, R (reprint author), 3311 Toledo Rd,Room 3319, Hyattsville, MD 20782 USA.
EM RNiska@cdc.gov
NR 18
TC 1
Z9 1
U1 0
U2 2
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
21218-4363 USA
SN 1049-2089
J9 J HEALTH CARE POOR U
JI J. Health Care Poor Underserved
PD AUG
PY 2009
VL 20
IS 3
BP 831
EP 839
PG 9
WC Health Policy & Services; Public, Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA 473JT
UT WOS:000268203000020
PM 19648709
ER
PT J
AU Kester, KE
Cummings, JF
Ofori-Anyinam, O
Ockenhouse, CF
Krzych, U
Moris, P
Schwenk, R
Nielsen, RA
Debebe, Z
Pinelis, E
Juompan, L
Williams, J
Dowler, M
Stewart, VA
Wirtz, RA
Dubois, MC
Lievens, M
Cohen, J
Ballou, WR
Heppner, DG
AF Kester, Kent E.
Cummings, James F.
Ofori-Anyinam, Opokua
Ockenhouse, Christian F.
Krzych, Urszula
Moris, Philippe
Schwenk, Robert
Nielsen, Robin A.
Debebe, Zufan
Pinelis, Evgeny
Juompan, Laure
Williams, Jack
Dowler, Megan
Stewart, V. Ann
Wirtz, Robert A.
Dubois, Marie-Claude
Lievens, Marc
Cohen, Joe
Ballou, W. Ripley
Heppner, D. Gray, Jr.
CA RTS
S Vaccine Evaluation Grp
TI Randomized, Double-Blind, Phase 2a Trial of Falciparum Malaria Vaccines
RTS,S/AS01B and RTS,S/AS02A in Malaria-Naive Adults: Safety, Efficacy,
and Immunologic Associates of Protection
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article; Proceedings Paper
CT 54th Annual Meeting of the
American-Society-for-Tropical-Medicine-and-Hygiene
CY DEC 11-15, 2005
CL Washington, DC
SP Amer Soc Trop Med & Hyg
ID CIRCUMSPOROZOITE PROTEIN VACCINE; INSTITUTE-OF-RESEARCH;
PLASMODIUM-FALCIPARUM; IMMUNOGENICITY; CHILDREN; ANTIGEN; RTS,S;
FORMULATIONS; RECOGNITION; INFECTION
AB Background. To further increase the efficacy of malaria vaccine RTS,S/AS02A, we tested the RTS, S antigen formulated using the AS01B Adjuvant System (GlaxoSmithKline Biologicals).
Methods. In a double-blind, randomized trial, 102 healthy volunteers were evenly allocated to receive RTS,S/AS01B or RTS,S/AS02A vaccine at months 0, 1, and 2 of the study, followed by malaria challenge. Protected vaccine recipients were rechallenged 5 months later.
Results. RTS,S/AS01B and RTS,S/AS02A were well tolerated and were safe. The efficacy of RTS,S/AS01B and RTS,S/AS02A was 50% (95% confidence interval [CI], 32.9%-67.1%) and 32% (95% CI, 17.6%-47.6%), respectively. At the time of initial challenge, the RTS, S/AS01B group had greater circumsporozoite protein (CSP)-specific immune responses, including higher immunoglobulin (Ig) G titers, higher numbers of CSP-specific CD4(+) T cells expressing >= 2 activation markers (interleukin-2, interferon [IFN]-gamma, tumor necrosis factor-alpha, or CD40L), and more ex vivo IFN-gamma enzyme-linked immunospots (ELISPOTs) than did the RTS,S/AS02A group. Protected vaccine recipients had a higher CSP-specific IgG titer (geometric mean titer, 188 vs 73 mg/mL; P <.001), higher numbers of CSP-specific CD4(+) T cells per 106 CD4(+) T cells (median, 963 vs 308 CSP-specific CD4(+) T cells/10(6) CD4(+) T cells; P <.001), and higher numbers of ex vivo IFN-gamma ELISPOTs (mean, 212 vs 96 spots/million cells; P <.001). At rechallenge, 4 of 9 vaccine recipients in each group were still completely protected.
Conclusions. The RTS,S/AS01B malaria vaccine warrants comparative field trials with RTS,S/AS02A to determine the best formulation for the protection of children and infants. The association between complete protection and immune responses is a potential tool for further optimization of protection.
C1 [Kester, Kent E.; Cummings, James F.; Ockenhouse, Christian F.; Krzych, Urszula; Schwenk, Robert; Nielsen, Robin A.; Debebe, Zufan; Pinelis, Evgeny; Juompan, Laure; Williams, Jack; Dowler, Megan; Stewart, V. Ann; Heppner, D. Gray, Jr.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Wirtz, Robert A.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Ofori-Anyinam, Opokua; Moris, Philippe; Dubois, Marie-Claude; Lievens, Marc; Cohen, Joe; Ballou, W. Ripley] GlaxoSmithKline Biol, Rixensart, Belgium.
RP Kester, KE (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM kent.kester@us.army.mil
RI Kester, Kent/A-2114-2011
OI Kester, Kent/0000-0002-5056-0802
NR 30
TC 217
Z9 221
U1 5
U2 23
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD AUG 1
PY 2009
VL 200
IS 3
BP 337
EP 346
DI 10.1086/600120
PG 10
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 465RH
UT WOS:000267604000004
PM 19569965
ER
PT J
AU Murphy, E
Andrew, L
Lee, KL
Dilts, DA
Nunez, L
Fink, PS
Ambrose, K
Borrow, R
Findlow, J
Taha, MK
Deghmane, AE
Kriz, P
Musilek, M
Kalmusova, J
Caugant, DA
Alvestad, T
Mayer, LW
Sacchi, CT
Wang, X
Martin, D
von Gottberg, A
du Plessis, M
Klugman, KP
Anderson, AS
Jansen, KU
Zlotnick, GW
Hoiseth, SK
AF Murphy, Ellen
Andrew, Lubomira
Lee, Kwok-Leung
Dilts, Deborah A.
Nunez, Lorna
Fink, Pamela S.
Ambrose, Karita
Borrow, Ray
Findlow, Jamie
Taha, Muhamed-Kheir
Deghmane, Ala-Eddine
Kriz, Paula
Musilek, Martin
Kalmusova, Jitka
Caugant, Dominique A.
Alvestad, Torill
Mayer, Leonard W.
Sacchi, Claudio T.
Wang, Xin
Martin, Diana
von Gottberg, Anne
du Plessis, Mignon
Klugman, Keith P.
Anderson, Annaliesa S.
Jansen, Kathrin U.
Zlotnick, Gary W.
Hoiseth, Susan K.
TI Sequence Diversity of the Factor H Binding Protein Vaccine Candidate in
Epidemiologically Relevant Strains of Serogroup B Neisseria meningitidis
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article; Proceedings Paper
CT 16th International Pathogenic Neisseria Conference
CY SEP, 2008
CL Rotterdam, NETHERLANDS
ID MENINGOCOCCAL DISEASE; UNITED-STATES; EVOLUTIONARY; LIPOPROTEIN;
PREVALENCE; VARIANTS; GNA1870; NADA
AB Background. Recombinant forms of Neisseria meningitidis human factor H binding protein (fHBP) are undergoing clinical trials in candidate vaccines against invasive meningococcal serogroup B disease. We report an extensive survey and phylogenetic analysis of the diversity of fhbp genes and predicted protein sequences in invasive clinical isolates obtained in the period 2000-2006.
Methods. Nucleotide sequences of fhbp genes were obtained from 1837 invasive N. meningitidis serogroup B (MnB) strains from the United States, Europe, New Zealand, and South Africa. Multilocus sequence typing (MLST) analysis was performed on a subset of the strains.
Results. Every strain contained the fhbp gene. All sequences fell into 1 of 2 subfamilies (A or B), with 60%-75% amino acid identity between subfamilies and at least 83% identity within each subfamily. One fHBP sequence may have arisen via inter-subfamily recombination. Subfamily B sequences were found in 70% of the isolates, and subfamily A sequences were found in 30%. Multiple fHBP variants were detected in each of the common MLST clonal complexes. All major MLST complexes include strains in both subfamily A and subfamily B.
Conclusions. The diversity of strains observed underscores the importance of studying the distribution of the vaccine antigen itself rather than relying on common epidemiological surrogates such as MLST.
C1 [Murphy, Ellen; Andrew, Lubomira; Lee, Kwok-Leung; Dilts, Deborah A.; Nunez, Lorna; Fink, Pamela S.; Ambrose, Karita; Anderson, Annaliesa S.; Jansen, Kathrin U.; Zlotnick, Gary W.; Hoiseth, Susan K.] Wyeth Vaccines Res, Pearl River, NY 10965 USA.
[Mayer, Leonard W.; Sacchi, Claudio T.; Wang, Xin] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Klugman, Keith P.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Borrow, Ray; Findlow, Jamie] Manchester Royal Infirm, Hlth Protect Agcy, Manchester M13 9WL, Lancs, England.
[Taha, Muhamed-Kheir; Deghmane, Ala-Eddine] Inst Pasteur, Invas Bacterial Infect Unit, Paris, France.
[Kriz, Paula; Musilek, Martin; Kalmusova, Jitka] Natl Inst Publ Hlth, Prague, Czech Republic.
[Caugant, Dominique A.; Alvestad, Torill] Norwegian Inst Publ Hlth, Oslo, Norway.
[Sacchi, Claudio T.] Inst Adolfo Lutz Registro, Sao Paulo, Brazil.
[Martin, Diana] Inst Environm Sci & Res, Porirua, New Zealand.
[von Gottberg, Anne; du Plessis, Mignon; Klugman, Keith P.] Natl Inst Communicable Dis, Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa.
RP Hoiseth, SK (reprint author), Wyeth Vaccines Res, 401 N Middletown Rd, Pearl River, NY 10965 USA.
EM hoiseths@wyeth.com
RI Krizova, Pavla/M-6120-2015
NR 40
TC 114
Z9 118
U1 0
U2 9
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD AUG 1
PY 2009
VL 200
IS 3
BP 379
EP 389
DI 10.1086/600141
PG 11
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 465RH
UT WOS:000267604000009
PM 19534597
ER
PT J
AU Butler, LM
Dorsey, G
Hladik, W
Rosenthal, PJ
Brander, C
Neilands, TB
Mbisa, G
Whitby, D
Kiepiela, P
Mosam, A
Mzolo, S
Dollard, SC
Martin, JN
AF Butler, Lisa M.
Dorsey, Grant
Hladik, Wolfgang
Rosenthal, Philip J.
Brander, Christian
Neilands, Torsten B.
Mbisa, Georgina
Whitby, Denise
Kiepiela, Photini
Mosam, Anisa
Mzolo, Similo
Dollard, Sheila C.
Martin, Jeffrey N.
TI Kaposi Sarcoma-Associated Herpesvirus (KSHV) Seroprevalence in
Population-Based Samples of African Children: Evidence for At Least 2
Patterns of KSHV Transmission
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article; Proceedings Paper
CT 14th Conference on Retroviruses and Opportunistic Infections
CY FEB 25-28, 2007
CL Los Angeles, CA
ID IMMUNODEFICIENCY-VIRUS TYPE-1; HIGHLY ENDEMIC AREA; HUMAN-HERPESVIRUS-8
INFECTION; BLOOD-TRANSFUSION; UGANDAN CHILDREN; RISK-FACTORS; VERTICAL
TRANSMISSION; SEXUAL TRANSMISSION; SEROLOGIC EVIDENCE; HHV-8 INFECTION
AB Background. Kaposi sarcoma-associated herpesvirus ( KSHV) infection is endemic among adult populations in Africa. A prevailing view is that childhood transmission is primarily responsible for the high seroprevalence of KSHV among adults that is observed throughout the continent. However, few studies have directly examined children, particularly in locations where KS is not commonly endemic.
Methods. Participants were children aged 1.5-8.9 years, including 427 children from a population-based sample in South Africa, 422 from a population-based sample in Uganda, and 567 from a clinic-based sample in Uganda. All serum specimens were tested by the same laboratory for KSHV antibodies with use of 2 enzyme immunoassays (against K8.1 and ORF65) and 1 immunofluorescence assay.
Results. KSHV seroprevalence was 7.5%-9.0% among South African children and was not associated with age. In contrast, in the Ugandan population-based sample, KSHV seroprevalence increased from 10% among 2-year-old children to 30.6% among 8-year-old children (P(trend) <.001). In the Ugandan clinic-based sample, sero-prevalence increased from 9.3% among 2-year-old children to 36.4% among 8-year-old children (P(trend) <.001). trend
Conclusion. Two distinct relationships between age and KSHV infection among children imply that KSHV transmission among children is not uniform throughout Africa and is therefore not always responsible for the high seroprevalence observed in adults. There are at least 2 patterns of KSHV transmission in Africa.
C1 [Butler, Lisa M.; Dorsey, Grant; Rosenthal, Philip J.; Neilands, Torsten B.; Martin, Jeffrey N.] Univ Calif San Francisco, San Francisco, CA 94105 USA.
[Hladik, Wolfgang; Dollard, Sheila C.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Brander, Christian] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Cambridge, MA 02138 USA.
[Brander, Christian] Inst Catalana Recerca & Estudis Avancats, Barcalona, Spain.
[Brander, Christian] Hosp Univ Germans Trias & Pujol, Inst Recerca Sida, Badalona, Catalonia, Spain.
[Mbisa, Georgina; Whitby, Denise] Natl Canc Inst Frederick, Frederick, MD USA.
[Kiepiela, Photini] MRC, HIV Prevent & Res Unit, Durban, South Africa.
[Mosam, Anisa; Mzolo, Similo] Univ KwaZulu Natal, Durban, South Africa.
RP Butler, LM (reprint author), Univ Calif San Francisco, 50 Beale St,Suite 120, San Francisco, CA 94105 USA.
EM lbutler@psg.ucsf.edu
OI Brander, Christian/0000-0002-0548-5778
FU CCR NIH HHS [HHSN261200800001C]; NCI NIH HHS [HHSN261200800001E, R01
CA119903]; NIAID NIH HHS [P30 AI027763, U01 AI052142]; NICHD NIH HHS
[K01 HD052020, K01 HD052020-03]; NIMH NIH HHS [T32 MH019105]
NR 51
TC 33
Z9 33
U1 0
U2 0
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD AUG 1
PY 2009
VL 200
IS 3
BP 430
EP 438
DI 10.1086/600103
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 465RH
UT WOS:000267604000015
PM 19534596
ER
PT J
AU Haynes, LM
Caidi, H
Radu, GU
Miao, C
Harcourt, JL
Tripp, RA
Anderson, LJ
AF Haynes, Lia M.
Caidi, Hayat
Radu, Gertrud U.
Miao, Congrong
Harcourt, Jennifer L.
Tripp, Ralph A.
Anderson, Larry J.
TI Therapeutic Monoclonal Antibody Treatment Targeting Respiratory
Syncytial Virus (RSV) G Protein Mediates Viral Clearance and Reduces the
Pathogenesis of RSV Infection in BALB/c Mice
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID SUBSTANCE-P; G-GLYCOPROTEIN; F-PROTEIN; CX3C MOTIF; BRONCHIOLITIS;
RESPONSES; EOSINOPHILIA; MACROPHAGES; EXPRESSION; INFANTS
AB Because the G protein of respiratory syncytial virus (RSV) has a CX3C chemokine motif that has been associated with the ability of RSV G protein to modulate the virus-induced host immune response, we examined whether therapeutic treatment with an anti-RSV G monoclonal antibody (mAb), 131-2G, that blocks the CX3C-associated activity of RSV G protein might decrease the pulmonary inflammation associated with infection in BALB/c mice. The results show that treatment with mAb 131-2G on day 3 after RSV infection reduces both inflammation and RSV titer in the lungs. Later administration of anti-RSV G mAb (day 5 after RSV infection) effectively reduced the viral titer but had a minimal effect on pulmonary inflammation. This study suggests that an anti-RSV G mAb might be an effective antiviral, either alone or in combination with anti-RSV F protein neutralizing antibodies, for decreasing the virus-induced host response to infection and improve treatment outcome.
C1 [Haynes, Lia M.; Caidi, Hayat; Radu, Gertrud U.; Miao, Congrong; Harcourt, Jennifer L.; Anderson, Larry J.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Gastroenteritis & Resp Viruses Lab Branch, Atlanta, GA USA.
[Tripp, Ralph A.] Univ Georgia, Dept Infect Dis, Coll Vet Med, Athens, GA 30602 USA.
RP Haynes, LM (reprint author), Natl Ctr Immunizat, Div Viral Dis, Resp & Gastroenteritis Viruses Branch, 1600 Clifton Rd NE,Mailstop G-18, Atlanta, GA 30333 USA.
EM loh5@cdc.gov
OI Tripp, Ralph/0000-0002-2924-9956
FU Oak Ridge Institute for Science and Education (ORISE); National
Institutes of Health [5R01AI06275-03]; Georgia Research Alliance
FX This research was supported in part by an appointment to the Research
Participation Program at the Centers for Disease Control and Prevention
(CDC), administered by the Oak Ridge Institute for Science and Education
(ORISE) through an interagency agreement between the Department of
Energy and the CDC. H.C. and G.U.R. are ORISE fellows. This research was
also supported in part by the National Institutes of Health (grant
5R01AI06275-03), by the Georgia Research Alliance (support R.A.T.), and
by a cooperative research and development agreement between Trellis
Biosciences and the CDC
NR 35
TC 44
Z9 46
U1 0
U2 1
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD AUG 1
PY 2009
VL 200
IS 3
BP 439
EP 447
DI 10.1086/600108
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 465RH
UT WOS:000267604000016
PM 19545210
ER
PT J
AU Promadej-Lanier, N
Smith, JM
Srinivasan, P
McCoy, CF
Butera, S
Woolfson, AD
Malcolm, RK
Otten, RA
AF Promadej-Lanier, Nattawan
Smith, James M.
Srinivasan, Priya
McCoy, Clare F.
Butera, Sal
Woolfson, A. David
Malcolm, R. Karl
Otten, Ron A.
TI Development and evaluation of a vaginal ring device for sustained
delivery of HIV microbicides to non-human primates
SO JOURNAL OF MEDICAL PRIMATOLOGY
LA English
DT Article
DE HIV interventions; macaques; mucosal transmission; SHIV
ID HUMAN-IMMUNODEFICIENCY-VIRUS; PRECLINICAL INTERVENTIONS; CONTRACEPTIVE
RING; INTRAVAGINAL RINGS; ESTRADIOL ACETATE; VACCINE RESEARCH;
CHALLENGES; PREVENTION; TRANSMISSION; INFECTION
AB Background
There is considerable interest in developing coitally independent, sustained release formulations for long-term administration of HIV microbicides. Vaginal ring devices are at the forefront of this formulation strategy.
Methods
Non-medicated silicone elastomer vaginal rings were prepared having a range of appropriate dimensions for testing vaginal fit in pig-tailed and Chinese rhesus macaques. Cervicovaginal proinflammatory markers were evaluated. Compression testing was performed to compare the relative flexibility of various macaque and commercial human rings.
Results
All rings remained in place during the study period and no tissue irritation or significant induction of cervicovaginal proinflammatory markers or signs of physical discomfort were observed during the 8-week study period.
Conclusions
Qualitative evaluation suggests that the 25 x 5-mm ring provided optimal fit in both macaque species. Based on the results presented here, low-consistency silicone elastomers do not cause irritation in macaques and are proposed as suitable materials for the manufacture of microbicide-loaded vaginal rings.
C1 [Promadej-Lanier, Nattawan; Smith, James M.; Srinivasan, Priya; Butera, Sal; Otten, Ron A.] Ctr Dis Control & Prevent, Branch Lab, Div HIV, AIDS Prevent,Natl Ctr HIV,STD,TB Prevent,CCID, Atlanta, GA USA.
[McCoy, Clare F.; Woolfson, A. David; Malcolm, R. Karl] Queens Univ Belfast, Ctr Med Biol, Sch Pharm, Belfast BT9 7BL, Antrim, North Ireland.
RP Otten, RA (reprint author), CDC, Branch Lab, DHAP, NCHSTP,CCID, Mailstop G-19,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM rxo1@cdc.gov
FU US Department of Health and Human Services
FX We thank Eddie Jackson, James Mitchell, and their colleagues in the
Animal Resources Branch (ARB), Division of Scientific Resources (DSR),
CDC (Atlanta, GA), for performing many macaque-related tasks including
the animal husbandry of the cohort associated with this study; Dr
Brianna Skinner-Harris of ARB, DSR, CDC for serving as the attending
veterinarian for this study. The findings and conclusions in this report
are those of the authors and do not necessarily represent the views of
CDC/ATSDR. The authors have no commercial or other associations that
might pose a conflict of interest. The use of trade names is for
identification only and does not constitute endorsement by the US
Department of Health and Human Services, the Public Health Service, or
the Centers for Disease Control and Prevention.
NR 45
TC 26
Z9 29
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0047-2565
J9 J MED PRIMATOL
JI J. Med. Primatol.
PD AUG
PY 2009
VL 38
IS 4
BP 263
EP 271
DI 10.1111/j.1600-0684.2009.00354.x
PG 9
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 466ZP
UT WOS:000267705000008
PM 19476564
ER
PT J
AU Zhang, Y
Zhou, JH
Bellini, WJ
Xu, WB
Rota, PA
AF Zhang, Yan
Zhou, Jianhui
Bellini, William J.
Xu, Wenbo
Rota, Paul A.
TI Genetic Characterization of Chinese Measles Vaccines by Analysis of
Complete Genomic Sequences
SO JOURNAL OF MEDICAL VIROLOGY
LA English
DT Article
DE measles; vaccine; genomic; sequence
ID VIRUS-VACCINE; MOLECULAR EPIDEMIOLOGY; ATTENUATION PHENOTYPES;
NUCLEOCAPSID PROTEIN; CELLULAR RECEPTOR; C-PROTEIN; REPLICATION;
STRAINS; TRANSCRIPTION; PARAMYXOVIRUSES
AB The complete genomic sequences of two Chinese measles vaccine viruses, Shanghai-191 (S-191) and Changchun-47 (C-47), were determined and compared to the sequences of other measles vaccine strains as well as the prototype measles strain, Edmonston wild-type (Edwt). Compared to Edwt, S-191 and C-47 had 49 and 43 nucleotide changes, respectively. These differences were found at 52 nucleotide positions that were not found in other vaccine strains. Phylogenetic analysis of the all of the available genomic sequences for measles vaccines showed that S-191 and C-47 were most closely related to the Leningrad-4 strain. S-191 and C-47 shared conserved vaccine virus-specific amino acid changes in the phosphoprotein (P), V, C, matrix (M), and hemagglutinin (H) that could represent important targets for future studies aimed at understanding the molecular basis of attenuation. In addition, S-191 and C-47 had several unique amino acid changes including 13 positions that differed from Edwt. This is the first comparison of the complete genomic sequences of Chinese measles vaccines to the sequences of other vaccine strains. J. Med. Virol. 81:1477-1483, 2009. (C) 2009 Wiley-Liss, Inc.
C1 [Zhang, Yan; Xu, Wenbo] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, State Key Lab Mol Virol & Genet Engn, Beijing 100050, Peoples R China.
[Zhang, Yan; Xu, Wenbo] World Hlth Org, Reg Measles Reference Lab Western Pacific Reg, Beijing, Peoples R China.
[Zhang, Yan; Bellini, William J.; Rota, Paul A.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA.
[Zhou, Jianhui] Jilin Prov Ctr Dis Control & Prevent, Changchun, Peoples R China.
RP Xu, WB (reprint author), Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, State Key Lab Mol Virol & Genet Engn, 27 Nanwei Rd, Beijing 100050, Peoples R China.
EM wenbo_xu1@yahoo.com.cn
NR 41
TC 7
Z9 10
U1 0
U2 3
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0146-6615
J9 J MED VIROL
JI J. Med. Virol.
PD AUG
PY 2009
VL 81
IS 8
BP 1477
EP 1483
DI 10.1002/jmv.21535
PG 7
WC Virology
SC Virology
GA 465TR
UT WOS:000267611000021
PM 19551837
ER
PT J
AU Ku, BK
Kulkarni, P
AF Ku, Bon Ki
Kulkarni, Pramod
TI Morphology of single-wall carbon nanotube aggregates generated by
electrospray of aqueous suspensions
SO JOURNAL OF NANOPARTICLE RESEARCH
LA English
DT Article
DE Single-wall carbon nanotubes (SWCNTs); Electrosprays; Water suspensions;
Straight fiber; Aerosols; Agglomeration
ID PULMONARY TOXICITY; MOBILITY ANALYSIS; SCALING LAWS; HEALTH-RISKS; SIZE;
NANOPARTICLES; RESPONSES; EXPOSURE; MICE
AB Airborne single-wall carbon nanotubes (SWCNTs) have a high tendency to agglomerate due to strong interparticle attractive forces. The SWCNT agglomerates generally have complex morphologies with an intricate network of bundles of nanotubes and nanoropes, which limits their usefulness in many applications. It is thus desirable to produce SWCNT aerosol particles that have well-defined, unagglomerated fibrous morphologies. We present a method to generate unagglomerated, fibrous particles of SWCNT aerosols using capillary electrospray of aqueous suspensions. The effects of the operating parameters of capillary electrospray such as strength of buffer solution, capillary diameter, flow rate, and colloidal particle concentration on the size distributions of SWCNT aerosols were investigated. Results showed that electrospray from a suspension of higher nanotube concentration produced a bimodal distribution of SWCNT aerosols. Monodisperse SWCNT aerosols below 100 nm were mostly non-agglomerated single fibers, while polydisperse aerosols larger than 100 nm had two distinct morphologies: a ribbon shape and the long, straight fiber. Possible mechanisms are suggested to explain the formation of the different shapes, which could be used to produce SWCNT aerosols with different morphologies.
C1 [Ku, Bon Ki; Kulkarni, Pramod] Ctr Dis Control & Prevent, CDC, NIOSH, Cincinnati, OH 45226 USA.
RP Ku, BK (reprint author), Ctr Dis Control & Prevent, CDC, NIOSH, 4676 Columbia Pkwy,MS R3, Cincinnati, OH 45226 USA.
EM BKu@cdc.gov; PSKulkarni@cdc.gov
FU National Institute for Occupational Safety and Health [CAN 9270082]
FX This work was funded by the National Institute for Occupational Safety
and Health through the National Occupational Research Agenda (NORA)
program ( Project CAN 9270082).
NR 32
TC 13
Z9 13
U1 1
U2 14
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1388-0764
J9 J NANOPART RES
JI J. Nanopart. Res.
PD AUG
PY 2009
VL 11
IS 6
BP 1393
EP 1403
DI 10.1007/s11051-008-9527-4
PG 11
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 482BH
UT WOS:000268857900010
ER
PT J
AU Laney, AS
Attfield, MD
AF Laney, A. Scott
Attfield, Michael D.
TI Quartz Exposure Can Cause Pneumoconiosis in Coal Workers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Letter
ID MINE DUST
C1 [Laney, A. Scott; Attfield, Michael D.] NIOSH, Div Resp Dis Studies, Surveillance Branch, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
RP Laney, AS (reprint author), NIOSH, Div Resp Dis Studies, Surveillance Branch, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
NR 10
TC 5
Z9 5
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD AUG
PY 2009
VL 51
IS 8
BP 867
EP 867
DI 10.1097/JOM.0b013e3181b2f3f1
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 482OU
UT WOS:000268899400001
PM 19667833
ER
PT J
AU Wei, MC
Banaei, N
Yakrus, MA
Stoll, T
Gutierrez, KM
Agarwal, R
AF Wei, Michael C.
Banaei, Niaz
Yakrus, Mitchell A.
Stoll, Tracey
Gutierrez, Kathleen M.
Agarwal, Rajni
TI Nontuberculous Mycobacteria Infections in Immunocompromised Patients
Single Institution Experience
SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
LA English
DT Article
DE pediatrics; Mycobacterium; oncology; transplant; bacteremia; pulmonary
ID RAPIDLY GROWING MYCOBACTERIA; CATHETER-RELATED INFECTIONS; CHELONAE;
CHILDREN; CLARITHROMYCIN; BACTEREMIA; DISEASES
AB Disseminated infection due to nontuberculous Mycobacterium (NTM) species is rare in pediatrics. Here we report 6 infections affecting 5 patients at a single institution in ail immunocompromised population of pediatric oncology and stem cell transplant recipients. The patients presented within a I-year period with catheter-associated bacteremia. New pulmonary nodules were noted in 4 of the 5 patients. All of the infections were due to rapidly growing NTM. Patients were successfully treated with removal of the infected catheter and combination antibiotic therapy. There are currently no consensus guidelines for treatment of NTM infections in this population, and a therapeutic approach is presented here.
C1 [Wei, Michael C.; Gutierrez, Kathleen M.; Agarwal, Rajni] Stanford Univ, Sch Med, Dept Pediat, Palo Alto, CA 94604 USA.
[Wei, Michael C.] Stanford Univ, Sch Med, Div Pediat Hematol Oncol, Palo Alto, CA 94604 USA.
[Gutierrez, Kathleen M.] Stanford Univ, Sch Med, Div Infect Dis, Palo Alto, CA 94604 USA.
[Agarwal, Rajni] Stanford Univ, Sch Med, Div Pediat Stem Cell Transplantat, Palo Alto, CA 94604 USA.
[Banaei, Niaz] Stanford Univ, Sch Med, Dept Pathol, Palo Alto, CA 94604 USA.
[Wei, Michael C.; Stoll, Tracey; Gutierrez, Kathleen M.; Agarwal, Rajni] Lucile Packard Childrens Hosp, Palo Alto, CA USA.
[Yakrus, Mitchell A.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Agarwal, R (reprint author), Stanford Univ, Sch Med, Dept Pediat, 1000 Welch Rd,Suite 301, Palo Alto, CA 94604 USA.
EM kdnakash@stanford.edu
NR 18
TC 8
Z9 9
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1077-4114
J9 J PEDIAT HEMATOL ONC
JI J. Pediatr. Hematol. Oncol.
PD AUG
PY 2009
VL 31
IS 8
BP 556
EP 560
PG 5
WC Oncology; Hematology; Pediatrics
SC Oncology; Hematology; Pediatrics
GA 481MH
UT WOS:000268815000006
PM 19641470
ER
PT J
AU Paris, CA
Imperatore, G
Klingensmith, G
Petitti, D
Rodriguez, B
Anderson, AM
Schwartz, ID
Standiford, DA
Pihoker, C
AF Paris, Carolyn A.
Imperatore, Giuseppina
Klingensmith, Georgeanna
Petitti, Diana
Rodriguez, Beatriz
Anderson, Andrea M.
Schwartz, I. David
Standiford, Debra A.
Pihoker, Catherine
TI Predictors of Insulin Regimens and Impact on Outcomes in Youth with Type
1 Diabetes: The SEARCH for Diabetes in Youth Study
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID HVIDORE STUDY-GROUP; METABOLIC-CONTROL; PUMP THERAPY; CHILDREN;
ADOLESCENTS; MELLITUS; INFUSION; CARE; COMPLICATIONS; CHILDHOOD
AB Objectives To describe the insulin regimens used to treat type 1 diabetes mellitus (T1DM) in youth in the United States, to explore factors related to insulin regimen, and to describe the associations between insulin regimen and clinical outcomes, particularly glycemic control.
Study design A total of 2743 subjects participated in the SEARCH for Diabetes in Youth study, an observational population-based study of youth diagnosed with T1DM, conducted at 6 centers. Data collected during a study visit included clinical and sociodemographic information, body mass index, laboratory measures, and insulin regimen.
Results Sociodemographic characteristics were associated with insulin regimen. Insulin pump therapy was more frequently used by older youth, females, non-Hispanic whites, and families with higher income and education (P = .02 for females, P < .001 for others). Insulin pump use was associated with the lowest hemoglobin A1C levels in all age groups. A1C levels were >7.5% in >70% of adolescents, regardless of regimen.
Conclusions Youth using insulin pumps had the lowest A1C; A1C was unacceptably high in adolescents. There is a need to more fully assess and understand factors associated with insulin regimens recommended by providers and the influence of race/ethnicity, education, and socioeconomic status on these treatment recommendations and to develop more effective treatment strategies, particularly for adolescents. (J Pediatr 2009; 155:183-9).
C1 [Paris, Carolyn A.; Pihoker, Catherine] Univ Washington, Seattle, WA 98195 USA.
[Imperatore, Giuseppina] Ctr Dis Control & Prevent, Div Diabet Translat, NCCDPHP, Atlanta, GA USA.
[Klingensmith, Georgeanna] Univ Colorado, Barbara Davis Ctr Childhood Diabet, Denver, CO 80202 USA.
[Klingensmith, Georgeanna] Univ Colorado, Hlth Sci Ctr, Denver, CO USA.
[Petitti, Diana] Kaiser Permanente So Calif, Pasadena, CA USA.
[Rodriguez, Beatriz] Pacific Hlth Res Inst, Honolulu, HI USA.
[Anderson, Andrea M.] Wake Forest Univ, Winston Salem, NC 27109 USA.
[Schwartz, I. David] Univ S Carolina, Columbia, SC 29208 USA.
[Standiford, Debra A.] Childrens Hosp Med Ctr, Cincinnati, OH USA.
RP Paris, CA (reprint author), Childrens Hosp & Reg Med Ctr, 4800 Sand Point Way NE,B-5518, Seattle, WA 98105 USA.
EM Carolyn.paris@seattlechildrens.org
FU NCCDPHP CDC HHS [U01 DP000245, U01 DP000244, U01 DP000246, U01 DP000247,
U01 DP000248, U01 DP000250, U01 DP000254]; NCRR NIH HHS [M01 RR00069,
M01 RR01070, M01 RR08084, M01RR00037, M01RR001271]
NR 19
TC 66
Z9 69
U1 0
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD AUG
PY 2009
VL 155
IS 2
BP 183
EP 189
DI 10.1016/j.jpeds.2009.01.063
PG 7
WC Pediatrics
SC Pediatrics
GA 481BJ
UT WOS:000268781200010
PM 19394043
ER
PT J
AU Johnson, JL
Eaton, DK
Pederson, LL
Lowry, R
AF Johnson, Jonetta L.
Eaton, Danice K.
Pederson, Linda L.
Lowry, Richard
TI Associations of Trying to Lose Weight, Weight Control Behaviors, and
Current Cigarette Use Among US High School Students
SO JOURNAL OF SCHOOL HEALTH
LA English
DT Article
DE nutrition and diet; smoking and tobacco; risk behaviors
ID BODY-WEIGHT; ADOLESCENT SMOKING; GENDER
AB BACKGROUND
Approximately one-quarter of high school students currently use cigarettes. Previous research has suggested some youth use smoking as a method for losing weight. The purpose of this study was to describe the association of current cigarette use with specific healthy and unhealthy weight control practices among 9th-12th grade students in the United States.
METHODS
Youth Risk Behavior Survey data (2005) were analyzed. Behaviors included current cigarette use, trying to lose weight, and current use of 2 healthy and 3 unhealthy behaviors to lose weight or to keep from gaining weight. Separate logistic regression models calculated adjusted odds ratios (AORs) for associations of current cigarette use with trying to lose weight (Model 1) and the 5 weight control behaviors, controlling for trying to lose weight (Model 2).
RESULTS
In Model 1, compared with students who were not trying to lose weight, students who were trying to lose weight had higher odds of current cigarette use (AOR = 1.30, 95% CI: 1.15-1.49). In Model 2, the association of current cigarette use with the 2 healthy weight control behaviors was not statistically significant. Each of the 3 unhealthy weight control practices was significantly associated with current cigarette use, with AORs for each behavior approximately 2 times as high among those who engaged in the behavior, compared with those who did not.
CONCLUSION
Some students may smoke cigarettes as a method of weight control. Inclusion of smoking prevention messages into existing weight management interventions may be beneficial.
C1 [Johnson, Jonetta L.] Univ Michigan, Sch Publ Hlth, Dept Hlth Behav & Hlth Educ, Ann Arbor, MI 48109 USA.
[Eaton, Danice K.] CDC, US PHS, SERB DASH NCCDPHP, Atlanta, GA 30341 USA.
[Pederson, Linda L.] Ctr Dis Control & Prevent, Hlth Commun Branch Senior Serv, Off Smoking & Hlth, Atlanta, GA 30341 USA.
RP Johnson, JL (reprint author), Univ Michigan, Sch Publ Hlth, Dept Hlth Behav & Hlth Educ, 109 S Observ St, Ann Arbor, MI 48109 USA.
EM jonettaj@umich.edu; DEaton@cdc.gov; lindap@mindspring.com; rxl1@cdc.gov
NR 22
TC 10
Z9 10
U1 1
U2 8
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0022-4391
J9 J SCHOOL HEALTH
JI J. Sch. Health
PD AUG
PY 2009
VL 79
IS 8
BP 355
EP 360
PG 6
WC Education & Educational Research; Education, Scientific Disciplines;
Health Care Sciences & Services; Public, Environmental & Occupational
Health
SC Education & Educational Research; Health Care Sciences & Services;
Public, Environmental & Occupational Health
GA 471LF
UT WOS:000268058500003
PM 19630869
ER
PT J
AU Buss, BF
Mueller, SW
Theis, M
Keyser, A
Safranek, TJ
AF Buss, Bryan F.
Mueller, Shawn W.
Theis, Max
Keyser, Alison
Safranek, Thomas J.
TI Population-Based Estimates of Methicillin-Resistant Staphylococcus
aureus (MRSA) Infections Among High School Athletes-Nebraska, 2006-2008
SO JOURNAL OF SCHOOL NURSING
LA English
DT Article
DE athlete health; communicable diseases; high school; quantitative
research
ID FOOTBALL TEAM; COMMUNITY; OUTBREAK; PLAYERS; SKIN
AB Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging cause of skin and soft-tissue infections among athletes. To determine statewide incidence among high school athletes, we surveyed all 312 Nebraska high schools regarding sport programs offered, program-specific participation numbers, number of athletes with physician-diagnosed MRSA infections, and athlete's sport at infection onset. Among 271 (86.9%) schools responding, MRSA infections were reported among one or more athletes by 4.4% (12/270) and 14.4% (39/271) during school years 2006-2007 and 2007-2008, respectively. From 2006-2007 to 2007-2008, MRSA incidence per 10,000 wrestlers increased from 19.6 to 60.1, and incidence per 10,000 football players increased from 5.0 to 25.1. We did not identify differences in distribution of MRSA infections on the basis of grade, school enrollment, location, or number of participants per team. Incidence of reported MRSA infections among football players and wrestlers was substantially higher during 2007- 2008, compared with 2006-2007.
C1 [Buss, Bryan F.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Buss, Bryan F.; Theis, Max; Keyser, Alison; Safranek, Thomas J.] Nebraska Dept Hlth & Human Serv, Lincoln, NE USA.
[Mueller, Shawn W.] BryanLGH Med Ctr, Lincoln, NE USA.
RP Buss, BF (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
NR 16
TC 10
Z9 10
U1 1
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1059-8405
J9 J SCH NURS
JI J. Sch. Nurs.
PD AUG
PY 2009
VL 25
IS 4
BP 282
EP 291
DI 10.1177/1059840509333454
PG 10
WC Nursing
SC Nursing
GA 483TH
UT WOS:000268990600006
PM 19351966
ER
PT J
AU Zhu, XD
Kim, JH
Song, WJ
Murphy, WJ
Song, S
AF Zhu, Xiangdong
Kim, Jay H.
Song, Won Joon
Murphy, William J.
Song, Seongho
TI Development of a noise metric for assessment of exposure risk to complex
noises
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID ANALYTIC WAVELET TRANSFORM; INDUCED HEARING-LOSS; NON-GAUSSIAN NOISE;
IMPULSE-NOISE; THRESHOLD SHIFTS; INDUCED TRAUMA; IMPACT NOISE; CELL
LOSS; ENERGY; CHINCHILLA
AB Many noise guidelines currently use A-weighted equivalent sound pressure level L(Aeq) as the noise metric and the equal energy hypothesis to assess the risk of occupational noises. Because of the time-averaging effect involved with the procedure, the current guidelines may significantly underestimate the risk associated with complex noises. This study develops and evaluates several new noise metrics for more accurate assessment of exposure risks to complex and impulsive noises. The analytic wavelet transform was used to obtain time-frequency characteristics of the noise. 6 basic, unique metric forms that reflect the time-frequency characteristics were developed, from which 14 noise metrics were derived. The noise metrics were evaluated utilizing existing animal test data that were obtained by exposing 23 groups of chinchillas to, respectively, different types of noise. Correlations of the metrics with the hearing losses observed in chinchillas were compared and the most promising noise metric was identified. (C) 2009 Acoustical Society of America. [DOI: 10.1121/1.3159587]
C1 [Zhu, Xiangdong; Kim, Jay H.; Song, Won Joon] Univ Cincinnati, Dept Mech Engn, Cincinnati, OH 45221 USA.
[Murphy, William J.] NIOSH, Div Appl Res & Technol, Engn & Phys Hazards Branch, Hearing Loss Prevent Team, Cincinnati, OH 45226 USA.
[Song, Seongho] Univ Cincinnati, Dept Math Sci, Cincinnati, OH 45221 USA.
RP Kim, JH (reprint author), Univ Cincinnati, Dept Mech Engn, Cincinnati, OH 45221 USA.
EM jay.kim@uc.edu
OI Song, Won Joon/0000-0001-8644-6051
FU National Institute for Occupational Safety and Health [R21 OH008510]
FX This project was supported by the National Institute for Occupational
Safety and Health, Grant No. R21 OH008510. The authors thank Roger
Hamernik and Wei Qiu at the State University of New York at Plattsburgh
for providing chinchilla noise exposure study data and advice in
interpreting the data.
NR 39
TC 8
Z9 9
U1 0
U2 3
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD AUG
PY 2009
VL 126
IS 2
BP 703
EP 712
DI 10.1121/1.3159587
PG 10
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA 483XO
UT WOS:000269006800022
PM 19640036
ER
PT J
AU Griffin, SO
Gooch, BF
Gray, SK
Malvitz, DM
AF Griffin, Susan O.
Gooch, Barbara F.
Gray, Shellie Kolavic
Malvitz, Dolores M.
TI SEALANTS REVISITED Response
SO JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
LA English
DT Letter
C1 [Gooch, Barbara F.] Ctr Dis Control & Prevent, Surveillance Invest & Res Team, Div Oral Hlth, Chamblee, GA USA.
[Gray, Shellie Kolavic] Northrop Grumman, Publ Hlth Div, Atlanta, GA USA.
[Malvitz, Dolores M.] Palladian Partners, Silver Spring, MD USA.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU AMER DENTAL ASSOC
PI CHICAGO
PA 211 E CHICAGO AVE, CHICAGO, IL 60611 USA
SN 0002-8177
J9 J AM DENT ASSOC
JI J. Am. Dent. Assoc.
PD AUG
PY 2009
VL 140
IS 8
BP 970
EP 971
PG 2
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 482CP
UT WOS:000268861800009
ER
PT J
AU Stevens, JA
Thomas, K
Teh, L
Greenspan, AI
AF Stevens, Judy A.
Thomas, Karen
Teh, Leesia
Greenspan, Arlene I.
TI Unintentional Fall Injuries Associated with Walkers and Canes in Older
Adults Treated in US Emergency Departments
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE cane; elderly; fall; injury; unintentional injury; walker
ID ASSISTIVE DEVICES; FUNCTIONAL STATUS; HIP FRACTURE; PREVENTION; PEOPLE;
TRIAL; HOME
AB OBJECTIVES
To characterize nonfatal, unintentional, fall-related injuries associated with walkers and canes in older adults.
DESIGN
Surveillance data of injuries treated in hospital emergency departments (EDs), January 1, 2001, to December 31, 2006.
SETTING
The National Electronic Injury Surveillance System All Injury Program, which collects data from a nationally representative stratified probability sample of 66 U.S. hospital EDs.
PARTICIPANTS
People aged 65 and older treated in EDs for 3,932 nonfatal unintentional fall injuries and whose records indicated that a cane or a walker was involved in the fall.
MEASUREMENTS
Sex, age, whether the fall involved a cane or walker, primary diagnosis, part of the body injured, disposition, and location and circumstances of the fall.
RESULTS
An estimated 47,312 older adult fall injuries associated with walking aids were treated annually in U.S. EDs: 87.3% with walkers, 12.3% with canes, and 0.4% with both. Walkers were associated with seven times as many injuries as canes. Women's injury rates exceeded those for men (rate ratios=2.6 for walkers, 1.4 for canes.) The most prevalent injuries were fractures and contusions or abrasions. Approximately one-third of subjects were hospitalized for their injuries.
CONCLUSION
Injuries and hospital admissions for falls associated with walking aids were frequent in this highly vulnerable population. The results suggest that more research is needed to improve the design of walking aids. More information also is needed about the circumstances preceding falls, both to better understand the contributing fall risk factors and to develop specific and effective fall prevention strategies.
C1 [Stevens, Judy A.; Thomas, Karen; Teh, Leesia; Greenspan, Arlene I.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA.
RP Stevens, JA (reprint author), 4770 Buford Highway NE,Mailstop F-62, Atlanta, GA 30341 USA.
EM jas2@cdc.gov
FU The Centers for Disease Control and Prevention
FX Sponsor's Role: The Centers for Disease Control and Prevention supports
the surveillance system that collected the data used in this analysis.
NR 27
TC 34
Z9 34
U1 1
U2 16
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0002-8614
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD AUG
PY 2009
VL 57
IS 8
BP 1464
EP 1469
DI 10.1111/j.1532-5415.2009.02365.x
PG 6
WC Geriatrics & Gerontology; Gerontology
SC Geriatrics & Gerontology
GA 477QH
UT WOS:000268533100018
PM 19555423
ER
PT J
AU Hettick, JM
Ruwona, TB
Siegel, PD
AF Hettick, Justin M.
Ruwona, Tinashe B.
Siegel, Paul D.
TI Structural Elucidation of Isocyanate-Peptide Adducts Using Tandem Mass
Spectrometry
SO JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
LA English
DT Article
ID TOLUENE DIISOCYANATE; 4,4'-METHYLENEDIPHENYL DIISOCYANATE; DISSOCIATION;
PROTEINS; WORKERS; AMINO; IONS; IDENTIFICATION; PROTEOMICS; ALBUMIN
AB Diisocyanates are highly reactive chemical compounds widely used in the manufacture of polyurethanes. Although diisocyanates have been identified as causative agents of allergic respiratory diseases, the specific mechanism by which these diseases Occur is largely unknown. To better understand the chemical species produced when isocyanates are reacted with model peptides, tandem mass spectrometry was employed to unambiguously identify the binding site of four commercially-relevant isocyanates on model peptides. In each case, the isocyanates react preferentially with the N-terminus of the peptide. No evidence of side-chain/isocyanate adduct formation exclusive of the N-terminus was observed. However, significant intra-molecular diisocyanate crosslinking was observed between the N-terminal amine and a side-chain amine of arginine, when Arg was located within two residues of the N-terminus. Addition of multiple isocyanates to the peptide Occurs via polymerization of the isocyanate at the N-terminus, rather than via addition of multiple isocyanate molecules to varied residues within the peptide. The direct observation of isocyanate binding to the N-terminus of peptides under these experimental conditions is in good agreement with previous studies oil the relative reaction rate of isocyanate with amino acid functional groups. (J Am Soc Mass Spectrom 2009, 20,1567-1575) (C) 2009 Published by Elsevier Inc. on behalf of American Society for Mass Spectrometry
C1 [Hettick, Justin M.; Ruwona, Tinashe B.; Siegel, Paul D.] NIOSH, Ctr Dis Control & Prevent, Hlth Effects Lab Div, Morgantown, WV 26505 USA.
RP Hettick, JM (reprint author), NIOSH, Ctr Dis Control & Prevent, Hlth Effects Lab Div, MS L-2040,1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM jhettick@cdc.gov
RI Hettick, Justin/E-9955-2010
NR 30
TC 12
Z9 12
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1044-0305
J9 J AM SOC MASS SPECTR
JI J. Am. Soc. Mass Spectrom.
PD AUG
PY 2009
VL 20
IS 8
BP 1567
EP 1575
DI 10.1016/j.jasms.2009.04.016
PG 9
WC Chemistry, Analytical; Chemistry, Physical; Spectroscopy
SC Chemistry; Spectroscopy
GA 480MV
UT WOS:000268739900022
PM 19477659
ER
PT J
AU Teten, AL
Schumacher, JA
Bailey, SD
Kent, TA
AF Teten, Andra L.
Schumacher, Julie A.
Bailey, Sara D.
Kent, Thomas A.
TI Male-to-Female Sexual Aggression Among Iraq, Afghanistan, and Vietnam
Veterans: Co-Occurring Substance Abuse and Intimate Partner Aggression
SO JOURNAL OF TRAUMATIC STRESS
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; COMBAT VETERANS; MILITARY VETERANS;
VIOLENCE; BEHAVIOR; ASSAULT; VICTIMIZATION; PREVALENCE; SYMPTOMS;
DEFICITS
AB The current study examined the frequency and correlates of coercive sexual behaviors by male Iraq, Afghanistan, and/or Vietnam veterans recruited from a Veterans Affairs trauma recovery clinic (n = 92) toward their female partners. Men who reported sexual aggression in the past year (n = 37) compared to men who did not report sexual aggression in the past year (n = 55) more frequently reported impulsive aggression, dominating/isolating, and physically assaulting their partner, and were more likely to have a substance abuse diagnosis. Sexually aggressive men were significantly less likely than nonsexually aggressive men to have a diagnosis of depression. Posttraumatic stress disorder, an established risk factor for nonsexual partner aggression among veterans, was not associated with sexual aggression.
C1 [Teten, Andra L.; Bailey, Sara D.; Kent, Thomas A.] Baylor Coll Med, Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA.
[Teten, Andra L.; Bailey, Sara D.] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
[Schumacher, Julie A.] Univ Mississippi, Med Ctr, Dept Psychiat, Jackson, MS 39216 USA.
[Kent, Thomas A.] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA.
RP Teten, AL (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Hwy,MS F-64, Atlanta, GA 30341 USA.
EM ateten@cdc.gov
OI Kent, Thomas/0000-0002-9877-7584
NR 24
TC 12
Z9 12
U1 0
U2 5
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0894-9867
J9 J TRAUMA STRESS
JI J. Trauma Stress
PD AUG
PY 2009
VL 22
IS 4
BP 307
EP 311
DI 10.1002/jts.20422
PG 5
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA 489AH
UT WOS:000269391300008
PM 19588515
ER
PT J
AU Akinsanya-Beysolow, I
Wolfe, C
AF Akinsanya-Beysolow, Iyabode
Wolfe, Charles (Skip)
TI Update: Vaccines for Women, Adolescence through Adulthood
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID OBSTETRICIAN-GYNECOLOGISTS; CARE; REIMBURSEMENT; IMMUNIZATION; CANCER;
SYSTEM
AB Recommendations for routine vaccination of adolescents and adults are continually evolving; new vaccines are licensed, and ongoing studies lead to updated recommendations for existing vaccines. Although vaccination is important for both sexes, some recent developments are particularly relevant for women and girls. Human papillomavirus (HPV) vaccine, licensed in 2006, is the first vaccine administered exclusively to women. Another recently licensed vaccine, adult and adolescent tetanus-diphtheria-acellular pertussis (Tdap), is especially important for women who plan to become pregnant and for new mothers to help prevent pertussis disease in infants who are too young to be vaccinated themselves. Other vaccines, such as influenza and rubella, are also important for pregnant women. Several vaccine safety issues are of particular relevance to women, namely, the theoretical risk of administering live vaccines during pregnancy and data suggesting that adolescent females might be at higher risk for syncope following vaccination. Obstetrician-gynecologists are the primary, and sometimes only, contact with the healthcare system for many adolescent and adult women and, as such, are uniquely positioned to provide vaccination services to the country's female population. Vaccine costs, storage and handling requirements, lack of access to immunization information systems ( also known as vaccine registries), and unfamiliarity with current recommendations are potential obstacles to ensuring that all adolescent females and women are appropriately vaccinated. Obstetrician-gynecologists can help reduce some of these obstacles by availing themselves of existing vaccination resources.
C1 [Akinsanya-Beysolow, Iyabode; Wolfe, Charles (Skip)] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Wolfe, C (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,NE,Mailstop E-52, Atlanta, GA 30333 USA.
EM crw4@cdc.gov
NR 30
TC 3
Z9 3
U1 1
U2 3
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD AUG
PY 2009
VL 18
IS 8
BP 1101
EP 1108
DI 10.1089/jwh.2009.1525
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Obstetrics & Gynecology; Women's Studies
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Obstetrics & Gynecology; Women's Studies
GA 482CC
UT WOS:000268860300001
PM 19627241
ER
PT J
AU Ross, DS
Rasmussen, SA
Cannon, MJ
Anderson, B
Kilker, K
Tumpey, A
Schulkin, J
Jones, JL
AF Ross, Danielle S.
Rasmussen, Sonja A.
Cannon, Michael J.
Anderson, Britta
Kilker, Katie
Tumpey, Abbigail
Schulkin, Jay
Jones, Jeffrey L.
TI Obstetrician/Gynecologists' Knowledge, Attitudes, and Practices
regarding Prevention of Infections in Pregnancy
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID TO-MOTHER TRANSMISSION; CONGENITAL TOXOPLASMOSIS; UNITED-STATES;
PRIMARY-CARE; CYTOMEGALOVIRUS; PHYSICIANS; BEHAVIORS; IMPACT; WOMEN;
GYNECOLOGISTS
AB Background: Maternal infection during pregnancy is a well-recognized cause of birth defects and developmental disabilities, as well as an important contributor to other adverse pregnancy outcomes. The objective of the present survey was to gain information about the knowledge, attitudes, and practices of obstetrician/gynecologists regarding prevention of infections during pregnancy.
Methods: A survey was mailed to 606 Collaborative Ambulatory Research Network ( CARN) members of the American College of Obstetricians and Gynecologists (ACOG) ( approximately 2% of membership). CARN members were sampled to demographically represent ACOG.
Results: Of the 606 eligible respondents, surveys were received from 305 (response rate: 50%). Most obstetrician/gynecologists knew that specific actions by pregnant women could reduce the risk of infection. Seventy-nine to eighty-eight percent reported counseling pregnant women about preventing infection from Toxoplasma gondii, hepatitis B virus, and influenza, 50%-68% about varicella-zoster virus, Listeria monocytogenes, and Parvovirus B19, and <50% about cytomegalovirus, Bordetella pertussis, and lymphocytic choriomeningitis virus. The majority reported time constraints were a barrier to counseling, although most reported educational materials would be helpful.
Conclusions: Knowledge was accurate and preventive counseling was appropriate for some infections, but for others it could be improved. Further studies are needed to identify strategies to increase preventive counseling.
C1 [Ross, Danielle S.; Rasmussen, Sonja A.; Cannon, Michael J.; Kilker, Katie; Tumpey, Abbigail; Jones, Jeffrey L.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Anderson, Britta; Schulkin, Jay] Amer Coll Obstetricians & Gynecologists, Washington, DC 20024 USA.
RP Ross, DS (reprint author), 1600 Clifton Rd NE,MS E-88, Atlanta, GA 30333 USA.
EM dross3@cdc.gov
RI Cannon, Michael/E-5894-2011
OI Cannon, Michael/0000-0001-5776-5010
FU Maternal and Child Health Bureau [R60 MC 05674]; Health Resources and
Services Administration; Department of Health and Human Services
FX This survey was supported by grant R60 MC 05674 from Maternal and Child
Health Bureau ( Title V, Social Security Act), Health Resources and
Services Administration, Department of Health and Human Services.
NR 36
TC 26
Z9 26
U1 1
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD AUG
PY 2009
VL 18
IS 8
BP 1187
EP 1193
DI 10.1089/jwh.2008.1288
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Obstetrics & Gynecology; Women's Studies
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Obstetrics & Gynecology; Women's Studies
GA 482CC
UT WOS:000268860300013
PM 19670963
ER
PT J
AU Blake, TA
Williams, TL
Pirkle, JL
Barr, JR
AF Blake, T. A.
Williams, T. L.
Pirkle, J. L.
Barr, J. R.
TI Analysis of H5N1 Influenza Hemagglutinin Glycosylation by LC/MS/MS
Utilizing Hydrazide Capture SPE and HILIC Separation of Intact
Glycopeptides
SO MOLECULAR & CELLULAR PROTEOMICS
LA English
DT Meeting Abstract
C1 Ctr Dis Control, Atlanta, GA 30333 USA.
Ctr Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 2
U2 4
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 1535-9476
J9 MOL CELL PROTEOMICS
JI Mol. Cell. Proteomics
PD AUG
PY 2009
BP S50
EP S50
PG 1
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA 483CH
UT WOS:000268939000080
ER
PT J
AU Murashov, V
Howard, J
AF Murashov, Vladimir
Howard, John
TI Essential features for proactive risk management
SO NATURE NANOTECHNOLOGY
LA English
DT Article
ID CONTROL BANDING TOOL; NANOTECHNOLOGY; SCIENCE
C1 [Murashov, Vladimir] NIOSH, Washington, DC 20201 USA.
[Howard, John] Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, Washington, DC 20201 USA.
RP Murashov, V (reprint author), NIOSH, 395 E St SW,Suite 9200, Washington, DC 20201 USA.
EM vladimir.murashov@cdc.hhs.gov
RI Murashov, Vladimir/K-5481-2012
NR 43
TC 27
Z9 27
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1748-3387
EI 1748-3395
J9 NAT NANOTECHNOL
JI Nat. Nanotechnol.
PD AUG
PY 2009
VL 4
IS 8
BP 467
EP 470
DI 10.1038/nnano.2009.205
PG 4
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA 483DO
UT WOS:000268942400002
PM 19661998
ER
PT J
AU Akinbami, LJ
Ogden, CL
AF Akinbami, Lara J.
Ogden, Cynthia L.
TI Childhood Overweight Prevalence in the United States: The Impact of
Parent-reported Height and Weight
SO OBESITY
LA English
DT Article
ID BODY-MASS INDEX; SCHOOL-STUDENTS; SELF-REPORTS; US CHILDREN;
ADOLESCENTS; OBESITY; ACCURACY; VALIDITY; BMI; RELIABILITY
AB Parent-reported height and weight are often used to estimate BMI and overweight status among children. The quality of parent-reported data has not been compared to measured data on a national scale for all race/ethnic groups in the United States. Parent-reported height and weight for 2-17-year-old children in two national health interview surveys-the 1999-2004 National Health Interview Survey (NHIS) and the 2003-2004 National Survey of Children's Health (NSCH)-were compared to measured values from a national examination survey-the 1999-2004 National Health and Nutrition Examination Survey (NHANES). Compared to measured data, parent-reported data overestimated childhood overweight in both interview surveys. For example, overweight prevalence among 2-17-year-olds was 25% (s.e. 0.2) using parent-reported NHIS data vs. 16% (s.e. 0.6) using measured NHANES data. Parent-reported data overestimated overweight among younger children, but underestimated overweight among older children. The discrepancy between reported and measured estimates arose mainly from reported height among very young children. For children aged 2-11 years, the mean reported height from NHIS was 3-6 cm less than mean measured height from NHANES (P < 0.001) vs. no difference among children aged 16-17 years. Measured data remains the gold standard for surveillance of childhood overweight. Although this analysis compared mean values from survey populations rather than parent-reported and measured data for individuals, the results from nationally representative data reinforce previous recommendations based on small samples that parent-reported data should not be used to estimate overweight prevalence among preschool and elementary school-aged children.
C1 [Akinbami, Lara J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Child & Womens Hlth Stat Branch, Hyattsville, MD 20782 USA.
[Akinbami, Lara J.] US PHS, Rockville, MD USA.
[Ogden, Cynthia L.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Hlth & Nutr Examinat Surveys, Hyattsville, MD 20782 USA.
RP Akinbami, LJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Child & Womens Hlth Stat Branch, Hyattsville, MD 20782 USA.
EM lakinbami@cdc.gov
NR 33
TC 75
Z9 75
U1 1
U2 7
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD AUG
PY 2009
VL 17
IS 8
BP 1574
EP 1580
DI 10.1038/oby.2009.1
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 475QD
UT WOS:000268374200016
PM 19629061
ER
PT J
AU Polakowski, LL
Akinbami, LJ
Mendola, P
AF Polakowski, Laura L.
Akinbami, Lara J.
Mendola, Pauline
TI Prenatal Smoking Cessation and the Risk of Delivering Preterm and
Small-for-Gestational-Age Newborns
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
ID LOW-BIRTH-WEIGHT; INTRAUTERINE GROWTH-RETARDATION; MATERNAL SMOKING;
FETAL-GROWTH; PREGNANCY; OUTCOMES; TERM; RESTRICTION; ASSOCIATION;
MORTALITY
AB OBJECTIVE: To examine the association between prenatal smoking cessation and delivery of a preterm or small-for-gestational-age (SGA) newborn in a large U.S. subpopulation using the revised (2003) birth certificate, which now assesses maternal smoking status by trimester.
METHODS: We analyzed a cohort of U.S.-resident, singleton births in the 11 states that used the revised birth certificate in 2005 (n=915,441). Self-reported maternal smoking status was categorized as "never smoked," "quit in the first trimester," "quit in the second trimester," and "smoked throughout" pregnancy (referent). Multinomial logistic regression was used to estimate adjusted odds ratios (aORs) for three outcomes (preterm non-SGA, term SGA, or preterm SGA newborns) by maternal smoking status. Analyses stratified by maternal age were also conducted.
RESULTS: Compared with women who smoked throughout pregnancy, first-trimester quitters reduced their odds of delivering a preterm non-SGA newborn by 31% (aOR 0.69, 95% confidence interval [CI] 0.65-0.74), a term SGA newborn by 55% (aOR 0.45, 95% CI 0.42-0.48), and a preterm SGA newborn by 53% (aOR 0.47, 95% Cl 0.40-0.55), similar to nonsmokers. Second-trimester quitters also reduced their odds of delivering preterm non-SGA and term SGA newborns but to a lesser magnitude. When comparing first-trimester quitters with smokers in each age group, older mothers had generally lower odds of these outcomes than younger mothers.
CONCLUSION: Pregnant smokers who quit in the first trimester lowered their risk of delivering preterm and SGA newborns to a level similar to that of pregnant nonsmokers, and this benefit appeared to increase with maternal age. These findings reinforce current clinical guidance to encourage smoking cessation among pregnant smokers and serve as an additional incentive to quit. (Obstet Gynecol 2009;114:318-25)
C1 Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA.
[Polakowski, Laura L.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
US PHS, Rockville, MD USA.
RP Akinbami, LJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 6111, Hyattsville, MD 20782 USA.
EM Akinbami@cdc.gov
OI Mendola, Pauline/0000-0001-5330-2844
NR 37
TC 31
Z9 31
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD AUG
PY 2009
VL 114
IS 2
BP 318
EP 325
PG 8
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 476DO
UT WOS:000268418200017
PM 19622993
ER
PT J
AU Culwell, KR
Curtis, KM
Cravioto, MD
AF Culwell, Kelly R.
Curtis, Kathryn M.
del Carmen Cravioto, Maria
TI Safety of Contraceptive Method Use Among Women With Systemic Lupus
Erythematosus A Systematic Review
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Review
ID ANTIPHOSPHOLIPID ANTIBODIES; ORAL-CONTRACEPTIVES; THROMBOSIS; DISEASE;
COHORT; RISK; NEPHRITIS; PREGNANCY; MORTALITY; SLE
AB OBJECTIVE: To evaluate the evidence on the safety of contraceptive method use among women with systemic lupus erythematosus (SLE).
DATA SOURCES: We searched the PubMed, MEDLINE, and LILACS databases for peer-reviewed articles published from database inception through January 2009, concerning the safety of contraceptive use among women with SLE.
METHODS OF STUDY SELECTION: We included studies that examined health outcomes among women using a contraceptive method after the diagnosis of SLE. The quality of each individual piece of evidence was assessed using the U.S. Preventive Services Task Force grading system.
TABULATION, INTEGRATION, AND RESULTS: Our search yielded 275 articles. A total of 14 articles that reported on 13 studies met our inclusion criteria. Available evidence, including two good-quality randomized controlled trials, indicates that use of combined oral contraceptives does not lead to increased flares of disease or worsening disease activity in women with inactive or stable active SLE. No increase in disease activity with use of progestogen-only contraceptives was noted in four studies. Limited evidence indicates a possible increased risk of thrombosis in women with positive anti phospholipid antibodies and history of oral contraceptive use. Limited evidence indicates that the use of the copper intrauterine device is not associated with worsening disease activity or infection in women with SLE.
CONCLUSION: Available evidence indicates that many women with SLE can be considered good candidates for most contraceptive methods, including hormonal contraceptives. The benefits of contraception for many women with SLE likely outweigh the risks of unintended pregnancy in this population. Women with positive antiphospholipid antibodies are not good candidates for combined hormonal contraception given their elevated baseline risk of thrombosis. (Obstet Gynecol 2009,114:341-53)
C1 [Culwell, Kelly R.] WHO, Dept Reprod Hlth & Res, CH-1211 Geneva 27, Switzerland.
Ctr Dis Control & Prevent, Atlanta, GA USA.
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City, DF, Mexico.
RP Culwell, KR (reprint author), WHO, Dept Reprod Hlth & Res, 20 Ave Appia, CH-1211 Geneva 27, Switzerland.
EM culwellk@who.int
FU World Health Organization (Geneva, Switzerland); Centers for Disease
Control and Prevention (Atlanta, GA); U.S. Agency for International
Development (Washington, DC); Eunice Kennedy Shriver National Institute
of Child Health and Human Development (Rockville, MD)
FX Supported by resources from the World Health Organization (Geneva,
Switzerland), the Centers for Disease Control and Prevention (Atlanta,
GA), the U.S. Agency for International Development (Washington, DC), and
the Eunice Kennedy Shriver National Institute of Child Health and Human
Development (Rockville, MD).
NR 32
TC 35
Z9 39
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD AUG
PY 2009
VL 114
IS 2
BP 341
EP 353
PG 13
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 476DO
UT WOS:000268418200020
PM 19622996
ER
PT J
AU Graczyk, TK
Lucy, FE
Mashinsky, Y
Thompson, RCA
Koru, O
daSilva, AJ
AF Graczyk, Thaddeus K.
Lucy, Frances E.
Mashinsky, Yessika
Thompson, R. C. Andrew
Koru, Ozgur
daSilva, Alexandre J.
TI Human zoonotic enteropathogens in a constructed free-surface flow
wetland
SO PARASITOLOGY RESEARCH
LA English
DT Article
ID TARGETED OLIGONUCLEOTIDE PROBE; POLYMERASE CHAIN-REACTION; SUBUNIT
RIBOSOMAL-RNA; WASTE-WATER; INDICATOR MICROORGANISMS;
CRYPTOSPORIDIUM-PARVUM; SEWAGE-SLUDGE; GIARDIA-LAMBLIA; REMOVAL;
PATHOGENS
AB Effluents from a small-scale free-surface flow constructed wetland, used for polishing of secondary treated wastewater, contained significantly higher concentrations of potentially viable Giardia duodenalis cysts and Enterocytozoon bieneusi spores than did wetland influents consisting of secondary treated wastewater. Zoonotic Assemblage A of G. duodenalis cysts was identified in wetland inflows, while Assemblage A and two nonhuman infective Assemblages (i.e., C, and E) were present in wetland effluents. E. bieneusi spores represented genotype K based on DNA sequencing analysis of internal transcribed spacer. The study demonstrated that: (1) free-surface flow small-scale constructed wetlands may not provide sufficient remediation for human zoonotic protozoa and fungi present in secondary treated wastewater; (2) dogs and livestock can substantially contribute human-pathogenic protozoan and fungal microorganisms to engineered vegetated wetland systems; and (3) large volumes of wetland effluents can contribute to contamination of surface waters used for recreation and drinking water abstraction and therefore represent a serious public health threat.
C1 [Graczyk, Thaddeus K.; Mashinsky, Yessika] Johns Hopkins Bloomberg Sch Publ Hlth, Div Environm Hlth Engn, Dept Environm Hlth Sci, Baltimore, MD 21205 USA.
[Graczyk, Thaddeus K.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA.
[Graczyk, Thaddeus K.] Johns Hopkins Bloomberg Sch Publ Hlth, Johns Hopkins Ctr Water & Hlth, Baltimore, MD 21205 USA.
[Lucy, Frances E.] Inst Technol, Sch Sci, Dept Environm Sci, Sligo, Ireland.
[Graczyk, Thaddeus K.; Lucy, Frances E.] Inst Technol, Sch Sci, Ctr Biomol Environm & Publ Hlth Res, Sligo, Ireland.
[Lucy, Frances E.] Environm Serv Ireland, Carrick On Shannon, Leitrim, Ireland.
[Thompson, R. C. Andrew] Murdoch Univ, Sch Vet & Biomed Sci, WHO Collaborating Ctr Mol Epidemiol Parasit Infec, Murdoch, WA 6150, Australia.
[Koru, Ozgur; daSilva, Alexandre J.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Publ Hlth Serv,US Dept Hlth & Publ Serv, Atlanta, GA 30341 USA.
RP Graczyk, TK (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Div Environm Hlth Engn, Dept Environm Hlth Sci, Baltimore, MD 21205 USA.
EM tgraczyk@jhsph.edu
FU Fulbright Senior Specialist Fellowship [2225]; Johns Hopkins Center in
Urban Environmental Health [P30 ES03819]; School of Science Institute of
Technology; US Environmental Protection Agency Science to Achieve
Results (STAR) Program [RD83300201]
FX The study was supported by the Fulbright Senior Specialist Fellowship
(grant no. 2225 Graczyk), Johns Hopkins Center in Urban Environmental
Health (grant no. P30 ES03819), School of Science Institute of
Technology, Sligo, Ireland, and the US Environmental Protection Agency
Science to Achieve Results (STAR) Program (grant no. RD83300201). The
views expressed herein have not been subjected to the US EPA review and
therefore do not necessarily reflect the views of the agency, and no
official endorsement should be inferred. We acknowledge Roscommon County
Council for access and samples from sewage treatment plant.
NR 38
TC 9
Z9 9
U1 3
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0932-0113
J9 PARASITOL RES
JI Parasitol. Res.
PD AUG
PY 2009
VL 105
IS 2
BP 423
EP 428
DI 10.1007/s00436-009-1400-6
PG 6
WC Parasitology
SC Parasitology
GA 461UJ
UT WOS:000267297300017
PM 19343366
ER
PT J
AU Gould, PL
Leung, J
Scott, C
Schmid, DS
Deng, H
Lopez, A
Chaves, SS
Reynolds, M
Gladden, L
Harpaz, R
Snow, S
AF Gould, Philip L.
Leung, Jessica
Scott, Connie
Schmid, D. Scott
Deng, Helen
Lopez, Adriana
Chaves, Sandra S.
Reynolds, Meredith
Gladden, Linda
Harpaz, Rafael
Snow, Sandra
TI An Outbreak of Varicella in Elementary School Children With Two-Dose
Varicella Vaccine Recipients-Arkansas, 2006
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
DE varicella; outbreak; 2-dose varicella vaccine
ID UNITED-STATES; HOSPITALIZATIONS; EXPERIENCE; STRAINS; DECLINE; MAINE
AB Background: In June 2006, the Advisory Committee on Immunization Practices (ACIP) expanded its June 2005 recommendation for a second dose of varicella vaccine during outbreaks to a recommendation for routine school entry second dose varicella vaccination. In October 2006, the Arkansas Department of Health was notified of a varicella outbreak among students where some received a second dose during an outbreak-related vaccination campaign in February 2006.
Methods: The outbreak was investigated using a school-wide parental survey with a follow-up survey of identified case patients. Vaccination status was verified using state and local immunization records. Limited laboratory testing confirmed circulation of wild-type varicella, including varicella in 2-dose vaccine recipients.
Results: Vaccination information was available for 871 (99%) of the 880 children. Varicella vaccination coverage was 97% (2-dose, 39%; 1-dose, 58%). A review of the February vaccination clinic found no deficiencies lot numbers did not differ between cases and noncases. Varicella was confirmed by PCR in 5 (42%) of 12 lesion specimen; and by IgM in 1 (6%) of 16 serum specimens. Varicella was reported in 84 children, including 25 (30%) two-dose and 53 (63%) one-dose recipients. Attack rates among 2-dose recipients (10.4%) and 1-dose recipients (14.6%) were not significantly different (RR: 0.72, 95% CI: 0.44-1.15). All 2-dose recipients and 80% of 1-dose recipients reported having 50 or fewer skin lesions.
Conclusion: This outbreak is the first to document varicella in both 1- and 2-dose vaccine recipients; both groups had mild disease. The vaccine effectiveness of 1 and 2 doses were similar.
C1 [Gould, Philip L.] Ctr Dis Control & Prevent, Epidemiol Program Off, Atlanta, GA USA.
[Gould, Philip L.; Leung, Jessica; Lopez, Adriana; Chaves, Sandra S.; Reynolds, Meredith; Harpaz, Rafael] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Scott, Connie] Arkansas Dept Hlth, Ashley Cty Hlth Unit, Hamburg, AR USA.
[Schmid, D. Scott] Ctr Dis Control & Prevent, Natl Varicella Zoster Virus Lab, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Deng, Helen] Arkansas Dept Hlth, Publ Hlth Lab, Little Rock, AR 72205 USA.
RP Gould, PL (reprint author), 110 Luke Ave,Rm 405, Washington, DC 20032 USA.
EM Philip.gould@pentagon.af.mil
NR 20
TC 25
Z9 25
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0891-3668
EI 1532-0987
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD AUG
PY 2009
VL 28
IS 8
BP 678
EP 681
DI 10.1097/INF.0b013e31819c1041
PG 4
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA 477QG
UT WOS:000268533000004
PM 19593254
ER
PT J
AU Millar, EV
O'Brien, KL
Zell, ER
Bronsdon, MA
Reid, R
Santosham, M
AF Millar, Eugene V.
O'Brien, Katherine L.
Zell, Elizabeth R.
Bronsdon, Melinda A.
Reid, Raymond
Santosham, Mathuram
TI Nasopharyngeal Carriage of Streptococcus pneumoniae in Navajo and White
Mountain Apache Children Before the Introduction of Pneumococcal
Conjugate Vaccine
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
DE pneumococcus; Streptococcus pneumoniae; nasopharyngeal carriage;
American Indian
ID ANTIBIOTIC-RESISTANT PNEUMOCOCCI; UPPER RESPIRATORY-TRACT; ACUTE
OTITIS-MEDIA; PAPUA-NEW-GUINEA; 1ST 2 YEARS; HAEMOPHILUS-INFLUENZAE;
HEALTHY-CHILDREN; RANDOMIZED-TRIAL; UNITED-STATES; DAY-CARE
AB Background: Infants and children are frequently colonized with pneumococcus. Recent nasopharyngeal acquisition of pneumococcus is thought to precede disease episodes. The increased risk of pneumococcal disease among Navajo and White Mountain Apache populations has been documented. Little is known about the dynamics of pneumococcal carriage in these populations.
Methods: A group randomized, controlled trial of 7-valent conjugate pneumococcal vaccine (PnCRM7, Wyeth) was conducted on the Navajo and Apache reservations. A nasopharyngeal (NP) carriage study was nested in the trial to evaluate the impact of PnCRM7 on carriage. Children <6 years of age had NP swabs collected at enrollment and at 6 and 12 months following enrollment. We analyzed carriage data from children in control vaccine randomized communities to describe the epidemiology of pneumococcal carriage.
Results: Of the 410 participants enrolled, 92% were colonized with pneumococcus at least once during the course of the study. Sixty-three percent of NP specimens were positive for pneumococcus. The most common serotypes were 6A, 6B, nontypable, 23F, 14, 19F, 19A, and 9V. Thirty-eight percent of isolates were vaccine serotypes. Age <2 years, male sex, daycare attendance, and having a sibling colonized with pneumococcus were associated with an increased risk of carriage.
Conclusions: The high carriage prevalence among Navajo and Apache children reflects an intense exposure to pneumococcus. The lack of modifiable risk factors for carriage highlights the importance of preventive strategies for disease control.
C1 [Millar, Eugene V.; O'Brien, Katherine L.; Bronsdon, Melinda A.; Reid, Raymond; Santosham, Mathuram] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Amer Indian Hlth, Baltimore, MD USA.
[Zell, Elizabeth R.] Ctr Dis Control & Prevent, Div Bacterial Res, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
RP Millar, EV (reprint author), 621 N Washington St, Baltimore, MD 21205 USA.
EM emillar@jhsph.edu
NR 39
TC 27
Z9 27
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0891-3668
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD AUG
PY 2009
VL 28
IS 8
BP 711
EP 716
DI 10.1097/INF.0b013e3181a06303
PG 6
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA 477QG
UT WOS:000268533000011
PM 19593248
ER
PT J
AU Greenwald, R
Ferdinands, JM
Teague, WG
AF Greenwald, Roby
Ferdinands, Jill M.
Teague, W. Gerald
TI Ionic Determinants of Exhaled Breath Condensate pH Before and After
Exercise in Adolescent Athletes
SO PEDIATRIC PULMONOLOGY
LA English
DT Article
DE ammonia; acetic acid; propionic acid; exercise; ion chromatography;
deaeration
ID BLOOD AMMONIA; SPECTROMETRY; LACTATE; PLAYERS; LIQUID; ASTHMA; MUSCLE;
ACIDS; SWEAT; UREA
AB Background: The pH of exhaled breath condensate (EBC) of adolescent athletes engaged in vigorous physical activity is low compared to healthy controls; however, the ionic determinants of EBC pH and the acute effects of exercise on those determinants have not been definitively established. Objectives: This study had two purposes: (1) to identify the ionic composition of EBC before and after exercise, and (2) to examine the effects of sample deaeration on EBC pH and composition. Methods: EBC ionic composition was determined by ion chromatography and correlated with pH measured before and after deaeration. Bicarbonate concentration was calculated from the ion balance of other measured species and pH. Results: EBC pH displayed a bimodal distribution, included values lower than expected for healthy individuals, and was correlated exclusively with volatile species, namely ammonia (mean concentration = 215 mu M) and acetic (31.7 mu M) and propionic acids (10.0 mu M). Following exercise, raw EBC pH and ammonia concentration increased while propionic acid concentration fell. Following deaeration, EBC pH increased by one unit on average; however, the pH of samples with unusually low pH did not change significantly, and the concentrations of several ionic species were altered in a manner that cannot be explained in terms of volatility. Conclusions: We conclude that in healthy adolescents, exercise results in an acute increase in raw EBC pH in association with an increase in ammonium and a decrease in propionate concentration. Since exercise increases systemic ammonia and urea (which is hydrolyzed by oral bacteria to form ammonia), we propose that the likely source of these changes is gas-phase diffusion from epithelial and oral surface liquids and to a lesser extent, from pulmonary circulation. Pediatr Pulmonol. 2009; 44:768-777. (C) 2009 Wiley-Liss, Inc.
C1 [Greenwald, Roby; Teague, W. Gerald] Emory Univ, Sch Med, Dept Pediat, Div Pulm Allergy Cyst Fibrosis & Sleep Med, Atlanta, GA 30322 USA.
[Ferdinands, Jill M.] Ctr Dis Control & Prevent, Air Pollut & Resp Hlth Branch, Atlanta, GA USA.
RP Greenwald, R (reprint author), Emory Univ, Dept Environm & Occupat Hlth, Rollins Sch Publ Hlth, 1518 Clifton Rd, Atlanta, GA 30322 USA.
EM roby.greenwald@emory.edu
FU Centers for Disease Control and Prevention [U48 DP000043-02];
Southeastern Region American Lung Association (Asthma Clinical Research
Centers)
FX Grant sponsor: Centers for Disease Control and Prevention Grant number:
U48 DP000043-02. Grant sponsor: Southeastern Region American Lung
Association (Asthma Clinical Research Centers)
NR 30
TC 26
Z9 26
U1 2
U2 11
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 8755-6863
J9 PEDIATR PULM
JI Pediatr. Pulmonol.
PD AUG
PY 2009
VL 44
IS 8
BP 768
EP 777
DI 10.1002/ppul.21055
PG 10
WC Pediatrics; Respiratory System
SC Pediatrics; Respiratory System
GA 480CM
UT WOS:000268709500006
PM 19598280
ER
PT J
AU Tate, JE
Panozzo, CA
Payne, DC
Patel, MM
Cortese, MM
Fowlkes, AL
Parashar, UD
AF Tate, Jacqueline E.
Panozzo, Catherine A.
Payne, Daniel C.
Patel, Manish M.
Cortese, Margaret M.
Fowlkes, Ashley L.
Parashar, Umesh D.
TI Decline and Change in Seasonality of US Rotavirus Activity After the
Introduction of Rotavirus Vaccine
SO PEDIATRICS
LA English
DT Article
DE rotavirus; acute gastroenteritis; vaccination
ID UNITED-STATES; CHILDREN; HOSPITALIZATIONS; GASTROENTERITIS; TRENDS;
DIARRHEA; INFANTS
AB BACKGROUND: In 2006, routine immunization of US infants against rotavirus was initiated. We assessed national, regional, and local trends in rotavirus testing and detection before and after vaccine introduction.
METHODS: We examined data for July 2000 through June 2008 from a national network of similar to 70 US laboratories to compare geographical and temporal aspects of rotavirus season timing and peak activity. To assess trends in rotavirus testing and detection, we restricted the analyses to 33 laboratories that reported for >= 26 weeks per season from 2000 to 2008.
RESULTS: Nationally, the onset and peak of the 2007-2008 rotavirus season were delayed 15 and 8 weeks, respectively, compared with prevaccine seasons from 2000-2006. Delays were observed in each region. The 2007-2008 rotavirus season lasted 14 weeks compared with a median of 26 weeks during the prevaccine era. Of 33 laboratories, 32 reported fewer positive results and a lower proportion of positive test results in 2007-2008 compared with the median in 2000-2006, with a 67% decline in the number and a 69% decline in the proportion of rotavirus-positive test results. The proportion of positive test results in 2007-2008 compared with the median in 2000-2006 declined >50% in 79% of the laboratories and >75% in 39% of the laboratories.
CONCLUSIONS: The 2007-2008 US rotavirus season seems substantially delayed, shorter, and diminished in magnitude compared with seasons before vaccine implementation. The extent of change seems greater than expected on the basis of estimated vaccine coverage, suggesting indirect benefits to unvaccinated individuals. Monitoring in future seasons is needed to confirm these trends. Pediatrics 2009; 124: 465-471
C1 [Tate, Jacqueline E.; Panozzo, Catherine A.; Payne, Daniel C.; Patel, Manish M.; Cortese, Margaret M.; Fowlkes, Ashley L.; Parashar, Umesh D.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA.
RP Tate, JE (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, 1600 Clifton Rd NE,MS A47, Atlanta, GA 30333 USA.
EM jqt8@cdc.gov
NR 18
TC 128
Z9 130
U1 0
U2 6
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD AUG
PY 2009
VL 124
IS 2
BP 465
EP 471
DI 10.1542/peds.2008-3528
PG 7
WC Pediatrics
SC Pediatrics
GA 475RC
UT WOS:000268377000004
PM 19581260
ER
PT J
AU Gaur, AH
Dominguez, KL
Kalish, ML
Rivera-Hernandez, D
Donohoe, M
Brooks, JT
Mitchell, CD
AF Gaur, Aditya H.
Dominguez, Kenneth L.
Kalish, Marcia L.
Rivera-Hernandez, Delia
Donohoe, Marion
Brooks, John T.
Mitchell, Charles D.
TI Practice of Feeding Premasticated Food to Infants: A Potential Risk
Factor for HIV Transmission
SO PEDIATRICS
LA English
DT Article
DE HIV; feeding; premastication; prechewed; child
ID RURAL NORTHERN THAILAND; TO-CHILD TRANSMISSION; BACTERIAL CONTENT;
VIRUS-INFECTION; CARE PRACTICES; WEANING FOODS; PREVENTION; DNA
AB OBJECTIVES: Although some caregivers are known to premasticate food for infants, usually during the weaning period, HIV transmission has not been linked to this practice. We describe 3 cases of HIV transmission in the United States possibly related to this practice.
PATIENTS AND METHODS: Three cases of HIV infection were diagnosed in children at ages 9, 15, and 39 months; clinical symptomatology prompted the testing. A thorough investigation to rule out alternative modes of transmission was conducted. In addition, phylogenetic comparisons of virus from cases and suspected sources were performed by using the C2V3C3 or gp41 region of env and the p17 coding region of gag.
RESULTS: In 2 cases, the mothers were known to be infected with HIV, had not breastfed their children, and perinatal transmission of HIV had previously been ruled out following US HIV testing guidelines. In the third case, a great aunt who helped care for the child was infected with HIV, but the child's mother was not. All 3 children were fed food on multiple occasions that had been premasticated by a care provider infected with HIV; in 2 cases concurrent oral bleeding in the premasticating adult was described. Phylogenetic analyses supported the epidemiologic conclusion that the children were infected through exposure to premasticated food from a caregiver infected with HIV in 2 of the 3 cases.
CONCLUSIONS: The reported cases provide compelling evidence linking premastication to HIV infection, a route of transmission not previously reported that has important global implications including being a possible explanation for some of the reported cases of "late" HIV transmission in infants, so far attributed to breastfeeding. Until the risk of premastication and modifying factors (eg, periodontal disease) are better understood, we recommend that health care providers routinely query children's caregivers and expecting parents who are infected with HIV or at risk of HIV infection about this feeding practice and direct them to safer, locally available, feeding options. Pediatrics 2009; 124: 658-666
C1 [Gaur, Aditya H.; Donohoe, Marion] St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA.
[Dominguez, Kenneth L.; Brooks, John T.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA.
[Kalish, Marcia L.] Ctr Dis Control & Prevent, Div Aids, STD, Atlanta, GA USA.
[Kalish, Marcia L.] Ctr Dis Control & Prevent, TB Lab Res, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
[Rivera-Hernandez, Delia; Mitchell, Charles D.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
RP Gaur, AH (reprint author), St Jude Childrens Hosp, Dept Infect Dis, MS 600,262 Danny Thomas Pl, Memphis, TN 38105 USA.
EM aditya.gaur@stjude.org
NR 32
TC 35
Z9 38
U1 0
U2 1
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD AUG
PY 2009
VL 124
IS 2
BP 658
EP 666
DI 10.1542/peds.2008-3614
PG 9
WC Pediatrics
SC Pediatrics
GA 475RC
UT WOS:000268377000028
PM 19620190
ER
PT J
AU Broussard, CS
Goodman, KJ
Phillips, CV
Smith, MA
Fischbach, LA
Day, RS
Aragaki, CC
AF Broussard, Cheryl S.
Goodman, Karen J.
Phillips, Carl V.
Smith, Mary Ann
Fischbach, Lori A.
Day, R. Sue
Aragaki, Corinne C.
TI Antibiotics taken for other illnesses and spontaneous clearance of
Helicobacter pylori infection in children
SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
LA English
DT Article
DE Helicobacter pylori; spontaneous clearance; antibiotics; children
ID UREA BREATH TEST; MEXICO BIRTH COHORT; 1ST 2 YEARS; NATURAL-HISTORY;
EARLY-CHILDHOOD; EARLY-LIFE; FOLLOW-UP; EPIDEMIOLOGY; ACQUISITION;
DIAGNOSIS
AB Purpose Factors that determine persistence of untreated Helicobacter pylori (H, pylori) infection in childhood are not well understood. We estimated risk differences for the effect of incidental antibiotic exposure on the probability of a detected clearance at the next test after an initial detected H. pylori infection.
Methods The Pasitos Cohort Study (1998-2005) investigated predictors of H. pylori infection in children from El Paso, Texas, and Juarez, Mexico. Children were screened for infection at 6-month target intervals from 6 to 84 months of age, using the 13 C-urea breath test corrected for body-size-dependent variation in CO2 production. Exposure was defined as courses of any systemic antibiotic (systemic) or those with anti-H. pylori action (HP-effective) reported for the interval between initial detected infection and next test. Binomial regression models included country of residence, mother's education, adequacy of prenatal care, age at infection, and interval between tests.
Results Of 205 children with a test result and antibiotic data following a detected infection, the number of children who took > 1 course in the interval between tests was 74 for systemic and 33 for HP-effective. The proportion testing negative at the next test was 66% for 0 courses, 72% for >= 1 systemic course, and 79% for >= 1 HP-effective course. Adjusted risk differences (95%Cl) for apparent clearance, comparing > 1 to 0 courses were 10% (1-20%) for systemic and 11% (0-21%) for HP-effective.
Conclusions Incidental antibiotic exposure appears to influence the duration of childhood H. pylori infection but seems to explain only a small portion of spontaneous clearance. Copyright (C) 2009 John Wiley & Sons, Ltd.
C1 [Broussard, Cheryl S.; Smith, Mary Ann; Day, R. Sue; Aragaki, Corinne C.] Univ Texas Sch Publ Hlth, Houston, TX USA.
[Goodman, Karen J.; Phillips, Carl V.] Univ Alberta, Dept Med, Edmonton, AB, Canada.
[Goodman, Karen J.; Phillips, Carl V.] Univ Alberta, Dept Publ Hlth, Edmonton, AB, Canada.
[Fischbach, Lori A.] Univ N Texas Hlth Sci Ctr, Ft Worth, TX USA.
RP Broussard, CS (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,MS E-86, Atlanta, GA 30333 USA.
EM gnp2@cdc.gov
RI Goodman, Karen/D-6823-2013
OI Goodman, Karen/0000-0002-3790-3217
FU National Institute for Diabetes and Digestive and Kidney Diseases
[ROIDKO53664]
FX We thank the Pasitos Cohort Study participants, Flor Puentes, Lupe
Garcia, and members of the 2006 SER Student Workshop for their
contributions to this project. This work was funded by the National
Institute for Diabetes and Digestive and Kidney Diseases (ROIDKO53664).
NR 44
TC 15
Z9 15
U1 0
U2 0
PU WILEY PERIODICALS, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA
SN 1053-8569
J9 PHARMACOEPIDEM DR S
JI Pharmacoepidemiol. Drug Saf.
PD AUG
PY 2009
VL 18
IS 8
BP 722
EP 729
DI 10.1002/pds.1773
PG 8
WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
GA 483YO
UT WOS:000269009600011
PM 19455592
ER
PT J
AU Broussard, CS
Rasmussen, SA
Reefhuis, J
Friedman, JM
Jann, MW
Honein, MA
AF Broussard, C. S.
Rasmussen, S. A.
Reefhuis, J.
Friedman, J. -M.
Jann, M. W.
Honein, M. A.
TI Early-Pregnancy Opioid Analgesic Treatment and Risk for Congenital Heart
Defects
SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
LA English
DT Meeting Abstract
C1 [Broussard, C. S.; Rasmussen, S. A.; Reefhuis, J.; Honein, M. A.] CDC, Atlanta, GA 30333 USA.
[Friedman, J. -M.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
[Jann, M. W.] Mercer Univ, Atlanta, GA USA.
RI Reefhuis, Jennita/E-1793-2011
OI Reefhuis, Jennita/0000-0002-4747-4831
NR 0
TC 0
Z9 0
U1 0
U2 0
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1053-8569
J9 PHARMACOEPIDEM DR S
JI Pharmacoepidemiol. Drug Saf.
PD AUG
PY 2009
VL 18
BP S199
EP S200
PG 2
WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
GA 483YQ
UT WOS:000269009900455
ER
PT J
AU Huang, WT
Gargiullo, P
Shui, I
Weintraub, E
Baggs, J
Broder, K
Iskander, J
AF Huang, Wan-Ting
Gargiullo, Paul
Shui, Irene
Weintraub, Eric
Baggs, James
Broder, Karen
Iskander, John
TI The Risk of Seizures after Acellular Pertussis Vaccines in Early
Childhood-United States, 2002-2006
SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
LA English
DT Meeting Abstract
C1 [Huang, Wan-Ting; Gargiullo, Paul; Weintraub, Eric; Baggs, James; Broder, Karen; Iskander, John] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Shui, Irene] Harvard Pilgrim Hlth Care, Boston, MA USA.
[Shui, Irene] Harvard Univ, Sch Med, Boston, MA USA.
RI Huang, Wan-Ting/E-3497-2010
OI Huang, Wan-Ting/0000-0002-4344-9567
NR 0
TC 0
Z9 0
U1 0
U2 0
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1053-8569
J9 PHARMACOEPIDEM DR S
JI Pharmacoepidemiol. Drug Saf.
PD AUG
PY 2009
VL 18
BP S25
EP S26
PG 2
WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
GA 483YQ
UT WOS:000269009900058
ER
PT J
AU M'ikanatha, NM
Bodeis-Jones, S
Lautenbach, E
Zhao, SH
Folster, JP
Medalla, FM
Localio, AR
Russo, AT
Reynolds, S
McDermott, PF
AF M'ikanatha, Nkuchia M.
Bodeis-Jones, Sonya
Lautenbach, Ebbing
Zhao, Shaohua
Folster, Jason P.
Medalla, Felicita M.
Localio, A. Russell
Russo, Anthony T.
Reynolds, Stanley
McDermott, Patrick F.
TI Comparison of Fluoroquinolone and Macrolide Resistance in Campylobacter
from Retail Chicken Meat in Pennsylvania with National Data
SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
LA English
DT Meeting Abstract
C1 [M'ikanatha, Nkuchia M.] Penn Dept Hlth, Harrisburg, PA 17108 USA.
[M'ikanatha, Nkuchia M.; Lautenbach, Ebbing; Localio, A. Russell] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
[Bodeis-Jones, Sonya; Zhao, Shaohua; McDermott, Patrick F.] US FDA, Ctr Vet Med, Laurel, MD USA.
[Folster, Jason P.; Medalla, Felicita M.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Localio, A. Russell] Penn Dept Agr, Harrisburg, PA USA.
[Reynolds, Stanley] Penn Dept Hlth, Bur Labs, Exton, PA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1053-8569
J9 PHARMACOEPIDEM DR S
JI Pharmacoepidemiol. Drug Saf.
PD AUG
PY 2009
VL 18
BP S215
EP S216
PG 2
WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
GA 483YQ
UT WOS:000269009900492
ER
PT J
AU Yih, WK
Fireman, B
Klein, N
Kulldorff, M
Lewis, E
Lieu, T
Weintraub, E
Platt, R
AF Yih, W. K.
Fireman, B.
Klein, N.
Kulldorff, M.
Lewis, E.
Lieu, T.
Weintraub, E.
Platt, R.
TI Near Real-Time Post-Marketing Surveillance: The Experience of the
Vaccine Safety Datalink
SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
LA English
DT Meeting Abstract
C1 [Yih, W. K.; Kulldorff, M.; Lieu, T.; Platt, R.] Harvard Univ, Sch Med, Boston, MA USA.
[Yih, W. K.; Kulldorff, M.; Lieu, T.; Platt, R.] Harvard Pilgrim Hlth Care, Boston, MA USA.
[Fireman, B.; Klein, N.; Lewis, E.] Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA.
[Weintraub, E.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1053-8569
J9 PHARMACOEPIDEM DR S
JI Pharmacoepidemiol. Drug Saf.
PD AUG
PY 2009
VL 18
BP S5
EP S6
PG 2
WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
GA 483YQ
UT WOS:000269009900013
ER
PT J
AU Pakula, AT
Braun, KV
Yeargin-Allsopp, M
AF Pakula, Amy Thornhill
Braun, Kim Van Naarden
Yeargin-Allsopp, Marshalyn
TI Cerebral Palsy: Classification and Epidemiology
SO PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA
LA English
DT Review
DE Epidemiology; Cerebral palsy; Prevalence; Risk factors; Surveillance
ID BIRTH-WEIGHT INFANTS; URINARY-TRACT DYSFUNCTION; GROSS MOTOR FUNCTION;
PRETERM INFANTS; CHILDREN BORN; NEURODEVELOPMENTAL OUTCOMES;
DEVELOPMENTAL-DISABILITIES; LESS-THAN-32 WEEKS; CHANGING PANORAMA;
RISK-FACTORS
AB This article reviews the historical background, classification, and etiology of cerebral palsy (CP), the most common motor disability of childhood. The various methods employed to measure the prevalence of CP in the population are examined. Causes of CP are numerous, and the etiology multi-factorial. Risk factors are categorized by the timing of their proposed occurrence: prenatal, perinatal, and postnatal. The leading prenatal and perinatal risk factors for CP are birth weight and gestational age. Other risk factors include neonatal encephalopathy, multiple pregnancy, infection and inflammation, and a variety of genetic factors.
C1 [Braun, Kim Van Naarden; Yeargin-Allsopp, Marshalyn] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Pakula, Amy Thornhill] Emory Univ, Dept Pediat, Marcus Autism Ctr, Atlanta, GA 30329 USA.
RP Yeargin-Allsopp, M (reprint author), CDC, Natl Ctr Birth Defects & Dev Disabil, MS E-86,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM mxy1@cdc.gov
NR 126
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U1 2
U2 21
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1047-9651
J9 PHYS MED REHABIL CLI
JI Phys. Med. Rehabil. Clin. N. Am.
PD AUG
PY 2009
VL 20
IS 3
BP 427
EP +
DI 10.1016/j.pmr.2009.06.001
PG 29
WC Rehabilitation
SC Rehabilitation
GA 489QI
UT WOS:000269435800003
PM 19643346
ER
PT J
AU Melman, SD
Steinauer, ML
Cunningham, C
Kubatko, LS
Mwangi, IN
Wynn, NB
Mutuku, MW
Karanja, DMS
Colley, DG
Black, CL
Secor, WE
Mkoji, GM
Loker, ES
AF Melman, Sandra D.
Steinauer, Michelle L.
Cunningham, Charles
Kubatko, Laura S.
Mwangi, Ibrahim N.
Wynn, Nirvana Barker
Mutuku, Martin W.
Karanja, Diana M. S.
Colley, Daniel G.
Black, Carla L.
Secor, William Evan
Mkoji, Gerald M.
Loker, Eric S.
TI Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan
Isolates of Schistosoma mansoni
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID OCCUPATIONALLY EXPOSED ADULTS; DRUG-RESISTANCE; CURE RATES; EGYPTIAN
VILLAGERS; PARASITIC DISEASES; WESTERN KENYA; IN-VIVO; SENSITIVITY;
INFECTIONS; SENEGAL
AB Background: The near exclusive use of praziquantel (PZQ) for treatment of human schistosomiasis has raised concerns about the possible emergence of drug-resistant schistosomes.
Methodology/Principal Findings: We measured susceptibility to PZQ of isolates of Schistosoma mansoni obtained from patients from Kisumu, Kenya continuously exposed to infection as a consequence of their occupations as car washers or sand harvesters. We used a) an in vitro assay with miracidia, b) an in vivo assay targeting adult worms in mice and c) an in vitro assay targeting adult schistosomes perfused from mice. In the miracidia assay, in which miracidia from human patients were exposed to PZQ in vitro, reduced susceptibility was associated with previous treatment of the patient with PZQ. One isolate ("KCW'') that was less susceptible to PZQ and had been derived from a patient who had never fully cured despite multiple treatments was studied further. In an in vivo assay of adult worms, the KCW isolate was significantly less susceptible to PZQ than two other isolates from natural infections in Kenya and two lab-reared strains of S. mansoni. The in vitro adult assay, based on measuring length changes of adults following exposure to and recovery from PZQ, confirmed that the KCW isolate was less susceptible to PZQ than the other isolates tested. A sub-isolate of KCW maintained separately and tested after three years was susceptible to PZQ, indicative that the trait of reduced sensitivity could be lost if selection was not maintained.
Conclusions/Significance: Isolates of S. mansoni from some patients in Kisumu have lower susceptibility to PZQ, including one from a patient who was never fully cured after repeated rounds of treatment administered over several years. As use of PZQ continues, continued selection for worms with diminished susceptibility is possible, and the probability of emergence of resistance will increase as large reservoirs of untreated worms diminish. The potential for rapid emergence of resistance should be an important consideration of treatment programs.
C1 [Melman, Sandra D.; Steinauer, Michelle L.; Cunningham, Charles; Wynn, Nirvana Barker; Loker, Eric S.] Univ New Mexico, Dept Biol, Ctr Evolutionary & Theoret Immunol, Albuquerque, NM 87131 USA.
[Kubatko, Laura S.] Ohio State Univ, Dept Stat, Columbus, OH 43210 USA.
[Kubatko, Laura S.] Ohio State Univ, Dept Ecol Evolut & Organismal Biol, Columbus, OH 43210 USA.
[Mwangi, Ibrahim N.; Mutuku, Martin W.; Mkoji, Gerald M.] Kenya Govt Med Res Ctr, Ctr Biotechnol Res & Dev, Nairobi, Kenya.
[Karanja, Diana M. S.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya.
[Colley, Daniel G.; Black, Carla L.] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 USA.
[Colley, Daniel G.; Black, Carla L.] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA.
[Secor, William Evan] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA.
RP Melman, SD (reprint author), Univ New Mexico, Dept Biol, Ctr Evolutionary & Theoret Immunol, Albuquerque, NM 87131 USA.
EM michelle.steinauer@oregonstate.edu
RI Kubatko, Laura/A-7834-2008
OI Kubatko, Laura/0000-0002-5215-7144
FU National Institutes of Health [R01AI044913, R01AI053695]
FX National Institutes of Health grants R01AI044913 and R01AI053695
supported this study. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 43
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U1 1
U2 24
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD AUG
PY 2009
VL 3
IS 8
AR e504
DI 10.1371/journal.pntd.0000504
PG 10
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 486TL
UT WOS:000269220900010
PM 19688043
ER
PT J
AU Won, KY
de Rochars, MB
Kyelem, D
Streit, TG
Lammie, PJ
AF Won, Kimberly Y.
de Rochars, Madsen Beau
Kyelem, Dominique
Streit, Thomas G.
Lammie, Patrick J.
TI Assessing the Impact of a Missed Mass Drug Administration in Haiti
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Editorial Material
ID ELIMINATE LYMPHATIC FILARIASIS; WUCHERERIA-BANCROFTI; PROGRAMS; LEOGANE;
PERSPECTIVE; PREVALENCE; STRATEGIES; RESISTANCE
C1 [Won, Kimberly Y.; Lammie, Patrick J.] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30333 USA.
[de Rochars, Madsen Beau] Hop Ste Croix, Leogane, Haiti.
[Kyelem, Dominique] Emory Univ, Decatur, GA USA.
[Streit, Thomas G.] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA.
RP Won, KY (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA 30333 USA.
EM pjl1@cdc.gov
NR 14
TC 10
Z9 10
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD AUG
PY 2009
VL 3
IS 8
AR e443
DI 10.1371/journal.pntd.0000443
PG 3
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 486TL
UT WOS:000269220900002
PM 19707279
ER
PT J
AU Parra, DC
Lobelo, F
Gomez, LF
Rutt, C
Schmid, T
Brownson, RC
Pratt, M
AF Parra, Diana C.
Lobelo, Felipe
Fernando Gomez, Luis
Rutt, Candace
Schmid, Thomas
Brownson, Ross C.
Pratt, Michael
TI Household motor vehicle use and weight status among Colombian adults:
Are we driving our way towards obesity?
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Obesity; Overweight; Automobile; Nutritional transition; Latin America
ID CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; ASSOCIATION; TELEVISION;
RISK; ENVIRONMENT; DEFINITION; OVERWEIGHT; NUTRITION; TIME
AB Objective. To determine the associations between household motor vehicle ownership and weight status among Colombian adults.
Methods. Secondary analysis of data from the 2005 Demographic and HealthSurvey of Colombia. Height, weight and waist circumference were objectively measured in 49,079 adults, ages 18 to 64 that resided in urban settings. Abdominal obesity was defined as a waist circumference >80 cm in women and >90 cm in men.
Results. Prevalence was 19.9% for motor vehicle ownership in household, 33.1% for BMI between 25 and 29.9 kg/m(2), 14.4% for BMI>30 kg/m(2), and 46% for abdominal obesity. Males reporting any household motor vehicle ownership were more likely to be overweight or obese, and to have abdominal obesity (p for gender*exposure variables interaction=<0.001).
Conclusions. Household motor vehicle ownership is associated with overweight, obesity, and abdominal obesity among Colombian men but not women. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Lobelo, Felipe; Brownson, Ross C.] Washington Univ, Sch Med, Dept Surg, George Warren Brown Sch Social Work,Prevent Res C, St Louis, MO 63110 USA.
[Parra, Diana C.; Brownson, Ross C.] Washington Univ, Sch Med, Siteman Canc Ctr, St Louis, MO 63110 USA.
[Parra, Diana C.; Fernando Gomez, Luis] Fdn FES SOCIAL, Div Salud, Bogota, Colombia.
[Lobelo, Felipe] Ctr Dis Control & Prevent, Off Workforce & Career Dev, Atlanta, GA 30341 USA.
[Lobelo, Felipe; Rutt, Candace; Schmid, Thomas; Pratt, Michael] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Phys Act & Hlth Branch, Atlanta, GA 30341 USA.
RP Parra, DC (reprint author), Washington Univ, Sch Med, Dept Surg, George Warren Brown Sch Social Work,Prevent Res C, 660 S Euclid,Campus Box 8109, St Louis, MO 63110 USA.
EM dparra@gwbmail.wustl.edu
RI lobelo, felipe/B-9148-2013; Parra, Diana/B-7761-2015;
OI Parra, Diana/0000-0002-9797-6231; Lobelo, Felipe/0000-0003-4185-7193
FU National Demographics and Health Survey; Family Welfare Colombian
Institute; U.S. Agency for International Development (USAID); Colombian
Minister for Social Protection; United Nations Population Fund (UNFPA)
FX The authors would like to acknowledge Elkin Martinez for his significant
contributions to the statistical analysis and conceptual frameworks in
earlier drafts of this manuscript. The National Demographics and Health
Survey from Colombia - 2005 was carried out with support from the Family
Welfare Colombian Institute, the U.S. Agency for International
Development (USAID), Colombian Minister for Social Protection, and the
United Nations Population Fund (UNFPA).
NR 27
TC 12
Z9 13
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
J9 PREV MED
JI Prev. Med.
PD AUG-SEP
PY 2009
VL 49
IS 2-3
BP 179
EP 183
DI 10.1016/j.ypmed.2009.07.010
PG 5
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 503TF
UT WOS:000270562200020
PM 19632267
ER
PT J
AU Carlson, SA
Maynard, LM
Fulton, JE
Hootman, JM
Yoon, PW
AF Carlson, Susan A.
Maynard, L. Michele
Fulton, Janet E.
Hootman, Jennifer M.
Yoon, Paula W.
TI Physical activity advice to manage chronic conditions for adults with
arthritis or hypertension, 2007
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Exercise; Counseling; Adults; Behavioral Risk Factor Surveillance System
ID RECOMMENDATIONS; PREVENTION; EXERCISE; RISK
AB Objective. To describe the prevalence and characteristics of persons with arthritis or hypertension who received advice from their health-care professional to manage their condition.
Methods. Data from 9 states were obtained from the 2007 Behavioral Risk Factor Surveillance System. Two modules (Arthritis Management and Actions to Control High Blood Pressure) were analyzed (sample sizes: arthritis 29,698, hypertension 29.783).
Results. Fifty-five percent of persons with arthritis and 75.8% of persons with hypertension reported that their health-care professional ever suggested physical activity or exercise to help manage their condition. Correlates for being less likely to receive advice were lower levels of education, longer time since last routine doctor visit, being physically inactive, and having lower body mass index. Among inactive, normal weight persons, 43.0% (95% CI: 38.7, 47.4) with arthritis and 50.0% (95% CI: 44.4, 55.6) with hypertension reported receiving advice; among inactive, obese patients, 59.1% (95% CI: 55.8, 62.3) with arthritis and 74.0% (95% CI: 70.5, 77.3) with hypertension reported receiving advice.
Conclusions. Findings suggest that health-care professionals may base physical activity counseling more on body mass index than a patient's activity level. To manage chronic health conditions, health-care professionals should assess patient's physical activity and offer all patients appropriate counseling. Published by Elsevier Inc.
C1 [Carlson, Susan A.; Maynard, L. Michele; Fulton, Janet E.; Hootman, Jennifer M.; Yoon, Paula W.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30345 USA.
RP Carlson, SA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop K-46, Atlanta, GA 30345 USA.
EM scarlson1@cdc.gov
NR 11
TC 8
Z9 8
U1 2
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
J9 PREV MED
JI Prev. Med.
PD AUG-SEP
PY 2009
VL 49
IS 2-3
BP 209
EP 212
DI 10.1016/j.ypmed.2009.06.017
PG 4
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 503TF
UT WOS:000270562200026
PM 19573554
ER
PT J
AU Khader, A
Shaheen, Y
Turki, Y
el Awa, F
Fouad, H
Warren, CW
Jones, NR
Lea, V
Lee, J
AF Khader, Ali
Shaheen, Youssef
Turki, Yassir
el Awa, Fatimah
Fouad, Heba
Warren, Charles W.
Jones, Nathan R.
Lea, Veronica
Lee, Juliette
TI Tobacco use among Palestine refugee students (UNRWA) aged 13-15
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Tobacco use; Youth; Refugee population
ID RISK BEHAVIOR; SMOKING; ACCULTURATION; ADOLESCENTS
AB Objective. The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) has made tobacco use prevention a primary health issue. UNRWA provides education, health, relief and social services in five fields of operation: Jordan, Lebanon. Syria, Gaza Strip and the West Bank. The purpose of this paper is to compare tobacco use among Palestine refugee students and students in the general population of the five fields of operation.
Methods. Global Youth Tobacco Survey (GYTS) data were collected from representative samples of students in UNRWA schools in each of the five fields of operation in 2008. For comparison, previous data are included from GYTS conducted in Gaza Strip, Lebanon, and the West Bank (2005) and in Jordan and Syria (2007). Data are presented for three groups of students: refugees attending schools within and outside the camps and non-refugee students in the general population.
Results. In each of the five fields of operation, there was no difference in current cigarette smoking, current use of shisha, or susceptibility to initiate smoking among the three groups of students. Cigarette smoking and susceptibility was lowest in the Gaza Strip and highest in the West Bank; shisha use was lowest in the Gaza Strip but over 30% in Lebanon, Syria, and the West Bank. Exposure to secondhand smoke in public places was greater than 60% in almost all sites. Exposure to indirect advertising was almost 10%.
Conclusions. The similarity in tobacco use among the three groups of students suggests that a coordinated plan between the UNRWA and the governmental authority could be most beneficial in reducing the burden of tobacco-related morbidity and mortality. Published by Elsevier Inc.
C1 [Khader, Ali; Shaheen, Youssef; Turki, Yassir] UNRWA Headquarters, Amman, Jordan.
[el Awa, Fatimah; Fouad, Heba] World Hlth Org, Reg Off Eastern Mediterranean, Cairo, Egypt.
[Warren, Charles W.; Lea, Veronica; Lee, Juliette] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Jones, Nathan R.] Univ Wisconsin, Madison, WI USA.
RP Warren, CW (reprint author), Off Smoking & Hlth, 4770 Buford Highway,Mailstop K-50, Atlanta, GA 30341 USA.
EM wcw1@cdc.gov
NR 14
TC 7
Z9 7
U1 2
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
J9 PREV MED
JI Prev. Med.
PD AUG-SEP
PY 2009
VL 49
IS 2-3
BP 224
EP 228
DI 10.1016/j.ypmed.2009.06.001
PG 5
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 503TF
UT WOS:000270562200029
PM 19520108
ER
PT J
AU Li, CY
Ford, ES
Zhao, GX
Mokdad, AH
AF Li, Chaoyang
Ford, Earl S.
Zhao, Guixiang
Mokdad, Ali H.
TI Associations of health risk factors and chronic illnesses with life
dissatisfaction among US adults: The Behavioral Risk Factor Surveillance
System, 2006
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Life dissatisfaction; Health risk factors; Chronic illness; Subjective
well-being
ID UNITED-STATES; FOLLOW-UP; SATISFACTION; DISEASE; PREDICTORS; MORTALITY;
AGE
AB Objective. To estimate the prevalence of life dissatisfaction and assess its associations with health risk factors and chronic illnesses in adults.
Methods. Data from the Behavioral Risk Factor Surveillance System in 2006 (n = 341,140) were analyzed. Odds ratios (ORs) and their 95% confidence intervals (Cls) were estimated using logistic regression analyses.
Results. The prevalence of life dissatisfaction was estimated to be 5.0% among adults. People with one, two, and three health risk factors were, respectively, 2.2 (95% CI: 2.0-2.5), 3.7 (95% CI: 3.2-4.2), and 5.8 (95% CI: 4.6-7.4) times more likely to report life dissatisfaction than those without (P<0.0001 for linear trend). People with one, two, and three or more chronic illnesses were, respectively, 1.8 (95% CI: 1.7-2.0). 3.6 (95% CI: 3.2-4.0), and 5.0 (95% CI: 4.4-5.7) times more likely to report life dissatisfaction than those without (P<0.0001). After adjustment for self-rated health and other potential confounding variables, the associations were attenuated but remained significant for the number of health risk factors (P<0.0001 for linear trend) and the number of chronic illnesses (P<0.001).
Conclusions. Clustering of health risk factors or chronic illnesses was associated with life dissatisfaction independently of self-rated health and other established correlates. Published by Elsevier Inc.
C1 [Li, Chaoyang; Ford, Earl S.; Zhao, Guixiang] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Mokdad, Ali H.] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA.
RP Li, CY (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,MS K66, Atlanta, GA 30341 USA.
EM cli@cdc.gov
NR 29
TC 9
Z9 9
U1 2
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
J9 PREV MED
JI Prev. Med.
PD AUG-SEP
PY 2009
VL 49
IS 2-3
BP 253
EP 259
DI 10.1016/j.ypmed.2009.05.012
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 503TF
UT WOS:000270562200035
PM 19501613
ER
PT J
AU Chu, SY
Abe, K
Hall, LR
Kim, SY
Njoroge, T
Qin, C
AF Chu, Susan Y.
Abe, Karon
Hall, Laura R.
Kim, Shin Y.
Njoroge, Terry
Qin, Cheng
TI Gestational diabetes mellitus: All Asians are not alike
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Asian; Pacific Islanders; Gestational diabetes; Pregnancy; Birth
certificate
ID BODY-MASS INDEX; NEW-YORK-CITY; RISK-FACTORS; JAPANESE-AMERICANS;
VISCERAL ADIPOSITY; GLUCOSE-TOLERANCE; PREGNANT-WOMEN; UNITED-STATES;
OBESITY; PREVALENCE
AB Objective. To estimate the prevalence of gestational diabetes mellitus (GDM) prevalence estimates for subgroups of US Asian and Pacific Islander (API) women by using data from 2005 and 2006 birth certificates.
Methods. Using 2005-2006 natality files from states that implemented the revised 2003 US birth certificate, which differentiates between CDM and preexisting diabetes (2005: 12 states; 2006: 19 states), we calculated age-adjusted GDM prevalence estimates for API mothers who delivered singleton infants.
Results. Among 3,108,877 births, US APIs had a substantially higher age-adjusted prevalence of GDM (6.3%) than whites (3.8%), blacks (3.5%), or Hispanics (3.6%). Among API subgroups, age-adjusted GDM prevalence varied significantly, from 3.7% among women of Japanese descent to 8.6% among women of Asian Indian descent. Foreign-born APIs had significantly higher GDM rates than US-born APIs except among women of Japanese and Korean ancestry.
Conclusion. Overall, US API women have the highest risk for GDM among all US racial/ethnic groups. However, APIs are a heterogeneous group by genetic background, culture, and diet and other lifestyle behaviors. Our findings imply that, whenever possible, API subgroups should be evaluated separately in health research. Published by Elsevier Inc.
C1 [Chu, Susan Y.; Abe, Karon; Hall, Laura R.; Kim, Shin Y.; Njoroge, Terry; Qin, Cheng] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA.
RP Chu, SY (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Hwy,Mailstop K-23, Atlanta, GA 30341 USA.
EM syc1@cdc.gov
NR 45
TC 51
Z9 51
U1 1
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
J9 PREV MED
JI Prev. Med.
PD AUG-SEP
PY 2009
VL 49
IS 2-3
BP 265
EP 268
DI 10.1016/j.ypmed.2009.07.001
PG 4
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 503TF
UT WOS:000270562200037
PM 19596364
ER
PT J
AU Anderson, M
Elam, G
Solarin, I
Gerver, S
Fenton, K
Easterbrook, P
AF Anderson, Moji
Elam, Gillian
Solarin, Ijeoma
Gerver, Sarah
Fenton, Kevin
Easterbrook, Philippa
TI Coping With HIV: Caribbean People in the United Kingdom
SO QUALITATIVE HEALTH RESEARCH
LA English
DT Article
DE coping and adaptation; HIV/AIDS; illness and disease, responses;
interviews, semistructured; minorities
ID PSYCHOLOGICAL DISTRESS; SOCIAL SUPPORT; HEALTH INEQUALITIES;
ETHNIC-GROUPS; AFRICAN; BLACK; HIV/AIDS; INFECTION; ILLNESS; SELF
AB Although Caribbean people in the United Kingdom are increasingly being affected by HIV/AIDS, there has been no examination of how they are coping with the illness. We investigate the coping strategies of HIV-positive Caribbean people using in-depth interviews with a purposively selected group of 25 residents of South London. The main coping strategies were more cognitive than behavioral: restricted disclosure, submersion, faith, and positive reappraisal. These strategies were intertwined in complex ways, and most were rooted in contextual factors, particularly cultural ones. Themes of loss, silence, and reinvention suffused respondents' narratives. Interventions should consider the high degree of stigmatization of HIV/AIDS in the Caribbean community, reluctance to disclose, the likelihood of an initial severe reaction to diagnosis, and external stressors. HIV-positive Caribbean people who are coping well could serve as mentors and role models for poor copers and newly diagnosed patients; establishing Caribbean-specific support groups might also assist coping.
C1 [Anderson, Moji] Univ W Indies, Dept Sociol Psychol & Social Work, Kingston 7, Jamaica.
[Elam, Gillian] UCL, Ctr Sexual Hlth & HIV Res, London, England.
[Solarin, Ijeoma; Gerver, Sarah] Kings Coll London, Guys Kings & St Thomas Sch Med, Acad Dept HIV GUM, London WC2R 2LS, England.
[Fenton, Kevin] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
[Easterbrook, Philippa] Kings Coll London, Guys Kings & St Thomas Sch Med, Dept HIV GUM, London WC2R 2LS, England.
RP Anderson, M (reprint author), Univ W Indies, Dept Sociol Psychol & Social Work, Kingston 7, Jamaica.
FU Medical Research Council [, G0200585]
NR 72
TC 10
Z9 10
U1 3
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1049-7323
J9 QUAL HEALTH RES
JI Qual. Health Res.
PD AUG
PY 2009
VL 19
IS 8
BP 1060
EP 1075
DI 10.1177/1049732309341191
PG 16
WC Information Science & Library Science; Social Sciences,
Interdisciplinary; Social Sciences, Biomedical
SC Information Science & Library Science; Social Sciences - Other Topics;
Biomedical Social Sciences
GA 475WT
UT WOS:000268396500004
PM 19638600
ER
PT J
AU Pohl, HR
Mumtaz, MM
Scinicariello, F
Hansen, H
AF Pohl, Hana R.
Mumtaz, Moiz M.
Scinicariello, Franco
Hansen, Hugh
TI Binary weight-of-evidence evaluations of chemical interactions-15 years
of experience
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Risk assessment; Chemical mixtures; Interactions; Additivity; Synergism;
Antagonism
ID BREAST-CANCER RISK; PUBLIC-HEALTH PRACTICE; POLYCHLORINATED-BIPHENYLS;
CYTOCHROME-P450 1A1; CONCURRENT EXPOSURE; MALE-RATS; LEAD; MIXTURES;
TOXICITY; CADMIUM
AB The paper reflects on the last 15 years of experience in the field of mixtures risk assessment. It summarizes results found in various documents developed by the Agency for Toxic Substances and Disease Registry (ATSDR) of the weight-of-evidence (WOE) approach applied to 380 binary combinations of chemicals. Of these evaluations, 156 assessments indicated possible additivity of effects [=], 76 indicated synergism (greater-than-additive effects [>]), and 57 indicated antagonism (less-than-additive effects [<]). However, 91 combinations lacked the minimum information needed for making any assessments and, hence, were undetermined.
The paper provides examples of the rationale behind some of the WOE decisions and discusses the importance of expert judgments in risk assessment evaluations. Examples are given regarding the importance of human variability in mixtures' ability to affect human health and regarding the dose versus effect relationships. Published by Elsevier Inc.
C1 [Pohl, Hana R.; Mumtaz, Moiz M.; Scinicariello, Franco; Hansen, Hugh] Agcy Tox Subst & Dis Registry, US Dept Hlth & Human Serv, Div Toxicol & Environm Med, Atlanta, GA 30333 USA.
RP Pohl, HR (reprint author), Agcy Tox Subst & Dis Registry, US Dept Hlth & Human Serv, Div Toxicol & Environm Med, 1600 Clifton Rd,F-32, Atlanta, GA 30333 USA.
EM hpohl@cdc.gov
NR 69
TC 7
Z9 8
U1 1
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD AUG
PY 2009
VL 54
IS 3
BP 264
EP 271
DI 10.1016/j.yrtph.2009.05.003
PG 8
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA 476TX
UT WOS:000268469900009
PM 19445993
ER
PT J
AU King, LJ
AF King, L. J.
TI One world of veterinary medicine
SO REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES
LA English
DT Article
DE One World; Veterinary education; Veterinary medicine
AB The veterinary profession finds itself in the midst of a new world order. Today veterinarians are part of a world that is exquisitely interconnected culturally, economically, socially, and professionally. As a consequence, societal needs and expectations of the profession are more demanding, critical and far-reaching.
Veterinarians must play important roles in five intersecting domains of work: public health, bio-medical research, global food safety and security, ecosystem health and the more traditional role of caring for animals. To be successful in this broad and complex range of services and activities, veterinarians must possess an expanded knowledge base, acquire new skills, and develop a new mindset that will ensure their success and excellence in all these domains.
The veterinary profession is becoming more fragmented and specialised, and it needs to be brought back together by a single sphere of knowledge or discipline that can serve as an intellectual foundation. The concept of One World of Veterinary Medicine can do just that. With this mindset veterinarians will become better connected to the world around and gain new public recognition and esteem.
To achieve this, a special commitment by academic veterinary medicine is, of course, essential. Veterinary schools must lead an educational transformation that reaffirms the social contract of veterinarians and works to align diverse sectors, build a global community, find a common purpose and expand the 21st Century veterinary portfolio of services, activities, and new possibilities.
C1 Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA.
RP King, LJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Zoonot Vector Borne & Enter Dis, 1600 Clifton Rd, Atlanta, GA 30333 USA.
NR 10
TC 7
Z9 7
U1 0
U2 5
PU OFFICE INT EPIZOOTIES
PI PARIS
PA 12 RUE DE PRONY, 75017 PARIS, FRANCE
SN 0253-1933
J9 REV SCI TECH OIE
JI Rev. Sci. Tech. Off. Int. Epizoot.
PD AUG
PY 2009
VL 28
IS 2
BP 463
EP 467
PG 5
WC Veterinary Sciences
SC Veterinary Sciences
GA 540YI
UT WOS:000273376800003
PM 20128453
ER
PT J
AU Chomel, BB
Marano, N
AF Chomel, B. B.
Marano, N.
TI Essential veterinary education in emerging infections, modes of
introduction of exotic animals, zoonotic diseases, bioterrorism,
implications for human and animal health and disease manifestation
SO REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES
LA English
DT Article
DE Bioterrorism; Curriculum; Emerging zoonoses; Exotic companion animals;
Veterinary education
ID PUBLIC-HEALTH; UNITED-STATES; HUMAN MONKEYPOX; PHYSICIANS; ZOONOSES;
MEDICINE; ECOLOGY; RABIES; RISKS
AB A fundamental role of the veterinary profession is the protection of human health through wholesome food and control of diseases of animal origin, especially zoonoses. Therefore, training of veterinary students worldwide needs to face the new challenges posed by emerging infections, both from wildlife and domestic animals, as well as risks from bio/agroterrorism. New courses emphasising recognition, response, recovery and prevention must be developed to respond to natural or intentionally induced emerging diseases and zoonoses. Training programmes in applied epidemiology, zoonoses and foreign animal diseases are crucial for the development of a strong workforce to deal with microbial threats. Students should learn the reporting pathways for reportable diseases in their countries or states. Knowledge of the principles of ecology and ecosystems should be acquired during pre-veterinary studies. Elective classes on wildlife diseases, emphasising wildlife zoonotic diseases, should be offered during the veterinary curriculum, as well as a course on risk communication, since veterinarians are frequently in the position of having to convey complex information under adverse circumstances.
C1 [Chomel, B. B.] Univ Calif Davis, Sch Vet Med, Dept Populat Hlth & Reprod, Davis, CA 95616 USA.
[Marano, N.] Ctr Dis Control & Prevent, Geog Med & Hlth Promot Branch, Div Global Migrat & Quarantine, NCPDCID,OIE Collaborating Ctr Emerging & Reemergi, Atlanta, GA 30333 USA.
RP Chomel, BB (reprint author), Univ Calif Davis, Sch Vet Med, Dept Populat Hlth & Reprod, Davis, CA 95616 USA.
NR 27
TC 3
Z9 3
U1 2
U2 11
PU OFFICE INT EPIZOOTIES
PI PARIS
PA 12 RUE DE PRONY, 75017 PARIS, FRANCE
SN 0253-1933
J9 REV SCI TECH OIE
JI Rev. Sci. Tech. Off. Int. Epizoot.
PD AUG
PY 2009
VL 28
IS 2
BP 559
EP 565
PG 7
WC Veterinary Sciences
SC Veterinary Sciences
GA 540YI
UT WOS:000273376800014
PM 20128464
ER
EF