FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Spesock, A
Malur, M
Hossain, MJ
Chen, LM
Njaa, BL
Davis, CT
Lipatov, AS
York, IA
Krug, RM
Donis, RO
AF Spesock, April
Malur, Meghana
Hossain, M. Jaber
Chen, Li-Mei
Njaa, Bradley L.
Davis, Charles T.
Lipatov, Aleksandr S.
York, Ian A.
Krug, Robert M.
Donis, Ruben O.
TI The Virulence of 1997 H5N1 Influenza Viruses in the Mouse Model Is
Increased by Correcting a Defect in Their NS1 Proteins
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; HORMONE DEFICIENCY SYNDROME;
NEUROVIRULENCE SAFETY TEST; MUMPS-VIRUS; PARAINFLUENZA VIRUS;
HEMAGGLUTININ-NEURAMINIDASE; POLYMERASE PROTEINS; MATRIX PROTEIN; RABIES
VIRUS; RNA VIRUSES
AB The NS1 protein of human influenza A viruses binds the 30-kDa subunit of the cleavage and polyadenylation specificity factor (CPSF30), a protein required for 3' end processing of cellular pre-mRNAs, thereby inhibiting production of beta interferon (IFN-beta) mRNA. The NS1 proteins of pathogenic 1997 H5N1 viruses contain the CPSF30-binding site but lack the consensus amino acids at positions 103 and 106, F and M, respectively, that are required for the stabilization of CPSF30 binding, resulting in nonoptimal CPSF30 binding in infected cells. Here we have demonstrated that strengthening CPSF30 binding, by changing positions 103 and 106 in the 1997 H5N1 NS1 protein to the consensus amino acids, results in a remarkable 300-fold increase in the lethality of the virus in mice. Unexpectedly, this increase in virulence is not associated with increased lung pathology but rather is characterized by faster systemic spread of the virus, particularly to the brain, where increased replication and severe pathology occur. This increased spread is associated with increased cytokine and chemokine levels in extrapulmonary tissues. We conclude that strengthening CPSF30 binding by the NS1 protein of 1997 H5N1 viruses enhances virulence in mice by increasing the systemic spread of the virus from the lungs, particularly to the brain.
C1 [Spesock, April; Hossain, M. Jaber; Chen, Li-Mei; Davis, Charles T.; Lipatov, Aleksandr S.; York, Ian A.; Donis, Ruben O.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA.
[Krug, Robert M.] Univ Texas Austin, Dept Mol Genet & Microbiol, Inst Cellular & Mol Biol, Sect Mol Genet & Microbiol, Austin, TX 78712 USA.
[Njaa, Bradley L.] Oklahoma State Univ, Ctr Vet Hlth Sci, Dept Pathobiol, Stillwater, OK 74078 USA.
[Spesock, April; Hossain, M. Jaber] Battelle Mem Inst, Atlanta, GA 30333 USA.
RP Donis, RO (reprint author), Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd NE,MD G16, Atlanta, GA 30333 USA.
EM rkrug@mail.utexas.edu; rvd6@cdc.gov
OI York, Ian/0000-0002-3478-3344
FU Oak Ridge Institute for Science and Education
FX Salary support for C.X.Z., L.N., and K. W. was provided by the Oak Ridge
Institute for Science and Education through an interagency agreement
between the U.S. Department of Energy and the U.S. Food and Drug
Administration.
NR 48
TC 36
Z9 37
U1 1
U2 9
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JUL
PY 2011
VL 85
IS 14
BP 7048
EP 7069
DI 10.1128/JVI.00417-11
PG 22
WC Virology
SC Virology
GA 781LA
UT WOS:000291932400022
PM 21593152
ER
PT J
AU Holtz, TH
Kabera, G
Mthiyane, T
Zingoni, T
Nadesan, S
Ross, D
Allen, J
Chideya, S
Sunpath, H
Rustomjee, R
AF Holtz, Timothy H.
Kabera, Gaetan
Mthiyane, Thuli
Zingoni, Tainos
Nadesan, Sidhambaram
Ross, Douglas
Allen, Jennifer
Chideya, Sekai
Sunpath, Henry
Rustomjee, Roxana
TI Use of a WHO-recommended algorithm to reduce mortality in seriously ill
patients with HIV infection and smear-negative pulmonary tuberculosis in
South Africa: an observational cohort study
SO LANCET INFECTIOUS DISEASES
LA English
DT Article
ID DIAGNOSIS; AREA; PREVALENCE; PEOPLE; ADULTS; ERA
AB Background In 2007, WHO released revised recommendations and an algorithm for the diagnosis and treatment of smear-negative pulmonary tuberculosis in seriously ill people living with HIV/AIDS. We aimed to assess the effect of the recommendations on clinical outcome in patients in South Africa.
Methods We enrolled seriously ill patients (aged >= 15 years) with HIV infection and suspected smear-negative pulmonary tuberculosis from three hospitals in KwaZulu.Natal, South Africa. Patients were consecutively enrolled into two cohorts: the first cohort was managed according to standard practice, and the second according to the WHO-recommended algorithm. The primary endpoints were rates of continued stay in hospital at 7 days after admission and survival at 8 weeks after admission.
Findings 338 patients were enrolled in the standard practice cohort between August, 2008, and February, 2009, and 187 were enrolled in the algorithm cohort between March, 2009, and December, 2009. 7 days after hospital admission, 27% (n=50) of patients in the algorithm cohort were still in hospital, compared with 38% (n=130) in the standard practice cohort (rate ratio 0.70, 95% CI 0.53-0.91; p=0.009). 8 weeks after admission, 83% (n=156) of patients in the algorithm cohort were alive, compared with 68% (n=230) in the standard practice cohort (1.23, 1.11-1.35; p=0.0001), with effect modified by hospital location.
Interpretation In seriously ill patients with HIV infection and suspected smear-negative pulmonary tuberculosis, early antituberculosis treatment according to the WHO algorithm could significantly reduce mortality in South Africa.
C1 [Holtz, Timothy H.] US Ctr Dis Control & Prevent, Div HIVAIDS Prevent, Atlanta, GA USA.
[Chideya, Sekai] US Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA USA.
[Kabera, Gaetan; Mthiyane, Thuli; Allen, Jennifer; Rustomjee, Roxana] MRC, Durban, South Africa.
[Zingoni, Tainos; Ross, Douglas] St Marys Hosp, Mariannhill, South Africa.
[Nadesan, Sidhambaram; Sunpath, Henry] McCord Hosp, Durban, South Africa.
RP Holtz, TH (reprint author), Minist Publ Hlth, US Ctr Dis Control & Prevent, SE Asia Reg Off, DDC 7 Bldg,4th Floor,Soi 4, Nonthaburi 11000, Thailand.
EM tholtz@th.cdc.gov
FU US President's Emergency Plan for AIDS Relief
FX US President's Emergency Plan for AIDS Relief.
NR 34
TC 27
Z9 27
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1473-3099
J9 LANCET INFECT DIS
JI Lancet Infect. Dis.
PD JUL
PY 2011
VL 11
IS 7
BP 533
EP 540
DI 10.1016/S1473-3099(11)70057-3
PG 8
WC Infectious Diseases
SC Infectious Diseases
GA 783ZT
UT WOS:000292124100021
PM 21514234
ER
PT J
AU Lee, JWY
Berkowitz, Z
Saraiya, M
AF Lee, Jennifer Wai-Yin
Berkowitz, Zahava
Saraiya, Mona
TI Low-Risk Human Papillomavirus Testing and Other Nonrecommended Human
Papillomavirus Testing Practices Among US Health Care Providers
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
ID CERVICAL-CANCER; NATURAL-HISTORY; UNITED-STATES; YOUNG-WOMEN; INFECTION;
OUTCOMES; IMPACT; METAANALYSIS; NEOPLASIA; CYTOLOGY
AB OBJECTIVE: To assess self-reported human papillomavirus (HPV) DNA testing practices by health care providers and clinics, including nonrecommended practices such as low-risk HPV testing, HPV cotesting in women younger than age 30 years, and HPV reflex testing for high-grade abnormal Pap test results.
METHODS: We analyzed responses to a cross-sectional survey of a nationally representative sample of Papanicolaou test providers administered in conjunction with the 2006 National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey. Data analysis was performed on responses from 376 office-based health care providers and 216 outpatient clinics.
RESULTS: Overall, 75.5% (95% confidence interval [CI] 68.7-81.2%) of health care providers and 77.2% (95% CI 60.3-88.3%) of clinics reported ever using the HPV DNA test. Of health care providers who used HPV testing, 28.5% (95% CI 21.6-36.6%) used both high-risk and low-risk HPV tests. Most health care providers (59.6%, 95% CI 48.5-69.7%) and clinics (66.0%, 95% CI 48.0-80.3%) used HPV cotesting in women younger than age 30 years. A high percentage of health care providers and clinics performed reflex HPV testing after Pap test results of atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions (71.4%, 95% CI 63.5-78.3% and 62.8%, 95% CI 49.0-74.9%, respectively) and high-grade squamous intraepithelial lesions (50.7%, 95% CI 42.4-58.9% and 49.0%, 95% CI 33.1-65.2%, respectively), results for which HPV testing is not recommended.
CONCLUSION: Many health care providers reported inappropriate uses of HPV testing, which may lead to unnecessary follow-up and increased medical costs without added benefits. Interventions such as eliminating the low-risk HPV test from the U. S. market and educating health care providers and patients on appropriate indications for HPV testing are needed to discourage health care providers from such practices. (Obstet Gynecol 2011;118:4-13) DOI: 10.1097/AOG.0b013e3182210034
C1 [Saraiya, Mona] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30341 USA.
Sci Educ & Profess Dev Program Off, CDC Experience Appl Epidemiol, Atlanta, GA USA.
Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
RP Saraiya, M (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Highway,Mailstop K-55, Atlanta, GA 30341 USA.
EM MSaraiya@cdc.gov
FU External Medical Affairs, Pfizer Inc.
FX Jennifer Wai-Yin Lee completed this project during a 1-year fellowship
with The CDC Experience, a public/private partnership supported by a
grant to the CDC foundation from the External Medical Affairs, Pfizer
Inc.
NR 29
TC 23
Z9 23
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD JUL
PY 2011
VL 118
IS 1
BP 4
EP 13
DI 10.1097/AOG.0b013e3182210034
PG 10
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 780SY
UT WOS:000291880600002
PM 21691157
ER
PT J
AU MacKay, AP
Berg, CJ
Liu, X
Duran, C
Hoyert, DL
AF MacKay, Andrea P.
Berg, Cynthia J.
Liu, Xiang
Duran, Catherine
Hoyert, Donna L.
TI Changes in Pregnancy Mortality Ascertainment United States, 1999-2005
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
ID MATERNAL MORTALITY; SURVEILLANCE
AB OBJECTIVE: To estimate mortality ratios for all reported pregnancy deaths in the United States, 1999-2005, and to estimate the effect of the 1999 implementation of International Classification of Diseases, Tenth Revision (ICD-10) and adoption of the U.S. Standard Certificate of Death, 2003 Revision, on the ascertainment of deaths resulting from pregnancy.
METHODS: We combined information on pregnancy deaths from the National Vital Statistics System and the Pregnancy Mortality Surveillance System to estimate maternal (during or within 42 days of pregnancy) and pregnancy-related (during or within 1 year of pregnancy) mortality ratios (deaths per 100,000 live births). Data for 1995-1997, 1999-2002, and 2003-2005 were compared in order to estimate the effects of the change to ICD-10 and the inclusion of a pregnancy checkbox on the death certificate.
RESULTS: The maternal mortality ratio increased significantly from 11.6 in 1995-1997 to 13.1 for 1999-2002 and 15.3 in 2003-2005; the pregnancy-related mortality ratio increased significantly from 12.6 to 14.7 and 18.1 during the same periods. Vital statistics identified significantly more indirect maternal deaths in 2002-2005 than in 1999-2002. Between 2002 and 2005, mortality ratios increased significantly among 19 states using the revised death certificate with a pregnancy checkbox; ratios did not increase in states without a checkbox.
CONCLUSION: Changes in ICD-10 and the 2003 revision of the death certificate increased ascertainment of pregnancy deaths. The changes may also have contributed to misclassification of some deaths as maternal in the vital statistics system. Combining data from both systems estimates higher pregnancy mortality ratios than from either system individually. (Obstet Gynecol 2011;118:104-10) DOI: 10.1097/AOG.0b013e31821fd49d
C1 Ctr Dis Control & Prevent, Off Anal & Epidemiol, Natl Ctr Hlth Stat, Hyattsville, MD USA.
Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA.
Ctr Dis Control & Prevent, Div Vital Stat, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
RP MacKay, AP (reprint author), Ctr Dis Control & Prevent CDC, Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 6121, Hyattsville, MD 20782 USA.
EM anm3@cdc.gov
NR 16
TC 16
Z9 17
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD JUL
PY 2011
VL 118
IS 1
BP 104
EP 110
DI 10.1097/AOG.0b013e31821fd49d
PG 7
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 780SY
UT WOS:000291880600015
PM 21691169
ER
PT J
AU Dawood, FS
Kamimoto, L
D'Mello, TA
Reingold, A
Gershman, K
Meek, J
Arnold, KE
Farley, M
Ryan, P
Lynfield, R
Morin, C
Baumbach, J
Zansky, S
Bennett, N
Thomas, A
Schaffner, W
Kirschke, D
Finelli, L
AF Dawood, Fatimah S.
Kamimoto, Laurie
D'Mello, Tiffany A.
Reingold, Arthur
Gershman, Ken
Meek, James
Arnold, Kathryn E.
Farley, Monica
Ryan, Patricia
Lynfield, Ruth
Morin, Craig
Baumbach, Joan
Zansky, Shelley
Bennett, Nancy
Thomas, Ann
Schaffner, William
Kirschke, David
Finelli, Lyn
CA Emerging Infect Program Network
TI Children With Asthma Hospitalized With Seasonal or Pandemic Influenza,
2003-2009
SO PEDIATRICS
LA English
DT Article
DE influenza; asthma; pandemic
ID IMMUNIZATION PRACTICES ACIP; UNITED-STATES; VACCINES RECOMMENDATIONS;
ADVISORY-COMMITTEE; H1N1 INFLUENZA; VACCINATION; PREVENTION; BURDEN
AB OBJECTIVE: To describe the characteristics and clinical courses of asthmatic children hospitalized with seasonal or 2009 pandemic H1N1 influenza and compare complications by influenza type.
METHODS: During the 2003-2009 influenza seasons and the 2009 pandemic, we conducted surveillance of 5.3 million children aged 17 years or younger for hospitalization with laboratory-confirmed influenza and identified those with asthma (defined as those aged 2-17 years with a history of asthma in their medical record or a discharge code for acute asthma exacerbation or status asthmaticus). We collected data from medical records on medical history and clinical course; data on asthma severity and control were not routinely collected.
RESULTS: During the 2003-2009 influenza seasons, 701 (32%) of 2165 children hospitalized with influenza had asthma; during the 2009 pandemic, 733 (44%) of 1660 children had asthma. The median age of the asthmatic children was 7 years, and 73% had no additional medical conditions. Compared with asthmatic children with seasonal influenza, a higher proportion with 2009 pandemic H1N1 influenza required intensive care (16% vs 22%; P = .01) and were diagnosed with pneumonia (40% vs 46%; P = .04), whereas equal proportions had respiratory failure (5% vs 5%; P = .8) and died (1% vs 1%; P = .4). More asthmatic children with influenza A (seasonal or pandemic) had diagnoses of asthma exacerbations compared with those with influenza B (51% vs 29%; P < .01).
CONCLUSIONS: The majority of asthmatic children hospitalized with influenza have no additional medical conditions. Complications such as pneumonia and need for intensive care occur in a substantial proportion, highlighting the importance of influenza prevention through vaccination among asthmatic children. Pediatrics 2011;128:e27-e32
C1 [Dawood, Fatimah S.; Kamimoto, Laurie; D'Mello, Tiffany A.; Finelli, Lyn] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA.
[Reingold, Arthur] California Emerging Infect Program, Oakland, CA USA.
[Gershman, Ken] Colorado Dept Publ Hlth & Environm, Denver, CO USA.
[Meek, James] Yale Univ, Connecticut Emerging Infect Program, New Haven, CT USA.
[Arnold, Kathryn E.] Georgia Dept Community Hlth, Div Publ Hlth, Atlanta, GA USA.
[Farley, Monica] Emory Univ, Sch Med, Atlanta, GA USA.
[Farley, Monica] Atlanta Vet Affairs Med Ctr, Atlanta, GA USA.
[Ryan, Patricia] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA.
[Lynfield, Ruth; Morin, Craig] Minnesota Dept Hlth, St Paul, MN USA.
[Baumbach, Joan] New Mexico Dept Hlth, Santa Fe, NM USA.
[Zansky, Shelley] New York State Dept Hlth, Emerging Infect Program, Albany, NY USA.
[Bennett, Nancy] Univ Rochester, Sch Med, Dept Med, Rochester, NY USA.
[Bennett, Nancy] Dent & Monroe Cty Dept Hlth, Rochester, NY USA.
[Thomas, Ann] Oregon Publ Hlth Div, Portland, OR USA.
[Schaffner, William; Kirschke, David] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA.
RP Dawood, FS (reprint author), Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd,MS A-32, Atlanta, GA 30333 USA.
EM fdawood@cdc.gov
NR 15
TC 23
Z9 26
U1 0
U2 1
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD JUL
PY 2011
VL 128
IS 1
BP E27
EP E32
DI 10.1542/peds.2010-3343
PG 6
WC Pediatrics
SC Pediatrics
GA 786IV
UT WOS:000292299500004
PM 21646257
ER
PT J
AU Lindley, MC
Smith, PJ
Rodewald, LE
AF Lindley, Megan C.
Smith, Philip J.
Rodewald, Lance E.
TI Vaccination Coverage Among U.S. Adolescents Aged 13-17 Years Eligible
for the Vaccines for Children Program, 2009
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID HUMAN-PAPILLOMAVIRUS VACCINATION; IMMUNIZATION PRACTICES ACIP;
UNITED-STATES; ADVISORY-COMMITTEE; CARE; RECOMMENDATIONS; REIMBURSEMENT;
PREVENTION; SERVICES; DELIVERY
AB Objectives. We compared (1) characteristics of adolescents who are and are not entitled to receive free vaccines from the Vaccines for Children (VFC) program and (2) vaccination coverage with meningococcal conjugate (MCV4), quadrivalent human papillomavirus (HPV4), and tetanus-diphtheria-acellular pertussis (Tdap) vaccines among VFC-eligible and non-VFC-eligible adolescents.
Methods. We analyzed data from the 2009 National Immunization Survey-Teen, a nationally representative, random-digit-dialed survey of households with adolescents aged 13-17 years (n=20,066). Differences in sociodemographic characteristics and provider-reported vaccination coverage were evaluated using t-tests.
Results. Overall, 32.1% (+/- 1.2%) of adolescents were VFC-eligible. VFC-eligible adolescents were significantly less likely than non-VFC-eligible adolescents to be white and to live in suburban areas, and more likely to live in poverty and to have younger and less educated mothers. Nationally, coverage among non-VFC-eligible adolescents was 57.1% (+/- 1.5%) for >= 1 dose of Tdap, 55.4% (+/- 1.5%) for >= 1 dose of MCV4, and 43.2% (+/- 2.2%) for >= 1 dose of HPV4. Coverage among VFC-eligible adolescents was 52.5% (+/- 2.4%) for >= 1 dose of Tdap, 50.1% (+/- 2.4%) for >= 1 dose of MCV4, and 46.6% (+/- 3.5%) for >= 1 dose of HPV4. Only 27.5% (+/- 1.8%) of non-VFC-eligible adolescents and 25.0% (+/- 2.9%) of VFC-eligible adolescents received >= 3 doses of HPV4. Vaccination coverage was significantly higher among non-VFC-eligible adolescents for Tdap and MCV4, but not for one-dose or three-dose HPV4.
Conclusions. Coverage with some recommended vaccines is lower among VFC-eligible adolescents compared with non-VFC-eligible adolescents. Continued monitoring of adolescent vaccination rates, particularly among VFC-eligible populations, is needed to ensure that all adolescents receive all routinely recommended vaccines.
C1 [Lindley, Megan C.; Smith, Philip J.; Rodewald, Lance E.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Lindley, MC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS E-52, Atlanta, GA 30333 USA.
EM MLindley@cdc.gov
NR 36
TC 20
Z9 20
U1 1
U2 2
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD JUL-AUG
PY 2011
VL 126
SU 2
BP 124
EP 134
PG 11
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 777ZT
UT WOS:000291665800014
PM 21815303
ER
PT J
AU Klevens, RM
Kruszon-Moran, D
Wasley, A
Gallagher, K
McQuillan, GM
Kuhnert, W
Teshale, EH
Drobeniuc, J
Bell, BP
AF Klevens, R. Monina
Kruszon-Moran, Deanna
Wasley, Annemarie
Gallagher, Kathleen
McQuillan, Geraldine M.
Kuhnert, Wendi
Teshale, Eyasu H.
Drobeniuc, Jan
Bell, Beth P.
TI Seroprevalence of Hepatitis A Virus Antibodies in the US: Results from
the National Health and Nutrition Examination Survey
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID UNITED-STATES; VACCINATION COVERAGE; IMMUNIZATION; EPIDEMIOLOGY;
INFECTION
AB Objectives. We described seroprevalence of antibody to hepatitis A virus (anti-HAV) in the United States during 1999-2006 and compared it with seroprevalence before the availability of vaccine.
Methods. We analyzed data from the 1988-1994 and 1999-2006 National Health and Nutrition Examination Survey (NHANES) to obtain estimates of anti-HAV seroprevalence for the U.S. household population. We grouped region of residence based on the 1999 Advisory Committee on Immunization Practices recommendations into 17 states with any recommendation (vaccinating) and 33 states without any recommendation (non-vaccinating).
Results. During 1999-2006, the overall seroprevalence of anti-HAV was 34.9% (95% confidence interval [CI] 33.1, 36.7). During 1999-2006, U.S.-born children living in vaccinating states (33.8%, 95% CI 26.2, 42.2) had a higher seroprevalence than children in non-vaccinating states (11.0%, 95% CI 9.4, 12.8; p<0.001). Seroprevalence among children increased from 8.0% (95% Cl 6.3, 10.1) during 1988-1994 to 20.2% (95% CI 16.0, 24.8) during 1999-2006 (p<0.001). For U.S.-born children aged 6-19 years, the strongest factor associated with seroprevalence was residence in vaccinating states. Among U.S.-born adults aged >19 years, the overall age-adjusted seroprevalence of anti-HAV was 29.9% (95% CI 28.3, 31.5) during 1999-2006, which was not significantly different from the seroprevalence during 1988-1994 (32.2%, 95% CI 30.1, 34.4).
Conclusions. Increases in seroprevalence among children in vaccinating states suggest a positive effect of the 1999 vaccination recommendations.
C1 [Klevens, R. Monina; Teshale, Eyasu H.; Drobeniuc, Jan] Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
[Kruszon-Moran, Deanna; McQuillan, Geraldine M.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
[Wasley, Annemarie; Gallagher, Kathleen; Kuhnert, Wendi] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA USA.
[Bell, Beth P.] Ctr Dis Control & Prevent, Off Director, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
RP Klevens, RM (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE,MS G-37, Atlanta, GA 30333 USA.
EM rmk2@cdc.gov
NR 23
TC 18
Z9 18
U1 0
U2 3
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD JUL-AUG
PY 2011
VL 126
IS 4
BP 522
EP 532
PG 11
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 777ZS
UT WOS:000291665600008
PM 21800746
ER
PT J
AU Knoeller, GE
Mazurek, JM
Moorman, JE
AF Knoeller, Gretchen E.
Mazurek, Jacek M.
Moorman, Jeanne E.
TI Student Column WORK-RELATED ASTHMA AMONG ADULTS WITH CURRENT ASTHMA IN
33 STATES AND DC: EVIDENCE FROM THE ASTHMA CALL-BACK SURVEY, 2006-2007
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID NEW-YORK-STATE; OCCUPATIONAL ASTHMA; UNITED-STATES; HEALTH; DIAGNOSIS;
PREVALENCE; SURVEILLANCE; MANAGEMENT; MICHIGAN; QUALITY
C1 [Knoeller, Gretchen E.] NIOSH, Ctr Dis Control & Prevent, Div Resp Dis Studies, Sch Publ Hlth, Morgantown, WV 26505 USA.
[Mazurek, Jacek M.] NIOSH, CDC, Div Resp Dis Studies, Morgantown, WV USA.
[Moorman, Jeanne E.] CDC, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Atlanta, GA 30333 USA.
RP Knoeller, GE (reprint author), NIOSH, Ctr Dis Control & Prevent, Div Resp Dis Studies, Sch Publ Hlth, 1095 Willowdale Rd,MS-HG900, Morgantown, WV 26505 USA.
EM ipb8@cdc.gov
NR 53
TC 10
Z9 10
U1 0
U2 0
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD JUL-AUG
PY 2011
VL 126
IS 4
BP 603
EP 611
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 777ZS
UT WOS:000291665600018
PM 21800756
ER
PT J
AU Huang, TTK
Borowski, LA
Liu, BM
Galuska, DA
Ballard-Barbash, R
Yanovski, SZ
Olster, DH
Atienza, AA
Smith, AW
AF Huang, Terry T-K
Borowski, Laurel A.
Liu, Benmei
Galuska, Deborah A.
Ballard-Barbash, Rachel
Yanovski, Susan Z.
Olster, Deborah H.
Atienza, Audie A.
Smith, Ashley Wilder
TI Pediatricians' and Family Physicians' Weight-Related Care of Children in
the US
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID BODY-MASS INDEX; HEALTH-CARE; OVERWEIGHT CHILDREN; NATIONAL-SURVEY;
OBESITY; ATTITUDES; ADOLESCENTS; PREVENTION; GUIDELINES; BARRIERS
AB Background: Few national data exist to assess primary care physicians' (PCPs') clinical practices with regard to childhood obesity.
Purpose: To survey pediatricians and family practice physicians regarding their assessment, counseling, and management of diet, physical activity, and weight status among pediatric patients in the primary care setting.
Methods: A nationally representative cross-sectional survey of pediatricians and family practice physicians sampled from the American Medical Association (AMA) Masterfile was conducted in 2008 and analyzed in 2010. Outcomes included physicians' self-reported practice behaviors regarding assessments of pediatric patients' weight status, counseling of diet and physical activity, and referrals and follow-ups.
Results: Response rate excluding physicians listed as "no-contact" by the AMA was 73.7% among pediatricians and 66.9% among family physicians. Less than 50% of all PCPs assessed BMI percentiles regularly in children. Eighteen percent of all PCPs reported referring children for further evaluation or management. Fifty-eight percent of all PCPs reported never, rarely, or only sometimes tracking patients over time concerning weight or weight-related behaviors. Pediatricians were more likely than family physicians to assess weight status and provide behavioral counseling (p's<0.001).
Conclusions: Active PCP participation in assessing or managing childhood obesity in the primary care setting appears low relative to the frequency of the problem in the U. S. Interventions to reduce the barriers to physician engagement in the assessment and management of healthy lifestyles are needed to prevent and control childhood obesity. (Am J Prev Med 2011; 41(1): 24-32) (C) 2011 Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine.
C1 [Smith, Ashley Wilder] NCI, Outcomes Res Branch, Appl Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
[Huang, Terry T-K] Kennedy Shriver Natl Inst Child Hlth & Human Dev, Bethesda, MD USA.
[Yanovski, Susan Z.] NIDDK, Div Digest Dis & Nutr, Bethesda, MD USA.
[Olster, Deborah H.] NIH, Off Behav & Social Sci Res, Bethesda, MD 20892 USA.
[Huang, Terry T-K] Univ Nebraska Med Ctr, Dept Hlth Promot & Social & Behav Hlth, Coll Publ Hlth, Omaha, NE USA.
[Galuska, Deborah A.] CDC, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
RP Smith, AW (reprint author), NCI, Outcomes Res Branch, Appl Res Program, Div Canc Control & Populat Sci, 6130 Execut Blvd,MSC 7344,Execut Plaza N,Room 409, Bethesda, MD 20892 USA.
EM smithas@mail.nih.gov
FU National Cancer Institute [N02-PC-61301]
FX Data collection for this survey was supported by the National Cancer
Institute's Contract No. N02-PC-61301.
NR 30
TC 26
Z9 26
U1 1
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD JUL
PY 2011
VL 41
IS 1
BP 24
EP 32
DI 10.1016/j.amepre.2011.03.016
PG 9
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 775OC
UT WOS:000291468700006
PM 21665060
ER
PT J
AU Smith, AW
Borowski, LA
Liu, BM
Galuska, DA
Signore, C
Klabunde, C
Huang, TTK
Krebs-Smith, SM
Frank, E
Pronk, N
Ballard-Barbash, R
AF Smith, Ashley Wilder
Borowski, Laurel A.
Liu, Benmei
Galuska, Deborah A.
Signore, Caroline
Klabunde, Carrie
Huang, Terry T-K
Krebs-Smith, Susan M.
Frank, Erica
Pronk, Nico
Ballard-Barbash, Rachel
TI US Primary Care Physicians' Diet-, Physical Activity-, and
Weight-Related Care of Adult Patients
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID NATIONAL TRENDS; PROFESSIONALS; ATTITUDES; OBESITY; PRACTITIONERS;
SPECIALTY; BARRIERS; PROMOTE; WOMEN
AB Background: Overweight and obesity are substantial problems in the U. S., but few national studies exist on primary care physicians' (PCPs') clinical practices regarding overweight and obesity.
Purpose: To profile diet, physical activity, and weight control practice patterns of PCPs who treat adults.
Methods: A nationally representative survey of 1211 PCPs sampled from the American Medical Association's Masterfile was conducted in 2008 and analyzed in 2010. Outcomes included PCPs' assessment, counseling, referral, and follow-up of diet, physical activity, and weight control in adult patients with and without chronic disease and PCPs' use of pharmacologic treatments and surgical referrals for overweight and obesity.
Results: The survey response rate was 64.5%. Half of PCPs (49%) reported recording BMI regularly. Fewer than 50% reported always providing specific guidance on diet, physical activity, or weight control. Regardless of patients' chronic disease status, <10% of PCPs always referred patients for further evaluation/management and <22% reported always systematically tracking patients over time concerning weight or weight-related behaviors. Overall, PCPs were more likely to counsel on physical activity than on diet or weight control (p's<0.05). More than 70% of PCPs reported ever using pharmacologic treatments to treat overweight and 86% had referred for obesity-related surgery.
Conclusions: PCPs' assessment and behavioral management of overweight and obesity in adults is at a low level relative to the magnitude of the problem in the U. S. Further research is needed to understand barriers to providing care and to improve physician engagement in tracking and managing healthy lifestyles in U. S. adults. (Am J Prev Med 2011; 41(1): 33-42) (C) 2011 Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine.
C1 [Smith, Ashley Wilder] NCI, Outcomes Res Branch, Appl Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
[Signore, Caroline] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Pregnancy & Perinatol Branch, Bethesda, MD USA.
[Galuska, Deborah A.] CDC, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
[Frank, Erica] Univ British Columbia, Dept Family Practice, Sch Populat & Publ Hlth, Vancouver, BC V5Z 1M9, Canada.
[Pronk, Nico] JourneyWell HealthPartners Res Fdn, Minneapolis, MN USA.
[Pronk, Nico] Harvard Univ, Sch Publ Hlth, Dept Soc Human Dev & Hlth, Boston, MA 02115 USA.
RP Smith, AW (reprint author), NCI, Outcomes Res Branch, Appl Res Program, Div Canc Control & Populat Sci, 6130 Execut Blvd,MSC 7344,Execut Plaza N,Room 409, Bethesda, MD 20892 USA.
EM smithas@mail.nih.gov
FU National Cancer Institute [N02-PC-61301]
FX Data collection for this survey was supported by the National Cancer
Institute's Contract No. N02-PC-61301.
NR 41
TC 35
Z9 38
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD JUL
PY 2011
VL 41
IS 1
BP 33
EP 42
DI 10.1016/j.amepre.2011.03.017
PG 10
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 775OC
UT WOS:000291468700007
PM 21665061
ER
PT J
AU Perry, GS
Presley-Cantrell, LR
Edwards, VJ
AF Perry, Geraldine S.
Presley-Cantrell, Letitia R.
Edwards, Valerie J.
TI ADVERSE CHILDHOOD EVENTS IN THE MENTAL HEALTH DISCUSSION RESPONSE
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Letter
ID PREVENTION; ADULTS
C1 [Perry, Geraldine S.; Presley-Cantrell, Letitia R.; Edwards, Valerie J.] Ctr Dis Control & Prevent, Emerging Invest & Analyt Methods Branch, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
RP Perry, GS (reprint author), Ctr Dis Control & Prevent, Emerging Invest & Analyt Methods Branch, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop K-67, Atlanta, GA 30341 USA.
EM gperry@cdc.gov
NR 8
TC 0
Z9 0
U1 0
U2 3
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD JUL
PY 2011
VL 101
IS 7
BP 1157
EP 1157
DI 10.2105/AJPH.2011.300241
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 776DG
UT WOS:000291514100002
ER
PT J
AU Oren, E
Winston, CA
Pratt, R
Robison, VA
Narita, M
AF Oren, Eyal
Winston, Carla A.
Pratt, Robert
Robison, Valerie A.
Narita, Masahiro
TI Epidemiology of Urban Tuberculosis in the United States, 2000-2007
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID DIRECTLY OBSERVED THERAPY; FOREIGN-BORN PERSONS; NEW-YORK-CITY;
POPULATION HEALTH; SAN-FRANCISCO; NEW-JERSEY; CITIES; TRANSMISSION;
ELIMINATION; OUTBREAK
AB Objectives. We investigated tuberculosis (TB) incidence rates and characteristics of patients with TB in large US cities.
Methods. Using the Centers for Disease Control and Prevention's National Tuberculosis Surveillance System data, we categorized 48 cities annually from 2000 to 2007 as reporting decreasing or nondecreasing rates with Joinpoint analysis. We compared demographic, clinical, and treatment characteristics of patients with TB using bivariate and multivariate analyses.
Results. We found that 42448 patients with TB in 48 cities accounted for 36% of all US patients with TB; these cities comprised 15% of the US population. The average TB incidence rate in the 48 cities (12.1 per 100000) was higher than that in the US excluding the cities (3.8 per 100000) but decreased at a faster rate. Nineteen cities had decreasing rates; 29 cities had nondecreasing rates. Patient characteristics did not conclusively distinguish decreasing and nondecreasing rate cities.
Conclusions. A significant TB burden occurs in large US cities. More than half (60%) of the selected cities did not show decreasing TB incidence rates. Studies of city-level variations in migration, socioeconomic status, and resources are needed to improve urban TB control. (Am J Public Health. 2011;101:1256-1263. doi:10.2105/AJPH.2010.300030)
C1 [Oren, Eyal; Narita, Masahiro] Publ Hlth Seattle & King Cty, TB Control Program, Harborview Med Ctr, Seattle, WA 98104 USA.
[Winston, Carla A.; Robison, Valerie A.] Ctr Dis Control & Prevent, Div TB Eliminat, Druid Hills, GA USA.
[Pratt, Robert] Northrop Grumman Informat Syst, Century City, CA USA.
[Narita, Masahiro] Univ Washington, Div Pulm & Crit Care, Seattle, WA 98195 USA.
RP Oren, E (reprint author), Publ Hlth Seattle & King Cty, TB Control Program, Harborview Med Ctr, 325 9th Ave, Seattle, WA 98104 USA.
EM eyal.oren@kingcounty.org
OI Oren, Eyal/0000-0001-7817-3516
FU National Association of County and City Health Officials
FX The National Association of County and City Health Officials provided
general support for this work.
NR 43
TC 15
Z9 15
U1 1
U2 5
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD JUL
PY 2011
VL 101
IS 7
BP 1256
EP 1263
DI 10.2105/AJPH.2010.300030
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 776DG
UT WOS:000291514100026
PM 21566031
ER
PT J
AU Des Jarlais, DC
Arasteh, K
McKnight, C
Hagan, H
Perlman, DC
Semaan, S
AF Des Jarlais, Don C.
Arasteh, Kamyar
McKnight, Courtney
Hagan, Holly
Perlman, David C.
Semaan, Salaam
TI Associations Between Herpes Simplex Virus Type 2 and HCV With HIV Among
Injecting Drug Users in New York City: The Current Importance of Sexual
Transmission of HIV
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; HEPATITIS-C-VIRUS; RISK; INFECTION;
PREVENTION; EPIDEMIC; COHORT; WOMEN; SEROPREVALENCE; METAANALYSIS
AB Objectives. We examined relationships between herpes simplex virus type 2 (HSV-2), a biomarker for sexual risk, and HCV, a biomarker for injecting risk, with HIV among injecting drug users (IDUs) who began injecting after large-scale expansion of syringe exchange programs in New York City.
Methods. We recruited 337 heroin and cocaine users who began injecting in 1995 or later from persons entering drug detoxification. We administered a structured interview covering drug use and HIV risk behavior and collected serum samples for HIV, HCV, and HSV-2 testing.
Results. HIV prevalence was 8%, HSV-2 39%, and HCV 55%. We found a significant association between HSV-2 and HIV (odds ratio [OR]=7.9; 95% confidence interval [CI]=2.9, 21.4) and no association between HCV and HIV (OR=1.14; 95% CI=0.5, 2.6). Black IDUs had the highest prevalence of HSV-2 (76%) and HIV (24%) but the lowest prevalence of HCV (34%).
Conclusions. Most HIV infections among these IDUs occurred through sexual transmission. The relative importance of injecting versus sexual transmission of HIV may be critical for understanding racial/ethnic disparities in HIV infection. (Am J Public Health. 2011;101:1277-1283. doi:10.2105/AJPH.2011.300130)
C1 [Des Jarlais, Don C.; Arasteh, Kamyar; McKnight, Courtney; Perlman, David C.] Beth Israel Deaconess Med Ctr, Baron Edmond de Rothschild Chem Dependency Inst, New York, NY 10038 USA.
[Hagan, Holly] NYU, Sch Nursing, New York, NY USA.
[Semaan, Salaam] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Des Jarlais, DC (reprint author), Beth Israel Deaconess Med Ctr, Baron Edmond de Rothschild Chem Dependency Inst, 160 Water St,24th Floor, New York, NY 10038 USA.
FU National Institutes of Health [DA 03574, 2 P30 DA 11041]
FX This research was supported by the National Institutes of Health (grants
DA 03574 and 2 P30 DA 11041).
NR 44
TC 30
Z9 31
U1 1
U2 8
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
EI 1541-0048
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD JUL
PY 2011
VL 101
IS 7
BP 1277
EP 1283
DI 10.2105/AJPH.2011.300130
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 776DG
UT WOS:000291514100029
PM 21566021
ER
PT J
AU Borse, NN
Hyder, AA
Streatfield, PK
Arifeen, SE
Bishai, D
AF Borse, N. N.
Hyder, A. A.
Streatfield, P. K.
Arifeen, S. E.
Bishai, D.
TI Childhood drowning and traditional rescue measures: case study from
Matlab, Bangladesh
SO ARCHIVES OF DISEASE IN CHILDHOOD
LA English
DT Article
ID DEVELOPING-COUNTRY; VERBAL AUTOPSY; RISK-FACTORS; RURAL AREA; CHILDREN;
PREVENTION; INJURIES; DEATHS; EPIDEMIOLOGY
AB Recent mortality data indicate that approximately half a million people drown each year worldwide, with more than 97% of such deaths occurring in low-income and middle-income countries. The purpose of this study was to examine verbal autopsy data on the circumstances of childhood drowning in Matlab, Bangladesh. The study analysed 10 years (1996-2005) of data which reported 489 deaths in children under 5 years and recorded preimmersion, immersion and postimmersion events. The data summarised household characteristics, age, gender and time of drowning event. The study also examined traditional rescue methods performed on children who were removed from the water OR found drowning. Of 489 deaths, 57% were aged 1-2 years and had a drowning mortality rate of 521 per 100 000 children. Most drowning events occurred during the morning (68%), in ponds (69%), and while the mother was busy doing household chores (70%). Traditional rescue methods were attempted in 55% of children and the most frequently reported measure was to spin the child over head (35%). Only 3% of families tried to perform resuscitation. Verbal autopsy data for Matlab is a useful resource for childhood injury research in a low-income country. The study is one of the first to publish data on traditional rescue practices performed on drowning children in rural Bangladesh. The findings suggest that interventions should be designed using locally identified risk factors to reduce childhood drowning incidents. Community-based resuscitation techniques and emergency medical systems are needed to improve postimmersion recovery of the child.
C1 [Borse, N. N.; Hyder, A. A.] Johns Hopkins Bloomberg Sch Publ Hlth, Hlth Syst Program, Dept Int Hlth, Baltimore, MD USA.
[Borse, N. N.; Streatfield, P. K.; Arifeen, S. E.] Int Ctr Diarrhoeal Dis Res, Publ Hlth Sci Div, Dhaka 1000, Bangladesh.
[Hyder, A. A.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Int Injury Res Unit, Baltimore, MD USA.
[Bishai, D.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Baltimore, MD USA.
RP Borse, NN (reprint author), CDC, Ctr Global Hlth, 1600 Clifton Rd,MS E-41, Atlanta, GA 30329 USA.
EM nborse@cdc.gov
OI Bishai, David/0000-0003-0714-9062
FU United States Agency for International Development (USAID)
FX This research was funded by the United States Agency for International
Development (USAID). This project was also partly supported by USAID
Family Health and Child Survival Cooperative Agreement through Global
Research Activity to Johns Hopkins University.
NR 47
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Z9 7
U1 0
U2 7
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-9888
J9 ARCH DIS CHILD
JI Arch. Dis. Child.
PD JUL
PY 2011
VL 96
IS 7
BP 675
EP 680
DI 10.1136/adc.2010.202010
PG 6
WC Pediatrics
SC Pediatrics
GA 775QO
UT WOS:000291477900016
PM 21398317
ER
PT J
AU Jayatilaka, NK
Montesano, MA
Whitehead, RD
Schloth, SJ
Needham, LL
Barr, DB
AF Jayatilaka, Nayana K.
Montesano, M. Angela
Whitehead, Ralph D., Jr.
Schloth, Sara J.
Needham, Larry L.
Barr, Dana Boyd
TI High-Throughput Sample Preparation for the Quantitation of Acephate,
Methamidophos, Omethoate, Dimethoate, Ethylenethiourea, and
Propylenethiourea in Human Urine Using 96-Well-Plate Automated
Extraction and High-Performance Liquid Chromatography-Tandem Mass
Spectrometry
SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
ID ORGANOPHOSPHORUS PESTICIDES; GAS-CHROMATOGRAPHY; HUMAN SERUM; EXPOSURE;
QUANTIFICATION; TOXICOLOGY; WORKERS; WATER; FARM
AB Acephate, methamidophos, o-methoate, and dimethoate are organophosphorus pesticides, and ethylenethiouria and propylenethiourea are two metabolites from the bisdithiocarbamate fungicide family. They are some of the most widely used pesticides and fungicides in agriculture both domestically and abroad. The existing high-performance liquid chromatography (HPLC)-tandem mass spectrometry (MS/MS) method for the measurement of these compounds in human urine was improved by using a 96-well plate format sample preparation; the use of HPLC-MS/MS was comparable with a concentration range of 0.125 to 50 ng/ml. Deuterium-labeled acephate, ethylenethiouria, and methamidophos were used as internal standards. The sample preparation procedure, in the 96-well format with a 0.8-ml urine sample size, uses lyophilization of samples, followed by extraction with dichloromethane. The analytes were chromatographed on a Zorbax SB-C3 (4.6 x 150 mm, 5.0-mu m) column with gradient elution by using 0.1% formic acid in aqueous solution (solvent A) and 0.1% formic acid in methanol (solvent B) mobile phase at a flow rate of 1 ml/min. Quantitative analysis was performed by atmospheric pressure chemical ionization source in positive ion mode using multiple-reaction monitoring of the precursor-to-product ion pairs for the analytes on a TSQ Quantum Ultra HPLC-MS/MS. Repeated analyses of urine samples spiked with high (15 ng/ml), medium (5 ng/ml), and low (1 ng/ml) concentrations of the analytes gave relative SDs of < 13%. The limits of detection were in the range of 0.004-0.01 ng/ml. The method also has high accuracy, high precision, and excellent extraction recovery. Furthermore, the improved sample preparation method decreased the cost and labor required while effectively doubling the analytic throughput with minimal matrix effect.
C1 [Jayatilaka, Nayana K.; Montesano, M. Angela; Whitehead, Ralph D., Jr.; Schloth, Sara J.; Needham, Larry L.; Barr, Dana Boyd] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
RP Montesano, MA (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
EM AHM2@cdc.gov
RI Needham, Larry/E-4930-2011; Barr, Dana/E-6369-2011; Barr,
Dana/E-2276-2013
NR 36
TC 7
Z9 7
U1 4
U2 34
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-4341
J9 ARCH ENVIRON CON TOX
JI Arch. Environ. Contam. Toxicol.
PD JUL
PY 2011
VL 61
IS 1
BP 59
EP 67
DI 10.1007/s00244-010-9593-3
PG 9
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 777FJ
UT WOS:000291601000004
PM 20878153
ER
PT J
AU Doshi, SJ
Sandhu, HS
Venczel, LV
Hymbaugh, KJ
Deshpande, JM
Pallansch, MA
Bahl, S
Wenger, JD
Cochi, SL
AF Doshi, Sucheta J.
Sandhu, Hardeep S.
Venczel, Linda V.
Hymbaugh, Karen J.
Deshpande, Jagadish M.
Pallansch, Mark A.
Bahl, Sunil
Wenger, Jay D.
Cochi, Steve L.
TI Poliomyelitis-Related Case-Fatality Ratio in India, 2002-2006
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID ORAL POLIOVIRUS VACCINE; ACUTE FLACCID PARALYSIS; ATTACK RATE;
SURVEILLANCE; OUTBREAK
AB Background. On the basis of studies from developed countries, the case-fatality ratio (CFR) of poliomyelitis generally ranges from 2%-5% among children <5 years of age to 10%-30% among adults. However, little information is available for poliomyelitis-related CFR in developing countries. We conducted a study to determine the CFR in India, 1 of the 4 remaining countries with endemic wild poliovirus (WPV) circulation, during outbreaks of WPV infection during 2002 and 2006 and during the inter-epidemic years of 2003-2005.
Methods. We conducted a descriptive analysis with use of data from the acute flaccid paralysis surveillance system in India. Variables analyzed included age, caregiver-reported vaccination status, date of paralysis onset, laboratory results, final case classification, and survival outcome. Our analysis also accounted for surveillance changes that occurred in 2005, impacting case definitions and final classification.
Results. In 2006, 45 deaths occurred among 676 WPV cases in India, yielding a CFR of 6.7%. By comparison, in 2002, there were 66 deaths among 1600 reported WPV cases (CFR, 4.2%) and during 2002-2005, CFR was 1.5%-5.2%. All 45 deaths were among 644 (95%) WPV cases in children aged <5 years (CFR, 7.0%). Among those who died, 33 (73%) were children aged <2 years (CFR, 7.1%).
Conclusions. The CFR among children aged <2 years in India is high compared with previously published CFRs for young children, in part because of improved case finding through enhanced surveillance techniques. Fatal cases emphasize the lethal nature of the disease and the importance of achieving polio eradication in India.
C1 [Doshi, Sucheta J.; Sandhu, Hardeep S.; Venczel, Linda V.; Cochi, Steve L.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Global Immunizat Div, Atlanta, GA 30333 USA.
[Doshi, Sucheta J.] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Atlanta, GA 30333 USA.
[Pallansch, Mark A.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Hymbaugh, Karen J.] World Hlth Org, Reg Off SE Asia, New Delhi, India.
[Bahl, Sunil; Wenger, Jay D.] Natl Polio Surveillance Project India, New Delhi, India.
[Deshpande, Jagadish M.] Enterovirus Res Ctr, Mumbai, Maharashtra, India.
RP Sandhu, HS (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Global Immunizat Div, MS E-05,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM hsandhu@cdc.gov
OI Deshpande, Jagadish/0000-0001-5194-0375
FU Global Polio Eradication Initiative
FX The funding for poliomyelitis surveillance is provided by the Global
Polio Eradication Initiative.
NR 25
TC 2
Z9 2
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD JUL
PY 2011
VL 53
IS 1
BP 13
EP 19
DI 10.1093/cid/cir332
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 776QA
UT WOS:000291550700004
PM 21653297
ER
PT J
AU Gardner, TJ
Fitzgerald, C
Xavier, C
Klein, R
Pruckler, J
Stroika, S
McLaughlin, JB
AF Gardner, Tracie J.
Fitzgerald, Collette
Xavier, Catherine
Klein, Ron
Pruckler, Janet
Stroika, Steven
McLaughlin, Joseph B.
TI Outbreak of Campylobacteriosis Associated With Consumption of Raw Peas
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID UNITED-STATES; JEJUNI; INFECTION; COMMUNITY
AB Background. Campylobacter jejuni is a leading cause of acute gastroenteritis worldwide, and most cases are identified as sporadic events rather than as parts of recognized outbreaks. We report findings from a substantial 2008 campylobacteriosis outbreak with general implications for fresh produce safety.
Methods. We conducted a matched case-control study to determine the source of the outbreak and enhanced surveillance to identify additional cases. Clinical and environmental specimens were tested for Campylobacter, and isolates were subtyped by pulsed-field gel electrophoresis (PFGE).
Results. By routine surveillance, we identified 63 cases of laboratory-confirmed infection. Only raw peas, consumed by 30 (67%) of 45 case-patients and by 15 (17%) of 90 control participants, were associated with illness (adjusted odds ratio: 8.2; P<.001). An additional 69 patients (26 laboratory-confirmed) who reported eating raw peas within 10 days of illness onset were identified through enhanced surveillance. In all, 5 cases were hospitalized, and Guillain-Barre syndrome developed in 1 case; none died. The implicated pea farm was located near a Sandhill crane (Grus canadensis) stopover and breeding site. Of 36 environmental samples collected, 16 were positive for C. jejuni-14 crane-feces samples and 2 pea samples. We identified 25 unique combined SmaI-KpnI PFGE patterns among clinical isolates; 4 of these combined PFGE patterns identified in 15 of 55 human isolates were indistinguishable from PFGE patterns identified in environmental samples.
Conclusions. This investigation established a rare laboratory-confirmed link between a campylobacterosis outbreak and an environmental source and identified wild birds as an underrecognized source of produce contamination.
C1 [Gardner, Tracie J.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA.
[Gardner, Tracie J.; McLaughlin, Joseph B.] Alaska Dept Hlth & Social Serv, Epidemiol Sect, Alaska State Publ Hlth Labs, Div Publ Hlth, Anchorage, AK USA.
[Fitzgerald, Collette; Pruckler, Janet; Stroika, Steven] Ctr Dis Control & Prevent, Enter Dis Lab Branch, Atlanta, GA 30333 USA.
[Klein, Ron] Alaska Dept Environm Conservat, Anchorage, AK USA.
RP Gardner, TJ (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, 1600 Clifton Rd NE,Mailstop E-05, Atlanta, GA 30333 USA.
EM hgj7@cdc.gov
FU International Association for Food Protection; Division of Public
Health, Anchorage, Alaska
FX This work was supported by the International Association for Food
Protection (Centers for Disease Control and Prevention, for T. G.); and
the Division of Public Health, Anchorage, Alaska.
NR 27
TC 37
Z9 38
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD JUL
PY 2011
VL 53
IS 1
BP 26
EP 32
DI 10.1093/cid/cir249
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 776QA
UT WOS:000291550700006
PM 21653299
ER
PT J
AU Gupta, N
Limbago, BM
Patel, JB
Kallen, AJ
AF Gupta, Neil
Limbago, Brandi M.
Patel, Jean B.
Kallen, Alexander J.
TI Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
ID KLEBSIELLA-PNEUMONIAE CARBAPENEMASE; METALLO-BETA-LACTAMASE;
OUTER-MEMBRANE PROTEIN; ACUTE-CARE FACILITIES; UNITED-STATES;
PSEUDOMONAS-AERUGINOSA; IMIPENEM RESISTANCE; SUSCEPTIBILITY PATTERNS; K.
PNEUMONIAE; NEW-YORK
AB Over the past 10 years, dissemination of Klebsiella pneumoniae carbapenemase (KPC) has led to an increase in the prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Infections caused by CRE have limited treatment options and have been associated with high mortality rates. In the previous year, other carbapenemase subtypes, including New Delhi metallo-beta-lactamase, have been identified among Enterobacteriaceae in the United States. Like KPC, these enzymes are frequently found on mobile genetic elements and have the potential to spread widely. As a result, preventing both CRE transmission and CRE infections have become important public health objectives. This review describes the current epidemiology of CRE in the United States and highlights important prevention strategies.
C1 [Gupta, Neil; Limbago, Brandi M.; Patel, Jean B.; Kallen, Alexander J.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
[Gupta, Neil] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA.
RP Gupta, N (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd NE,MS A-35, Atlanta, GA 30333 USA.
EM ngupta1@cdc.gov
NR 48
TC 323
Z9 333
U1 9
U2 53
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD JUL
PY 2011
VL 53
IS 1
BP 60
EP 67
DI 10.1093/cid/cir202
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 776QA
UT WOS:000291550700012
PM 21653305
ER
PT J
AU Mondy, KE
Gottdiener, J
Brooks, JT
AF Mondy, Kristin E.
Gottdiener, John
Brooks, John T.
TI Pulmonary Hypertension in HIV-Infected Individuals Reply
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Letter
ID PRESSURE
C1 [Mondy, Kristin E.] Washington Univ, Sch Med, St Louis, MO USA.
[Mondy, Kristin E.] Univ Texas SW, Austin Program, Austin, TX USA.
[Mondy, Kristin E.] Cent Texas Vet Healthcare Syst, Austin, TX USA.
[Gottdiener, John] Univ Maryland, Baltimore, MD 21201 USA.
[Brooks, John T.] Ctr Dis Control & Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Div HIV AIDS Prevent, Atlanta, GA USA.
RP Mondy, KE (reprint author), Univ Med Ctr Brackenridge, 601 E 15th St,Brackenridge Annex Bldg, Austin, TX 78701 USA.
EM kristinmd@swbell.net
NR 4
TC 0
Z9 0
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD JUL
PY 2011
VL 53
IS 1
DI 10.1093/cid/cir285
PG 2
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 776QA
UT WOS:000291550700018
ER
PT J
AU Day, LW
Espey, DK
Madden, E
Segal, M
Terdiman, JP
AF Day, Lukejohn W.
Espey, David K.
Madden, Erin
Segal, Mark
Terdiman, Jonathan P.
TI Screening Prevalence and Incidence of Colorectal Cancer Among American
Indian/Alaskan Natives in the Indian Health Service
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Article
DE Screening; Incidence; Colonoscopy; Health disparity
ID ALASKA-NATIVES; UNITED-STATES; FEATURING CANCER; AVERAGE-RISK;
KNOWLEDGE; BEHAVIORS; SURVEILLANCE; PREDICTORS; PHYSICIANS; BARRIERS
AB Studies on colorectal cancer (CRC) screening and incidence among American Indian/Alaska Natives (AI/AN) are few.
Our aim was to determine CRC screening prevalence and to calculate CRC incidence among AI/AN receiving care within the Indian Health Service (IHS).
A retrospective cohort study of AI/AN who utilized IHS from 1996 to 2004. AI/AN who were average-risk for CRC and received primary care within IHS were identified by searching the IHS Resource Patient Management System for selected ICD-9/CPT codes (n = 142,051). CRC screening prevalence was calculated and predictors of screening were determined for this group. CRC incidence rates were ascertained for the entire AI/AN population ages 50-80 who received IHS medical care between 1996 and 2004 (n = 283,717).
CRC screening was performed in 4.0% of average-risk AI/AN. CRC screening was more common among women than men (RR = 1.6, 95% CI 1.4-1.7) and among AI/AN living in the Alaska region compared to the Pacific Coast region (RR = 2.5, 95% CI 2.2-2.8) while patients living in the Northern Plains (RR = 0.4, 95% CI 0.3-0.4) were less likely to have been screened. CRC screening was less common among patients with a greater number of primary care visits. The age-adjusted CRC incidence among AI/AN ages 50-80 was 227 cancers per 100,000 person-years.
CRC was common among AI/AN receiving medical care within IHS. However, CRC screening prevalence was far lower than has been reported for the U.S. population.
C1 [Day, Lukejohn W.] San Francisco Gen Hosp 3D, Div Gastroenterol, San Francisco, CA 94110 USA.
[Day, Lukejohn W.; Terdiman, Jonathan P.] Univ Calif San Francisco, Div Gastroenterol, San Francisco, CA 94143 USA.
[Espey, David K.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Albuquerque, NM USA.
[Espey, David K.] Indian Hlth Serv, Div Epidemiol & Dis Prevent, Albuquerque, NM USA.
[Madden, Erin; Segal, Mark] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
RP Day, LW (reprint author), San Francisco Gen Hosp 3D, Div Gastroenterol, 1001 Potrero Ave, San Francisco, CA 94110 USA.
EM lukejohn.day@ucsf.edu
NR 43
TC 8
Z9 8
U1 0
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD JUL
PY 2011
VL 56
IS 7
BP 2104
EP 2113
DI 10.1007/s10620-010-1528-3
PG 10
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 775RU
UT WOS:000291481800028
PM 21234688
ER
PT J
AU Forsberg, LS
Choudhury, B
Leoff, C
Marston, CK
Hoffmaster, AR
Saile, E
Quinn, CP
Kannenberg, EL
Carlson, RW
AF Forsberg, L. Scott
Choudhury, Biswa
Leoff, Christine
Marston, Chung K.
Hoffmaster, Alex R.
Saile, Elke
Quinn, Conrad P.
Kannenberg, Elmar L.
Carlson, Russell W.
TI Secondary cell wall polysaccharides from Bacillus cereus strains G9241,
03BB87 and 03BB102 causing fatal pneumonia share similar glycosyl
structures with the polysaccharides from Bacillus anthracis
SO GLYCOBIOLOGY
LA English
DT Article
DE Bacillus anthracis; Bacillus cereus; cell wall; polysaccharide;
structure
ID O-ANTIGENIC POLYSACCHARIDE; GLYCOGEN BIOSYNTHESIS;
N-ACETYLQUINOVOSAMINE; PROTEINS; SURFACE; IDENTIFICATION; SPECTROSCOPY;
SUBTILIS; UNIQUE; DOMAIN
AB Secondary cell wall polysaccharides (SCWPs) are important structural components of the Bacillus cell wall and contribute to the array of antigens presented by these organisms in both spore and vegetative forms. We previously found that antisera raised to Bacillus anthracis spore preparations cross-reacted with SCWPs isolated from several strains of pathogenic B. cereus, but did not react with other phylogenetically related but nonpathogenic Bacilli, suggesting that the SCWP from B. anthracis and pathogenic B. cereus strains share specific structural features. In this study, SCWPs from three strains of B. cereus causing severe or fatal pneumonia (G9241, 03BB87 and 03BB102) were isolated and subjected to structural analysis and their structures were compared to SCWPs from B. anthracis. Complete structural analysis was performed for the B. cereus G9241 SCWP using NMR spectroscopy, mass spectrometry and derivatization methods. The analyses show that SCWPs from B. cereus G9241 has a glycosyl backbone identical to that of B. anthracis SCWP, consisting of multiple trisaccharide repeats of: -> 6)-alpha-d-GlcpNAc-(1 -> 4)-beta-d-ManpNAc-(1 -> 4)-beta-d-GlcpNAc-(1 ->. Both the B. anthracis and pathogenic B. cereus SCWPs are highly substituted at all GlcNAc residues with alpha- and beta-Gal residues, however, only the SCWPs from B. cereus G9241 and 03BB87 carry an additional alpha-Gal substitution at O-3 of ManNAc residues, a feature lacking in the B. anthracis SCWPs. Both the B. anthracis and B. cereus SCWPs are pyruvylated, with an approximate molecular mass of 12,000 Da. The implications of these findings regarding pathogenicity and cell wall structure are discussed.
C1 [Forsberg, L. Scott; Leoff, Christine; Kannenberg, Elmar L.; Carlson, Russell W.] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA.
[Choudhury, Biswa] Univ Calif San Diego, San Diego, CA 92103 USA.
[Marston, Chung K.; Hoffmaster, Alex R.; Saile, Elke; Quinn, Conrad P.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Carlson, RW (reprint author), Univ Georgia, Complex Carbohydrate Res Ctr, 315 Riverbend Rd, Athens, GA 30602 USA.
EM rcarlson@ccrc.uga.edu
FU National Institutes of Health [R21 AI076753]; Department of Energy
[DE-FG02-93ER20097]
FX This work was supported in part by National Institutes of Health (R21
AI076753 to R.W.C.). The Complex Carbohydrate Research Center was
supported in part by Department of Energy (DE-FG02-93ER20097).
NR 31
TC 21
Z9 21
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0959-6658
J9 GLYCOBIOLOGY
JI Glycobiology
PD JUL
PY 2011
VL 21
IS 7
BP 934
EP 948
DI 10.1093/glycob/cwr026
PG 15
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 776IC
UT WOS:000291526700008
PM 21421577
ER
PT J
AU Chandler, JC
Molins, CR
Petersen, JM
Belisle, JT
AF Chandler, Jeffrey C.
Molins, Claudia R.
Petersen, Jeannine M.
Belisle, John T.
TI Differential Chitinase Activity and Production within Francisella
Species, Subspecies, and Subpopulations
SO JOURNAL OF BACTERIOLOGY
LA English
DT Article
ID COMPLETE GENOME SEQUENCE; BACILLUS-CIRCULANS WL-12; UNITED-STATES;
MOLECULAR EPIDEMIOLOGY; III DOMAINS; TULARENSIS; BINDING; HOLARCTICA;
GENES; PHYLOGEOGRAPHY
AB Genotyping of Francisella tularensis (A1a, A1b, A2, and type B) and Francisella novicida has identified multiple differences between species and among F. tularensis subspecies and subpopulations. Variations in virulence, geographic distribution, and ecology are also known to exist among this group of bacteria, despite the >95% nucleotide identity in their genomes. This study expands the description of phenotypic differences by evaluating the ability of F. tularensis and F. novicida to degrade chitin analogs and produce active chitinases. Endochitinase activities were observed to vary among F. tularensis and F. novicida strains. The activity observed for F. tularensis strains was predominantly associated with whole-cell lysates, while the chitinase activity of F. novicida localized to the culture supernatant. In addition, the overall level of chitinase activity differed among the subpopulations of F. tularensis and between the species. Bioinformatic analyses identified two new putative chitinase genes (chiC and chiD), as well as the previously described chiA and chiB. However, the presence of these four open reading frames as intact genes or pseudogenes was found to differ between Francisella species and F. tularensis subspecies and subpopulations. Recombinant production of the putative chitinases and enzymatic evaluations revealed ChiA, ChiB, ChiC, and ChiD possessed dissimilar chitinase activities. These biochemical studies coupled with bioinformatic analyses and the evaluation of chiA and chiC knockouts in F. tularensis A1 and A2 strains, respectively, provided a molecular basis to explain the differential chitinase activities observed among the species and subpopulations of Francisella.
C1 [Chandler, Jeffrey C.; Belisle, John T.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Rocky Mt Reg Ctr Excellence, Ft Collins, CO 80523 USA.
[Molins, Claudia R.; Petersen, Jeannine M.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA.
RP Belisle, JT (reprint author), Colorado State Univ, Dept Microbiol Immunol & Pathol, Rocky Mt Reg Ctr Excellence, Ft Collins, CO 80523 USA.
EM john.belisle@colostate.edu
RI Belisle, John/B-8944-2017
OI Belisle, John/0000-0002-2539-2798
FU National Institutes of Health, National Institute of Allergy and
Infectious Diseases [U54 AI065357]; CCID/ASM
FX This research was supported by the National Institutes of Health,
National Institute of Allergy and Infectious Diseases (grant U54
AI065357). C. R. M. was funded for a portion of this study by CCID/ASM
as a postdoctoral fellow.
NR 53
TC 7
Z9 7
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0021-9193
J9 J BACTERIOL
JI J. Bacteriol.
PD JUL
PY 2011
VL 193
IS 13
BP 3265
EP 3275
DI 10.1128/JB.00093-11
PG 11
WC Microbiology
SC Microbiology
GA 777CS
UT WOS:000291592600011
PM 21531796
ER
PT J
AU Carroll, SA
Reynes, JM
Khristova, ML
Andriamandimby, SF
Rollin, PE
Nichol, ST
AF Carroll, Serena A.
Reynes, Jean-Marc
Khristova, Marina L.
Andriamandimby, Soa Fy
Rollin, Pierre E.
Nichol, Stuart T.
TI Genetic Evidence for Rift Valley Fever Outbreaks in Madagascar Resulting
from Virus Introductions from the East African Mainland rather than
Enzootic Maintenance
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID RECENT COMMON ANCESTRY; SEQUENCE ALIGNMENT; CATTLE; KENYA; HEPATITIS;
TANZANIA; COAST
AB Rift Valley fever virus (RVFV), a mosquito-borne phlebovirus, has been detected in Madagascar since 1979, with occasional outbreaks. In 2008 to 2009, a large RVFV outbreak was detected in Malagasy livestock and humans during two successive rainy seasons. To determine whether cases were due to enzootic maintenance of the virus within Madagascar or to importation from the East African mainland, nine RVFV whole genomic sequences were generated for viruses from the 1991 and 2008 Malagasy outbreaks. Bayesian coalescent analyses of available whole S, M, and L segment sequences were used to estimate the time to the most recent common ancestor for the RVFVs. The 1979 Madagascar isolate shared a common ancestor with strains on the mainland around 1972. The 1991 Madagascar isolates were in a clade distinct from that of the 1979 isolate and shared a common ancestor around 1987. Finally, the 2008 Madagascar viruses were embedded within a large clade of RVFVs from the 2006-2007 outbreak in East Africa and shared a common ancestor around 2003 to 2004. These results suggest that the most recent Madagascar outbreak was caused by a virus likely arriving in the country some time between 2003 and 2008 and that this outbreak may be an extension of the 2006-2007 East African outbreak. Clustering of the Malagasy sequences into subclades indicates that the viruses have continued to evolve during their short-term circulation within the country. These data are consistent with the notion that RVFV outbreaks in Madagascar result not from emergence from enzootic cycles within the country but from recurrent virus introductions from the East African mainland.
C1 [Carroll, Serena A.; Rollin, Pierre E.; Nichol, Stuart T.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA.
[Reynes, Jean-Marc; Andriamandimby, Soa Fy] Ctr Dis Control & Prevent, Biotechnol Core Facil Branch, Atlanta, GA 30333 USA.
[Khristova, Marina L.] Inst Pasteur Madagascar, Virol Unit, Antananarivo 101, Madagascar.
RP Rollin, PE (reprint author), 1600 Clifton Rd,MS G-14, Atlanta, GA 30333 USA.
EM prollin@cdc.gov; snichol@cdc.gov
RI Reynes, Jean-Marc/M-6108-2014
NR 31
TC 34
Z9 34
U1 1
U2 10
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JUL
PY 2011
VL 85
IS 13
BP 6162
EP 6167
DI 10.1128/JVI.00335-11
PG 6
WC Virology
SC Virology
GA 775CG
UT WOS:000291434300007
PM 21507967
ER
PT J
AU Ramachandran, S
Campo, DS
Dimitrova, ZE
Xia, GL
Purdy, MA
Khudyakov, YE
AF Ramachandran, Sumathi
Campo, David S.
Dimitrova, Zoya E.
Xia, Guo-liang
Purdy, Michael A.
Khudyakov, Yury E.
TI Temporal Variations in the Hepatitis C Virus Intrahost Population during
Chronic Infection
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID T-CELL RESPONSES; HYPERVARIABLE REGION; SEQUENCE VARIATION;
GENETIC-VARIATION; LIVER-DISEASE; EVOLUTION; SELECTION; NETWORKS; MODEL;
TREES
AB The intrahost evolution of hepatitis C virus (HCV) holds keys to understanding mechanisms responsible for the establishment of chronic infections and to development of a vaccine and therapeutics. In this study, intrahost variants of two variable HCV genomic regions, HVR1 and NS5A, were sequenced from four treatment-naive chronically infected patients who were followed up from the acute stage of infection for 9 to 18 years. Median-joining network analysis indicated that the majority of the HCV intrahost variants were observed only at certain time points, but some variants were detectable at more than one time point. In all patients, these variants were found organized into communities or subpopulations. We hypothesize that HCV intrahost evolution is defined by two processes: incremental changes within communities through random mutation and alternations between coexisting communities. The HCV population was observed to incrementally evolve within a single community during approximately the first 3 years of infection, followed by dispersion into several subpopulations. Two patients demonstrated this pattern of dispersion for the rest of the observation period, while HCV variants in the other two patients converged into another single subpopulation after similar to 9 to 12 years of dispersion. The final subpopulation in these two patients was under purifying selection. Intrahost HCV evolution in all four patients was characterized by a consistent increase in negative selection over time, suggesting the increasing HCV adaptation to the host late in infection. The data suggest specific staging of HCV intrahost evolution.
C1 [Ramachandran, Sumathi; Campo, David S.; Dimitrova, Zoya E.; Xia, Guo-liang; Purdy, Michael A.; Khudyakov, Yury E.] Ctr Dis Control & Prevent, Mol Epidemiol & Bioinformat Lab, Div Viral Hepatitis, Atlanta, GA 30333 USA.
RP Khudyakov, YE (reprint author), Ctr Dis Control & Prevent, Mol Epidemiol & Bioinformat Lab, Div Viral Hepatitis, 1600 Clifton Rd, Atlanta, GA 30333 USA.
EM yek0@cdc.gov
RI Campo, David S./C-5072-2011
OI Campo, David S./0000-0002-8970-3436
NR 56
TC 44
Z9 45
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JUL
PY 2011
VL 85
IS 13
BP 6369
EP 6380
DI 10.1128/JVI.02204-10
PG 12
WC Virology
SC Virology
GA 775CG
UT WOS:000291434300027
PM 21525348
ER
PT J
AU Garcia-Lerma, JG
Aung, W
Cong, ME
Zheng, Q
Youngpairoj, AS
Mitchell, J
Holder, A
Martin, A
Kuklenyik, S
Luo, W
Lin, CYC
Hanson, DL
Kersh, E
Pau, CP
Ray, AS
Rooney, JF
Lee, WA
Heneine, W
AF Garcia-Lerma, J. Gerardo
Aung, Wutyi
Cong, Mian-er
Zheng, Qi
Youngpairoj, Ae S.
Mitchell, James
Holder, Angela
Martin, Amy
Kuklenyik, Susan
Luo, Wei
Lin, Carol Yen-Chin
Hanson, Debra L.
Kersh, Ellen
Pau, Chou-Pong
Ray, Adrian S.
Rooney, James F.
Lee, William A.
Heneine, Walid
TI Natural Substrate Concentrations Can Modulate the Prophylactic Efficacy
of Nucleotide HIV Reverse Transcriptase Inhibitors
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; TENOFOVIR DISOPROXIL FUMARATE; T-CELL
DEPLETION; ANTIRETROVIRAL THERAPY; GASTROINTESTINAL-TRACT; INFECTION;
NUCLEOSIDE; MACAQUES; PREVENTION; PRODRUG
AB Preexposure prophylaxis (PrEP) with antiretroviral drugs is a novel human immunodeficiency virus (HIV) prevention strategy. It is generally thought that high systemic and mucosal drug levels are sufficient for protection. We investigated whether GS7340, a next-generation tenofovir (TFV) prodrug that effectively delivers tenofovir diphosphate (TFV-DP) to lymphoid cells and tissues, could protect macaques against repeated weekly rectal simian-human immunodeficiency virus (SHIV) exposures. Macaques received prophylactic GS7340 treatment 3 days prior to each virus exposure. At 3 days postdosing, TFV-DP concentrations in peripheral blood mononuclear cells (PBMCs) were about 50-fold higher than those seen with TFV disoproxil fumarate (TDF), and they remained above 1,000 fmol/10(6) cells for as long as 7 days. TFV-DP accumulated in lymphoid and rectal tissues, with concentrations at 3 days exceeding 500 fmol/10(6) mononuclear cells. Despite high mucosal and systemic TFV levels, GS7340 was not protective. Since TFV-DP blocks reverse transcription by competing with the natural dATP substrate, we measured dATP contents in peripheral lymphocytes, lymphoid tissue, and rectal mononuclear cells. Compared to those in circulating lymphocytes and lymphoid tissue, rectal lymphocytes had 100-fold higher dATP concentrations and dATP/TFV-DP ratios, likely reflecting the activated status of the cells and suggesting that TFV-DP may be less active at the rectal mucosa. Our results identify dATP/TFV-DP ratios as a possible correlate of protection by TFV and suggest that natural substrate concentrations at the mucosa will likely modulate the prophylactic efficacy of nucleotide reverse transcriptase inhibitors.
C1 [Garcia-Lerma, J. Gerardo; Aung, Wutyi; Cong, Mian-er; Zheng, Qi; Youngpairoj, Ae S.; Mitchell, James; Holder, Angela; Martin, Amy; Luo, Wei; Lin, Carol Yen-Chin; Hanson, Debra L.; Kersh, Ellen; Pau, Chou-Pong; Heneine, Walid] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA 30329 USA.
[Kuklenyik, Susan] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30329 USA.
[Ray, Adrian S.; Rooney, James F.; Lee, William A.] Gilead Sci, Foster City, CA USA.
RP Garcia-Lerma, JG (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, 1600 Clifton Rd, Atlanta, GA 30329 USA.
EM GGarcia-Lerma@cdc.gov
RI Lin Lawell, C.-Y. Cynthia/M-6342-2014;
OI Lin Lawell, C.-Y. Cynthia/0000-0003-1014-2101; Ray,
Adrian/0000-0002-3508-3008
NR 38
TC 35
Z9 35
U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JUL
PY 2011
VL 85
IS 13
BP 6610
EP 6617
DI 10.1128/JVI.00311-11
PG 8
WC Virology
SC Virology
GA 775CG
UT WOS:000291434300048
PM 21525346
ER
PT J
AU Duerr, A
Gallo, MF
Warner, L
Jamieson, DJ
Kulczycki, A
Macaluso, M
AF Duerr, Ann
Gallo, Maria F.
Warner, Lee
Jamieson, Denise J.
Kulczycki, Andrzej
Macaluso, Maurizio
TI Assessing Male Condom Failure and Incorrect Use
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
ID PROSTATE-SPECIFIC ANTIGEN; SEXUALLY-TRANSMITTED-DISEASE; MALE LATEX
CONDOM; POLYURETHANE CONDOM; VAGINAL INTERCOURSE; PREEJACULATORY FLUID;
CLINICAL-TRIALS; USE ERRORS; BREAKAGE; SLIPPAGE
AB Background: It has not been well established whether common indices of male condom failure are valid predictors of biologically meaningful exposure during condom use.
Methods: To address this gap, the authors compared self-reported condom malfunctions (i.e., breakage and slippage) and incorrect condom practices to 2 following objective measures of failure: prostate-specific antigen (PSA) detected in vaginal swabs collected after condom use and structural integrity of used condoms. The study, conducted in 2000-2001, evaluated 635 male condoms used by 77 women attending an outpatient, reproductive-health clinic in Birmingham, AL.
Results: Women reported breakage or slippage for 7.9% of condoms; 3.5% of postcoital swabs had moderate or high levels of PSA; and laboratory testing of used condoms revealed breaks (1.1%) and leaks (2.0%). Self-reported breakage and slippage was associated with moderate/high PSA concentrations in postcoital swabs only when the malfunctions were not accompanied by reports of corrective actions to reduce exposure (adjusted odds ratio [aOR], 6.9; 95% confidence interval [CI], 1.8-26.2). Defects observed in postcoital laboratory testing were related to PSA detection (aOR, 8.0; 95% CI, 1.5-42.6). Incorrect practices defined on the condom label were frequent, but not all types were associated with semen exposure. Furthermore, other practices not currently label-defined were associated with semen exposure: touching the tip of the penis with his hands (aOR, 6.2; 95% CI, 2.3-17.0) or with her hands (aOR, 2.8; 95% CI, 1.1-72) before donning the condom.
Conclusions: Used correctly, male condoms afforded good protection based on objective measures of failure.
C1 [Gallo, Maria F.; Warner, Lee; Jamieson, Denise J.; Macaluso, Maurizio] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA.
[Duerr, Ann] Fred Hutchinson Canc Res Ctr, Div Clin Res & Publ Hlth Sci, Seattle, WA 98104 USA.
[Kulczycki, Andrzej] Univ Alabama, Dept Hlth Care Org & Policy, Birmingham, AL USA.
RP Gallo, MF (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Highway,Mail Stop K-34, Atlanta, GA 30341 USA.
EM mgallo@cdc.gov
RI Macaluso, Maurizio/J-2076-2015
OI Macaluso, Maurizio/0000-0002-2977-9690
FU Centers for Disease Control and Prevention; Association of Schools of
Public Health [S0747-18/19]
FX Supported by a cooperative agreement with the Centers for Disease
Control and Prevention and the Association of Schools of Public Health
(S0747-18/19).
NR 39
TC 5
Z9 5
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-5717
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD JUL
PY 2011
VL 38
IS 7
BP 580
EP 586
DI 10.1097/OLQ.0b013e3182096b62
PG 7
WC Infectious Diseases
SC Infectious Diseases
GA 777BD
UT WOS:000291586900002
PM 21278626
ER
PT J
AU Kirkcaldy, RD
Su, JR
Taylor, MM
Koumans, E
Mickey, T
Winscott, M
Kenney, K
Weinstock, HS
AF Kirkcaldy, Robert D.
Su, John R.
Taylor, Melanie M.
Koumans, Emilia
Mickey, Tom
Winscott, Michelle
Kenney, Kerry
Weinstock, Hillard S.
TI Epidemiology of Syphilis Among Hispanic Women and Associations With
Congenital Syphilis, Maricopa County, Arizona
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
AB Objective: We investigated factors associated with high rates of congenital syphilis among Hispanic infants in Maricopa County, AZ.
Methods: Using 2004-2008 syphilis case report data from the state and county health departments, we examined characteristics of pregnant and nonpregnant women with syphilis and their male partners.
Results: During 2004-2008, 970 women were reported to have syphilis: 49% were Hispanic (of whom 49% were non-US citizens), 27% were white, 13% were black, and 8% were American Indian/Alaskan Native. Although 16% of Hispanic noncitizens reported drug use or high-risk sexual behaviors, 64% of these women had a male sex partner who reported drug use or anonymous sex. Hispanic women with syphilis were more likely to be pregnant (37%) than white (15%) or black women (13%) (P < 0.05), and were overrepresented among pregnant women with syphilis. Pregnant Hispanic noncitizens were treated later than pregnant Hispanic citizens (median 28 weeks gestation vs. 21 weeks, P = 0.01).
Conclusions: Innovative congenital syphilis prevention strategies that are relevant to Hispanic women are warranted. Strategies should address the reproductive health and prenatal care needs of Hispanic women, and may include interventions for their male partners.
C1 [Kirkcaldy, Robert D.] Ctr Dis Control & Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Div STD Prevent, Atlanta, GA 30333 USA.
[Kirkcaldy, Robert D.] Ctr Dis Control & Prevent, Off Workforce Dev, Epidem Intelligence Serv, Atlanta, GA 30333 USA.
[Taylor, Melanie M.; Winscott, Michelle; Kenney, Kerry] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA.
[Mickey, Tom] Maricopa Cty Dept Publ Hlth, Phoenix, AZ USA.
RP Kirkcaldy, RD (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Div STD Prevent, 1600 Clifton Rd,MS E-02, Atlanta, GA 30333 USA.
EM rkirkcaldy@cdc.gov
FU Centers for Disease Control and Prevention
FX Supported by the Centers for Disease Control and Prevention.
NR 15
TC 1
Z9 2
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-5717
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD JUL
PY 2011
VL 38
IS 7
BP 598
EP 602
DI 10.1097/OLQ.0b013e318210027d
PG 5
WC Infectious Diseases
SC Infectious Diseases
GA 777BD
UT WOS:000291586900004
PM 21317685
ER
PT J
AU Bohl, DD
Katz, KA
Bernstein, K
Wong, E
Raymond, HF
Klausner, JD
McFarland, W
AF Bohl, Daniel D.
Katz, Kenneth A.
Bernstein, Kyle
Wong, Ernie
Raymond, Henry Fisher
Klausner, Jeffrey D.
McFarland, Willi
TI Prevalence and Correlates of Herpes Simplex Virus Type-2 Infection Among
Men Who Have Sex With Men, San Francisco, 2008
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
ID BEHAVIORAL SURVEILLANCE SYSTEM; LINKED-IMMUNOSORBENT-ASSAY;
UNITED-STATES; HSV SUPPRESSION; DOUBLE-BLIND; HIV RISK; TRANSMISSION;
ACQUISITION; PREVENTION; ACYCLOVIR
AB Background: Most herpes simplex virus type 2 (HSV-2) infections are asymptomatic or unrecognized, so periodic serological surveys are necessary in order to measure the true prevalence of infection, track trends over time, and identify correlates of infection, including coinfection with human immunodeficiency virus (HIV).
Methods: We conducted a community-based, cross-sectional, serological survey among 500 men who have sex with men (MSM) in San Francisco during 2008.
Results: The seroprevalence of HSV-2 infection was 26.1% (95% confidence interval [CI], 18.3-33.9), of HIV infection was 18.6% (95% CI, 13.0-24.4), and of HSV-2/HIV coinfection was 12.0% (95% CI, 7.3-16.8; categories not mutually exclusive). HSV-2 prevalence was 3.7 (95% CI, 2.3-5.9) times as high among HIV-infected MSM as among HIV-uninfected MSM. Strong predictors of HSV-2 infection among both HIV-infected and HIV-uninfected MSM were older age and black race.
Conclusions: The prevalence of HSV-2 infection among MSM in San Francisco is similar to that among MSM nationwide and is higher than that among all men nationwide. Prevalence rates are highly disparate among subpopulations of MSM in San Francisco, with the strongest predictors of infection being HIV-positive serostatus, older age, and black race. Primary prevention of HSV-2, particularly among populations at the highest risk for infection with HSV-2 or HIV, should remain a major public health goal to reduce the substantial morbidity caused by both of these infections.
C1 [Bernstein, Kyle; Wong, Ernie; Raymond, Henry Fisher; Klausner, Jeffrey D.; McFarland, Willi] San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA.
[Bohl, Daniel D.] Univ Calif Berkeley, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA.
[Katz, Kenneth A.] Hlth & Human Serv Agcy, Publ Hlth Serv, HIV STD & Hepatitis Branch, San Diego, CA USA.
[Katz, Kenneth A.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA.
RP McFarland, W (reprint author), San Francisco Dept Publ Hlth, 25 Van Ness Ave,Suite 500, San Francisco, CA 94102 USA.
EM Willi_McFarland@hotmail.com
FU Centers for Disease Control and Prevention [U62 PS000961-01]
FX Supported by Centers for Disease Control and Prevention U62 PS000961-01.
NR 22
TC 6
Z9 8
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-5717
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD JUL
PY 2011
VL 38
IS 7
BP 617
EP 621
DI 10.1097/OLQ.0b013e31820a8c10
PG 5
WC Infectious Diseases
SC Infectious Diseases
GA 777BD
UT WOS:000291586900007
PM 21278625
ER
PT J
AU Sosman, J
MacGowan, R
Margolis, A
Gaydos, CA
Eldridge, G
Moss, S
Flanigan, T
Iqbal, K
Belcher, L
AF Sosman, James
MacGowan, Robin
Margolis, Andrew
Gaydos, Charlotte A.
Eldridge, Gloria
Moss, Susan
Flanigan, Timothy
Iqbal, Kashif
Belcher, Lisa
CA Project START Biol Study Grp
TI Sexually Transmitted Infections and Hepatitis in Men With a History of
Incarceration
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
ID CORRECTIONAL FACILITIES; TRICHOMONAS-VAGINALIS; YOUNG MEN;
HIGH-PREVALENCE; UNITED-STATES; DISEASES; HIV; INMATES; PRISONS; SEX
AB Background: Men entering correctional facilities have high rates of human immunodeficiency virus, sexually transmitted infections (STI), and hepatitis. Many prisons offer screening, treatment, and vaccination services; however, little is known about the rates of these infections in men after release to the community.
Methods: Young men were recruited from prisons in Mississippi, Rhode Island, and Wisconsin as part of a human immunodeficiency virus/STI/hepatitis intervention study. Participants were offered screening for Neisseria gonorrhoeae (GC), Chlamydia trachomatis, trichomoniasis, syphilis, hepatitis B (HBV) and C (HCV) 6 months after release. Logistic regression was performed to identify associations with prevalent infections.
Results: Of 248 eligible men, 178 (71.8%) participated. Their mean age was 22.5 years, and 92% reported multiple lifetime incarcerations. At 6-month postrelease, 79% reported unprotected vaginal or anal sex, and 26% tested positive for 1 or more infections (GC, 1%; C. trachomatis, 12%; trichomoniasis, 8%; syphilis, 0%; HCV, 6%; HBV, 1%). Of all, 55% were susceptible to HBV infection. Active STI (GC, C. trachomatis, or trichomoniasis) was associated with less education (odds ratios [ OR], 2.25; P < 0.05). HCV infection was associated with injection drug use (OR, 69.70; P < 0.05) and being white (OR, 7.54; P < 0.05). HBV susceptibility was associated with older age (OR, 3.02; P < 0.05), more education (OR, 2.39; P < 0.05), or incarceration in Mississippi (OR, 6.69; P < 0.05) or Rhode Island (OR, 2.84; P < 0.05).
Conclusions: Effective screening and prevention programs are needed for this population before and after release from custody to prevent acquisition and further transmission of these infections.
C1 [Sosman, James] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI 53705 USA.
[MacGowan, Robin; Margolis, Andrew; Moss, Susan; Iqbal, Kashif; Belcher, Lisa] Ctr Dis Control & Prevent, Prevent Res Branch, Div HIV AIDS Prevent, Natl Ctr HIV STD & TB Prevent, Atlanta, GA USA.
[Gaydos, Charlotte A.] Johns Hopkins Univ, Div Infect Dis, Baltimore, MD USA.
[Eldridge, Gloria] Univ Alaska, Dept Psychol, Anchorage, AK 99508 USA.
[Flanigan, Timothy] Brown Univ, Sch Med, Miriam Hosp, Dept Med, Providence, RI 02912 USA.
RP Sosman, J (reprint author), Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, 2828 Marshall Court,Ste 100, Madison, WI 53705 USA.
EM jms@medicine.wisc.edu
FU Centers for Disease Control and Prevention (CDC) [414879, 514804,
114812, 97050]
FX Supported by Cooperative Agreement Numbers 414879; 514804; 114812; from
the Centers for Disease Control and Prevention (CDC), under Program
Announcement 97050: HIV and STD Intervention Research for Young Men
Leaving Prison.
NR 42
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U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-5717
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD JUL
PY 2011
VL 38
IS 7
BP 634
EP 639
DI 10.1097/OLQ.0b013e31820bc86c
PG 6
WC Infectious Diseases
SC Infectious Diseases
GA 777BD
UT WOS:000291586900010
PM 21844713
ER
PT J
AU Lyles, RH
Tang, L
Superak, HM
King, CC
Celentano, DD
Lo, YT
Sobel, JD
AF Lyles, Robert H.
Tang, Li
Superak, Hillary M.
King, Caroline C.
Celentano, David D.
Lo, Yungtai
Sobel, Jack D.
TI Validation Data-based Adjustments for Outcome Misclassification in
Logistic Regression An Illustration
SO EPIDEMIOLOGY
LA English
DT Article
ID COVARIATE MEASUREMENT ERROR; ALLOYED GOLD STANDARD; RELATIVE RISK; ODDS
RATIOS; EXPOSURE MISCLASSIFICATION; EPIDEMIOLOGY RESEARCH;
CONFIDENCE-INTERVALS; BACTERIAL VAGINOSIS; MAXIMUM-LIKELIHOOD; STUDY
DESIGNS
AB Misclassification of binary outcome variables is a known source of potentially serious bias when estimating adjusted odds ratios. Although researchers have described frequentist and Bayesian methods for dealing with the problem, these methods have seldom fully bridged the gap between statistical research and epidemiologic practice. In particular, there have been few real-world applications of readily grasped and computationally accessible methods that make direct use of internal validation data to adjust for differential outcome misclassification in logistic regression. In this paper, we illustrate likelihood-based methods for this purpose that can be implemented using standard statistical software. Using main study and internal validation data from the HIV Epidemiology Research Study, we demonstrate how misclassification rates can depend on the values of subject-specific covariates, and we illustrate the importance of accounting for this dependence. Simulation studies confirm the effectiveness of the maximum likelihood approach. We emphasize clear exposition of the likelihood function itself, to permit the reader to easily assimilate appended computer code that facilitates sensitivity analyses as well as the efficient handling of main/external and main/internal validation-study data. These methods are readily applicable under random cross-sectional sampling, and we discuss the extent to which the main/internal analysis remains appropriate under outcome-dependent (case-control) sampling.
C1 [Lyles, Robert H.; Tang, Li; Superak, Hillary M.] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA.
[King, Caroline C.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Celentano, David D.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
[Lo, Yungtai] Montefiore Med Ctr, Bronx, NY 10467 USA.
[Lo, Yungtai] Albert Einstein Coll Med, Bronx, NY 10467 USA.
[Sobel, Jack D.] Wayne State Univ, Sch Med, Dept Med, Detroit, MI 48201 USA.
RP Lyles, RH (reprint author), Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, 1518 Clifton Rd NE, Atlanta, GA 30322 USA.
EM rlyles@sph.emory.edu
FU National Institute of Nursing [1RC4NR012527-01]; National Institute of
Environmental Health Sciences [2R01-ES012458-5]; PHS from the National
Institutes of Health, National Center for Research Resources; Centers
for Disease Control and Prevention [U64/CCU106795, U64/CCU206798,
U64/CCU306802, U64/CCU506831]
FX Supported by National Institute of Nursing Research Grant
1RC4NR012527-01, by National Institute of Environmental Health Sciences
Grant 2R01-ES012458-5, and by PHS Grant UL1 RR025008 from the Clinical
and Translational Science Award Program, National Institutes of Health,
National Center for Research Resources. The HER Study was supported by
the Centers for Disease Control and Prevention: U64/CCU106795,
U64/CCU206798, U64/CCU306802, and U64/CCU506831.
NR 41
TC 18
Z9 18
U1 1
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
J9 EPIDEMIOLOGY
JI Epidemiology
PD JUL
PY 2011
VL 22
IS 4
BP 589
EP 598
DI 10.1097/EDE.0b013e3182117c85
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 772RJ
UT WOS:000291252100026
PM 21487295
ER
PT J
AU Heyer, N
Morata, TC
Pinkerton, LE
Brueck, SE
Stancescu, D
Panaccio, MP
Kim, H
Sinclair, JS
Waters, MA
Estill, CF
Franks, JR
AF Heyer, Nicholas
Morata, Thais C.
Pinkerton, Lynne E.
Brueck, Scott E.
Stancescu, Daniel
Panaccio, Mary Prince
Kim, Hyoshin
Sinclair, J. Stephen
Waters, Martha A.
Estill, Cherie F.
Franks, John R.
TI Use of historical data and a novel metric in the evaluation of the
effectiveness of hearing conservation program components
SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID NOISE EXPOSURE; WORKERS; APPLICABILITY; PREVENTION; PROTECTION; TIME
AB Objectives To evaluate the effectiveness of hearing conservation programs (HCP) and their specific components in reducing noise-induced hearing loss (NIHL).
Methods This retrospective cohort study was conducted at one food-processing plant and two automotive plants. Audiometric and work-history databases were combined with historical noise monitoring data to develop a time-dependent exposure matrix for each plant. Historical changes in production and HCP implementation were collected from company records, employee interviews and focus groups. These data were used to develop time-dependent quality assessments for various HCP components. 5478 male (30 427 observations) and 1005 female (5816 observations) subjects were included in the analysis.
Results Analyses were conducted separately for males and females. Females tended to have less NIHL at given exposure levels than males. Duration of noise exposure stratified by intensity (dBA) was a better predictor of NIHL than the standard equivalent continuous noise level (L-eq) based upon a 3-dBA exchange. Within this cohort, efficient dBA strata for males were < 95 versus >= 95, and for females < 90 versus >= 90. The reported enforced use of hearing protection devices (HPDs) significantly reduced NIHL. The data did not have sufficient within-plant variation to determine the effectiveness of noise monitoring or worker training. An association between increased audiometric testing and NIHL was believed to be an artifact of increased participation in screening.
Conclusions Historical audiometric data combined with noise monitoring data can be used to better understand the effectiveness of HCPs. Regular collection and maintenance of quality data should be encouraged and used to monitor the effectiveness of these interventions.
C1 [Heyer, Nicholas; Kim, Hyoshin] Battelle CPHRE, Seattle, WA 98109 USA.
[Morata, Thais C.; Franks, John R.] NIOSH, DART, Cincinnati, OH 45226 USA.
[Pinkerton, Lynne E.; Brueck, Scott E.; Stancescu, Daniel; Panaccio, Mary Prince; Waters, Martha A.; Estill, Cherie F.] NIOSH, DSHEFS, Cincinnati, OH 45226 USA.
[Sinclair, J. Stephen] Calif State Univ Northridge, Dept Commun Disorders & Sci, Northridge, CA 91330 USA.
RP Heyer, N (reprint author), Battelle CPHRE, 1100 Dexter Ave N,Suite 400, Seattle, WA 98109 USA.
EM heyern@battelle.org
FU National Institute for Occupational Safety and Health
FX This study was fully paid for by the National Institute for Occupational
Safety and Health.
NR 29
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U1 2
U2 13
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1351-0711
J9 OCCUP ENVIRON MED
JI Occup. Environ. Med.
PD JUL
PY 2011
VL 68
IS 7
BP 510
EP 517
DI 10.1136/oem.2009.053801
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 773KY
UT WOS:000291307400008
PM 21059594
ER
PT J
AU Blair, A
Thomas, K
Coble, J
Sandler, DP
Hines, CJ
Lynch, CF
Knott, C
Purdue, MP
Zahm, SH
Alavanja, MCR
Dosemeci, M
Kamel, F
Hoppin, JA
Freeman, LB
Lubin, JH
AF Blair, Aaron
Thomas, Kent
Coble, Joseph
Sandler, Dale P.
Hines, Cynthia J.
Lynch, Charles F.
Knott, Charles
Purdue, Mark P.
Zahm, Shelia Hoar
Alavanja, Michael C. R.
Dosemeci, Mustafa
Kamel, Freya
Hoppin, Jane A.
Freeman, Laura Beane
Lubin, Jay H.
TI Impact of pesticide exposure misclassification on estimates of relative
risks in the Agricultural Health Study
SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID FARM APPLICATORS; CANCER INCIDENCE; RELIABILITY; DISEASE; CHLORPYRIFOS;
INFORMATION; COHORT; WOMEN
AB Background The Agricultural Health Study (AHS) is a prospective study of licensed pesticide applicators and their spouses in Iowa and North Carolina. We evaluate the impact of occupational pesticide exposure misclassification on relative risks using data from the cohort and the AHS Pesticide Exposure Study (AHS/PES).
Methods We assessed the impact of exposure misclassification on relative risks using the range of correlation coefficients observed between measured post-application urinary levels of 2,4-dichlorophenoxyacetic acid (2,4-D) and a chlorpyrifos metabolite and exposure estimates based on an algorithm from 83 AHS pesticide applications.
Results Correlations between urinary levels of 2,4-D and a chlorpyrifos metabolite and algorithm estimated intensity scores were about 0.4 for 2,4-D (n=64), 0.8 for liquid chlorpyrifos (n=4) and 0.6 for granular chlorpyrifos (n=12). Correlations of urinary levels with kilograms of active ingredient used, duration of application, or number of acres treated were lower and ranged from -0.36 to 0.19. These findings indicate that a priori expert-derived algorithm scores were more closely related to measured urinary levels than individual exposure determinants evaluated here. Estimates of potential bias in relative risks based on the correlations from the AHS/PES indicate that non-differential misclassification of exposure using the algorithm would bias estimates towards the null, but less than that from individual exposure determinants.
Conclusions Although correlations between algorithm scores and urinary levels were quite good (ie, correlations between 0.4 and 0.8), exposure misclassification would still bias relative risk estimates in the AHS towards the null and diminish study power.
C1 [Blair, Aaron; Purdue, Mark P.; Zahm, Shelia Hoar; Alavanja, Michael C. R.; Dosemeci, Mustafa; Freeman, Laura Beane; Lubin, Jay H.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Thomas, Kent] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Sandler, Dale P.; Kamel, Freya; Hoppin, Jane A.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA.
[Hines, Cynthia J.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA.
[Lynch, Charles F.] Univ Iowa, Dept Epidemiol, Iowa City, IA USA.
[Knott, Charles] Battelle Inc, Ctr Publ Hlth Res, Res Triangle Pk, NC USA.
[Knott, Charles] Battelle Inc, Ctr Evaluat, Res Triangle Pk, NC USA.
RP Blair, A (reprint author), NCI, Div Canc Epidemiol & Genet, Execut Plaza S,Room 8008, Bethesda, MD 20892 USA.
EM blaira@mail.nih.gov
RI Zahm, Shelia/B-5025-2015; Purdue, Mark/C-9228-2016; Beane Freeman,
Laura/C-4468-2015;
OI Purdue, Mark/0000-0003-1177-3108; Beane Freeman,
Laura/0000-0003-1294-4124; Kamel, Freya/0000-0001-5052-6615; Sandler,
Dale/0000-0002-6776-0018
FU NIH (Division of Cancer Epidemiology and Genetics, National Cancer
Institute) [Z01CP010119]; NIH (National Institute of Environmental
Health Sciences) [Z01-ES049030-1]; U.S. Environmental Protection Agency
[68-D99-011, 68-D99-012, DW-75-93912801-0]
FX This research was partially supported by the Intramural Research Program
of the NIH (Division of Cancer Epidemiology and Genetics, National
Cancer Institute (Z01CP010119) and the National Institute of
Environmental Health Sciences (Z01-ES049030-1)). This work has been
funded in part by the U.S. Environmental Protection Agency under
Contracts 68-D99-011 and 68-D99-012, and through Interagency Agreement
DW-75-93912801-0.
NR 34
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U1 1
U2 15
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1351-0711
J9 OCCUP ENVIRON MED
JI Occup. Environ. Med.
PD JUL
PY 2011
VL 68
IS 7
BP 537
EP 541
DI 10.1136/oem.2010.059469
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 773KY
UT WOS:000291307400012
PM 21257983
ER
PT J
AU Blake, J
Choden, T
Hemans-Henry, C
Koppaka, R
Greene, C
AF Blake, Janice
Choden, Tsering
Hemans-Henry, Calaine
Koppaka, Ram
Greene, Carolyn
TI NYC Epi Scholars Program: Promoting Applied Health Disparities Research
in an Urban Public Health Department-A Program Model
SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE
LA English
DT Article
DE applied epidemiology; epidemiology internship; Epi Scholars;
experiential learning; health disparities research; health status
disparities; nonmedical internship; public health internship; public
health students; teaching health department
AB Objective: Although health disparities research has already contributed to decreased mortality and morbidity in underserved communities, more work is needed. The NYC Epi Scholars program of the New York City Department of Health and Mental Hygiene (NYC DOHMH) aims to address gaps in critical public health needs and to train future public health leaders in epidemiology. The program is designed to increase racial/ethnic and socioeconomic diversity in the public health workforce, to provide fieldwork and practica opportunities, and to cultivate future leaders in epidemiology and public health. Methods: Since its inception in 2007, the NYC Epi Scholars program of the NYC DOHMH has sought talented epidemiology students interested in gaining practical experience in applied health disparities research. NYC Epi Scholars is open to graduate epidemiology students who have demonstrated achievement and leadership potential and gives them an opportunity to provide high-quality research assistance to projects that identify and address health disparities of public health significance. Results: Many of the program's 32 alumni have made notable contributions to public health: publishing articles in peer-reviewed journals; making presentations at national and international conferences; and after graduating, pursuing careers at the DOHMH, Centers for Disease Control and Prevention, the Environmental Protection Agency, and the National Institutes of Health. Conclusions: Because of its noted success, the NYC Epi Scholars program may serve as a "best-practice" model for expansion in other urban health departments.
C1 [Blake, Janice; Choden, Tsering; Hemans-Henry, Calaine] New York City Dept Hlth & Mental Hyg, Bur Publ Hlth Training, New York, NY USA.
[Koppaka, Ram; Greene, Carolyn] New York City Dept Hlth & Mental Hyg, Div Epidemiol, New York, NY USA.
Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Blake, J (reprint author), New York City Dept Hlth & Mental Hyg, Bur Publ Hlth Training, Res Training Program, 42-09 28th St,7th Floor,CN 65, Queens, NY 11101 USA.
EM Jblake2@health.nyc.gov
NR 4
TC 2
Z9 2
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1078-4659
J9 J PUBLIC HEALTH MAN
JI J. Public Health Manag. Pract.
PD JUL-AUG
PY 2011
VL 17
IS 4
BP 313
EP 315
DI 10.1097/PHH.0b013e3182140c00
PG 3
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 769NK
UT WOS:000291022300008
PM 21617405
ER
PT J
AU Sullivent, EE
Faul, M
Wald, MM
AF Sullivent, Ernest E.
Faul, Mark
Wald, Marlena M.
TI Reduced Mortality in Injured Adults Transported by Helicopter Emergency
Medical Services
SO PREHOSPITAL EMERGENCY CARE
LA English
DT Article
DE helicopter; mortality; National Trauma Data Bank; severity; transport
ID TRAUMA SYSTEM; SEVERITY SCORE; SCENE; CARE; IMPACT; OUTCOMES; AIR;
PATTERNS; SURVIVAL; PATIENT
AB Background. Some studies have shown improved outcomes with helicopter emergency medical services (HEMS) transport, while others have not. Safety concerns and cost have prompted reevaluation of the widespread use of HEMS. Objective. To determine whether the mode of transport of trauma patients affects mortality. Methods. Data for 56,744 injured adults aged >= a parts per thousand yen18 years transported to 62 U.S. trauma centers by helicopter or ground ambulance were obtained from the National Sample Program of the 2007 National Trauma Data Bank. In-hospital mortality was calculated for different demographic and injury severity groups. Adjusted odds ratios (AOR) were produced by utilizing a logistic regression model measuring the association of mortality and type of transport, controlling for age, gender, and injury severity (Injury Severity Score [[ISS]] and Revised Trauma Score [[RTS]]). Results. The odds of death were 39%% lower in those transported by HEMS compared with those transported by ground ambulance (AOR == 0.61, 95%% confidence interval [[CI]] == 0.54--0.69). Among those aged >= a parts per thousand yen55 years, the odds of death were not significantly different (AOR == 0.92, 95%% CI == 0.74--1.13). Among all transports, male patients had a higher odds of death (AOR == 1.23, 95%% CI == 1.10--1.38) than female patients. The odds of death increased with each year of age (AOR == 1.040, 95%% CI == 1.037--1.043) and each unit of ISS (AOR == 1.080, 95%% CI == 1.075--1.084), and decreased with each unit of RTS (AOR == 0.46, 95%% CI == 0.45--0.48). Conclusion. The use of HEMS for the transport of adult trauma patients was associated with reduced mortality for patients aged 18--54 years. In this study, HEMS did not improve mortality in adults aged >= a parts per thousand yen55 years. Identification of additional variables in the selection of those patients who will benefit from HEMS transport is expected to enhance this reduction in mortality.
C1 [Sullivent, Ernest E.; Faul, Mark] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA.
RP Faul, M (reprint author), Ctr Dis Control & Prevent, Natl Ctr Injury Prevent, 4770 Buford Highway, Atlanta, GA 30341 USA.
EM mfaul@cdc.gov
NR 54
TC 39
Z9 41
U1 0
U2 7
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1090-3127
J9 PREHOSP EMERG CARE
JI Prehosp. Emerg. Care
PD JUL-SEP
PY 2011
VL 15
IS 3
BP 295
EP 302
DI 10.3109/10903127.2011.569849
PG 8
WC Emergency Medicine; Public, Environmental & Occupational Health
SC Emergency Medicine; Public, Environmental & Occupational Health
GA 768VX
UT WOS:000290967800001
PM 21524205
ER
PT J
AU Tak, S
Buchholz, B
Punnett, L
Moir, S
Paquet, V
Fulmer, S
Marucci-Wellman, H
Wegman, D
AF Tak, SangWoo
Buchholz, Bryan
Punnett, Laura
Moir, Susan
Paquet, Victor
Fulmer, Scott
Marucci-Wellman, Helen
Wegman, David
TI Physical ergonomic hazards in highway tunnel construction: Overview from
the Construction Occupational Health Program
SO APPLIED ERGONOMICS
LA English
DT Article
DE PATH; Trade; Operation; Postural load; Highway tunnel construction
ID LOW-BACK-PAIN; COMPUTERIZED OWAS METHOD; RISK-FACTORS; MUSCULOSKELETAL
DISORDERS; WORKING POSTURES; KNEE; WORKERS; EXPOSURE; IRONWORKERS;
PREVALENCE
AB This report provides an overview of physical ergonomic exposures in highway construction work across trades and major operations. For each operation, the observational method "PATH" (Posture, Activity, Tools and Handling) was used to estimate the percentage of time that workers spent in specific tasks and with exposure to awkward postures and load handling. The observations were carried out on 73 different days, typically for about 4 Is per day, covering 120 construction workers in 5 different trades: laborers, carpenters, ironworkers, plasterers, and tilers. Non-neutral trunk postures (forward or sideways flexion or twisting) were frequently observed, representing over 40% of observations for all trades except laborers (28%). Kneeling and squatting were common in all operations, especially tiling and underground utility relocation work. Handling loads was frequent, especially for plasterers and tilers, with a range of load weights but most often under 15 pounds. The results of this study provide quantitative evidence that workers in highway tunnel construction operations are exposed to ergonomic factors known to present significant health hazards. Numerous opportunities exist for the development and implementation of ergonomic interventions to protect the health and safety of construction workers. (C) 2010 Elsevier Ltd and The Ergonomics Society. All rights reserved.
C1 [Tak, SangWoo; Buchholz, Bryan; Punnett, Laura; Moir, Susan; Paquet, Victor; Fulmer, Scott; Marucci-Wellman, Helen; Wegman, David] Univ Massachusetts, Dept Work Environm, Lowell, MA 01854 USA.
[Moir, Susan] Univ Massachusetts, Boston, MA 02125 USA.
[Paquet, Victor] SUNY Buffalo, Buffalo, NY 14260 USA.
[Marucci-Wellman, Helen] Liberty Mutual Res Inst, Hopkinton, MA 01748 USA.
RP Tak, S (reprint author), NIOSH, 4676 Columbia Pkwy,R-17, Cincinnati, OH 45226 USA.
EM STak@cdc.gov
RI Agaliotis, Maria/G-5334-2012
FU National Institute for Occupational Safety and Health (NIOSH)
[U02/CCU308771, U02/CCU312014, U02/CCU317202]
FX The Center to Protect Workers' Rights (CPWR) supported this research
with grants provided by the National Institute for Occupational Safety
and Health (NIOSH) (grants #U02/CCU308771, U02/CCU312014, and
U02/CCU317202). Its contents are solely the responsibility of the
authors and do not necessarily represent the official views of NIOSH or
CPWR. The authors are grateful for the cooperation of many construction
workers who answered our questions and permitted us to observe their
daily work. The data tables with detailed information will be shared
upon request from any interested readers.
NR 33
TC 11
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U1 5
U2 23
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0003-6870
J9 APPL ERGON
JI Appl. Ergon.
PD JUL
PY 2011
VL 42
IS 5
BP 665
EP 671
DI 10.1016/j.apergo.2010.10.001
PG 7
WC Engineering, Industrial; Ergonomics; Psychology, Applied
SC Engineering; Psychology
GA 758VJ
UT WOS:000290194900005
PM 21112043
ER
PT J
AU Wu, FT
Banyai, K
Huang, JC
Wu, HS
Chang, FY
Yang, JY
Hsiung, CA
Huang, YC
Lin, JS
Hwang, KP
Jiang, BM
Gentsch, JR
AF Wu, Fang-Tzy
Banyai, Krisztian
Huang, Jason C.
Wu, Ho-Sheng
Chang, Feng-Yee
Yang, Jyh-Yuan
Hsiung, Chao Agnes
Huang, Yhu-Chering
Lin, Jen-Shiou
Hwang, Kao-Pin
Jiang, Baoming
Gentsch, Jon R.
TI Diverse Origin of P[19] Rotaviruses in Children With Acute Diarrhea in
Taiwan: Detection of Novel Lineages of the G3, G5, and G9 VP7 Genes
SO JOURNAL OF MEDICAL VIROLOGY
LA English
DT Article
DE phylogenetic analysis; VP7; VP4; VP6; NSP4
ID GROUP-A ROTAVIRUSES; MOLECULAR CHARACTERIZATION; INTERSPECIES
TRANSMISSION; SEQUENCE-ANALYSIS; ACUTE GASTROENTERITIS; PORCINE
ROTAVIRUS; STRAINS; SEROTYPE; NSP4; CLASSIFICATION
AB We previously reported the detection of genotype P[19] rotavirus strains from children hospitalized with acute dehydrating diarrhea during a 5-year surveillance period in Taiwan. The characterization of five P[19] strains (0.4% of all typed), including three G3P[19], a novel G5P[19], and a unique G9P[19] genotype is described in this study. Phylogenetic analysis of the VP4, VP7, VP6, and NSP4 genes was performed, which demonstrated novel lineages for respective genotypes of the VP4 and the VP7 genes. The sequence similarities of the P[19] VP4 gene among Taiwanese human strains was higher (nt, 91.5-96.2%; aa, 93.7-97.6%) than to other P[19] strains (nt, 83.5-86.6%; aa, 89.4-94.1%) from different regions of the world. The VP7 gene of the three G3P[19] Taiwanese strains shared up to 93.4% nt and 97.5% aa identity to each other but had lower similarity to reference strain sequences available in GenBank (nt, <90.1%; aa, <95.6%). Similarly, the VP7 gene of the novel G5P[19] strain was only moderately related to the VP7 gene of reference G5 strains (nt, 82.2-87.3%; aa, 87.0-93.1%), while the VP7 gene of the single G9P[19] strain was genetically distinct from other known human and animal G9 rotavirus strains (nt, <= 92.0%; aa, <= 95.7%). Together, these findings suggest that the Taiwanese P[19] strains originated by independent interspecies transmission events. Synchronized surveillance of human and animal rotaviruses in Taiwan should identify possible hosts of these uncommon human rotavirus strains. J. Med. Virol. 83:1279-1287, 2011. (C) 2011 Wiley-Liss, Inc.
C1 [Wu, Ho-Sheng] Ctr Dis Control, Dept Hlth, Res & Diagnost Ctr, Taipei, Taiwan.
[Wu, Fang-Tzy; Huang, Jason C.] Natl Yang Ming Univ, Lab Sci Med, Dept Biotechnol, Taipei 112, Taiwan.
[Banyai, Krisztian] Hungarian Acad Sci, Vet Med Res Inst, H-1581 Budapest, Hungary.
[Wu, Ho-Sheng] Taipei Med Univ, Sch Med Lab Sci & Biotechnol, Taipei, Taiwan.
[Hsiung, Chao Agnes] Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Taiwan.
[Huang, Yhu-Chering] Chang Gung Univ, Coll Med, Div Pediat Infect Dis, Chang Gung Childrens Hosp, Tao Yuan, Taiwan.
[Lin, Jen-Shiou] Changhua Christian Hosp, Dept Lab Med, Div Pediat Infect Dis, Changhua, Taiwan.
[Hwang, Kao-Pin] Chang Gung Univ, Coll Med, Kaohsiung Med Ctr,Dept Pediat, Div Pediat Infect Dis,Chang Gung Mem Hosp, Kaohsiung, Taiwan.
[Hwang, Kao-Pin] China Med Univ & Hosp, Childrens Hosp, Sch Med, Taichung, Taiwan.
[Jiang, Baoming; Gentsch, Jon R.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA.
RP Wu, HS (reprint author), Ctr Dis Control, Dept Hlth, Res & Diagnost Ctr, Taipei, Taiwan.
EM wuhs@cdc.gov.tw
RI Hsiung, Chao Agnes/E-3994-2010;
OI Banyai, Krisztian/0000-0002-6270-1772
FU Centers for Disease Control, Taiwan [DOH97-DC-11102]; National Research
Program for Genome Medicine [94-0324-19-F-01-00-00,
95-0324-19-F01-00-00-00-35, 96-0324-01-F-01]; Hungarian Research Fund
[PD76364, OTKA]
FX Grant sponsor: Centers for Disease Control, Taiwan; Grant number:
DOH97-DC-11102; Grant sponsor: National Research Program for Genome
Medicine; Grant numbers: 94-0324-19-F-01-00-00;
95-0324-19-F01-00-00-00-35; 96-0324-01-F-01 (partial support); Grant
sponsor: Hungarian Research Fund (to K. B.); Grant number: OTKA,
PD76364.
NR 52
TC 21
Z9 21
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0146-6615
J9 J MED VIROL
JI J. Med. Virol.
PD JUL
PY 2011
VL 83
IS 7
BP 1279
EP 1287
DI 10.1002/jmv.22052
PG 9
WC Virology
SC Virology
GA 763VV
UT WOS:000290588700023
PM 21567431
ER
PT J
AU Grant, L
Esona, M
Gentsch, J
Watt, J
Reid, R
Weatherholtz, R
Santosham, M
Parashar, U
O'Brien, K
AF Grant, Lindsay
Esona, Mathew
Gentsch, Jon
Watt, James
Reid, Raymond
Weatherholtz, Robert
Santosham, Mathuram
Parashar, Umesh
O'Brien, Katherine
TI Detection of G3P[3] and G3P[9] Rotavirus Strains in American Indian
Children With Evidence of Gene Reassortment Between Human and Animal
Rotaviruses
SO JOURNAL OF MEDICAL VIROLOGY
LA English
DT Article
DE G3P[3] genotype; G3P[9] genotype; cat rotavirus; dog rotavirus;
rotavirus vaccine; American Indian
ID GROUP-A ROTAVIRUS; RNA-RNA HYBRIDIZATION; UNITED-STATES; MOLECULAR
CHARACTERIZATION; CANINE ROTAVIRUS; RISK-FACTORS; INTERSPECIES
TRANSMISSIONS; MONOCLONAL-ANTIBODIES; ACUTE GASTROENTERITIS;
NUCLEOTIDE-SEQUENCE
AB The distribution and evolution of human rotavirus strains is important for vaccine development and effectiveness. In settings where rotavirus vaccine coverage is high, vaccine pressure could select for replacement of common strains (similar to those included in rotavirus vaccines) with uncommon strains, some of which could be generated by reassortment between human and animal rotaviruses. Between 2002 and 2004, a phase-III rotavirus vaccine clinical trial was conducted among American Indian children of the Navajo and White Mountain Apache tribes, which are known to be at high risk for rotavirus diarrhea. We evaluated the rotavirus strains collected from study participants who received placebo during the trial to determine the distribution of rotavirus genotypes and to detect emerging strains that contribute to disease and could influence rotavirus vaccine effectiveness. Three uncommon strains of human rotavirus, two G3P[3] and one G3P[9] strains were detected in stools of children aged 3 to 6 months of age. Segments of all 11 rotavirus genes were sequenced and genotyped by comparison of cognate gene fragments with reference strains. The G3P[3] strains had similar genotypes to each other and to reference dog and cat strains. The G3P[9] strain had similar genotypes to cow, cat and dog reference strains. Genetic analyses of these three strains support the known diversity generating mechanisms of rotavirus. J. Med. Virol. 83:12881299, 2011. (C) 2011 Wiley-Liss, Inc.
C1 [Grant, Lindsay; Watt, James; Reid, Raymond; Weatherholtz, Robert; Santosham, Mathuram; O'Brien, Katherine] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Ctr Amer Indian Hlth, Baltimore, MD 21205 USA.
[Esona, Mathew; Gentsch, Jon; Parashar, Umesh] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Grant, L (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Ctr Amer Indian Hlth, 621 N Washington St, Baltimore, MD 21205 USA.
EM lgrant@jhsph.edu
NR 76
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Z9 22
U1 1
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0146-6615
J9 J MED VIROL
JI J. Med. Virol.
PD JUL
PY 2011
VL 83
IS 7
BP 1288
EP 1299
DI 10.1002/jmv.22076
PG 12
WC Virology
SC Virology
GA 763VV
UT WOS:000290588700024
PM 21567432
ER
PT J
AU Zhong, WM
He, J
Tang, XL
Liu, F
Lu, XH
Zeng, H
Vafai, A
Fu, TM
Katz, JM
Hancock, K
AF Zhong, Weimin
He, Ju
Tang, Xiaoling
Liu, Feng
Lu, Xiuhua
Zeng, Hui
Vafai, Abbas
Fu, Tong-Ming
Katz, Jacqueline M.
Hancock, Kathy
TI Development and evaluation of an M2-293FT cell-based flow cytometric
assay for quantification of antibody response to native form of matrix
protein 2 of influenza A viruses
SO JOURNAL OF IMMUNOLOGICAL METHODS
LA English
DT Article
DE Influenza A virus; Matrix protein 2; Gene transfection; Antibody
response; Flow cytometry; Immune protection
ID INTEGRAL MEMBRANE-PROTEIN; M2 PROTEIN; MONOCLONAL-ANTIBODY; CONJUGATE
VACCINES; CHANNEL; MICE; PROTECTION; ECTODOMAIN; REPLICATION;
VACCINATION
AB Matrix protein 2 (M2) of influenza A viruses is an attractive target for the development of broadly cross-protective influenza vaccines and therapeutic antibodies. The available evidence suggests that antibodies reactive to the natural tetrameric form of M2 proteins, rather than those to synthetic peptides of M2 ectodomain (M2e), best correlate with M2-mediated immune protection. However, the current ability to quantify strain-specific and/or subtype-cross-reactive M2 antibodies against the natural form of M2 antigens from influenza A viruses of different host origin is limited. In the present study, we generated a panel of 293FT transfected cell lines stably expressing full-length tetrameric forms of M2 molecules from human, avian and the swine-origin 2009 pandemic H1N1 influenza A virus, respectively, and developed an M2-293FT cell line-based flow cytometric assay (M2-FCA). Side-by-side comparison of M2-FCA with a synthetic M2e peptide-based indirect ELISA (M2e-ELISA) reveals that M2-FCA is highly efficient in quantifying both M2e sequence-specific and cross-reactive antibodies to the native form of M2 antigens. In contrast, promiscuity was evident when specificity and cross-reactivity of anti-M2 antibodies were assessed by M2e-ELISA. These results demonstrate that M2-FCA represents a rapid, simple and sensitive method to quantitatively assess specificity and cross-reactivity of anti-M2 antibodies after infection or vaccination. Published by Elsevier B.V.
C1 [Zhong, Weimin; Liu, Feng; Lu, Xiuhua; Zeng, Hui; Katz, Jacqueline M.; Hancock, Kathy] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[He, Ju; Tang, Xiaoling; Vafai, Abbas] Ctr Dis Control & Prevent, Div Sci Resources, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
[Fu, Tong-Ming] Merck Res Labs, Dept Vaccine Basic Res, West Point, PA 19486 USA.
RP Zhong, WM (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd, Atlanta, GA 30333 USA.
EM wzhong@cdc.gov
FU Centers for Disease Control and Prevention
FX This study was funded by the Centers for Disease Control and Prevention.
The funder has no role in study design, data collection and analysis,
decision to publish, and preparation of the manuscript.
NR 26
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U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1759
J9 J IMMUNOL METHODS
JI J. Immunol. Methods
PD JUN 30
PY 2011
VL 369
IS 1-2
BP 115
EP 124
DI 10.1016/j.jim.2011.04.010
PG 10
WC Biochemical Research Methods; Immunology
SC Biochemistry & Molecular Biology; Immunology
GA 793CW
UT WOS:000292799000013
PM 21570401
ER
PT J
AU Nazemalhosseini-Mojarad, E
Haghighi, A
Taghipour, N
Keshavarz, A
Mohebi, SR
Zali, MR
Xiao, LH
AF Nazemalhosseini-Mojarad, Ehsan
Haghighi, Ali
Taghipour, Niloofar
Keshavarz, Akbar
Mohebi, Seyed Reza
Zali, Mohammad Reza
Xiao, Lihua
TI Subtype analysis of Cryptosporidium parvum and Cryptosporidium hominis
isolates from humans and cattle in Iran
SO VETERINARY PARASITOLOGY
LA English
DT Article
DE Cryptosporidium; Bovine; Human; gp60; Subtype
ID NORTHERN-IRELAND; DAIRY CALVES; CHILDREN; SPP.; DIVERSITY; GENOTYPES;
ANIMALS
AB Cryptosporidium is an intestinal parasite associated with severe acute diarrhea in humans and animals. To investigate subtypes of Cryptosporidium spp. isolated from humans and cattle in Iran, 47 Cryptosporidium parvum (22 from children and 25 from cattle) and three Cryptosporidium hominis from children were characterized by sequence analysis of the 60 kDa glycoprotein (gp60) gene. Nine subtypes (two of C. hominis and seven of C. parvum) in four subtype families were identified. Cattle were mainly infected with C. parvum IIa subtypes and humans mostly with the C parvum Ha and lid subtypes. Consequently, cattle could be a source of human infection with C parvum IIa in Iran. However, the occurrence of subtype lid families in Iranian children, suggests that other infection sources might also be involved in C parvum transmission. To our knowledge, this is the first published record and description of Cryptosporidium subtypes in Iran. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Haghighi, Ali; Taghipour, Niloofar; Keshavarz, Akbar] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Parasitol & Mycol, Tehran, Iran.
[Nazemalhosseini-Mojarad, Ehsan; Mohebi, Seyed Reza; Zali, Mohammad Reza] Shahid Beheshti Univ Med Sci, Res Ctr Gastroenterol & Liver Dis, Tehran, Iran.
[Xiao, Lihua] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Publ Hlth Serv, Atlanta, GA USA.
RP Haghighi, A (reprint author), Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Parasitol & Mycol, Tehran, Iran.
EM a_haghighi@sbmu.ac.ir
RI Xiao, Lihua/B-1704-2013
OI Xiao, Lihua/0000-0001-8532-2727
FU Research Center of Gastroenterology and Liver Diseases, Shahid Beheshti
University of Medical Sciences, Iran [459]
FX This work was supported by the Research Center of Gastroenterology and
Liver Diseases, Shahid Beheshti University of Medical Sciences, Iran
(grant number 459). Thanks are due to The Lucidus Consultancy, for
providing useful suggestions and help with the English.
NR 20
TC 22
Z9 22
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-4017
J9 VET PARASITOL
JI Vet. Parasitol.
PD JUN 30
PY 2011
VL 179
IS 1-3
BP 250
EP 252
DI 10.1016/j.vetpar.2011.01.051
PG 3
WC Parasitology; Veterinary Sciences
SC Parasitology; Veterinary Sciences
GA 787BZ
UT WOS:000292352900040
PM 21376469
ER
PT J
AU Bern, C
AF Bern, Caryn
TI Antitrypanosomal Therapy for Chronic Chagas' Disease
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID TRYPANOSOMA-CRUZI INFECTION; POLYMERASE-CHAIN-REACTION; HEART-DISEASE;
ETIOLOGIC TREATMENT; AMERICAN TRYPANOSOMIASIS; UNITED-STATES;
BENZNIDAZOLE; TRIAL; CHEMOTHERAPY; NIFURTIMOX
AB A 42-year-old woman presents to her physician with a letter stating that after she made a recent blood donation, a serologic test of her donated blood was positive for Chagas' disease. The patient was born in El Salvador and moved to the United States when she was 18 years of age. Her three children are 8, 13, and 16 years of age. Her medical history is remarkable only for a cholecystectomy 2 years earlier; she reports no cardiac or gastrointestinal symptoms. Her physical examination is unremarkable. Electrocardiography (ECG) shows sinus rhythm at a rate of 72 beats per minute and a complete right bundle-branch block. An echocardiogram shows mild left ventricular segmental wall-motion abnormalities, but a normal ejection fraction and left ventricular diameter. The patient is referred to an infectious-disease consultant, who recommends antitrypanosomal therapy.
C1 Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA.
RP Bern, C (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, 1600 Clifton Rd, Atlanta, GA 30333 USA.
EM cxb9@cdc.gov
NR 53
TC 106
Z9 108
U1 3
U2 13
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD JUN 30
PY 2011
VL 364
IS 26
BP 2527
EP 2534
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA 785AM
UT WOS:000292199800008
PM 21714649
ER
PT J
AU Reefhuis, J
Rasmussen, SA
Honein, MA
AF Reefhuis, Jennita
Rasmussen, Sonja A.
Honein, Margaret A.
TI Prenatal versus Postnatal Repair of Myelomeningocele
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
ID BIRTH-DEFECTS
C1 [Reefhuis, Jennita; Rasmussen, Sonja A.; Honein, Margaret A.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Reefhuis, J (reprint author), Ctr Dis Control & Prevent, Atlanta, GA USA.
EM nzr5@cdc.gov
NR 3
TC 2
Z9 2
U1 0
U2 2
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD JUN 30
PY 2011
VL 364
IS 26
BP 2555
EP 2555
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 785AM
UT WOS:000292199800022
PM 21714660
ER
PT J
AU Frank, KM
Schneewind, O
Shieh, WJ
AF Frank, Karen M.
Schneewind, Olaf
Shieh, Wun-Ju
TI Investigation of a Researcher's Death Due to Septicemic Plague
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
ID PESTIS
C1 [Frank, Karen M.; Schneewind, Olaf] Univ Chicago, Chicago, IL 60637 USA.
[Shieh, Wun-Ju] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Frank, KM (reprint author), Univ Chicago, Chicago, IL 60637 USA.
EM kfrank@uchicago.edu
FU NIAID NIH HHS [1-U54-AI057153]
NR 4
TC 22
Z9 23
U1 0
U2 1
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD JUN 30
PY 2011
VL 364
IS 26
BP 2563
EP 2564
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 785AM
UT WOS:000292199800035
PM 21714673
ER
PT J
AU Kim, C
Ahmed, JA
Eidex, RB
Nyoka, R
Waiboci, LW
Erdman, D
Tepo, A
Mahamud, AS
Kabura, W
Nguhi, M
Muthoka, P
Burton, W
Breiman, RF
Njenga, MK
Katz, MA
AF Kim, Curi
Ahmed, Jamal A.
Eidex, Rachel B.
Nyoka, Raymond
Waiboci, Lilian W.
Erdman, Dean
Tepo, Adan
Mahamud, Abdirahman S.
Kabura, Wamburu
Nguhi, Margaret
Muthoka, Philip
Burton, Wagacha
Breiman, Robert F.
Njenga, M. Kariuki
Katz, Mark A.
TI Comparison of Nasopharyngeal and Oropharyngeal Swabs for the Diagnosis
of Eight Respiratory Viruses by Real-Time Reverse Transcription-PCR
Assays
SO PLOS ONE
LA English
DT Article
ID POLYMERASE-CHAIN-REACTION; CHILDREN; INFECTIONS; SPECIMENS; H5N1
AB Background: Many acute respiratory illness surveillance systems collect and test nasopharyngeal (NP) and/or oropharyngeal (OP) swab specimens, yet there are few studies assessing the relative measures of performance for NP versus OP specimens.
Methods: We collected paired NP and OP swabs separately from pediatric and adult patients with influenza-like illness or severe acute respiratory illness at two respiratory surveillance sites in Kenya. The specimens were tested for eight respiratory viruses by real-time reverse transcription-polymerase chain reaction (qRT-PCR). Positivity for a specific virus was defined as detection of viral nucleic acid in either swab.
Results: Of 2,331 paired NP/OP specimens, 1,402 (60.1%) were positive for at least one virus, and 393 (16.9%) were positive for more than one virus. Overall, OP swabs were significantly more sensitive than NP swabs for adenovirus (72.4% vs. 57.6%, p < 0.01) and 2009 pandemic influenza A (H1N1) virus (91.2% vs. 70.4%, p < 0.01). NP specimens were more sensitive for influenza B virus (83.3% vs. 61.5%, p = 0.02), parainfluenza virus 2 (85.7%, vs. 39.3%, p < 0.01), and parainfluenza virus 3 (83.9% vs. 67.4%, p < 0.01). The two methods did not differ significantly for human metapneumovirus, influenza A (H3N2) virus, parainfluenza virus 1, or respiratory syncytial virus.
Conclusions: The sensitivities were variable among the eight viruses tested; neither specimen was consistently more effective than the other. For respiratory disease surveillance programs using qRT-PCR that aim to maximize sensitivity for a large number of viruses, collecting combined NP and OP specimens would be the most effective approach.
C1 [Kim, Curi; Erdman, Dean] US Ctr Dis Control & Prevent, Atlanta, GA USA.
[Ahmed, Jamal A.; Eidex, Rachel B.; Nyoka, Raymond; Waiboci, Lilian W.; Tepo, Adan; Mahamud, Abdirahman S.; Breiman, Robert F.; Njenga, M. Kariuki; Katz, Mark A.] Ctr Dis Control & Prevent Kenya, Nairobi, Kenya.
[Kabura, Wamburu] Kenya Govt Med Res Ctr, Nairobi, Kenya.
[Nguhi, Margaret] Int Rescue Comm, Nairobi, Kenya.
[Muthoka, Philip] Minist Publ Hlth & Sanitat, Nairobi, Kenya.
[Burton, Wagacha] United Nations High Commissioner Refugees, Nairobi, Kenya.
RP Kim, C (reprint author), US Ctr Dis Control & Prevent, Atlanta, GA USA.
EM mkatz@ke.cdc.gov
NR 25
TC 35
Z9 37
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 30
PY 2011
VL 6
IS 6
AR e21610
DI 10.1371/journal.pone.0021610
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 786GP
UT WOS:000292291800026
PM 21738731
ER
PT J
AU Ayisi, JG
van't Hoog, AH
Agaya, JA
Mchembere, W
Nyamthimba, PO
Muhenje, O
Marston, BJ
AF Ayisi, John G.
van't Hoog, Anna H.
Agaya, Janet A.
Mchembere, Walter
Nyamthimba, Peter O.
Muhenje, Odylia
Marston, Barbara J.
TI Care seeking and attitudes towards treatment compliance by newly
enrolled tuberculosis patients in the district treatment programme in
rural western Kenya: a qualitative study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE health-seeking; tuberculosis; diagnosis; delay; qualitative
ID HEALTH-SEEKING; BEHAVIOR; PERCEPTIONS; MORBIDITY; MORTALITY; ETHIOPIA;
BARRIERS; HIV
AB Background: The two issues mostly affecting the success of tuberculosis (TB) control programmes are delay in presentation and non-adherence to treatment. It is important to understand the factors that contribute to these issues, particularly in resource limited settings, where rates of tuberculosis are high. The objective of this study is to assess health-seeking behaviour and health care experiences among persons with pulmonary tuberculosis, and identify the reasons patients might not complete their treatment.
Methods: We performed qualitative one-on-one in-depth interviews with pulmonary tuberculosis patients in nine health facilities in rural western Kenya. Thirty-one patients, 18 women and 13 men, participated in the study. All reside in an area of western Kenya with a Health and Demographic Surveillance System (HDSS). They had attended treatment for up to 4 weeks on scheduled TB clinic days in September and October 2005. The nine sites all provide diagnostic and treatment services. Eight of the facilities were public (3 hospitals and 5 health centres) and one was a mission health centre.
Results: Most patients initially self-treated with herbal remedies or drugs purchased from kiosks or pharmacies before seeking professional care. The reported time from initial symptoms to TB diagnosis ranged from 3 weeks to 9 years. Misinterpretation of early symptoms and financial constraints were the most common reasons reported for the delay. We also explored potential reasons that patients might discontinue their treatment before completing it. Reasons included being unaware of the duration of TB treatment, stopping treatment once symptoms subsided, and lack of family support.
Conclusions: This qualitative study highlighted important challenges to TB control in rural western Kenya, and provided useful information that was further validated in a quantitative study in the same area.
C1 [Ayisi, John G.] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu 40100, Kenya.
[Ayisi, John G.] Minist Higher Educ Sci & Technol, Directorate Res Management & Dev, Nairobi 00100, Kenya.
[van't Hoog, Anna H.; Agaya, Janet A.; Mchembere, Walter; Nyamthimba, Peter O.] Kenya Govt Med Res Ctr, KEMRI CDC Res & Collaborat Programme, Kisumu 40100, Kenya.
[van't Hoog, Anna H.] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol KEBB, NL-1100 DD Amsterdam, Netherlands.
[Muhenje, Odylia] US Ctr Dis Control & Prevent, Global AIDS Programme, Nairobi 00200, Kenya.
[Marston, Barbara J.] Ctr Dis Control & Prevent, Global AIDS Programme, Atlanta, GA 30333 USA.
RP Ayisi, JG (reprint author), Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu Maseno Rd,POB 1578, Kisumu 40100, Kenya.
EM john.ayisi@yahoo.com
FU PEPFAR/Global AIDS Programme through CDC
FX We gratefully acknowledge all hospital health staff and their respective
administrations for their valuable cooperation, the study interviewers
and the TB patients for their participation; PEPFAR/Global AIDS
Programme through CDC for supporting the study; MW Borgdorff and KF
Laserson for their valuable comments on the manuscript and Dana Dolan
for copyediting. "The KEMRI/CDC HDSS is a member of the INDEPTH
Network". This study was published with the permission of Director,
KEMRI.
NR 42
TC 13
Z9 13
U1 4
U2 12
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 29
PY 2011
VL 11
AR 515
DI 10.1186/1471-2458-11-515
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 791UO
UT WOS:000292692100001
PM 21714895
ER
PT J
AU Wang, X
Cohn, A
Comanducci, M
Andrew, L
Zhao, X
MacNeil, JR
Schmink, S
Muzzi, A
Bambini, S
Rappuoli, R
Pizza, M
Murphy, E
Hoiseth, SK
Jansen, KU
Anderson, AS
Harrison, LH
Clark, TA
Messonnier, NE
Mayer, LW
AF Wang, Xin
Cohn, Amanda
Comanducci, Maurizio
Andrew, Lubomira
Zhao, Xin
MacNeil, Jessica R.
Schmink, Susanna
Muzzi, Alessandro
Bambini, Stefania
Rappuoli, Rino
Pizza, Mariagrazia
Murphy, Ellen
Hoiseth, Susan K.
Jansen, Kathrin U.
Anderson, Annaliesa S.
Harrison, Lee H.
Clark, Thomas A.
Messonnier, Nancy E.
Mayer, Leonard W.
TI Prevalence and genetic diversity of candidate vaccine antigens among
invasive Neisseria meningitidis isolates in the United States
SO VACCINE
LA English
DT Article
DE Neisseria meningitidis; Serogroup B vaccine; Genetic diversity; Vaccine
antigen
ID FACTOR-H-BINDING; SEROGROUP-B MENINGOCOCCUS; PROTEIN; STRAINS; DISEASE;
NADA; IDENTIFICATION; LIPOPROTEIN; VARIANTS; COVERAGE
AB Neisseria meningitidis (Nm) serogroups B, C and Y are the major causes of meningococcal diseases in the United States. NmB accounts for similar to 1/3 of the disease but no licensed vaccine is yet available. Two candidate vaccines are being developed specifically to target NmB, but may also provide protection against other serogroups. To assess the potential impact of these vaccines on NmB and other serogroups causing disease in the US, we determined the prevalence, genetic diversity and epidemiological characteristics of three candidate antigen genes in Nm isolates collected through Active Bacterial Core surveillance (ABCs), a population-based active surveillance program.fHbp was detected in all NmB. NmY and NmW135 isolates. Eleven NmC isolates contain fHbp with a single base-pair deletion creating a frame shift in the C-terminal region. Among NmB, 59% were FHbp subfamily/variant B/v1 and 41% A/v2-3. Among NmC and NmY, 39% and 3% were B/v1, respectively. nadA was detected in 39% of NmB, 61% of NmC and 4% of NmY. Among isolates tested, nhbA was present in all NmB and 96% of non-B. For the subset of strains sequenced for NadA and NhbA, pairwise identity was greater than 93% and 78%, respectively. The proportion of FHbp subfamily/variant was different between ABCs site and year, but no linear temporal trend was observed. Although assessment of the vaccine coverage also requires understanding of the antigen expression and the ability to induce bactericidal activity, our finding that all isolates contain one or more antigen genes suggests these candidate vaccines may protect against multiple Nm serogroups. Published by Elsevier Ltd.
C1 [Wang, Xin; Cohn, Amanda; Zhao, Xin; MacNeil, Jessica R.; Schmink, Susanna; Clark, Thomas A.; Messonnier, Nancy E.; Mayer, Leonard W.] Ctr Dis Control & Prevent, Meningitis & Vaccine Preventable Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Comanducci, Maurizio; Muzzi, Alessandro; Bambini, Stefania; Rappuoli, Rino; Pizza, Mariagrazia] Novartis Vaccines, Siena, Italy.
[Andrew, Lubomira; Murphy, Ellen; Hoiseth, Susan K.; Jansen, Kathrin U.; Anderson, Annaliesa S.] Pfizer Vaccine Res, Pearl River, NY USA.
[Harrison, Lee H.] Univ Pittsburgh, Sch Med, Infect Dis Epidemiol Res Unit, Pittsburgh, PA USA.
[Harrison, Lee H.] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA.
RP Wang, X (reprint author), Ctr Dis Control & Prevent, Meningitis & Vaccine Preventable Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
EM gqe8@cdc.gov
RI Muzzi, Alessandro/J-6200-2012
FU Centers for Disease Control and Prevention; National Institute of
Allergy and Infectious Diseases; Sanofi Pasteur; Novartis Vaccines;
GlaxoSmithKline; Pfizer; Pfizer Vaccine Research
FX Maurizio Comanducci, Alessandro Muzzi, Stefania Bambini, Rino Rappuoli,
and Mariagrazia Pizza are employees of Novartis Vaccines. Lubomira
Andrew, Ellen Murphy, Susan K. Hoiseth, Kathrin U. Jansen, and Annaliesa
S. Anderson are employees of Pfizer Vaccine Research. Lee Harrison
receives funding from the Centers for Disease Control and Prevention and
the National Institute of Allergy and Infectious Diseases. He receives
research support and lecture fees from Sanofi Pasteur; lecture fees from
Novartis Vaccines; and has served as a consultant to GlaxoSmithKline,
Novartis Vaccines, Sanofi Pasteur, and Pfizer. All other co-authors
declare no conflict of interest. Financial support: CDC received funding
(under Cooperative Research and Development Agreements) from Novartis
Vaccines and Pfizer Vaccine Research for performing sequencing.
NR 34
TC 49
Z9 49
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD JUN 24
PY 2011
VL 29
IS 29-30
BP 4739
EP 4744
DI 10.1016/j.vaccine.2011.04.092
PG 6
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 788VG
UT WOS:000292471900014
PM 21571026
ER
PT J
AU Allen, IC
Moore, CB
Schneider, M
Lei, Y
Davis, BK
Scull, MA
Gris, D
Roney, KE
Zimmermann, AG
Bowzard, JB
Ranjan, P
Monroe, KM
Pickles, RJ
Sambhara, S
Ting, JPY
AF Allen, Irving C.
Moore, Chris B.
Schneider, Monika
Lei, Yu
Davis, Beckley K.
Scull, Margaret A.
Gris, Denis
Roney, Kelly E.
Zimmermann, Albert G.
Bowzard, John B.
Ranjan, Priya
Monroe, Kathryn M.
Pickles, Raymond J.
Sambhara, Suryaprakash
Ting, Jenny P. Y.
TI NLRX1 Protein Attenuates Inflammatory Responses to Infection by
Interfering with the RIG-I-MAVS and TRAF6-NF-kappa B Signaling Pathways
SO IMMUNITY
LA English
DT Article
ID NF-KAPPA-B; ANTIVIRAL IMMUNE-RESPONSES; OXYGEN SPECIES PRODUCTION; RNA
HELICASE LGP2; CUTTING EDGE; ACTIVATION; NLRC5; INHIBITION; APOPTOSIS;
RECEPTOR
AB The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed that Nlrx1(-/-) mice exhibited increased expression of antiviral signaling molecules IFN-beta, STAT2, OAS1, and IL-6 after influenza virus infection. Consistent with increased inflammation, Nlrx1(-/-) mice exhibited marked morbidity and histopathology. Infection of these mice with an influenza strain that carries a mutated NS-1 protein, which normally prevents IFN induction by interaction with RNA and the intracellular RNA sensor RIG-I, further exacerbated IL-6 and type 1 IFN signaling. NLRX1 also weakened cytokine responses to the 2009 H1N1 pandemic influenza virus in human cells. Mechanistically, Nlrx1 deletion led to constitutive interaction of MAVS and RIG-I. Additionally, an inhibitory function is identified for NLRX1 during LPS activation of macrophages where the MAVS-RIG-I pathway was not involved. NLRX1 interacts with TRAF6 and inhibits NF-kappa B activation. Thus, NLRX1 functions as a checkpoint of overzealous inflammation.
C1 [Allen, Irving C.; Davis, Beckley K.; Gris, Denis; Zimmermann, Albert G.; Ting, Jenny P. Y.] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.
[Schneider, Monika; Scull, Margaret A.; Roney, Kelly E.; Pickles, Raymond J.; Ting, Jenny P. Y.] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA.
[Lei, Yu; Ting, Jenny P. Y.] Univ N Carolina, Oral Biol Program, Chapel Hill, NC 27599 USA.
[Moore, Chris B.] GlaxoSmithKline Inc, Infect Dis, Ctr Excellence Drug Discovery, Res Triangle Pk, NC 27709 USA.
[Bowzard, John B.; Ranjan, Priya; Sambhara, Suryaprakash] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA.
[Monroe, Kathryn M.] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA.
RP Ting, JPY (reprint author), Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.
EM jenny_ting@med.unc.edu
FU [U54-AI057157 (SERCEB)]; [U19-AI067798]; [U19-AI077437];
[F32-AI-082895-01]; [T32-AR007416]; [T32-CA009156]
FX The authors would like to thank W.S. Barclay (Imperial College London)
for providing the influenza A/PR/8/34mut39 virus. We would
also like to thank J.M. Katz and N.J. Cox of the Influenza Division for
their support. This work is supported by U54-AI057157 (SERCEB),
U19-AI067798, U19-AI077437 (J.P.Y.T.), F32-AI-082895-01, T32-AR007416,
and T32-CA009156 (I.C.A.).
NR 30
TC 125
Z9 132
U1 0
U2 21
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1074-7613
J9 IMMUNITY
JI Immunity
PD JUN 24
PY 2011
VL 34
IS 6
BP 854
EP 865
DI 10.1016/j.immuni.2011.03.026
PG 12
WC Immunology
SC Immunology
GA 787AT
UT WOS:000292349700007
PM 21703540
ER
PT J
AU Griffiths, UK
Clark, A
Shimanovich, V
Glinskaya, I
Tursunova, D
Kim, L
Mosina, L
Hajjeh, R
Edmond, K
AF Griffiths, Ulla K.
Clark, Andrew
Shimanovich, Veronika
Glinskaya, Irina
Tursunova, Dilorom
Kim, Lucia
Mosina, Liudmila
Hajjeh, Rana
Edmond, Karen
TI Comparative Economic Evaluation of Haemophilus influenzae Type b
Vaccination in Belarus and Uzbekistan
SO PLOS ONE
LA English
DT Article
ID COST-EFFECTIVENESS; DISEASE; EPIDEMIOLOGY; MENINGITIS; CHILDREN;
PNEUMONIA; CONJUGATE; METAANALYSIS; MORTALITY; FRANCE
AB Background: Hib vaccine has gradually been introduced into more and more countries during the past two decades, partly due to GAVI Alliance support to low-income countries. However, since Hib disease burden is difficult to establish in settings with limited diagnostic capacities and since the vaccine continues to be relatively expensive, some Governments remain doubtful about its value leading to concerns about financial sustainability. Similarly, several middle-income countries have not introduced the vaccine. The aim of this study is to estimate and compare the cost-effectiveness of Hib vaccination in a country relying on self-financing (Belarus) and a country eligible for GAVI Alliance support (Uzbekistan).
Methods and Findings: A decision analytic model was used to estimate morbidity and mortality from Hib meningitis, Hib pneumonia and other types of Hib disease with and without the vaccine. Treatment costs were attached to each disease event. Data on disease incidence, case fatality ratios and costs were primarily determined from national sources. For the Belarus 2009 birth cohort, Hib vaccine is estimated to prevent 467 invasive disease cases, 4 cases of meningitis sequelae, and 3 deaths, while in Uzbekistan 3,069 invasive cases, 34 sequelae cases and 341 deaths are prevented. Estimated costs per discounted DALY averted are US$ 9,323 in Belarus and US$ 267 in Uzbekistan.
Conclusion: The primary reason why the cost-effectiveness values are more favourable in Uzbekistan than in Belarus is that relatively more deaths are averted in Uzbekistan due to higher baseline mortality burden. Two other explanations are that the vaccine price is lower in Uzbekistan and that Uzbekistan uses a three dose schedule compared to four doses in Belarus. However, when seen in the context of the relative ability to pay for public health, the vaccine can be considered cost-effective in both countries.
C1 [Griffiths, Ulla K.; Clark, Andrew; Edmond, Karen] London Sch Hyg & Trop Med, Hib Initiat, London WC1, England.
[Shimanovich, Veronika] Republican Ctr Hyg Epidemiol & Publ Hlth, Minsk, Byelarus.
[Glinskaya, Irina] Minsk City Ctr Hyg & Epidemiol, Minsk, Byelarus.
[Tursunova, Dilorom; Kim, Lucia] Minist Hlth, Tashkent, Uzbekistan.
[Mosina, Liudmila] WHO Reg Off Europe, Copenhagen, Denmark.
[Hajjeh, Rana] Ctr Dis Control, Atlanta, GA 30333 USA.
RP Griffiths, UK (reprint author), London Sch Hyg & Trop Med, Hib Initiat, London WC1, England.
EM ulla.griffiths@lshtm.ac.uk
FU Hib Initiative, GAVI Alliance
FX This study was funded by the Hib Initiative, which was a GAVI Alliance
funded project that lasted from 2005-2009. The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 46
TC 8
Z9 8
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 24
PY 2011
VL 6
IS 6
AR e21472
DI 10.1371/journal.pone.0021472
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 782UF
UT WOS:000292036900035
PM 21720546
ER
PT J
AU Li, Q
Hsia, J
Yang, GH
AF Li, Qiang
Hsia, Jason
Yang, Gonghuan
TI Prevalence of Smoking in China in 2010
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
C1 [Li, Qiang; Yang, Gonghuan] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China.
[Hsia, Jason] US Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Li, Q (reprint author), Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China.
EM yangghuan@vip.sina.com
NR 2
TC 188
Z9 208
U1 0
U2 14
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD JUN 23
PY 2011
VL 364
IS 25
BP 2469
EP 2470
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 781MG
UT WOS:000291936100024
PM 21696322
ER
PT J
AU Onofrey, S
Church, D
Kludt, P
DeMaria, A
Cranston, K
Beckett, GA
Holmberg, SD
Ward, JW
Holtzman, D
AF Onofrey, Shauna
Church, Daniel
Kludt, Patricia
DeMaria, Alfred
Cranston, Kevin
Beckett, Geoff A.
Holmberg, Scott D.
Ward, John W.
Holtzman, Deborah
TI Hepatitis C Virus Infection Among Adolescents and Young
Adults-Massachusetts, 2002-2009 (Reprinted from MMWR, vol 60, pg
537-541, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
ID INJECTION-DRUG USERS; UNITED-STATES; PREVALENCE
C1 [Beckett, Geoff A.; Holmberg, Scott D.; Ward, John W.; Holtzman, Deborah] CDC, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
[Onofrey, Shauna; Church, Daniel; Kludt, Patricia; DeMaria, Alfred; Cranston, Kevin] Massachusetts Dept Publ Hlth, Boston, MA 02111 USA.
RP Onofrey, S (reprint author), CDC, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
EM dholtzman@cdc.gov
NR 11
TC 2
Z9 2
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 22
PY 2011
VL 305
IS 24
BP 2511
EP 2513
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 780MF
UT WOS:000291860400009
ER
PT J
AU Zahran, HS
Bailey, C
Garbe, P
AF Zahran, Hatice S.
Bailey, Cathy
Garbe, Paul
TI Vital Signs: Asthma Prevalence, Disease Characteristics, and
Self-Management Education-United States, 2001-2009 (Reprinted from MMWR,
vol 60, pg 547-552, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Zahran, Hatice S.; Bailey, Cathy; Garbe, Paul] CDC, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA.
RP Zahran, HS (reprint author), CDC, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA.
EM hzahran@cdc.gov
NR 1
TC 2
Z9 2
U1 1
U2 5
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 22
PY 2011
VL 305
IS 24
BP 2514
EP 2516
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 780MF
UT WOS:000291860400010
ER
PT J
AU Chen, L
Peek, M
Stokich, D
Todd, R
Anderson, M
Murphy, FK
Hoffman, R
Evans, A
Jordan-Villegas, A
McCracken, G
Chung, WM
Tran, J
Raj, P
Shieh, WJ
Schmitz, A
Zaki, S
Hills, SL
Lambert, A
Panella, A
Laven, J
Kosoy, O
Johnson, BW
Lanciotti, RS
Fischer, M
AF Chen, L.
Peek, M.
Stokich, D.
Todd, R.
Anderson, M.
Murphy, F. K.
Hoffman, R.
Evans, A.
Jordan-Villegas, A.
McCracken, G., Jr.
Chung, W. M.
Tran, J.
Raj, P.
Shieh, W-J
Schmitz, A.
Zaki, S.
Hills, S. L.
Lambert, A.
Panella, A.
Laven, J.
Kosoy, O.
Johnson, B. W.
Lanciotti, R. S.
Fischer, M.
TI Japanese Encephalitis in Two Children-United States, 2010 (Reprinted
from MMWR, vol 60, pg 276-278, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
ID NEUROCYSTICERCOSIS; CYSTICERCOSIS; TRAVELERS
C1 [Chen, L.; Peek, M.; Stokich, D.; Todd, R.; Anderson, M.] Washoe Cty Hlth Dist, Reno, NV USA.
[Murphy, F. K.] Sierra Infect Dis, Reno, NV USA.
[Jordan-Villegas, A.; McCracken, G., Jr.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
[Hills, S. L.; Lambert, A.; Panella, A.; Laven, J.; Kosoy, O.; Johnson, B. W.; Lanciotti, R. S.; Fischer, M.] CDC, Arboviral Dis Br, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
RP Chen, L (reprint author), Washoe Cty Hlth Dist, Reno, NV USA.
NR 11
TC 0
Z9 0
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 22
PY 2011
VL 305
IS 24
BP 2516
EP 2518
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 780MF
UT WOS:000291860400011
ER
PT J
AU Georgea, DB
Webb, CT
Farnsworth, ML
O'Shea, TJ
Bowen, RA
Smith, DL
Stanley, TR
Ellison, LE
Rupprecht, CE
AF Georgea, Dylan B.
Webb, Colleen T.
Farnsworth, Matthew L.
O'Shea, Thomas J.
Bowen, Richard A.
Smith, David L.
Stanley, Thomas R.
Ellison, Laura E.
Rupprecht, Charles E.
TI Host and viral ecology determine bat rabies seasonality and maintenance
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE chiroptera; pathogen persistence; torpor
ID BIG BROWN BATS; EPTESICUS-FUSCUS; UNITED-STATES; DYNAMICS; COLORADO;
PROBABILITIES; DISEASE; EPIDEMIOLOGY; SURVEILLANCE; TRANSMISSION
AB Rabies is an acute viral infection that is typically fatal. Most rabies modeling has focused on disease dynamics and control within terrestrial mammals (e. g., raccoons and foxes). As such, rabies in bats has been largely neglected until recently. Because bats have been implicated as natural reservoirs for several emerging zoonotic viruses, including SARS-like corona viruses, henipaviruses, and lyssaviruses, understanding how pathogens are maintained within a population becomes vital. Unfortunately, little is known about maintenance mechanisms for any pathogen in bat populations. We present a mathematical model parameterized with unique data from an extensive study of rabies in a Colorado population of big brown bats (Eptesicus fuscus) to elucidate general maintenance mechanisms. We propose that life history patterns of many species of temperate-zone bats, coupled with sufficiently long incubation periods, allows for rabies virus maintenance. Seasonal variability in bat mortality rates, specifically low mortality during hibernation, allows long-term bat population viability. Within viable bat populations, sufficiently long incubation periods allow enough infected individuals to enter hibernation and survive until the following year, and hence avoid an epizootic fadeout of rabies virus. We hypothesize that the slowing effects of hibernation on metabolic and viral activity maintains infected individuals and their pathogens until susceptibles from the annual birth pulse become infected and continue the cycle. This research provides a context to explore similar host ecology and viral dynamics that may explain seasonal patterns and maintenance of other bat-borne diseases.
C1 [Georgea, Dylan B.; Webb, Colleen T.] Colorado State Univ, Dept Biol, Ft Collins, CO 80523 USA.
[Georgea, Dylan B.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
[Farnsworth, Matthew L.; Bowen, Richard A.] Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA.
[Smith, David L.] Univ Florida, Dept Biol, Gainesville, FL 32610 USA.
[Smith, David L.] Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32610 USA.
[O'Shea, Thomas J.; Stanley, Thomas R.; Ellison, Laura E.] US Geol Survey, Ft Collins Sci Ctr, Ft Collins, CO 80526 USA.
[Rupprecht, Charles E.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Georgea, DB (reprint author), Colorado State Univ, Dept Biol, Ft Collins, CO 80523 USA.
EM dylangeorge@gmail.com
RI Smith, David/L-8850-2013
OI Smith, David/0000-0003-4367-3849
FU National Science Foundation [EF-0094959, DGE-0221595]; Science and
Technology Directorate in the Department of Homeland Security; Fogarty
International Center, National Institutes of Health; US Geological
Survey; Department of Defense
FX We are grateful for data from the Colorado Department of Public Health
and Environment. We thank state public health departments and diagnostic
laboratories for collecting primary data and staff at the Center for
Disease Control Rabies Program for data compilation. We acknowledge
support from National Science Foundation Ecology of Infectious Disease
Grant EF-0094959; the Research And Policy In Disease Dynamics program of
the Science and Technology Directorate in the Department of Homeland
Security; the Fogarty International Center, National Institutes of
Health; and the US Geological Survey. Additional support was provided by
National Science Foundation Integrative Graduate Education and Research
Training Fellowship DGE-0221595 and a Department of Defense Science,
Mathematics, and Research for Transformation (SMART) Fellowship (to
D.B.G.).
NR 37
TC 55
Z9 55
U1 2
U2 58
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUN 21
PY 2011
VL 108
IS 25
BP 10208
EP 10213
DI 10.1073/pnas.1010875108
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 780LK
UT WOS:000291857500040
PM 21646516
ER
PT J
AU Shebl, FM
Dollard, SC
Pfeiffer, RM
Biryahwaho, B
Amin, MM
Munuo, SS
Hladik, W
Parsons, R
Graubard, BI
Mbulaiteye, SM
AF Shebl, Fatma M.
Dollard, Sheila C.
Pfeiffer, Ruth M.
Biryahwaho, Benon
Amin, Minal M.
Munuo, Stella S.
Hladik, Wolfgang
Parsons, Ruth
Graubard, Barry I.
Mbulaiteye, Sam M.
TI Human Herpesvirus 8 Seropositivity Among Sexually Active Adults in
Uganda
SO PLOS ONE
LA English
DT Article
ID SARCOMA-ASSOCIATED HERPESVIRUS; TO-CHILD TRANSMISSION; KAPOSIS-SARCOMA;
RISK-FACTORS; INFECTION; SEROPREVALENCE; POPULATION; CANCER; AIDS;
TRANSFUSION
AB Introduction: Sexual transmission of human herpesvirus 8 (HHV8) has been implicated among homosexual men, but the evidence for sexual transmission among heterosexual individuals is controversial. We investigated the role of sexual transmission of HHV8 in a nationally representative sample in Uganda, where HHV8 infection is endemic and transmitted mostly during childhood.
Materials and Methods: The study population was a subset of participants (n = 2681) from a population-based HIV/AIDS serobehavioral survey of adults aged 15-59 years conducted in 2004/2005. High risk for sexual transmission was assessed by questionnaire and serological testing for HIV and herpes simplex virus 2. Anti-HHV8 antibodies were measured using two enzyme immunoassays targeting synthetic peptides from the K8.1 and orf65 viral genes. The current study was restricted to 2288 sexually active adults. ORs and 95% CIs for HHV8 seropositivity were estimated by fitting logistic regression models with a random intercept using MPLUS and SAS software.
Results: The weighted prevalence of HHV8 seropositivity was 56.2%, based on 1302 seropositive individuals, and it increased significantly with age (P(trend)<0.0001). In analyses adjusting for age, sex, geography, education, and HIV status, HHV8 seropositivity was positively associated with reporting two versus one marital union (OR:1.52, 95% CI: 1.17-1.97) and each unit increase in the number of children born (OR: 1.04, 95% CI: 1.00-1.08), and was inversely associated with ever having used a condom (OR: 0.64, 95% CI: 0.45-0.89). HHV8 seropositivity was not associated with HIV (P = 0.660) or with herpes simplex virus 2 (P = 0.732) seropositivity. Other sexual variables, including lifetime number of sexual partners or having had at least one sexually transmitted disease, and socioeconomic variables were unrelated to HHV8 seropositivity.
Conclusion: Our findings are compatible with the conclusion that sexual transmission of HHV8 in Uganda, if it occurs, is weak.
C1 [Shebl, Fatma M.; Pfeiffer, Ruth M.; Graubard, Barry I.; Mbulaiteye, Sam M.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Dollard, Sheila C.; Amin, Minal M.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Biryahwaho, Benon] Uganda Virus Res Inst, Entebbe, Uganda.
[Munuo, Stella S.; Parsons, Ruth] Informat Management Serv Inc, Rockville, MD USA.
[Hladik, Wolfgang] Ctr Dis Control & Prevent, Entebbe, Uganda.
RP Shebl, FM (reprint author), NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
EM mbulaits@mail.nih.gov
RI Pfeiffer, Ruth /F-4748-2011
FU Division of Cancer Epidemiology and Genetics, National Cancer Institute
(NCI); National Institutes of Health, Department of Health and Human
Services [HHSN2612009004060P]; Support Services contract [NO2-CP-31003];
NCI [IAA Y1CP903801]; Centers for Disease Control and Prevention [IAA
Y1CP903801]
FX The study was supported by the Intramural Research Program of the
Division of Cancer Epidemiology and Genetics, National Cancer Institute
(NCI), National Institutes of Health, Department of Health and Human
Services (contract HHSN2612009004060P and Support Services contract
NO2-CP-31003) and with an Inter-Agency Agreement between NCI and the
Centers for Disease Control and Prevention (IAA Y1CP903801). The funders
had no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 38
TC 12
Z9 12
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 21
PY 2011
VL 6
IS 6
AR e21286
DI 10.1371/journal.pone.0021286
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 782CL
UT WOS:000291985100025
PM 21712983
ER
PT J
AU Zeh, C
Amornkul, PN
Inzaule, S
Ondoa, P
Oyaro, B
Mwaengo, DM
Vandenhoudt, H
Gichangi, A
Williamson, J
Thomas, T
DeCock, KM
Hart, C
Nkengasong, J
Laserson, K
AF Zeh, Clement
Amornkul, Pauli N.
Inzaule, Seth
Ondoa, Pascale
Oyaro, Boaz
Mwaengo, Dufton M.
Vandenhoudt, Hilde
Gichangi, Anthony
Williamson, John
Thomas, Timothy
DeCock, Kevin M.
Hart, Clyde
Nkengasong, John
Laserson, Kayla
TI Population-Based Biochemistry, Immunologic and Hematological Reference
Values for Adolescents and Young Adults in a Rural Population in Western
Kenya
SO PLOS ONE
LA English
DT Article
ID IMMUNOHEMATOLOGICAL REFERENCE RANGES; ANTIRETROVIRAL THERAPY; REFERENCE
INTERVALS; LYMPHOCYTE COUNTS; PLATELET COUNT; HEALTHY-ADULTS;
RISK-FACTORS; CELL COUNT; TANZANIA; HIV-1
AB Background: There is need for locally-derived age-specific clinical laboratory reference ranges of healthy Africans in sub-Saharan Africa. Reference values from North American and European populations are being used for African subjects despite previous studies showing significant differences. Our aim was to establish clinical laboratory reference values for African adolescents and young adults that can be used in clinical trials and for patient management.
Methods and Findings: A panel of 298, HIV-seronegative individuals aged 13-34 years was randomly selected from participants in two population-based cross-sectional surveys assessing HIV prevalence and other sexually transmitted infections in western Kenya. The adolescent (<18 years)-to-adults (>= 18 years) ratio and the male-to-female ratio was 1:1. Median and 95% reference ranges were calculated for immunohematological and biochemistry values. Compared with U. S-derived reference ranges, we detected lower hemoglobin (HB), hematocrit (HCT), red blood cells (RBC), mean corpuscular volume (MCV), neutrophil, glucose, and blood urea nitrogen values but elevated eosinophil and total bilirubin values. Significant gender variation was observed in hematological parameters in addition to T-bilirubin and creatinine indices in all age groups, AST in the younger and neutrophil, platelet and CD4 indices among the older age group. Age variation was also observed, mainly in hematological parameters among males. Applying U. S. NIH Division of AIDS (DAIDS) toxicity grading to our results, 40% of otherwise healthy study participants were classified as having an abnormal laboratory parameter (grade 1-4) which would exclude them from participating in clinical trials.
Conclusion: Hematological and biochemistry reference values from African population differ from those derived from a North American population, showing the need to develop region-specific reference values. Our data also show variations in hematological indices between adolescent and adult males which should be considered when developing reference ranges. This study provides the first locally-derived clinical laboratory reference ranges for adolescents and young adults in western Kenya.
C1 [Zeh, Clement; Amornkul, Pauli N.; Mwaengo, Dufton M.; Gichangi, Anthony; Williamson, John; Thomas, Timothy; DeCock, Kevin M.; Laserson, Kayla] US Ctr Dis Control & Prevent CDC Kenya, Kisumu, Kenya.
[Inzaule, Seth; Oyaro, Boaz] Kenya Med Res Inst US CDC Res & Publ Hlth, Ctr Global Hlth Res, Kisumu, Kenya.
[Ondoa, Pascale] Univ Amsterdam, Acad Med Ctr,Ctr Poverty Related Communicable Dis, Amsterdam Inst Global Hlth & Dev AIGHD, Dept Internal Med,Ctr Infect & Immun CINIMA, NL-1105 AZ Amsterdam, Netherlands.
[Vandenhoudt, Hilde] Inst Trop Med ITM, Antwerp, Belgium.
[Hart, Clyde; Nkengasong, John] US Ctr Dis Control & Prevent, Global AIDS Program, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA.
RP Zeh, C (reprint author), US Ctr Dis Control & Prevent CDC Kenya, Kisumu, Kenya.
EM czeh@ke.cdc.gov
FU Kenya Medical Research Institute; U.S. Centers for Disease Control and
Prevention (CDC), Division of HIV/AIDS Prevention-Surveillance and
Epidemiology [5U19C1000323-04]
FX This work was supported by the Kenya Medical Research Institute through
a cooperative agreement with the U.S. Centers for Disease Control and
Prevention (CDC), Division of HIV/AIDS Prevention-Surveillance and
Epidemiology, grant award number-5U19C1000323-04. The study design, data
collection instruments, data analysis, decision to publish, and
preparation of manuscript was led by scientists at the CDC and stationed
in Kenya. Data collection was done by Kenyan staff working for a
CDC-funded research station in Kisumu, Kenya. The findings and
conclusions in this article are those of the authors and do not
necessarily represent the views of the U. S. Centers for Disease Control
and Prevention. Use of trade names is for identification purposes only
and does not constitute endorsement by the U. S. Centers for Disease
Control and Prevention or the Department of Health and Human Services.
NR 48
TC 22
Z9 23
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 21
PY 2011
VL 6
IS 6
AR e21040
DI 10.1371/journal.pone.0021040
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 782CL
UT WOS:000291985100008
PM 21713038
ER
PT J
AU Gallardo-Romero, NF
Velasco-Villa, A
Weiss, SL
Emerson, GL
Carroll, DS
Hughes, CM
Li, Y
Karem, KL
Damon, IK
Olson, VA
AF Gallardo-Romero, Nadia F.
Velasco-Villa, Andres
Weiss, Sonja L.
Emerson, Ginny L.
Carroll, Darin S.
Hughes, Christine M.
Li, Yu
Karem, Kevin L.
Damon, Inger K.
Olson, Victoria A.
TI Detection of North American orthopoxviruses by real time-PCR
SO VIROLOGY JOURNAL
LA English
DT Article
DE orthopoxviruses; North American orthopoxviruses; myristylated protein;
real time PCR
ID RACCOON POXVIRUS; MONKEYPOX-VIRUS; WEST-AFRICAN; PRAIRIE DOG;
IMMUNIZATION; CONSUMPTION; VACCINE; PROTEIN; PLAGUE; RABIES
AB The prevalence of North American orthopoxviruses in nature is unknown and may be more difficult to ascertain due to wide spread use of vaccinia virus recombinant vaccines in the wild. A real time PCR assay was developed to allow for highly sensitive and specific detection of North American orthopoxvirus DNA in animal tissues and bodily fluids. This method is based on the amplification of a 156 bp sequence within a myristylated protein, highly conserved within the North American orthopoxviruses but distinct from orthologous genes present in other orthopoxviruses. The analytical sensitivity was 1.1 fg for Volepox virus DNA, 1.99 fg for Skunkpox virus DNA, and 6.4 fg for Raccoonpox virus DNA with a 95% confidence interval. Our assay did not cross-react with other orthopoxviruses or ten diverse representatives of the Chordopoxvirinae subfamily. This new assay showed more sensitivity than tissue culture tests, and was capable of differentiating North American orthopoxviruses from other members of Orthopoxvirus. Thus, our assay is a promising tool for highly sensitive and specific detection of North American orthopoxviruses in the United States and abroad.
C1 [Gallardo-Romero, Nadia F.; Velasco-Villa, Andres; Weiss, Sonja L.; Emerson, Ginny L.; Carroll, Darin S.; Hughes, Christine M.; Li, Yu; Karem, Kevin L.; Damon, Inger K.; Olson, Victoria A.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Poxvirus & Rabies Branch, Atlanta, GA 30333 USA.
RP Gallardo-Romero, NF (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Poxvirus & Rabies Branch, Atlanta, GA 30333 USA.
EM hfa5@cdc.gov
NR 26
TC 3
Z9 3
U1 0
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD JUN 20
PY 2011
VL 8
AR 313
DI 10.1186/1743-422X-8-313
PG 7
WC Virology
SC Virology
GA 797QM
UT WOS:000293142400001
PM 21689420
ER
PT J
AU Apondi, R
Bunnell, R
Ekwaru, JP
Moore, D
Bechange, S
Khana, K
King, R
Campbell, J
Tappero, J
Mermin, J
AF Apondi, Rose
Bunnell, Rebecca
Ekwaru, John Paul
Moore, David
Bechange, Stevens
Khana, Kenneth
King, Rachel
Campbell, James
Tappero, Jordan
Mermin, Jonathan
TI Sexual behavior and HIV transmission risk of Ugandan adults taking
antiretroviral therapy: 3 year follow-up
SO AIDS
LA English
DT Article
DE Africa; antiretroviral therapy; epidemiology; prevention of sexual
transmission; sexual behavior; Uganda; viral load
ID RURAL UGANDA; DEVELOPING-COUNTRIES; INFECTED ADULTS; SOUTH-AFRICA; VIRAL
LOAD; CAPE-TOWN; EPIDEMIC; MEN; PREVENTION; MORTALITY
AB Background: Long-term impact of antiretroviral therapy (ART) on sexual HIV-transmission risk in Africa is unknown. We assessed sexual behavior changes and estimated HIV transmission from HIV-infected adults on ART in Uganda.
Methods: Between 2003 and 2007, we enrolled and followed ART-naive HIV-infected adults in a home-based AIDS program with annual counseling and testing for cohabitating partners, participant transmission risk-reduction plans, condom distribution and prevention support for cohabitating discordant couples. We assessed participants' HIV plasma viral load and partner-specific sexual behaviors. We defined risky sex as intercourse with inconsistent/no condom use with HIV-negative or unknown serostatus partners in previous 3 months. We compared rates using Poisson regression models, estimated transmission risk using established viral load-specific transmission estimates, and documented sero-conversion rates among HIV-discordant couples.
Results: Of 928 participants, 755 (81%) had 36 months data: 94 (10%) died and 79 (9%) missing data. Sexual activity increased from 28% (baseline) to 41% [36 months (P<0.001)]. Of sexually active participants, 22% reported risky sex at baseline, 8% at 6 months (P<0.001), and 14% at 36 months (P = 0.018). Median viral load among those reporting risky sex was 122 500 [interquartile range (IQR) 45 100-353 000] copies/ml pre-ART at baseline and undetectable at follow-up. One sero-conversion occurred among 62 cohabitating sero-discordant partners (0.5 sero-conversions/100 person-years). At 36 months, consistent condom use was 74% with discordant partners, 55% with unknown and 46% with concordant partners. Estimated HIV transmission risk reduced 91%, from 47.3 to 4.2/1000 person-years.
Conclusions: Despite increased sexual activity among HIV-infected Ugandans over 3 years on ART, risky sex and estimated risk of HIV transmission remained lower than baseline levels. Integrated prevention programs could reduce HIV transmission in Africa. (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
C1 [Apondi, Rose; Ekwaru, John Paul; Bechange, Stevens; Khana, Kenneth; Campbell, James] Ctr Dis Control & Prevent, Natl Ctr HIV STD & TB Prevent, CDC Uganda, Entebbe, Uganda.
[Bunnell, Rebecca; Tappero, Jordan; Mermin, Jonathan] Ctr Dis Control & Prevent, CDC Uganda, Natl Ctr HIV STD & TB Prevent, Atlanta, GA USA.
[Moore, David] Univ British Columbia, British Columbia Ctr Excellence HIV AIDS, Vancouver, BC V5Z 1M9, Canada.
[Moore, David] Univ British Columbia, Fac Med, Dept Med, Vancouver, BC, Canada.
[King, Rachel] Univ Calif San Francisco, San Francisco, CA 94143 USA.
RP Apondi, R (reprint author), Uganda Virus Res Inst, POB 49, Entebbe, Uganda.
EM hmm9@ug.cdc.gov
RI Mermin, Jonathan/J-9847-2012
FU Ministry of Health
FX We thank HBAC project staff and clients for all their time and efforts.
Dr R. Downing supervised all laboratory work. We also thank Dr E. Madraa
and The Ministry of Health for support for this project. We are grateful
to T. Wamala and G. Nagadya for help with the references.
NR 30
TC 27
Z9 28
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0269-9370
J9 AIDS
JI Aids
PD JUN 19
PY 2011
VL 25
IS 10
BP 1317
EP 1327
DI 10.1097/QAD.0b013e328347f775
PG 11
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 775MI
UT WOS:000291463200009
PM 21522005
ER
PT J
AU Saraiya, M
Hariri, S
AF Saraiya, Mona
Hariri, Susan
TI HPV vaccine effect: is the glass half full or half empty?
SO LANCET
LA English
DT Editorial Material
ID SURVEILLANCE; AUSTRALIA; IMPACT
C1 [Saraiya, Mona; Hariri, Susan] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
RP Saraiya, M (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
EM msaraiya@cdc.gov
NR 11
TC 3
Z9 3
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
J9 LANCET
JI Lancet
PD JUN 18
PY 2011
VL 377
IS 9783
BP 2057
EP 2058
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 783XI
UT WOS:000292117800004
PM 21684367
ER
PT J
AU Coleman, CN
Simon, SL
Noska, MA
Telfer, JL
Bowman, T
AF Coleman, C. Norman
Simon, Steven L.
Noska, Michael A.
Telfer, Jana L.
Bowman, Thomas
TI Disaster Preparation: Lessons from Japan
SO SCIENCE
LA English
DT Letter
C1 [Coleman, C. Norman] NCI, Washington, DC 20201 USA.
[Coleman, C. Norman] US Dept HHS, Off Preparedness & Emergency Operat, Washington, DC 20201 USA.
[Simon, Steven L.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
[Noska, Michael A.] US PHS, US FDA, Silver Spring, MD 20993 USA.
[Telfer, Jana L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Agcy Tox Subst & Dis Registry, Atlanta, GA 30341 USA.
[Bowman, Thomas] Ctr Dis Control & Prevent, US Publ Hlth Serv, Div Strateg Natl Stockpile, Off Publ Hlth Preparedness & Response, Atlanta, GA 30329 USA.
RP Coleman, CN (reprint author), NCI, 200 Independence Ave SW, Washington, DC 20201 USA.
EM ccoleman@mail.nih.gov
NR 0
TC 5
Z9 6
U1 0
U2 14
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD JUN 17
PY 2011
VL 332
IS 6036
BP 1379
EP 1379
PG 1
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 778FT
UT WOS:000291689000018
PM 21680826
ER
PT J
AU Mosoko, JJ
Akam, W
Weidle, PJ
Brooks, JT
Aweh, AJ
Kinge, TN
Pals, S
Raghunathan, PL
AF Mosoko, Jembia J.
Akam, Wilfred
Weidle, Paul J.
Brooks, John T.
Aweh, Asabi J.
Kinge, Thompson N.
Pals, Sherri
Raghunathan, Pratima L.
TI Retention in an antiretroviral therapy programme during an era of
decreasing drug cost in Limbe, Cameroon
SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
LA English
DT Article
ID HIV-1-INFECTED ADULTS; SOUTH-AFRICA; ADHERENCE; CARE; OUTCOMES;
KHAYELITSHA; MORTALITY; RESPONSES; FAILURE; PROJECT
AB Background: In 2002, Cameroon initiated scale up of antiretroviral therapy (ART); on 1 October 2004, a substantial reduction in ART cost occurred. We assessed the impact of this event and other factors on enrolment and retention in care among HIV-infected patients initiating ART from February 2002 to December 2005 at the single ART clinic serving the Southwest Region in Limbe, Cameroon.
Methods: We retrospectively analyzed clinical and pharmacy payment records of HIV-infected patients initiating ART according to national guidelines. We compared two cohorts of patients, enrolled before and after 1 October 2004, to determine if price reduction was associated with enhanced enrolment. We assessed factors associated with retention and survival by Cox proportional hazards models. Retention in care implied patients who had contact with the healthcare system as of 31 December 2005 (including those who were transferred to continue care in other ART centres), although these patients may have interrupted therapy at some time. A patient who was not retained in care may have dropped out (lost to follow up) or died.
Results: Mean enrolment rates for 2920 patients who initiated ART before and after the price reduction were 46.5 and 95.5 persons/month, respectively (p < 0.001). The probabilities of remaining alive and in care were 0.66 (95% CI 0.64-0.68) at six months, 0.58 (95% CI 0.56-0.60) at one year, 0.47 (95% CI 0.45-0.49) at two years and 0.35 (95% CI 0.32-0.38) at three years; they were not significantly different between the two cohorts of patients enrolled before and after the price reduction over the first 15 months of comparable follow up (hazard ratio 1.1; 95% CI 0.9-1.2, p = 0.27). In multivariable analysis using multiple imputations to compensate for missing values, factors associated with dropping out of care or dying were male gender (HR 1.33 [1.18-1.50], p = 0.003), treatment paid by self, family or partly by other (HR 3.05 [1.99-4.67], p < 0.001), and, compared with residents of Limbe, living more than 150 km from Limbe (HR 1.41 [1.18-1.69], p < 0.001), or being residents of Douala (HR 1.51 [1.16-1.98], p < 0.001).
Conclusions: Reducing the cost of ART increased enrolment of clients in the programme, but did not change retention in care. In a system where most clients pay for ART, an accessible clinic location may be more important than the cost of medication for retention in care. Decentralizing ART clinics might improve retention and survival among patients on ART.
C1 [Mosoko, Jembia J.; Raghunathan, Pratima L.] Ctr Dis Control & Prevent, Div Global HIV AIDS, Mutengene, Cameroon.
[Mosoko, Jembia J.; Weidle, Paul J.; Brooks, John T.; Aweh, Asabi J.; Pals, Sherri; Raghunathan, Pratima L.] Ctr Dis Control & Prevent, Div HIV AIDS, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA.
RP Mosoko, JJ (reprint author), Ctr Dis Control & Prevent, Div Global HIV AIDS, Mutengene, Cameroon.
EM jmosoko@cdc.gov
FU President's Emergency Plan for AIDS Relief (PEPFAR); Department of
Health and Human Services/CDC; Division of Global HIV/AIDS; CDC Division
of HIV/AIDS Prevention
FX This publication was made possible by support from the President's
Emergency Plan for AIDS Relief (PEPFAR), from the Department of Health
and Human Services/CDC, Division of Global HIV/AIDS and the CDC Division
of HIV/AIDS Prevention.
NR 25
TC 7
Z9 7
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-2652
J9 J INT AIDS SOC
JI J. Int. AIDS Soc.
PD JUN 16
PY 2011
VL 14
AR 32
DI 10.1186/1758-2652-14-32
PG 10
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 839GH
UT WOS:000296353000001
PM 21679416
ER
PT J
AU Florence, C
Shepherd, J
Brennan, I
Simon, T
AF Florence, Curtis
Shepherd, Jonathan
Brennan, Iain
Simon, Thomas
TI Effectiveness of anonymised information sharing and use in health
service, police, and local government partnership for preventing
violence related injury: experimental study and time series analysis
SO BRITISH MEDICAL JOURNAL
LA English
DT Article
ID URBAN VIOLENCE; ASSAULT; ACCIDENT; CRIME
AB Objective To evaluate the effectiveness of anonymised information sharing to prevent injury related to violence.
Design Experimental study and time series analysis of a prototype community partnership between the health service, police, and local government partners designed to prevent violence.
Setting Cardiff, Wales, and 14 comparison cities designated "most similar" by the Home Office in England and Wales.
Intervention After a 33 month development period, anonymised data relevant to violence prevention (precise violence location, time, days, and weapons) from patients attending emergency departments in Cardiff and reporting injury from violence were shared over 51 months with police and local authority partners and used to target resources for violence prevention.
Main outcome measures Health service records of hospital admissions related to violence and police records of woundings and less serious assaults in Cardiff and other cities after adjustment for potential confounders.
Results Information sharing and use were associated with a substantial and significant reduction in hospital admissions related to violence. In the intervention city (Cardiff) rates fell from seven to five a month per 100 000 population compared with an increase from five to eight in comparison cities (adjusted incidence rate ratio 0.58, 95% confidence interval 0.49 to 0.69). Average rate of woundings recorded by the police changed from 54 to 82 a month per 100 000 population in Cardiff compared with an increase from 54 to 114 in comparison cities (adjusted incidence rate ratio 0.68, 0.61 to 0.75). There was a significant increase in less serious assaults recorded by the police, from 15 to 20 a month per 100 000 population in Cardiff compared with a decrease from 42 to 33 in comparison cities (adjusted incidence rate ratio 1.38, 1.13 to 1.70).
Conclusion An information sharing partnership between health services, police, and local government in Cardiff, Wales, altered policing and other strategies to prevent violence based on information collected from patients treated in emergency departments after injury sustained in violence. This intervention led to a significant reduction in violent injury and was associated with an increase in police recording of minor assaults in Cardiff compared with similar cities in England and Wales where this intervention was not implemented.
C1 [Shepherd, Jonathan] Cardiff Univ, Violence & Soc Res Grp, Sch Dent, Cardiff CF14 4XY, S Glam, Wales.
[Florence, Curtis; Simon, Thomas] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA USA.
[Brennan, Iain] Univ Hull, Dept Social Sci, Kingston Upon Hull HU6 7RX, N Humberside, England.
RP Shepherd, J (reprint author), Cardiff Univ, Violence & Soc Res Grp, Sch Dent, Cardiff CF14 4XY, S Glam, Wales.
EM shepherdjp@cardiff.ac.uk
FU Home Office; Wales Office for Research and Development in Health and
Social Care (WORD) [R/98/037]
FX The development of the prototype partnership was funded in part by a
grant from the Home Office targeted policing fund. The study was funded
in part by the Wales Office for Research and Development in Health and
Social Care (WORD), grant No R/98/037.
NR 45
TC 33
Z9 33
U1 3
U2 20
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-535X
J9 BRIT MED J
JI Br. Med. J.
PD JUN 16
PY 2011
VL 342
AR d3313
DI 10.1136/bmj.d3313
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA 781LF
UT WOS:000291933000004
PM 21680632
ER
PT J
AU Patel, MM
Lopez-Collada, VR
Bulhoes, MM
De Oliveira, LH
Marquez, AB
Flannery, B
Esparza-Aguilar, M
Renoiner, EIM
Luna-Cruz, ME
Sato, HK
Hernandez-Hernandez, LD
Toledo-Cortina, G
Ceron-Rodriguez, M
Osnaya-Romero, N
Martinez-Alcazar, M
Aguinaga-Villasenor, RG
Plascencia-Hernandez, A
Fojaco-Gonzalez, F
Rezk, GHP
Gutierrez-Ramirez, SF
Dorame-Castillo, R
Tinajero-Pizano, R
Mercado-Villegas, B
Barbosa, MR
Maluf, EMC
Ferreira, LB
de Carvalho, FM
dos Santos, AR
Cesar, ED
de Oliveira, MEP
Silva, CLO
Cortes, MD
Matus, CR
Tate, J
Gargiullo, P
Parashar, UD
AF Patel, Manish M.
Richardson Lopez-Collada, Vesta
Bulhoes, Marilia Mattos
Helena De Oliveira, Lucia
Bautista Marquez, Aurora
Flannery, Brendan
Esparza-Aguilar, Marcelino
Montenegro Renoiner, Ernesto Isaac
Edilia Luna-Cruz, Maria
Sato, Helena Keico
del Carmen Hernandez-Hernandez, Luz
Toledo-Cortina, Gerardo
Ceron-Rodriguez, Magdalena
Osnaya-Romero, Neydi
Martinez-Alcazar, Mario
Gabriela Aguinaga-Villasenor, Rocio
Plascencia-Hernandez, Arturo
Fojaco-Gonzalez, Francisco
Hernandez-Peredo Rezk, Guillermo
Fortino Gutierrez-Ramirez, Sixto
Dorame-Castillo, Roberto
Tinajero-Pizano, Rogelio
Mercado-Villegas, Bernice
Barbosa, Marilia Reichelt
Cesario Maluf, Eliane Mara
Ferreira, Lucimar Bozza
de Carvalho, Francisca Maria
dos Santos, Ana Rosa
Cesar, Eduardo Dolabella
Paula de Oliveira, Maria Elisa
Osterno Silva, Carmem Lucia
de los Angeles Cortes, Maria
Ruiz Matus, Cuauhtemoc
Tate, Jacqueline
Gargiullo, Paul
Parashar, Umesh D.
TI Intussusception Risk and Health Benefits of Rotavirus Vaccination in
Mexico and Brazil
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID CASE SERIES; CHILDHOOD DIARRHEA; INFANTS; SAFETY; EFFICACY;
GASTROENTERITIS; CHILDREN; IMMUNIZATION; VACCINES
AB Background
Because postlicensure surveillance determined that a previous rotavirus vaccine, RotaShield, caused intussusception in 1 of every 10,000 recipients, we assessed the association of the new monovalent rotavirus vaccine (RV1) with intussusception after routine immunization of infants in Mexico and Brazil.
Methods
We used case-series and case-control methods to assess the association between RV1 and intussusception. Infants with intussusception were identified through active surveillance at 69 hospitals (16 in Mexico and 53 in Brazil), and age-matched infants from the same neighborhood were enrolled as controls. Vaccination dates were verified by a review of vaccination cards or clinic records.
Results
We enrolled 615 case patients (285 in Mexico and 330 in Brazil) and 2050 controls. An increased risk of intussusception 1 to 7 days after the first dose of RV1 was identified among infants in Mexico with the use of both the case-series method (incidence ratio, 5.3; 95% confidence interval [CI], 3.0 to 9.3) and the case-control method (odds ratio, 5.8; 95% CI, 2.6 to 13.0). No significant risk was found after the first dose among infants in Brazil, but an increased risk, albeit smaller than that seen after the first dose in Mexico - an increase by a factor of 1.9 to 2.6 - was seen 1 to 7 days after the second dose. A combined annual excess of 96 cases of intussusception in Mexico (approximately 1 per 51,000 infants) and in Brazil (approximately 1 per 68,000 infants) and of 5 deaths due to intussusception was attributable to RV1. However, RV1 prevented approximately 80,000 hospitalizations and 1300 deaths from diarrhea each year in these two countries.
Conclusions
RV1 was associated with a short-term risk of intussusception in approximately 1 of every 51,000 to 68,000 vaccinated infants. The absolute number of deaths and hospitalizations averted because of vaccination far exceeded the number of intussusception cases that may have been associated with vaccination. (Funded in part by the GAVI Alliance and the U. S. Department of Health and Human Services.)
C1 [Patel, Manish M.; Tate, Jacqueline; Gargiullo, Paul; Parashar, Umesh D.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Richardson Lopez-Collada, Vesta; Bautista Marquez, Aurora; Esparza-Aguilar, Marcelino; Edilia Luna-Cruz, Maria; del Carmen Hernandez-Hernandez, Luz] Minist Hlth, Natl Ctr Child & Adolescent Hlth, Mexico City, DF, Mexico.
[Toledo-Cortina, Gerardo] Hosp Pediat Moctezuma, Mexico City, DF, Mexico.
[Ceron-Rodriguez, Magdalena] Hosp Infantil Mexico Dr Federico Gomez, Mexico City, DF, Mexico.
[Osnaya-Romero, Neydi] Inst Nacl Pediat, Mexico City, DF, Mexico.
[Bulhoes, Marilia Mattos; Montenegro Renoiner, Ernesto Isaac; dos Santos, Ana Rosa] Minist Hlth, Secretariat Hlth Surveillance, Brasilia, DF, Brazil.
[Montenegro Renoiner, Ernesto Isaac] Univ Brasilia, Nucleo Med Trop, Brasilia, DF, Brazil.
[Flannery, Brendan] Pan Amer Hlth Org, Brasilia, DF, Brazil.
[Sato, Helena Keico] Secretaria Estado Saude Sao Paulo, Sao Paulo, Brazil.
[Ferreira, Lucimar Bozza] Secretaria Municipal Saude Curitiba, Curitiba, Parana, Brazil.
[de Carvalho, Francisca Maria] Secretaria Estado Saude Rio de Janeiro, Rio De Janeiro, Brazil.
[Cesar, Eduardo Dolabella] Secretaria Estado Saude Minas Gerais, Belo Horizonte, MG, Brazil.
[Osterno Silva, Carmem Lucia] Secretaria Estado Saude Curitiba, Ceara, Brazil.
[Helena De Oliveira, Lucia; de los Angeles Cortes, Maria; Ruiz Matus, Cuauhtemoc] Pan Amer Hlth Org, Washington, DC USA.
[Osnaya-Romero, Neydi] Hosp Nino Morelense, Cuernavaca, Morelos, Mexico.
[Martinez-Alcazar, Mario; Gabriela Aguinaga-Villasenor, Rocio] Hosp Infantil Morelia Eva Samano de Lopez Mateos, Morelia, Michoacan, Mexico.
[Plascencia-Hernandez, Arturo] Hosp Civil Reg Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico.
[Plascencia-Hernandez, Arturo] Hosp Civil Nuevo Guadalajara Juan I Menchaca, Guadalajara, Jalisco, Mexico.
[Fojaco-Gonzalez, Francisco] Hosp Alta Especialidad Nino Dr Rodolfo Nieto Padr, Villahermosa, Tabasco, Mexico.
[Hernandez-Peredo Rezk, Guillermo] Ctr Especialidades Med Veracruz, Xalapa, Veracruz, Mexico.
[Fortino Gutierrez-Ramirez, Sixto] Hosp Metropolitano Dr Bernardo Sepulveda, Monterrey, Nuevo Leon, Mexico.
[Dorame-Castillo, Roberto] Hosp Infantil Estado Sonora, Hermosillo, Sonora, Mexico.
[Tinajero-Pizano, Rogelio] Hosp Gen Reg Leon, Guanajuato, Mexico.
[Mercado-Villegas, Bernice] Hosp Civil Tepic Dr Antonio Gonzalez Guevara, Tepic, Nayarit, Mexico.
RP Patel, MM (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS A-47, Atlanta, GA 30333 USA.
EM mpatel@cdc.gov
FU GAVI Alliance; U.S. Department of Health and Human Services
FX Funded in part by the GAVI Alliance under a collaborative agreement with
the Program for Appropriate Technology in Health (PATH) and in part by
the U.S. Department of Health and Human Services.
NR 31
TC 171
Z9 180
U1 2
U2 13
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
EI 1533-4406
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD JUN 16
PY 2011
VL 364
IS 24
BP 2283
EP 2292
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA 777RZ
UT WOS:000291643800006
PM 21675888
ER
PT J
AU Sow, SO
Okoko, BJ
Diallo, A
Viviani, S
Borrow, R
Carlone, G
Tapia, M
Akinsola, AK
Arduin, P
Findlow, H
Elie, C
Haidara, FC
Adegbola, RA
Diop, D
Parulekar, V
Chaumont, J
Martellet, L
Diallo, F
Idoko, OT
Tang, YX
Plikaytis, BD
Kulkarni, PS
Marchetti, E
LaForce, FM
Preziosi, MP
AF Sow, Samba O.
Okoko, Brown J.
Diallo, Aldiouma
Viviani, Simonetta
Borrow, Ray
Carlone, George
Tapia, Milagritos
Akinsola, Adebayo K.
Arduin, Pascal
Findlow, Helen
Elie, Cheryl
Haidara, Fadima Cheick
Adegbola, Richard A.
Diop, Doudou
Parulekar, Varsha
Chaumont, Julie
Martellet, Lionel
Diallo, Fatoumata
Idoko, Olubukola T.
Tang, Yuxiao
Plikaytis, Brian D.
Kulkarni, Prasad S.
Marchetti, Elisa
LaForce, F. Marc
Preziosi, Marie-Pierre
TI Immunogenicity and Safety of a Meningococcal A Conjugate Vaccine in
Africans
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID NEISSERIA-MENINGITIDIS GROUP; POLYSACCHARIDE VACCINE; EPIDEMIC
MENINGITIS; SEROGROUP-A; ANTIBODY; MEMORY; TRIAL; BELT; RISK;
QUADRIVALENT
AB Background
Group A meningococci are the source of major epidemics of meningitis in Africa. An affordable, highly immunogenic meningococcal A conjugate vaccine is needed.
Methods
We conducted two studies in Africa to evaluate a new MenA conjugate vaccine (PsA-TT). In study A, 601 children, 12 to 23 months of age, were randomly assigned to receive PsA-TT, a quadrivalent polysaccharide reference vaccine (PsACWY), or a control vaccine (Haemophilus influenzae type b conjugate vaccine [Hib-TT]). Ten months later, these children underwent another round of randomization within each group to receive a full dose of PsA-TT, a one-fifth dose of PsACWY, or a full dose of Hib-TT, with 589 of the original participants receiving a booster dose. In study B, 900 subjects between 2 and 29 years of age were randomly assigned to receive PsA-TT or PsACWY. Safety and reactogenicity were evaluated, and immunogenicity was assessed by measuring the activity of group A serum bactericidal antibody (SBA) with rabbit complement and performing an IgG group A-specific enzyme-linked immunosorbent assay.
Results
In study A, 96.0% of the subjects in the PsA-TT group and 63.7% of those in the PsACWY group had SBA titers that were at least four times as high as those at baseline; in study B, 78.2% of the subjects in the PsA-TT group and 46.2% of those in the PsACWY group had SBA titers that were at least four times as high as those at baseline. The geometric mean SBA titers in the PsA-TT groups in studies A and B were greater by factors of 16 and 3, respectively, than they were in the PsACWY groups (P<0.001). In study A, the PsA-TT group had higher antibody titers at week 40 than the PsACWY group and had obvious immunologic memory after receiving a polysaccharide booster vaccine. Safety profiles were similar across vaccine groups, although PsA-TT recipients were more likely than PsACWY recipients to have tenderness and induration at the vaccination site. Adverse events were consistent with age-specific morbidity in the study areas; no serious vaccine-related adverse events were reported.
Conclusions
The PsA-TT vaccine elicited a stronger response to group A antibody than the PsACWY vaccine. (Funded by the Meningitis Vaccine Project through a grant from the Bill and Melinda Gates Foundation; Controlled-Trials.com numbers, ISRCTN78147026 and ISRCTN87739946.)
C1 [Sow, Samba O.; Tapia, Milagritos; Haidara, Fadima Cheick; Diallo, Fatoumata] Ctr Dev Vaccins, Bamako, Mali.
[Okoko, Brown J.; Akinsola, Adebayo K.; Adegbola, Richard A.; Idoko, Olubukola T.] MRC Labs, Basse, Gambia.
[Diallo, Aldiouma; Arduin, Pascal; Diop, Doudou] Inst Rech Dev, Dakar, Senegal.
[Viviani, Simonetta; Chaumont, Julie; Martellet, Lionel; Tang, Yuxiao; Marchetti, Elisa; LaForce, F. Marc] Program Appropriate Technol Hlth, Meningitis Vaccine Project, Ferney Voltaire, France.
[Borrow, Ray; Findlow, Helen] Hlth Protect Agcy NW, Vaccine Evaluat Unit, Manchester, Lancs, England.
[Carlone, George; Elie, Cheryl; Plikaytis, Brian D.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Parulekar, Varsha] DiagnoSearch Life Sci, Bombay, Maharashtra, India.
[Kulkarni, Prasad S.] Serum Inst India, Pune, Maharashtra, India.
[Preziosi, Marie-Pierre] WHO, Initiat Vaccine Res, Meningitis Vaccine Project, CH-1211 Geneva 27, Switzerland.
RP Preziosi, MP (reprint author), WHO, Initiat Vaccine Res, Meningitis Vaccine Project, 20 Ave Appia, CH-1211 Geneva 27, Switzerland.
EM preziosim@who.int
FU Bill and Melinda Gates Foundation
FX Supported by the Meningitis Vaccine Project (MVP) through a grant from
the Bill and Melinda Gates Foundation.
NR 37
TC 100
Z9 100
U1 0
U2 8
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD JUN 16
PY 2011
VL 364
IS 24
BP 2293
EP 2304
PG 12
WC Medicine, General & Internal
SC General & Internal Medicine
GA 777RZ
UT WOS:000291643800007
PM 21675889
ER
PT J
AU DeVries, AS
Harper, J
Murray, A
Lexau, C
Bahta, L
Christensen, J
Cebelinski, E
Fuller, S
Kline, S
Wallace, GS
Shaw, JH
Burns, CC
Lynfield, R
AF DeVries, Aaron S.
Harper, Jane
Murray, Andrew
Lexau, Catherine
Bahta, Lynn
Christensen, Jaime
Cebelinski, Elizabeth
Fuller, Susan
Kline, Susan
Wallace, Gregory S.
Shaw, Jing H.
Burns, Cara C.
Lynfield, Ruth
TI Vaccine-Derived Poliomyelitis 12 Years after Infection in Minnesota
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID POLIOVIRUS; ERADICATION; STRAIN
AB A 44-year-old woman with long-standing common variable immunodeficiency who was receiving intravenous immune globulin suddenly had paralysis of all four limbs and the respiratory muscles, resulting in death. Type 2 vaccine-derived poliovirus was isolated from stool. The viral capsid protein VP1 region had diverged from the vaccine strain at 12.3% of nucleotide positions, and the two attenuating substitutions had reverted to the wild-type sequence. Infection probably occurred 11.9 years earlier (95% confidence interval [CI], 10.9 to 13.2), when her child received the oral poliovirus vaccine. No secondary cases were identified among close contacts or 2038 screened health care workers. Patients with common variable immunodeficiency can be chronically infected with poliovirus, and poliomyelitis can develop despite treatment with intravenous immune globulin.
C1 [DeVries, Aaron S.; Harper, Jane; Murray, Andrew; Lexau, Catherine; Bahta, Lynn; Christensen, Jaime; Cebelinski, Elizabeth; Fuller, Susan; Lynfield, Ruth] Minnesota Dept Hlth, St Paul, MN 55164 USA.
[Kline, Susan] Univ Minnesota, Minneapolis, MN USA.
[Wallace, Gregory S.; Shaw, Jing H.; Burns, Cara C.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP DeVries, AS (reprint author), Minnesota Dept Hlth, POB 64975, St Paul, MN 55164 USA.
EM aaron.devries@state.mn.us
FU Centers for Disease Control and Prevention [3U01CI000313]
FX Supported in part by a grant (3U01CI000313) from the Emerging Infections
Program, Centers for Disease Control and Prevention.
NR 21
TC 35
Z9 37
U1 0
U2 1
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD JUN 16
PY 2011
VL 364
IS 24
BP 2316
EP 2323
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA 777RZ
UT WOS:000291643800009
PM 21675890
ER
PT J
AU Adler-Moore, J
Munoz, M
Kim, H
Romero, J
Tumpey, T
Zeng, H
Petro, C
Ernst, W
Kosina, S
Jimenez, G
Fujii, G
AF Adler-Moore, Jill
Munoz, Meilen
Kim, Hana
Romero, Juan
Tumpey, Terrence
Zeng, Hui
Petro, Chris
Ernst, William
Kosina, Suzie
Jimenez, Gretchen
Fujii, Gary
TI Characterization of the murine Th2 response to immunization with
liposomal M2e influenza vaccine
SO VACCINE
LA English
DT Article
DE Influenza virus; M2e; Liposomal vaccine; Anti-M2e antibodies; Cytokine
profile
ID A VIRUS; MONOCLONAL-ANTIBODY; MATRIX PROTEIN-2; EXTRACELLULAR DOMAIN;
DNA VACCINE; MICE; PROTECTION; CHALLENGE; REPLICATION; INFECTION
AB While the current influenza vaccine strategy is dependent on eliciting neutralizing antibodies to the hemagglutinin (Hot HA) surface glycoprotein, antigenic drifts and occasional antigenic shifts necessitate constant surveillance and annual updates to the vaccine components. The ectodomain of the matrix 2 (M2e) channel protein has been proposed as a universal vaccine candidate, although it has not yet been shown to elicit neutralizing antibodies. Utilizing a liposome-based vaccine technology, an M2e vaccine (L-M2e-HD/MPL) was tested and shown to stimulate the production of anti-M2e antibodies which precipitated with whole virus and inhibited viral cell lysis by multiple type A strains of influenza virus using a novel in vitro assay. The anti-M2e antibodies also conferred complete protection following passive transfer from L-M2e-HD/MPL vaccinated mice to naive mice challenged with HI NI virus. Significantly higher levels of IL-4 compared to IFN-gamma were secreted by the splenocytes of L-M2e-HD/MPL vaccinated mice incubated with M2e. In addition, depletion of CD4 cells or CD4 cells plus CD8 cells from L-M2e-HD/MPL vaccinated mice using monoclonal antibodies markedly decreased the level of protection of the vaccine when compared to just CD8 depletion of L-M2e-HD/MPL vaccinated mice. These results suggest that the protective immune response elicited by this vaccine is mediated primarily by a Th2 mechanism. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Adler-Moore, Jill] Calif State Polytech Univ Pomona, Dept Biol Sci, Pomona, CA 91768 USA.
[Tumpey, Terrence; Zeng, Hui] Ctr Dis Control & Prevent, Influenza Branch, Atlanta, GA 30333 USA.
[Ernst, William; Kosina, Suzie; Jimenez, Gretchen; Fujii, Gary] Mol Express Inc, Rancho Dominguez, CA 90220 USA.
RP Adler-Moore, J (reprint author), Calif State Polytech Univ Pomona, Dept Biol Sci, 3801 W Temple Ave, Pomona, CA 91768 USA.
EM jpadler@csupomona.edu
RI Kosina, Suzanne/I-5331-2016
OI Kosina, Suzanne/0000-0003-2885-1248
FU NIH [U01AI074508, R43AI078654]; California State University Agricultural
Research Initiative
FX This work was partially supported by grants from: NIH - U01AI074508
(PI-Fujii); NIH - R43AI078654 (PI-Fujii); California State University
Agricultural Research Initiative (PI-Adler-Moore).
NR 25
TC 7
Z9 7
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD JUN 15
PY 2011
VL 29
IS 27
BP 4460
EP 4468
DI 10.1016/j.vaccine.2011.04.040
PG 9
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 792DN
UT WOS:000292720800005
PM 21545821
ER
PT J
AU Pierce, CL
Williams, TL
Moura, H
Pirkle, JL
Cox, NJ
Stevens, J
Donis, RO
Barr, JR
AF Pierce, Carrie L.
Williams, Tracie L.
Moura, Hercules
Pirkle, James L.
Cox, Nancy J.
Stevens, James
Donis, Ruben O.
Barr, John R.
TI Quantification of Immunoreactive Viral Influenza Proteins by
Immunoaffinity Capture and Isotope-Dilution Liquid Chromatography-Tandem
Mass Spectrometry
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID SINGLE-RADIAL-IMMUNODIFFUSION; LETHAL FACTOR; WHOLE VIRUS;
HEMAGGLUTININ; VACCINES; ASSAY; ANTIBODY; SURFACTANT; DIGESTION; ANTHRAX
AB An immunocapture isotope dilution mass spectrometry (IC-IDMS) method was developed to quantify antibody-bound influenza hemagglutinins (HA) in trivalent influenza vaccines (TIV). Currently, regulatory potency requirements for TIV require HA quantification based on the single radial immunodiffusion (SRID) assay, which is time-consuming, laborious, and requires production of large quantities of reagents globally. In IC-IDMS, antiserum to the HA of interest captured viral proteins that were in the correct conformation to be recognized by the antibodies. The captured proteins were digested, and evolutionarily conserved tryptic peptides were quantified using isotope-dilution liquid chromatography-tandem mass spectrometry. IC-IDMS relies on antibody-antigen binding similar to SRID but incorporates the accuracy and precision of IDMS. Polyclonal antibodies (pAb-H3) prepared by injection of sheep with purified H3 HA captured 82.9% (55.26 fmol/mu L) of the total H3 HA (66.69 fmol/mu L) from the commercial TIV and 93.6% (57.23 fmol/mu L) of the total H3 HA (61.14 fmol/mu L) in purified virus. While other HA (H1, B), neuraminidase (N1, N2, NB), viral matrix proteins, and nucleoproteins were also captured by this antiserum, our results were not affected due to the specificity of the mass spectrometer. IC-IDMS is an accurate, precise, sensitive, and selective method to measure antibody-bound HA in purified virus and commercial vaccines.
C1 [Pierce, Carrie L.; Williams, Tracie L.; Moura, Hercules; Pirkle, James L.; Barr, John R.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Cox, Nancy J.; Stevens, James; Donis, Ruben O.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Infect Dis, Atlanta, GA 30333 USA.
RP Barr, JR (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway,MS F-50, Atlanta, GA 30341 USA.
EM JBarr@cdc.gov
NR 27
TC 11
Z9 13
U1 1
U2 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
J9 ANAL CHEM
JI Anal. Chem.
PD JUN 15
PY 2011
VL 83
IS 12
BP 4729
EP 4737
DI 10.1021/ac2006526
PG 9
WC Chemistry, Analytical
SC Chemistry
GA 775YP
UT WOS:000291499800020
PM 21591780
ER
PT J
AU Sharma, K
Tripathi, S
Ranjan, P
Kumar, P
Garten, R
Deyde, V
Katz, JM
Cox, NJ
Lal, RB
Sambhara, S
Lal, SK
AF Sharma, Kulbhushan
Tripathi, Shashank
Ranjan, Priya
Kumar, Purnima
Garten, Rebecca
Deyde, Varough
Katz, Jacqueline M.
Cox, Nancy J.
Lal, Renu B.
Sambhara, Suryaprakash
Lal, Sunil K.
TI Influenza A Virus Nucleoprotein Exploits Hsp40 to Inhibit PKR Activation
SO PLOS ONE
LA English
DT Article
ID DEPENDENT PROTEIN-KINASE; KAPPA-B KINASE; NS1 PROTEIN; CELLULAR
INHIBITOR; CHAPERONE FUNCTION; INITIATION-FACTOR; NUCLEAR EXPORT; RNA;
INTERFERON; REPLICATION
AB Background: Double-stranded RNA dependent protein kinase (PKR) is a key regulator of the anti-viral innate immune response in mammalian cells. PKR activity is regulated by a 58 kilo Dalton cellular inhibitor (P58(IPK)), which is present in inactive state as a complex with Hsp40 under normal conditions. In case of influenza A virus (IAV) infection, P58(IPK) is known to dissociate from Hsp40 and inhibit PKR activation. However the influenza virus component responsible for PKR inhibition through P58(IPK) activation was hitherto unknown.
Principal Findings: Human heat shock 40 protein (Hsp40) was identified as an interacting partner of Influenza A virus nucleoprotein (IAV NP) using a yeast two-hybrid screen. This interaction was confirmed by co-immunoprecipitation studies from mammalian cells transfected with IAV NP expressing plasmid. Further, the IAV NP-Hsp40 interaction was validated in mammalian cells infected with various seasonal and pandemic strains of influenza viruses. Cellular localization studies showed that NP and Hsp40 co-localize primarily in the nucleus. During IAV infection in mammalian cells, expression of NP coincided with the dissociation of P58(IPK) from Hsp40 and decrease PKR phosphorylation. We observed that, plasmid based expression of NP in mammalian cells leads to decrease in PKR phosphorylation. Furthermore, inhibition of NP expression during influenza virus replication led to PKR activation and concomitant increase in eIF2 alpha phosphorylation. Inhibition of NP expression also led to reduced IRF3 phosphorylation, enhanced IFN beta production and concomitant reduction of virus replication. Taken together our data suggest that NP is the viral factor responsible for P58(IPK) activation and subsequent inhibition of PKR-mediated host response during IAV infection.
Significance: Our findings demonstrate a novel role of IAV NP in inhibiting PKR-mediated anti-viral host response and help us understand P58(IPK) mediated inhibition of PKR activity during IAV infection.
C1 [Sharma, Kulbhushan; Tripathi, Shashank; Kumar, Purnima; Lal, Sunil K.] Int Ctr Genet Engn & Biotechnol, Virol Grp, New Delhi, India.
[Ranjan, Priya; Garten, Rebecca; Deyde, Varough; Katz, Jacqueline M.; Cox, Nancy J.; Lal, Renu B.; Sambhara, Suryaprakash] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
RP Sharma, K (reprint author), Int Ctr Genet Engn & Biotechnol, Virol Grp, New Delhi, India.
EM sunillal@icgeb.res.in
OI Tripp, Ralph/0000-0002-2924-9956
FU ICGEB (International Centre for Genetic Engineering Biotechnology);
Department of Biotechnology, Government of India; Centre for Disease
Control (CDC), Atlanta
FX This work was supported by internal funds from ICGEB (International
Centre for Genetic Engineering & Biotechnology), a grant from the
Department of Biotechnology, Government of India and a training grant
from the Centre for Disease Control (CDC), Atlanta. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 54
TC 27
Z9 30
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 15
PY 2011
VL 6
IS 6
AR e20215
DI 10.1371/journal.pone.0020215
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 778TS
UT WOS:000291730000009
PM 21698289
ER
PT J
AU Morgan, MK
Jones, PA
Calafat, AM
Ye, XY
Croghan, CW
Chuang, JC
Wilson, NK
Clifton, MS
Figueroa, Z
Sheldon, LS
AF Morgan, Marsha K.
Jones, Paul A.
Calafat, Antonia M.
Ye, Xiaoyun
Croghan, Carry W.
Chuang, Jane C.
Wilson, Nancy K.
Clifton, Matthew S.
Figueroa, Zaida
Sheldon, Linda S.
TI Assessing the Quantitative Relationships between Preschool Children's
Exposures to Bisphenol A by Route and Urinary Biomonitoring
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID PERSISTENT ORGANIC POLLUTANTS; DAY-CARE; AGGREGATE EXPOSURES; US
POPULATION; UNITED-STATES; CANNED FOODS; PHENOLS; RISK; BPA; MIGRATION
AB Limited published information exists on young children's exposures to bisphenol A (BPA) in the United States using urinary biomonitoring. In a previous project, we quantified the aggregate exposures of 257 preschool children to BPA in environmental and personal media over 48-h periods in 2000-2001 at homes and daycares in North Carolina and Ohio. In the present study for 81 Ohio preschool children ages 23-64 months, we quantified the children's urinary total BPA (free and conjugated) concentrations over these same 48-h periods in 2001. Then, we examined the quantitative relationships between the children's intakes doses of BPA through the dietary ingestion, nondietary ingestion, and inhalation routes and their excreted amounts of urinary BPA. BPA was detected in 100% of the urine samples. The estimated median intake doses of BPA for these 81 children were 109 ng/kg/day (dietary ingestion), 0.06 ng/kg/day (nondietary ingestion), and 0.27 ng/kg/day (inhalation); their estimated median excreted amount of urinary BPA was 114 ng/kg/day. Our multivariable regression model showed that dietary intake of BPA (p = 0.04) and creatinine concentration (p = 0.004) were significant predictors of urinary BPA excretion, collectively explaining 17% of the variability in excretion. Dietary ingestion of BPA accounted for >95% of the children's excreted amounts of urinary BPA.
C1 [Morgan, Marsha K.; Jones, Paul A.; Croghan, Carry W.; Clifton, Matthew S.; Sheldon, Linda S.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27713 USA.
[Calafat, Antonia M.; Ye, Xiaoyun] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
[Chuang, Jane C.] Battelle Mem Inst, Columbus, OH 43201 USA.
[Wilson, Nancy K.] Battelle Mem Inst, Durham, NC 27713 USA.
[Figueroa, Zaida] US EPA, Off Pesticide Programs, Washington, DC 20460 USA.
RP Morgan, MK (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27713 USA.
EM morgan.marsha@epa.gov
FU United States Environmental Protection Agency through its Office of
Research and Development [68-D-99-011]
FX We thank Amber Bishop and Jack Reidy for the measurements of BPA. The
findings and conclusions in this report are those of the authors and do
not necessarily represent the views of the CDC. Predisclaimer: The
United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research described here
under Contract #68-D-99-011 to Battelle. It has been subjected to Agency
review and approved for publication.
NR 43
TC 41
Z9 42
U1 0
U2 17
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JUN 15
PY 2011
VL 45
IS 12
BP 5309
EP 5316
DI 10.1021/es200537u
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 774YH
UT WOS:000291422200037
PM 21612268
ER
PT J
AU Hootman, JM
Helmick, CG
Hannan, CJ
Pan, LP
AF Hootman, Jennifer M.
Helmick, Charles G.
Hannan, Casey J.
Pan, Liping
TI Prevalence of Obesity Among Adults With Arthritis-United States,
2003-2009 (Reprinted from MMWR, vol 60, pg 509-513, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Hootman, Jennifer M.; Helmick, Charles G.; Hannan, Casey J.] CDC, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
[Pan, Liping] CDC, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
RP Hootman, JM (reprint author), CDC, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
EM jhootman@cdc.gov
NR 1
TC 0
Z9 0
U1 1
U2 2
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 15
PY 2011
VL 305
IS 23
BP 2404
EP 2405
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 777EB
UT WOS:000291597300009
ER
PT J
AU Tiwari, T
Clark, TA
Messonnier, NE
Thomas, CG
AF Tiwari, T.
Clark, T. A.
Messonnier, N. E.
Thomas, C. G.
TI Tetanus Surveillance-United States, 2001-2008 (Reprinted from MMWR, vol
60, pg 365-369, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Tiwari, T.; Clark, T. A.; Messonnier, N. E.] CDC, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Thomas, C. G.] CDC, EIS, Atlanta, GA 30333 USA.
RP Tiwari, T (reprint author), CDC, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
EM ttiwari@cdc.gov
NR 1
TC 0
Z9 0
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 15
PY 2011
VL 305
IS 23
BP 2406
EP 2408
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 777EB
UT WOS:000291597300010
ER
PT J
AU Green, MK
Harrison, R
Leinenkugel, K
Nguyen, CB
Towle, M
Schoonover, T
Bunn, T
Northwood, J
Pratt, SG
Myers, JR
AF Green, Mandy K.
Harrison, Robert
Leinenkugel, Kathy
Nguyen, Claire B.
Towle, Meredith
Schoonover, Todd
Bunn, Terry
Northwood, Joyce
Pratt, Stephanie G.
Myers, John R.
TI Occupational Highway Transportation Deaths-United States, 2003-2008
(Reprinted from MMWR, vol 60, pg 497-502, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
ID CRASHES
C1 [Pratt, Stephanie G.; Myers, John R.] NIOSH, Div Safety Res, CDC, Washington, DC USA.
[Nguyen, Claire B.] Oklahoma Dept Hlth, Oklahoma City, OK 73117 USA.
[Schoonover, Todd] Washington State Dept Labor & Ind, Olympia, WA 98504 USA.
[Bunn, Terry] Univ Kentucky, Lexington, KY 40506 USA.
[Northwood, Joyce] US Bur Labor Stat, US Dept Labor, Washington, DC 20212 USA.
RP Myers, JR (reprint author), NIOSH, Div Safety Res, CDC, Washington, DC USA.
EM jrmyers@cdc.gov
NR 11
TC 1
Z9 1
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 15
PY 2011
VL 305
IS 23
BP 2408
EP 2410
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 777EB
UT WOS:000291597300011
ER
PT J
AU Ahmed, R
Buckland, M
Davies, L
Halmagyi, GM
Rogers, SL
Oberste, S
Barnett, MH
AF Ahmed, Rebekah
Buckland, Michael
Davies, Leo
Halmagyi, G. Michael
Rogers, Shannon L.
Oberste, Steven
Barnett, Michael H.
TI Enterovirus 71 meningoencephalitis complicating rituximab therapy
SO JOURNAL OF THE NEUROLOGICAL SCIENCES
LA English
DT Article
DE Enterovirus 71; Encephalitis; Rituximab; Monoclonal antibody
ID ANTI-CD20 MONOCLONAL-ANTIBODY; DIRECT IDENTIFICATION; AMPLIFICATION;
SEROTYPES; LYMPHOMA
AB We describe a fatal case of proven enterovirus 71 meningoencephalitis complicating monoclonal anti-CD20 antibody therapy for non-Hodgkin's lymphoma. B-cell depletion, an effective treatment strategy in an expanding spectrum of hematological and inflammatory disorders, impairs neutralising antibody-mediated clearance of enterovirus. The global threat of emerging neurotropic viruses such as enterovirus 71 is heightened by an increasing pool of susceptible individuals in non-endemic regions. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Ahmed, Rebekah; Davies, Leo; Halmagyi, G. Michael; Barnett, Michael H.] Univ Sydney, Royal Prince Alfred Hosp, Inst Clin Neurosci, Sydney, NSW 2006, Australia.
[Buckland, Michael] Royal Prince Alfred Hosp, Dept Neuropathol, Sydney, NSW, Australia.
[Rogers, Shannon L.; Oberste, Steven] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Barnett, MH (reprint author), Brain & Mind Res Inst, Lvl 4,94 Mallett St, Camperdown, NSW 2050, Australia.
EM mbarnett@mail.usyd.edu.au
NR 12
TC 6
Z9 6
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-510X
J9 J NEUROL SCI
JI J. Neurol. Sci.
PD JUN 15
PY 2011
VL 305
IS 1-2
BP 149
EP 151
DI 10.1016/j.jns.2011.03.009
PG 3
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 773SN
UT WOS:000291330800028
PM 21444094
ER
PT J
AU Bishop, AM
Fernandez, C
Whitehead, RD
Morales, P
Barr, DB
Wilder, LC
Baker, SE
AF Bishop, Amanda M.
Fernandez, Carolina
Whitehead, Ralph D., Jr.
Morales-A, Pilar
Barr, Dana Boyd
Wilder, Lynn C.
Baker, Samuel E.
TI Quantification of riboflavin in human urine using high performance
liquid chromatography-tandem mass spectrometry
SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL
AND LIFE SCIENCES
LA English
DT Article
DE Riboflavin; Human urine; Surrogate; HPLC-MS/MS
AB We developed a selective method to measure riboflavin in human urine. Sample preparation involved solid phase extraction and concentration of the target analyte in urine. The urine concentrate was analyzed using high performance liquid chromatography-tandem mass spectrometry. Riboflavin concentrations were quantified using an isotopically labeled internal standard. The limit of detection was 11 ng/mL, and the linear range was 4.4-20,000 ng/mL. The relative standard deviation at 100, 1000, and 5000 ng/mL was 17%, 17%, and 12%. respectively. The accuracy was 90%. On average, 100 samples, including calibration standards and quality control samples, were prepared per day. Using our method, we measured concentrations of riboflavin in human urine samples that were collected from participants in a study where riboflavin was used as a surrogate chemical to simulate exposure to an environmental toxicant. Published by Elsevier B.V.
C1 [Bishop, Amanda M.; Fernandez, Carolina; Whitehead, Ralph D., Jr.; Morales-A, Pilar; Baker, Samuel E.] Ctr Dis Control & Prevent, Natl Ctr Environm Health, Div Sci Lab, Atlanta, GA 30341 USA.
[Bishop, Amanda M.; Fernandez, Carolina; Morales-A, Pilar] Battelle Mem Inst, Atlanta, GA 30329 USA.
[Wilder, Lynn C.] Agcy Toxic Subst Dis Registry, Div Hlth Studies, Atlanta, GA 30341 USA.
[Barr, Dana Boyd] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
RP Baker, SE (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Health, Div Sci Lab, 4770 Buford Highway,MS F-17, Atlanta, GA 30341 USA.
EM sab6@cdc.gov
RI Barr, Dana/E-6369-2011; Barr, Dana/E-2276-2013
NR 16
TC 6
Z9 6
U1 2
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1570-0232
J9 J CHROMATOGR B
JI J. Chromatogr. B
PD JUN 15
PY 2011
VL 879
IS 20
BP 1823
EP 1826
DI 10.1016/j.jchromb.2011.04.032
PG 4
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 784RY
UT WOS:000292177100016
PM 21612990
ER
PT J
AU Schieltz, DM
McGrath, SC
McWilliams, LG
Rees, J
Bowen, MD
Kools, JJ
Dauphin, LA
Gomez-Saladin, E
Newton, BN
Stang, HL
Vick, MJ
Thomas, J
Pirkle, JL
Barr, JR
AF Schieltz, David M.
McGrath, Sara C.
McWilliams, Lisa G.
Rees, Jon
Bowen, Michael D.
Kools, John J.
Dauphin, Leslie A.
Gomez-Saladin, Eduardo
Newton, Bruce N.
Stang, Heather L.
Vick, Michael J.
Thomas, Jerry
Pirkle, James L.
Barr, John R.
TI Analysis of active ricin and castor bean proteins in a ricin
preparation, castor bean extract, and surface swabs from a public health
investigation
SO FORENSIC SCIENCE INTERNATIONAL
LA English
DT Article
DE Ricin; RCA120; Mass spectrometry; Database search; Proteomic analysis
ID BIOLOGICAL WARFARE AGENTS; TANDEM MASS-SPECTROMETRY; N-GLYCOSIDASE
ACTIVITY; FORENSIC IDENTIFICATION; STATISTICAL-MODEL; A-CHAIN; MS/MS;
RNA; IMMUNOAFFINITY; MECHANISM
AB In late February 2008, law enforcement officials in Las Vegas, Nevada, discovered in a hotel room, a copy of The Anarchist Cookbook, suspected castor beans and a "white powder" thought to be a preparation of ricin. Ricin is a deadly toxin from the seed of the castor bean plant (Ricinus communis). The United States regulates the possession, use, and transfer of ricin and it is the only substance considered a warfare agent in both the Chemical and the Biological Weapons Conventions. Six samples obtained from the hotel room were analyzed by laboratories at the Centers for Disease Control and Prevention using a panel of biological and mass spectrometric assays. The biological assays (real time-PCR, time resolved fluorescence and cytotoxicity) provided presumptive evidence of active ricin in each of the samples. This initial screen was followed by an in-depth analysis using a novel, state-of-the-art mass spectrometry-based ricin functional assay and high sensitivity tandem mass spectrometry for protein identification. Mass spectrometric analysis positively identified ricin and confirmed that in each of the samples it was enzymatically active.
The tandem mass spectrometry analysis used here is the most selective method available to detect ricin toxin. In each sample, ricin was unequivocally identified along with other R. communis plant proteins, including the highly homologous protein RCA120. Although database searches using tandem mass spectra acquired from the samples indicated that additional controlled substances were not present in these samples, the mass spectrometric results did provide extensive detail about the sample contents. To the best of our knowledge following a review of the available literature, this report describes the most detailed analysis of a white powder for a public health or forensic investigation involving ricin. Published by Elsevier Ireland Ltd.
C1 [Schieltz, David M.; McGrath, Sara C.; Rees, Jon; Thomas, Jerry; Pirkle, James L.; Barr, John R.] Ctr Dis Control & Prevent, Emergency Response & Air Toxicants Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[McWilliams, Lisa G.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA.
[Bowen, Michael D.; Kools, John J.; Dauphin, Leslie A.; Gomez-Saladin, Eduardo; Newton, Bruce N.; Stang, Heather L.; Vick, Michael J.] Ctr Dis Control & Prevent, Bioterrorism Rapid Response & Adv Technol Lab, Div Bioterrorism Preparedness & Response, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA.
RP Barr, JR (reprint author), Ctr Dis Control & Prevent, Emergency Response & Air Toxicants Branch, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway NE,MS-F50, Atlanta, GA 30341 USA.
EM jbarr@cdc.gov
OI McGrath, Sara/0000-0003-4773-4784
NR 32
TC 22
Z9 22
U1 3
U2 27
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0379-0738
J9 FORENSIC SCI INT
JI Forensic Sci.Int.
PD JUN 15
PY 2011
VL 209
IS 1-3
BP 70
EP 79
DI 10.1016/j.forsciint.2010.12.013
PG 10
WC Medicine, Legal
SC Legal Medicine
GA 769QU
UT WOS:000291034100020
PM 21251774
ER
PT J
AU Finelli, L
Chaves, SS
AF Finelli, Lyn
Chaves, Sandra S.
TI Influenza and Acute Myocardial Infarction
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Editorial Material
ID RESPIRATORY SYNCYTIAL VIRUS; ACUTE CORONARY SYNDROMES; UNITED-STATES;
REDUCED RISK; VACCINATION; MORTALITY; ASSOCIATION; EPIDEMIC; DISEASE;
EVENTS
C1 [Finelli, Lyn; Chaves, Sandra S.] Natl Ctr Immunizat & Resp Dis, Influenza Div, Ctr Dis Control & Prevent, Epidemiol & Prevent Branch, Atlanta, GA 30333 USA.
RP Finelli, L (reprint author), Natl Ctr Immunizat & Resp Dis, Influenza Div, Ctr Dis Control & Prevent, Epidemiol & Prevent Branch, 1600 Clifton Rd NE,MS A 32, Atlanta, GA 30333 USA.
EM lyf8@cdc.gov
NR 45
TC 6
Z9 7
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD JUN 15
PY 2011
VL 203
IS 12
BP 1701
EP +
DI 10.1093/infdis/jir175
PG 4
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 770BO
UT WOS:000291062200001
PM 21606526
ER
PT J
AU Chase, AJ
Medina, FA
Munoz-Jordan, JL
AF Chase, Amanda J.
Medina, Freddy A.
Munoz-Jordan, Jorge L.
TI Impairment of CD4(+) T Cell Polarization by Dengue Virus-Infected
Dendritic Cells
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID INTERFERON-ALPHA; FLOW-CYTOMETRY; CAPSID PROTEIN; I INTERFERON; DC-SIGN;
VACCINE; RESPONSES; FEVER; TRANSMISSION; REPLICATION
AB Methods. In order to ascertain the stimulatory capacity of primary human monocyte-derived DCs infected with wild-type DENV isolates, representing a range of genotypes and disease outcomes, we cocultured infected DCs with allogeneic-naive CD4(+) T cells. The gene expression patterns of IFN-alpha/beta sensitive genes were quantitated to determine if the infected DCs displayed a blunted IFN-alpha/beta response.
Results. DENV-infected DCs induced the initial proliferation of naive CD4(+) T cells but they remained nonpolarized in effector function. The expression of IFN-alpha/beta-stimulated genes was downregulated, revealing that the inhibition of IFN-alpha/beta signaling is conserved among endemic DENV serotype 2 strains.
Conclusions. The failure of naive CD4(+) T cells to differentiate into IFN gamma-producing effector T cells when primed by DENV-infected DCs cannot be explained solely by a block in IFN-alpha/beta signaling, suggesting that the ability of DENV to evade the early host response is multifaceted.
C1 [Medina, Freddy A.; Munoz-Jordan, Jorge L.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Dengue Branch, San Juan, PR USA.
[Chase, Amanda J.] Georgia Coll, Dept Biol & Environm Sci, Milledgeville, GA 31061 USA.
[Chase, Amanda J.] State Univ, Milledgeville, GA USA.
RP Munoz-Jordan, JL (reprint author), CDC Dengue Branch, Mol Diagnost & Res Lab, 1324 Canada St, San Juan, PR 00920 USA.
EM ckq2@cdc.gov
FU Centers for Disease Control and Prevention (CDC); U.S. Department of
Energy and CDC
FX This research was supported in part by an appointment (A. J. C.) to the
Emerging Infectious Diseases (EID) Fellowship Program administered by
the Association of Public Health Laboratories (APHL) and funded by the
Centers for Disease Control and Prevention (CDC), and an appointment (F.
A. M. and A. J. C.) to the Research Participation Program at the CDC
administered by the Oak Ridge Institute for Science and Education
(ORISE) through an interagency agreement between the U.S. Department of
Energy and CDC. The opinions expressed are those of the authors and do
not represent the official views of the CDC, APHL, or ORISE.
NR 46
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U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD JUN 15
PY 2011
VL 203
IS 12
BP 1763
EP 1774
DI 10.1093/infdis/jir197
PG 12
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 770BO
UT WOS:000291062200010
PM 21606535
ER
PT J
AU Honore, PA
Fos, PJ
Wang, XY
Moonesinghe, R
AF Honore, Peggy A.
Fos, Peter J.
Wang, Xueyuan
Moonesinghe, Ramal
TI The effects on population health status of using dedicated property
taxes to fund local public health agencies
SO BMC PUBLIC HEALTH
LA English
DT Article
AB Background: In the United States, a dedicated property tax describes the legal authority given to a local jurisdiction to levy and collect a tax for a specific purpose. We investigated for an association of locally dedicated property taxes to fund local public health agencies and improved health status in the eight states designated as the Mississippi Delta Region.
Methods: We analyzed the difference in health outcomes of counties with and without a dedicated public health tax after adjusting for a set of control variables using regression models for county level data from 720 counties of the Mississippi Delta Region.
Results: Levying a dedicated public health tax for counties with per capita income above $28,000 is associated with improved health outcomes of those counties when compared to counties without a dedicated property tax for public health. Alternatively, levying a dedicated property tax in counties with lower per capita income is associated with poor health outcomes.
Conclusions: There are both positive and negative consequences of using dedicated property taxes to fund public health. Policymakers should carefully examine both the positive association of improved health outcomes and negative impact of taxation on poor populations before authorizing the use of dedicated local property tax levies to fund public health agencies.
C1 [Honore, Peggy A.; Wang, Xueyuan] Univ So Mississippi, Dept Community Hlth Sci, Hattiesburg, MS 39406 USA.
[Fos, Peter J.] Louisiana State Univ, Hlth Sci Ctr, Hlth Policy & Syst Management Program, Sch Publ Hlth, New Orleans, LA 70112 USA.
[Moonesinghe, Ramal] Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Dispar, Atlanta, GA 30333 USA.
RP Honore, PA (reprint author), Univ So Mississippi, Dept Community Hlth Sci, 118 Coll Dr, Hattiesburg, MS 39406 USA.
EM peggy.honore@usm.edu
FU Robert Wood Johnson Foundation
FX This study was funded with support to the University of Southern
Mississippi from the Robert Wood Johnson Foundation.
NR 19
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U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 14
PY 2011
VL 11
AR 471
DI 10.1186/1471-2458-11-471
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 796AY
UT WOS:000293023800001
PM 21672231
ER
PT J
AU Gurley, ES
Parveen, S
Islam, MS
Hossain, MJ
Nahar, N
Homaira, N
Sultana, R
Sejvar, JJ
Rahman, M
Luby, SP
AF Gurley, Emily S.
Parveen, Shahana
Islam, M. Saiful
Hossain, M. Jahangir
Nahar, Nazmun
Homaira, Nusrat
Sultana, Rebeca
Sejvar, James J.
Rahman, Mahmudur
Luby, Stephen P.
TI Family and community concerns about post-mortem needle biopsies in a
Muslim society
SO BMC MEDICAL ETHICS
LA English
DT Article
DE post-mortem; Bangladesh; needle biopsy; outbreak; diagnosis; informed
consent
ID INVASIVE PNEUMOCOCCAL DISEASE; TO-PERSON TRANSMISSION; RURAL BANGLADESH;
CHILDHOOD DEATHS; INFORMED-CONSENT; VIRUS-INFECTION; CARE-SEEKING; NIPAH
VIRUS; PNEUMONIAE INFECTION; CLINICAL SPECIMENS
AB Background: Post-mortem needle biopsies have been used in resource-poor settings to determine cause of death and there is interest in using them in Bangladesh. However, we did not know how families and communities would perceive this procedure or how they would decide whether or not to consent to a post-mortem needle biopsy. The goal of this study was to better understand family and community concerns and decision-making about post-mortem needle biopsies in this low-income, predominantly Muslim country in order to design an informed consent process.
Methods: We conducted 16 group discussions with family members of persons who died during an outbreak of Nipah virus illness during 2004-2008 and 11 key informant interviews with their community and religious leaders. Qualitative researchers first described the post-mortem needle biopsy procedure and asked participants whether they would have agreed to this procedure during the outbreak. Researchers probed participants about the circumstances under which the procedure would be acceptable, if any, their concerns about the procedure, and how they would decide whether or not to consent to the procedure.
Results: Overall, most participants agreed that post-mortem needle biopsies would be acceptable in some situations, particularly if they benefitted society. This procedure was deemed more acceptable than full autopsy because it would not require major delays in burial or remove organs, and did not require cutting or stitching of the body. It could be performed before the ritual bathing of the body in either the community or hospital setting. However, before consent would be granted for such a procedure, the research team must gain the trust of the family and community which could be difficult. Although consent may only be provided by the guardians of the body, decisions about consent for the procedure would involve extended family and community and religious leaders.
Conclusions: The possible acceptability of this procedure during outbreaks represents an important opportunity to better characterize cause of death in Bangladesh which could lead to improved public health interventions to prevent these deaths. Obstacles for research teams will include engaging all major stakeholders in decision-making and quickly building a trusting relationship with the family and community, which will be difficult given the short window of time prior to the ritual bathing of the body.
C1 [Gurley, Emily S.; Parveen, Shahana; Islam, M. Saiful; Hossain, M. Jahangir; Nahar, Nazmun; Homaira, Nusrat; Sultana, Rebeca; Luby, Stephen P.] Bangladesh ICDDR B, Int Ctr Diarrheal Dis Res, Dhaka 1000, Bangladesh.
[Sejvar, James J.; Luby, Stephen P.] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA 30333 USA.
[Rahman, Mahmudur] Govt Bangladesh, Inst Epidemiol Dis Control & Res IEDCR, Minist Hlth & Family Welf, Dhaka 1000, Bangladesh.
RP Gurley, ES (reprint author), Bangladesh ICDDR B, Int Ctr Diarrheal Dis Res, GPO 128, Dhaka 1000, Bangladesh.
EM egurley@icddrb.org
RI Gurley, Emily/B-7903-2010
OI Gurley, Emily/0000-0002-8648-9403
FU Centers for Disease Control and Prevention (CDC) [5U51CI000298-05]
FX This research protocol was funded by Centers for Disease Control and
Prevention (CDC), grant number_5U51CI000298-05. ICDDR, B acknowledges
with gratitude the commitment of CDC to the Centre's research efforts.
We thank Nasrin Akter, Momtaz Begum, Dawlat Khan, Mahbub -Ul Alam, Tania
Naushin, and N.M. Rabiul Awal Chowdhury for their hard work in
collecting and processing data for this study. We are indebted to the
families and community and religious leaders who gave us their valuable
time and attention.
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U2 10
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1472-6939
J9 BMC MED ETHICS
JI BMC Med. Ethics
PD JUN 13
PY 2011
VL 12
AR 10
DI 10.1186/1472-6939-12-10
PG 11
WC Ethics; Medical Ethics; Social Sciences, Biomedical
SC Social Sciences - Other Topics; Medical Ethics; Biomedical Social
Sciences
GA 793NX
UT WOS:000292831500001
PM 21668979
ER
PT J
AU Zahner, D
Gandhi, AR
Stuchlik, O
Reed, M
Pohl, J
Stephens, DS
AF Zaehner, Dorothea
Gandhi, Ashish R.
Stuchlik, Olga
Reed, Matthew
Pohl, Jan
Stephens, David S.
TI Pilus backbone protein PitB of Streptococcus pneumoniae contains
stabilizing intramolecular isopeptide bonds
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Fimbrial protein; Intramolecular cross-link; Proteolytic stability;
Thermal stability; Mass spectrometry
ID CORYNEBACTERIUM-DIPHTHERIAE; SURFACE PROTEIN; CELL-WALL; PYOGENES;
ADHESION; LINKAGE; REGION; DOMAIN; M3
AB Streptococcus pneumoniae type 2 pili are recently identified fimbrial structures extending from the bacterial surface and formed by polymers of the structural protein PitB. Intramolecular isopeptide bonds are a characteristic of the related pilus backbone protein Spy0128 of group A streptococci. Based on the identification of conserved residues in PitB, we predicted two intramolecular isopeptide bonds in PitB. Using a combination of tandem mass spectrometry and Edman sequencing, we show that these bonds were formed between Lys(63)-Asn(214) and Lys(243)-Asn(372) in PitB. Mutant proteins lacking the intramolecular isopeptide bonds retained the proteolytic stability observed with the wild type protein. However, absence of these bonds substantially decreased the melting temperature of the PitB-derivatives, indicating a stabilizing function of these bonds in PitB of the pneumococcal type 2 pilus. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Zaehner, Dorothea; Gandhi, Ashish R.; Stephens, David S.] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA.
[Stephens, David S.] Emory Univ, Sch Med, Rollins Res Ctr, Dept Microbiol & Immunol, Atlanta, GA 30322 USA.
[Stuchlik, Olga; Reed, Matthew; Pohl, Jan] Ctr Dis Control & Prevent, Biotechnol Core Facil Branch, Atlanta, GA 30329 USA.
[Zaehner, Dorothea; Stephens, David S.] Dept Vet Affairs Med Ctr Atlanta, Decatur, GA 30033 USA.
RP Zahner, D (reprint author), VA Med Ctr Atlanta, Res Serv 151, 1670 Clairmont Rd, Decatur, GA 30033 USA.
EM dzahner@emory.edu
RI Stephens, David/A-8788-2012
FU NIH [R01AI 070829]; Dept. of Veterans Affairs
FX We thank Dr. Christian Klein (Bruker Daltonics) for his help with
interpretation of ESI-MS/MS data of the crosslinks and Dr. Fred Strobel
of the Department of Chemistry (Emory University) for exact mass
determinations by ESI MS. This work was supported by funds from NIH
Grant #R01AI 070829 (DSS) and a VA Merit Award from the Dept. of
Veterans Affairs (DSS). The findings and conclusions in this report are
those of the authors and do not necessarily represent the official
position of the Centers for Disease Control and Prevention.
NR 29
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U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUN 10
PY 2011
VL 409
IS 3
BP 526
EP 531
DI 10.1016/j.bbrc.2011.05.038
PG 6
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 783CQ
UT WOS:000292059500029
PM 21600877
ER
PT J
AU Waiboci, LW
Lebo, E
Williamson, JM
Mwiti, W
Kikwai, GK
Njuguna, H
Olack, B
Breiman, RF
Njenga, MK
Katz, MA
AF Waiboci, Lilian W.
Lebo, Emmaculate
Williamson, John M.
Mwiti, William
Kikwai, Gilbert K.
Njuguna, Henry
Olack, Beatrice
Breiman, Robert F.
Njenga, M. Kariuki
Katz, Mark A.
TI Viral Shedding in Patients Infected with Pandemic Influenza A (H1N1)
Virus in Kenya, 2009
SO PLOS ONE
LA English
DT Article
ID TRANSMISSION; HUMANS; LOAD
AB Background: Understanding shedding patterns of 2009 pandemic influenza A (H1N1) (pH1N1) can inform recommendations about infection control measures. We evaluated the duration of pH1N1 virus shedding in patients in Nairobi, Kenya.
Methods: Nasopharyngeal (NP) and oropharyngeal (OP) specimens were collected from consenting laboratory-confirmed pH1N1 cases every 2 days during October 14-November 25, 2009, and tested at the Centers for Diseases Control and Prevention-Kenya by real time reverse transcriptase polymerase chain reaction (rRT-PCR). A subset of rRT-PCR-positive samples was cultured.
Results: Of 285 NP/OP specimens from patients with acute respiratory illness, 140 (49%) tested positive for pH1N1 by rRT-PCR; 106 (76%) patients consented and were enrolled. The median age was 6 years (Range: 4 months-41 years); only two patients, both asthmatic, received oseltamivir. The median duration of pH1N1 detection after illness onset was 8 days (95% CI: 7-10 days) for rRT-PCR and 3 days (Range: 0-13 days) for viral isolation. Viable pH1N1 virus was isolated from 132/162 (81%) of rRT-PCR-positive specimens, which included 118/125 (94%) rRT-PCR-positive specimens collected on day 0-7 after symptoms onset. Viral RNA was detectable in 18 (17%) and virus isolated in 7/18 (39%) of specimens collected from patients after all their symptoms had resolved.
Conclusions: In this cohort, pH1N1 was detected by rRT-PCR for a median of 8 days. There was a strong correlation between rRT-PCR results and virus isolation in the first week of illness. In some patients, pH1N1 virus was detectable after all their symptoms had resolved.
C1 [Waiboci, Lilian W.; Mwiti, William; Kikwai, Gilbert K.; Njuguna, Henry; Olack, Beatrice] US Ctr Dis Control & Prevent Kenya, Kenya Med Res Inst, Nairobi, Kenya.
[Katz, Mark A.] Natl Ctr Immunizat & Resp Dis NCIRD, Influenza Div, Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Waiboci, LW (reprint author), US Ctr Dis Control & Prevent Kenya, Kenya Med Res Inst, Nairobi, Kenya.
EM lwaiboci@ke.cdc.gov
FU US Centers for Disease Control and Prevention
FX The research was funded by the US Centers for Disease Control and
Prevention. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 26
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U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 10
PY 2011
VL 6
IS 6
AR e20320
DI 10.1371/journal.pone.0020320
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 777JU
UT WOS:000291612600008
PM 21695203
ER
PT J
AU Dawood, FS
Fry, AM
Muangchana, C
Sanasuttipun, W
Baggett, HC
Chunsuttiwat, S
Maloney, SA
Simmerman, JM
AF Dawood, Fatimah S.
Fry, Alicia M.
Muangchana, Charung
Sanasuttipun, Wiwan
Baggett, Henry C.
Chunsuttiwat, Supamit
Maloney, Susan A.
Simmerman, James Mark
TI A method for estimating vaccine-preventable pediatric influenza
pneumonia hospitalizations in developing countries: Thailand as a case
study
SO VACCINE
LA English
DT Article
DE Influenza; Vaccine; Child; Infant
ID LABORATORY-CONFIRMED INFLUENZA; YOUNG-CHILDREN; UNITED-STATES;
IMMUNIZATION; INFANTS; EFFICACY; AGE; SURVEILLANCE; INFECTION; COVERAGE
AB The burden of influenza in children is increasingly appreciated; some middle-income countries are considering support for influenza vaccine programs. To support decision-making, methods to estimate the potential impact of proposed programs are needed. Using Thailand as a case-study, we present a model that uses surveillance data, published vaccine effectiveness estimates, and vaccination coverage assumptions to estimate the impact of influenza vaccination on pediatric influenza pneumonia hospitalizations. Approximately 56,000 influenza pneumonia hospitalizations occur annually among children aged <18 years in Thailand; 23,700(41%) may be vaccine-preventable. Vaccination of 85% of Thai children aged 7 months-4 years might prevent 30% of all pediatric influenza pneumonia hospitalizations in Thailand. (C) 2011 Published by Elsevier Ltd.
C1 [Dawood, Fatimah S.] Ctr Dis Control & Prevent, Influenza Div, Epidem Intelligence Serv, Off Work Force & Career Dev, Atlanta, GA 30333 USA.
[Dawood, Fatimah S.; Fry, Alicia M.] US Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA.
[Sanasuttipun, Wiwan; Baggett, Henry C.; Maloney, Susan A.; Simmerman, James Mark] US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Int Emerging Infect Program, Nonthaburi, Thailand.
RP Dawood, FS (reprint author), Ctr Dis Control & Prevent, Influenza Div, Epidem Intelligence Serv, Off Work Force & Career Dev, 1600 Clifton Rd,MS A-32, Atlanta, GA 30333 USA.
EM fdawood@cdc.gov
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U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD JUN 10
PY 2011
VL 29
IS 26
BP 4416
EP 4421
DI 10.1016/j.vaccine.2011.03.099
PG 6
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 787CG
UT WOS:000292353600018
PM 21496470
ER
PT J
AU Maikai, BV
Umoh, JU
Kwaga, JKP
Lawal, IA
Maikai, VA
Cama, V
Xiao, LH
AF Maikai, Beatty V.
Umoh, Jalarth U.
Kwaga, Jacob K. P.
Lawal, Idris A.
Maikai, Victor A.
Cama, Vitaliano
Xiao, Lihua
TI Molecular characterization of Cryptosporidium spp. in native breeds of
cattle in Kaduna State, Nigeria
SO VETERINARY PARASITOLOGY
LA English
DT Article
DE Cryptosporidium; Molecular epidemiology; Cattle; Nigeria; Zoonosis
ID DEER-LIKE GENOTYPE; COW-CALF OPERATIONS; DAIRY-CATTLE; ZOONOTIC
TRANSMISSION; GIARDIA-DUODENALIS; UNITED-STATES; PREVALENCE; CALVES;
BOVIS; BEEF
AB Despite numerous molecular epidemiologic studies of cryptosporidiosis in dairy cattle in industrialized countries, there are very few studies on the diversity and public health significance of Cryptosporidium species in native cattle in developing countries. In this study, a polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis of the small-subunit (SSU) rRNA gene was used to detect and identify Ctyptosporidium spp. in 194 fecal specimens from 2 to 365 days old calves in 20 White Fulani and Sokoto Gudali herds in Nigeria. Thirty one (16.0%) of the specimens were positive for Cryptosporidium. Restriction digestion of the PCR products showed the presence of Cryptosporidium bovis (7.2%), Cryptosporidium ryanae (4.1%), Cryptosporidium andersoni (2.5%), and concurrent occurrence of C. bovis and C ryanae (1.5%), and C. bovis and C. andersoni (0.5%). There were no significant differences (p > 0.05) in Ctyptosporidium infection rates by sex, herd location, management system, breed of calves, or fecal consistency. However, calves 180 days or younger had a higher infection rate of Cryptosporidium than older calves (p = 0.034). Likewise, younger calves also had higher occurrence of C. bovis and C. ryanae (p = 0.022). The absence of zoonotic Cryptosporidium parvum in the calves studied suggests that native breeds of cattle may not be important in the transmission of human cryptosporidiosis in Kaduna State, Nigeria. Published by Elsevier B.V.
C1 [Maikai, Beatty V.; Xiao, Lihua] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
[Maikai, Beatty V.; Umoh, Jalarth U.; Kwaga, Jacob K. P.] Ahmadu Bello Univ, Fac Vet Med, Dept Vet Publ Hlth & Prevent Med, Zaria, Nigeria.
[Lawal, Idris A.] Ahmadu Bello Univ, Fac Vet Med, Dept Vet Parasitol & Entomol, Zaria, Nigeria.
[Maikai, Victor A.] Ahmadu Bello Univ, Coll Agr & Anim Sci, Kaduna, Nigeria.
[Cama, Vitaliano] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA.
RP Xiao, LH (reprint author), Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
EM lxiao@cdc.gov
RI Xiao, Lihua/B-1704-2013
OI Xiao, Lihua/0000-0001-8532-2727
FU Centers for Disease Control and Prevention, Atlanta, Georgia, USA
FX This work was supported in part by Centers for Disease Control and
Prevention, Atlanta, Georgia, USA. We thank Theresa Dearen for technical
assistance.
NR 34
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U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-4017
J9 VET PARASITOL
JI Vet. Parasitol.
PD JUN 10
PY 2011
VL 178
IS 3-4
BP 241
EP 245
DI 10.1016/j.vetpar.2010.12.048
PG 5
WC Parasitology; Veterinary Sciences
SC Parasitology; Veterinary Sciences
GA 781AB
UT WOS:000291901900006
PM 21277091
ER
PT J
AU Khan, SM
Debnath, C
Pramanik, AK
Xiao, LH
Nozaki, T
Ganguly, S
AF Khan, Shahbaz Manzoor
Debnath, Chanchal
Pramanik, Amiya Kumar
Xiao, Lihua
Nozaki, Tomoyoshi
Ganguly, Sandipan
TI Molecular evidence for zoonotic transmission of Giardia duodenalis among
dairy farm workers in West Bengal, India
SO VETERINARY PARASITOLOGY
LA English
DT Article
DE Giardia duodenalis; Cattle; Dairy farm workers; Zoonoses; India;
Genotyping
ID CRYPTOSPORIDIUM; CALVES; GENOTYPES; PREVALENCE; CATTLE; IDENTIFICATION;
INFECTIONS; DIARRHEA; ANIMALS; GENE
AB No study in the past has examined the genetic diversity and zoonotic potential of Giardia duodenalis in dairy cattle in India. To assess the importance of these animals as a source of human G. duodenalis infections and determine the epidemiology of bovine giardiasis in India, fecal samples from 180 calves, heifers and adults and 51 dairy farm workers on two dairy farms in West Bengal, India were genotyped by PCR-RFLP analysis of the p-giardin gene of G. duodenalis followed by DNA sequencing of the nested PCR products. The overall prevalence of G. duodenalis in cattle was 12.2% (22/180), the infection being more prevalent in younger calves than in adult cattle. Zoonotic G. duodenalis Assemblage A1 was identified in both calves and workers although the most prevalent genotype detected in cattle was a novel Assemblage E subgenotype. These findings clearly suggest that there is a potential risk of zoonotic transmission of G. duodenalis infections between cattle and humans on dairy farms in India. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Khan, Shahbaz Manzoor; Ganguly, Sandipan] Natl Inst Cholera & Enter Dis, Div Parasitol, Scheme XM, Kolkata 700010, W Bengal, India.
[Khan, Shahbaz Manzoor; Debnath, Chanchal; Pramanik, Amiya Kumar] W Bengal Univ Anim & Fishery Sci, Kolkata 700037, W Bengal, India.
[Xiao, Lihua] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Nozaki, Tomoyoshi] Natl Inst Infect Dis, Dept Parasitol, Tokyo, Japan.
RP Ganguly, S (reprint author), Natl Inst Cholera & Enter Dis, Div Parasitol, Scheme XM, P-33,CIT Rd, Kolkata 700010, W Bengal, India.
EM sandipanganguly@hotmail.com
RI khan, raja/B-5726-2012; Xiao, Lihua/B-1704-2013
OI Xiao, Lihua/0000-0001-8532-2727
FU Okayama University Program of Founding Research Centre for Emerging and
Re-emerging Infectious Disease, Ministry of Education, Culture, Sports,
Science and Technology of Japan; Japan Health Sciences Foundation; US
Embassy in India and Emerging and Re-emerging Infectious Disease and
Disease Surveillance (ERIDDS), USA; Centers for Disease Control and
Prevention, Atlanta, USA
FX This study was supported partially by grants from (i) Okayama University
Program of Founding Research Centre for Emerging and Re-emerging
Infectious Disease, Ministry of Education, Culture, Sports, Science and
Technology of Japan, (ii) The Japan Health Sciences Foundation and (iii)
US Embassy in India and Emerging and Re-emerging Infectious Disease and
Disease Surveillance (ERIDDS), USA and Centers for Disease Control and
Prevention, Atlanta, USA. The authors acknowledge Prof. Y. Takeda and
Dr. G.B. Nair for their constructive suggestions and critical review and
Mr. Avik Kumar Mukherjee and Mr. Arjun Ghosh for their technical
discussion during this study; and Debarati Ganguly of Calcutta
University for her careful proof reading and correction of English in
the manuscript.
NR 26
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U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-4017
EI 1873-2550
J9 VET PARASITOL
JI Vet. Parasitol.
PD JUN 10
PY 2011
VL 178
IS 3-4
BP 342
EP 345
DI 10.1016/j.vetpar.2011.01.029
PG 4
WC Parasitology; Veterinary Sciences
SC Parasitology; Veterinary Sciences
GA 781AB
UT WOS:000291901900020
PM 21324592
ER
PT J
AU Powell, RD
Whitworth, WC
Bernardo, J
Moonan, PK
Mazurek, GH
AF Powell, Richard D., III
Whitworth, William C.
Bernardo, John
Moonan, Patrick K.
Mazurek, Gerald H.
TI Unusual Interferon Gamma Measurements with QuantiFERON-TB Gold and
QuantiFERON-TB Gold In-Tube Tests
SO PLOS ONE
LA English
DT Article
ID MYCOBACTERIUM-TUBERCULOSIS INFECTION; RELEASE ASSAYS; UNITED-STATES;
IFN-GAMMA; SKIN-TEST; DIAGNOSIS; ANTIGENS; DISEASE
AB Introduction: Interferon gamma (IFN-gamma) release assays, such as QuantiFERON (R)-TB Gold test (QFT-G) and QuantiFERON (R)-TB Gold In-Tube test (QFT-GIT) are designed to detect M. tuberculosis (Mtb) infection. Recognition of unusual IFN-gamma measurements may help indicate inaccurate results.
Methods: We examined QFT-G and QFT-GIT results from subjects who had two or more tests completed. We classified unusual IFN-gamma measurements as: 1) High Nil Concentration (HNC) when IFN-gamma concentration in plasma from unstimulated blood exceeded 0.7 IU/mL; 2) Low Mitogen Response (LMR) when Mitogen Response was <0.5 IU/mL; 3) Very Low Mitogen Response (VLMR) when Mitogen Response was <=-0.5 IU/mL; and 4) Very Low Antigen Response (VLAR) when the response to a Mtb antigen was <=-0.35 IU/mL and <=-0.5 times the IFN-gamma concentration in plasma from unstimulated blood.
Results: Among 5,309 results from 1,728 subjects, HNC occurred in 234 (4.4%) tests for 162 subjects, LMR in 108 (2.0%) tests for 85 subjects, VLMR in 22 (0.4%) tests for 21 subjects, and VLAR in 41 (0.8%) tests for 39 subjects. QFT-GIT had fewer HNC, VLMR, and VLAR (p = 0.042, 0.004, and 0.067 respectively); QFT-G had fewer LMR (p = 0.005). Twenty-four (51.6%) of 47 subjects with positive results and HNC were negative or indeterminate by all other tests. Thirteen (61.9%) of 21 subjects with positive results and LMR were negative or indeterminate by all other tests.
Conclusion: Unusual IFN-gamma measurements including HNC, LMR, VLMR, and VLAR were encountered in small numbers, and in most instances were not seen on simultaneously or subsequently performed tests. To avoid erroneous diagnosis of Mtb infection, IGRAs with unusual IFN-gamma measurements should be repeated with another blood sample and interpreted with caution if they recur.
C1 [Powell, Richard D., III; Whitworth, William C.; Moonan, Patrick K.; Mazurek, Gerald H.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA.
[Bernardo, John] Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA.
RP Powell, RD (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA.
EM gym6@cdc.gov
RI Moonan, Patrick/F-4307-2014;
OI Moonan, Patrick/0000-0002-3550-2065; Bernardo, John/0000-0002-3922-0559
NR 19
TC 12
Z9 12
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 8
PY 2011
VL 6
IS 6
AR e20061
DI 10.1371/journal.pone.0020061
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 777JJ
UT WOS:000291611500007
PM 21687702
ER
PT J
AU Rowland, JH
Mariotto, A
Alfano, CM
Pollack, LA
Weir, HK
White, A
AF Rowland, J. H.
Mariotto, A.
Alfano, C. M.
Pollack, L. A.
Weir, H. K.
White, A.
TI Cancer Survivors-United States, 2007 (Reprinted from MMWR, vol 60, pg
269, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
ID PREVALENCE
C1 [Rowland, J. H.; Mariotto, A.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
[White, A.] CDC, EIS, Atlanta, GA 30333 USA.
RP Rowland, JH (reprint author), NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
NR 11
TC 0
Z9 0
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 8
PY 2011
VL 305
IS 22
BP 2281
EP 2282
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 773YV
UT WOS:000291349100006
ER
PT J
AU McKenna, M
Hawk, E
Mullen, J
Hertz, M
AF McKenna, M.
Hawk, E.
Mullen, J.
Hertz, M.
TI Bullying Among Middle School and High School Students-Massachusetts,
2009 (Reprinted from MMWR, vol 60, pg 465-471, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
ID CHILDHOOD; METAANALYSIS; ASSOCIATION; YOUTH
C1 [Hertz, M.] CDC, Div Adolescent & Sch Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
[McKenna, M.; Hawk, E.; Mullen, J.] Massachusetts Dept Publ Hlth, Boston, MA 02111 USA.
RP Hertz, M (reprint author), CDC, Div Adolescent & Sch Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
EM mhertz@cdc.gov
NR 11
TC 1
Z9 1
U1 0
U2 3
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 8
PY 2011
VL 305
IS 22
BP 2283
EP 2286
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 773YV
UT WOS:000291349100007
ER
PT J
AU Wu, XF
Franka, R
Henderson, H
Rupprecht, CE
AF Wu, Xianfu
Franka, Richard
Henderson, Heather
Rupprecht, Charles E.
TI Live attenuated rabies virus co-infected with street rabies virus
protects animals against rabies
SO VACCINE
LA English
DT Article
DE Rabies; Pre-exposure prophylaxis; Rabies vaccination regimen; Attenuated
rabies virus ERAg3m; Co-infection
ID CENTRAL-NERVOUS-SYSTEM; POSTEXPOSURE PROPHYLAXIS; IMMUNE-RESPONSES;
VACCINE; CHILDREN; SAFETY; IMMUNOGENICITY; IMMUNIZATION; PREGNANCY;
EXPOSURE
AB While current rabies post-exposure prophylaxis (PEP) is highly effective, it is costly and the vaccination regimen is complicated, requiring both inactivated vaccines and immunoglobulins. A one-dose rabies vaccine for human PEP remains a long-term goal. Here, we describe development of a highly attenuated rabies virus ERAg3m, with a mutation in the glycoprotein (G) gene and a switch of the G gene with the matrix protein gene in the viral genome. After a one-dose intramuscular vaccination, the ERAg3m virus protected 100% of mice and hamsters from lethal challenge. In co-infections, using a lethal dose of street rabies virus mixed with ERAg3m, 100% of hamsters and 90% of mice survived and were protected against subsequent infection. A mock co-infection, using inactivated commercial human rabies vaccine and a lethal dose of street rabies virus, protected 100% and 40% of hamsters and mice, respectively. In co-infections, when vaccine was administrated in the left leg and challenge virus in the right leg, the ERAg3m virus protected 40% of mice, while the inactivated vaccine showed no protection. Therefore, live attenuated rabies virus when given pre-exposure or co-infected with street rabies virus, is capable of preventing rabies in two different animal models. Overall, this highly attenuated live rabies virus offered better protection than the inactivated vaccine. Published by Elsevier Ltd.
C1 [Wu, Xianfu; Franka, Richard; Henderson, Heather; Rupprecht, Charles E.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Wu, XF (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS G33, Atlanta, GA 30333 USA.
EM XAW6@cdc.gov
NR 45
TC 10
Z9 12
U1 0
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD JUN 6
PY 2011
VL 29
IS 25
BP 4195
EP 4201
DI 10.1016/j.vaccine.2011.03.104
PG 7
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 779KY
UT WOS:000291777700006
PM 21514343
ER
PT J
AU Bayoh, MN
Akhwale, W
Ombok, M
Sang, D
Engoki, SC
Koros, D
Walker, ED
Williams, HA
Burke, H
Armstrong, GL
Cetron, MS
Weinberg, M
Breiman, R
Hamel, MJ
AF Bayoh, M. Nabie
Akhwale, Willis
Ombok, Maurice
Sang, David
Engoki, Sammy C.
Koros, Dan
Walker, Edward D.
Williams, Holly A.
Burke, Heather
Armstrong, Gregory L.
Cetron, Martin S.
Weinberg, Michelle
Breiman, Robert
Hamel, Mary J.
TI Malaria in Kakuma refugee camp, Turkana, Kenya: facilitation of
Anopheles arabiensis vector populations by installed water distribution
and catchment systems
SO MALARIA JOURNAL
LA English
DT Article
ID GAMBIAE; TRANSMISSION; ETHIOPIA; CHILDREN; COMPLEX; DAMS; AREA
AB Background: Malaria is a major health concern for displaced persons occupying refugee camps in sub-Saharan Africa, yet there is little information on the incidence of infection and nature of transmission in these settings. Kakuma Refugee Camp, located in a dry area of north-western Kenya, has hosted ca. 60,000 to 90,000 refugees since 1992, primarily from Sudan and Somalia. The purpose of this study was to investigate malaria prevalence and attack rate and sources of Anopheles vectors in Kakuma refugee camp, in 2005-2006, after a malaria epidemic was observed by staff at camp clinics.
Methods: Malaria prevalence and attack rate was estimated from cases of fever presenting to camp clinics and the hospital in August 2005, using rapid diagnostic tests and microscopy of blood smears. Larval habitats of vectors were sampled and mapped. Houses were sampled for adult vectors using the pyrethrum knockdown spray method, and mapped. Vectors were identified to species level and their infection with Plasmodium falciparum determined.
Results: Prevalence of febrile illness with P. falciparum was highest among the 5 to 17 year olds (62.4%) while malaria attack rate was highest among the two to 4 year olds (5.2/1,000/day). Infected individuals were spatially concentrated in three of the 11 residential zones of the camp. The indoor densities of Anopheles arabiensis, the sole malaria vector, were similar during the wet and dry seasons, but were distributed in an aggregated fashion and predominantly in the same zones where malaria attack rates were high. Larval habitats and larval populations were also concentrated in these zones. Larval habitats were man-made pits of water associated with tap-stands installed as the water delivery system to residents with year round availability in the camp. Three percent of A. arabiensis adult females were infected with P. falciparum sporozoites in the rainy season.
Conclusions: Malaria in Kakuma refugee camp was due mainly to infection with P. falciparum and showed a hyperendemic age-prevalence profile, in an area with otherwise low risk of malaria given prevailing climate. Transmission was sustained by A. arabiensis, whose populations were facilitated by installation of man-made water distribution and catchment systems.
C1 [Bayoh, M. Nabie; Ombok, Maurice; Burke, Heather; Hamel, Mary J.] Ctr Dis Control & Prevent, Ctr Global Hlth Res, Kenya Med Res Inst, Kisumu, Kenya.
[Akhwale, Willis; Sang, David] Minist Hlth, Div Malaria Control, Nairobi, Kenya.
[Sang, David] Kenya Methodist Univ, Meru, Kenya.
[Engoki, Sammy C.; Koros, Dan] Int Rescue Comm, Kakuma Refugee Camp, Kenya.
[Walker, Edward D.] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA.
[Williams, Holly A.; Burke, Heather; Armstrong, Gregory L.; Cetron, Martin S.; Weinberg, Michelle] Ctr Dis Control & Prevent, Int Emergency & Refugee Hlth Branch, Atlanta, GA 30333 USA.
[Breiman, Robert] Int Emerging Infect Programme, Ctr Dis Control & Prevent, Nairobi, Kenya.
[Hamel, Mary J.] Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA 30301 USA.
RP Bayoh, MN (reprint author), Ctr Dis Control & Prevent, Ctr Global Hlth Res, Kenya Med Res Inst, POB 1578, Kisumu, Kenya.
EM nbayoh@ke.cdc.gov
FU U.S. Centres for Disease Control and Prevention; International Rescue
Committee; NIAID [AI-50703]
FX The authors are grateful for the field and laboratory assistance
provided by Samson Otieno, Ben Oloo, Martin Owaga and Joseph Nduati and
statistical review by John Williamson; all at the Centre for Global
Health Research, Kenya Medical Research Institute/Centres for Disease
Control and Prevention, Kisumu, Kenya. This investigation was supported
in part by the International Emerging Infections Program, U.S. Centres
for Disease Control and Prevention; NIAID grant AI-50703 to EDW, and the
International Rescue Committee.
NR 23
TC 7
Z9 7
U1 1
U2 13
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD JUN 4
PY 2011
VL 10
AR 149
DI 10.1186/1475-2875-10-149
PG 11
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 789LM
UT WOS:000292517000001
PM 21639926
ER
PT J
AU Han, T
Sui, JH
Bennett, AS
Liddington, RC
Donis, RO
Zhu, Q
Marasco, WA
AF Han, Thomas
Sui, Jianhua
Bennett, Andrew S.
Liddington, Robert C.
Donis, Ruben O.
Zhu, Quan
Marasco, Wayne A.
TI Fine epitope mapping of monoclonal antibodies against hemagglutinin of a
highly pathogenic H5N1 influenza virus using yeast surface display
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Yeast surface display; Fine epitope mapping; Influenza; H5N1
ID VACCINES
AB Highly pathogenic H5N1 avian influenza viruses pose a debilitating pandemic threat. Thus, understanding mechanisms of antibody-mediated viral inhibition and neutralization escape is critical. Here, a robust yeast display system for fine epitope mapping of viral surface hemagglutinin (HA)-specific antibodies is demonstrated. The full-length H5 subtype HA (HA0) was expressed on the yeast surface in a correctly folded conformation, determined by binding of a panel of extensively characterized neutralizing human monoclonal antibodies (mAbs). These mAbs target conformationally-dependent epitopes of influenza A HA, which are highly conserved across H5 clades and group 1 serotypes. By separately displaying HA1 and HA2 subunits on yeast, domain mapping of two anti-H5 mAbs, NR2728 and H5-2A, localized their epitopes to HA1. These anti-H5 mAb epitopes were further fine mapped by using a library of yeast-displayed HA1 mutants and selecting for loss of binding without prior knowledge of potential contact residues. By overlaying key mutant residues that impacted binding onto a crystal structure of HA, the NR2728 mAb was found to interact with a fully surface-exposed contiguous patch of residues at the receptor binding site (RBS), giving insight into the mechanism underlying its potent inhibition of virus binding. The non-neutralizing H5-2A mAb was similarly mapped to a highly conserved H5 strain-specific but poorly accessible location on a loop at the trimer HA interface. These data further augment our tool-chest for studying HA antigenicity, epitope diversity and accessibility in response to natural and experimental influenza infection and vaccines. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Han, Thomas; Sui, Jianhua; Bennett, Andrew S.; Zhu, Quan; Marasco, Wayne A.] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02215 USA.
[Liddington, Robert C.] Burnham Inst Med Res, Infect & Inflammatory Dis Ctr, La Jolla, CA 92037 USA.
[Donis, Ruben O.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Marasco, WA (reprint author), Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, 450 Brookline Ave, Boston, MA 02215 USA.
EM wayne_marasco@dfci.harvard.edu
OI SUI, JIANHUA/0000-0002-1272-9662
FU National Institutes of Health [U01-AI074518-01, 1K01AI073861]
FX This work was supported by Grants from the National Institutes of
Health: U01-AI074518-01 to W.A.M. and 1K01AI073861 to T.H. The findings
and conclusions in this report are those of the authors and do not
necessarily reflect the views of the funding agency.
NR 12
TC 21
Z9 21
U1 0
U2 14
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUN 3
PY 2011
VL 409
IS 2
BP 253
EP 259
DI 10.1016/j.bbrc.2011.04.139
PG 7
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 779LM
UT WOS:000291779100018
PM 21569761
ER
PT J
AU Dawood, FS
Ambrose, JF
Russell, BP
Hawksworth, AW
Winchell, JM
Glass, N
Thurman, K
Soltis, MA
McDonough, E
Warner, AK
Weston, E
Clemmons, NS
Rosen, J
Mitchell, SL
Faix, DJ
Blair, PJ
Moore, MR
Lowery, J
AF Dawood, Fatimah S.
Ambrose, John F.
Russell, Bruce P.
Hawksworth, Anthony W.
Winchell, Jonas M.
Glass, Nina
Thurman, Kathleen
Soltis, Michele A.
McDonough, Erin
Warner, Agnes K.
Weston, Emily
Clemmons, Nakia S.
Rosen, Jennifer
Mitchell, Stephanie L.
Faix, Dennis J.
Blair, Patrick J.
Moore, Matthew R.
Lowery, John
TI Outbreak of Pneumonia in the Setting of Fatal Pneumococcal Meningitis
among US Army Trainees: Potential Role of Chlamydia pneumoniae Infection
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Pneumonia; pneumococcal; Chlamydophila; pneumoniae; Military Personnel
ID REAL-TIME PCR; STREPTOCOCCUS-PNEUMONIAE; MYCOPLASMA-PNEUMONIAE; MILITARY
PERSONNEL; EPIDEMIC; FINLAND; COMMUNITY
AB Background: Compared to the civilian population, military trainees are often at increased risk for respiratory infections. We investigated an outbreak of radiologically-confirmed pneumonia that was recognized after 2 fatal cases of serotype 7F pneumococcal meningitis were reported in a 303-person military trainee company (Alpha Company).
Methods: We reviewed surveillance data on pneumonia and febrile respiratory illness at the training facility; conducted chart reviews for cases of radiologically-confirmed pneumonia; and administered surveys and collected nasopharyngeal swabs from trainees in the outbreak battalion (Alpha and Hotel Companies), associated training staff, and trainees newly joining the battalion.
Results: Among Alpha and Hotel Company trainees, the average weekly attack rates of radiologically-confirmed pneumonia were 1.4% and 1.2% (most other companies at FLW: 0-0.4%). The pneumococcal carriage rate among all Alpha Company trainees was 15% with a predominance of serotypes 7F and 3. Chlamydia pneumoniae was identified from 31% of specimens collected from Alpha Company trainees with respiratory symptoms.
Conclusion: Although the etiology of the outbreak remains unclear, the identification of both S. pneumoniae and C. pneumoniae among trainees suggests that both pathogens may have contributed either independently or as cofactors to the observed increased incidence of pneumonia in the outbreak battalion and should be considered as possible etiologies in outbreaks of pneumonia in the military population.
C1 [Dawood, Fatimah S.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Influenza Epidemiol & Prevent Branch,Influenza Di, Atlanta, GA 30333 USA.
[Winchell, Jonas M.; Glass, Nina; Thurman, Kathleen; Warner, Agnes K.; Weston, Emily; Rosen, Jennifer; Mitchell, Stephanie L.; Moore, Matthew R.] Ctr Dis Control & Prevent, Resp Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Ambrose, John F.; Soltis, Michele A.; Clemmons, Nakia S.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA.
[Russell, Bruce P.] Gen Leonard Wood Army Community Hosp, Div Prevent Med, Ft Leonard Wood, MO 65473 USA.
[Hawksworth, Anthony W.; McDonough, Erin; Faix, Dennis J.; Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92106 USA.
RP Dawood, FS (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Influenza Epidemiol & Prevent Branch,Influenza Di, 1600 Clifton Rd NE, Atlanta, GA 30333 USA.
EM fdawood@cdc.gov; zdn4@cdc.gov
RI Valle, Ruben/A-7512-2013;
OI Glass, Nina/0000-0002-6821-4289
NR 19
TC 11
Z9 11
U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD JUN 2
PY 2011
VL 11
AR 157
DI 10.1186/1471-2334-11-157
PG 9
WC Infectious Diseases
SC Infectious Diseases
GA 783KN
UT WOS:000292081300001
PM 21635754
ER
PT J
AU Wilder-Kofie, TD
Luquez, C
Adler, M
Dykes, JK
Coleman, JD
Maslanka, SE
AF Wilder-Kofie, Temeri D.
Luquez, Carolina
Adler, Michael
Dykes, Janet K.
Coleman, JoAnn D.
Maslanka, Susan E.
TI An Alternative In Vivo Method to Refine the Mouse Bioassay for Botulinum
Toxin Detection
SO COMPARATIVE MEDICINE
LA English
DT Article
ID NEUROTOXIN; MUSCLE
AB Botulism is a rare, life-threatening paralytic disease of both humans and animals that is caused by botulinum neurotoxins (BoNT). Botulism is confirmed in the laboratory by the detection of BoNT in clinical specimens, contaminated foods, and cultures. Despite efforts to develop an in vitro method for botulinum toxin detection, the mouse bioassay remains the standard test for laboratory confirmation of this disease. In this study, we evaluated the use of a nonlethal mouse toe-spread reflex model to detect BoNT spiked into buffer, serum, and milk samples. Samples spiked with toxin serotype A and nontoxin control samples were injected into the left and right extensor digitorum longus muscles, respectively. Digital photographs at 0, 8, and 24 h were used to obtain objective measurements through effective paralysis scores, which were determined by comparing the width-to-length ratio between right and left feet. Both objective measurements and clinical observation could accurately identify over 80% of animals injected with 1 LD50 (4.3 pg) BoNT type A within 24 h. Half of animals injected with 0.5 LD50 BoNT type A and none injected with 0.25 LD50 demonstrated localized paralysis. Preincubating the toxin with antitoxin prevented the development of positive effective paralysis scores, demonstrating that (1) the effect was specific for BoNT and (2) identification of toxin serotype could be achieved by using this method. These results suggest that the mouse toe-spread reflex model may be a more humane alternative to the current mouse bioassay for laboratory investigations of botulism.
C1 [Luquez, Carolina; Dykes, Janet K.; Maslanka, Susan E.] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA.
[Wilder-Kofie, Temeri D.; Coleman, JoAnn D.] Ctr Dis Control & Prevent, Div Sci Resources, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA.
[Adler, Michael] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Maslanka, SE (reprint author), Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA.
EM SMaslanka@cdc.gov
FU Office for Public Health (Centers for Disease Control and Prevention,
Atlanta, GA); CDC Laboratory Animal Medicine Residency, Division of
Scientific Resources, National Center for Emerging Zoonotic and
Infectious Disease
FX This publication was supported by funds made available from the Office
for Public Health Preparedness and Response (Centers for Disease Control
and Prevention, Atlanta, GA). Additional funds were made available from
the CDC Laboratory Animal Medicine Residency Program, Division of
Scientific Resources, National Center for Emerging Zoonotic and
Infectious Disease. The findings and conclusions in this report are
those of the authors and do not necessarily represent the views of the
Centers for Disease Control and Prevention.
NR 18
TC 13
Z9 13
U1 1
U2 12
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1532-0820
J9 COMPARATIVE MED
JI Comparative Med.
PD JUN
PY 2011
VL 61
IS 3
BP 235
EP 242
PG 8
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 915QQ
UT WOS:000302042900007
PM 21819693
ER
PT J
AU Singleton, RJ
Holman, RC
Wenger, J
Christensen, KY
Bulkow, LR
Zulz, T
Steiner, CA
Cheek, JE
AF Singleton, Rosalyn J.
Holman, Robert C.
Wenger, Jay
Christensen, Krista Yorita
Bulkow, Lisa R.
Zulz, Tammy
Steiner, Claudia A.
Cheek, James E.
TI TRENDS IN HOSPITALIZATION FOR EMPYEMA IN ALASKA NATIVE CHILDREN YOUNGER
THAN 10 YEARS OF AGE
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
DE empyema; pleural effusions; Alaska Native; United States;
hospitalizations; children
ID PNEUMOCOCCAL CONJUGATE VACCINE; NONVACCINE SEROTYPES; CHILDHOOD EMPYEMA;
US CHILDREN
AB We analyzed hospitalizations for empyema among Alaska Native (AN) children and the general population of US children <10 years of age during the years 1998 to 2007. We also analyzed invasive pneumococcal disease in AN children. Between 1998 and 2000, the average annual hospitalization rate for empyema was higher for AN children (51.8 per 100,000/yr) than that for US children (24.2 [95% confidence interval: 20.4, 27.9right perpendicular per 100,000/yr), and had increased in 2004-2007 in both populations (59.6 and 36.0 [95% confidence interval: 30.1, 41.8], respectively). Pneumococcal empyema increased in AN children despite a decrease in invasive pneumococcal disease pneumonia.
C1 [Singleton, Rosalyn J.] CDC, AIP, NCEZID, US Dept HHS, Anchorage, AK 99508 USA.
[Holman, Robert C.; Christensen, Krista Yorita] CDC, Div High Consequence Pathogens & Pathol, NCEZID, US Dept HHS, Atlanta, GA 30333 USA.
[Steiner, Claudia A.] Agcy Healthcare Res & Qual, Healthcare Cost & Utilizat Project, Rockville, MD USA.
[Cheek, James E.] Indian Hlth Serv, Div Epidemiol & Prevent, Off Publ Hlth Support, US Dept HHS, Albuquerque, NM USA.
RP Singleton, RJ (reprint author), CDC, AIP, NCEZID, US Dept HHS, 4055 Tudor Ctr Dr, Anchorage, AK 99508 USA.
NR 16
TC 7
Z9 7
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0891-3668
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD JUN
PY 2011
VL 30
IS 6
BP 528
EP 530
DI 10.1097/INF.0b013e3182075e74
PG 3
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA 770OB
UT WOS:000291095600022
PM 21164385
ER
PT J
AU Bergen, G
Shults, RA
Beck, L
AF Bergen, G.
Shults, R. A.
Beck, L.
TI SELF-REPORTED ALCOHOL-IMPAIRED DRIVING IN THE UNITED STATES, 2006 AND
2008
SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Meeting Abstract
CT 34th Annual Scientific Meeting of the Research-Society-on-Alcoholism
CY JUN 25-29, 2011
CL Atlanta, GA
SP Res Soc Alcoholism
C1 [Bergen, G.; Shults, R. A.; Beck, L.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0145-6008
J9 ALCOHOL CLIN EXP RES
JI Alcoholism (NY)
PD JUN
PY 2011
VL 35
IS 6
SU S
BP 150A
EP 150A
PG 1
WC Substance Abuse
SC Substance Abuse
GA 766RN
UT WOS:000290804301055
ER
PT J
AU Sejvar, JJ
AF Sejvar, James J.
TI Vaccines and Neurologic Disease
SO SEMINARS IN NEUROLOGY
LA English
DT Article
DE Vaccines; encephalitis; virus; adverse events
ID GUILLAIN-BARRE-SYNDROME; IMMUNIZATION PRACTICES ACIP; PREVENT
HERPES-ZOSTER; ACUTE DISSEMINATED ENCEPHALOMYELITIS; PRACTICE RESEARCH
DATABASE; SAFETY DATALINK PROJECT; EVENT-REPORTING-SYSTEM;
UNITED-STATES; MENINGOCOCCAL DISEASE; INFLUENZA VACCINATION
AB Vaccines have undoubtedly been a medical milestone, preventing immeasurable morbidity and mortality from infectious diseases worldwide. Modern vaccines have tremendously reduced the global impact of numerous infections; they have succeeded in eliminating smallpox completely. However, the nature by which vaccines confer their protection-by stimulation of the immune system-means that in rare cases, adverse often immunologically mediated events may occur following vaccination. Some of the most severe of these involve the nervous system. The author provides an overview of the mechanisms of vaccinology, and describes the various vaccines available for particular neurologic illnesses. Possible neurologic adverse events following vaccinations, and the possible mechanisms of these events, are also discussed. Finally, procedures in place to ensure vaccine safety are reviewed.
C1 Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA.
RP Sejvar, JJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, 1600 Clifton Rd,Mailstop A-39, Atlanta, GA 30333 USA.
EM zea3@cdc.gov
RI Davis, Bridget/G-3709-2011
NR 159
TC 1
Z9 1
U1 1
U2 5
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0271-8235
J9 SEMIN NEUROL
JI Semin. Neurol.
PD JUN
PY 2011
VL 31
IS 3
BP 338
EP 355
DI 10.1055/s-0031-1287655
PG 18
WC Clinical Neurology
SC Neurosciences & Neurology
GA 827DI
UT WOS:000295406900011
PM 21964850
ER
PT J
AU Wurzelbacher, S
Jin, Y
AF Wurzelbacher, Steve
Jin, Yan
TI A framework for evaluating OSH program effectiveness using leading and
trailing metrics
SO JOURNAL OF SAFETY RESEARCH
LA English
DT Article
DE Leading; Trailing; Workers compensation; Program evaluation;
Effectiveness
ID PERFORMANCE-MEASUREMENT TOOL; BACK-PAIN CLAIMS; LONG-TERM IMPACT;
OCCUPATIONAL-HEALTH; ORGANIZATIONAL POLICIES; WORKPLACE FACTORS;
WELLNESS PROGRAM; JOHNSONS HEALTH; WORK DISABILITY; SAFETY
AB Introduction: Many employers and regulators today rely primarily on a few past injury/ illness metrics as criteria for rating the effectiveness of occupational safety and health (OSH) programs. Although such trailing data are necessary to assess program success, they may not be sufficient for developing proactive safety, ergonomic, and medical management plans. Methods: The goals of this pilot study were to create leading metrics (company self-assessment ratings) and trailing metrics (past loss data) that could be used to evaluate the effectiveness of OSH program elements that range from primary to tertiary prevention. The main hypothesis was that the new metrics would be explanatory variables for three standard future workers compensation (WC) outcomes in 2003 (rates of total cases, lost time cases, and costs) and that the framework for evaluating OSH programs could be justifiably expanded. For leading metrics, surveys were developed to allow respondents to assess OSH exposures and program prevention elements (management leadership/ commitment, employee participation, hazard identification, hazard control, medical management, training, and program evaluation). After pre-testing, surveys were sent to companies covered by the same WC insurer in early 2003. A total of 33 completed surveys were used for final analysis. A series of trailing metrics were developed from 1999-2001 WC data for the surveyed companies. Data were analyzed using a method where each main 2003 WC outcome was dichotomized into high and low loss groups based on the median value of the variable. The mean and standard deviations of survey questions and 1999-2001 WC variables were compared between the dichotomized groups. Hypothesis testing was performed using F-test with a significance level 0.10. Results/Discussion: Companies that exhibited higher musculoskeletal disorder (MSD) WC case rates from 1999-2001 had higher total WC case rates in 2003. Higher levels of several self-reported OSH program elements (tracking progress in controlling workplace safety hazards, identifying ergonomic hazards, using health promotion programs) were associated with lower rates of WC lost time cases in 2003. Higher reported exposures to noise and projectiles were also associated with higher rates of WC cases and costs in 2003. Impact on Industry: This research adds to a growing body of preliminary evidence that valid leading and trailing metrics can be developed to evaluate OSH effectiveness. Both the rating of OSH efforts and the regular trending of past loss outcomes are likely useful in developing data-driven improvement plans that are reactive to past exposures and proactive in identifying system deficiencies that drive future losses. Published by Elsevier Ltd.
C1 [Wurzelbacher, Steve; Jin, Yan] NIOSH, Ctr Dis Control, Cincinnati, OH 45226 USA.
RP Wurzelbacher, S (reprint author), NIOSH, Ctr Dis Control, 4676 Columbia Pkwy,Mail Stop R-14, Cincinnati, OH 45226 USA.
EM srw3@cdc.gov
NR 48
TC 3
Z9 3
U1 4
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4375
J9 J SAFETY RES
JI J. Saf. Res.
PD JUN
PY 2011
VL 42
IS 3
BP 199
EP 207
DI 10.1016/j.jsr.2011.04.001
PG 9
WC Ergonomics; Public, Environmental & Occupational Health; Social
Sciences, Interdisciplinary; Transportation
SC Engineering; Public, Environmental & Occupational Health; Social
Sciences - Other Topics; Transportation
GA 820VT
UT WOS:000294934900007
PM 21855691
ER
PT J
AU Balluz, L
Hu, SS
Battaglia, MP
Frankel, MR
AF Balluz, L.
Hu, S. S.
Battaglia, M. P.
Frankel, M. R.
TI NONCOVERAGE BIAS IN HOUSEHOLD LANDLINE TELEPHONE SURVEYS, BRFSS 2008
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Balluz, L.; Hu, S. S.; Battaglia, M. P.; Frankel, M. R.] CDC, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S108
EP S108
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600423
ER
PT J
AU Branum, AM
Caulfield, LE
AF Branum, A. M.
Caulfield, L. E.
TI MULTILEVEL DETERMINANTS OF CHILD AND ADOLESCENT FRUIT AND VEGETABLE
INTAKE
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Branum, A. M.; Caulfield, L. E.] NCHS, CDC, Hyattsville, MD 20782 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S278
EP S278
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601375
ER
PT J
AU Gill, S
Broussard, C
Devine, O
Green, RF
Rasmussen, S
Reefhuis, J
AF Gill, S.
Broussard, C.
Devine, O.
Green, R. Fisk
Rasmussen, S.
Reefhuis, J.
TI MATERNAL AGE AND THE RISK FOR BIRTH DEFECTS OF UNKNOWN ETIOLOGY: A
POPULATION-BASED STUDY, 1997-2005
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Gill, S.; Broussard, C.; Devine, O.; Green, R. Fisk; Rasmussen, S.; Reefhuis, J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S134
EP S134
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600520
ER
PT J
AU Hinkle, S
Sharma, A
Kim, S
Park, S
Dalenius, K
Brindley, T
Grummer-Strawn, L
AF Hinkle, S.
Sharma, A.
Kim, S.
Park, S.
Dalenius, K.
Brindley, T.
Grummer-Strawn, L.
TI PREPREGNANCY OBESITY TRENDS AMONG LOW-INCOME US WOMEN
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Hinkle, S.; Sharma, A.; Kim, S.; Park, S.; Dalenius, K.; Brindley, T.; Grummer-Strawn, L.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S293
EP S293
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601434
ER
PT J
AU Honein, M
Devine, O
Sharma, A
Park, S
Rasmussen, S
Kucik, J
Sniezek, J
Boyle, C
AF Honein, M.
Devine, O.
Sharma, A.
Park, S.
Rasmussen, S.
Kucik, J.
Sniezek, J.
Boyle, C.
TI MODELING THE PUBLIC HEALTH IMPACT OF PRE-PREGNANCY OBESITY ON SELECTED
INFANT OUTCOMES
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Honein, M.; Devine, O.; Sharma, A.; Park, S.; Rasmussen, S.; Kucik, J.; Sniezek, J.; Boyle, C.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S294
EP S294
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601439
ER
PT J
AU Huang, DT
Klein, RJ
AF Huang, D. T.
Klein, R. J.
TI GENERAL HEALTH STATUS: TRACKING HEALTHY PEOPLE 2020 FOUNDATION HEALTH
MEASURES
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Huang, D. T.; Klein, R. J.] CDC, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
RI Huang, David/A-5358-2009
OI Huang, David/0000-0002-8860-7469
NR 0
TC 0
Z9 0
U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S22
EP S22
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600083
ER
PT J
AU Kumar, M
King, JB
Eheman, CR
AF Kumar, Mridhula
King, Jessica B.
Eheman, Christie R.
TI MALE BREAST CANCER-GEOGRAPHIC VARIATION IN THE UNITED STATES
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Kumar, Mridhula; King, Jessica B.; Eheman, Christie R.] Ctr Dis Control & Prevent, Canc Surveillance Branch, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S1
EP S1
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600004
ER
PT J
AU Lawson, CC
Rocheleau, CM
Whelan, EA
Hibert, EN
Grajewski, B
Spiegelman, D
Rich-Edwards, JW
AF Lawson, C. C.
Rocheleau, C. M.
Whelan, E. A.
Hibert, E. N.
Grajewski, B.
Spiegelman, D.
Rich-Edwards, J. W.
TI OCCUPATIONAL EXPOSURE TO ANESTHETIC GASES, ANTINEOPLASTIC DRUGS,
ANTIVIRAL DRUGS, STERILIZING AGENTS, AND X-RAYS AND RISK OF SPONTANEOUS
ABORTION AMONG NURSES
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Lawson, C. C.; Rocheleau, C. M.; Whelan, E. A.; Hibert, E. N.; Grajewski, B.; Spiegelman, D.; Rich-Edwards, J. W.] NIOSH, Cincinnati, OH 45213 USA.
NR 0
TC 0
Z9 0
U1 0
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S296
EP S296
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601446
ER
PT J
AU Magee, M
Bloss, E
Shin, S
Contreras, C
Huaman, HA
Ticona, JC
Bayona, J
Bonilla, C
Yagui, M
Jave, O
Cegielski, P
AF Magee, M.
Bloss, E.
Shin, S.
Contreras, C.
Huaman, H. Arbanil
Ticona, J. Calderon
Bayona, J.
Bonilla, C.
Yagui, M.
Jave, O.
Cegielski, P.
TI FACTORS ASSOCIATED WITH DRUG RESISTANT TUBERCULOSIS (DRTB) AMONG
PATIENTS WITH TUBERCULOSIS (TB) AND DIABETES MELLITUS (DM) IN PERU
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Magee, M.; Bloss, E.; Shin, S.; Contreras, C.; Huaman, H. Arbanil; Ticona, J. Calderon; Bayona, J.; Bonilla, C.; Yagui, M.; Jave, O.; Cegielski, P.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S182
EP S182
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601008
ER
PT J
AU Pratt, LA
Brody, DJ
Gu, Q
AF Pratt, L. A.
Brody, D. J.
Gu, Q.
TI COMPARISON OF MULTIPLE ESTIMATES OF DEPRESSION PREVALENCE USING THE
PATIENT HEALTH QUESTIONNAIRE-9 AND REPORTED REASON FOR USE OF
ANTIDEPRESSANTS: NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY:
2005-2008
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Pratt, L. A.; Brody, D. J.; Gu, Q.] CDC, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S65
EP S65
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600251
ER
PT J
AU Ryskulova, A
Klein, R
Hines, R
AF Ryskulova, A.
Klein, R.
Hines, R.
TI APPLYING FEDERAL PHYSICAL ACTIVITY GUIDELINES TO HEALTHY PEOPLE 2020
OBJECTIVES
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Ryskulova, A.; Klein, R.; Hines, R.] Natl Ctr Hlth Stat, CDC, Hyattsville, MD 20782 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S32
EP S32
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600126
ER
PT J
AU Saaddine, J
Chou, CF
Zhang, X
Cotch, MF
Geiss, L
Klein, BE
Klein, R
AF Saaddine, J.
Chou, C. F.
Zhang, X.
Cotch, M. F.
Geiss, L.
Klein, B. E.
Klein, R.
TI NON-DIABETIC RETINOPATHY IN THE UNITED STATES: 2005-2008.
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Saaddine, J.; Chou, C. F.; Zhang, X.; Cotch, M. F.; Geiss, L.; Klein, B. E.; Klein, R.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S171
EP S171
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600669
ER
PT J
AU Shin, M
O'Leary, L
Cragan, J
Thorpe, P
Correa, A
AF Shin, M.
O'Leary, L.
Cragan, J.
Thorpe, P.
Correa, A.
TI AGE AT DIAGNOSIS OF CHILDREN WITH BIRTH DEFECTS IN THE METROPOLITAN
ATLANTA CONGENITAL DEFECTS PROGRAM, 1998-2001
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Shin, M.; O'Leary, L.; Cragan, J.; Thorpe, P.; Correa, A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S214
EP S214
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601135
ER
PT J
AU Theis, KA
Murphy, L
AF Theis, K. A.
Murphy, L.
TI LABOR FORCE STATUS AMONG US ADULTS 45-64 YEARS WITH AND WITHOUT
ARTHRITIS, 2002-2009
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Theis, K. A.; Murphy, L.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 1
Z9 1
U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S330
EP S330
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601580
ER
PT J
AU Eke, PI
Jaramillo, F
Thornton-Evans, GO
Borgnakke, WS
AF Eke, Paul I.
Jaramillo, Freder
Thornton-Evans, Gina O.
Borgnakke, Wenche S.
TI Dental visits among adult Hispanics - BRFSS 1999 and 2006
SO JOURNAL OF PUBLIC HEALTH DENTISTRY
LA English
DT Article
DE Hispanic Americans; adults; dental care; healthcare surveys; population
surveillance
ID ORAL-HEALTH; SERVICES
AB Objectives: This study examined and compared utilization of dental services by adult US Hispanics 18 years and older in the years 1999 and 2006.
Methods: Dental utilization data collected by telephone interviews by the state-based Behavioral Risk Factor Surveillance System (BRFSS) were analyzed.
Results: In 2006, the state mean and median prevalence of adult Hispanics with dental visits during the past year were 56.2 percent and 62.1 percent, respectively, and had not changed significantly since 1999. In 40 states, utilization was well below the national prevalence of 70.3 percent. Frequency of dental visits was significantly higher among females and those with higher income (>$50,000), higher education, nonsmokers, and persons having medical health insurance.
Conclusions: Findings from this study suggest that barriers to utilization of dental services among Hispanic adults exist in most states and may contribute to existing oral health disparities. The magnitude of this problem may increase in the future with the expansion of the US Hispanic population.
C1 [Eke, Paul I.; Jaramillo, Freder; Thornton-Evans, Gina O.] Ctr Dis Control & Prevent CDC, Div Oral Hlth, Natl Ctr Chron Dis & Hlth Promot, Atlanta, GA USA.
[Borgnakke, Wenche S.] Univ Michigan, Sch Dent, Ann Arbor, MI 48109 USA.
RP Eke, PI (reprint author), Ctr Dis Control & Prevent, Div Oral Hlth, Natl Ctr Chron Dis & Hlth Promot, Rhodes Bldg,Mail Stop F-10, Atlanta, GA 30341 USA.
EM peke@cdc.gov
NR 13
TC 2
Z9 2
U1 1
U2 5
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0022-4006
J9 J PUBLIC HEALTH DENT
JI J. Public Health Dent.
PD SUM
PY 2011
VL 71
IS 3
BP 252
EP 256
DI 10.1111/j.1752-7325.2011.00259.x
PG 5
WC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational
Health
SC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational
Health
GA 811OZ
UT WOS:000294223100011
PM 21972467
ER
PT J
AU Eick, AA
Uyeki, TM
Klimov, A
Hall, H
Reid, R
Santosham, M
O'Brien, KL
AF Eick, Angelia A.
Uyeki, Timothy M.
Klimov, Alexander
Hall, Henrietta
Reid, Raymond
Santosham, Mathuram
O'Brien, Katherine L.
TI Maternal Influenza Vaccination and Effect on Influenza Virus Infection
in Young Infants EDITORIAL COMMENT
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Editorial Material
AB It is recommended that pregnant women receive influenza vaccine because of their increased risk for influenza complications. Several prospective US-based observational studies concluded that maternal influenza vaccination delays the age at first infection and reduces severity of influenza illness; one randomized trial reported that vaccination reduced the incidence of laboratory-confirmed influenza.
This nonrandomized, prospective, observational cohort study investigated the effect of seasonal influenza vaccination in pregnant women on the occurrence of influenza virus infection in infants to 6 months of age. Participants were 1160 mother-infant pairs with mothers who delivered one infant during 3 influenza seasons between 2002 and 2005 at the Navajo and White Mountain Apache Indian reservations. Serum specimens from the infants of women who were unvaccinated (n = 587) and vaccinated (n = 573) were collected and analyzed. The primary study outcome measures in infants were laboratory-confirmed influenza, with influenza-like illness (ILI), ILI hospitalization, and elevated influenza hemagglutinin inhibition antibody titers.
Among the 1160 infants, 193 (17%) were hospitalized for ILI, 412 (36%) had only an outpatient ILI visit, and 555 (48%) had no ILI episodes. The ILI incidence rate was 7.2 per 1000 person-days for infants born to unvaccinated women and 6.7 per 1000 person-days for those born to vaccinated women. Compared with infants of unvaccinated women, there was a 41% reduction in the risk of laboratory-confirmed influenza virus infection (relative risk, 0.59; 95% confidence interval, 0.37-0.93) and a 39% reduction in the risk of hospitalization for ILI (relative risk, 0.61; 95% confidence interval, 0.45-0.84) among infants of vaccinated women. Moreover, hemagglutinin inhibition antibody titers to each of the 8 influenza virus antigens tested at birth and at 2 to 3 months of age were significantly higher in infants born to mothers vaccinated during pregnancy.
These findings show that maternal influenza vaccination increased influenza antibody titers in infants through 2 to 3 months of age, reducing their risk of both influenza virus infection and ILI hospitalization during the first 6 months of life. These data demonstrate the public health importance of maternal influenza vaccination.
C1 [Eick, Angelia A.] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Amer Indian Hlth, Baltimore, MD 21205 USA.
Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
RP Eick, AA (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Amer Indian Hlth, Baltimore, MD 21205 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7828
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD JUN
PY 2011
VL 66
IS 6
BP 333
EP 334
DI 10.1097/OGX.0b013e31822c17b0
PG 2
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 809KP
UT WOS:000294054100003
ER
PT J
AU Kemberling, M
Hagan, K
Leston, J
Kitka, S
Provost, E
Hennessy, T
AF Kemberling, Melissa
Hagan, Kyla
Leston, Jessica
Kitka, Sassa
Provost, Ellen
Hennessy, Thomas
TI Alaska Native adolescent views on cervical cancer, the human
papillomavirus (HPV), genital warts and the quadrivalent HPV vaccine
SO INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
LA English
DT Article
DE Alaska Natives; adolescents; cervical cancer; genital warts; HPV;
quadrivalent HPV vaccine
AB Objectives. To understand the knowledge levels, attitudes and perceptions of Alaska Native adolescent girls about cervical cancer, HPV, genital warts and the FIPV vaccine.
Study design. A qualitative study.
Methods. Seventy-nine in-depth interviews were conducted with adolescent females aged 11 through 18 years in 4 communities in Alaska. The convenience sample was recruited through word of mouth, posters and flyers distributed in community schools, medical clinics and stores.
Results. Many of those surveyed didn't know the purpose of a vaccine and were not familiar with basic knowledge about HPV, genital warts and cervical cancer. After learning about cervical cancer and HPV, most teens felt that someone their age had an average likelihood of contracting the diseases and that having the disease would be quite bad. Most teens said they were interested in vaccination. When asked if they would get a vaccine, older teens most commonly cited concerns about side effects or doubts about vaccine efficacy, while younger teens were afraid the shot would hurt. Most teens stated that they preferred to learn about health topics such as these through television programming, followed by the Internet, brochures and posters.
Conclusions. The findings provide valuable information on how to inform adolescents about the vaccine and alleviate their concerns. The design of an educational campaign should vary depending on the age of the adolescents. For younger teens, distribution of information should be at school using a brochure or curriculum, while for older teens a web page may be more appropriate. (Jut J Circumpolar Health 2011; 70(3):245-253)
C1 [Kemberling, Melissa; Provost, Ellen] Alaska Native Tribal Hlth Consortium, Alaska Native Epidemiol Ctr, Anchorage, AK 99508 USA.
[Hagan, Kyla] Alaska Native Tribal Hlth Consortium, Wellness & Prevent Program, Anchorage, AK 99508 USA.
[Leston, Jessica] Alaska Native Tribal Hlth Consortium, HIV STD Prevent Ctr, Anchorage, AK 99508 USA.
[Kitka, Sassa; Hennessy, Thomas] Ctr Dis Control & Prevent, Arctic Invest Program, Natl Ctr Preparedness Detect & Control Infect Dis, Anchorage, AK USA.
RP Kemberling, M (reprint author), Alaska Native Tribal Hlth Consortium, Alaska Native Epidemiol Ctr, 4000 Ambassador Dr, Anchorage, AK 99508 USA.
EM mmkemberling@anthc.org
NR 6
TC 3
Z9 3
U1 0
U2 4
PU INT ASSOC CIRCUMPOLAR HEALTH PUBL
PI OULU
PA AAPISTIE1, OULU, FIN-90220, FINLAND
SN 1239-9736
J9 INT J CIRCUMPOL HEAL
JI Int. J. Circumpolar Health
PD JUN
PY 2011
VL 70
IS 3
BP 245
EP 253
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 808QX
UT WOS:000293994600005
PM 21703130
ER
PT J
AU Lowenthal, P
Westenhouse, J
Moore, M
Posey, DL
Watt, JP
Flood, J
AF Lowenthal, P.
Westenhouse, J.
Moore, M.
Posey, D. L.
Watt, J. P.
Flood, J.
TI Reduced importation of tuberculosis after the implementation of an
enhanced pre-immigration screening protocol
SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
LA English
DT Article
DE immigration; tuberculosis screening; tuberculosis prevention and control
ID FOREIGN-BORN PERSONS; US-BOUND IMMIGRANTS; UNITED-STATES; REFUGEES;
CALIFORNIA
AB SETTING: Importation of infectious tuberculosis (TB) threatens TB control in California and the United States.
OBJECTIVE: To assess the effectiveness of an enhanced pre-immigration screening and treatment protocol to prevent the importation of infectious TB.
DESIGN: Retrospective analysis of immigrants years of age with TB suspect classifications who were screened for TB in their countries of origin before (pre-intervention cohort) and after (post-intervention cohort) implementation of enhanced pre-immigration screening. Enhanced pre-immigration screening added sputum cultures to the existing screening system based on sputum smears for persons with abnormal chest radiographs.
RESULTS: The pre- and post-intervention cohorts included respectively 2049 and 1430 immigrants. The occurrence of tuberculosis 6 months after US arrival in this population decreased following the intervention, from 4.2% (86 cases) to 1.5% (22 cases, P < 0.001). Among pre-intervention cohort cases, 14% were sputum acid-fast bacilli (AFB) smear-positive and 81% were sputum culture-positive for TB, compared with 5% sputum AFB smear-positive (P = 0.46) and 68% sputum culture-positive (P = 0.18) among the post-intervention cohort cases.
CONCLUSION: The enhanced pre-immigration screening was associated with a decline in the proportion of immigrants with TB suspect classifications identified with TB within 6 months of arrival in the United States. Continued state and national surveillance is critical to monitor the effectiveness of the revised pre-immigration screening as it is implemented in additional countries.
C1 [Lowenthal, P.] Calif Dept Publ Hlth, Div Communicable Dis Control, Ctr Infect Dis, TB Control Branch, Richmond, CA 94804 USA.
[Moore, M.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA.
[Posey, D. L.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA.
RP Lowenthal, P (reprint author), Calif Dept Publ Hlth, Div Communicable Dis Control, Ctr Infect Dis, TB Control Branch, 2nd Floor,850 Marina Bay Pkwy, Richmond, CA 94804 USA.
EM phil.lowenthal@cdph.ca.gov
NR 33
TC 22
Z9 22
U1 0
U2 2
PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
PI PARIS
PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE
SN 1027-3719
J9 INT J TUBERC LUNG D
JI Int. J. Tuberc. Lung Dis.
PD JUN
PY 2011
VL 15
IS 6
BP 761
EP 766
DI 10.5588/ijtld.10.0370
PG 6
WC Infectious Diseases; Respiratory System
SC Infectious Diseases; Respiratory System
GA 805KH
UT WOS:000293724800010
PM 21575295
ER
PT J
AU Katz, JM
Hancock, K
Xu, XY
AF Katz, Jacqueline M.
Hancock, Kathy
Xu, Xiyan
TI Serologic assays for influenza surveillance, diagnosis and vaccine
evaluation
SO EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
LA English
DT Review
DE antigenic characterization; hemagglutination inhibition; influenza
virus; vaccine responses; virus neutralization
ID SINGLE-RADIAL-HEMOLYSIS; A H1N1 VIRUS; LINKED-IMMUNOSORBENT-ASSAY;
HEMAGGLUTINATION-INHIBITING ANTIBODY; ERYTHROCYTE BINDING PREFERENCE;
RANDOMIZED CONTROLLED-TRIAL; WILD-TYPE VIRUS; AVIAN INFLUENZA;
RECEPTOR-BINDING; SERUM ANTIBODY
AB Serological techniques play a critical role in various aspects of influenza surveillance, vaccine development and evaluation, and sometimes in diagnosis, particularly for novel influenza virus infections of humans. Because individuals are repeatedly exposed to antigenically and genetically diverse influenza viruses over a lifetime, the gold standard for detection of a recent influenza virus infection or response to current vaccination is the demonstration of a seroconversion, a fourfold or greater rise in antibody titer relative to a baseline sample, to a circulating influenza strain or vaccine component. The hemagglutination-inhibition assay remains the most widely used assay to detect strain-specific serum antibodies to influenza. The hemagglutination-inhibition assay is also used to monitor antigenic changes among influenza viruses which are constantly evolving; such antigenic data is essential for consideration of changes in influenza vaccine composition. The use of the hemagglutinin-specific microneutralization assay has increased, in part, owing to its sensitivity for detection of human antibodies to novel influenza viruses of animal origin. Neutralization assays using replication-incompetent pseudotyped particles may be advantageous in some laboratory settings for detection of antibodies to influenza viruses with heightened biocontainment requirements. The use of standardized protocols and antibody standards are important steps to improve reproducibility and interlaboratory comparability of results of serologic assays for influenza viruses.
C1 [Katz, Jacqueline M.; Hancock, Kathy; Xu, Xiyan] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Katz, JM (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd, Atlanta, GA 30333 USA.
EM jkatz@cdc.gov
FU GlaxoSmithKline; Nobilon-Merck Sharp and Dohme; Juvaris, Inc.
FX Jacqueline M Katz has received research funding from GlaxoSmithKline,
Nobilon-Merck Sharp and Dohme and Juvaris, Inc. Kathy Hancock has
received research funding from GlaxoSmithKline and Juvaris Inc. The
authors have no other relevant affiliations or financial involvement
with any organization or entity with a financial interest in or
financial conflict with the subject matter or materials discussed in the
manuscript apart from those disclosed.
NR 165
TC 79
Z9 82
U1 3
U2 19
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
ENGLAND
SN 1478-7210
J9 EXPERT REV ANTI-INFE
JI Expert Rev. Anti-Infect. Ther.
PD JUN
PY 2011
VL 9
IS 6
BP 669
EP 683
DI 10.1586/ERI.11.51
PG 15
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 796VV
UT WOS:000293082500011
PM 21692672
ER
PT J
AU Hwang, KP
Huang, YC
Banyai, K
Wu, HS
Chang, FY
Yang, DCF
Hsiung, CA
Lin, JS
Jiang, B
Gentsch, JR
Wu, FT
AF Hwang, K. -P.
Huang, Y. -C.
Banyai, K.
Wu, H. -S.
Chang, F. -Y.
Yang, D. C. -F.
Hsiung, C. A.
Lin, J. -S.
Jiang, B.
Gentsch, J. R.
Wu, F. -T.
TI Severe gastroenteritis associated with G3P[9] rotavirus in Taiwan
SO INFECTION
LA English
DT Article
ID UNITED-STATES; CHILDREN; STRAINS; SEROTYPE; DIVERSITY; DISEASE; RARE;
EPIDEMIOLOGY; PROGRAMS; DIARRHEA
C1 [Wu, F. -T.] Ctr Dis Control, Epidem Intelligence Ctr, Dept Hlth, Taipei, Taiwan.
[Hwang, K. -P.] Chang Gung Univ, Div Pediat Infect Dis, Kaohsiung Med Ctr, Chang Gung Mem Hosp,Dept Pediat,Coll Med, Kaohsiung, Taiwan.
[Hwang, K. -P.] China Med Univ & Hosp, Sch Med, Childrens Hosp, Taichung, Taiwan.
[Huang, Y. -C.] Chang Gung Univ, Div Pediat Infect Dis, Chang Gung Childrens Hosp, Coll Med, Tao Yuan, Taiwan.
[Banyai, K.] Hungarian Acad Sci, Vet Med Res Inst, H-1581 Budapest, Hungary.
[Wu, H. -S.; Chang, F. -Y.; Yang, D. C. -F.] Ctr Dis Control, Ctr Res & Diagnost, Dept Hlth, Taipei, Taiwan.
[Wu, H. -S.] Taipei Med Univ, Sch Med Lab Sci & Biotechnol, Taipei, Taiwan.
[Hsiung, C. A.] Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Taiwan.
[Lin, J. -S.] Changhua Christian Hosp, Dept Lab Med, Changhua, Taiwan.
[Lin, J. -S.] Changhua Christian Hosp, Div Pediat Infect Dis, Changhua, Taiwan.
[Jiang, B.; Gentsch, J. R.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA.
RP Wu, FT (reprint author), Ctr Dis Control, Epidem Intelligence Ctr, Dept Hlth, Taipei, Taiwan.
EM fang@cdc.gov.tw
RI Hsiung, Chao Agnes/E-3994-2010;
OI Banyai, Krisztian/0000-0002-6270-1772
FU Centers for Disease Control, Department of Health, Taipei, Taiwan
[96-0324-01-F-0]; [DOH97-DC-1102]
FX This study was financially supported in part by research grant
DOH97-DC-1102 and an award from "The National Research Program for
Genome Medicine" (96-0324-01-F-0) from the Centers for Disease Control,
Department of Health, Taipei, Taiwan.
NR 22
TC 5
Z9 5
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8126
J9 INFECTION
JI Infection
PD JUN
PY 2011
VL 39
IS 3
BP 271
EP 275
DI 10.1007/s15010-011-0098-4
PG 5
WC Infectious Diseases
SC Infectious Diseases
GA 798IU
UT WOS:000293197600013
PM 21424852
ER
PT J
AU Pfaller, MA
Diekema, DJ
Andes, D
Arendrup, MC
Brown, SD
Lockhart, SR
Motyl, M
Perlin, DS
AF Pfaller, M. A.
Diekema, D. J.
Andes, D.
Arendrup, M. C.
Brown, S. D.
Lockhart, S. R.
Motyl, M.
Perlin, D. S.
CA CLSI Subcomm Antifungal Testing
TI Clinical breakpoints for the echinocandins and Candida revisited:
Integration of molecular, clinical, and microbiological data to arrive
at species-specific interpretive criteria
SO DRUG RESISTANCE UPDATES
LA English
DT Review
DE Candida; Echinocandins; Susceptibility testing
ID IN-VITRO ACTIVITY; EPIDEMIOLOGIC CUTOFF VALUES; LIPOSOMAL
AMPHOTERICIN-B; DOUBLE-BLIND TRIAL; INVASIVE CANDIDIASIS; ESOPHAGEAL
CANDIDIASIS; REDUCED SUSCEPTIBILITY; AZOLE RESISTANCE;
(1,3)-BETA-D-GLUCAN SYNTHASE; 1,3-BETA-D-GLUCAN SYNTHASE
AB The CLSI established clinical breakpoints (CBPs) for caspofungin (CSF), micafungin (MCF) and anidulafungin (ANF) versus Candida. The same CBP (susceptible (S): MIC <= 2 mcg/ml; non-S: MIC > 2 mcg/ml) was applied to all echinocandins and species. More data now allow reassessment of these CBPs.
We examined cases of echinocandin failure where both MICs and fks mutations were assessed; wild type (WT) MICs and epidemiological cutoff values (ECVs) fora large Candida collection; molecular analysis of fks hotspots for Candida with known MICs; and pharmacokinetic and pharmacodynamic (PK/PD) data. We applied these findings to propose new species-specific CBPs for echinocandins and Candida.
Of 18 candidiasis cases refractory to echinocandins and with fks mutations, 28% (CSF), 58% (ANF) and 66% (MCF) had MICs in the S category using CBP of <= 2 mcg/ml, while 0-8% would be S using CBP of <= 0.25 mcg/ml. WT MIC distributions revealed ECV ranges of 0.03-0.25 mcg/ml for all major species except C. parapsilosis (1-4 mcg/ml) and C. guilliermondii (4-16 mcg/ml). Among Candida tested for fks mutations, only 15.7-45.1% of 51 mutants were detected using the CBP for NS of > 2 mcg/ml. In contrast, a cutoff of > 0.25 mcg/ml for C. albicans, C. tropicalis, C. krusei, and C. dubliniensis detected 85.6% (MCF) to 95.2% (CSF) of 21 mutant strains. Likewise, a cutoff of > 0.12 mcg/ml for ANF and CSF and of > 0.06 mcg/ml for MCF detected 93% (ANF) to 97% (CSF, MCF) of 30 mutant strains of C. glabrata. These data, combined with PK/PD considerations, support CBPs of <= 0.25 mcg/ml (S), 0.5 mcg/ml (I), >= 1 (R) for CSF/MCF/ANF and C. albicans, C. tropicalis and C krusei and <= 2 mcg/ml (S), 4 mcg/ml (I), and 28 mcg/ml (R) for these agents and C. parapsilosis. The CBPs for ANF and CSF and C glabrata are <= 0.12 mcg/ml (S), 0.25 mcg/ml (I), and >= 0.5 mcg/ml (R), whereas those for MCF are <= 0.06 mcg/ml (S), 0.12 mcg/ml (I), and >= 0.25 mcg/ml (R).
New, species-specific CBPs for Candida and the echinocandins are more sensitive to detect emerging resistance associated with fks mutations, and better able to predict risk for clinical failure. (c) 2011 Elsevier Ltd. All rights reserved.
C1 [Pfaller, M. A.] Univ Iowa, Coll Med, Dept Pathol, Div Med Microbiol, Iowa City, IA 52242 USA.
[Andes, D.] Univ Wisconsin, Madison, WI USA.
[Arendrup, M. C.] Statens Serum Inst, DK-2300 Copenhagen, Denmark.
[Brown, S. D.] Inst Clin Microbiol, Wilsonville, OR USA.
[Lockhart, S. R.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Motyl, M.] Merck & Co Inc, Rahway, NJ 07065 USA.
[Perlin, D. S.] Univ Med & Dent New Jersey, New Jersey Med Sch, Publ Hlth Res Inst, Newark, NJ 07103 USA.
RP Pfaller, MA (reprint author), Univ Iowa, Coll Med, Dept Pathol, Div Med Microbiol, C606 GH, Iowa City, IA 52242 USA.
EM michael-pfaller@uiowa.edu
OI Diekema, Daniel/0000-0003-1273-0724
FU Astellas; Merck; Pfizer
FX This work was supported in part by grants from Astellas, Merck, and
Pfizer.
NR 98
TC 177
Z9 181
U1 0
U2 10
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1368-7646
J9 DRUG RESIST UPDATE
JI Drug Resist. Update
PD JUN
PY 2011
VL 14
IS 3
BP 164
EP 176
DI 10.1016/j.drup.2011.01.004
PG 13
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 790XD
UT WOS:000292623200003
PM 21353623
ER
PT J
AU Wise, ME
Weber, SG
Schneider, A
Stojcevski, M
France, AM
Schaefer, MK
Lin, MY
Kallen, AJ
Cochran, RL
AF Wise, Matthew E.
Weber, Stephen G.
Schneider, Amy
Stojcevski, Meg
France, Anne Marie
Schaefer, Melissa K.
Lin, Michael Y.
Kallen, Alexander J.
Cochran, Ronda L.
TI Hospital Staff Perceptions of a Legislative Mandate for
Methicillin-Resistant Staphylococcus aureus Screening
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Article
ID ACTIVE SURVEILLANCE CULTURES; CARE; PRECAUTIONS; INFECTION
AB OBJECTIVE. In August 2007, Illinois passed legislation mandating methicillin-resistant Staphylococcus aureus (MRSA) admission screening for intensive care unit patients. We assessed hospital staff perceptions of the implementation of this law.
DESIGN. Mixed-methods evaluation using structured focus groups and questionnaires.
SETTING. Eight Chicago-area hospitals. PARTICIPANTS. Three strata of staff (leadership, midlevel, and frontline) at each hospital.
METHODS. All participants completed a questionnaire and participated in a focus group. Focus group transcripts were thematically coded and analyzed. The proportion of staff agreeing with statements about MRSA and the legislation was compared across staff types.
RESULTS. Overall, 126 hospital staff participated in 23 focus groups. Fifty-six percent of participants agreed that the legislation had a positive effect at their facility; frontline staff were more likely to agree than midlevel and leadership staff (P <. 01). Perceived benefits of the legislation included increased awareness of MRSA among staff and better knowledge of the epidemiology of MRSA colonization. Perceived negative consequences included the psychosocial effect of screening and contact precautions on patients and increased use of resources. Most participants (59%) would choose to continue the activities associated with the legislation but advised facilities in states considering similar legislation to educate staff and patients about MRSA screening and to draft clear implementation plans.
CONCLUSION. Staff from Chicago-area hospitals perceived that mandatory MRSA screening legislation resulted in some benefits but highlighted implementation challenges. States considering similar initiatives might minimize these challenges by optimizing messaging to patients and healthcare staff, drafting implementation plans, and developing program evaluation strategies. Infect Control Hosp Epidemiol 2011;32(6):573-578
C1 [Wise, Matthew E.; Schneider, Amy; Schaefer, Melissa K.; Kallen, Alexander J.; Cochran, Ronda L.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA.
[Weber, Stephen G.; Stojcevski, Meg] Univ Chicago, Med Ctr, Chicago, IL 60637 USA.
[France, Anne Marie] New York City Dept Hlth & Mental Hyg, New York, NY USA.
[Lin, Michael Y.] Rush Univ, Med Ctr, Chicago, IL 60612 USA.
RP Wise, ME (reprint author), CDC, Div Hlth Qual Promot, 1600 Clifton Rd,MS A-35, Atlanta, GA 30333 USA.
EM cxx4@cdc.gov
NR 15
TC 4
Z9 4
U1 0
U2 1
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0899-823X
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD JUN
PY 2011
VL 32
IS 6
BP 573
EP 578
DI 10.1086/660016
PG 6
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 791GQ
UT WOS:000292653500006
PM 21558769
ER
PT J
AU Magill, SS
Black, SR
Wise, ME
Kallen, AJ
Lee, SJ
Gardner, T
Husain, F
Srinivasan, A
Gerber, SI
Jhung, M
AF Magill, Shelley S.
Black, Stephanie R.
Wise, Matthew E.
Kallen, Alexander J.
Lee, Soo-Jeong
Gardner, Tracie
Husain, Farah
Srinivasan, Arjun
Gerber, Susan I.
Jhung, Michael
TI Investigation of an Outbreak of 2009 Pandemic Influenza A Virus (H1N1)
Infections among Healthcare Personnel in a Chicago Hospital
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Article
AB In May 2009, we investigated a hospital outbreak of pandemic H1N1 (pH1N1) infection among healthcare personnel (HCP). Thirteen (65%) of 20 HCP with pH1N1 infection had healthcare-associated cases, which were primarily attributed to transmission among HCP. Eleven (55%) of HCP with pH1N1 infection worked for 1 day or more after the onset of illness. Personnel working with mild illness may have contributed to transmission among HCP. Infect Control Hosp Epidemiol 2011;32(6):611-615
C1 [Magill, Shelley S.; Wise, Matthew E.; Kallen, Alexander J.; Lee, Soo-Jeong; Gardner, Tracie; Husain, Farah; Srinivasan, Arjun; Jhung, Michael] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Black, Stephanie R.; Gerber, Susan I.] Chicago Dept Publ Hlth, Chicago, IL USA.
[Gardner, Tracie] Alaska Div Publ Hlth, Anchorage, AK USA.
RP Magill, SS (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop A-24, Atlanta, GA 30333 USA.
EM smagill@cdc.gov
FU Office of Workforce and Career Development, Centers for Disease Control
and Prevention (CDC); Pfizer
FX Financial support. Office of Workforce and Career Development, Centers
for Disease Control and Prevention (CDC).; S.S.M. reports having
consulted for and having received grant support from Pfizer and having
received an honorarium from Astellas prior to commencing employment at
the CDC in 2007. All other authors report no conflicts of interest
relevant to this article.
NR 5
TC 2
Z9 2
U1 0
U2 1
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0899-823X
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD JUN
PY 2011
VL 32
IS 6
BP 611
EP 615
DI 10.1086/660097
PG 5
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 791GQ
UT WOS:000292653500012
PM 21558775
ER
PT J
AU Montgomery, JR
Carroll, RB
McCollum, AM
AF Montgomery, Jay R.
Carroll, Robert B.
McCollum, Andrea M.
TI Ocular Vaccinia: A Consequence of Unrecognized Contact Transmission
SO MILITARY MEDICINE
LA English
DT Article
ID SMALLPOX VACCINATION; SEXUAL CONTACT; COMPLICATIONS; INFECTION; THERAPY
AB A patient developed severe ocular vaccinia via autoinoculation after acquiring unrecognized contact-transmitted vaccinia from wrestling with vaccinated members of his unit. This case highlights both the need to reinforce infection-control measures among vaccinees and the need for providers to be familiar with the identification and treatment of cutaneous and ocular vaccinia infection.
C1 [Montgomery, Jay R.] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Washington, DC 20012 USA.
[Carroll, Robert B.] Womack Army Med Ctr, Dept Ophthalmol, Ft Bragg, NC 28310 USA.
[McCollum, Andrea M.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Atlanta, GA 30333 USA.
RP Montgomery, JR (reprint author), Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, 6900 Georgia Ave NW,Buillding 41,Room 21, Washington, DC 20012 USA.
NR 15
TC 1
Z9 1
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD JUN
PY 2011
VL 176
IS 6
BP 699
EP 701
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 792XN
UT WOS:000292783800023
PM 21702392
ER
PT J
AU Greene, SK
Kulldorff, M
Yin, RH
Yih, WK
Lieu, TA
Weintraub, ES
Lee, GM
AF Greene, Sharon K.
Kulldorff, Martin
Yin, Ruihua
Yih, W. Katherine
Lieu, Tracy A.
Weintraub, Eric S.
Lee, Grace M.
TI Near real-time vaccine safety surveillance with partially accrued data
SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
LA English
DT Article
DE influenza vaccine; near real-time surveillance; quality control; vaccine
safety
ID ADVERSE EVENTS; PROJECT
AB Purpose The Vaccine Safety Datalink (VSD) Project conducts near real-time vaccine safety surveillance using sequential analytic methods. Timely surveillance is critical in identifying potential safety problems and preventing additional exposure before most vaccines are administered. For vaccines that are administered during a short period, such as influenza vaccines, timeliness can be improved by undertaking analyses while risk windows following vaccination are ongoing and by accommodating predictable and unpredictable data accrual delays. We describe practical solutions to these challenges, which were adopted by the VSD Project during pandemic and seasonal influenza vaccine safety surveillance in 2009/2010.
Methods Adjustments were made to two sequential analytic approaches. The Poisson-based approach compared the number of pre-defined adverse events observed following vaccination with the number expected using historical data. The expected number was adjusted for the proportion of the risk window elapsed and the proportion of inpatient data estimated to have accrued. The binomial-based approach used a self-controlled design, comparing the observed numbers of events in risk versus comparison windows. Events were included in analysis only if they occurred during a week that had already passed for both windows.
Results Analyzing data before risk windows fully elapsed improved the timeliness of safety surveillance. Adjustments for data accrual lags were tailored to each data source and avoided biasing analyses away from detecting a potential safety problem, particularly early during surveillance.
Conclusions The timeliness of vaccine and drug safety surveillance can be improved by properly accounting for partially elapsed windows and data accrual delays. Copyright c 2011 John Wiley & Sons, Ltd.
C1 [Greene, Sharon K.; Kulldorff, Martin; Yin, Ruihua; Yih, W. Katherine; Lieu, Tracy A.; Lee, Grace M.] Harvard Univ, Sch Med, Dept Populat Med, Boston, MA 02215 USA.
[Greene, Sharon K.; Kulldorff, Martin; Yin, Ruihua; Yih, W. Katherine; Lieu, Tracy A.; Lee, Grace M.] Harvard Pilgrim Hlth Care Inst, Boston, MA 02215 USA.
[Weintraub, Eric S.] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA USA.
[Lee, Grace M.] Childrens Hosp Boston, Dept Lab Med, Boston, MA USA.
[Lee, Grace M.] Childrens Hosp Boston, Div Infect Dis, Boston, MA USA.
RP Greene, SK (reprint author), Harvard Univ, Sch Med, Dept Populat Med, 133 Brookline Ave,6th Floor, Boston, MA 02215 USA.
EM Sharon_Greene@harvardpilgrim.org
RI Kulldorff, Martin/H-4282-2011;
OI Kulldorff, Martin/0000-0002-5284-2993
FU Centers for Disease Control and Prevention (CDC) [200-2002-00732]
FX This work was supported by a subcontract with America's Health Insurance
Plans (AHIP) under contract 200-2002-00732 from the Centers for Disease
Control and Prevention (CDC). The authors thank the data managers at
each of the VSD sites for estimating the lag in inpatient data accrual
and for providing high-quality data for inclusion in near real-time
vaccine safety studies.
NR 19
TC 17
Z9 17
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1053-8569
J9 PHARMACOEPIDEM DR S
JI Pharmacoepidemiol. Drug Saf.
PD JUN
PY 2011
VL 20
IS 6
BP 583
EP 590
DI 10.1002/pds.2133
PG 8
WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
GA 790PI
UT WOS:000292601300004
PM 21538670
ER
PT J
AU Karem, KL
Reynolds, MG
AF Karem, Kevin L.
Reynolds, Mary G.
TI Protection from smallpox: beyond immune biomarkers
SO FUTURE VIROLOGY
LA English
DT Review
DE immune induction; lifelong immunity; monkeypox; protective immunity;
smallpox; vaccine
ID VACCINIA VIRUS; HUMAN MONKEYPOX; CELL-CULTURE; VACCINATION; OUTBREAK;
DURATION; INFECTION; HUMANS; RESPONSES; ANTIBODY
AB Since the eradication of smallpox, immunological studies of smallpox vaccine (vaccinia virus) have provided great gains in understanding immunology as well as depecting smallpox vaccine-derived immune responses. Despite this wealth of knowledge, two confounding problems remain. First, that surviving smallpox provides an individual with lifelong protective immunity, whereas vaccination may not, and second, that specific molecular correlates of protection against smallpox remain vague. Historical literature on smallpox and contemporary studies of other human infections with orthopoxviruses, such as monkeypox, indicate that vaccination may lower disease risks, but it does not provide complete protection against infection in all individuals. Factors impacting protective immunity include longevity of immunologic memory post-vaccination, challenge dose and differences in the challenge viruses, as well as route of exposure. This article discusses historical information regarding smallpox attack rates during outbreaks and contemporary views on aspects of vaccines and naturally occurring orthopoxvirus outbreaks as related to vaccine-derived immunity.
C1 [Karem, Kevin L.; Reynolds, Mary G.] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Poxvirus & Rabies Branch, Poxivirus Program, Atlanta, GA 30339 USA.
RP Karem, KL (reprint author), Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Poxvirus & Rabies Branch, Poxivirus Program, 1600 Clifton Rd, Atlanta, GA 30339 USA.
EM kkarem@cdc.gov
NR 49
TC 2
Z9 2
U1 1
U2 2
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
1QB, ENGLAND
SN 1746-0794
J9 FUTURE VIROL
JI Future Virol.
PD JUN
PY 2011
VL 6
IS 6
BP 709
EP 719
DI 10.2217/FVL.10.79
PG 11
WC Virology
SC Virology
GA 788DI
UT WOS:000292425200009
ER
PT J
AU Hirst, DVL
Gressel, MG
Flanders, WD
AF Hirst, Deborah V. L.
Gressel, Michael G.
Flanders, W. Dana
TI Short-Term Monitoring of Formaldehyde: Comparison of Two Direct-Reading
Instruments to a Laboratory-Based Method
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
LA English
DT Article
DE air sampling; direct-reading monitors; formaldehyde; instrument
comparison
ID HOMES
AB Airborne formaldehyde concentrations can be measured using several different techniques, including laboratory-based methods and direct-reading instruments. Two commercially available direct-reading instruments, an RKI Instruments Model FP-30 and a PPM Technology Formaldemeter htV, were compared with National Institute for Occupational Safety and Health Method 2016 in different test environments to determine if these direct-reading instruments can provide comparable results. The methods yielded the following mean concentrations for 47 samples: NIOSH Method 2016, 0.37 ppm; FP-30, 0.29 ppm; and htV, 0.34 ppm. Results from both of the direct-reading instruments were correlated with the laboratory-based method (R(2) = 0.78 for FP-30, and 0.902 for htV). Comparison of the means of the three methods showed that on average the FP-30 instrument (p < 0.001) differed statistically from NIOSH Method 2016, whereas the htV (p = 0.15) was not statistically different from the NIOSH method. Sensitivity and specificity tests demonstrated that the FP-30 had sensitivity above 60% to detect formaldehyde concentrations at all the cutoff levels tested, whereas the htV appeared to have greater sensitivity above 88% for the levels evaluated.
C1 [Hirst, Deborah V. L.; Gressel, Michael G.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA.
[Flanders, W. Dana] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
RP Hirst, DVL (reprint author), CDC NIOSH, 4676 Columbia Pkwy,MS R-5, Cincinnati, OH 45226 USA.
EM DHirst@cdc.gov
NR 15
TC 0
Z9 0
U1 1
U2 2
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1545-9624
J9 J OCCUP ENVIRON HYG
JI J. Occup. Environ. Hyg.
PD JUN
PY 2011
VL 8
IS 6
BP 357
EP 363
DI 10.1080/15459624.2011.578499
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 789OU
UT WOS:000292526000005
PM 21557128
ER
PT J
AU Ahrenholz, SH
Sylvain, DC
AF Ahrenholz, Steven H.
Sylvain, David C.
TI Deepwater Horizon Response Workers Exposure Assessment at the Source:
MC252 Well No. 1
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
LA English
DT Editorial Material
C1 [Ahrenholz, Steven H.] NIOSH, US Dept Hlth & Human Serv, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA.
[Ahrenholz, Steven H.; Sylvain, David C.] Hazard Evaluat & Tech Assistance Branch, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA.
RP Ahrenholz, SH (reprint author), NIOSH, US Dept Hlth & Human Serv, Ctr Dis Control & Prevent, Mailstop R-9,4676 Columbia Pkwy, Cincinnati, OH 45226 USA.
EM SAhrenholz@cdc.gov
NR 15
TC 0
Z9 0
U1 0
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1545-9624
J9 J OCCUP ENVIRON HYG
JI J. Occup. Environ. Hyg.
PD JUN
PY 2011
VL 8
IS 6
BP D43
EP D50
DI 10.1080/15459624.2011.575011
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 789OU
UT WOS:000292526000001
PM 21604224
ER
PT J
AU Creanga, AA
Kamimoto, L
Newsome, K
D'Mello, T
Jamieson, DJ
Zotti, ME
Arnold, KE
Baumbach, J
Bennett, NM
Farley, MM
Gershman, K
Kirschke, D
Lynfield, R
Meek, J
Morin, C
Reingold, A
Ryan, P
Schaffner, W
Thomas, A
Zansky, S
Finelli, L
Honein, MA
AF Creanga, Andreea A.
Kamimoto, Laurie
Newsome, Kimberly
D'Mello, Tiffany
Jamieson, Denise J.
Zotti, Marianne E.
Arnold, Kathryn E.
Baumbach, Joan
Bennett, Nancy M.
Farley, Monica M.
Gershman, Ken
Kirschke, David
Lynfield, Ruth
Meek, James
Morin, Craig
Reingold, Arthur
Ryan, Patricia
Schaffner, William
Thomas, Ann
Zansky, Shelley
Finelli, Lyn
Honein, Margaret A.
TI Seasonal and 2009 pandemic influenza A (H1N1) virus infection during
pregnancy: a population-based study of hospitalized cases
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE human; infectious; influenza; pregnancy; pregnancy complications;
seasonal influenza; 2009 pandemic influenza
ID UNITED-STATES; WOMEN; ILLNESS; IMPACT
AB We sought to describe characteristics of hospitalized reproductive-aged (15-44 years) women with seasonal (2005/2006 through 2008/2009) and 2009 pandemic influenza A (H1N1) virus infection. We used population-based data from the Emerging Infections Program in 10 US states, and compared characteristics of pregnant (n = 150) and nonpregnant (n = 489) seasonal, and pregnant (n = 489) and nonpregnant (n = 1088) pandemic influenza cases using chi(2) and Fisher's exact tests. Pregnant women represented 23.5% and 31.0% of all reproductive-aged women hospitalized for seasonal and pandemic influenza, respectively. Significantly more nonpregnant than pregnant women with seasonal (71.2% vs 36.0%) and pandemic (69.7% vs 31.9%) influenza had an underlying medical condition other than pregnancy. Antiviral treatment was significantly more common with pandemic than seasonal influenza for both pregnant (86.5% vs 24.0%) and nonpregnant (82.0% vs 55.2%) women. Pregnant women comprised a significant proportion of influenza-hospitalized reproductive-aged women, underscoring the importance of influenza vaccination during pregnancy.
C1 [Creanga, Andreea A.; Jamieson, Denise J.; Zotti, Marianne E.] Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30341 USA.
[Creanga, Andreea A.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA.
[Kamimoto, Laurie; D'Mello, Tiffany; Finelli, Lyn] Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA USA.
[Newsome, Kimberly; Honein, Margaret A.] Natl Ctr Birth Defects & Dev Disabil, Div Birth Defects & Dev Disabil, Atlanta, GA USA.
[Arnold, Kathryn E.] Georgia Dept Human Resources, Georgia Emerging Infect Program, Div Publ Hlth, Atlanta, GA USA.
[Farley, Monica M.] Emory Univ, Sch Med, Atlanta, GA USA.
[Baumbach, Joan] New Mexico Dept Hlth, Santa Fe, NM USA.
[Bennett, Nancy M.] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY 14642 USA.
[Bennett, Nancy M.] Monroe Cty Dept Publ Hlth, Rochester, NY USA.
[Zansky, Shelley] New York State Dept Hlth, Emerging Infect Program, Albany, NY USA.
[Gershman, Ken] Colorado Dept Publ Hlth & Environm, Denver, CO USA.
[Kirschke, David; Schaffner, William] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA.
[Lynfield, Ruth; Morin, Craig] Minnesota Dept Hlth, St Paul, MN USA.
[Meek, James] Yale Univ, Connecticut Emerging Infect Program, New Haven, CT USA.
[Reingold, Arthur] Calif Emerging Infect Program, Oakland, CA USA.
[Ryan, Patricia] Maryland Dept Hlth & Mental Hyg, Baltimore, MD USA.
[Thomas, Ann] Oregon Publ Hlth Div, Portland, OR USA.
RP Creanga, AA (reprint author), Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, 4770 Buford Hwy NE,Mail Stop K-23, Atlanta, GA 30341 USA.
EM acreanga@cdc.gov
FU Centers for Disease Control and Prevention; Association of Maternal and
Child Health Programs
FX Publication of this article was supported by the Centers for Disease
Control and Prevention and the Association of Maternal and Child Health
Programs.
NR 18
TC 24
Z9 25
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUN
PY 2011
VL 204
IS 6
SU 1
BP S38
EP S45
DI 10.1016/j.ajog.2011.02.037
PG 8
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 772AF
UT WOS:000291201100007
PM 21507375
ER
PT J
AU Stein, R
Grimes, TS
Malow, R
Stratford, D
Spielberg, F
Holtgrave, DR
AF Stein, Renee
Grimes, Tanisha S.
Malow, Robert
Stratford, Dale
Spielberg, Freya
Holtgrave, David R.
TI INTRODUCTION TO SPECIAL SUPPLEMENT MONITORING AND EVALUATION OF HIV
COUNSELING, TESTING AND REFERRAL (CTR) AND HIV TESTING SERVICES
SO AIDS EDUCATION AND PREVENTION
LA English
DT Editorial Material
ID UNITED-STATES; PREVALENCE; ADOLESCENTS; ADULTS
C1 [Stein, Renee; Grimes, Tanisha S.; Stratford, Dale] Ctr Dis Control & Prevent CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
[Malow, Robert] Florida Int Univ, Coll Hlth & Urban Affairs, N Miami, FL USA.
[Spielberg, Freya] Res Triangle Inst, Res Triangle Pk, NC 27709 USA.
[Holtgrave, David R.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD USA.
[Holtgrave, David R.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD USA.
RP Stein, R (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV STD & TB Prevent, 1600 Clifton Rd NE,Mail Stop E-59, Atlanta, GA 30333 USA.
EM arf7@cdc.gov
NR 12
TC 1
Z9 1
U1 0
U2 1
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0899-9546
J9 AIDS EDUC PREV
JI Aids Educ. Prev.
PD JUN
PY 2011
VL 23
IS 3
SU S
BP 1
EP 6
PG 6
WC Education & Educational Research; Public, Environmental & Occupational
Health
SC Education & Educational Research; Public, Environmental & Occupational
Health
GA 779FQ
UT WOS:000291763900001
PM 21689032
ER
PT J
AU Nguyen, TTH
Wolfe, MI
Dat, TT
McFarland, DA
Lamb, ML
Thang, NT
Thai, HN
Del Rio, C
AF Nguyen Thi Thu Hong
Wolfe, Mitchell I.
Tran Tien Dat
McFarland, Deborah A.
Lamb, Mary L.
Nguyen Trong Thang
Hoang Nam Thai
Del Rio, Carlos
TI UTILIZATION OF HIV VOLUNTARY COUNSELING AND TESTING IN VIETNAM: AN
EVALUATION OF 5 YEARS OF ROUTINE PROGRAM DATA FOR NATIONAL RESPONSE
SO AIDS EDUCATION AND PREVENTION
LA English
DT Article
ID SEXUAL RISK BEHAVIOR; UNITED-STATES; INFECTION; TRANSMISSION;
PREVENTION; COUPLES; SEROCONVERSION; NOTIFICATION; TANZANIA; THAILAND
AB This study evaluated the utilization of HIV voluntary counseling-and-testing (VCT) services targeting high-risk populations in Vietnam in order to inform decisions on program improvement and expansion. A total of 158,888 records collected from 55 VCT sites supported by the U.S. Centers for Disease Control and Prevention's Global AIDS Program in the period of 2002 to 2007 were used to analyze sociodemographic characteristics, risk exposures, seropositivity, test refusal, and failure to return for test results among VCT clients. High-risk exposures, such as injection drug use, commercial sex work, homosexual contacts or heterosexual contacts with high-risk sex partners, were reported in 126,815 (81%) records. Among high-risk clients, any condom use in the past month ranged from 34% to 71%. During the study period, 19% of the VCT encounters resulted in a positive HIV test; of those persons tested, 23% of men and 13% of women were HIV-positive. High HIV positivity rates were associated with injection drug use, being ill/recommended by health care provider, and having an HIV-infected sex partner. Of all records, 6.1% documented refusal of HIV testing. Failure to return for results was reported in 3.5% of records for clients who were tested. Previously testing positive was the strongest predictor of test refusal, and being referred by peer educators was associated with failure to return for results. The VCT program in Vietnam successfully targeted high-risk populations, and clients had high return rates using a standard testing strategy. Interventions to increase consistent condom use and promote access to prevention services among sex partners of high-risk individuals should be implemented and evaluated.
C1 [Nguyen Thi Thu Hong; Tran Tien Dat; Hoang Nam Thai] US Ctr Dis Control & Prevent CDC, Global AIDS Program, Hanoi, Vietnam.
[Wolfe, Mitchell I.] US CDC, Global AIDS Program, Asia Reg Off, Bangkok, Thailand.
[McFarland, Deborah A.; Del Rio, Carlos] Emory Univ, Atlanta, GA 30322 USA.
[Lamb, Mary L.] US CDC, Div STD Prevent, Atlanta, GA USA.
RP Nguyen, TTH (reprint author), DHHS CDC, US Embassy Hanoi, 7 Lang Ha St, Hanoi 1000, Vietnam.
EM nguyenht@vn.cdc.gov
RI del Rio, Carlos/B-3763-2012
OI del Rio, Carlos/0000-0002-0153-3517
NR 36
TC 0
Z9 0
U1 1
U2 2
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0899-9546
J9 AIDS EDUC PREV
JI Aids Educ. Prev.
PD JUN
PY 2011
VL 23
IS 3
SU S
BP 30
EP 48
PG 19
WC Education & Educational Research; Public, Environmental & Occupational
Health
SC Education & Educational Research; Public, Environmental & Occupational
Health
GA 779FQ
UT WOS:000291763900004
ER
PT J
AU Shrestha, RK
Sansom, SL
Schulden, JD
Song, BW
Smith, LC
Ramirez, R
Mares-DelGrasso, A
Heffelfinger, JD
AF Shrestha, Ram K.
Sansom, Stephanie L.
Schulden, Jeffrey D.
Song, Binwei
Smith, Linney C.
Ramirez, Ramon
Mares-DelGrasso, Azul
Heffelfinger, James D.
TI COSTS AND EFFECTIVENESS OF FINDING NEW HIV DIAGNOSES BY USING RAPID
TESTING IN TRANSGENDER COMMUNITIES
SO AIDS EDUCATION AND PREVENTION
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; UNITED-STATES; RISK BEHAVIORS; PREVALENCE;
MEN; SEX; ORGANIZATIONS; PREVENTION
AB We assessed the costs and effectiveness of rapid HIV testing services provided to transgender communities in New York City and San Francisco from April 2005 to December 2006. Program costs were estimated based on service provider's perspective and included the costs attributable to staff time, incentives, transportation, test kits, office space, equipment, supplies, and utilities. The average annual numbers of persons tested were 195 and 106 persons and numbers notified of new HIV diagnoses were 35 (18.2%) in New York City and 8 (7.3%) in San Francisco, respectively. The estimated annual program costs were $125,879 and $64,323 and average costs per person notified of new diagnosis were $3,563 and $8,284 in New York City and San Francisco, respectively. The primary reason for differences in program costs by site was differences in the proportion of undiagnosed HIV infection among persons tested. Our findings can inform decisions about program planning and allocation of limited HIV testing resources.
C1 [Shrestha, Ram K.; Sansom, Stephanie L.; Schulden, Jeffrey D.; Song, Binwei; Heffelfinger, James D.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
[Smith, Linney C.] Housing Works Inc, New York, NY USA.
[Ramirez, Ramon; Mares-DelGrasso, Azul] AIDS Healthcare Fdn, San Francisco, CA USA.
RP Shrestha, RK (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Mail Stop E48,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM rshrestha@cdc.gov
NR 24
TC 12
Z9 12
U1 0
U2 5
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0899-9546
J9 AIDS EDUC PREV
JI Aids Educ. Prev.
PD JUN
PY 2011
VL 23
IS 3
SU S
BP 49
EP 57
PG 9
WC Education & Educational Research; Public, Environmental & Occupational
Health
SC Education & Educational Research; Public, Environmental & Occupational
Health
GA 779FQ
UT WOS:000291763900005
PM 21689036
ER
PT J
AU Hutchinson, AB
Farnham, PG
Lyss, SB
White, DAE
Sansom, SL
Branson, BM
AF Hutchinson, Angela B.
Farnham, Paul G.
Lyss, Sheryl B.
White, Douglas A. E.
Sansom, Stephanie L.
Branson, Bernard M.
TI EMERGENCY DEPARTMENT HIV SCREENING WITH RAPID TESTS: A COST COMPARISON
OF ALTERNATIVE MODELS
SO AIDS EDUCATION AND PREVENTION
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; PERSONS AWARE; UNITED-STATES; CARE;
HEALTH; UNAWARE
AB Although previous studies have shown that HIV screening in emergency departments (EDs) is feasible, the costs and outcomes of alternative methods of implementing ED screening have not been examined. We compared the costs and outcomes of a model that used the hospital's ED staff to conduct screening, a supplemental staff model that used non-ED staff hired to conduct screening and a hypothetical hybrid model that combined aspects of both approaches. We developed a decision analytic model to estimate the cost per HIV-infected patient identified using alternative ED testing models. The cost per new HIV infection identified was $3,319, $2,084 and $1,850 under the supplemental, existing staff and hybrid models, respectively. Assuming an annual ED census of 50,000 patients, the existing staff model identified 29 more HIV infections than the supplemental model and the hybrid model identified 76 more infections than the existing staff model. Our findings suggest that a hybrid model should be favored over either a supplemental staff or existing staff model in terms of cost per outcome achieved.
C1 [Hutchinson, Angela B.; Farnham, Paul G.; Lyss, Sheryl B.; Sansom, Stephanie L.; Branson, Bernard M.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
[White, Douglas A. E.] Highland Hosp, Alameda Cty Med Ctr, Dept Emergency Med, Oakland, CA USA.
RP Hutchinson, AB (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV STD & TB Prevent, 1600 Clifton Rd NE,Mail Stop E-46, Atlanta, GA 30333 USA.
EM ahutchinson@cdc.gov
NR 24
TC 7
Z9 7
U1 3
U2 4
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0899-9546
J9 AIDS EDUC PREV
JI Aids Educ. Prev.
PD JUN
PY 2011
VL 23
IS 3
SU S
BP 58
EP 69
PG 12
WC Education & Educational Research; Public, Environmental & Occupational
Health
SC Education & Educational Research; Public, Environmental & Occupational
Health
GA 779FQ
UT WOS:000291763900006
PM 21689037
ER
PT J
AU Garland, PM
Valverde, EE
Fagan, J
Beer, L
Sanders, C
Hillman, D
Brady, K
Courogen, M
Bertolli, J
AF Garland, Pamela Morse
Valverde, Eduardo E.
Fagan, Jennifer
Beer, Linda
Sanders, Catherine
Hillman, Daniel
Brady, Kathleen
Courogen, Maria
Bertolli, Jeanne
CA NIC Study Grp
TI HIV COUNSELING, TESTING AND REFERRAL EXPERIENCES OF PERSONS DIAGNOSED
WITH HIV WHO HAVE NEVER ENTERED HIV MEDICAL CARE
SO AIDS EDUCATION AND PREVENTION
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; INFECTED PERSONS; UNITED-STATES; SERVICES;
PEOPLE; ACCESS; ENTRY; DELAY
AB The HIV counseling, testing, and referral (CTR) encounter represents an important opportunity to actively facilitate entry into medical care for those who test positive for HIV, but its potential is not always realized. Ways to improve facilitation of linkage to care through the CTR encounter haven't been explored among HIV-infected persons who have not entered care. We conducted 42 structured and qualitative interviews among HIV-infected persons, diagnosed 5-19 months previously, in Indiana, Philadelphia and Washington State, who had not received HIV medical care. Respondents related individual and system-level barriers, as well as recommendations for improving the effectiveness of CTR as a facilitator of linkage to HIV medical care through more active referrals, and for strengthening the bridge between CTR and linkage to care services. Our findings suggest that standards for active case referral by CTR staff and integration of CTR and linkage to care services are needed.
RP Garland, PM (reprint author), Ctr Dis Control & Prevent, MS E-46,1600 Clifton Rd NE, Atlanta, GA 30333 USA.
EM hge2@cdc.gov
NR 27
TC 12
Z9 12
U1 1
U2 7
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0899-9546
J9 AIDS EDUC PREV
JI Aids Educ. Prev.
PD JUN
PY 2011
VL 23
IS 3
SU S
BP 117
EP 127
PG 11
WC Education & Educational Research; Public, Environmental & Occupational
Health
SC Education & Educational Research; Public, Environmental & Occupational
Health
GA 779FQ
UT WOS:000291763900011
PM 21689042
ER
PT J
AU Chandwani, S
Abramowitz, S
Koenig, LJ
Barnes, W
D'Angelo, L
AF Chandwani, Sulachni
Abramowitz, Susan
Koenig, Linda J.
Barnes, William
D'Angelo, Lawrence
TI A MULTIMODAL BEHAVIORAL INTERVENTION TO IMPACT ADHERENCE AND RISK
BEHAVIOR AMONG PERINATALLY AND BEHAVIORALLY HIV-INFECTED YOUTH:
DESCRIPTION, DELIVERY, AND RECEPTIVITY OF ADOLESCENT IMPACT
SO AIDS EDUCATION AND PREVENTION
LA English
DT Article
ID DRUG-RESISTANCE; SEXUAL-BEHAVIOR; YOUNG-PEOPLE; SELF-REPORT; HEALTH;
EFFICACY; REACH
AB Secondary prevention programs are needed to help HIV-positive youth reduce risk behavior and improve adherence to HIV medications. This article provides an overview of Adolescent Impact, a secondary HIV prevention intervention, including its description, delivery, and receptivity among the two unique groups of participants. Adolescent Impact, a 12-session behavioral intervention incorporating individual and group components was designed to increase HIV knowledge, disease management and risk reduction skills, and motivate healthy lifestyles among HIV-infected adolescents. A standardized protocol was implemented at three sites in the northeastern United States. One hundred sixty-six HIV-positive youth, aged 13-21 (mean = 16.8 years), enrolled in the study were randomized to receive either the intervention (n = 83) or standard of care (n = 83). Participants were predominantly of minority race/ethnicity (94% African American or Hispanic); 53% were female and 59.6% were perinatally infected. Perinatally infected youth were significantly more likely to be young, had experienced HIV Class C-related symptoms and had CD4-positive T lymphocyte counts of fewer than 200 cells (all p values < .01). The mean number of sessions attended was 9.4, with most (83.3%) participants attending at least half (>= 6) of the intervention sessions (86% perinatally infected, 78.6% behaviorally infected, p = .5). Participants' sociodemographic and clinical characteristics mirrored those of the larger HIV adolescent cohort in the United States Relatively high attendance rates suggest that youth were receptive to the program and its content. Through use of multiple intervention modalities, Adolescent Impact was able to accommodate a diverse group of clinic-attending HIV-positive youth and address the need for a compact intervention for use in the clinical setting.
C1 [Chandwani, Sulachni] NYU, Sch Med, Dept Pediat, New York, NY 10016 USA.
[Koenig, Linda J.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA.
[Barnes, William; D'Angelo, Lawrence] Childrens Natl Med Ctr, Washington, DC 20010 USA.
RP Chandwani, S (reprint author), NYU, Sch Med, Dept Pediat, 550 1st Ave, New York, NY 10016 USA.
EM sulachni.chandwani@nyumc.org
FU PHS HHS [U64CCU319455, U64CCU219448, U64CCU319459]
NR 32
TC 10
Z9 10
U1 0
U2 6
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0899-9546
J9 AIDS EDUC PREV
JI Aids Educ. Prev.
PD JUN
PY 2011
VL 23
IS 3
BP 222
EP 235
PG 14
WC Education & Educational Research; Public, Environmental & Occupational
Health
SC Education & Educational Research; Public, Environmental & Occupational
Health
GA 779FP
UT WOS:000291763800003
PM 21696241
ER
PT J
AU Parker, ME
Bentley, ME
Chasela, C
Adair, L
Piwoz, EG
Jamieson, DJ
Ellington, S
Kayira, D
Soko, A
Mkhomawanthu, C
Tembo, M
Martinson, F
Van der Horst, CM
AF Parker, Megan E.
Bentley, Margaret E.
Chasela, Charles
Adair, Linda
Piwoz, Ellen G.
Jamieson, Denise J.
Ellington, Sascha
Kayira, Dumbani
Soko, Alice
Mkhomawanthu, Chimwemwe
Tembo, Martin
Martinson, Francis
Van der Horst, Charles M.
TI THE ACCEPTANCE AND FEASIBILITY OF REPLACEMENT FEEDING AT 6 MONTHS AS AN
HIV PREVENTION METHOD IN LILONGWE, MALAWI: RESULTS FROM THE BAN STUDY
SO AIDS EDUCATION AND PREVENTION
LA English
DT Article
ID TO-USE FOOD; UNINFECTED CHILDREN BORN; HOME-BASED THERAPY; INFECTED
MOTHERS; MICRONUTRIENT SUPPLEMENTS; COMPLEMENTARY FOODS; FORTIFIED
SPREADS; CLINICAL-TRIAL; SOUTH-AFRICA; BREAST-MILK
AB International guidelines recommend EBF to age 6 months among HIV-infected mothers choosing to breast-feed and cessation thereafter if replacement feeding is acceptable, feasible, affordable, sustainable, and safe. When mothers wean, they are challenged to provide an adequate replacement diet. This study investigates the use and acceptability of a lipid-based nutrient supplement (LNS) as a breast-milk substitute when provided to infants (6-12mo) of HIV-positive mothers, as part of the Breast-feeding, Antiretroviral, and Nutrition (BAN) Study. A sub-sample of mothers (n = 45) participated in interviews that explored EBF, weaning, and strategies to feed LNS. Mothers reported several weaning strategies, including gradual reduction of breast-feeding, expressing breast-milk into a cup, and separation of mother and child. LNS, a peanut-based micronutrient fortified paste, was highly accepted and incorporated into the traditional diet. Weaning is a feasible HIV prevention method among this population in Malawi when supported by the provision of LNS as a breast-milk substitute.
C1 [Parker, Megan E.; Bentley, Margaret E.; Adair, Linda; Van der Horst, Charles M.] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA.
[Piwoz, Ellen G.] Bill & Melinda Gates Fdn, Seattle, WA USA.
[Jamieson, Denise J.; Ellington, Sascha] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA.
[Chasela, Charles; Soko, Alice; Mkhomawanthu, Chimwemwe; Martinson, Francis] UNC Project, Lilongwe, Malawi.
[Tembo, Martin] Wageningen Univ, Wageningen, Netherlands.
RP Parker, ME (reprint author), IFPRI, 2033 K St NW, Washington, DC 20006 USA.
EM m.parker@cgiar.org
FU FIC NIH HHS [2-D43 TW01039-06, R24 TW007988]; NCCDPHP CDC HHS [26-04
U48-DP000059-01, U48 DP000059]; NIAID NIH HHS [P30 AI050410,
P30-AI50410]; NICHD NIH HHS [1R03HD057775-01, R03 HD057775, R03
HD057775-01, R24 HD050924]; PHS HHS [13-01 U48-CCU409660-09]
NR 41
TC 9
Z9 9
U1 0
U2 2
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 72 SPRING STREET, NEW YORK, NY 10012 USA
SN 0899-9546
J9 AIDS EDUC PREV
JI Aids Educ. Prev.
PD JUN
PY 2011
VL 23
IS 3
BP 281
EP 295
PG 15
WC Education & Educational Research; Public, Environmental & Occupational
Health
SC Education & Educational Research; Public, Environmental & Occupational
Health
GA 779FP
UT WOS:000291763800007
PM 21696245
ER
PT J
AU Grajewski, B
Waters, MA
Yong, LC
Tseng, CY
Zivkovich, Z
Cassinelli, RT
AF Grajewski, Barbara
Waters, Martha A.
Yong, Lee C.
Tseng, Chih-Yu
Zivkovich, Zachary
Cassinelli, Rick T., II
TI Airline Pilot Cosmic Radiation and Circadian Disruption Exposure
Assessment from Logbooks and Company Records
SO ANNALS OF OCCUPATIONAL HYGIENE
LA English
DT Article
DE circadian disruption; cosmic radiation; exposure assessment; flight
crew; pilots
ID FEMALE FLIGHT ATTENDANTS; CANCER INCIDENCE; RHYTHM DISRUPTION; DOSE
ESTIMATION; PUBLISHED DATA
AB Methods: Exposures were estimated for cosmic ionizing radiation and circadian disruption between August 1963 and March 2003 for 83 male pilots from a major US airline. Estimates were based on 523 387 individual flight segments in company records and pilot logbooks as well as summary records of hours flown from other sources. Exposure was estimated by calculation or imputation for all but 0.02% of the individual flight segments' block time. Exposures were estimated from questionnaire data for a comparison group of 51 male university faculty.
Results: Pilots flew a median of 7126 flight segments and 14 959 block hours for 27.8 years. In the final study year, a hypothetical pilot incurred an estimated median effective dose of 1.92 mSv (absorbed dose, 0.85 mGy) from cosmic radiation and crossed 362 time zones. This study pilot was possibly exposed to a moderate or large solar particle event a median of 6 times or once every 3.7 years of work. Work at the study airline and military flying were the two highest sources of pilot exposure for all metrics. An index of work during the standard sleep interval (SSI travel) also suggested potential chronic sleep disturbance in some pilots. For study airline flights, median segment radiation doses, time zones crossed, and SSI travel increased markedly from the 1990s to 2003 (P(trend) < 0.0001). Dose metrics were moderately correlated with records-based duration metrics (Spearman's r = 0.61-0.69).
Conclusions: The methods developed provided an exposure profile of this group of US airline pilots, many of whom have been exposed to increasing cosmic radiation and circadian disruption from the 1990s through 2003. This assessment is likely to decrease exposure misclassification in health studies.
C1 [Grajewski, Barbara; Waters, Martha A.; Yong, Lee C.; Tseng, Chih-Yu; Zivkovich, Zachary; Cassinelli, Rick T., II] Ctr Dis Control & Prevent, Industrywide Studies Branch, Div Surveillance Hazard Evaluat & Field Studies, NIOSH, Cincinnati, OH 45226 USA.
RP Grajewski, B (reprint author), Ctr Dis Control & Prevent, Industrywide Studies Branch, Div Surveillance Hazard Evaluat & Field Studies, NIOSH, 4676 Columbia Pkwy R-15, Cincinnati, OH 45226 USA.
EM BAG2@CDC.GOV
FU National Institute for Occupational Safety and Health (NIOSH)
[Y1CP802904]; National Cancer Institute [Y1CP802904]; Division of Cancer
Epidemiology and Genetics, National Cancer Institute.
FX This work was part of the Intramural Research Program of the National
Institute for Occupational Safety and Health (NIOSH). It was supported
in part by an interagency agreement between NIOSH and the National
Cancer Institute (contract Y1CP802904) and by the Intramural Research
Program of the Division of Cancer Epidemiology and Genetics, National
Cancer Institute.
NR 34
TC 20
Z9 20
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0003-4878
J9 ANN OCCUP HYG
JI Ann. Occup. Hyg.
PD JUN
PY 2011
VL 55
IS 5
BP 465
EP 475
DI 10.1093/annhyg/mer024
PG 11
WC Public, Environmental & Occupational Health; Toxicology
SC Public, Environmental & Occupational Health; Toxicology
GA 778ZG
UT WOS:000291747300002
PM 21610083
ER
PT J
AU Ford, ES
AF Ford, Earl S.
TI Trends in the Risk for Coronary Heart Disease Among Adults With
Diagnosed Diabetes in the US Findings from the National Health and
Nutrition Examination Survey, 1999-2008
SO DIABETES CARE
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; UNITED-KINGDOM; FRAMINGHAM; EQUATIONS;
PREDICTION; ENGINE; HYPERTENSION; MORTALITY; MELLITUS; ADVANCE
AB OBJECTIVE-Coronary heart disease (CHD) is a major cause of mortality among people with diabetes. The objective of this study was to examine the trend in an estimated 10-year risk for developing CHD among adults with diagnosed diabetes in the U.S.
RESEARCH DESIGN AND METHODS-Data from 1,977 adults, aged 30-79 years, with diagnosed diabetes who participated in the National Health and Nutrition Examination Survey from 1999-2000 to 2007-2008 were used. Estimated risk was calculated using risk prediction algorithms from the UK Prospective Diabetes Study (UKPDS), the Atherosclerosis Risk in Communities study, and the Framingham Heart Study.
RESULTS-Significant improvements in mean HbA(1c) concentrations, systolic blood pressure, and the ratio of total cholesterol to HDL cholesterol occurred. No significant linear trend for current smoking status was observed. The estimated UKPDS 10-year risk for CHD was 21.1% in 1999-2000 and 16.4% in 2007-2008 (P(linear trend) < 0.001). The risk decreased significantly among men, women, whites, African Americans, and Mexican Americans.
CONCLUSIONS-The estimated 10-year risk for CHD among adults with diabetes has improved significantly from 1999-2000 to 2007-2008. Sustained efforts in improving risk factors should further benefit the cardiovascular health of people with diabetes.
C1 Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
RP Ford, ES (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
EM eford@cdc.gov
NR 25
TC 58
Z9 59
U1 0
U2 5
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD JUN
PY 2011
VL 34
IS 6
BP 1337
EP 1343
DI 10.2337/dc10-2251
PG 7
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 780HX
UT WOS:000291846200017
PM 21505207
ER
PT J
AU Li, CY
Balluz, LS
Ford, ES
Okoro, CA
Tsai, J
Zhao, GX
AF Li, Chaoyang
Balluz, Lina S.
Ford, Earl S.
Okoro, Catherine A.
Tsai, James
Zhao, Guixiang
TI Association Between Diagnosed Diabetes and Self-Reported Cancer Among US
Adults Findings from the 2009 Behavioral Risk Factor Surveillance System
SO DIABETES CARE
LA English
DT Article
AB OBJECTIVE-To assess the association between diagnosed diabetes and self-reported cancer among U.S. adults.
RESEARCH DESIGN AND METHODS-We analyzed data for 397,783 adults who participated in the 2009 Behavioral Risk Factor Surveillance System and had valid data on diabetes and cancer.
RESULTS-After adjustment for potential confounders, diabetic men had higher adjusted prevalence ratios for cancers of the prostate (1.1 [95% CI 1.0-1.3]), colon (1.3 [1.0-1.7]), pancreas (4.6 [1.8-11.7]), rectum (2.2 [1.0-4.7]), urinary bladder (1.7 [1.2-2.2]), and kidney (1.9 [1.2-3.0]) than nondiabetic men (all P < 0.05). Diabetic women had higher adjusted prevalence ratios for cancers of the breast (1.1 [1.0-1.3]) and endometrium (1.6 [1.2-2.0]), and leukemia (2.3 [1.3-4.2]) than nondiabetic women (all P < 0.05).
CONCLUSIONS-Our results suggest that diabetic adults have higher prevalences of certain cancers than nondiabetic adults.
C1 [Li, Chaoyang; Balluz, Lina S.; Okoro, Catherine A.] Ctr Dis Control & Prevent, Div Behav Surveillance, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA.
[Ford, Earl S.; Zhao, Guixiang] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
[Tsai, James] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
RP Li, CY (reprint author), Ctr Dis Control & Prevent, Div Behav Surveillance, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA.
EM cli@cdc.gov
NR 11
TC 23
Z9 24
U1 1
U2 4
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD JUN
PY 2011
VL 34
IS 6
BP 1365
EP 1368
DI 10.2337/dc11-0020
PG 4
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 780HX
UT WOS:000291846200022
PM 21505205
ER
PT J
AU Dahm, MM
Yencken, MS
Schubauer-Berigan, MK
AF Dahm, Matthew M.
Yencken, Marianne S.
Schubauer-Berigan, Mary K.
TI Exposure Control Strategies in the Carbonaceous Nanomaterial Industry
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article; Proceedings Paper
CT Conference on Medical Surveillance, Exposure Registries, and
Epidemiologic Research
CY JUL 21-23, 2010
CL Keystone, CO
SP Natl Inst Occupation Safety & Hlth (NIOSH)
ID NANOTUBES
AB Objective: Little is known about exposure control strategies currently being implemented to minimize exposures during the production or use of nanomaterials in the United States. Our goal was to estimate types and quantities of materials used and factors related to workplace exposure reductions among companies manufacturing or using engineered carbonaceous nanomaterials (ECNs). Methods: Information was collected through phone surveys on work practices and exposure control strategies from 30 participating producers and users of ECN. The participants were classified into three groups for further examination. Results: We report here the use of exposure control strategies. Observed patterns suggest that large-scale manufacturers report greater use of nanospecific exposure control strategies particularly for respiratory protection. Conclusion: Workplaces producing or using ECN generally report using engineering and administrative controls as well as personal protective equipment to control workplace employee exposure.
C1 [Dahm, Matthew M.; Schubauer-Berigan, Mary K.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Industrywide Studies Branch, Cincinnati, OH 45226 USA.
[Yencken, Marianne S.] Battelle Ctr Publ Hlth Res & Evaluat, Seattle, WA USA.
RP Dahm, MM (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Industrywide Studies Branch, 4676 Columbia Pkwy,MS-R14, Cincinnati, OH 45226 USA.
EM mdahm@cdc.gov
RI Schubauer-Berigan, Mary/B-3149-2009; Dahm, Matthew/I-2131-2012
OI Schubauer-Berigan, Mary/0000-0002-5175-924X;
FU PHS HHS [7-04M21]
NR 29
TC 20
Z9 20
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JUN
PY 2011
VL 53
IS 6
SU S
BP S68
EP S73
DI 10.1097/JOM.0b013e31821b1d3b
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 777LK
UT WOS:000291619100017
PM 21654421
ER
PT J
AU Kuempel, ED
AF Kuempel, Eileen D.
TI Carbon Nanotube Risk Assessment Implications for Exposure and Medical
Monitoring
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article; Proceedings Paper
CT Conference on Medical Surveillance, Exposure Registries, and
Epidemiologic Research
CY JUL 21-23, 2010
CL Keystone, CO
SP Natl Inst Occupation Safety & Hlth (NIOSH)
ID LUNG INFLAMMATION; INHALATION; RATS; MODEL
AB Objective: Quantitative risk estimates using toxicology data provide information for risk management to protect workers with potential exposure to carbon nanotubes (CNTs). Methods: Dose response data from subchronic inhalation studies in rats were used in benchmark dose modeling. Dose was airborne mass concentration of multiwalled CNTs. Responses included pulmonary inflammation, lipoproteinosis, and fibrosis. Results: Estimated human-equivalent concentrations to the rat lowest observed adverse effect levels were similar to some workplace airborne concentrations of CNTs. Working lifetime risk estimates of early-stage adverse lung effects were more than 10% at the limit of quantification (7 mu g/m(3)) of the National Institute for Occupational Safety and Health analytical method for measuring CNT airborne concentrations. Conclusions: Exposure monitoring and control are the primary occupational health measures to protect workers from potential exposure to CNT. Medical monitoring for early detection of occupational respiratory diseases may also be warranted.
C1 NIOSH, Educ & Informat Div, Cincinnati, OH 45226 USA.
RP Kuempel, ED (reprint author), NIOSH, Educ & Informat Div, 4676 Columbia Pkwy,MS C-15, Cincinnati, OH 45226 USA.
EM ekuempel@cdc.gov
NR 34
TC 9
Z9 9
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JUN
PY 2011
VL 53
IS 6
SU S
BP S91
EP S97
DI 10.1097/JOM.0b013e31821b1f3f
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 777LK
UT WOS:000291619100021
PM 21654426
ER
PT J
AU Laney, AS
McCauley, LA
Schubauer-Berigan, MK
AF Laney, A. Scott
McCauley, Linda A.
Schubauer-Berigan, Mary K.
TI Workshop Summary: Epidemiologic Design Strategies for Studies of
Nanomaterial Workers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article; Proceedings Paper
CT Conference on Medical Surveillance, Exposure Registries, and
Epidemiologic Research
CY JUL 21-23, 2010
CL Keystone, CO
SP Natl Inst Occupation Safety & Hlth (NIOSH)
ID PULMONARY-DISEASE; RAILROAD WORKERS
AB Objective: The potential health consequences of exposure to nanomaterials have yet to be elucidated though increasing evidence points to the potential for nanomaterials to cause adverse human health effects. This workshop addressed the feasibility of developing studies to measure health risks among nanomaterial workers. Methods: Breakout groups discussed different epidemiologic designs and methods to encourage companies to collect and retain exposure and health data. Results: Major challenges include defining and recruitment of appropriate study populations and obtaining adequate exposure data. Both prospective cohort studies and small cross-sectional panel studies utilizing biomarkers of exposure and effect offer approaches to study occupational groups. Conclusions: Potential exists to assemble cohorts to study the human health effects associated with nanomaterial exposure. Stakeholder partnerships are critical to the success of these studies and international partnerships hold great potential.
C1 [McCauley, Linda A.] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
[Laney, A. Scott; Schubauer-Berigan, Mary K.] NIOSH, Ctr Dis Control & Prevent, Atlanta, GA USA.
RP McCauley, LA (reprint author), Emory Univ, Sch Nursing, 1520 Clifton Rd,Ste 402, Atlanta, GA 30322 USA.
EM lmccaul@emory.edu
RI Schubauer-Berigan, Mary/B-3149-2009
OI Schubauer-Berigan, Mary/0000-0002-5175-924X
NR 8
TC 4
Z9 5
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JUN
PY 2011
VL 53
IS 6
SU S
BP S87
EP S90
DI 10.1097/JOM.0b013e31821b1af5
PG 4
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 777LK
UT WOS:000291619100020
PM 21654425
ER
PT J
AU Schubauer-Berigan, MK
Dahm, MM
Yencken, MS
AF Schubauer-Berigan, Mary K.
Dahm, Matthew M.
Yencken, Marianne S.
TI Engineered Carbonaceous Nanomaterials Manufacturers in the United States
Workforce Size, Characteristics, and Feasibility of Epidemiologic
Studies
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article; Proceedings Paper
CT Conference on Medical Surveillance, Exposure Registries, and
Epidemiologic Research
CY JUL 21-23, 2010
CL Keystone, CO
SP Natl Inst Occupation Safety & Hlth (NIOSH)
ID EXPOSURE; NANOTUBES; IDENTIFICATION; TOXICITY; LUNG; MICE
AB Objective: Toxicology studies suggest that carbon nanotube (CNT) exposures may cause adverse pulmonary effects. This study identified all US engineered carbonaceous nanomaterial (ECN) manufacturers, determined workforce size and growth, and characterized the materials produced to determine the feasibility of occupational ECN exposure studies. Methods: Eligible companies were identified; information was assembled on the companies and nanomaterials they produced; and the workforce size, location, and growth were estimated. Results: Sixty-one companies manufacturing ECN in the United States were identified. These companies employed at least 620 workers; workforce growth was projected at 15% to 17% annually. Most companies produced or used CNT. Half the eligible companies provided information about material dimensions, quantities, synthesis methods, and worker exposure reduction strategies. Conclusions: Industrywide exposure assessment studies appear feasible; however, cohort studies are likely infeasible because of the small, scattered workforce.
C1 [Schubauer-Berigan, Mary K.; Dahm, Matthew M.] NIOSH, Div Surveillance, Industrywide Studies Branch, Cincinnati, OH 45226 USA.
[Yencken, Marianne S.] Battelle Ctr Publ Hlth Res & Evaluat, Seattle, WA USA.
RP Schubauer-Berigan, MK (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Industrywide Studies Branch, 4676 Columbia Pkwy,MS-R15, Cincinnati, OH 45226 USA.
EM zcg3@cdc.gov
RI Schubauer-Berigan, Mary/B-3149-2009; Dahm, Matthew/I-2131-2012
OI Schubauer-Berigan, Mary/0000-0002-5175-924X;
FU PHS HHS [97-04M21]
NR 32
TC 21
Z9 21
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JUN
PY 2011
VL 53
IS 6
SU S
BP S62
EP S67
DI 10.1097/JOM.0b013e31821b1e2c
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 777LK
UT WOS:000291619100016
PM 21654420
ER
PT J
AU Schulte, PA
Trout, DB
Hodson, LL
AF Schulte, Paul A.
Trout, Douglas B.
Hodson, Laura L.
TI Introduction to the JOEM Supplement Nanomaterials and Worker Health
Medical Surveillance, Exposure Registries, and Epidemiologic Research
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Editorial Material
C1 [Schulte, Paul A.; Trout, Douglas B.; Hodson, Laura L.] NIOSH, Nanotechnol Res Ctr, Cincinnati, OH 45226 USA.
RP Schulte, PA (reprint author), NIOSH, Nanotechnol Res Ctr, Cincinnati, OH 45226 USA.
RI Hodson, Laura/F-4585-2011
NR 0
TC 1
Z9 1
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JUN
PY 2011
VL 53
IS 6
SU S
BP S1
EP S2
DI 10.1097/JOM.0b013e31821aec09
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 777LK
UT WOS:000291619100001
PM 21654408
ER
PT J
AU Schulte, PA
Mundt, DJ
Nasterlack, M
Mulloy, KB
Mundt, KA
AF Schulte, Paul A.
Mundt, Diane J.
Nasterlack, Michael
Mulloy, Karen B.
Mundt, Kenneth A.
TI Exposure Registries Overview and Utility for Nanomaterial Workers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article; Proceedings Paper
CT Conference on Medical Surveillance, Exposure Registries, and
Epidemiologic Research
CY JUL 21-23, 2010
CL Keystone, CO
SP Natl Inst Occupation Safety & Hlth (NIOSH)
ID RADIATION-DOSE-REGISTRY; MEDICAL SURVEILLANCE; BLADDER-CANCER;
HIGH-RISK; HEALTH REGISTRY; NOTIFICATION; NANOPARTICLES; MANAGEMENT
AB Objective: This article provides the background for consideration of exposure registries to address potential disease risks in nanomaterial workers. Methods: The history of exposure registries is reviewed with a focus on their purpose and criteria for establishment. Results: A rationale is presented for developing registries of nanomaterial workers, and unresolved obstacles and challenges are identified. These include issues on inclusion criteria, funding, potential for legal risks, access to data, confidentiality of business information, privacy, and workers' expectations. Conclusion: If society is to gain the benefits from nanotechnology, it must take precautions and demonstrate care for those, such as workers, who may be most at risk of adverse effects. Establishing exposure registries is a part of such a precautionary and caring approach.
C1 [Schulte, Paul A.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA.
[Mundt, Diane J.; Mundt, Kenneth A.] ENVIRON Int Corp, Boston, MA USA.
[Mundt, Diane J.; Mundt, Kenneth A.] ENVIRON Int Corp, Amherst, MA USA.
[Nasterlack, Michael] BASF SE, Ludwigshafen, Germany.
[Mulloy, Karen B.] Colorado Sch Publ Hlth, Mt & Plains Educ & Res Ctr, Aurora, CO USA.
RP Schulte, PA (reprint author), NIOSH, Ctr Dis Control & Prevent, 4676 Columbia Pkwy,MS C-14, Cincinnati, OH 45226 USA.
EM PSchulte@cdc.gov
NR 38
TC 10
Z9 10
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JUN
PY 2011
VL 53
IS 6
SU S
BP S42
EP S47
DI 10.1097/JOM.0b013e31821aebed
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 777LK
UT WOS:000291619100012
PM 21654416
ER
PT J
AU Schulte, PA
Trout, DB
AF Schulte, Paul A.
Trout, Douglas B.
TI Nanomaterials and Worker Health Medical Surveillance, Exposure
Registries, and Epidemiologic Research
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article; Proceedings Paper
CT Conference on Medical Surveillance, Exposure Registries, and
Epidemiologic Research
CY JUL 21-23, 2010
CL Keystone, CO
SP Natl Inst Occupation Safety & Hlth (NIOSH)
ID ENGINEERED NANOMATERIALS; CARBON-NANOTUBES; HAZARD SURVEILLANCE;
INHALATION EXPOSURE; DIESEL EXHAUST; NANOPARTICLES; WORKPLACE; STATE;
RATS
AB Objective: This article provides an overview of the issues that arise with medical surveillance, exposure registration, and epidemiologic research involving nanomaterial workers. Methods: An occupational health perspective is applied to detecting risks in nanomaterial workers individually and as a group. Results: General principles for medical surveillance, exposure registration, and epidemiologic research are identified. A model Nanomaterial Worker Health Study is for consideration. Conclusions: The Nanomaterial Worker Health Study can be developed as a tangible action in assuring the public that steps are being taken to learn of any adverse effects from exposure to nanomaterials.
C1 [Schulte, Paul A.; Trout, Douglas B.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA.
RP Schulte, PA (reprint author), NIOSH, Ctr Dis Control & Prevent, 4676 Columbia Pkwy,MS C-14, Cincinnati, OH 45226 USA.
EM PSchulte@cdc.gov
NR 44
TC 15
Z9 15
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JUN
PY 2011
VL 53
IS 6
SU S
BP S3
EP S7
DI 10.1097/JOM.0b013e31821b1b28
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 777LK
UT WOS:000291619100002
PM 21654413
ER
PT J
AU Trout, DB
AF Trout, Douglas B.
TI General Principles of Medical Surveillance Implications for Workers
Potentially Exposed to Nanomaterials
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article; Proceedings Paper
CT Conference on Medical Surveillance, Exposure Registries, and
Epidemiologic Research
CY JUL 21-23, 2010
CL Keystone, CO
SP Natl Inst Occupation Safety & Hlth (NIOSH)
AB Objective: As potential occupational exposure to nanomaterials becomes more prevalent, it is important that the principles of medical surveillance be considered for workers in the nanotechnology industry. Methods: The principles of medical surveillance are reviewed to further the discussion of occupational health surveillance for workers exposed to nanomaterials. Results: Because of the rapid evolution of nanotechnology, information may not be available to make a well-informed determination of all factors needed to evaluate risk of health effects from occupational exposure to nanomaterials. Conclusion: Every workplace dealing with engineered nanomaterials should conduct hazard and exposure assessments as part of an overall surveillance needs assessment for nanotechnology workers. In workplaces where risk is felt to be present, or at least cannot be ruled out, initiation of medical surveillance is prudent to protect workers' health.
C1 NIOSH, DSHEFS, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA.
RP Trout, DB (reprint author), NIOSH, DSHEFS, Ctr Dis Control & Prevent, R-12,4676 Columbia Pkwy, Cincinnati, OH 45226 USA.
EM dtrout@cdc.gov
FU Intramural CDC HHS [CC999999]
NR 10
TC 2
Z9 2
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JUN
PY 2011
VL 53
IS 6
SU S
BP S22
EP S24
DI 10.1097/JOM.0b013e31821b1e45
PG 3
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 777LK
UT WOS:000291619100006
PM 21606848
ER
PT J
AU Rasberry, CN
Lee, SM
Robin, L
Laris, BA
Russell, LA
Coyle, KK
Nihiser, AJ
AF Rasberry, Catherine N.
Lee, Sarah M.
Robin, Leah
Laris, B. A.
Russell, Lisa A.
Coyle, Karin K.
Nihiser, Allison J.
TI The association between school-based physical activity, including
physical education, and academic performance: A systematic review of the
literature
SO PREVENTIVE MEDICINE
LA English
DT Review
DE Physical activity; Physical education; Recess; Academic achievement
ID EXTRACURRICULAR ACTIVITIES; CLASSROOM-BEHAVIOR; ADOLESCENT ADJUSTMENT;
AFRICAN-AMERICAN; MOTOR-SKILLS; CHILDREN; PARTICIPATION; ACHIEVEMENT;
EXERCISE; STUDENTS
AB Objective. The purpose of this review is to synthesize the scientific literature that has examined the association between school-based physical activity (including physical education) and academic performance (including indicators of cognitive skills and attitudes, academic behaviors, and academic achievement).
Method. Relevant research was identified through a search of nine electronic databases using both physical activity and academic-related search terms. Forty-three articles (reporting a total of 50 unique studies) met the inclusion criteria and were read, abstracted, and coded for this synthesis. Findings of the 50 studies were then summarized.
Results. Across all the studies, there were a total of 251 associations between physical activity and academic performance, representing measures of academic achievement, academic behavior, and cognitive skills and attitudes. Slightly more than half (50.5%) of all associations examined were positive, 48% were not significant, and 1.5% were negative. Examination of the findings by each physical activity context provides insights regarding specific relationships.
Conclusion. Results suggest physical activity is either positively related to academic performance or that there is not a demonstrated relationship between physical activity and academic performance. Results have important implications for both policy and schools. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Rasberry, Catherine N.; Lee, Sarah M.; Robin, Leah; Nihiser, Allison J.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
[Laris, B. A.; Russell, Lisa A.; Coyle, Karin K.] ETR Associates, Scotts Valley, CA 95066 USA.
RP Rasberry, CN (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,NE MS K-33, Atlanta, GA 30341 USA.
EM CRasberry@cdc.gov
RI Nihiser, Allison/B-8662-2014; Rasberry, Catherine/P-1984-2016
OI Rasberry, Catherine/0000-0001-8256-6961
FU Centers for Disease Control and Prevention's (CDC) Division of
Adolescent and School Health (DASH) [200-2002-00800]; ETR Associates
FX This review was conducted, in part, for the Centers for Disease Control
and Prevention's (CDC) Division of Adolescent and School Health (DASH)
under contract #200-2002-00800 with ETR Associates.
NR 67
TC 98
Z9 100
U1 17
U2 100
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
J9 PREV MED
JI Prev. Med.
PD JUN 1
PY 2011
VL 52
SU 1
BP S10
EP S20
DI 10.1016/j.ypmed.2011.01.027
PG 11
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 779DS
UT WOS:000291758900003
PM 21291905
ER
PT J
AU Gibney, KB
Robinson, S
Mutebi, JP
Hoenig, DE
Bernier, BJ
Webber, L
Lubelczyk, C
Nett, RJ
Fischer, M
AF Gibney, Katherine B.
Robinson, Sara
Mutebi, John-Paul
Hoenig, Donald E.
Bernier, Brian J.
Webber, Lori
Lubelczyk, Charles
Nett, Randall J.
Fischer, Marc
TI Eastern Equine Encephalitis: An Emerging Arboviral Disease Threat,
Maine, 2009
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE eastern equine encephalitis; encephalitis; maine; meningitis
ID OUTBREAK
AB Background: Eastern equine encephalitis (EEE) is one of the most severe arboviral encephalitides in North America. Before 2009, limited nonhuman EEE virus activity had been reported in Maine, all from the southernmost area of the state. No human case has been reported in a Maine resident.
Methods: We review all EEE virus activity reported to Maine Centers for Disease Control in 2009 and describe current testing practices for possible human EEE cases.
Results: In 2009, fatal cases of EEE were identified in 15 horses, 1 llama, and 3 flocks of pheasants in Maine, with activity extending into the central part of the state. Although no human EEE cases were identified, diagnostic testing practices of most meningitis and encephalitis cases were inadequate to exclude EEE.
Conclusions: Work to better define the expanding range of EEE virus in Maine is warranted, along with education of healthcare providers regarding appropriate testing for this serious disease.
C1 [Gibney, Katherine B.; Mutebi, John-Paul; Nett, Randall J.; Fischer, Marc] Ctr Dis Control & Prevent, Div Vector Borne Dis, Arboviral Dis Branch, Ft Collins, CO 80521 USA.
[Gibney, Katherine B.] Ctr Dis Control & Prevent, Epidem Intelligence Serv Off, Atlanta, GA USA.
[Robinson, Sara] Maine Ctr Dis Control & Prevent, Infect Dis Epidemiol Program, Augusta, ME USA.
[Hoenig, Donald E.] Maine Dept Agr Food & Rural Resources, Div Anim Hlth & Ind, Augusta, ME USA.
[Bernier, Brian J.; Webber, Lori] Maine Ctr Dis Control & Prevent, Hlth & Environm Testing Lab, Augusta, ME USA.
[Lubelczyk, Charles] Maine Med Ctr, Res Inst, Vector Borne Dis Lab, Portland, ME 04102 USA.
RP Fischer, M (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Arboviral Dis Branch, 3150 Rampart Rd, Ft Collins, CO 80521 USA.
EM mfischer@cdc.gov
OI Gibney, Katherine/0000-0001-5851-5339
NR 10
TC 11
Z9 13
U1 0
U2 7
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD JUN
PY 2011
VL 11
IS 6
BP 637
EP 639
DI 10.1089/vbz.2010.0189
PG 3
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 778PV
UT WOS:000291717500008
PM 21254938
ER
PT J
AU Brault, AC
Kinney, RM
Maharaj, PD
Green, ENG
Reisen, WK
Huang, CYH
AF Brault, Aaron C.
Kinney, Richard M.
Maharaj, Payal D.
Green, Emily N. G.
Reisen, William K.
Huang, Claire Y-H
TI Replication of the Primary Dog Kidney-53 Dengue 2 Virus Vaccine
Candidate in Aedes aegypti Is Modulated by a Mutation in the 5 '
Untranslated Region and Amino Acid Substitutions in Nonstructural
Proteins 1 and 3
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Aedes aegypti; Dengue; Mosquito; PDK-53; Vaccine
ID WEST-NILE-VIRUS; YELLOW-FEVER VIRUS; STRAIN 16681; ENVELOPE
GLYCOPROTEIN; VIRAL DISSEMINATION; ATTENUATION MARKERS;
ENCEPHALITIS-VIRUS; VECTOR COMPETENCE; MOSQUITO VECTORS; ORAL INFECTION
AB Previous studies have demonstrated reduced replication of the cell culture-adapted Dengue-2 virus (DENV-2) vaccine candidate, primary dog kidney (PDK)-53, compared with the parental DENV-2 strain, 16681, in C6/36 cells. Various DENV-2 mutants incorporating PDK-53 substitutions singly and in combination into the 16681 genetic backbone were used to identify the genetic basis for impaired replication of the vaccine candidate in vitro in Aedes aegypti cell culture (Aag2 cells) as well as the reduced in vivo infectivity and transmissibility within Ae. aegypti infected by intrathoracic inoculation. 50 untranslated region (UTR-c57t) and nonstructural protein 1 (NS1-G53D) mutations were required to completely attenuate in vitro replication. In contrast, incorporation of the PDK-53-specific NS3-250V mutation into the 16681 virus resulted in reduced replication in mosquitoes but had no effect on in vitro replication. Further, reversion of the PDK-53 NS3-250 site to that of the wild-type 16681 virus (NS3-V250E) failed to increase either in vitro or in vivo replication. Intrathoracic inoculation of Ae. aegypti with mutants containing the PDK-53 NS1 substitution exhibited in vivo replication indistinguishable from the parental PDK-53 virus, implicating this mutation as the dominant determinant for impaired mosquito replication of the PDK-53 candidate; however, further attenuation of in vivo replication was magnified in mutants including the additional 5'UTR-c57t mutation.
C1 [Brault, Aaron C.; Kinney, Richard M.; Maharaj, Payal D.; Huang, Claire Y-H] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, US Dept HHS, Ft Collins, CO 80521 USA.
[Brault, Aaron C.; Maharaj, Payal D.; Green, Emily N. G.; Reisen, William K.] Univ Calif Davis, Sch Vet Med, Ctr Vector Borne Dis, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA.
RP Brault, AC (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, US Dept HHS, Foothills Campus,Rampart Rd, Ft Collins, CO 80521 USA.
EM abrault@cdc.gov
OI Maharaj, Payal/0000-0002-4157-4479
FU Centers for Disease Control and Prevention
FX This work was partially funded by a research contract to the University
of California, Davis from the Centers for Disease Control and
Prevention. Claire Huang and Richard Kinney are among the inventors, and
recipients of an awarded patent, of candidate live-attenuated, chimeric
dengue vaccine viruses that are based on the attenuated genetic
background of the DENV-2 PDK-53 strain. CDC has licensed these candidate
vaccine viruses to Inviragen Inc. for commercial manufacture and
clinical trial.
NR 39
TC 9
Z9 9
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD JUN
PY 2011
VL 11
IS 6
BP 683
EP 689
DI 10.1089/vbz.2010.0150
PG 7
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 778PV
UT WOS:000291717500014
PM 21284523
ER
PT J
AU Lampe, MA
Smith, DK
Anderson, GJE
Edwards, AE
Nesheim, SR
AF Lampe, Margaret A.
Smith, Dawn K.
Anderson, Gillian J. E.
Edwards, Ashley E.
Nesheim, Steven R.
TI Achieving safe conception in HIV-discordant couples: the potential role
of oral preexposure prophylaxis (PrEP) in the United States
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE conception; discordant couples; human immunodeficiency virus;
preexposure prophylaxis; pregnancy
ID HUMAN-IMMUNODEFICIENCY-VIRUS; TO-CHILD TRANSMISSION; TENOFOVIR
DISOPROXIL FUMARATE; HIV-1-SERODISCORDANT COUPLES; ANTIRETROVIRAL
THERAPY; INFERTILITY SERVICES; SEXUAL TRANSMISSION; DRUG-RESISTANCE;
RHESUS MACAQUES; GENITAL-TRACT
AB Approximately half of HIV-discordant heterosexual couples in the United States want children. Oral antiretroviral preexposure prophylaxis, if effective in reducing heterosexual HIV transmission, might be an option for discordant couples wanting to conceive. Couples should receive services to ensure they enter pregnancy in optimal health and receive education about all conception methods that reduce the risk of HIV transmission. In considering whether preexposure prophylaxis is indicated, the question is whether it contributes to lowering risk in couples who have decided to conceive despite known risks. If preexposure prophylaxis is used, precautions similar to those in the current heterosexual preexposure prophylaxis trials would be recommended, and the unknown risks of preexposure prophylaxis used during conception and early fetal development should be considered. Anecdotal reports suggest that oral preexposure prophylaxis use is already occurring. It is time to have open discussions of when and how preexposure prophylaxis might be indicated for HIV-discordant couples attempting conception.
C1 [Lampe, Margaret A.; Smith, Dawn K.; Anderson, Gillian J. E.; Edwards, Ashley E.; Nesheim, Steven R.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA.
RP Lampe, MA (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA.
NR 55
TC 2
Z9 2
U1 2
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUN
PY 2011
VL 204
IS 6
AR 488.e1
DI 10.1016/j.ajog.2011.02.026
PG 8
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 775QL
UT WOS:000291477300019
PM 21457911
ER
PT J
AU Kreuter, JD
Barnes, A
McCarthy, JE
Schwartzman, JD
Oberste, MS
Rhodes, CH
Modlin, JF
Wright, PF
AF Kreuter, Justin D.
Barnes, Arti
McCarthy, James E.
Schwartzman, Joseph D.
Oberste, M. Steven
Rhodes, C. Harker
Modlin, John F.
Wright, Peter F.
TI A Fatal Central Nervous System Enterovirus 68 Infection
SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
LA English
DT Article
ID COMPLICATIONS; FEATURES; CHILDREN; DISEASE; TAIWAN
AB The anticipated eradication of poliovirus emphasizes the need to identify other enteroviral causes of severe central nervous system disease. Enterovirus 68 has been implicated only in cases of respiratory illness. We therefore report a case of fatal meningomyeloencephalitis caused by enterovirus 68 in a 5-year-old boy, which required neuropathology, microbiology, and molecular techniques to diagnose. (Arch Pathol Lab Med. 2011;135:793-796)
C1 [Kreuter, Justin D.; Schwartzman, Joseph D.; Rhodes, C. Harker] Dartmouth Hitchcock Med Ctr, Dept Pathol, Lebanon, NH 03756 USA.
[Barnes, Arti] Dartmouth Hitchcock Med Ctr, Dept Med, Lebanon, NH 03756 USA.
[McCarthy, James E.; Modlin, John F.; Wright, Peter F.] Dartmouth Hitchcock Med Ctr, Dept Pediat, Lebanon, NH 03756 USA.
[Oberste, M. Steven] Ctr Dis Control & Prevent, Dept Virol, Atlanta, GA USA.
RP Kreuter, JD (reprint author), Dartmouth Hitchcock Med Ctr, Dept Pathol, 1 Med Ctr Dr, Lebanon, NH 03756 USA.
EM justin.d.kreuter@hitchcock.org
NR 15
TC 70
Z9 74
U1 0
U2 6
PU COLLEGE AMER PATHOLOGISTS
PI NORTHFIELD
PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA
SN 0003-9985
J9 ARCH PATHOL LAB MED
JI Arch. Pathol. Lab. Med.
PD JUN
PY 2011
VL 135
IS 6
BP 793
EP 796
PG 4
WC Medical Laboratory Technology; Medicine, Research & Experimental;
Pathology
SC Medical Laboratory Technology; Research & Experimental Medicine;
Pathology
GA 774QA
UT WOS:000291400000020
PM 21631275
ER
PT J
AU Bush, KF
Luber, G
Kotha, SR
Dhaliwal, RS
Kapil, V
Pascual, M
Brown, DG
Frumkin, H
Dhiman, RC
Hess, J
Wilson, ML
Balakrishnan, K
Eisenberg, J
Kaur, T
Rood, R
Batterman, S
Joseph, A
Gronlund, CJ
Agrawal, A
Hu, H
AF Bush, Kathleen F.
Luber, George
Kotha, S. Rani
Dhaliwal, R. S.
Kapil, Vikas
Pascual, Mercedes
Brown, Daniel G.
Frumkin, Howard
Dhiman, R. C.
Hess, Jeremy
Wilson, Mark L.
Balakrishnan, Kalpana
Eisenberg, Joseph
Kaur, Tanvir
Rood, Richard
Batterman, Stuart
Joseph, Aley
Gronlund, Carina J.
Agrawal, Arun
Hu, Howard
TI Impacts of Climate Change on Public Health in India: Future Research
Directions
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
DE air pollution; climate change; climate variability; health; heat; India;
vector-borne; waterborne
ID GLOBAL HEALTH; MALARIA RISK; BURDEN; VULNERABILITY; TEMPERATURE;
POLLUTION; MORTALITY; DISEASES; DELHI; HEAT
AB BACKGROUND: Climate change and associated increases in climate variability will likely further exacerbate global health disparities. More research is needed, particularly in developing countries, to accurately predict the anticipated impacts and inform effective interventions.
OBJECTIVES: Building on the information presented at the 2009 Joint Indo-U.S. Workshop on Climate Change and Health in Goa, India, we reviewed relevant literature and data, addressed gaps in knowledge, and identified priorities and strategies for future research in India.
DISCUSSION: The scope of the problem in India is enormous, based on the potential for climate change and variability to exacerbate endemic malaria, dengue, yellow fever, cholera, and chikungunya, as well as chronic diseases, particularly among the millions of people who already experience poor sanitation, pollution, malnutrition, and a shortage of drinking water. Ongoing efforts to study these risks were discussed but remain scant. A universal theme of the recommendations developed was the importance of improving the surveillance, monitoring, and integration of meteorological, environmental, geo-spatial, and health data while working in parallel to implement adaptation strategies.
CONCLUSIONS: It will be critical for India to invest in improvements in information infrastructure that are innovative and that promote interdisciplinary collaborations while embarking on adaptation strategies. This will require unprecedented levels of collaboration across diverse institutions in India and abroad. The data can be used in research on the likely impacts of climate change on health that reflect India's diverse climates and populations. Local human and technical capacities for risk communication and promoting adaptive behavior must also be enhanced.
C1 [Bush, Kathleen F.; Eisenberg, Joseph; Batterman, Stuart; Gronlund, Carina J.; Hu, Howard] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
[Luber, George; Kapil, Vikas; Hess, Jeremy] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Kotha, S. Rani] Univ Michigan, Ctr Global Hlth, Ann Arbor, MI 48109 USA.
[Dhaliwal, R. S.; Kaur, Tanvir] Indian Council Med Res, New Delhi, India.
[Pascual, Mercedes; Wilson, Mark L.] Univ Michigan, Dept Evolutionary & Ecol Biol, Ann Arbor, MI 48109 USA.
[Pascual, Mercedes] Howard Hughes Med Inst, Chevy Chase, MD USA.
[Brown, Daniel G.; Agrawal, Arun] Univ Michigan, Sch Nat Resources & Environm, Ann Arbor, MI 48109 USA.
[Frumkin, Howard] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA.
[Dhiman, R. C.] Natl Inst Malaria Res, New Delhi, India.
[Wilson, Mark L.; Eisenberg, Joseph; Joseph, Aley] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
[Balakrishnan, Kalpana] Sri Ramachandra Univ, Dept Environm Hlth & Engn, Chennai, Tamil Nadu, India.
[Rood, Richard] Univ Michigan, Dept Atmospher Ocean & Space Sci, Ann Arbor, MI 48109 USA.
RP Bush, KF (reprint author), Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 6th Floor,SPH Tower,1415 Washington Hts, Ann Arbor, MI 48109 USA.
EM kfbush@umich.edu
RI Brown, Daniel/L-8089-2013; Rood, Richard/C-5611-2008; Agrawal,
Arun/A-4257-2009; Balakrishnan, Kalpana/B-6653-2015
OI Hu, Howard/0000-0002-3676-2707; Brown, Daniel/0000-0001-6023-5950; Rood,
Richard/0000-0002-2310-4262; Agrawal, Arun/0000-0001-6796-2958; Frumkin,
Howard/0000-0001-7079-3534; Batterman, Stuart/0000-0001-9894-5325;
Balakrishnan, Kalpana/0000-0002-5905-1801
FU University of Michigan
FX This work is based on the 2009 workshop in Goa, India, which was
principally supported by the University of Michigan Center for Global
Health, the U. S. Centers for Disease Control and Prevention, and the
Indian Council for Medical Research. K. F. B. was supported by a
University of Michigan Graham Environmental Sustainability Institute
doctoral fellowship.
NR 54
TC 18
Z9 18
U1 4
U2 67
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JUN
PY 2011
VL 119
IS 6
BP 765
EP 770
DI 10.1289/ehp.1003000
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 771JC
UT WOS:000291152000018
PM 21273162
ER
PT J
AU Berg, JS
Khoury, MJ
Evans, JP
AF Berg, Jonathan S.
Khoury, Muin J.
Evans, James P.
TI Deploying whole genome sequencing in clinical practice and public
health: Meeting the challenge one bin at a time
SO GENETICS IN MEDICINE
LA English
DT Editorial Material
ID EGAPP WORKING GROUP; LYNCH-SYNDROME; COLORECTAL-CANCER; WIDE
ASSOCIATION; MEDICINE; RISK; RECOMMENDATIONS; INFORMATION; DISEASES
C1 [Berg, Jonathan S.; Evans, James P.] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA.
[Khoury, Muin J.] CDC, Off Publ Hlth Genom, Atlanta, GA 30333 USA.
RP Berg, JS (reprint author), Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA.
EM JSBerg@med.unc.edu
NR 35
TC 233
Z9 235
U1 3
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1098-3600
J9 GENET MED
JI Genet. Med.
PD JUN
PY 2011
VL 13
IS 6
BP 499
EP 504
DI 10.1097/GIM.0b013e318220aaba
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 774ZX
UT WOS:000291426800002
PM 21558861
ER
PT J
AU Kennedy, A
LaVail, K
Nowak, G
Basket, M
Landry, S
AF Kennedy, Allison
LaVail, Katherine
Nowak, Glen
Basket, Michelle
Landry, Sarah
TI Confidence About Vaccines In The United States: Understanding Parents'
Perceptions
SO HEALTH AFFAIRS
LA English
DT Article
ID HEALTH INFORMATION; PREVENTABLE DISEASES; VACCINATION COVERAGE;
IMMUNIZATION; CARE; SYSTEM; COMMUNICATION; CONTROVERSIES; QUALITY;
SAFETY
AB The United States has made tremendous progress in using vaccines to prevent serious, often infectious, diseases. But concerns about such issues as vaccines' safety and the increasing complexity of immunization schedules have fostered doubts about the necessity of vaccinations. We investigated parents' confidence in childhood vaccines by reviewing recent survey data. We found that most parents-even those whose children receive all of the recommended vaccines-have questions, concerns, or misperceptions about them. We suggest ways to give parents the information they need and to keep the US national vaccination program a success.
C1 [Kennedy, Allison] Ctr Dis Control & Prevent CDC, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[LaVail, Katherine] Carter Consulting Inc, Hlth Commun Sci Off, Natl Ctr Immunizat & Resp Dis, CDC, Atlanta, GA USA.
[Landry, Sarah] Natl Vaccine Program Off, Dept Hlth & Human Serv, Washington, DC USA.
RP Kennedy, A (reprint author), Ctr Dis Control & Prevent CDC, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
EM akennedy@cdc.gov
NR 40
TC 74
Z9 75
U1 3
U2 28
PU PROJECT HOPE
PI BETHESDA
PA 7500 OLD GEORGETOWN RD, STE 600, BETHESDA, MD 20814-6133 USA
SN 0278-2715
J9 HEALTH AFFAIR
JI Health Aff.
PD JUN
PY 2011
VL 30
IS 6
BP 1151
EP 1159
DI 10.1377/hlthaff.2011.0396
PG 9
WC Health Care Sciences & Services; Health Policy & Services
SC Health Care Sciences & Services
GA 775CT
UT WOS:000291436100021
PM 21653969
ER
PT J
AU Ryan, LJ
Ferrieri, P
Powell, RD
Paddock, CD
Zaki, SR
Pambuccian, SE
AF Ryan, Lori J.
Ferrieri, Patricia
Powell, Ralph D., Jr.
Paddock, Christopher D.
Zaki, Sherif R.
Pambuccian, Stefan E.
TI Fatal Cokeromyces recurvatus Pneumonia: Report of a Case Highlighting
the Potential for Histopathologic Misdiagnosis as Coccidioides
SO INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
LA English
DT Article
DE Cokeromyces recurvatus pneumonia; Coccidioides immitis
ID MARROW TRANSPLANT RECIPIENT; PERITONEAL-FLUID; IDENTIFICATION;
ZYGOMYCOSIS; FUNGI
AB Cokeromyces recurvatus is a dimorphic zygomycete with histologic morphology similar to Coccidioides immitis. A 66-year-old man who was status-post bone marrow transplantation for chronic myelogenous leukemia was hospitalized with new onset rash, nausea, and vomiting and subsequently expired. A sputum culture collected on the day of death revealed heavy growth of C. recurvatus 6 days after collection. At autopsy, microscopic examination of the lungs revealed numerous thick-walled, nonbudding spherules ranging in size from 40 to 80 mu m. Initial immunohistochemical staining of the formalin-fixed lung tissue was positive for Coccidioides. Additional immunoperoxidase staining revealed the organisms were consistent with a zygomycete fungus, compatible with C. recurvatus infection. Polymerase chain reaction using panfungal primers was attempted on the formalin-fixed tissue but was inconclusive. This case highlights the potential for misdiagnosing Cokeromyces as Coccidioides when the diagnosis is based on histology and immunohistochemical staining.
C1 [Pambuccian, Stefan E.] Univ Minnesota, Dept Lab Med & Pathol, Div Cytopathol, Minneapolis, MN 55455 USA.
[Paddock, Christopher D.; Zaki, Sherif R.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Pambuccian, SE (reprint author), Univ Minnesota, Dept Lab Med & Pathol, Div Cytopathol, 420 Delaware SE,C422 Mayo,MMC 76, Minneapolis, MN 55455 USA.
EM pambu001@umn.edu
NR 17
TC 6
Z9 6
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1066-8969
J9 INT J SURG PATHOL
JI Int. J. Surg. Pathol.
PD JUN
PY 2011
VL 19
IS 3
BP 373
EP 376
DI 10.1177/1066896908330483
PG 4
WC Pathology; Surgery
SC Pathology; Surgery
GA 776TD
UT WOS:000291560000018
PM 19147507
ER
PT J
AU Jackson, KA
Biggerstaff, M
Tobin-D'Angelo, M
Sweat, D
Klos, R
Nosari, J
Garrison, O
Boothe, E
Saathoff-Huber, L
Hainstock, L
Fagan, RP
AF Jackson, K. A.
Biggerstaff, M.
Tobin-D'Angelo, M.
Sweat, D.
Klos, R.
Nosari, J.
Garrison, O.
Boothe, E.
Saathoff-Huber, L.
Hainstock, L.
Fagan, R. P.
TI Multistate Outbreak of Listeria monocytogenes Associated with
Mexican-Style Cheese Made from Pasteurized Milk among Pregnant, Hispanic
Women
SO JOURNAL OF FOOD PROTECTION
LA English
DT Article
ID UNITED-STATES; ILLNESS
AB Listeriosis is a severe infection caused by Listeria monocytogenes. Since 2004, the Centers for Disease Control and Prevention has requested that listeriosis patients be interviewed using a standardized Listeria Initiative (LI) questionnaire. In January 2009, states and the Centers for Disease Control and Prevention began investigating a multistate outbreak of listeriosis among pregnant, Hispanic women. We defined a case as an illness occurring between October 2008 and March 2009 with art L. monocytogenes isolate indistinguishable from the outbreak strain by pulsed-field gel electrophoresis. We conducted a multistate case-control study using controls that were selected from L. monocytogenes illnesses in non-outbreak-related pregnant, Hispanic women that were reported to the LI during 2004 to 2008. Eight cases in five states were identified. Seven of these were pregnant, Hispanic females aged 21 to 43 years, and one was a 3-year-old Hispanic girl, who was excluded from the study. Seven (100%) cases but only 26 (60%) of 43 controls had consumed Mexican-style cheese in the month before illness (odds ratio, 5.89; 95% confidence interval, 1.07 to infinity; P = 0.04). Cultures of asadero cheese made from pasteurized milk collected at a manufacturing facility during routine sampling by the Michigan Department of Agriculture on 23 February 2009 yielded the outbreak strain, leading to a recall of cheeses produced in the plant. Recalled product was traced to stores where at least three of the women had purchased cheese. This investigation highlights the usefulness of routine product sampling for identifying contaminated foods, of pulsed-field gel electrophoresis analysis to detect multistate outbreaks, and of the LI for providing timely exposure information for case-control analyses. Recalls of contaminated cheeses likely prevented additional illnesses.
C1 [Jackson, K. A.; Biggerstaff, M.; Fagan, R. P.] Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
[Tobin-D'Angelo, M.] Georgia Dept Community Hlth, Div Publ Hlth, Atlanta, GA 30303 USA.
[Sweat, D.] N Carolina Div Publ Health, Raleigh, NC 27699 USA.
[Klos, R.] Wisconsin Dept Hlth Serv, Madison, WI 53703 USA.
[Nosari, J.] Illinois Dept Publ Hlth, Div Food Drugs & Dairies, Springfield, IL 62761 USA.
[Garrison, O.] Georgia Dept Agr, Consumer Protect Div, Atlanta, GA 30334 USA.
[Boothe, E.] Tennessee Dept Hlth, Nashville, TN 37243 USA.
Illinois Dept Publ Hlth, Communicable Dis Control Sect, Springfield, IL 62761 USA.
[Hainstock, L.] Michigan Dept Agr, Lansing, MI 48909 USA.
RP Jackson, KA (reprint author), Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
EM gqv8@cdc.gov
NR 15
TC 48
Z9 48
U1 1
U2 11
PU INT ASSOC FOOD PROTECTION
PI DES MOINES
PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2863 USA
SN 0362-028X
J9 J FOOD PROTECT
JI J. Food Prot.
PD JUN
PY 2011
VL 74
IS 6
BP 949
EP 953
DI 10.4315/0362-028X.JFP-10-536
PG 5
WC Biotechnology & Applied Microbiology; Food Science & Technology
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 776HG
UT WOS:000291524500012
PM 21669072
ER
PT J
AU Gould, LH
Seys, S
Everstine, K
Norton, D
Ripley, D
Reimann, D
Dreyfuss, M
Chen, WS
Selman, CA
AF Gould, L. Hannah
Seys, Scott
Everstine, Karen
Norton, Dawn
Ripley, Danny
Reimann, David
Dreyfuss, Moshe
Chen, Wu San
Selman, Carol A.
TI Recordkeeping Practices of Beef Grinding Activities at Retail
Establishments
SO JOURNAL OF FOOD PROTECTION
LA English
DT Article
ID ESCHERICHIA-COLI; GROUND-BEEF
AB Ground beef has been implicated as a transmission vehicle in foodborne outbreaks of infection with pathogens such as Escherichia coli O157:H7 and Salmonella. During outbreak investigations, traceback of contaminated beef to the producing facility is often unsuccessful because of inadequate recordkeeping at retail establishments that grind beef products. We conducted a survey in three states participating in the Environmental Health Specialists Network to describe beef grinding and recordkeeping practices at retail establishments. In each establishment that maintained grinding logs, three randomly selected records were reviewed to determine whether important data elements for traceback investigations were recorded. One hundred twenty-five stores were surveyed, of which 60 (49%) kept grinding logs, including 54 (74%) of 73 chain stores and 6 (12%) of 51 independent stores. One hundred seventy-six grinding records from 61 stores were reviewed. Seventy-three percent of the records included the establishment code of the source beef, 72% included the grind date and time, and 59% included the lot number of the source beef. Seventy-five percent of records noted whether trimmings were included in grinds, and 57% documented cleanup activities. Only 39 (22%) records had all of these variables completed. Of stores that did not keep grinding logs, 40% were unaware of their purpose. To facilitate effective and efficient traceback investigations by regulatory agencies, retail establishments should maintain records more detailed and complete of all grinding activities.
C1 [Gould, L. Hannah] Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
[Seys, Scott] US Food Safety & Inspect Serv, Foodborne Dis Invest Branch, USDA, Washington, DC 20250 USA.
[Everstine, Karen; Reimann, David] Minnesota Dept Hlth, St Paul, MN 55101 USA.
[Norton, Dawn] Calif Emerging Infect Program, Oakland, CA 94612 USA.
[Ripley, Danny] Nashville Davidson Cty Metro Publ Hlth Dept, Nashville, TN 37201 USA.
[Dreyfuss, Moshe; Chen, Wu San] US Food Safety & Inspect Serv, Microbiol Issues Branch, USDA, Aerosp Ctr, Washington, DC 20250 USA.
[Selman, Carol A.] Ctr Dis Control & Prevent, Environm Hlth Serv Branch, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
RP Gould, LH (reprint author), Ctr Dis Control & Prevent, Enter Dis Epidemiol Branch, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd NE,MS D63, Atlanta, GA 30333 USA.
EM lgould@cdc.gov
NR 10
TC 3
Z9 3
U1 0
U2 2
PU INT ASSOC FOOD PROTECTION
PI DES MOINES
PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2863 USA
SN 0362-028X
EI 1944-9097
J9 J FOOD PROTECT
JI J. Food Prot.
PD JUN
PY 2011
VL 74
IS 6
BP 1022
EP 1024
DI 10.4315/0362-028X.JFP-10-370
PG 3
WC Biotechnology & Applied Microbiology; Food Science & Technology
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 776HG
UT WOS:000291524500025
PM 21669085
ER
PT J
AU Schoenfisch, AL
Dollard, SC
Amin, M
Gardner, LI
Klein, RS
Mayer, K
Rompalo, A
Sober, JD
Cannon, MJ
AF Schoenfisch, Ashley L.
Dollard, Sheila C.
Amin, Minal
Gardner, Lytt I.
Klein, Robert S.
Mayer, Kenneth
Rompalo, Anne
Sober, Jack D.
Cannon, Michael J.
TI Cytomegalovirus (CMV) shedding is highly correlated with markers of
immunosuppression in CMV-seropositive women
SO JOURNAL OF MEDICAL MICROBIOLOGY
LA English
DT Article
ID SEXUALLY-TRANSMITTED-DISEASES; NONPREGNANT WOMEN; PREGNANT-WOMEN;
HEARING-LOSS; PRIMARY INFECTION; VIRUS-INFECTION; RISK-FACTORS;
ASSOCIATION; PREVALENCE; EXCRETION
AB Cytomegalovirus (CMV) enters latency following primary infection and can subsequently reactivate. Reinfection with a different viral strain can also occur. During these events, CMV is shed in bodily fluids. This study examined correlates of CMV shedding in specimens obtained from the HIV Epidemiology Research Study, a multicenter cohort study of US women with or at high risk for human immunodeficiency virus (HIV) infection. Among the women studied, 91.4% (911/997) were CMV IgG seropositive. Of these women, 2.7% (25/911) were CMV IgM seropositive. CMV DNA was detected via real-time PCR more frequently in cervicovaginal lavage (CVL) specimens (55/764, 7.2%) than in peripheral blood mononuclear cells (PBMCs) (26/897, 2.9%). CMV viral loads in 1 ml CVL (median 534; mean 2598; range=40-74 844) were higher than in 106 PBMCs (median 264; mean 1287; range=35-13 250). CMV DNA in PBMCs was associated with HIV seropositivity [odds ratio (OR) 13.5; 95% confidence interval (Cl) 1.8-100], increasing HIV viral load (P<0.001 for trend), decreasing CD4 cell counts (P<0.001 for trend) and CMV DNA in CVL (OR 26; 95% Cl 10.7-64). CMV DNA in CVL specimens was associated with CMV IgM seropositivity (OR 4.3; 95% Cl 1.5-12.3), HIV seropositivity (OR 7.3; 95% Cl 2.6-20), increasing HIV viral load (P<0.001 for trend) and decreasing CD4 cell counts (P<0.001 for trend). The positive predictive value of CMV IgM seropositivity for CMV DNA shedding in either PBMCs or CVL was 20%. In summary, CMV shedding in CVL and PBMCs was highly correlated with each other and with markers of immune suppression.
C1 [Cannon, Michael J.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Schoenfisch, Ashley L.] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
[Dollard, Sheila C.; Amin, Minal] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Gardner, Lytt I.] Ctr Dis Control & Prevent, Natl Ctr HIV STD & TB Prevent, Atlanta, GA USA.
[Klein, Robert S.] Albert Einstein Coll Med, Monash Med Ctr, Bronx, NY 10467 USA.
[Mayer, Kenneth] Brown Univ, Sch Med, Providence, RI 02912 USA.
[Rompalo, Anne] Johns Hopkins Univ, Baltimore, MD USA.
[Sober, Jack D.] Wayne State Sch Med, Detroit, MI USA.
RP Cannon, MJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
EM mcannon@cdc.gov
RI Cannon, Michael/E-5894-2011
OI Cannon, Michael/0000-0001-5776-5010
NR 49
TC 14
Z9 14
U1 0
U2 0
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
BERKS, ENGLAND
SN 0022-2615
J9 J MED MICROBIOL
JI J. Med. Microbiol.
PD JUN
PY 2011
VL 60
IS 6
BP 768
EP 774
DI 10.1099/jmm.0.027771-0
PG 7
WC Microbiology
SC Microbiology
GA 774FJ
UT WOS:000291370200011
PM 21393456
ER
PT J
AU Gunawardana, M
Moss, JA
Smith, TJ
Kennedy, S
Kopin, E
Nguyen, C
Malone, AM
Rabe, L
Schaudinn, C
Webster, P
Srinivasan, P
Sweeney, ED
Smith, JM
Baum, MM
AF Gunawardana, Manjula
Moss, John A.
Smith, Thomas J.
Kennedy, Sean
Kopin, Etana
Cali Nguyen
Malone, Amanda M.
Rabe, Lorna
Schaudinn, Christoph
Webster, Paul
Srinivasan, Priya
Sweeney, Elizabeth D.
Smith, James M.
Baum, Marc M.
TI Microbial biofilms on the surface of intravaginal rings worn in
non-human primates
SO JOURNAL OF MEDICAL MICROBIOLOGY
LA English
DT Article
ID FLUORESCENTLY LABELED LECTINS; VAGINAL RING; BACTERIAL VAGINOSIS;
DELIVERY; MODEL; MICROORGANISMS; IDENTIFICATION; INFECTIONS; RESERVOIR;
THERAPY
AB Millions of intravaginal rings (IVRs) are used by women worldwide for contraception and for the treatment of vaginal atrophy. These devices also are suitable for local and systemic sustained release drug delivery, notably for antiviral agents in human immunodeficiency virus pre-exposure prophylaxis. Despite the widespread use of IVRs, no studies have examined whether surface-attached bacterial biofilms develop in vivo, an important consideration when determining the safety of these devices. The present study used scanning electron microscopy, fluorescence in situ hybridization and confocal laser scanning microscopy to study biofilms that formed on the surface of IVRs worn for 28 days by six female pig-tailed macaques, an excellent model organism for the human vaginal microbiome. Four of the IVRs released the nucleotide analogue reverse transcriptase inhibitor tenofovir at a controlled rate and the remaining two were unmedicated. Large areas of the ring surfaces were covered with monolayers of epithelial cells. Two bacterial biofilm phenotypes were found to develop on these monolayers and both had a broad diversity of bacterial cells closely associated with the extracellular material. Phenotype I, the more common of the two, consisted of tightly packed bacterial mats approximately 5 mu m in thickness. Phenotype II was much thicker, typically 40 mu m, and had an open architecture containing interwoven networks of uniform fibres. There was no significant difference in biofilm thickness and appearance between medicated and unmedicated IVRs. These preliminary results suggest that bacterial biofilms could be common on intravaginal devices worn for extended periods of time.
C1 [Gunawardana, Manjula; Moss, John A.; Smith, Thomas J.; Kennedy, Sean; Cali Nguyen; Baum, Marc M.] Oak Crest Inst Sci, Dept Chem, Pasadena, CA USA.
[Gunawardana, Manjula; Smith, Thomas J.; Kopin, Etana; Cali Nguyen; Malone, Amanda M.] Auritec Pharmaceut Inc, Santa Monica, CA USA.
[Smith, Thomas J.] Univ Kentucky, Dept Ophthalmol, Lexington, KY USA.
[Rabe, Lorna] Magee Womens Res Inst, Pittsburgh, PA USA.
[Schaudinn, Christoph; Webster, Paul] Ahmanson Adv & Imaging Ctr, Los Angeles, CA USA.
[Srinivasan, Priya; Sweeney, Elizabeth D.; Smith, James M.] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV,CCID, Atlanta, GA USA.
RP Baum, MM (reprint author), Oak Crest Inst Sci, Dept Chem, 2275 E Foothill Blvd, Pasadena, CA USA.
EM m.baum@oak-crest.org
FU National Institutes of Health [5R21AI079791, 5R21AI076136]; CONRAD
[PSA-08-10, PPC-09-017]; International Partnership for Microbicides; US
Agency for International Development [GPO-A-00-05-00041-00]; National
Science Foundation [0722354]; Ahmanson Foundation
FX The authors thank the National Institutes of Health (grant number
5R21AI079791 and 5R21AI076136), CONRAD (service contract number
PSA-08-10 and PPC-09-017), the International Partnership for
Microbicides, the US Agency for International Development (cooperative
agreement number GPO-A-00-05-00041-00) and the National Science
Foundation (award number 0722354) for funding support. The authors also
thank the Ahmanson Foundation for continued financial support of
advanced imaging at the House Ear Institute. The findings and
conclusions in this report are those of the authors and do not
necessarily represent the views of the Centers for Disease Control and
Prevention. The authors have no commercial or other associations that
might pose a conflict of interest. The use of trade names is for
identification only and does not constitute endorsement by the US
Department of Health and Human Services, the Public Health Service or
the Centers for Disease Control and Prevention.
NR 41
TC 20
Z9 20
U1 1
U2 10
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
BERKS, ENGLAND
SN 0022-2615
J9 J MED MICROBIOL
JI J. Med. Microbiol.
PD JUN
PY 2011
VL 60
IS 6
BP 828
EP 837
DI 10.1099/jmm.0.028225-0
PG 10
WC Microbiology
SC Microbiology
GA 774FJ
UT WOS:000291370200019
PM 21393449
ER
PT J
AU Abrams, JY
Maddox, RA
Harvey, AR
Schonberger, LB
Belay, ED
AF Abrams, Joseph Y.
Maddox, Ryan A.
Harvey, Alexis R.
Schonberger, Lawrence B.
Belay, Ermias D.
TI Travel History, Hunting, and Venison Consumption Related to Prion
Disease Exposure, 2006-2007 Food Net Population Survey
SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION
LA English
DT Article
ID CHRONIC WASTING DISEASE; UNITED-STATES; SURVEILLANCE; TRANSMISSION;
ILLNESS; HUMANS; DECADE; DEATH; DEER; BSE
AB The transmission of bovine spongiform encephalopathy (BSE) to human beings and the spread of chronic wasting disease (CWD) among cervids have prompted concerns about zoonotic transmission of prion diseases. Travel to the United Kingdom and other European countries, hunting for deer or elk, and venison consumption could result in the exposure of US residents to the agents that cause BSE and CWD. The Foodborne Diseases Active Surveillance Network 2006-2007 population survey was used to assess the prevalence of these behaviors among residents of 10 catchment areas across the United States. Of 17,372 survey respondents, 19.4% reported travel to the United Kingdom since 1980, and 29.5% reported travel to any of the nine European countries considered to be BSE-endemic since 1980. The proportion of respondents who had ever hunted deer or elk was 18.5%, and 1.2% had hunted deer or elk in a CWD-endemic area. More than two thirds (67.4%) reported having ever eaten deer or elk meat. Respondents who traveled spent more time in the United Kingdom (median 14 days) than in any other BSE-endemic country. Of the 11,635 respondents who had consumed venison, 59.8% ate venison at most one to two times during their year of highest consumption, and 88.6% had obtained all of their meat from the wild. The survey results were useful in determining the prevalence and frequency of behaviors that could be important factors for foodborne prion transmission. J Am Diet Assoc. 2011;111:858-863.
C1 [Abrams, Joseph Y.; Maddox, Ryan A.; Schonberger, Lawrence B.] Ctr Dis Control & Prevent, Prion & Publ Hlth Off, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
[Harvey, Alexis R.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
[Belay, Ermias D.] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
RP Abrams, JY (reprint author), Ctr Dis Control & Prevent, Prion & Publ Hlth Off, Natl Ctr Emerging & Zoonot Infect Dis, CDC Mailstop A39, Atlanta, GA 30333 USA.
EM hus4@cdc.gov
RI Belay, Ermias/A-8829-2013; Harvey, Alan/A-4911-2008
FU Centers for Disease Control and Prevention
FX This research project was funded by the Centers for Disease Control and
Prevention.
NR 24
TC 4
Z9 4
U1 1
U2 11
PU AMER DIETETIC ASSOC
PI CHICAGO
PA 120 S RIVERSIDE PLZ, STE 2000, CHICAGO, IL 60606-6995 USA
SN 0002-8223
J9 J AM DIET ASSOC
JI J. Am. Diet. Assoc.
PD JUN
PY 2011
VL 111
IS 6
BP 858
EP 863
DI 10.1016/j.jada.2011.03.015
PG 6
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 775KH
UT WOS:000291457700011
PM 21616198
ER
PT J
AU Brener, ND
Chriqui, JF
O'Toole, TP
Schwartz, MB
McManus, T
AF Brener, Nancy D.
Chriqui, Jamie F.
O'Toole, Terrence P.
Schwartz, Marlene B.
McManus, Tim
TI Establishing a Baseline Measure of School Wellness-Related Policies
Implemented in a Nationally Representative Sample of School Districts
SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION
LA English
DT Article
ID HEALTH POLICIES; PROGRAMS; QUALITY; STATES
AB The Child Nutrition and WIC Reauthorization Act of 2004 required school districts to establish a local school wellness policy by the first day of the 2006-2007 school year. To provide a baseline measure of the extent to which wellness-related policies were implemented in school districts nationwide in 2006, this study analyzed data from the 2006 School Health Policies and Programs Study (SHPPS). SHPPS used a cross-sectional design to measure policies and practices among a nationally representative sample of 538 public school districts. The authors applied a standardized wellness policy coding system to the data by matching each element to relevant questions from SHPPS and calculated the percentage of school districts meeting each element in the coding system. Statistical analyses included calculation of 95% confidence intervals for percentages and mean number of elements met in each area. In 2006, none of the districts met all elements included in the coding system for local wellness policies. In addition, the percentage of districts meeting each element varied widely. On average, districts met the greatest number of elements in the area of nutrition education and the least number of elements in the area of physical activity. By applying a coding system for district policies to an existing dataset, this study used a novel approach to determine areas of strength and weakness in the implementation of local school wellness-related policies in 2006. J Am Diet Assoc. 2011;111:894-901.
C1 [Brener, Nancy D.; O'Toole, Terrence P.; McManus, Tim] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA 30341 USA.
[O'Toole, Terrence P.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA.
[Chriqui, Jamie F.] Univ Illinois, Bridging Gap Program, Ctr Hlth Policy, Inst Hlth Res & Policy, Chicago, IL USA.
[Schwartz, Marlene B.] Yale Univ, Rudd Ctr Food Policy & Obes, New Haven, CT USA.
RP Brener, ND (reprint author), Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, MS K-33,4770 Buford Highway NE, Atlanta, GA 30341 USA.
EM nad1@cdc.gov
NR 24
TC 10
Z9 10
U1 1
U2 7
PU AMER DIETETIC ASSOC
PI CHICAGO
PA 120 S RIVERSIDE PLZ, STE 2000, CHICAGO, IL 60606-6995 USA
SN 0002-8223
J9 J AM DIET ASSOC
JI J. Am. Diet. Assoc.
PD JUN
PY 2011
VL 111
IS 6
BP 894
EP 901
DI 10.1016/j.jada.2011.03.016
PG 8
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 775KH
UT WOS:000291457700017
PM 21616204
ER
PT J
AU Kilpatrick, DR
Iber, JC
Chen, Q
Ching, KR
Yang, SJ
De, LN
Mandelbaum, MD
Emery, B
Campagnoli, R
Burns, CC
Kew, O
AF Kilpatrick, David R.
Iber, Jane C.
Chen, Qi
Ching, Karen
Yang, Su-Ju
De, Lina
Mandelbaum, Mark D.
Emery, Brian
Campagnoli, Ray
Burns, Cara C.
Kew, Olen
TI Poliovirus serotype-specific VP1 sequencing primers
SO JOURNAL OF VIROLOGICAL METHODS
LA English
DT Article
DE Poliovirus; PCR; Inosine-containing; Sequencing primers
ID VACCINE-RELATED POLIOVIRUSES; DEOXYINOSINE RESIDUES; MOLECULAR
EVOLUTION; CODON DEGENERACY; MIXED-BASE; IDENTIFICATION; RECOMBINANT;
CIRCULATION; POSITIONS; PROBES
AB The Global Polio Laboratory Network routinely uses poliovirus-specific PCR primers and probes to determine the serotype and genotype of poliovirus isolates obtained as part of global poliovirus surveillance. To provide detailed molecular epidemiologic information, poliovirus isolates are further characterized by sequencing the similar to 900-nucleotide region encoding the major capsid protein, VP1. It is difficult to obtain quality sequence information when clinical or environmental samples contain poliovirus mixtures. As an alternative to conventional methods for resolving poliovirus mixtures, sets of serotype-specific primers were developed for amplifying and sequencing the VP1 regions of individual components of mixed populations of vaccine-vaccine, vaccine-wild, and wild-wild polioviruses. Published by Elsevier B.V.
C1 [Kilpatrick, David R.] Ctr Dis Control & Prevent, Polio Mol Diagnost Dev Lab, Polio & Picornavirus Lab Branch, Div Viral Dis, Atlanta, GA 30333 USA.
RP Kilpatrick, DR (reprint author), Ctr Dis Control & Prevent, Polio Mol Diagnost Dev Lab, Polio & Picornavirus Lab Branch, Div Viral Dis, G-10, Atlanta, GA 30333 USA.
EM DKilpatrick@cdc.gov
NR 20
TC 26
Z9 26
U1 1
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-0934
J9 J VIROL METHODS
JI J. Virol. Methods
PD JUN
PY 2011
VL 174
IS 1-2
BP 128
EP 130
DI 10.1016/j.jviromet.2011.03.020
PG 3
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Virology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Virology
GA 776FX
UT WOS:000291521000021
PM 21440569
ER
PT J
AU Harcourt, JL
Caidi, H
Anderson, LJ
Haynes, LM
AF Harcourt, Jennifer L.
Caidi, Hayat
Anderson, Larry J.
Haynes, Lia M.
TI Evaluation of the Calu-3 cell line as a model of in vitro respiratory
syncytial virus infection
SO JOURNAL OF VIROLOGICAL METHODS
LA English
DT Article
DE Respiratory syncytial virus; Calu-3; Polarized cells; RSV
ID POLARIZED EPITHELIAL-CELLS; ACUTE BRONCHIOLITIS; PERSISTENCE; PROTEIN;
TRANSMISSION; REPLICATION; CHILDREN; INFANTS; CULTURE; TRACT
AB Respiratory syncytial virus (RSV) replication is primarily limited to the upper respiratory tract epithelium and primary, differentiated normal human bronchial epithelial cells (NHBE) have, therefore, been considered a good system for in vitro analysis of lung tissue response to respiratory virus infection and virus-host interactions. However, NHBE cells are expensive, difficult to culture, and vary with the source patient. An alternate approach is to use a continuous cell line that has features of bronchial epithelial cells such as Calu-3, an epithelial cell line derived from human lung adenocarcinoma, as an in vitro model of respiratory virus infection. The results show that Calu-3 fully polarize when grown on permeable supports as liquid-covered cultures. Polarized Calu-3 are susceptible to RSV infection and release infectious virus primarily from the apical surface, consistent with studies in NHBE cells. The data demonstrate that polarized Calu-3 may serve as a useful in vitro model to study host responses to RSV infection. Published by Elsevier B.V.
C1 [Harcourt, Jennifer L.; Caidi, Hayat; Haynes, Lia M.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Gastroenteritis & Resp Virus Lab Branch, Atlanta, GA 30333 USA.
[Anderson, Larry J.] Emory Univ, Childrens Ctr, Div Pediat Infect Dis, Atlanta, GA 30322 USA.
RP Haynes, LM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Gastroenteritis & Resp Virus Lab Branch, 1600 Clifton Rd NE,Mailstop G-18, Atlanta, GA 30333 USA.
EM zaq6@cdc.gov; foi0@cdc.gov; larry.anderson@emory.edu; loh5@cdc.gov
NR 36
TC 15
Z9 15
U1 1
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-0934
J9 J VIROL METHODS
JI J. Virol. Methods
PD JUN
PY 2011
VL 174
IS 1-2
BP 144
EP 149
DI 10.1016/j.jviromet.2011.03.027
PG 6
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Virology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Virology
GA 776FX
UT WOS:000291521000024
PM 21458491
ER
PT J
AU Curtis, KM
Tepper, NK
Marchbanks, PA
AF Curtis, Kathryn M.
Tepper, Naomi K.
Marchbanks, Polly A.
TI US Medical Eligibility Criteria for Contraceptive Use, 2010
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID UNINTENDED PREGNANCY; UNITED-STATES; HEALTH
AB Women with unintended pregnancies are more likely to experience poor pregnancy outcomes. For women with medical conditions, unintended pregnancy may worsen the condition and carry even greater risk of adverse pregnancy outcomes, including maternal and perinatal death. Although safe and highly effective contraceptive methods are available to prevent unintended pregnancy, there may be concerns about the safety of contraceptive methods among women with medical conditions. The Centers for Disease Control and Prevention (CDC) has recently developed the U. S. Medical Eligibility Criteria for Contraceptive Use, 2010, which provides evidence-based recommendations for the safety of contraceptive use among women with medical conditions. Most women, even those with medical conditions, can safely use most methods of contraception.
C1 [Curtis, Kathryn M.; Tepper, Naomi K.; Marchbanks, Polly A.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA.
RP Curtis, KM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, MS K-34,4770 Buford Highway NE, Atlanta, GA 30341 USA.
EM kmc6@cdc.gov
NR 17
TC 3
Z9 3
U1 0
U2 1
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD JUN
PY 2011
VL 20
IS 6
BP 825
EP 828
DI 10.1089/jwh.2011.2851
PG 4
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Obstetrics & Gynecology; Women's Studies
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Obstetrics & Gynecology; Women's Studies
GA 777CG
UT WOS:000291590700001
PM 21671772
ER
PT J
AU Ding, H
Santibanez, TA
Jamieson, DJ
Weinbaum, CM
Euler, GL
Grohskopf, LA
Lu, PJ
Singleton, JA
AF Ding, Helen
Santibanez, Tammy A.
Jamieson, Denise J.
Weinbaum, Cindy M.
Euler, Gary L.
Grohskopf, Lisa A.
Lu, Peng-Jun
Singleton, James A.
TI Influenza vaccination coverage among pregnant women-National 2009 H1N1
Flu Survey (NHFS)
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE H1N1; influenza; pregnancy; vaccination coverage
ID UNITED-STATES; SEASONAL INFLUENZA; 2009-JANUARY 2010; IMMUNIZATION;
ILLNESS; IMPACT
AB We sought to describe vaccination with influenza A (H1N1) 2009 monovalent (2009 H1N1) and trivalent seasonal (seasonal) vaccines among pregnant women during the 2009 through 2010 influenza season. A national H1N1 flu survey was conducted April through June 2010. The 2009 H1N1 and seasonal vaccination coverage estimates were 45.7% and 32.1%, respectively, among pregnant women aged 18-49 years. Receipt of a health care provider's recommendation for vaccination, perceived effectiveness of influenza vaccinations, and perceived high chance of influenza infection were independently associated with higher 2009 H1N1 and seasonal vaccination coverage. Pregnancy during October 2009 through January 2010 was independently associated with higher 2009 H1N1 vaccination coverage. The 2009 H1N1 vaccination level among pregnant women was higher than the seasonal vaccination level during the 2009 through 2010 season; it was also higher than vaccination among nonpregnant women with and without high-risk conditions. Health care providers and public health messaging played important roles in influencing vaccination behavior.
C1 [Ding, Helen; Santibanez, Tammy A.; Weinbaum, Cindy M.; Euler, Gary L.; Lu, Peng-Jun; Singleton, James A.] Ctr Dis Control & Prevent, Immunizat Serv Div, Atlanta, GA USA.
[Grohskopf, Lisa A.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
[Ding, Helen] Chenega Govt Consulting LLC, Ashburn, VA USA.
RP Ding, H (reprint author), 1600 Clifton Rd NE,MS-E62, Atlanta, GA 30333 USA.
EM hding@cdc.gov
FU Centers for Disease Control and Prevention; Association of Maternal and
Child Health Programs
FX Publication of this article was supported by the Centers for Disease
Control and Prevention and the Association of Maternal and Child Health
Programs.
NR 32
TC 47
Z9 51
U1 1
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUN
PY 2011
VL 204
IS 6
SU 1
BP S96
EP S106
DI 10.1016/j.ajog.2011.03.003
PG 11
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 772AF
UT WOS:000291201100017
PM 21640233
ER
PT J
AU Ellington, SR
Hartman, LK
Acosta, M
Martinez-Romo, M
Rubinson, L
Jamieson, DJ
Louie, J
AF Ellington, Sascha R.
Hartman, Laura K.
Acosta, Meileen
Martinez-Romo, Miguel
Rubinson, Lewis
Jamieson, Denise J.
Louie, Janice
TI Pandemic 2009 influenza A (H1N1) in 71 critically ill pregnant women in
California
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE critical illness; H1N1; influenza; intensive care; pregnant women
ID RESPIRATORY-FAILURE; A(H1N1) INFECTION; UNITED-STATES; CARE
AB We sought to describe the characteristics and clinical management of 71 critically ill pregnant women with pandemic 2009 influenza A (H1N1 [2009 H1N1]). This was a retrospective case series from April 23, 2009, through March 18, 2010, of pregnant women with 2009 H1N1 in intensive care units in California. Among 71 critically ill pregnant women with 2009 H1N1, rapid decline in clinical status was noted with a median duration of 1 day from hospital admission to intensive care unit admission. Adverse events were common, and included sepsis (n = 26), hematologic disorder (n = 17), and pneumothorax (n = 15). Of 42 women requiring invasive ventilation, 15 (36%) died. In total, 23 women required rescue therapies for severe gas exchange abnormalities. Adverse events were significantly associated with survival (P = .0003). Women who received early antiviral treatment were significantly more likely to survive (relative risk, 1.43; 95% confidence interval, 1.18-1.75). Critically ill pregnant women with 2009 H1N1 declined rapidly and developed frequent adverse events including death.
C1 [Ellington, Sascha R.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Hartman, Laura K.] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30341 USA.
[Hartman, Laura K.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA.
[Acosta, Meileen; Martinez-Romo, Miguel; Louie, Janice] Calif Dept Publ Hlth, Communicable Dis Emergency Response Branch, Div Communicable Dis Control, Richmond, CA USA.
[Rubinson, Lewis] US Dept HHS, Off Preparedness & Emergency, Washington, DC 20201 USA.
RP Ellington, SR (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,Mail Stop K-34, Atlanta, GA 30341 USA.
EM SEllington@cdc.gov
FU Centers for Disease Control and Prevention (CDC); Centers for Disease
Control and Prevention; Association of Maternal and Child Health
Programs
FX This research was supported in part by an appointment to the Research
Participation Program at the Centers for Disease Control and Prevention
(CDC) administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the US Department of Energy and
CDC.; Publication of this article was supported by the Centers for
Disease Control and Prevention and the Association of Maternal and Child
Health Programs.
NR 24
TC 17
Z9 18
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUN
PY 2011
VL 204
IS 6
SU 1
BP S21
EP S30
DI 10.1016/j.ajog.2011.02.038
PG 10
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 772AF
UT WOS:000291201100005
PM 21514554
ER
PT J
AU Mosby, LG
Ellington, SR
Forhan, SE
Yeung, LF
Perez, M
Shah, MM
MacFarlane, K
Laird, SK
House, LD
Jamieson, DJ
AF Mosby, Laura G.
Ellington, Sascha R.
Forhan, Sara E.
Yeung, Lorraine F.
Perez, Mirna
Shah, Melisa M.
MacFarlane, Kitty
Laird, Susan K.
House, Lawrence D.
Jamieson, Denise J.
TI The Centers for Disease Control and Prevention's maternal health
response to 2009 H1N1 influenza
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE 2009 H1N1 influenza; breastfeeding; CDC; pregnancy
ID PREGNANT-WOMEN; INFECTION; ILLNESS; IMPACT
AB We describe the efforts of the Maternal Health Team, which was formed to address the needs of pregnant and breastfeeding women during the Centers for Disease Control and Prevention's (CDC's) 2009 pandemic influenza A (2009 H1N1) emergency response. We examined the team's activities, constructed a timeline of key pandemic events, and analyzed the Maternal Health 2009 H1N1 inquiry database. During the pandemic response, 9 guidance documents that addressed the needs of pregnant and breastfeeding women and their providers were developed by the Maternal Health Team. The Team received 4661 maternal health-related inquiries that came primarily from the public (75.5%) and were vaccine related (69.3%). Peak inquiry volume coincided with peak hospitalizations (October-November 2009). The Maternal Health 2009 H1N1 inquiry database proved useful to identify information needs of the public and health care providers during the pandemic.
C1 [Ellington, Sascha R.; Perez, Mirna; MacFarlane, Kitty; House, Lawrence D.; Jamieson, Denise J.] CDC, Div Reprod Hlth, NCCDPHP, Atlanta, GA 30341 USA.
[Mosby, Laura G.; Shah, Melisa M.] Emory Univ, Sch Med, Atlanta, GA USA.
[Forhan, Sara E.] Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA USA.
[Yeung, Lorraine F.] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Laird, Susan K.] Ctr Dis Control & Prevent, CDC INFO Natl Contact Ctr, Atlanta, GA USA.
RP Jamieson, DJ (reprint author), CDC, Div Reprod Hlth, NCCDPHP, 4770 Buford Hwy NE,Mail Stop K-34, Atlanta, GA 30341 USA.
EM Djamieson@cdc.gov
OI Carlson, Laura/0000-0001-8119-9143
NR 16
TC 10
Z9 10
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUN
PY 2011
VL 204
IS 6
SU 1
BP S7
EP S12
DI 10.1016/j.ajog.2011.02.057
PG 6
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 772AF
UT WOS:000291201100003
PM 21457918
ER
PT J
AU Penman-Aguilar, A
Tucker, MJ
Groom, AV
Reilley, BA
Klepacki, S
Cullen, T
Gebremariam, C
Redd, JT
AF Penman-Aguilar, Ana
Tucker, Myra J.
Groom, Amy V.
Reilley, Brigg A.
Klepacki, Stephanie
Cullen, Theresa
Gebremariam, Cynthia
Redd, John T.
TI Validation of algorithm to identify American Indian/Alaska Native
pregnant women at risk from pandemic H1N1 influenza
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE American Indian; disease surveillance; H1N1; influenza; pregnancy;
special populations
AB Pregnant women and American Indian and Alaska Native people are at elevated risk of severe disease and mortality from 2009 pandemic influenza A/H1N1. We validated an electronic health record-based algorithm used by Indian Health Service to identify pregnant women in near real-time surveillance of pandemic influenza A/H1N1. We randomly selected a stratified sample of 515 patients at 3 Indian Health Service-funded hospitals with varied characteristics. With comprehensive review of patients' electronic health records as the gold standard, we calculated the positive predictive value and sensitivity of the pregnancy algorithm. The sensitivity of the algorithm at individual hospitals ranged from 94.1-96.0%. Positive predictive value ranged from 94.4-98.3%. Despite differences among hospitals on key characteristics, the pregnancy algorithm performed nearly equivalently with high positive predictive value and sensitivity at all facilities. It may prove helpful for surveillance during future epidemics and for targeting interventions for pregnant women and infants.
C1 [Penman-Aguilar, Ana; Tucker, Myra J.; Groom, Amy V.] Ctr Dis Control & Prevent, Womens Hlth & Fertil Branch, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Groom, Amy V.; Reilley, Brigg A.; Redd, John T.] Indian Hlth Serv, Albuquerque, NM USA.
[Klepacki, Stephanie; Cullen, Theresa; Gebremariam, Cynthia] Indian Hlth Serv, Rockville, MD USA.
RP Penman-Aguilar, A (reprint author), Ctr Dis Control & Prevent, Womens Hlth & Fertil Branch, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,Mailstop K-34, Atlanta, GA 30341 USA.
EM APenmanAguilar@cdc.gov
FU Centers for Disease Control and Prevention; Association of Maternal and
Child Health Programs; IHS; CDC
FX Publication of this article was supported by the Centers for Disease
Control and Prevention and the Association of Maternal and Child Health
Programs.; We wish to thank Denise Jamieson for her provision of subject
matter expertise. We also thank Audrey Lynch, Kelly Stewart, Rita
Harding, Luana Auker, Colleen Hayes, Jim Eller, and Teri Price for
technical consultation and assistance with data collection. This study
was supported by an Inter-agency Agreement between IHS and CDC.
NR 15
TC 3
Z9 3
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUN
PY 2011
VL 204
IS 6
SU 1
BP S46
EP S53
DI 10.1016/j.ajog.2011.03.004
PG 8
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 772AF
UT WOS:000291201100008
PM 21514920
ER
PT J
AU Poehling, KA
Szilagyi, PG
Staat, MA
Snively, BM
Payne, DC
Bridges, CB
Chu, SY
Light, LS
Prill, MM
Finelli, L
Griffin, MR
Edwards, KM
AF Poehling, Katherine A.
Szilagyi, Peter G.
Staat, Mary A.
Snively, Beverly M.
Payne, Daniel C.
Bridges, Carolyn B.
Chu, Susan Y.
Light, Laney S.
Prill, Mila M.
Finelli, Lyn
Griffin, Marie R.
Edwards, Kathryn M.
CA New Vaccine Surveillance Network
TI Impact of maternal immunization on influenza hospitalizations in infants
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE infants; influenza hospitalization; influenza vaccine; maternal
vaccination; vaccine effectiveness
ID PREGNANT-WOMEN; YOUNG-CHILDREN; RESPIRATORY ILLNESS; VIRUS INFECTION;
OBSTETRICIAN-GYNECOLOGISTS; VACCINES RECOMMENDATIONS;
ADVISORY-COMMITTEE; SEASONAL INFLUENZA; OUTPATIENT VISITS; PRACTICES
ACIP
AB We sought to determine whether maternal vaccination during pregnancy was associated with a reduced risk of laboratory-confirmed influenza hospitalizations in infants <6 months old. Active population-based, laboratory-confirmed influenza surveillance was conducted in children hospitalized with fever and/or respiratory symptoms in 3 US counties from November through April during the 2002 through 2009 influenza seasons. The exposure, influenza vaccination during pregnancy, and the outcome, positive/negative influenza testing among their hospitalized infants, were compared using logistic regression analyses. Among 1510 hospitalized infants <6 months old, 151 (10%) had laboratory-confirmed influenza and 294 (19%) mothers reported receiving influenza vaccine during pregnancy. Eighteen (12%) mothers of influenza-positive infants and 276 (20%) mothers of influenza-negative infants were vaccinated (unadjusted odds ratio, 0.53; 95% confidence interval, 0.32-0.88 and adjusted odds ratio, 0.52; 95% confidence interval, 0.30-0.91). Infants of vaccinated mothers were 45-48% less likely to have influenza hospitalizations than infants of unvaccinated mothers. Our results support the current influenza vaccination recommendation for pregnant women.
C1 [Poehling, Katherine A.] Wake Forest Univ, Sch Med, Dept Pediat, Winston Salem, NC 27109 USA.
[Poehling, Katherine A.] Wake Forest Univ, Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC 27109 USA.
[Snively, Beverly M.; Light, Laney S.] Wake Forest Univ, Sch Med, Dept Biostat Sci, Winston Salem, NC 27109 USA.
[Szilagyi, Peter G.] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA.
[Staat, Mary A.] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH USA.
[Payne, Daniel C.; Bridges, Carolyn B.; Prill, Mila M.; Finelli, Lyn] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Chu, Susan Y.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
[Griffin, Marie R.] Vanderbilt Univ, Med Ctr, Dept Internal Med, Nashville, TN USA.
[Griffin, Marie R.] Vanderbilt Univ, Med Ctr, Dept Prevent Med, Nashville, TN USA.
[Edwards, Kathryn M.] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA.
RP Poehling, KA (reprint author), Wake Forest Univ, Sch Med, Dept Pediat, Winston Salem, NC 27109 USA.
FU Centers for Disease Control and Prevention [U01/IP000017, U01/IP000022,
U01/IP000147]; National Institute of Allergy and Infectious Diseases
[K23 AI065805]; Wachovia Research Fund; Medimmune for respiratory
syncytial virus studies; Medimmune; Wyeth; Novartis; Sanofi-Pasteur;
CSL; Centers for Disease Control and Prevention; Association of Maternal
and Child Health Programs
FX This project was supported by Cooperative Agreement nos. U01/IP000017,
U01/IP000022, and U01/IP000147 from the Centers for Disease Control and
Prevention. Dr Poehling received support from National Institute of
Allergy and Infectious Diseases (K23 AI065805) and Wachovia Research
Fund. Dr Staat had funding from Medimmune for respiratory syncytial
virus studies; Dr Griffin received grant funding from Medimmune; Dr
Edwards received grant funding from Wyeth, Novartis, Sanofi-Pasteur, and
CSL with only the CSL funding being related to influenza studies. Dr
Staat was on the Medimmune Advisory Board, and Dr Edwards was a
consultant to NexBio. Drs Szilagyi, Snively, Payne, Bridges, Chu,
Finelli, and Ms Light and Ms Prill have no conflicts to report.;
Publication of this article was supported by the Centers for Disease
Control and Prevention and the Association of Maternal and Child Health
Programs.
NR 44
TC 98
Z9 101
U1 1
U2 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUN
PY 2011
VL 204
IS 6
SU 1
BP S141
EP S148
DI 10.1016/j.ajog.2011.02.042
PG 8
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 772AF
UT WOS:000291201100023
PM 21492825
ER
PT J
AU Rasmussen, SA
Kissin, DM
Yeung, LF
MacFarlane, K
Chu, SY
Turcios-Ruiz, RM
Mitchell, EW
Williams, J
Fry, AM
Hageman, J
Uyeki, TM
Jamieson, DJ
AF Rasmussen, Sonja A.
Kissin, Dmitry M.
Yeung, Lorraine F.
MacFarlane, Kitty
Chu, Susan Y.
Turcios-Ruiz, Reina M.
Mitchell, Elizabeth W.
Williams, Jennifer
Fry, Alicia M.
Hageman, Jeffrey
Uyeki, Timothy M.
Jamieson, Denise J.
CA Pandemic Influenza & Pregnancy Wor
TI Preparing for influenza after 2009 H1N1: special considerations for
pregnant women and newborns
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE 2009 H1N1; influenza; pandemic; pregnancy; seasonal
ID HEALTH-CARE WORKERS; A H1N1; UNITED-STATES; PANDEMIC INFLUENZA;
OBSTETRICIAN-GYNECOLOGISTS; NEURAMINIDASE INHIBITORS; VACCINATION
COVERAGE; RESPIRATORY ILLNESS; PRENATAL EXPOSURE; VIRUS INFECTION
AB Pregnant women and their newborn infants are at increased risk for influenza-associated complications, based on data from seasonal influenza and influenza pandemics. The Centers for Disease Control and Prevention (CDC) developed public health recommendations for these populations in response to the 2009 H1N1 pandemic. A review of these recommendations and information that was collected during the pandemic is needed to prepare for future influenza seasons and pandemics. The CDC convened a meeting entitled "Pandemic Influenza Revisited: Special Considerations for Pregnant Women and Newborns" on August 12-13, 2010, to gain input from experts and key partners on 4 main topics: antiviral prophylaxis and therapy, vaccine use, intrapartum/newborn (including infection control) issues, and nonpharmaceutical interventions and health care planning. Challenges to communicating recommendations regarding influenza to pregnant women and their health care providers were also discussed. After careful consideration of the available information and individual expert input, the CDC updated its recommendations for these populations for future influenza seasons and pandemics.
C1 [Rasmussen, Sonja A.; Yeung, Lorraine F.; Mitchell, Elizabeth W.; Williams, Jennifer] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Kissin, Dmitry M.; MacFarlane, Kitty; Chu, Susan Y.; Turcios-Ruiz, Reina M.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
[Fry, Alicia M.; Uyeki, Timothy M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Hageman, Jeffrey] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA.
RP Rasmussen, SA (reprint author), Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
FU Centers for Disease Control and Prevention; Association of Maternal and
Child Health Programs
FX Publication of this article was supported by the Centers for Disease
Control and Prevention and the Association of Maternal and Child Health
Programs.
NR 85
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U1 1
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PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUN
PY 2011
VL 204
IS 6
SU 1
BP S13
EP S20
DI 10.1016/j.ajog.2011.01.048
PG 8
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 772AF
UT WOS:000291201100004
PM 21333967
ER
PT J
AU Schuchat, A
AF Schuchat, Anne
TI Reflections on pandemics, past and present
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE history; influenza; pandemic; pregnancy
AB The author reflects on her personal experiences during the 2009 H1N1 influenza, acquired immune deficiency syndrome (AIDS), and severe acute respiratory syndrome (SARS) pandemics. The roles played by the Centers for Disease Control and Prevention related to pregnancy-associated influenza during the 2009 pandemic are described. Risk communication principles are summarized and resources provided.
C1 Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Schuchat, A (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Mailstop A-20, Atlanta, GA 30333 USA.
FU Centers for Disease Control and Prevention; Association of Maternal and
Child Health Programs
FX Publication of this article was supported by the Centers for Disease
Control and Prevention and the Association of Maternal and Child Health
Programs.
NR 3
TC 4
Z9 4
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUN
PY 2011
VL 204
IS 6
SU 1
BP S4
EP S6
DI 10.1016/j.ajog.2011.02.039
PG 3
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 772AF
UT WOS:000291201100002
PM 21419383
ER
PT J
AU SteelFisher, GK
Blendon, RJ
Bekheit, MM
Mitchell, EW
Williams, J
Lubell, K
Peugh, J
DiSogra, CA
AF SteelFisher, Gillian K.
Blendon, Robert J.
Bekheit, Mark M.
Mitchell, Elizabeth W.
Williams, Jennifer
Lubell, Keri
Peugh, Jordon
DiSogra, Charles A.
TI Novel pandemic A (H1N1) influenza vaccination among pregnant women:
motivators and barriers
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE H1N1; pregnant women; vaccination
ID UNITED-STATES; ASIAN INFLUENZA; DISPARITIES; COVERAGE; VACCINES; ADULTS;
RATES
AB We sought to examine motivators and barriers related to monovalent 2009 influenza A (H1N1) vaccination among pregnant women. We conducted a national poll of pregnant women using a random online sample (237) and opt-in supplement (277). In all, 42% of pregnant women reported getting the vaccine. Vaccination was positively associated with attitudinal factors including believing the vaccine is very safe or benefits the baby, and with provider recommendations. Women in racial/ethnic minority groups, women with less education, and women <35 years were less likely to get the vaccine and had differing views and experiences. Despite H1N1 vaccination rates that are higher than past seasonal influenza rates, barriers like safety concerns may persist in a pandemic. Messaging from providers that encourages women to believe the vaccine is very safe and benefits their baby may be compelling. Messaging and outreach during future pandemics may require customization to increase vaccination among high-risk groups.
C1 [SteelFisher, Gillian K.; Blendon, Robert J.; Bekheit, Mark M.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
[Blendon, Robert J.] Harvard Univ, John F Kennedy Sch Govt, Cambridge, MA 02138 USA.
[Mitchell, Elizabeth W.; Williams, Jennifer; Lubell, Keri] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Peugh, Jordon; DiSogra, Charles A.] Knowledge Networks, Menlo Pk, CA USA.
RP SteelFisher, GK (reprint author), Harvard Univ, Sch Publ Hlth, 665 Huntington Ave, Boston, MA 02115 USA.
FU Centers for Disease Control and Prevention; National Public Health
Information Coalition; Association of Maternal and Child Health Programs
FX The poll was funded under a cooperative agreement with the Centers for
Disease Control and Prevention and the National Public Health
Information Coalition.; Publication of this article was supported by the
Centers for Disease Control and Prevention and the Association of
Maternal and Child Health Programs.
NR 35
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Z9 47
U1 0
U2 8
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUN
PY 2011
VL 204
IS 6
SU 1
BP S116
EP S123
DI 10.1016/j.ajog.2011.02.036
PG 8
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 772AF
UT WOS:000291201100020
PM 21492827
ER
PT J
AU Thompson, M
Williams, J
Naleway, A
Li, DK
Chu, S
Bozeman, S
Hill, HA
Cragan, J
Shay, DK
AF Thompson, Mark
Williams, Jennifer
Naleway, Allison
Li, De-Kun
Chu, Susan
Bozeman, Sam
Hill, Holly A.
Cragan, Janet
Shay, David K.
CA Pregnancy Influenza Project
TI The Pregnancy and Influenza Project: design of an observational
case-cohort study to evaluate influenza burden and vaccine effectiveness
among pregnant women and their infants
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE infant; influenza; influenza vaccine; pregnancy; vaccine effectiveness
ID NEURAL-TUBE DEFECTS; ANTIBODY-RESPONSE; SOCIOECONOMIC-STATUS;
RESPIRATORY ILLNESS; HEALTH BEHAVIOR; UNITED-STATES; RISK; FEVER;
HOSPITALIZATIONS; IMMUNIZATION
AB The US Centers for Disease Control and Prevention is conducting an observational study of 300-500 women infected with influenza during pregnancy. Women are being recruited from members of the Kaiser Permanente health plan in 2 metropolitan areas before and during the 2010 through 2011 influenza season either following routine prenatal care visits or presentation with an acute respiratory infection. All enrolled mothers and their infants will be followed up through 1 month after delivery. Infants of mothers who had influenza during pregnancy and 1000 infants of mothers who were not diagnosed with influenza during pregnancy will be followed up for an additional 5 months. The Pregnancy and Influenza Project is focused on better understanding the burden of influenza during and after pregnancy and estimating the effectiveness of maternal influenza vaccination against influenza among women and their infants confirmed by real-time reverse transcription polymerase chain reaction assays.
C1 [Thompson, Mark; Shay, David K.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA.
[Williams, Jennifer; Cragan, Janet] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Chu, Susan] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA 30333 USA.
[Bozeman, Sam] ABT Associates Inc, Cambridge, MA 02138 USA.
[Hill, Holly A.] RTI Int, Res Triangle Pk, NC USA.
[Naleway, Allison] Kaiser Permanente Ctr Hlth Res, Portland, OR USA.
[Li, De-Kun] Kaiser Fdn Res Inst, Div Res, Oakland, CA USA.
RP Shay, DK (reprint author), Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd NE,Mailstop A-20, Atlanta, GA 30333 USA.
EM dks4@cdc.gov
OI Naleway, Allison/0000-0001-5747-4643; Shay, David/0000-0001-9619-4820
FU Centers for Disease Control and Prevention [200-2010-F-33132];
Association of Maternal and Child Health Programs
FX Supported by the Centers for Disease Control and Prevention (Contract
200-2010-F-33132 to Abt Associates Inc).; Publication of this article
was supported by the Centers for Disease Control and Prevention and the
Association of Maternal and Child Health Programs.
NR 41
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U1 1
U2 10
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUN
PY 2011
VL 204
IS 6
SU 1
BP S69
EP S76
DI 10.1016/j.ajog.2011.01.006
PG 8
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 772AF
UT WOS:000291201100012
PM 21411050
ER
PT J
AU Ellingson, K
Seem, D
Nowicki, M
Strong, DM
Kuehnert, MJ
AF Ellingson, K.
Seem, D.
Nowicki, M.
Strong, D. M.
Kuehnert, M. J.
CA Organ Procurement Org Nucleic Acid
TI Estimated Risk of Human Immunodeficiency Virus and Hepatitis C Virus
Infection among Potential Organ Donors from 17 Organ Procurement
Organizations in the United States
SO AMERICAN JOURNAL OF TRANSPLANTATION
LA English
DT Article
DE Donor screening; infection risk; nucleic acid testing; organ
transplantation
ID ACID TESTING NAT; TISSUE DONORS; TRANSMISSION; BLOOD; HCV; TYPE-1;
HIV-1; HTLV; HBV
AB To prevent unintentional transmission of bloodborne pathogens through organ transplantation, organ procurement organizations (OPOs) screen potential donors by serologic testing to identify human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection. Newly acquired infection, however, may be undetectable by serologic testing. Our objective was to estimate the incidence of undetected infection among potential organ donors and to assess the significance of risk reductions conferred by nucleic acid testing (NAT) versus serology alone. We calculated prevalence of HIV and HCV-stratified by OPO risk designation-in 13 667 potential organ donors managed by 17 OPOs from 1/1/2004 to 7/1/2008. We calculated incidence of undetected infection using the incidence-window period approach. The prevalence of HIV was 0.10% for normal risk potential donors and 0.50% for high risk potential donors; HCV prevalence was 3.45% and 18.20%, respectively. For HIV, the estimated incidence of undetected infection by serologic screening was 1 in 50 000 for normal risk potential donors and 1 in 11 000 for high risk potential donors; for HCV, undetected incidence by serologic screening was 1 in 5000 and 1 in 1000, respectively. Projected estimates of undetected infection with NAT screening versus serology alone suggest that NAT screening could significantly reduce the rate of undetected HCV for all donor risk strata.
C1 [Ellingson, K.; Seem, D.; Kuehnert, M. J.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA.
[Nowicki, M.] Mendez Natl Inst Transplantat, Los Angeles, CA USA.
[Nowicki, M.] Univ So Calif, Los Angeles, CA USA.
[Strong, D. M.] Univ Washington, Sch Med, Seattle, WA USA.
RP Ellingson, K (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA.
EM KEllingson@cdc.gov; MKuehnert@cdc.gov
NR 21
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Z9 27
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1600-6135
J9 AM J TRANSPLANT
JI Am. J. Transplant.
PD JUN
PY 2011
VL 11
IS 6
BP 1201
EP 1208
DI 10.1111/j.1600-6143.2011.03518.x
PG 8
WC Surgery; Transplantation
SC Surgery; Transplantation
GA 772ZV
UT WOS:000291277700016
PM 21645253
ER
PT J
AU Ison, MG
Llata, E
Conover, CS
Friedewald, JJ
Gerberg, SI
Grigoryan, A
Heneine, W
Millis, JM
Simon, DM
Teo, CG
Kuehnert, MJ
AF Ison, M. G.
Llata, E.
Conover, C. S.
Friedewald, J. J.
Gerberg, S. I.
Grigoryan, A.
Heneine, W.
Millis, J. M.
Simon, D. M.
Teo, C. -G.
Kuehnert, M. J.
CA HIV-HCV Transplantation
TI Transmission of Human Immunodeficiency Virus and Hepatitis C Virus From
an Organ Donor to Four Transplant Recipients
SO AMERICAN JOURNAL OF TRANSPLANTATION
LA English
DT Article
DE Donor-to-host transmission; HIV; HCV; nucleic acid diagnostics
ID MARGINAL DONORS; CLINICAL TRANSPLANTATION; KIDNEY-TRANSPLANTATION;
LIVER-TRANSPLANTATION; CONSENSUS CONFERENCE; HIV TRANSMISSION; TYPE-1;
INFECTION; CLUSTER; STATE
AB In 2007, a previously uninfected kidney transplant recipient tested positive for human immunodeficiency virus type 1 (HIV) and hepatitis C virus (HCV) infection. Clinical information of the organ donor and the recipients was collected by medical record review. Sera from recipients and donor were tested for serologic and nucleic acid-based markers of HIV and HCV infection, and isolates were compared for genetic relatedness. Routine donor serologic screening for HIV and HCV infection was negative; the donor's only known risk factor for HIV was having sex with another man. Four organs (two kidneys, liver and heart) were transplanted to four recipients. Nucleic acid testing (NAT) of donor sera and posttransplant sera from all recipients were positive for HIV and HCV. HIV nucleotide sequences were indistinguishable between the donor and four recipients, and HCV subgenomic sequences clustered closely together. Two patients subsequently died and the transplanted organs failed in the other two patients. This is the first recognized cotransmission of HIV and HCV from an organ donor to transplant recipients. Routine posttransplant HIV and HCV serological testing and NAT of recipients of organs from donors with suspected risk factors should be considered as routine practice.
C1 [Llata, E.; Kuehnert, M. J.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA.
[Ison, M. G.] Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA.
[Ison, M. G.; Friedewald, J. J.] Northwestern Univ, Feinberg Sch Med, Div Organ Transplantat, Chicago, IL 60611 USA.
[Llata, E.; Grigoryan, A.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA.
[Conover, C. S.] Illinois Dept Publ Hlth, Branch Lab, Div HIV AIDS Prevent, Div Infect Dis, Springfield, IL 62761 USA.
[Friedewald, J. J.] Northwestern Univ, Feinberg Sch Med, Div Nephrol Hypertens, Chicago, IL 60611 USA.
[Gerberg, S. I.] Cook Cty Dept Publ Hlth, Chicago, IL USA.
[Heneine, W.] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Atlanta, GA USA.
[Millis, J. M.] Univ Chicago, Sect Transplantat, Chicago, IL 60637 USA.
[Simon, D. M.] Rush Univ, Med Ctr, Infect Dis Sect, Chicago, IL 60612 USA.
[Teo, C. -G.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA.
RP Kuehnert, MJ (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA.
EM mgk8@cdc.gov
OI Friedewald, John/0000-0002-9344-9928
FU ViraCor; Abbott Molecular; Biogen Idec
FX No commercial organization prepared or funded this document. The authors
of this manuscript have no conflicts of interest to disclose as
described by the American Journal of Transplantation, except for MG Ison
who discloses research funding, paid to Northwestern University, by
ViraCor and paid consultation by Abbott Molecular, Biogen Idec, and
ViraCor. The findings and conclusions in this report are those of the
authors and do not necessarily represent the official position of the
Centers for Disease Control and Prevention.
NR 40
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Z9 44
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1600-6135
J9 AM J TRANSPLANT
JI Am. J. Transplant.
PD JUN
PY 2011
VL 11
IS 6
BP 1218
EP 1225
DI 10.1111/j.1600-6143.2011.03597.x
PG 8
WC Surgery; Transplantation
SC Surgery; Transplantation
GA 772ZV
UT WOS:000291277700018
PM 21645254
ER
PT J
AU Luby, SP
Agboatwalla, M
Hoekstra, RM
AF Luby, Stephen P.
Agboatwalla, Mubina
Hoekstra, Robert M.
TI The Variability of Childhood Diarrhea in Karachi, Pakistan, 2002-2006
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; WATER; HEALTH; PREVALENCE; MULTICOUNTRY;
COMMUNITIES; BANGLADESH; MORTALITY; COUNTRIES; PROGRAMS
AB Diarrhea burden is often estimated using cross-sectional surveys. We measured variability in diarrhea prevalence among children <5 years of age living in squatter settlements in central Karachi, Pakistan. We pooled data from nonintervention control households from studies conducted from 2002 through 2006. The prevalence of diarrhea varied on average by 29% from one week to the next, by 37% from one month to the next, and during peak diarrhea season by 32% from one year to the next. During 24 months when the same nine neighborhoods were under surveillance, each month the prevalence of diarrhea varied by at least an order of magnitude from the lowest to the highest prevalence neighborhood, and each neighborhood recorded the highest diarrhea prevalence during at least one month. Cross-sectional surveys are unreliable measures of diarrhea prevalence.
C1 [Luby, Stephen P.] Int Ctr Diarrhoeal Dis Res, Ctr Communicable Dis, Dhaka 1000, Bangladesh.
[Luby, Stephen P.] Ctr Dis Control & Prevent, Global Dis Detect & Emergency Response Div, Atlanta, GA USA.
[Agboatwalla, Mubina] Hlth Oriented Prevent Educ, Karachi, Pakistan.
[Hoekstra, Robert M.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA.
RP Luby, SP (reprint author), Int Ctr Diarrhoeal Dis Res, Ctr Communicable Dis, GPO Box 128, Dhaka 1000, Bangladesh.
EM sluby@icddrb.org; agboat@hope-ngo.com; rth6@cdc.gov
FU Procter Gamble Company; U.S. Centers for Disease Control and Prevention
FX This work was supported by the Procter & Gamble Company and the U.S.
Centers for Disease Control and Prevention.
NR 29
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Z9 4
U1 0
U2 6
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD JUN
PY 2011
VL 84
IS 6
BP 870
EP 877
DI 10.4269/ajtmh.2011.10-0364
PG 8
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 773TI
UT WOS:000291333200007
PM 21633021
ER
PT J
AU Osorio, JE
Brewoo, JN
Silengo, SJ
Arguello, J
Moldovan, IR
Tary-Lehmann, M
Powell, TD
Livengood, JA
Kinney, RM
Huang, CYH
Stinchcomb, DT
AF Osorio, Jorge E.
Brewoo, Joseph N.
Silengo, Shawn J.
Arguello, John
Moldovan, Ioana R.
Tary-Lehmann, Magdalena
Powell, Tim D.
Livengood, Jill A.
Kinney, Richard M.
Huang, Claire Y. -H.
Stinchcomb, Dan T.
TI Efficacy of a Tetravalent Chimeric Dengue Vaccine (DENVax) in Cynomolgus
Macaques
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID CLINICAL LABORATORY RESPONSES; VIRUS-VACCINE; STRAIN 16681; CANDIDATE
VACCINE; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; ADULT VOLUNTEERS;
RHESUS-MONKEYS; PDK-53 VIRUS; PATHOGENESIS
AB Three tetravalent formulations of chimeric dengue (DENVax) viruses containing the pre-membrane and envelope genes of serotypes 1-4 expressed by the attenuated DENV-2 PDK-53 genome were tested for safety, immunogenicity, and efficacy in cynomolgus macaques (Macaca fascicularis). Subcutaneous injection of the DENVax formulations was well-tolerated. Low levels of viremia of only one of the four vaccine viruses were detected yet virus neutralizing antibody titers were induced against all four dengue virus serotypes after one or two administrations of vaccine. All animals immunized with the high-dose formulation were protected from viremia, and all immunized animals were completely protected from DENV-3 and DENV-4 challenge. A lower dose of DENVax formulation partially protected animals from DENV-1. or DENV-2 challenge. In contrast, all control animals developed high levels of viremia for multiple days after challenge with DENV 1-4. This study highlights the immunogenicity and efficacy of the tetravalent DENVax formulations in nonhuman primates.
C1 [Osorio, Jorge E.; Brewoo, Joseph N.] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA.
[Osorio, Jorge E.; Brewoo, Joseph N.] Inviragen Inc, Madison, WI USA.
[Silengo, Shawn J.; Arguello, John; Powell, Tim D.; Livengood, Jill A.; Kinney, Richard M.; Stinchcomb, Dan T.] Inviragen Inc, Ft Collins, CO USA.
[Arguello, John; Kinney, Richard M.; Huang, Claire Y. -H.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA.
[Moldovan, Ioana R.; Tary-Lehmann, Magdalena] Cellular Technol Ltd, Shaker Hts, OH USA.
RP Osorio, JE (reprint author), Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA.
EM Osorio@svm.vetmed.wisc.edu; jbrewoo@inviragen.com;
ssilengo@inviragen.com; jarguello@inviragen.com;
ioana.moldovan@immunospot.com; magda.tary-lehmann@immunospot.com;
tpowell@inviragen.com; jlivengood@inviragen.com; zzkinney@msn.com;
yxh0@cdc.gov; dstinchcomb@inviragen.com
OI Stinchcomb, Dan/0000-0002-3634-7503
FU National Institutes of Health [5-U01-AI070443]
FX This study was partially supported by National Institutes of Health
grant 5-U01-AI070443.
NR 41
TC 47
Z9 49
U1 0
U2 5
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD JUN
PY 2011
VL 84
IS 6
BP 978
EP 987
DI 10.4269/ajtmh.2011.10-0592
PG 10
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 773TI
UT WOS:000291333200023
PM 21633037
ER
PT J
AU Nathanson, N
Kew, OM
AF Nathanson, Neal
Kew, Olen M.
TI Poliovirus Vaccines: Past, Present, and Future
SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
LA English
DT Article
ID POLIOMYELITIS ERADICATION; GLOBAL ERADICATION; UNITED-STATES;
IMMUNIZATION; VACCINATION; NIGERIA; EPIDEMIOLOGY; EMERGENCE; RISKS;
INDIA
C1 [Nathanson, Neal] Univ Penn, Sch Med, Off Global Hlth Programs, Philadelphia, PA 19104 USA.
[Nathanson, Neal] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA.
[Kew, Olen M.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA USA.
RP Nathanson, N (reprint author), Univ Penn, Sch Med, Off Global Hlth Programs, 1007 Blockley Hall,423 Guardian Dr, Philadelphia, PA 19104 USA.
EM nathansn@upenn.edu
NR 43
TC 2
Z9 2
U1 1
U2 7
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 1072-4710
J9 ARCH PEDIAT ADOL MED
JI Arch. Pediatr. Adolesc. Med.
PD JUN
PY 2011
VL 165
IS 6
BP 489
EP 491
PG 3
WC Pediatrics
SC Pediatrics
GA 773QC
UT WOS:000291321000002
PM 21646582
ER
PT J
AU Mersereau, P
Williams, J
Collier, SA
Mulholland, C
Turay, K
Prue, C
AF Mersereau, Patricia
Williams, Jennifer
Collier, Sarah A.
Mulholland, Celene
Turay, Khadija
Prue, Christine
TI Barriers to Managing Diabetes During Pregnancy: The Perceptions of
Health Care Practitioners
SO BIRTH-ISSUES IN PERINATAL CARE
LA English
DT Article
DE barriers; diabetes; glycemic control; pregnancy
ID CONGENITAL-ANOMALIES; PRECONCEPTION CARE; WOMEN; MELLITUS; INFANTS;
RISK; RECOMMENDATIONS; MALFORMATIONS; INTERVENTION; MOTHERS
AB Background:
Uncontrolled pregestational diabetes in pregnancy is associated with an increased risk for a major birth defect and additional adverse pregnancy outcomes. The study objective was to investigate the concerns of health care practitioners who care for women with a history of diabetes during pregnancy and their perceptions of attitudes and barriers to achieving good glycemic control.
Methods:
Focus groups were conducted with physicians, midlevel practitioners, and certified diabetes educators in Atlanta, Georgia. Practitioners were eligible if they actively practiced, primarily in outpatient facilities in Atlanta, and were neither students nor interns. Six focus groups, two of each practitioner type, were conducted.
Results:
Practitioners stated that few of their patients planned their pregnancies. Practitioners perceived that pregnant women were concerned primarily about their babies and might not be aware of complications with their personal health. Their perceptions of the greatest barriers to glycemic control for women involved lack of knowledge, lack of access, and attitude.
Conclusions:
Educating women with diabetes about the importance of using effective birth control until they have achieved good glycemic control can help reduce the risk for adverse pregnancy outcomes. Motivators and barriers for a woman with diabetes to achieve glycemic control before, during, and after pregnancy should be considered when developing approaches to improve outcomes. Helping practitioners know what and how to address the needs of childbearing women with or at risk for diabetes can be beneficial. Additional efforts to increase women's knowledge about diabetes and pregnancy and to develop effective strategies to encourage women's achievement and maintenance of glycemic control before, during, and after pregnancy are needed. (BIRTH 38:2 June 2011).
C1 [Mersereau, Patricia] CDC, NCBDDD, Atlanta, GA 30333 USA.
[Williams, Jennifer] CDC, US Publ Hlth Serv, NCBDDD, Atlanta, GA 30333 USA.
[Collier, Sarah A.] CDC, Atlanta Res & Educ Fdn, Natl Ctr Emerging & Zoonot Infect Dis NCZVED, Atlanta, GA 30333 USA.
[Mulholland, Celene] Univ Calif Los Angeles, Los Angeles, CA USA.
[Turay, Khadija] Univ N Carolina, Chapel Hill, NC USA.
[Prue, Christine] CDC, NCZVED, Atlanta, GA 30333 USA.
RP Mersereau, P (reprint author), CDC, NCBDDD, 1600 Clifton Rd,NE,MS E-86, Atlanta, GA 30333 USA.
NR 33
TC 5
Z9 5
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7659
J9 BIRTH-ISS PERINAT C
JI Birth-Issue Perinat. Care
PD JUN
PY 2011
VL 38
IS 2
BP 142
EP 149
DI 10.1111/j.1523-536X.2010.00464.x
PG 8
WC Nursing; Obstetrics & Gynecology; Pediatrics
SC Nursing; Obstetrics & Gynecology; Pediatrics
GA 766SW
UT WOS:000290807800008
PM 21599737
ER
PT J
AU Hunsperger, E
Beltran, M
Acosta, LN
Jordan-Munoz, J
Torres, J
Luce, R
Tomashek, KM
AF Hunsperger, Elizabeth
Beltran, Manuela
Acosta, Luz Nereida
Jordan-Munoz, Jorge
Torres, Jomil
Luce, Richard
Tomashek, Kay M.
TI Serological Evaluation of Suspected West Nile Virus Human Cases
following Its Introduction during a Dengue Outbreak in Puerto Rico in
2007
SO CLINICAL AND VACCINE IMMUNOLOGY
LA English
DT Article
ID LINKED IMMUNOSORBENT ASSAYS; TRANSCRIPTASE-PCR ASSAY; NS1 ANTIGEN;
DIAGNOSIS; INFECTIONS; TRANSMISSION; ANTIBODIES; IMMUNOASSAY; JAPANESE;
HORSES
AB A laboratory testing algorithm was evaluated to confirm West Nile virus (WNV) infection in human serum following the introduction of the virus in Puerto Rico in 2007. This testing algorithm used two standard diagnostic assays, the IgM antibody capture enzyme-linked immunosorbent assay (MAC ELISA) and real-time reverse transcriptase PCR (RT-PCR), along with two nonconventional assays, the nonstructural protein 1 (NS1) ELISA and a 90%-plaque-reduction neutralization test (PRNT(90)) with IgG depletion for dengue virus (DENV) and WNV. A total of 2,321 serum samples from suspected WNV human cases were submitted for testing. Approximately one-third (867, 37%) were cross-reactive for DENV and WNV by MAC ELISA and had negative RT-PCR results for both viruses. Of a subset of 43 samples tested, 31 (72%) of these cases were identified as positive for DENV in the PRNT90 with IgG depletion and 8 (19%) were positive in the DENV NS1 antigen ELISA. These two assays combined differentiated 36 (84%) of the samples that could not be diagnosed using the standard diagnostic testing methods.
C1 [Hunsperger, Elizabeth; Beltran, Manuela; Acosta, Luz Nereida; Jordan-Munoz, Jorge; Luce, Richard; Tomashek, Kay M.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Dengue Branch, San Juan, PR USA.
[Torres, Jomil] Puerto Rico Dept Hlth, San Juan, PR USA.
RP Hunsperger, E (reprint author), 1324 Calle Canada, San Juan, PR 00920 USA.
EM enh4@cdc.gov
NR 24
TC 4
Z9 4
U1 0
U2 6
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1556-6811
J9 CLIN VACCINE IMMUNOL
JI Clin. Vaccine Immunol.
PD JUN
PY 2011
VL 18
IS 6
BP 978
EP 983
DI 10.1128/CVI.00040-11
PG 6
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 771HH
UT WOS:000291147300012
PM 21508167
ER
PT J
AU O'Neal, S
Noh, J
Wilkins, P
Keene, W
Lambert, W
Anderson, J
Luman, JC
Townes, J
AF O'Neal, Seth
Noh, John
Wilkins, Patricia
Keene, William
Lambert, William
Anderson, James
Luman, Jenifer Compton
Townes, John
TI Taenia solium Tapeworm Infection, Oregon, 2006-2009
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID LOS-ANGELES-COUNTY; UNITED-STATES; NEUROCYSTICERCOSIS; CYSTICERCOSIS;
ANTIGENS; TRAVEL; ASSAY
AB Neurocysticercosis (NCC) is a parasitic infection of the central nervous system caused by Taenia solium larval cysts. Its epidemiology in cysticercosis-nonendemic regions is poorly understood, and the role of public health institutions is unclear. To determine the incidence of NCC and to pilot screening of household contacts for tapeworms, we conducted population-based active surveillance in Oregon. We screened for T. solium infection by examining hospital billing codes and medical charts for NCC diagnosed during January 1, 2006 December 31, 2009 and collecting fecal and blood samples from household contacts of recent case-patients. We identified 87 case-patients, for an annual incidence of 0.5 cases per 100,000 general population and 5.8 cases per 100,000 Hispanics. In 22 households, we confirmed 2 additional NCC case-patients but no current adult intestinal tapeworm infections. NCC is of clinical and public health concern in Oregon, particularly among Hispanics. Public health intervention should focus on family members because household investigations can identify additional case-patients.
C1 [O'Neal, Seth; Lambert, William; Anderson, James; Luman, Jenifer Compton; Townes, John] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Noh, John; Wilkins, Patricia] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Keene, William] Oregon Dept Human Serv, Portland, OR USA.
RP O'Neal, S (reprint author), 3181 SW Sam Jackson Pk Rd,CSB 681, Portland, OR 97239 USA.
EM oneals@ohsu.edu
FU Centers for Disease Control and Prevention Emerging Infections; Oregon
Clinical and Translational Research Institute; National Center for
Research Resources, National Institutes of Health [UL1 RR024140];
National Institutes of Health Roadmap for Medical Research
FX This work was supported by the Centers for Disease Control and
Prevention Emerging Infections Program and by the Oregon Clinical and
Translational Research Institute, grant number UL1 RR024140 from the
National Center for Research Resources, a component of the National
Institutes of Health, and National Institutes of Health Roadmap for
Medical Research.
NR 20
TC 11
Z9 11
U1 0
U2 4
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD JUN
PY 2011
VL 17
IS 6
BP 1030
EP 1036
DI 10.3201/eid1706.101397
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 772JG
UT WOS:000291229600010
PM 21749764
ER
PT J
AU De Cock, KM
Jaffe, HW
Curran, JW
AF De Cock, Kevin M.
Jaffe, Harold W.
Curran, James W.
TI Reflections on 30 Years of AIDS
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
AB June 2011 marks the 30th anniversary of the first description of what became known as HIV/AIDS, now one of history's worst pandemics. The basic public health tools of surveillance and epidemiologic investigation helped define the epidemic and led to initial prevention recommendations. Features of the epidemic, including the zoonotic origin of HIV and its spread through global travel, are central to the concept of emerging infectious diseases. As the epidemic expanded into developing countries, new models of global health and new global partnerships developed. Advocacy groups played a major role in mobilizing the response to the epidemic, having human rights as a central theme. Through the commitments of governments and private donors, modern HIV treatment has become available throughout the developing world. Although the end of the epidemic is not yet in sight and many challenges remain, the response has been remarkable and global health has changed for the better.
C1 [De Cock, Kevin M.; Jaffe, Harold W.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Curran, James W.] Emory Univ, Atlanta, GA 30322 USA.
[Curran, James W.] Emory Ctr AIDS Res, Atlanta, GA USA.
RP De Cock, KM (reprint author), Ctr Dis Control & Prevent, Mailstop D69,1600 Clifton Rd NE, Atlanta, GA 30333 USA.
EM kmd2@cdc.gov
NR 0
TC 23
Z9 23
U1 2
U2 13
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD JUN
PY 2011
VL 17
IS 6
BP 1044
EP 1048
DI 10.3201/eid1706.100184
PG 5
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 772JG
UT WOS:000291229600012
PM 21749766
ER
PT J
AU Medalla, F
Sjolund-Karlsson, M
Shin, S
Harvey, E
Joyce, K
Theobald, L
Nygren, BL
Pecic, G
Gay, K
Austin, J
Stuart, A
Blanton, E
Mintz, ED
Whichard, JM
Barzilay, EJ
AF Medalla, Felicita
Sjoelund-Karlsson, Maria
Shin, Sanghyuk
Harvey, Emily
Joyce, Kevin
Theobald, Lisa
Nygren, Benjamin L.
Pecic, Gary
Gay, Kathryn
Austin, Jana
Stuart, Andrew
Blanton, Elizabeth
Mintz, Eric D.
Whichard, Jean M.
Barzilay, Ezra J.
TI Ciprofloxacin-Resistant Salmonella enterica Serotype Typhi, United
States, 1999-2008
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID ANTIMICROBIAL-RESISTANCE; ESCHERICHIA-COLI; FEVER
AB We report 9 ciprofloxacin-resistant Salmonella enterica serotype Typhi isolates submitted to the US National Antimicrobial Resistance Monitoring System during 1999-2008. The first 2 had indistinguishable pulsed-field gel electrophoresis patterns and identical gyrA and parC mutations. Eight of the 9 patients had traveled to India within 30 days before illness onset.
C1 [Medalla, Felicita; Sjoelund-Karlsson, Maria; Joyce, Kevin; Theobald, Lisa; Nygren, Benjamin L.; Pecic, Gary; Gay, Kathryn; Austin, Jana; Stuart, Andrew; Blanton, Elizabeth; Mintz, Eric D.; Whichard, Jean M.; Barzilay, Ezra J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Shin, Sanghyuk] Calif Emerging Infect Program, Oakland, CA USA.
[Harvey, Emily] Massachusetts Dept Publ Hlth, Jamaica Plain, MA USA.
RP Medalla, F (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D63, Atlanta, GA 30333 USA.
EM fmedalla@cdc.gov
FU US Food and Drug Administration
FX The US Food and Drug Administration provides funding support for NARMS.
NR 15
TC 20
Z9 21
U1 0
U2 3
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD JUN
PY 2011
VL 17
IS 6
BP 1095
EP 1098
DI 10.3201/eid1706.100594
PG 4
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 772JG
UT WOS:000291229600025
PM 21749779
ER
PT J
AU Harris, JR
Martin, D
Lichiello, P
Ahmed, F
Friedman, C
Williams, B
AF Harris, Jeffrey R.
Martin, Diane
Lichiello, Patricia
Ahmed, Faruque
Friedman, Carol
Williams, Barbara
TI Community Vaccinators in the Workplace
SO EMERGING INFECTIOUS DISEASES
LA English
DT Letter
ID RANDOMIZED CONTROLLED-TRIAL; INFLUENZA VACCINATION; UNITED-STATES;
ADULTS
C1 [Harris, Jeffrey R.] Univ Washington, Hlth Promot Res Ctr, Sch Publ Hlth, Seattle, WA 98105 USA.
[Ahmed, Faruque; Friedman, Carol] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Harris, JR (reprint author), Univ Washington, Hlth Promot Res Ctr, Sch Publ Hlth, 1107 NE 45th St,Ste 200, Seattle, WA 98105 USA.
EM jh7@uw.edu
OI Harris, Jeffrey/0000-0001-8728-7195
NR 10
TC 0
Z9 0
U1 0
U2 1
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD JUN
PY 2011
VL 17
IS 6
BP 1134
EP 1135
DI 10.3201/eid1706.101763
PG 2
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 772JG
UT WOS:000291229600039
PM 21749793
ER
PT J
AU Cox, CM
Neises, D
Garten, RJ
Bryant, B
Hesse, RA
Anderson, GA
Trevino-Garrison, I
Shu, B
Lindstrom, S
Klimov, AI
Finelli, L
AF Cox, Chad M.
Neises, Daniel
Garten, Rebecca J.
Bryant, Bill
Hesse, Richard A.
Anderson, Gary A.
Trevino-Garrison, Ingrid
Shu, Bo
Lindstrom, Stephen
Klimov, Alexander I.
Finelli, Lyn
TI Swine Influenza Virus A (H3N2) Infection in Human, Kansas, USA, 2009
SO EMERGING INFECTIOUS DISEASES
LA English
DT Letter
ID TRANSMISSION; WISCONSIN; CANADA; PIGS
C1 [Cox, Chad M.; Garten, Rebecca J.; Shu, Bo; Lindstrom, Stephen; Klimov, Alexander I.; Finelli, Lyn] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Neises, Daniel; Trevino-Garrison, Ingrid] Kansas Dept Hlth & Environm, Topeka, KS USA.
[Bryant, Bill] Kansas Anim Hlth Dept, Topeka, KS USA.
[Hesse, Richard A.; Anderson, Gary A.] Kansas State Vet Diagnost Lab, Manhattan, KS USA.
RP Cox, CM (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop A32, Atlanta, GA 30333 USA.
EM cyv5@cdc.gov
NR 10
TC 26
Z9 26
U1 0
U2 3
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD JUN
PY 2011
VL 17
IS 6
BP 1143
EP 1144
DI 10.3201/eid1706.101488
PG 2
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 772JG
UT WOS:000291229600044
PM 21749798
ER
PT J
AU Lo, YC
Kintziger, KW
Carson, HJ
Patrick, SL
Turabelidze, G
Stanek, D
Blackmore, C
Lingamfelter, D
Dudley, MH
Shadomy, SV
Shieh, WJ
Drew, CP
Batten, BC
Zaki, SR
AF Lo, Yi-Chun
Kintziger, Kristina W.
Carson, Henry J.
Patrick, Sarah L.
Turabelidze, George
Stanek, Danielle
Blackmore, Carina
Lingamfelter, Daniel
Dudley, Mary H.
Shadomy, Sean V.
Shieh, Wun-Ju
Drew, Clifton P.
Batten, Brigid C.
Zaki, Sherif R.
TI Severe Leptospirosis Similar to Pandemic (H1N1) 2009, Florida and
Missouri, USA
SO EMERGING INFECTIOUS DISEASES
LA English
DT Letter
ID OUTBREAK; PATHOLOGY; HAWAII
C1 [Lo, Yi-Chun; Patrick, Sarah L.; Turabelidze, George] Missouri Dept Hlth & Senior Serv, Jefferson City, MO 65019 USA.
[Lo, Yi-Chun; Shadomy, Sean V.; Shieh, Wun-Ju; Drew, Clifton P.; Batten, Brigid C.; Zaki, Sherif R.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Kintziger, Kristina W.; Stanek, Danielle; Blackmore, Carina] Florida Dept Hlth, Tallahassee, FL USA.
[Carson, Henry J.; Lingamfelter, Daniel; Dudley, Mary H.] Jackson Cty Med Examiners Off, Kansas City, MO USA.
RP Lo, YC (reprint author), Missouri Dept Hlth & Senior Serv, 920 Wildwood,POB 570, Jefferson City, MO 65019 USA.
EM igj7@cdc.gov
NR 10
TC 5
Z9 7
U1 0
U2 7
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD JUN
PY 2011
VL 17
IS 6
BP 1145
EP 1146
DI 10.3201/eid1706.100980
PG 2
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 772JG
UT WOS:000291229600045
PM 21749799
ER
PT J
AU Kvasnovsky, CL
Cegielski, JP
Erasmus, R
Siwisa, NO
Thomas, K
van der Walt, ML
AF Kvasnovsky, Charlotte L.
Cegielski, J. Peter
Erasmus, Roshen
Siwisa, N. Olga
Thomas, Khulile
van der Walt, Martie L.
TI Extensively Drug-Resistant TB in Eastern Cape, South Africa: High
Mortality in HIV-Negative and HIV-Positive Patients
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE extensively drug resistant; HIV; survival; treatment-related outcomes;
tuberculosis; XDR-TB
ID NEW-YORK-CITY; TUBERCULOSIS; AIDS
AB Background: Tuberculosis is a leading cause of morbidity and mortality worldwide. Patients with extensively drug-resistant tuberculosis (XDR-TB) have had high mortality rates, especially when coinfected with HIV.
Methods: A retrospective cohort study of the first 206 patients treated for XDR-TB in Eastern Cape Province, South Africa, October 2006 to January 2008, a province that has treated multidrug-resistant tuberculosis since 2000. All 206 patients were hospitalized for treatment until monthly sputum specimens were culture negative.
Results: Sixty-five patients diagnosed with XDR-TB died before XDR-TB treatment start. Among 195 patients starting treatment with a known HIV status, 108 (55.4%) were HIV positive, and 86 patients (44.1%) died during the first year of treatment. HIV-positive patients receiving antiretroviral treatment (ARVs) fared and HIV-negative patients, and more of both these groups survived than HIV-positive patients not on ARVs. However, HIV-negative patients experienced more serious adverse events requiring the withdrawal of medications than did HIV-positive patients, regardless of the use of ARVs.
Conclusions: Experience in Eastern Cape Province, South Africa, suggests that patients can be treated for both XDR-TB and HIV. We have also shown that such combination therapy can be well tolerated by patients.
C1 [Kvasnovsky, Charlotte L.] Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21201 USA.
[Kvasnovsky, Charlotte L.; van der Walt, Martie L.] Med Res Council South Africa, Pretoria, South Africa.
[Cegielski, J. Peter] US Ctr Dis Control & Prevent, Atlanta, GA USA.
[Erasmus, Roshen; Siwisa, N. Olga; Thomas, Khulile] Jose Pearson Specialized TB Hosp, Port Elizabeth, South Africa.
RP Kvasnovsky, CL (reprint author), Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21201 USA.
EM ckvasnovsky@smail.umaryland.edu
NR 16
TC 21
Z9 21
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD JUN 1
PY 2011
VL 57
IS 2
BP 146
EP 152
DI 10.1097/QAI.0b013e31821190a3
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 771MQ
UT WOS:000291163100016
PM 21297482
ER
PT J
AU Kodani, M
Yang, GY
Conklin, LM
Travis, TC
Whitney, CG
Anderson, LJ
Schrag, SJ
Taylor, TH
Beall, BW
Breiman, RF
Feikin, DR
Njenga, MK
Mayer, LW
Oberste, MS
Tondella, MLC
Winchell, JM
Lindstrom, SL
Erdman, DD
Fields, BS
AF Kodani, Maja
Yang, Genyan
Conklin, Laura M.
Travis, Tatiana C.
Whitney, Cynthia G.
Anderson, Larry J.
Schrag, Stephanie J.
Taylor, Thomas H., Jr.
Beall, Bernard W.
Breiman, Robert F.
Feikin, Daniel R.
Njenga, M. Kariuki
Mayer, Leonard W.
Oberste, M. Steven
Tondella, Maria Lucia C.
Winchell, Jonas M.
Lindstrom, Stephen L.
Erdman, Dean D.
Fields, Barry S.
TI Application of TaqMan Low-Density Arrays for Simultaneous Detection of
Multiple Respiratory Pathogens
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID REAL-TIME PCR; COMMUNITY-ACQUIRED PNEUMONIA; POLYMERASE-CHAIN-REACTION;
STREPTOCOCCUS-PNEUMONIAE; COMPREHENSIVE DETECTION; ASSAYS; VIRUSES;
PREVALENCE; INFECTION; BACTERIAL
AB The large and growing number of viral and bacterial pathogens responsible for respiratory infections poses a challenge for laboratories seeking to provide rapid and comprehensive pathogen identification. We evaluated a novel application of the TaqMan low-density array (TLDA) cards for real-time PCR detection of 21 respiratory-pathogen targets. The performance of the TLDA was compared to that of individual real-time PCR (IRTP) assays with the same primers and probes using (i) nucleic acids extracted from the 21 pathogen strains and 66 closely related viruses and bacteria and (ii) 292 clinical respiratory specimens. With spiked samples, TLDA cards were about 10-fold less sensitive than IRTP assays. By using 292 clinical specimens to generate 2,238 paired individual assays, the TLDA card exhibited 89% sensitivity (95% confidence interval [CI], 86 to 92%; range per target, 47 to 100%) and 98% specificity (95% CI, 97 to 99%; range per target, 85 to 100%) overall compared to IRTP assays as the gold standard with a threshold cycle (C(T)) cutoff of 43. The TLDA card approach offers promise for rapid and simultaneous identification of multiple respiratory pathogens for outbreak investigations and disease surveillance.
C1 [Kodani, Maja; Yang, Genyan; Conklin, Laura M.; Travis, Tatiana C.; Whitney, Cynthia G.; Schrag, Stephanie J.; Taylor, Thomas H., Jr.; Beall, Bernard W.; Mayer, Leonard W.; Tondella, Maria Lucia C.; Winchell, Jonas M.; Fields, Barry S.] Ctr Dis Control & Prevent, Div Bacterial Dis, Atlanta, GA 30333 USA.
[Anderson, Larry J.; Oberste, M. Steven; Erdman, Dean D.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA.
[Lindstrom, Stephen L.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA.
[Breiman, Robert F.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Off Director, Atlanta, GA 30333 USA.
[Njenga, M. Kariuki] Ctr Dis Control & Prevent, Div Global Dis Detect & Emergency Response, Ctr Global Hlth, Atlanta, GA 30333 USA.
[Feikin, Daniel R.] Ctr Dis Control & Prevent, Div Emerging Infect & Surveillance Serv, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA 30333 USA.
RP Kodani, M (reprint author), Ctr Dis Control & Prevent, Div Bacterial Dis, 1600 Clifton Rd,Mailstop G03, Atlanta, GA 30333 USA.
EM MKodani@cdc.gov
NR 27
TC 76
Z9 81
U1 0
U2 7
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD JUN
PY 2011
VL 49
IS 6
BP 2175
EP 2182
DI 10.1128/JCM.02270-10
PG 8
WC Microbiology
SC Microbiology
GA 769NZ
UT WOS:000291024500018
PM 21471348
ER
PT J
AU Veguilla, V
Hancock, K
Schiffer, J
Gargiullo, P
Lu, XH
Aranio, D
Branch, A
Dong, LB
Holiday, C
Liu, F
Steward-Clark, E
Sun, H
Tsang, B
Wang, D
Whaley, M
Bai, YH
Cronin, L
Browning, P
Dababneh, H
Noland, H
Thomas, L
Foster, L
Quinn, CP
Soroka, SD
Katz, JM
AF Veguilla, Vic
Hancock, Kathy
Schiffer, Jarad
Gargiullo, Paul
Lu, Xiuhua
Aranio, Darbi
Branch, Alicia
Dong, Libo
Holiday, Crystal
Liu, Feng
Steward-Clark, Evelene
Sun, Hong
Tsang, Byron
Wang, David
Whaley, Melissa
Bai, Yaohui
Cronin, Li
Browning, Peter
Dababneh, Hanan
Noland, Heather
Thomas, Leilani
Foster, Lydia
Quinn, Conrad P.
Soroka, Stephen D.
Katz, Jacqueline M.
TI Sensitivity and Specificity of Serologic Assays for Detection of Human
Infection with 2009 Pandemic H1N1 Virus in US Populations
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID INFLUENZA-A; ANTIBODY; NEUTRALIZATION; ENGLAND; SERUM
AB Swine origin 2009 H1N1 influenza virus has spread globally to cause the first influenza pandemic of the 21st century. Serological studies can improve our understanding of the extent of human infection and risk factors associated with the transmission of this pandemic virus. The "gold standard" for serodiagnosis of human influenza virus infection is the detection of seroconversion between acute-and convalescent-stage samples. However, the timing of seroepidemiological investigations often precludes the collection of truly acute-phase sera, requiring development of serological criteria for evaluating convalescent-phase sera that optimize detection of true positives and true negatives. To guide seroepidemiological investigations into the spread of the novel 2009 pandemic H1N1 virus, we characterized serum antibody responses to 2009 H1N1 virus in 87 individuals with confirmed viral infection and 227 nonexposed U. S. individuals using microneutralization (MN) and hemagglutination inhibition (HI) assays. Sensitivity and specificity were determined for each assay alone and in combination for detection of 2009 H1N1 virus-specific antibodies in convalescent-phase sera. Although the HI assay was more specific for detecting antibody to 2009 H1N1, the MN assay was more sensitive, particularly for detecting low-titer seroconversions. A combination of titers (MN >= 40 and HI >= 20) provided the highest sensitivity (90%) and specificity (96%) for individuals aged <60 years and 92% specificity for adults aged >= 60 years for detection of serologically confirmed 2009 H1N1 infections in U. S. populations during the first pandemic waves. These studies provide an approach to optimize timely serological investigations for future pandemics or outbreaks of novel influenza viruses among humans.
C1 [Veguilla, Vic; Hancock, Kathy; Gargiullo, Paul; Lu, Xiuhua; Branch, Alicia; Dong, Libo; Holiday, Crystal; Liu, Feng; Sun, Hong; Tsang, Byron; Wang, David; Bai, Yaohui; Browning, Peter; Noland, Heather; Thomas, Leilani; Foster, Lydia; Katz, Jacqueline M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Schiffer, Jarad; Aranio, Darbi; Steward-Clark, Evelene; Whaley, Melissa; Cronin, Li; Dababneh, Hanan; Quinn, Conrad P.; Soroka, Stephen D.] Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Katz, JM (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, MS G-16,1600 Clifton Rd NE, Atlanta, GA 30333 USA.
EM JKatz@cdc.gov
FU Centers for Disease Control and Prevention
FX This study was fully supported by the Centers for Disease Control and
Prevention.
NR 29
TC 53
Z9 54
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD JUN
PY 2011
VL 49
IS 6
BP 2210
EP 2215
DI 10.1128/JCM.00229-11
PG 6
WC Microbiology
SC Microbiology
GA 769NZ
UT WOS:000291024500023
PM 21471339
ER
PT J
AU Derber, C
Coudron, P
Tarr, C
Gladney, L
Turnsek, M
Shankaran, S
Wong, E
AF Derber, Catherine
Coudron, Philip
Tarr, Cheryl
Gladney, Lori
Turnsek, Maryann
Shankaran, Shivanjali
Wong, Edward
TI Vibrio furnissii: an Unusual Cause of Bacteremia and Skin Lesions after
Ingestion of Seafood
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID FLUVIALIS
AB Vibrio furnissii in the blood is rarely reported, which may explain why clinical features of bloodstream infections with this organism have not been described. We describe a patient who developed skin lesions and V. furnissii bacteremia and was successfully treated with fluoroquinolones. V. furnissii may be a serious pathogen in patients with underlying comorbidities who are exposed to seafood.
C1 [Wong, Edward] McGuire VA Med Ctr, Dept Infect Dis, Richmond, VA 23224 USA.
[Derber, Catherine; Shankaran, Shivanjali] Virginia Commonwealth Univ, Dept Med, Div Infect Dis, Richmond, VA 23298 USA.
[Tarr, Cheryl; Gladney, Lori; Turnsek, Maryann] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Wong, E (reprint author), McGuire VA Med Ctr, Dept Infect Dis, 1201 Broad Rock Blvd, Richmond, VA 23224 USA.
EM derbercj@evms.edu; Edward.wong@va.gov
NR 10
TC 5
Z9 5
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD JUN
PY 2011
VL 49
IS 6
BP 2348
EP 2349
DI 10.1128/JCM.00092-11
PG 2
WC Microbiology
SC Microbiology
GA 769NZ
UT WOS:000291024500054
PM 21450956
ER
PT J
AU Edupuganti, S
Rouphael, N
Mehta, A
Eaton, M
Heller, JG
Bressler, A
Brandt, M
O'Donnell, K
AF Edupuganti, Srilatha
Rouphael, Nadine
Mehta, Aneesh
Eaton, Molly
Heller, John G.
Bressler, Adam
Brandt, Mary
O'Donnell, Kerry
TI Fusarium falciforme Vertebral Abscess and Osteomyelitis: Case Report and
Molecular Classification
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID SOLANI SPECIES COMPLEX; DNA-SEQUENCE DATABASE; ANTIFUNGAL
SUSCEPTIBILITY; INFECTIONS; IDENTIFICATION; MANAGEMENT
AB Fusarium is a ubiquitous mold that can cause superficial infections such as keratitis and onychomycosis in immunocompetent humans; however, infections in immunocompromised hosts can be fatal. We report an unusual case of epidural abscess and vertebral osteomyelitis in a patient with an autoimmune disorder who was on long-term glucocorticoids. Multilocus DNA sequence-based typing revealed that the infection was caused by a novel three-locus haplotype of Fusarium falciforme designated FSSC 3+4qqq.
C1 [Edupuganti, Srilatha; Rouphael, Nadine; Mehta, Aneesh; Eaton, Molly] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA.
[Heller, John G.] Emory Univ, Sch Med, Dept Orthopaed Surg, Atlanta, GA USA.
[Bressler, Adam] Infect Dis Specialists Atlanta, Atlanta, GA USA.
[Brandt, Mary] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA.
[O'Donnell, Kerry] ARS, Natl Ctr Agr Utilizat Res, USDA, Peoria, IL USA.
RP Edupuganti, S (reprint author), Emory Univ, Sch Med, Div Infect Dis, Hope Clin,Emory Vaccine Ctr, 603 Church St, Decatur, GA 30030 USA.
EM sedupug@emory.edu
RI Mehta, Aneesh/B-8054-2012
OI Mehta, Aneesh/0000-0002-6552-9162
NR 21
TC 8
Z9 8
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD JUN
PY 2011
VL 49
IS 6
BP 2350
EP 2353
DI 10.1128/JCM.02547-10
PG 4
WC Microbiology
SC Microbiology
GA 769NZ
UT WOS:000291024500055
PM 21450957
ER
PT J
AU Hemashettar, BM
Patil, RN
O'Donnell, K
Chaturvedi, V
Ren, P
Padhye, AA
AF Hemashettar, B. M.
Patil, R. N.
O'Donnell, Kerry
Chaturvedi, Vishnu
Ren, Ping
Padhye, Arvind A.
TI Chronic Rhinofacial Mucormycosis Caused by Mucor irregularis (Rhizomucor
variabilis) in India
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID ZYGOMYCOSIS; SPECTRUM; DISEASE
AB In this article, we describe a chronic case of rhinofacial mucormycosis caused by Mucor irregularis, formerly known as Rhizomucor variabilis var. variabilis, a rare mycotic agent in humans. The infection caused progressive destruction of the nasal septum and soft and hard palate, leading to collapse of the nose bridge and an ulcerative gaping hole. The mucoralean mold cultured from a nasal biopsy specimen was determined by multilocus DNA sequence data to be conspecific with M. irregularis.
C1 [O'Donnell, Kerry] ARS, Bacterial Foodborne Pathogens & Mycol Res Unit, Natl Ctr Agr Utilizat Res, USDA, Peoria, IL 61604 USA.
[Hemashettar, B. M.] Hi Tech Hlth Care & Diagnost Ctr Pvt Ltd, Belgaum 590002, India.
[Patil, R. N.] Jawaharlal Nehru Med Coll, Dept Ear Nose & Throat, Belgaum 590010, India.
[Chaturvedi, Vishnu; Ren, Ping] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA.
[Padhye, Arvind A.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA.
RP O'Donnell, K (reprint author), ARS, Bacterial Foodborne Pathogens & Mycol Res Unit, Natl Ctr Agr Utilizat Res, USDA, 1815 N Univ St, Peoria, IL 61604 USA.
EM kerry.odonnell@ars.usda.gov
NR 23
TC 18
Z9 18
U1 0
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD JUN
PY 2011
VL 49
IS 6
BP 2372
EP 2375
DI 10.1128/JCM.02326-10
PG 4
WC Microbiology
SC Microbiology
GA 769NZ
UT WOS:000291024500061
PM 21508154
ER
PT J
AU Mochon, AB
Garner, OB
Hindler, JA
Krogstad, P
Ward, KW
Lewinski, MA
Rasheed, JK
Anderson, KF
Limbago, BM
Humphries, RM
AF Mochon, A. Brian
Garner, Omai B.
Hindler, Janet A.
Krogstad, Paul
Ward, Kevin W.
Lewinski, Michael A.
Rasheed, James K.
Anderson, Karen F.
Limbago, Brandi M.
Humphries, Romney M.
TI New Delhi Metallo-beta-Lactamase (NDM-1)-Producing Klebsiella
pneumoniae: Case Report and Laboratory Detection Strategies (vol 49, pg
1667, 2011)
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Correction
C1 [Mochon, A. Brian] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA.
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Pediat Infect Dis, Los Angeles, CA 90095 USA.
Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA.
RP Mochon, AB (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA.
NR 1
TC 2
Z9 2
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD JUN
PY 2011
VL 49
IS 6
BP 2386
EP 2386
DI 10.1128/JCM.00730-11
PG 1
WC Microbiology
SC Microbiology
GA 769NZ
UT WOS:000291024500069
ER
PT J
AU Kroneman, A
Vennema, H
Deforche, K
von der Avoort, H
Penaranda, S
Oberste, S
Vinje, J
Koopmans, M
AF Kroneman, A.
Vennema, H.
Deforche, K.
v. d. Avoort, H.
Penaranda, S.
Oberste, S.
Vinje, J.
Koopmans, M.
TI An automated genotyping tool for enteroviruses and noroviruses
SO JOURNAL OF CLINICAL VIROLOGY
LA English
DT Article
DE Phylogeny; Genotyping; Norovirus; Enterovirus
ID ORIGINAL CLINICAL SPECIMENS; GENOGROUP-II NOROVIRUSES; PHYLOGENETIC
ANALYSIS; PCR AMPLIFICATION; IDENTIFICATION; OUTBREAKS; GASTROENTERITIS;
SEQUENCES; VP1; SEROTYPES
AB Background: Molecular techniques are established as routine in virological laboratories and virus typing through (partial) sequence analysis is increasingly common. Quality assurance for the use of typing data requires harmonization of genotype nomenclature, and agreement on target genes, depending on the level of resolution required, and robustness of methods.
Objective: To develop and validate web-based open-access typing-tools for enteroviruses and noroviruses.
Study design: An automated web-based typing algorithm was developed, starting with BLAST analysis of the query sequence against a reference set of sequences from viruses in the family Picornaviridae or Caliciviridae. The second step is phylogenetic analysis of the query sequence and a sub-set of the reference sequences, to assign the enterovirus type or norovirus genotype and/or variant, with profile alignment, construction of phylogenetic trees and bootstrap validation. Typing is performed on VP1 sequences of Human enterovirus A to D, and ORF1 and ORF2 sequences of genogroup I and II noroviruses. For validation, we used the tools to automatically type sequences in the RIVM and CDC enterovirus databases and the FBVE norovirus database.
Results: Using the typing-tools, 785(99%) of 795 Enterovirus VP1 sequences, and 8154(98.5%) of 8342 norovirus sequences were typed in accordance with previously used methods. Subtyping into variants was achieved for 4439(78.4%) of 5838 NoV GII.4 sequences.
Discussion and conclusions: The online typing-tools reliably assign genotypes for enteroviruses and noroviruses. The use of phylogenetic methods makes these tools robust to ongoing evolution. This should facilitate standardized genotyping and nomenclature in clinical and public health laboratories, thus supporting inter-laboratory comparisons. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Kroneman, A.; Vennema, H.; v. d. Avoort, H.; Koopmans, M.] Natl Inst Publ Hlth & Environm, Infect Dis Lab, NL-3720 BA Bilthoven, Netherlands.
[Deforche, K.] MyBioData, Rotselaar, Belgium.
[Penaranda, S.; Oberste, S.; Vinje, J.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA.
[Koopmans, M.] Erasmus MC, Dept Virol, Rotterdam, Netherlands.
RP Kroneman, A (reprint author), Natl Inst Publ Hlth & Environm, Infect Dis Lab, Antonie van Leeuwenhoeklaan 9, NL-3720 BA Bilthoven, Netherlands.
EM annelies.kroneman@rivm.nl
OI Vinje, Jan/0000-0002-1530-3675
FU RIVM; CDC
FX This project was funded through core funding of the RIVM and CDC.
NR 40
TC 213
Z9 229
U1 2
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1386-6532
EI 1873-5967
J9 J CLIN VIROL
JI J. Clin. Virol.
PD JUN
PY 2011
VL 51
IS 2
BP 121
EP 125
DI 10.1016/j.jcv.2011.03.006
PG 5
WC Virology
SC Virology
GA 768OD
UT WOS:000290943600007
PM 21514213
ER
PT J
AU Painter, JE
Sales, JM
Pazol, K
Wingood, GM
Windle, M
Orenstein, WA
DiClemente, RJ
AF Painter, Julia E.
Sales, Jessica M.
Pazol, Karen
Wingood, Gina M.
Windle, Michael
Orenstein, Walter A.
DiClemente, Ralph J.
TI Adolescent Attitudes Toward Influenza Vaccination and Vaccine Uptake in
a School-Based Influenza Vaccination Intervention: A Mediation Analysis
SO JOURNAL OF SCHOOL HEALTH
LA English
DT Article
DE influenza vaccine; psychological theories; adolescent; rural population
ID UNITED-STATES; PHYSICAL-ACTIVITY; YOUNG-CHILDREN; HEALTH; VIRUS;
PREVENTION; COMMUNITY; KNOWLEDGE; IMPACT
AB BACKGROUND: School-based vaccination programs may provide an effective strategy to immunize adolescents against influenza. This study examined whether adolescent attitudes toward influenza vaccination mediated the relationship between receipt of a school-based influenza vaccination intervention and vaccine uptake.
METHODS: Participants were recruited from 2 counties participating in a school-based influenza vaccination intervention trial in rural Georgia (N = 337). Data were collected from surveys distributed to adolescents at pre- and post-intervention time points and from documents indicating vaccine uptake. Guided by the Health Belief Model and the Integrated Behavioral Model, surveys assessed demographic, behavioral, and psychosocial variables. A mediation analysis was used to test whether changes in psychosocial variables from baseline to follow-up mediated the relationship between study condition and influenza vaccine uptake.
RESULTS: Controlling for background variables, step 1 of the mediation analysis revealed a significant relationship between study condition and vaccine uptake (odds ratio = 1.77, p = .038). Step 2 of the mediation analysis revealed a significant relationship between study condition and changes in psychosocial variables from baseline to follow-up. Steps 3 and 4 of the mediation analysis revealed that there was full mediation of the relationship between study condition and receipt of an influenza vaccination by intention to receive an influenza vaccination.
CONCLUSION: Findings suggest that the success of our school-based influenza vaccination intervention in increasing vaccine uptake was mediated by adolescents' intention to receive an influenza vaccination. Future influenza vaccination efforts geared toward rural adolescents may benefit from addressing adolescent attitudes toward influenza vaccination, particularly increasing intention to receive a vaccine.
C1 [Painter, Julia E.; Sales, Jessica M.; Wingood, Gina M.; Windle, Michael] Emory Univ, Dept Behav Sci & Hlth Educ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Painter, Julia E.] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA.
[Pazol, Karen] Ctr Dis Control & Prevent, Div Reprod Hlth, Maternal & Infant Hlth Branch, Atlanta, GA 30341 USA.
[Orenstein, Walter A.] Bill & Melinda Gates Fdn, Global Hlth Program, Seattle, WA 98102 USA.
[DiClemente, Ralph J.] Emory Clin, Ctr AIDS Res, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
RP Painter, JE (reprint author), Emory Univ, Dept Behav Sci & Hlth Educ, Rollins Sch Publ Hlth, 1518 Clifton Road NE,Room 557, Atlanta, GA 30322 USA.
EM jellenb@emory.edu; jmcderm@emory.edu; kpazol@cdc.gov; gwingoo@emory.edu;
mwindle@emory.edu; walter.orenstein@gatesfoundation.org;
rdiclem@sph.emory.edu
FU NCIRD CDC HHS [R36 IP000289-01]; NIAID NIH HHS [T32AI074492]
NR 38
TC 14
Z9 14
U1 1
U2 5
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0022-4391
J9 J SCHOOL HEALTH
JI J. Sch. Health
PD JUN
PY 2011
VL 81
IS 6
BP 304
EP 312
DI 10.1111/j.1746-1561.2011.00595.x
PG 9
WC Education & Educational Research; Education, Scientific Disciplines;
Health Care Sciences & Services; Public, Environmental & Occupational
Health
SC Education & Educational Research; Health Care Sciences & Services;
Public, Environmental & Occupational Health
GA 766FE
UT WOS:000290765600003
PM 21592125
ER
PT J
AU Foti, K
Balaji, A
Shanklin, S
AF Foti, Kathryn
Balaji, Alexandra
Shanklin, Shari
TI Uses of Youth Risk Behavior Survey and School Health Profiles Data:
Applications for Improving Adolescent and School Health
SO JOURNAL OF SCHOOL HEALTH
LA English
DT Article
DE Youth Risk Behavior Survey; School Health Profiles; adolescent health;
school health; data uses
ID PROGRAM APPLICATIONS; SURVEILLANCE SYSTEM; POLICY
AB BACKGROUND: To monitor priority health risk behaviors and school health policies and practices, respectively, the Centers for Disease Control and Prevention (CDC) developed the Youth Risk Behavior Surveillance System (YRBSS) and the School Health Profiles (Profiles). CDC is often asked about the use and application of these survey data to improve adolescent and school health. The purpose of this article is to describe the importance and potential impact of Youth Risk Behavior Survey (YRBS) and Profiles data based on examples from participating sites.
METHODS: The authors spoke with representatives from 25 state and 8 local agencies funded by CDC to learn how data from the YRBS, Profiles, and other data sources are used. The authors identified common themes in the responses and categorized the responses accordingly.
RESULTS: Representatives indicated survey data are used to describe risk behaviors and school health policies and practices, inform professional development, plan and monitor programs, support health-related policies and legislation, seek funding, and garner support for future surveys. Examples presented highlight the range of possible uses of survey data.
CONCLUSIONS: State and local agencies use YRBS and Profiles data in many ways to monitor and address issues related to adolescent and school health. Innovative uses of survey data are encouraged, although it is also crucial to continue the more fundamental uses of survey data. If the data are not disseminated, the current health needs of students may not be adequately addressed.
C1 [Foti, Kathryn; Shanklin, Shari] Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA 30341 USA.
[Balaji, Alexandra] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA.
RP Foti, K (reprint author), Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, 4770 Buford Hwy NE,MS-K33, Atlanta, GA 30341 USA.
EM htk7@cdc.gov; abalaji@cdc.gov; bsa7@cdc.gov
NR 6
TC 7
Z9 7
U1 1
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0022-4391
J9 J SCHOOL HEALTH
JI J. Sch. Health
PD JUN
PY 2011
VL 81
IS 6
BP 345
EP 354
DI 10.1111/j.1746-1561.2011.00601.x
PG 10
WC Education & Educational Research; Education, Scientific Disciplines;
Health Care Sciences & Services; Public, Environmental & Occupational
Health
SC Education & Educational Research; Health Care Sciences & Services;
Public, Environmental & Occupational Health
GA 766FE
UT WOS:000290765600008
PM 21592130
ER
PT J
AU Abdel-Fattah, M
Al-Sherbiny, M
Osman, A
Charmy, R
Tsang, V
AF Abdel-Fattah, Mohamed
Al-Sherbiny, Maged
Osman, Ahmed
Charmy, Ragia
Tsang, Victor
TI Improving the detection limit of quantitative diagnosis of anti-S.
haematobium antibodies using Falcon Assay Screening Test (FAST) ELISA by
developing a new standard curve
SO PARASITOLOGY RESEARCH
LA English
DT Article
ID LINKED-IMMUNOSORBENT-ASSAY; ADULT MICROSOMAL ANTIGENS;
SCHISTOSOMA-MANSONI; SEROLOGIC REAGENT; IMMUNODIAGNOSIS; JAPONICUM;
SERODIAGNOSIS; OPTIMIZATION; INFECTIONS; COMPONENTS
AB Immunodiagnosis of schistosomiasis are currently based on parasitological examinations of stool and urine for egg detection, which is laborious and lacks sensitivity. There are many assays that detect the anti-schistosomal antibodies in patient sera. One of these assays is the Falcon assay screening test (FAST) ELISA that uses adult worm microsomal antigen for Schistosoma haematobium and Schistosoma mansoni, HAMA, MAMA antigen, respectively. This assay depends on quantitative detection of anti-schistosome antibodies, using a standard curve, but the detection limit of FAST-HAMA assay is low due to the small range of the standard curve. In our study, a new wide range (0-80 mu l/mu l) of standard curve for FAST-HAMA assay was constructed, and the cut-off value of the assay, using the new curve, was determined to be 1.2 units/mu l. Screening of 41 S. haematobium-infected sera with FAST-HAMA, using the new constructed curve, showed a sensitivity of 95%. The purity of HAMA antigen and highly specific Abs for S. haematobium lends the FAST-HAMA with the new constructed wide range standard curve as a diagnostic assay with high detection limit for S. haematobium infection.
C1 [Abdel-Fattah, Mohamed] Holding Co Biol Prod & Vaccines VACSERA, R&D Dept, Giza, Egypt.
[Al-Sherbiny, Maged; Osman, Ahmed; Charmy, Ragia] Cairo Univ, Fac Sci, Dept Zool, Giza, Egypt.
[Tsang, Victor] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Abdel-Fattah, M (reprint author), Holding Co Biol Prod & Vaccines VACSERA, R&D Dept, 51 Wezaret El Zeraa St, Giza, Egypt.
EM mafmohamed@yahoo.com
FU Ministry of Health and Population of Egypt [263-0140.2, 09-02-82];
United States Agency for International Development, Egypt
FX The research described in this article was performed under a research
grant agreement with the Schistosomiasis Research Projects, 263-0140.2,
grant # 09-02-82, funded by the Ministry of Health and Population of
Egypt and the United States Agency for International Development, Egypt.
NR 21
TC 6
Z9 8
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0932-0113
J9 PARASITOL RES
JI Parasitol. Res.
PD JUN
PY 2011
VL 108
IS 6
BP 1457
EP 1463
DI 10.1007/s00436-010-2198-y
PG 7
WC Parasitology
SC Parasitology
GA 766HR
UT WOS:000290772100016
PM 21161274
ER
PT J
AU MacNeil, JR
Cohn, AC
Zell, ER
Schmink, S
Miller, E
Clark, T
Messonnier, NE
AF MacNeil, Jessica R.
Cohn, Amanda C.
Zell, Elizabeth R.
Schmink, Susanna
Miller, Elaine
Clark, Thomas
Messonnier, Nancy E.
CA ABCs
MeningNet Surveillance Partners
TI Early Estimate of the Effectiveness of Quadrivalent Meningococcal
Conjugate Vaccine
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
DE vaccine effectiveness; conjugate vaccine; meningococcal disease
ID AGED 13-17 YEARS; HERD-IMMUNITY; UNITED-STATES; DISEASE; COVERAGE;
IDENTIFICATION; DECLINE
AB Background: In January 2005, a quadrivalent meningococcal conjugate vaccine (MenACWY D) was licensed for use in the United States. The Advisory Committee on Immunization Practices recommends MenACWY D for all adolescents 11 to 18 years of age and others at increased risk for meningococcal disease.
Methods: Reports of breakthrough meningococcal disease after vaccination with MenACWY D were collected. A simulation approach was used to estimate the expected number of cases in vaccinated persons.
Results: Between 2005 and 2008, 14 breakthrough cases, including 3 deaths occurred. At a vaccine effectiveness (VE) of 90%, 7 breakthrough cases would be expected (range, 1-17); at VE of 85%, 11 cases (range, 2-30); at VE of 80%, 15 cases (range, 5-28); and at VE of 75%, 18 cases (range, 7-32) would be expected. The probability of the >= 14 observed cases occurring was 2.9% at VE of 90%, 29.3% at VE of 85%, 66.1% at VE of 80%, and 83.0% at VE of 75%.
Conclusions: This report provides an early estimate of MenACWY D effectiveness within 3 to 4 years after vaccination, and suggests that MenACWY D effectiveness is 80% to 85%, similar to the VE reported for meningococcal polysaccharide vaccine.
C1 [MacNeil, Jessica R.; Cohn, Amanda C.; Zell, Elizabeth R.; Schmink, Susanna; Clark, Thomas; Messonnier, Nancy E.] CDC, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Miller, Elaine] CDC, Immunizat Safety Off, Atlanta, GA 30333 USA.
RP MacNeil, JR (reprint author), CDC, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS C-09, Atlanta, GA 30333 USA.
EM jmacneil@cdc.gov
NR 25
TC 30
Z9 30
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0891-3668
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD JUN
PY 2011
VL 30
IS 6
BP 451
EP 455
DI 10.1097/INF.0b013e31820a8b3c
PG 5
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA 770OB
UT WOS:000291095600004
PM 21206392
ER
PT J
AU Langley, GF
Anderson, LJ
AF Langley, Gayle Fischer
Anderson, Larry J.
TI Epidemiology and Prevention of Respiratory Syncytial Virus Infections
Among Infants and Young Children
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Review
DE respiratory syncytial virus; epidemiology; prevention
ID CONGENITAL HEART-DISEASE; INVESTIGATORS COLLABORATIVE NETWORK; CHRONIC
LUNG-DISEASE; HIGH-RISK CHILDREN; PREMATURE-INFANTS; PALIVIZUMAB
PROPHYLAXIS; COST-EFFECTIVENESS; CYSTIC-FIBROSIS; RSV INFECTION;
REQUIRING HOSPITALIZATION
AB Since its discovery in 1956, respiratory syncytial virus (RSV) has been recognized as one of the most common causes of serious lower respiratory tract infections in young children worldwide. While considered a high priority, development of a safe and effective vaccine has remained elusive. Prevention of RSV disease relies on infection control and hygiene measures, as well as providing immunoprophylaxis in select infants. The prophylaxis, however, is costly, and so targeting the recipient population and timing of administration is important for optimal effectiveness and judicious use of limited health care resources. This article reviews the epidemiology of RSV infections in infants and young children, including risk factors for severe disease, so as to inform decisions about prevention efforts.
C1 [Langley, Gayle Fischer; Anderson, Larry J.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Langley, GF (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,MS A-34, Atlanta, GA 30333 USA.
EM fez7@cdc.gov
NR 77
TC 61
Z9 63
U1 2
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0891-3668
EI 1532-0987
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD JUN
PY 2011
VL 30
IS 6
BP 510
EP 517
DI 10.1097/INF.0b013e3182184ae7
PG 8
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA 770OB
UT WOS:000291095600017
PM 21487331
ER
PT J
AU Boyle, CA
Boulet, S
Schieve, LA
Cohen, RA
Blumberg, SJ
Yeargin-Allsopp, M
Visser, S
Kogan, MD
AF Boyle, Coleen A.
Boulet, Sheree
Schieve, Laura A.
Cohen, Robin A.
Blumberg, Stephen J.
Yeargin-Allsopp, Marshalyn
Visser, Susanna
Kogan, Michael D.
TI Trends in the Prevalence of Developmental Disabilities in US Children,
1997-2008
SO PEDIATRICS
LA English
DT Article
DE developmental disabilities; prevalence; autism; attention deficit
hyperactivity disorder
ID ATTENTION-DEFICIT/HYPERACTIVITY-DISORDER; AUTISM SPECTRUM DISORDER;
UNITED-STATES; IDENTIFYING INFANTS; MENTAL-RETARDATION; HEALTH; IMPACT;
DIAGNOSIS; GIRLS
AB OBJECTIVE: To fill gaps in crucial data needed for health and educational planning, we determined the prevalence of developmental disabilities in US children and in selected populations for a recent 12-year period.
PARTICIPANTS AND METHODS: We used data on children aged 3 to 17 years from the 1997-2008 National Health Interview Surveys, which are ongoing nationally representative samples of US households. Parent-reported diagnoses of the following were included: attention deficit hyperactivity disorder; intellectual disability; cerebral palsy; autism; seizures; stuttering or stammering; moderate to profound hearing loss; blindness; learning disorders; and/or other developmental delays.
RESULTS: Boys had a higher prevalence overall and for a number of select disabilities compared with girls. Hispanic children had the lowest prevalence for a number of disabilities compared with non-Hispanic white and black children. Low income and public health insurance were associated with a higher prevalence of many disabilities. Prevalence of any developmental disability increased from 12.84% to 15.04% over 12 years. Autism, attention deficit hyperactivity disorder, and other developmental delays increased, whereas hearing loss showed a significant decline. These trends were found in all of the sociodemographic subgroups, except for autism in non-Hispanic black children.
CONCLUSIONS: Developmental disabilities are common and were reported in similar to 1 in 6 children in the United States in 2006-2008. The number of children with select developmental disabilities (autism, attention deficit hyperactivity disorder, and other developmental delays) has increased, requiring more health and education services. Additional study of the influence of risk-factor shifts, changes in acceptance, and benefits of early services is needed. Pediatrics 2011; 127:1034-1042
C1 [Boyle, Coleen A.; Boulet, Sheree; Schieve, Laura A.; Yeargin-Allsopp, Marshalyn; Visser, Susanna] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Cohen, Robin A.; Blumberg, Stephen J.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Atlanta, GA 30333 USA.
[Kogan, Michael D.] Maternal & Child Hlth Bur, US Hlth Resources & Serv Adm, Rockville, MD USA.
RP Boyle, CA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd, Atlanta, GA 30333 USA.
EM cboyle@cdc.gov
FU Centers for Disease Control and Prevention, Atlanta, Georgia
FX The National Health Interview Study is supported by the Centers for
Disease Control and Prevention, Atlanta, Georgia.
NR 39
TC 347
Z9 352
U1 21
U2 93
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD JUN
PY 2011
VL 127
IS 6
BP 1034
EP 1042
DI 10.1542/peds.2010-2989
PG 9
WC Pediatrics
SC Pediatrics
GA 771GV
UT WOS:000291146100043
PM 21606152
ER
PT J
AU Manning, SE
Davin, CA
Barfield, WD
Kotelchuck, M
Clements, K
Diop, H
Osbahr, T
Smith, LA
AF Manning, Susan E.
Davin, Carol A.
Barfield, Wanda D.
Kotelchuck, Milton
Clements, Karen
Diop, Hafsatou
Osbahr, Tracy
Smith, Lauren A.
TI Early Diagnoses of Autism Spectrum Disorders in Massachusetts Birth
Cohorts, 2001-2005
SO PEDIATRICS
LA English
DT Article
DE autism spectrum disorders; ASD; early diagnoses; early intervention
ID PERVASIVE DEVELOPMENTAL DISORDERS; INTENSIVE BEHAVIORAL TREATMENT;
PREVALENCE TRENDS; UNITED-STATES; PATERNAL AGE; CHILDREN; POPULATION;
RISK; CALIFORNIA; MINNESOTA
AB OBJECTIVE: We examined trends in autism spectrum disorder diagnoses by age 36 months (early diagnoses) and identified characteristics associated with early diagnoses.
METHODS: Massachusetts birth certificate and early-intervention program data were linked to identify infants born between 2001 and 2005 who were enrolled in early intervention and receiving autism-related services before age 36 months (through December 31, 2008). Trends in early autism spectrum disorders were examined using Cochran-Armitage trend tests. chi(2) Statistics were used to compare distributions of selected characteristics for children with and without autism spectrum disorders. Multivariate logistic regression analyses were conducted to identify independent predictors of early diagnoses.
RESULTS: A total of 3013 children (77.5 per 10 000 study population births) were enrolled in early intervention for autism spectrum disorder by age 36 months. Autism spectrum disorder incidence increased from 56 per 10 000 infants among the 2001 birth cohort to 93 per 10 000 infants in 2005. Infants of mothers younger than 24 years of age, whose primary language was not English or who were foreign-born had lower odds of an early autism spectrum disorder diagnosis. Maternal age older than 30 years was associated with increased odds of an early autism spectrum disorder diagnosis. Odds of early autism spectrum disorders were 4.5 (95% confidence interval: 4.1-5.0) times higher for boys than girls.
CONCLUSIONS: Early autism spectrum disorder diagnoses are increasing in Massachusetts, reflecting the national trend observed among older children. Linkage of early-intervention program data with population-based vital statistics is valuable for monitoring autism spectrum disorder trends and planning developmental and educational service needs. Pediatrics 2011; 127:1043-1051
C1 [Manning, Susan E.; Barfield, Wanda D.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Manning, Susan E.; Davin, Carol A.; Diop, Hafsatou; Osbahr, Tracy; Smith, Lauren A.] Bur Family Hlth & Nutr, Massachusetts Dept Publ Hlth, Boston, MA USA.
[Kotelchuck, Milton] Harvard Univ, Sch Med, Boston, MA USA.
[Clements, Karen] I3 Innovus, Medford, MA USA.
RP Manning, SE (reprint author), Ctr Dis Control & Prevent, 286 Water St,8th Floor, Augusta, ME 04333 USA.
EM aci6@cdc.gov
NR 43
TC 25
Z9 26
U1 5
U2 18
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD JUN
PY 2011
VL 127
IS 6
BP 1043
EP 1051
DI 10.1542/peds.2010-2943
PG 9
WC Pediatrics
SC Pediatrics
GA 771GV
UT WOS:000291146100044
PM 21576313
ER
PT J
AU Budnitz, DS
Salis, S
AF Budnitz, Daniel S.
Salis, Spencer
TI Preventing Medication Overdoses in Young Children: An Opportunity for
Harm Elimination
SO PEDIATRICS
LA English
DT Editorial Material
C1 [Budnitz, Daniel S.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
[Salis, Spencer] US FDA, Div New Drugs & Labeling Compliance, Off Compliance, Silver Spring, MD USA.
RP Budnitz, DS (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd NE,Mail Stop A-24, Atlanta, GA 30333 USA.
EM dbudnitz@cdc.gov
NR 11
TC 16
Z9 16
U1 0
U2 1
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD JUN
PY 2011
VL 127
IS 6
BP E1597
EP E1599
DI 10.1542/peds.2011-0926
PG 3
WC Pediatrics
SC Pediatrics
GA 771GV
UT WOS:000291146100031
PM 21555494
ER
PT J
AU Curtis, KM
Tepper, NK
Marchbanks, PA
AF Curtis, Kathryn M.
Tepper, Naomi K.
Marchbanks, Polly A.
TI Putting risk into perspective: The US medical eligibility criteria for
contraceptive use
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Contraception; Diabetes; Evidence-based guidelines; Inflammatory bowel
disease; Obesity; Risk
ID INFLAMMATORY-BOWEL-DISEASE; ORAL-CONTRACEPTIVES; DIABETES-MELLITUS;
HORMONAL CONTRACEPTION; VENOUS THROMBOEMBOLISM; UNINTENDED PREGNANCY;
UNITED-STATES; YOUNG-WOMEN; OBESITY; HEALTH
AB Unintended pregnancy remains a considerable problem in the United States, with health risks for both mother and infant. These risks may be increased among women with medical conditions, for whom pregnancy can lead to severe adverse outcomes. Highly effective and safe contraceptive methods are available to prevent unintended pregnancy. However, women with medical conditions and their providers also may be concerned about potential risks associated with contraceptive method use. Evidence-based guidance documents can be helpful tools for clinicians to efficiently use evidence and put risks into perspective. The US Medical Eligibility Criteria for Contraceptive Use, 2010, provides evidence-based recommendations for the safety of contraceptive use among women with medical conditions and other characteristics. While some contraceptive methods pose risks for some women, these must be considered in context and weighed against such considerations as the absolute risk of adverse events and the risks associated with pregnancy. Most women, even women with medical conditions, can safely use highly effective methods of contraception and promoting their use will further efforts to reduce unintended pregnancy.
C1 [Curtis, Kathryn M.; Tepper, Naomi K.; Marchbanks, Polly A.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA.
RP Curtis, KM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, MS K-34,4770 Buford Highway NE, Atlanta, GA 30341 USA.
EM kmc6@cdc.gov
NR 46
TC 5
Z9 5
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1389-9155
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD JUN
PY 2011
VL 12
IS 2
BP 119
EP 125
DI 10.1007/s11154-011-9177-1
PG 7
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 770AK
UT WOS:000291059200007
PM 21541854
ER
PT J
AU Dudeck, MA
Horan, TC
Peterson, KD
Allen-Bridson, K
Morrell, GC
Pollock, DA
Edwards, JR
AF Dudeck, Margaret A.
Horan, Teresa C.
Peterson, Kelly D.
Allen-Bridson, Katherine
Morrell, Gloria C.
Pollock, Daniel A.
Edwards, Jonathan R.
TI National Healthcare Safety Network (NHSN) report, data summary for 2009,
device-associated module
SO AMERICAN JOURNAL OF INFECTION CONTROL
LA English
DT Article
C1 [Dudeck, Margaret A.; Horan, Teresa C.; Peterson, Kelly D.; Allen-Bridson, Katherine; Morrell, Gloria C.; Pollock, Daniel A.; Edwards, Jonathan R.] Ctr Dis Control & Prevent, Natl Ctr Emerging Zoonot & Infect Dis, Publ Hlth Serv, US Dept Hlth & Human Serv,Div Healthcare Qual Pro, Atlanta, GA 30329 USA.
RP Dudeck, MA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging Zoonot & Infect Dis, Publ Hlth Serv, US Dept Hlth & Human Serv,Div Healthcare Qual Pro, MS A-24, Atlanta, GA 30329 USA.
EM MDudeck@cdc.gov
NR 14
TC 61
Z9 66
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-6553
J9 AM J INFECT CONTROL
JI Am. J. Infect. Control
PD JUN
PY 2011
VL 39
IS 5
BP 349
EP 367
DI 10.1016/j.ajic.2011.04.011
PG 19
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 769XD
UT WOS:000291050700002
PM 21774120
ER
PT J
AU Hulkower, RL
Casanova, LM
Rutala, WA
Weber, DJ
Sobsey, MD
AF Hulkower, Rachel L.
Casanova, Lisa M.
Rutala, William A.
Weber, David J.
Sobsey, Mark D.
TI Inactivation of surrogate coronaviruses on hard surfaces by health care
germicides
SO AMERICAN JOURNAL OF INFECTION CONTROL
LA English
DT Article
DE Coronavirus; disinfection; surfaces; severe acute respiratory syndrome;
SARS; environmental
ID ACUTE RESPIRATORY SYNDROME; HOSPITAL SURFACES; SARS CORONAVIRUS;
DISINFECTANTS; VIRUSES; INFECTIONS; PATHOGENS; EFFICACY; DISEASE; SPREAD
AB Background: In the 2003 severe acute respiratory syndrome outbreak, finding viral nucleic acids on hospital surfaces suggested surfaces could play a role in spread in health care environments. Surface disinfection may interrupt transmission, but few data exist on the effectiveness of health care germicides against coronaviruses on surfaces.
Methods: The efficacy of health care germicides against 2 surrogate coronaviruses, mouse hepatitis virus (MHV) and transmissible gastroenteritis virus (TGEV), was tested using the quantitative carrier method on stainless steel surfaces. Germicides were o-phenylphenol/p-tertiary amylphenol) (a phenolic), 70% ethanol, 1:100 sodium hypochlorite, ortho-phthalaldehyde (OPA), instant hand sanitizer (62% ethanol), and hand sanitizing spray (71% ethanol).
Results: After 1-minute contact time, for TGEV, there was a log(10) reduction factor of 3.2 for 70% ethanol, 2.0 for phenolic, 2.3 for OPA, 0.35 for 1:100 hypochlorite, 4.0 for 62% ethanol, and 3.5 for 71% ethanol. For MHV, log(10) reduction factors were 3.9 for 70% ethanol, 1.3 for phenolic, 1.7 for OPA, 0.62 for 1:100 hypochlorite, 2.7 for 62% ethanol, and 2.0 for 71% ethanol.
Conclusion: Only ethanol reduced infectivity of the 2 coronaviruses by >3-log(10) after 1 minute. Germicides must be chosen carefully to ensure they are effective against viruses such as severe acute respiratory syndrome coronavirus.
C1 [Casanova, Lisa M.] Georgia State Univ, Inst Publ Hlth, Atlanta, GA 30302 USA.
[Hulkower, Rachel L.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Rutala, William A.; Weber, David J.] Univ N Carolina, Dept Med, Chapel Hill, NC USA.
[Sobsey, Mark D.] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
RP Casanova, LM (reprint author), Georgia State Univ, Inst Publ Hlth, POB 3995, Atlanta, GA 30302 USA.
EM lcasanova@gsu.edu
FU Centers for Disease Control and Prevention, Atlanta, GA
FX Supported by the Centers for Disease Control and Prevention, Atlanta,
GA.
NR 31
TC 6
Z9 6
U1 3
U2 10
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-6553
J9 AM J INFECT CONTROL
JI Am. J. Infect. Control
PD JUN
PY 2011
VL 39
IS 5
BP 401
EP 407
DI 10.1016/j.ajic.2010.08.011
PG 7
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 769XD
UT WOS:000291050700008
PM 21256627
ER
PT J
AU Wright, MO
Hebden, JN
Allen-Bridson, K
Morrell, GC
Horan, T
AF Wright, Marc-Oliver
Hebden, Joan N.
Allen-Bridson, Kathy
Morrell, Gloria C.
Horan, Teresa
TI Health Care-Associated Infections Studies Project: An American Journal
of Infection Control and National Healthcare Safety Network Data Quality
Collaboration Case Study 5
SO AMERICAN JOURNAL OF INFECTION CONTROL
LA English
DT Article
C1 [Wright, Marc-Oliver] NorthShore Univ Hlth Syst, Dept Infect Control, Evanston, IL 60201 USA.
[Hebden, Joan N.] Univ Maryland, Med Ctr, Dept Infect Control, Baltimore, MD 21201 USA.
[Allen-Bridson, Kathy; Morrell, Gloria C.; Horan, Teresa] Ctr Dis Control & Prevent, Natl Healthcare Safety Network, Div Healthcare Qual Promot, Atlanta, GA USA.
RP Wright, MO (reprint author), NorthShore Univ Hlth Syst, Dept Infect Control, 2650 Ridge Ave,Burch 124, Evanston, IL 60201 USA.
EM MWright@northshore.org
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-6553
J9 AM J INFECT CONTROL
JI Am. J. Infect. Control
PD JUN
PY 2011
VL 39
IS 5
BP 431
EP 432
DI 10.1016/j.ajic.2011.03.022
PG 2
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 769XD
UT WOS:000291050700013
PM 21624636
ER
PT J
AU Luo, FJ
Florence, CS
Quispe-Agnoli, M
Ouyang, LJ
Crosby, AE
AF Luo, Feijun
Florence, Curtis S.
Quispe-Agnoli, Myriam
Ouyang, Lijing
Crosby, Alexander E.
TI Impact of Business Cycles on US Suicide Rates, 1928-2007
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID SEVERE ECONOMIC RECESSION; CRISIS HOTLINE OUTCOMES; SOUTH-KOREA;
TIME-SERIES; UNEMPLOYMENT; MORTALITY; TAIWAN; TRENDS; CALLERS; HEALTH
AB Objectives. We examined the associations of overall and age-specific suicide rates with business cycles from 1928 to 2007 in the United States.
Methods. We conducted a graphical analysis of changes in suicide rates during business cycles, used nonparametric analyses to test associations between business cycles and suicide rates, and calculated correlations between the national unemployment rate and suicide rates.
Results. Graphical analyses showed that the overall suicide rate generally rose during recessions and fell during expansions. Age-specific suicide rates responded differently to recessions and expansions. Nonparametric tests indicated that the overall suicide rate and the suicide rates of the groups aged 25 to 34 years, 35 to 44 years, 45 to 54 years, and 55 to 64 years rose during contractions and fell during expansions. Suicide rates of the groups aged 15 to 24 years, 65 to 74 years, and 75 years and older did not exhibit this behavior. Correlation results were concordant with all nonparametric results except for the group aged 65 to 74 years.
Conclusions. Business cycles may affect suicide rates, although different age groups responded differently. Our findings suggest that public health responses are a necessary component of suicide prevention during recessions. (Am J Public Health. 2011;101:1139-1146. doi:10.2105/AJPH.2010.300010)
C1 [Luo, Feijun; Florence, Curtis S.; Crosby, Alexander E.] Ctr Dis Control & Prevent, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA.
[Quispe-Agnoli, Myriam] Fed Reserve Bank Atlanta, Atlanta, GA USA.
[Ouyang, Lijing] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30341 USA.
RP Luo, FJ (reprint author), Ctr Dis Control & Prevent, Div Violence Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Hwy NE,Mailstop F-64, Atlanta, GA 30341 USA.
EM FLuo@cdc.gov
NR 57
TC 43
Z9 45
U1 2
U2 11
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD JUN
PY 2011
VL 101
IS 6
BP 1139
EP 1146
DI 10.2105/AJPH.2010.300010
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 767VQ
UT WOS:000290887000036
PM 21493938
ER
PT J
AU Feng, YY
Zhao, XK
Chen, JX
Jin, W
Zhou, XN
Li, N
Wang, L
Xiao, LH
AF Feng, Yaoyu
Zhao, Xukun
Chen, Jiaxu
Jin, Wei
Zhou, Xiaonong
Li, Na
Wang, Lin
Xiao, Lihua
TI Occurrence, Source, and Human Infection Potential of Cryptosporidium and
Giardia spp. in Source and Tap Water in Shanghai, China
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID DRINKING-WATER; MOLECULAR CHARACTERIZATION; SURFACE-WATER; WASTE-WATER;
RECREATIONAL AREAS; SOURCE TRACKING; RIVER WATER; RAW WATER; OOCYSTS;
SAMPLES
AB Genotyping studies on the source and human infection potential of Cryptosporidium oocysts in water have been almost exclusively conducted in industrialized nations. In this study, 50 source water samples and 30 tap water samples were collected in Shanghai, China, and analyzed by the U. S. Environmental Protection Agency (EPA) Method 1623. To find a cost-effective method to replace the filtration procedure, the water samples were also concentrated by calcium carbonate flocculation (CCF). Of the 50 source water samples, 32% were positive for Cryptosporidium and 18% for Giardia by Method 1623, whereas 22% were positive for Cryptosporidium and 10% for Giardia by microscopy of CCF concentrates. When CCF was combined with PCR for detection, the occurrence of Cryptosporidium (28%) was similar to that obtained by Method 1623. Genotyping of Cryptosporidium in 17 water samples identified the presence of C. andersoni in 14 water samples, C. suis in 7 water samples, C. baileyi in 2 water samples, C. meleagridis in 1 water sample, and C. hominis in 1 water sample. Therefore, farm animals, especially cattle and pigs, were the major sources of water contamination in Shanghai source water, and most oocysts found in source water in the area were not infectious to humans. Cryptosporidium oocysts were found in 2 of 30 tap water samples. The combined use of CCF for concentration and PCR for detection and genotyping provides a less expensive alternative to filtration and fluorescence microscopy for accurate assessment of Cryptosporidium contamination in water, although the results from this method are semiquantitative.
C1 [Feng, Yaoyu; Zhao, Xukun; Wang, Lin] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Sch Resource & Environm Engn, Shanghai 200237, Peoples R China.
[Chen, Jiaxu; Zhou, Xiaonong] Minist Hlth, Natl Inst Parasit Dis, Chinese Ctr Dis Control & Prevent, Key Lab Parasite & Vector Biol, Shanghai 200025, Peoples R China.
[Chen, Jiaxu; Zhou, Xiaonong] WHO Collaborating Ctr Malaria Schistosomiasis & F, Shanghai 200025, Peoples R China.
[Jin, Wei] Tongji Univ, Sch Environm Sci & Technol, Shanghai 200092, Peoples R China.
[Li, Na; Xiao, Lihua] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Feng, YY (reprint author), E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Sch Resource & Environm Engn, Shanghai 200237, Peoples R China.
EM yyfeng@ecust.edu.cn; lxiao@cdc.gov
RI Xiao, Lihua/B-1704-2013; Feng, Yaoyu/B-3076-2014
OI Xiao, Lihua/0000-0001-8532-2727;
FU National Natural Science Foundation of China [30928019, 81041078];
fundamental research funds for the Central Universities in China
[WB0914044]; Shanghai Science and Technology Committee [09540704400];
State Key Laboratory of Veterinary Etiological Biology at the Lanzhou
Veterinary Research Institute; IDEXX, China
FX This work was supported in part by the National Natural Science
Foundation of China (grants 30928019 and 81041078), by fundamental
research funds for the Central Universities in China (grant WB0914044),
by the Shanghai Science and Technology Committee (grant 09540704400), by
the State Key Laboratory of Veterinary Etiological Biology at the
Lanzhou Veterinary Research Institute, and by IDEXX, China.
NR 67
TC 33
Z9 35
U1 3
U2 28
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD JUN
PY 2011
VL 77
IS 11
BP 3609
EP 3616
DI 10.1128/AEM.00146-11
PG 8
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 767HY
UT WOS:000290847800008
PM 21498768
ER
PT J
AU Lipsitch, M
Finelli, L
Heffernan, RT
Leung, GM
Redd, SC
AF Lipsitch, Marc
Finelli, Lyn
Heffernan, Richard T.
Leung, Gabriel M.
Redd, Stephen C.
CA 2009 H1N1 Surveillance Grp
TI IMPROVING THE EVIDENCE BASE FOR DECISION MAKING DURING A PANDEMIC: THE
EXAMPLE OF 2009 INFLUENZA A/H1N1
SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE
LA English
DT Article
ID A H1N1 VIRUS; RANDOMIZED CONTROLLED-TRIAL; ACUTE RESPIRATORY SYNDROME;
NEW-YORK-CITY; UNITED-STATES; EPIDEMIC INFLUENZA; INFECTIOUS-DISEASE;
REPRODUCTION NUMBER; SERIAL INTERVAL; A(H1N1) VIRUS
AB This article synthesizes and extends discussions held during an international meeting on "Surveillance for Decision Making: The Example of 2009 Pandemic Influenza A/H1N1,'' held at the Center for Communicable Disease Dynamics (CCDD), Harvard School of Public Health, on June 14 and 15, 2010. The meeting involved local, national, and global health authorities and academics representing 7 countries on 4 continents. We define the needs for surveillance in terms of the key decisions that must be made in response to a pandemic: how large a response to mount and which control measures to implement, for whom, and when. In doing so, we specify the quantitative evidence required to make informed decisions. We then describe the sources of surveillance and other population-based data that can presently-or in the future-form the basis for such evidence, and the interpretive tools needed to process raw surveillance data. We describe other inputs to decision making besides epidemiologic and surveillance data, and we conclude with key lessons of the 2009 pandemic for designing and planning surveillance in the future.
C1 [Lipsitch, Marc] Harvard Univ, Dept Epidemiol, Dept Immunol & Infect Dis, Ctr Communicable Dis Dynam,Harvard Sch Publ Hlth, Boston, MA 02115 USA.
[Finelli, Lyn] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA.
[Redd, Stephen C.] Ctr Dis Control & Prevent, Influenza Coordinat Unit, Atlanta, GA USA.
[Heffernan, Richard T.] Bur Communicable Dis & Emergency Response, Wisconsin Div Publ Hlth, Communicable Dis Epidemiol Sect, Madison, WI USA.
[Leung, Gabriel M.] Govt Hong Kong Special Adm Reg, Hong Kong, Hong Kong, Peoples R China.
RP Lipsitch, M (reprint author), Harvard Univ, Dept Epidemiol, Dept Immunol & Infect Dis, Ctr Communicable Dis Dynam,Harvard Sch Publ Hlth, 677 Huntington Ave, Boston, MA 02115 USA.
EM mlipsitc@hsph.harvard.edu
OI Widdowson, Marc-Alain/0000-0002-0682-6933; Leung,
Gabriel/0000-0002-2503-6283; Lipsitch, Marc/0000-0003-1504-9213
FU Medical Research Council [MC_U105260556]; NIGMS NIH HHS [U54GM088558]
NR 143
TC 37
Z9 38
U1 0
U2 9
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1538-7135
J9 BIOSECUR BIOTERROR
JI Biosecur. Bioterror.
PD JUN
PY 2011
VL 9
IS 2
BP 89
EP 115
DI 10.1089/bsp.2011.0007
PG 27
WC Public, Environmental & Occupational Health; International Relations
SC Public, Environmental & Occupational Health; International Relations
GA 769JK
UT WOS:000291008500009
PM 21612363
ER
PT J
AU Adam, BW
Orsini, JJ
Martin, M
Hall, EM
Zobel, SD
Caggana, M
Hannon, WH
AF Adam, B. W.
Orsini, J. J., Jr.
Martin, M.
Hall, E. M.
Zobel, S. D.
Caggana, M.
Hannon, W. H.
TI The preparation and storage of dried-blood spot quality control
materials for lysosomal storage disease screening tests
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Lysosomal storage diseases; Newborn screening; Umbilical-cord blood;
Quality control; Dried blood spot; Storage stability; Tandem mass
spectrometry
ID TANDEM MASS-SPECTROMETRY; MUCOPOLYSACCHARIDOSIS-I; FILTER-PAPER;
ENZYMATIC DIAGNOSIS; FABRY-DISEASE; DIRECT ASSAY; DISORDERS; NEWBORNS;
ENZYMES; POMPE
AB Objective: We aimed to prepare dried-blood spot (DBS) quality control (QC) materials for lysosomal storage disease (LSD) screening tests and to determine optimum blood and DBS storage conditions.
Methods: We compared enzyme activities of five LSD markers in adult blood, umbilical-cord blood, and leukocyte-reduced blood. We measured activities in liquid blood and DBSs after predetermined intervals at controlled temperatures and humidities.
Results: Lysosomal-enzyme activity levels in umbilical-cord blood mimicked those in newborn screening samples. Lysosomal-enzyme activities in leukocyte-reduced blood were lower than in LSD-positive patient samples. Enzyme activities were stable in refrigerated liquid blood for 32 days and in frozen DBSs stored at low humidity for a year. Activity losses from DBSs after 34 days at 37 +/- 1 degrees C were 35%-66% in low humidity and 61%-100% in high humidity.
Conclusions: Umbilical-cord blood is the preferred matrix for LSD-normal DBS QC materials. Leukocyte-reduced blood is lysosomal enzyme-deficient. Failure to control humidity during DBS storage results in loss of lYsosomal-enzyme activities. Published by Elsevier Inc.
C1 [Adam, B. W.; Zobel, S. D.] Ctr Dis Control & Prevent CDC, Newborn Screening Qual Assurance Program, Atlanta, GA 30341 USA.
[Orsini, J. J., Jr.; Martin, M.; Caggana, M.] New York State Dept Hlth, Newborn Screening Program, Wadsworth Ctr, Albany, NY 12201 USA.
[Hall, E. M.] Battelle Ctr Publ Hlth Res & Evaluat, Atlanta, GA 30329 USA.
RP Adam, BW (reprint author), Ctr Dis Control & Prevent CDC, Newborn Screening Qual Assurance Program, 4770 Buford Highway NE, Atlanta, GA 30341 USA.
EM BAdam@cdc.gov
NR 24
TC 5
Z9 5
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD JUN
PY 2011
VL 44
IS 8-9
BP 704
EP 710
DI 10.1016/j.clinbiochem.2011.02.014
PG 7
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 770IY
UT WOS:000291081400025
PM 21382365
ER
PT J
AU Christenson, RH
Snyder, SR
Shaw, CS
Derzon, JH
Black, RS
Mass, D
Epner, P
Favoretto, AM
Liebow, EB
AF Christenson, Robert H.
Snyder, Susan R.
Shaw, Colleen S.
Derzon, James H.
Black, Robert S.
Mass, Diana
Epner, Paul
Favoretto, Alessandra M.
Liebow, Edward B.
TI Laboratory Medicine Best Practices: Systematic Evidence Review and
Evaluation Methods for Quality Improvement
SO CLINICAL CHEMISTRY
LA English
DT Article
ID ERRORS; PRINCIPLES; GUIDELINES; STATEMENT
AB OBJECTIVE: To develop methods for systematically reviewing evidence for identifying effective laboratory medicine (LM) practices associated with improved healthcare quality outcomes.
RELEVANCE: Although many evidence-evaluation systems have been developed, none are designed to include and rate healthcare quality improvement studies to identify evidence-based practices that improve patient safety and LM quality.
METHODS: Validated evidence-based medicine methods established by governmental agencies, the Guide to Community Preventive Services, and others were adapted for the LM field. Key methods modifications included (a) inclusion of quality improvement study designs; (b) mechanisms for inclusion of unpublished evidence, (c) combining of individual ratings of study quality, effect size, and relevance of outcome measures to evaluate consistency of practice evidence; and (d) deriving an overall strength rating to support evidence-based best practice recommendations. The methods follow the process steps of: ask; acquire; appraise; analyze; apply; and assess. Expert panels used the systematic evidence review results on practice effectiveness for improving healthcare quality outcomes consistent with the Institute of Medicine's healthcare quality aims (safe, timely, effective, equitable, efficient, and patient-centered).
CONCLUSIONS: Adapting and developing methods from validated systems and applying them to systematically review and evaluate practices in LM by using published and unpublished studies is feasible. With these methods, evidence from quality improvement studies can be systematically synthesized and summarized to identify effective LM practices. Practical and scientifically validated demonstration of a positive impact on outcomes ensures that practitioners, policy makers, and decision makers at all levels have the evidence needed for improving healthcare quality and public health. (C) 2011 American Association for Clinical Chemistry
C1 [Christenson, Robert H.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
[Snyder, Susan R.; Shaw, Colleen S.] Ctr Dis Control & Prevent, Lab Res & Evaluat Branch, Div Lab Sci & Stand, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA USA.
[Derzon, James H.; Black, Robert S.; Favoretto, Alessandra M.; Liebow, Edward B.] Battelle Ctr Publ Hlth Res & Evaluat, Seattle, WA USA.
[Mass, Diana] Arizona State Univ, Sch Life Sci, Clin Sci Lab, Tempe, AZ USA.
[Epner, Paul] Paul Epner LLC, Evanston, IL USA.
RP Christenson, RH (reprint author), Univ Maryland, Sch Med, 22 S Greene St, Baltimore, MD 21201 USA.
EM rchristenson@umm.edu
RI Derzon, James/D-7220-2013
OI Liebow, Edward/0000-0002-1101-629X; Derzon, James/0000-0002-3997-1950
FU CDC [W911NF-07-D-0001/DO 0191/TCN 07235]
FX CDC (W911NF-07-D-0001/DO 0191/TCN 07235) to Battelle Centers for Public
Health Research and Evaluation.
NR 34
TC 22
Z9 22
U1 1
U2 5
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
J9 CLIN CHEM
JI Clin. Chem.
PD JUN
PY 2011
VL 57
IS 6
BP 816
EP 825
DI 10.1373/clinchem.2010.157131
PG 10
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA 769PF
UT WOS:000291028600009
PM 21515742
ER
PT J
AU Goins, RT
Spencer, SM
McGuire, LC
Goldberg, J
Wen, Y
Henderson, JA
AF Goins, R. Turner
Spencer, S. Melinda
McGuire, Lisa C.
Goldberg, Jack
Wen, Yang
Henderson, Jeffrey A.
TI Adult Caregiving Among American Indians: The Role of Cultural Factors
SO GERONTOLOGIST
LA English
DT Article
DE Cultural identity; Traditional healing; Sociocultural stress; Coping
model
ID FAMILY CAREGIVERS; AFRICAN-AMERICAN; ETHNIC-IDENTITY; SOCIOCULTURAL
STRESS; PHYSICAL HEALTH; ALASKA-NATIVES; MENTAL-HEALTH; COPING MODEL;
DEMENTIA; BURDEN
AB Purpose: With a sample of American Indian adults, we estimated the prevalence of adult caregiving, assessed the demographic and cultural profile of caregivers, and examined the association between cultural factors and being a caregiver. This is the first such study conducted with American Indians. Design and Methods: Data came from a cross-sectional study of 5,207 American Indian adults residing on 2 closely related Lakota Sioux reservations in the Northern Plains and one American Indian community in the Southwest. Cultural factors included measures of cultural identity and traditional healing practices. Results: Seventeen percent of our sample reported being caregivers. In both the Northern Plains and Southwest, caregiving was positively correlated with younger age, being a woman, larger household size, attending and participating in Native events, and endorsement of traditional healing practices. In both regions, attendance and participation in Native events and engagement in traditional healing practices were associated with increased odds of caregiving after adjusting for covariates. Only in the Northern Plains did we find that speaking some Native language at home was associated with increased odds of being a caregiver. Examination of interaction terms indicated some sex differences in the association between cultural factors and caregiving in the Northern Plains but not in the Southwest. Implications: Our findings indicate that greater cultural identity and engagement in traditional healing practices are related to caregiving in American Indian populations. Caregiving research, intervention efforts, and caregiving programs and services in Native communities should pay special attention to the dynamics of culture and caregiving.
C1 [Goins, R. Turner] W Virginia Univ, Ctr Aging, Dept Community Med, Morgantown, WV 26506 USA.
[Spencer, S. Melinda] Univ S Carolina, Dept Hlth Promot Educ & Behav, Columbia, SC 29208 USA.
[Spencer, S. Melinda] Univ S Carolina, Inst So Studies, Columbia, SC 29208 USA.
[McGuire, Lisa C.] Ctr Dis Control & Prevent, Div Injury Response, Atlanta, GA USA.
[Goldberg, Jack] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
[Goldberg, Jack] VA Epidemiol Res & Informat Ctr, Vietnam Era Twin Registry, Seattle, WA USA.
[Wen, Yang; Henderson, Jeffrey A.] Black Hills Ctr Amer Indian Hlth, Rapid City, SD USA.
RP Goins, RT (reprint author), W Virginia Univ, Ctr Aging, Dept Community Med, Morgantown, WV 26506 USA.
EM rgoins@hsc.wvu.edu
FU NCCDPHP CDC HHS [U48 DP000052]; NCI NIH HHS [R01 CA089139, 1R01 CA89139]
NR 54
TC 9
Z9 9
U1 1
U2 18
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0016-9013
J9 GERONTOLOGIST
JI Gerontologist
PD JUN
PY 2011
VL 51
IS 3
BP 310
EP 320
DI 10.1093/geront/gnq101
PG 11
WC Gerontology
SC Geriatrics & Gerontology
GA 766XO
UT WOS:000290820100004
PM 21148253
ER
PT J
AU Moloney, M
Aycock, D
Cotsonis, G
Myerburg, S
Farino, C
Lentz, M
Johnson, C
AF Moloney, M.
Aycock, D.
Cotsonis, G.
Myerburg, S.
Farino, C.
Lentz, M.
Johnson, C.
TI Women's Symptoms, Triggers, and Migraine Predictions in an
Internet-Based Diary Study
SO HEADACHE
LA English
DT Meeting Abstract
CT 53rd Annual Scientific Meeting on American-Headache-Society
CY JUN 02-05, 2011
CL Washington, DC
SP Amer Headache Soc
C1 [Moloney, M.; Aycock, D.] Georgia State Univ, Byrdine F Lewis Sch Nursing, Atlanta, GA 30303 USA.
[Cotsonis, G.; Farino, C.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Myerburg, S.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Lentz, M.] Univ Washington, Sch Nursing, Seattle, WA 98195 USA.
[Johnson, C.] Vanderbilt Univ, Sch Med, Dept Neurol, Nashville, TN 37212 USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0017-8748
J9 HEADACHE
JI Headache
PD JUN
PY 2011
VL 51
SU 1
BP 18
EP 18
PG 1
WC Clinical Neurology
SC Neurosciences & Neurology
GA 768WJ
UT WOS:000290969100045
ER
PT J
AU Ogbuanu, IU
AF Ogbuanu, I. U.
TI Tracking Progress Toward Global Polio Eradication-Worldwide, 2009-2010
(Reprinted from MMWR, vol 60, pg 441-445, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Ogbuanu, I. U.] CDC, Div Viral Dis, Global Immunizat Div, Natl Ctr Immunizat & Resp Dis,EIS, Atlanta, GA 30333 USA.
WHO, Polio Eradicat Dept, CH-1211 Geneva, Switzerland.
RP Ogbuanu, IU (reprint author), CDC, Div Viral Dis, Global Immunizat Div, Natl Ctr Immunizat & Resp Dis,EIS, Atlanta, GA 30333 USA.
EM ige2@cdc.gov
NR 1
TC 1
Z9 1
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 1
PY 2011
VL 305
IS 21
BP 2165
EP 2167
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 770RN
UT WOS:000291106300009
ER
PT J
AU Tynan, M
Babb, S
MacNeil, A
Griffin, M
AF Tynan, M.
Babb, S.
MacNeil, A.
Griffin, M.
TI State Smoke-Free Laws for Worksites, Restaurants, and Bars-United
States, 2000-2010 (Reprinted from MMWR, vol 60, pg 472-475, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
ID ASTHMA
C1 [Tynan, M.; Babb, S.; MacNeil, A.; Griffin, M.] CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
RP Tynan, M (reprint author), CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
EM mtynan@cdc.gov
NR 11
TC 1
Z9 1
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 1
PY 2011
VL 305
IS 21
BP 2167
EP 2169
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 770RN
UT WOS:000291106300010
ER
PT J
AU Kent, M
Platt, SR
Rech, RR
Eagleson, JS
Howerth, EW
Shoff, M
Fuerst, PA
Booton, G
Visvesvara, GS
Schatzberg, SJ
AF Kent, Marc
Platt, Simon R.
Rech, Raquel R.
Eagleson, Joseph S.
Howerth, Elizabeth W.
Shoff, Megan
Fuerst, Paul A.
Booton, Greg
Visvesvara, Govihda S.
Schatzberg, Scott J.
TI Multisystemic infection with an Acanthamoeba sp in a dog
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Article
ID RESPONSIVE MENINGITIS-ARTERITIS; REAL-TIME PCR; PRIMARY AMEBIC
MENINGOENCEPHALITIS; URINARY-TRACT-INFECTION; FREE-LIVING AMEBAS;
NAEGLERIA-FOWLERI; LONG-TERM; BALAMUTHIA-MANDRILLARIS; OPPORTUNISTIC
AMEBAS; KERATITIS
AB Case Description-A 10-month-old Boxer was evaluated for fever and signs of cervical pain.
Clinical Findings-Physical examination revealed lethargy, fever, and mucopurulent ocular and preputial discharge. On neurologic examination, the gait was characterized by a short stride. The dog kept its head flexed and resisted movement of the neck, consistent with cervical pain. Clinicopathblogic findings included neutrophilic leukocytosis, a left shift, and monocytosis. Cervical radiographs were unremarkable. Cerebrospinal fluid analysis revealed neutrophilic pleocytosis and high total protein content. On the basis of signalment, history, and clinicopathologic data, a diagnosis of steroid-responsive meningitis-arteritis was made.
Treatment and Outcome-The dog was treated with prednisone (3.2 mg/kg [1.45 mg/lb], PO, q 24 h), for 3 weeks with limited response. Consequently, azathioprine (2 mg/kg [0.9 mg/lb], PO, q 24 h) was administered. Three weeks later, the dog was evaluated for tachypnea and lethargy. Complete blood count revealed leukopenia, neutropenia, and a left shift. Thoracic radiography revealed a diffuse bronchointerstitial pattern. The dog subsequently went into respiratory arrest and died. On histologic evaluation, amoebic organisms were observed in the lungs, kidneys, and meninges of the brain and spinal cord. A unique Acanthamoeba sp was identified by use of PCR assay.
Clinical Relevance-This dog developed systemic amoebic infection presumed to be secondary to immunosuppression. The development of secondary infection should be considered in animals undergoing immunosuppression for immune-mediated disease that develop clinical signs unrelated to the primary disease. Although uncommon, amoebic infection may develop in immunosuppressed animals. Use of a PCR assay for identification of Acanthamoeba spp may provide an antemortem diagnosis. (J Am Vet Med Assoc 2011;238:1476-1481)
C1 [Kent, Marc; Platt, Simon R.; Eagleson, Joseph S.; Schatzberg, Scott J.] Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg, Athens, GA 30602 USA.
[Rech, Raquel R.; Howerth, Elizabeth W.] Univ Georgia, Coll Vet Med, Dept Pathol, Athens, GA 30602 USA.
[Shoff, Megan] US FDA, Ctr Devices & Radiol Hlth, Off Sci & Engn Labs, Div Biol, Silver Spring, MD 20993 USA.
[Fuerst, Paul A.] Ohio State Univ, Dept Evolut Ecol & Organismal Biol, Coll Biol Sci, Columbus, OH 43210 USA.
[Booton, Greg] Ohio State Univ, Dept Mol Genet, Coll Biol Sci, Columbus, OH 43210 USA.
[Visvesvara, Govihda S.] CDC, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA.
RP Kent, M (reprint author), Univ Georgia, Coll Vet Med, Dept Small Anim Med & Surg, Athens, GA 30602 USA.
EM Mkent1@uga.edu
NR 41
TC 10
Z9 10
U1 0
U2 0
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD JUN 1
PY 2011
VL 238
IS 11
BP 1476
EP 1481
PG 6
WC Veterinary Sciences
SC Veterinary Sciences
GA 770GR
UT WOS:000291075500019
PM 21627512
ER
PT J
AU Ethier, KA
Dittus, PJ
DeRosa, CJ
Chung, EQ
Martinez, E
Kerndt, PR
AF Ethier, Kathleen A.
Dittus, Patricia J.
DeRosa, Christine J.
Chung, Emily Q.
Martinez, Esteban
Kerndt, Peter R.
TI School-Based Health Center Access, Reproductive Health Care, and
Contraceptive Use Among Sexually Experienced High School Students
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Article
DE Adolescent sexual health; Contraceptive use; Reproductive health care;
School-based health centers
ID CLINICS; SERVICES; BEHAVIOR; IMPACT
AB Purpose: The current analyses compared receipt of reproductive health care, contraceptive use, and screening for sexually transmitted diseases (STD) among adolescents who are sexually experienced, with or without access to a school clinic.
Methods: A total of 12 urban California high schools, selected from areas with high teen pregnancy and STD rates, half with school-based health centers (SBHCs), participated in an intervention study designed to improve sexual health among adolescents. Of the participating students, 44% indicated that they had ever had intercourse and were included in these analyses.
Results: Access to an SBHC did not influence receipt of reproductive health care for either males or females and did not influence contraceptive use, either hormonal or condoms, for males. For females, however, those with access to an SBHC had increased odds of having received pregnancy or disease prevention care (adjusted odds ratio [AOR] = 1.45, 95% confidence interval [CI] = 1.16-1.80), having used hormonal contraceptives at last sex (AOR = 1.68, 95% CI = 1.24-2.28), and were more likely to have ever been screened for an STD (AOR = 1.85, 95% CI = 1.43-2.40). Also among female students, those with access to an SBHC were more likely to have used emergency contraception at last sex (AOR = 2.1, 95% CI = 1.08-4.22).
Conclusion: Although access to an on-site clinic does not seem to lead to increases in all types of reproductive care in the population as a whole, sexually active females are more likely to have received more specific care and to have used hormonal contraceptives if their school has an SBHC. Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine.
C1 [Ethier, Kathleen A.; Dittus, Patricia J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[DeRosa, Christine J.; Chung, Emily Q.; Martinez, Esteban] Hlth Res Assoc, Los Angeles, CA USA.
[Kerndt, Peter R.] Sexually Transmitted Dis Program, Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA.
RP Ethier, KA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS D-37, Atlanta, GA 30333 USA.
EM kbe0@cdc.gov
FU Centers for Disease Control and Prevention [U30/CCU922283-01]
FX This research was supported by the Centers for Disease Control and
Prevention (U30/CCU922283-01). The findings and conclusions in this
article are those of the authors and do not necessarily represent the
views of the CDC.
NR 11
TC 27
Z9 28
U1 2
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1054-139X
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD JUN
PY 2011
VL 48
IS 6
BP 562
EP 565
DI 10.1016/j.jadohealth.2011.01.018
PG 4
WC Psychology, Developmental; Public, Environmental & Occupational Health;
Pediatrics
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA 763OG
UT WOS:000290568700004
PM 21575814
ER
PT J
AU Van Vliet, G
Grosse, SD
AF Van Vliet, Guy
Grosse, Scott D.
TI The Continuing Health Burden of Congenital Hypothyroidism in the Era of
Neonatal Screening
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Editorial Material
ID YOUNG-ADULTS; CHILDREN; OUTCOMES
C1 [Van Vliet, Guy] Univ Montreal, Hop St Justine, Dept Endocrinol Serv, Serv Endocrinol, Montreal, PQ H3T 1C5, Canada.
[Van Vliet, Guy] Univ Montreal, Hop St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada.
Univ Montreal, Dept Pediat, Montreal, PQ H3T 1C5, Canada.
[Grosse, Scott D.] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
RP Van Vliet, G (reprint author), Univ Montreal, Hop St Justine, Dept Endocrinol Serv, Serv Endocrinol, 3175 Cote St Catherine, Montreal, PQ H3T 1C5, Canada.
EM guy.van-vliet@recherche-ste-justine.qc.ca
NR 21
TC 4
Z9 4
U1 0
U2 1
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUN
PY 2011
VL 96
IS 6
BP 1671
EP 1673
DI 10.1210/jc.2011-0687
PG 3
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 766TU
UT WOS:000290810200039
PM 21602460
ER
PT J
AU Mei, ZG
Cogswell, ME
Looker, AC
Pfeiffer, CM
Cusick, SE
Lacher, DA
Grummer-Strawn, LM
AF Mei, Zuguo
Cogswell, Mary E.
Looker, Anne C.
Pfeiffer, Christine M.
Cusick, Sarah E.
Lacher, David A.
Grummer-Strawn, Laurence M.
TI Assessment of iron status in US pregnant women from the National Health
and Nutrition Examination Survey (NHANES), 1999-2006
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID SERUM TRANSFERRIN RECEPTOR; RANDOMIZED CONTROLLED-TRIAL; UNITED-STATES;
DEFICIENCY ANEMIA; REFERENCE RANGES; BODY IRON; AGE; SUPPLEMENTATION;
POPULATION; PREVALENCE
AB Background: Total body iron calculated from serum ferritin and soluble transferrin receptor concentrations allows for the evaluation of the full range of iron status.
Objective: We described the distribution of total body iron and the prevalence of iron deficiency (ID) on the basis of total body iron in US pregnant women.
Design: We examined data from the National Health and Nutrition Examination Survey (NHANES) in 1999-2006 for 1171 pregnant women.
Results: ID prevalence (+/- SE) in US pregnant women, which was defined as total body iron <0 mg/kg, was 18.0 +/- 1.4%. Pregnant women in the first trimester had a higher mean total body iron than did pregnant women in the second or third trimesters. ID prevalence in pregnant women increased significantly with each trimester (6.9 +/- 2.2%, 14.3 +/- 2.1%, and 29.5 +/- 2.7% in the first, second, and third trimesters, respectively). Pregnant women with parity >= 2 had the lowest mean total body iron and the highest prevalence of ID compared with values for pregnant women with parity of 0 or 1. The ID prevalence in non-Hispanic white pregnant women was significantly lower than in Mexican American or non-Hispanic black pregnant women. The mean total body iron and the prevalence of ID did not differ by educational level or by family income.
Conclusions: To our knowledge, these are the first data on total body iron distributions for a representative sample of US pregnant women. Low total body iron is more prevalent in pregnant women in the second or third trimesters, in Mexican American pregnant women, in non-Hispanic black pregnant women, and in women with parity >= 2. Am J Clin Nutr 2011;93:1312-20.
C1 [Mei, Zuguo; Grummer-Strawn, Laurence M.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Cogswell, Mary E.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30341 USA.
[Pfeiffer, Christine M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Looker, Anne C.; Lacher, David A.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
[Cusick, Sarah E.] Univ Minnesota, Div Global Pediat, Minneapolis, MN USA.
RP Mei, ZG (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Mailstop K-25,4770 Buford Highway, Atlanta, GA 30341 USA.
EM zmei@cdc.gov
NR 36
TC 54
Z9 56
U1 1
U2 8
PU AMER SOC CLINICAL NUTRITION
PI BETHESDA
PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998
USA
SN 0002-9165
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JUN
PY 2011
VL 93
IS 6
BP 1312
EP 1320
DI 10.3945/ajcn.110.007195
PG 9
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 766PD
UT WOS:000290796700019
PM 21430118
ER
PT J
AU Crider, KS
Zhu, JH
Hao, L
Yang, QH
Yang, TP
Gindler, J
Maneval, DR
Quinlivan, EP
Li, Z
Bailey, LB
Berry, RJ
AF Crider, Krista S.
Zhu, Jiang-Hui
Hao, Ling
Yang, Quan-He
Yang, Thomas P.
Gindler, Jacqueline
Maneval, David R.
Quinlivan, Eoin P.
Li, Zhu
Bailey, Lynn B.
Berry, Robert J.
TI MTHFR 677C -> T genotype is associated with folate and homocysteine
concentrations in a large, population-based, double-blind trial of folic
acid supplementation
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID NEURAL-TUBE DEFECTS; METHYLENETETRAHYDROFOLATE REDUCTASE; POLYMORPHISMS;
RISK; WOMEN; GENE; FORTIFICATION; PREVALENCE; METABOLISM; PREVENTION
AB Background: The methylenetetrahydrofolate reductase (MTHFR) genotype is associated with modification of disease and risk of neural tube defects. Plasma and red blood cell (RBC) folate and plasma homocysteine concentrations change in response to daily intakes of folic acid supplements, but no large-scale or population-based randomized trials have examined whether the MTHFR genotype modifies the observed response.
Objective: We sought to determine whether the MTHFR 677C -> T genotype modifies the response to folic acid supplementation during and 3 mo after discontinuation of supplementation.
Design: Northern Chinese women of childbearing age were enrolled in a 6-mo supplementation trial of different folic acid doses: 100, 400, and 4000 mu g/d and 4000 mu g/wk. Plasma and RBC folate and plasma homocysteine concentrations were measured at baseline; after 1, 3, and 6 mo of supplementation; and 3 mo after discontinuation of supplementation. MTHFR genotyping was performed to identify a C -> T mutation at position 677 (n = 932).
Results: Plasma and RBC folate and homocysteine concentrations were associated with MTHFR genotype throughout the supplementation trial, regardless of folic acid dose. MTHFR TT was associated with lower folate concentrations, and the trend of TT < CC was maintained at even the highest doses. Folic acid doses of 100 mu g/d or 4000 mu g/wk did not reduce high homocysteine concentrations in those with the MTHFR TT genotype.
Conclusion: MTHFR genotype was an independent predictor of plasma and RBC folate and plasma homocysteine concentrations and did not have a significant interaction with folic acid dose during supplementation. This trial was registered at clinicaltrials.gov as NCT00207558. Am J Clin Nutr 2011;93:1365-72.
C1 [Crider, Krista S.; Yang, Quan-He; Gindler, Jacqueline; Berry, Robert J.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Zhu, Jiang-Hui; Hao, Ling; Li, Zhu] Peking Univ, Hlth Sci Ctr, Natl Ctr Maternal & Infant Hlth, Beijing 100871, Peoples R China.
[Zhu, Jiang-Hui; Hao, Ling; Li, Zhu] Peking Univ, Minist Hlth, Natl Reference Lab Reprod & Child Hlth, Beijing 100871, Peoples R China.
[Yang, Thomas P.] Univ Florida, Dept Biochem & Mol Biol, Ctr Epigenet, Gainesville, FL 32610 USA.
[Maneval, David R.; Quinlivan, Eoin P.; Bailey, Lynn B.] Univ Florida, Dept Food Sci & Human Nutr, Gainesville, FL 32611 USA.
RP Berry, RJ (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA.
EM rjb1@cdc.gov
OI Berry, Robert/0000-0002-7162-5046
FU Centers for Disease Control and Prevention
FX Supported by a cooperative agreement with the Centers for Disease
Control and Prevention.
NR 32
TC 49
Z9 52
U1 1
U2 10
PU AMER SOC CLINICAL NUTRITION
PI BETHESDA
PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998
USA
SN 0002-9165
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JUN
PY 2011
VL 93
IS 6
BP 1365
EP 1372
DI 10.3945/ajcn.110.004671
PG 8
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 766PD
UT WOS:000290796700026
PM 21508090
ER
PT J
AU Kahn, HS
Pavkov, ME
AF Kahn, Henry S.
Pavkov, Meda E.
TI Intra-abdominal Pressure Can Be Estimated Inexpensively by the Sagittal
Abdominal Diameter
SO AMERICAN JOURNAL OF KIDNEY DISEASES
LA English
DT Letter
ID COMPARTMENT SYNDROME; OBESITY; HYPERTENSION
C1 [Kahn, Henry S.; Pavkov, Meda E.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
RP Kahn, HS (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
OI Kahn, Henry/0000-0003-2533-1562
NR 5
TC 2
Z9 2
U1 1
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0272-6386
J9 AM J KIDNEY DIS
JI Am. J. Kidney Dis.
PD JUN
PY 2011
VL 57
IS 6
BP 959
EP 959
DI 10.1053/j.ajkd.2011.03.007
PG 1
WC Urology & Nephrology
SC Urology & Nephrology
GA 766MX
UT WOS:000290788400023
PM 21601129
ER
PT J
AU Hibbs, AC
Secor, WE
Van Gerven, D
Armelagos, G
AF Hibbs, Amber Campbell
Secor, W. Evan
Van Gerven, Dennis
Armelagos, George
TI Irrigation and Infection: The Immunoepidemiology of Schistosomiasis in
Ancient Nubia
SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
LA English
DT Article
DE paleoepidemiology; Schistosoma mansoni; parasite ecology
ID CIRCULATING CATHODIC ANTIGEN; MANSONI PREVALENCES; EPIDEMIOLOGY; KENYA;
HAEMATOBIUM; MORBIDITY; EGYPT; TRANSMISSION; METAANALYSIS; POPULATIONS
AB Schistosomiasis has been deemed "the most important water-based disease from a global public-health perspective'' in modern populations. To better understand the burden of schistosomiasis in ancient populations, we conducted immunologic examinations of desiccated tissue samples from two ancient Nubian populations, Wadi Halfa (N = 46) and Kulubnarti (N = 191). Saqia irrigated agriculture increases the available habitat for the aquatic vector snails and the risk of exposure. On the basis of evidence regarding the impact of saqia irrigation on schistosomiasis prevalence and transmission in modern populations, we predicted that the prevalence of Schistosoma mansoni infection would be higher in Wadi Halfa (saqia irrigation) than Kulubnarti (annual flooding). We also predicted that peak infection prevalence would occur at an earlier age within the Wadi Halfa population than the Kulubnarti population and that in both populations the prevalence of schistosomiasis would be higher in males than females due to differential water contact. The prevalence of S. mansoni was greater in the Wadi Halfa population (26.1%) than at Kulubnarti (9.4%) (P = 0.002). However, peak prevalence of infection did not occur in a younger age category within the Wadi Halfa population; prevalence of infection peaked at 66.7% in the mature adult age group (46+1 years) in the Wadi Halfa population and at 16% in the later child age group (6-10 years) in the Kulubnarti population. There were no statistically significant differences in prevalence between males and females of either population. The impact of human alteration of the environment on the transmission of schistosomiasis is clearly shown in these populations. Am J Phys Anthropol 145:290-298, 2011. (C) 2011 Wiley-Liss, Inc.
C1 [Hibbs, Amber Campbell; Armelagos, George] Emory Univ, Dept Anthropol, Atlanta, GA 30322 USA.
[Secor, W. Evan] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA.
[Van Gerven, Dennis] Univ Colorado, Dept Anthropol, Boulder, CO 80309 USA.
RP Hibbs, AC (reprint author), Emory Univ, Dept Anthropol, 207 Anthropol,1557 Dickey Dr, Atlanta, GA 30322 USA.
EM amber.rae.campbell@gmail.com
NR 63
TC 5
Z9 5
U1 2
U2 21
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0002-9483
J9 AM J PHYS ANTHROPOL
JI Am. J. Phys. Anthropol.
PD JUN
PY 2011
VL 145
IS 2
BP 290
EP 298
DI 10.1002/ajpa.21493
PG 9
WC Anthropology; Evolutionary Biology
SC Anthropology; Evolutionary Biology
GA 766HQ
UT WOS:000290772000011
PM 21469072
ER
PT J
AU Govender, NP
Patel, J
van Wyk, M
Chiller, TM
Lockhart, SR
AF Govender, Nelesh P.
Patel, Jaymati
van Wyk, Marelize
Chiller, Tom M.
Lockhart, Shawn R.
CA Grp Enteric Resp Meningeal Dis
TI Trends in Antifungal Drug Susceptibility of Cryptococcus neoformans
Isolates Obtained through Population-Based Surveillance in South Africa
in 2002-2003 and 2007-2008
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID HIV-INFECTED PATIENTS; FLUCONAZOLE PROPHYLAXIS; ANTIRETROVIRAL THERAPY;
IMMUNE RECONSTITUTION; SYMPTOMATIC RELAPSE; AMPHOTERICIN-B; MENINGITIS;
RESISTANCE; AIDS; MICRODILUTION
AB Cryptococcus neoformans is the most common cause of meningitis among adult South Africans with HIV infection/AIDS. Widespread use of fluconazole for treatment of cryptococcal meningitis and other HIV-associated opportunistic fungal infections in South Africa may lead to the emergence of isolates with reduced fluconazole susceptibility. MIC testing using a reference broth microdilution method was used to determine if isolates with reduced susceptibility to fluconazole or amphotericin B had emerged among cases of incident disease. Incident isolates were tested from two surveillance periods (2002-2003 and 2007-2008) when population-based surveillance was conducted in Gauteng Province, South Africa. These isolates were also tested for susceptibility to flucytosine, itraconazole, voriconazole, and posaconazole. Serially collected isolate pairs from cases at several large South African hospitals were also tested for susceptibility to fluconazole. Of the 487 incident isolates tested, only 3 (0.6%) demonstrated a fluconazole MIC of >= 16 mu g/ml; all of these isolates were from 2002-2003. All incident isolates were inhibited by very low concentrations of amphotericin B and exhibited very low MICs to voriconazole and posaconazole. Of 67 cases with serially collected isolate pairs, only 1 case was detected where the isolate collected more than 30 days later had a fluconazole MIC value significantly higher than the MIC of the corresponding incident isolate. Although routine antifungal susceptibility testing of incident isolates is not currently recommended in clinical settings, it is still clearly important for public health to periodically monitor for the emergence of resistance.
C1 [Govender, Nelesh P.; Patel, Jaymati; van Wyk, Marelize] Natl Inst Communicable Dis, Mycol Reference Unit, Johannesburg, South Africa.
[Govender, Nelesh P.] Univ Witwatersrand, Fac Hlth Sci, Johannesburg, South Africa.
[Chiller, Tom M.; Lockhart, Shawn R.] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA.
RP Govender, NP (reprint author), Natl Inst Communicable Dis, Mycol Reference Unit, Private Bag X4, ZA-2131 Johannesburg, South Africa.
EM neleshg@nicd.ac.za
FU Pfizer South Africa; National Health Laboratory Service; CDC, Atlanta,
GA [U60/CCU022088]; United States Agency for International Development's
Antimicrobial Resistance Initiative; CDC; National Center for HIV/AIDS;
Viral Hepatitis; STD; TB Prevention (NCHHSTP); Global AIDS Program (GAP)
[U62/PSO022901]
FX Nelesh P. Govender is the recipient of a research grant from Pfizer
South Africa.; From 2002 through 2004, this study was funded through a
cooperative agreement between the National Health Laboratory Service and
the CDC, Atlanta, GA. From 2005 through 2006, the study was partially
funded by the United States Agency for International Development's
Antimicrobial Resistance Initiative, transferred via cooperative
agreement U60/CCU022088 from the CDC, Atlanta, GA. From 2005 through
2008, the study was also partially supported by CDC, National Center for
HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Global AIDS
Program (GAP), cooperative agreement U62/PSO022901.
NR 39
TC 23
Z9 23
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD JUN
PY 2011
VL 55
IS 6
BP 2606
EP 2611
DI 10.1128/AAC.00048-11
PG 6
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 765NA
UT WOS:000290713400017
PM 21444707
ER
PT J
AU Verret, WJ
Arinaitwe, E
Wanzira, H
Bigira, V
Kakuru, A
Kamya, M
Tappero, JW
Sandison, T
Dorsey, G
AF Verret, Wendy J.
Arinaitwe, Emmanuel
Wanzira, Humphrey
Bigira, Victor
Kakuru, Abel
Kamya, Moses
Tappero, Jordan W.
Sandison, Taylor
Dorsey, Grant
TI Effect of Nutritional Status on Response to Treatment with
Artemisinin-Based Combination Therapy in Young Ugandan Children with
Malaria
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID TREATING UNCOMPLICATED MALARIA; PROTEIN-ENERGY MALNUTRITION;
DIHYDROARTEMISININ-PIPERAQUINE; COTRIMOXAZOLE PROPHYLAXIS;
ARTEMETHER-LUMEFANTRINE; MALNOURISHED CHILDREN; PRESCHOOL-CHILDREN;
FALCIPARUM-MALARIA; AFRICAN CHILDREN; MORBIDITY
AB The relationship between malnutrition and malaria in young children is under debate, and no studies evaluating the association between malnutrition and response to artemisinin-based combination therapies (ACTs) have been published. We evaluated the association between malnutrition and response to antimalarial therapy in Ugandan children treated with ACTs for repeated episodes of malaria. Children aged 4 to 12 months diagnosed with uncomplicated malaria were randomized to dihydroartemisinin-piperaquine (DP) or artemether-lumefantrine (AL) and followed for up to 2 years. All HIV-exposed and HIV-infected children received trimethoprim-sulfamethoxazole prophylaxis (TS). The primary exposure variables included height-for-age and weight-for-age z scores. Outcomes included parasite clearance at days 2 and 3 and risk of recurrent parasitemia after 42 days of follow-up. Two hundred ninety-two children were randomized to DP or AL, resulting in 2,013 malaria treatments. Fewer than 1% of patients had a positive blood smear by day 3 (DP, 0.2%; AL, 0.6% [P = 0.18]). There was no significant association between height-for-age or weight-for-age z scores and a positive blood smear 2 days following treatment. For children treated with DP but not on TS, decreasing height-for-age z scores of < - 1 were associated with a higher risk of recurrent parasitemia than a height-forage z score of > 0 (hazard ratio [HR] for height-for-age z score of < - 1 and >= - 2 = 2.89 [P = 0.039]; HR for height-for-age z score of < - 2 = 3.18 [P = 0.022]). DP and AL are effective antimalarial therapies in chronically malnourished children in a high-transmission setting. However, children with mild to moderate chronic malnutrition not taking TS are at higher risk for recurrent parasitemia and may be considered a target for chemoprevention.
C1 [Verret, Wendy J.] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, Berkeley, CA 94720 USA.
[Arinaitwe, Emmanuel; Wanzira, Humphrey; Bigira, Victor; Kakuru, Abel] Univ California, Makerere Univ, Kampala, Uganda.
[Kamya, Moses] Makerere Univ, Sch Med, Dept Med, Kampala, Uganda.
[Tappero, Jordan W.] Ctr Dis Control & Prevent, Global AIDS Program, Atlanta, GA USA.
[Sandison, Taylor] Univ Washington, Dept Med, Seattle, WA USA.
[Dorsey, Grant] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Med, San Francisco, CA USA.
RP Verret, WJ (reprint author), Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, 101 Haviland Hall, Berkeley, CA 94720 USA.
EM wverret@cal.berkeley.edu
FU Doris Duke Charitable Foundation; Centers for Disease Control and
Prevention; Puget Sound Partners in Global Health; NIH/NIAID
[K23-AI082553]; Doris Duke Clinical Scientist Development Award
FX We are grateful to all the parents/guardians for kindly giving their
consent and the study participants for their cooperation. We thank the
members of the Tororo study team. The research was carried out by the
Makerere University-University of California, San Francisco Malaria
Research Collaboration, supported by the Doris Duke Charitable
Foundation and the Centers for Disease Control and Prevention. G.D. is a
recipient of the Doris Duke Clinical Scientist Development Award. T.S.
was funded through the Puget Sound Partners in Global Health and
NIH/NIAID K23-AI082553.
NR 32
TC 9
Z9 9
U1 1
U2 9
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD JUN
PY 2011
VL 55
IS 6
BP 2629
EP 2635
DI 10.1128/AAC.01727-10
PG 7
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 765NA
UT WOS:000290713400020
PM 21383095
ER
PT J
AU Unger, ER
Steinau, M
Lin, JMS
Patel, SS
Swan, DC
AF Unger, Elizabeth R.
Steinau, Martin
Lin, Jin-Mann S.
Patel, Sonya S.
Swan, David C.
TI Impact of HPV Assay on Observed Population Prevalence
SO DIAGNOSTIC MOLECULAR PATHOLOGY
LA English
DT Article
DE human papillomavirus; epidemiology; genotyping assays
ID HUMAN-PAPILLOMAVIRUS DNA; LINEAR-ARRAY; INFECTION; CANCER
AB Type-specific surveillance of human papillomavirus (HPV) has been proposed as an early indicator of vaccine impact. Longitudinal comparison of HPV typing results requires stable assays with high type-specific reproducibility. Assays are evolving and the impact of even minor changes in the assay format may be difficult to anticipate. We initiated a population-based study of HPV with the prototype line blot (PLB) assay. These reagents were replaced by the research use only Linear Array (LA) HPV Genotyping kit. The assays are similar in principle and earlier comparisons found increased sensitivity and detection of more types per sample with LA; however, in samples from women with cervical abnormalities, the overall concordance was good. Slight changes in sensitivity may be more significant in samples from a general population with lower viral loads in the samples. Residual extracts from 3001 self-collected vaginal swabs from women in the general US population originally tested with PLB were retested with LA. With LA, all the samples were hybridized. PLB hybridization was restricted to samples with probable amplicon in gel electrophoresis. For HPV detection, the agreement between the 2 assays was 78.6% (kappa = 0.55) with a positive concordance of 52.8%. However, this masks the observation that repeat testing with LA led to the detection of HPV in nearly twice as many samples. Agreement improves if comparison was restricted to the samples hybridized. These results emphasize that assay comparisons should consider the clinical-epidemiologic context of sample collection. Studies designed to examine temporal trends in type-specific prevalence should archive residual material to permit retesting if assays change.
C1 [Unger, Elizabeth R.; Steinau, Martin; Lin, Jin-Mann S.; Patel, Sonya S.; Swan, David C.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot, Chron Viral Dis Branch, Atlanta, GA 30333 USA.
RP Unger, ER (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot, Chron Viral Dis Branch, MS G41, Atlanta, GA 30333 USA.
EM eunger@cdc.gov
OI Unger, Elizabeth/0000-0002-2925-5635
NR 8
TC 4
Z9 4
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1052-9551
J9 DIAGN MOL PATHOL
JI Diagn. Mol. Pathol.
PD JUN
PY 2011
VL 20
IS 2
BP 101
EP 104
DI 10.1097/PDM.0b013e3181f56fa5
PG 4
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Pathology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Pathology
GA 764VI
UT WOS:000290662100006
PM 21532491
ER
PT J
AU Nguyen, DC
Scinicariello, F
Attanasio, R
AF Nguyen, Doan C.
Scinicariello, Franco
Attanasio, Roberta
TI Characterization and allelic polymorphisms of rhesus macaque (Macaca
mulatta) IgG Fc receptor genes
SO IMMUNOGENETICS
LA English
DT Article
DE Fc receptor; Fc gamma R; CD16; CD32; CD64; Allele; Polymorphism; Rhesus
macaque
ID GAMMA RECEPTOR; IMMUNOGLOBULIN; HETEROGENEITY; ANTIBODIES; DISEASE;
CHINESE; SIVMAC; PATHOGENESIS; RECOGNITION; SUPERFAMILY
AB Macaque models are invaluable for AIDS research. Indeed, initial development of HIV-1 vaccines relies heavily on simian immunodeficiency virus-infected rhesus macaques. Neutralizing antibodies, a major component of anti-HIV protective responses, ultimately interact with Fc receptors on phagocytic and natural killer cells to eliminate the pathogen. Despite the major role that Fc receptors play in protective responses, there is very limited information available on these molecules in rhesus macaques. Therefore, in this study, rhesus macaque CD32 (Fc gamma RII) and CD64 (Fc gamma RI) homologues were genetically characterized. In addition, presence of CD16 (Fc gamma RIII), CD32, and CD64 allelic polymorphisms were determined in a group of nine animals. Results from this study show that the predicted structures of macaque CD32 and CD64 are highly similar to their human counterparts. Macaque and human CD32 and CD64 extracellular domains are 88-90% and 94-95% homologous, respectively. Although all cysteines are conserved between the two species, macaque CD32 exhibits two additional N-linked glycosylation sites, whereas CD64 lacks three of them when compared to humans. Five CD32, three CD64, and three CD16 distinct allelic sequences were indentified in the nine animals examined, indicating a relatively high level of polymorphism in macaque Fc gamma receptors. Together, these results validate rhesus macaques as models for vaccine development and antibody responses, while at the same time, underscoring the need to take into account the high degree of genetic heterogeneity present in this species when designing experimental protocols.
C1 [Nguyen, Doan C.; Attanasio, Roberta] Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA.
[Scinicariello, Franco] Ctr Dis Control & Prevent, Agcy Tox Subst, Div Toxicol & Environm Med, Atlanta, GA 30333 USA.
[Scinicariello, Franco] Ctr Dis Control & Prevent, Dis Registry, Atlanta, GA 30333 USA.
RP Attanasio, R (reprint author), Georgia State Univ, Dept Biol, POB 4010, Atlanta, GA 30303 USA.
EM rattanasio@gsu.edu
FU NIH [R21 AI078855]; GSU Office of Research; Georgia Research Alliance
FX This work was supported in part by NIH grant R21 AI078855, by the
Research Program Enhancement from the GSU Office of Research and
Sponsored Programs and by the Georgia Research Alliance. The authors
thank the Language Research Center of Georgia State University, Dr.
Michael Hart and Matthew Davis for providing and collecting all rhesus
macaque blood samples used in this study.
NR 41
TC 18
Z9 18
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0093-7711
J9 IMMUNOGENETICS
JI Immunogenetics
PD JUN
PY 2011
VL 63
IS 6
BP 351
EP 362
DI 10.1007/s00251-011-0514-z
PG 12
WC Genetics & Heredity; Immunology
SC Genetics & Heredity; Immunology
GA 763FR
UT WOS:000290541200003
PM 21327607
ER
PT J
AU Sarisky, J
Gerding, J
AF Sarisky, John
Gerding, Justin
TI Environmental Public Health Systems and Services Research
SO JOURNAL OF ENVIRONMENTAL HEALTH
LA English
DT Article
AB Editor's Note: NEHA strives to provide up-to-date and relevant information on environmental health and to build partnerships in the profession. In pursuit of these goals, we feature a column from the Environmental Health Services Branch (EHSB) of the Centers for Disease Control and Prevention (CDC) in every issue of the Journal.
In this column, EHSB and guest authors from across CDC will highlight a variety of concerns, opportunities, challenges, and successes that we all share in environmental public health. EHSB's objective is to strengthen the role of state, local, and national environmental health programs and professionals to anticipate, identify, and respond to adverse environmental exposures and the consequences of these exposures for human health. The services being developed through EHSB include access to topical, relevant, and scientific information; consultation; and assistance to environmental health specialists, sanitarians, and environmental health professionals and practitioners.
The conclusions in this article are those of the author(s) and do not necessarily represent the views of the Centers for Disease Control and Prevention.
CAPT John Sarisky and LCDR Justin Gerding are environmental health officers in the Environmental Health Services Branch.
C1 [Sarisky, John] Natl Ctr Environm Hlth, Environm Hlth Serv Branch, Div Emergency & Environm Hlth Serv, Atlanta, GA 30341 USA.
RP Sarisky, J (reprint author), Natl Ctr Environm Hlth, Environm Hlth Serv Branch, Div Emergency & Environm Hlth Serv, Atlanta, GA 30341 USA.
EM JSarisky@cdc.gov
NR 4
TC 0
Z9 0
U1 0
U2 0
PU NATL ENVIRON HEALTH ASSOC
PI DENVER
PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA
SN 0022-0892
J9 J ENVIRON HEALTH
JI J. Environ. Health
PD JUN
PY 2011
VL 73
IS 10
BP 24
EP 25
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 768HF
UT WOS:000290923900005
PM 21667721
ER
PT J
AU Fujishiro, K
Landsbergis, PA
Diez-Roux, AV
Stukovsky, KH
Shrager, S
Baron, S
AF Fujishiro, Kaori
Landsbergis, Paul A.
Diez-Roux, Ana V.
Stukovsky, Karen Hinckley
Shrager, Sandi
Baron, Sherry
TI Factorial Invariance, Scale Reliability, and Construct Validity of the
Job Control and Job Demands Scales for Immigrant Workers: The
Multi-Ethnic Study of Atherosclerosis
SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH
LA English
DT Article
DE Job stress; Factor analysis; Internal consistency; Acculturation; Health
disparities
ID SELF-RATED HEALTH; DECISION LATITUDE; SOCIAL-CLASS; LIFE-STYLE; STRESS;
QUESTIONNAIRE; MORTALITY; STRAIN; WOMEN; MEN
AB Immigrants have a different social context from those who stay in their home country or those who were born to the country that immigrants now live. Cultural theory of risk perception suggests that social context influences one's interpretation of questionnaire items. We examined psychometric properties of job control and job demand scales with US- and foreign-born workers who preferred English, Spanish, or Chinese (n = 3,114, mean age = 58.1). Across all groups, the job control scale had acceptable Cronbach's alpha (0.78-0.83) and equivalent factor loadings (Delta CFI < 0.01). Immigrants had low alpha (0.42-0.65) for the job demands scale regardless of language, education, or age of migration. Two job-demand items had different factor loadings across groups. Among immigrants, both scales had inconsistent associations with perceived job stress and self-rated health. For a better understanding of immigrants' job stress, the concept of job demands should be expanded and immigrants' expectations for job control explored.
C1 [Fujishiro, Kaori; Baron, Sherry] NIOSH, Cincinnati, OH 45226 USA.
[Landsbergis, Paul A.] Suny Downstate Med Ctr, New York, NY USA.
[Diez-Roux, Ana V.] Univ Michigan, Ann Arbor, MI 48109 USA.
[Stukovsky, Karen Hinckley; Shrager, Sandi] Univ Washington, Seattle, WA 98195 USA.
RP Fujishiro, K (reprint author), NIOSH, 4676 Columbia Pkwy R-15, Cincinnati, OH 45226 USA.
EM kfujishiro@cdc.gov
FU NHLBI NIH HHS [N01HC95162, N01 HC095159, N01-HC-95159, N01-HC-95160,
N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165,
N01-HC-95169, N01HC95159, N01HC95160, N01HC95161, N01HC95163,
N01HC95164, N01HC95165, N01HC95169]; PHS HHS [FY08 CRN SLB8]
NR 40
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U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1557-1912
J9 J IMMIGR MINOR HEALT
JI J. Immigr. Minor. Health
PD JUN
PY 2011
VL 13
IS 3
BP 533
EP 540
DI 10.1007/s10903-010-9364-2
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 760TF
UT WOS:000290346000016
PM 20582720
ER
PT J
AU Chen, SY
Anderson, S
Kutty, PK
Lugo, F
McDonald, M
Rota, PA
Ortega-Sanchez, IR
Komatsu, K
Armstrong, GL
Sunenshine, R
Seward, JF
AF Chen, Sanny Y.
Anderson, Shoana
Kutty, Preeta K.
Lugo, Francelli
McDonald, Michelle
Rota, Paul A.
Ortega-Sanchez, Ismael R.
Komatsu, Ken
Armstrong, Gregory L.
Sunenshine, Rebecca
Seward, Jane F.
TI Health Care-Associated Measles Outbreak in the United States After an
Importation: Challenges and Economic Impact
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID TRANSMISSION; SETTINGS; ELIMINATION; INFECTION
AB Background. On 12 February 2008, an infected Swiss traveler visited hospital A in Tucson, Arizona, and initiated a predominantly health care-associated measles outbreak involving 14 cases. We investigated risk factors that might have contributed to health care-associated transmission and assessed outbreak-associated hospital costs.
Methods. Epidemiologic data were obtained by case interviews and review of medical records. Health care personnel (HCP) immunization records were reviewed to identify non-measles-immune HCP. Outbreak-associated costs were estimated from 2 hospitals.
Results. Of 14 patients with confirmed cases, 7 (50%) were aged >= 18 years, 4 (29%) were hospitalized, 7 (50%) acquired measles in health care settings, and all (100%) were unvaccinated or had unknown vaccination status. Of the 11 patients (79%) who had accessed health care services while infectious, 1 (9%) was masked and isolated promptly after rash onset. HCP measles immunity data from 2 hospitals confirmed that 1776 (25%) of 7195 HCP lacked evidence of measles immunity. Among these HCPs, 139 (9%) of 1583 tested seronegative for measles immunoglobulin G, including 1 person who acquired measles. The 2 hospitals spent US$799,136 responding to and containing 7 cases in these facilities.
Conclusions. Suspecting measles as a diagnosis, instituting immediate airborne isolation, and ensuring rapidly retrievable measles immunity records for HCPs are paramount in preventing health care-associated spread and in minimizing hospital outbreak-response costs.
C1 [Chen, Sanny Y.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA.
[Chen, Sanny Y.; Anderson, Shoana; Komatsu, Ken; Sunenshine, Rebecca] Arizona Dept Hlth Serv, Bur Epidemiol & Dis Control Serv, Phoenix, AZ 85007 USA.
[Kutty, Preeta K.; Rota, Paul A.; Ortega-Sanchez, Ismael R.; Armstrong, Gregory L.; Seward, Jane F.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA 30333 USA.
[Lugo, Francelli; McDonald, Michelle] Pima Cty Hlth Dept, Div Dis Control & Prevent, Tucson, AZ USA.
[Sunenshine, Rebecca] Ctr Dis Control & Prevent, Career Epidemiol Field Off, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA.
RP Chen, SY (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, 1600 Clifton Rd,MS E-30, Atlanta, GA 30333 USA.
EM sychen@cdc.gov
FU Centers for Disease Control and Prevention; State of Arizona
FX Centers for Disease Control and Prevention and the State of Arizona
provided funding to support this investigation.
NR 20
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U1 3
U2 13
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD JUN 1
PY 2011
VL 203
IS 11
BP 1517
EP 1525
DI 10.1093/infdis/jir115
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 767LT
UT WOS:000290858800004
PM 21531693
ER
PT J
AU Pierson, DL
Mehta, SK
Gilden, D
Cohrs, RJ
Nagel, MA
Schmid, DS
Tyring, SK
AF Pierson, Duane L.
Mehta, Satish K.
Gilden, Don
Cohrs, Randall J.
Nagel, Maria A.
Schmid, D. Scott
Tyring, Stephen K.
TI Varicella Zoster Virus DNA at Inoculation Sites and in Saliva After
Zostavax Immunization
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID HERPES-ZOSTER; VACCINE; REACTIVATION; ASTRONAUTS; RASH
AB Analysis of 36 individuals over age 60 years who were immunized with Zostavax revealed varicella zoster virus (VZV) DNA in swabs of skin inoculation sites obtained immediately after immunization in 18 (50%) of 36 subjects (copy number per nanogram of total DNA, 28 to 2.1 x 10(6)) and in saliva collected over 28 days in 21 (58%) of 36 subjects (copy number, 20 to 248). Genotypic analysis of DNA extracted from 9 random saliva samples identified vaccine virus in all instances. In some immunized individuals over age 60, vaccine virus DNA is shed in saliva up to 4 weeks.
C1 [Gilden, Don; Cohrs, Randall J.; Nagel, Maria A.] Univ Colorado, Sch Med, Dept Neurol, Aurora, CO 80045 USA.
[Pierson, Duane L.] NASA, Lyndon B Johnson Space Ctr, Houston, TX 77058 USA.
[Mehta, Satish K.] Enterprise Advisory Serv Inc, Houston, TX USA.
[Tyring, Stephen K.] Univ Texas Hlth Sci Ctr, Houston, TX USA.
[Schmid, D. Scott] Ctr Dis Control & Prevent, Natl VZV Lab, Atlanta, GA USA.
RP Gilden, D (reprint author), Univ Colorado, Sch Med, Dept Neurol, 12700 E 19th Ave,Box B182, Aurora, CO 80045 USA.
EM don.gilden@ucdenver.edu
FU National Institutes of Health [AG032958, AG006127, NS067070]; National
Aeronautics and Space Administration [SMO-015]
FX This work was supported by the National Institutes of Health (grant
AG032958 to D. G. and R. J. C.; grant AG006127 to D. G.; and grant
NS067070 to M. A. N.) and National Aeronautics and Space Administration
(grant SMO 015 to D. L. P). National Institutes of Health (grant
AG032958 to D. G. and R. J. C.; grant AG006127 to D. G.; and grant
NS067070 to M. A. N.) and National Aeronautics and Space Administration
(SMO-015 to D. L. P.).
NR 15
TC 10
Z9 10
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD JUN 1
PY 2011
VL 203
IS 11
BP 1542
EP 1545
DI 10.1093/infdis/jir139
PG 4
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 767LT
UT WOS:000290858800007
PM 21592982
ER
PT J
AU Livingston, L
Sweeney, E
Mitchell, J
Luo, W
Paul, K
Powell, N
Hendry, RM
McNicholl, J
Kersh, E
AF Livingston, Lindsay
Sweeney, Elizabeth
Mitchell, James
Luo, Wei
Paul, Katherine
Powell, Nathaniel
Hendry, R. Michael
McNicholl, Janet
Kersh, Ellen
TI Hormonal synchronization of the menstrual cycles of pigtail macaques to
facilitate biomedical research including modeling HIV susceptibility
SO JOURNAL OF MEDICAL PRIMATOLOGY
LA English
DT Article
DE contraceptive; human immunodeficiency virus; low-dose vaginal
inoculation; macaque; menstrual cycle; non-human primate; pigtail;
simian human immunodeficiency virus; synchronization
ID BABOONS PAPIO-ANUBIS; VAGINAL TRANSMISSION; STRATEGY; VIRUS; SIV
AB Background
Menstrual cycle synchronization of female pigtail macaques could prove an invaluable resource in studies of the reproductive tract, associated infections, and other potential research fields. We tested whether use of an oral progesterone and estradiol combination tablet could synchronize menstrual cycles following treatment discontinuation.
Methods
Daily desogestrel 0.075 mg and ethinyl estradiol 0.01 mg were administered orally to three pigtail macaques at visual onset of perineal sex swelling and were continued until all animals had received it for at least 45 days. The hormones were discontinued, and these three macaques and three controls were observed for menstruation and had blood progesterone and estrogen measured over an additional 2-month period.
Results
All treatment animals showed spontaneous menstrual cycle synchronization for 2 months after menstrual cycling resumed.
Conclusion
Progesterone and estradiol combination therapy can be used in pigtail macaques to induce synchronized cycling that persists in the absence of on-going hormone treatments.
C1 [Sweeney, Elizabeth; Mitchell, James; Luo, Wei; Hendry, R. Michael; McNicholl, Janet; Kersh, Ellen] CDC, Div HIV AIDS Prevent, NCHHSTP, Atlanta, GA 30333 USA.
[Livingston, Lindsay; Paul, Katherine; Powell, Nathaniel] CDC, Div Sci Resources, NCEZID, Atlanta, GA 30333 USA.
RP Kersh, E (reprint author), CDC, Div HIV AIDS Prevent, NCHHSTP, Atlanta, GA 30333 USA.
EM egk6@cdc.gov
NR 11
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U1 0
U2 6
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0047-2565
J9 J MED PRIMATOL
JI J. Med. Primatol.
PD JUN
PY 2011
VL 40
IS 3
BP 164
EP 170
DI 10.1111/j.1600-0684.2010.00465.x
PG 7
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 766GI
UT WOS:000290768600002
PM 21241313
ER
PT J
AU Coats, MT
Murphy, T
Paton, JC
Gray, B
Briles, DE
AF Coats, Mamie T.
Murphy, Trudy
Paton, James C.
Gray, Barry
Briles, David E.
TI Exposure of Thomsen-Friedenreich antigen in Streptococcus pneumoniae
infection is dependent on pneumococcal neuraminidase A
SO MICROBIAL PATHOGENESIS
LA English
DT Article
DE Streptococcus pneumoniae; Hemolytic uremic syndrome;
Thomsen-Friedenreich antigen; Neuraminidase
ID HEMOLYTIC-UREMIC SYNDROME; SURFACE PROTEIN-A; RESPIRATORY-TRACT;
ESCHERICHIA-COLI; OTITIS-MEDIA; T-ANTIGEN; PNEUMOLYSIN; DISEASE;
PURIFICATION; VIRULENCE
AB Pneumococcal hemolytic uremic syndrome is recognized in a small portion of otherwise healthy children who have or have recently had Streptococcus pneumoniae infections, including severe pneumonia, meningitis, and bacteremia. As in other types of hemolytic uremic syndrome (HUS), pneumococcal HUS is characterized by microangiopathic hemolytic anemia, and thrombocytopenia, usually with extensive kidney damage. Although not demonstrated in vivo, the pathogenesis of pneumococcal HUS has been attributed to the action pneumococcal neuraminidase exposing the usually cryptic Thomsen-Friedenreich antigen (T-antigen) on red blood cells (RBC), and kidney glomeruli. We evaluated the effect of pneumococcal infection on desialylation of RBC and glomeruli during pneumococcal infections in mice. Following intravenous infection with capsular type 19F pneumococci, CFU levels exceeding 1000 CFU/mL blood by the third day were significantly more likely to result in exposed T-antigen on RBC than lower levels of bacteremia. In a pneumonia model, significantly more T-antigen was exposed on RBC in mice treated with penicillin than in those receiving mock treatment. Utilizing mutant pneumococci, we demonstrated that neuraminidase A but not neuraminidase B was necessary for exposure of T-antigen on RBC in vivo. Thus, pneumococcal neuraminidase A is necessary for the exposure of T-antigen in vivo and treatment with penicillin increases this effect. Interestingly, NanA(-) pneumococci were found in the blood in higher numbers and caused more deaths than wild type, NanB(-), or the NanA(-)/NanB(-) pneumococci. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Coats, Mamie T.; Briles, David E.] Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA.
[Murphy, Trudy] Ctr Dis Control & Prevent, Off Director, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Paton, James C.] Univ Adelaide, Sch Mol & Biomed Sci, Res Ctr Infect Dis, Adelaide, SA, Australia.
[Gray, Barry] Univ Illinois, Dept Pediat, Peoria, IL USA.
[Briles, David E.] Univ Alabama, Dept Pediat, Birmingham, AL 35294 USA.
RP Briles, DE (reprint author), Univ Alabama, Dept Microbiol, 1530 3rd Ave S, Birmingham, AL 35294 USA.
EM dbriles@uab.edu
RI Paton, James/A-9920-2008
FU NIH [AI21548]; Ruth L. Kirschstein National Research Service Award
FX This work was supported by NIH grant AI21548 to D.E.B. Mamie T. Coats
was supported by the Ruth L. Kirschstein National Research Service
Award.
NR 49
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U1 0
U2 3
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0882-4010
J9 MICROB PATHOGENESIS
JI Microb. Pathog.
PD JUN
PY 2011
VL 50
IS 6
BP 343
EP 349
DI 10.1016/j.micpath.2011.02.010
PG 7
WC Immunology; Microbiology
SC Immunology; Microbiology
GA 767GJ
UT WOS:000290843000011
PM 21377521
ER
PT J
AU Toblin, RL
Mack, KA
Perveen, G
Paulozzi, LJ
AF Toblin, Robin L.
Mack, Karin A.
Perveen, Ghazala
Paulozzi, Leonard J.
TI A population-based survey of chronic pain and its treatment with
prescription drugs
SO PAIN
LA English
DT Article
DE Epidemiology; Opioid analgesics; Risk factors; Pain measurement
ID CHRONIC NONCANCER PAIN; PERSISTENT PAIN; UNITED-STATES; OPIOIDS;
EPIDEMIOLOGY; COMMUNITY; OVERDOSE; PREVALENCE; GUIDELINES; MANAGEMENT
AB Chronic pain is a common reason for medical visits, but prevalence estimates vary between studies and have rarely included drug treatment data. This study aimed to examine characteristics of chronic pain and its relation to demographic and health factors, and factors associated with treatment of pain with opioid analgesics. A chronic pain module was added to the 2007 Kansas Behavioral Risk Factor Surveillance System (response rate = 61%). Data on prevalence, duration, frequency, and severity of chronic pain, demographics, and health were collected from a representative sample of 4090 adults 18 years and older by telephone. Logistic regression was used to examine the association of both chronic pain and opioid use with demographic and health factors. Chronic pain was reported by 26.0% of the participants and was associated with activity limitations (adjusted odds ratio [AOR] = 3.6, 95% confidence interval [95% CI] 2.8-4.5), arthritis (AOR = 3.3, 95% CI 2.6-4.0), poor mental health (AOR = 2.0, 95% CI 1.4-2.8), poor overall health (AOR = 1.9; 95% CI 1.5-2.5), and obesity (AOR = 1.6; 95% CI 1.2-2.0). Of the 33.4% of people with pain who use prescription pain medication, 45.7% took opioids, including 36.7% of those with mild pain. Chronic pain affects a quarter of adults in Kansas and is associated with poor health. Opioid analgesics are the mainstay of prescribed pharmacotherapy in this group, even among those reporting mild pain. Published by Elsevier B.V. on behalf of International Association for the Study of Pain.
C1 [Toblin, Robin L.; Mack, Karin A.; Paulozzi, Leonard J.] Ctr Dis Control & Prevent, NCIPC, Atlanta, GA 30341 USA.
[Toblin, Robin L.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA.
[Perveen, Ghazala] Bur Hlth Promot, Kansas Dept Hlth & Environm, Topeka, KS 66612 USA.
RP Toblin, RL (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Mil Psychiat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM robin.l.toblin@us.army.mil
RI Mack, Karin/A-3263-2012
OI Mack, Karin/0000-0001-9274-3001
FU Centers for Disease Control and Prevention
FX The contents of this article are solely the responsibility of the
authors and do not necessarily represent the official views of the US
Centers for Disease Control and Prevention or the Kansas Department of
Health and Environment. None of the authors has any relevant financial
interest in this article. The authors have no conflicts of interest.
This work was accomplished entirely using internal funding supplied by
the Centers for Disease Control and Prevention.
NR 39
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U1 1
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3959
J9 PAIN
JI Pain
PD JUN
PY 2011
VL 152
IS 6
BP 1249
EP 1255
DI 10.1016/j.pain.2010.12.036
PG 7
WC Anesthesiology; Clinical Neurology; Neurosciences
SC Anesthesiology; Neurosciences & Neurology
GA 765MD
UT WOS:000290710100010
PM 21397401
ER
PT J
AU Brewer, RD
AF Brewer, R. D.
TI ALCOHOL POLICY SURVEILLANCE AND PUBLIC HEALTH
SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Meeting Abstract
CT 34th Annual Scientific Meeting of the Research-Society-on-Alcoholism
CY JUN 25-29, 2011
CL Atlanta, GA
SP Res Soc Alcoholism
C1 [Brewer, R. D.] US Ctr Dis Control & Prevent, Alcohol Team, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0145-6008
J9 ALCOHOL CLIN EXP RES
JI Alcoholism (NY)
PD JUN
PY 2011
VL 35
IS 6
SU S
BP 277A
EP 277A
PG 1
WC Substance Abuse
SC Substance Abuse
GA 766RN
UT WOS:000290804301560
ER
PT J
AU Adams, M
Mandel, D
AF Adams, M.
Mandel, D.
TI USING CAUSE-OF-DEATH TEXTS ON DEATH CERTIFICATES TO IDENTIFY DEATHS FROM
SPECIFIC RARE DISEASES.
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Adams, M.; Mandel, D.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S285
EP S285
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601400
ER
PT J
AU Azofeifa, A
Duke, C
Gilboa, S
Correa, A
Yeung, L
AF Azofeifa, A.
Duke, C.
Gilboa, S.
Correa, A.
Yeung, L.
TI EVALUATION OF ACTIVE SURVEILLANCE OF STILLBIRTH: UTILITY OF AN EXISTING
BIRTH DEFECTS SURVEILLANCE PROGRAM - ATLANTA, GEORGIA
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Azofeifa, A.; Duke, C.; Gilboa, S.; Correa, A.; Yeung, L.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S213
EP S213
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601131
ER
PT J
AU Bloss, E
Chan, PC
Cheng, NW
Wang, KF
Yang, SL
Cegielski, P
AF Bloss, E.
Chan, P-C
Cheng, N-W
Wang, K-F
Yang, S-L
Cegielski, P.
TI EVALUATION OF DIRECTLY OBSERVED THERAPY ON TUBERCULOSIS TREATMENT
OUTCOMES IN TAIWAN
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Bloss, E.; Chan, P-C; Cheng, N-W; Wang, K-F; Yang, S-L; Cegielski, P.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S181
EP S181
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601001
ER
PT J
AU Burrows, NR
Cho, P
Hora, I
Geiss, L
AF Burrows, N. R.
Cho, P.
Hora, I.
Geiss, L.
TI LOW PREVALENCE OF SELF-REPORTED PREDIABETES AMONG ADULTS IN THE UNITED
STATES, 2007-2009
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Burrows, N. R.; Cho, P.; Hora, I.; Geiss, L.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S308
EP S308
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601493
ER
PT J
AU Duong, LM
Wilson, RJ
Ajani, UA
Singh, SD
Eheman, CR
AF Duong, L. M.
Wilson, R. J.
Ajani, U. A.
Singh, S. D.
Eheman, C. R.
TI TRENDS IN ENDOMETRIAL CANCER INCIDENCE RATES IN THE UNITED STATES,
1999-2006.
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Duong, L. M.; Wilson, R. J.; Ajani, U. A.; Singh, S. D.; Eheman, C. R.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S302
EP S302
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601468
ER
PT J
AU Duwe, KN
Cassell, C
Levis, D
Stone-Wiggins, B
Council, M
O'Hegarty, M
AF Duwe, K. N.
Cassell, C.
Levis, D.
Stone-Wiggins, B.
Council, M.
O'Hegarty, M.
TI FOCUS GROUP RESULTS ON CIGARETTE SMOKING DURING PREGNANCY AND ADVERSE
OUTCOMES.
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Duwe, K. N.; Cassell, C.; Levis, D.; Stone-Wiggins, B.; Council, M.; O'Hegarty, M.] Ctr Dis Control & Prevent, Decatur, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S149
EP S149
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600581
ER
PT J
AU Flak, AL
Su, S
Bertrand, J
Denny, CH
Kesmodel, US
Cogswell, ME
AF Flak, A. L.
Su, S.
Bertrand, J.
Denny, C. H.
Kesmodel, U. S.
Cogswell, M. E.
TI THE ASSOCIATION OF MILD, MODERATE, AND BINGE PRENATAL ALCOHOL USE AND
CHILD NEUROPSYCHOLOGICAL OUTCOMES: A META-ANALYSIS
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Flak, A. L.; Su, S.; Bertrand, J.; Denny, C. H.; Kesmodel, U. S.; Cogswell, M. E.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S136
EP S136
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600528
ER
PT J
AU Fryar, C
AF Fryar, C.
TI TWENTY-FIVE YEARS OF HIGH BLOOD PRESSURE FINDINGS AMONG MEXICAN AMERICAN
ADULTS IN THE US
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Fryar, C.] Natl Ctr Hlth Stat, CDC, Hyattsville, MD 20782 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S93
EP S93
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600365
ER
PT J
AU Geiss, LS
Wang, J
Gregg, EW
AF Geiss, L. S.
Wang, J.
Gregg, E. W.
TI USE OF EMERGENCY DEPARTMENTS FOR DIABETES WITH HYPOGLYCEMIA, UNITED
STATES 2008.
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Geiss, L. S.; Wang, J.; Gregg, E. W.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S154
EP S154
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600600
ER
PT J
AU Gilboa, SM
Broussard, CS
Devine, O
Duwe, KN
Flak, AL
Boulet, SL
Moore, CA
Werler, MM
Honein, MA
AF Gilboa, S. M.
Broussard, C. S.
Devine, O.
Duwe, K. N.
Flak, A. L.
Boulet, S. L.
Moore, C. A.
Werler, M. M.
Honein, M. A.
TI MODELING THE POTENTIAL IMPACT OF SHIFTING PRENATAL ANTI-EPILEPTIC
MEDICATION PRESCRIBING PRACTICES ON THE PREVALENCE OF SELECTED BIRTH
DEFECTS.
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Gilboa, S. M.; Broussard, C. S.; Devine, O.; Duwe, K. N.; Flak, A. L.; Boulet, S. L.; Moore, C. A.; Werler, M. M.; Honein, M. A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S283
EP S283
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601394
ER
PT J
AU Gladden, R
Vagi, K
Patel, N
Lipskiy, N
Benoit, S
English, R
Dey, A
Crosby, A
AF Gladden, R.
Vagi, K.
Patel, N.
Lipskiy, N.
Benoit, S.
English, R.
Dey, A.
Crosby, A.
TI MONITORING EMERGENCY DEPARTMENT (ED) VISITS FOR SUICIDE IDEATION AND
ATTEMPTS DURING THE US ECONOMIC RECESSION USING BIOSENSE, 2008-2009
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Gladden, R.; Vagi, K.; Patel, N.; Lipskiy, N.; Benoit, S.; English, R.; Dey, A.; Crosby, A.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 1
Z9 1
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S291
EP S291
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601426
ER
PT J
AU Gurley, L
AF Gurley, L.
TI HEALTHY PEOPLE 2010: FINAL ASSESSMENT OF PROGRESS AND DISPARITIES
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Gurley, L.] CDC, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S19
EP S19
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600072
ER
PT J
AU Hall, IJ
Johnson-Turbes, C
Kamalu, N
AF Hall, I. J.
Johnson-Turbes, C.
Kamalu, N.
TI EVALUATION OF A COMMUNITY-BASED INTERVENTION TO INCREASE BREAST CANCER
SCREENING AND EARLY DETECTION AMONG LOW-INCOME, AFRICAN AMERICAN WOMEN
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Hall, I. J.; Johnson-Turbes, C.; Kamalu, N.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S1
EP S1
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600003
ER
PT J
AU Kahn, HS
El Ghormli, L
Baranowski, T
Foster, GD
McMurray, RG
Buse, JB
Stadler, DD
Trevino, RP
AF Kahn, H. S.
El Ghormli, L.
Baranowski, T.
Foster, G. D.
McMurray, R. G.
Buse, J. B.
Stadler, D. D.
Trevino, R. P.
CA HEALTHY Study Grp
TI ALTERNATIVE OBESITY INDICES FOR ESTIMATING CARDIOMETABOLIC RISK AND RISK
CHANGE IN YOUTH
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Kahn, H. S.; El Ghormli, L.; Baranowski, T.; Foster, G. D.; McMurray, R. G.; Buse, J. B.; Stadler, D. D.; Trevino, R. P.; HEALTHY Study Grp] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S277
EP S277
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601371
ER
PT J
AU Kruszon-Moran, D
Porter, K
McQuillan, G
Fay, R
VanDeKerckhove, W
Hirsch, R
Curtin, L
AF Kruszon-Moran, D.
Porter, K.
McQuillan, G.
Fay, R.
VanDeKerckhove, W.
Hirsch, R.
Curtin, L.
TI PREVALENCE OF SELECTED HEALTH OUTCOMES AND HEALTH PREDICTORS FOR THE
STATE OF CALIFORNIA: A COMPARISON TO US NATIONAL ESTIMATES (NHANES
1999-2006)
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Kruszon-Moran, D.; Porter, K.; McQuillan, G.; Fay, R.; VanDeKerckhove, W.; Hirsch, R.; Curtin, L.] Ctr Dis Control & Prevent, Hyattsville, MD 20782 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S27
EP S27
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600105
ER
PT J
AU Labarthe, D
AF Labarthe, D.
TI EXPANDING DIMENSIONS OF EPIDEMIOLOGY: POPULOMICS?
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Labarthe, D.] CDC, Div Heart Dis & Stroke Prevent, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S221
EP S221
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601162
ER
PT J
AU Lacher, D
Carroll, M
Wolz, M
Sorlie, P
Srinivas, P
AF Lacher, D.
Carroll, M.
Wolz, M.
Sorlie, P.
Srinivas, P.
TI APOLIPOPROTEIN B LEVELS IN THE UNITED STATES, NATIONAL HEALTH AND
NUTRITION EXAMINATION SURVEY 2005-2008.
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Lacher, D.; Carroll, M.; Wolz, M.; Sorlie, P.; Srinivas, P.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S170
EP S170
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600665
ER
PT J
AU Li, C
Balluz, LS
Ford, ES
Okoro, CA
Tsai, J
Zhao, G
AF Li, C.
Balluz, L. S.
Ford, E. S.
Okoro, C. A.
Tsai, J.
Zhao, G.
TI ASSOCIATION BETWEEN DIAGNOSED DIABETES AND SELF-REPORTED CANCER AMONG US
ADULTS: FINDINGS FROM THE 2009 BEHAVIORAL RISK FACTOR SURVEILLANCE
SYSTEM
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Li, C.; Balluz, L. S.; Ford, E. S.; Okoro, C. A.; Tsai, J.; Zhao, G.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S306
EP S306
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601485
ER
PT J
AU Okoro, CA
Fan, AZ
Zhong, Y
Qi, X
Li, C
Balluz, LS
AF Okoro, C. A.
Fan, A. Z.
Zhong, Y.
Qi, X.
Li, C.
Balluz, L. S.
TI ASSOCIATION BETWEEN THE REGIONAL PREVALENCE OF CHRONIC JOINT SYMPTOMS
AND TEMPERATURE AMONG US ADULTS: FINDINGS FROM THE BEHAVIORAL RISK
FACTOR SURVEILLANCE SYSTEM
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Okoro, C. A.; Fan, A. Z.; Zhong, Y.; Qi, X.; Li, C.; Balluz, L. S.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S54
EP S54
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600208
ER
PT J
AU Pearson, WS
Sugerman, DE
McGuire, LC
AF Pearson, W. S.
Sugerman, D. E.
McGuire, L. C.
TI CHARACTERIZATION OF THE SEVERITY OF TRAUMATIC BRAIN INJURY EMERGENCY
DEPARTMENT VISITS AMONG OLDER ADULTS
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Pearson, W. S.; Sugerman, D. E.; McGuire, L. C.] Ctr Dis Control & Prevent, Div Injury Response, Atlanta, GA 30346 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S202
EP S202
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601086
ER
PT J
AU Phillip, AW
Pollack, LA
Rowland, JH
Mariotto, A
Weir, HK
Alfano, C
AF Phillip, A. W.
Pollack, L. A.
Rowland, J. H.
Mariotto, A.
Weir, H. K.
Alfano, C.
TI CANCER SURVIVORS IN THE UNITED STATES, 2007
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Phillip, A. W.; Pollack, L. A.; Rowland, J. H.; Mariotto, A.; Weir, H. K.; Alfano, C.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S250
EP S250
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601273
ER
PT J
AU Qayad, MG
Chowdhury, PP
Town, GM
Balluz, LS
AF Qayad, M. G.
Chowdhury, P. P.
Town, G. M.
Balluz, L. S.
TI SOCIO-DEMOGRAPHIC DIFFERENCES IN BODY MASS INDEX CHANGES AMONG US ADULTS
IN THE BEHAVIORAL RISK FACTOR SURVEILLANCE SYSTEM DATA (BRFSS).
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Qayad, M. G.; Chowdhury, P. P.; Town, G. M.; Balluz, L. S.] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S261
EP S261
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601314
ER
PT J
AU Robbins, CR
Dietz, PM
Bombard, J
Valderrama, AL
AF Robbins, C. R.
Dietz, P. M.
Bombard, J.
Valderrama, A. L.
TI CARDIOVASCULAR DISEASE SCREENING AMONG WOMEN WITH HISTORIES OF
GESTATIONAL HYPERTENSION
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Robbins, C. R.; Dietz, P. M.; Bombard, J.; Valderrama, A. L.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S67
EP S67
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600262
ER
PT J
AU Saydah, S
Imperatore, G
Beckles, G
AF Saydah, S.
Imperatore, G.
Beckles, G.
TI SOCIOECONOMIC POSITION AND MORTALITY: THE CONTRIBUTION OF HEALTH CARE
ACCESS AND PSYCHOLOGICAL DISTRESS AMONG US ADULTS WITH DIAGNOSED
DIABETES
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Saydah, S.; Imperatore, G.; Beckles, G.] Ctr Dis Control & Prevent, Hyattsville, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S307
EP S307
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601490
ER
PT J
AU Tinker, S
Gibbs, C
Devine, O
Herring, AH
Honein, M
Crider, K
Werler, M
Anderka, M
Reefhuis, J
AF Tinker, S.
Gibbs, C.
Devine, O.
Herring, A. H.
Honein, M.
Crider, K.
Werler, M.
Anderka, M.
Reefhuis, J.
TI SENSITIVITY ASSESSMENT OF THE IMPACT OF TIME TO MATERNAL INTERVIEW ON
INTERVIEW QUALITY IN THE NATIONAL BIRTH DEFECTS PREVENTION STUDY
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Tinker, S.; Gibbs, C.; Devine, O.; Herring, A. H.; Honein, M.; Crider, K.; Werler, M.; Anderka, M.; Reefhuis, J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S292
EP S292
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601431
ER
PT J
AU van Gelder, M
Donders, R
Devine, O
Cleves, M
Roeleveld, N
Reefhuis, J
AF van Gelder, M.
Donders, R.
Devine, O.
Cleves, M.
Roeleveld, N.
Reefhuis, J.
TI ASSESSING THE EFFECT OF EXPOSURE MISCLASSIFICATION ON CANNABIS-BIRTH
DEFECT ASSOCIATIONS: AN APPLICATION OF FREQUENTIST AND BAYESIAN METHODS
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [van Gelder, M.; Donders, R.; Devine, O.; Cleves, M.; Roeleveld, N.; Reefhuis, J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RI Donders, A.R.T./L-4277-2015; Roeleveld, Nel/B-4242-2008
OI Donders, A.R.T./0000-0002-0484-1419; Roeleveld, Nel/0000-0002-3390-4466
NR 0
TC 0
Z9 0
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S185
EP S185
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601017
ER
PT J
AU Vena, J
Mendola, P
AF Vena, J.
Mendola, Pauline
TI MENTORING IN EPIDEMIOLOGY
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Vena, J.; Mendola, Pauline] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S79
EP S79
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600307
ER
PT J
AU Wethington, H
Sherry, B
Park, S
Blanck, H
AF Wethington, H.
Sherry, B.
Park, S.
Blanck, H.
TI PASSIVE AND ACTIVE SCREEN TIME AMONG US YOUTH AGED 9-18 YEARS, 2009
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Wethington, H.; Sherry, B.; Park, S.; Blanck, H.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S277
EP S277
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114601372
ER
PT J
AU Winston, CA
Navin, TR
Becerra, JE
AF Winston, C. A.
Navin, T. R.
Becerra, J. E.
TI COMPARING OBSERVED VERSUS EXPECTED TUBERCULOSIS CASES
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Meeting Abstract
CT 3rd North American Congress of Epidemiology
CY JUN 21-24, 2011
CL Montreal, CANADA
C1 [Winston, C. A.; Navin, T. R.; Becerra, J. E.] Ctr Dis Control & Prevent CDC, Atlanta, GA 30333 USA.
RI Becerra, Jose/C-4071-2014
NR 0
TC 0
Z9 0
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUN 1
PY 2011
VL 173
SU 11
BP S72
EP S72
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 810GU
UT WOS:000294114600282
ER
PT J
AU Pace, JE
Shin, M
Rasmussen, SA
AF Pace, Jill E.
Shin, Mikyong
Rasmussen, Sonja A.
TI Understanding Physicians' Attitudes Toward People With Down Syndrome
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE Down syndrome; physicians; attitudes; intellectual disabilities
ID MORTALITY; DISABILITIES; DIAGNOSIS; SOCIETY
AB Understanding attitudes of physicians toward people with Down syndrome is important because of the influence physicians have on the future of individuals with Down syndrome. However, few previous studies have assessed these attitudes. Using data from the 2008 DocStyles (R) survey, an annual online survey conducted in the United States, we assessed attitudes of physicians toward people with Down syndrome using a survey that included questions about opinions toward inclusive educational settings and workplaces, previous relationships with people with Down syndrome, and comfort in providing them with medical care. Approximately 20% of participants agreed that students with Down syndrome should go to special schools, and nearly a quarter agreed that including students with Down syndrome in regular classrooms is distracting. While 76.0% of respondents felt comfortable providing medical care to people with Down syndrome, 9.8% reported feeling uncomfortable, and 14.3% reported feeling neutral. Results showed that attitudes that supported inclusion and comfort with providing medical care were more commonly reported among non-Hispanic white physicians, those who had previous relationships with people with Down syndrome, pediatricians, and physicians working in a group or hospital setting. These data are helpful to guide the development of training materials and curricula for healthcare providers regarding Down syndrome. Published 2011 Wiley-Liss, Inc.(dagger)
C1 [Pace, Jill E.; Shin, Mikyong; Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Shin, Mikyong] RTI Int, Atlanta, GA USA.
RP Rasmussen, SA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,MS E-86, Atlanta, GA 30333 USA.
EM skr9@cdc.gov
NR 34
TC 5
Z9 5
U1 3
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JUN
PY 2011
VL 155A
IS 6
BP 1258
EP 1263
DI 10.1002/ajmg.a.34039
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 781OV
UT WOS:000291944200007
PM 21574247
ER
PT J
AU Jamieson, DJ
Rasmussen, SA
Uyeki, TM
Weinbaum, C
AF Jamieson, Denise J.
Rasmussen, Sonja A.
Uyeki, Timothy M.
Weinbaum, Cindy
TI Pandemic influenza and pregnancy revisited: lessons learned from 2009
pandemic influenza A (H1N1)
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
ID UNITED-STATES; WOMEN; VACCINATION; CALIFORNIA; INFECTION; ILLNESS;
IMPACT
C1 [Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
[Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Uyeki, Timothy M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Weinbaum, Cindy] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
RP Jamieson, DJ (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
FU Centers for Disease Control and Prevention; Association of Maternal and
Child Health Programs
FX Publication of this article was supported by the Centers for Disease
Control and Prevention and the Association of Maternal and Child Health
Programs.
NR 38
TC 7
Z9 7
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUN
PY 2011
VL 204
IS 6
SU 1
BP S1
EP S3
DI 10.1016/j.ajog.2011.04.010
PG 3
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 772AF
UT WOS:000291201100001
PM 21640228
ER
PT J
AU Mathieu, E
Dorkenoo, A
Otogbe, FKJ
Budge, PJ
Sodahlon, YK
AF Mathieu, Els
Dorkenoo, Ameyo
Otogbe, Felix K. J.
Budge, Philip J.
Sodahlon, Yao K.
TI A Laboratory-Based Surveillance System for Wuchereria bancrofti in Togo:
A Practical Model for Resource-Poor Settings
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID LYMPHATIC FILARIASIS
AB One goal of the Global Program to Eliminate Lymphatic Filariasis (GAELF) is interruption of disease transmission through annual mass drug administration (MDA) in areas where LF prevalence is greater than 1%. After MDAs are completed, the World Health Organization (WHO) recommends a period of passive surveillance before final certification of LF elimination is achieved. Guidelines for such a surveillance system have yet to be developed. This paper describes a surveillance system launched in Togo in 2006. The system uses existing laboratories with technicians on call at night who, among other activities, prepare nocturnal thick blood smears for malaria diagnosis that can also be used for LF diagnosis. During its first 2 years (2006-2007), the system provided geographically disperse sampling nationwide, and 1 of 750 people residing in Togo was tested. Over the same period, the system detected two cases of LF, both from areas previously considered non-endemic. This system could be a cost-effective, sustainable model for WHO-mandated passive surveillance after cessation of MDA.
C1 [Mathieu, Els; Budge, Philip J.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Natl Ctr Global Hlth, Atlanta, GA 30341 USA.
[Dorkenoo, Ameyo; Otogbe, Felix K. J.] Minist Sante, Lome, Togo.
[Budge, Philip J.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30341 USA.
[Sodahlon, Yao K.] Mectizan Donat Program, Atlanta, GA USA.
RP Mathieu, E (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Natl Ctr Global Hlth, 4770 Buford Highway NE,Mail Stop F-22, Atlanta, GA 30341 USA.
EM emm7@cdc.gov; monicadork@yahoo.fr; otogbekof@yahoo.fr; pbudge@cdc.gov;
ysodahlon@taskforce.org
FU GlaxoSmithKline; Liverpool Lymphatic Filariasis Support Center; Centers
for Disease Control and Prevention
FX We would like to thank all the lab technicians who participated in this
pilot surveillance system. We would like to thank GlaxoSmithKline,
Liverpool Lymphatic Filariasis Support Center, and Centers for Disease
Control and Prevention for financing the study.
NR 20
TC 9
Z9 9
U1 0
U2 2
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD JUN
PY 2011
VL 84
IS 6
BP 988
EP 993
DI 10.4269/ajtmh.2011.10-0610
PG 6
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 773TI
UT WOS:000291333200024
PM 21633038
ER
PT J
AU Furner, SE
Hootman, JM
Helmick, CG
Bolen, J
Zack, MM
AF Furner, Sylvia E.
Hootman, Jennifer M.
Helmick, Charles G.
Bolen, Julie
Zack, Matthew M.
TI Health-Related Quality of Life of US Adults With Arthritis: Analysis of
Data From the Behavioral Risk Factor Surveillance System, 2003, 2005,
and 2007
SO ARTHRITIS CARE & RESEARCH
LA English
DT Article
ID OLDER-ADULTS; PHYSICAL-ACTIVITY; CASE-DEFINITION; INTERVENTIONS;
RELIABILITY; PROGRAM; DISEASE
AB Objective. To describe the health-related quality of life (HRQOL) of persons with and without arthritis in the 50 US states and the District of Columbia, and to determine correlates of poor HRQOL in persons with arthritis.
Methods. Data from the Behavioral Risk Factor Surveillance System were used. Descriptive analyses were age standardized and multivariate analyses used logistic regression.
Results. Of persons ages >= 18 years with arthritis, 27% reported fair/poor health, compared to 12% without arthritis. The mean numbers of physically unhealthy, mentally unhealthy, and activity-limited days for persons with arthritis exceeded those for persons without arthritis. In regression analyses, black non-Hispanics reported better HRQOL than white non-Hispanics, especially in the >= 14 versus 0 days comparisons. Yet no difference existed in self-reported health status between these two groups. Having a low family income and being unable to work were both strongly associated with poor HRQOL. Being physically active was associated with better HRQOL. Binge drinking was associated with poor HRQOL for some measures, but was associated with better self-reported health. Cost being a barrier to care and having diabetes mellitus were strongly associated with worse HRQOL.
Conclusion. Adults from the US with arthritis had worse HRQOL than those without. Physical health and mental health were both affected by arthritis; therefore, efforts to alleviate the arthritis burden should address both domains. Given the current and projected high prevalence of arthritis, we face a significant burden of poor HRQOL. Increasing physical activity, reducing comorbidities, and increasing access to health care could improve the HRQOL of persons with arthritis.
C1 [Furner, Sylvia E.] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL 60612 USA.
[Furner, Sylvia E.; Hootman, Jennifer M.; Helmick, Charles G.; Bolen, Julie; Zack, Matthew M.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Furner, SE (reprint author), Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, 1603 W Taylor,Room 951, Chicago, IL 60612 USA.
EM sefurner@uic.edu
NR 37
TC 26
Z9 28
U1 1
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2151-464X
J9 ARTHRIT CARE RES
JI Arthritis Care Res.
PD JUN
PY 2011
VL 63
IS 6
BP 788
EP 799
DI 10.1002/acr.20430
PG 12
WC Rheumatology
SC Rheumatology
GA 781EH
UT WOS:000291912900003
PM 21538946
ER
PT J
AU MacDorman, M
Declercq, E
Menacker, F
AF MacDorman, Marian
Declercq, Eugene
Menacker, Fay
TI Recent Trends and Patterns in Cesarean and Vaginal Birth After Cesarean
(VBAC) Deliveries in the United States
SO CLINICS IN PERINATOLOGY
LA English
DT Article
DE Cesarean delivery; Primary cesarean; Vaginal birth after cesarean; VBAC;
United States; International comparisons
ID SECTION; LABOR; OUTCOMES; RATES; MULTICENTER; TRIAL; WOMEN; RISK
AB Cesarean delivery is the most common major surgical procedure for women in the United States, with 1.4 million surgeries annually. In 2008, nearly one-third (32.3%) of US births were by cesarean delivery. Cesarean delivery rates have increased rapidly in the United States in recent years because of an increasing primary cesarean delivery rate and a declining vaginal birth after cesarean (VBAC) rate. In 2007, the VBAC rate was 8.3% in a 22-state reporting area. The US VBAC rate was lowest among 14 industrialized countries; 3 countries had VBAC rates greater than 50%.
C1 [MacDorman, Marian] Ctr Dis Control & Prevent, Div Vital Stat, Reprod Stat Branch, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
[Declercq, Eugene] Boston Univ, Sch Publ Hlth, Dept Community Hlth Sci, Boston, MA 02118 USA.
[Menacker, Fay] Social & Sci Syst Inc, Silver Spring, MD 20910 USA.
RP MacDorman, M (reprint author), Ctr Dis Control & Prevent, Div Vital Stat, Reprod Stat Branch, Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 7318, Hyattsville, MD 20782 USA.
EM mfm1@cdc.gov
OI Declercq, Eugene/0000-0001-5411-3033
NR 29
TC 54
Z9 55
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0095-5108
J9 CLIN PERINATOL
JI Clin. Perinatol.
PD JUN
PY 2011
VL 38
IS 2
BP 179
EP +
DI 10.1016/j.clp.2011.03.007
PG 15
WC Obstetrics & Gynecology; Pediatrics
SC Obstetrics & Gynecology; Pediatrics
GA 784PR
UT WOS:000292169700003
PM 21645788
ER
PT J
AU Lerner, EB
Cone, DC
Weinstein, ES
Schwartz, RB
Coule, PL
Cronin, M
Wedmore, IS
Bulger, EM
Mulligan, DA
Swienton, RE
Sasser, SM
Shah, UA
Weireter, LJ
Sanddal, TL
Lairet, J
Markenson, D
Romig, L
Lord, G
Salomone, J
O'Connor, R
Hunt, RC
AF Lerner, E. Brooke
Cone, David C.
Weinstein, Eric S.
Schwartz, Richard B.
Coule, Phillip L.
Cronin, Michael
Wedmore, Ian S.
Bulger, Eileen M.
Mulligan, Deborah Ann
Swienton, Raymond E.
Sasser, Scott M.
Shah, Umair A.
Weireter, Leonard J., Jr.
Sanddal, Teri L.
Lairet, Julio
Markenson, David
Romig, Lou
Lord, Gregg
Salomone, Jeffrey
O'Connor, Robert
Hunt, Richard C.
TI Mass Casualty Triage: An Evaluation of the Science and Refinement of a
National Guideline
SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
LA English
DT Article
DE Model Uniform Core Criteria for Mass Casualty Triage; triage;
guidelines; responders; SALT Triage
ID SUBWAY SARIN ATTACK; GLASGOW COMA SCALE; MAJOR LIMB TRAUMA;
PERSIAN-GULF-WAR; LIFESAVING INTERVENTIONS; DISASTER MANAGEMENT;
EMERGENCY-MEDICINE; PREHOSPITAL INDEX; TOURNIQUET USE; FIELD TRIAGE
AB Mass casualty triage is the process of prioritizing multiple victims when resources are not sufficient to treat everyone immediately. No national guideline for mass casualty triage exists in the United States. The lack of a national guideline has resulted in variability in triage processes, tags, and nomenclature. This variability has the potential to inject confusion and miscommunication into the disaster incident, particularly when multiple jurisdictions are involved. The Model Uniform Core Criteria for Mass Casualty Triage were developed to be a national guideline for mass casualty triage to ensure interoperability and standardization when responding to a mass casualty incident. The Core Criteria consist of 4 categories: general considerations, global sorting, lifesaving interventions, and individual assessment of triage category. The criteria within each of these categories were developed by a workgroup of experts representing national stakeholder organizations who used the best available science and, when necessary, consensus opinion. This article describes how the Model Uniform Core Criteria for Mass Casualty Triage were developed. (Disaster Med Public Health Preparedness. 2011; 5: 129-137)
C1 [Lerner, E. Brooke] Med Coll Wisconsin, Dept Emergency Med, Milwaukee, WI 53226 USA.
[Cone, David C.] Yale Univ, Dept Emergency Med, New Haven, CT 06520 USA.
[Weinstein, Eric S.] Amer Coll Emergency Phys & Carolinas Hosp Syst, Florence, SC USA.
[Schwartz, Richard B.; Coule, Phillip L.] Med Coll Georgia, Dept Emergency Med, Augusta, GA 30912 USA.
[Cronin, Michael] Amer Trauma Soc, Upper Marlboro, MD USA.
[Wedmore, Ian S.] US Army Surgeon Gen, Tacoma, WA USA.
[Bulger, Eileen M.] Univ Washington, Dept Surg, Seattle, WA 98195 USA.
[Mulligan, Deborah Ann] Nova SE Univ, Ctr Bioterrorism & All Hazards Preparedness, Ft Lauderdale, FL 33314 USA.
[Swienton, Raymond E.] Univ Texas SW, Dept Surg & Emergency Med, Dallas, TX USA.
[Sasser, Scott M.; Hunt, Richard C.] Ctr Dis Control & Prevent, Div Injury Response, Natl Ctr Injury Prevent & Control, Atlanta, GA USA.
[Shah, Umair A.] Harris Cty Publ Hlth & Environm Serv, Houston, TX USA.
[Weireter, Leonard J., Jr.] Eastern Virginia Med Sch, Dept Surg, Norfolk, VA USA.
[Sanddal, Teri L.] Crit Illness & Trauma Fdn Inc, Bozeman, MT USA.
[Lairet, Julio] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA.
[Markenson, David] New York Med Coll, Ctr Disaster Med, Valhalla, NY 10595 USA.
[Romig, Lou] Miami Childrens Hosp, Div Pediat Emergency Med, Miami, FL USA.
[Lord, Gregg] Natl Commiss Children & Disasters, Washington, DC USA.
[Salomone, Jeffrey] Emory Univ, Dept Surg, Sch Med, Atlanta, GA 30322 USA.
[O'Connor, Robert] Univ Virginia Hlth Syst, Dept Emergency Med, Charlottesville, VA USA.
RP Lerner, EB (reprint author), Med Coll Wisconsin, Dept Emergency Med, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
EM eblerner@mcw.edu
OI Cone, David/0000-0002-7437-959X
FU Department of Health and Human Services, Centers for Disease Control and
Prevention [02195, U17CE001232]; Centers for Disease Control and
Prevention [R49/CE001175]
FX The study was supported by the Department of Health and Human Services,
Centers for Disease Control and Prevention, Program 02195, "Terrorism
Injuries: Information Dissemination and Exchange," Award No.
U17CE001232. Dr Lerner was also partially supported by Centers for
Disease Control and Prevention Grant R49/CE001175.
NR 60
TC 17
Z9 18
U1 0
U2 13
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 1935-7893
J9 DISASTER MED PUBLIC
JI Dis. Med. Public Health Prep.
PD JUN
PY 2011
VL 5
IS 2
BP 129
EP 137
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 778SL
UT WOS:000291725800009
PM 21685309
ER
PT J
AU Keim, ME
AF Keim, Mark E.
TI Preventing Disasters: Public Health Vulnerability Reduction as a
Sustainable Adaptation to Climate Change
SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
LA English
DT Article
DE climate change; disaster management; risk reduction; adaptation;
sustainable development; human vulnerability
ID NATURAL DISASTERS; RISK; PREPAREDNESS; MANAGEMENT
AB Global warming could increase the number and severity of extreme weather events. These events are often known to result in public health disasters, but we can lessen the effects of these disasters. By addressing the factors that cause changes in climate, we can mitigate the effects of climate change. By addressing the factors that make society vulnerable to the effects of climate, we can adapt to climate change. To adapt to climate change, a comprehensive approach to disaster risk reduction has been proposed. By reducing human vulnerability to disasters, we can lessen-and at times even prevent-their impact.
Human vulnerability is a complex phenomenon that comprises social, economic, health, and cultural factors. Because public health is uniquely placed at the community level, it has the opportunity to lessen human vulnerability to climate-related disasters. At the national and international level, a supportive policy environment can enable local adaptation to disaster events. The purpose of this article is to introduce the basic concept of disaster risk reduction so that it can be applied to preventing and mitigating the negative effects of climate change and to examine the role of community-focused public health as a means for lessening human vulnerability and, as a result, the overall risk of climate-related disasters. (Disaster Med Public Health Preparedness. 2011; 5: 140-148)
C1 Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Agcy Toxic Subst & Dis Registry, Atlanta, GA 30341 USA.
RP Keim, ME (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Agcy Toxic Subst & Dis Registry, 4770 Buford Hwy,MS F09, Atlanta, GA 30341 USA.
EM mjk9@cdc.gov
RI Ahluwalia, Tarun/A-2762-2012; Brooks, Katya/J-4975-2014
FU Centers for Disease Control and Prevention, Coordinating Office for
Terrorism Preparedness and Emergency Response
FX This work was supported by funds made available by the Centers for
Disease Control and Prevention, Coordinating Office for Terrorism
Preparedness and Emergency Response. The material in this article
reflects solely the views of the author and not necessarily the policies
or recommendations of the Centers for Disease Control and Prevention or
the US Department of Health and Human Services.
NR 53
TC 7
Z9 7
U1 2
U2 17
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 1935-7893
J9 DISASTER MED PUBLIC
JI Dis. Med. Public Health Prep.
PD JUN
PY 2011
VL 5
IS 2
BP 140
EP 148
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 778SL
UT WOS:000291725800010
PM 21402799
ER
PT J
AU Safran, MA
Chorba, T
Schreiber, M
Archer, WR
Cookson, ST
AF Safran, Marc A.
Chorba, Terence
Schreiber, Merritt
Archer, W. Roodly
Cookson, Susan T.
TI Evaluating Mental Health After the 2010 Haitian Earthquake
SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
LA English
DT Article
DE disaster; public health; mental health
ID POSTTRAUMATIC-STRESS-DISORDER; PART
AB Mental health is an important aspect of public health after a disaster. This article describes what is known and what remains to be learned regarding the mental health impact of the January 12, 2010, earthquake in Haiti. Public health surveillance efforts in Haiti and the United States in the first 2 months after the earthquake are described. Challenges in clinical assessment and public health surveillance are explored. Potential implications for survivors and public health officials are considered. (Disaster Med Public Health Preparedness. 2011; 5: 154-157)
C1 [Safran, Marc A.] CDC, US Publ Hlth Serv, Atlanta, GA 30333 USA.
[Chorba, Terence] CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
[Schreiber, Merritt] Amer Red Cross, Washington, DC 20006 USA.
RP Safran, MA (reprint author), Ctr Dis Control & Prevent, Mail Stop E-44,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM MSafran@cdc.gov
NR 24
TC 7
Z9 7
U1 1
U2 14
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 1935-7893
J9 DISASTER MED PUBLIC
JI Dis. Med. Public Health Prep.
PD JUN
PY 2011
VL 5
IS 2
BP 154
EP 157
PG 4
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 778SL
UT WOS:000291725800012
PM 21444734
ER
PT J
AU Jeon, HJ
Peterson, CA
Wall, S
Carta, JJ
Luze, G
Eshbaugh, EM
Swanson, M
AF Jeon, Hyun-Joo
Peterson, Carla A.
Wall, Shavaun
Carta, Judith J.
Luze, Gayle
Eshbaugh, Elaine M.
Swanson, Mark
TI Predicting School Readiness for Low-Income Children With Disability
Risks Identified Early
SO EXCEPTIONAL CHILDREN
LA English
DT Article
ID EARLY HEAD-START; EARLY INTERVENTION; PRESCHOOL-CHILDREN;
YOUNG-CHILDREN; DEVELOPMENTAL DELAYS; CHILDHOOD POVERTY; OUTCOMES;
SKILLS; CARE; COMMUNICATION
AB This study examined school readiness at kindergarten entry for low-income children whose disability indicators were identified before age 3. Data were collected as part of the Early Head Start Research and Evaluation Longitudinal Follow-Up study. Children who had suspected developmental delays and did not receive Part C services had lower preacademic skill scores at kindergarten entry than those who had no disability indicators. In contrast, the preacademic skills at age 5 of children who received Part C services did not differ from those who had no disability indicators. A large proportion of children who had suspected developmental delays and did not receive Part C services by age 3 received Part B services later. Results highlight the importance of early intervention for low-income children who have suspected developmental delays to enhance their school readiness skills.
C1 [Jeon, Hyun-Joo] Univ Alabama, Dept Human Dev & Family Studies, Tuscaloosa, AL 35487 USA.
[Peterson, Carla A.; Luze, Gayle] Iowa State Univ, Dept Human Dev & Family Studies, Ames, IA USA.
[Wall, Shavaun] Catholic Univ Amer, Dept Educ, Washington, DC 20064 USA.
[Carta, Judith J.] Univ Kansas, Juniper Gardens Childrens Project, Kansas City, KS USA.
[Eshbaugh, Elaine M.] Univ No Iowa, Dept Psychol, Cedar Falls, IA 50614 USA.
[Swanson, Mark] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Jeon, HJ (reprint author), Univ Alabama, Dept Human Dev & Family Studies, Box 870160, Tuscaloosa, AL 35487 USA.
EM jeon@ches.ua.edu
NR 56
TC 3
Z9 3
U1 1
U2 3
PU COUNCIL EXCEPTIONAL CHILDREN
PI ARLINGTON
PA 1110 N GLEBE RD, ARLINGTON, VA 22201-5704 USA
SN 0014-4029
J9 EXCEPT CHILDREN
JI Except. Child.
PD SUM
PY 2011
VL 77
IS 4
BP 435
EP 452
PG 18
WC Education, Special; Rehabilitation
SC Education & Educational Research; Rehabilitation
GA 783IS
UT WOS:000292075300005
ER
PT J
AU Ibrahimova, A
Shults, RA
Beck, LF
AF Ibrahimova, Aybaniz
Shults, Ruth A.
Beck, Laurie F.
TI Comparison of 2008 national and state-level self-reported and observed
seatbelt use estimates
SO INJURY PREVENTION
LA English
DT Article
ID VALIDITY
AB The objective of the study was to compare national and state-level estimates of self-reported and observed seatbelt use for 2008. Self-reported seatbelt use from the 2008 Behavioral Risk Factor Surveillance System was compared with 2008 observed seatbelt use published by the National Highway Traffic Safety Administration. The ratio of self-reported belt use to observed use was calculated for each state, and the correlation between the two seatbelt measures was examined using the Pearson correlation coefficient. The median state ratio of self-reported to observed belt use was 0.97. Self-reported use was lower than observed use in 38 states. A moderate association was revealed between the self-reported and observed use (r=0.71, p<0.01). The findings suggest that, as seatbelt use has increased over time, measures of self-reported and observed use have converged, and any upward bias in self-reported use due to social desirability has substantially declined.
C1 [Ibrahimova, Aybaniz; Shults, Ruth A.; Beck, Laurie F.] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA.
[Ibrahimova, Aybaniz] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA.
RP Ibrahimova, A (reprint author), Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Highway NE,MS F-62, Atlanta, GA 30333 USA.
EM gqt1@cdc.gov
NR 17
TC 7
Z9 7
U1 0
U2 1
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1353-8047
J9 INJURY PREV
JI Inj. Prev.
PD JUN
PY 2011
VL 17
IS 3
BP 201
EP 203
DI 10.1136/ip.2010.028597
PG 3
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 770NW
UT WOS:000291094700014
PM 21393414
ER
PT J
AU Signs, K
Stobierski, MG
Rupprecht, CE
Robertson, K
AF Signs, K.
Stobierski, M. G.
Rupprecht, C. E.
Robertson, K.
TI Human Rabies-Michigan, 2009 (Reprinted from MMWR, vol 60, pg 437-440,
2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Robertson, K.] CDC, EIS, Atlanta, GA 30333 USA.
[Signs, K.; Stobierski, M. G.] Natl Ctr Emerging & Zoonot Infect Dis, Michigan Dept Community Hlth, Howell, MI USA.
RP Robertson, K (reprint author), CDC, EIS, Atlanta, GA 30333 USA.
EM krobertson@cdc.gov
NR 1
TC 0
Z9 0
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JUN 1
PY 2011
VL 305
IS 21
BP 2163
EP 2165
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 770RN
UT WOS:000291106300008
ER
PT J
AU Holman, DM
Soman, A
Watson, M
Weir, HK
Trivers, KF
White, MC
AF Holman, Dawn M.
Soman, Ashwini
Watson, Meg
Weir, Hannah K.
Trivers, Katrina F.
White, Mary C.
TI Examination of the Increase in Thyroid Cancer Incidence Among Younger
Women in the United States by Age, Race, Geography, and Tumor Size,
1999-2007
SO JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
LA English
DT Article
AB Purpose: Thyroid cancer incidence has been increasing for several decades, but the reasons are not fully understood. Previous surveillance reports have covered less than 26% of the U.S. population. More recent, nationwide data are needed. This study examines thyroid cancer incidence among younger women by age, race/ethnicity, geography, and tumor size. Patients and Methods: Our study uses nationwide surveillance data to describe incidence rates and recent trends in thyroid cancer among adults aged 20-39 years in the United States during 1999-2007, with a focus on females. Results: Incidence rates were more than five times higher among females (16.4 per 100,000; 95% confidence interval [CI]: 16.2-16.6) than among males (3.1 per 100,000; 95% CI: 3.1-3.2). Among females, rates were higher among non-Hispanic whites than among other racial/ethnic groups and higher in the Northeast compared with other regions (p < 0.05). During 1999-2007, incidence rates increased 5.3% each year among females (95% CI: 4.7-5.9). This increase was observed across five-year age groups, racial/ethnic groups (except American Indians/Alaska Natives), geographic regions, and tumor sizes. Conclusion: The increase in rates across all tumor sizes suggests that the observed increases cannot be attributed solely to changes in diagnostics or surveillance. In addition, the continued increase in incidence rates in recent years among persons born after 1960 suggests that other, more contemporary factors than those previously proposed may play a contributing role.
C1 [Holman, Dawn M.; Watson, Meg; Weir, Hannah K.; Trivers, Katrina F.; White, Mary C.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30341 USA.
[Soman, Ashwini] Northrop Grumman Corp, Atlanta, GA USA.
RP Holman, DM (reprint author), Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, 4770 Buford Hwy MS K55, Atlanta, GA 30341 USA.
EM isc6@cdc.gov
RI White, Mary C./C-9242-2012
OI White, Mary C./0000-0002-9826-3962
FU U.S. Department of Energy; Centers for Disease Control and Prevention
FX This research was supported in part by an appointment (Dawn M. Holman)
to the Research Participation Program at the Centers for Disease Control
and Prevention administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the U.S. Department
of Energy and the Centers for Disease Control and Prevention. The
findings and conclusions in this report are those of the authors and do
not necessarily represent the official position of the Centers for
Disease Control and Prevention.
NR 63
TC 3
Z9 3
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2156-5333
EI 2156-535X
J9 J ADOLESC YOUNG ADUL
JI J. Adolesc. Young Adult Oncol.
PD JUN
PY 2011
VL 1
IS 2
BP 95
EP 102
DI 10.1089/jayao.2011.0014
PG 8
WC Oncology
SC Oncology
GA V39IF
UT WOS:000209404000005
PM 26812631
ER
PT J
AU Brown, HE
Doyle, MS
Cox, J
Eisen, RJ
Nasci, RS
AF Brown, Heidi E.
Doyle, Michael S.
Cox, Jonathan
Eisen, Rebecca J.
Nasci, Roger S.
TI THE EFFECT OF SPATIAL AND TEMPORAL SUBSETTING ON CULEX TARSALIS
ABUNDANCE MODELS-A DESIGN FOR SENSIBLE REDUCTION OF VECTOR SURVEILLANCE
SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION
LA English
DT Article
DE Culex tarsalis; autoregressive; time series; mosquito; surveillance;
West Nile Virus
ID WEST-NILE-VIRUS; TIME-SERIES ANALYSIS; MOSQUITO ABUNDANCE; COACHELLA
VALLEY; TRANSMISSION; CALIFORNIA; EPIDEMIOLOGY; DISEASE; CONNECTICUT;
SELECTION
AB Early identification of increasing mosquito activity is critical to effective mosquito control, particularly when increasing host-seeking behavior may be associated with increased risk of mosquito-borne disease. In this paper, we analyzed the temporal abundance pattern of the West Nile Virus vector, Culex tarsalis, in Fort Collins, CO, using an autoregressive integrated moving average model. We determined that an autoregressive model order 5 with lagged minimum temperatures was best at describing the seasonal abundance of Cx. tarsalis. We then tested the effect of using both temporal and spatial subsets of the data to determine the effect of reduced sampling effort on abundance predictions. We found that, if reduced trapping is necessary due to limited resources, removal of the least productive 1/3 or 1/4 of the traps produced the least erroneous predictions of seasonality represented in the observed data. We show that this productivity-based subset scheme performs better than other sampling effort reductions in generating the best estimate of Cx. tarsalis abundance per trap-night.
C1 [Brown, Heidi E.; Doyle, Michael S.; Eisen, Rebecca J.; Nasci, Roger S.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA.
[Cox, Jonathan] SW Fdn Biomed Res, Dept Virol & Immunol, San Antonio, TX 78227 USA.
RP Brown, HE (reprint author), Univ Arizona, Sch Geog & Dev, 1103 E 2nd St,Harvill Room 405, Tucson, AZ 85721 USA.
OI Brown, Heidi/0000-0001-8578-5510
NR 29
TC 2
Z9 2
U1 0
U2 6
PU AMER MOSQUITO CONTROL ASSOC
PI MOUNT LAUREL
PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA
SN 8756-971X
J9 J AM MOSQUITO CONTR
JI J. Am. Mosq. Control Assoc.
PD JUN
PY 2011
VL 27
IS 2
BP 120
EP 128
DI 10.2987/10-6077.1
PG 9
WC Entomology
SC Entomology
GA 973FH
UT WOS:000306343700005
PM 21805843
ER
PT J
AU Comer, JA
Calisher, CH
AF Comer, James A.
Calisher, Charles H.
TI WILLIAM DANIEL SUDIA 1922-2010 OBITUARY
SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION
LA English
DT Biographical-Item
C1 [Comer, James A.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA.
[Calisher, Charles H.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA.
RP Comer, JA (reprint author), Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU AMER MOSQUITO CONTROL ASSOC
PI MOUNT LAUREL
PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA
SN 8756-971X
J9 J AM MOSQUITO CONTR
JI J. Am. Mosq. Control Assoc.
PD JUN
PY 2011
VL 27
IS 2
BP 177
EP 179
DI 10.2987/8756-971X-27.2.177
PG 3
WC Entomology
SC Entomology
GA 973FH
UT WOS:000306343700019
ER
PT J
AU Shah, NS
Shiraishi, RW
Subhachaturas, W
Anand, A
Whitehead, SJ
Tanpradech, S
Manopaiboon, C
Sabin, KM
Fox, KK
Kim, AY
AF Shah, Neha S.
Shiraishi, Ray W.
Subhachaturas, Wonchart
Anand, Abhijeet
Whitehead, Sara J.
Tanpradech, Suvimon
Manopaiboon, Chomnad
Sabin, Keith M.
Fox, Kimberley K.
Kim, Andrea Y.
TI Bridging Populations-Sexual Risk Behaviors and HIV Prevalence in Clients
and Partners of Female Sex Workers, Bangkok, Thailand 2007
SO JOURNAL OF URBAN HEALTH-BULLETIN OF THE NEW YORK ACADEMY OF MEDICINE
LA English
DT Article
DE Female sex workers; Thailand; Bridge population; Male clients; HIV
ID INJECTION-DRUG USERS; HIDDEN POPULATIONS; TRANSMITTED-DISEASES; CONDOM
USE; MEN; PROSTITUTES; PROGRAM; SEROPREVALENCE; PREVENTION; INFECTION
AB The aim of this study is to estimate HIV prevalence and assess sexual behaviors in a high-risk and difficult-to-reach population of clients of female sex workers (FSWs). A modified variation of respondent-driven sampling was conducted among FSWs in Bangkok, where FSWs recruited 3 FSW peers, 1 client, and 1 nonpaying partner. After informed consent was obtained, participants completed a questionnaire, were HIV-tested, and were asked to return for results. Analyses were weighted to control for the design of the survey. Among 540 FSWs, 188 (35%) recruited 1 client, and 88 (16%) recruited 1 nonpaying partner. Clients' median age was 38 years. HIV prevalence was 20% and was associated with younger age at first sexual experience [relative risk (RR) = 3.10, 95% confidence interval (CI) 1.16-8.24] and condom use during last sexual encounter with regular partner (RR = 3.97, 95% CI 1.09-14.61). Median age of nonpaying partners was 34 years, and HIV prevalence was 15.1%. There were 56 discordant FSW-client pairs and 14 discordant FSW-nonpaying partner pairs. Condom use was relatively high among discordant FSW-client pairs (90.1%) compared to discordant FSW-nonpaying partner pairs (18.7%). Results suggest that sexual partners of FSWs have a high HIV prevalence and can be a bridge for HIV transmission to other populations. Findings also highlight the importance of initiating surveillance and targeted programs for FSW partners, and demonstrate a recruitment method for hard-to-reach populations.
C1 [Shah, Neha S.; Shiraishi, Ray W.; Anand, Abhijeet; Whitehead, Sara J.; Sabin, Keith M.; Fox, Kimberley K.; Kim, Andrea Y.] Ctr Dis Control & Prevent, Global AIDS Program, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA.
[Subhachaturas, Wonchart] Bangkok Metropolitan Adm, Bangkok, Thailand.
[Whitehead, Sara J.; Tanpradech, Suvimon; Fox, Kimberley K.] Thailand MOPH US Ctr Dis Control & Prevent Collab, Bangkok, Thailand.
RP Shah, NS (reprint author), Ctr Dis Control & Prevent, Global AIDS Program, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA.
EM Nshah6@cdc.gov
OI Sabin, Keith/0000-0002-2290-8621
FU Epidemic Intelligence Service Program in Atlanta, United States;
Emergency Plan for AIDS Relief in Atlanta, USA; Bangkok Metropolitan
Administration, Bangkok, Thailand; Thailand Ministry of Public Health-US
Centers for Disease Control and Prevention Collaboration, Bangkok
FX The authors thank all those who participated in the study, the local
organizations that assisted with the study enrollment and data
collection, and the Thailand Ministry of Health. The authors are also
thankful to Douglas Heckathorn and Matt Salganik who provided guidance
for data analysis, Lisa Johnston who conducted the RDS training, and
Dana Dolan who helped with editing the manuscript. Support for this
analysis was provided by the Epidemic Intelligence Service Program in
Atlanta, United States, the President's Emergency Plan for AIDS Relief
in Atlanta, USA, the Bangkok Metropolitan Administration, Bangkok,
Thailand, and the Thailand Ministry of Public Health-US Centers for
Disease Control and Prevention Collaboration, Bangkok.
NR 45
TC 12
Z9 13
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1099-3460
J9 J URBAN HEALTH
JI J. Urban Health
PD JUN
PY 2011
VL 88
IS 3
BP 533
EP 544
DI 10.1007/s11524-010-9542-5
PG 12
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 786AN
UT WOS:000292274600012
PM 21336505
ER
PT J
AU Dong, XQ
Simon, MA
Fulmer, T
de Leon, CFM
Hebert, LE
Beck, T
Scherr, PA
Evans, DA
AF Dong, XinQi
Simon, Melissa A.
Fulmer, Terry
de Leon, Carlos F. Mendes
Hebert, Liesi E.
Beck, Todd
Scherr, Paul A.
Evans, Denis A.
TI A Prospective Population-Based Study of Differences in Elder
Self-Neglect and Mortality Between Black and White Older Adults
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
SCIENCES
LA English
DT Article
DE Self-neglect; Health disparity; Population-based study; Race/ethnicity;
Mortality
ID COMMUNITY-DWELLING POPULATION; PHYSICAL PERFORMANCE; COGNITIVE FUNCTION;
HEALTH; RISK; CARE; DISABILITY; INEQUALITY; AMERICANS; DECLINE
AB Background. Self-neglect is the behavior of an elderly person that threatens his or her own health and safety, and it is associated with increased morbidity and mortality. Although report of self-neglect is more common among black older adults, the racial/ethnic differences in mortality remain unclear.
Methods. The Chicago Healthy Aging Project is a population-based cohort study conducted from 1993 to 2005. A subset of these participants were suspected to self-neglect and were reported to a social services agency. Mortality was ascertained during follow-up and from the National Death Index. Cox proportional hazards models were used to assess the mortality risk.
Results. In the total cohort, there were 5,963 black and 3,475 white older adults, and of these, 1,479 were reported for self-neglect (21.7% in black and 5.3% in white older adults). In multivariable analyses with extensive adjustments, the interaction term indicated that impact of self-neglect on mortality was significantly stronger in black than in white older adults (parameter estimate, 0.54, SE, 0.14, p <.001). This difference persisted over time. In race/ethnicity-stratified analyses, at 6 months after report of self-neglect, the hazard ratio for black older adults was 5.00 (95% confidence interval, 4.47-5.59) and for white older adults was 2.75 (95% confidence interval, 2.19-3.44). At 3 years after report, the hazard ratios were 2.61 (95% confidence interval, 2.25-3.04) and 1.47 (95% confidence interval, 1.10-1.96) for black older adults and white older adults, respectively.
Conclusions. Future studies are needed to qualify the casual mechanisms between self-neglect and mortality in black and white older adults in order to devise targeted prevention and intervention strategies.
C1 [Dong, XinQi; de Leon, Carlos F. Mendes; Hebert, Liesi E.; Beck, Todd; Evans, Denis A.] Rush Univ, Med Ctr, Rush Inst Hlth Aging, Chicago, IL 60612 USA.
[Simon, Melissa A.] Northwestern Univ, Med Ctr, Dept Obstet Gynecol, Chicago, IL 60611 USA.
[Fulmer, Terry] NYU, Coll Nursing, New York, NY 10003 USA.
[Scherr, Paul A.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Simon, Melissa A.] Northwestern Univ, Med Ctr, Buehler Ctr Agin, Chicago, IL 60611 USA.
RP Dong, XQ (reprint author), Rush Univ, Med Ctr, Rush Inst Hlth Aging, 1645 W Jackson,Suite 675, Chicago, IL 60612 USA.
EM xinqi_dong@rush.edu
FU National Institute on Aging [R01 AG11101]; American Federation for Aging
Research [K23 AG030944]; Starr Foundation; John A. Hartford Foundation;
Atlantic Philanthropies
FX This work was supported by National Institute on Aging (R01 AG11101),
Paul B. Beeson Career Development Award in Aging (K23 AG030944),
American Federation for Aging Research, The Starr Foundation, John A.
Hartford Foundation, and The Atlantic Philanthropies.
NR 52
TC 17
Z9 19
U1 1
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD JUN
PY 2011
VL 66
IS 6
BP 695
EP 704
DI 10.1093/gerona/glr053
PG 10
WC Geriatrics & Gerontology; Gerontology
SC Geriatrics & Gerontology
GA 780XA
UT WOS:000291892900013
PM 21498840
ER
PT J
AU Holman, DM
White, MC
AF Holman, Dawn M.
White, Mary C.
TI Dietary behaviors related to cancer prevention among pre-adolescents and
adolescents: the gap between recommendations and reality
SO NUTRITION JOURNAL
LA English
DT Review
ID BODY-MASS INDEX; BREAST-CANCER; NUTRITION; CHILDREN; RISK; ADULTHOOD;
OBESITY; FRUIT; OVERWEIGHT; CHILDHOOD
AB Background: Diet is thought to play an important role in cancer risk. This paper summarizes dietary recommendations for cancer prevention and compares these recommendations to the dietary behaviors of U. S. youth ages 8-18.
Methods: We identified cancer prevention-related dietary recommendations from key health organizations and assessed dietary consumption patterns among youth using published statistics from the National Health and Nutrition Examination Survey, the national Youth Risk Behavior Survey, and other supplemental sources.
Results: Cancer prevention guidelines recommend a diet rich in fruits, vegetables, and whole grains, recommend limiting sugary foods and beverages, red and processed meats, sodium, and alcohol, and recommend avoiding foods contaminated with carcinogens. However, youth typically do not meet the daily recommendations for fruit, vegetable, or whole grain consumption and are over-consuming energy-dense, sugary and salty foods.
Conclusions: A large discrepancy exists between expert recommendations about diet and cancer and actual dietary practices among young people and points to the need for more research to better promote the translation of science into practice. Future research should focus on developing and evaluating policies and interventions at the community, state and national levels for aligning the diets of youth with the evolving scientific evidence regarding cancer prevention.
C1 [Holman, Dawn M.; White, Mary C.] Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, Atlanta, GA 30341 USA.
RP Holman, DM (reprint author), Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, 4770 Buford Highway NE,Mailstop K-55, Atlanta, GA 30341 USA.
EM isc6@cdc.gov
RI White, Mary /C-9242-2012
OI White, Mary /0000-0002-9826-3962
FU Centers for Disease Control
FX This research was supported in part by an appointment (DMH) to the
Research Participation Program at the Centers for Disease Control and
Prevention administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the U. S. Department
of Energy and CDC. We would like to thank Lori A. (Loria) Pollack, MD,
MPH in the Division of Cancer Prevention and Control, CDC, for her
helpful comments and contributions to earlier drafts of this manuscript.
The findings and conclusions in this report are those of the authors and
do not necessarily represent the official position of the Centers for
Disease Control and Prevention.
NR 66
TC 20
Z9 20
U1 1
U2 13
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2891
J9 NUTR J
JI Nutr. J.
PD JUN 1
PY 2011
VL 10
AR 60
DI 10.1186/1475-2891-10-60
PG 8
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 785BP
UT WOS:000292202700001
PM 21631948
ER
PT J
AU Atun, R
Branson, B
Burns, D
Calleja, JMG
Busch, M
Constestable, P
Dallabetta, G
Domingo, G
Goosby, AE
Garrett, P
Ghys, P
Gilbreath, M
Hallett, T
Hirnschall, G
Holmes, C
Kaldor, J
Kim, A
Laeyendecker, O
Mermin, J
McWalter, T
Mink, R
Murphy, G
Murtagh, M
Owen, SM
Padian, N
Parekh, B
Piot, P
Quinn, T
Ridzon, R
Rodriguez, B
Rousseau, C
Schito, M
Sexton, C
Sharma, U
Welte, A
Wong, A
AF Atun, Rifat
Branson, Bernard
Burns, David
Garcia Calleja, Jesus Maria
Busch, Mike
Constestable, Paul
Dallabetta, Gina
Domingo, Gonzalo
Goosby, Amb Eric
Garrett, Patricia
Ghys, Peter
Gilbreath, Michael
Hallett, Tim
Hirnschall, Gottfried
Holmes, Charles
Kaldor, John
Kim, Andrea
Laeyendecker, Oliver
Mermin, Jonathan
McWalter, Tom
Mink, Ronald
Murphy, Gary
Murtagh, Maurine
Owen, Sherry M. (Michele)
Padian, Nancy
Parekh, Bharat
Piot, Peter
Quinn, Tom
Ridzon, Renee
Rodriguez, Bill
Rousseau, Christine
Schito, Marco
Sexton, Connie
Sharma, Usha
Welte, Alex
Wong, Amy
CA Incidence Assay Critical Path Work
TI More and Better Information to Tackle HIV Epidemics: Towards Improved
HIV Incidence Assays
SO PLOS MEDICINE
LA English
DT Editorial Material
ID CAPTURE ENZYME-IMMUNOASSAY; RECENT INFECTION; AVIDITY; AFRICA; ACCURACY;
UGANDA; TESTS; GP41
C1 [Hallett, Tim; Piot, Peter] Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England.
[Branson, Bernard; Kim, Andrea; Mermin, Jonathan; Owen, Sherry M. (Michele); Parekh, Bharat; Sexton, Connie] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Burns, David; Gilbreath, Michael; Schito, Marco; Sharma, Usha] Natl Inst Hlth, Bethesda, MD USA.
[Garcia Calleja, Jesus Maria; Hirnschall, Gottfried] WHO, New York, NY USA.
[Kaldor, John] Univ New S Wales, Sydney, NSW 2052, Australia.
[Laeyendecker, Oliver; Quinn, Tom] Johns Hopkins Univ, Baltimore, MD 21218 USA.
[McWalter, Tom] Univ Witwatersrand, ZA-2050 Wits, South Africa.
RP Hallett, T (reprint author), Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England.
EM timothy.hallett@imperial.ac.uk
RI Laeyendecker, Oliver/B-9331-2009; Mermin, Jonathan/J-9847-2012; Kaldor,
John /D-4545-2011
NR 37
TC 0
Z9 0
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1549-1277
J9 PLOS MED
JI PLos Med.
PD JUN
PY 2011
VL 8
IS 6
AR e1001045
DI 10.1371/journal.pmed.1001045
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 784EC
UT WOS:000292136800009
ER
PT J
AU Luby, SP
Halder, AK
Huda, T
Unicomb, L
Johnston, RB
AF Luby, Stephen P.
Halder, Amal K.
Huda, Tarique
Unicomb, Leanne
Johnston, Richard B.
TI The Effect of Handwashing at Recommended Times with Water Alone and With
Soap on Child Diarrhea in Rural Bangladesh: An Observational Study
SO PLOS MEDICINE
LA English
DT Article
ID HYGIENE BEHAVIOR; FRESH PRODUCE; UNITED-STATES; GROWTH; OUTBREAKS;
HANDS; SALMONELLOSIS; CONTAMINATION; TEMPERATURE; REACTIVITY
AB Background: Standard public health interventions to improve hand hygiene in communities with high levels of child mortality encourage community residents to wash their hands with soap at five separate key times, a recommendation that would require mothers living in impoverished households to typically wash hands with soap more than ten times per day. We analyzed data from households that received no intervention in a large prospective project evaluation to assess the relationship between observed handwashing behavior and subsequent diarrhea.
Methods and Findings: Fieldworkers conducted a 5-hour structured observation and a cross-sectional survey in 347 households from 50 villages across rural Bangladesh in 2007. For the subsequent 2 years, a trained community resident visited each of the enrolled households every month and collected information on the occurrence of diarrhea in the preceding 48 hours among household residents under the age of 5 years. Compared with children living in households where persons prepared food without washing their hands, children living in households where the food preparer washed at least one hand with water only (odds ratio [OR] = 0.78; 95% confidence interval [CI] = 0.57-1.05), washed both hands with water only (OR = 0.67; 95% CI = 0.51-0.89), or washed at least one hand with soap (OR = 0.30; 95% CI = 0.19-0.47) had less diarrhea. In households where residents washed at least one hand with soap after defecation, children had less diarrhea (OR = 0.45; 95% CI = 0.26-0.77). There was no significant association between handwashing with or without soap before feeding a child, before eating, or after cleaning a child's anus who defecated and subsequent child diarrhea.
Conclusions: These observations suggest that handwashing before preparing food is a particularly important opportunity to prevent childhood diarrhea, and that handwashing with water alone can significantly reduce childhood diarrhea.
C1 [Luby, Stephen P.; Halder, Amal K.; Huda, Tarique; Unicomb, Leanne] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh.
[Luby, Stephen P.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Johnston, Richard B.] UNICEF Bangladesh, Water & Environm Sanitat Sect, Dhaka, Bangladesh.
RP Luby, SP (reprint author), Int Ctr Diarrhoeal Dis Res, GPO Box 128, Dhaka 1000, Bangladesh.
EM sluby@icddrb.org
FU United Kingdom Department for International Development (DFID); UNICEF
Bangladesh; Procter; Gamble Company, a global manufacturer of soap
FX This program evaluation was funded by the United Kingdom Department for
International Development (DFID) and UNICEF Bangladesh. UNICEF
Bangladesh collaborated in the study design and reviewed and provided
input on the manuscript. The first author developed the idea for the
manuscript, conducted the analysis, drafted the manuscript and made the
decision to publish.; SPL received a total of $3.2 million in research
funding for 13 research projects on handwashing and household water
treatment between 1996 and 2007 from the Procter and Gamble Company, a
global manufacturer of soap.
NR 44
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U1 0
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1549-1277
J9 PLOS MED
JI PLos Med.
PD JUN
PY 2011
VL 8
IS 6
AR e1001052
DI 10.1371/journal.pmed.1001052
PG 12
WC Medicine, General & Internal
SC General & Internal Medicine
GA 784EC
UT WOS:000292136800015
PM 21738452
ER
PT J
AU Blocher, J
Schmutzhard, E
Wilkins, PP
Gupton, PN
Schaffert, M
Auer, H
Gotwald, T
Matuja, W
Winkler, AS
AF Blocher, Joachim
Schmutzhard, Erich
Wilkins, Patricia P.
Gupton, Paige N.
Schaffert, Matthias
Auer, Herbert
Gotwald, Thaddaeus
Matuja, William
Winkler, Andrea S.
TI A Cross-Sectional Study of People with Epilepsy and Neurocysticercosis
in Tanzania: Clinical Characteristics and Diagnostic Approaches
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID LINKED IMMUNOELECTROTRANSFER BLOT; TAENIA-SOLIUM CYSTICERCOSIS;
DOOR-TO-DOOR; LATE-ONSET EPILEPSY; IMMUNOSORBENT-ASSAY; ACTIVE EPILEPSY;
RURAL TANZANIA; PREVALENCE; AFRICA; SEIZURES
AB Neurocysticercosis (NCC) is a major cause of epilepsy in regions where pigs are free-ranging and hygiene is poor. Pork production is expected to increase in the next decade in sub-Saharan Africa, hence NCC will likely become more prevalent. In this study, people with epilepsy (PWE, n = 212) were followed up 28.6 months after diagnosis of epilepsy. CT scans were performed, and serum and cerebrospinal fluid (CSF) of selected PWE were analysed. We compared the demographic data, clinical characteristics, and associated risk factors of PWE with and without NCC. PWE with NCC (n = 35) were more likely to be older at first seizure (24.3 vs. 16.3 years, p = 0.097), consumed more pork (97.1% vs. 73.6%, p = 0.001), and were more often a member of the Iraqw tribe (94.3% vs. 67.8%, p = 0.005) than PWE without NCC (n = 177). PWE and NCC who were compliant with anti-epileptic medications had a significantly higher reduction of seizures (98.6% vs. 89.2%, p = 0.046). Other characteristics such as gender, seizure frequency, compliance, past medical history, close contact with pigs, use of latrines and family history of seizures did not differ significantly between the two groups. The number of NCC lesions and active NCC lesions were significantly associated with a positive antibody result. The electroimmunotransfer blot, developed by the Centers for Disease Control and Prevention, was more sensitive than a commercial western blot, especially in PWE and cerebral calcifications. This is the first study to systematically compare the clinical characteristics of PWE due to NCC or other causes and to explore the utility of two different antibody tests for diagnosis of NCC in sub-Saharan Africa.
C1 [Blocher, Joachim; Schmutzhard, Erich; Schaffert, Matthias] Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria.
[Blocher, Joachim; Schaffert, Matthias; Winkler, Andrea S.] Haydom Lutheran Hosp, Mbulu, Manyara Region, Tanzania.
[Blocher, Joachim] Univ Med Ctr Gottingen, Dept Neurol, Gottingen, Germany.
[Wilkins, Patricia P.; Gupton, Paige N.] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Parasit Dis, Atlanta, GA USA.
[Auer, Herbert] Med Univ Vienna, Dept Med Parasitol, Inst Specif Prophylaxis & Trop Med, Vienna, Austria.
[Gotwald, Thaddaeus] Med Univ Innsbruck, Dept Radiol, Innsbruck, Austria.
[Matuja, William] Muhimbili Natl Hosp, Dept Neurol, Dar Es Salaam, Tanzania.
[Winkler, Andrea S.] Tech Univ Munich, Dept Neurol, Munich, Germany.
RP Blocher, J (reprint author), Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria.
EM joachim.blocher@med.uni-goettingen.de
FU Savoy Epilepsy Foundation, Quebec, Canada; Centre for International
Migration, Frankfurt, Germany
FX The study was supported by the Savoy Epilepsy Foundation, Quebec, Canada
and ASW was supported by the Centre for International Migration,
Frankfurt, Germany. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 44
TC 14
Z9 15
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2727
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD JUN
PY 2011
VL 5
IS 6
AR e1185
DI 10.1371/journal.pntd.0001185
PG 8
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 784EZ
UT WOS:000292139600025
PM 21666796
ER
PT J
AU MacNeil, A
Reed, Z
Rollin, PE
AF MacNeil, Adam
Reed, Zachary
Rollin, Pierre E.
TI Serologic Cross-Reactivity of Human IgM and IgG Antibodies to Five
Species of Ebola Virus
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID HEMORRHAGIC-FEVER; MARBURG VIRUSES; HUMAN INFECTION; OUTBREAK;
FILOVIRUS; GABON; CONGO; PHILIPPINES; PREVALENCE; POPULATIONS
AB Five species of Ebola virus (EBOV) have been identified, with nucleotide differences of 30-45% between species. Four of these species have been shown to cause Ebola hemorrhagic fever (EHF) in humans and a fifth species (Reston ebolavirus) is capable of causing a similar disease in non-human primates. While examining potential serologic cross-reactivity between EBOV species is important for diagnostic assays as well as putative vaccines, the nature of cross-reactive antibodies following EBOV infection has not been thoroughly characterized. In order to examine cross-reactivity of human serologic responses to EBOV, we developed antigen preparations for all five EBOV species, and compared serologic responses by IgM capture and IgG enzyme-linked immunosorbent assay (ELISA) in groups of convalescent diagnostic sera from outbreaks in Kikwit, Democratic Republic of Congo (n = 24), Gulu, Uganda (n = 20), Bundibugyo, Uganda (n = 33), and the Philippines (n = 18), which represent outbreaks due to four different EBOV species. For groups of samples from Kikwit, Gulu, and Bundibugyo, some limited IgM cross-reactivity was noted between heterologous sera-antigen pairs, however, IgM responses were largely stronger against autologous antigen. In some instances IgG responses were higher to autologous antigen than heterologous antigen, however, in contrast to IgM responses, we observed strong cross-reactive IgG antibody responses to heterologous antigens among all sets of samples. Finally, we examined autologous IgM and IgG antibody levels, relative to time following EHF onset, and observed early peaking and declining IgM antibody levels (by 80 days) and early development and persistence of IgG antibodies among all samples, implying a consistent pattern of antibody kinetics, regardless of EBOV species. Our findings demonstrate limited cross-reactivity of IgM antibodies to EBOV, however, the stronger tendency for cross-reactive IgG antibody responses can largely circumvent limitations in the utility of heterologous antigen for diagnostic assays and may assist in the development of antibody-mediated vaccines to EBOV.
C1 [MacNeil, Adam; Reed, Zachary; Rollin, Pierre E.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA.
RP MacNeil, A (reprint author), Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA.
EM aho3@cdc.gov
FU Centers for Disease Control and Prevention
FX All funding for this research was provided by the Centers for Disease
Control and Prevention. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 45
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Z9 29
U1 1
U2 30
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD JUN
PY 2011
VL 5
IS 6
AR e1175
DI 10.1371/journal.pntd.0001175
PG 8
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 784EZ
UT WOS:000292139600019
PM 21666792
ER
PT J
AU Robertson, K
Lumlertdacha, B
Franka, R
Petersen, B
Bhengsri, S
Henchaichon, S
Peruski, LF
Baggett, HC
Maloney, SA
Rupprecht, CE
AF Robertson, Kis
Lumlertdacha, Boonlert
Franka, Richard
Petersen, Brett
Bhengsri, Saithip
Henchaichon, Sununta
Peruski, Leonard F.
Baggett, Henry C.
Maloney, Susan A.
Rupprecht, Charles E.
TI Rabies-Related Knowledge and Practices among Persons at Risk of Bat
Exposures in Thailand
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID SEROLOGIC EVIDENCE; LYSSAVIRUS; VIRUS; SURVEILLANCE; INFECTIONS;
BARTONELLA; SITUATION; CAMBODIA; DISEASE
AB Background: Rabies is a fatal encephalitis caused by lyssaviruses. Evidence of lyssavirus circulation has recently emerged in Southeast Asian bats. A cross-sectional study was conducted in Thailand to assess rabies-related knowledge and practices among persons regularly exposed to bats and bat habitats. The objectives were to identify deficiencies in rabies awareness, describe the occurrence of bat exposures, and explore factors associated with transdermal bat exposures.
Methods: A survey was administered to a convenience sample of adult guano miners, bat hunters, game wardens, and residents/personnel at Buddhist temples where mass bat roosting occurs. The questionnaire elicited information on demographics, experience with bat exposures, and rabies knowledge. Participants were also asked to describe actions they would take in response to a bat bite as well as actions for a bite from a potentially rabid animal. Bivariate analysis was used to compare responses between groups and multivariable logistic regression was used to explore factors independently associated with being bitten or scratched by a bat.
Findings: Of 106 people interviewed, 11 (10%) identified bats as a potential source of rabies. A history of a bat bite or scratch was reported by 29 (27%), and 38 (36%) stated either that they would do nothing or that they did not know what they would do in response to a bat bite. Guano miners were less likely than other groups to indicate animal bites as a mechanism of rabies transmission (68% vs. 90%, p = 0.03) and were less likely to say they would respond appropriately to a bat bite or scratch (61% vs. 27%, p = 0.003). Guano mining, bat hunting, and being in a bat cave or roost area more than 5 times a year were associated with history of a bat bite or scratch.
Conclusions: These findings indicate the need for educational outreach to raise awareness of bat rabies, promote exposure prevention, and ensure appropriate health-seeking behaviors for bat-inflicted wounds, particularly among at-risk groups in Thailand.
C1 [Robertson, Kis; Petersen, Brett] Ctr Dis Control & Prevent CDC, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA.
[Lumlertdacha, Boonlert] Thai Red Cross Soc, Queen Saovabha Mem Inst, WHO Collaborating Ctr Res Rabies, Bangkok, Thailand.
[Franka, Richard; Rupprecht, Charles E.] Ctr Dis Control & Prevent CDC, Poxvirus & Rabies Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA USA.
[Bhengsri, Saithip; Henchaichon, Sununta; Peruski, Leonard F.; Baggett, Henry C.; Maloney, Susan A.] Ctr Dis Control & Prevent CDC, Int Emerging Infect Program, Global Dis Detect & Emergency Response Div, Bangkok, Thailand.
RP Robertson, K (reprint author), Ctr Dis Control & Prevent CDC, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA 30333 USA.
EM kir6@cdc.gov
FU Centers for Disease Control and Prevention (CDC)
FX This study was funded by the Centers for Disease Control and Prevention
(CDC). CDC scientists participated in the study design, data collection
and analysis, decision to publish, and preparation of the manuscript.
NR 31
TC 4
Z9 5
U1 2
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2727
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD JUN
PY 2011
VL 5
IS 6
AR e1054
DI 10.1371/journal.pntd.0001054
PG 7
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 784EZ
UT WOS:000292139600005
PM 21738801
ER
PT J
AU He, M
Ouyang, ZM
Troxell, B
Xu, HJ
Moh, A
Piesman, J
Norgard, MV
Gomelsky, M
Yang, XF
AF He, Ming
Ouyang, Zhiming
Troxell, Bryan
Xu, Haijun
Moh, Akira
Piesman, Joseph
Norgard, Michael V.
Gomelsky, Mark
Yang, X. Frank
TI Cyclic di-GMP is Essential for the Survival of the Lyme Disease
Spirochete in Ticks
SO PLOS PATHOGENS
LA English
DT Article
ID REGULATES BIOFILM FORMATION; BORRELIA-BURGDORFERI; VIBRIO-CHOLERAE;
RESPONSE REGULATOR; YERSINIA-PESTIS; PSEUDOMONAS-AERUGINOSA;
BINDING-PROTEIN; DOMAIN PROTEIN; MAMMALIAN INFECTION; ESCHERICHIA-COLI
AB Cyclic dimeric GMP (c-di-GMP) is a bacterial second messenger that modulates many biological processes. Although its role in bacterial pathogenesis during mammalian infection has been documented, the role of c-di-GMP in a pathogen's life cycle within a vector host is less understood. The enzootic cycle of the Lyme disease pathogen Borrelia burgdorferi involves both a mammalian host and an Ixodes tick vector. The B. burgdorferi genome encodes a single copy of the diguanylate cyclase gene (rrp1), which is responsible for c-di-GMP synthesis. To determine the role of c-di-GMP in the life cycle of B. burgdorferi, an Rrp1-deficient B. burgdorferi strain was generated. The rrp1 mutant remains infectious in the mammalian host but cannot survive in the tick vector. Microarray analyses revealed that expression of a four-gene operon involved in glycerol transport and metabolism, bb0240-bb0243, was significantly downregulated by abrogation of Rrp1. In vitro, the rrp1 mutant is impaired in growth in the media containing glycerol as the carbon source (BSK-glycerol). To determine the contribution of the glycerol metabolic pathway to the rrp1 mutant phenotype, a glp mutant, in which the entire bb0240-bb0243 operon is not expressed, was generated. Similar to the rrp1 mutant, the glp mutant has a growth defect in BSK-glycerol medium. In vivo, the glp mutant is also infectious in mice but has reduced survival in ticks. Constitutive expression of the bb0240-bb0243 operon in the rrp1 mutant fully rescues the growth defect in BSK-glycerol medium and partially restores survival of the rrp1 mutant in ticks. Thus, c-di-GMP appears to govern a catabolic switch in B. burgdorferi and plays a vital role in the tick part of the spirochetal enzootic cycle. This work provides the first evidence that c-di-GMP is essential for a pathogen's survival in its vector host.
C1 [He, Ming; Troxell, Bryan; Xu, Haijun; Moh, Akira; Yang, X. Frank] Indiana Univ Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA.
[Ouyang, Zhiming; Norgard, Michael V.] Univ Texas SW Med Ctr, Dept Microbiol, Dallas, TX USA.
[Xu, Haijun] Zhejiang Univ, Inst Insect Sci, Hangzhou 310003, Zhejiang, Peoples R China.
[Piesman, Joseph] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Vector Borne Dis, Ft Collins, CO USA.
[Gomelsky, Mark] Univ Wyoming, Dept Mol Biol, Laramie, WY 82071 USA.
RP He, M (reprint author), Indiana Univ Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA.
EM xfyang@iupui.edu
RI gomelsky, mark/F-6209-2010;
OI Xu, Hai-Jun/0000-0002-7314-377X; Troxell, Bryan/0000-0002-0533-6721
FU NIH [R01 AI083640, R21 AI085242]; American Heart Association; Lilly
Endowment, Inc.; National Center for Research Resources, NIH [C06
RR015481-01]; NIH-NIAID [AI060519]
FX Funding for this work was partially provided by NIH grants R01 AI083640
(XFY), R21 AI085242 (XFY), the American Heart Association Scientist
Development Grant (XFY), and Indiana INGEN and METACyt grants of Indiana
University, funded by the Lilly Endowment, Inc. (XFY). This
investigation was partially conducted in a facility constructed with
support from research facilities improvement program grant (C06
RR015481-01) from National Center for Research Resources, NIH. B.T. is
supported by a NIH-NIAID T32 training grant AI060519. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 94
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U1 1
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1553-7366
J9 PLOS PATHOG
JI PLoS Pathog.
PD JUN
PY 2011
VL 7
IS 6
AR e1002133
DI 10.1371/journal.ppat.1002133
PG 15
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA 787MC
UT WOS:000292379600047
PM 21738477
ER
PT J
AU Gust, DA
Kretsinger, K
Pals, SL
Gaul, ZJ
Heffelfinger, JD
Begley, EB
Chen, RT
Kilmarx, PH
AF Gust, Deborah A.
Kretsinger, Katrina
Pals, Sherri L.
Gaul, Zaneta J.
Heffelfinger, James D.
Begley, Elin B.
Chen, Robert T.
Kilmarx, Peter H.
TI Male circumcision as an HIV prevention intervention in the U.S.:
Influence of health care providers and potential for risk compensation
(vol 52, pg 270, 2011)
SO PREVENTIVE MEDICINE
LA English
DT Correction
C1 [Gust, Deborah A.; Kretsinger, Katrina; Pals, Sherri L.; Gaul, Zaneta J.; Heffelfinger, James D.; Begley, Elin B.; Chen, Robert T.; Kilmarx, Peter H.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
RP Gust, DA (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
EM dgust@cdc.gov
NR 1
TC 0
Z9 0
U1 1
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
J9 PREV MED
JI Prev. Med.
PD JUN 1
PY 2011
VL 52
IS 6
BP 482
EP 482
DI 10.1016/j.ypmed.2011.04.008
PG 1
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 779DQ
UT WOS:000291758700024
ER
PT J
AU Hootman, JM
Driban, JB
Sitler, MR
Harris, KP
Cattano, NM
AF Hootman, Jennifer M.
Driban, Jeffrey B.
Sitler, Michael R.
Harris, Kyle P.
Cattano, Nicole M.
TI Reliability and validity of three quality rating instruments for
systematic reviews of observational studies
SO RESEARCH SYNTHESIS METHODS
LA English
DT Review
DE instrument psychometrics; research methods; systematic review;
meta-analysis
AB To assess the inter-rater reliability, validity, and inter-instrument agreement of the three quality rating instruments for observational studies. Inter-rater reliability, criterion validity, and inter-instrument reliability were assessed for three quality rating scales, the Downs and Black (D&B), Newcastle-Ottawa (NOS), and Scottish Intercollegiate Guidelines Network (SIGN), using a sample of 23 observational studies of musculoskeletal health outcomes. Inter-rater reliability for the D&B (Intraclass correlations [ICC] = 0.73; CI = 0.47-0.88) and NOS (ICC = 0.52; CI = 0.14-0.76) were moderate to good and was poor for the SIGN (kappa = 0.09; CI = -0.22-0.40). The NOS was not statistically valid (p = 0.35), although the SIGN was statistically valid (p<0.05) with medium to large effect sizes (f(2) = 0.29-0.47). Inter-instrument agreement estimates were kappa = 0.34, CI = 0.05-0.62 (D&B versus SIGN), kappa = 0.26, CI = 0.00-0.52 (SIGN versus NOS), and kappa = 0.43, CI = 0.09-0.78 (D&B versus NOS). Reliability and validity are quite variable across quality rating scales used in assessing observational studies in systematic reviews. Copyright (C) 2011 John Wiley & Sons, Ltd.
C1 [Hootman, Jennifer M.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Adult & Community Hlth, Atlanta, GA 30341 USA.
[Driban, Jeffrey B.; Sitler, Michael R.; Harris, Kyle P.] Temple Univ, Dept Kinesiol, Athlet Training Div, Biokinet Res Lab, Philadelphia, PA 19122 USA.
[Driban, Jeffrey B.] Tufts Med Ctr, Div Rheumatol, Boston, MA USA.
[Cattano, Nicole M.] W Chester Univ, Dept Sports Med, W Chester, PA 19380 USA.
RP Hootman, JM (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, 4770 Buford Highway NE,Mailstop K-51, Atlanta, GA 30341 USA.
EM jhootman@cdc.gov
OI Driban, Jeffrey/0000-0001-6098-4273
NR 46
TC 14
Z9 14
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1759-2879
EI 1759-2887
J9 RES SYNTH METHODS
JI Res. Synth. Methods
PD JUN
PY 2011
VL 2
IS 2
BP 110
EP 118
DI 10.1002/jrsm.41
PG 9
WC Mathematical & Computational Biology; Multidisciplinary Sciences
SC Mathematical & Computational Biology; Science & Technology - Other
Topics
GA V38ZG
UT WOS:000209380700004
PM 26061679
ER
PT J
AU Leichliter, JS
Paz-Bailey, G
Friedman, AL
Habel, MA
Vezi, A
Sello, M
Farirai, T
Lewis, DA
AF Leichliter, Jami S.
Paz-Bailey, Gabriela
Friedman, Allison L.
Habel, Melissa A.
Vezi, Alex
Sello, Martha
Farirai, Thato
Lewis, David A.
TI 'Clinics aren't meant for men': Sexual health care access and seeking
behaviours among men in Gauteng province, South Africa
SO SAHARA J-JOURNAL OF SOCIAL ASPECTS OF HIV-AIDS
LA English
DT Article
DE sexual health care access; men
ID TRANSMITTED-DISEASES; REPRODUCTIVE HEALTH; AIDS STIGMA; INFECTIONS;
SECTOR; MODEL; DETERMINANTS; COMMUNITIES; SERVICES; TOWN
AB Men may be key players in the transmission of sexually transmitted infections (STI), and it is important that STI/HIV health services reach men. The objective of this study was to explore sexual health care access and seeking behaviours in men. This study used focus groups to examine sexual health care access and seeking behaviours in men 5 years after implementation of free antiretroviral therapy (ART) in the South African public sector. Six focus groups (N = 58) were conducted with men = 18 years in an urban area of Gauteng province. Men were recruited from various locations throughout the community. Men reported several barriers and facilitators to the use of public and private clinics for sexual health services including HIV testing, and many men reported seeking care from traditional healers. Men often viewed public clinics as a place for women and reported experiences with some female nurses who were rude or judgmental of the men. Additionally, some men reported that they sought sexual health care services at public clinics; however, they were not given physical examinations by health care providers to diagnose their STI syndrome. Most men lacked knowledge about ART and avoided HIV testing because of fear of death or being abandoned by their families or friends. Study findings suggest that men still require better access to high-quality, non-judgmental sexual health care services. Future research is needed to determine the most effective method to increase men's access to sexual health care services.
C1 [Leichliter, Jami S.; Friedman, Allison L.; Habel, Melissa A.] US Ctr Dis Control & Prevent, Div STD Prevent, Behav Intervent & Res Branch, Atlanta, GA USA.
[Sello, Martha] Natl Inst Communicable Dis, STI Reference Ctr, Johannesburg, South Africa.
RP Leichliter, JS (reprint author), US Ctr Dis Control & Prevent, Div STD Prevent, Behav Intervent & Res Branch, Atlanta, GA USA.
EM jleichliter@cdc.gov
NR 30
TC 7
Z9 7
U1 0
U2 5
PU SA MEDICAL ASSOC HEALTH & MEDICAL PUBL GROUP
PI CLAREMONT
PA 21 DREYER ST, 4TH FLOOR, SANCLARE BLDG, CLAREMONT, 7700, SOUTH AFRICA
SN 1729-0376
J9 SAHARA J-J SOC ASP H
JI Sahara J-J. Soc. Asp. HIV/AIDS
PD JUN
PY 2011
VL 8
IS 2
BP 82
EP 88
DI 10.1080/17290376.2011.9724989
PG 7
WC Health Policy & Services; Public, Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA 958PQ
UT WOS:000305253100005
PM 23237685
ER
PT J
AU Kirkcaldy, RD
Mika, J
Newman, LM
Langa, J
Tian, LH
Jani, I
Ballard, R
Nelson, L
Folgosa, E
AF Kirkcaldy, Robert D.
Mika, Jennifer
Newman, Lori M.
Langa, Judite
Tian, Linhui
Jani, Ilesh
Ballard, Ron
Nelson, Lisa
Folgosa, Elena
TI BACTERIAL VAGINOSIS, ALTERATIONS IN VAGINAL FLORA AND HIV GENITAL
SHEDDING AMONG HIV-1-INFECTED WOMEN IN MOZAMBIQUE
SO SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE
LA English
DT Article
ID TRACT
AB Objectives. We investigated whether abnormal vaginal flora, including bacterial vaginosis (BV), are associated with detection of cervical HIV-1 RNA among HIV-infected women in Mozambique.
Methods. We obtained clinical data and vaginal specimens from HIV-infected women registering for their first visit at one of two HIV care clinics in Mozambique. We compared women with detectable cervical HIV viral load (40 copies/ml) with women with undetectable cervical HIV.
Results. We enrolled 106 women. Women with abnormal vaginal flora (intermediate Nugent scores, 4 - 6) were more likely to have detectable cervical HIV RNA than women with normal vaginal flora (adjusted odds ratio 7.2 (95% confidence interval 1.8 - 29.1), adjusted for CD4 count). Women with BV had a non-significantly higher likelihood of detectable cervical HIV than women with normal flora.
Conclusions. Abnormal vaginal flora were significantly associated with cervical HIV expression. Further research is needed to confirm this relationship.
C1 [Kirkcaldy, Robert D.; Mika, Jennifer; Newman, Lori M.; Langa, Judite; Tian, Linhui; Ballard, Ron; Nelson, Lisa] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Folgosa, Elena] Eduardo Mondlane Univ, Maputo, Mozambique.
RP Kirkcaldy, RD (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
NR 5
TC 0
Z9 0
U1 0
U2 0
PU SA HIV CLINICIANS SOC
PI HOUGHTON, JOHANNESBURG
PA SUITE 233, POSTNET KILLARNEY, PRIVATE BAG X2600, HOUGHTON, JOHANNESBURG,
2041, SOUTH AFRICA
SN 1608-9693
J9 S AFR J HIV MED
JI South. Afr. J. HIV Med.
PD JUN
PY 2011
IS 40
BP 22
EP 24
PG 3
WC Infectious Diseases; Virology
SC Infectious Diseases; Virology
GA 783ZE
UT WOS:000292122600004
ER
PT J
AU Bowzard, JB
Davis, WG
Jeisy-Scott, V
Ranjan, P
Gangappa, S
Fujita, T
Sambhara, S
AF Bowzard, J. Bradford
Davis, William G.
Jeisy-Scott, Victoria
Ranjan, Priya
Gangappa, Shivaprakash
Fujita, Takashi
Sambhara, Suryaprakash
TI PAMPer and tRIGer: ligand-induced activation of RIG-I
SO TRENDS IN BIOCHEMICAL SCIENCES
LA English
DT Review
ID DOUBLE-STRANDED-RNA; INDUCIBLE GENE-I; INNATE IMMUNITY; ANTIVIRAL
RESPONSES; 5'-TRIPHOSPHATE RNA; RECOGNITION; POLYMERASE; HELICASE;
RECEPTOR; VIRUS
AB Retinoic-acid-inducible gene-I (RIG-I) is an important component of the innate immune response to many RNA viruses that limits viral replication until adaptive immunity becomes available to clear the infection. Upon binding to the nucleic acid genomes and replication intermediates of these viruses, RIG-I undergoes a complex activation process that involves post-translational modifications and structural rearrangements. Once activated, RIG-I upregulates well-studied signal transduction pathways that lead to the production of type-I interferons (IFNs) and a large variety of antiviral IFN-stimulated genes. Thus, an effective antiviral response is dependent on the interaction between pathogen-derived ligands and RIG-I. Recent work has begun to clarify the required characteristics of RIG-I activators and is setting the stage for the identification of authentic ligands used during viral infection.
C1 [Fujita, Takashi] Kyoto Univ, Inst Virus Res, Mol Genet Lab, Kyoto 6068507, Japan.
[Bowzard, J. Bradford; Davis, William G.; Jeisy-Scott, Victoria; Ranjan, Priya; Gangappa, Shivaprakash; Sambhara, Suryaprakash] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA.
RP Fujita, T (reprint author), Kyoto Univ, Inst Virus Res, Mol Genet Lab, 53 Shogoin Kawara Sakyo, Kyoto 6068507, Japan.
EM tfujita@virus.kyoto-u.ac.jp; ssambhara@cdc.gov
NR 42
TC 7
Z9 7
U1 1
U2 3
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0968-0004
J9 TRENDS BIOCHEM SCI
JI Trends Biochem.Sci.
PD JUN
PY 2011
VL 36
IS 6
BP 314
EP 319
DI 10.1016/j.tibs.2011.03.003
PG 6
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 784AT
UT WOS:000292126700003
PM 21497095
ER
PT J
AU Budnitz, DS
Lovegrove, MC
Crosby, AE
AF Budnitz, Daniel S.
Lovegrove, Maribeth C.
Crosby, Alexander E.
TI Emergency Department Visits for Overdoses of Acetaminophen-Containing
Products
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID ACUTE LIVER-FAILURE; UNITED-STATES; PACK SIZES; PARACETAMOL;
SURVEILLANCE; POPULATION; CHILDREN; ADOLESCENTS; REDUCTION; KNOWLEDGE
AB Background: Limited national data on the circumstances of acetaminophen overdoses have hindered identification and implementation of prevention strategies.
Purpose: To estimate the frequency of and characterize risks for emergency department visits for acetaminophen overdoses that were not related to abuse in the U. S.
Methods: Data were collected from two components of the National Electronic Injury Surveillance System from January 1, 2006, through December 31, 2007, and analyzed from 2009 to 2010 to estimate the annual number of emergency department visits for non-abuse-related acetaminophen overdose by patient demographics, treatments, and type and amount of acetaminophen-containing product ingested. Results: There were an estimated 78,414 emergency department visits (95% CI=63655, 93172) annually for non-abuse-related overdoses of acetaminophen-containing products. Most emergency department visits for acetaminophen overdose were for self-directed violence (69.8%, 95% CI=66.4%, 73.2%), with the highest rate among patients aged 15-24 years (46.4 per 100,000 individuals per year). Unsupervised ingestions by children aged <6 years accounted for 13.4% (95% CI=11.0%, 15.9%) of visits for acetaminophen overdoses (42.5 per 100,000 individuals per year). Therapeutic misadventures accounted for 16.7% (95% CI=14.0%, 19.5%) of visits and most involved overuse for medicinal effects (56.1%, 95% CI=50.6%, 61.6%) rather than use of multiple acetaminophen-containing products or dose confusion.
Conclusions: Non-abuse-related overdoses of acetaminophen products lead to many emergency department visits each year, particularly emergency department visits for self-directed violence. Acetaminophen overdose prevention efforts will likely need to be multidimensional. (Am J Prev Med 2011; 40(6): 585-592) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine
C1 [Budnitz, Daniel S.; Lovegrove, Maribeth C.] CDC, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
[Crosby, Alexander E.] CDC, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA.
RP Budnitz, DS (reprint author), CDC, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd NE,Mailstop A-24, Atlanta, GA 30333 USA.
EM dbudnitz@cdc.gov
FU CDC
FX This investigation was funded by the CDC. We thank Kelly Weidenbach,
MPH, Victor Johnson (Northrop-Grumman contractors for CDC), Lee Annest,
PhD, and Tadesse Haileyesus, MS, of CDC, and Tom Schroeder, MS, Cathy
Irish, BS, Joel Friedman, BA, and staff of the Division of Hazard and
Injury Data Systems, U. S. Consumer Product Safety Commission for
assistance with data collection and processing. We thank Nadine Shehab,
PharmD, MPH, of CDC for assistance with programming and thoughtful
contributions to the manuscript. All individuals named consented to be
acknowledged and none have disclaimers to report.
NR 31
TC 33
Z9 33
U1 3
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD JUN
PY 2011
VL 40
IS 6
BP 585
EP 592
DI 10.1016/j.amepre.2011.02.026
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 762IS
UT WOS:000290470400003
PM 21565648
ER
PT J
AU Hvidtjorn, D
Grove, J
Schendel, D
Schieve, LA
Svaerke, C
Ernst, E
Thorsen, P
AF Hvidtjorn, D.
Grove, J.
Schendel, D.
Schieve, L. A.
Svaerke, C.
Ernst, E.
Thorsen, P.
TI Risk of autism spectrum disorders in children born after assisted
conception: a population-based follow-up study
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
LA English
DT Article
ID IN-VITRO FERTILIZATION; OBSTETRIC COMPLICATIONS; NEUROLOGICAL SEQUELAE;
PERINATAL FACTORS; INFANTILE-AUTISM; NATIONAL COHORT; CEREBRAL-PALSY;
BIRTH-WEIGHT; IVF; REGISTER
AB Objectives To assess the risk of autism spectrum disorders (ASD) in children born after assisted conception compared with children born after natural conception.
Design Population-based follow-up study.
Setting All children born alive in Denmark 1995-2003.
Participants 588 967 children born in Denmark from January 1995 to December 2003. Assisted conception was defined as in vitro fertilisation (IVF) with or without intracytoplasmic sperm injection and ovulation induction (OI) with or without subsequent insemination. Children exposed to IVF or OI were identified in the IVF Register and in the Danish Drug Prescription Register.
Main outcome measures A diagnosis of ASD in the Danish Psychiatric Central Register.
Results 33 139 (5.6%) of all children born in Denmark in 1995-2003 resulted from assisted conception, 225 of whom (0.68%) had a diagnosis of ASD. Of the 555 828 children born in this period after natural conception, 3394 (0.61%) had a diagnosis of ASD. The follow-up time was 4-13 years (median 9 years). In crude analyses, children born after assisted conception had an increased risk of a diagnosis of ASD: crude hazard rate ratio (HRR) 1.25 (95% CI 1.09 to 1.43). In analyses adjusting for maternal age, educational level, parity, smoking, birth weight and multiplicity, the risk disappeared: adjusted HRR 1.13. (95% CI 0.97 to 1.31). However, subgroup analyses that suggest possible associations in women who received follicle stimulating hormone indicate the need for further study.
Discussion This population-based follow-up study found no risk of ASD in children born after assisted conception.
C1 [Hvidtjorn, D.; Grove, J.; Svaerke, C.; Thorsen, P.] Univ Aarhus, Dept Epidemiol, Inst Publ Hlth, DK-8000 Aarhus C, Denmark.
[Schendel, D.; Schieve, L. A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Ernst, E.] Aarhus Univ Hosp, Dept Obstet & Gynaecol, Fertil Sect, DK-8000 Aarhus, Denmark.
RP Hvidtjorn, D (reprint author), Univ Aarhus, Dept Epidemiol, Inst Publ Hlth, Paludan Mullers Vej 17, DK-8000 Aarhus C, Denmark.
EM dh@soci.au.dk
OI Grove, Jakob/0000-0003-2284-5744
FU Danish Agency for Science, Technology and Innovation, University of
Aarhus; Elsass Foundation; Sofiefonden; Health Insurance Foundation;
Augustinus Foundation; Julie von Mullens Foundation; Direktor Jacob
Madsen and Hustru Olga Madsens Fond; Aase and Ejnar Danielsen Foundation
FX The study was funded as a co-financed PhD project by The Danish Agency
for Science, Technology and Innovation, University of Aarhus and The
Elsass Foundation. Further funding was supplied by Sofiefonden, The
Health Insurance Foundation, The Augustinus Foundation, Julie von
Mullens Foundation, Direktor Jacob Madsen and Hustru Olga Madsens Fond
and Aase and Ejnar Danielsen Foundation.
NR 40
TC 41
Z9 44
U1 0
U2 18
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0143-005X
J9 J EPIDEMIOL COMMUN H
JI J. Epidemiol. Community Health
PD JUN
PY 2011
VL 65
IS 6
BP 497
EP 502
DI 10.1136/jech.2009.093823
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 758ZW
UT WOS:000290209400006
PM 20584728
ER
PT J
AU Rolnick, SJ
Rahm, AK
Jackson, JM
Nekhlyudov, L
Goddard, KAB
Field, T
McCarty, C
Nakasato, C
Roblin, D
Anderson, CP
Valdez, R
AF Rolnick, Sharon J.
Rahm, Alanna K.
Jackson, Jody M.
Nekhlyudov, Larissa
Goddard, Katrina A. B.
Field, Terry
McCarty, Catherine
Nakasato, Cynthia
Roblin, Douglas
Anderson, Christopher P.
Valdez, Rodolfo
TI Barriers in Identification and Referral to Genetic Counseling for
Familial Cancer Risk: The Perspective of Genetic Service Providers
SO JOURNAL OF GENETIC COUNSELING
LA English
DT Article
DE Genetic counseling; Genetic predisposition to disease; Genetic
screening; Neoplasms; Referral and consultation
ID PRIMARY-CARE PHYSICIANS; HEREDITARY BREAST-CANCER; COLORECTAL-CANCER;
DISEASE PREVENTION; GENOMIC MEDICINE; AMERICAN-SOCIETY; IMPROVING
HEALTH; NATIONAL SAMPLE; HISTORY; BREAST/OVARIAN
AB The purpose of this study was to obtain genetic counselors' perspectives about the identification of appropriate patients and barriers to referral of high-risk patients for cancer genetic counseling services. Genetic service providers from eight integrated health systems were surveyed. Data analysis included descriptive statistics. Twenty-eight of 40 potential participants responded (70%). Referrals for familial cancer risk assessment overwhelmingly came from providers (89%); only 10% were self-referrals. Use of guidelines to assist providers with referral was reported by 46% of the respondents. Genetic service providers perceived patient barriers to seeking genetic counseling after referral included: risk evaluation viewed as a non-priority (72%), concerns about impact on insurability (52%), distance to appointments (48%), lack of insurance (44%), lack of patient/provider knowledge about the value of genetic counseling (36%), discouragement by family members (28%), and fear (20%). The best approaches suggested by respondents to increase appropriate referrals were attending meetings and giving presentations to oncologists, surgeons, primary care and gynecologists. The genetic service providers reported several barriers to the referral and use of genetic counseling. This finding is consistent with current literature from the providers' perspective. Our survey adds the genetic service providers' perspective and identifies areas of opportunity for further research and intervention as few of the perceived barriers are being addressed through current educational efforts.
C1 [Rolnick, Sharon J.; Jackson, Jody M.; Anderson, Christopher P.] HealthPartners Res Fdn, Minneapolis, MN 55440 USA.
[Rahm, Alanna K.] Kaiser Permanente, Inst Hlth Res, Denver, CO USA.
[Nekhlyudov, Larissa] Harvard Univ, Sch Med, Dept Populat Med, Boston, MA USA.
[Nekhlyudov, Larissa] Harvard Vanguard Med Associates, Dept Med, Boston, MA USA.
[Goddard, Katrina A. B.] Kaiser Permanente NW, Ctr Hlth Res, Portland, OR USA.
[Field, Terry] Meyers Primary Care Inst, Worcester, MA USA.
[McCarty, Catherine] Marshfield Clin Res Fdn, Marshfield, WI USA.
[Nakasato, Cynthia] Kaiser Permanente Ctr Hlth Res, Honolulu, HI USA.
[Roblin, Douglas] Ctr Hlth Res SE, Atlanta, GA USA.
[Valdez, Rodolfo] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA USA.
RP Rolnick, SJ (reprint author), HealthPartners Res Fdn, POB 1524,MS 21111R, Minneapolis, MN 55440 USA.
EM Cheri.J.Rolnick@healthpartners.com
FU National Cancer Institute [5U19 CA079689]
FX This study was funded by the National Cancer Institute, contract 5U19
CA079689, "Increasing the Effectiveness of Cancer Control Interventions"
(Edward H. Wagner, MD, MPH, Principal Investigator), which provides
financial support for the HMO Cancer Research Network (CRN). We want to
acknowledge the members of the CRN Family History Scientific Interest
Group who contributed to the conceptual design of this project and/or
provided input on this manuscript, particularly Andrea F. Patenaude, PhD
from the Dana Farber Cancer Institute (Boston, MA). We also want to
thank the genetics professionals who participated in the survey. The
corresponding author may be contacted to request a copy of the full
survey.
NR 53
TC 9
Z9 9
U1 1
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-7700
J9 J GENET COUNS
JI J. Genet. Couns.
PD JUN
PY 2011
VL 20
IS 3
BP 314
EP 322
DI 10.1007/s10897-011-9351-3
PG 9
WC Genetics & Heredity
SC Genetics & Heredity
GA 762EC
UT WOS:000290454500009
PM 21503824
ER
PT J
AU Oster, ME
Riehle-Colarusso, T
Alverson, CJ
Correa, A
AF Oster, Matthew E.
Riehle-Colarusso, Tiffany
Alverson, Clinton J.
Correa, Adolfo
TI Associations Between Maternal Fever and Influenza and Congenital Heart
Defects
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID VENTRICULAR SEPTAL-DEFECTS; NEURAL-TUBE DEFECTS; BIRTH-DEFECTS;
CARDIOVASCULAR MALFORMATIONS; RISK-FACTORS; MULTIVITAMIN USE;
CHICK-EMBRYOS; HYPERTHERMIA; PREGNANCY; ABNORMALITIES
AB Objective To examine associations between maternal reports of prenatal fever or influenza and congenital heart defects (CHDs), and to evaluate whether those associations varied with antipyretic use.
Study design We analyzed case infants with CHD (n = 2361) and control infants without CHD (n = 3435) from the Baltimore-Washington Infant Study (1981-1989). Participating mothers were asked whether they experienced a "fever of 101 degrees F or higher,'' had "influenza (flu),'' or used an antipyretic agent (ie, acetaminophen, salicylate, or nonsteroidal anti-inflammatory drug) during the period extending from 3 months before pregnancy through the end of the third month of pregnancy. We used logistic regression to compute ORs and 95% CIs while controlling for potential confounders.
Results There were significant associations between fever and influenza and specific CHDs, namely right-sided obstructive defects (fever: OR, 2.04; 95% CI, 1.27 to 3.27; influenza: OR, 1.75; 95% CI, 1.16 to 2.62) and atrioventricular septal defects in infants with Down syndrome (fever: OR, 1.92; 95% CI, 1.10 to 3.38; influenza: OR, 1.66; 95% CI, 1.04 to 2.63). Maternal antipyretic use in the setting of fever or influenza tended to decrease these associations.
Conclusions Prenatal maternal fever or influenza may be associated with right-sided obstructive lesions in all infants and with atrioventricular septal defects in infants with Down syndrome. The use of antipyretics might attenuate such associations. (J Pediatr 2011;158:990-5).
C1 [Oster, Matthew E.] Emory Univ, Div Pediat Cardiol, Childrens Healthcare Atlanta, Atlanta, GA 30322 USA.
[Oster, Matthew E.; Riehle-Colarusso, Tiffany; Alverson, Clinton J.; Correa, Adolfo] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
RP Oster, ME (reprint author), Emory Univ, Div Pediat Cardiol, Childrens Healthcare Atlanta, 1405 Clifton Rd NE, Atlanta, GA 30322 USA.
EM matthew.oster@choa.org
NR 36
TC 24
Z9 25
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
J9 J PEDIATR-US
JI J. Pediatr.
PD JUN
PY 2011
VL 158
IS 6
BP 990
EP 995
DI 10.1016/j.jpeds.2010.11.058
PG 6
WC Pediatrics
SC Pediatrics
GA 763LQ
UT WOS:000290558600026
PM 21256509
ER
PT J
AU Daniels, RD
Schubauer-Berigan, MK
AF Daniels, R. D.
Schubauer-Berigan, M. K.
TI A meta-analysis of leukaemia risk from protracted exposure to low-dose
gamma radiation
SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Review
ID CHRONIC LYMPHOCYTIC-LEUKEMIA; PORTSMOUTH-NAVAL-SHIPYARD; POWER INDUSTRY
WORKERS; MAYAK NUCLEAR-COMPLEX; IONIZING-RADIATION; CANCER INCIDENCE;
LUNG-CANCER; HEMATOLOGICAL MALIGNANCIES; CIGARETTE-SMOKING; MORTALITY
AB Context More than 400 000 workers annually receive a measurable radiation dose and may be at increased risk of radiation-induced leukaemia. It is unclear whether leukaemia risk is elevated with protracted, low-dose exposure.
Objective We conducted a meta-analysis examining the relationship between protracted low-dose ionising radiation exposure and leukaemia.
Data sources Reviews by the National Academies and United Nations provided a summary of informative studies published before 2005. PubMed and Embase databases were searched for additional occupational and environmental studies published between 2005 and 2009.
Study selection We selected 23 studies that: (1) examined the association between protracted exposures to ionising radiation and leukaemia excluding chronic lymphocytic subtype; (2) were a cohort or nested case-control design without major bias; (3) reported quantitative estimates of exposure; and (4) conducted exposure-response analyses using relative or excess RR per unit exposure.
Methods Studies were further screened to reduce information overlap. Random effects models were developed to summarise between-study variance and obtain an aggregate estimate of the excess RR at 100 mGy. Publication bias was assessed by trim and fill and Rosenthal's file drawer methods.
Results We found an ERR at 100 mGy of 0.19 (95% CI 0.07 to 0.32) by modelling results from 10 studies and adjusting for publication bias. Between-study variance was not evident (p = 0.99).
Conclusions Protracted exposure to low-dose gamma radiation is significantly associated with leukaemia. Our estimate agreed well with the leukaemia risk observed among exposed adults in the Life Span Study (LSS) of atomic bomb survivors, providing increased confidence in the current understanding of leukaemia risk from ionising radiation. However, unlike the estimates obtained from the LSS, our model provides a precise, quantitative summary of the direct estimates of excess risk from studies of protracted radiation exposures.
C1 [Daniels, R. D.; Schubauer-Berigan, M. K.] NIOSH, DSHEFS, US Ctr Dis Control & Prevent CDC, Cincinnati, OH 45226 USA.
RP Daniels, RD (reprint author), NIOSH, DSHEFS, US Ctr Dis Control & Prevent CDC, 4676 Columbia Pkwy,R-14, Cincinnati, OH 45226 USA.
EM RTD2@CDC.gov
RI Schubauer-Berigan, Mary/B-3149-2009
OI Schubauer-Berigan, Mary/0000-0002-5175-924X
NR 66
TC 21
Z9 21
U1 2
U2 9
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1351-0711
EI 1470-7926
J9 OCCUP ENVIRON MED
JI Occup. Environ. Med.
PD JUN
PY 2011
VL 68
IS 6
BP 457
EP 464
DI 10.1136/oem.2009.054684
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 762XX
UT WOS:000290516600014
PM 20935290
ER
PT J
AU Gust, DA
Kretsinger, K
Gaul, Z
Pals, S
Heffelfinger, JD
Begley, E
Chen, RT
Kilmarx, PH
AF Gust, Deborah A.
Kretsinger, Katrina
Gaul, Zaneta
Pals, Sherri
Heffelfinger, James D.
Begley, Elin
Chen, Robert T.
Kilmarx, Peter H.
TI Acceptability of Newborn Circumcision to Prevent HIV Infection in the
United States
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
ID URINARY-TRACT-INFECTION; HUMAN-PAPILLOMAVIRUS; NEONATAL-CIRCUMCISION;
CERVICAL-CANCER; HEALTH; MEN; PARENTS; POLICY; YOUNG; INTERVENTION
AB Background/Purpose: To understand whether information from the African clinical trials about the partially protective effect of male circumcision against human immunodeficiency virus (HIV) infection could influence adults to circumcise a newborn son.
Methods: Using the 2008 ConsumerStyles panel survey data, multiple regression analysis was performed to identify correlates of (1) inclination toward circumcising a newborn son and (2) being influenced to have a newborn son circumcised if it would reduce the chance of becoming HIV infected later in life.
Results: Response rate was 50.6% (10,108/19,996). Approximately 12% reported not being inclined to circumcise a newborn son. Higher odds of not being inclined to circumcise a newborn son were associated with Hispanic and "other" race/ethnicity, being an uncircumcised man and a man not reporting circumcision status, postgraduate education, region, and negative health-related attitudes. Lower odds were associated with black race and less number of household members. Fifty-three percent of respondents reported that information about the protective effect of circumcision would make them more likely to have a newborn son circumcised. Higher odds of being influenced to have a newborn son circumcised were associated with being >= 45 years of age, black race, living in a household with fewer than 5 members, having high school or some college education, region, and positive health-related attitudes; lower odds were associated with being an uncircumcised man and lower income.
Conclusions: Our findings suggest that providing educational information about the HIV prevention and benefit of circumcision may increase the inclination to circumcise a newborn son for some people.
C1 [Gust, Deborah A.; Kretsinger, Katrina; Gaul, Zaneta; Pals, Sherri; Heffelfinger, James D.; Begley, Elin; Chen, Robert T.; Kilmarx, Peter H.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
RP Gust, DA (reprint author), CDC, Div HIV AIDS Prevent, Epidemiol Branch, HIV Vaccine & Special Studies Team, 1600 Clifton Rd,Mail Stop E-45, Atlanta, GA 30333 USA.
EM dgust@cdc.gov
OI Kilmarx, Peter/0000-0001-6464-3345
NR 39
TC 6
Z9 6
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-5717
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD JUN
PY 2011
VL 38
IS 6
BP 536
EP 542
DI 10.1097/OLQ.0b013e318207f5b0
PG 7
WC Infectious Diseases
SC Infectious Diseases
GA 763MH
UT WOS:000290561200014
PM 21217414
ER
PT J
AU Tieu, HV
Xu, GZ
Bonner, S
Spikes, P
Egan, JE
Goodman, K
Stewart, K
Koblin, BA
AF Hong-Van Tieu
Xu, Guozhen
Bonner, Sebastian
Spikes, Pilgrim
Egan, James E.
Goodman, Krista
Stewart, Kiwan
Koblin, Beryl A.
TI Sexual Partner Characteristics, Serodiscordant/Serostatus Unknown
Unprotected Anal Intercourse and Disclosure Among Human Immunodeficiency
Virus-Infected and Uninfected Black Men Who Have Sex With Men in New
York City
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
ID HIV-INFECTION; UNITED-STATES; PREVENTION INTERVENTION; RISK BEHAVIORS;
BISEXUAL MEN; WHITE MEN; PREVALENCE; SURVEILLANCE; TRANSMISSION;
DISPARITIES
AB Objectives: Black men who have sex with men (MSM) are disproportionately infected with human immunodeficiency virus (HIV) in the United States. This study describes sexual partner characteristics and disclosure of HIV serostatus and evaluates factors associated with sexual risk behaviors during last sex among black MSM.
Design and Methods: Between 2008 and 2009, 328 black MSM who reported recent unprotected anal intercourse were enrolled in an HIV behavioral intervention study in New York City. Factors associated with serodiscordant/serostatus unknown UAI (defined as having UAI with a partner of different or unknown HIV serostatus) with a male partner during last sex were assessed using logistic regression.
Results: A total of 205 HIV-infected and 123 uninfected men were enrolled in this study. Almost all men (91.6%) reported having a black male partner during last sex. About half (47.3%) of men used alcohol and 38.7% used other substances before or during last sex. About two-thirds (68.8%) of participants disclosed their HIV status to their last sex partner, while 57.2% of partners disclosed. In multivariate analysis, meeting a partner on the internet or chat line was associated with serodiscordant/serostatus unknown UAI during last sex among HIV-infected men. The only factor associated with serodiscordant/serostatus unknown UAI during last sex among HIV-uninfected men was the partner being a non-main partner.
Conclusions: A significant proportion of black MSM in this study did not disclose their HIV status. Our data highlight the need for more data on dyadic variables and sexual risk behaviors among black MSM, as well as interventions to encourage communication between partners.
C1 [Hong-Van Tieu; Xu, Guozhen; Goodman, Krista; Stewart, Kiwan; Koblin, Beryl A.] New York Blood Ctr, Lab Infect Dis Prevent, Lindsley F Kimball Res Inst, New York, NY 10065 USA.
[Hong-Van Tieu] Columbia Univ Coll Phys & Surg, Dept Med, Div Infect Dis, New York, NY 10032 USA.
[Bonner, Sebastian; Egan, James E.] New York Acad Med, New York, NY USA.
[Spikes, Pilgrim] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Tieu, HV (reprint author), New York Blood Ctr, Lab Infect Dis Prevent, Lindsley F Kimball Res Inst, 310 E 67th St 3-110, New York, NY 10065 USA.
EM htieu@nybloodcenter.org
FU New York Blood Center [3UR6PS000437-03W1]; Centers for Disease Control
and Prevention [3UR6PS000437-03W1]
FX Supported by a cooperative agreement between the New York Blood Center
and the Centers for Disease Control and Prevention (3UR6PS000437-03W1).
NR 30
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U1 2
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-5717
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD JUN
PY 2011
VL 38
IS 6
BP 548
EP 554
DI 10.1097/OLQ.0b013e318203e2d7
PG 7
WC Infectious Diseases
SC Infectious Diseases
GA 763MH
UT WOS:000290561200016
PM 21217419
ER
PT J
AU Shamliyan, TA
Kane, RL
Ansari, MT
Raman, G
Berkman, ND
Grant, M
Janes, G
Maglione, M
Moher, D
Nasser, M
Robinson, KA
Segal, JB
Tsouros, S
AF Shamliyan, Tatyana A.
Kane, Robert L.
Ansari, Mohammed T.
Raman, Gowri
Berkman, Nancy D.
Grant, Mark
Janes, Gail
Maglione, Margaret
Moher, David
Nasser, Mona
Robinson, Karen A.
Segal, Jodi B.
Tsouros, Sophia
TI Development quality criteria to evaluate nontherapeutic studies of
incidence, prevalence, or risk factors of chronic diseases: pilot study
of new checklists
SO JOURNAL OF CLINICAL EPIDEMIOLOGY
LA English
DT Article
DE Risk factors; Morbidity; Reproducibility of results; Validation studies;
Bias (epidemiology); Quality control; Review literature as topic
ID COMMUNITY-PREVENTIVE-SERVICES; CLINICAL-PRACTICE GUIDELINES;
CORONARY-HEART-DISEASE; SYSTEMATIC REVIEWS; CRITICAL-APPRAISAL;
MYOCARDIAL-INFARCTION; URINARY-INCONTINENCE; MEDICAL LITERATURE;
PROGNOSTIC-FACTORS; META-ANALYSIS
AB Objective: To develop two checklists for the quality of observational studies of incidence or risk factors of diseases.
Study Design and Setting: Initial development of the checklists was based on a systematic literature review. The checklists were refined after pilot trials of validity and reliability were conducted by seven experts, who tested the checklists on 10 articles.
Results: The checklist for studies of incidence or prevalence of chronic disease had six criteria for external validity and five for internal validity. The checklist for risk factor studies had six criteria for external validity, 13 criteria for internal validity, and two aspects of causality. A Microsoft Access database produced automated standardized reports about external and internal validities. Pilot testing demonstrated face and content validities and discrimination of reporting vs. methodological qualities. Interrater agreement was poor. The experts suggested future reliability testing of the checklists in systematic reviews with preplanned protocols, a priori consensus about research-specific quality criteria, and training of the reviewers.
Conclusion: We propose transparent and standardized quality assessment criteria of observational studies using the developed checklists. Future testing of the checklists in systematic reviews is necessary to develop reliable tools that can be used with confidence. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Shamliyan, Tatyana A.; Kane, Robert L.] Univ Minnesota, Sch Publ Hlth, Div Hlth Policy & Management, Minneapolis, MN 55455 USA.
[Ansari, Mohammed T.; Moher, David; Tsouros, Sophia] Ottawa Hlth Res Inst, Clin Epidemiol Program, Ottawa Methods Ctr, Ottawa, ON, Canada.
[Raman, Gowri] Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA USA.
[Berkman, Nancy D.] RTI Int Res, Res Triangle Pk, NC USA.
[Grant, Mark] Blue Cross & Blue Shield Assoc, Chicago, IL USA.
[Janes, Gail] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Maglione, Margaret] RAND Corp, So Calif EPC, Santa Monica, CA USA.
[Nasser, Mona] German Inst Qual & Efficiency Hlth Care, Cologne, Germany.
[Robinson, Karen A.; Segal, Jodi B.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
RP Shamliyan, TA (reprint author), Univ Minnesota, Sch Publ Hlth, Div Hlth Policy & Management, 420 Delaware St SE,MMC 197, Minneapolis, MN 55455 USA.
EM sham1005@umn.edu
RI Nasser, Mona/J-3601-2013; Segal, Jodi/A-2863-2009;
OI Segal, Jodi/0000-0003-3978-9662; Moher , David /0000-0003-2434-4206
FU Agency for Healthcare Research and Quality, U.S. Department of Health
and Human Services [290-02-0009]
FX This project was funded under Contract No. 290-02-0009, from the Agency
for Healthcare Research and Quality, U.S. Department of Health and Human
Services. The authors are responsible for its content. Statements in the
article should not be construed as endorsement by the Agency for
Healthcare Research and Quality or the U.S. Department of Health and
Human Services.
NR 134
TC 37
Z9 39
U1 5
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0895-4356
EI 1878-5921
J9 J CLIN EPIDEMIOL
JI J. Clin. Epidemiol.
PD JUN
PY 2011
VL 64
IS 6
BP 637
EP 657
DI 10.1016/j.jclinepi.2010.08.006
PG 21
WC Health Care Sciences & Services; Public, Environmental & Occupational
Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA 757GY
UT WOS:000290074700009
PM 21071174
ER
PT J
AU Aoki, K
Benko, M
Davison, AJ
Echavarria, M
Erdman, DD
Harrach, B
Kajon, AE
Schnurr, D
Wadell, G
AF Aoki, Koki
Benkoe, Maria
Davison, Andrew J.
Echavarria, Marcela
Erdman, Dean D.
Harrach, Balazs
Kajon, Adriana E.
Schnurr, David
Wadell, Goran
CA Adenovirus Res Community
TI Toward an Integrated Human Adenovirus Designation System That Utilizes
Molecular and Serological Data and Serves both Clinical and Fundamental
Virology
SO JOURNAL OF VIROLOGY
LA English
DT Letter
C1 [Kajon, Adriana E.] Lovelace Resp Res Inst, Albuquerque, NM 87108 USA.
[Aoki, Koki] Hokkaido Univ, Dept Ophthalmol, Grad Sch Med, Kita Ku, Sapporo, Hokkaido 0608638, Japan.
[Benkoe, Maria; Harrach, Balazs] Hungarian Acad Sci, Vet Med Res Inst, H-1581 Budapest, Hungary.
[Davison, Andrew J.] Univ Glasgow, MRC, Ctr Virus Res, Glasgow G11 5JR, Lanark, Scotland.
[Echavarria, Marcela] CEMIC Univ Hosp, Clin Virol Unit, Buenos Aires, DF, Argentina.
[Erdman, Dean D.] Ctr Dis Control & Prevent, Atlanta, GA 30303 USA.
[Schnurr, David; Wadell, Goran] Umea Univ, S-90185 Umea, Sweden.
RP Kajon, AE (reprint author), Lovelace Resp Res Inst, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108 USA.
EM akajon@lrri.org
RI Benko, Maria/A-4135-2008; Harrach, Balazs/A-3680-2008;
OI Harrach, Balazs/0000-0002-1410-6469; Durigon, Edison/0000-0003-4898-6553
FU Medical Research Council [G0801822, MC_U130184136, MC_UU_12014/3]
NR 0
TC 15
Z9 16
U1 0
U2 5
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD JUN
PY 2011
VL 85
IS 11
BP 5703
EP 5704
DI 10.1128/JVI.00491-11
PG 2
WC Virology
SC Virology
GA 760CE
UT WOS:000290298700050
PM 21450837
ER
PT J
AU Wei, LX
Li, SY
Yang, JH
Ye, YM
Zou, J
Wang, LY
Long, R
Zurkiya, O
Zhao, TJ
Johnson, J
Qiao, JJ
Zhou, WD
Castiblanco, A
Maor, N
Chen, YY
Mao, H
Hu, XP
Yang, JJ
Liu, ZR
AF Wei, Lixia
Li, Shunyi
Yang, Jianhua
Ye, Yiming
Zou, Jin
Wang, Liya
Long, Robert
Zurkiya, Omar
Zhao, Tiejun
Johnson, Julian
Qiao, Jingjuan
Zhou, Wangda
Castiblanco, Adriana
Maor, Natalie
Chen, Yanyi
Mao, Hui
Hu, Xiaoping
Yang, Jenny J.
Liu, Zhi-Ren
TI Protein-Based MRI Contrast Agents for Molecular Imaging of Prostate
Cancer
SO MOLECULAR IMAGING AND BIOLOGY
LA English
DT Article
DE MRI; Contrast agents; Prostate cancer; Molecular imaging; Relaxivity
ID GASTRIN-RELEASING-PEPTIDE; METAL-BINDING; RECEPTOR-BINDING;
MESSENGER-RNA; DESIGN; TUMORS
AB The purpose of this study was to demonstrate a novel protein-based magnetic resonance imaging (MRI) contrast agent that has the capability of targeting prostate cancer and which provides high-sensitivity MR imaging in tumor cells and mouse models.
A fragment of gastrin-releasing peptide (GRP) was fused into a protein-based MRI contrast agent (ProCA1) at different regions. MR imaging was obtained in both tumor cells (PC3 and H441) and a tumor mouse model administrated with ProCA1.GRP.
PC3 and DU145 cells treated with ProCA1.GRPs exhibited enhanced signal in MRI. Intratumoral injection of ProCA1.GRP in a PC3 tumor model displayed enhanced MRI signal. The contrast agent was retained in the PC3 tumor up to 48 h post-injection.
Protein-based MRI contrast agent with tumor targeting modality can specifically target GRPR-positive prostate cancer. Intratumoral injection of the ProCA1 agent in the prostate cancer mouse model verified the targeting capability of ProCA1.GRP and showed a prolonged retention time in tumors.
C1 [Wei, Lixia; Li, Shunyi; Yang, Jianhua; Zou, Jin; Johnson, Julian; Qiao, Jingjuan; Zhou, Wangda; Castiblanco, Adriana; Maor, Natalie; Chen, Yanyi; Yang, Jenny J.; Liu, Zhi-Ren] Georgia State Univ, Dept Biol & Chem, Atlanta, GA 30302 USA.
[Wang, Liya; Long, Robert; Mao, Hui] Emory Univ, Dept Radiol, Atlanta, GA 30322 USA.
[Zurkiya, Omar; Zhao, Tiejun; Hu, Xiaoping] Emory Univ, Dept Biomed Engn, Atlanta, GA 30322 USA.
[Ye, Yiming] Ctr Dis Control & Prevent, Biotechnol Core Facil Branch, Atlanta, GA 30333 USA.
RP Yang, JJ (reprint author), Georgia State Univ, Dept Biol & Chem, Atlanta, GA 30302 USA.
EM chejjy@langate.gsu.edu; biozrl@langate.gsu.edu
RI Chen, Yanyi/H-7096-2013
OI Chen, Yanyi/0000-0002-7755-0882
FU NIH [CA118113, GM62999, EB007268]
FX We thank Dan Adams, Birgit Neuhaus, Dr. Christie Cater, Jie Jiang, Dr.
Leland Chung for their assistance. This work is supported in part by
research grants from NIH CA118113 to Zhi-Ren Liu and NIH GM62999 and
EB007268 to Jenny J Yang.
NR 33
TC 9
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U1 1
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1536-1632
J9 MOL IMAGING BIOL
JI Mol. Imaging. Biol.
PD JUN
PY 2011
VL 13
IS 3
BP 416
EP 423
DI 10.1007/s11307-010-0342-9
PG 8
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 759VT
UT WOS:000290277300003
PM 20574851
ER
PT J
AU Cherng, JM
Tsai, KD
Perng, DS
Wang, JS
Wei, CC
Lin, JC
AF Cherng, Jaw-Ming
Tsai, Kuen-Daw
Perng, Daw-Shyong
Wang, Jeng-Shing
Wei, Cheng-Chung
Lin, Jung-Chung
TI Diallyl sulfide protects against ultraviolet B-induced skin cancers in
SKH-1 hairless mouse: analysis of early molecular events in
carcinogenesis
SO PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
LA English
DT Article
DE chemoprevention; diallyl sulfide; skin tumors; ultraviolet
ID NF-KAPPA-B; NITRIC-OXIDE; MICE; LIGHT; INHIBITION; ACTIVATION; TUMORS;
CELLS; DNA; PROSTAGLANDIN-E2
AB Background
Diallyl sulfide (DAS) has been shown to have a preventive effect against various cancers.
Aims and objectives
We evaluated the protective effects of DAS in regression of ultraviolet B (UVB)-induced skin tumor formation in SKH-1 hairless mice and its underlying early molecular biomarkers.
Methods
We examined the efficacy of DAS in UVB light-induced skin lesion in SKH-1 hairless mice and the associated molecular events.
Results
Mice irradiated with UVB at 180 mJ/cm2 twice per week elicited 100% tumor incidence at 20 weeks. The topical application of DAS before UVB irradiation caused a delay in tumor appearance, multiplicity, and size. The topical application of DAS before and immediately after a single UVB irradiation (180 mJ/cm2) resulted in a significant decrease in UVB-induced thymine dimer-positive cells, expression of proliferative cell nuclear antigen (PCNA), terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling, and apoptotic sunburn cells, together with an increase in p53 and p21/Cip1-positive cell population in the epidermis. Simultaneously, DAS also significantly inhibited nuclear factor-kappa B (NF-kappa B), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and nitric oxide (NO) levels.
Conclusions
The protective effect of DAS against photocarcinogenesis is accompanied by the down-regulation of cell-proliferative controls, involving thymine dimer, PCNA, apoptosis, transcription factors NF-kappa B, and of inflammatory responses involving COX-2, PGE2, and NO, and up-regulation of p53, p21/Cip1 to prevent DNA damage and facilitate DNA repair.
C1 [Lin, Jung-Chung] Ctr Dis Control & Prevent, Cellular Virol Unit, Div Viral Hepatitis, Atlanta, GA 30333 USA.
[Cherng, Jaw-Ming; Wei, Cheng-Chung] Chung Shan Med Univ, Dept Internal Med, Chung Shan Med Univ Hosp, Taichung, Taiwan.
[Tsai, Kuen-Daw] China Med Univ, Dept Internal Med, Yunlin, Taiwan.
[Tsai, Kuen-Daw] Beigang Hosp, Yunlin, Taiwan.
[Tsai, Kuen-Daw] Natl Chung Cheng Univ, Inst Mol Biol, Chiayi, Taiwan.
[Perng, Daw-Shyong] I Shou Univ, Dept Internal Med, E Da Hosp, Kaohsiung, Taiwan.
[Wang, Jeng-Shing] Antai Tian Sheng Mem Hosp, Dept Internal Med, Pingtung, Taiwan.
[Wang, Jeng-Shing] Taipei Med Univ, Dept Internal Med, Taipei, Taiwan.
RP Lin, JC (reprint author), Ctr Dis Control & Prevent, Cellular Virol Unit, Div Viral Hepatitis, Atlanta, GA 30333 USA.
EM linderson1939@gmail.com
FU National Science Council (NSC) of Taiwan [97-2320-B-040-033-MY3]; China
Medical University Beigang Hospital, Taiwan
FX This work was supported in part by grants from the National Science
Council (NSC) of Taiwan (97-2320-B-040-033-MY3), China Medical
University Beigang Hospital, Taiwan.
NR 34
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Z9 8
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0905-4383
J9 PHOTODERMATOL PHOTO
JI Photodermatol. Photoimmunol. Photomed.
PD JUN
PY 2011
VL 27
IS 3
BP 138
EP 146
DI 10.1111/j.1600-0781.2011.00582.x
PG 9
WC Dermatology
SC Dermatology
GA 758NK
UT WOS:000290171300003
PM 21535167
ER
PT J
AU Cohen, C
Holmberg, SD
McMahon, BJ
Block, JM
Brosgart, CL
Gish, RG
London, WT
Block, TM
AF Cohen, C.
Holmberg, S. D.
McMahon, B. J.
Block, J. M.
Brosgart, C. L.
Gish, R. G.
London, W. T.
Block, T. M.
TI Is chronic hepatitis B being undertreated in the United States?
SO JOURNAL OF VIRAL HEPATITIS
LA English
DT Review
DE alanine aminotransferase; Asian and Pacific Islander; barriers to health
care; chronic HBV infection; HBV treatment; hepatitis B DNA; hepatitis B
virus; hepatocellular carcinoma; intravenous drug user
ID COST-EFFECTIVENESS ANALYSIS; PRIMARY-CARE PHYSICIANS; NEW-YORK-CITY;
HEPATOCELLULAR-CARCINOMA; ECONOMIC-EVALUATION; VIRUS INFECTION; HBV
INFECTION; LIVER-CANCER; KNOWLEDGE; CHINESE
AB Chronic infection with the hepatitis B virus (HBV) is a major risk factor for development of end-stage liver disease, including cirrhosis, liver failure and primary liver cancer. There are now seven antiviral agents approved by the United States Food and Drug Administration (FDA) for the management of chronic HBV infection. Despite the fact that there are between 1.4 and 2 million chronic HBV infections in the United States, fewer than 50 000 people per year receive prescriptions for HBV antiviral medications. This report discusses possible explanations for the disparity between the number of people who are chronically infected and the number of people who receive treatment. Explanations for this incongruence include the potentially large number of infected persons who are unscreened and thus remain undiagnosed, and lack of access, including insurance, education and referral to appropriate medical care, particularly for disproportionately infected populations.
C1 [Cohen, C.; Block, J. M.; London, W. T.; Block, T. M.] Hepatitis B Fdn, Doylestown, PA 18902 USA.
[Holmberg, S. D.] Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, Div Viral Hepatitis, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
[McMahon, B. J.] Alaska Native Med Ctr, Anchorage, AK USA.
[Brosgart, C. L.] Childrens Hosp & Res Ctr, Oakland, CA USA.
[Gish, R. G.] Calif Pacific Med Ctr, Liver Transplant Program, San Francisco, CA USA.
[London, W. T.] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA.
RP Cohen, C (reprint author), Hepatitis B Fdn, 3805 Old Easton Rd, Doylestown, PA 18902 USA.
EM chari@hepb.org
FU California Pacific Medical Center
FX Chari Cohen has served as an advisory board member for Gilead Sciences,
Inc. and Bristol-Myers Squibb. Chari Cohen owns stocks and shares in
Gilead Sciences, Inc. and Bristol-Myers Squibb. Carol Brosgart was an
employee of Gilead Sciences, Inc. from June 1998 through July 1, 2009.
Carol Brosgart owns stocks and shares in Gilead Sciences, Inc. Robert
Gish has served as a speaker and consultant for Bristol-Myers Squibb,
Gilead Sciences, Inc. and Roche, and all payments are made to a research
and educational fund at California Pacific Medical Center.
NR 59
TC 62
Z9 62
U1 0
U2 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1352-0504
J9 J VIRAL HEPATITIS
JI J. Viral Hepatitis
PD JUN
PY 2011
VL 18
IS 6
BP 377
EP 383
DI 10.1111/j.1365-2893.2010.01401.x
PG 7
WC Gastroenterology & Hepatology; Infectious Diseases; Virology
SC Gastroenterology & Hepatology; Infectious Diseases; Virology
GA 755AJ
UT WOS:000289898700001
PM 21143343
ER
PT J
AU Ma, Q
Lu, AYH
AF Ma, Qiang
Lu, Anthony Y. H.
TI Pharmacogenetics, Pharmacogenomics, and Individualized Medicine
SO PHARMACOLOGICAL REVIEWS
LA English
DT Review
ID HUMAN UDP-GLUCURONOSYLTRANSFERASES; POLYMORPHISM MARKEDLY AFFECTS;
BREAST-CANCER-TREATMENT; ADVERSE DRUG-REACTIONS; K EPOXIDE REDUCTASE;
OATP-C SLC21A6; GENETIC POLYMORPHISMS; PERSONALIZED MEDICINE;
CLINICAL-OUTCOMES; ALLELIC VARIANTS
AB Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug therapy. The convergence of pharmacogenetics and human genomics in recent years has dramatically accelerated the discovery of new genetic variations that potentially underlie variability in drug response, giving birth to pharmacogenomics. In addition to the rapid accumulation of knowledge on genome-disease and genome-drug interactions, there arises the hope of individualized medicine. Here we review recent progress in the understanding of genetic contributions to major individual variability in drug therapy with focus on genetic variations of drug target, drug metabolism, drug transport, disease susceptibility, and drug safety. Challenges to future pharmacogenomics and its translation into individualized medicine, drug development, and regulation are discussed. For example, knowledge on genetic determinants of disease pathogenesis and drug action, especially those of complex disease and drug response, is not always available. Relating the many gene variations from genomic sequencing to clinical phenotypes may not be straightforward. It is often very challenging to conduct large scale, prospective studies to establish causal associations between genetic variations and drug response or to evaluate the utility and cost-effectiveness of genomic medicine. Overcoming the obstacles holds promise for achieving the ultimate goal of effective and safe medication to targeted patients with appropriate genotypes.
C1 [Ma, Qiang] NIOSH, Receptor Biol Lab, Toxicol & Mol Biol Branch, Hlth Effects Lab Div,Ctr Dis Control & Prevent,, Morgantown, WV 26505 USA.
[Lu, Anthony Y. H.] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Piscataway, NJ USA.
RP Ma, Q (reprint author), NIOSH, Receptor Biol Lab, Toxicol & Mol Biol Branch, Hlth Effects Lab Div,Ctr Dis Control & Prevent,, 1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM qam1@cdc.gov
NR 115
TC 151
Z9 161
U1 10
U2 73
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0031-6997
J9 PHARMACOL REV
JI Pharmacol. Rev.
PD JUN
PY 2011
VL 63
IS 2
BP 437
EP 459
DI 10.1124/pr.110.003533
PG 23
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 754VI
UT WOS:000289885400008
PM 21436344
ER
PT J
AU Yen, C
Jakob, K
Esona, MD
Peckham, X
Rausch, J
Hull, JJ
Whittier, S
Gentsch, JR
LaRussa, P
AF Yen, Catherine
Jakob, Kathleen
Esona, Mathew D.
Peckham, Ximara
Rausch, John
Hull, Jennifer J.
Whittier, Susan
Gentsch, Jon R.
LaRussa, Philip
TI Detection of fecal shedding of rotavirus vaccine in infants following
their first dose of pentavalent rotavirus vaccine
SO VACCINE
LA English
DT Article
DE Gastroenteritis; Rotavirus; Vaccine
ID SEVERE COMBINED IMMUNODEFICIENCY; TRANSPLANT RECIPIENTS; INFECTION;
GASTROENTERITIS; VOLUNTEERS; CHILDREN; ILLNESS; ASSAY; WC3
AB Studies on rotavirus vaccine shedding and its potential transmission within households including immunocompromised individuals are needed to better define the potential risks and benefits of vaccination. We examined fecal shedding of pentavalent rotavirus vaccine (RV5) for 9 days following the first dose of vaccine in infants between 6 and 12 weeks of age. Rotavirus antigen was detected by enzyme immunoassay (EIA), and vaccine-type rotavirus was identified by nucleotide sequencing based on genetic relatedness to the RV5 VP6 gene. Stool from 22 (21.4%) of 103 children contained rotavirus antigen-positive specimens on >= 1 post-vaccination days. Rotavirus antigen was detected as early as post-vaccination day 3 and as late as day 9, with peak numbers of shedding on post-vaccination days 6 through 8. Vaccine-type rotavirus was detected in all 50 antigen-positive specimens and 8 of 8 antigen-negative specimens. Nine (75%) of 12 EIA-positive and 1 EIA-negative samples tested culture-positive for vaccine-type rotavirus. Fecal shedding of rotavirus vaccine virus after the first dose of RV5 occurred over a wide range of post-vaccination days not previously studied. These findings will help better define the potential for horizontal transmission of vaccine virus among immunocompromised household contacts of vaccinated infants for future studies. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Yen, Catherine; Jakob, Kathleen; Peckham, Ximara; Rausch, John; LaRussa, Philip] Columbia Univ, Dept Pediat, New York, NY 10027 USA.
[Esona, Mathew D.; Hull, Jennifer J.; Gentsch, Jon R.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA.
[Whittier, Susan] Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA.
RP LaRussa, P (reprint author), Columbia Univ Coll Phys & Surg, Black Bldg 4-433,630 W 168th St, New York, NY 10032 USA.
EM plarussa@columbia.edu
FU Centers for Disease Control and Prevention (CDC) [200-2002-00732]
FX This study was funded by the Clinical Immunization and Safety Assessment
(CISA) network through a subcontract with America's Health Insurance
Plans (AHIP) under contract 200-2002-00732 from the Centers for Disease
Control and Prevention (CDC).
NR 27
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U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD MAY 31
PY 2011
VL 29
IS 24
BP 4151
EP 4155
DI 10.1016/j.vaccine.2011.03.074
PG 5
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 784RV
UT WOS:000292176800011
PM 21477676
ER
PT J
AU Patterson, DG
Welch, SM
Turner, WE
Sjodin, A
Focant, JF
AF Patterson, Donald G., Jr.
Welch, Susan M.
Turner, Wayman E.
Sjoedin, Andreas
Focant, Jean-Francois
TI Cryogenic zone compression for the measurement of dioxins in human serum
by isotope dilution at the attogram level using modulated gas
chromatography coupled to high resolution magnetic sector mass
spectrometry
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article; Proceedings Paper
CT 34th International Symposium on Capillary Chromatography (ISCC)/7th
GCxGC Symposium
CY MAY 30-JUN 04, 2010
CL Riva del Garda, ITALY
DE Cryogenic zone compression (CZC); Comprehensive two-dimensional gas
chromatography (GC x GC); High resolution mass spectrometry (HRMS);
Dioxins; DDE; BB153; Human serum; Dried-blood spot (DBS)
ID GC X GC; POLYCHLORINATED-BIPHENYLS; THERMAL MODULATION; PESTICIDES;
SEPARATION; OPTIMIZATION; ENHANCEMENT; FOODSTUFFS; AMPLITUDE; PCBS
AB A liquid nitrogen jet-cooled thermal modulator dedicated to comprehensive two-dimensional gas chromatography has been mounted in a GC oven coupled to a high resolution magnetic sector mass spectrometry instrument. The data acquisition parameters of the slow double-focusing magnetic sector MS instrument have been optimized to accommodate the description of the narrow modulated GC peaks. Acquisition rates were increased to 20 Hz, while maintaining high mass resolution. Selected ion monitoring (SIM) descriptors, typically including several ions for both native and labeled analytes, were thus reduced to one or two to ensure enough MS cycle time. For maximization of the sensitivity enhancement due to cryogenic zone compression (CZC), the entire GC peak of interest was trapped and remobilized in one event. Optimization of the method resulted in the ability to detect low attogram (ag) amounts of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) (313 ag gives a S/N of 400:1), a level that had not yet been attained using classical GC-HRMS. An isotope-dilution calibration curve was constructed using C-13(12)-2,3,7,8-TCDD as the internal standard over the range of 500 ag/mu L to 35,000 ag/mu L. (R-2 = 0.9953). Analyses of a standard natural human reference serum-matrix NIST SRM 1589a containing 223 ag of 1,2,3,7,8-pentachlorodibenzo-p-dioxin (1,2,3,7,8-PeCDD) (70% recovery rate assumed) resulted in a peak with a S/N of 188:1(4 sigma, m/z = 355.8546). Measurement of 2,2-bis (4-chlorophenyl-1,1,1-trichloroethane) (DDE) and 2,2',4,4',5,5'-hexabromobiphenyl (BB-153) in human dried-blood spot (DBS) samples is also reported to illustrate the usefulness of such a sensitive technique. Finally, some of the challenges related to sample preparation, blank levels, and to the fact of measuring of such a limited number of molecules (less than 600,000 TCDD molecules) are discussed. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Patterson, Donald G., Jr.] EnviroSolut Consulting Inc, Jasper, GA 30143 USA.
[Welch, Susan M.; Turner, Wayman E.; Sjoedin, Andreas] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Focant, Jean-Francois] Univ Liege, Dept Chem, Mass Spectrometry Lab, CART, B-4000 Liege, Belgium.
RP Patterson, DG (reprint author), EnviroSolut Consulting Inc, 172 Camelot Way,20198, Jasper, GA 30143 USA.
EM donpatt@etcmail.com
RI Sjodin, Andreas/F-2464-2010
NR 35
TC 25
Z9 25
U1 1
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0021-9673
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD MAY 27
PY 2011
VL 1218
IS 21
SI SI
BP 3274
EP 3281
DI 10.1016/j.chroma.2010.10.084
PG 8
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 767UG
UT WOS:000290883000022
PM 21112056
ER
PT J
AU Thigpen, MC
Whitney, CG
Messonnier, NE
Zell, ER
Lynfield, R
Hadler, JL
Harrison, LH
Farley, MM
Reingold, A
Bennett, NM
Craig, AS
Schaffner, W
Thomas, A
Lewis, MM
Scallan, E
Schuchat, A
AF Thigpen, Michael C.
Whitney, Cynthia G.
Messonnier, Nancy E.
Zell, Elizabeth R.
Lynfield, Ruth
Hadler, James L.
Harrison, Lee H.
Farley, Monica M.
Reingold, Arthur
Bennett, Nancy M.
Craig, Allen S.
Schaffner, William
Thomas, Ann
Lewis, Melissa M.
Scallan, Elaine
Schuchat, Anne
CA Emerging Infections Programs Netw
TI Bacterial Meningitis in the United States, 1998-2007
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID PNEUMOCOCCAL CONJUGATE VACCINE; SURVEILLANCE; LISTERIOSIS; DISEASE;
EPIDEMIOLOGY; ILLNESS; NETWORK; ADULTS
AB BACKGROUND
The rate of bacterial meningitis declined by 55% in the United States in the early 1990s, when the Haemophilus influenzae type b (Hib) conjugate vaccine for infants was introduced. More recent prevention measures such as the pneumococcal conjugate vaccine and universal screening of pregnant women for group B streptococcus (GBS) have further changed the epidemiology of bacterial meningitis.
METHODS
We analyzed data on cases of bacterial meningitis reported among residents in eight surveillance areas of the Emerging Infections Programs Network, consisting of approximately 17.4 million persons, during 1998-2007. We defined bacterial meningitis as the presence of H. influenzae, Streptococcus pneumoniae, GBS, Listeria monocytogenes, or Neisseria meningitidis in cerebrospinal fluid or other normally sterile site in association with a clinical diagnosis of meningitis.
RESULTS
We identified 3188 patients with bacterial meningitis; of 3155 patients for whom outcome data were available, 466 (14.8%) died. The incidence of meningitis changed by -31% (95% confidence interval [CI], -33 to -29) during the surveillance period, from 2.00 cases per 100,000 population (95% CI, 1.85 to 2.15) in 1998-1999 to 1.38 cases per 100,000 population (95% CI 1.27 to 1.50) in 2006-2007. The median age of patients increased from 30.3 years in 1998-1999 to 41.9 years in 2006-2007 (P<0.001 by the Wilcoxon rank-sum test). The case fatality rate did not change significantly: it was 15.7% in 1998-1999 and 14.3% in 2006-2007 (P=0.50). Of the 1670 cases reported during 2003-2007, S. pneumoniae was the predominant infective species (58.0%), followed by GBS (18.1%), N. meningitidis (13.9%), H. influenzae (6.7%), and L. monocytogenes (3.4%). An estimated 4100 cases and 500 deaths from bacterial meningitis occurred annually in the United States during 2003-2007.
CONCLUSIONS
The rates of bacterial meningitis have decreased since 1998, but the disease still often results in death. With the success of pneumococcal and Hib conjugate vaccines in reducing the risk of meningitis among young children, the burden of bacterial meningitis is now borne more by older adults. (Funded by the Emerging Infections Programs, Centers for Disease Control and Prevention.)
C1 [Thigpen, Michael C.; Whitney, Cynthia G.; Messonnier, Nancy E.; Zell, Elizabeth R.; Lewis, Melissa M.; Scallan, Elaine; Schuchat, Anne] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Farley, Monica M.] Georgia Dept Human Resources, Atlanta, GA USA.
[Lynfield, Ruth] Minnesota Dept Hlth, Minneapolis, MN USA.
[Hadler, James L.] Connecticut Dept Publ Hlth & Addict Serv, Hartford, CT 06106 USA.
[Harrison, Lee H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Reingold, Arthur] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
[Bennett, Nancy M.] Univ Rochester, Sch Med & Dent, Rochester, NY USA.
[Craig, Allen S.; Schaffner, William] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
[Thomas, Ann] Oregon Publ Hlth Div, Portland, OR USA.
RP Thigpen, MC (reprint author), 3150 Rampart Rd, Ft Collins, CO 80521 USA.
EM mthigpen@cdc.gov
FU Centers for Disease Control and Prevention, Atlanta
FX Supported by the Emerging Infections Programs, Centers for Disease
Control and Prevention, Atlanta.
NR 32
TC 244
Z9 257
U1 3
U2 24
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD MAY 26
PY 2011
VL 364
IS 21
BP 2016
EP 2025
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA 768QR
UT WOS:000290952000006
PM 21612470
ER
PT J
AU Viner, K
Johnson, CC
Newbern, EC
Dickman, B
Dettinger, L
Waller, K
Sales, R
Mitruka, K
Magee, E
Grant, J
Manangan, L
Yelk-Woodruff, R
Ershova, J
Metchock, B
Bedell, D
Avant, W
Dohony, D
Cropper, TC
Haddad, M
Jones, J
Rosen, T
Click, E
Willis, M
Abraham, B
AF Viner, K.
Johnson, C. C.
Newbern, E. C.
Dickman, B.
Dettinger, L.
Waller, K.
Sales, R.
Mitruka, K.
Magee, E.
Grant, J.
Manangan, L.
Yelk-Woodruff, R.
Ershova, J.
Metchock, B.
Bedell, D.
Avant, W.
Dohony, D.
Cropper, T. C.
Haddad, M.
Jones, J.
Rosen, T.
Click, E.
Willis, M.
Abraham, B.
TI Assessment of Declines in Reported Tuberculosis Cases-Georgia and
Pennsylvania, 2009 (Reprinted from MMWR, vol 60, pg 338-342, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Viner, K.; Johnson, C. C.; Newbern, E. C.; Dickman, B.] Philadelphia Dept Publ Hlth, Philadelphia, PA 19107 USA.
[Dettinger, L.; Waller, K.] Penn Dept Hlth, Harrisburg, PA 17108 USA.
[Sales, R.] Georgia Dept Community Hlth, Atlanta, GA USA.
[Click, E.; Willis, M.; Abraham, B.] CDC, Atlanta, GA 30333 USA.
RP Viner, K (reprint author), Philadelphia Dept Publ Hlth, Philadelphia, PA 19107 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAY 25
PY 2011
VL 305
IS 20
BP 2059
EP 2062
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 768AC
UT WOS:000290901700009
ER
PT J
AU Li, CY
Ford, ES
Tsai, J
Zhao, GX
Balluz, LS
Gidding, SS
AF Li, Chaoyang
Ford, Earl S.
Tsai, James
Zhao, Guixiang
Balluz, Lina S.
Gidding, Samuel S.
TI Serum Non-high-density lipoprotein cholesterol concentration and risk of
death from cardiovascular diseases among US adults with diagnosed
diabetes: the Third National Health and Nutrition Examination Survey
linked mortality study
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE lipids; lipoproteins; mortality; diabetes mellitus; cardiovascular
diseases
ID CORONARY-HEART-DISEASE; NON-HDL CHOLESTEROL; ISCHEMIC-STROKE;
MYOCARDIAL-INFARCTION; APOLIPOPROTEIN-B; LIPID-LEVELS; ASSOCIATION;
WOMEN; MEN; ATHEROSCLEROSIS
AB Background: Non-high-density lipoprotein cholesterol (non-HDL-C) measures all atherogenic apolipoprotein B-containing lipoproteins and predicts risk of cardiovascular diseases (CVD). The association of non-HDL-C with risk of death from CVD in diabetes is not well understood. This study assessed the hypothesis that, among adults with diabetes, non-HDL-C may be related to the risk of death from CVD.
Methods: We analyzed data from 1,122 adults aged 20 years and older with diagnosed diabetes who participated in the Third National Health and Nutrition Examination Survey linked mortality study (299 deaths from CVD according to underlying cause of death; median follow-up length, 12.4 years).
Results: Compared to participants with serum non-HDL-C concentrations of 35 to 129 mg/dL, those with higher serum levels had a higher risk of death from total CVD: the RRs were 1.34 (95% CI: 0.75-2.39) and 2.25 (95% CI: 1.30-3.91) for non-HDL-C concentrations of 130-189 mg/dL and 190-403 mg/dL, respectively (P = 0.003 for linear trend) after adjustment for demographic characteristics and selected risk factors. In subgroup analyses, significant linear trends were identified for the risk of death from ischemic heart disease: the RRs were 1.59 (95% CI: 0.76-3.32) and 2.50 (95% CI: 1.28-4.89) (P = 0.006 for linear trend), and stroke: the RRs were 3.37 (95% CI: 0.95-11.90) and 5.81 (95% CI: 1.96-17.25) (P = 0.001 for linear trend).
Conclusions: In diabetics, higher serum non-HDL-C concentrations were significantly associated with increased risk of death from CVD. Our prospective data support the notion that reducing serum non-HDL-C concentrations may be beneficial in the prevention of excess death from CVD among affected adults.
C1 [Li, Chaoyang; Balluz, Lina S.] Ctr Dis Control & Prevent, Div Behav Surveillance, Atlanta, GA 30333 USA.
[Ford, Earl S.; Zhao, Guixiang] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Atlanta, GA USA.
[Tsai, James] Ctr Dis Control & Prevent, Div Blood Disorders, Atlanta, GA USA.
[Gidding, Samuel S.] Alfred I DuPont Hosp Children, Nemours Cardiac Ctr, Wilmington, DE USA.
RP Li, CY (reprint author), Ctr Dis Control & Prevent, Div Behav Surveillance, Atlanta, GA 30333 USA.
EM cli@cdc.gov
NR 44
TC 15
Z9 16
U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD MAY 23
PY 2011
VL 10
AR 46
DI 10.1186/1475-2840-10-46
PG 12
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 786JW
UT WOS:000292304600001
PM 21605423
ER
PT J
AU Wasse, H
Cardarelli, F
De Staercke, C
Hooper, C
Veledar, E
Guessous, I
AF Wasse, Haimanot
Cardarelli, Francesca
De Staercke, Christine
Hooper, Craig
Veledar, Emir
Guessous, Idris
TI 25-hydroxyvitamin D concentration is inversely associated with serum
MMP-9 in a cross-sectional study of African American ESRD patients
SO BMC NEPHROLOGY
LA English
DT Article
ID ABDOMINAL AORTIC-ANEURYSM; VITAMIN-D; MATRIX METALLOPROTEINASES;
HEMODIALYSIS-PATIENTS; MYOCARDIAL-INFARCTION; CIRCULATING LEVELS;
DIALYSIS PATIENTS; DOUBLE-BLIND; IN-VITRO; INFLAMMATION
AB Background: Circulating 25-hydroxyvitamin D [25(OH)D] concentration is inversely associated with peripheral arterial disease and hypertension. Vascular remodeling may play a role in this association, however, data relating vitamin D level to specific remodeling biomarkers among ESRD patients is sparse. We tested whether 25(OH)D concentration is associated with markers of vascular remodeling and inflammation in African American ESRD patients.
Methods: We conducted a cross-sectional study among ESRD patients receiving maintenance hemodialysis within Emory University-affiliated outpatient hemodialysis units. Demographic, clinical and dialysis treatment data were collected via direct patient interview and review of patients records at the time of enrollment, and each patient gave blood samples. Associations between 25(OH)D and biomarker concentrations were estimated in univariate analyses using Pearson's correlation coefficients and in multivariate analyses using linear regression models. 25(OH)D concentration was entered in multivariate linear regression models as a continuous variable and binary variable (< 15 ng/ml and >= 15 ng/ml). Adjusted estimate concentrations of biomarkers were compared between 25(OH) D groups using analysis of variance (ANOVA). Finally, results were stratified by vascular access type.
Results: Among 91 patients, mean (standard deviation) 25(OH)D concentration was 18.8 (9.6) ng/ml, and was low (< 15 ng/ml) in 43% of patients. In univariate analyses, low 25(OH) D was associated with lower serum calcium, higher serum phosphorus, and higher LDL concentrations. 25(OH) D concentration was inversely correlated with MMP-9 concentration (r = -0.29, p = 0.004). In multivariate analyses, MMP-9 concentration remained negatively associated with 25(OH) D concentration (P = 0.03) and anti-inflammatory IL-10 concentration positively correlated with 25(OH) D concentration (P = 0.04).
Conclusions: Plasma MMP-9 and circulating 25(OH) D concentrations are significantly and inversely associated among ESRD patients. This finding may suggest a potential mechanism by which low circulating 25(OH) D functions as a cardiovascular risk factor.
C1 [Wasse, Haimanot; Guessous, Idris] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
[Wasse, Haimanot] Emory Univ, Div Nephrol, Atlanta, GA 30322 USA.
[Cardarelli, Francesca; Veledar, Emir] Emory Univ, Div Cardiol, Atlanta, GA 30322 USA.
[De Staercke, Christine; Hooper, Craig] Ctr Dis Control & Prevent, Div Blood Disorders, Atlanta, GA USA.
[Guessous, Idris] Univ Hosp Geneva, Unit Populat Epidemiol, Div Primary Care Med, Dept Community Med Primary Care & Emergency Med, Geneva, Switzerland.
[Guessous, Idris] Univ Lausanne Hosp, Community Prevent Unit, Univ Inst Social & Prevent Med IUMSP, Lausanne, Switzerland.
RP Guessous, I (reprint author), Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
EM idris.guessous@chuv.ch
RI Veledar, Emir/K-2808-2012; Wasse, Haimanot/A-5726-2013
OI Veledar, Emir/0000-0002-3831-5433; Wasse, Haimanot/0000-0001-5756-0242
FU NIH [DK65634]; Davita Clinical Research Grant; National Institutes of
Health, National Center for Research Resources [UL1 RR02008, KL2
RR025009, TL1 RR025010]; Swiss Foundation for Science [33CM30-124087]
FX This study was supported by an NIH K23 Grant DK65634 (H.W.), a Davita
Clinical Research Grant (H.W.), and a PHS Grant (UL1 RR02008, KL2
RR025009 or TL1 RR025010) from the Clinical and Translational Science
Award program, National Institutes of Health, National Center for
Research Resources. Additional support (I.G.) was provided by a grant
from the Swiss Foundation for Science (33CM30-124087).
NR 31
TC 16
Z9 17
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2369
J9 BMC NEPHROL
JI BMC Nephrol.
PD MAY 22
PY 2011
VL 12
AR 24
DI 10.1186/1471-2369-12-24
PG 9
WC Urology & Nephrology
SC Urology & Nephrology
GA 946NS
UT WOS:000304359300002
PM 21600051
ER
PT J
AU Prabhu, VS
Farnham, PG
Hutchinson, AB
Soorapanth, S
Heffelfinger, JD
Golden, MR
Brooks, JT
Rimland, D
Sansom, SL
AF Prabhu, Vimalanand S.
Farnham, Paul G.
Hutchinson, Angela B.
Soorapanth, Sada
Heffelfinger, James D.
Golden, Matthew R.
Brooks, John T.
Rimland, David
Sansom, Stephanie L.
TI Cost-Effectiveness of HIV Screening in STD Clinics, Emergency
Departments, and Inpatient Units: A Model-Based Analysis
SO PLOS ONE
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; ADJUSTED
LIFE-YEAR; COLLABORATIVE ANALYSIS; HIV-1-INFECTED PATIENTS; INFECTED
PERSONS; MEDICAL-CARE; STATES; TRANSMISSION; COHORT
AB Background: Identifying and treating persons with human immunodeficiency virus (HIV) infection early in their disease stage is considered an effective means of reducing the impact of the disease. We compared the cost-effectiveness of HIV screening in three settings, sexually transmitted disease (STD) clinics serving men who have sex with men, hospital emergency departments (EDs), settings where patients are likely to be diagnosed early, and inpatient diagnosis based on clinical manifestations.
Methods and Findings: We developed the Progression and Transmission of HIV/AIDS model, a health state transition model that tracks index patients and their infected partners from HIV infection to death. We used program characteristics for each setting to compare the incremental cost per quality-adjusted life year gained from early versus late diagnosis and treatment. We ran the model for 10,000 index patients for each setting, examining alternative scenarios, excluding and including transmission to partners, and assuming HAART was initiated at a CD4 count of either 350 or 500 cells/mu L. Screening in STD clinics and EDs was cost-effective compared with diagnosing inpatients, even when including only the benefits to the index patients. Screening patients in STD clinics, who have less-advanced disease, was cost-effective compared with ED screening when treatment with HAART was initiated at a CD4 count of 500 cells/mu L. When the benefits of reduced transmission to partners from early diagnosis were included, screening in settings with less-advanced disease stages was cost-saving compared with screening later in the course of infection. The study was limited by a small number of observations on CD4 count at diagnosis and by including transmission only to first generation partners of the index patients.
Conclusions: HIV prevention efforts can be advanced by screening in settings where patients present with less-advanced stages of HIV infection and by initiating treatment with HAART earlier in the course of infection.
C1 [Prabhu, Vimalanand S.] Ctr Dis Control & Prevent CDC, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA USA.
[Farnham, Paul G.; Hutchinson, Angela B.; Heffelfinger, James D.; Brooks, John T.; Sansom, Stephanie L.] Ctr Dis Control & Prevent CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div HIV AIDS Prevent, Atlanta, GA USA.
[Soorapanth, Sada] San Francisco State Univ, San Francisco, CA 94132 USA.
[Golden, Matthew R.] Univ Washington, Publ Health Seattle & King Cty STD Clin, Seattle, WA 98195 USA.
[Golden, Matthew R.] Univ Washington, Ctr AIDS & STD, Seattle, WA 98195 USA.
[Rimland, David] Vet Affairs Med Ctr, Med Specialty Serv Line RIM 111, Decatur, GA 30033 USA.
[Rimland, David] Emory Univ, Sch Med, Atlanta, GA USA.
RP Prabhu, VS (reprint author), Ctr Dis Control & Prevent CDC, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA USA.
EM pgf1@cdc.gov
OI Soorapanth, Sada/0000-0002-0644-9082
NR 53
TC 13
Z9 13
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 20
PY 2011
VL 6
IS 5
AR e19936
DI 10.1371/journal.pone.0019936
PG 11
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 766OI
UT WOS:000290793400020
PM 21625489
ER
PT J
AU Mirza, AM
Aguilar, HC
Zhu, QY
Mahon, PJ
Rota, PA
Lee, B
Iorio, RM
AF Mirza, Anne M.
Aguilar, Hector C.
Zhu, Qiyun
Mahon, Paul J.
Rota, Paul A.
Lee, Benhur
Iorio, Ronald M.
TI Triggering of the Newcastle Disease Virus Fusion Protein by a Chimeric
Attachment Protein That Binds to Nipah Virus Receptors
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN; REPORTER GENE ACTIVATION;
HENDRA-VIRUS; CELL-FUSION; MONOCLONAL-ANTIBODIES; HN PROTEIN; FUNCTIONAL
INTERACTION; PARAMYXOVIRUS FUSION; MEMBRANE-FUSION; VIRAL ENTRY
AB The fusion (F) proteins of Newcastle disease virus (NDV) and Nipah virus (NiV) are both triggered by binding to receptors, mediated in both viruses by a second protein, the attachment protein. However, the hemagglutinin-neuraminidase (HN) attachment protein of NDV recognizes sialic acid receptors, whereas the NiV G attachment protein recognizes ephrinB2/B3 as receptors. Chimeric proteins composed of domains from the two attachment proteins have been evaluated for fusion-promoting activity with each F protein. Chimeras having NiV G-derived globular domains and NDV HN-derived stalks, transmembranes, and cytoplasmic tails are efficiently expressed, bind ephrinB2, and trigger NDV F to promote fusion in Vero cells. Thus, the NDV F protein can be triggered by binding to the NiV receptor, indicating that an aspect of the triggering cascade induced by the binding of HN to sialic acid is conserved in the binding of NiV G to ephrinB2. However, the fusion cascade for triggering NiV F by the G protein and that of triggering NDV F by the chimeras can be distinguished by differential exposure of a receptor-induced conformational epitope. The enhanced exposure of this epitope marks the triggering of NiV F by NiV G but not the triggering of NDV F by the chimeras. Thus, the triggering cascade for NiV G-F fusion may be more complex than that of NDV HN and F. This is consistent with the finding that reciprocal chimeras having NDV HN-derived heads and NiV G-derived stalks, transmembranes, and tails do not trigger either F protein for fusion, despite efficient cell surface expression and receptor binding.
C1 [Mirza, Anne M.; Zhu, Qiyun; Mahon, Paul J.; Iorio, Ronald M.] Univ Massachusetts, Sch Med, Dept Microbiol & Physiol Syst, Worcester, MA 01655 USA.
[Iorio, Ronald M.] Univ Massachusetts, Sch Med, Program Immunol & Virol, Worcester, MA 01655 USA.
[Aguilar, Hector C.; Lee, Benhur] Univ Calif Los Angeles, David Geffen Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA.
[Rota, Paul A.] Ctr Dis Control & Prevent, Measles Mumps Rubella & Herpesvirus Lab Branch, Atlanta, GA 30333 USA.
RP Iorio, RM (reprint author), Univ Massachusetts, Sch Med, Dept Microbiol & Physiol Syst, 55 Lake Ave N, Worcester, MA 01655 USA.
EM ronald.iorio@umassmed.edu
RI Lee, Benhur/A-8554-2016
OI Lee, Benhur/0000-0003-0760-1709
FU National Institutes of Health [AI49268]; Pacific Southwest Regional
Center for Excellence in Biodefense and Emerging Infectious Diseases
[U54 AI065359]
FX This work was supported, in whole or in part, by National Institutes of
Health Grant AI49268 (to R. M. I.), a subproject of U19 Grant AI057319
(to the University of Massachusetts Center for Translational Research on
Human Immunology and Biodefense), and AI069317 (to B. L.). This work was
also supported by Subproject Award U54 AI065359 from the Pacific
Southwest Regional Center for Excellence in Biodefense and Emerging
Infectious Diseases.
NR 42
TC 21
Z9 21
U1 0
U2 2
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAY 20
PY 2011
VL 286
IS 20
BP 17851
EP 17860
DI 10.1074/jbc.M111.233965
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 763UM
UT WOS:000290585200048
PM 21460213
ER
PT J
AU Schenker, N
Parsons, VL
Lochner, KA
Wheatcroft, G
Pamuk, ER
AF Schenker, Nathaniel
Parsons, Van L.
Lochner, Kimberly A.
Wheatcroft, Gloria
Pamuk, Elsie R.
TI Estimating standard errors for life expectancies based on complex survey
data with mortality follow-up: A case study using the National Health
Interview Survey Linked Mortality Files
SO STATISTICS IN MEDICINE
LA English
DT Article
DE balanced repeated replication; health disparity; life table; sample
survey; Taylor series; variance estimation
ID LONGITUDINAL MORTALITY; EDUCATION
AB Life expectancy is an important measure for health research and policymaking. Linking individual survey records to mortality data can overcome limitations in vital statistics data used to examine differential mortality by permitting the construction of death rates based on information collected from respondents at the time of interview and facilitating estimation of life expectancies for subgroups of interest. However, use of complex survey data linked to mortality data can complicate the estimation of standard errors. This paper presents a case study of approaches to variance estimation for life expectancies based on life tables, using the National Health Interview Survey Linked Mortality Files. The approaches considered include application of Chiang's traditional method, which is straightforward but does not account for the complex design features of the data; balanced repeated replication (BRR), which is more complicated but accounts more fully for the design features; and compromise, 'hybrid' approaches, which can be less difficult to implement than BRR but still account partially for the design features. Two tentative conclusions are drawn. First, it is important to account for the effects of the complex sample design, at least within life-table age intervals. Second, accounting for the effects within age intervals but not across age intervals, as is done by the hybrid methods, can yield reasonably accurate estimates of standard errors, especially for subgroups of interest with more homogeneous characteristics among their members. Published in 2011 by John Wiley & Sons, Ltd.
C1 [Schenker, Nathaniel; Parsons, Van L.; Lochner, Kimberly A.; Wheatcroft, Gloria; Pamuk, Elsie R.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
RP Schenker, N (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd, Hyattsville, MD 20782 USA.
EM nschenker@cdc.gov
NR 30
TC 1
Z9 1
U1 0
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0277-6715
J9 STAT MED
JI Stat. Med.
PD MAY 20
PY 2011
VL 30
IS 11
BP 1302
EP 1311
DI 10.1002/sim.4219
PG 10
WC Mathematical & Computational Biology; Public, Environmental &
Occupational Health; Medical Informatics; Medicine, Research &
Experimental; Statistics & Probability
SC Mathematical & Computational Biology; Public, Environmental &
Occupational Health; Medical Informatics; Research & Experimental
Medicine; Mathematics
GA 762IP
UT WOS:000290470100010
PM 21432895
ER
PT J
AU Halpern, MT
Haber, SG
Tangka, FK
Howard, DH
Richardson, LC
Sabatino, SA
Sujha, S
AF Halpern, M. T.
Haber, S. G.
Tangka, F. K.
Howard, D. H.
Richardson, L. C.
Sabatino, S. A.
Sujha, S.
TI Changes in Medicaid reimbursements for cancer screening: Keeping pace
with inflation?
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
C1 RTI Int, Washington, DC USA.
RTI Int, Waltham, MA USA.
Ctr Dis Control & Prevent, DCPC EARB, Atlanta, GA USA.
Emory Univ, Dept Hlth Policy & Management, Atlanta, GA 30322 USA.
Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2011
VL 29
IS 15
SU S
MA 6043
PG 1
WC Oncology
SC Oncology
GA V31JQ
UT WOS:000208880301756
PM 28021899
ER
PT J
AU Underwood, JM
Rim, SH
Tai, E
Fairley, T
AF Underwood, J. M.
Rim, S. H.
Tai, E.
Fairley, T.
TI The risk of subsequent malignancies in cervical cancer survivors as
compared with breast and colorectal cancer survivors: United States
1992-2007.
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
C1 Ctr Dis Control & Prevent, Atlanta, GA USA.
Ctr Dis Control, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2011
VL 29
IS 15
SU S
MA 9043
PG 1
WC Oncology
SC Oncology
GA V31JQ
UT WOS:000208880302474
PM 28021634
ER
PT J
AU Wheeler, SB
Wu, Y
Meyer, A
Carpenter, WR
Richardson, LC
Smith, JL
Lewis, MA
Weiner, B
AF Wheeler, S. B.
Wu, Y.
Meyer, A.
Carpenter, W. R.
Richardson, L. C.
Smith, J. L.
Lewis, M. A.
Weiner, B.
TI Use of radiation therapy after breast-conserving surgery among Medicaid
recipients with early-stage breast cancer
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Meeting Abstract
C1 Univ N Carolina, Chapel Hill, NC USA.
Ctr Dis Control & Prevent, Atlanta, GA USA.
RTI Int, Res Triangle Pk, NC USA.
RI Carpenter, William/E-5125-2013
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2011
VL 29
IS 15
SU S
MA 6097
PG 1
WC Oncology
SC Oncology
GA V31JQ
UT WOS:000208880300772
PM 28022418
ER
PT J
AU Cocoros, NM
Zipprich, J
Kuhles, D
Rausch-Phung, E
Schulte, CR
Blog, DS
Lurie, P
Wiseman, R
Kroll, C
DeBolt, C
Kutty, PK
Redd, SB
Barskey, AE
Rota, JS
Rota, PA
Armstrong, GL
Bellini, WJ
Gallagher, KM
Mahamud, AS
AF Cocoros, N. M.
Zipprich, J.
Kuhles, D.
Rausch-Phung, E.
Schulte, C. R.
Blog, D. S.
Lurie, P.
Wiseman, R.
Kroll, C.
DeBolt, C.
Kutty, P. K.
Redd, S. B.
Barskey, A. E.
Rota, J. S.
Rota, P. A.
Armstrong, G. L.
Bellini, W. J.
Gallagher, K. M.
Mahamud, A. S.
TI Measles Imported by Returning U.S. Travelers Aged 6-23 Months, 2001-2011
(Reprinted from MMWR, vol 60, pg 397-400, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
ID UNITED-STATES
C1 [Kutty, P. K.; Redd, S. B.; Barskey, A. E.; Rota, J. S.; Rota, P. A.; Armstrong, G. L.; Bellini, W. J.; Gallagher, K. M.] CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Cocoros, N. M.] Massachusetts Dept Publ Hlth, Boston, MA 02111 USA.
[Zipprich, J.] Calif Dept Publ Hlth, Richmond, CA USA.
[Rausch-Phung, E.; Schulte, C. R.; Blog, D. S.] New York State Dept Hlth, Albany, NY 12237 USA.
[Lurie, P.] Penn Dept Hlth, Harrisburg, PA 17108 USA.
[Wiseman, R.] Texas Dept State Hlth Svcs, Austin, TX USA.
[Kroll, C.] Clark Cty Publ Hlth, Vancouver, WA USA.
[DeBolt, C.] Washington State Dept Hlth, Washington, DC USA.
RP Kutty, PK (reprint author), CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
EM pkutty@cdc.gov
NR 11
TC 0
Z9 0
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAY 18
PY 2011
VL 305
IS 19
BP 1954
EP 1956
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 764WO
UT WOS:000290665500010
ER
PT J
AU Wheaton, AG
Liu, Y
Perry, GS
Croft, JB
AF Wheaton, A. G.
Liu, Y.
Perry, G. S.
Croft, J. B.
TI Effect of Short Sleep Duration on Daily Activities-United States,
2005-2008 (Reprinted from MMWR, vol 60, pg 239-242, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Wheaton, A. G.; Liu, Y.; Perry, G. S.; Croft, J. B.] CDC, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
RP Wheaton, AG (reprint author), CDC, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
NR 1
TC 2
Z9 2
U1 1
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAY 18
PY 2011
VL 305
IS 19
BP 1956
EP 1958
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 764WO
UT WOS:000290665500011
ER
PT J
AU Rakhmanina, N
Hader, S
Denson, A
Gaur, A
Mitchell, C
Henderson, S
Paul, M
Barton, T
Herbert-Grant, M
Perez, E
Malachowski, J
Dominguez, K
Danner, S
Nesheim, S
Ivy, W
Iuliano, D
AF Rakhmanina, N.
Hader, S.
Denson, A.
Gaur, A.
Mitchell, C.
Henderson, S.
Paul, M.
Barton, T.
Herbert-Grant, M.
Perez, E.
Malachowski, J.
Dominguez, K.
Danner, S.
Nesheim, S.
Ivy, W.
Iuliano, D.
TI Premastication of Food by Caregivers of HIV-Exposed Children-Nine U.S.
Sites, 2009-2010 (Reprinted from MMWR, vol 60, pg 273-275, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
ID INFECTION; INFANTS
C1 [Rakhmanina, N.] Childrens Natl Med Ctr, Washington, DC 20010 USA.
[Hader, S.; Denson, A.] Dept Hlth, Washington, DC USA.
[Gaur, A.] St Jude Childrens Hosp, Memphis, TN 38105 USA.
[Mitchell, C.] Univ Miami, Miller Sch Med, Coral Gables, FL 33124 USA.
[Henderson, S.] Emory Univ, Atlanta, GA 30322 USA.
[Paul, M.] Texas Childrens Hosp, Baylor Coll Med, Houston, TX 77030 USA.
[Barton, T.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
[Herbert-Grant, M.] Univ Hosp, New Jersey Med Sch, Newark, NJ USA.
[Perez, E.] Univ Puerto Rico, San Juan, PR 00936 USA.
[Malachowski, J.] Tulane Univ, Sch Publ Hlth, New Orleans, LA 70118 USA.
[Dominguez, K.; Danner, S.; Nesheim, S.] Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div HIV AIDS Prevent, Atlanta, GA USA.
[Ivy, W.; Iuliano, D.] CDC, Atlanta, GA 30333 USA.
RP Rakhmanina, N (reprint author), Childrens Natl Med Ctr, Washington, DC 20010 USA.
NR 10
TC 0
Z9 0
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAY 18
PY 2011
VL 305
IS 19
BP 1958
EP 1962
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 764WO
UT WOS:000290665500012
ER
PT J
AU Wilkie, M
McGivern, T
Skeels, M
DeBess, E
Progulske, BA
Cieslak, PR
Brouillard, K
Gage, KL
Griffith, K
Petersen, JM
Tourdjman, M
AF Wilkie, M.
McGivern, T.
Skeels, M.
DeBess, E.
Progulske, B. A.
Cieslak, P. R.
Brouillard, K.
Gage, K. L.
Griffith, K.
Petersen, J. M.
Tourdjman, M.
TI Notes from the Field: Two Cases of Human Plague-Oregon, 2010 (Reprinted
from MMWR, vol 60, pg 214, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Wilkie, M.] Lake Cty Publ Hlth Dept, Lakeview, OR 97630 USA.
[McGivern, T.; Skeels, M.] Oregon State Publ Hlth Lab, Hillsboro, OR USA.
[Brouillard, K.] Spokane Reg Hlth Dist Publ Hlth Lab, Spokane, WA USA.
[Tourdjman, M.] CDC, Atlanta, GA 30333 USA.
RP Wilkie, M (reprint author), Lake Cty Publ Hlth Dept, Lakeview, OR 97630 USA.
NR 4
TC 0
Z9 0
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAY 18
PY 2011
VL 305
IS 19
BP 1962
EP 1962
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 764WO
UT WOS:000290665500013
ER
PT J
AU Miller, BL
Kretsinger, K
Euler, GL
Lu, PJ
Ahmed, F
AF Miller, Brady L.
Kretsinger, Katrina
Euler, Gary L.
Lu, Peng-Jun
Ahmed, Faruque
TI Barriers to early uptake of tetanus, diphtheria and acellular pertussis
vaccine (Tdap) among adults-United States, 2005-2007
SO VACCINE
LA English
DT Article
DE Immunization; Vaccine; Adult; Pertussis; Tdap
ID HEALTH-CARE WORKERS; IMMUNIZATION PRACTICES; NOSOCOMIAL PERTUSSIS;
ADVISORY-COMMITTEE; YOUNG INFANTS; ADOLESCENTS; INFLUENZA; COSTS;
STRATEGIES; KNOWLEDGE
AB Background: The tetanus, diphtheria and acellular pertussis vaccine (Tdap) was recommended by the Advisory Committee on Immunization Practices (ACIP) for U.S. adults in 2005. Our objective was to identify barriers to early uptake of Tdap among adult populations.
Methods: The 2007 National Immunization Survey (NIS)-Adult was a telephone survey sponsored by the Centers for Disease Control and Prevention (CDC). Immunization information was collected for persons aged >= 18 years on all ACIP-recommended vaccines. A weighted analysis accounted for the complex survey design and non-response.
Results: Overall, 3.6% of adults aged 18-64 years reported receipt of a Tdap vaccination. Of unvaccinated respondents, 18.8% had heard of Tdap, of which 9.4% reported that a healthcare provider had recommended it. A low perceived risk of contracting pertussis was the single most common reason for either not vaccinating with Tdap or being unwilling to do so (44.7%). Most unvaccinated respondents (81.8%) indicated a willingness to receive Tdap if it was recommended by a provider.
Conclusions: During the first two years of availability, Tdap uptake was likely inhibited by a low collective awareness of Tdap and a low perceived risk of contracting pertussis among U.S. adults, as well as a paucity of provider-to-patient vaccination recommendations. Significant potential exists for improved coverage, as many adults were receptive to vaccination. Published by Elsevier Ltd.
C1 [Miller, Brady L.; Euler, Gary L.; Lu, Peng-Jun; Ahmed, Faruque] Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Kretsinger, Katrina] Ctr Dis Control & Prevent, Global Immunizat Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Miller, BL (reprint author), Ctr Dis Control & Prevent, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,MS E-52, Atlanta, GA 30333 USA.
EM ion2@cdc.gov
FU US Centers for Disease Control and Prevention
FX Contributions: Mr. Miller had full access to all of the data in the
study and takes responsibility for the integrity of the data and
accuracy of the data analysis. All authors have approved the final
manuscript. Miller, Kretsinger, Euler, Lu, and Ahmed contributed to
study concept and design. Euler and Lu helped in the acquisition of the
data and Miller and Ahmed in the analysis and interpretation of the
data. Drafting of the manuscript was done by Miller and Statistical
analysis by Miller and Ahmed. Ahmed and Euler supervised the study and
along with Kretsinger and Lu lent administrative, technical or material
support. All of them helped in critical revision of the manuscript.
Financial disclosures: None reported. Conflict of interest: None
reported. Funding/support: This work was funded by the US Centers for
Disease Control and Prevention. Role of the sponsor: The findings and
conclusions in this report are those of the authors and do not
necessarily represent the views of the funding agency.
NR 50
TC 30
Z9 30
U1 1
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD MAY 17
PY 2011
VL 29
IS 22
BP 3850
EP 3856
DI 10.1016/j.vaccine.2011.03.058
PG 7
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 774FP
UT WOS:000291370900008
PM 21459173
ER
PT J
AU Gustin, KM
Belser, JA
Wadford, DA
Pearce, MB
Katz, JM
Tumpey, TM
Maines, TR
AF Gustin, Kortney M.
Belser, Jessica A.
Wadford, Debra A.
Pearce, Melissa B.
Katz, Jacqueline M.
Tumpey, Terrence M.
Maines, Taronna R.
TI Influenza virus aerosol exposure and analytical system for ferrets
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
ID H5N1 VIRUSES; TRANSMISSION MODEL; EXHALED BREATH; GUINEA-PIG; INFECTION;
PATHOGENESIS; HUMANS; MICE; INHALATION; OUTBREAK
AB Understanding the transmission ability of newly emerging influenza viruses is central to the development of public health preparedness and prevention strategies. Animals are used to model influenza virus infection and transmission, but the routinely used intranasal inoculation of a liquid virus suspension does not reflect natural infection. We report the development of an inoculation method that delivers an influenza virus aerosol inoculum to ferrets and the characterization of size distribution and viable virus present in aerosols shed from infected ferrets during normal breathing and sneezing. By comparing virus deposition, infectivity, virulence, and transmissibility among animals inoculated intranasally or by aerosols with a human (H3N2) or avian (H5N1) influenza virus, we demonstrate that aerosol inoculations more closely resemble a natural, airborne influenza virus infection and that viable virus is measurable in droplets and droplet nuclei exhaled by infected ferrets. These methods will provide improved risk assessment of emerging influenza viruses that pose a threat to public health.
C1 [Gustin, Kortney M.; Belser, Jessica A.; Wadford, Debra A.; Pearce, Melissa B.; Katz, Jacqueline M.; Tumpey, Terrence M.; Maines, Taronna R.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Maines, TR (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
EM TMaines@cdc.gov
RI Wei, Jianjian/F-7788-2011
OI Wei, Jianjian/0000-0001-8859-8462
FU Oak Ridge Institute for Science and Education
FX The authors thank Vic Veguilla for statistical expertise, Justin
Hartings for technical review of the manuscript, and the Centers for
Disease Control Animal Resources Branch for exceptional animal care. K.
Gustin is supported by Oak Ridge Institute for Science and Education.
NR 30
TC 52
Z9 54
U1 1
U2 9
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 17
PY 2011
VL 108
IS 20
BP 8432
EP 8437
DI 10.1073/pnas.1100768108
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 765OZ
UT WOS:000290719600070
PM 21536880
ER
PT J
AU Colacino, JA
Soliman, AS
Calafat, AM
Nahar, MS
Van Zomeren-Dohm, A
Hablas, A
Seifeldin, IA
Rozek, LS
Dolinoy, DC
AF Colacino, Justin A.
Soliman, Amr S.
Calafat, Antonia M.
Nahar, Muna S.
Van Zomeren-Dohm, Adrienne
Hablas, Ahmed
Seifeldin, Ibrahim A.
Rozek, Laura S.
Dolinoy, Dana C.
TI Exposure to phthalates among premenstrual girls from rural and urban
Gharbiah, Egypt: A pilot exposure assessment study
SO ENVIRONMENTAL HEALTH
LA English
DT Article
ID PREGNANT-WOMEN; URINARY LEVELS; PVC GLOVES; METABOLITES; POPULATION;
PRODUCTS; QUALITY; RATS
AB Background: Phthalates have been identified as endocrine active compounds associated with developmental and reproductive toxicity. The exposure to phthalates in premenstrual Egyptian females remains unknown. The objective of this study was to characterize phthalate exposure of a potentially vulnerable population of premenstrual girls from urban and rural Egypt.
Materials and methods: We collected one spot urine sample from 60 10-13 year old females, 30 from rural Egypt, and 30 from urban Egypt from July to October 2009. Samples were analyzed for 11 phthalate metabolites. Additionally, we collected anthropometrics as well as questionnaire data concerning food storage behaviors, cooking practices, and cosmetic use. Phthalate metabolite concentrations were compared between urban and rural Egyptians as well as to age and gender matched Americans.
Results: Monoethyl phthalate (MEP), was detected at the highest concentration in urine of Egyptian girls (median: 43.2 ng/mL in rural, 98.8 ng/mL in urban). Concentrations of urinary metabolites of di-(2-ethylhexyl) phthalate and dibutyl phthalate were comparable between Egyptians and age matched US girls. Storage of food in plastic containers was a statistically significant predictor of urinary mono-isobutyl phthalate (MiBP) concentrations when comparing covariate adjusted means.
Conclusions: Urinary concentrations of phthalate metabolites were similar in Egyptian and US populations, suggesting that phthalate exposure also occurs in developing nations. Dietary intake is likely an important route of exposure to phthalates in both urban and rural populations.
C1 [Colacino, Justin A.; Nahar, Muna S.; Van Zomeren-Dohm, Adrienne; Rozek, Laura S.; Dolinoy, Dana C.] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
[Colacino, Justin A.; Soliman, Amr S.] Univ Michigan, Ctr Global Hlth, Ann Arbor, MI 48109 USA.
[Soliman, Amr S.] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
[Calafat, Antonia M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Hablas, Ahmed; Seifeldin, Ibrahim A.] Tanta Canc Ctr, Gharbiah, Egypt.
[Hablas, Ahmed; Seifeldin, Ibrahim A.] Gharbiah Canc Soc, Gharbiah, Egypt.
RP Dolinoy, DC (reprint author), Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
EM ddolinoy@umich.edu
FU University of Michigan NIEHS P30 Core Center [P30 ES017885]; NIH
[ES017524]; National Institute of Environmental Health Sciences (NIEHS),
NIH [T32 ES07062]; University of Michigan Cancer [R25 CA112383]
FX This work was supported the University of Michigan NIEHS P30 Core Center
(P30 ES017885), with generous support from the UM School of Public
Health (SPH) and the SPH Department of Environmental Health Sciences.
Support for DCD and LSR was provided by NIH grant ES017524. Support for
JAC and MN was provided by an Institutional Training Grant from the
National Institute of Environmental Health Sciences (NIEHS), NIH (T32
ES07062) and the University of Michigan Cancer Epidemiology Education in
Special Populations Program (R25 CA112383). We acknowledge Manori Silva,
Ella Samandar, and Jim Preau for measuring the urinary concentrations of
phthalate metabolites and Stacy Endres at NIEHS for her effort in part
of the data collection.
NR 30
TC 14
Z9 14
U1 1
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-069X
J9 ENVIRON HEALTH-GLOB
JI Environ. Health
PD MAY 16
PY 2011
VL 10
AR 40
DI 10.1186/1476-069X-10-40
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 776SZ
UT WOS:000291559500001
PM 21575223
ER
PT J
AU Oster, AM
Wiegand, RE
Sionean, C
Miles, IJ
Thomas, PE
Melendez-Morales, L
Le, BC
Millett, GA
AF Oster, Alexandra M.
Wiegand, Ryan E.
Sionean, Catlainn
Miles, Isa J.
Thomas, Peter E.
Melendez-Morales, Lehida
Le, Binh C.
Millett, Gregorio A.
TI Understanding disparities in HIV infection between black and white MSM
in the United States
SO AIDS
LA English
DT Article
DE blacks/African-Americans; HIV risk; HIV/AIDS; homosexual; MSM;
race/ethnicity; United States
ID BEHAVIORAL SURVEILLANCE SYSTEM; AFRICAN-AMERICAN MEN; YOUNG MEN; RISK
BEHAVIORS; MALE CIRCUMCISION; NATIONAL-HEALTH; LOS-ANGELES; SEX;
PREVALENCE; PREVENTION
AB Objective: We evaluated several hypotheses for disparities in HIV infection between black and white MSM in the United States, including incarceration, partner HIV status, circumcision, sexual networks, and duration of infectiousness.
Design: The 2008 National HIV Behavioral Surveillance System (NHBS), a cross-sectional survey conducted in 21 US cities.
Methods: MSM were interviewed and tested for HIV infection. For MSM not previously diagnosed with HIV infection, we used logistic regression to test associations between newly diagnosed HIV infection and incarceration history, partner HIV status, circumcision status, and sexual networks (older partners, concurrency, and partner risk behaviors). For HIV-infected MSM, we assessed factors related to duration of infectiousness.
Results: Among 5183 MSM not previously diagnosed with HIV infection, incarceration history, circumcision status, and sexual networks were not independently associated with HIV infection. Having HIV-infected partners [adjusted odds ratio (AOR) = 1.9, 95% confidence interval (CI) = 1.2-3.0] or partners of unknown status (AOR = 1.4, CI = 1.1-1.7) were associated with HIV infection. Of these two factors, only one was more common among black MSM - having partners of unknown HIV status. Among previously diagnosed HIV-positive MSM, black MSM were less likely to be on anti-retroviral therapy (ART).
Conclusion: Less knowledge of partner HIV status and lower ART use among black MSM may partially explain differences in HIV infection between black and white MSM. Efforts to encourage discussions about HIV status between MSM and their partners and decrease barriers to ART provision among black MSM may decrease transmission. (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
C1 [Oster, Alexandra M.; Wiegand, Ryan E.; Sionean, Catlainn; Miles, Isa J.; Thomas, Peter E.; Melendez-Morales, Lehida; Le, Binh C.; Millett, Gregorio A.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA.
[Le, Binh C.] Northrop Grumman Inc, Atlanta, GA USA.
RP Oster, AM (reprint author), 1600 Clifton Rd NE,MS E-46, Atlanta, GA 30333 USA.
EM AOster@cdc.gov
FU Centers for Disease Control and Prevention
FX The National HIV Behavioral Surveillance System is funded by the Centers
for Disease Control and Prevention.
NR 33
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0269-9370
J9 AIDS
JI Aids
PD MAY 15
PY 2011
VL 25
IS 8
BP 1103
EP 1112
DI 10.1097/QAD.0b013e3283471efa
PG 10
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA 758FB
UT WOS:000290145800010
PM 21505305
ER
PT J
AU Breen, N
Gentleman, JF
Schiller, JS
AF Breen, Nancy
Gentleman, Jane F.
Schiller, Jeannine S.
TI Update on Mammography Trends Comparisons of Rates in 2000, 2005, and
2008
SO CANCER
LA English
DT Article
DE cancer screening; mammography; early detection of breast cancer; Healthy
People objective; National Health Interview Survey
ID SERVICES TASK-FORCE; BREAST-CANCER; SCREENING MAMMOGRAPHY;
HORMONE-THERAPY; WOMEN; BENEFITS; 40S; AGE
AB BACKGROUND: Mammography screening allows for the early detection of breast cancer, which helps reduce mortality from breast cancer, especially in women aged 50 to 69 years. For this report, the authors updated a previous analysis of trends in mammography using newly available data from the National Health Interview Survey (NHIS). METHODS: NHIS data from 2008 were used to update trends in rates of US women who had a mammogram within the 2 years before their interview, and 2 methods of calculating rates were compared. The authors focused particularly on the 2000, 2005, and 2008 mammography rates for women aged >= 40 years, 40 to 49 years, 50 to 64 years, and >= 65 years according to selected sociodemographic and healthcare access characteristics. RESULTS: For women aged 50 to 64 years and >= 65 years, the patterns were similar: Rates rose rapidly from 1987 to 2000, declined, or were stable and then declined, from 2000 to 2005, and increased from 2005 to 2008. Rates for women aged 40 to 49 years rose rapidly from 1987 to 1992 and were relatively stable through 2008. There were large increases in mammography rates among immigrants who had been in the United States for < 10 years, non-Hispanic Asian women, and women aged >= 65 years who were without ambulatory care insurance. CONCLUSIONS: Overall, mammography rates did not continue to decline between 2005 and 2008. Even so, in 2008, the percentage of women aged >= 40 years who had a recent mammogram fell below the Healthy People 2010 objective of 70%, which was met in 2000. However, women aged 50 to 64 years exceeded the Healthy People objective in 2000, 2005, and 2008; and some groups with very low mammography rates currently are catching up. These are important public health achievements. Cancer 2011; 117: 2209-18. (C) 2010 American Cancer Society.
C1 [Breen, Nancy] NCI, Hlth Serv, Rockville, MD USA.
[Breen, Nancy] NCI, Econ Branch, Appl Res Program, Div Canc Control & Populat Studies,NIH, Rockville, MD USA.
[Gentleman, Jane F.; Schiller, Jeannine S.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Div Hlth Interview Stat, Hyattsville, MD 20782 USA.
RP Breen, N (reprint author), Execut Plaza N,Suite 4500,6130 Execut Blvd,MSC 73, Rockville, MD 20850 USA.
EM breenn@mail.nih.gov
FU Intramural NIH HHS [Z99 CA999999]
NR 26
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U1 1
U2 5
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0008-543X
J9 CANCER-AM CANCER SOC
JI Cancer
PD MAY 15
PY 2011
VL 117
IS 10
BP 2209
EP 2218
DI 10.1002/cncr.25679
PG 10
WC Oncology
SC Oncology
GA 758JQ
UT WOS:000290161100024
PM 21523735
ER
PT J
AU Birlea, M
Arendt, G
Orhan, E
Schmid, DS
Bellini, WJ
Schmidt, C
Gilden, D
Cohrs, RJ
AF Birlea, Marius
Arendt, Gabriele
Orhan, Eser
Schmid, D. Scott
Bellini, William J.
Schmidt, Christian
Gilden, Don
Cohrs, Randall J.
TI Subclinical reactivation of varicella zoster virus in all stages of HIV
infection
SO JOURNAL OF THE NEUROLOGICAL SCIENCES
LA English
DT Article
DE VZV; HIV; Subclinical reactivation; CSF; Intrathecal synthesis
ID VZV IGG ANTIBODY; HERPES-ZOSTER; CEREBROSPINAL-FLUID;
MULTIPLE-SCLEROSIS; SINE HERPETE; CSF; COMPLICATIONS; BRAIN
AB Analysis of 200 paired serum and cerebrospinal fluid (CSF) samples from 180 HIV-positive individuals, 136 of whom had AIDS, revealed intrathecal synthesis of antibodies specific for varicella zoster virus (VZV) in 28 (16%) individuals, measles virus in 15 (8%), herpes simplex virus-1 (HSV-1) in 1 (0.6%), and HSV-2 in none. Of the 28 subjects with a positive VZV antibody specificity index, only 1 had zoster rash at the time of serum and CSF sampling; of the total 180 HIV-positive subjects, 146(81%) had no history of zoster. Based on an estimated 33.4 million HIV-positive individuals worldwide, subclinical reactivation of VZV in even less than 16% of HIV-positive people suggests the possibility that millions of people have active VZV infection of the central nervous system. In cases of VZV vasculopathy, myelopathy and even zoster sine herpete, the CSF is often positive for anti-VZV antibody, but negative for VZV DNA. To rule out VZV infection of the nervous system, CSF must be tested for VZV DNA and anti-VZV IgG and IgM antibody. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Birlea, Marius; Gilden, Don; Cohrs, Randall J.] Univ Colorado, Sch Med, Dept Neurol, Aurora, CO 80045 USA.
[Arendt, Gabriele; Orhan, Eser; Schmidt, Christian] Univ Dusseldorf, Dept Neurol, Fac Med, D-4000 Dusseldorf, Germany.
[Schmid, D. Scott; Bellini, William J.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Gilden, Don] Univ Colorado, Sch Med, Dept Microbiol, Aurora, CO 80045 USA.
RP Gilden, D (reprint author), Univ Colorado, Sch Med, Dept Neurol, Mail Stop B182,12700 E 19th Ave, Aurora, CO 80045 USA.
EM don.gilden@ucdenver.edu
FU National Institutes of Health [AG006127, AG032958]
FX This work was supported in part by Public Health Service grants AG006127
and AG032958 from the National Institutes of Health. The authors thank
Marina Hoffman for editorial review and Cathy Allen for manuscript
preparation.
NR 24
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U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-510X
J9 J NEUROL SCI
JI J. Neurol. Sci.
PD MAY 15
PY 2011
VL 304
IS 1-2
BP 22
EP 24
DI 10.1016/j.jns.2011.02.030
PG 3
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 757GD
UT WOS:000290072600004
PM 21419427
ER
PT J
AU Beall, BW
Gertz, RE
Hulkower, RL
Whitney, CG
Moore, MR
Brueggemann, AB
AF Beall, Bernard W.
Gertz, Robert E.
Hulkower, Rachel L.
Whitney, Cynthia G.
Moore, Matthew R.
Brueggemann, Angela B.
TI Shifting Genetic Structure of Invasive Serotype 19A Pneumococci in the
United States
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID RESISTANT STREPTOCOCCUS-PNEUMONIAE; 7-VALENT CONJUGATE VACCINE; BINDING
PROTEIN GENES; MOLECULAR EPIDEMIOLOGY; HORIZONTAL TRANSFER; CHILDREN;
CLONES; EMERGENCE; CARRIAGE; IDENTIFICATION
AB Background. Following 7-valent conjugate vaccine introduction in the United States in 2000, invasive serotype (sero19A) pneumococcal disease (IPD) emerged rapidly. Sero19A IPD incidence increased slightly during 2005-2008 (from 2.3 cases to 2.5 cases per 100,000 population), whereas sero19A penicillin resistance (defined as a minimum inhibitor concentration [MIC] >= 2 mu g/mL) increased significantly (from 28.7% to 43.7%). To better understand changes, we characterized sero19A isolates recovered during 2004-2008.
Methods. We performed antimicrobial susceptibility testing on all 2767 sero19A IPD isolates identified through the Centers for Disease Control Active Bacterial Core surveillance during 2004-2008. We genotyped 1804 (96.3%) of 1874 sero19A isolates recovered during 2005-2007 and all 148 year 2008 sero19A isolates from children < 5 years of age.
Results. Resistant clonal complex (CC) 320/271(19A) increased from 20.9% (115 of 550) to 32.9% (208 of 633; P < .001) of IPD isolates during 2005-2007, which paralleled increased sero19A penicillin resistance (from 28.7% [163 of 567 isolates] to 39.5% [261 of 661 isolates]; P < .001). Total IPD due to 320/271(19A) increased during 2005-2007 and increased from 2.1 to 3.6 cases per 100,000 population during 2005-2008 in children < 5 years of age. The penicillin-susceptible/intermediate, putative vaccine-escape CC695(19A) increased from 7.5% (41 of 550) to 13.6% (85 of 633) of sero19A isolates during 2005-2007 (P = .002).
Conclusions. Sero19A rates may have plateaued; however, clonal shifts are increasing resistance. Increased IPD caused by CC320/271(19A) and CC695(19A) could reflect additional selective advantages in addition to resistance.
C1 [Beall, Bernard W.; Gertz, Robert E.; Hulkower, Rachel L.; Whitney, Cynthia G.; Moore, Matthew R.] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA USA.
[Brueggemann, Angela B.] Univ Oxford, Dept Zool, Oxford OX1 2JD, England.
RP Beall, BW (reprint author), 1600 Clifton Rd,Mailstop C02, Atlanta, GA 30333 USA.
EM bbeall@cdc.gov
OI Brueggemann, Angela/0000-0002-2329-1934
FU CDC; CDC Antimicrobial Working Group; National Vaccine Program Office
FX This project was funded by the CDC's Emerging Infections Program, the
CDC Antimicrobial Working Group, and the National Vaccine Program
Office.
NR 32
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U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD MAY 15
PY 2011
VL 203
IS 10
BP 1360
EP 1368
DI 10.1093/infdis/jir052
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 754FC
UT WOS:000289838800003
PM 21398395
ER
PT J
AU Hamilton, KW
Abt, PL
Rosenbach, MA
Bleicher, MB
Levine, MS
Mehta, J
Montgomery, SP
Hasz, RD
Bono, BR
Tetzlaff, MT
Mildiner-Early, S
Introcaso, CE
Blumberg, EA
AF Hamilton, Keith W.
Abt, Peter L.
Rosenbach, Misha A.
Bleicher, Melissa B.
Levine, Marc S.
Mehta, Jimish
Montgomery, Susan P.
Hasz, Richard D.
Bono, Bartholomew R.
Tetzlaff, Michael T.
Mildiner-Early, Shirly
Introcaso, Camille E.
Blumberg, Emily A.
TI Donor-Derived Strongyloides stercoralis Infections in Renal Transplant
Recipients
SO TRANSPLANTATION
LA English
DT Article
DE Strongyloidiasis; Hyperinfection syndrome; Donor-derived infection;
Renal transplant; Steroid preconditioning
ID HYPERINFECTION SYNDROME; KIDNEY-TRANSPLANT; PARENTERAL IVERMECTIN;
ALLOGRAFT; TRANSMISSION; FAILURE; PATIENT; TRIAL
AB Background. Donor-derived Strongyloides stercoralis infection occurs rarely after transplantation, and the risk factors are not well understood. We present cases of two renal allograft recipients who developed Strongyloides hyperinfection syndrome after receipt of organs from a common deceased donor who received high-dose steroids as part of a preconditioning regimen.
Methods. The two renal transplant patients who developed Strongyloides hyperinfection syndrome are reported in case study format with review of the literature.
Results. Microscopic examination of stool from one renal transplant patient and of tracheal and gastric aspirates from the other transplant patient revealed evidence of S. stercoralis larvae. Retrospective testing of serum from the deceased donor for Strongyloides antibodies by enzyme-linked immunosorbent assay was positive at 11.7 U/mL (Centers for Disease Control reference >1.7 U/mL positive). One patient was treated successfully with oral ivermectin. The other patient also had complete resolution of strongyloidiasis, but required a course of parenteral ivermectin because of malabsorption from severe gastrointestinal strongyloidiasis.
Conclusions. These case studies provide some of the best evidence of transmission of S. stercoralis by renal transplantation. Because of the high risk of hyperinfection syndrome and its associated morbidity and mortality, high-risk donors and recipients should be screened for Strongyloides infection, so that appropriate treatment can be initiated before the development of disease. This study indicates that parenteral ivermectin can be used safely and effectively in patients in whom severe malabsorption would preclude the effective use of oral formulation. These cases also suggest that reconsideration should be given for the safety of steroids in donor-preconditioning regimens.
C1 [Hamilton, Keith W.; Blumberg, Emily A.] Hosp Univ Penn, Dept Med, Div Infect Dis, Philadelphia, PA 19104 USA.
[Abt, Peter L.] Hosp Univ Penn, Dept Transplant Surg, Philadelphia, PA 19104 USA.
[Rosenbach, Misha A.; Introcaso, Camille E.] Hosp Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA.
[Bleicher, Melissa B.] Hosp Univ Penn, Dept Med, Div Renal Electrolyte & Hypertens, Philadelphia, PA 19104 USA.
[Levine, Marc S.] Hosp Univ Penn, Dept Radiol, Gastrointestinal Div, Philadelphia, PA 19104 USA.
[Mehta, Jimish] Hosp Univ Penn, Dept Pharm, Philadelphia, PA 19104 USA.
[Montgomery, Susan P.] CDC, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA.
[Hasz, Richard D.] Gift Life Donor Program, Philadelphia, PA USA.
[Bono, Bartholomew R.] Albert Einstein Healthcare Syst, Dept Infect Dis, Philadelphia, PA USA.
[Tetzlaff, Michael T.] Hosp Univ Penn, Dept Pathol, Philadelphia, PA 19104 USA.
[Mildiner-Early, Shirly] Hosp Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA.
RP Hamilton, KW (reprint author), Hosp Univ Penn, Dept Med, Div Infect Dis, 3400 Spruce St,3 Silverstein Bldg, Philadelphia, PA 19104 USA.
EM Keith.hamilton@uphs.upenn.edu
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TC 29
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U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0041-1337
J9 TRANSPLANTATION
JI Transplantation
PD MAY 15
PY 2011
VL 91
IS 9
BP 1019
EP 1024
DI 10.1097/TP.0b013e3182115b7b
PG 6
WC Immunology; Surgery; Transplantation
SC Immunology; Surgery; Transplantation
GA 753KT
UT WOS:000289773000016
PM 21358367
ER
PT J
AU Flenady, V
Middleton, P
Smith, GC
Duke, W
Erwich, JJ
Khong, TY
Neilson, J
Ezzati, M
Koopmans, L
Ellwood, D
Fretts, R
Froen, JF
AF Flenady, Vicki
Middleton, Philippa
Smith, Gordon C.
Duke, Wes
Erwich, Jan Jaap
Khong, T. Yee
Neilson, Jim
Ezzati, Majid
Koopmans, Laura
Ellwood, David
Fretts, Ruth
Froen, J. Frederik
CA Lancet's Stillbirths Series Steeri
TI Stillbirths 5 Stillbirths: the way forward in high-income countries
SO LANCET
LA English
DT Article
ID RANDOMIZED-CONTROLLED-TRIAL; POPULATION-BASED COHORT;
PERINATAL-MORTALITY; UNITED-STATES; FETAL-DEATH; GESTATIONAL-AGE;
PERIODONTAL-DISEASE; ALCOHOL-CONSUMPTION; NORTHERN-IRELAND; NEONATAL
DEATHS
AB Stillbirth rates in high-income countries declined dramatically from about 1940, but this decline has slowed or stalled over recent times. The present variation in stillbirth rates across and within high-income countries indicates that further reduction in stillbirth is possible. Large disparities (linked to disadvantage such as poverty) in stillbirth rates need to be addressed by providing more educational opportunities and improving living conditions for women. Placental pathologies and infection associated with preterm birth are linked to a substantial proportion of stillbirths. The proportion of unexplained stillbirths associated with under investigation continues to impede efforts in stillbirth prevention. Overweight, obesity, and smoking are important modifiable risk factors for stillbirth, and advanced maternal age is also an increasingly prevalent risk factor. Intensified efforts are needed to ameliorate the effects of these factors on stillbirth rates. Culturally appropriate preconception care and quality antenatal care that is accessible to all women has the potential to reduce stillbirth rates in high-income countries. Implementation of national perinatal mortality audit programmes aimed at improving the quality of care could substantially reduce stillbirths. Better data on numbers and causes of stillbirth are needed, and international consensus on definition and classification related to stillbirth is a priority. All parents should be offered a thorough investigation including a high-quality autopsy and placental histopathology. Parent organisations are powerful change agents and could have an important role in raising awareness to prevent stillbirth. Future research must focus on screening and interventions to reduce antepartum stillbirth as a result of placental dysfunction. Identification of ways to reduce maternal overweight and obesity is a high priority for high-income countries.
C1 [Flenady, Vicki] Mater Med Res Inst, Mater Hlth Serv, Brisbane, Qld 4101, Australia.
[Flenady, Vicki] Univ Queensland, Brisbane, Qld, Australia.
[Flenady, Vicki] Int Stillbirth Alliance, Baltimore, MD USA.
[Middleton, Philippa] Univ Adelaide, Adelaide, SA, Australia.
[Smith, Gordon C.] Univ Cambridge, Dept Obstet & Gynaecol, Cambridge, England.
[Duke, Wes] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Erwich, Jan Jaap] Univ Groningen, Dept Obstet, Utrecht, Netherlands.
[Erwich, Jan Jaap] Fdn Perinatal Audit Netherlands, Utrecht, Netherlands.
[Khong, T. Yee] Womens & Childrens Hosp, SA Pathol, Adelaide, SA, Australia.
[Neilson, Jim] Univ Liverpool, Cochrane Pregnancy & Childbirth Grp, Liverpool L69 3BX, Merseyside, England.
[Ezzati, Majid] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC HPA Ctr Environm & Hlth, London, England.
[Ellwood, David] Canberra Hosp, Canberra, ACT, Australia.
[Ellwood, David] Australian Natl Univ, Sch Med, Canberra, ACT, Australia.
[Fretts, Ruth] Harvard Vanguard Med Associates, Wellesley, MA USA.
[Froen, J. Frederik] Norwegian Inst Publ Hlth, Div Epidemiol, Oslo, Norway.
RP Flenady, V (reprint author), Mater Med Res Inst, Mater Hlth Serv, Brisbane, Qld 4101, Australia.
EM Vicki.Flenady@mmri.mater.org.au
RI Froen, J. Frederik/C-3271-2009; Smith, Gordon/A-8070-2008; Flenady,
Vicki/O-9609-2014;
OI Smith, Gordon/0000-0003-2124-0997; Froen Froen, Jahn
Frederik/0000-0001-9390-8509
FU Bill & Melinda Gates Foundation; International Stillbirth Alliance;
Norwegian Institute of Public Health
FX We thank the Bill & Melinda Gates Foundation for a grant to support this
work to the International Stillbirth Alliance administered by the Mater
Medical Research Institute, Brisbane, QLD, Australia. Additionally, we
thank the International Stillbirth Alliance and the Norwegian Institute
of Public Health for seed funding to support meetings of the steering
committee. We thank the following for technical support: Dominique
Rossouw, Madeleine Elder, and, Elizabeth Flenady for literature
searching and reference management, Kristen Gibbons for statistical
advice, and Glenda Hawley, Teresa Walsh, Shelley Wilkinson, and Ann
Kingsbury for providing feedback on the report. We thank Janet Scott of
Sands UK, Sue Hale of Sands UK and ISA Parent Advisory Committee, and
Liz Conway Sands Australia and the ISA Parent Advisory Committee for
their comments and contributions to the report. We thank the following
for their contributions to the research priority component: Justus
Hofmeyr for his assistance with the development of the research priority
questions, review of interventions, and comment of drafts of the report;
Eckhart Buchmann for development of the initial drafts of all the
research questions; Igor Rudan for guidance and support; and Ibinabo
Ibiebele for data analysis. We thank all those who scored the stillbirth
research priorities: Adrian Charles, Paul Colditz, Linda Dodds, Lelia
Duley, Jason Gardosi, Sanne Gordijn, Grace Guyon, Justus Hofmeyr, Alex
Heazell, Robyn Kennare, Russell Kirby, Wolfgang Kuenzel, Kassam Mahomed,
Luigi Matturri, Elizabeth M McClure, Lesley McCowan, Giorgio Mello,
Ayman el Mohandes, Halit Pinar, Ingela Radestad, Uma M Reddy, Birgit
Reime, Bob Silver, and Bert Timmer, and members of the GAPPS Basic
Biology Working Group: Craig Rubens, Michael Gravett, Gordon Smith,
Leslie Myatt, Oslem Equils, Roger Smith, and Sarah England.
NR 156
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U1 2
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
J9 LANCET
JI Lancet
PD MAY 14
PY 2011
VL 377
IS 9778
BP 1703
EP 1717
DI 10.1016/S0140-6736(11)60064-0
PG 15
WC Medicine, General & Internal
SC General & Internal Medicine
GA 766JF
UT WOS:000290777700035
PM 21496907
ER
PT J
AU Kidd, S
Goodson, JL
Aramburu, J
Morais, A
Gaye, A
Wannemuehler, K
Buffington, J
Gerber, S
Wassilak, S
Uzicanin, A
AF Kidd, Sarah
Goodson, James L.
Aramburu, Javier
Morais, Alda
Gaye, Abou
Wannemuehler, Kathleen
Buffington, Joanna
Gerber, Sue
Wassilak, Steven
Uzicanin, Amra
TI Poliomyelitis outbreaks in Angola genetically linked to India: Risk
factors and implications for prevention of outbreaks due to wild
poliovirus importations
SO VACCINE
LA English
DT Article
DE Poliomyelitis; Vaccination; Angola
ID VACCINE
AB We conducted an investigation of two outbreaks of poliomyelitis in Angola during 2007-2008 due to wild poliovirus (WPV) genetically linked to India. A case-control study including 27 case-patients and 76 age- and neighborhood-matched control-subjects was conducted to assess risk factors associated with paralytic poliomyelitis, and epidemiologic links to India were explored through in-depth case-patient interviews. In multivariable analysis, case-patients were more likely than control-subjects to be undervaccinated with fewer than four routine doses of oral poliovirus vaccine (adjusted matched odds ratio [aMOR], 4.1; 95% confidence interval [CI], 1.2-13.6) and have an adult household member who traveled outside the province of residence in the 2 months preceding onset of paralysis (aMOR, 3.2; 95% CI, 1.2-8.6). No epidemiologic link with India was identified. These findings underscore the importance of routine immunization to prevent outbreaks following WPV importations and suggest a possible role of adults in sustaining WPV transmission. Published by Elsevier Ltd.
C1 [Kidd, Sarah] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA.
[Kidd, Sarah; Goodson, James L.; Wannemuehler, Kathleen; Buffington, Joanna; Gerber, Sue; Wassilak, Steven; Uzicanin, Amra] Ctr Dis Control & Prevent, Global Immunizat Div, Atlanta, GA 30333 USA.
[Aramburu, Javier; Gaye, Abou] World Hlth Org, Expanded Program Immunizat, Burundi, Angola.
[Morais, Alda] Minist Hlth, Expanded Program Immunizat, Luanda, Angola.
RP Kidd, S (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, 1600 Clifton Rd NE,MS E04, Atlanta, GA 30333 USA.
EM hgk9@cdc.gov
FU Angola Ministry of Health; World Health Organization (WHO); United
States Centers for Disease Control and Prevention (CDC)
FX This work was supported by the Angola Ministry of Health; World Health
Organization (WHO); and the United States Centers for Disease Control
and Prevention (CDC). The findings and conclusions in this report are
those of the authors and do not necessarily represent the official
position of the CDC. The authors would like to thank Dr. Jorge Mariscal,
the CORE group, the WHO surveillance officers, and the many colleagues
at the Angola Ministry of Health, WHO, and CDC who supported and
contributed to this investigation.
NR 21
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U1 1
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD MAY 12
PY 2011
VL 29
IS 21
BP 3760
EP 3766
DI 10.1016/j.vaccine.2011.03.034
PG 7
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 770FN
UT WOS:000291072500011
PM 21440639
ER
PT J
AU Eko, FO
Okenu, DN
Singh, UP
He, Q
Black, C
Igietseme, JU
AF Eko, F. O.
Okenu, D. N.
Singh, U. P.
He, Q.
Black, C.
Igietseme, J. U.
TI Evaluation of a broadly protective Chlamydia-cholera combination vaccine
candidate
SO VACCINE
LA English
DT Article
DE Chlamydia; Cross-protection; Combination vaccine; Cholera
ID OBLIGATE INTRACELLULAR PATHOGEN; OUTER-MEMBRANE PROTEIN; HIGH-RISK
WOMEN; VIBRIO-CHOLERAE; GENITAL-TRACT; IMMUNE-RESPONSE; ENDOCERVICAL
SPECIMENS; TRACHOMATIS SEROVARS; FIELD TRIAL; T-CELLS
AB The need to simultaneously target infections with epidemiological overlap in the population with a single vaccine provides the basis for developing combination vaccines. Vibrio cholerae ghosts (rVCG) offer an attractive approach for developing vaccines against a number of human and animal pathogens. In this study, we constructed a multisubunit vaccine candidate co-expressing the serovar D-derived Porin B and polymorphic membrane protein-D proteins of Chlamydia trachomatis and evaluated its ability to simultaneously induce broad-based chlamydial immunity and elicit a vibriocidal antibody response to the Vibrio carrier envelope. Intramuscular (IM) immunization with the vaccine candidate elicited high levels of antigen-specific genital mucosal and systemic Th1 cell-mediated and humoral immune responses against heterologous serovars and strains, including serovars E-H and L Also, in addition to the multisubunit vaccine, the single subunit constructs conferred significant cross protection against the heterologous mouse strain, Chlamydia muridarum. Furthermore, all mice immunized with rVCG vaccine constructs responded with a significant rise in vibriocidal antibody titer, the surrogate marker for protection in cholera. These findings demonstrate the ability of the multisubunit vaccine to induce cross protective chlamydial as well as vibriocidal immunity and establish the possibility of developing a broadly efficacious Chlamydia-cholera combination vaccine. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Eko, F. O.] Morehouse Sch Med, Dept Microbiol Biochem & Immunol, Atlanta, GA 30310 USA.
[Singh, U. P.] Univ S Carolina, Sch Med, Columbia, SC USA.
[Black, C.; Igietseme, J. U.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA.
RP Eko, FO (reprint author), Morehouse Sch Med, Dept Microbiol Biochem & Immunol, 720 Westview Dr,SW, Atlanta, GA 30310 USA.
EM feko@msm.edu
FU National Institutes of Health [AI41231]; National Center for Research
Resources, National Institutes of Health [1 C06 RR18386]
FX This work was supported by a Public Health Service grant AI41231 from
the National Institutes of Health. The investigation was conducted in a
facility constructed with support from Research Facilities Improvement
Grant #1 C06 RR18386 from the National Center for Research Resources,
National Institutes of Health.
NR 56
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U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD MAY 12
PY 2011
VL 29
IS 21
BP 3802
EP 3810
DI 10.1016/j.vaccine.2011.03.027
PG 9
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 770FN
UT WOS:000291072500016
PM 21421002
ER
PT J
AU Karon, AE
Hanni, KD
Mohle-Boetani, JC
Beretti, RA
Hill, VR
Arrowood, M
Johnston, SP
Xiao, L
Vugia, DJ
AF Karon, A. E.
Hanni, K. D.
Mohle-Boetani, J. C.
Beretti, R. A.
Hill, V. R.
Arrowood, M.
Johnston, S. P.
Xiao, L.
Vugia, D. J.
TI Giardiasis outbreak at a camp after installation of a slow-sand
filtration water-treatment system
SO EPIDEMIOLOGY AND INFECTION
LA English
DT Article
DE Giardia lamblis; giardiasis; outbreaks; waterborne infections
ID CRYPTOSPORIDIUM; CYST
AB In July and August 2007, a giardiasis outbreak affected attendees of a private recreational camp in California. Twenty-six persons had laboratory-confirmed giardiasis; another 24 had giardiasis-like illness with no stool test. A retrospective cohort study determined that showering was associated with illness (adjusted odds ratio 3.1, 95% confidence interval 1.1-9.3). Two days before the outbreak began, the camp had installed a slow-sand water filtration system that included unsterilized sand. Review of historical water-quality data identified substantially elevated total coliform and turbidity levels in sand-filtered spring water used for showering during the suspected exposure period. Unfiltered spring water tested at the same time had acceptable coliform and turbidity levels, implicating the filtration system as the most likely contamination source. To prevent waterborne illness, slow-sand water filtration systems should use sterilized sand, and slow-sand-filtered water should not be used for any purpose where inadvertent ingestion could occur until testing confirms its potability.
C1 [Karon, A. E.; Mohle-Boetani, J. C.; Vugia, D. J.] Calif Dept Publ Hlth, Richmond, CA USA.
[Karon, A. E.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Off Workforce & Career Dev, Atlanta, GA USA.
[Hanni, K. D.; Beretti, R. A.] Monterey Cty Hlth Dept, Salinas, CA USA.
[Hill, V. R.; Arrowood, M.; Johnston, S. P.; Xiao, L.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vectorborne & Enter Dis, Atlanta, GA USA.
RP Karon, AE (reprint author), Bur Communicable Dis & Emergency Response, Wisconsin Div Publ Hlth, 1 W Wilson St,Room 318, Madison, WI 53701 USA.
EM aekaron@gmail.com
RI Hill, Vincent/G-1789-2012; Xiao, Lihua/B-1704-2013; Magana,
Felipe/B-6966-2013
OI Hill, Vincent/0000-0001-7069-7737; Xiao, Lihua/0000-0001-8532-2727;
NR 12
TC 6
Z9 7
U1 2
U2 12
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0950-2688
J9 EPIDEMIOL INFECT
JI Epidemiol. Infect.
PD MAY 11
PY 2011
VL 139
IS 5
BP 713
EP 717
DI 10.1017/S0950268810001573
PG 5
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 757RM
UT WOS:000290105400008
PM 20587126
ER
PT J
AU Witkop, C
Duffy, M
Cohen, L
Fishbein, D
Selent, M
AF Witkop, C.
Duffy, M.
Cohen, L.
Fishbein, D.
Selent, M.
TI Assessment of ESSENCE Performance for Influenza-Like Illness
Surveillance After an Influenza Outbreak-U.S. Air Force Academy,
Colorado, 2009 (Reprinted from MMWR, vol 60, pg 406-409, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
ID SYNDROMIC SURVEILLANCE; SYSTEM
C1 [Selent, M.] CDC, Div Global Migrat & Quarantine, Natl Ctr Emerging & Zoonot Infect Dis, EIS, Atlanta, GA 30333 USA.
[Witkop, C.] USAF Acad, Colorado Springs, CO USA.
[Duffy, M.] USAF, Sch Aerosp Med, Wright Patterson AFB, OH 45433 USA.
[Cohen, L.] CDC, Sci Educ & Profess Dev Program Off, Off Surveillance Epidemiol & Lab Svcs, Atlanta, GA 30333 USA.
RP Selent, M (reprint author), CDC, Div Global Migrat & Quarantine, Natl Ctr Emerging & Zoonot Infect Dis, EIS, Atlanta, GA 30333 USA.
EM mselent@cdc.gov
NR 11
TC 0
Z9 0
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAY 11
PY 2011
VL 305
IS 18
BP 1851
EP 1853
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 761YH
UT WOS:000290438800010
ER
PT J
AU Pratt, R
Price, S
Miramontes, R
Navin, T
Abraham, BK
AF Pratt, R.
Price, S.
Miramontes, R.
Navin, T.
Abraham, B. K.
TI Trends in Tuberculosis-United States, 2010 (Reprinted from MMWR, vol 60,
pg 333-337, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
C1 [Pratt, R.; Price, S.; Miramontes, R.; Navin, T.] CDC, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
[Abraham, B. K.] CDC, EIS, Atlanta, GA 30333 USA.
RP Pratt, R (reprint author), CDC, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
NR 1
TC 1
Z9 1
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAY 11
PY 2011
VL 305
IS 18
BP 1853
EP 1855
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 761YH
UT WOS:000290438800011
ER
PT J
AU Khamsiriwatchara, A
Wangroongsarb, P
Thwing, J
Eliades, J
Satimai, W
Delacollette, C
Kaewkungwal, J
AF Khamsiriwatchara, Amnat
Wangroongsarb, Piyaporn
Thwing, Julie
Eliades, James
Satimai, Wichai
Delacollette, Charles
Kaewkungwal, Jaranit
TI Respondent-driven sampling on the Thailand-Cambodia border. I. Can
malaria cases be contained in mobile migrant workers?
SO MALARIA JOURNAL
LA English
DT Article
ID PLASMODIUM-FALCIPARUM; HIDDEN POPULATIONS; SURVEILLANCE; CHALLENGES
AB Background: Reliable information on mobility patterns of migrants is a crucial part of the strategy to contain the spread of artemisinin-resistant malaria parasites in South-East Asia, and may also be helpful to efforts to address other public health problems for migrants and members of host communities. In order to limit the spread of malarial drug resistance, the malaria prevention and control programme will need to devise strategies to reach cross-border and mobile migrant populations.
Methodology: The Respondent-driven sampling (RDS) method was used to survey migrant workers from Cambodia and Myanmar, both registered and undocumented, in three Thai provinces on the Thailand-Cambodia border in close proximity to areas with documented artemisinin-resistant malaria parasites. 1,719 participants (828 Cambodian and 891 Myanmar migrants) were recruited. Subpopulations of migrant workers were analysed using the Thailand Ministry of Health classification based on length of residence in Thailand of greater than six months (long-term, or M1) or less than six months (short-term, or M2). Key information collected on the structured questionnaire included patterns of mobility and migration, demographic characteristics, treatment-seeking behaviours, and knowledge, perceptions, and practices about malaria.
Results: Workers from Cambodia came from provinces across Cambodia, and 22% of Cambodian M1 and 72% of Cambodian M2 migrants had been in Cambodia in the last three months. Less than 6% returned with a frequency of greater than once per month. Of migrants from Cambodia, 32% of M1 and 68% of M2 were planning to return, and named provinces across Cambodia as their likely next destinations. Most workers from Myanmar came from Mon state (86%), had never returned to Myanmar (85%), and only 4% stated plans to return.
Conclusion: Information on migratory patterns of migrants from Myanmar and Cambodia along the malaria endemic Thailand-Cambodian border within the artemisinin resistance containment zone will help target health interventions, including treatment follow-up and surveillance.
C1 [Eliades, James; Delacollette, Charles] Mahidol Univ, Fac Trop Med, WHO, Mekong Malaria Programme, Bangkok 10400, Thailand.
[Khamsiriwatchara, Amnat; Kaewkungwal, Jaranit] Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok, Thailand.
[Wangroongsarb, Piyaporn; Satimai, Wichai] Minist Publ Hlth, Bur Vector Borne Dis, Bangkok, Thailand.
[Thwing, Julie] CDC, Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Delacollette, C (reprint author), Mahidol Univ, Fac Trop Med, WHO, Mekong Malaria Programme, 420-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM delacollettec@searo.who.int
FU Bill & Melinda Gates Foundation [48821.01]
FX Authors wish to acknowledge the financial contribution from the Bill &
Melinda Gates Foundation (Grant-48821.01).
NR 23
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U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD MAY 10
PY 2011
VL 10
AR 120
DI 10.1186/1475-2875-10-120
PG 11
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 780IY
UT WOS:000291850500001
PM 21554744
ER
PT J
AU Wheaton, AG
Perry, GS
Chapman, DP
McKnight-Eily, LR
Presley-Cantrell, LR
Croft, JB
AF Wheaton, Anne G.
Perry, Geraldine S.
Chapman, Daniel P.
McKnight-Eily, Lela R.
Presley-Cantrell, Letitia R.
Croft, Janet B.
TI Relationship between body mass index and perceived insufficient sleep
among US adults: an analysis of 2008 BRFSS data
SO BMC PUBLIC HEALTH
LA English
DT Article
ID CORONARY-HEART-DISEASE; SELF-REPORTED SLEEP; FOLLOW-UP; METABOLIC
FUNCTION; UNITED-STATES; WEIGHT CHANGE; RISK-FACTORS; DURATION; OBESITY;
POPULATION
AB Background: Over the past 50 years, the average sleep duration for adults in the United States has decreased while the prevalence of obesity and associated outcomes has increased. The objective of this study was to determine whether perceived insufficient sleep was associated with body mass index (BMI) in a national sample.
Methods: We analyzed data from the 2008 Behavioral Risk Factor Surveillance System (BRFSS) survey (N = 384,541) in which respondents were asked, "During the past 30 days, for about how many days have you felt you did not get enough rest or sleep?" We divided respondents into six BMI categories and used multivariable linear regression and logistic regression analyses to assess the association between BMI categories and days of insufficient sleep after adjusting for sociodemographic variables, smoking, physical activity, and frequent mental distress.
Results: Adjusted mean days of insufficient sleep ranged from 7.9 (95% confidence interval [CI]: 7.8, 8.0) days for people of normal weight to 10.5 (95% CI: 10.2, 10.9) days for those in the highest weight category (BMI >= 40). Days of perceived insufficient sleep followed a linear trend across BMI categories. The likelihood of reporting >= 14 days of insufficient sleep in the previous 30 days was higher for respondents in the highest weight category than for those who were normal weight (34.9% vs. 25.2%; adjusted odds ratio = 1.7 (95% CI: 1.5, 1.8]).
Conclusion: Among U. S. adults, days of insufficient rest or sleep strongly correlated with BMI. Sleep sufficiency should be an important consideration in the assessment of the health of overweight and obese people and should be considered by developers of weight-reduction programs.
C1 [Wheaton, Anne G.; Perry, Geraldine S.; Chapman, Daniel P.; McKnight-Eily, Lela R.; Presley-Cantrell, Letitia R.; Croft, Janet B.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30041 USA.
RP Wheaton, AG (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mailstop K-67, Atlanta, GA 30041 USA.
EM AWheaton@cdc.gov
FU Association for Prevention Teaching and Research (APTR); Centers for
Disease Control and Prevention (CDC) [3U50CD300860]
FX This publication/project was made possible through a cooperative
agreement between the Association for Prevention Teaching and Research
(APTR) and the Centers for Disease Control and Prevention (CDC), award
number 3U50CD300860; its contents are the responsibility of the authors
and do not necessarily reflect the official position of APTR or CDC.
Disclaimer: The findings and conclusions in this report are those of the
authors and do not necessarily represent the official position of the
Centers for Disease Control and Prevention.
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PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAY 10
PY 2011
VL 11
AR 295
DI 10.1186/1471-2458-11-295
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 767IZ
UT WOS:000290851100001
PM 21569264
ER
PT J
AU Maines, TR
Chen, LM
Belser, JA
Van Hoeven, N
Smith, E
Donis, RO
Tumpey, TM
Katz, JM
AF Maines, Taronna R.
Chen, Li-Mei
Belser, Jessica A.
Van Hoeven, Neal
Smith, Elizabeth
Donis, Ruben O.
Tumpey, Terrence M.
Katz, Jacqueline M.
TI Multiple genes contribute to the virulent phenotype observed in ferrets
of an H5N1 influenza virus isolated from Thailand in 2004
SO VIROLOGY
LA English
DT Article
DE Avian influenza; Pathogenesis; H5N1 virus; Ferret; Virulence
determinants
ID LOWER RESPIRATORY-TRACT; A H5N1; NEURAMINIDASE; INFECTION; HUMANS;
PATHOGENESIS; MAMMALS; HOST; MICE
AB Human infections with highly pathogenic H5N1 avian influenza viruses continue to occur in many parts of the world and pose a considerable public health threat. With the use of animal models, the identification of virulence determinants has been instrumental in improving our understanding of how these viruses cause severe disease in humans. Two genetically similar H5N1 viruses (A/Thailand/16/2004 and A(Thailand/SP83/2004) exhibit high or low virulence phenotypes, respectively, in multiple animal models. Reassortant viruses were generated from this virus pair and evaluated in ferrets. Each of the polymerase genes of A/Thailand/16/2004 virus individually conferred increased virulence to A/Thailand/SP83/2004 virus while the neuraminidase of the low virulence virus reduced virulence and replication efficiency of the virulent virus in ferrets unless the homologous HA was present. Our results demonstrate that H5N1 virus virulence determinants are polygenic and that there is an important correlation between polymerase adaptation, efficient replication in the host, and virulence. Published by Elsevier Inc.
C1 [Maines, Taronna R.; Chen, Li-Mei; Belser, Jessica A.; Van Hoeven, Neal; Smith, Elizabeth; Donis, Ruben O.; Tumpey, Terrence M.; Katz, Jacqueline M.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Katz, JM (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS-G16, Atlanta, GA 30333 USA.
EM jkatz@cdc.gov
NR 34
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U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0042-6822
J9 VIROLOGY
JI Virology
PD MAY 10
PY 2011
VL 413
IS 2
BP 226
EP 230
DI 10.1016/j.virol.2011.02.005
PG 5
WC Virology
SC Virology
GA 757CS
UT WOS:000290062400009
PM 21388650
ER
PT J
AU Zhang, XY
Lu, H
Holt, JB
AF Zhang, Xingyou
Lu, Hua
Holt, James B.
TI Modeling spatial accessibility to parks: a national study
SO INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS
LA English
DT Article
ID CHOICE SET DEFINITION; PHYSICAL-ACTIVITY; DESTINATION CHOICE; MINUS 2;
ENVIRONMENTAL JUSTICE; INTEGRATED APPROACH; BUILT ENVIRONMENT; US
ADULTS; NUMBER 7; HEALTH
AB Background: Parks provide ideal open spaces for leisure-time physical activity and important venues to promote physical activity. The spatial configuration of parks, the number of parks and their spatial distribution across neighborhood areas or local regions, represents the basic park access potential for their residential populations. A new measure of spatial access to parks, population-weighted distance (PWD) to parks, combines the advantages of current park access approaches and incorporates the information processing theory and probability access surface model to more accurately quantify residential population's potential spatial access to parks.
Results: The PWD was constructed at the basic level of US census geography - blocks - using US park and population data. This new measure of population park accessibility was aggregated to census tract, county, state and national levels. On average, US residential populations are expected to travel 6.7 miles to access their local neighborhood parks. There are significant differences in the PWD to local parks among states. The District of Columbia and Connecticut have the best access to local neighborhood parks with PWD of 0.6 miles and 1.8 miles, respectively. Alaska, Montana, and Wyoming have the largest PWDs of 62.0, 37.4, and 32.8 miles, respectively. Rural states in the western and Midwestern US have lower neighborhood park access, while urban states have relatively higher park access.
Conclusions: The PWD to parks provides a consistent platform for evaluating spatial equity of park access and linking with population health outcomes. It could be an informative evaluation tool for health professionals and policy makers. This new method could be applied to quantify geographic accessibility of other types of services or destinations, such as food, alcohol, and tobacco outlets.
C1 [Zhang, Xingyou; Lu, Hua; Holt, James B.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA.
RP Zhang, XY (reprint author), Ctr Dis Control & Prevent CDC, Atlanta, GA USA.
EM gyx8@cdc.gov
FU NCI NIH HHS [R01 CA140319]
NR 53
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U2 53
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-072X
J9 INT J HEALTH GEOGR
JI Int. J. Health Geogr.
PD MAY 9
PY 2011
VL 10
AR 31
DI 10.1186/1476-072X-10-31
PG 14
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 779WD
UT WOS:000291812000001
PM 21554690
ER
PT J
AU Wangroongsarb, P
Satimai, W
Khamsiriwatchara, A
Thwing, J
Eliades, JM
Kaewkungwal, J
Delacollette, C
AF Wangroongsarb, Piyaporn
Satimai, Wichai
Khamsiriwatchara, Amnat
Thwing, Julie
Eliades, James M.
Kaewkungwal, Jaranit
Delacollette, Charles
TI Respondent-driven sampling on the Thailand-Cambodia border. II.
Knowledge, perception, practice and treatment-seeking behaviour of
migrants in malaria endemic zones
SO MALARIA JOURNAL
LA English
DT Article
ID PLASMODIUM-FALCIPARUM; POPULATIONS
AB Background: Population movements along the Thailand-Cambodia border, particularly among highly mobile and hard-to-access migrant groups from Cambodia and Myanmar, are assumed to play a key role in the spread of artemisinin resistance. Data on treatment-seeking behaviours, knowledge and perceptions about malaria, and use of preventive measures is lacking as characteristics of this population prevent them from being represented in routine surveillance and the lack of a sampling frame makes reliable surveys challenging.
Methods: A survey of migrant populations from Cambodia and Myanmar was implemented in five selected rural locations in Thailand along the Thai-Cambodian border using respondent driven sampling (RDS) to determine demographic characteristics of the population, migratory patterns, knowledge about malaria, and health-care -seeking behaviours.
Results: The majority of migrants from Myanmar are long-term residents (98%) with no plans to move back to Myanmar, understand spoken Thai (77%) and can therefore benefit from health messages in Thai, have Thai health insurance (99%) and accessed public health services in Thailand (63%) for their last illness. In comparison, the majority of Cambodian migrants are short-term (72%). Of the short-term Cambodian migrants, 92% work in agriculture, 18% speak Thai, 3.4% have Thai health insurance, and the majority returned to Cambodia for treatment (45%), self-treated (11%), or did not seek treatment for their last illness (27%).
Conclusion: Most highly mobile migrants along the Thai-Cambodia border are not accessing health messages or health treatment in Thailand, increasing their risk of malaria and facilitating the spread of potentially resistant Plasmodium falciparum as they return to Cambodia to seek treatment. Reaching out to highly mobile migrants with health messaging they can understand and malaria diagnosis and treatment services they can access is imperative in the effort to contain the spread of artemisinin-resistant P. falciparum.
C1 [Eliades, James M.; Delacollette, Charles] Mahidol Univ, Fac Trop Med, Mekong Malaria Programme, World Hlth Org, Bangkok 10400, Thailand.
[Wangroongsarb, Piyaporn; Satimai, Wichai] Minist Publ Hlth, Bureau Vector Borne Dis, Bangkok, Thailand.
[Khamsiriwatchara, Amnat; Kaewkungwal, Jaranit] Ctr Excellence Biomed & Publ Hlth Informat BIOPHI, Bangkok, Thailand.
[Thwing, Julie] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Delacollette, C (reprint author), Mahidol Univ, Fac Trop Med, Mekong Malaria Programme, World Hlth Org, 420-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM delacollettec@searo.who.int
FU Bill & Melinda Gates Foundation [48821.01]
FX Authors wish to acknowledge the financial contribution from the Bill &
Melinda Gates Foundation (Grant-48821.01) to conduct the survey.
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD MAY 9
PY 2011
VL 10
AR 117
DI 10.1186/1475-2875-10-117
PG 12
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 780IX
UT WOS:000291850300001
PM 21554711
ER
PT J
AU Samandari, T
Agizew, TB
Nyirenda, S
Tedla, Z
Sibanda, T
Shang, N
Mosimaneotsile, B
Motsamai, OI
Bozeman, L
Davis, MK
Talbot, EA
Moeti, TL
Moffat, H
Kilmarx, PH
Castro, KG
Wells, CD
AF Samandari, Taraz
Agizew, Tefera B.
Nyirenda, Samba
Tedla, Zegabriel
Sibanda, Thabisa
Shang, Nong
Mosimaneotsile, Barudi
Motsamai, Oaitse I.
Bozeman, Lorna
Davis, Margarett K.
Talbot, Elizabeth A.
Moeti, Themba L.
Moffat, Howard
Kilmarx, Peter H.
Castro, Kenneth G.
Wells, Charles D.
TI 6-month versus 36-month isoniazid preventive treatment for tuberculosis
in adults with HIV infection in Botswana: a randomised, double-blind,
placebo-controlled trial
SO LANCET
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; LATENT
TUBERCULOSIS; SOUTH-AFRICA; MYCOBACTERIUM-TUBERCULOSIS; 3 REGIMENS;
COHORT; RISK; PROGRAM; IMPACT
AB Background In accordance with WHO guidelines, people with HIV infection in Botswana receive daily isoniazid preventive therapy against tuberculosis without obtaining a tuberculin skin test, but duration of prophylaxis is restricted to 6 months. We aimed to assess effectiveness of extended isoniazid therapy.
Methods In our randomised, double-blind, placebo-controlled trial we enrolled adults infected with HIV aged 18 years or older at government HIV-care clinics in Botswana. Exclusion criteria included current illness such as cough and an abnormal chest radiograph without antecedent tuberculosis or pneumonia. Eligible individuals were randomly allocated (1:1) to receive 6 months' open-label isoniazid followed by 30 months' masked placebo (control group) or 6 months' open-label isoniazid followed by 30 months' masked isoniazid (continued isoniazid group) on the basis of a computer-generated randomisation list with permuted blocks of ten at each clinic. Antiretroviral therapy was provided if participants had CD4-positive lymphocyte counts of fewer than 200 cells per mu L. We used Cox regression analysis and the log-rank test to compare incident tuberculosis in the groups. Cox regression models were used to estimate the effect of antiretroviral therapy. The trial is registered at ClinicalTrials.gov, number NCT00164281.
Findings Between Nov 26, 2004, and July 3, 2009, we recorded 34 (3.4%) cases of incident tuberculosis in 989 participants allocated to the control group and 20 (2.0%) in 1006 allocated to the continued isoniazid group (incidence 1.26% per year vs 0.72%; hazard ratio 0.57, 95% CI 0.33-0.99, p=0.047). Tuberculosis incidence in those individuals receiving placebo escalated approximately 200 days after completion of open-label isoniazid. Participants who were tuberculin skin test positive (ie, >= 5 mm induration) at enrolment received a substantial benefit from continued isoniazid treatment (0.26, 0.09-0.80, p=0.02), whereas participants who were tuberculin skin test-negative received no significant benefit (0 75, 0.38-1.46, p=0.40). By study completion, 946 (47%) of 1995 participants had initiated antiretroviral therapy. Tuberculosis incidence was reduced by 50% in those receiving 360 days of antiretroviral therapy compared with participants receiving no antiretroviral therapy (adjusted hazard ratio 0.50, 95% CI 0.26-0.97). Severe adverse events and death were much the same in the control and continued isoniazid groups.
Interpretation In a tuberculosis-endemic setting, 36 months' isoniazid prophylaxis was more effective for prevention of tuberculosis than was 6-month prophylaxis in individuals with HIV infection, and chiefly benefited those who were tuberculin skin test positive.
C1 [Samandari, Taraz; Agizew, Tefera B.; Nyirenda, Samba; Tedla, Zegabriel; Sibanda, Thabisa; Mosimaneotsile, Barudi; Davis, Margarett K.; Talbot, Elizabeth A.] Botswana USA Partnership BOTUSA, Gaborone, Botswana.
[Samandari, Taraz; Agizew, Tefera B.; Nyirenda, Samba; Tedla, Zegabriel; Sibanda, Thabisa; Mosimaneotsile, Barudi; Davis, Margarett K.; Talbot, Elizabeth A.] Botswana USA Partnership BOTUSA, Francistown, Botswana.
[Motsamai, Oaitse I.] Minist Hlth, Natl TB Programme, Gaborone, Botswana.
[Samandari, Taraz; Shang, Nong; Bozeman, Lorna; Talbot, Elizabeth A.; Castro, Kenneth G.; Wells, Charles D.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA.
[Kilmarx, Peter H.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA.
RP Samandari, T (reprint author), 1600 Clifton Rd NE,Mailstop E-45, Atlanta, GA 30333 USA.
EM tts0@cdc.gov
OI Kilmarx, Peter/0000-0001-6464-3345
FU US Centers for Disease Control and Prevention; US Agency for
International Development
FX Funding US Centers for Disease Control and Prevention and US Agency for
International Development.
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PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
J9 LANCET
JI Lancet
PD MAY 7
PY 2011
VL 377
IS 9777
BP 1588
EP 1598
DI 10.1016/S0140-6736(11)60204-3
PG 11
WC Medicine, General & Internal
SC General & Internal Medicine
GA 763IJ
UT WOS:000290549700032
PM 21492926
ER
PT J
AU Thomas, JD
Hatcher, CP
Satterfield, DA
Theodore, MJ
Bach, MC
Linscott, KB
Zhao, X
Wang, X
Mair, R
Schmink, S
Arnold, KE
Stephens, DS
Harrison, LH
Hollick, RA
Andrade, AL
Lamaro-Cardoso, J
de Lemos, APS
Gritzfeld, J
Gordon, S
Soysal, A
Bakir, M
Sharma, D
Jain, S
Satola, SW
Messonnier, NE
Mayer, LW
AF Thomas, Jennifer Dolan
Hatcher, Cynthia P.
Satterfield, Dara A.
Theodore, M. Jordan
Bach, Michelle C.
Linscott, Kristin B.
Zhao, Xin
Wang, Xin
Mair, Raydel
Schmink, Susanna
Arnold, Kathryn E.
Stephens, David S.
Harrison, Lee H.
Hollick, Rosemary A.
Andrade, Ana Lucia
Lamaro-Cardoso, Juliana
de Lemos, Ana Paula S.
Gritzfeld, Jenna
Gordon, Stephen
Soysal, Ahmet
Bakir, Mustafa
Sharma, Dolly
Jain, Shabnam
Satola, Sarah W.
Messonnier, Nancy E.
Mayer, Leonard W.
TI sodC-Based Real-Time PCR for Detection of Neisseria meningitidis
SO PLOS ONE
LA English
DT Article
ID SUPEROXIDE-DISMUTASE; STREPTOCOCCUS-PNEUMONIAE; BACTERIAL-MENINGITIS;
CEREBROSPINAL-FLUID; MENINGOCOCCAL CARRIAGE; HAEMOPHILUS-INFLUENZAE;
IDENTIFICATION; SEQUENCE; DIAGNOSIS; GENES
AB Real-time PCR (rt-PCR) is a widely used molecular method for detection of Neisseria meningitidis (Nm). Several rt-PCR assays for Nm target the capsule transport gene, ctrA. However, over 16% of meningococcal carriage isolates lack ctrA, rendering this target gene ineffective at identification of this sub-population of meningococcal isolates. The Cu-Zn superoxide dismutase gene, sodC, is found in Nm but not in other Neisseria species. To better identify Nm, regardless of capsule genotype or expression status, a sodC-based TaqMan rt-PCR assay was developed and validated. Standard curves revealed an average lower limit of detection of 73 genomes per reaction at cycle threshold (C(t)) value of 35, with 100% average reaction efficiency and an average R(2) of 0.9925. 99.7% (624/626) of Nm isolates tested were sodC-positive, with a range of average C(t) values from 13.0 to 29.5. The mean sodC C(t) value of these Nm isolates was 17.6 +/- 2.2 (+/- SD). Of the 626 Nm tested, 178 were nongroupable (NG) ctrA-negative Nm isolates, and 98.9% (176/178) of these were detected by sodC rt-PCR. The assay was 100% specific, with all 244 non-Nm isolates testing negative. Of 157 clinical specimens tested, sodC detected 25/157 Nm or 4 additional specimens compared to ctrA and 24 more than culture. Among 582 carriage specimens, sodC detected Nm in 1 more than ctrA and in 4 more than culture. This sodC rt-PCR assay is a highly sensitive and specific method for detection of Nm, especially in carriage studies where many meningococcal isolates lack capsule genes.
C1 [Thomas, Jennifer Dolan; Hatcher, Cynthia P.; Satterfield, Dara A.; Theodore, M. Jordan; Bach, Michelle C.; Linscott, Kristin B.; Zhao, Xin; Wang, Xin; Mair, Raydel; Schmink, Susanna; Messonnier, Nancy E.; Mayer, Leonard W.] Ctr Dis Control & Prevent, Meningitis & Vaccine Preventable Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Arnold, Kathryn E.] Georgia Dept Community Hlth, Div Publ Hlth, Atlanta, GA USA.
[Stephens, David S.; Sharma, Dolly; Jain, Shabnam; Satola, Sarah W.] Emory Univ, Sch Med, Atlanta, GA USA.
[Arnold, Kathryn E.; Stephens, David S.; Satola, Sarah W.] Georgia Emerging Infect Program, Atlanta, GA USA.
[Stephens, David S.; Satola, Sarah W.] Vet Affairs Med Ctr, Atlanta, GA 30033 USA.
[Sharma, Dolly; Jain, Shabnam] Childrens Healthcare Atlanta, Atlanta, GA USA.
[Satterfield, Dara A.; Bach, Michelle C.] Agnes Scott Coll, Dept Biol, Decatur, GA 30030 USA.
[Harrison, Lee H.; Hollick, Rosemary A.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Andrade, Ana Lucia; Lamaro-Cardoso, Juliana] Univ Fed Goias, Inst Patol Trop & Saude Publ, Goiania, Go, Brazil.
[de Lemos, Ana Paula S.] Inst Adolfo Lutz Registro, Sao Paulo, Brazil.
[Gritzfeld, Jenna; Gordon, Stephen] Univ Liverpool, Liverpool Sch Trop Med, Clin Grp, Liverpool L3 5QA, Merseyside, England.
[Soysal, Ahmet; Bakir, Mustafa] Marmara Univ, Sch Med, Div Pediat Infect Dis, Istanbul, Turkey.
RP Thomas, JD (reprint author), Ctr Dis Control & Prevent, Meningitis & Vaccine Preventable Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
EM fsu8@cdc.gov
RI Stephens, David/A-8788-2012; Iats, Inct/K-2300-2013; Andrade, Ana
Lucia/L-5751-2013;
OI Gordon, Stephen/0000-0001-6576-1116
FU Brazilian National Council for Scientific and Technological Development
(CNPq) [309196/2007-8]; National Institute of Science and Technology for
Health Technology Assessment/IATS; National Institutes of Health
[5D43TW006592]
FX ALA was supported by the Brazilian National Council for Scientific and
Technological Development (CNPq grant # 309196/2007-8)
(http://www.cnpq.br/english/cnpq/index.htm) and was supported by the
National Institute of Science and Technology for Health Technology
Assessment/IATS (http://www.iats.com.br/eng/instituto.php?id_cms_menu =
1). APS de Lemos was supported by the Fogarty International Center
Global Infectious Diseases Research Training Program grant from the
National Institutes of Health (5D43TW006592) (http://www.fic.nih.gov/).
JG and SG thank the NIHR Biomedical Research Centre in Microbial
Diseases (http://www.rlbuht.nhs.uk/NIHR_BRC/Introduction.asp) and the
Northwest Regional Development Agency (http://www.nwda.co.uk/) for
infrastructural support. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 45
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 5
PY 2011
VL 6
IS 5
AR e19361
DI 10.1371/journal.pone.0019361
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 759OB
UT WOS:000290256400007
ER
PT J
AU Satterwhite, CL
Gottlieb, SL
Romaguera, R
Bolan, G
Burstein, G
Schuler, C
Popovic, T
AF Satterwhite, C. L.
Gottlieb, S. L.
Romaguera, R.
Bolan, G.
Burstein, G.
Schuler, C.
Popovic, T.
TI CDC Grand Rounds: Chlamydia Prevention: Challenges and Strategies for
Reducing Disease Burden and Sequelae (Reprinted from MMWR, vol 60, pg
370-373, 2011)
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Reprint
ID SEXUALLY-TRANSMITTED-DISEASES; PELVIC-INFLAMMATORY-DISEASE;
UNITED-STATES; WOMEN; TRACHOMATIS; INFECTION
C1 [Popovic, T.] CDC, Off Director, Atlanta, GA 30333 USA.
[Satterwhite, C. L.; Gottlieb, S. L.; Romaguera, R.] CDC, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
[Burstein, G.] SUNY Buffalo, Dept Pediat, Buffalo, NY 14260 USA.
[Burstein, G.] Women & Childrens Hosp Buffalo, Buffalo, NY USA.
RP Popovic, T (reprint author), CDC, Off Director, Atlanta, GA 30333 USA.
EM tpopovic@cdc.gov
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U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA
SN 0098-7484
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD MAY 4
PY 2011
VL 305
IS 17
BP 1757
EP 1759
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 758HZ
UT WOS:000290156200009
ER
PT J
AU Switzer, WM
Jia, HW
Zheng, HQ
Tang, SH
Heneine, W
AF Switzer, William M.
Jia, Hongwei
Zheng, HaoQiang
Tang, Shaohua
Heneine, Walid
TI No Association of Xenotropic Murine Leukemia Virus-Related Viruses with
Prostate Cancer
SO PLOS ONE
LA English
DT Article
ID CHRONIC-FATIGUE-SYNDROME; XMRV INFECTION; BLOOD-DONORS; GENE-THERAPY;
RETROVIRUS; CONTAMINATION; SEQUENCES; ASSAY; ANTIBODIES; MULTIPLE
AB Background: The association of the xenotropic murine leukemia virus-related virus (XMRV) with prostate cancer continues to receive heightened attention as studies report discrepant XMRV prevalences ranging from zero up to 23%. It is unclear if differences in the diagnostic testing, disease severity, geography, or other factors account for the discordant results. We report here the prevalence of XMRV in a population with well-defined prostate cancers and RNase L polymorphism. We used broadly reactive PCR and Western blot (WB) assays to detect infection with XMRV and related murine leukemia viruses (MLV).
Methodology/Principal Findings: We studied specimens from 162 US patients diagnosed with prostate cancer with a intermediate to advanced stage (Gleason Scores of 5-10; moderate (46%) poorly differentiated tumors (54%)). Prostate tissue DNA was tested by PCR assays that detect XMRV and MLV variants. To exclude contamination with mouse DNA, we also designed and used a mouse-specific DNA PCR test. Detailed phylogenetic analysis was used to infer evolutionary relationships. RNase L typing showed that 9.3% were homozygous (QQ) for the R462Q RNase L mutation, while 45.6% and 45.1% were homozygous or heterozygous, respectively. Serologic testing was performed by a WB test. Three of 162 (1.9%) prostate tissue DNA were PCR-positive for XMRV and had undetectable mouse DNA. None was homozygous for the QQ mutation. Plasma from all three persons was negative for viral RNA by RT-PCR. All 162 patients were WB negative. Phylogenetic analysis inferred a distinct XMRV.
Conclusions and Their Significance: We found a very low prevalence of XMRV in prostate cancer patients. Infection was confirmed by phylogenetic analysis and absence of contaminating mouse DNA. The finding of undetectable antibodies and viremia in all three patients may reflect latent infection. Our results do not support an association of XMRV or MLV variants with prostate cancer.
C1 [Switzer, William M.; Jia, Hongwei; Zheng, HaoQiang; Tang, Shaohua; Heneine, Walid] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
RP Switzer, WM (reprint author), Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
EM bis3@cdc.gov
FU Centers for Disease Control and Prevention per annual appropriations of
the United States Government
FX Funding for the study was provided by the Centers for Disease Control
and Prevention per annual appropriations of the United States
Government. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 4
PY 2011
VL 6
IS 5
AR e19065
DI 10.1371/journal.pone.0019065
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 759EZ
UT WOS:000290224800015
PM 21573232
ER
PT J
AU Kaltman, JR
Thompson, PD
Lantos, J
Berul, CI
Botkin, J
Cohen, JT
Cook, NR
Corrado, D
Drezner, J
Frick, KD
Goldman, S
Hlatky, M
Kannankeril, PJ
Leslie, L
Priori, S
Saul, JP
Shapiro-Mendoza, CK
Siscovick, D
Vetter, VL
Boineau, R
Burns, KM
Friedman, RA
AF Kaltman, Jonathan R.
Thompson, Paul D.
Lantos, John
Berul, Charles I.
Botkin, Jeffrey
Cohen, Joshua T.
Cook, Nancy R.
Corrado, Domenico
Drezner, Jonathan
Frick, Kevin D.
Goldman, Stuart
Hlatky, Mark
Kannankeril, Prince J.
Leslie, Laurel
Priori, Silvia
Saul, J. Philip
Shapiro-Mendoza, Carrie K.
Siscovick, David
Vetter, Victoria L.
Boineau, Robin
Burns, Kristin M.
Friedman, Richard A.
TI Screening for Sudden Cardiac Death in the Young Report From a National
Heart, Lung, and Blood Institute Working Group
SO CIRCULATION
LA English
DT Article
DE death, sudden; pediatrics; screening
ID HYPERTROPHIC CARDIOMYOPATHY; SCIENTIFIC STATEMENT; ASSOCIATION COUNCIL;
CHILDREN; PREVENTION; ADOLESCENTS; STRATEGIES; GUIDELINES; AUTOPSY;
DISEASE
C1 [Kaltman, Jonathan R.; Boineau, Robin; Burns, Kristin M.] NHLBI, NIH, Bethesda, MD 20817 USA.
[Thompson, Paul D.] Univ Connecticut, Hartford, CT 06112 USA.
[Lantos, John] Univ Missouri, Kansas City, MO 64110 USA.
[Berul, Charles I.; Burns, Kristin M.] Childrens Natl Med Ctr, Washington, DC 20010 USA.
[Botkin, Jeffrey] Univ Utah, Salt Lake City, UT USA.
[Cohen, Joshua T.; Leslie, Laurel] Tufts Univ, Boston, MA 02111 USA.
[Corrado, Domenico] Univ Padua, Sch Med, Padua, Italy.
[Drezner, Jonathan; Siscovick, David] Univ Washington, Seattle, WA 98195 USA.
[Frick, Kevin D.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Cook, Nancy R.; Goldman, Stuart] Harvard Univ, Sch Med, Boston, MA USA.
[Hlatky, Mark] Stanford Univ, Stanford, CA 94305 USA.
[Kannankeril, Prince J.] Vanderbilt Univ, Nashville, TN USA.
[Priori, Silvia] NYU, Med Ctr, New York, NY 10016 USA.
[Saul, J. Philip] Med Univ S Carolina, Charleston, SC 29425 USA.
[Shapiro-Mendoza, Carrie K.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Vetter, Victoria L.] Univ Penn, Sch Med, Philadelphia, PA 19104 USA.
[Friedman, Richard A.] Texas Childrens Hosp, Houston, TX 77030 USA.
RP Kaltman, JR (reprint author), NHLBI, NIH, 6701 Rockledge Dr,Room 8222, Bethesda, MD 20817 USA.
EM kaltmanj@nhlbi.nih.gov
OI Friedman, Richard/0000-0003-3046-1505; Cohen, Joshua/0000-0003-1737-0991
FU National Institutes of Health research [HL100546]
FX Drs Leslie and Cohen are the recipients of a National Institutes of
Health research grant (No. HL100546).
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAY 3
PY 2011
VL 123
IS 17
BP 1911
EP 1918
DI 10.1161/CIRCULATIONAHA.110.017228
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 758GB
UT WOS:000290149300015
PM 21537007
ER
PT J
AU Patton, TG
Dietrich, G
Dolan, MC
Piesman, J
Carroll, JA
Gilmore, RD
AF Patton, Toni G.
Dietrich, Gabrielle
Dolan, Marc C.
Piesman, Joseph
Carroll, James A.
Gilmore, Robert D., Jr.
TI Functional Analysis of the Borrelia burgdorferi bba64 Gene Product in
Murine Infection via Tick Infestation
SO PLOS ONE
LA English
DT Article
ID LYME-DISEASE SPIROCHETE; OUTER SURFACE-PROTEINS; TOLL-LIKE RECEPTORS;
BORRELIA-BURGDORFERI; MAMMALIAN HOST; LINEAR PLASMID; IXODES TICKS;
LIFE-CYCLE; EXPRESSION; TRANSMISSION
AB Borrelia burgdorferi, the causative agent of Lyme borreliosis, transmitted to humans to from the bite of Ixodes spp. ticks. During the borrelial tick-to-mammal life cycle, B. burgdorferi must adapt to many environmental changes by regulating several genes, including bba64. Our laboratory recently demonstrated that the bba64 gene product is necessary for mouse infectivity when B. burgdorferi is transmitted by an infected tick bite, but not via needle inoculation. In this study we investigated the phenotypic properties of a bba64 mutant strain, including 1) replication during tick engorgement, 2) migration into the nymphal salivary glands, 3) host transmission, and 4) susceptibility to the MyD88-dependent innate immune response. Results revealed that the bba64 mutant's attenuated infectivity by tick bite was not due to a growth defect inside an actively feeding nymphal tick, or failure to invade the salivary glands. These findings suggested there was either a lack of spirochete transmission to the host dermis or increased susceptibility to the host's innate immune response. Further experiments showed the bba64 mutant was not culturable from mouse skin taken at the nymphal bite site and was unable to establish infection in MyD88-deficient mice via tick infestation. Collectively, the results of this study indicate that BBA64 functions at the salivary gland-to-host delivery interface of vector transmission and is not involved in resistance to MyD88-mediated innate immunity.
C1 [Patton, Toni G.; Dietrich, Gabrielle; Dolan, Marc C.; Piesman, Joseph; Gilmore, Robert D., Jr.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Ft Collins, CO 80521 USA.
[Carroll, James A.] NIAID, Persistent Viral Dis Lab, Rocky Mt Labs, NIH, Hamilton, MT USA.
RP Patton, TG (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Ft Collins, CO 80521 USA.
EM rbg9@cdc.gov
FU Centers for Disease Control and Prevention, a branch of the Department
of Health and Human Services within the federal government
FX This work was supported by the Centers for Disease Control and
Prevention, a branch of the Department of Health and Human Services
within the federal government. The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
NR 57
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U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 3
PY 2011
VL 6
IS 5
AR e19536
DI 10.1371/journal.pone.0019536
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 759EM
UT WOS:000290223500028
PM 21559293
ER
PT J
AU Ekwueme, DU
Uzunangelov, V
Hoerger, T
Saraiya, M
Miller, J
Hall, I
Benard, V
Royalty, J
Li, C
AF Ekwueme, D. U.
Uzunangelov, V
Hoerger, T.
Saraiya, M.
Miller, J.
Hall, I
Benard, V
Royalty, J.
Li, C.
TI ESTIMATED EFFECTS OF THE NATIONAL BREAST AND CERVICAL CANCER EARLY
DETECTION PROGRAM ON CERVICAL CANCER MORTALITY
SO VALUE IN HEALTH
LA English
DT Meeting Abstract
C1 [Ekwueme, D. U.; Saraiya, M.; Miller, J.; Hall, I; Benard, V; Royalty, J.; Li, C.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Uzunangelov, V; Hoerger, T.] RTI Int, Res Triangle Pk, NC USA.
NR 0
TC 0
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U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1098-3015
J9 VALUE HEALTH
JI Value Health
PD MAY
PY 2011
VL 14
IS 3
BP A1
EP A1
PG 1
WC Economics; Health Care Sciences & Services; Health Policy & Services
SC Business & Economics; Health Care Sciences & Services
GA 876JY
UT WOS:000299105000003
ER
PT J
AU Guh, S
Grosse, S
McAlister, S
Kessler, CM
Soucie, M
AF Guh, S.
Grosse, S.
McAlister, S.
Kessler, C. M.
Soucie, M.
TI COSTS OF CARE FOR PRIVATELY INSURED MALES WITH HEMOPHILIA IN THE UNITED
STATES, 2008
SO VALUE IN HEALTH
LA English
DT Meeting Abstract
C1 [Guh, S.; Grosse, S.; McAlister, S.; Soucie, M.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Kessler, C. M.] Georgetown Univ, Washington, DC USA.
NR 0
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U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1098-3015
J9 VALUE HEALTH
JI Value Health
PD MAY
PY 2011
VL 14
IS 3
BP A61
EP A61
PG 1
WC Economics; Health Care Sciences & Services; Health Policy & Services
SC Business & Economics; Health Care Sciences & Services
GA 876JY
UT WOS:000299105000321
ER
PT J
AU Trujillo, AJ
Vecino-Ortiz, AI
Gomez, FR
Steinhardt, LC
AF Trujillo, A. J.
Vecino-Ortiz, A., I
Ruiz Gomez, F.
Steinhardt, L. C.
TI IMPROVING HEALTH INSURANCE AND PREVENTIVE EFFORT AMONG DIABETIC
PATIENTS: THE COLOMBIAN EXPERIENCE
SO VALUE IN HEALTH
LA English
DT Meeting Abstract
C1 [Trujillo, A. J.] Johns Hopkins Sch Publ Hlth, Baltimore, MD USA.
[Vecino-Ortiz, A., I] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA.
[Ruiz Gomez, F.] Univ Javeriana, Bogota, DC, Colombia.
[Steinhardt, L. C.] Ctr Dis Control, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1098-3015
J9 VALUE HEALTH
JI Value Health
PD MAY
PY 2011
VL 14
IS 3
BP A100
EP A100
PG 1
WC Economics; Health Care Sciences & Services; Health Policy & Services
SC Business & Economics; Health Care Sciences & Services
GA 876JY
UT WOS:000299105000524
ER
PT J
AU Jean, SM
Morales, PR
Paul, K
Garcia, A
AF Jean, Sherrie M.
Morales, Pablo R.
Paul, Katherine
Garcia, AnaPatricia
TI Spontaneous Primary Squamous Cell Carcinoma of the Lung in a Rhesus
Macaque (Macaca mulatta)
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Article
ID HEALTH-ORGANIZATION CLASSIFICATION; CANCER; TUMORS; PULMONARY;
PATHOLOGY; MARKER
AB A 3-y-old male rhesus macaque (Macaca mulatta) was noticed to be lethargic in the compound. Physical exam revealed cyanotic mucous membranes, dyspnea, bilateral harsh lung sounds, wheezing on expiration, and a firm mass possibly associated with the liver. Radiographs revealed bilateral soft tissue opacities in the thorax. Due to poor prognosis, the rhesus was euthanized, and a necropsy was performed. Both right and left lung lobes were consolidated and had multifocal white tan masses. On cut section, the masses were firm, had areas of necrosis, hemorrhage, and often contained a tenacious exudate. Masses were identified in the liver and both kidneys. Given the morphologic features of the neoplasm, a diagnosis of squamous cell carcinoma was made. Immunohistochemistry staining for thyroid transcription factor, a nuclear transcription factor normally found in lung, thyroid, and tumors arising from either of those tissues, confirmed that the masses originated from the lung. Malignant primary lung tumors are divided into 8 main histologic subtypes: squamous cell carcinoma, small-cell carcinoma, large-cell carcinoma, adenocarcinoma, adenosquamous carcinoma, sarcomatoid carcinoma, carcinoid tumor, and salivary gland tumors. Clinical signs associated with lung tumors include, but are not limited to, dyspnea, coughing, hemoptysis, lethargy, anorexia, and weight loss. Although squamous cell carcinoma will be low on the differential list for these clinical signs, we encourage clinicians and researchers to not rule it out solely based on incidence and age of the animal.
C1 [Garcia, AnaPatricia] Emory Univ, Sch Med, Div Pathol, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA.
[Garcia, AnaPatricia] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA.
[Jean, Sherrie M.] Univ So Calif, Dept Anim Resources, Los Angeles, CA USA.
[Morales, Pablo R.] Mannheimer Fdn, Homestead, FL USA.
[Paul, Katherine] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Garcia, A (reprint author), Emory Univ, Sch Med, Div Pathol, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA.
EM agarci5@emory.edu
FU NIH [R25 RR024504, DRR000165, P51 RR000165]
FX This work was supported in part by NIH grants R25 RR024504, DRR000165,
and P51 RR000165.
NR 20
TC 1
Z9 1
U1 0
U2 1
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD MAY
PY 2011
VL 50
IS 3
BP 404
EP 408
PG 5
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 875JO
UT WOS:000299026400017
PM 21640039
ER
PT J
AU Spadaro, AJ
Grunbaum, JA
Dawkins, NU
Wright, DS
Rubel, SK
Green, DC
Simoes, EJ
AF Spadaro, Antonia J.
Grunbaum, Jo Anne
Dawkins, Nicola U.
Wright, Demia S.
Rubel, Stephanie K.
Green, Diane C.
Simoes, Eduardo J.
TI Training and Technical Assistance to Enhance Capacity Building Between
Prevention Research Centers and Their Partners
SO PREVENTING CHRONIC DISEASE
LA English
DT Article
ID PUBLIC-HEALTH; PARTICIPATORY RESEARCH; COMMUNITY; INITIATIVES
AB Introduction
The Centers for Disease Control and Prevention has administered the Prevention Research Centers Program since 1986. We quantified the number and reach of training programs across all centers, determined whether the centers' outcomes varied by characteristics of the academic institution, and explored potential benefits of training and technical assistance for academic researchers and community partners. We characterized how these activities enhanced capacity building within Prevention Research Centers and the community.
Methods
The program office collected quantitative information on training across all 33 centers via its Internet-based system from April through December 2007. Qualitative data were collected from April through May 2007. We selected 9 centers each for 2 separate, semistructured, telephone interviews, 1 on training and 1 on technical assistance.
Results
Across 24 centers, 4,777 people were trained in 99 training programs in fiscal year 2007 (October 1, 2006-September 30, 2007). Nearly 30% of people trained were community members or agency representatives. Training and technical assistance activities provided opportunities to enhance community partners' capacity in areas such as conducting needs assessments and writing grants and to improve the centers' capacity for cultural competency.
Conclusion
Both qualitative and quantitative data demonstrated that training and technical assistance activities can foster capacity building and provide a reciprocal venue to support researchers' and the community's research interests. Future evaluation could assess community and public health partners' perception of centers' training programs and technical assistance.
C1 [Spadaro, Antonia J.; Grunbaum, Jo Anne; Wright, Demia S.; Green, Diane C.; Simoes, Eduardo J.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
[Dawkins, Nicola U.; Rubel, Stephanie K.] ICF Macro, Atlanta, GA USA.
RP Spadaro, AJ (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,Mailstop K-45, Atlanta, GA 30341 USA.
EM aqs5@cdc.gov
FU CDC's National Center for Chronic Disease Prevention and Health
Promotion (NCCDPHP); Division of Adult and Community Health (DACH),
Community Health and Program Services Branch; Sharrice White-Cooper;
MPH; Marie Borgella, MBA, at CDC's NCCDPHP/DACH, Prevention Research
Centers Program Office
FX We acknowledge the support of Paul Z. Siegel, MD, MPH, at CDC's National
Center for Chronic Disease Prevention and Health Promotion (NCCDPHP),
Division of Adult and Community Health (DACH), Community Health and
Program Services Branch, and Sharrice White-Cooper, MPH, and Marie
Borgella, MBA, at CDC's NCCDPHP/DACH, Prevention Research Centers
Program Office.
NR 26
TC 2
Z9 2
U1 1
U2 6
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD MAY
PY 2011
VL 8
IS 3
AR A65
PG 12
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 874OR
UT WOS:000298968400016
PM 21477505
ER
PT J
AU Zohoori, N
Pulley, L
Jones, C
Senner, J
Shoob, H
Merritt, RK
AF Zohoori, Namvar
Pulley, LeaVonne
Jones, Camille
Senner, John
Shoob, Hylan
Merritt, Robert K.
TI Conducting a Statewide Health Examination Survey: The Arkansas
Cardiovascular Health Examination Survey (ARCHES)
SO PREVENTING CHRONIC DISEASE
LA English
DT Article
AB Introduction
The Arkansas Cardiovascular Health Examination Survey is a health and nutrition examination survey designed to serve as a demonstration project for collection of data on the prevalence of chronic diseases and their risk factors at the state level. The survey was conducted from mid-2006 through early 2008.
Methods
We chose a cross-sectional representative sample of adult residents in Arkansas by using a 3-stage, cluster sample design. Trained interviewers conducted interviews and examinations in respondents' homes, collecting data on risk factors and diseases, blood pressure and anthropometric measurements, and blood and urine samples for analysis and storage. Food frequency questionnaires provided dietary and nutrient intake data. We accomplished the project using a collaborative model among several programs and partners within the state.
Results
A total of 4,894 eligible households were contacted by telephone. Of these, refusals accounted for 2,748, and 2,146 gave initial consent to participate, for an initial response rate of 44%. The final number of completed household visits was 1,385, resulting in a final response rate of 28.3%.
Conclusion
The Arkansas Cardiovascular Health Examination Survey is among the first state-level health and nutrition examination surveys to be conducted in the United States. By using a collaborative model and leveraging federal funds, we engaged several partners who provided additional resources to complete the project. The survey provides the state with valuable state-level data and information for program design and delivery.
C1 [Pulley, LeaVonne] Univ Arkansas Med Sci, Fay W Boozman Coll Publ Hlth, Little Rock, AR 72205 USA.
[Jones, Camille] Arkansas Minor Hlth Commiss, Little Rock, AR USA.
[Zohoori, Namvar] Arkansas Dept Hlth, Ctr Hlth Adv, Little Rock, AR 72205 USA.
[Shoob, Hylan; Merritt, Robert K.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Zohoori, N (reprint author), Arkansas Dept Hlth, Ctr Hlth Adv, 4815 W Markham St,Slot 6, Little Rock, AR 72205 USA.
EM Namvar.Zohoori@arkansas.gov
FU CDC; Abbott Renal Care Inc; Blue and You Foundation for a Healthier
Arkansas; Arkansas Minority Health Commission; Arkansas Department of
Health
FX We thank the staff at the following institutions for their help in
various aspects of the survey: ADH, University of Arkansas for Medical
Sciences Fay W. Boozman College of Public Health, Arkansas Minority
Health Commission, Abbott Renal Care Inc, EMSI, CRL, the Survey Research
Centers of the University of Arkansas at Little Rock and at
Fayetteville, Fred Hutchinson Cancer Research Center, American Heart
Association, and Blue and You Foundation for a Healthier Arkansas.
Direct funding support for ARCHES was received from CDC, Abbott Renal
Care Inc, Blue and You Foundation for a Healthier Arkansas, Arkansas
Minority Health Commission, and the following programs at the Arkansas
Department of Health: Tobacco Prevention and Cessation Program, Diabetes
Prevention and Control Program, and the Oral Health Program.
NR 11
TC 3
Z9 3
U1 1
U2 2
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD MAY
PY 2011
VL 8
IS 3
AR A67
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 874OR
UT WOS:000298968400018
PM 21477507
ER
PT J
AU Baggs, J
Gee, J
Lewis, E
Fowler, G
Benson, P
Lieu, T
Naleway, A
Klein, NP
Baxter, R
Belongia, E
Glanz, J
Hambidge, SJ
Jacobsen, SJ
Jackson, L
Nordin, J
Weintraub, E
AF Baggs, James
Gee, Julianne
Lewis, Edwin
Fowler, Gabrielle
Benson, Patti
Lieu, Tracy
Naleway, Allison
Klein, Nicola P.
Baxter, Roger
Belongia, Edward
Glanz, Jason
Hambidge, Simon J.
Jacobsen, Steven J.
Jackson, Lisa
Nordin, Jim
Weintraub, Eric
TI The Vaccine Safety Datalink: A Model for Monitoring Immunization Safety
SO PEDIATRICS
LA English
DT Article
DE vaccine safety; immunization; Vaccine Safety Datalink; postmarketing
evaluation; surveillance
ID HEALTH MAINTENANCE ORGANIZATIONS; THIMEROSAL-CONTAINING VACCINES;
DEFENSE MEDICAL SURVEILLANCE; INACTIVATED INFLUENZA VACCINE;
UNITED-STATES; CAUSAL ASSOCIATION; ADVERSE EVENTS; DEVELOPMENTAL
DISORDERS; ACTIVE SURVEILLANCE; YOUNG-CHILDREN
AB The Vaccine Safety Datalink (VSD) project is a collaborative project between the Centers for Disease Control and Prevention and 8 managed care organizations (MCOs) in the United States. Established in 1990 to conduct postmarketing evaluations of vaccine safety, the project has created an infrastructure that allows for high-quality research and surveillance. The 8 participating MCOs comprise a large population of 8.8 million members annually (3% of the US population), which enables researchers to conduct studies that assess adverse events after immunization. Each MCO prepares computerized data files by using a standardized data dictionary containing demographic and medical information on its members, such as age and gender, health plan enrollment, vaccinations, hospitalizations, outpatient clinic visits, emergency department visits, urgent care visits, and mortality data, as well as additional birth information (eg, birth weight) when available. Other information sources, such as medical chart review, member surveys, and pharmacy, laboratory, and radiology data, are often used in VSD studies to validate outcomes and vaccination data. Since 2000, the VSD has undergone significant changes including an increase in the number of participating MCOs and enrolled population, changes in data-collection procedures, the creation of near real-time data files, and the development of near real-time postmarketing surveillance for newly licensed vaccines or changes in vaccine recommendations. Recognized as an important resource in vaccine safety, the VSD is working toward increasing transparency through data-sharing and external input. With its recent enhancements, the VSD provides scientific expertise, continues to develop innovative approaches for vaccine-safety research, and may serve as a model for other patient safety collaborative research projects. Pediatrics 2011;127:S45-S53
C1 [Baggs, James; Gee, Julianne; Fowler, Gabrielle; Weintraub, Eric] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA 30333 USA.
[Lewis, Edwin; Klein, Nicola P.; Baxter, Roger] Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA.
[Benson, Patti; Jackson, Lisa] Grp Hlth Ctr Hlth Studies, Seattle, WA USA.
[Lieu, Tracy] Harvard Univ, Sch Med, Dept Populat Med, Boston, MA USA.
[Lieu, Tracy] Harvard Pilgrim Hlth Care Inst, Boston, MA USA.
[Naleway, Allison] Kaiser Permanente NW, Portland, OR USA.
[Belongia, Edward] Marshfield Clin Res Fdn, Marshfield, WI USA.
[Glanz, Jason; Hambidge, Simon J.] Kaiser Permanente Inst Hlth Res, Denver, CO USA.
[Hambidge, Simon J.] Denver Hlth Community Hlth Serv, Denver, CO USA.
[Jacobsen, Steven J.] Kaiser Permanente So Calif, Pasadena, CA USA.
[Nordin, Jim] HealthPartners Res Fdn, Minneapolis, MN USA.
RP Baggs, J (reprint author), Ctr Dis Control & Prevent, Immunizat Safety Off, 1600 Clifton Rd,Mail Stop D25, Atlanta, GA 30333 USA.
EM jbaggs@cdc.gov
OI Naleway, Allison/0000-0001-5747-4643; Baggs, James/0000-0003-0757-4683;
Jacobsen, Steven/0000-0002-8174-8533
FU VSD; CDC; Sanofi Pasteur; MedImmune; Novartis; GlaxoSmithKline; Pfizer;
Merck; National Institutes of Health; Wyeth (Pfizer); Merck Research
Laboratories; Merck Co; MedImmune (now AstraZeneca)
FX This study was supported, in part, by the VSD contract with America's
Health Insurance Plans, funded by the CDC.; Dr Baxter has received
research grants from Sanofi Pasteur, MedImmune, Novartis,
GlaxoSmithKline, Pfizer, and Merck; Dr Jackson has received research
funding related to vaccines from the CDC, National Institutes of Health,
Wyeth (Pfizer), Novartis, Sanofi Pasteur, and GlaxoSmithKline and has
served as an advisory board member for Wyeth (Pfizer), Novartis, and
GlaxoSmithKline; Dr Jacobsen has received grant funding from and served
as an unpaid consultant to Merck Research Laboratories; Dr Klein has
received research support from GlaxoSmithKline, Merck & Co, Sanofi
Pasteur, Wyeth (Pfizer), Novartis, and MedImmune; and Mr Lewis in the
past 3 years has worked on grants funded by Merck, Wyeth (Pfizer),
Novartis, Sanofi Pasteur, GlaxoSmithKline, and MedImmune (now
AstraZeneca). The other authors have indicated they have no financial
relationships relevant to this article to disclose.
NR 63
TC 122
Z9 122
U1 2
U2 8
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
SU 1
BP S45
EP S53
DI 10.1542/peds.2010-1722H
PG 9
WC Pediatrics
SC Pediatrics
GA 846QK
UT WOS:000296918100008
PM 21502240
ER
PT J
AU Haber, P
Iskander, J
Walton, K
Campbell, SR
Kohl, KS
AF Haber, Penina
Iskander, John
Walton, Kimp
Campbell, Scott R.
Kohl, Katrin S.
TI Internet-Based Reporting to the Vaccine Adverse Event Reporting System:
A More Timely and Complete Way for Providers to Support Vaccine Safety
SO PEDIATRICS
LA English
DT Article
DE vaccine safety; vaccine adverse event; electronic reporting
ID SMALLPOX VACCINATION; UNITED-STATES; VAERS; INTUSSUSCEPTION;
SURVEILLANCE; INFORMATION
AB BACKGROUND: On March 22, 2002, Internet-based reports (IBRs) were added to the Vaccine Adverse Event Reporting System (VAERS) to allow rapid, expedited reporting of adverse events (AEs) in anticipation of wider use of counter-bioterrorism vaccines such as those against smallpox and anthrax.
OBJECTIVES: To evaluate the impact of IBRs on the timeliness and completeness of vaccine AE reporting.
METHODS: To evaluate timeliness and completeness, we compared the proportions of IBRs with non-Internet-based reports (NIBRs). Report interval was analyzed for timeliness and age at vaccination, birth date, and onset date for report completeness. To evaluate the impact of the smallpox vaccination program, we compared smallpox vaccine reports separately. Because influenza vaccine is the most widely used vaccine in adults each year, we compared influenza vaccine reports separately.
RESULTS: During the study period, VAERS received 54 364 NIBRs (85.8%) and 9008 IBRs (14.2%). Sixteen percent (1455) of IBRs followed smallpox vaccination. Overall, for all vaccines and for smallpox vaccine alone, IBRs had a greater proportion of completeness and a shorter report interval. The proportion of most frequently reported AEs did not differ between IBRs and NIBRs. A higher proportion of adults (18-64 years old) who received influenza vaccine chose to complete an IBR (62% vs 48%).
CONCLUSIONS: The improved timeliness and completeness of IBRs allow VAERS to more rapidly detect new or rare vaccine AEs. This important advantage is critical in times of increased public concern about vaccine safety. Clinical vaccine providers should be aware of VAERS and use IBRs whenever feasible to report vaccine AEs. Pediatrics 2011;127:S39-S44
C1 [Haber, Penina; Iskander, John; Campbell, Scott R.; Kohl, Katrin S.] Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
[Walton, Kimp] Ctr Dis Control & Prevent, Off Informat Sci & Technol, Off Director, Natl Immunizat Program, Atlanta, GA 30333 USA.
RP Haber, P (reprint author), Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Mail Stop D-26,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM phaber@cdc.gov
NR 26
TC 11
Z9 11
U1 1
U2 2
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
SU 1
BP S39
EP S44
DI 10.1542/peds.2010-1722G
PG 6
WC Pediatrics
SC Pediatrics
GA 846QK
UT WOS:000296918100007
PM 21502243
ER
PT J
AU Healy, CM
Pickering, LK
AF Healy, C. Mary
Pickering, Larry K.
TI How to Communicate With Vaccine-Hesitant Parents
SO PEDIATRICS
LA English
DT Article
DE vaccine safety; health care providers
ID AUTISM SPECTRUM DISORDERS; THIMEROSAL-CONTAINING VACCINES; HEALTH-CARE
PROVIDERS; DEVELOPMENTAL DISORDERS; CHILDHOOD VACCINES; CAUSAL
ASSOCIATION; UNITED-KINGDOM; MEASLES-VIRUS; MEDICAL HOME; NO EVIDENCE
AB Development of safe and effective vaccines is one the greatest medical triumphs. However, despite high immunization rates in the United States, 85% of health care providers (HCPs) will have a parent refuse a vaccine for his or her child each year. HCPs have the greatest influence on a parent's decision to vaccinate his or her child. To effectively communicate with vaccine-hesitant parents, HCPs must first understand the concerns of parents regarding immunization and understand influences that can lead to misinformation about the safety and effectiveness of vaccines. HCPs should establish an open, nonconfrontational dialogue with vaccine-hesitant parents at an early stage and provide unambiguous, easily comprehensible answers about known vaccine adverse events and provide accurate information about vaccination. Personal stories and visual images of patients and parents affected by vaccine-preventable diseases and reports of disease outbreaks serve as useful reminders of the need to maintain high immunization rates. Ongoing dialogue including provider recommendations may successfully reassure vaccine-hesitant parents that immunization is the best and safest option for their child. Pediatrics 2011;127:S127-S133
C1 [Pickering, Larry K.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
[Pickering, Larry K.] Emory Univ, Sch Med, Atlanta, GA USA.
[Healy, C. Mary] Texas Childrens Hosp, Ctr Vaccine Awareness & Res, Houston, TX 77030 USA.
[Healy, C. Mary] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
RP Pickering, LK (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,Mailstop E-05, Atlanta, GA 30333 USA.
EM lpickering@cdc.gov
FU Sanofi Pasteur
FX Dr Healy has a research grant from Sanofi Pasteur and has served on a
scientific advisory board for Novartis Vaccines; Dr Pickering has
indicated he has no financial relationships relevant to this article to
disclose.
NR 56
TC 50
Z9 52
U1 3
U2 28
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
SU 1
BP S127
EP S133
DI 10.1542/peds.2010-1722S
PG 7
WC Pediatrics
SC Pediatrics
GA 846QK
UT WOS:000296918100019
PM 21502238
ER
PT J
AU Hussain, H
Omer, SB
Manganello, JA
Kromm, EE
Carter, TC
Kan, L
Stokley, S
Halsey, NA
Salmon, DA
AF Hussain, Hamidah
Omer, Saad B.
Manganello, Jennifer A.
Kromm, Elizabeth Edsall
Carter, Terrell C.
Kan, Lilly
Stokley, Shannon
Halsey, Neal A.
Salmon, Daniel A.
TI Immunization Safety in US Print Media, 1995-2005
SO PEDIATRICS
LA English
DT Article
DE vaccine; adverse effects; safety; newspaper; mandatory programs; content
analysis
ID ANTIVACCINATION WEB SITES; NEWSPAPER COVERAGE; HIGH AGREEMENT;
PUBLIC-HEALTH; UNITED-STATES; 2 PARADOXES; NEWS MEDIA; LOW KAPPA;
VACCINE; PRESS
AB OBJECTIVE: To identify and describe vaccine safety in US newspaper articles.
METHODS: Articles (1147) from 44 states and Washington, DC, between January 1, 1995, and July 15, 2005, were identified by using the search terms "immunize or vaccine" and "adverse events or safety or exemption or danger or risk or damage or injury or side effect" and were coded by using a standardized data-collection instrument.
RESULTS: The mean number of vaccine-safety articles per state was 26. Six (not mutually exclusive) topics were identified: vaccine-safety concerns (46%); vaccine policy (44%); vaccines are safe (20%); immunizations are required (10%); immunizations are not required (8%); and state/school exemption (8%). Three spikes in the number of newspaper articles about vaccine-safety issues were observed: in 1999 regarding rotavirus vaccine and in 2002 and 2003 regarding smallpox vaccine. Excluding articles that referred to rotavirus and smallpox vaccines, 37% of the articles had a negative take-home message.
CONCLUSION: Ongoing monitoring of news on vaccine safety may help the content and framing of vaccine-safety messages. Pediatrics 2011;127:S100-S106
C1 [Hussain, Hamidah; Omer, Saad B.; Kromm, Elizabeth Edsall; Kan, Lilly; Halsey, Neal A.; Salmon, Daniel A.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA.
[Manganello, Jennifer A.] SUNY Albany, Sch Publ Hlth, Dept Hlth Policy Management & Behav, Albany, NY USA.
[Carter, Terrell C.] PATH Malaria Vaccine Initiat, Bethesda, MD USA.
[Stokley, Shannon] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
RP Hussain, H (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, 615 N Wolfe St,Room W5041, Baltimore, MD 21205 USA.
EM hhussain@jhsph.edu
RI Omer, Saad/K-1182-2012
OI Omer, Saad/0000-0002-5383-3474
FU Johns Hopkins University; Crucell; Intercell; Centers for Disease
Control and Prevention [U01 IP000032]
FX Dr Halsey has received compensation for serving on safety-monitoring
committees for Novartis and Merck, research grants through Johns Hopkins
University from Crucell and Intercell for studies of unrelated vaccines
in Guatemala, and an honorarium for attending a meeting with Sanofi
Pasteur MSD, a company in Europe; the other authors have indicated they
have no financial relationships relevant to this article to disclose.;
This investigation was funded by Centers for Disease Control and
Prevention grant U01 IP000032.
NR 42
TC 12
Z9 12
U1 0
U2 2
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
SU 1
BP S100
EP S106
DI 10.1542/peds.2010-1722O
PG 7
WC Pediatrics
SC Pediatrics
GA 846QK
UT WOS:000296918100015
PM 21502237
ER
PT J
AU Kennedy, A
Basket, M
Sheedy, K
AF Kennedy, Allison
Basket, Michelle
Sheedy, Kristine
TI Vaccine Attitudes, Concerns, and Information Sources Reported by Parents
of Young Children: Results From the 2009 HealthStyles Survey
SO PEDIATRICS
LA English
DT Article
DE vaccines; attitudes; parents
ID SCHOOL IMMUNIZATION REQUIREMENTS; ROUTINE CHILDHOOD IMMUNIZATIONS;
UNITED-STATES; SAFETY CONCERNS; PHILOSOPHICAL EXEMPTIONS; NONMEDICAL
EXEMPTIONS; DECISION-MAKING; PERTUSSIS; MEASLES; INTERVENTIONS
AB OBJECTIVE: To describe the vaccine-related attitudes, concerns, and information sources of US parents of young children.
METHODS: We calculated weighted proportions and 95% confidence intervals for vaccine-related attitudes, concerns, and information sources of parents with at least 1 child aged 6 years or younger who participated in the 2009 HealthStyles survey.
RESULTS: The overall response rate for the survey was 65% (4556 of 7004); 475 respondents were parents or guardians ("parents") of at least 1 child aged 6 years or younger. Among those respondents, nearly all (93.4%) reported that their youngest child had or would receive all recommended vaccines. The majority of parents reported believing that vaccines were important to children's health (79.8%) and that they were either confident or very confident in vaccine safety (79.0%). The vaccine-related concern listed most often by parents was a child's pain from the shots given in 1 visit (44.2%), followed by a child getting too many vaccines at 1 doctor's visit (34.2%). When asked to list their most important sources of information on vaccines, the most common response was a child's doctor or nurse (81.7%).
CONCLUSIONS: To maintain and improve on the success of childhood vaccines in preventing disease, a holistic approach is needed to address parents' concerns in an ongoing manner. Listening and responding in ways and with resources that address specific questions and concerns could help parents make more informed vaccination decisions. Pediatrics 2011;127:S92-S99
C1 [Kennedy, Allison] Ctr Dis Control & Prevent, Immunizat Serv Div, Atlanta, GA USA.
[Basket, Michelle; Sheedy, Kristine] Ctr Dis Control & Prevent, Hlth Commun Sci Off, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
RP Kennedy, A (reprint author), 1600 Clifton Rd NE,Mail Stop E-52, Atlanta, GA 30333 USA.
EM akennedy@cdc.gov
NR 35
TC 71
Z9 71
U1 3
U2 16
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
SU 1
BP S92
EP S99
DI 10.1542/peds.2010-1722N
PG 8
WC Pediatrics
SC Pediatrics
GA 846QK
UT WOS:000296918100014
PM 21502253
ER
PT J
AU LaRussa, PS
Edwards, KM
Dekker, CL
Klein, NP
Halsey, NA
Marchant, C
Baxter, R
Engler, RJM
Kissner, J
Slade, BA
AF LaRussa, Philip S.
Edwards, Kathryn M.
Dekker, Cornelia L.
Klein, Nicola P.
Halsey, Neal A.
Marchant, Colin
Baxter, Roger
Engler, Renata J. M.
Kissner, Jennifer
Slade, Barbara A.
TI Understanding the Role of Human Variation in Vaccine Adverse Events: The
Clinical Immunization Safety Assessment Network
SO PEDIATRICS
LA English
DT Article
DE CISA Network; vaccine safety; adverse events following immunization
ID DATA-COLLECTION; CASE-DEFINITION; GUIDELINES; EXPOSURE; VIRUS; RISK; TIV
AB The Clinical Immunization Safety Assessment (CISA) Network is a collaboration between the Centers for Disease Control and Prevention (CDC) and 6 academic medical centers to provide support for immunization safety assessment and research. The CISA Network was established by the CDC in 2001 with 4 primary goals: (1) develop research protocols for clinical evaluation, diagnosis, and management of adverse events following immunization (AEFI); (2) improve the understanding of AEFI at the individual level, including determining possible genetic and other risk factors for predisposed people and subpopulations at high risk; (3) develop evidence-based algorithms for vaccination of people at risk of serious AEFI; and (4) serve as subject-matter experts for clinical vaccine-safety inquiries. CISA Network investigators bring in-depth clinical, pathophysiologic, and epidemiologic expertise to assessing causal relationships between vaccines and adverse events and to understanding the pathogenesis of AEFI. CISA Network researchers conduct expert reviews of clinically significant adverse events and determine the validity of the recorded diagnoses on the basis of clinical and laboratory criteria. They also conduct special studies to investigate the possible pathogenesis of adverse events, assess relationships between vaccines and adverse events, and maintain a centralized repository for clinical specimens. The CISA Network provides specific clinical guidance to both health care providers who administer vaccines and those who evaluate and treat patients with possible AEFI. The CISA Network plays an important role in providing critical immunization-safety data and expertise to inform vaccine policy-makers. The CISA Network serves as a unique resource for vaccine-safety monitoring efforts conducted at the CDC. Pediatrics 2011;127:S65-S73
C1 [LaRussa, Philip S.] Columbia Univ, Dept Pediat, Div Pediat Infect Dis, New York, NY 10027 USA.
[Edwards, Kathryn M.; Kissner, Jennifer] Vanderbilt Univ, Dept Pediat, Vanderbilt Vaccine Res Program, Nashville, TN USA.
[Dekker, Cornelia L.] Stanford Univ, Dept Pediat, Sch Med, Div Pediat Infect Dis, Stanford, CA 94305 USA.
[Klein, Nicola P.; Baxter, Roger] Kaiser Permanente, Vaccine Study Ctr, Oakland, CA USA.
[Halsey, Neal A.] Johns Hopkins Sch Med, Dept Pediat, Baltimore, MD USA.
[Halsey, Neal A.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA.
[Marchant, Colin] Boston Med Ctr, Dept Pediat, Boston, MA USA.
[Engler, Renata J. M.] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Natl Branch, Washington, DC 20307 USA.
[Slade, Barbara A.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP LaRussa, PS (reprint author), Columbia Univ, Dept Pediat, Div Pediat Infect Dis, New York, NY 10027 USA.
EM plarussa@columbia.edu
FU National Institutes of Health (NIH); CDC [200-2002-00732]; Sanofi
Pasteur; Novartis; Wyeth; CSL; GlaxoSmithKline; Merck Co; Wyeth
(Pfizer); MedImmune; Johns Hopkins University; Berna; Intercel; Wyeth
(Pfizer Inc); Pfizer; Protein Sciences; Merck
FX Dr LaRussa receives contract funding from the National Institutes of
Health (NIH) and the CDC and currently serves on a Novartis data safety
monitoring board; Dr Edwards receives contract funding from the NIH and
the CDC, has received contract support within the past 3 years from
Sanofi Pasteur, Novartis, Wyeth, and CSL for the conduct of clinical
vaccine studies, and has served as a consultant to Nexbio and PATH; Dr
Dekker receives contract funding from the NIH and the CDC; Dr Klein
receives contract funding from the CDC and research support from
GlaxoSmithKline, Merck & Co, Sanofi Pasteur, Wyeth (Pfizer), Novartis
and MedImmune; Dr Halsey receives contract funding from the CDC and is
compensated for serving on safety monitoring committees for studies of
vaccines for Merck and Novartis, has received an honorarium for training
and support for travel from Sanofi-MSD, a company in France, has
research grants through Johns Hopkins University for studies of
unrelated vaccines in Guatemala from Berna and Intercel, and has
received support for a study of a Merck HPV vaccine in Peru but receives
no support for the effort in Peru; Dr Marchant receives contract funding
from the CDC and has performed clinical research for GlaxoSmithKline,
Sanofi Pasteur, Merck, Wyeth (Pfizer Inc), MedImmune, and Novartis, has
served as a consultant to GlaxoSmithKline, Sanofi Pasteur, MedImmune,
and Novartis, and has given lectures sponsored by GlaxoSmithKline and
Sanofi Pasteur; Dr Baxter receives contract funding from the CDC and
research grants from Sanofi Pasteur, MedImmune, Novartis,
GlaxoSmithKline, Pfizer, Protein Sciences, and Merck. Drs Engler,
Kissner, and Slade have indicated they have no financial relationships
relevant to this article to disclose.; This work was supported by CDC
contract 200-2002-00732.
NR 31
TC 17
Z9 17
U1 0
U2 1
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
SU 1
BP S65
EP S73
DI 10.1542/peds.2010-1722J
PG 9
WC Pediatrics
SC Pediatrics
GA 846QK
UT WOS:000296918100010
PM 21502239
ER
PT J
AU Miller, E
Batten, B
Hampton, L
Campbell, SR
Gao, JR
Iskander, J
AF Miller, Elaine
Batten, Brigid
Hampton, Lee
Campbell, Scott R.
Gao, Jinrong
Iskander, John
TI Tracking Vaccine-Safety Inquiries to Detect Signals and Monitor Public
Concerns
SO PEDIATRICS
LA English
DT Article
DE public inquiries; vaccine safety; vaccine adverse events
ID EVENT-REPORTING-SYSTEM; IMMUNIZATION INFORMATION HOTLINE; ADVERSE
EVENTS; PHARMACOVIGILANCE; VAERS
AB BACKGROUND: The Centers for Disease Control and Prevention frequently receives inquiries from health care providers, public health officials, and the general public seeking data or guidance on vaccine-safety issues. Past inquiries to public health authorities identified potential problems including viscerotropic illness rarely associated with yellow fever vaccination.
OBJECTIVE: To systematically describe vaccine-safety inquiries received at the Centers for Disease Control and Prevention.
METHODS: External and internal inquiries were recorded in a database from May 1, 2002 to May 31, 2009. Key variables analyzed included the source of the question, the type of information being sought, and the vaccine type(s) associated with the inquiry.
RESULTS: A total of 983 vaccine-safety inquiries were answered and analyzed. Health care workers were the source of 43% of the questions, and the general public accounted for 19% of the questions. Nearly half of the requests (49%) concerned information about the Vaccine Adverse Event Reporting System, and nearly one-fourth (21%) were requests from providers for clinical guidance. The most frequent specific topics of inquiry and vaccines involved were neurologic adverse events (AEs) temporally associated with vaccination (17%) and safety of all vaccines or childhood vaccines (20%), respectively.
CONCLUSIONS: Questions about rare but potentially serious AEs and general concerns about vaccine safety were encountered relatively frequently. The substantial number of clinically focused inquires may indicate a need for more provider support tools and resources. Tracking of inquiries can supplement information received through vaccine AE reporting and contribute to an enhanced scientific and communications response to vaccine-safety concerns. Pediatrics 2011;127:S87S91
C1 [Miller, Elaine; Campbell, Scott R.; Iskander, John] Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
[Batten, Brigid] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA.
[Gao, Jinrong] Ctr Dis Control & Prevent, Off Director, Coordinating Ctr Infect Dis, Atlanta, GA 30333 USA.
[Hampton, Lee] Yale Univ, Dept Pediat, New Haven, CT 06520 USA.
[Gao, Jinrong] SAIC Corp, Atlanta, GA USA.
RP Miller, E (reprint author), Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Mail Stop D-26,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM erm4@cdc.gov
NR 14
TC 4
Z9 4
U1 1
U2 1
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
SU 1
BP S87
EP S91
DI 10.1542/peds.2010-1722M
PG 5
WC Pediatrics
SC Pediatrics
GA 846QK
UT WOS:000296918100013
PM 21502241
ER
PT J
AU Salmon, DA
Akhtar, A
Mergler, MJ
Vannice, KS
Izurieta, H
Ball, R
Lee, GM
Vellozzi, C
Garman, P
Cunningham, F
Gellin, B
Koh, H
Lurie, N
AF Salmon, Daniel A.
Akhtar, Aysha
Mergler, Michelle J.
Vannice, Kirsten S.
Izurieta, Hector
Ball, Robert
Lee, Grace M.
Vellozzi, Claudia
Garman, Patrick
Cunningham, Francesca
Gellin, Bruce
Koh, Howard
Lurie, Nicole
CA H1N1 Working Grp Fed Immunization
TI Immunization-Safety Monitoring Systems for the 2009 H1N1 Monovalent
Influenza Vaccination Program
SO PEDIATRICS
LA English
DT Article
DE vaccine safety; H1N1 influenza
ID DEFENSE MEDICAL SURVEILLANCE; EVENT REPORTING SYSTEM; VACCINES; DISEASE;
COMPLICATIONS; EXPERIENCE
AB The effort to vaccinate the US population against the 2009 H1N1 influenza virus hinged, in part, on public confidence in vaccine safety. Early in the vaccine program, >20% of parents reported that they would not vaccinate their children. Concerns about the safety of the vaccines were reported by many parents as a factor that contributed to their intention to forgo vaccination (see www.hsph.harvard.edu/news/press-releases/2009-releases/survey-40-adults-absolutely-certain-h1n1vaccine.html and www.med.umich.edu/mott/npch/reports/h1n1.htm). The safety profiles of 2009 H1N1 monovalent influenza vaccines were anticipated to be (and have been) similar to those of seasonal influenza vaccines, for which an excellent safety profile has been demonstrated. Here we describe steps taken by the US government to (1) assess the key federal systems in place before 2009 for monitoring the safety of vaccines and (2) integrate and upgrade those systems for optimal vaccine-safety monitoring during the 2009 H1N1 monovalent influenza vaccination program. These efforts improved monitoring of 2009 H1N1 vaccine safety, hold promise for enhancing future national monitoring of vaccine safety, and may ultimately help improve public confidence in vaccines. Pediatrics 2011;127:S78-S86
C1 [Salmon, Daniel A.] US Dept HHS, Natl Vaccine Program Off, Off Publ Hlth & Sci, Off Secretary, Washington, DC 20201 USA.
[Izurieta, Hector] US FDA, Analyt Epidemiol Branch, Div Epidemiol, Rockville, MD 20857 USA.
[Akhtar, Aysha; Ball, Robert] US FDA, Off Biostat & Epidemiol, Ctr Biol Evaluat & Res, Rockville, MD 20857 USA.
[Lee, Grace M.] Harvard Univ, Sch Med, Dept Populat Med, Harvard Pilgrim Hlth Care Inst, Boston, MA USA.
[Lee, Grace M.] Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA.
[Lee, Grace M.] Dept Lab Med, Boston, MA USA.
[Vellozzi, Claudia] Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, Atlanta, GA USA.
[Garman, Patrick] USA, Mil Vaccine Agcy, Falls Church, VA USA.
[Cunningham, Francesca] Pharm Benefits Management Serv, Natl Ctr Patient Safety, Dept Vet Affairs, Washington, DC USA.
RP Salmon, DA (reprint author), US Dept HHS, Natl Vaccine Program Off, Off Publ Hlth & Sci, Off Secretary, 200 Independence Ave,SW Room 715H, Washington, DC 20201 USA.
EM daniel.salmon@hhs.gov
OI Krause, Philip/0000-0002-1045-7536; Hughes, Michelle/0000-0002-4436-2236
NR 27
TC 29
Z9 30
U1 0
U2 4
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
SU 1
BP S78
EP S86
DI 10.1542/peds.2010-1722L
PG 9
WC Pediatrics
SC Pediatrics
GA 846QK
UT WOS:000296918100012
PM 21502251
ER
PT J
AU Vannice, KS
Salmon, DA
Shui, I
Omer, SB
Kissner, J
Edwards, KM
Sparks, R
Dekker, CL
Klein, NP
Gust, DA
AF Vannice, Kirsten S.
Salmon, Daniel A.
Shui, Irene
Omer, Saad B.
Kissner, Jennifer
Edwards, Kathryn M.
Sparks, Robert
Dekker, Cornelia L.
Klein, Nicola P.
Gust, Deborah A.
TI Attitudes and Beliefs of Parents Concerned About Vaccines: Impact of
Timing of Immunization Information
SO PEDIATRICS
LA English
DT Article
DE vaccine information; vaccine safety; Centers for Disease Control and
Prevention; parental attitudes and beliefs
ID SAFETY; COMMUNICATION; CHALLENGES; PAMPHLETS; MOTHERS; CARE
AB OBJECTIVES: To determine if giving vaccine-information materials before the 2-month vaccination visit to mothers with concerns about vaccine safety positively changed their attitudes and beliefs about vaccine safety.
METHODS: Mothers who indicated concerns about infant vaccinations were recruited from 2 separate sites in Tennessee and California and were given vaccine information at 1 of 3 times: during a prenatal visit; a 1-week postpartum well-child visit; or a 2-month vaccination visit. A separate group of concerned mothers was assigned to be followed longitudinally at all 3 time points and was analyzed separately. The mothers reviewed a new vaccine-information pamphlet and Vaccine Information Statements (VIS) from the Centers for Disease Control and Prevention. Attitudes and beliefs about immunization were assessed both before and after the review of materials with written surveys.
RESULTS: A total of 272 mothers with immunization concerns participated in the study. After review of the materials, mothers in all groups were significantly more likely to respond positively to questions and statements supporting the safety and importance of vaccines. Mothers who received this information at earlier visits were not significantly more likely to respond positively than mothers who received the information at the child's 2-month vaccination visit; however, participating mothers did indicate a preference for receiving vaccine information before the first vaccination visit.
CONCLUSIONS: Distribution of the vaccine-information pamphlet and Vaccine Information Statements significantly improved attitudes about vaccination regardless of at what visit they were provided. Allowing adequate time to review vaccine information, even if done at the vaccination visit, may benefit concerned mothers. Pediatrics 2011;127:S120-S126
C1 [Vannice, Kirsten S.; Salmon, Daniel A.] US Dept HHS, Natl Vaccine Program Off, Washington, DC 20201 USA.
[Shui, Irene; Gust, Deborah A.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Omer, Saad B.] Emory Univ, Hubert Dept Global Hlth Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Kissner, Jennifer; Edwards, Kathryn M.; Sparks, Robert] Vanderbilt Univ, Med Ctr, Dept Pediat, Vanderbilt Vaccine Res Program, Nashville, TN 37232 USA.
[Dekker, Cornelia L.; Klein, Nicola P.] Stanford Univ, Div Pediat Infect Dis, Sch Med, Stanford, CA 94305 USA.
[Klein, Nicola P.] Kaiser Permanente, Vaccine Study Ctr, Oakland, CA USA.
RP Vannice, KS (reprint author), Johns Hopkins Sch Publ Hlth, 615 N Wolfe St, Baltimore, MD 21205 USA.
EM kvannice@jhsph.edu
RI Omer, Saad/K-1182-2012
OI Omer, Saad/0000-0002-5383-3474
FU GlaxoSmithKline; Merck Co; Sanofi Pasteur; Wyeth (Pfizer); Novartis;
MedImmune; Vaccine Attitudes and Risk Perception (VARP); Clinical
Immunization Safety Assessment (CISA) groups; National Institutes of
Health [T32HD046405]
FX Dr Klein has received research support from GlaxoSmithKline, Merck & Co,
Sanofi Pasteur, Wyeth (Pfizer), Novartis, and MedImmune; the other
authors have indicated they have no financial relationships relevant to
this article to disclose.; This study was performed in collaboration
between the Centers for Disease Control and Prevention-funded Vaccine
Attitudes and Risk Perception (VARP) and Clinical Immunization Safety
Assessment (CISA) groups. Ms Vannice was supported in part by a National
Institutes of Health Training Grant in International Maternal and Child
Health (T32HD046405).
NR 18
TC 28
Z9 28
U1 2
U2 11
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
SU 1
BP S120
EP S126
DI 10.1542/peds.2010-1722R
PG 7
WC Pediatrics
SC Pediatrics
GA 846QK
UT WOS:000296918100018
PM 21502250
ER
PT J
AU Yih, WK
Kulldorff, M
Fireman, BH
Shui, IM
Lewis, EM
Klein, NP
Baggs, J
Weintraub, ES
Belongia, EA
Naleway, A
Gee, J
Platt, R
Lieu, TA
AF Yih, W. Katherine
Kulldorff, Martin
Fireman, Bruce H.
Shui, Irene M.
Lewis, Edwin M.
Klein, Nicola P.
Baggs, James
Weintraub, Eric S.
Belongia, Edward A.
Naleway, Allison
Gee, Julianne
Platt, Richard
Lieu, Tracy A.
TI Active Surveillance for Adverse Events: The Experience of the Vaccine
Safety Datalink Project
SO PEDIATRICS
LA English
DT Article
DE vaccines; surveillance; epidemiologic methods; statistics
ID REAL-TIME SURVEILLANCE; IMMUNIZATION SAFETY; UPDATE; RISK
AB OBJECTIVE: To describe the Vaccine Safety Datalink (VSD) project's experience with population-based, active surveillance for vaccine safety and draw lessons that may be useful for similar efforts.
PATIENTS AND METHODS: The VSD comprises a population of 9.2 million people annually in 8 geographically diverse US health care organizations. Data on vaccinations and diagnoses are updated and extracted weekly. The safety of 5 vaccines was monitored, each with 5 to 7 prespecified outcomes. With sequential analytic methods, the number of cases of each outcome was compared with the number of cases observed in a comparison group or the number expected on the basis of background rates. If the test statistic exceeded a threshold, it was a signal of a possible vaccine-safety problem. Signals were investigated by using temporal scan statistics and analyses such as logistic regression.
RESULTS: Ten signals appeared over 3 years of surveillance: 1 signal was reported to external stakeholders and ultimately led to a change in national vaccination policy, and 9 signals were found to be spurious after rigorous internal investigation. Causes of spurious signals included imprecision in estimated background rates, changes in true incidence or coding over time, other confounding, inappropriate comparison groups, miscoding of outcomes in electronic medical records, and chance. In the absence of signals, estimates of adverse-event rates, relative risks, and attributable risks from up-to-date VSD data have provided rapid assessment of vaccine safety to policy-makers when concerns about a specific vaccine have arisen elsewhere.
CONCLUSIONS: Care with data quality, outcome definitions, comparison groups, and length of surveillance are required to enable detection of true safety problems while minimizing false signals. Some causes of false signals in the VSD system were preventable and have been corrected, whereas others will be unavoidable in any active surveillance system. Temporal scan statistics, analyses to control for confounding, and chart review are indispensable tools in signal investigation. The VSD's experience may inform new systems for active safety surveillance. Pediatrics 2011;127:S54-S64
C1 [Yih, W. Katherine; Kulldorff, Martin; Shui, Irene M.; Platt, Richard; Lieu, Tracy A.] Harvard Univ, Sch Med, Dept Populat Med, Boston, MA 02215 USA.
[Yih, W. Katherine; Kulldorff, Martin; Shui, Irene M.; Platt, Richard; Lieu, Tracy A.] Harvard Pilgrim Hlth Care Inst, Boston, MA 02215 USA.
[Fireman, Bruce H.] Kaiser Permanente, Div Res, Oakland, CA USA.
[Lewis, Edwin M.; Klein, Nicola P.] Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA.
[Baggs, James; Weintraub, Eric S.; Gee, Julianne] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA USA.
[Belongia, Edward A.] Marshfield Clin Res Fdn, Marshfield, WI USA.
[Naleway, Allison] Kaiser Permanente Ctr Hlth Res, Portland, OR USA.
RP Yih, WK (reprint author), Harvard Univ, Sch Med, Dept Populat Med, 133 Brookline Ave,6th Floor, Boston, MA 02215 USA.
EM katherine_yih@harvardpilgrim.org
RI Kulldorff, Martin/H-4282-2011;
OI Naleway, Allison/0000-0001-5747-4643; Kulldorff,
Martin/0000-0002-5284-2993; Baggs, James/0000-0003-0757-4683
FU Merck; Wyeth (now Pfizer); Novartis; Sanofi Pasteur; GlaxoSmithKline;
MedImmune (now AstraZeneca); Centers for Disease Control and Prevention
[200-2002-00732]
FX Mr Lewis and Dr Klein have received research support from Merck, Wyeth
(now Pfizer), Novartis, Sanofi Pasteur, GlaxoSmithKline, and MedImmune
(now AstraZeneca), and all the authors receive funding from the Centers
for Disease Control and Prevention as investigators or other staff of
the Vaccine Safety Datalink project.; This work was supported by funding
from the Centers for Disease Control and Prevention via America's Health
Insurance Plans (contract 200-2002-00732).
NR 25
TC 45
Z9 45
U1 0
U2 3
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
SU 1
BP S54
EP S64
DI 10.1542/peds.2010-1722I
PG 11
WC Pediatrics
SC Pediatrics
GA 846QK
UT WOS:000296918100009
PM 21502252
ER
PT J
AU Owusu-Edusei, K
Koski, KA
Ballard, RC
AF Owusu-Edusei, Kwame, Jr.
Koski, Kathryn A.
Ballard, Ronald C.
TI The Tale of Two Serologic Tests to Screen for Syphilis-Treponemal and
Nontreponemal: Does the Order Matter?
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Article
ID SUB-SAHARAN AFRICA; RANDOMIZED CONTROLLED-TRIAL; COST-EFFECTIVENESS
ANALYSES; ADVERSE PREGNANCY OUTCOMES; RAPID PLASMA REAGIN; RURAL
SOUTH-AFRICA; CONGENITAL-SYPHILIS; ANTENATAL SYPHILIS; MATERNAL
SYPHILIS; DEMONSTRATION PROJECT
AB Background: Standard syphilis screening involves an initial screening with a nontreponemal test and confirmation of positives with a treponemal test. However, some laboratories have reversed the order. There is no detailed quantitative and qualitative evaluation for the order of testing. In this study, we analyzed the health and economic outcomes of the order of testing for the 2 serologic tests used in syphilis screening under pure screening settings.
Methods: We used a cohort decision analysis to examine the health and economic outcomes of the screening algorithms for low and high prevalence settings. The 2-step algorithms were nontreponemal followed by treponemal (Nontrep-First) and treponemal followed by nontreponemal (Trep-First). We included the 1-step algorithms (treponemal only [Trep-Only] and an on-site nontreponemal only [Nontrep-Only]) for comparison. We estimated overtreatment rates and the number of confirmatory tests required for each algorithm.
Results: For a cohort of 10,000 individuals, our results indicated that the overtreatment rates were substantially higher (more than 3 times) for the 1-step algorithms, although they treated a higher number of cases (over 15%). The 2-step algorithms detected and treated the same number of individuals. Among the 2-step algorithms, the Nontrep-First was more cost-effective in the low prevalence setting ($1400 vs. $1500 per adverse outcome prevented) and more cost-saving ($102,000 vs. $84,000) in the high prevalence setting.
Conclusions: The difference in cost was largely due to the substantially higher number of confirmatory tests required for the Trep-First algorithm, although the number of cases detected and treated was the same.
C1 [Owusu-Edusei, Kwame, Jr.; Koski, Kathryn A.; Ballard, Ronald C.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA.
RP Owusu-Edusei, K (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd,MS E-80, Atlanta, GA 30333 USA.
EM kowusuedusei@cdc.gov
NR 62
TC 12
Z9 12
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-5717
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD MAY
PY 2011
VL 38
IS 5
BP 448
EP 456
DI 10.1097/OLQ.0b013e3182036a0f
PG 9
WC Infectious Diseases
SC Infectious Diseases
GA 749LN
UT WOS:000289468500019
PM 21183862
ER
PT J
AU Schuetz, AN
Guarner, J
Packard, MM
Zaki, SR
Shehata, BM
Opreas-Ilies, G
AF Schuetz, Audrey N.
Guarner, Jeannette
Packard, Michelle M.
Zaki, Sherif R.
Shehata, Bahig M.
Opreas-Ilies, Gabriela
TI Infectious Disease Immunohistochemistry in Placentas from HIV-Positive
and HIV-Negative Patients
SO PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
LA English
DT Article
DE HIV; human immunodeficiency virus; immunohistochemistry; infectious
diseases; placenta
ID IMMUNODEFICIENCY-VIRUS TYPE-1; PERINATAL TRANSMISSION;
CONGENITAL-SYPHILIS; SEROPOSITIVE WOMEN; CHILD TRANSMISSION;
RISK-FACTORS; PATHOLOGY; ASSAYS; CHORIOAMNIONITIS; PREVENTION
AB Studies comparing placental pathology between human immunodeficiency virus (HIV)-positive and HIV-negative patients have shown conflicting results. In addition, few studies have evaluated the infectious etiology of placental inflammation in HIV-positive patients. We examined a cohort of placentas from 73 HIV-positive and 41 HIV-negative patients to gain a better understanding of the spectrum of placental inflammatory lesions. Bacterial and viral immunohistochemistry (IHC) was run on a subset of placentas (12 HIV-positive and 7 HIV-negative) with the greatest amount of inflammation. Although few histologic differences were seen between the HIV-positive and HIV-negative groups, chorioamnionitis was of a higher stage in the HIV-positive placentas. An infectious agent was found by IHC in 3 of 7 HIV-negative patients (2 Neisseria spp. and 1 group B Streptococcus). One HIV-positive placenta showed gram-positive cocci on fetal membranes; organisms were not detected by IHC. In 2 patients, the etiologic agent was not suspected prior to IHC. This study identified that acute inflammation is less common in placentas from HIV-positive patients, compared with HIV-negative patients. However, when severe inflammation is present, infectious organisms may be identified by IHC, providing a more specific diagnosis and offering a beneficial impact in maternal and fetal management.
C1 [Schuetz, Audrey N.] New York Presbyterian Hosp, Dept Pathol & Lab Med, Weill Cornell Med Ctr, New York, NY USA.
[Guarner, Jeannette; Zaki, Sherif R.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Guarner, Jeannette] Emory Univ Hosp, Atlanta, GA 30322 USA.
[Packard, Michelle M.] Michigan State Univ, E Lansing, MI 48824 USA.
[Shehata, Bahig M.] Childrens Healthcare Atlanta, Dept Pathol & Lab Med, Atlanta, GA USA.
[Shehata, Bahig M.] Childrens Healthcare Atlanta, Dept Pediat, Atlanta, GA USA.
[Opreas-Ilies, Gabriela] Emory Univ, Sch Med, Atlanta, GA USA.
[Opreas-Ilies, Gabriela] Grady Mem Hosp, Atlanta, GA USA.
RP Schuetz, AN (reprint author), New York Presbyterian Hosp, Dept Pathol & Lab Med, Weill Cornell Med Ctr, New York, NY USA.
EM ans9112@med.cornell.edu
RI Guarner, Jeannette/B-8273-2013
NR 27
TC 2
Z9 2
U1 0
U2 3
PU ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 1093-5266
J9 PEDIATR DEVEL PATHOL
JI Pediatr. Dev. Pathol.
PD MAY
PY 2011
VL 14
IS 3
BP 180
EP 188
DI 10.2350/10-04-0817-OA.1
PG 9
WC Pathology; Pediatrics
SC Pathology; Pediatrics
GA 814LE
UT WOS:000294453700002
PM 21054157
ER
PT J
AU Doyle, MS
Swope, BN
Hogsette, JA
Burkhalter, KL
Savage, HM
Nasci, RS
AF Doyle, Michael S.
Swope, Bethany N.
Hogsette, Jerome A.
Burkhalter, Kristen L.
Savage, Harry M.
Nasci, Roger S.
TI Vector Competence of the Stable Fly (Diptera: Muscidae) for West Nile
Virus
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE Stomoxys calcitrans; biological transmission; mechanical transmission;
Pelecanus erythrorhynchos; West Nile virus
ID FIELD-COLLECTED MOSQUITOS; EQUINE INFECTIOUS-ANEMIA; AMERICAN WHITE
PELICANS; CULEX-PIPIENS COMPLEX; STOMOXYS-CALCITRANS L; MECHANICAL
TRANSMISSION; FLIES DIPTERA; BOVINE LEUKOSIS; NORTH-AMERICA; SHELBY
COUNTY
AB In 2006-2007, stable flies, Stomoxys calcitrans (L.) (Diptera: Muscidae), were suspected of being enzootic vectors of West Nile virus (family Flaviviridae, genus Flavivirus, WNV) during a die-off of American white pelicans (Pelecanus erythrorhynchos Gmelin) (Pelecanidae) in Montana, USA. WNV-positive stable flies were observed feeding en masse on incapacitated, WNV-positive pelicans, arousing suspicions that the flies could have been involved in WNV transmission among pelicans, and perhaps to livestock and humans. We assessed biological transmission by infecting stable flies intrathoracically with WNV and testing them at 2-d intervals over 20 d. Infectious WNV was detected in fly bodies in decreasing amounts over time for only the first 6 d postinfection, an indication that WNV did not replicate within fly tissues and that stable flies cannot biologically transmit WNV. We assessed mechanical transmission using a novel technique. Specifically, we fed WNV-infected blood to individual flies by using a cotton swab (i.e., artificial donor), and at intervals of 1 min-24 h, we allowed flies to refeed on a different swab saturated with WNV-negative blood (i.e., artificial recipient). Flies mechanically transmitted viable WNV from donor to recipient swabs for up to 6 h postinfection, with the majority of the transmission events occurring within the first hour. Flies mechanically transmitted WNV RNA to recipient swabs for up to 24 h, mostly within the first 6 h. Given its predilection to feed multiple times when disturbed, these findings support the possibility that the stable fly could mechanically transmit WNV.
C1 [Doyle, Michael S.; Swope, Bethany N.; Burkhalter, Kristen L.; Savage, Harry M.; Nasci, Roger S.] Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO 80521 USA.
[Hogsette, Jerome A.] ARS, USDA, Ctr Med Agr & Vet Entomol, Gainesville, FL 32608 USA.
RP Doyle, MS (reprint author), Ctr Dis Control & Prevent, Arboviral Dis Branch, 3150 Rampart Rd, Ft Collins, CO 80521 USA.
EM mdoyle@cdc.gov
NR 52
TC 11
Z9 12
U1 0
U2 22
PU ENTOMOLOGICAL SOC AMER
PI LANHAM
PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA
SN 0022-2585
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD MAY
PY 2011
VL 48
IS 3
BP 656
EP 668
DI 10.1603/ME10167
PG 13
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA 810JY
UT WOS:000294122800023
PM 21661328
ER
PT J
AU Barrera, R
Amador, M
Young, G
Komar, N
AF Barrera, Roberto
Amador, Manuel
Young, Ginger
Komar, Nicholas
TI Mosquito (Diptera: Culicidae) Bloodmeal Sources During a Period of West
Nile Virus Transmission in Puerto Rico
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE West Nile virus; ecology; mosquito; arbovirus vector; reservoir host
ID HOST-FEEDING PATTERNS; FLORIDA MOSQUITOS; CULEX
AB Host bloodmeals of indigenous Caribbean mosquitoes have not been studied previously. We identified vertebrate DNA in 90 blood-engorged mosquitoes belonging to four genera (Aedes, Culex, Deinocerites, and Uranotaenia) and 12 species that were collected in Puerto Rico within a geographic and temporal focus of West Nile virus transmission in 2007. It was found that 62 (68.8%) bloodmeals were from reptiles, 18 (20.0%) from birds, and 10 (11.1%) from mammals. Only one bloodmeal of 18 derived from Culex (Culex) species was passerine, suggesting a preference for nonpasserine birds and other vertebrates (i.e., reptiles) among the candidate WNV vectors. We interpret the results with respect to vectorial capacity for West Nile virus, an emerging arbovirus throughout the Caribbean Basin.
C1 [Young, Ginger; Komar, Nicholas] CDC, Arboviral Dis Branch, Ft Collins, CO 80521 USA.
EM rbarrera@cdc.gov
FU Centers for Disease Control and Prevention
FX Numerous private property owners granted permission for field studies,
in particular the managers of the Roosevelt Roads Naval Base. Jesus
Flores, Orlando Gonzalez, Francisco Medina, Juan Medina, and others
provided field assistance and laboratory support. This work was funded
by the Centers for Disease Control and Prevention. Support for employees
of the Puerto Rico Department of Health was administered through a
Cooperative Agreement.
NR 18
TC 5
Z9 5
U1 2
U2 11
PU ENTOMOLOGICAL SOC AMER
PI LANHAM
PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA
SN 0022-2585
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD MAY
PY 2011
VL 48
IS 3
BP 701
EP 704
DI 10.1603/ME10281
PG 4
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA 810JY
UT WOS:000294122800029
PM 21661334
ER
PT J
AU Larsen, MD
Schenker, N
Little, R
AF Larsen, Michael D.
Schenker, Nathaniel
Little, Roderick
TI Discussion of "Calibrated Bayes, for Statistics in General, and Missing
Data in Particular" by R. J. A. Little
SO STATISTICAL SCIENCE
LA English
DT Article
ID MULTIPLE-IMPUTATION; INFORMATION; MODEL; INFERENCES; INCOME; RATES
C1 [Larsen, Michael D.] George Washington Univ, Ctr Biostat, Rockville, MD 20852 USA.
[Schenker, Nathaniel] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
[Little, Roderick] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
RP Larsen, MD (reprint author), George Washington Univ, Ctr Biostat, 6110 Execut Blvd,Suite 750, Rockville, MD 20852 USA.
EM mlarsen@bsc.gwu.edu; nschenker@cdc.gov; rlittle@umich.edu
NR 35
TC 0
Z9 0
U1 1
U2 3
PU INST MATHEMATICAL STATISTICS
PI CLEVELAND
PA 3163 SOMERSET DR, CLEVELAND, OH 44122 USA
SN 0883-4237
J9 STAT SCI
JI Stat. Sci.
PD MAY
PY 2011
VL 26
IS 2
SI SI
BP 175
EP 186
DI 10.1214/10-STS318B
PG 12
WC Statistics & Probability
SC Mathematics
GA 808NV
UT WOS:000293986600003
ER
PT J
AU Hawkins, JL
Chang, J
Palmer, SK
Gibbs, CP
Callaghan, WM
AF Hawkins, Joy L.
Chang, Jeani
Palmer, Susan K.
Gibbs, Charles P.
Callaghan, William M.
TI Anesthesia-Related Maternal Mortality in the United States: 1979-2002
EDITORIAL COMMENT
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Editorial Material
C1 [Hawkins, Joy L.] Univ Colorado, Dept Anesthesiol, Sch Med, Aurora, CO USA.
Ctr Dis Control & Prevent, Atlanta, GA USA.
Oregon Anesthesiol Grp, Portland, OR USA.
Univ Florida, Sch Med, Dept Anesthesiol, Gainesville, FL USA.
RP Hawkins, JL (reprint author), Univ Colorado, Dept Anesthesiol, Sch Med, Aurora, CO USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7828
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD MAY
PY 2011
VL 66
IS 5
BP 263
EP 264
DI 10.1097/OGX.0b013e318229426a
PG 2
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 797KT
UT WOS:000293127200002
ER
PT J
AU Shimokura, G
Chai, F
Weber, DJ
Samsa, GP
Xia, GL
Nainan, OV
Tobler, LH
Busch, MP
Alter, MJ
AF Shimokura, Gayle
Chai, Feng
Weber, David J.
Samsa, Gregory P.
Xia, Guo-liang
Nainan, Omana V.
Tobler, Leslie H.
Busch, Michael P.
Alter, Miriam J.
TI Patient-Care Practices Associated with an Increased Prevalence of
Hepatitis C Virus Infection among Chronic Hemodialysis Patients
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Article
ID PATIENTS RECEIVING HEMODIALYSIS; HCV INFECTION; UNITED-STATES; HAND
HYGIENE; TRANSMISSION; DIALYSIS; SURVIVAL; CONTAMINATION; OUTBREAK; RISK
AB OBJECTIVE. To identify patient-care practices related to an increased prevalence of hepatitis C virus (HCV) infection among chronic hemodialysis patients.
DESIGN. Survey.
SETTING. Chronic hemodialysis facilities in the United States.
PARTICIPANTS. Equal-probability 2-stage cluster sampling was used to select 87 facilities from all Medicare-approved providers treating 30-150 patients; 53 facilities and 2,933 of 3,680 eligible patients agreed to participate.
METHODS. Patients were tested for HCV antibody and HCV RNA. Data on patient-care practices were collected using direct observation.
RESULTS. The overall prevalence of HCV infection was 9.9% (95% confidence interval [CI], 8.2%-11.6%); only 2 of 294 HCV-positive patients were detected solely by HCV RNA testing. After adjusting for non-dialysis-related HCV risk factors, patient-care practices independently associated with a higher prevalence of HCV infection included reusing priming receptacles without disinfection (odds ratio [OR], 2.3 [95% CI, 1.4-3.9]), handling blood specimens adjacent to medications and clean supplies (OR, 2.2 [95% CI, 1.3-3.6]), and using mobile carts to deliver injectable medications (OR, 1.7 [95% CI, 1.0-2.8]). Independently related facility covariates were at least 10% patient HCV infection prevalence (OR, 3.0 [95% CI, 1.8-5.2]), patient-to-staff ratio of at least 7 : 1 (OR, 2.4 [95% CI, 1.4-4.1]), and treatment duration of at least 2 years (OR, 2.4 [95% CI, 1.3-4.4]).
CONCLUSIONS. This study provides the first epidemiologic evidence of associations between specific patient-care practices and higher HCV infection prevalence among hemodialysis patients. Staff should review practices to ensure that hemodialysis-specific infection control practices are being implemented, especially handling clean and contaminated items in separate areas, reusing items only if disinfected, and prohibiting mobile medication and clean supply carts within treatment areas. Infect Control Hosp Epidemiol 2011; 32(5): 415-424
C1 [Alter, Miriam J.] Univ Texas Med Branch, Dept Internal Med, Galveston, TX 77555 USA.
[Shimokura, Gayle; Weber, David J.; Samsa, Gregory P.] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
[Chai, Feng; Xia, Guo-liang; Nainan, Omana V.; Alter, Miriam J.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA.
[Tobler, Leslie H.; Busch, Michael P.] Blood Syst Res Inst, San Francisco, CA USA.
RP Alter, MJ (reprint author), Univ Texas Med Branch, Dept Internal Med, 301 Univ Blvd,Mail Route 0435, Galveston, TX 77555 USA.
EM mjalter@utmb.edu
FU Centers for Disease Control and Prevention (CDC) through the Association
of Schools of Public Health [U36/CCU300430-18, S-16/16-CID97-001]; Ortho
Diagnostics; GlaxoSmithKline; General Clinical Research Center
[RR00046]; National Institutes of Health [RO1-HL-076902]
FX This research was supported by a cooperative agreement and fellowship
(to G. S.) from the Centers for Disease Control and Prevention (CDC)
through the Association of Schools of Public Health (grant
U36/CCU300430-18 and fellowship S-16/16-CID97-001); short-term training
opportunities from the CDC through the Association of Teachers of
Preventive Medicine and the Research Participation Program administered
by the Oak Ridge Institute for Science and Education through an
interagency agreement between the US Department of Energy and the CDC
(to G. S.); unconditional salary support from Ortho Diagnostics and
GlaxoSmithKline (to G. S.); the General Clinical Research Center (grant
RR00046 to D.J.W.); and the National Institutes of Health (grant
RO1-HL-076902 to M. P. B. and L. H. T.). The CDC assisted in the design
and conduct of the study; collection, management, analysis, and
interpretation of the data; and preparation and review of the
manuscript.
NR 40
TC 17
Z9 19
U1 0
U2 3
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0899-823X
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD MAY
PY 2011
VL 32
IS 5
BP 415
EP 424
DI 10.1086/659407
PG 10
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 791GE
UT WOS:000292652100001
PM 21515970
ER
PT J
AU Schwartz, DN
Evans, RS
Camins, BC
Khan, YM
Lloyd, JF
Shehab, N
Stevenson, K
AF Schwartz, David N.
Evans, R. Scott
Camins, Bernard C.
Khan, Yosef M.
Lloyd, James F.
Shehab, Nadine
Stevenson, Kurt
CA Ctr Dis Control Prevention Epictr
TI Deriving Measures of Intensive Care Unit Antimicrobial Use from
Computerized Pharmacy Data: Methods, Validation, and Overcoming Barriers
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Article
ID INFECTIOUS-DISEASES SOCIETY; ANTIBIOTIC USE; HOSPITALS; CONSUMPTION;
RESISTANCE; RECORDS; TRENDS; RECOMMENDATIONS; EPIDEMIOLOGY; SURVEILLANCE
AB OBJECTIVE. To outline methods for deriving and validating intensive care unit (ICU) antimicrobial utilization (AU) measures from computerized data and to describe programming problems that emerged.
DESIGN. Retrospective evaluation of computerized pharmacy and administrative data.
SETTING. ICUs from 4 academic medical centers over 36 months.
INTERVENTIONS. Investigators separately developed and validated programming code to report AU measures in selected ICUs. Use of antibacterial and antifungal drugs for systemic administration was categorized and expressed as antimicrobial-days (each day that each antimicrobial drug was given to each patient) and patient-days receiving antimicrobials (each day that any antimicrobial drug was given to each patient). Monthly rates were compiled and analyzed centrally, with ICU patient-days as the denominator. Results were validated against data collected from manual review of medical records. Frequent discussion among investigators aided identification and correction of programming problems.
RESULTS. AU data were successfully programmed though a reiterative process of computer code revision. After identifying and resolving major programming errors, comparison of computerized patient-level data with data collected by manual review of medical records revealed discrepancies in antimicrobial-days and patient-days receiving antimicrobials that ranged from less than 1% to 17.7%. The hospital from which numerator data were derived from electronic records of medication administration had the least discrepant results.
CONCLUSIONS. Computerized AU measures can be derived feasibly, but threats to validity must be sought out and corrected. The magnitude of discrepancies between computerized AU data and a gold standard based on manual review of medical records varies, with electronic records of medication administration providing maximal accuracy. Infect Control Hosp Epidemiol 2011;32(5):472-480
C1 [Schwartz, David N.] John H Stroger Jr Hosp Cook Cty, Div Infect Dis, Chicago, IL 60612 USA.
[Schwartz, David N.] Rush Med Coll, Chicago, IL 60612 USA.
[Evans, R. Scott; Lloyd, James F.] LDS Hosp Intermt Healthcare, Salt Lake City, UT USA.
[Evans, R. Scott] Univ Utah, Sch Med, Salt Lake City, UT USA.
[Camins, Bernard C.] Barnes Jewish Hosp, St Louis, MO 63110 USA.
[Camins, Bernard C.] Washington Univ, Sch Med, St Louis, MO USA.
[Khan, Yosef M.; Stevenson, Kurt] Ohio State Univ, Med Ctr, Columbus, OH 43210 USA.
[Khan, Yosef M.; Stevenson, Kurt] Ohio State Univ, Coll Med, Columbus, OH 43210 USA.
[Shehab, Nadine] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA.
RP Schwartz, DN (reprint author), John H Stroger Jr Hosp Cook Cty, Div Infect Dis, 1901 W Harrison St, Chicago, IL 60612 USA.
EM david.schwartz@hektoen.org
FU Centers for Disease Control and Prevention [1 U01 CI000327, 1 U01
CI000328, 1 U01 CI000333-01, 1 U01 CI000334-0]; National Institutes of
Health/National Center for Research Resources [TL1RR024995]
FX This work was supported by the Centers for Disease Control and
Prevention cooperative agreement 1 U01 CI000327, 1 U01 CI000328, 1 U01
CI000333-01, and 1 U01 CI000334-0. B. C. C. received salary support
through National Institutes of Health/National Center for Research
Resources grant TL1RR024995.
NR 37
TC 13
Z9 13
U1 0
U2 2
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 0899-823X
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD MAY
PY 2011
VL 32
IS 5
BP 472
EP 480
DI 10.1086/659760
PG 9
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 791GE
UT WOS:000292652100009
PM 21515978
ER
PT J
AU Dendukuri, N
Wang, LL
Hadgu, A
AF Dendukuri, Nandini
Wang, Liangliang
Hadgu, Alula
TI Evaluating Diagnostic Tests for Chlamydia trachomatis in the Absence of
a Gold Standard: A Comparison of Three Statistical Methods
SO STATISTICS IN BIOPHARMACEUTICAL RESEARCH
LA English
DT Article
DE Bayesian estimation; Biased estimator; Chlamydia trachomatis; Composite
reference standard; Latent class models
ID ACID AMPLIFICATION TESTS; LATENT CLASS MODELS; DISCREPANT ANALYSIS;
CONDITIONAL DEPENDENCE; ACCURACY; ERROR; INFECTIONS; PREVALENCE; BIAS
AB Studies designed to evaluate diagnostic tests for Chlamydia trachomatis typically involve a panel of new and established tests. Statistical analysis of these studies has proven challenging as no gold standard reference test is available. We illustrate a novel multiple latent variable model (MLVM), which improves over earlier methods by recognizing that different diagnostic tests for C. trachomatis may be measuring different targets. For example, nucleic acid amplification tests (NAATs) are designed to measure C. trachomatis DNA, while cell culture is designed to measure the presence of current C. trachomatis infection. The MLVM does not arbitrarily assume any test is perfect. Further, it provides separate sensitivity and specificity estimates with respect to each latent target. Using simulated and real data, we will contrast the performance of MLVM with two other methods for evaluating C. trachomatis tests: (i) the composite reference standard (CRS) approach, and (ii) the standard latent class model (TLCM). We show that the tests involved in the definition of the CRS are arbitrarily assumed to have perfect specificity, and that both the CRS and the TLCM assume that all tests are measuring the same latent variable, the "current infection." When these assumptions are not justified, as is frequently the case, the resulting estimates of sensitivity and specificity may be seriously biased. The MLVM attempts to address these problems.
C1 [Hadgu, Alula] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA.
[Dendukuri, Nandini] McGill Univ, Dept Med, Montreal, PQ H3A 2T5, Canada.
[Dendukuri, Nandini] McGill Univ, Dept Epidemiol, Montreal, PQ H3A 2T5, Canada.
[Dendukuri, Nandini] McGill Univ, Dept Biostat, Montreal, PQ H3A 2T5, Canada.
[Dendukuri, Nandini] McGill Univ, Dept Occupat Hlth, Montreal, PQ H3A 2T5, Canada.
[Dendukuri, Nandini] McGill Univ, Ctr Hlth, Montreal, PQ H3A 2T5, Canada.
[Wang, Liangliang] Univ British Columbia, Dept Biostat, Vancouver, BC V5Z 1M9, Canada.
RP Hadgu, A (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd,Mail Stop E-63, Atlanta, GA 30333 USA.
EM ahadgu@cdc.gov
FU Fonds de la Recherche en Sante Quebec
FX Nandini Dendukuri is supported by a Chercheur Boursier Junior 2 award
from the Fonds de la Recherche en Sante Quebec.
NR 32
TC 3
Z9 3
U1 3
U2 8
PU AMER STATISTICAL ASSOC
PI ALEXANDRIA
PA 732 N WASHINGTON ST, ALEXANDRIA, VA 22314-1943 USA
SN 1946-6315
J9 STAT BIOPHARM RES
JI Stat. Biopharm. Res.
PD MAY
PY 2011
VL 3
IS 2
BP 385
EP 397
DI 10.1198/sbr.2011.10005
PG 13
WC Mathematical & Computational Biology; Statistics & Probability
SC Mathematical & Computational Biology; Mathematics
GA 791QX
UT WOS:000292680800023
ER
PT J
AU Deak, E
Nelson, M
Hernandez-Rodriguez, Y
Gade, L
Baddley, J
Momany, M
Steele, C
Balajee, SA
AF Deak, Eszter
Nelson, Michael
Hernandez-Rodriguez, Yainitza
Gade, Lalitha
Baddley, John
Momany, Michelle
Steele, Chad
Balajee, S. Arunmozhi
TI Aspergillus terreus accessory conidia are multinucleated,
hyperpolarizing structures that display differential dectin staining and
can induce heightened inflammatory responses in a pulmonary model of
aspergillosis
SO VIRULENCE
LA English
DT Article
DE Aspergillus terreus; accessory conidia characterization; beta-glucan;
aspergillosis; pathogenesis
ID BETA-GLUCAN RECEPTOR; IMMUNE RECOGNITION; AMPHOTERICIN-B; FUMIGATUS;
DEFENSE; MACROPHAGES
AB In addition to phialidic conidia (PC), A. terreus produces accessory conidia (AC) both in vitro and in vivo. AC are distinct from PC in cell surface architecture, with the AC surfaces displaying more beta-glucan, a molecule that can be a trigger for the induction of inflammatory responses. The present study follows beta-glucan cell surface presentation throughout the course of germination of both types of conidia, and analyzes the differential capacity of AC and PC to elicit immune responses. Results show that AC display early, increased dectin-1 labeling on their cell surfaces compared to PC, and this differential dectin-1 labeling is sustained on the cell surface from the time of breaking dormancy through early germ tube emergence. Mouse alveolar macrophages showed a stronger inflammatory cytokine/chemokine response when challenged with AC than with PC in both ex vivo and in vivo experiments, correlating with the greater exposure of beta-glucan exhibited by AC. Further, histopathologic staining of the lungs from mice challenged with AC demonstrated heightened cell recruitment and increased inflammatory response compared to the lungs of mice challenged with PC. Our study also demonstrates that AC are multinucleate structures with the ability to germinate rapidly, polarizing in multiple directions and producing several hyphal extensions. We present evidence that A. terreus AC are phenotypically distinct from PC and can be potent activators of the innate immune mechanism thus possibly playing a role in this organism's pathogenesis.
C1 [Deak, Eszter; Gade, Lalitha; Balajee, S. Arunmozhi] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA.
[Nelson, Michael; Baddley, John; Steele, Chad] Univ Alabama, Dept Med, Birmingham, AL 35294 USA.
[Hernandez-Rodriguez, Yainitza; Momany, Michelle] Univ Georgia, Dept Plant Biol, Athens, GA 30602 USA.
RP Balajee, SA (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA.
EM fir3@cdc.gov
RI Momany, Michelle/L-2327-2016
FU NHLBI NIH HHS [R01 HL096702, R01 HL096702-01A1, R01 HL096702-01A1S1, R01
HL096702-03]; NIAID NIH HHS [R01 AI068917, R01 AI068917-01A2, R01
AI068917-02]
NR 27
TC 9
Z9 9
U1 0
U2 1
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 2150-5594
J9 VIRULENCE
JI Virulence
PD MAY-JUN
PY 2011
VL 2
IS 3
BP 200
EP 207
DI 10.4161/viru.2.3.15799
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 789OD
UT WOS:000292524300006
PM 21543882
ER
PT J
AU Bhengsri, S
Baggete, HC
Peruski, LF
Morway, C
Bai, Y
Fisk, TL
Sitdhirasdr, A
Maloney, SA
Dowell, SF
Kosoy, M
AF Bhengsri, Saithip
Baggete, Henry C.
Peruski, Leonard F.
Morway, Christina
Bai, Ying
Fisk, Tamara L.
Sitdhirasdr, Anussorn
Maloney, Susan A.
Dowell, Scott F.
Kosoy, Michael
TI BARTONELLA SEROPREVALENCE IN RURAL THAILAND
SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH
LA English
DT Article
DE Bartonella; seroprevalence; Thailand
ID CAT-SCRATCH DISEASE; SEROLOGICAL CROSS-REACTIONS; HENSELAE;
IDENTIFICATION; PREVALENCE; DIAGNOSIS; DIVERSITY; RODENTS
AB We estimated the prevalence of anti-Bartonella antibodies among febrile and non-febrile patients presenting to community hospitals in rural Thailand from February 2002 through March 2003. Single serum specimens were tested for IgG titers to four Bartonella species, B. henselae, B. quintana, B. elizabethae and B. vinsonii subsp vinsonii using an indirect immunofluorescent assay. A titer >= 1:256 was considered positive. Forty-two febrile patients (9.9%) and 19 non-febrile patients (19%) had positive serology titers to at least one Bartonella species. Age-standardized Bartonella seroprevalence differed significantly between febrile (10%) and non-febrile patients (18%, p = 0.047), but did not differ by gender. Among all 521 patients, IgG titers >= 1:256 to B. henselae were found in 20 participants (3.8%), while 17 (3.3%) had seropositivity to B. quintana, 51(9.8%) to B. elizabethae, and 19 (3.6%) to B. vinsonii subsp vinsonii. These results suggest exposure to Bartonella species is more common in rural Thailand than previously suspected.
C1 [Bhengsri, Saithip] Thailand MOPH, US Ctr Dis Control & Prevent Collaborat, Minist Publ Hlth, IEIP,Dept Dis Control,US CDC Collaborat, Nonthaburi 11000, Thailand.
[Morway, Christina; Bai, Ying; Kosoy, Michael] Ctr Dis Control & Prevent, Ft Collins, CO USA.
[Dowell, Scott F.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Bhengsri, S (reprint author), Thailand MOPH, US Ctr Dis Control & Prevent Collaborat, Minist Publ Hlth, IEIP,Dept Dis Control,US CDC Collaborat, 3rd Floor,Bldg 7, Nonthaburi 11000, Thailand.
EM saithipb@th.cdc.gov
NR 17
TC 7
Z9 9
U1 0
U2 1
PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION
PI BANGKOK
PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND
SN 0125-1562
J9 SE ASIAN J TROP MED
JI Southeast Asian J. Trop. Med. Public Health
PD MAY
PY 2011
VL 42
IS 3
BP 687
EP 692
PG 6
WC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
SC Public, Environmental & Occupational Health; Infectious Diseases;
Tropical Medicine
GA 779IZ
UT WOS:000291772600024
PM 21706948
ER
PT J
AU Schwarz, A
Juarez, JA
Richards, J
Rath, B
Machaca, VQ
Castro, YE
Malaga, ES
Levy, K
Gilman, RH
Bern, C
Verastegui, M
Levy, MZ
AF Schwarz, Alexandra
Ancca Juarez, Jenny
Richards, Jean
Rath, Bruno
Quispe Machaca, Victor
Castro, Yagahira E.
Malaga, Edith S.
Levy, Katelyn
Gilman, Robert H.
Bern, Caryn
Verastegui, Manuela
Levy, Michael Z.
TI Anti-triatomine saliva immunoassays for the evaluation of impregnated
netting trials against Chagas disease transmission
SO INTERNATIONAL JOURNAL FOR PARASITOLOGY
LA English
DT Article
DE Triatoma infestans; Impregnated net; Sentinel guinea pig; Saliva;
Antibody response
ID VECTOR CONTROL; INFESTANS; TRYPANOSOMA; MALARIA; AREQUIPA; PERU
AB Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Quequena, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease. (C) 2011 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Levy, Katelyn; Levy, Michael Z.] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
[Schwarz, Alexandra] Acad Sci Czech Republic, Ctr Biol, Inst Parasitol, Lab Genom & Prote Dis Vectors, Ceske Budjovice, Czech Republic.
[Ancca Juarez, Jenny; Richards, Jean; Rath, Bruno] Univ Peruana Cayetano Heredia, Lab Invest & Desarrollo, Lima, Peru.
[Quispe Machaca, Victor; Castro, Yagahira E.; Malaga, Edith S.; Verastegui, Manuela] Asociac Benef Prisma, Lima, Peru.
[Gilman, Robert H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Bern, Caryn] Ctr Dis Control & Prevent, Div Parasit Dis, Atlanta, GA USA.
RP Levy, MZ (reprint author), Univ Penn, Sch Med, Dept Biostat & Epidemiol, Ctr Clin Epidemiol & Biostat, 819 Blockley Hall,423 Guardian Dr, Philadelphia, PA 19104 USA.
EM mzlevy@mail.med.upenn.edu
FU NIH [5K01 AI079162-03, NIH 3K01AI079162-02S1, 3K01AI079162-03S1, NIH P50
AI074285-04]; UNICEF/UNDP/World Bank/WHO; Grant Agency of the Czech
Republic [P302/11/P798]
FX We thank the community of Quequena for their participation. We
especially thank Rocio Rodriguez, Amparo Toledo and the sprayers and
field collectors who worked on the study. We also thank Gregory Martin,
Jeffrey Stancil, David Bentzel, Ellen Dotson, Robert Wirtz, Lucy Rubio,
Gena Lawrence, Karim Oppe and Fernando Malaga for assistance and
support. The authors thank Torben Frandsen for fabrication and donation
of the guinea pig PermaNets, and Jesus Valenzuela for his advice and
support. We would also like to thank the Pan American Health
Organization (PAHO), the Canadian International Development Agency
(CIDA), Ministerio de Salud del Peril (MINSA), Direccion General de
Salud de las Personas (DGSP), Estrategia Sanitaria Nacional de
Prevencion y Control de Enfermedades Metaxenicas y Otras Transmitidas
por Vectores (ESNPCEMOTVS), Direccion General de Salud Ambiental
(DIGESA), Gobierno Regional de Arequipa and the Gerencia Regional de
Salud de Arequipa (GRSA). Funding for this study came from NIH 5K01
AI079162-03, NIH 3K01AI079162-02S1, 3K01AI079162-03S1 and NIH P50
AI074285-04. This study also received financial support from the
UNICEF/UNDP/World Bank/WHO Special Program for Research and Training in
Tropical Diseases (TDR Grant) and the Grant Agency of the Czech
Republic, Grant No. P302/11/P798.
NR 17
TC 10
Z9 10
U1 2
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-7519
EI 1879-0135
J9 INT J PARASITOL
JI Int. J. Parasit.
PD MAY
PY 2011
VL 41
IS 6
BP 591
EP 594
DI 10.1016/j.ijpara.2011.02.001
PG 4
WC Parasitology
SC Parasitology
GA 774XT
UT WOS:000291420800001
PM 21426907
ER
PT J
AU Bensyl, DM
Vesely, SK
Tolma, EL
Oman, RF
Aspy, C
AF Bensyl, Diana M.
Vesely, Sara K.
Tolma, Eleni L.
Oman, Roy F.
Aspy, Cheryl
TI Associations Between Youth Assets and Sexual Intercourse by Household
Income
SO AMERICAN JOURNAL OF HEALTH PROMOTION
LA English
DT Article
DE Youth Development; Income; Youth Assets; Sexual Intercourse; Prevention
Research
ID RISK BEHAVIORS; FAMILY-STRUCTURE; TRANSMITTED-DISEASES; AMERICAN YOUTH;
AGE; RACE/ETHNICITY; CHILDBEARING; ADOLESCENTS; PREGNANCY; COMMUNITY
AB Purpose. Evaluate youth assets or potential strengths and sexual intercourse associations by household income.
Design. Data consisted of youth and parent responses from randomly selected households from a cross-sectional study and wave one of a longitudinal extension of that study. Youth assets and sexual intercourse were compared for four income categories.
Setting. Midwestern racially diverse, inner-city neighborhoods.
Subjects. One adolescent (12-19 years) and one parent (2335 pairs).
Measures. Adjusted odds ratios (ORs) were calculated using logistic regression. Variables assessed included parent and youth demographics, youth sexual intercourse, and youth assets (adult and peer role models, family communication, use of time [religion or sports], community involvement, future aspirations, responsible choices, and health practices).
Results. Youths' mean age was 14.9 (+/- 1.8) years, and 52% were female; 44% of respondents were white. Use of time (religion) was significantly associated with never having sex for all but the lowest income youth (OR range = 1.79-2.64). The variable peer role models was significant for the lowest income (OR = 2.01) and two upper income groups (ORs = 2.52 and 4.27, respectively). The variable future aspirations was significant for the lowest income youth (OR = 1.77).
Conclusion. The youth asset variable future aspirations was critical for the lowest income households. Other asset variables, such as peer role models and use of time (religion) were critical regardless of income. (Am J Health Promot 2011;25[5]:301-309.)
C1 [Oman, Roy F.] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Hlth Promot Sci, Oklahoma City, OK 73190 USA.
[Bensyl, Diana M.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Oman, RF (reprint author), Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Hlth Promot Sci, POB 26901,CHB Rm 369, Oklahoma City, OK 73190 USA.
EM roy-oman@ouhsc.edu
OI Vesely, Sara/0000-0003-3448-0156
FU NCCDPHP CDC HHS [5 U01DP000132]
NR 37
TC 1
Z9 1
U1 0
U2 6
PU AMER JOURNAL HEALTH PROMOTION INC
PI TROY
PA PO BOX 1254, TROY, MI 48099-1254 USA
SN 0890-1171
J9 AM J HEALTH PROMOT
JI Am. J. Health Promot.
PD MAY-JUN
PY 2011
VL 25
IS 5
BP 301
EP 309
DI 10.4278/ajhp.090401-QUAN-124
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 771SH
UT WOS:000291180500005
PM 21534832
ER
PT J
AU Yu, LL
Verdon, CP
Davis, WC
Turk, GC
Caldwell, KL
Jones, RL
Buckley, B
Xie, RM
AF Yu, Lee L.
Verdon, Carl P.
Davis, W. Clay
Turk, Gregory C.
Caldwell, Kathleen L.
Jones, Robert L.
Buckley, Brian
Xie, Ruimin
TI A human urine standard reference material for accurate assessment of
arsenic exposure
SO ANALYTICAL METHODS
LA English
DT Article
ID HYDRIDE GENERATION; SPECIATION ANALYSIS; HYDROGEN-PEROXIDE; MICROWAVE
SYSTEM; NITRIC-ACID; SPECTROMETRY; PHOTOOXIDATION; CHROMATOGRAPHY;
BEHAVIOR; MS
AB Arsenic is a toxic element, and the toxicity of the element is dependent on its molecular form. Accurate assessments of arsenic exposure require the measurement of a complete panel of inorganic, organic, and metabolite arsenic species in urine, including arsenite (As(III)), arsenate (As(V)), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), trimethylarsine oxide (TMAO), arsenobetaine (AB), and arsenocholine (AC). A certified reference material (CRM) containing the panel of arsenic species in urine is needed for method validation and quality assurance of assessment measurements. Until now, such a CRM was unavailable, due in part to the difficulty in stabilizing arsenic species, especially As(III). For the first time, O(2) in the ambient atmosphere was determined to be the primary cause for the instability of As(III) in an aqueous matrix, and a procedure was developed to stabilize the panel of arsenic species in a dark, low temperature (<-70 degrees C), and oxygen-free environment. Standard Reference Material (R) (SRM) 2669 arsenic species in frozen human urine has been developed to meet the needs in arsenic exposure measurements in general and to support National Health and Nutrition Examination Survey (NHANES), in particular. SRM 2669 is certified for each arsenic species mentioned above at two concentration levels intended to proximate the 50(th) percentile and 95(th) percentile distribution in the US population (concentrations of As(III), As(V), AC, and TMAO in the SRM are adjusted upward of the target percentiles to be above the method detection limits). The SRM was jointly produced by the National Institute of Standards and Technology (NIST) and the Centers for Disease Control and Prevention (CDC). Measurements leading to the certification were made collaboratively at NIST, CDC, and Rutgers, the State University of New Jersey.
C1 [Yu, Lee L.; Davis, W. Clay; Turk, Gregory C.] NIST, Div Analyt Chem, Gaithersburg, MD 20899 USA.
[Verdon, Carl P.; Caldwell, Kathleen L.; Jones, Robert L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Inorgan & Radiat Analyt Toxicol Branch, Atlanta, GA 30341 USA.
[Buckley, Brian; Xie, Ruimin] Rutgers State Univ, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08854 USA.
RP Yu, LL (reprint author), NIST, Div Analyt Chem, Gaithersburg, MD 20899 USA.
RI Yu, Lee/N-7263-2015
OI Yu, Lee/0000-0002-8043-6853
NR 33
TC 5
Z9 5
U1 3
U2 19
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1759-9660
J9 ANAL METHODS-UK
JI Anal. Methods
PD MAY
PY 2011
VL 3
IS 5
BP 1107
EP 1115
DI 10.1039/c0ay00611d
PG 9
WC Chemistry, Analytical; Food Science & Technology; Spectroscopy
SC Chemistry; Food Science & Technology; Spectroscopy
GA 772LS
UT WOS:000291236000013
ER
PT J
AU Stefaniak, AB
Virji, MA
Day, GA
AF Stefaniak, Aleksandr B.
Virji, M. Abbas
Day, Gregory A.
TI Dissolution of beryllium in artificial lung alveolar macrophage
phagolysosomal fluid
SO CHEMOSPHERE
LA English
DT Article
DE Beryllium; Dissolution; Chronic beryllium disease; Lung burden; Immune
diseases
ID IN-VITRO; AEROSOL-PARTICLES; SIMULANT FLUID; DISEASE; OXIDE; METAL;
SENSITIZATION; EXPOSURE; RISK; ALLOY
AB Dissolution of a lung burden of poorly soluble beryllium particles is hypothesized to be necessary for development of chronic beryllium lung disease (CBD) in humans. As such, particle dissolution rate must be sufficient to activate the lung immune response and dissolution lifetime sufficient to maintain chronic inflammation for months to years to support development of disease. The purpose of this research was to investigate the hypothesis that poorly soluble beryllium compounds release ions via dissolution in lung fluid. Dissolution kinetics of 17 poorly soluble particulate beryllium materials that span extraction through ceramics machining (ores, hydroxide, metal, copper-beryllium [CuBe] fume, oxides) and three CuBe alloy reference materials (chips, solid block) were measured over 31 d using artificial lung alveolar macrophage phagolysosomal fluid (pH 4.5). Differences in beryllium-containing particle physicochemical properties translated into differences in dissolution rates and lifetimes in artificial phagolysosomal fluid. Among all materials, dissolution rate constant values ranged from 10(-5) to 10(-10) g cm(-2) d(-1) and half-times ranged from tens to thousands of days. The presence of magnesium trisilicate in some beryllium oxide materials may have slowed dissolution rates. Materials associated with elevated prevalence of CBD had faster beryllium dissolution rates [10(-7)-10(-8) g cm(-2) d(-1)] than materials not associated with elevated prevalence (p < 0.05). Published by Elsevier Ltd.
C1 [Stefaniak, Aleksandr B.; Virji, M. Abbas; Day, Gregory A.] NIOSH, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
RP Stefaniak, AB (reprint author), NIOSH, Ctr Dis Control & Prevent, 1095 Willowdale Rd,Mail Stop H-2703, Morgantown, WV 26505 USA.
EM AStefaniak@cdc.gov; MVirji@cdc.gov; GDay@cdc.gov
RI Stefaniak, Aleksandr/I-3616-2012
FU National Institute for Occupational Safety and Health
FX This work was supported by intramural funding from the National
Institute for Occupational Safety and Health. The funding source had no
role in the study design; data collection, analysis and interpretation;
in the writing of the report; or in the decision to submit this paper
for publication.
NR 42
TC 8
Z9 9
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
J9 CHEMOSPHERE
JI Chemosphere
PD MAY
PY 2011
VL 83
IS 8
BP 1181
EP 1187
DI 10.1016/j.chemosphere.2010.12.088
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 770WY
UT WOS:000291120400018
PM 21251696
ER
PT J
AU Vernet, G
Saha, S
Satzke, C
Burgess, DH
Alderson, M
Maisonneuve, JF
Beall, BW
Steinhoff, MC
Klugman, KP
AF Vernet, G.
Saha, S.
Satzke, C.
Burgess, D. H.
Alderson, M.
Maisonneuve, J. -F.
Beall, B. W.
Steinhoff, M. C.
Klugman, K. P.
TI Laboratory-based diagnosis of pneumococcal pneumonia: state of the art
and unmet needs
SO CLINICAL MICROBIOLOGY AND INFECTION
LA English
DT Article
DE Pneumococcal pneumonia; diagnosis; pneumococci; detection; serotyping
ID COMMUNITY-ACQUIRED PNEUMONIA; DESORPTION IONIZATION-TIME; FLIGHT
MASS-SPECTROMETRY; POLYMERASE-CHAIN-REACTION;
LINKED-IMMUNOSORBENT-ASSAY; URINARY ANTIGEN TEST;
STREPTOCOCCUS-PNEUMONIAE; MULTIPLEX PCR; CONJUGATE VACCINE; ETIOLOGIC
DIAGNOSIS
AB In view of the increasing use of pneumococcal vaccines, especially in the developing world, there is a need for appropriate diagnostics to understand the aetiology of pneumonia, to define the burden of pneumococcal disease, and to monitor vaccine efficacy and effectiveness. This article summarizes a meeting on the diagnosis, detection and serotyping of pneumococcal disease organized by PATH and Fondation Merieux (18-20 October 2009, Fondation Merieux Conference Centre, Les Pensieres, France). Workers and experts met to discuss the gaps in the microbiology-based diagnosis of Streptococcus pneumoniae disease, with special emphasis on pneumonia. The meeting was designed to evaluate the state of the art of pneumococcal diagnostics and serotyping methodologies, identify research and development needs, and propose new guidelines to public health authorities to support the introduction of vaccines. Regarding detection, the main recommendations were to encourage chest X-rays and antigen detection in urine. Large-scale studies are needed to evaluate the diagnostic utility of test algorithms that associate chest X-rays, antigen detection in urine, S. pneumoniae quantitative PCR in nasopharyngeal aspirates and sputum, and C-reactive protein or procalcitonin measurement in blood. Efforts should be focused on proteomics to identify pneumococcus-specific antigens in urine or host markers in blood expressed during pneumonia. It was recommended to develop S. pneumonioe typing capacities, to understand the epidemiology of pneumococcal disease, and to evaluate vaccine effectiveness. Simple and effective approaches are encouraged, and new technologies based on beads, microarrays or deep sequencing should be developed to determine, in a single test capsular serotype, resistance profile and genotype.
C1 [Vernet, G.] Fdn Merieux, F-69007 Lyon, France.
[Saha, S.] Dhaka Shishu Hosp, Child Hlth Res Fdn, Bangladesh Inst Child Hlth, Dept Microbiol, Dhaka, Bangladesh.
[Satzke, C.] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia.
[Satzke, C.] Univ Melbourne, Parkville, Vic 3052, Australia.
[Burgess, D. H.] Bill & Melinda Gates Fdn, Seattle, WA USA.
[Alderson, M.; Maisonneuve, J. -F.] PATH, Seattle, WA USA.
[Beall, B. W.] Ctr Dis Control & Prevent, Resp Dis Branch, Div Bacterial Dis, Atlanta, GA USA.
[Steinhoff, M. C.] Johns Hopkins Med Inst, Baltimore, MD 21205 USA.
[Klugman, K. P.] Univ Witwatersrand, Resp & Meningeal Pathogens Res Unit, Natl Inst Communicable Dis, MRC, Johannesburg, South Africa.
[Klugman, K. P.] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA.
[Klugman, K. P.] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA.
RP Vernet, G (reprint author), Fdn Merieux, 17 Rue Bourgelat, F-69007 Lyon, France.
EM guy.vernet@fondation-merieux.org
RI Satzke, Catherine/D-6501-2013
OI Satzke, Catherine/0000-0003-3164-8849
NR 85
TC 30
Z9 30
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1198-743X
J9 CLIN MICROBIOL INFEC
JI Clin. Microbiol. Infect.
PD MAY
PY 2011
VL 17
SU 3
BP 1
EP 13
PG 13
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA 770YG
UT WOS:000291123800001
PM 21457174
ER
PT J
AU Murashov, V
Schulte, P
Geraci, C
Howard, J
AF Murashov, Vladimir
Schulte, Paul
Geraci, Charles
Howard, John
TI Regulatory Approaches to Worker Protection in Nanotechnology Industry in
the USA and European Union
SO INDUSTRIAL HEALTH
LA English
DT Article
DE Nanotechnology; Nanomaterials; Occupational safety; Regulation; Risk
management; Standards
AB A number of reports have been published regarding the applicability of existing regulatory frameworks to protect consumers and the environment from potentially adverse effects related to introduction of nanomaterials into commerce in the United States and the European Union. However, a detailed comparison of the regulatory approaches to worker safety and health in the USA and in the EU is lacking. This report aims to fill this gap by reviewing regulatory frameworks designed to protect workers and their possible application to nanotechnology.
C1 [Murashov, Vladimir; Howard, John] NIOSH, Washington, DC 20201 USA.
[Schulte, Paul; Geraci, Charles] NIOSH, Cincinnati, OH 45226 USA.
RP Murashov, V (reprint author), NIOSH, 395 E St SW,Suite 9200, Washington, DC 20201 USA.
EM vmurashov@cdc.gov
RI Murashov, Vladimir/K-5481-2012
NR 94
TC 6
Z9 8
U1 2
U2 6
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
J9 IND HEALTH
JI Ind. Health
PD MAY
PY 2011
VL 49
IS 3
SI SI
BP 280
EP 296
DI 10.2486/indhealth.MS1228
PG 17
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 771VU
UT WOS:000291189600004
PM 21372443
ER
PT J
AU Paulozzi, LJ
Weisler, RH
Patkar, AA
AF Paulozzi, Leonard J.
Weisler, Richard H.
Patkar, Ashwin A.
TI A National Epidemic of Unintentional Prescription Opioid Overdose
Deaths: How Physicians Can Help Control It
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Editorial Material
ID CHRONIC PAIN; DISORDERS; ANALGESICS; PREVALENCE; ABUSE
AB Both the usage of prescription drugs such as opioid analgesics and benzodiazepines and overdoses involving them have increased dramatically in the United States since the 1990s. Patients using these drugs often have a combination of painful conditions, substance abuse, and other forms of mental illness. Psychiatrists and many primary care physicians might not be familiar with existing evidence-based guidelines for opioid prescribing or with programs designed to reduce the abuse of prescription drugs such as state prescription drug monitoring programs. Psychiatrists need to be informed regarding this problem to partner effectively with both pain specialists and primary care providers in their community. J Clin Psychiatry 2011;72(5):589-592 (C) Copyright 2011 Physicians Postgraduate Press, Inc.
C1 [Paulozzi, Leonard J.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA.
[Weisler, Richard H.; Patkar, Ashwin A.] Duke Univ, Sch Med, Dept Psychiat & Behav Sci, Durham, NC USA.
[Weisler, Richard H.] Univ N Carolina, Chapel Hill Sch Med, Dept Psychiat, Chapel Hill, NC 27515 USA.
RP Paulozzi, LJ (reprint author), 601 Sunland Pk Dr,Ste 200, El Paso, TX 79912 USA.
EM lbp4@cdc.gov
NR 23
TC 55
Z9 55
U1 0
U2 3
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 240008, MEMPHIS, TN 38124 USA
SN 0160-6689
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAY
PY 2011
VL 72
IS 5
BP 589
EP 592
DI 10.4088/JCP.10com06560
PG 4
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA 772NM
UT WOS:000291240600003
PM 21536000
ER
PT J
AU Nakata, A
AF Nakata, Akinori
TI Work Hours, Sleep Sufficiency, and Prevalence of Depression Among
Full-Time Employees: A Community-Based Cross-Sectional Study
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID JAPANESE MALE WORKERS; OVERTIME WORK; JOB STRESS; PHYSICAL FATIGUE;
UNITED-STATES; HEALTH; SYMPTOMS; DURATION; DISTURBANCES; INSOMNIA
AB Objective: Depression due to long work hours and sleep deprivation is a major occupational health concern. The extent to which work hours and sleep are associated with depression was investigated in employees of small- and medium-scale businesses in the Japanese city of Yashio, Saitama, and in the Ohta ward of Tokyo, a suburb of Tokyo, controlling for various potential confounders.
Method: In this cross-sectional study, a total of 2,643 full-time employees (1,928 men and 715 women), aged 18-79 years (mean=45 years), in 296 small- and medium-scale businesses were surveyed from August 2002 to December 2002 using a self-administered questionnaire evaluating work hours, sleep status, and covariates including socio-demographic and socioeconomic factors, health behaviors, biological factors, medication usage, and occupational factors. Depression was assessed using the Center for Epidemiologic Studies Depression Scale. Prevalence of depression by work hours, sleep status, and covariates was analyzed by chi(2) test. Risk of depression by work hours, sleep status, and both combined was estimated by milltivariate logistic regression analysis.
Results: Participants working >10 hours per day, sleeping <6 hours per day, and reporting insufficient sleep were, respectively, 37%, 43%, and 97% more likely to be depressed than those working 6 to 8 hours per day, sleeping 6 to <8 hours per day, and reporting sufficient sleep (P < .05). Participants working >10 hours per day or >8 to 10 hours per day with <6 hours per day of sleep showed a 41%-169% higher prevalence of depression versus those working 6 to 8 hours per day with 6+ hours per day of sleep (P <. 05). Participants reporting insufficient sleep in 3 work-hour categories (6 to 8, >8 to 10, and >10 hours per day) showed a 62%-179% increase in the prevalence of depression versus those working 6 to 8 hours per day and reporting sufficient sleep (P <. 05). No significant effects on depression were found for subjects in any work-hour category with 6+ hours of sleep or with subjective sufficient sleep.
Conclusions: Depression associated with long work hours is primarily a result of sleep deprivation. Greater attention should be paid to management of sleep deprivation to prevent workplace depression. J Clin Psychiatry 2011;72(5):605-614 (C) Copyright 2011 Physicians Postgraduate Press, Inc.
C1 NIOSH, Div Appl Res & Technol, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA.
RP Nakata, A (reprint author), NIOSH, Div Appl Res & Technol, Ctr Dis Control & Prevent, MS C24,4676 Columbia Pkwy, Cincinnati, OH 45226 USA.
EM cji5@cdc.gov
FU Japan National Institute of Occupational Safety and Health, Kawasaki,
Japan
FX This research was partly supported by the base funding of the Japan
National Institute of Occupational Safety and Health, Kawasaki, Japan.
NR 42
TC 25
Z9 25
U1 3
U2 27
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 240008, MEMPHIS, TN 38124 USA
SN 0160-6689
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAY
PY 2011
VL 72
IS 5
BP 605
EP 614
DI 10.4088/JCP.10m06397gry
PG 10
WC Psychology, Clinical; Psychiatry
SC Psychology; Psychiatry
GA 772NM
UT WOS:000291240600006
PM 21658347
ER
PT J
AU Madoff, LC
Fisman, DN
Kass-Hout, T
AF Madoff, Lawrence C.
Fisman, David N.
Kass-Hout, Taha
TI A New Approach to Monitoring Dengue Activity
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Editorial Material
ID PUBLIC-HEALTH; DISEASE DETECTION; SURVEILLANCE; VIRUS; FEVER;
INFECTIONS; EMERGENCE; EPIDEMIC; SPREAD; WEB
C1 [Madoff, Lawrence C.] Univ Massachusetts, Med Ctr, Div Infect Dis & Immunol, Worcester, MA 01609 USA.
[Madoff, Lawrence C.] Massachusetts Dept Publ Hlth, Div Epidemiol & Immunizat, Boston, MA USA.
[Fisman, David N.] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
[Fisman, David N.] Univ Toronto, Dept Hlth Policy, Toronto, ON, Canada.
[Fisman, David N.] Univ Toronto, Dept Management, Toronto, ON, Canada.
[Fisman, David N.] Univ Toronto, Dept Evaluat, Toronto, ON, Canada.
[Fisman, David N.] Univ Toronto, Dept Med, Toronto, ON, Canada.
[Kass-Hout, Taha] US Ctr Dis Control & Prevent, Publ Hlth Surveillance Program Off, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA USA.
RP Madoff, LC (reprint author), Univ Massachusetts, Med Ctr, Div Infect Dis & Immunol, Worcester, MA 01609 USA.
EM david.fisman@utoronto.ca
OI Kass-Hout, Taha/0000-0002-0123-5157
NR 28
TC 12
Z9 13
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2727
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD MAY
PY 2011
VL 5
IS 5
AR e1215
DI 10.1371/journal.pntd.0001215
PG 5
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 770OZ
UT WOS:000291099100049
PM 21647309
ER
PT J
AU Moro, PL
Budke, CM
Schantz, PM
Vasquez, J
Santivanez, SJ
Villavicencio, J
AF Moro, Pedro L.
Budke, Christine M.
Schantz, Peter M.
Vasquez, Julio
Santivanez, Saul J.
Villavicencio, Jaime
TI Economic Impact of Cystic Echinococcosis in Peru
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID GRANULOSUS INFECTION; DEVELOPING-COUNTRY; TIBETAN PLATEAU; ENDEMIC
REGION; DIAGNOSIS; FOCUS
AB Background: Cystic echinococcosis (CE) constitutes an important public health problem in Peru. However, no studies have attempted to estimate the monetary and non-monetary impact of CE in Peruvian society.
Methods: We used official and published sources of epidemiological and economic information to estimate direct and indirect costs associated with livestock production losses and human disease in addition to surgical CE-associated disability adjusted life years (DALYs) lost.
Findings: The total estimated cost of human CE in Peru was U. S.$ 2,420,348 (95% CI: 1,118,384-4,812,722) per year. Total estimated livestock-associated costs due to CE ranged from U. S.$ 196,681 (95% CI: 141,641-251,629) if only direct losses (i.e., cattle and sheep liver destruction) were taken into consideration to U. S.$ 3,846,754 (95% CI: 2,676,181-4,911,383) if additional production losses (liver condemnation, decreased carcass weight, wool losses, decreased milk production) were accounted for. An estimated 1,139 (95% CI: 861-1,489) DALYs were also lost due to surgical cases of CE.
Conclusions: This preliminary and conservative assessment of the socio-economic impact of CE on Peru, which is based largely on official sources of information, very likely underestimates the true extent of the problem. Nevertheless, these estimates illustrate the negative economic impact of CE in Peru.
C1 [Moro, Pedro L.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Immunizat Safety Off, Atlanta, GA 30333 USA.
[Budke, Christine M.] Texas A&M Univ, Coll Vet Med & Biomed Sci, College Stn, TX USA.
[Schantz, Peter M.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
[Vasquez, Julio] Portneuf Med Ctr, Pocatello, ID USA.
[Vasquez, Julio] Idaho State Univ, Pocatello, ID 83209 USA.
[Santivanez, Saul J.] Inst Peruano Parasitol Clin & Expt, Lima, Peru.
[Villavicencio, Jaime] Minist Agr, Serv Nacl Sanidad Agr, Lima, Peru.
RP Moro, PL (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Immunizat Safety Off, Atlanta, GA 30333 USA.
EM pmoro@cdc.gov
NR 27
TC 11
Z9 12
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2727
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD MAY
PY 2011
VL 5
IS 5
AR e1179
DI 10.1371/journal.pntd.0001179
PG 6
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 770OZ
UT WOS:000291099100042
PM 21629731
ER
PT J
AU Reis, C
Cote, M
Le Rhun, D
Lecuelle, B
Levin, ML
Vayssier-Taussat, M
Bonnet, SI
AF Reis, Caroline
Cote, Martine
Le Rhun, Danielle
Lecuelle, Benoit
Levin, Michael L.
Vayssier-Taussat, Muriel
Bonnet, Sarah I.
TI Vector Competence of the Tick Ixodes ricinus for Transmission of
Bartonella birtlesii
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID HENSELAE; INFECTION; DOGS; MICE; EMERGENCE; PREVALENT; AGENT; FEVER;
MODEL; FLEA
AB Bartonella spp. are facultative intracellular vector-borne bacteria associated with several emerging diseases in humans and animals all over the world. The potential for involvement of ticks in transmission of Bartonella spp. has been heartily debated for many years. However, most of the data supporting bartonellae transmission by ticks come from molecular and serological epidemiological surveys in humans and animals providing only indirect evidences without a direct proof of tick vector competence for transmission of bartonellae. We used a murine model to assess the vector competence of Ixodes ricinus for Bartonella birtlesii. Larval and nymphal I. ricinus were fed on a B. birtlesii-infected mouse. The nymphs successfully transmitted B. birtlesii to naive mice as bacteria were recovered from both the mouse blood and liver at seven and 16 days after tick bites. The female adults successfully emitted the bacteria into uninfected blood after three or more days of tick attachment, when fed via membrane feeding system. Histochemical staining showed the presence of bacteria in salivary glands and muscle tissues of partially engorged adult ticks, which had molted from the infected nymphs. These results confirm the vector competence of I. ricinus for B. birtlesii and represent the first in vivo demonstration of a Bartonella sp. transmission by ticks. Consequently, bartonelloses should be now included in the differential diagnosis for patients exposed to tick bites.
C1 [Reis, Caroline; Cote, Martine; Le Rhun, Danielle; Vayssier-Taussat, Muriel; Bonnet, Sarah I.] ANSES, USC INRA Bartonella Tiques, Inst Natl Rech Agron, Maisons Alfort, France.
[Lecuelle, Benoit] Ecole Natl Vet Alfort, Ctr Rech Biomed, Maisons Alfort, France.
[Levin, Michael L.] Ctr Dis Control & Prevent, Med Entomol Lab, Atlanta, GA USA.
RP Reis, C (reprint author), ANSES, USC INRA Bartonella Tiques, Inst Natl Rech Agron, Maisons Alfort, France.
EM sbonnet@vet-alfort.fr
RI Bonnet, Sarah/E-2636-2012
FU INRA; CIRAD institutes; Region Ile de France
FX This work was supported by research funds from INRA and CIRAD institutes
and by the Region Ile de France. The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 31
TC 45
Z9 45
U1 1
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD MAY
PY 2011
VL 5
IS 5
AR e1186
DI 10.1371/journal.pntd.0001186
PG 6
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 770OZ
UT WOS:000291099100045
PM 21655306
ER
PT J
AU Sak, B
Kvac, M
Kucerova, Z
Kvetonova, D
Sakova, K
AF Sak, Bohumil
Kvac, Martin
Kucerova, Zuzana
Kvetonova, Dana
Sakova, Kamila
TI Latent Microsporidial Infection in Immunocompetent Individuals - A
Longitudinal Study
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID ENCEPHALITOZOON-CUNICULI INFECTION; ENTEROCYTOZOON-BIENEUSI; INTESTINAL
MICROSPORIDIOSIS; SPECIES DETERMINATION; TRANSPLANT RECIPIENT; PCR
AMPLIFICATION; STOOL SPECIMENS; DIARRHEA; PREVALENCE; TRAVELERS
AB Background: Microsporidia (Fungi) have been repeatedly identified as the cause of opportunistic infections predominantly in immunodeficient individuals such as AIDS patients. However, the global epidemiology of human microsporidiosis is poorly understood and the ability of microsporidia to survive and multiply in immunocompetent hosts remains unsolved.
Aims: To determine the presence of latent microsporidia infections in apparently healthy humans in the Czech Republic, the authors tested sera, urine and stool originating from fifteen persons within a three month period examined on a weekly basis.
Methods: Sera, stool and urine samples originating from fifteen HIV-negative people at risk with occupational exposure to animals, aged 22-56 years, living in the Czech Republic were tested by indirect immunofluorescence assay (IFA) for the presence of specific anti-microsporidial antibodies, standard Calcofluor M2R staining for the detection of microsporidian spores in all urine sediments and stool smears and molecular methods for the microsporidial species determination.
Results: Specific anti-microsporidial antibodies were detected in fourteen individuals, asymptomatic Encephalitozoon spp. infection was found in thirteen and E. bieneusi infection was detected in seven of those examined. While E. hellem 1A and E. cuniculi II were the major causative agents identified, seven different genotypes of E. bieneusi were recorded.
Conclusions: These findings clearly show that exposure to microsporidia is common and chronic microsporidiosis is not linked to any clinical manifestation in healthy population. Moreover, our results indicate much higher incidence of microsporidial infections among an apparently healthy population than previously reported. These results open the question about the potential risk of reactivation of latent microsporidiosis in cases of immunosupression causing life-threatening disease.
C1 [Sak, Bohumil; Kvac, Martin; Kvetonova, Dana] Acad Sci Czech Republic, Inst Parasitol, Ctr Biol, VVI, CR-37005 Ceske Budejovice, Czech Republic.
[Kvac, Martin] Univ S Bohemia Ceske Budejovice, Fac Agr, Ceske Budejovice, Czech Republic.
[Kucerova, Zuzana] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Sakova, Kamila] Ceske Budejovice Hosp, Virol Lab, Ceske Budejovice, Czech Republic.
RP Sak, B (reprint author), Acad Sci Czech Republic, Inst Parasitol, Ctr Biol, VVI, Branisovska 31, CR-37005 Ceske Budejovice, Czech Republic.
EM kvac@paru.cas.cz
RI Kvac, Martin/G-7299-2014; Sak, Bohumil/G-9262-2014
OI Kvac, Martin/0000-0003-0013-6090;
FU Academy of Sciences of the Czech Republic [KJB500960701]; Grant Agency
of the Czech Republic [523/07/P117]; Institute of Parasitology, Academy
of Sciences of the Czech Republic [Z60220518]; National Institute of
Allergy and Infectious Diseases [R13AI078718]
FX This study was funded by a grant from the Academy of Sciences of the
Czech Republic (KJB500960701), the Grant Agency of the Czech Republic
(project No. 523/07/P117), research project of the Institute of
Parasitology, Academy of Sciences of the Czech Republic (Z60220518) and
in part by NIH grant R13AI078718 from the National Institute of Allergy
and Infectious Diseases. The funders had no role in study design, data
collection and analyses, decision to publish, or preparation of the
manuscript.
NR 27
TC 42
Z9 43
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2727
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD MAY
PY 2011
VL 5
IS 5
AR e1162
DI 10.1371/journal.pntd.0001162
PG 5
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 770OZ
UT WOS:000291099100032
PM 21629721
ER
PT J
AU Foy, BD
Kobylinski, KC
Foy, JLC
Blitvich, BJ
da Rosa, AT
Haddow, AD
Lanciotti, RS
Tesh, RB
AF Foy, Brian D.
Kobylinski, Kevin C.
Foy, Joy L. Chilson
Blitvich, Bradley J.
da Rosa, Amelia Travassos
Haddow, Andrew D.
Lanciotti, Robert S.
Tesh, Robert B.
TI Probable Non-Vector-borne Transmission of Zika Virus, Colorado, USA
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID MICRONESIA; HAMSTERS; FEVER
AB Clinical and serologic evidence indicate that 2 American scientists contracted Zika virus infections while working in Senegal in 2008. One of the scientists transmitted this arbovirus to his wife after his return home. Direct contact is implicated as the transmission route, most likely as a sexually transmitted infection.
C1 [Foy, Brian D.] Colorado State Univ, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA.
[Foy, Joy L. Chilson] Poudre Valley Hosp, Ft Collins, CO USA.
[Blitvich, Bradley J.] Iowa State Univ, Ames, IA USA.
[da Rosa, Amelia Travassos; Haddow, Andrew D.; Tesh, Robert B.] Univ Texas Med Branch, Galveston, TX USA.
[Lanciotti, Robert S.] Ctr Dis Control & Prevent, Ft Collins, CO USA.
RP Foy, BD (reprint author), Colorado State Univ, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA.
EM brian.foy@colostate.edu
RI Foy, Brian/E-6230-2017; Franco-Hurtado, Fernando/E-5599-2017;
OI Foy, Brian/0000-0002-9117-203X; Franco-Hurtado,
Fernando/0000-0001-5775-0150; Haddow, Andrew/0000-0002-8957-2608
FU US National Institutes of Allergy and Infectious Diseases [AI079528,
N01-AI-25489]
FX This study was supported by grant AI079528 and contract N01-AI-25489
from the US National Institutes of Allergy and Infectious Diseases.
NR 15
TC 264
Z9 286
U1 54
U2 190
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD MAY
PY 2011
VL 17
IS 5
BP 880
EP 882
DI 10.3201/eid1705.101939
PG 3
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 760AB
UT WOS:000290291900020
PM 21529401
ER
PT J
AU Johnson, KM
Antczak, DF
Dietz, WH
Martin, DH
Walton, TE
AF Johnson, Karl M.
Antczak, Douglas F.
Dietz, William H.
Martin, David H.
Walton, Thomas E.
TI The Crab Hole Mosquito Blues
SO EMERGING INFECTIOUS DISEASES
LA English
DT Article
ID VENEZUELAN EQUINE ENCEPHALOMYELITIS; ENCEPHALITIS-VIRUS; EXPERIMENTAL
INFECTION; CENTRAL-AMERICA; HORSES; PANAMA
AB Venezuelan equine encephalomyelitis (VEE) epizoodemics were reported at 6-10-year intervals in northern South America beginning in the 1920s. In 1937, epizootic VEE virus was isolated from infected horse brain and shown as distinct from the North American equine encephalomyelitis viruses. Subsequently, epizootic and sylvatic strains were isolated in distinct ecosystems; isolates were characterized serologically as epizootic subtype I, variants A/B and C; or sylvatic (enzootic) subtype I, variants D, E, and F, and subtypes II, III, and IV. In 1969, variant I-A/B virus was transported from a major outbreak in northern South America to the borders of El Salvador, Guatemala, and Honduras. This musical poem describes the history and ecology of VEE viruses and the epidemiology of an unprecedented 1969 movement of VEE viruses from South America to equids and humans in Central America from Costa Rica to Guatemala and Belize and in Mexico and the United States that continued until 1972.
C1 [Antczak, Douglas F.] Cornell Univ, Ithaca, NY USA.
[Dietz, William H.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Martin, David H.] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA.
RP Walton, TE (reprint author), 5365 N Scottsdale Rd, Eloy, AZ 85131 USA.
EM tewalton@q.com
NR 19
TC 0
Z9 0
U1 1
U2 8
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD MAY
PY 2011
VL 17
IS 5
BP 923
EP 927
DI 10.3201/eid1705.101412
PG 5
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 760AB
UT WOS:000290291900033
PM 21529414
ER
PT J
AU Mahdi, M
Erickson, BR
Comer, JA
Nichol, ST
Rollin, PE
AlMazroa, MA
Memish, ZA
AF Mahdi, Mustafa
Erickson, Bobbie Rae
Comer, J. Andy
Nichol, Stuart T.
Rollin, Pierre E.
AlMazroa, Mohammed A.
Memish, Ziad A.
TI Kyasanur Forest Disease Virus Alkhurma Subtype in Ticks, Najran
Province, Saudi Arabia
SO EMERGING INFECTIOUS DISEASES
LA English
DT Letter
ID HEMORRHAGIC-FEVER
C1 [Erickson, Bobbie Rae; Comer, J. Andy; Nichol, Stuart T.; Rollin, Pierre E.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Mahdi, Mustafa] Najran Prevent Med Dept, Najran, Saudi Arabia.
[AlMazroa, Mohammed A.; Memish, Ziad A.] Minist Hlth, Riyadh, Saudi Arabia.
RP Rollin, PE (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G14, Atlanta, GA 30333 USA.
EM pyr3@cdc.gov
NR 10
TC 15
Z9 15
U1 0
U2 2
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD MAY
PY 2011
VL 17
IS 5
BP 945
EP 947
DI 10.3201/eid1705.101824
PG 3
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 760AB
UT WOS:000290291900044
PM 21529425
ER
PT J
AU Smith, SG
Basile, KC
Karch, D
AF Smith, Sharon G.
Basile, Kathleen C.
Karch, Debra
TI Sexual Homicide and Sexual Violence-Associated Homicide: Findings From
the National Violent Death Reporting System
SO HOMICIDE STUDIES
LA English
DT Article
DE sexual homicide; sexual violence; NVDRS
ID MURDER; STATES; CLASSIFICATION; VICTIMIZATION; MOTIVATION
AB Sexual violence is linked to homicide in a variety of ways. In this study the authors analyzed narratives that described the homicide circumstances of 285 homicide victims from 17 states who participated in the National Violent Death Reporting System during 2003-2007. The authors discuss a narrative analysis conducted using qualitative methods that revealed four categories of homicide linked to sexual violence, in addition to classic sexual homicide. In this article, the authors provide descriptions of the circumstances involved in sexual violence-related homicides, narrative examples of each type, and offer an expanded classification of these crimes. The analyses reveal specific types of homicide that are related to the perpetration of sexual violence, some of which have received little to no attention in the sexual violence or homicide literature. The study demonstrates the potential of the NVDRS as a strong data source for sexual homicides as well as other forms of homicide. Finally, the authors discuss implications for ongoing monitoring of homicides that are linked to sexual violence.
C1 [Smith, Sharon G.; Basile, Kathleen C.; Karch, Debra] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
RP Smith, SG (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE,Mailstop F-64, Atlanta, GA 30341 USA.
EM SSmith4@cdc.gov
NR 35
TC 7
Z9 7
U1 0
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1088-7679
J9 HOMICIDE STUD
JI Homicide Stud.
PD MAY
PY 2011
VL 15
IS 2
BP 132
EP 153
DI 10.1177/1088767911406236
PG 22
WC Criminology & Penology
SC Criminology & Penology
GA 768TF
UT WOS:000290960600002
ER
PT J
AU Wen, XJ
Balluz, LS
AF Wen, Xiao Jun
Balluz, Lina S.
TI Physical Activity Level and Ischemic Heart Disease Prevalence Among
Individuals Aged 45 Years and Older With Normal Weight, BRFSS, 2007
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Article
DE Behavioral Risk Factor Surveillance System; BMI; coronary heart disease;
CHD; LHD; risk behavior
ID RISK-FACTOR SURVEILLANCE; PREVENTION; OBESITY; CHD; ASSOCIATION;
VALIDITY; HEALTH; DEATH; MEN; NUTRITION
AB Background: Most ischemic heart disease (IHD) prevention programs that promote physical activity (PA) have focused on overweight/obese populations. Persons with normal body mass index (BMI) may mistakenly think that they are not at risk for IHD and remain physically inactive. Studies exploring the risk of IHD and PA level among adults aged 45 years and older with normal weight are limited. Methods: Cross-sectional study to examine the prevalence of IHD and PA level among 94455 respondents aged 45 years and older with normal BMI using the 2007 Behavioral Risk Factor Surveillance System data. Results: Approximately 50% of respondents reported low/inactive PA. The prevalence of IHD among persons with inactive, low, medium, and high PA was 16.6% (95% CI = 15.1-18.1%), 9.6% (8.9-10.3%), 8.9% (8.3-9.6%), and 5.4% (4.9-5.9%). The adjusted odds ratios of IHD among persons with low, medium, and high PA compared with those with inactive PA was 0.68 (95% CI = 0.59-0.79), 0.63 (0.54-0.73), and 0.49 (0.42-0.57). Conclusions: The percentage of respondents with low or inactive PA among populations aged 45 years and older with BMI 18 to <25 was alarmingly high and independently associated with higher IHD prevalence. Persons who are not overweight/obese still need to have adequate PA to reduce the risk of IHD.
C1 [Wen, Xiao Jun] Ctr Dis Control & Prevent, Behav & Clin Surveillance Branch, Div HIV AIDS Prevent, Atlanta, GA USA.
[Balluz, Lina S.] Ctr Dis Control & Prevent, Div Behav Surveillance, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA USA.
RP Wen, XJ (reprint author), Ctr Dis Control & Prevent, Behav & Clin Surveillance Branch, Div HIV AIDS Prevent, Atlanta, GA USA.
NR 35
TC 1
Z9 1
U1 0
U2 0
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD MAY
PY 2011
VL 8
IS 4
BP 475
EP 480
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 768YD
UT WOS:000290974900003
PM 21597119
ER
PT J
AU Bardenheier, BH
Shefer, AM
Rodewald, L
Ahmed, F
Gravenstein, S
Remsburg, RE
AF Bardenheier, Barbara H.
Shefer, Abigail M.
Rodewald, Lance
Ahmed, Faruque
Gravenstein, Stefan
Remsburg, Robin E.
TI In Reply: Influenza Vaccination in Long-Term Care Facilities: More Than
Standing Order Programs?
SO JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
LA English
DT Letter
ID STATES
C1 [Bardenheier, Barbara H.; Shefer, Abigail M.; Rodewald, Lance; Ahmed, Faruque] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Gravenstein, Stefan] Brown Univ, Providence, RI 02912 USA.
[Remsburg, Robin E.] George Mason Univ, Fairfax, VA 22030 USA.
RP Bardenheier, BH (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
NR 6
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1525-8610
J9 J AM MED DIR ASSOC
JI J. Am. Med. Dir. Assoc.
PD MAY
PY 2011
VL 12
IS 4
BP 316
EP 317
DI 10.1016/j.jamda.2011.01.011
PG 2
WC Geriatrics & Gerontology
SC Geriatrics & Gerontology
GA 768HK
UT WOS:000290924500017
ER
PT J
AU Hall, T
Krahn, GL
Horner-Johnson, W
Lamb, G
AF Hall, Trevor
Krahn, Gloria L.
Horner-Johnson, Willi
Lamb, Gordon
TI Examining Functional Content in Widely Used Health-Related Quality of
Life Scales
SO REHABILITATION PSYCHOLOGY
LA English
DT Article
DE health-related quality of life; health status; disability; function;
bias; measurement
ID PERCEIVED HEALTH; OLDER-ADULTS; DISABILITY; OUTCOMES; SUPPORT; INJURY;
SF-36
AB Purpose: Assess extent to which generic Quality of Life (QOL) and Health-Related Quality of Life (HRQOL) scales include function in assessment of health, and identify health assessment items that are free of functional content. Methods: An expert panel on measurement of health and disability reached consensus on definitions of health, disability, and function. They assessed all items of all generic (non-condition-specific) scales in the 2006 ProQolid database for being important to measuring health as distinct from function. Ratings were summarized as content validity ratios. Retained items were written into standard format and reviewed again by the expert panel and a validity panel with expertise in specific disabilities. Results: Of 85 scales, 21 were retained as containing items important for assessing health. Scales ranged from 100% (BRFSS HRQOL, WHO-5) to only 4% of items rated as important. In further review of "important" items, functional content was identified in many of the items, particularly with regard to mental functioning. Conclusions: Popular generic scales of QOL and HRQOL vary greatly in the degree to which they include content on function. A pool of items can be identified that are relatively free of function. Distinguishing measurement of function and health is particularly important for people with long-standing functional limitations and for assessing the relationship of health with function.
C1 [Horner-Johnson, Willi] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Portland, OR 97207 USA.
[Lamb, Gordon] Sam Houston State Univ, Dept Psychol, Houston, TX USA.
[Krahn, Gloria L.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Hall, Trevor] Oregon Hlth & Sci Univ, Child Dev & Rehabil Ctr, Portland, OR 97207 USA.
RP Horner-Johnson, W (reprint author), Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, POB 574, Portland, OR 97207 USA.
EM hornerjo@ohsu.edu
OI Horner-Johnson, Willi/0000-0003-3568-1400
NR 24
TC 16
Z9 15
U1 1
U2 5
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 0090-5550
EI 1939-1544
J9 REHABIL PSYCHOL
JI Rehabil. Psychol.
PD MAY
PY 2011
VL 56
IS 2
BP 94
EP 99
DI 10.1037/a0023054
PG 6
WC Psychology, Clinical; Rehabilitation
SC Psychology; Rehabilitation
GA 769KL
UT WOS:000291011800002
PM 21574727
ER
PT J
AU Rasmussen, SA
AF Rasmussen, S. A.
TI Human Teratogens Update 2011
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Rasmussen, S. A.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2011
VL 91
IS 5
SI SI
BP 306
EP 306
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 762QQ
UT WOS:000290494900003
ER
PT J
AU Lin, S
Kielb, CL
Herdt-Losavio, ML
Bell, EM
Chapman, BR
Rocheleau, CM
Waters, MA
Lawton, CC
Stewart, PA
Romitti, PA
Druschel, CM
AF Lin, S.
Kielb, C. L.
Herdt-Losavio, M. L.
Bell, E. M.
Chapman, B. R.
Rocheleau, C. M.
Waters, M. A.
Lawton, C. C.
Stewart, P. A.
Romitti, P. A.
Druschel, C. M.
TI Maternal Occupational Exposure to Pesticides and the Risk of
Musculoskeletal Birth Defects: A Preliminary Analysis
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Lin, S.; Kielb, C. L.; Herdt-Losavio, M. L.; Druschel, C. M.] NYS Dept Hlth, Troy, NY USA.
[Bell, E. M.] SUNY Albany, Rensselaer, NY USA.
[Chapman, B. R.] Upstate Med Univ SUNY, Syracuse, NY USA.
[Rocheleau, C. M.; Waters, M. A.; Lawton, C. C.] NIOSH, Cincinnati, OH 45226 USA.
[Stewart, P. A.] Stewan Exposure Assessments LLC, Arlington, VA USA.
[Romitti, P. A.] Univ Iowa, Iowa City, IA USA.
NR 0
TC 0
Z9 0
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2011
VL 91
IS 5
SI SI
BP 351
EP 351
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 762QQ
UT WOS:000290494900081
ER
PT J
AU Zhang, P
Zhang, XZ
Brown, J
Vistisen, D
Sicree, R
Shaw, J
Nichols, G
AF Zhang, Ping
Zhang, Xinzhi
Brown, Jonathan
Vistisen, Dorte
Sicree, Richard
Shaw, Jonathan
Nichols, Gregory
TI Global healthcare expenditure on diabetes for 2010 and 2030 (vol 87, pg
293, 2010)
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Correction
C1 [Zhang, Ping; Zhang, Xinzhi] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA.
[Brown, Jonathan; Nichols, Gregory] Kaiser Permanente, Ctr Hlth Res, Portland, OR USA.
[Vistisen, Dorte] Steno Diabet Ctr NS, DK-2820 Gentofte, Denmark.
[Sicree, Richard; Shaw, Jonathan] Baker IDI Heart & Diabet Inst, Caulfield, Vic 3162, Australia.
RP Zhang, P (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, Mailstop K-10,4770 Buford Highway NE, Atlanta, GA USA.
NR 2
TC 4
Z9 4
U1 2
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0168-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD MAY
PY 2011
VL 92
IS 2
BP 301
EP 301
DI 10.1016/j.diabres.2010.12.025
PG 1
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 764ER
UT WOS:000290612200027
ER
PT J
AU Thurman, KA
Warner, AK
Cowart, KC
Benitez, AJ
Winchell, JM
AF Thurman, Kathleen A.
Warner, Agnes K.
Cowart, Kelley C.
Benitez, Alvaro J.
Winchell, Jonas M.
TI Detection of Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella
spp. in clinical specimens using a single-tube multiplex real-time PCR
assay
SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
LA English
DT Article
DE Real-time PCR; Multiplex real-time PCR; Community-acquired pneumonia
ID COMMUNITY-ACQUIRED PNEUMONIA; CHAIN-REACTION ASSAY;
CHLAMYDOPHILA-PNEUMONIAE; RESPIRATORY SPECIMENS; DIAGNOSIS; PNEUMOPHILA;
INFECTION; DISEASE; ADULTS; PREVENTION
AB A multiplex real-time PCR assay for the detection of Mycoplasma pneumoniae (MP181), Chlamydia (Chlamydophila) pneumoniae (CP-Arg), Legionella spp. (Pan-Leg), and the human RNase P (RNase P) gene was developed for rapid testing of atypical bacterial respiratory pathogens in clinical specimens. This method uses 4 distinct hydrolysis probes to detect 3 leading causes of community-acquired pneumonia. The assay was evaluated for specificity and sensitivity by testing against 35 related organisms, a dilution series of each specific target and 197 clinical specimens. Specificity testing demonstrated no cross-reactivity. A comparison to previously validated singleplex real-time PCR assays for each agent was also performed. The analytical sensitivity for specific pathogen targets in both the singleplex and multiplex was identical (50 fg), while efficiencies ranged from 82% to 97% for the singleplex assays and from 90% to 100% for the multiplex assay. The clinical sensitivity of the multiplex assay was improved for the Pan-Leg and CP-Arg targets when compared to the singleplex. The MP181 assay displayed equivalent performance. This multiplex assay provides an overall improvement in the diagnostic capability for these agents by demonstrating a sensitive, high-throughput and rapid method. This procedure may allow for a practical and efficient means to test respiratory clinical specimens for atypical pneumonia agents in health care settings and facilitate an appropriate public health response to outbreaks. Published by Elsevier Inc.
C1 [Thurman, Kathleen A.; Warner, Agnes K.; Cowart, Kelley C.; Benitez, Alvaro J.; Winchell, Jonas M.] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30333 USA.
RP Winchell, JM (reprint author), Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30333 USA.
EM jwinchell@cdc.gov
NR 31
TC 49
Z9 52
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0732-8893
J9 DIAGN MICR INFEC DIS
JI Diagn. Microbiol. Infect. Dis.
PD MAY
PY 2011
VL 70
IS 1
BP 1
EP 9
DI 10.1016/j.diagmicrobio.2010.11.014
PG 9
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA 759ZN
UT WOS:000290290500001
PM 21397428
ER
PT J
AU Milstein, B
Homer, J
Briss, P
Burton, D
Pechacek, T
AF Milstein, Bobby
Homer, Jack
Briss, Peter
Burton, Deron
Pechacek, Terry
TI Why Behavioral And Environmental Interventions Are Needed To Improve
Health At Lower Cost
SO HEALTH AFFAIRS
LA English
DT Article
ID PARTICULATE AIR-POLLUTION; PUBLIC-HEALTH; UNITED-STATES; CARDIOVASCULAR
MORTALITY; CARE; DISEASE; PREVENTION; QUALITY; REFORM; IMPACT
AB We used a dynamic simulation model of the US health system to test three proposed strategies to reduce deaths and improve the cost-effectiveness of interventions: expanding health insurance coverage, delivering better preventive and chronic care, and protecting health by enabling healthier behavior and improving environmental conditions. We found that each alone could save lives and provide good economic value, but they are likely to be more effective in combination. Although coverage and care save lives quickly, they tend to increase costs. The impact of protection grows more gradually, but it is a critical ingredient over time for lowering both the number of deaths and reducing costs. Only protection slows the growth in the prevalence of disease and injury and thereby alleviates rather than exacerbates demand on limited primary care capacity. When added to a simulated scenario with coverage and care, protection could save 90 percent more lives and reduce costs by 30 percent in year 10; by year 25, that same investment in protection could save about 140 percent more lives and reduce costs by 62 percent.
C1 [Milstein, Bobby] Ctr Dis Control & Prevent, Syndem Prevent Network, Atlanta, GA 30333 USA.
[Homer, Jack] Homer Consulting, Voorhees, NJ USA.
[Briss, Peter] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
[Burton, Deron] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA USA.
[Pechacek, Terry] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA USA.
RP Milstein, B (reprint author), Ctr Dis Control & Prevent, Syndem Prevent Network, Atlanta, GA 30333 USA.
EM bmilstein@cdc.gov
NR 37
TC 32
Z9 32
U1 1
U2 8
PU PROJECT HOPE
PI BETHESDA
PA 7500 OLD GEORGETOWN RD, STE 600, BETHESDA, MD 20814-6133 USA
SN 0278-2715
J9 HEALTH AFFAIR
JI Health Aff.
PD MAY
PY 2011
VL 30
IS 5
BP 823
EP 832
DI 10.1377/hlthaff.2010.1116
PG 10
WC Health Care Sciences & Services; Health Policy & Services
SC Health Care Sciences & Services
GA 761WD
UT WOS:000290430800004
PM 21555468
ER
PT J
AU Pratt, RH
Winston, CA
Kammerer, JS
Armstrong, LR
AF Pratt, Robert H.
Winston, Carla A.
Kammerer, J. Steve
Armstrong, Lori R.
TI Tuberculosis in Older Adults in the United States, 1993-2008
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE tuberculosis; aged; surveillance; treatment outcomes; diagnosis
ID PULMONARY TUBERCULOSIS; ELDERLY PERSONS; INFECTION; REACTIVATION;
FACILITIES; RESIDENTS
AB OBJECTIVES: To describe older adults with tuberculosis (TB) and compare demographic, diagnostic, and disease characteristics and treatment outcomes between older and younger adults with TB.
DESIGN: Descriptive analysis of all confirmed people with TB aged 21 and older.
SETTING: The National Tuberculosis Surveillance System (NTSS) for the 50 United States and the District of Columbia from 1993 to 2008.
PARTICIPANTS: A total of 250,784 adult TB cases were reported, including 61,119 people with TB aged 65 and older.
MEASUREMENTS: TB case count and rates and proportion of TB cases in older adults.
RESULTS: Older adults had consistently higher incidence rates of TB than younger adults. In 2008, the rate of TB in older adults was 6.4 per 100,000, compared with 5.0 per 100,000 for younger adults. A lower percentage of older adults had TB diagnostic test results (tuberculin skin test, sputum smear, sputum culture) or human immunodeficiency virus (HIV) infection status reported. TB risk factors (substance use, homelessness, HIV infection) and multidrug-resistant TB were less prevalent in older than younger adults. Seven percent of older adults were dead at diagnosis, and 21% died during therapy, compared with 2% and 7%, respectively, of younger adults. Sputum culture conversion percentages were similar for people who did not die. Older adults also completed therapy in a timely manner, similar to younger adults.
CONCLUSION: Although older adults had higher rates of TB and mortality, for older adults who survived therapy, successful treatment outcomes were similar to those of younger adults. J Am Geriatr Soc 59:851-857, 2011.
C1 [Pratt, Robert H.; Winston, Carla A.; Armstrong, Lori R.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA.
[Pratt, Robert H.; Kammerer, J. Steve] Northrop Grumman Informat Syst, Atlanta, GA USA.
RP Pratt, RH (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, 1600 Clifton Rd,MS E 10, Atlanta, GA 30333 USA.
EM rpratt@cdc.gov
FU U.S. Centers for Disease Control and Prevention
FX The authors have no conflicts of interest to report. Funding was
provided solely by the U.S. Centers for Disease Control and Prevention.
NR 27
TC 18
Z9 19
U1 2
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0002-8614
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD MAY
PY 2011
VL 59
IS 5
BP 851
EP 857
DI 10.1111/j.1532-5415.2011.03369.x
PG 7
WC Geriatrics & Gerontology; Gerontology
SC Geriatrics & Gerontology
GA 763RZ
UT WOS:000290578700010
PM 21517786
ER
PT J
AU Friedman, SD
Cooper, EM
Calci, KR
Genthner, FJ
AF Friedman, Stephanie D.
Cooper, Emilie M.
Calci, Kevin R.
Genthner, Fred J.
TI Design and assessment of a real time reverse transcription-PCR method to
genotype single-stranded RNA male-specific coliphages (Family
Leviviridae)
SO JOURNAL OF VIROLOGICAL METHODS
LA English
DT Article
DE Genotype; Male-specific RNA coliphage; FRNA; F plus coliphage; Real-time
RT-PCR; Fecal source-tracking
ID RIBONUCLEIC-ACID COLIPHAGES; MICROBIAL SOURCE TRACKING; LINE BLOT
HYBRIDIZATION; F+-RNA; RT-PCR; FECAL POLLUTION; WASTE-WATER;
OLIGONUCLEOTIDE PROBES; INDICATOR BACTERIA; ESCHERICHIA-COLI
AB A real-time, reverse transcription-PCR (RT-qPCR) assay was developed to differentiate the four genogroups of male-specific ssRNA coliphages (FRNA) (family Leviviridae). As FRNA display a trend of source-specificity (human sewage or animal waste) at the genogroup level, this assay provides a tool to help identify the origin of fecal contamination. Primers and probes were designed using complete genomic sequences from 29 FRNA phages. The final selection of primer/probe sets were based on (i) ability to amplify a single, specific product, (ii) genogroup specificity, (iii) lack of cross-reactivity, and (iv) experimental reproducibility and sensitivity over a range of target concentrations. Assay time was reduced by using heat-released viral RNA rather than purified RNA. For quality assurance, a custom RNA molecule was employed as an internal, non-competitive control. The usefulness of this method to identify sources of fecal contamination was tested on a total of 49 FRNA phages isolated from various warm-blooded animals, sewage and combined sewage overflow. FRNA phages from animal wastes were genotyped as 86% I, 4% III Q-like and 9% IV. Two sewage isolates typed to genogroup I and combined sewage overflow isolates genotyped as 40% II and 52% III. Primer specificity designed from this comprehensive sequence database may better discriminate FRNA from different sources. Published by Elsevier B.V.
C1 [Friedman, Stephanie D.; Genthner, Fred J.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
[Cooper, Emilie M.] Ctr Dis Control & Prevent, Natl Calicivirus Lab, Gastroenteritis & Resp Viruses Lab Branch, Div Viral Dis, Atlanta, GA 30333 USA.
[Calci, Kevin R.] US PHS, Food & Drug Adm, Gulf Coast Seafood Lab, Dauphin Isl, AL 36528 USA.
RP Friedman, SD (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM friedman.stephanie@epa.gov; irw2@cdc.gov; Kevin.Calci@fda.hhs.gov;
genthner.fred@epa.gov
FU US Environmental Protection Agency; EPA's New England Regional Applied
Research Effort (RARE)
FX The information in this document has been funded wholly (or in part) by
the US Environmental Protection Agency. It has been subjected to review
by the National Health and Environmental Effects Research Laboratory and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
This is contribution number 1402 from the Gulf Ecology Division.; This
research was funded, in part, through EPA's New England Regional Applied
Research Effort (RARE). We gratefully acknowledge the assistance of Jack
Paar, III, U.S. EPA New England Regional Laboratory, for initiating and
sponsoring this program.
NR 60
TC 11
Z9 11
U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-0934
J9 J VIROL METHODS
JI J. Virol. Methods
PD MAY
PY 2011
VL 173
IS 2
BP 196
EP 202
DI 10.1016/j.jviromet.2011.02.005
PG 7
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Virology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Virology
GA 767DV
UT WOS:000290836400006
PM 21320531
ER
PT J
AU Ahluwalia, IB
Singleton, JA
Jamieson, DJ
Rasmussen, SA
Harrison, L
AF Ahluwalia, Indu B.
Singleton, James A.
Jamieson, Denise J.
Rasmussen, Sonja A.
Harrison, Leslie
TI Seasonal Influenza Vaccine Coverage Among Pregnant Women: Pregnancy Risk
Assessment Monitoring System
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID RESPIRATORY ILLNESS; INFANTS; VISITS; IMPACT; VIRUS; HOSPITALIZATIONS;
IMMUNIZATION; STATES
AB Since 2004, the American College of Obstetricians and Gynecologists (ACOG) and the Advisory Committee on Immunization Practices (ACIP) have recommended that pregnant women receive the seasonal influenza vaccine, regardless of pregnancy trimester, because of their increased risk for severe complications from influenza. However, the uptake of the influenza vaccine by pregnant women has been low. During the 2009-2010 influenza season, pregnant women were identified as a priority population to receive the influenza A (H1N1) 2009 (2009 H1N1) monovalent vaccine in addition to the seasonal influenza vaccine. In this issue, we highlight information from the 10 states that collected data using the survey administered by the Pregnancy Risk Assessment and Monitoring System (PRAMS) about seasonal vaccine coverage among women with recent live births and reasons for those who chose not to get vaccinated. The combined estimates from PRAMS of influenza vaccination coverage for the 2009-2010 season, which included data from October 2009 to March 2010, from 10 states were 50.7% for seasonal and 46.6% for 2009 H1N1 vaccine among women with recent live births. Among women who did not get vaccinated, reasons varied from worries about the safety of the vaccines for self and baby to not normally getting the vaccination. Further evaluation is needed on ways to increase influenza vaccination among pregnant women, effectively communicate the risk of influenza illness during pregnancy, and address women's concerns about influenza vaccination safety during pregnancy.
C1 [Ahluwalia, Indu B.; Singleton, James A.; Jamieson, Denise J.; Rasmussen, Sonja A.; Harrison, Leslie] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
RP Ahluwalia, IB (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,Mail Stop K-22, Atlanta, GA 30341 USA.
EM iahluwalia@cdc.gov
NR 24
TC 26
Z9 27
U1 0
U2 3
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD MAY
PY 2011
VL 20
IS 5
BP 649
EP 651
DI 10.1089/jwh.2011.2794
PG 3
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Obstetrics & Gynecology; Women's Studies
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Obstetrics & Gynecology; Women's Studies
GA 766MF
UT WOS:000290785800001
PM 21438700
ER
PT J
AU Kuklina, EV
Bateman, BT
AF Kuklina, Elena V.
Bateman, Brian T.
TI Pregnancy Complications and Prevention of Cardiovascular Disease in
Women: Stay Tuned
SO JOURNAL OF WOMENS HEALTH
LA English
DT Editorial Material
ID GENDER-SPECIFIC ASPECTS; C-REACTIVE PROTEIN; RISK-FACTORS; PREECLAMPSIA
C1 [Kuklina, Elena V.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
[Bateman, Brian T.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Anesthesia Crit Care & Pain Med, Boston, MA USA.
RP Kuklina, EV (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,MS K-37, Atlanta, GA 30341 USA.
EM ekuklina@cdc.gov
NR 22
TC 1
Z9 1
U1 0
U2 1
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD MAY
PY 2011
VL 20
IS 5
BP 657
EP 659
DI 10.1089/jwh.2011.2827
PG 3
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Obstetrics & Gynecology; Women's Studies
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Obstetrics & Gynecology; Women's Studies
GA 766MF
UT WOS:000290785800003
PM 21599426
ER
PT J
AU Gallo, MF
Warner, L
Bell, AJ
Bukusi, EA
Sharma, A
Njoroge, B
Ngugi, E
Jamieson, DJ
Eschenbach, DA
AF Gallo, Maria F.
Warner, Lee
Bell, April J.
Bukusi, Elizabeth A.
Sharma, Anjali
Njoroge, Betty
Ngugi, Elizabeth
Jamieson, Denise J.
Eschenbach, David A.
TI Determinants of Condom Use Among Female Sex Workers in Kenya: A
Case-Crossover Analysis
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID SEXUALLY-TRANSMITTED INFECTIONS; TRANS-AFRICA HIGHWAY; HIV TRANSMISSION;
UNPROTECTED SEX; UNSAFE SEX; RISK; BEHAVIOR; DESIGN; IMPACT; UGANDA
AB Background: We evaluated predictors of consistent condom use among female sex workers (FSWs), a core group for controlling the spread of HIV.
Methods: In an analysis of data collected in 2004-2005 from 140 Kenyan FSWs who completed questionnaires administered during a baseline study visit and three bimonthly follow-up visits, we used a case-crossover design to identify predictors of consistent condom use during all coital acts in the preceding 2 weeks, overall and by partner type.
Results: Participants (n = 140) completed the baseline visit and 390 bimonthly follow-up visits. Alcohol use during sex was negatively associated with consistent condom use with helping partners (defined as regular sex partners to whom the woman could go for help or support if needed) (adjusted odds ratio [AOR], 2.6, 95% confidence interval [CI] 1.0-6.5) but not associated with condom use with other partners. Coital frequency was associated with condom use with other partners only. Women who reported 1-5 (AOR 11.0, 95% CI 4.3-28.3) or 6-9 recent coital acts (AOR 3.8, 95% CI 1.7-8.8) with other partners were more likely to report consistent condom use with those partners than were women who reported >= 10 acts. Having a recent partner delay payment was inversely associated with consistent condom use with helping, other, or all partners.
Conclusions: Correlates of consistent condom use differed by partner type. By using a case-crossover design, we were able to identify potentially modifiable factors associated with consistent condom use by FSWs who used condoms consistently with a given partner type during some periods but not others.
C1 [Gallo, Maria F.; Warner, Lee; Bell, April J.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA.
[Bukusi, Elizabeth A.; Sharma, Anjali; Eschenbach, David A.] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA.
[Bukusi, Elizabeth A.] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA.
[Bukusi, Elizabeth A.; Sharma, Anjali; Njoroge, Betty] Kenya Govt Med Res Ctr, Ctr Microbiol Res, Nairobi, Kenya.
[Bukusi, Elizabeth A.; Njoroge, Betty] Univ Nairobi, Dept Obstet & Gynecol, Nairobi, Kenya.
[Sharma, Anjali] Univ Washington, Int Training & Educ Ctr HIV I TECH, Seattle, WA 98195 USA.
[Ngugi, Elizabeth] Univ Nairobi, Dept Community Hlth, Nairobi, Kenya.
[Ngugi, Elizabeth] Univ Nairobi, Ctr HIV Prevent & Res, Nairobi, Kenya.
RP Gallo, MF (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Highway,Mail Stop K-4, Atlanta, GA 30341 USA.
EM mgallo@cdc.gov
FU U.S. Centers for Disease Control and Prevention; U.S. Agency for
International Development; CONRAD
FX This study was funded by the U.S. Centers for Disease Control and
Prevention through an interagency agreement with the U.S. Agency for
International Development and CONRAD. The findings and conclusions in
this report are those of the authors and do not necessarily represent
the official position of the Centers for Disease Control and Prevention.
NR 29
TC 5
Z9 5
U1 0
U2 3
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD MAY
PY 2011
VL 20
IS 5
BP 733
EP 738
DI 10.1089/jwh.2010.2436
PG 6
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Obstetrics & Gynecology; Women's Studies
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Obstetrics & Gynecology; Women's Studies
GA 766MF
UT WOS:000290785800013
PM 21438697
ER
PT J
AU Edwards, KT
Goddard, J
Jones, TL
Paddock, CD
Varela-Stokes, AS
AF Edwards, Kristine T.
Goddard, Jerome
Jones, Tara L.
Paddock, Christopher D.
Varela-Stokes, Andrea S.
TI Cattle and the Natural History of Rickettsia parkeri in Mississippi
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Cattle; Ecology; Natural history; Rickettsia; Rickettsia parkeri
ID GULF-COAST TICK; AMBLYOMMA-MACULATUM KOCH; SPOTTED-FEVER; UNITED-STATES;
OKLAHOMA; IXODIDAE; AGENT; ACARI; HOSTS
AB Cattle have been recognized as hosts for Amblyomma maculatum, the Gulf Coast tick, for over 100 years. For nearly as long, A. maculatum have been known to harbor the spotted fever group Rickettsia (SFGR), now known as Rickettsia parkeri. However, human infection with R. parkeri was not documented until 2004. Results presented herein describe a laboratory and a field study evaluating cattle and the natural history of A. maculatum and R. parkeri in Mississippi. In the laboratory study, seroconversion to R. parkeri antigen occurred in calves exposed to R. parkeri by injection or by feeding R. parkeri-infected A. maculatum, and two out of six animals were transiently rickettsemic. All calves remained clinically normal during the study, except for gotch ear-like lesions in all tick-infested calves, regardless of infection status of ticks, suggesting that R. parkeri is not involved in the condition. In the field study, A. maculatum (n = 34) removed from Mississippi sale barn cattle (n = 183) and the cattle hosts were tested for R. parkeri. Cattle were not rickettsemic by polymerase chain reaction, but 49.7% demonstrated low titers to R. parkeri antigen when tested by indirect fluorescent antibody for SFGR. Of ticks removed from cattle, 11.8% were hemolymph positive and 8.7% were indirect fluorescent antibody positive. Approximately 22% (5/23) and 4% (1/23) of harvested tick extracts were positive for R. parkeri by polymerase chain reaction of the 17 kDa antigen gene and ompA gene, respectively. An amplicon for the ompA gene from one tick was successfully sequenced and showed 100% similarity with the homologous sequence of R. parkeri. Thus, cattle may harbor R. parkeri-infected A. maculatum and produce antibodies to SFGR. Cattle may play a role in the natural history of R. parkeri infection by expanding populations of A. maculatum and transporting R. parkeri-infected ticks to various locations, rather than as a reservoir for R. parkeri.
C1 [Edwards, Kristine T.; Goddard, Jerome] Mississippi State Univ, Dept Entomol & Plant Pathol, Mississippi State, MS 39762 USA.
[Jones, Tara L.; Paddock, Christopher D.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Varela-Stokes, Andrea S.] Mississippi State Univ, Coll Vet Med, Dept Basic Sci, Mississippi State, MS 39762 USA.
RP Edwards, KT (reprint author), Mississippi State Univ, Dept Entomol & Plant Pathol, 100 12 Lane, Mississippi State, MS 39762 USA.
EM kt20@msstate.edu
NR 27
TC 7
Z9 7
U1 2
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
EI 1557-7759
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD MAY
PY 2011
VL 11
IS 5
BP 485
EP 491
DI 10.1089/vbz.2010.0056
PG 7
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 765OD
UT WOS:000290717000004
PM 20846012
ER
PT J
AU Calisher, CH
Mills, JN
Root, JJ
Doty, JB
Beaty, BJ
AF Calisher, Charles H.
Mills, James N.
Root, Jon Jeffrey
Doty, Jeffrey B.
Beaty, Barry J.
TI The Relative Abundance of Deer Mice with Antibody to Sin Nombre Virus
Corresponds to the Occurrence of Hantavirus Pulmonary Syndrome in Nearby
Humans
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Antibody prevalence; Deer mice; Hantavirus pulmonary syndrome;
Peromyscus maniculatus; Population abundance; Risk factors; Rodents; Sin
Nombre virus
ID SOUTHWESTERN UNITED-STATES; PEROMYSCUS-MANICULATUS; NEW-MEXICO;
COLORADO; MONTANA; INFECTIONS; HISTORY; DISEASE; RNA
AB Sin Nombre virus (SNV) is the principal cause of hantavirus pulmonary syndrome (HPS) in the United States and deer mice (Peromyscus maniculatus) are its principal rodent host, and thus the natural cycle of the virus is related to the occurrence of HPS. Prevalence of rodent infection appears to be associated with fluctuations in deer mouse populations and, indirectly, with timing and amount of precipitation, a complex of biologic events. Given that rodent population abundances fluctuate, often acutely, it is not unreasonable to assume a direct correlation between the numbers of infected rodents and the number of human infections, unless confounding factors are involved. During a 13-year longitudinal study at a site in southwestern Colorado, we accumulated data regarding deer mice and antibody to SNV and therefore had the opportunity to compare dynamics of deer mouse populations, seroprevalence of antibody to SNV in the rodents, and numbers of HPS cases in Durango and in the State of Colorado as a whole. If abundances of deer mouse populations are directly correlated with occurrence of HPS, it is reasonable to assume that low densities of deer mice and low prevalences of antibody to SNV would lead to fewer human cases than would high densities and high prevalences. Our results substantiate such an assumption and suggest that the risk of acquisition of HPS is likely related to both high numbers of infected deer mice and human activities, rather than being strictly related to prevalence of SNV in the host rodent.
C1 [Calisher, Charles H.; Root, Jon Jeffrey; Doty, Jeffrey B.; Beaty, Barry J.] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA.
[Mills, James N.] US Ctr Dis Control & Prevent, Special Pathogens Branch, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis,Coordina, Atlanta, GA USA.
RP Calisher, CH (reprint author), Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Microbiol Immunol & Pathol, Arthropod Borne & Infect Dis Lab, Ft Collins, CO 80523 USA.
EM calisher@cybersafe.net
FU U.S. Centers for Disease Control and Prevention, Atlanta, Georgia
[U50/ccu809862-03]
FX We are grateful to Elisabeth Lawaczeck, DVM, Colorado Department of
Public Health and Environment, Denver, for providing human HPS case
data, including month of onset, county of exposure, county of residence,
and outcome of the case (whether died or survived). We also thank Arie
Ponce Manangan, Health Scientist/Geospatial Analyst/Geographer, Special
Pathogens Branch, Division of Viral and Rickettsial Diseases, National
Center for Zoonotic, Vector-Borne, and Enteric Diseases, U.S. Centers
for Disease Control and Prevention, Atlanta, Georgia, and John Pape,
formerly of the Disease Control and Environmental Epidemiology Division,
Colorado Department of Public Health and Environment, for providing
summarized hantavirus infection data for humans in Colorado. The authors
also are indebted to Richard J. Douglass, Montana Tech of Montana State
University, Bozeman, Montana, and Harvey Artsob, National Microbiology
Laboratory, Health Canada, Winnipeg, Manitoba, for allowing us to
publish their unpublished data regarding Montana and western Canada,
respectively, and for sharing with us their insightful observations.
Funding for this work was provided by the U.S. Centers for Disease
Control and Prevention, Atlanta, Georgia, under cooperative agreement
no. U50/ccu809862-03.
NR 23
TC 9
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U1 1
U2 15
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD MAY
PY 2011
VL 11
IS 5
BP 577
EP 582
DI 10.1089/vbz.2010.0122
PG 6
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 765OD
UT WOS:000290717000015
PM 20954865
ER
PT J
AU Golightly, YM
Hannan, MT
Shi, XA
Helmick, CG
Renner, JB
Jordan, JM
AF Golightly, Yvonne M.
Hannan, Marian T.
Shi, Xiaoyan Amy
Helmick, Charles G.
Renner, Jordan B.
Jordan, Joanne M.
TI Association of Foot Symptoms With Self-Reported and Performance-Based
Measures of Physical Function: The Johnston County Osteoarthritis
Project
SO ARTHRITIS CARE & RESEARCH
LA English
DT Article
ID KNEE OSTEOARTHRITIS; OLDER PERSONS; DISABILITY; PAIN; PEOPLE; ADULTS;
DETERMINANTS; PREVALENCE; LIMITATION; DISORDERS
AB Objective. To examine associations of foot symptoms with self-reported and performance-based measures of physical function in a large, biracial, community-based sample of individuals ages >= 45 years.
Methods. Data from 2,589 Johnston County participants (evaluated in 1999-2004) were used in cross-sectional analyses. The presence of foot symptoms was defined as pain, aching, or stiffness of at least one foot on most days. Physical function was assessed by the total Stanford Health Assessment Questionnaire (HAQ) score (0, >0 but <1, and >= 1), timed 5 repeated chair stands (completion time <12 seconds, >= 12 seconds, and unable), and 8-foot walk time (<3.35 seconds and >= 3.35 seconds). Separate multivariable logistic regression models examined associations between foot symptoms and physical function measures, controlling for age, race, sex, body mass index, radiographic knee osteoarthritis, radiographic hip osteoarthritis, knee symptoms, hip symptoms, and depressive symptoms. Interaction terms between each of the 3 physical function measures and each demographic and clinical characteristic were examined.
Results. The prevalence of foot symptoms was 37%. Participants with foot symptoms were more likely than those without symptoms to have higher HAQ scores (adjusted odds ratio [OR] 1.79, 95% confidence interval [95% CI] 1.50-2.12). Among obese participants, those with foot symptoms had longer chair stand (adjusted OR 1.38, 95% CI 1.04-1.87) and 8-foot walk times (adjusted OR 1.61, 95% CI 1.21-2.15) than those without symptoms.
Conclusion. Foot symptoms were independently and significantly associated with 2 of 3 measures of poorer physical function. Interventions for foot symptoms may be important for helping patients prevent or deal with an existing decline in physical function.
C1 [Golightly, Yvonne M.] Univ N Carolina, Thurston Arthritis Res Ctr, Chapel Hill, NC 27599 USA.
[Hannan, Marian T.] Inst Aging Res, Boston, MA USA.
[Hannan, Marian T.] Harvard Univ, Sch Med, Boston, MA USA.
[Helmick, Charles G.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Golightly, YM (reprint author), Univ N Carolina, Thurston Arthritis Res Ctr, 3300 Thurston Bldg,CB 7280, Chapel Hill, NC 27599 USA.
EM golight@email.unc.edu
OI Hannan, Marian/0000-0002-9586-6928
FU CDC; National Institute of Arthritis and Musculoskeletal and Skin
Diseases; NIH Arthritis and Immunology T-32 Training [AR-07416];
CDC/Association of Schools of Public Health [S043, S3486]; National
Institute of Arthritis and Musculoskeletal and Skin Diseases
Multipurpose Arthritis and Musculoskeletal Diseases Center
[5-P60-AR-30701]
FX The Johnston County Osteoarthritis Project was supported in part by the
CDC and the National Institute of Arthritis and Musculoskeletal and Skin
Diseases. Dr. Golightly's work was supported by the NIH Arthritis and
Immunology T-32 Training grant (AR-07416). Drs. Renner and Jordan's work
was supported by the CDC/Association of Schools of Public Health (grants
S043 and S3486) and the National Institute of Arthritis and
Musculoskeletal and Skin Diseases Multipurpose Arthritis and
Musculoskeletal Diseases Center (grant 5-P60-AR-30701).
NR 23
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U1 1
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 2151-464X
J9 ARTHRIT CARE RES
JI Arthritis Care Res.
PD MAY
PY 2011
VL 63
IS 5
BP 654
EP 659
DI 10.1002/acr.20432
PG 6
WC Rheumatology
SC Rheumatology
GA 761ZK
UT WOS:000290441800003
PM 21225678
ER
PT J
AU Valentin-Blasini, L
Blount, BC
Otero-Santos, S
Cao, Y
Bernbaum, JC
Rogan, WJ
AF Valentin-Blasini, Liza
Blount, Benjamin C.
Otero-Santos, Samaret
Cao, Yang
Bernbaum, Judy C.
Rogan, Walter J.
TI Perchlorate Exposure and Dose Estimates in Infants
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID THYROID-STIMULATING HORMONE; HUMAN-MILK; BREAST-MILK; IODINE;
CREATININE; EXCRETION; URINE; CHILDREN; BENEFITS; QUALITY
AB Perchlorate is a naturally occurring inorganic anion used as a component of solid rocket fuel, explosives, and pyrotechnics. Sufficiently high perchlorate intakes can modify thyroid function by competitively inhibiting iodide uptake in adults; however, little is known about perchlorate exposure and health effects in infants. Food intake models predict that infants have higher perchlorate exposure doses than adults. For this reason, we measured perchlorate and related anions (nitrate, thiccyanate, and iodide) in 206 urine samples from 92 infants ages 1-377 days and calculated perchlorate intake dose for this sample of infants. The median estimated exposure dose for this sample of infants was 0.160 mu g/kg/day. Of the 205 individual dose estimates, 9% exceeded the reference dose of 0.7 mu g/kg/day; 6% of infants providing multiple samples had multiple perchlorate dose estimates above the reference dose. Estimated exposure dose differed by feeding method: breast-fed infants had a higher perchlorate exposure dose (geometric mean 0.220 mu g/kg/day) than infants consuming cow milk-based formula (geometric mean 0.103 mu g/kg/day, p < 0.0001) or soy-based formula (geometric mean 0.027 mu g/kg/day, p < 0.0001), consistent with dose estimates based on dietary intake data. The ability of perchlorate to block adequate iodide uptake by the thyroid may have been reduced by the iodine-sufficient status of the infants studied (median urinary iodide 125 mu g/L). Further research is needed to see whether these perchlorate intake doses lead to any health effects.
C1 [Valentin-Blasini, Liza; Blount, Benjamin C.; Otero-Santos, Samaret] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA.
[Cao, Yang] Second Mil Med Univ, Fac Hlth Serv, Dept Hlth Stat, Shanghai, Peoples R China.
[Bernbaum, Judy C.] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA.
[Rogan, Walter J.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA.
RP Blount, BC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA.
EM BBlount@cdc.gov
RI Rogan, Walter/I-6034-2012;
OI Rogan, Walter/0000-0002-9302-0160; Cao, Yang/0000-0002-3552-9153
FU National Institutes of Health, National Institute of Environmental
Health Sciences
FX This work was partially supported by the Intramural Research Program of
the National Institutes of Health, National Institute of Environmental
Health Sciences
NR 39
TC 14
Z9 15
U1 3
U2 26
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAY 1
PY 2011
VL 45
IS 9
BP 4127
EP 4132
DI 10.1021/es103160j
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 753ZI
UT WOS:000289819400048
PM 21449579
ER
PT J
AU Leaffer, EB
Jacoby, A
Benn, E
Hauser, WA
Shih, T
Dayan, P
Green, R
Andrews, H
Thurman, DJ
Hesdorffer, D
AF Leaffer, Emily B.
Jacoby, Ann
Benn, Emma
Hauser, W. Allen
Shih, Tina
Dayan, Peter
Green, Robert
Andrews, Howard
Thurman, David J.
Hesdorffer, Dale
TI Associates of stigma in an incident epilepsy population from northern
Manhattan, New York City
SO EPILEPSY & BEHAVIOR
LA English
DT Article
DE Epilepsy; Stigma; Depression; Health status; Underserved populations;
Northern Manhattan
ID QUALITY-OF-LIFE; GENERAL-PRACTICE; COMMUNITY; PEOPLE; PSYCHOPATHOLOGY;
PERSPECTIVE
AB Objective: Stigma is associated with prevalent epilepsy, but its association with incident epilepsy is unknown.
Methods: We identified 209 children and adults with incident seizures from the diverse impoverished community of northern Manhattan. We interviewed 94 participants, aged 16 and older, about lifetime history of depression, health status, medical history, and stigma.
Results: At baseline, 18 (22.5%) participants reported experiencing stigma. Stigma was reported by 9 (50.0%) with depression and 9 (14.5%) without depression (P=0.002). At 1 year, 7 (8.1%) participants reported experiencing stigma. Stigma was reported by 5 (31.3%) with depression versus 1 (1.6%) without depression (P<0.0001). At both time points, odds of stigma increased when lifetime history of depression and fair/poor health was present.
Conclusions: Previous work revealed negative effects of prevalent epilepsy on stigma. In the low-income, predominantly Hispanic community of northern Manhattan, we found incident epilepsy was associated with stigma when lifetime history of depression or fair/poor health was present. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Leaffer, Emily B.; Benn, Emma; Hauser, W. Allen; Hesdorffer, Dale] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10032 USA.
[Leaffer, Emily B.; Benn, Emma; Hauser, W. Allen; Hesdorffer, Dale] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA.
[Jacoby, Ann] Univ Liverpool, Dept Hlth Inequal & Social Determinants Hlth, Liverpool L69 3BX, Merseyside, England.
[Benn, Emma; Andrews, Howard] Columbia Univ, Dept Biostat, New York, NY 10032 USA.
[Hauser, W. Allen] Columbia Univ, Dept Neurol, New York, NY 10032 USA.
[Shih, Tina] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA.
[Dayan, Peter] Columbia Univ, Dept Pediat, Morgan Stanley Childrens Hosp, New York, NY 10032 USA.
[Green, Robert] Columbia Univ, Dept Emergency Med, New York, NY 10032 USA.
[Thurman, David J.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
RP Hesdorffer, D (reprint author), Columbia Univ, Gertrude H Sergievsky Ctr, P & S Unit 16,630 W 168th St, New York, NY 10032 USA.
EM dch5@columbia.edu
FU Medical Research Council [G0800792]
NR 32
TC 11
Z9 11
U1 0
U2 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1525-5050
J9 EPILEPSY BEHAV
JI Epilepsy Behav.
PD MAY
PY 2011
VL 21
IS 1
BP 60
EP 64
DI 10.1016/j.yebeh.2011.03.007
PG 5
WC Behavioral Sciences; Clinical Neurology; Psychiatry
SC Behavioral Sciences; Neurosciences & Neurology; Psychiatry
GA 764MR
UT WOS:000290634200010
PM 21482485
ER
PT J
AU Janssens, ACJW
Ioannidis, JPA
van Duijn, CM
Little, J
Khoury, MJ
AF Janssens, A. Cecile J. W.
Ioannidis, John P. A.
van Duijn, Cornelia M.
Little, Julian
Khoury, Muin J.
CA GRIPS Grp
TI Strengthening the reporting of Genetic Risk Prediction Studies: The
GRIPS statement
SO GENETICS IN MEDICINE
LA English
DT Article
ID EPIDEMIOLOGY; MARKER; RECOMMENDATIONS; ASSOCIATION; ELABORATION;
EXPLANATION; GUIDELINES; MODELS; STROBE; IMPACT
C1 [Janssens, A. Cecile J. W.; van Duijn, Cornelia M.] Erasmus Univ, Dept Epidemiol, Med Ctr, NL-3000 CA Rotterdam, Netherlands.
[Ioannidis, John P. A.] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, GR-45110 Ioannina, Greece.
[Ioannidis, John P. A.] Fdn Res & Technol, Biomed Res Inst, Ioannina, Greece.
[Ioannidis, John P. A.] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA.
[Ioannidis, John P. A.] Tufts Med Ctr, Ctr Genet Epidemiol & Modeling, Boston, MA USA.
[Ioannidis, John P. A.] Tufts Med Ctr, Tufts CTSI, Inst Clin Res & Hlth Policy Studies, Boston, MA USA.
[Ioannidis, John P. A.] Stanford Univ, Stanford Prevent Res Ctr, Sch Med, Stanford, CA 94305 USA.
[Little, Julian] Univ Ottawa, Dept Epidemiol & Community Med, Ottawa, ON, Canada.
[Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA USA.
RP Janssens, ACJW (reprint author), Erasmus Univ, Dept Epidemiol, Med Ctr, POB 2040,Room Ee 21-87, NL-3000 CA Rotterdam, Netherlands.
EM a.janssens@erasmusmc.nl
RI Ioannidis, John/G-9836-2011; janssens, cecile/L-1075-2015;
OI Janssens, A Cecile/0000-0002-6153-4976
FU Centers for Disease Control and Prevention on behalf of the Human Genome
Epidemiology Network (HuGENet); Erasmus University Medical Center
Rotterdam; Center for Medical Systems Biology; Netherlands Organisation
for Scientific Research (NWO); National Institutes of Health/National
Center for Research Resources [UL1 RR025752]
FX Workshop was sponsored by the Centers for Disease Control and Prevention
on behalf of the Human Genome Epidemiology Network (HuGENet). The
findings and conclusions in this report are those of the authors and do
not necessarily reflect the views of the Department of Health and Human
Services. A. Cecile J.W. Janssens is financially supported by grants
from the Erasmus University Medical Center Rotterdam, the Center for
Medical Systems Biology in the framework of the Netherlands Genomics
Initiative (NGI) and the VIDI grant of the Netherlands Organisation for
Scientific Research (NWO). John P. A. Ioannidis: Tufts CTSI is supported
by the National Institutes of Health/National Center for Research
Resources (UL1 RR025752). Opinions in this paper are those of the
authors and do not necessarily represent the official position or
policies of the Tufts CTSI. Julian Little holds a Canada Research Chair
in Human Genome Epidemiology. The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
NR 26
TC 5
Z9 6
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1098-3600
J9 GENET MED
JI Genet. Med.
PD MAY
PY 2011
VL 13
IS 5
BP 453
EP 456
DI 10.1097/GIM.0b013e318212fa82
PG 4
WC Genetics & Heredity
SC Genetics & Heredity
GA 761XO
UT WOS:000290435700013
PM 21502867
ER
PT J
AU Ford, ES
Li, C
Zhao, G
Tsai, J
AF Ford, E. S.
Li, C.
Zhao, G.
Tsai, J.
TI Trends in obesity and abdominal obesity among adults in the United
States from 1999-2008
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE abdominal obesity; body mass index; population surveillance;
socioeconomic factors; trends; waist circumference
ID EDUCATIONAL-LEVEL; PUBLIC-HEALTH; US ADULTS; PREVALENCE; OVERWEIGHT;
POPULATION
AB Background and Objective: The United States has experienced a large increase in the prevalence of obesity since the 1970s. Our objective was to describe recent trends in obesity and abdominal obesity among adults in the United States.
Design: Trend study of cross-sectional studies.
Subjects: We used data from up to 22 872 men and non-pregnant women aged >= 20 years from the National Health and Nutrition Examination Survey (NHANES) 1999-2008.
Main Outcome Measures: Main outcome measures are mean body mass index and waist circumference, percentages of obesity and abdominal obesity. Obesity was defined as a body mass index >= 30 kg m(-2), and abdominal obesity was defined as a waist circumference >= 102 cm in men and >= 88 cm in women.
Results: In men, the age-adjusted mean body mass index, mean waist circumference, and prevalence of obesity and abdominal obesity were 27.8 kg m(-2), 99.1 cm, and 26.9 and 37.8%, respectively, during 1999-2000 and 28.5 kg m(-2) (P(trend) = 0.001), 100.8 cm (P(trend) = 0.002), and 32.0 (P(trend) = 0.001) and 43.7% (P(trend) = 0.002), respectively, during 2007-2008. In women, the age-adjusted mean body mass index, mean waist circumference, and prevalence of obesity and abdominal obesity were 28.2 kg m(-2), 92.2 cm, and 33.2 and 55.8%, respectively, during 1999-2000 and 28.6 kg m(-2) (P(trend) = 0.181), 94.9 cm (P(trend) = 0.006), and 35.2 (P(trend) = 0.180) and 61.8% (P(trend) = 0.036), respectively, during 2007-2008. Significant linear trends for increasing prevalence of obesity were noted among men with the least and most education.
Conclusion: Between 1999 and 2008, both obesity and abdominal obesity increased in men, and abdominal obesity increased in women. International Journal of Obesity (2011) 35, 736-743; doi: 10.1038/ijo.2010.186; published online 7 September 2010
C1 [Ford, E. S.; Li, C.; Zhao, G.; Tsai, J.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
RP Ford, ES (reprint author), Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway,Mailstop K66, Atlanta, GA 30341 USA.
EM eford@cdc.gov
NR 23
TC 70
Z9 73
U1 2
U2 18
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
J9 INT J OBESITY
JI Int. J. Obes.
PD MAY
PY 2011
VL 35
IS 5
BP 736
EP 743
DI 10.1038/ijo.2010.186
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 762WX
UT WOS:000290514000013
PM 20820173
ER
PT J
AU Hartley, TA
Shankar, A
Fekedulegn, D
Violanti, JM
Andrew, ME
Knox, SS
Burchfiel, CM
AF Hartley, Tara A.
Shankar, Anoop
Fekedulegn, Desta
Violanti, John M.
Andrew, Michael E.
Knox, Sarah S.
Burchfiel, Cecil M.
TI Metabolic Syndrome and Carotid Intima Media Thickness in Urban Police
Officers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID CARDIOVASCULAR-DISEASE MORBIDITY; ELEVATED BLOOD-PRESSURE;
LAW-ENFORCEMENT COHORT; CORONARY-HEART-DISEASE; SUBCLINICAL
ATHEROSCLEROSIS; RISK-FACTORS; PSYCHOSOCIAL FACTORS; PREMENOPAUSAL
WOMEN; YOUNG-ADULTS; MORTALITY
AB Objective: To examine the association between metabolic syndrome (MetSyn) and carotid intima media thickness (IMT) separately in male and female police officers. Methods: MetSyn was defined using 2005 guidelines. B-mode ultrasound was used to measure mean and maximum (12 and 36 segments) carotid artery thickness. Analysis of covariance was used to compare mean IMT values across individuals categorized by number of MetSyn components. Adjustments were made for age, smoking status, and low-density lipoprotein cholesterol. Results: Among 106 women, the adjusted mean common and maximum(36) carotid IMT were significantly and positively associated with number of MetSyn components. No associations were found in men (n = 304). Adjusted carotid IMT values were inversely associated with low high-density lipoprotein cholesterol and directly with hypertension in women. Conclusions: Number of MetSyn components was significantly associated with carotid IMT in female but not in male officers.
C1 [Hartley, Tara A.; Fekedulegn, Desta; Andrew, Michael E.; Burchfiel, Cecil M.] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
[Hartley, Tara A.; Shankar, Anoop; Knox, Sarah S.] W Virginia Univ, Sch Med, Dept Community Med, Morgantown, WV 26506 USA.
[Violanti, John M.] SUNY Buffalo, Dept Social & Prevent Med, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14260 USA.
RP Hartley, TA (reprint author), NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, 1095 Willowdale Rd,MS 4050, Morgantown, WV 26505 USA.
EM thartley@cdc.gov
FU National Institute for Occupational Safety and Health [200-2003-01580]
FX This work was supported by National Institute for Occupational Safety
and Health contract number 200-2003-01580.
NR 59
TC 11
Z9 11
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD MAY
PY 2011
VL 53
IS 5
BP 553
EP 561
DI 10.1097/JOM.0b013e3182171995
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 761WA
UT WOS:000290430500014
PM 21505360
ER
PT J
AU Barnes, LL
Wilson, RS
Hebert, LE
Scherr, PA
Evans, DA
de Leon, CFM
AF Barnes, Lisa L.
Wilson, Robert S.
Hebert, Liesi E.
Scherr, Paul A.
Evans, Denis A.
de Leon, Carlos F. Mendes
TI Racial Differences in the Association of Education With Physical and
Cognitive Function in Older Blacks and Whites
SO JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL
SCIENCES
LA English
DT Article
DE Education; Functional health; Health disparities; Race
ID ELIMINATING HEALTH DISPARITIES; CHILDHOOD SOCIOECONOMIC-STATUS;
AFRICAN-AMERICANS; UNITED-STATES; LATER LIFE; PSYCHOLOGICAL DISTRESS;
ALZHEIMERS-DISEASE; BLOOD-PRESSURE; PITT COUNTY; TEST-SCORES
AB Objectives. Few studies have explicitly tested whether the health disadvantage among older Blacks is consistent across the entire range of education. We examined racial differences in the cross-sectional association of education with physical and cognitive function performance in older adults.
Methods. Participants included over 9,500 Blacks and Whites, aged >= 65 years, from the Chicago Health and Aging Project {64% Black, 60% women, mean age = 73.0 (standard deviation [SD] = 6.9), mean education = 12.2 (SD = 3.5)}. Physical function was assessed using 3 physical performance tests, and cognitive function was assessed with 4 performance-based tests; composite measures were created and used in analyses.
Results. In multiple regression models that controlled for age, age-squared, sex, and race, and their interactions, Whites and those with higher education (> 12 years) performed significantly better on both functional health measures. The association of education with each indicator of functional health was similar in older Blacks and Whites with low levels (<= 12 years) of education. However, at higher levels of education, there was a significantly more positive association between years of education and these functional health outcomes among Blacks than Whites.
Discussion. Results from this biracial population-based sample in the Midwest suggest that Blacks may enjoy greater returns in functional health for additional education beyond high school.
C1 [Barnes, Lisa L.; Wilson, Robert S.] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA.
[Barnes, Lisa L.; Wilson, Robert S.; Evans, Denis A.] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA.
[Barnes, Lisa L.; Wilson, Robert S.] Rush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA.
[Hebert, Liesi E.; Evans, Denis A.; de Leon, Carlos F. Mendes] Rush Univ, Med Ctr, Rush Inst Healthy Aging, Chicago, IL 60612 USA.
[Scherr, Paul A.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
[Evans, Denis A.; de Leon, Carlos F. Mendes] Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA.
RP Barnes, LL (reprint author), Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, 600 S Paulina,Suite 1038, Chicago, IL 60612 USA.
EM lbarnes1@rush.edu
FU National Institute on Aging [AG11101, AG10161, AG22018]; National
Institute of Environmental Health Sciences at the National Institutes of
Health [ES 10902]
FX National Institute on Aging (AG11101 and AG10161 to DAE, and AG22018 to
LLB); National Institute of Environmental Health Sciences (ES 10902 to
CFMdL) at the National Institutes of Health.
NR 69
TC 13
Z9 13
U1 2
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5014
J9 J GERONTOL B-PSYCHOL
JI J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.
PD MAY
PY 2011
VL 66
IS 3
BP 354
EP 363
DI 10.1093/geronb/gbr016
PG 10
WC Geriatrics & Gerontology; Gerontology; Psychology; Psychology,
Multidisciplinary
SC Geriatrics & Gerontology; Psychology
GA 757GG
UT WOS:000290072900010
PM 21402644
ER
PT J
AU Zbikowski, SM
Jack, LM
McClure, JB
Deprey, M
Javitz, HS
McAfee, TA
Catz, SL
Richards, J
Bush, T
Swan, GE
AF Zbikowski, Susan M.
Jack, Lisa M.
McClure, Jennifer B.
Deprey, Mona
Javitz, Harold S.
McAfee, Timothy A.
Catz, Sheryl L.
Richards, Julie
Bush, Terry
Swan, Gary E.
TI Utilization of Services in a Randomized Trial Testing Phone- and
Web-Based Interventions for Smoking Cessation
SO NICOTINE & TOBACCO RESEARCH
LA English
DT Article
ID NICOTINE PATCH; COST-EFFECTIVENESS; INTERNET; PROGRAM; VARENICLINE;
MEDIATORS; QUITLINE; USERS
AB Introduction: Phone counseling has become standard for behavioral smoking cessation treatment. Newer options include Web and integrated phone-Web treatment. No prior research, to our knowledge, has systematically compared the effectiveness of these three treatment modalities in a randomized trial. Understanding how utilization varies by mode, the impact of utilization on outcomes, and predictors of utilization across each mode could lead to improved treatments.
Methods: One thousand two hundred and two participants were randomized to phone, Web, or combined phone-Web cessation treatment. Services varied by modality and were tracked using automated systems. All participants received 12 weeks of varenicline, printed guides, an orientation call, and access to a phone supportline. Self-report data were collected at baseline and 6-month follow-up.
Results: Overall, participants utilized phone services more often than the Web-based services. Among treatment groups with Web access, a significant proportion logged in only once (37% phone-Web, 41% Web), and those in the phone-Web group logged in less often than those in the Web group (mean = 2.4 vs. 3.7, p = .0001). Use of the phone also was correlated with increased use of the Web. In multivariate analyses, greater use of the phone- or Web-based services was associated with higher cessation rates. Finally, older age and the belief that certain treatments could improve success were consistent predictors of greater utilization across groups. Other predictors varied by treatment group.
Conclusions: Opportunities for enhancing treatment utilization exist, particularly for Web-based programs. Increasing utilization more broadly could result in better overall treatment effectiveness for all intervention modalities.
C1 [Zbikowski, Susan M.; Deprey, Mona; Bush, Terry] Free & Clear Inc, Clin & Behav Sci, Seattle, WA USA.
[Jack, Lisa M.; Javitz, Harold S.; Swan, Gary E.] SRI Int, Ctr Hlth Sci, Menlo Pk, CA 94025 USA.
[McClure, Jennifer B.; Catz, Sheryl L.; Richards, Julie] Grp Hlth Res Inst, Seattle, WA USA.
[McAfee, Timothy A.] Ctr Dis Control, Atlanta, GA 30333 USA.
RP Zbikowski, SM (reprint author), 999 3rd Ave,Suite 2100, Seattle, WA 98104 USA.
EM susan.zbikowski@freeclear.com
FU National Cancer Institute [R01CA071358]; Pfizer
FX This study was funded by the National Cancer Institute (grant #
R01CA071358) and is registered at Clinicaltrials.gov (NCT00301145).
Varenicline and nominal support for recruiting participants were
provided by Pfizer, Inc. Neither funding entity had any role in the
study design, the collection, analysis, and interpretation of data, in
the writing of the report, or in the decision to submit the report for
publication.; Dr. SMZ and Ms. MD are employed by Free & Clear, Inc. Dr.
TAM was employed by Free & Clear, Inc. at the time the research was
conducted. Dr. GES received financial support from Pfizer to attend a
one-day advisory meeting in 2008. The authors have no other potential
conflicts of interest to report.
NR 33
TC 29
Z9 29
U1 1
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1462-2203
EI 1469-994X
J9 NICOTINE TOB RES
JI Nicotine Tob. Res.
PD MAY
PY 2011
VL 13
IS 5
BP 319
EP 327
DI 10.1093/ntr/ntq257
PG 9
WC Substance Abuse; Public, Environmental & Occupational Health
SC Substance Abuse; Public, Environmental & Occupational Health
GA 757LR
UT WOS:000290087000004
PM 21330267
ER
PT J
AU Catz, SL
Jack, LM
McClure, JB
Javitz, HS
Deprey, M
Zbikowski, SM
McAfee, T
Richards, J
Swan, GE
AF Catz, Sheryl L.
Jack, Lisa M.
McClure, Jennifer B.
Javitz, Harold S.
Deprey, Mona
Zbikowski, Susan M.
McAfee, Tim
Richards, Julie
Swan, Gary E.
TI Adherence to Varenicline in the COMPASS Smoking Cessation Intervention
Trial
SO NICOTINE & TOBACCO RESEARCH
LA English
DT Article
ID SUSTAINED-RELEASE BUPROPION; RANDOMIZED CONTROLLED-TRIAL; RECEPTOR
PARTIAL AGONIST; MEDICATION ADHERENCE; DOUBLE-BLIND; NICOTINE PATCH;
CLINICAL-TRIAL; NASAL SPRAY; THERAPY; SMOKERS
AB Introduction: Patient adherence to smoking cessation medications can impact their effectiveness. It is important to understand the extent to which prescribed medications are actually taken by smokers, how this influences smoking cessation outcomes, and what factors may influence adherence.
Methods: Smokers recruited from a large health plan were randomized to receive different modes of cessation counseling in combination with varenicline (Swan, G. E., McClure, J. B., Jack, L. M., Zbikowski, S. M., Javitz, H. S., Catz, S. L., et al. 2010.Behavioral counseling and varenicline treatment for smoking cessation. American Journal of Preventive Medicine, 38, 482-490). One thousand one hundred and sixty-one participants were mailed a 28-day varenicline supply when they set a quit date and were able to request up to two refills from the health plan pharmacy at no cost. Pharmacy fill records were obtained and telephone surveys completed at baseline, 21 days, 12 weeks, and 6 months post target quit date.
Results: Good adherence to varenicline (>= 80% of days taken) was associated with a twofold increase in 6-month quit rates compared with poor adherence (52% vs. 25%). Smokers were more likely than nonsmokers to stop varenicline early. Purposeful nonadherence was associated with smoking at 12 weeks and was predicted in multivariate analyses by age, gender, adherence self-efficacy, and initial medication side effect severity.
Conclusions: Innovative methods for increasing adherence to smoking cessation medications are needed, particularly early in the quit process. Simple metrics of adherence such as number of days cessation medication is taken can and should be routinely incorporated in effectiveness trials and reported to advance future attempts to understand and reduce nonadherence.
C1 [Catz, Sheryl L.; McClure, Jennifer B.; Richards, Julie] Grp Hlth Res Inst, Seattle, WA 98101 USA.
[Jack, Lisa M.; Javitz, Harold S.; Swan, Gary E.] SRI Int, Menlo Pk, CA 94025 USA.
[Deprey, Mona; Zbikowski, Susan M.] Free & Clear Inc, Seattle, WA USA.
[McAfee, Tim] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA USA.
RP Catz, SL (reprint author), Grp Hlth Res Inst, 1730 Minor Ave,Suite 1600, Seattle, WA 98101 USA.
EM catz.s@ghc.org
FU Pfizer; National Cancer Institute of the National Institutes of Health
[R01-CA071358]
FX Dr. GES received financial support from Pfizer to attend a one-day
advisory meeting in 2008. This research was sponsored by a grant to SRI
International by the National Cancer Institute of the National
Institutes of Health (R01-CA071358).
NR 32
TC 36
Z9 36
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1462-2203
J9 NICOTINE TOB RES
JI Nicotine Tob. Res.
PD MAY
PY 2011
VL 13
IS 5
BP 361
EP 368
DI 10.1093/ntr/ntr003
PG 8
WC Substance Abuse; Public, Environmental & Occupational Health
SC Substance Abuse; Public, Environmental & Occupational Health
GA 757LR
UT WOS:000290087000009
PM 21350041
ER
PT J
AU Feldkamp, ML
Carmichael, SL
Shaw, GM
Panichello, JD
Moore, CA
Botto, LD
AF Feldkamp, Marcia L.
Carmichael, Suzan L.
Shaw, Gary M.
Panichello, Janice D.
Moore, Cynthia A.
Botto, Lorenzo D.
TI Maternal nutrition and gastroschisis: findings from the National Birth
Defects Prevention Study
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE case-control study; epidemiology; gastroschisis; nutrients; nutrition
ID BODY-MASS INDEX; RISK; PREGNANCY; WOMEN
AB OBJECTIVE: Gastroschisis is increasing in many countries, especially among young women. Because young women may have inadequate nutrition, we assessed the relationship between individual nutrients and the risk for gastroschisis.
STUDY DESIGN: We analyzed data from the National Birth Defects Prevention Study, a population-based case-control study. Cases were ascertained from 10 birth defect surveillance systems. Controls were randomly selected from birth certificates or hospital records. Nutrient intake was estimated for the year prior to conception from maternal interviews based on a 58-item food frequency questionnaire and cereal consumption reported. A total of 694 cases and 6157 controls were available for analysis.
RESULTS: Reported intake of individual nutrients did not substantially affect the risk for gastroschisis. Stratification by maternal age, preconception body mass index, folic acid-containing supplements, or energy intake (kilocalories) did not alter risk estimates.
CONCLUSION: This study does not support an increased risk for gastroschisis with decreasing tertiles of individual nutrients.
C1 [Feldkamp, Marcia L.] Univ Utah, Div Med Genet, Hlth Sci Ctr, Dept Pediat, Salt Lake City, UT 84132 USA.
[Feldkamp, Marcia L.; Panichello, Janice D.; Botto, Lorenzo D.] Utah Dept Hlth, Utah Birth Defect Network, Salt Lake City, UT 84116 USA.
[Carmichael, Suzan L.; Shaw, Gary M.] Stanford Univ, Sch Med, Div Neonatol, Dept Pediat, Palo Alto, CA 94304 USA.
[Moore, Cynthia A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
RP Feldkamp, ML (reprint author), Univ Utah, Div Med Genet, Hlth Sci Ctr, Dept Pediat, 2C 412 SOM,50 N Mario Capecchi Dr, Salt Lake City, UT 84132 USA.
EM marcia.feldkamp@hsc.utah.edu
RI Publications, NBDPS/B-7692-2013
FU Centers for Disease Control and Prevention [U50/CCU822097,
U01-DD000490]; University of North Carolina Clinical Nutrition Research
Center [DK56350]
FX This study was supported by Cooperative Agreement nos. U50/CCU822097 and
U01-DD000490 from the Centers for Disease Control and Prevention and
Grant no. DK56350 from the Nutrition Epidemiology Core of the University
of North Carolina Clinical Nutrition Research Center.
NR 26
TC 2
Z9 2
U1 1
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD MAY
PY 2011
VL 204
IS 5
AR 404.e1
DI 10.1016/j.ajog.2010.12.053
PG 10
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 758YZ
UT WOS:000290206200025
PM 21396620
ER
PT J
AU Chowdhury, R
Dotson, E
Blackstock, AJ
McClintock, S
Maheswary, NP
Faria, S
Islam, S
Akter, T
Kroeger, A
Akhter, S
Bern, C
AF Chowdhury, Rajib
Dotson, Ellen
Blackstock, Anna J.
McClintock, Shannon
Maheswary, Narayan P.
Faria, Shyla
Islam, Saiful
Akter, Tangin
Kroeger, Axel
Akhter, Shireen
Bern, Caryn
TI Comparison of Insecticide-Treated Nets and Indoor Residual Spraying to
Control the Vector of Visceral Leishmaniasis in Mymensingh District,
Bangladesh
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID PHLEBOTOMUS-ARGENTIPES; INDIAN SUBCONTINENT; KALA-AZAR; ELIMINATION;
NEPAL
AB Integrated vector management is a pillar of the South Asian visceral leishmaniasis (VL) elimination program, but the best approach remains a matter of debate. Sand fly seasonality was determined in 40 houses sampled monthly. The impact of interventions on Phlebotomus argentipes density was tested from 2006-2007 in a cluster-randomized trial with four arms: indoor residual spraying (IRS), insecticide-treated nets (ITNs), environmental management (EVM), and no intervention. Phlebotomies argentipes density peaked in March with the highest proportion of gravid females in May. The EVM (mud plastering of wall and floor cracks) showed no impact. The IRS and ITNs were associated with a 70-80% decrease in male and female P argentipes density up to 5 months post intervention. Vector density rebounded by 11 months post-IRS, whereas ITN-treated households continued to show significantly lower density compared with households without intervention. Our data suggest that both IRS and ITNs may help to improve VL control in Bangladesh.
C1 [Dotson, Ellen; Blackstock, Anna J.; McClintock, Shannon; Bern, Caryn] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, DPD CDC, Atlanta, GA 30341 USA.
[Chowdhury, Rajib] WHO, Reg Off SE Asia, New Delhi, India.
[Maheswary, Narayan P.; Faria, Shyla; Islam, Saiful; Akhter, Shireen] Natl Inst Prevent & Social Med, Dhaka 1212, Bangladesh.
[Akter, Tangin] Univ Dhaka, Dept Zool, Dhaka 1000, Bangladesh.
[Kroeger, Axel] WHO, Special Programme Res & Training Trop Dis, CH-1211 Geneva, Switzerland.
Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England.
RP Bern, C (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, DPD CDC, 4770 Buford Highway NE,MS F-22, Atlanta, GA 30341 USA.
EM rajib478@yahoo.com; ebd6@cdc.gov; hyp9@cdc.gov; smcclin@emory.edu;
narayanmaheswary@yahoo.com; shylafaria@yahoo.com; tapu_fh@yahoo.com;
aktert1@yahoo.com; kroegera@who.int; shireen_nipsom@yahoo.com;
cxb9@cdc.gov
RI Pileggi, Shannon/L-1320-2016
OI Kroeger, Axel/0000-0001-8438-2904; Pileggi, Shannon/0000-0002-7732-4164
FU Centers for Disease Control and Prevention Emerging Infections
Initiative; World Health Organization
FX The 2002-2003 study was funded by a grant from the Centers for Disease
Control and Prevention Emerging Infections Initiative. The 2006-2007
study was funded by the Special Programme for Research and Training in
Tropical Diseases, World Health Organization.
NR 18
TC 12
Z9 12
U1 0
U2 8
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD MAY
PY 2011
VL 84
IS 5
BP 662
EP 667
DI 10.4269/ajtmh.2011.10-0682
PG 6
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 760ZW
UT WOS:000290365100003
PM 21540372
ER
PT J
AU White, GS
Pickett, BE
Lefkowitz, EJ
Johnson, AG
Ottendorfer, C
Stark, LM
Unnasch, TR
AF White, Gregory S.
Pickett, Brett E.
Lefkowitz, Elliot J.
Johnson, Amelia G.
Ottendorfer, Christy
Stark, Lillian M.
Unnasch, Thomas R.
TI Phylogenetic Analysis of Eastern Equine Encephalitis Virus Isolates from
Florida
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID ENCEPHALOMYELITIS VIRUS; CENTRAL ALABAMA; TRANSMISSION; EVOLUTION;
VENEZUELAN; VERTEBRATE; ARBOVIRUS; INFERENCE; MRBAYES; MODELS
AB Florida has the highest degree of endemicity for eastern equine encephalitis virus (EEEV) of any state in the United States and is the only state with year-round transmission of EEEV. To further understand the viral population dynamics in Florida, the genome sequence of six EEEV isolates from central Florida were determined. These data were used to identify the most polymorphic regions of the EEEV genome from viruses isolated in Florida. The sequence of these polymorphic regions was then determined for 18 additional Florida isolates collected in four geographically distinct regions over a 20-year period. Phylogenetic analyses of these data suggested a rough temporal association of the Florida isolates, but no clustering by region or by source of the isolate. Some clustering of northeastern isolates with Florida isolates was seen, providing support for the hypothesis that Florida serves as a reservoir for the periodic introduction of EEEV into the northeastern United States.
C1 [Johnson, Amelia G.; Unnasch, Thomas R.] Univ S Florida, Global Hlth Infect Dis Res Program, Dept Global Hlth, Tampa, FL 33612 USA.
[Pickett, Brett E.] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA.
[Lefkowitz, Elliot J.] Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA.
[Ottendorfer, Christy] Ctr Dis Control & Prevent, Atlanta, GA USA.
Florida Dept Hlth Bur Labs, Tampa, FL USA.
RP Unnasch, TR (reprint author), Univ S Florida, Global Hlth Infect Dis Res Program, Dept Global Hlth, 3720 Spectrum Blvd,Suite 304, Tampa, FL 33612 USA.
EM gwhite@cvmvcd.org; bpickett@uab.edu; elliotl@uab.edu;
ajohnso3@health.usf.edu; cottendorfer@gmail.com;
lillian_stark@doh.state.fl.us; tunnasch@health.usf.edu
OI Lefkowitz, Elliot/0000-0002-4748-4925
FU National Institute of Allergy and Infectious Diseases [R01 AI049724]
FX This study was supported by a grant from the National Institute of
Allergy and Infectious Diseases (Project # R01 AI049724) to Thomas R.
Unnasch.
NR 31
TC 6
Z9 6
U1 0
U2 4
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD MAY
PY 2011
VL 84
IS 5
BP 709
EP 717
DI 10.4269/ajtmh.2011.10-0267
PG 9
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 760ZW
UT WOS:000290365100010
PM 21540379
ER
PT J
AU Verani, JR
Abudho, B
Montgomery, SP
Mwinzi, PNM
Shane, HL
Butler, SE
Karanja, DMS
Secor, WE
AF Verani, Jennifer R.
Abudho, Bernard
Montgomery, Susan P.
Mwinzi, Pauline N. M.
Shane, Hillary L.
Butler, Sara E.
Karanja, Diana M. S.
Secor, W. Evan
TI Schistosomiasis among Young Children in Usoma, Kenya
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID WESTERN KENYA; HAEMATOBIUM INFECTION; PRESCHOOL-CHILDREN; MANSONI
INFECTION; IMMUNE-RESPONSES; LAKE VICTORIA; COMMUNITY; SCHOOLCHILDREN;
SHORELINE; PATTERNS
AB Although schistosomiasis burden is greatest among school-age children (SAC) (6-15 years of age), infection among preschool-age children (PSAC) (1-5 years), may be underestimated in endemic areas. We conducted a cross-sectional study evaluating Schistosoma mansoni infection among children 1-15 years of age in a highly endemic community in Kenya. Diagnostic tests included stool exam (Kato/Katz technique), serum testing for schistosome-specific antibodies, and urine testing for circulating cathodic antigen (CCA). Overall, 268 SAC and 216 PSAC were enrolled; prevalence increased with age, with 14% of 1 year olds and more than 90% of children > 10 years of age infected. Stool exam was more sensitive among SAC than PSAC, but performance was similar after adjusting for infection intensity (based on CCA). Schistosomiasis poses a threat to PSAC in endemic areas, and stool exam may underestimate the prevalence of infection. Control programs in such areas should consider PSAC in addition to SAC.
C1 [Secor, W. Evan] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA 30329 USA.
Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya.
[Shane, Hillary L.] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA.
RP Secor, WE (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, 1600 Clifton Rd, Atlanta, GA 30329 USA.
EM QZR7@cdc.gov; bernabu002@yahoo.com; ZQU6@cdc.gov; PMwinzi@ke.cdc.gov;
hshane7@gmail.com; CSU8@cdc.gov; DKaranja@ke.cdc.gov; WAS4@cdc.gov
NR 28
TC 25
Z9 25
U1 0
U2 4
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD MAY
PY 2011
VL 84
IS 5
BP 787
EP 791
DI 10.4269/ajtmh.2011.10-0685
PG 5
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 760ZW
UT WOS:000290365100021
PM 21540390
ER
PT J
AU Kiggundu, M
Nsobya, SL
Kamya, MR
Filler, S
Nasr, S
Dorsey, G
Yeka, A
AF Kiggundu, Moses
Nsobya, Samuel L.
Kamya, Moses R.
Filler, Scott
Nasr, Sussan
Dorsey, Grant
Yeka, Adoke
TI Evaluation of a Comprehensive Refresher Training Program in Malaria
Microscopy Covering Four Districts of Uganda
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID HEALTH-CARE LEVEL; DIAGNOSIS; MANAGEMENT; ACCURACY; TANZANIA
AB Microscopy remains the gold standard for malaria diagnosis. However, quality microscopy services are severely lacking in most African countries. To improve capacity for malaria microscopy in Uganda, a 3-day refresher training program was conducted in four districts. Training impact was measured through a written examination and evaluation of the quality of blood-slide preparation and accuracy of field microscopy. A total of 184 of 192 (96%) identified laboratory personnel participated in the training. Average test scores improved from 41% to 75% (P < 0.001). A total of 1,079 and 1,190 routinely made thick blood smears were collected before and after the training, respectively. Sensitivity improved from 84% to 95% (P < 0.001), and specificity improved from 87% to 97% (P < 0.001). The proportion of well-prepared blood smears improved from 6% to 75% (P < 0.001). Supplemental training can have a significant impact on the knowledge of staff, accuracy of microscopy, and quality of blood-slide preparation.
C1 Makerere Univ, Sch Med, Dept Med, Kampala, Uganda.
Ctr Dis & Prevent, Malaria Branch, Atlanta, GA USA.
Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
[Kiggundu, Moses; Nsobya, Samuel L.; Yeka, Adoke] Mulago Hosp Complex, Uganda Malaria Surveillance Program, Kampala, Uganda.
[Kamya, Moses R.] Univ Calif San Francisco, Makerere Univ, Malaria Res Collaborat, Kampala, Uganda.
[Filler, Scott] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis, Atlanta, GA USA.
[Nasr, Sussan] Ctr Dis Control & Prevent, Presidents Malaria Initiat, Kampala, Uganda.
RP Yeka, A (reprint author), Mulago Hosp Complex, Uganda Malaria Surveillance Program, POB 7475, Kampala, Uganda.
EM mkiggundu@muucsf.org; samnsobya@yahoo.co.uk; mkamya@nfocom.co.ug;
SFiller@cdc.gov; icz1@cdc.gov; gdorsey@medsfgh.ucsf.edu;
yadoke@muucsf.org
FU President's Malaria Initiative through Centers for Disease Control and
Prevention [U50/CCU925122]
FX This study received financial support from the President's Malaria
Initiative through a cooperative agreement with the Centers for Disease
Control and Prevention (U50/CCU925122).
NR 19
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U2 3
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD MAY
PY 2011
VL 84
IS 5
BP 820
EP 824
DI 10.4269/ajtmh.2011.10-0597
PG 5
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 760ZW
UT WOS:000290365100027
PM 21540396
ER
PT J
AU Campbell, PJ
Morlock, GP
Sikes, RD
Dalton, TL
Metchock, B
Starks, AM
Hooks, DP
Cowan, LS
Plikaytis, BB
Posey, JE
AF Campbell, Patricia J.
Morlock, Glenn P.
Sikes, R. David
Dalton, Tracy L.
Metchock, Beverly
Starks, Angela M.
Hooks, Delaina P.
Cowan, Lauren S.
Plikaytis, Bonnie B.
Posey, James E.
TI Molecular Detection of Mutations Associated with First- and Second-Line
Drug Resistance Compared with Conventional Drug Susceptibility Testing
of Mycobacterium tuberculosis
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID ETHAMBUTOL RESISTANCE; RIFAMPIN RESISTANCE; EMBB306 MUTATIONS;
CROSS-RESISTANCE; GYRASE MUTATIONS; RPOB MUTATIONS; KANAMYCIN; STRAINS;
CAPREOMYCIN; SEQUENCE
AB The emergence of multi- and extensively drug-resistant tuberculosis is a significant impediment to the control of this disease because treatment becomes more complex and costly. Reliable and timely drug susceptibility testing is critical to ensure that patients receive effective treatment and become noninfectious. Molecular methods can provide accurate and rapid drug susceptibility results. We used DNA sequencing to detect resistance to the first-line antituberculosis drugs isoniazid (INH), rifampin (RIF), pyrazinamide (PZA), and ethambutol (EMB) and the second-line drugs amikacin (AMK), capreomycin (CAP), kanamycin (KAN), ciprofloxacin (CIP), and ofloxacin (OFX). Nine loci were sequenced: rpoB (for resistance to RIF), katG and inhA (INH), pncA (PZA), embB (EMB), gyrA (CIP and OFX), and rrs, eis, and tlyA (KAN, AMK, and CAP). A total of 314 clinical Mycobacterium tuberculosis complex isolates representing a variety of antibiotic resistance patterns, genotypes, and geographical origins were analyzed. The molecular data were compared to the phenotypic data and the accuracy values were calculated. Sensitivity and specificity values for the first-line drug loci were 97.1% and 93.6% for rpoB, 85.4% and 100% for katG, 16.5% and 100% for inhA, 90.6% and 100% for katG and inhA together, 84.6% and 85.8% for pncA, and 78.6% and 93.1% for embB. The values for the second-line drugs were also calculated. The size and scope of this study, in numbers of loci and isolates examined, and the phenotypic diversity of those isolates support the use of DNA sequencing to detect drug resistance in the M. tuberculosis complex. Further, the results can be used to design diagnostic tests utilizing other mutation detection technologies.
C1 [Campbell, Patricia J.; Morlock, Glenn P.; Sikes, R. David; Dalton, Tracy L.; Metchock, Beverly; Starks, Angela M.; Hooks, Delaina P.; Cowan, Lauren S.; Plikaytis, Bonnie B.; Posey, James E.] Ctr Dis Control & Prevent, Mycobacteriol Lab Branch, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
RP Posey, JE (reprint author), CDC, Mycobacteriol Lab Branch, 1600 Clifton Rd NE,Bldg 17,Room 4029,M-S F08, Atlanta, GA 30333 USA.
EM jposey@cdc.gov
NR 45
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Z9 156
U1 0
U2 29
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD MAY
PY 2011
VL 55
IS 5
BP 2032
EP 2041
DI 10.1128/AAC.01550-10
PG 10
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 756NM
UT WOS:000290019200028
PM 21300839
ER
PT J
AU Weeks, JN
Boyd, KL
Rajam, G
Ades, EW
McCullers, JA
AF Weeks, Jenni N.
Boyd, Kelli L.
Rajam, Gowrisankar
Ades, Edwin W.
McCullers, Jonathan A.
TI Immunotherapy with a Combination of Intravenous Immune Globulin and P4
Peptide Rescues Mice from Postinfluenza Pneumococcal Pneumonia
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID SECONDARY BACTERIAL PNEUMONIA; CRITICALLY-ILL PATIENTS; 2009 INFLUENZA
A(H1N1); PANDEMIC INFLUENZA; MOUSE MODEL; SURFACE ADHESIN;
UNITED-STATES; A H1N1; INFECTION; VIRUS
AB Alternate therapies are needed for treatment of secondary bacterial pneumonia following influenza. The immunomodulatory peptide P4 has shown promise in mouse models of primary pneumococcal infection. Mice infected with influenza virus and then challenged with Streptococcus pneumoniae were treated with a combination of P4 peptide and intravenous immune globulin. Survival was improved from 20% to 80% in treated mice relative to controls. Clinical cure correlated with increased clearance of bacteria and decreased lung consolidation. Greater trafficking of professional phagocytic cells to the site of pneumococcal infection coupled with enhanced opsonophagocytosis as manifest by decreased surface display of Fc gamma receptors (Fc gamma R) on neutrophils and macrophages were associated with P4 peptide treatment. This suggests that the mechanism of action for improved clearance of bacteria engendered by P4 is through improved uptake by phagocytes mediated by IgG Fc-Fc gamma receptor interactions following antibody-mediated opsonophagocytosis of bacteria. Antibody-based therapies, when coupled with immune modulators, such as P4 peptide, may be an effective tool together with antibiotics in our armamentarium against severe pneumonia.
C1 [Weeks, Jenni N.; McCullers, Jonathan A.] St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA.
[Boyd, Kelli L.] Vanderbilt Univ, Dept Pathol, Div Comparat Med, Nashville, TN USA.
[Rajam, Gowrisankar; Ades, Edwin W.] Ctr Dis Control & Prevent, Div Bacterial Dis, Atlanta, GA USA.
RP McCullers, JA (reprint author), St Jude Childrens Hosp, Dept Infect Dis, 262 Danny Thomas Pl, Memphis, TN 38105 USA.
EM jon.mccullers@stjude.org
FU public health service [AI-76816]; ALSAC; Centers for Disease Control and
Prevention
FX This work was supported by public health service grant AI-76816, ALSAC,
and the Centers for Disease Control and Prevention.
NR 25
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U1 0
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD MAY
PY 2011
VL 55
IS 5
BP 2276
EP 2281
DI 10.1128/AAC.00057-11
PG 6
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 756NM
UT WOS:000290019200057
PM 21383090
ER
PT J
AU Cuthbert, JP
Corrigan, JD
Harrison-Felix, C
Coronado, V
Dijkers, MP
Heinemann, AW
Whiteneck, GG
AF Cuthbert, Jeffrey P.
Corrigan, John D.
Harrison-Felix, Cynthia
Coronado, Victor
Dijkers, Marcel P.
Heinemann, Allen W.
Whiteneck, Gale G.
TI Factors That Predict Acute Hospitalization Discharge Disposition for
Adults With Moderate to Severe Traumatic Brain Injury
SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
LA English
DT Article
DE Brain injuries; Healthcare disparities; Hospitalization; Nursing homes,
Patient discharge; Rehabilitation; Rehabilitation centers
ID MODEL SYSTEMS; HEAD-INJURY; ACUTE-CARE; OUTCOMES; MORTALITY; OLDER;
INSURANCE; ACCESS; HEALTH; AGE
AB Objective: To identify factors predicting acute hospital discharge disposition after moderate to severe traumatic brain injury (TBI).
Design: Secondary analysis of existing datasets.
Setting: Acute care hospitals.
Participants: Adults hospitalized with moderate to severe TBI included in 3 large sets of archival data: (1) Centers for Disease Control and Prevention Central Nervous System Injury Surveillance database (n=15,646); (2) the National Trauma Data Bank (n=52,012); and (3) the National Study on the Costs and Outcomes of Trauma (n=1286).
Interventions: None.
Main Outcome Measure: Discharge disposition from acute hospitalization to 1 of 3 postacute settings: (1) home, (2) inpatient rehabilitation, or (3) subacute settings, including nursing homes and similar facilities.
Results: The Glasgow Coma Scale (GCS) score and length of acute hospital length of stay (LOS) accounted for 35% to 44% of the variance in discharges to home versus not home, while age and sex added from 5% to 8%, and race/ethnicity and hospitalization payment source added another 2% to 5%. When predicting discharge to rehabilitation versus subacute care for those not going home, GCS and LOS accounted for 2% to 4% of the variance, while age and sex added 7% to 31%, and race/ethnicity and payment source added 4% to 5%. Across the datasets, longer LOS, older age, and white race increased the likelihood of not being discharged home; the most consistent predictor of discharge to rehabilitation was younger age.
Conclusions: The decision to discharge to home a person with moderate to severe TBI appears to be based primarily on severity-related factors. In contrast, the decision to discharge to rehabilitation rather than to subacute care appears to reflect sociobiologic and socioeconomic factors; however, generalizability of these results is limited by the restricted range of potentially important variables available for analysis.
C1 [Cuthbert, Jeffrey P.; Harrison-Felix, Cynthia; Whiteneck, Gale G.] Craig Hosp, Res Dept, Englewood, CO USA.
[Corrigan, John D.] Ohio State Univ, Dept Phys Med & Rehabil, Columbus, OH 43210 USA.
[Coronado, Victor] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA.
[Dijkers, Marcel P.] Mt Sinai Sch Med, Dept Rehabil Med, New York, NY USA.
[Heinemann, Allen W.] Northwestern Univ, Dept Phys Med & Rehabil, Feinberg Sch Med, Chicago, IL 60611 USA.
[Heinemann, Allen W.] Rehabil Inst Chicago, Chicago, IL 60611 USA.
RP Cuthbert, JP (reprint author), 3425 S Clarkson St, Englewood, CO 80113 USA.
EM JCuthbert@Craighospital.org
RI Corrigan, John/E-2921-2011; Heinemann, Allen /K-6283-2012;
OI Heinemann, Allen /0000-0003-2782-7326; Dijkers,
Marcel/0000-0002-8362-5596
FU National Institute on Disability and Rehabilitation Research, Office of
Special Education and Rehabilitative Services, U.S. Department of
Education [H133A060038]; Traumatic Brain Injury Model System Centers
[H133A070022]; Ohio State University [H133A070029]; Mount Sinai Medical
Center [H133A070033]; Rehabilitation Institute of Chicago [H133A080045]
FX Supported by a supplemental grant to the Traumatic Brain Injury Model
Systems National Data and Statistical Center from the National Institute
on Disability and Rehabilitation Research, Office of Special Education
and Rehabilitative Services, U.S. Department of Education (grant no.
H133A060038): and Traumatic Brain Injury Model System Centers grants to
Craig Hospital (grant no. H133A070022), Ohio State University (grant no.
H133A070029), Mount Sinai Medical Center (grant no. H133A070033), and
the Rehabilitation Institute of Chicago (grant no. H133A080045).
NR 41
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U1 2
U2 15
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0003-9993
J9 ARCH PHYS MED REHAB
JI Arch. Phys. Med. Rehabil.
PD MAY
PY 2011
VL 92
IS 5
BP 721
EP 730
DI 10.1016/j.apmr.2010.12.023
PG 10
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA 759YO
UT WOS:000290288000005
PM 21530719
ER
PT J
AU Antonini, JM
Roberts, JR
Stone, S
Chen, BT
Schwegler-Berry, D
Chapman, R
Zeidler-Erdely, PC
Andrews, RN
Frazer, DG
AF Antonini, James M.
Roberts, Jenny R.
Stone, Samuel
Chen, Bean T.
Schwegler-Berry, Diane
Chapman, Rebecca
Zeidler-Erdely, Patti C.
Andrews, Ronnee N.
Frazer, David G.
TI Persistence of deposited metals in the lungs after stainless steel and
mild steel welding fume inhalation in rats
SO ARCHIVES OF TOXICOLOGY
LA English
DT Article
DE Welding fume; Inhalation; Lung burden; Lung clearance; Pulmonary
toxicity
ID SPRAGUE-DAWLEY RATS; DEFENSE RESPONSES; INTRATRACHEAL INSTILLATION;
BACTERIAL-INFECTION; MANGANESE EXPOSURE; PULMONARY-FUNCTION; WELDERS;
INFLAMMATION; FIBROSIS; RECOVERY
AB Welding generates complex metal fumes that vary in composition. The objectives of this study were to compare the persistence of deposited metals and the inflammatory potential of stainless and mild steel welding fumes, the two most common fumes used in US industry. Sprague-Dawley rats were exposed to 40 mg/m(3) of stainless or mild steel welding fumes for 3 h/day for 3 days. Controls were exposed to filtered air. Generated fume was collected, and particle size and elemental composition were determined. Bronchoalveolar lavage was done on days 0, 8, 21, and 42 after the last exposure to assess lung injury/inflammation and to recover lung phagocytes. Non-lavaged lung samples were analyzed for total and specific metal content as a measure of metal persistence. Both welding fumes were similar in particle morphology and size. Following was the chemical composition of the fumes-stainless steel: 57% Fe, 20% Cr, 14% Mn, and 9% Ni; mild steel: 83% Fe and 15% Mn. There was no effect of the mild steel fume on lung injury/inflammation at any time point compared to air control. Lung injury and inflammation were significantly elevated at 8 and 21 days after exposure to the stainless steel fume compared to control. Stainless steel fume exposure was associated with greater recovery of welding fume-laden macrophages from the lungs at all time points compared with the mild steel fume. A higher concentration of total metal was observed in the lungs of the stainless steel welding fume at all time points compared with the mild steel fume. The specific metals present in the two fumes were cleared from the lungs at different rates. The potentially more toxic metals (e.g., Mn, Cr) present in the stainless steel fume were cleared from the lungs more quickly than Fe, likely increasing their translocation from the respiratory system to other organs.
C1 [Antonini, James M.; Roberts, Jenny R.; Stone, Samuel; Chen, Bean T.; Schwegler-Berry, Diane; Chapman, Rebecca; Zeidler-Erdely, Patti C.; Frazer, David G.] NIOSH, Hlth Effects Lab Div, Morgantown, WV 26505 USA.
[Andrews, Ronnee N.] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45213 USA.
RP Antonini, JM (reprint author), NIOSH, Hlth Effects Lab Div, 1095 Willowdale Rd,Mailstop 2015, Morgantown, WV 26505 USA.
EM jga6@cdc.gov
FU National Institute for Occupational Safety and Health (NIOSH); National
Occupational Research Agenda (NORA)
FX The authors thank Amy Moseley, Jared Cumpston, and Donny Leonard from
the inhalation exposure team for their expert technical assistance
during the project. Funding for the project was provided by the National
Institute for Occupational Safety and Health (NIOSH) and the National
Occupational Research Agenda (NORA). The authors also thank the National
Toxicology Program for additional support during the development of the
welding fume generator and exposure system.
NR 38
TC 19
Z9 19
U1 1
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5761
J9 ARCH TOXICOL
JI Arch. Toxicol.
PD MAY
PY 2011
VL 85
IS 5
BP 487
EP 498
DI 10.1007/s00204-010-0601-1
PG 12
WC Toxicology
SC Toxicology
GA 760IU
UT WOS:000290318800004
PM 20924559
ER
PT J
AU Wu, CK
Chang, MH
Lin, JW
Caffrey, JL
Lin, YS
AF Wu, Cho-Kai
Chang, Man-Huei
Lin, Jou-Wei
Caffrey, James L.
Lin, Yu-Sheng
TI Renal-related biomarkers and long-term mortality in the US subjects with
different coronary risks
SO ATHEROSCLEROSIS
LA English
DT Article
DE Kidney function tests; Biological markers; Risk assessment; Nutrition
surveys
ID CHRONIC KIDNEY-DISEASE; ALL-CAUSE MORTALITY; CYSTATIN-C; CARDIOVASCULAR
EVENTS; COMMUNITY; ADULTS; DEATH
AB Objective: The objective was to evaluate the association of a panel of renal biomarkers with long-term mortalities.
Methods: Participants in the Third National Health and Nutrition Examination Survey (NHANES III) aged 35 years and above were included and Framingham risk scores were calculated. Renal-related biomarkers, including creatinine-based estimated glomerular filtration rate (eGFR), cystatin C, uric acid, C-reactive protein (CRP), fibrinogen, urinary cadmium, albuminuria, homocysteine, and vitamin D were tested by Cox-regression model for their association with all-cause, cardiovascular (CV), and non-CV mortality obtained from the 2006 NHANES III-linked follow-up data, stratified by sex and Framingham risk.
Results: In the 4873 men and 5372 women, 36.3%, 28.1%, and 35.6% of men and 67.2%, 25.8%, and 7.0% of women were classified into low-, intermediate-, and high coronary risk groups. With an average follow-up of 13.2 years, a total of 3632 deaths and 1657 CV deaths were recorded. Albuminuria was associated with all-cause mortality in both sexes across coronary risk groups. Creatinine-based eGFR provided additional differential capacity only in the women with intermediate-to-high coronary risk. Cystatin C was associated with all-cause mortality in the men with intermediate-to-high coronary risk and with CV mortality in the women with low coronary risk. Urinary cadmium was positively related to non-CV mortality. High vitamin D was protective against cardiovascular mortality in a limited category of men and women.
Conclusions: Albuminuria is associated with long-term all-cause mortalities independent of Framingham risks. Adding the panel of renal biomarkers provides limited advantages for predicting risk when compared to FRS alone. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Wu, Cho-Kai; Lin, Jou-Wei] Natl Taiwan Univ Hosp, Yun Lin Branch, Ctr Cardiovasc, Dou Liou, Yun Lin, Taiwan.
[Wu, Cho-Kai; Lin, Jou-Wei] Natl Taiwan Univ Hosp, Yun Lin Branch, Hlth Management Ctr, Dou Liou, Yun Lin, Taiwan.
[Wu, Cho-Kai; Lin, Jou-Wei] Natl Taiwan Univ, Coll Med, Dept Med, Taipei 10764, Taiwan.
[Chang, Man-Huei] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA USA.
[Caffrey, James L.] Univ N Texas, Hlth Sci Ctr, Dept Integrat Physiol, Ft Worth, TX USA.
[Caffrey, James L.] Univ N Texas, Hlth Sci Ctr, Cardiovasc Res Inst, Ft Worth, TX USA.
[Lin, Yu-Sheng] Univ N Texas, Hlth Sci Ctr, Dept Environm & Occupat Hlth, Ft Worth, TX USA.
RP Lin, JW (reprint author), Natl Taiwan Univ Hosp, Yun Lin Branch, Ctr Cardiovasc, Dou Liou, Yun Lin, Taiwan.
EM jouweilin@yahoo.com; Yu-Sheng.Lin@unthsc.edu
OI WU, CHO-KAI/0000-0002-3867-150X
FU University of North Texas Health Science Center at Fort Worth [G62024];
National Taiwan University Hospital Yun-Lin Branch [98.X002, 99.X004]
FX This work was in part supported by the G62024 Interdisciplinary Research
Grant from the University of North Texas Health Science Center at Fort
Worth and by the grants from National Taiwan University Hospital Yun-Lin
Branch (98.X002 and 99.X004).
NR 30
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U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0021-9150
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAY
PY 2011
VL 216
IS 1
BP 226
EP 236
DI 10.1016/j.atherosclerosis.2011.01.046
PG 11
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA 758YV
UT WOS:000290205800037
PM 21371709
ER
PT J
AU White, A
Vernon, SW
Franzini, L
Du, XLL
AF White, Arica
Vernon, Sally W.
Franzini, Luisa
Du, Xianglin L.
TI Racial and Ethnic Disparities in Colorectal Cancer Screening Persisted
Despite Expansion of Medicare's Screening Reimbursement
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID HEALTH INTERVIEW SURVEY; UNITED-STATES; POPULATION; ENROLLEES; TRENDS;
GENERALIZABILITY; BENEFICIARIES; EPIDEMIOLOGY; COVERAGE; PROSTATE
AB Objective: We examined the effect of Medicare's expansion of colorectal cancer (CRC) screening test reimbursement on racial/ethnic disparities in CRC screening.
Methods: CRC screening was ascertained for Medicare beneficiaries (n = 30,893), aged 70 to 89, who had no history of any tumor and resided in 16 Surveillance, Epidemiology and End Results regions of the United States from 1996 to 2005. CRC screening tests were identified in the 5% sample of Medicare claims. Age-gender-adjusted percentages and -adjusted odds of receiving any guideline-specific CRC screening [i.e., annual fecal occult blood test (FOBT), sigmoidoscopy every 5 years or colonoscopy every 10 years] by race/ethnicity and Medicare coverage expansion period (i.e., prior to FOBT coverage, FOBT coverage only, and post-colonoscopy coverage) were reported.
Results: CRC screening increased as Medicare coverage expanded for white and black Medicare beneficiaries. However, blacks were less likely than whites to receive screening prior to FOBT coverage (OR = 0.74, 95% CI: 0.61-0.90), during FOBT coverage only (OR = 0.66, 95% CI: 0.52-0.83) and after colonoscopy coverage (OR = 0.80, 95% CI: 0.68-0.95). Hispanics were less likely to receive screening after colonoscopy coverage (OR = 0.73, 95% CI: 0.54-0.99).
Conclusions: Despite the expansion of Medicare coverage for CRC screening tests, racial/ethnic differences in CRC screening persisted over time in this universally insured population, especially for blacks and Hispanics. Future studies should explore other factors beyond health insurance that may contribute to screening disparities in this and younger populations.
Impact: Although CRC screening rates increased over time, they were still low according to recommendations. More effort is needed to increase CRC screening among all Medicare beneficiaries. Cancer Epidemiol Biomarkers Prev; 20(5); 811-7. (C)2011 AACR.
C1 [White, Arica; Du, Xianglin L.] Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Div Epidemiol, Houston, TX USA.
[Vernon, Sally W.] Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Div Hlth Promot & Behav Sci, Houston, TX USA.
[Franzini, Luisa] Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Div Management Policy & Community Hlth, Houston, TX USA.
RP White, A (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, Epidemiol & Appl Res Branch, 4770 Buford Hwy NE,Mailstop K55, Atlanta, GA 30341 USA.
EM awhite5@cdc.gov
FU Agency for Healthcare Research and Quality (AHRQ) [R01-HS016743];
University of Texas School of Public Health; National Cancer Institute
[R25CA57712]
FX This study was supported by a grant from the Agency for Healthcare
Research and Quality (AHRQ) (R01-HS016743). Dr. Arica White was
supported by a pre-doctoral fellowship from the University of Texas
School of Public Health Cancer Education and Career Development Program;
National Cancer Institute Grant R25CA57712.
NR 34
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U1 0
U2 1
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD MAY
PY 2011
VL 20
IS 5
BP 811
EP 817
DI 10.1158/1055-9965.EPI-09-0963
PG 7
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA 759MU
UT WOS:000290251000012
PM 21546366
ER
PT J
AU Saile, E
Boons, GJ
Buskas, T
Carlson, RW
Kannenberg, EL
Barr, JR
Boyer, AE
Gallegos-Candela, M
Quinn, CP
AF Saile, Elke
Boons, Geert-Jan
Buskas, Therese
Carlson, Russell W.
Kannenberg, Elmar L.
Barr, John R.
Boyer, Anne E.
Gallegos-Candela, Maribel
Quinn, Conrad P.
TI Antibody Responses to a Spore Carbohydrate Antigen as a Marker of
Nonfatal Inhalation Anthrax in Rhesus Macaques
SO CLINICAL AND VACCINE IMMUNOLOGY
LA English
DT Article
ID BACILLUS-ANTHRACIS; BIOSYNTHETIC OPERON; PROTECTIVE ANTIGEN; POSTAL
WORKERS; UNITED-STATES; WASHINGTON; EXOSPORIUM; DC; TETRASACCHARIDE;
GLYCOPROTEIN
AB The Bacillus anthracis exosporium protein BclA contains an O-linked antigenic tetrasaccharide whose terminal sugar is known as anthrose (J. M. Daubenspeck et al., J. Biol. Chem. 279: 30945-30953, 2004). We hypothesized that serologic responses to anthrose may have diagnostic value in confirming exposure to aerosolized B. anthracis. We evaluated the serologic responses to a synthetic anthrose-containing trisaccharide (ATS) in a group of five rhesus macaques that survived inhalation anthrax following exposure to B. anthracis Ames spores. Two of five animals (RM2 and RM3) were treated with ciprofloxacin starting at 48 hours postexposure and two (RM4 and RM5) at 72 h postexposure; one animal (RM1) was untreated. Infection was confirmed by blood culture and detection of anthrax toxin lethal factor (LF) in plasma. Anti-ATS IgG responses were determined at 14, 21, 28, and 35 days postexposure, with preexposure serum as a control. All animals, irrespective of ciprofloxacin treatment, mounted a specific, measurable anti-ATS IgG response. The earliest detectable responses were on days 14 (RM1, RM2, and RM5), 21 (RM4), and 28 (RM3). Specificity of the anti-ATS responses was demonstrated by competitive-inhibition enzyme immunoassay (CIEIA), in which a 2-fold (wt/wt) excess of carbohydrate in a bovine serum albumin (BSA) conjugate of the oligosaccharide (ATS-BSA) effected > 94% inhibition, whereas a structural analog lacking the 3-hydroxy-3-methyl-butyryl moiety at the C-4 '' of the anthrosyl residue had no inhibition activity. These data suggest that anti-ATS antibody responses may be used to identify aerosol exposure to B. anthracis spores. The anti-ATS antibody responses were detectable during administration of ciprofloxacin.
C1 [Saile, Elke] Ctr Dis Control & Prevent, MPIR Lab, NCIRD, DBD,MVPDB, Atlanta, GA 30333 USA.
[Boons, Geert-Jan; Buskas, Therese; Carlson, Russell W.; Kannenberg, Elmar L.] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA.
[Barr, John R.; Boyer, Anne E.; Gallegos-Candela, Maribel] Natl Ctr Environm Hlth, Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
[Kannenberg, Elmar L.] Univ Tubingen, Dept Microbiol & Biotechnol, D-72076 Tubingen, Germany.
[Gallegos-Candela, Maribel] Ctr Dis Control & Prevent, Battelle Mem Inst, Atlanta, GA 30341 USA.
RP Saile, E (reprint author), Ctr Dis Control & Prevent, MPIR Lab, NCIRD, DBD,MVPDB, 1600 Clifton Rd,MS D-01, Atlanta, GA 30333 USA.
EM ESaile@cdc.gov
RI Boons, Geert-Jan/J-3211-2016
OI Boons, Geert-Jan/0000-0003-3111-5954
FU NIAID [R21 AI059577]; NIH [GM065248]; DOE [DE-FG02-93ER20097]; Atlanta
Research and Education Foundation (AREF), Atlanta, GA; Battelle
Biomedical Research Center, Columbus, OH [SPO700-00-D-3180]; Biomedical
Advance Research and Development Authority (BARDA)
FX This work was supported by NIAID grant R21 AI059577 (to R.W.C.), by NIH
grant GM065248 (to G.-J.B.), and in part by DOE grant DE-FG02-93ER20097
(to the CCRC). E.S. was funded in part through the Atlanta Research and
Education Foundation (AREF), Atlanta, GA. Part of the work was performed
by Battelle Biomedical Research Center, Columbus, OH, under contract
SPO700-00-D-3180. We also gratefully acknowledge funding support from
the Biomedical Advance Research and Development Authority (BARDA).
NR 37
TC 10
Z9 10
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1556-6811
J9 CLIN VACCINE IMMUNOL
JI Clin. Vaccine Immunol.
PD MAY
PY 2011
VL 18
IS 5
BP 743
EP 748
DI 10.1128/CVI.00475-10
PG 6
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 758IB
UT WOS:000290156600007
PM 21389148
ER
PT J
AU Porwancher, RB
Hagerty, CG
Fan, JQ
Landsberg, L
Johnson, BJB
Kopnitsky, M
Steere, AC
Kulas, K
Wong, SJ
AF Porwancher, Richard B.
Hagerty, C. Greg
Fan, Jianqing
Landsberg, Lisa
Johnson, Barbara J. B.
Kopnitsky, Mark
Steere, Allen C.
Kulas, Karen
Wong, Susan J.
TI Multiplex Immunoassay for Lyme Disease Using VlsE1-IgG and pepC10-IgM
Antibodies: Improving Test Performance through Bioinformatics
SO CLINICAL AND VACCINE IMMUNOLOGY
LA English
DT Article
ID LINKED-IMMUNOSORBENT-ASSAY; BORRELIA-BURGDORFERI; SERODIAGNOSIS;
CLASSIFICATION; DIAGNOSIS; PEPTIDE; VLSE; REGRESSION; ACCURACY; CRITERIA
AB The Centers for Disease Control and Prevention currently recommends a 2-tier serologic approach to Lyme disease laboratory diagnosis, comprised of an initial serum enzyme immunoassay (EIA) for antibody to Borrelia burgdorferi followed by supplementary IgG and IgM Western blotting of EIA-positive or -equivocal samples. Western blot accuracy is limited by subjective interpretation of weakly positive bands, false-positive IgM immunoblots, and low sensitivity for detection of early disease. We developed an objective alternative second-tier immunoassay using a multiplex microsphere system that measures VlsE1-IgG and pepC10-IgM antibodies simultaneously in the same sample. Our study population comprised 79 patients with early acute Lyme disease, 82 patients with early-convalescent-phase disease, 47 patients with stage II and III disease, 34 patients post-antibiotic treatment, and 794 controls. A bioinformatic technique called partial receiver-operator characteristic (ROC) regression was used to combine individual antibody levels into a single diagnostic score with a single cutoff; this technique enhances test performance when a high specificity is required (e. g., >= 95%). Compared to Western blotting, the multiplex assay was equally specific (95.6%) but 20.7% more sensitive for early-convalescent-phase disease (89.0% versus 68.3%, respectively; 95% confidence interval [95% CI] for difference, 12.1% to 30.9%) and 12.5% more sensitive overall (75.0% versus 62.5%, respectively; 95% CI for difference, 8.1% to 17.1%). As a second-tier test, a multiplex assay for VlsE1-IgG and pepC10-IgM antibodies performed as well as or better than Western blotting for Lyme disease diagnosis. Prospective validation studies appear to be warranted.
C1 [Porwancher, Richard B.; Landsberg, Lisa] Infect Dis Consultants PC, Mercerville, NJ 08619 USA.
[Porwancher, Richard B.; Hagerty, C. Greg] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Med, Piscataway, NJ 08854 USA.
[Fan, Jianqing] Princeton Univ, Dept Operat Res & Financial Engn, Princeton, NJ 08544 USA.
[Johnson, Barbara J. B.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA.
[Kopnitsky, Mark] Zeus Sci Inc, Branchburg, NJ USA.
[Steere, Allen C.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol, Boston, MA USA.
[Kulas, Karen; Wong, Susan J.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA.
RP Porwancher, RB (reprint author), Infect Dis Consultants PC, 1245 Whitehorse Mercerville Rd,Suite 411, Mercerville, NJ 08619 USA.
EM porwancher@aol.com
FU SBIR-AT-NIAID [1R43AI069564-01, -01S1]; National Institute of Allergy
and Infectious Diseases, National Institutes of Health; Zeus Scientific,
Inc., to Health Research, Inc., Menands, NY
FX Financial support was provided by SBIR-AT-NIAID grants 1R43AI069564-01
and -01S1 to Infectious Disease Consultants, PC, from the National
Institute of Allergy and Infectious Diseases, National Institutes of
Health, and by a grant from Zeus Scientific, Inc., to Health Research,
Inc., Menands, NY, a nonprofit organization which supported the work
performed by S.J.W. and K.K. at the NYSDOH, Albany, NY, for this study.
NR 41
TC 18
Z9 19
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 1556-6811
J9 CLIN VACCINE IMMUNOL
JI Clin. Vaccine Immunol.
PD MAY
PY 2011
VL 18
IS 5
BP 851
EP 859
DI 10.1128/CVI.00409-10
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 758IB
UT WOS:000290156600022
PM 21367982
ER
PT J
AU Boobis, A
Budinsky, R
Collie, S
Crofton, K
Embry, M
Felter, S
Hertzberg, R
Kopp, D
Mihlan, G
Mumtaz, M
Price, P
Solomon, K
Teuschler, L
Yang, R
Zaleski, R
AF Boobis, Alan
Budinsky, Robert
Collie, Shanna
Crofton, Kevin
Embry, Michelle
Felter, Susan
Hertzberg, Richard
Kopp, David
Mihlan, Gary
Mumtaz, Moiz
Price, Paul
Solomon, Keith
Teuschler, Linda
Yang, Raymond
Zaleski, Rosemary
TI Critical analysis of literature on low-dose synergy for use in screening
chemical mixtures for risk assessment
SO CRITICAL REVIEWS IN TOXICOLOGY
LA English
DT Review
DE Chemical mixtures; low dose; risk assessment; synergy; TTC
ID AROMATIC-HYDROCARBONS; HETEROCYCLIC AMINES; FOCI DEVELOPMENT; TERNARY
MIXTURE; HEALTH-RISK; TOXICOLOGY; RATS; CARCINOGENICITY; ENHANCEMENT;
COMBINATION
AB There is increasing interest in the use of tiered approaches in risk assessment of mixtures or co-exposures to chemicals for prioritization. One possible screening-level risk assessment approach is the threshold of toxicological concern (TTC). To date, default assumptions of dose or response additivity have been used to characterize the toxicity of chemical mixtures. Before a screening-level approach could be used, it is essential to know whether synergistic interactions can occur at low, environmentally relevant exposure levels. Studies demonstrating synergism in mammalian test systems were identified from the literature, with emphasis on studies performed at doses close to the points of departure (PODs) for individual chemicals. This search identified 90 studies on mixtures. Few included quantitative estimates of low-dose synergy; calculations of the magnitude of interaction were included in only 11 papers. Quantitative methodology varied across studies in terms of the null hypothesis, response measured, POD used to test for synergy, and consideration of the slope of the dose-response curve. It was concluded that consistent approaches should be applied for quantification of synergy, including that synergy be defined in terms of departure from dose additivity; uniform procedures be developed for assessing synergy at low exposures; and the method for determining the POD for calculating synergy be standardized. After evaluation of the six studies that provided useful quantitative estimates of synergy, the magnitude of synergy at low doses did not exceed the levels predicted by additive models by more than a factor of 4.
C1 [Embry, Michelle] ILSI Hlth & Environm Sci Inst, Washington, DC 20005 USA.
[Boobis, Alan] Univ London Imperial Coll Sci Technol & Med, London, England.
[Budinsky, Robert; Price, Paul] Dow Chem Co USA, Midland, MI 48674 USA.
[Collie, Shanna] Synergy Toxicol, Boerne, TX USA.
[Crofton, Kevin] US EPA, Res Triangle Pk, NC 27711 USA.
[Felter, Susan] Procter & Gamble Co, Cincinnati, OH USA.
[Hertzberg, Richard; Kopp, David] Emory Univ, Atlanta, GA 30322 USA.
[Mihlan, Gary] Bayer CropSci, Res Triangle Pk, NC USA.
[Mumtaz, Moiz] Ctr Dis Control, Agcy Tox Subst & Dis Registry, Atlanta, GA 30333 USA.
[Solomon, Keith] Univ Guelph, Guelph, ON N1G 2W1, Canada.
[Teuschler, Linda] US EPA, Cincinnati, OH 45268 USA.
[Yang, Raymond] Colorado State Univ, Ft Collins, CO 80523 USA.
[Zaleski, Rosemary] ExxonMobil Biomed Sci Inc, Annandale, NJ USA.
RP Embry, M (reprint author), ILSI Hlth & Environm Sci Inst, Washington, DC 20005 USA.
EM membry@ilsi.org
RI Crofton, Kevin/J-4798-2015;
OI Crofton, Kevin/0000-0003-1749-9971; Boobis, Alan/0000-0003-3371-386X
FU HESI Mixtures Committee
FX The employment affiliations of the authors are shown on the cover page.
These individuals had the sole responsibility for the writing and
content of the paper. The individual authors worked as professionals in
preparing the article and not as agents of their employers. The
literature review used as the basis of this article was performed by
three of the authors (R. H., S. C., and D. K.) and funded by the HESI
Mixtures Committee, which collects funding from member companies to
support the project. Four of the authors (A. B., D. K., K. S., and R.Y.)
are affiliated with universities, two authors (R. H. and S. C.) are
independent consultants providing services to public and private
organizations, three of the authors* are affiliated with government
agencies, one author (M. E.) is affiliated with a nonprofit organization
and six of the authors (R. B., S. F., G. M., P. P., and R.Z.) are
employed by private corporations. Government and academic committee
participants were reimbursed for travel expenses to attend committee
meetings and did not receive any other compensation. (*The views
expressed in this paper are those of the authors and do not necessarily
reflect the opinions or policy of the US EPA or the Centers for Disease
Control, ATSDR.)
NR 42
TC 50
Z9 52
U1 5
U2 40
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1040-8444
J9 CRIT REV TOXICOL
JI Crit. Rev. Toxicol.
PD MAY
PY 2011
VL 41
IS 5
BP 369
EP 383
DI 10.3109/10408444.2010.543655
PG 15
WC Toxicology
SC Toxicology
GA 760MX
UT WOS:000290329500001
PM 21309635
ER
PT J
AU Shrestha, SS
Zhang, P
Albright, A
Imperatore, G
AF Shrestha, Sundar S.
Zhang, Ping
Albright, Ann
Imperatore, Giuseppina
TI Medical Expenditures Associated With Diabetes Among Privately Insured
U.S. Youth in 2007
SO DIABETES CARE
LA English
DT Article
ID HEALTH-CARE COSTS; CLINICAL CHARACTERISTICS; UNITED-STATES; US YOUTH;
SEARCH; PREVALENCE; TYPE-1; POPULATION; PREDICTORS; MELLITUS
AB OBJECTIVE-To estimate, among privately insured youth in the U.S., medical expenditures associated with diabetes and the difference in medical expenditures between individuals with insulin-treated diabetes mellitus (ITDM) and with non-ITDM (NITDM).
RESEARCH DESIGN AND METHODS-Using the 2007 Market Scan commercial claims and encounter database, we analyzed data for 49,356 youth (aged <= 19 years) who were continuously enrolled in fee-for-service health plans. Youth with diabetes (cases) were identified from inpatient, outpatient, and pharmaceutical drug claims. Each case was matched with five controls (without diabetes) by age (+/- 2 years), sex, census region, and urban versus rural residence. We used regression models to estimate medical expenditures in total and by component (inpatient, outpatient, and medication).
RESULTS-The predicted mean annual total per-person medical expenditures were $9,061 for youth with diabetes and $1,468 for those without, an excess of $7,593 for those with diabetes; of which, 43% was for prescription drugs. The predicted mean annual total expenditures were $9,333 for ITDM youth and $5,683 for NITDM youth, respectively, an excess of $3,650 for those with ITDM diabetes, of which 59% was for prescription drugs.
CONCLUSIONS-The excess medical expenditures associated with diabetes, ITDM in particular, among youth are substantial. Our estimates of excess expenditures can be used to assess the economic burden of diabetes overall and by diabetes treatment mode. Our estimated excess expenditure for NITDM may be used for evaluating the economic efficiency of interventions aimed at preventing type 2 diabetes in U.S. youth.
C1 [Shrestha, Sundar S.; Zhang, Ping; Albright, Ann; Imperatore, Giuseppina] US Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA.
RP Shrestha, SS (reprint author), US Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA.
EM sshrestha@cdc.gov
NR 25
TC 17
Z9 17
U1 0
U2 5
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD MAY
PY 2011
VL 34
IS 5
BP 1097
EP 1101
DI 10.2337/dc10-2177
PG 5
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 761RV
UT WOS:000290419200008
PM 21525502
ER
PT J
AU McEwen, LN
Kim, C
Ettner, SL
Herman, WH
Karter, AJ
Beckles, GL
Brown, AF
AF McEwen, Laura N.
Kim, Catherine
Ettner, Susan L.
Herman, William H.
Karter, Andrew J.
Beckles, Gloria L.
Brown, Arleen F.
TI Competing Demands for Time and Self-Care Behaviors, Processes of Care,
and Intermediate Outcomes Among People With Diabetes Translating
Research Into Action for Diabetes (TRIAD)
SO DIABETES CARE
LA English
DT Article
ID HEALTH; CAREGIVERS; QUALITY; WOMEN; RISK
AB OBJECTIVE-To determine whether competing demands for time affect diabetes self-care behaviors, processes of care, and intermediate outcomes.
RESEARCH DESIGN AND METHODS-We used survey and medical record data from 5,478 participants in Translating Research Into Action for Diabetes (TRIAD) and hierarchical regression models to examine the cross-sectional associations between competing demands for time and diabetes outcomes, including self-management, processes of care, and intermediate health outcomes.
RESULTS-Fifty-two percent of participants reported no competing demands, 7% reported caregiving responsibilities only, 36% reported employment responsibilities only, and 6% reported both caregiving and employment responsibilities. For both women and men, employment responsibilities (with or without caregiving responsibilities) were associated with lower rates of diabetes self-care behaviors, worse processes of care, and, in men, worse HbA(1c).
CONCLUSIONS-Accommodations for competing demands for time may promote self-management and improve the processes and outcomes of care for employed adults with diabetes.
C1 [McEwen, Laura N.; Kim, Catherine; Herman, William H.] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
[Kim, Catherine] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA.
[Ettner, Susan L.; Brown, Arleen F.] Univ Calif Los Angeles, Dept Med, Div Gen Internal Med & Hlth Serv Res, Los Angeles, CA 90024 USA.
[Ettner, Susan L.] Univ Calif Los Angeles, Dept Hlth Serv, Los Angeles, CA USA.
[Herman, William H.] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA.
[Karter, Andrew J.] Kaiser Permanente, Div Res, Oakland, CA USA.
[Beckles, Gloria L.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA USA.
RP McEwen, LN (reprint author), Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
EM lmattei@med.umich.edu
FU Centers for Disease Control and Prevention (Division of Diabetes
Translation) [04005]; National Institute of Diabetes and Digestive and
Kidney Diseases
FX This study was jointly funded by Program Announcement Number 04005 from
the Centers for Disease Control and Prevention (Division of Diabetes
Translation) and the National Institute of Diabetes and Digestive and
Kidney Diseases. Significant contributions to this study were made by
members of the TRIAD Study Group.
NR 14
TC 4
Z9 4
U1 0
U2 1
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD MAY
PY 2011
VL 34
IS 5
BP 1180
EP 1182
DI 10.2337/dc10-2038
PG 3
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 761RV
UT WOS:000290419200022
PM 21464464
ER
PT J
AU Wells, EM
Navas-Acien, A
Herbstman, JB
Apelberg, BJ
Silbergeld, EK
Caldwell, KL
Jones, RL
Halden, RU
Witter, FR
Goldman, LR
AF Wells, Ellen M.
Navas-Acien, Ana
Herbstman, Julie B.
Apelberg, Benjamin J.
Silbergeld, Ellen K.
Caldwell, Kathleen L.
Jones, Robert L.
Halden, Rolf U.
Witter, Frank R.
Goldman, Lynn R.
TI Low-Level Lead Exposure and Elevations in Blood Pressure during
Pregnancy
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE benchmark dose; blood pressure; hypertension; lead; pregnancy; risk
assessment; umbilical cord
ID CARDIOVASCULAR-DISEASE; UNITED-STATES; CORD-BLOOD; INDUCED HYPERTENSION;
NATIONAL-HEALTH; RISK-ASSESSMENT; ASSOCIATION; BONE; EPIDEMIOLOGY;
PREECLAMPSIA
AB BACKGROUND: Lead exposure is associated with elevated blood pressure during pregnancy; however, the magnitude of this relationship at low exposure levels is unclear.
OBJECTIVES: Our goal was to determine the association between low-level lead exposure and blood pressure during late pregnancy.
METHODS: We collected admission and maximum (based on systolic) blood pressures during labor and delivery among 285 women in Baltimore, Maryland. We measured umbilical cord blood lead using inductively coupled plasma mass spectrometry. Multivariable models were adjusted for age, race, median household income, parity, smoking during pregnancy, prepregnancy body mass index, and anemia. These models were used to calculate benchmark dose values.
RESULTS: Geometric mean cord blood lead was 0.66 mu g/dL (95% confidence interval, 0.61-0.70). Comparing blood pressure measurements between those in the highest and those in the lowest quartile of lead exposure, we observed a 6.87-mmHg (1.51-12.21 mmHg) increase in admission systolic blood pressure and a 4.40-mmHg (0.21-8.59 mmHg) increase in admission diastolic blood pressure after adjustment for confounders. Corresponding values for maximum blood pressure increase were 7.72 (1.83-13.60) and 8.33 (1.14-15.53) mmHg. Benchmark dose lower limit values for a 1-SD increase in blood pressure were < 2 mu g/dL blood lead for all blood pressure end points.
CONCLUSIONS: A significant association between low-level lead exposures and elevations in maternal blood pressure during labor and delivery can be observed at umbilical blood lead levels < 2 mu g/dL.
C1 [Goldman, Lynn R.] George Washington Univ, Sch Publ Hlth & Hlth Serv, Washington, DC 20037 USA.
[Wells, Ellen M.] Case Western Reserve Univ, Sch Med, Dept Environm Hlth Sci, Cleveland, OH 44106 USA.
[Wells, Ellen M.; Navas-Acien, Ana; Silbergeld, Ellen K.; Halden, Rolf U.; Goldman, Lynn R.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA.
[Navas-Acien, Ana; Apelberg, Benjamin J.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
[Herbstman, Julie B.] Columbia Univ, Columbia Ctr Childrens Environm Hlth, Mailman Sch Publ Hlth, New York, NY USA.
[Caldwell, Kathleen L.; Jones, Robert L.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Halden, Rolf U.] Arizona State Univ, Biodesign Inst, Ctr Environm Biotechnol, Tempe, AZ USA.
[Witter, Frank R.] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Baltimore, MD 21205 USA.
RP Goldman, LR (reprint author), George Washington Univ, Sch Publ Hlth & Hlth Serv, 2300 Eye St NW,Suite 106, Washington, DC 20037 USA.
EM sphlrg@gwumc.edu
RI Goldman, Lynn/D-5372-2012; Halden, Rolf/F-9562-2010;
OI Halden, Rolf/0000-0001-5232-7361; Wells, Ellen/0000-0002-7293-1395
FU Maryland Cigarette Restitution Program Research; National Institute for
Environmental Health Sciences (NIEHS) [1R01ES015445]; U.S. Environmental
Protection Agency (U.S. EPA) Science
FX This study received funding from the Maryland Cigarette Restitution
Program Research Grant, National Institute for Environmental Health
Sciences (NIEHS) grant 1R01ES015445, and the U.S. Environmental
Protection Agency (U.S. EPA) Science to Achieve Results (STAR)
fellowship program.
NR 48
TC 16
Z9 16
U1 0
U2 10
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAY
PY 2011
VL 119
IS 5
BP 664
EP 669
DI 10.1289/ehp.1002666
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 757MK
UT WOS:000290089800032
PM 21292600
ER
PT J
AU Mocarelli, P
Gerthoux, PM
Needham, LL
Patterson, DG
Limonta, G
Falbo, R
Signorini, S
Bertona, M
Crespi, C
Sarto, C
Scott, PK
Turner, WE
Brambilla, P
AF Mocarelli, Paolo
Gerthoux, Pier Mario
Needham, Larry L.
Patterson, Donald G., Jr.
Limonta, Giuseppe
Falbo, Rosanna
Signorini, Stefano
Bertona, Maria
Crespi, Carla
Sarto, Cecilia
Scott, Paul K.
Turner, Wayman E.
Brambilla, Paolo
TI Perinatal Exposure to Low Doses of Dioxin Can Permanently Impair Human
Semen Quality
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE breast-feeding; dioxin; environmental endocrine disrupters; human sperm
impairment; human sperm quality; perinatal exposure; reproductive
hormones; TCDD
ID SERTOLI-CELLS; YOUNG MEN; PRENATAL EXPOSURE; SPERM COUNTS; HUMAN TESTIS;
INHIBIN B; POPULATION; SERUM; SMOKING; SEVESO
AB BACKGROUND: In recent decades, young men in some industrialized areas have reportedly experienced a decrease in semen quality.
OBJECTIVE: We examined effects of perinatal dioxin exposure on sperm quality and reproductive hormones.
METHODS: We investigated sperm quality and hormone concentrations in 39 sons (mean age, 22.5 years) born between 1977 and 1984 to mothers exposed to dioxin after the accident in Seveso, Italy (1976), and 58 comparisons (mean age, 24.6 years) born to mothers exposed only to background dioxin. Maternal dioxin levels at conception were extrapolated from the concentrations measured in 1976 serum samples.
RESULTS: The 21 breast-fed sons whose exposed mothers had a median serum dioxin concentration as low as 19 ppt at conception had lower sperm concentration (36.3 vs. 86.3 million/mL; p = 0.002), total count (116.9 vs. 231.1; p = 0.02), progressive motility (35.8 vs. 44.2%; p = 0.03), and total motile count (38.7 vs. 98 million; p = 0.01) than did the 36 breast-fed comparisons. The 18 formula-fed exposed and the 22 formula-fed and 36 breast-fed comparisons (maternal dioxin background 10 ppt at conception) had no sperm-related differences. Follicle-stimulating hormone was higher in the breast-fed exposed group than in the breast-fed comparisons (4.1 vs. 2.63 IU/L; p = 0.03) or the formula-fed exposed (4.1 vs. 2.6 IU/L; p = 0.04), and inhibin B was lower (breast-fed exposed group, 70.2; breast-fed comparisons, 101.8 pg/mL, p = 0.01; formula-fed exposed, 99.9 pg/mL, p = 0.02).
CONCLUSIONS: In utero and lactational exposure of children to relatively low dioxin doses can permanently reduce sperm quality.
C1 [Mocarelli, Paolo; Gerthoux, Pier Mario; Limonta, Giuseppe; Falbo, Rosanna; Signorini, Stefano; Bertona, Maria; Crespi, Carla; Sarto, Cecilia; Brambilla, Paolo] Hosp Desio, Univ Dept Lab Med, Monza Brianza, Italy.
[Mocarelli, Paolo; Brambilla, Paolo] Univ Milano Bicocca, Sch Med, Milan, Italy.
[Needham, Larry L.; Patterson, Donald G., Jr.; Turner, Wayman E.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Patterson, Donald G., Jr.] EnviroSolut Consulting Inc, Jasper, GA USA.
[Scott, Paul K.] ChemRisk Inc, Pittsburgh, PA USA.
RP Mocarelli, P (reprint author), Univ Milano Bicocca, Dept Lab Med, Hosp Desio, Via Mazzini 1, I-20033 Desio, Italy.
EM mocarelli@uds.unimib.it
RI Needham, Larry/E-4930-2011
FU Regione Lombardia, Milano, Italy [2896]; Centers for Disease Control and
Prevention
FX This study was supported by grant 2896 from Regione Lombardia, Milano,
Italy, and by the Centers for Disease Control and Prevention.
NR 41
TC 68
Z9 72
U1 0
U2 19
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAY
PY 2011
VL 119
IS 5
BP 713
EP 718
DI 10.1289/ehp.1002134
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 757MK
UT WOS:000290089800040
PM 21262597
ER
PT J
AU Veluthoor, S
Kelsey, RG
Gonzalez-Hernandez, MP
Panella, N
Dolan, M
Karchesy, J
AF Veluthoor, Sheeba
Kelsey, Rick G.
Gonzalez-Hernandez, M. P.
Panella, Nicholas
Dolan, Marc
Karchesy, Joe
TI Composition of the heartwood essential oil of incense cedar (Calocedrus
decurrens Torr.)
SO HOLZFORSCHUNG
LA English
DT Article
DE Calocedrus decurrens; GC-MS; heartwood essential oil
ID IXODES-SCAPULARIS ACARI; ANTIMICROBIAL ACTIVITY; EXTRACTIVE COMPONENTS;
PHYTOPHTHORA-RAMORUM; YELLOW-CEDAR; CARVACROL; IXODIDAE
C1 [Karchesy, Joe] Oregon State Univ, Corvallis, OR 97331 USA.
[Veluthoor, Sheeba] SIAS, SCRAMM, Med Chem Lab, Malappurum 673633, Kerala, India.
[Kelsey, Rick G.] US Forest Serv, PNW Res Stn, Corvallis, OR 97331 USA.
[Gonzalez-Hernandez, M. P.] Univ Santiago de Compostela, Dept Crop Prod, Lugo 27002, Spain.
[Panella, Nicholas; Dolan, Marc] Ctr Dis Control & Prevent, Ft Collins, CO 80522 USA.
RP Karchesy, J (reprint author), Oregon State Univ, Corvallis, OR 97331 USA.
EM joe.karchesy@oregonstate.edu
OI Gonzalez-Hernandez, M.P./0000-0002-0519-1702
NR 18
TC 0
Z9 0
U1 3
U2 9
PU WALTER DE GRUYTER & CO
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0018-3830
J9 HOLZFORSCHUNG
JI Holzforschung
PD MAY
PY 2011
VL 65
IS 3
BP 333
EP 336
DI 10.1515/HF.2011.051
PG 4
WC Forestry; Materials Science, Paper & Wood
SC Forestry; Materials Science
GA 761EO
UT WOS:000290378900007
ER
PT J
AU Kohler, BA
Ward, E
McCarthy, BJ
Schymura, MJ
Ries, LAG
Eheman, C
Jemal, A
Anderson, RN
Ajani, UA
Edwards, BK
AF Kohler, Betsy A.
Ward, Elizabeth
McCarthy, Bridget J.
Schymura, Maria J.
Ries, Lynn A. G.
Eheman, Christie
Jemal, Ahmedin
Anderson, Robert N.
Ajani, Umed A.
Edwards, Brenda K.
TI Annual Report to the Nation on the Status of Cancer, 1975-2007,
Featuring Tumors of the Brain and Other Nervous System
SO JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Article
ID SERVICES TASK-FORCE; BREAST-CANCER; UNITED-STATES; PROSTATE-CANCER;
RISK-FACTORS; LUNG-CANCER; INCIDENCE RATES; RECENT TRENDS; ADULT GLIOMA;
ALLERGIC CONDITIONS
AB Background The American Cancer Society, the Centers for Disease Control and Prevention (CDC), the National Cancer Institute, and the North American Association of Central Cancer Registries (NAACCR) collaborate annually to provide updated information on cancer occurrence and trends in the United States. This year's report highlights brain and other nervous system (ONS) tumors, including nonmalignant brain tumors, which became reportable on a national level in 2004.
Methods Cancer incidence data were obtained from the National Cancer Institute, CDC, and NAACCR, and information on deaths was obtained from the CDC's National Center for Health Statistics. The annual percentage changes in age-standardized incidence and death rates (2000 US population standard) for all cancers combined and for the top 15 cancers for men and for women were estimated by joinpoint analysis of long-term (1992-2007 for incidence; 1975-2007 for mortality) trends and short-term fixed interval (1998-2007) trends. Analyses of malignant neuroepithelial brain and ONS tumors were based on data from 1980-2007; data on nonmalignant tumors were available for 2004-2007. All statistical tests were two-sided.
Results Overall cancer incidence rates decreased by approximately 1% per year; the decrease was statistically significant (P < .05) in women, but not in men, because of a recent increase in prostate cancer incidence. The death rates continued to decrease for both sexes. Childhood cancer incidence rates continued to increase, whereas death rates continued to decrease. Lung cancer death rates decreased in women for the first time during 20032007, more than a decade after decreasing in men. During 2004-2007, more than 213 500 primary brain and ONS tumors were diagnosed, and 35.8% were malignant. From 1987-2007, the incidence of neuroepithelial malignant brain and ONS tumors decreased by 0.4% per year in men and women combined.
Conclusions The decrease in cancer incidence and mortality reflects progress in cancer prevention, early detection, and treatment. However, major challenges remain, including increasing incidence rates and continued low survival for some cancers. Malignant and nonmalignant brain tumors demonstrate differing patterns of occurrence by sex, age, and race, and exhibit considerable biologic diversity. Inclusion of nonmalignant brain tumors in cancer registries provides a fuller assessment of disease burden and medical resource needs associated with these unique tumors.
C1 [Kohler, Betsy A.] N Amer Assoc Cent Canc Registries, Springfield, IL 62404 USA.
[Ward, Elizabeth; Jemal, Ahmedin] Amer Canc Soc, Surveillance & Hlth Policy Res Dept, Atlanta, GA 30329 USA.
[McCarthy, Bridget J.] Univ Illinois, Dept Epidemiol & Biostat, Chicago, IL USA.
[Schymura, Maria J.] New York State Canc Registry, Menands, NY USA.
[Ries, Lynn A. G.; Edwards, Brenda K.] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
[Eheman, Christie] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
[Anderson, Robert N.] Ctr Dis Control & Prevent, Div Vital Stat, Natl Ctr Hlth Stat, Hyattsville, MD USA.
RP Kohler, BA (reprint author), N Amer Assoc Cent Canc Registries, 2121 W White Oaks Dr,Ste B, Springfield, IL 62404 USA.
EM bkohler@naaccr.org
FU American Cancer Society; National Cancer Institute of the National
Institutes of Health; Centers for Disease Control and Prevention;
Central Brain Tumor Registry of the United States; North American
Association of Central Cancer Registries; National Cancer Institute
FX The American Cancer Society, the National Cancer Institute of the
National Institutes of Health, the Centers for Disease Control and
Prevention, the Central Brain Tumor Registry of the United States, and
the North American Association of Central Cancer Registries. Funding to
pay for the Open Access publication charges associated with the article
was provided by the National Cancer Institute.
NR 118
TC 292
Z9 302
U1 3
U2 25
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0027-8874
J9 J NATL CANCER I
JI J. Natl. Cancer Inst.
PD MAY
PY 2011
VL 103
IS 9
BP 714
EP 736
DI 10.1093/jnci/djr077
PG 23
WC Oncology
SC Oncology
GA 760IG
UT WOS:000290317400007
PM 21454908
ER
PT J
AU Shiels, MS
Pfeiffer, RM
Gail, MH
Hall, HI
Li, JM
Chaturvedi, AK
Bhatia, K
Uldrick, TS
Yarchoan, R
Goedert, JJ
Engels, EA
AF Shiels, Meredith S.
Pfeiffer, Ruth M.
Gail, Mitchell H.
Hall, H. Irene
Li, Jianmin
Chaturvedi, Anil K.
Bhatia, Kishor
Uldrick, Thomas S.
Yarchoan, Robert
Goedert, James J.
Engels, Eric A.
TI Cancer Burden in the HIV-Infected Population in the United States
SO JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; AIDS-RELATED MALIGNANCIES; ANTIRETROVIRAL
THERAPY; SURVEILLANCE DATA; KAPOSIS-SARCOMA; RISK-FACTORS; HAART ERA;
TRENDS; ADULTS; MEN
AB Background Effective antiretroviral therapy has reduced the risk of AIDS and dramatically prolonged the survival of HIV-infected people in the United States. Consequently, an increasing number of HIV-infected people are at risk of non-AIDS-defining cancers that typically occur at older ages. We estimated the annual number of cancers in the HIV-infected population, both with and without AIDS, in the United States.
Methods Incidence rates for individual cancer types were obtained from the HIV/AIDS Cancer Match Study by linking 15 HIV and cancer registries in the United States. Estimated counts of the US HIV-infected and AIDS populations were obtained from Centers for Disease Control and Prevention surveillance data. We obtained estimated counts of AIDS-defining (ie, Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer) and non-AIDS-defining cancers in the US AIDS population during 1991-2005 by multiplying cancer incidence rates and AIDS population counts, stratified by year, age, sex, race and ethnicity, transmission category, and AIDS-relative time. We tested trends in counts and standardized incidence rates using linear regression models. We multiplied overall cancer rates and HIV-only (HIV infected, without AIDS) population counts, available from 34 US states during 2004-2007, to estimate cancers in the HIV-only population. All statistical tests were two-sided.
Results The US AIDS population expanded fourfold from 1991 to 2005 (96 179 to 413 080) largely because of an increase in the number of people aged 40 years or older. During 1991-2005, an estimated 79 656 cancers occurred in the AIDS population. From 1991-1995 to 2001-2005, the estimated number of AIDS-defining cancers decreased by greater than threefold (34 587 to 10 325 cancers; P(trend) < .001), whereas non-AIDS-defining cancers increased by approximately threefold (3193 to 10 059 cancers; P(trend) < .001). From 1991-1995 to 2001-2005, estimated counts increased for anal (206 to 1564 cancers), liver (116 to 583 cancers), prostate (87 to 759 cancers), and lung cancers (875 to 1882 cancers), and Hodgkin lymphoma (426 to 897 cancers). In the HIV-only population in 34 US states, an estimated 2191 non-AIDS-defining cancers occurred during 2004-2007, including 454 lung, 166 breast, and 154 anal cancers.
Conclusions Over a 15-year period (1991-2005), increases in non-AIDS-defining cancers were mainly driven by growth and aging of the AIDS population. This growing burden requires targeted cancer prevention and treatment strategies.
C1 [Shiels, Meredith S.; Chaturvedi, Anil K.; Goedert, James J.; Engels, Eric A.] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD 20852 USA.
[Pfeiffer, Ruth M.; Gail, Mitchell H.] NCI, Biostat Branch, Div Canc Epidemiol & Genet, Rockville, MD 20852 USA.
[Hall, H. Irene; Li, Jianmin] Centers Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA.
[Bhatia, Kishor; Yarchoan, Robert] NCI, Off HIV & AIDS Malignancy, Bethesda, MD 20892 USA.
[Uldrick, Thomas S.] NCI, Ctr Canc Res, Bethesda, MD 20892 USA.
RP Shiels, MS (reprint author), NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS 7059, Rockville, MD 20852 USA.
EM shielsms@mail.nih.gov
RI Pfeiffer, Ruth /F-4748-2011; Chaturvedi, Anil/J-2024-2015
OI Chaturvedi, Anil/0000-0003-2696-8899
FU National Cancer Institute
FX Intramural Research Program of the National Cancer Institute.
NR 41
TC 261
Z9 262
U1 1
U2 12
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0027-8874
J9 J NATL CANCER I
JI J. Natl. Cancer Inst.
PD MAY
PY 2011
VL 103
IS 9
BP 753
EP 762
DI 10.1093/jnci/djr076
PG 10
WC Oncology
SC Oncology
GA 760IG
UT WOS:000290317400010
PM 21483021
ER
PT J
AU Edelson, PJ
Anderson, JA
AF Edelson, Paul J.
Anderson, Janelle A.
TI Reported Cases of Measles in International Air Travelers to the United
States, August 2005-March 2008
SO JOURNAL OF TRAVEL MEDICINE
LA English
DT Article
AB Methods. Airlines and state health departments report cases of suspected measles in international travelers to the Centers for Disease Control and Prevention Quarantine Stations. We reviewed these reports, maintained in an electronic database, to determine the demographic and epidemiologic characteristics of international air travelers infected with measles.
Results. We reviewed 35 confirmed cases of measles in air travelers and analyzed their demographic and epidemiologic characteristics. The median age of case travelers was 17 (range: 4 months-50 years). These travelers arrived from all regions of the world, including 10 countries with immunization rates of measles-containing vaccine below 90% and five others experiencing local outbreaks. Of 17 travelers for whom immunization status was known, 2 had been adequately immunized with at least two doses of a measles-virus containing vaccine, 9 were inadequately immunized, and an additional 6 infants had not been immunized because of age.
Conclusions. Measles importations continue in the United States. Travelers should be aware of the importance of assuring up-to-date immunizations, especially when visiting countries experiencing a local measles outbreak. In addition, parents traveling with infants, and their physicians, should be aware of recommendations regarding the early administration of a dose of measles-containing vaccine for infants at least 6 months old traveling internationally.
C1 [Edelson, Paul J.; Anderson, Janelle A.] US Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Natl Ctr Preparedness Detect & Control Infect Dis, Atlanta, GA USA.
[Anderson, Janelle A.] Council State & Territorial Epidemiologists CSTE, Atlanta, GA USA.
RP Edelson, PJ (reprint author), John F Kennedy Int Airport, CDC, New York Quarantine Stn, Terminal 4,Room 219-016, Jamaica, NY 11430 USA.
EM dou9@cdc.gov
NR 12
TC 5
Z9 5
U1 1
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1195-1982
J9 J TRAVEL MED
JI J. Travel Med.
PD MAY-JUN
PY 2011
VL 18
IS 3
BP 178
EP 182
DI 10.1111/j.1708-8305.2011.00502.x
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 759EI
UT WOS:000290223100006
PM 21539657
ER
PT J
AU Sharangpani, R
Boulton, KE
Wells, E
Kim, C
AF Sharangpani, Ruta
Boulton, Kathryn E.
Wells, Eden
Kim, Curi
TI Attitudes and Behaviors of International Air Travelers Toward Pandemic
Influenza
SO JOURNAL OF TRAVEL MEDICINE
LA English
DT Article
ID CHINESE GENERAL-POPULATION; A H1N1 VIRUS; AVIAN INFLUENZA; HONG-KONG;
INFECTIOUS-DISEASES; RISK BEHAVIORS; MAINLAND CHINA; OUTBREAK;
PERCEPTIONS; KNOWLEDGE
AB Methods. Prior to the 2009 H1N1 influenza pandemic, we surveyed a convenience sample of 404 departing international travelers at Detroit Metropolitan Wayne County Airport. Presented with a hypothetical pandemic influenza scenario occurring overseas, the participants predicted their anticipated protective behaviors while abroad and recorded their attitudes toward potential screening measures at US ports of entry (POE). The survey also qualitatively explored factors that would influence compliance with health entry screening at POE.
Results. Those who perceived pandemic influenza to be serious were more likely to state that they would be comfortable with screening (p = 0.006), and if they had influenza-like illness (ILI) overseas, would be more willing to see a physician and delay return travel (p = 0.006 and 0.002, respectively). Other demographic variables, including age and race, were associated with protective behaviors in response to ILI. Travelers also identified diverse information requirements which would influence their behavior in response to entry screening, including characteristics of the pandemic, severity of illness, and screening operations.
Conclusions. Demographic characteristics and perceived severity of illness are important factors that may influence the protective behaviors of travelers overseas. Our results indicate that educational material and advice directed to international travelers could be differentially tailored to traveler subpopulations.
C1 [Sharangpani, Ruta; Wells, Eden] Michigan Dept Community Hlth, Bur Epidemiol, Lansing, MI 48913 USA.
[Sharangpani, Ruta; Wells, Eden] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
[Boulton, Kathryn E.] Univ Michigan, Sch Publ Hlth, Dept Hlth Behav & Hlth Educ, Ann Arbor, MI 48109 USA.
[Boulton, Kathryn E.; Kim, Curi] Detroit Quarantine Stn, Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Detroit, MI USA.
RP Sharangpani, R (reprint author), Michigan Dept Community Hlth, Bur Epidemiol, Capitol View Bldg,201 Townsend St,5th Floor, Lansing, MI 48913 USA.
EM sharangpanir@michigan.gov
NR 37
TC 3
Z9 3
U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1195-1982
J9 J TRAVEL MED
JI J. Travel Med.
PD MAY-JUN
PY 2011
VL 18
IS 3
BP 203
EP 208
DI 10.1111/j.1708-8305.2011.00500.x
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 759EI
UT WOS:000290223100010
PM 21539661
ER
PT J
AU Stoll, BJ
Hansen, NI
Sanchez, PJ
Faix, RG
Poindexter, BB
Van Meurs, KP
Bizzarro, MJ
Goldberg, RN
Frantz, ID
Hale, EC
Shankaran, S
Kennedy, K
Carlo, WA
Watterberg, KL
Bell, EF
Walsh, MC
Schibler, K
Laptook, AR
Shane, AL
Schrag, SJ
Das, A
Higgins, RD
AF Stoll, Barbara J.
Hansen, Nellie I.
Sanchez, Pablo J.
Faix, Roger G.
Poindexter, Brenda B.
Van Meurs, Krisa P.
Bizzarro, Matthew J.
Goldberg, Ronald N.
Frantz, Ivan D., III
Hale, Ellen C.
Shankaran, Seetha
Kennedy, Kathleen
Carlo, Waldemar A.
Watterberg, Kristi L.
Bell, Edward F.
Walsh, Michele C.
Schibler, Kurt
Laptook, Abbot R.
Shane, Andi L.
Schrag, Stephanie J.
Das, Abhik
Higgins, Rosemary D.
CA Eunice Kennedy Shriver Natl Inst C
TI Early Onset Neonatal Sepsis: The Burden of Group B Streptococcal and E.
coli Disease Continues
SO PEDIATRICS
LA English
DT Article
DE neonatal sepsis; group B streptococcal disease; Escherichia coli
infection
ID INTRAPARTUM ANTIBIOTIC-PROPHYLAXIS; BIRTH-WEIGHT INFANTS;
INTENSIVE-CARE-UNIT; ESCHERICHIA-COLI; PRETERM INFANTS; INFECTIONS; ERA;
MENINGITIS; RESISTANCE; PATTERNS
AB BACKGROUND: Guidelines for prevention of group B streptococcal (GBS) infection have successfully reduced early onset (EO) GBS disease. Study results suggest that Escherichia coli is an important EO pathogen.
OBJECTIVE: To determine EO infection rates, pathogens, morbidity, and mortality in a national network of neonatal centers.
METHODS: Infants with EO infection were identified by prospective surveillance at Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Network centers. Infection was defined by positive culture results for blood and cerebrospinal fluid obtained from infants aged <= 72 hours plus treatment with antibiotic therapy for >= 5 days. Mother and infant characteristics, treatments, and outcomes were studied. Numbers of cases and total live births (LBs) were used to calculate incidence.
RESULTS: Among 396 586 LBs (2006-2009), 389 infants developed EO infection (0.98 cases per 1000 LBs). Infection rates increased with decreasing birth weight. GBS (43%, 0.41 per 1000 LBs) and E coli (29%, 0.28 per 1000 LBs) were most frequently isolated. Most infants with GBS were term (73%); 81% with E coli were preterm. Mothers of 67% of infected term and 58% of infected preterm infants were screened for GBS, and results were positive for 25% of those mothers. Only 76% of mothers with GBS colonization received intrapartum chemoprophylaxis. Although 77% of infected infants required intensive care, 20% of term infants were treated in the normal newborn nursery. Sixteen percent of infected infants died, most commonly with E coli infection (33%).
CONCLUSION: In the era of intrapartum chemoprophylaxis to reduce GBS, rates of EO infection have declined but reflect a continued burden of disease. GBS remains the most frequent pathogen in term infants, and E coli the most significant pathogen in preterm infants. Missed opportunities for GBS prevention continue. Prevention of E coli sepsis, especially among preterm infants, remains a challenge. Pediatrics 2011;127:817-826
C1 [Stoll, Barbara J.; Hale, Ellen C.; Shane, Andi L.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30322 USA.
[Stoll, Barbara J.; Hale, Ellen C.; Shane, Andi L.] Childrens Healthcare Atlanta, Atlanta, GA USA.
[Hansen, Nellie I.] RTI Int, Stat & Epidemiol Unit, Res Triangle Pk, NC USA.
[Sanchez, Pablo J.] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA.
[Faix, Roger G.] Univ Utah, Sch Med, Dept Pediat, Div Neonatol, Salt Lake City, UT USA.
[Poindexter, Brenda B.] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN USA.
[Van Meurs, Krisa P.] Stanford Univ, Med Ctr, Div Neonatol, Palo Alto, CA 94304 USA.
[Bizzarro, Matthew J.] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06510 USA.
[Goldberg, Ronald N.] Duke Univ, Dept Pediat, Durham, NC 27706 USA.
[Frantz, Ivan D., III] Floating Hosp Children, Tufts Med Ctr, Dept Pediat, Boston, MA USA.
[Shankaran, Seetha] Wayne State Univ, Dept Pediat, Detroit, MI 48202 USA.
[Kennedy, Kathleen] Univ Texas Med Sch Houston, Dept Pediat, Houston, TX USA.
[Carlo, Waldemar A.] Univ Alabama Birmingham, Div Neonatol, Birmingham, AL USA.
[Watterberg, Kristi L.] Univ New Mexico, Dept Pediat, Hlth Sci Ctr, Albuquerque, NM 87131 USA.
[Bell, Edward F.] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA.
[Walsh, Michele C.] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA.
[Schibler, Kurt] Univ Cincinnati, Dept Pediat, Cincinnati, OH 45221 USA.
[Laptook, Abbot R.] Brown Univ, Women & Infants Hosp, Dept Pediat, Providence, RI 02908 USA.
[Schrag, Stephanie J.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Das, Abhik] RTI Int, Stat & Epidemiol Unit, Rockville, MD USA.
[Higgins, Rosemary D.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA.
RP Stoll, BJ (reprint author), Emory Univ, Sch Med, Dept Pediat, 2015 Uppergate Dr, Atlanta, GA 30322 USA.
EM barbara_stoll@oz.ped.emory.edu
FU National Institutes of Health (NIH); National Institutes of Health,
National Center for Research Resources [UL1 RR025008]; National
Institutes of Health; NICHD; Centers for Disease Control and Prevention
FX Funded by the National Institutes of Health (NIH).; This study was
supported in part by PHS grant UL1 RR025008 from the Clinical and
Translational Science Award program, National Institutes of Health,
National Center for Research Resources. The National Institutes of
Health, the NICHD, and the Centers for Disease Control and Prevention
provided grant support for the Neonatal Research Network's Early Onset
Sepsis Study. Data collected at participating sites of the NICHD NRN
were transmitted to RTI International, the data coordinating center
(DCC) for the network, which stored, managed, and analyzed the data for
this study. On behalf of the NRN, Dr Abhik Das (DCC Principal
Investigator), and Ms Nellie Hansen (DCC Statistician) had full access
to all the data in the study and take responsibility for the integrity
of the data and accuracy of the data analysis.
NR 25
TC 248
Z9 261
U1 4
U2 30
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
IS 5
BP 817
EP 826
DI 10.1542/peds.2010-2217
PG 10
WC Pediatrics
SC Pediatrics
GA 757OO
UT WOS:000290097800040
PM 21518717
ER
PT J
AU Paulson, JA
Binns, HJ
Brumberg, HL
Forman, JA
Karr, CJ
Osterhoudt, KC
Sandel, MT
Seltzer, JM
Wright, RO
Mortensen, M
Savage, S
Rogan, WJ
Pellegrini, C
Spire, P
AF Paulson, Jerome A.
Binns, Helen J.
Brumberg, Heather L.
Forman, Joel A.
Karr, Catherine J.
Osterhoudt, Kevin C.
Sandel, Megan T.
Seltzer, James M.
Wright, Robert O.
Mortensen, Mary
Savage, Sharon
Rogan, Walter J.
Pellegrini, Cindy
Spire, Paul
TI Policy Statement-Chemical-Management Policy: Prioritizing Children's
Health
SO PEDIATRICS
LA English
DT Article
DE environmental health
ID POLYBROMINATED DIPHENYL ETHERS; BREAST-MILK; PBDES
AB The American Academy of Pediatrics recommends that chemical-management policy in the United States be revised to protect children and pregnant women and to better protect other populations. The Toxic Substance Control Act (TSCA) was passed in 1976. It is widely recognized to have been ineffective in protecting children, pregnant women, and the general population from hazardous chemicals in the marketplace. It does not take into account the special vulnerabilities of children in attempting to protect the population from chemical hazards. Its processes are so cumbersome that in its more than 30 years of existence, the TSCA has been used to regulate only 5 chemicals or chemical classes of the tens of thousands of chemicals that are in commerce. Under the TSCA, chemical companies have no responsibility to perform premarket testing or postmarket follow-up of the products that they produce; in fact, the TSCA contains disincentives for the companies to produce such data. Voluntary programs have been inadequate in resolving problems. Therefore, chemical-management policy needs to be rewritten in the United States. Manufacturers must be responsible for developing information about chemicals before marketing. The US Environmental Protection Agency must have the authority to demand additional safety data about a chemical and to limit or stop the marketing of a chemical when there is a high degree of suspicion that the chemical might be harmful to children, pregnant women, or other populations. Pediatrics 2011; 127: 983-990
C1 [Mortensen, Mary] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Savage, Sharon] NCI, Bethesda, MD 20892 USA.
NR 41
TC 20
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U1 0
U2 8
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
IS 5
BP 983
EP 990
DI 10.1542/peds.2011-0523
PG 8
WC Pediatrics
SC Pediatrics
GA 757OO
UT WOS:000290097800060
ER
PT J
AU Hersh, JH
Saul, RA
Saal, HM
Braddock, SR
Enns, GM
Gruen, JR
Perrin, JM
Tarini, BA
Hanson, JW
Lloyd-Puryear, MA
Musci, TJ
Rasmussen, SA
Spire, P
AF Hersh, Joseph H.
Saul, Robert A.
Saal, Howard M.
Braddock, Stephen R.
Enns, Gregory M.
Gruen, Jeffrey R.
Perrin, James M.
Tarini, Beth Anne
Hanson, James W.
Lloyd-Puryear, Michele Ann
Musci, Thomas J.
Rasmussen, Sonja Ann
Spire, Paul
TI Clinical Report-Health Supervision for Children With Fragile X Syndrome
SO PEDIATRICS
LA English
DT Article
DE fragile X syndrome; FMR1-related conditions; mental retardation; health
guidelines
ID PREMATURE OVARIAN FAILURE; TREMOR/ATAXIA SYNDROME; FMR1 PREMUTATION;
AUTISM; EXPERIENCES; POPULATION; DISORDERS; ATTITUDES; FXTAS
AB Fragile X syndrome (an FMR1-related disorder) is the most commonly inherited form of mental retardation. Early physical recognition is difficult, so boys with developmental delay should be strongly considered for molecular testing. The characteristic adult phenotype usually does not develop until the second decade of life. Girls can also be affected with developmental delay. Because multiple family members can be affected with mental retardation and other conditions (premature ovarian failure and tremor/ataxia), family history information is of critical importance for the diagnosis and management of affected patients and their families. This report summarizes issues for fragile X syndrome regarding clinical diagnosis, laboratory diagnosis, genetic counseling, related health problems, behavior management, and age-related health supervision guidelines. The diagnosis of fragile X syndrome not only involves the affected children but also potentially has significant health consequences for multiple generations in each family. Pediatrics 2011; 127: 994-1006
C1 [Lloyd-Puryear, Michele Ann] US Hlth Resources & Serv Adm, Rockville, MD 20857 USA.
[Rasmussen, Sonja Ann] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 35
TC 17
Z9 18
U1 0
U2 7
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
IS 5
BP 994
EP 1006
DI 10.1542/peds.2010-3500
PG 13
WC Pediatrics
SC Pediatrics
GA 757OO
UT WOS:000290097800062
PM 21518720
ER
PT J
AU Gaur, AH
Freimanis-Hance, L
Dominguez, K
Mitchell, C
Menezes, J
Mussi-Pinhata, MM
Peixoto, MF
Alarcon, J
Coelho, DF
Read, JS
AF Gaur, Aditya H.
Freimanis-Hance, Laura
Dominguez, Kenneth
Mitchell, Charles
Menezes, Jacqueline
Mussi-Pinhata, Marisa M.
Peixoto, Mario F.
Alarcon, Jorge
Coelho, Debora F.
Read, Jennifer S.
TI Knowledge and Practice of Prechewing/Prewarming Food by HIV-Infected
Women
SO PEDIATRICS
LA English
DT Article
DE HIV; prechewing; prewarming; premastication; child
ID INFANT; PREMASTICATION
AB OBJECTIVE: HIV transmission has been associated with offering a child food prechewed by an HIV-infected caregiver. We assessed awareness of prechewing and oral prewarming of food by an adult before offering it to a child among HIV-infected pregnant women and clinical investigators in 3 Latin American countries.
METHODS: HIV-infected pregnant women at 12 sites (Eunice Kennedy Shriver National Institute of Child Health and Human Development International Site Development Initiative Perinatal Longitudinal Study in Latin American Countries, a prospective cohort trial) in Argentina, Brazil, and Peru were administered a screening survey about prechewing/prewarming of infant foods and cautioned against these feeding practices. Survey responses were analyzed, overall, and stratified according to country.
RESULTS: Of the 401 HIV-infected pregnant women interviewed, 34% had heard about prechewing (50% from Argentina, 32% from Brazil, and 36% from Peru), 23% knew someone who prechewed food for infants, and 4% had prechewed food in the past. Seventeen percent had heard about oral prewarming of food, 13% knew someone who prewarmed food for infants, and 3% had prewarmed food for an infant in the past. Women who reported knowing someone who prechewed were more likely to also know someone who prewarmed food (P < .0001). Few site investigators anticipated that their patients would be aware of these practices.
CONCLUSIONS: Prechewing food, a potential risk factor for HIV transmission, and orally prewarming food, which has not been associated with HIV transmission but might expose a child to blood from an HIV-infected adult, are not uncommon practices in Latin America. Both practices should be further investigated. Site investigator responses underscore that health care providers could be missing information about cultural practices that patients may not report unless specifically asked. Pediatrics 2011;127:e1206-e1211
C1 [Gaur, Aditya H.] St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA.
[Freimanis-Hance, Laura] Westat Corp, Rockville, MD USA.
[Dominguez, Kenneth] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA.
[Mitchell, Charles] Univ Miami, Miller Sch Med, Dept Pediat, Miami, FL 33136 USA.
[Menezes, Jacqueline] Hosp Servidores Estado, Policlin Santa Clara, Unidade Pesquisa Materno Infantil, Rio De Janeiro, Brazil.
[Mussi-Pinhata, Marisa M.] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, Brazil.
[Peixoto, Mario F.] Hosp Femina, Dept Infect Dis, Porto Alegre, RS, Brazil.
[Alarcon, Jorge] Univ Nacl Mayor San Marcos, Inst Med Trop Daniel Alcides Carrion, Secc Epidemiol, Lima 14, Peru.
[Coelho, Debora F.] Irmandade Santa Casa de Misericordia, Serv Doencas Infecciosas & Parasitarias, Porto Alegre, RS, Brazil.
[Read, Jennifer S.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Adolescent & Maternal AIDS Branch, Ctr Res Mothers & Children, NIH, Bethesda, MD 20892 USA.
RP Gaur, AH (reprint author), St Jude Childrens Hosp, Dept Infect Dis MS 600, 262 Danny Thomas Pl, Memphis, TN 38105 USA.
EM aditya.gaur@stjude.org
RI Mussi-Pinhata, Marisa/G-6568-2012;
OI Alarcon, Jorge/0000-0002-0800-2380
FU National Institutes of Health (NIH); NICHD [N01-HD-3-3345,
HHSN267200800001C, N01-HD-8-0001]
FX Funded by the National Institutes of Health (NIH).; Principal
investigators, co-principal investigators, study coordinators,
coordinating center representatives, and NICHD staff include: Argentina:
Buenos Aires: Marcelo H. Losso, Irene Foradori, Claudia Checa, Silvina
Ivalo (Hospital General de Agudos Jose Maria Ramos Mejia); Brazil: Belo
Horizonte: Jorge Pinto, Victor Melo, Fabiana Kakehasi (Universidade
Federal de Minas Gerais); Caxias do Sul: Ricardo da Silva de Souza,
Nicole Golin, S~lvia Mariani Costamilan (Universidade de Caxias do
Sul/Servico Municipal de Infectologia); Nova Iguacu: Jose Pilotto,
Beatriz Grinsztejn, Valdilea Veloso, Gisely Falco (Hospital Geral Nova
de Iguacu - HIV Family Care Clinic); Porto Alegre: Ricardo da Silva de
Souza, Breno Riegel Santos, Rita de Cassia Alves Lira (Universidade de
Caxias do Sul/Hospital Conceicao); Ricardo da Silva de Souza, Mario
Ferreira Peixoto, Elizabete Teles (Universidade de Caxias do
Sul/Hospital Famina); Regis Kreitchmann, Luis Carlos Ribeiro, Fabrizio
Motta, Debora Fernandes Coelho (Irmandade da Santa Casa de Misericordia
de Porto Alegre); Ribeirao Preto: Marisa M. Mussi-Pinhata, Geraldo
Duarte, Adriana A. Tiraboschi Barbaro, Conrado Milani Coutinho, Anderson
Sanches de Melo (Hospital das Clinicas da Faculdade de Medicina de
Ribeirao Preto da Universidade de Sao Paulo); Rio de Janeiro: Ricardo
Hugo S. Oliveira, Elizabeth S. Machado, Maria C. Chermont Sapia
(Instituto de Puericultura e Pediatria Martagao Gesteira); Esau Custodio
Joao, Leon Claude Sidi, Ezequias Martins, Plinio Tostes Berardo
(Hospital dos Servidores do Estado); Sao Paulo: Regina Celia de Menezes
Succi, Prescilla Chow (Universidade Federal de Sao Paulo); Peru: Lima:
Jorge Alarcon Villaverde (Instituto de Medicina Tropical "Daniel Alcides
Carrion"-Seccion de Epidemiologia, UNMSM), Carlos Velasquez Vasquez
(Instituto Nacional Materno Perinatal), Cesar Gutierrez Villafuerte
(Instituto de Medicina Tropical "Daniel Alcides Carrion"-Seccion de
Epidemiologia, UNMSM); Data Management and Statistical Center: Yolanda
Bertucci, Laura Freimanis Hance, Rene Gonin, D. Robert Harris, Roslyn
Hennessey, James Korelitz, Margot Krauss, Sharon Sothern de Sanchez,
Sonia K. Stoszek (Westat, Rockville, MD, USA); NICHD: Rohan Hazra, Lynne
Mofenson, Jennifer S. Read, Heather Watts, Carol Worrell (Eunice Kennedy
Shriver National Institute of Child Health and Human Development,
Bethesda, Maryland, USA). Supported by NICHD Contract # N01-HD-3-3345
(2002-2007) and by NICHD Contract # HHSN267200800001C (NICHD Control #:
N01-HD-8-0001) (2007-2012).
NR 18
TC 4
Z9 4
U1 0
U2 3
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
IS 5
BP E1206
EP E1211
DI 10.1542/peds.2010-1902
PG 6
WC Pediatrics
SC Pediatrics
GA 757OO
UT WOS:000290097800014
PM 21482608
ER
PT J
AU Klein, NP
Aukes, L
Lee, J
Fireman, B
Shapira, SK
Slade, B
Baxter, R
Summar, M
AF Klein, Nicola P.
Aukes, Laurie
Lee, Janelle
Fireman, Bruce
Shapira, Stuart K.
Slade, Barbara
Baxter, Roger
Summar, Marshall
TI Evaluation of Immunization Rates and Safety Among Children With Inborn
Errors of Metabolism
SO PEDIATRICS
LA English
DT Article
DE inborn errors of metabolism; vaccine safety; immunization rates
ID DISORDERS; VACCINATION
AB BACKGROUND: Children with inherited metabolic disorders are a potential high-risk group for vaccine-preventable diseases, yet information regarding immunization rates and vaccine safety within this population is limited.
METHODS: Using Northern California Kaiser Permanente's electronic medical record, we identified children with inborn errors of metabolism from 1990 to 2007. We assessed immunization rates among infants with inborn errors of metabolism born at Northern California Kaiser Permanente matched to healthy infants (1 to 20), comparing both vaccines received by 2 years of age and age at vaccination. We assessed postvaccination adverse events among children up to 18 years old with inborn errors of metabolism, separately comparing emergency-department visits and hospitalizations during postvaccine days 0 to 30 (primary) and days 0 to 14 (secondary).
RESULTS: Comparing infants with inborn errors of metabolism (n = 77) versus matched control subjects (n = 1540), similar proportions were up to date for vaccines at 2 years of age, and there was no evidence of delay in receipt of recommended vaccines during the first year. Vaccination of children with inborn errors of metabolism (n = 271) was not associated with any significant increase in emergency-department visits or hospitalizations during the 30 days after vaccination. Secondary analyses suggested that there may be increased rates of hospitalizations 2 weeks after vaccination for the sickest 1- to 4-year-old children.
CONCLUSIONS: Children with inborn errors of metabolism at Northern California Kaiser Permanente received vaccines on the same immunization schedule as healthy infants. Immunization was not associated with increased risk for serious adverse events during the month after vaccination, providing overall reassurance that routine vaccination of children with inborn errors of metabolism does not result in adverse effects. Pediatrics 2011;127:e1139-e1146
C1 [Klein, Nicola P.; Aukes, Laurie; Lee, Janelle; Fireman, Bruce; Baxter, Roger] Kaiser Permanente Vaccine Study Ctr, Oakland, CA 94612 USA.
[Shapira, Stuart K.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Slade, Barbara] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA USA.
[Summar, Marshall] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA.
RP Klein, NP (reprint author), Kaiser Permanente Vaccine Study Ctr, 1 Kaiser Plaza,16th Floor, Oakland, CA 94612 USA.
EM nicola.klein@kp.org
FU Merck and Co; Novartis; GlaxoSmithKline; Pfizer; Sanofi-Pasteur;
Clinical Immunization Safety Assessment Network; Centers for Disease
Control and Prevention [200-2002-00732]
FX Nicola P. Klein and Roger Baxter have received research support from
Merck and Co, Novartis, GlaxoSmithKline, Pfizer and Sanofi-Pasteur.;
This study was funded by the Clinical Immunization Safety Assessment
Network through a subcontract with America's Health Insurance Plans
under contract 200-2002-00732 from the Centers for Disease Control and
Prevention.
NR 14
TC 11
Z9 11
U1 0
U2 1
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2011
VL 127
IS 5
BP E1139
EP E1146
DI 10.1542/peds.2010-3706
PG 8
WC Pediatrics
SC Pediatrics
GA 757OO
UT WOS:000290097800005
PM 21482602
ER
PT J
AU Wimonsate, W
Naorat, S
Varangrat, A
Phanuphak, P
Kanggarnrua, K
McNicholl, J
Akarasewi, P
van Griensven, F
AF Wimonsate, Wipas
Naorat, Sathapana
Varangrat, Anchalee
Phanuphak, Praphan
Kanggarnrua, Kamolset
McNicholl, Janet
Akarasewi, Passakorn
van Griensven, Frits
TI Factors Associated with HIV Testing History and Returning for HIV Test
Results Among Men Who have Sex with Men in Thailand
SO AIDS AND BEHAVIOR
LA English
DT Article
DE Men who have sex with men; HIV/AIDS; HIV testing; Thailand
ID RISK; FAILURE
AB We evaluated factors associated with HIV testing history and returning for HIV test results among 2,049 Thai men who have sex with men. Of men, 50.3% reported prior HIV testing and 24.9% returned for HIV test results. Factors associated with prior HIV testing were male sex work, older age, employed, living away from the family, insertive anal sex role, history of drug use and having heard of effective HIV/AIDS treatment. Factors associated with returning for HIV test results were male sex work, older age, lack of a family confidant, history of sexually transmitted infections, and testing HIV negative in this study.
C1 [Wimonsate, Wipas; Naorat, Sathapana; Varangrat, Anchalee; McNicholl, Janet; van Griensven, Frits] US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Minist Publ Hlth, Nonthaburi 11000, Thailand.
[Phanuphak, Praphan] Thai Red Cross Soc, Bangkok, Thailand.
[Kanggarnrua, Kamolset] Rainbow Sky Assoc Thailand, Bangkok, Thailand.
[McNicholl, Janet; van Griensven, Frits] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA.
RP Wimonsate, W (reprint author), US Ctr Dis Control & Prevent Collaborat, Thailand Minist Publ Hlth, Minist Publ Hlth, 4th Floor DDC7, Nonthaburi 11000, Thailand.
EM wipasw@th.cdc.gov
RI van Griensven, Frits/G-4719-2013
OI van Griensven, Frits/0000-0002-0971-2843
NR 12
TC 10
Z9 11
U1 1
U2 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-7165
J9 AIDS BEHAV
JI AIDS behav.
PD MAY
PY 2011
VL 15
IS 4
BP 693
EP 701
DI 10.1007/s10461-010-9755-3
PG 9
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 754YS
UT WOS:000289894400002
PM 20623251
ER
PT J
AU Stein, R
Green, K
Bell, K
Toledo, CA
Uhl, G
Moore, A
Shelley, GA
Hardnett, FP
AF Stein, Renee
Green, Kathleen
Bell, Kelly
Toledo, Carlos A.
Uhl, Gary
Moore, Andrea
Shelley, Gene A.
Hardnett, Felicia P.
TI Provision of HIV Counseling and Testing Services at Five Community-Based
Organizations Among Young Men of Color Who Have Sex with Men
SO AIDS AND BEHAVIOR
LA English
DT Article
DE HIV testing; Men who have sex with men; MSM; Community-based
organizations; CBO
ID UNITED-STATES; PREVENTION; BEHAVIORS; RISK; IMPLEMENTATION; INFECTION;
SETTINGS; PROGRAMS; HIV/AIDS; OUTREACH
AB In the context of monitoring and improving CDC-funded HIV prevention programs, we describe HIV tests and infections, provision of results, previous HIV tests, and risk behaviors for young (aged 13-29) men of color who have sex with men who received HIV tests at five community-based organizations. Of 1,723 tests provided, 2.1% were positive and 75.7% of positives were previously unaware of their infection. The highest positivity rate was among men aged 25-29 (4.7%). Thirty-four percent of tests were provided to men who were tested for the first time. Over half the tests (53.2%) were provided to men who reported sex with a person of unknown HIV status, and 34% to men who reported sex with an anonymous partner. Continued and more focused prevention efforts are needed to reach and test young men of color who have sex with men and to identify previously undiagnosed HIV infections among this target population.
C1 [Stein, Renee; Green, Kathleen; Toledo, Carlos A.; Uhl, Gary; Shelley, Gene A.; Hardnett, Felicia P.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
[Bell, Kelly] Emergent Technol, Louisville, KY USA.
[Moore, Andrea] MANILA Consulting Grp Inc, Mclean, VA USA.
RP Stein, R (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mail Stop E-59, Atlanta, GA 30333 USA.
EM rstein1@cdc.gov
NR 27
TC 3
Z9 3
U1 0
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-7165
J9 AIDS BEHAV
JI AIDS behav.
PD MAY
PY 2011
VL 15
IS 4
BP 743
EP 750
DI 10.1007/s10461-010-9821-x
PG 8
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 754YS
UT WOS:000289894400008
PM 20945158
ER
PT J
AU MacKellar, DA
Hou, SI
Whalen, CC
Samuelsen, K
Valleroy, LA
Secura, GM
Behel, S
Bingham, T
Celentano, DD
Koblin, BA
LaLota, M
Shehan, D
Thiede, H
Torian, LV
AF MacKellar, Duncan A.
Hou, Su-I
Whalen, Christopher C.
Samuelsen, Karen
Valleroy, Linda A.
Secura, Gina M.
Behel, Stephanie
Bingham, Trista
Celentano, David D.
Koblin, Beryl A.
LaLota, Marlene
Shehan, Douglas
Thiede, Hanne
Torian, Lucia V.
TI A Plausible Causal Model of HAART-Efficacy Beliefs, HIV/AIDS
Complacency, and HIV-Acquisition Risk Behavior Among Young Men Who Have
Sex with Men
SO AIDS AND BEHAVIOR
LA English
DT Article
DE HIV/AIDS complacency; HAART optimism; HIV treatment beliefs; Structural
equation modeling; Men who have sex with men
ID ACTIVE ANTIRETROVIRAL THERAPY; LONDON GAY MEN; BISEXUAL MEN; COMBINATION
THERAPIES; UNITED-STATES; ANTICIPATED REGRET; TREATMENT OPTIMISM;
PLANNED BEHAVIOR; HOMOSEXUAL-MEN; FEAR APPEALS
AB Despite considerable research, the causal relationship remains unclear between HIV/AIDS complacency, measured as reduced HIV/AIDS concern because of highly active antiretroviral therapy (HAART), and HIV risk behavior. Understanding the directionality and underpinnings of this relationship is critical for programs that target HIV/AIDS complacency as a means to reduce HIV incidence among men who have sex with men (MSM). This report uses structural equation modeling to evaluate a theory-based, HIV/AIDS complacency model on 1,593 MSM who participated in a venue-based, cross-sectional survey in six U.S. cities, 1998-2000. Demonstrating adequate fit and stability across geographic samples, the model explained 15.0% of the variance in HIV-acquisition behavior among young MSM. Analyses that evaluated alternative models and models stratified by perceived risk for HIV infection suggest that HIV/AIDS complacency increases acquisition behavior by mediating the effects of two underlying HAART-efficacy beliefs. New research is needed to assess model effects on current acquisition risk behavior, and thus help inform prevention programs designed to reduce HIV/AIDS complacency and HIV incidence among young MSM.
C1 [MacKellar, Duncan A.; Valleroy, Linda A.; Secura, Gina M.; Behel, Stephanie] Ctr Dis Control & Prevent, Div HIV AIDS Prevent Surveillance & Epidemiol, Natl Ctr HIV STD & TB Prevent, Atlanta, GA 30333 USA.
[Hou, Su-I; Whalen, Christopher C.] Univ Georgia, Coll Publ Hlth, Athens, GA 30602 USA.
[Samuelsen, Karen] Univ Georgia, Dept Educ Psychol & Instruct Technol, Athens, GA 30602 USA.
[Bingham, Trista] Los Angeles Cty Dept Hlth Serv, Los Angeles, CA USA.
[Celentano, David D.] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Baltimore, MD USA.
[Koblin, Beryl A.] New York Blood Ctr, New York, NY 10021 USA.
[LaLota, Marlene] Florida Dept Hlth, Tallahassee, FL USA.
[Shehan, Douglas] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
[Thiede, Hanne] Publ Hlth Seattle & King Cty, Seattle, WA USA.
[Torian, Lucia V.] New York City Dept Hlth, New York, NY 10013 USA.
RP MacKellar, DA (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent Surveillance & Epidemiol, Natl Ctr HIV STD & TB Prevent, 1600 Clifton Rd NE,MS E-46, Atlanta, GA 30333 USA.
EM dym4@cdc.gov
OI Hou, Su-I/0000-0002-4519-0974
FU NCRR NIH HHS [M01 RR000052]
NR 58
TC 8
Z9 8
U1 3
U2 11
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-7165
J9 AIDS BEHAV
JI AIDS Behav.
PD MAY
PY 2011
VL 15
IS 4
BP 788
EP 804
DI 10.1007/s10461-010-9813-x
PG 17
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 754YS
UT WOS:000289894400013
PM 20862605
ER
PT J
AU Blaney, DD
Daly, ER
Kirkland, KB
Tongren, JE
Kelso, PT
Talbot, EA
AF Blaney, David D.
Daly, Elizabeth R.
Kirkland, Kathryn B.
Tongren, Jon Eric
Kelso, Patsy Tassler
Talbot, Elizabeth A.
TI Use of alcohol-based hand sanitizers as a risk factor for norovirus
outbreaks in long-term care facilities in northern New England: December
2006 to March 2007
SO AMERICAN JOURNAL OF INFECTION CONTROL
LA English
DT Article
DE Norovirus; outbreak; long-term care facility; infection control;
alcohol-based hand sanitizer; hand hygiene
ID ACUTE NONBACTERIAL GASTROENTERITIS; NORWALK-LIKE VIRUSES; FELINE
CALICIVIRUS; HOSPITAL OUTBREAK; NURSING-HOME; VIRAL GASTROENTERITIS;
UNITED-STATES; INACTIVATION; TRANSMISSION; SURROGATES
AB Background: During December 2006 to March 2007, a substantial increase in norovirus illnesses was noted in northern New England. We sought to identify institutional risk factors for norovirus outbreaks in northern New England long-term care facilities (LTCFs).
Methods: State health departments in Maine, New Hampshire, and Vermont distributed surveys to infection preventionists at all LTCFs in their respective states. We collected information regarding facility attributes, routine staff use of alcohol-based hand sanitizer (ABHS) versus soap and water, facility cleaning practices, and occurrence of any acute gastroenteritis outbreaks during December 2006 to March 2007. Norovirus confirmation was conducted in public health laboratories. Data were analyzed with univariate and logistic regression methods.
Results: Of 160 facilities, 91 (60%) provided survey responses, with 61 facilities reporting 73 outbreaks; 29 were confirmed norovirus. Facilities reporting that staff were equally or more likely to use ABHS than soap and water for routine hand hygiene had higher odds of an outbreak than facilities with staff less likely to use ABHS (adjusted odds ratio, 6.06; 95% confidence interval: 1.44-33.99).
Conclusion: This study suggests that preferential use of ABHS over soap and water for routine hand hygiene might be associated with increased risk of norovirus outbreaks in LTCFs.
C1 [Blaney, David D.; Tongren, Jon Eric] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA.
[Blaney, David D.; Daly, Elizabeth R.; Talbot, Elizabeth A.] New Hampshire Dept Hlth & Human Serv, Concord, NH 03301 USA.
[Kirkland, Kathryn B.; Talbot, Elizabeth A.] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Hanover, NH 03756 USA.
[Tongren, Jon Eric] Maine Dept Hlth & Human Serv, Augusta, GA USA.
[Kelso, Patsy Tassler] Vermont Dept Hlth, Burlington, VT 05402 USA.
RP Blaney, DD (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, 1600 Clifton Rd NE,MS C-09, Atlanta, GA 30333 USA.
EM dblaney@cdc.gov
NR 27
TC 17
Z9 18
U1 1
U2 18
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-6553
J9 AM J INFECT CONTROL
JI Am. J. Infect. Control
PD MAY
PY 2011
VL 39
IS 4
BP 296
EP 301
DI 10.1016/j.ajic.2010.10.010
PG 6
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 756NK
UT WOS:000290019000008
PM 21411187
ER
PT J
AU Fujishiro, K
Gee, GC
de Castro, AB
AF Fujishiro, Kaori
Gee, Gilbert C.
de Castro, A. B.
TI Associations of Workplace Aggression With Work-Related Well-Being Among
Nurses in the Philippines
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID SELF-RATED HEALTH; MINNESOTA NURSES; HOSPITAL STAFF; MORTALITY;
VIOLENCE; ASSAULT; METAANALYSIS; PERSPECTIVE; PREVALENCE; COMMUNITY
AB Objectives. We examined whether workplace aggression was associated with self-rated health and work-related injury and illness among nurses in the Philippines.
Methods. Our data came from a cross-sectional survey of nurses (n=687) in the Philippines. We assessed the associations of self-reported physical assault and verbal abuse with self-rated health, work-related injury and illness, and missed workdays with Poisson regression. Control variables included demographic and work characteristics (e.g., hours worked, work setting, shift).
Results. Verbal abuse was associated with poor general health (prevalence ratio [PR]=1.94; 95% confidence interval [CI]=1.09, 3.45). Both physical assault and verbal abuse were associated with work-related injury (PR=1.48; 95% CI=1.00, 2.20; PR=1.72; 95% CI=1.34, 2.23, respectively) and work-related illness (PR=1.46; 95% CI=0.99, 2.15; PR=1.68; 95% CI=1.32, 2.14, respectively) after demographic and work characteristics were accounted for in the model. In addition, physical assault was associated with missed workdays (PR=1.56; 95% CI=1.02, 2.33).
Conclusions. Workplace aggression was associated with increased risks of poor general health and adverse work-related health outcomes among nurses in the Philippines. (Am J Public Health. 2011;101:861-867. doi:10.2105/AJPH.2009.188144)
C1 [Fujishiro, Kaori] NIOSH, DSHEFS, Cincinnati, OH 45226 USA.
[Gee, Gilbert C.] Univ Calif Los Angeles, Dept Community Hlth Sci, Los Angeles, CA USA.
[de Castro, A. B.] Univ Washington, Sch Nursing, Seattle, WA 98195 USA.
RP Fujishiro, K (reprint author), NIOSH, DSHEFS, 4676 Columbia Pkwy R-15, Cincinnati, OH 45226 USA.
EM kfujishiro@cdc.gov
FU University of Washington School of Nursing; National Center for Research
Resources (NCRR) [1 KL2RR025015-01]; National Institutes of Health (NIH)
and NIH Roadmap for Medical Research
FX This study was made possible by funds from the University of Washington
School of Nursing and the National Center for Research Resources (NCRR;
grant 1 KL2RR025015-01), a component of the National Institutes of
Health (NIH) and NIH Roadmap for Medical Research.
NR 32
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U1 0
U2 11
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD MAY
PY 2011
VL 101
IS 5
BP 861
EP 867
DI 10.2105/AJPH.2009.188144
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 753GT
UT WOS:000289761000026
PM 21088262
ER
PT J
AU van't Hoog, AH
Laserson, KF
Githui, WA
Meme, HK
Agaya, JA
Odeny, LO
Muchiri, BG
Marston, BJ
DeCock, KM
Borgdorff, MW
AF van't Hoog, Anna H.
Laserson, Kayla F.
Githui, Willie A.
Meme, Helen K.
Agaya, Janet A.
Odeny, Lazarus O.
Muchiri, Benson G.
Marston, Barbara J.
DeCock, Kevin M.
Borgdorff, Martien W.
TI High Prevalence of Pulmonary Tuberculosis and Inadequate Case Finding in
Rural Western Kenya
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article
DE prevalence; case finding; HIV infection; pulmonary tuberculosis;
epidemiology
ID SOUTH-AFRICA; INFECTIOUS TUBERCULOSIS; COMMUNITY LEADERS; HIV; BURDEN;
IMPACT; SURVEILLANCE; MORTALITY; INDICATOR; DIAGNOSIS
AB Rationale: Limited information exists on the prevalence of tuberculosis and adequacy of case finding in African populations with high rates of HIV.
Objectives: To estimate the prevalence of bacteriologically confirmed pulmonary tuberculosis (PTB) and the fraction attributable to HIV, and to evaluate case detection.
Methods: Residents aged 15 years and older, from 40 randomly sampled clusters, provided two sputum samples for microscopy; those with chest radiograph abnormalities or symptoms suggestive of PTB provided one additional sputum sample for culture.
Measurements and Main Results: PTB was defined by a culture positive for Mycobacterium tuberculosis or two positive smears. Persons with PTB were offered HIV testing and interviewed on care-seeking behavior. We estimated the population-attributable fraction of HIV on prevalent and notified PTB, the patient diagnostic rate, and case detection rate using provincial TB notification data. Among 20,566 participants, 123 had PTB. TB prevalence was 6.0/1,000 (95% confidence interval, 4.6-7.4) for all PTB and 2.5/1,000 (1.6-3.4) for smear-positive PTB. Of 101 prevalent TB cases tested, 52 (51%) were HIV infected, and 58 (64%) of 91 cases who were not on treatment and were interviewed had not sought care. Forty-eight percent of prevalent and 65% of notified PTB cases were attributable to HIV. For smear-positive and smear-negative PTB combined, the patient diagnostic rate was 1.4 cases detected per person-year among HIV-infected persons having PTB and 0.6 for those who were HIV uninfected, corresponding to case detection rates of 56 and 65%, respectively.
Conclusions: Undiagnosed PTB is common in this community. TB case finding needs improvement, for instance through intensified case finding with mobile smear microscopy services, rigorous HIV testing, and improved diagnosis of smear-negative TB.
C1 [van't Hoog, Anna H.] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol KEBB, NL-1100 DD Amsterdam, Netherlands.
[van't Hoog, Anna H.; Laserson, Kayla F.; Agaya, Janet A.; Odeny, Lazarus O.; Muchiri, Benson G.] Res & Publ Hlth Collaborat, Ctr Dis Control & Prevent, Kenya Med Res Inst, Kisumu, Kenya.
[Laserson, Kayla F.; Marston, Barbara J.; DeCock, Kevin M.] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA USA.
[Githui, Willie A.; Meme, Helen K.] Ctr Resp Dis Res, Kenya Med Res Inst, Nairobi, Kenya.
[DeCock, Kevin M.] Ctr Dis Control & Prevent, Nairobi, Kenya.
RP van't Hoog, AH (reprint author), Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol KEBB, J1B-207-1,POB 22660, NL-1100 DD Amsterdam, Netherlands.
EM a.h.vanthoog@amc.uva.nl
FU United States Agency for International Development (USAID) through
John's Hopkins University; Gates Foundation; European and Developing
Partners Clinical Trials Partenership
FX Supported by the U.S. President's Emergency Plan for AIDS Relief
(PEPFAR) the United States Agency for International Development (USAID)
through John's Hopkins University. Protocol development was supported by
the Gates Foundation.; A.H.v.H. has received a sponsored grant from the
European and Developing Partners Clinical Trials Partenership. K.F.L.
does not have a financial relationship with a commercial entity that has
an interest in the subject of this manuscript. W.A.G. does not have a
financial relationship with a commercial entity that has an interest in
the subject of this manuscript. H.K.M. does not have a financial
relationship with a commercial entity that has an interest in the
subject of this manuscript. J.A.A. does not have a financial
relationship with a commercial entity that has an interest in the
subject of this manuscript. L.O.O. does not have a financial
relationship with a commercial entity that has an interest in the
subject of this manuscript. B.G.M. does not have a financial
relationship with a commercial entity that has an interest in the
subject of this manuscript. B.J.M. is an employee of President's
Emergency Plan for AIDS Relief/U.S. Centers for Disease Control and
Prevention. K.M.D. does not have a financial relationship with a
commercial entity that has an interest in the subject of this
manuscript. M.W.B. does not have a financial relationship with a
commercial entity that has an interest in the subject of this
manuscript.
NR 50
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U1 1
U2 7
PU AMER THORACIC SOC
PI NEW YORK
PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA
SN 1073-449X
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD MAY 1
PY 2011
VL 183
IS 9
BP 1245
EP 1253
DI 10.1164/rccm.201008-1269OC
PG 9
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA 756IO
UT WOS:000290005100021
PM 21239690
ER
PT J
AU Mei, ZG
Grummer-Strawn, LM
AF Mei, Zuguo
Grummer-Strawn, Laurence M.
TI Comparison of Changes in Growth Percentiles of US Children on CDC 2000
Growth Charts With Corresponding Changes on WHO 2006 Growth Charts
SO CLINICAL PEDIATRICS
LA English
DT Article
DE growth charts; nutritional assessment; length-for-age; weight-for-age;
weight-for-length; percentile
ID STANDARDS; FAILURE; HEIGHT; HEALTH; THRIVE
AB Longitudinal data with 37 964 length and weight measurements from 10 844 children who participated in the California Child Health and Development Study was used to compare the proportion of children aged <= 24 months who crossed major percentile lines on the Centers for Disease Control and Prevention (CDC) 2000 growth charts with the percentage who crossed corresponding lines on the World Health Organization (WHO) 2006 growth charts. Percentage of children aged <= 24 months who crossed at least 2 major percentile lines for length-for-age, weight-for-age, and weight-for-length according to CDC 2000 charts were compared with the percentage who did so according to WHO 2006 charts. The results from this analysis suggest that pediatricians who monitor children's growth on the basis of WHO 2006 growth charts may be more likely to refer children aged < 6 months and less likely to refer those aged 6 to 12 months for further evaluation for failure to thrive.
C1 [Mei, Zuguo; Grummer-Strawn, Laurence M.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA.
RP Mei, ZG (reprint author), Ctr Dis Control & Prevent, Mailstop K-25,4770 Buford Highway, Atlanta, GA 30341 USA.
EM zmei@.cdc.gov
FU NICHD NIH HHS [N01HD63258]
NR 20
TC 9
Z9 10
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0009-9228
J9 CLIN PEDIATR
JI Clin. Pediatr.
PD MAY
PY 2011
VL 50
IS 5
BP 402
EP 407
DI 10.1177/0009922810392774
PG 6
WC Pediatrics
SC Pediatrics
GA 755RX
UT WOS:000289955200004
PM 21242198
ER
PT J
AU Foltz, JL
Cook, SR
Szilagyi, PG
Auinger, P
Stewart, PA
Bucher, S
Baldwin, CD
AF Foltz, Jennifer L.
Cook, Stephen R.
Szilagyi, Peter G.
Auinger, Peggy
Stewart, Patricia A.
Bucher, Sophie
Baldwin, Constance D.
TI US Adolescent Nutrition, Exercise, and Screen Time Baseline Levels Prior
to National Recommendations
SO CLINICAL PEDIATRICS
LA English
DT Article
DE obesity; adolescent; prevention and treatment; nutrition; physical
activity
ID BODY-MASS INDEX; PHYSICAL-ACTIVITY; CHILDHOOD OBESITY; OVERWEIGHT;
CHILDREN; WEIGHT; PREVENTION; TELEVISION; ASSOCIATION; BEVERAGES
AB Experts have recommended daily obesity prevention goals: >= 5 fruits/vegetables, < 2 hours of screen time, > 1 hour of physical activity, and no sugar-sweetened beverages (5-2-1-0). The authors analyzed National Health and Nutrition Examination Survey data for 1999-2002 to determine the proportion of US adolescents (12-19 years) who would have met each goal prior to dissemination of the 5-2-1-0 recommendations. Merely 0.4% would have met all goals; 41% would have met none. Only 9% consumed >= 5 fruits/vegetables, 27% reported < 2 hours of screen time, 32% had > 1 hour of physical activity, and 14% consumed no sugar-sweetened beverages per day. Demographic subgroups (eg, racial/ethnic minority and lower income) would have been even farther from meeting the goals. Clinicians are likely to encounter adolescents with nutrition, exercise, and screen time behaviors that are far from 5-2-1-0 goals, and can use these guidelines during clinical encounters to counsel adolescents regarding healthier lifestyles.
C1 [Foltz, Jennifer L.; Cook, Stephen R.; Szilagyi, Peter G.; Auinger, Peggy; Stewart, Patricia A.; Bucher, Sophie; Baldwin, Constance D.] Univ Rochester, Sch Med & Dent, Rochester, NY USA.
RP Foltz, JL (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway NE,MS K25, Atlanta, GA 30341 USA.
EM jfoltz@cdc.gov
RI Loureiro, Nuno/I-6400-2012
OI Loureiro, Nuno/0000-0002-1166-3219
FU NIH [T32 HP12002]; University of Rochester Strong Children's Research
Center
FX The authors disclosed receipt of the following financial support for the
research and/or authorship of this article:; This study was supported in
part by an institutional National Research Service Award (NIH Training
Grant T32 HP12002 to Dr Foltz) and by the University of Rochester Strong
Children's Research Center Bradford Fellowship Award (to Dr Foltz).
NR 37
TC 15
Z9 15
U1 0
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0009-9228
J9 CLIN PEDIATR
JI Clin. Pediatr.
PD MAY
PY 2011
VL 50
IS 5
BP 424
EP 433
DI 10.1177/0009922810393499
PG 10
WC Pediatrics
SC Pediatrics
GA 755RX
UT WOS:000289955200007
PM 21282256
ER
PT J
AU Soucie, JM
Wang, C
Forsyth, A
Funk, S
Denny, M
Roach, KE
Boone, D
AF Soucie, J. M.
Wang, C.
Forsyth, A.
Funk, S.
Denny, M.
Roach, K. E.
Boone, D.
CA Hemophilia Treatment Ctr Network
TI Range of motion measurements: reference values and a database for
comparison studies
SO HAEMOPHILIA
LA English
DT Article
DE joint flexibility; joint range of motion; musculoskeletal system;
reference values
ID BODY-MASS INDEX; JOINT RANGE; AGE; ANKLE; HIP; SHOULDER; MOBILITY;
CHILDREN; GENDER; ADOLESCENTS
AB Many diseases and injuries can impair joint mobility. Normal reference values are needed to determine extent of impairment to assess and monitor joint motion. There is very little published data describing normal joint range of motion (ROM) for healthy men and women across a wide span of ages. We enrolled male and female subjects aged between 2 and 69 years who were free from conditions that could potentially limit joint mobility for the study. Nine licensed physical therapists used universal goniometers to determine passive joint motion bilaterally of elbow flexion, extension, supination and pronation, shoulder flexion, hip flexion and extension, knee flexion and extension, and ankle dorsiflexion and plantarflexion. Descriptive statistics were calculated for male and female subjects in four age groups: 2-8, 9-19, 20-44 and 45-69 years. Joint ROM measurements were obtained on a total of 674 (53.6% female) healthy, normal subjects aged 2-69 years. Female subjects had greater joint mobility in all age groups in nearly all joints and the gender difference was most obvious in measures of ankle plantarflexion, elbow pronation and supination. Range of motion average values for all joints decreased with advancing age for both men and women and, in most cases, were significantly different than most commonly used normative values. Our study of ROM measurements taken by trained physical therapists on a large sample of healthy individuals revealed significant gender- and age-related variation that may be an important consideration in patient assessment.
C1 [Soucie, J. M.; Wang, C.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Div Blood Disorders, Atlanta, GA 30333 USA.
[Forsyth, A.; Denny, M.] Univ Penn, Med Ctr, Philadelphia, PA 19104 USA.
[Funk, S.] Univ Colorado Denver, Aurora, CO USA.
[Roach, K. E.] Univ Miami, Dept Phys Therapy, Coral Gables, FL 33124 USA.
RP Soucie, JM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Div Blood Disorders, 1600 Clifton Rd MS E64, Atlanta, GA 30333 USA.
EM msoucie@cdc.gov
RI Kerlin, Bryce/E-3369-2011
OI Kerlin, Bryce/0000-0002-1756-8271
FU Centers for Disease Control and Prevention; Health Resources and
Services Administration of the U.S. Department of Health and Human
Services
FX This was a collaborative project that involved many individuals from the
Hemophilia Treatment Center Network (HTCN) supported by cooperative
agreements with the Centers for Disease Control and Prevention and the
Health Resources and Services Administration of the U.S. Department of
Health and Human Services. The authors would like to acknowledge Crystal
Watson whose project coordination made this study possible. In addition
to authors (A. F., S. M. F, M. D.), the physical therapists and trainers
involved in the reliability assessment and making the measurements on
healthy volunteers included Kris Albrecht, PT, PCS, Michelle Audet, PT,
Gina Betley, PT, Amy Devening, PT, Carrie Hope, PT, Lynette Slovensky,
PT and Irene Vlaskamp, PT. The following individuals assisted with
grants management and/or recruitment of subjects for the study: Judith
Baker, MHSA, Becki Berkowitz, RN, Pam Bryant, Sue Cutter, MSW, MPA,
Patricia Dominic, Karen Droze, Cheryl Forsyth, Susan Geraghty, RN, MBA,
Sally McAlister, RN, Brenda Riske, MS, MBA, MPA, Mariam Voutsis, RN, MPA
and Angela Ward, BSN. The authors express their special thanks to the
healthy volunteers who agreed to have their joints measured.
NR 30
TC 75
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U1 3
U2 38
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-8216
EI 1365-2516
J9 HAEMOPHILIA
JI Haemophilia
PD MAY
PY 2011
VL 17
IS 3
BP 500
EP 507
DI 10.1111/j.1365-2516.2010.02399.x
PG 8
WC Hematology
SC Hematology
GA 754YQ
UT WOS:000289894200018
PM 21070485
ER
PT J
AU Kelly, D
Zhang, C
Soucie, M
Dimichele, D
AF Kelly, Daniel
Zhang, Cathy
Soucie, Michael
Dimichele, Donna
CA Joint Outcome Subcomm Coordinating
TI Prevalence of hip arthropathy in hemophilia A and B: An analysis of the
UDC database
SO HAEMOPHILIA
LA English
DT Meeting Abstract
C1 [Kelly, Daniel; Dimichele, Donna] Weill Cornell Med Coll, New York, NY USA.
[Zhang, Cathy; Soucie, Michael] CDC, Natl Birth Defects Ctr & Dev Disabilit, Div Blood Disorders, Atlanta, GA 30333 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1351-8216
J9 HAEMOPHILIA
JI Haemophilia
PD MAY
PY 2011
VL 17
IS 3
BP 556
EP 557
PG 2
WC Hematology
SC Hematology
GA 754YQ
UT WOS:000289894200039
ER
PT J
AU Guh, S
Grosse, SD
Mcalister, S
Kessler, CM
Soucie, JM
AF Guh, Soyeon
Grosse, Scott D.
Mcalister, Sally
Kessler, Craig M.
Soucie, J. Michael
TI Costs of care for privately insured males with hemophilia in the United
States, 2008
SO HAEMOPHILIA
LA English
DT Meeting Abstract
C1 [Guh, Soyeon; Grosse, Scott D.; Mcalister, Sally; Soucie, J. Michael] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Kessler, Craig M.] Georgetown Univ, Med Ctr, Washington, DC 20007 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1351-8216
J9 HAEMOPHILIA
JI Haemophilia
PD MAY
PY 2011
VL 17
IS 3
BP 565
EP 566
PG 2
WC Hematology
SC Hematology
GA 754YQ
UT WOS:000289894200078
ER
PT J
AU Guh, S
Grosse, SD
Mcalister, S
Kessler, CM
Soucie, JM
AF Guh, Soyeon
Grosse, Scott D.
Mcalister, Sally
Kessler, Craig M.
Soucie, J. Michael
TI Costs of care for publicly insured males with hemophilia in the United
States, 2008
SO HAEMOPHILIA
LA English
DT Meeting Abstract
C1 [Guh, Soyeon; Grosse, Scott D.; Mcalister, Sally; Soucie, J. Michael] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA.
[Kessler, Craig M.] Georgetown Univ, Med Ctr, Washington, DC 20007 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1351-8216
J9 HAEMOPHILIA
JI Haemophilia
PD MAY
PY 2011
VL 17
IS 3
BP 566
EP 566
PG 1
WC Hematology
SC Hematology
GA 754YQ
UT WOS:000289894200079
ER
PT J
AU Lutter, CK
Chaparro, CM
Grummer-Strawn, LM
AF Lutter, Chessa K.
Chaparro, Camila M.
Grummer-Strawn, Laurence M.
TI Increases in breastfeeding in Latin America and the Caribbean: an
analysis of equity
SO HEALTH POLICY AND PLANNING
LA English
DT Article
DE Breastfeeding; equity; Latin America; Caribbean
ID CHILD UNDERNUTRITION; INFECTIOUS-DISEASES; HEALTH; MORTALITY; DURATION;
INITIATION; COUNTRIES; INFANT; RISK; NUTRITION
AB Methods We use nationally representative data from eight countries in Latin America and the Caribbean to document changes in breastfeeding duration between 1986 and 2005, and separate the overall change into the portion attributable to changing population characteristics and the portion resulting from changing breastfeeding behaviour within population subgroups.
Results Breastfeeding duration increased in six out of the eight countries and the changes observed are largely explained by changing behaviour within population subgroups rather than changing population characteristics. Changes in breastfeeding duration did not tend to be equitably distributed, but in four countries (Bolivia, Brazil, Colombia and Peru) the population subgroups whose children are most at risk for mortality and increased morbidity from not being breastfed were least likely to show improvements in breastfeeding duration. Between 1986 and 2004 in Peru, breastfeeding duration declined by 0.6 months among rural women while increasing by 9.7 months among urban women; it increased by 6.3 months among women with prenatal care but only by 3.7 months among women with no prenatal care. Changes in breastfeeding in Guatemala and Haiti tended to favour the well-off compared with the poor, though not consistently. In Nicaragua changes in breastfeeding duration tended to favour the less well-off.
Discussion While promoting breastfeeding is a must for all women, to maximize its benefits for child survival and health, additional efforts are needed to reach poorly educated and rural women with little access to health care.
C1 [Lutter, Chessa K.] Pan Amer Hlth Org, Family & Community Hlth, Washington, DC 20037 USA.
[Chaparro, Camila M.] Acad Educ Dev, Washington, DC USA.
[Grummer-Strawn, Laurence M.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA.
RP Lutter, CK (reprint author), Pan Amer Hlth Org, Family & Community Hlth, 525 23rd St,NW, Washington, DC 20037 USA.
EM lutterch@paho.org
NR 32
TC 10
Z9 12
U1 1
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1080
J9 HEALTH POLICY PLANN
JI Health Policy Plan.
PD MAY
PY 2011
VL 26
IS 3
BP 257
EP 265
DI 10.1093/heapol/czq046
PG 9
WC Health Care Sciences & Services; Health Policy & Services
SC Health Care Sciences & Services
GA 754EQ
UT WOS:000289836700007
PM 20876642
ER
PT J
AU Lonsway, DR
Urich, SK
Heine, HS
McAllister, SK
Banerjee, SN
Schriefer, ME
Patel, JB
AF Lonsway, David R.
Urich, Sandra K.
Heine, Henry S.
McAllister, Sigrid K.
Banerjee, Shailen N.
Schriefer, Martin E.
Patel, Jean B.
TI Comparison of Etest Method with Reference Broth Microdilution Method for
Antimicrobial Susceptibility Testing of Yersinia pestis
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Article
ID TRANSFERABLE PLASMID; PLAGUE; AGENTS; RESISTANCE; STRAINS
AB The utility of Etest for antimicrobial susceptibility testing of Yersinia pestis was evaluated in comparison with broth microdilution and disk diffusion for eight agents. Four laboratories tested 26 diverse strains and found Etest to be reliable for testing antimicrobial agents used to treat Y. pestis, except for chloramphenicol and trimethoprim-sulfamethoxazole. Disk diffusion testing is not recommended.
C1 [Lonsway, David R.; McAllister, Sigrid K.; Banerjee, Shailen N.; Patel, Jean B.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
[Urich, Sandra K.; Schriefer, Martin E.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA.
[Heine, Henry S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Lonsway, DR (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Mailstop G08,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM dul7@cdc.gov
NR 25
TC 3
Z9 3
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD MAY
PY 2011
VL 49
IS 5
BP 1956
EP 1960
DI 10.1128/JCM.00142-11
PG 5
WC Microbiology
SC Microbiology
GA 755OA
UT WOS:000289941000038
PM 21411569
ER
PT J
AU Mercado, E
Srinivasan, V
Hawkins, P
Chochua, S
Ochoa, T
Beall, B
Mcgee, L
AF Mercado, Erik
Srinivasan, Velusamy
Hawkins, Paulina
Chochua, Sopio
Ochoa, Theresa
Beall, Bernard
McGee, Lesley
TI First Report of Streptococcus pneumoniae Serotype 6D in South America
SO JOURNAL OF CLINICAL MICROBIOLOGY
LA English
DT Letter
ID 6C; CHILDREN; 6A; 6B
C1 [Mercado, Erik; Ochoa, Theresa] Univ Peruana Cayetano Heredia, Inst Trop Med, Lima, Peru.
[Srinivasan, Velusamy; Beall, Bernard; McGee, Lesley] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA USA.
[Hawkins, Paulina; Chochua, Sopio] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
RP Mercado, E (reprint author), Univ Peruana Cayetano Heredia, Inst Trop Med, Lima, Peru.
EM lmcgee@cdc.gov
OI , ERIK/0000-0003-0899-521X
NR 10
TC 11
Z9 11
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0095-1137
J9 J CLIN MICROBIOL
JI J. Clin. Microbiol.
PD MAY
PY 2011
VL 49
IS 5
BP 2080
EP 2081
DI 10.1128/JCM.00153-11
PG 2
WC Microbiology
SC Microbiology
GA 755OA
UT WOS:000289941000072
PM 21430101
ER
PT J
AU Zeng, G
Ma, HL
Wang, XB
Yan, HF
Wan, XH
Jiang, B
Fontaine, RE
Wu, ZL
Lin, SB
Ruan, F
Liu, HH
AF Zeng, Guang
Ma, Huilai
Wang, Xiangbo
Yan, Huifang
Wan, Xinhua
Jiang, Bin
Fontaine, Robert E.
Wu, Zhenglai
Lin, Shaobin
Ruan, Feng
Liu, Huihui
TI Paraplegia and Paraparesis From Intrathecal Methotrexate and Cytarabine
Contaminated With Trace Amounts of Vincristine in China During 2007
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID ACUTE LYMPHOBLASTIC-LEUKEMIA; CHEMOTHERAPY; INJECTION; MYELOPATHY
AB Purpose The production and administration of drugs used intrathecally requires special care to prevent contamination with neurotoxic agents. In 2007, we investigated a widespread outbreak of paraplegia and paraparesis among Chinese patients who received intrathecal drugs to identify the presumed contaminant and its source to prevent further cases.
Patients and Methods We defined a case as onset from January 1 to October 31, 2007, of bilateral flaccid paraparesis or paraplegia or retention and incontinence of stool or urine, in a patient receiving intrathecal drugs. Using a retrospective cohort approach, we selected 12 hospitals from all hospitals that had reported cases. In these hospitals, we identified all 448 patients (including 107 cases) who received intrathecal chemotherapy or chemoprophylaxis in 2007. We calculated attack rates and Mantel-Haenszel adjusted risk ratios for intrathecal drug type and lot.
Results All 12 hospitals used intrathecal methotrexate or cytarabine produced by one pharmaceutical plant. Only two lots of each drug were associated with cases. Lot-specific attack rates ranged from 42% to 100% (risk ratio, infinity; lower confidence bounds, 1.8 to 7.3). Vincristine production had immediately preceded production of the implicated lots on the same equipment. By using ultra performance liquid chromatography, we detected vincristine (0.28 to 18 mu g) in unused vials from implicated lots of methotrexate and cytarabine.
Conclusion Trace amounts of vincristine that contaminated intrathecal drugs caused a large outbreak of severe neurologic damage. Vincristine and other neurotoxic drugs should not be produced on any equipment that is also used for producing drugs that are to be administered intrathecally.
C1 [Zeng, Guang] Chinese Ctr Dis Control & Prevent, Chinese Field Epidemiol Training Program, Beijing 100050, Peoples R China.
Natl Inst Occupat Hlth & Poison Control, Beijing, Peoples R China.
Natl Inst Environm Hlth & Related Product Safety, Beijing, Peoples R China.
Capital Med Univ, Xuan Wu Hosp, Beijing, Peoples R China.
Peking Union Med Coll, Beijing 100021, Peoples R China.
Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China.
Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Zeng, G (reprint author), Chinese Ctr Dis Control & Prevent, Chinese Field Epidemiol Training Program, 27 Nanwei Rd, Beijing 100050, Peoples R China.
EM zeng4605@vip.sina.com
NR 25
TC 0
Z9 1
U1 0
U2 2
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 1
PY 2011
VL 29
IS 13
BP 1765
EP 1770
DI 10.1200/JCO.2010.32.7072
PG 6
WC Oncology
SC Oncology
GA 757MN
UT WOS:000290090400034
PM 21422429
ER
PT J
AU Wen, XJ
Balluz, L
AF Wen, Xiao Jun
Balluz, Lina
TI Association Between Presence of Visible In-House Mold and Health-Related
Quality of Life in Adults Residing in Four U.S. States
SO JOURNAL OF ENVIRONMENTAL HEALTH
LA English
DT Article
ID PULMONARY-DISEASE; HOME DAMPNESS; EXPOSURE; SYMPTOMS; ASTHMA; HRQOL;
FUNGI
AB Despite the broad use of health-related quality of life (IIRQOL) as one of the measurements to assess health status and effectiveness of health care and interventions, the impact of in-house mold exposure on IIRQOL is unknown. The study described in this article examined the relationship between presence of visible in-house mold (PVIM) and HRQOL among adults. Data were analyzed from the 2005 and 2006 Behavioral Risk Factor Surveillance System (BRFSS) surveys that consisted of a random cross-sectional sample of 18,356 adults in four states. The authors examined the relationship between PVIM and three important indicators of the HRQOL by logistic regression analyses. Their results suggest that PVIM is independently associated with the indicators of HRQOL including mentally unhealthy, physically unhealthy, and total unhealthy days. Therefore, implementation of appropriate measures at the household level to eliminate or reduce in-house mold may improve individuals' HRQOL.
C1 [Wen, Xiao Jun] Ctr Dis Control & Prevent, Clin Outcomes Team, Behav & Clin Surveillance Branch, Div HIV AIDS Prevent, Atlanta, GA 30333 USA.
RP Wen, XJ (reprint author), Ctr Dis Control & Prevent, Clin Outcomes Team, Behav & Clin Surveillance Branch, Div HIV AIDS Prevent, 1600 Clifton Rd NE,MS E46, Atlanta, GA 30333 USA.
EM tzw4@cdc.gov
NR 25
TC 1
Z9 1
U1 0
U2 1
PU NATL ENVIRON HEALTH ASSOC
PI DENVER
PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA
SN 0022-0892
J9 J ENVIRON HEALTH
JI J. Environ. Health
PD MAY
PY 2011
VL 73
IS 9
BP 8
EP 14
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 755HP
UT WOS:000289920000002
PM 21644480
ER
PT J
AU Butz, AM
Breysse, P
Rand, C
Curtin-Brosnan, J
Eggleston, P
Diette, GB
Williams, D
Bernert, JT
Matsui, EC
AF Butz, Arlene M.
Breysse, Patrick
Rand, Cynthia
Curtin-Brosnan, Jean
Eggleston, Peyton
Diette, Gregory B.
Williams, D'Ann
Bernert, John T.
Matsui, Elizabeth C.
TI Household Smoking Behavior: Effects on Indoor Air Quality and Health of
Urban Children with Asthma
SO MATERNAL AND CHILD HEALTH JOURNAL
LA English
DT Article
DE Asthma; Children; Cotinine; Particulate matter; Air Nicotine
ID ENVIRONMENTAL TOBACCO-SMOKE; INNER-CITY CHILDREN; LOW-INCOME; PARENTAL
SMOKING; URINARY COTININE; RANDOMIZED-TRIAL; UNITED-STATES; EXPOSURE;
INTERVENTION; NONSMOKERS
AB The goal of the study was to examine the association between biomarkers and environmental measures of second hand smoke (SHS) with caregiver, i.e. parent or legal guardian, report of household smoking behavior and morbidity measures among children with asthma. Baseline data were drawn from a longitudinal intervention for 126 inner city children with asthma, residing with a smoker. Most children met criteria for moderate to severe persistent asthma (63%) versus mild intermittent (20%) or mild persistent (17%). Household smoking behavior and asthma morbidity were compared with child urine cotinine and indoor measures of air quality including fine particulate matter (PM(2.5)) and air nicotine (AN). Kruskal-Wallis, Wilcoxon rank-sum and Spearman rho correlation tests were used to determine the level of association between biomarkers of SHS exposure and household smoking behavior and asthma morbidity. Most children had uncontrolled asthma (62%). The primary household smoker was the child's caregiver (86/126, 68%) of which 66 (77%) were the child's mother. Significantly higher mean PM(2.5), AN and cotinine concentrations were detected in households where the caregiver was the smoker (caregiver smoker: PM(2.5) mu g/m(3): 44.16, AN: 1.79 mu g/m(3), cotinine: 27.39 ng/ml; caregiver non-smoker: PM(2.5): 28.88 mu g/m(3), AN: 0.71 mu g/m(3), cotinine:10.78 ng/ml, all P <= 0.01). Urine cotinine concentrations trended higher in children who reported 5 or more symptom days within the past 2 weeks (> 5 days/past 2 weeks, cotinine: 28.1 ng/ml vs. < 5 days/past 2 weeks, cotinine: 16.2 ng/ml; P = 0.08). However, environmental measures of SHS exposures were not associated with asthma symptoms. Urban children with persistent asthma, residing with a smoker are exposed to high levels of SHS predominantly from their primary caregiver. Because cotinine was more strongly associated with asthma symptoms than environmental measures of SHS exposure and is independent of the site of exposure, it remains the gold standard for SHS exposure assessment in children with asthma.
C1 [Butz, Arlene M.] Johns Hopkins Univ, Sch Med, Div Gen Pediat, Baltimore, MD 21287 USA.
[Breysse, Patrick; Williams, D'Ann] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Environm Hlth, Baltimore, MD 21287 USA.
[Rand, Cynthia; Diette, Gregory B.] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, Baltimore, MD 21287 USA.
[Curtin-Brosnan, Jean; Eggleston, Peyton; Matsui, Elizabeth C.] Johns Hopkins Univ, Sch Med, Div Pediat Allergy & Immunol, Baltimore, MD 21287 USA.
[Bernert, John T.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA USA.
RP Butz, AM (reprint author), Johns Hopkins Univ, Sch Med, Div Gen Pediat, 200 N Wolfe St, Baltimore, MD 21287 USA.
EM abutz@jhmi.edu
FU NIEHS NIH HHS [P01 ES009606-09, P01 ES009606]; PHS HHS [E09606]
NR 46
TC 25
Z9 25
U1 1
U2 9
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1092-7875
J9 MATERN CHILD HLTH J
JI Matern. Child Health J.
PD MAY
PY 2011
VL 15
IS 4
BP 460
EP 468
DI 10.1007/s10995-010-0606-7
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 753AS
UT WOS:000289737200006
PM 20401688
ER
PT J
AU Hickson, DA
Burchfiel, CM
Petrini, MF
Liu, JK
Campbell-Jenkins, BW
Bhagat, R
Marshall, GD
AF Hickson, DeMarc A.
Burchfiel, Cecil M.
Petrini, Marcy F.
Liu, Jiankang
Campbell-Jenkins, Brenda W.
Bhagat, Rajesh
Marshall, Gailen D.
TI Leptin Is Inversely Associated With Lung Function in African Americans,
Independent of Adiposity: The Jackson Heart Study
SO OBESITY
LA English
DT Article
ID LEFT-VENTRICULAR HYPERTROPHY; PULMONARY-FUNCTION; UNITED-STATES;
CARDIOVASCULAR-DISEASE; ATHEROSCLEROSIS RISK; VITAL CAPACITY; PLASMA
LEPTIN; SERUM LEPTIN; POPULATION; MORTALITY
AB Leptin, a 16-kDa protein, has proinflammatory properties and has been linked to respiratory physiological responses in majority white populations. Little is known, however, about the relationship of leptin with lung function in nonwhites. Cross-sectional associations of circulating serum leptin concentrations with forced expiratory volume in 1 s (FEV(1)), FEV in 6 s (FEV(6)), and vital capacity (FVC), assessed by spirometry, were examined in 4,679 African-American men and women participants (54.3 +/- 12.4 years; 62.7% women) in the Jackson Heart Study (JHS). The independent association of leptin was examined in relation to FEV(1), FEV(6), and FVC% predicted after adjustment for age, education, smoking status, pack-years of cigarette smoking, respiratory medication use, and menopausal status in women; additional adjustment included total body weight, waist circumference, and BMI. Serum leptin was inversely related to FEV(1), FEV(6), and FVC% predicted values in men. A dose-response relationship was observed with men in the highest leptin quartile having a significantly lower lung function compared to men in the lower leptin quartile. BMI significantly modified this relationship in women: leptin was most consistently associated with lung function in obese women, less consistent in overweight women, and absent in normal-weight women. Serum leptin concentration was strongly, inversely, and independently associated with lung function in African Americans, especially African-American men and obese women.
C1 [Hickson, DeMarc A.; Campbell-Jenkins, Brenda W.] Jackson State Univ, Jackson Heart Study, Jackson, MS USA.
[Hickson, DeMarc A.; Liu, Jiankang; Marshall, Gailen D.] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA.
[Burchfiel, Cecil M.] NIOSH, Ctr Dis Control & Prevent, Hlth Effects Lab Div, Morgantown, WV USA.
[Petrini, Marcy F.; Bhagat, Rajesh] Univ Mississippi, Med Ctr, Div Pulm Crit Care & Sleep Med, Jackson, MS 39216 USA.
[Bhagat, Rajesh] Sonny Montgomery Vet Affairs Hosp, Jackson, MS USA.
RP Hickson, DA (reprint author), Jackson State Univ, Jackson Heart Study, Jackson, MS USA.
EM demarc.a.hickson@jsums.edu
FU National Institutes of Health: National Heart Lung & Blood Institute and
National Center on Minority Health and Health Disparities [N01-HC-95170,
N01-HC-95171, N01-HC-95172]
FX We give sincere thanks to the Jackson Heart Study participants, staff,
and interns for their long-term commitment to the study. The findings
and conclusions in this report are those of the authors and do not
necessarily represent the views of the Nationals Institutes of Health or
the National Institute for Occupational Safety and Health. This work was
supported by National Institutes of Health: National Heart Lung & Blood
Institute and National Center on Minority Health and Health Disparities
(contracts N01-HC-95170, N01-HC-95171, and N01-HC-95172).
NR 54
TC 6
Z9 6
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD MAY
PY 2011
VL 19
IS 5
BP 1054
EP 1061
DI 10.1038/oby.2010.240
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 755LS
UT WOS:000289933300026
PM 20966906
ER
PT J
AU Taylor, LD
Hariri, S
Sternberg, M
Dunne, EF
Markowitz, LE
AF Taylor, La'Shan D.
Hariri, Susan
Sternberg, Maya
Dunne, Eileen F.
Markowitz, Lauri E.
TI Human papillomavirus vaccine coverage in the United States, National
Health and Nutrition Examination Survey, 2007-2008
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Human papillomavirus vaccine; National Health and Nutrition Examination
Survey; Vaccine coverage
ID INFECTION; WOMEN
AB Objectives. This study aims to estimate human papillomavirus (HPV) vaccine coverage by demographic and sexual behavior characteristics 1-2 years after vaccine licensure in a nationally representative sample of females aged 9-59 years in the United States.
Methods. In 2007-2008, a total of 2775 females aged 9-59 years responded to questions on HPV vaccine receipt in the National Health and Nutrition Examination Survey (NHANES). Demographic and sexual characteristics were evaluated for select age categories in bivariate analyses after adjusting for survey design.
Results. Overall, 15.2% of females aged 11-26 years reported HPV vaccine initiation; vaccine initiation varied significantly by age. We found no significant difference in vaccine initiation by race or poverty level in either 1118 or 19-26-year olds. Significantly more 19-26-year olds with private insurance initiated vaccine (16.3%) than those with public insurance (4.0%) (p = 0.04). Among females aged 14-18 years, vaccine initiation was higher in those who ever had sex (28.6%) compared to those who had never had sex (17.8%) (p = 0.05).
Conclusions. These results describe HPV vaccine initiation shortly after vaccine licensure. Vaccine initiation was highest in females aged 14-18 years. Efforts should be made to increase HPV vaccine coverage for the recommended age groups. Published by Elsevier Inc.
C1 [Taylor, La'Shan D.; Hariri, Susan; Dunne, Eileen F.; Markowitz, Lauri E.] Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA.
[Sternberg, Maya] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA.
RP Taylor, LD (reprint author), Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE,Mailstop E-02, Atlanta, GA 30333 USA.
EM LDTaylor@cdc.gov
NR 15
TC 41
Z9 41
U1 1
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
J9 PREV MED
JI Prev. Med.
PD MAY 1
PY 2011
VL 52
IS 5
BP 398
EP 400
DI 10.1016/j.ypmed.2010.11.006
PG 3
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 757CO
UT WOS:000290062000021
PM 21108962
ER
PT J
AU Soteriades, ES
Spanoudis, G
Talias, MA
Warren, CW
DiFranza, JR
AF Soteriades, Elpidoforos S.
Spanoudis, George
Talias, Michael A.
Warren, Charles W.
DiFranza, Joseph R.
TI Children's loss of autonomy over smoking: the global youth tobacco
survey
SO TOBACCO CONTROL
LA English
DT Article
ID NICOTINE-DEPENDENCE SYMPTOMS; DIMINISHED AUTONOMY; ADOLESCENT SMOKERS;
CHECKLIST; WITHDRAWAL; CLASSIFICATION; TOLERANCE; ADULTS; ONSET; DANDY
AB Background Empirical data suggest that children with infrequent tobacco use have difficulty quitting smoking.
Methods Data were obtained from the nationally representative Global Youth Tobacco Survey of middle-school students in Cyprus and Greece. Regression analyses examined associations between smoking frequency (smoking days per month or cigarettes smoked per day) and loss of autonomy (difficulty refraining from smoking).
Results The prevalence of lost autonomy was 40% among subjects who smoked 1 or 2 days/month and 41% among subjects who averaged less than one cigarette/day and increased in a dose-response pattern. Regression models derived from the Cyprus data were replicated by the Greek data.
Conclusions Two national surveys confirm previous reports of difficulty with smoking cessation with infrequent smoking. Since loss of autonomy is universally recognised as a core feature of addiction, our data indicate that young adolescents experience symptoms of nicotine addiction with infrequent tobacco use.
C1 [DiFranza, Joseph R.] Univ Massachusetts, Sch Med, Dept Family Med & Community Hlth, Worcester, MA 01655 USA.
[Soteriades, Elpidoforos S.] CIBS, Dept Occupat & Environm Med, Nicosia, Cyprus.
[Soteriades, Elpidoforos S.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth Environm & Occupat Med & Epide, Boston, MA 02115 USA.
[Spanoudis, George] Univ Cyprus, Dept Psychol, Nicosia, Cyprus.
[Talias, Michael A.] Open Univ Cyprus, Healthcare Management Program, Nicosia, Cyprus.
[Warren, Charles W.] Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, Atlanta, GA 30333 USA.
RP DiFranza, JR (reprint author), Univ Massachusetts, Sch Med, Dept Family Med & Community Hlth, 55 Lake Ave, Worcester, MA 01655 USA.
EM difranzj@ummhc.org
FU Cyprus Ministry of Health; Greek Ministry of Health and Social
Solidarity; Office for Smoking and Health at the Centers for Disease
Control and Prevention; Centers for Disease Control
FX The authors would like to thank the officers at the Ministry of Health
in Cyprus and the Ministry of Health and Social Solidarity in Greece for
their support of the GYTS project. The study was supported by a grant
from the Cyprus Ministry of Health and the Greek Ministry of Health and
Social Solidarity. Considerable support was also received from the
Office for Smoking and Health at the Centers for Disease Control and
Prevention.; Centers for Disease Control.
NR 34
TC 8
Z9 8
U1 0
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-4563
EI 1468-3318
J9 TOB CONTROL
JI Tob. Control
PD MAY
PY 2011
VL 20
IS 3
BP 201
EP 206
DI 10.1136/tc.2010.036848
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 751KU
UT WOS:000289617200017
PM 21109683
ER
PT J
AU Koh, HK
Alpert, HR
Judge, CM
Caughey, RW
Elqura, LJ
Connolly, GN
Warren, CW
AF Koh, Howard K.
Alpert, Hillel R.
Judge, Christine M.
Caughey, Robert W.
Elqura, Loris J.
Connolly, Gregory N.
Warren, Charles W.
TI Understanding worldwide youth attitudes towards smoke-free policies: an
analysis of the Global Youth Tobacco Survey
SO TOBACCO CONTROL
LA English
DT Article
ID 4 COUNTRY SURVEY; ANTISMOKING ATTITUDES; SECONDHAND SMOKE; YOUNG-PEOPLE;
REGULATIONS; RESTAURANTS; PREVALENCE; INITIATION; BEHAVIORS; PATRONAGE
AB Background Smoke-free policies (SFPs) in public places are increasing globally, but developing countries are lagging behind. Understanding youth attitudes towards SFPs can inform SFP initiatives.
Methods A multilevel logistic regression analysis of data collected from youth aged 13-15 years (2000-2006) who completed the Global Youth Tobacco Survey (GYTS) in 115 countries, primarily in the developing world, was conducted. The analysis examined relationships between support for SFPs and individual-level measures related to smoking status, and exposure to secondhand smoke (SHS), controlling for demographic and environmental factors of interest and country-level policy factors.
Results In all, 77.3% of 356 395 youth in 115 countries favoured SFPs, including majorities of non-smokers (78.7%) and smokers (63.6%). In the multivariable analysis knowledge of smoke harm was the strongest predictor of favouring SFPs (OR 2.42, 95% CI 2.27 to 2.67). Exposure to countermarketing (OR 1.40, 95% CI 1.25 to 1.57) and school anti-smoking education (OR 1.22, 95% CI 1.13 to 1.31) were also positively associated. Current smoking (OR 0.48, 95% CI 0.41 to 0.53), susceptibility to smoking (OR 0.46, 95% CI 0.40 to 0.52) and exposure to tobacco promotion were negatively associated. Significant country-level variation was observed. The presence of any national smoke-free legislation in a country was positively associated with youth favouring such policies.
Conclusions The majority of youth worldwide support, yet lack, smoke-free policies in public places, while being regularly exposed to SHS. Youth support of SFPs is most positively associated with knowledge of the harmful effects of tobacco smoke. Redoubling education efforts represents an opportunity to establish smoke-free environments and improve health of children in developing countries.
C1 [Alpert, Hillel R.; Connolly, Gregory N.] Harvard Univ, Sch Publ Hlth, Ctr Global Tobacco Control, Boston, MA 02115 USA.
[Warren, Charles W.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA USA.
RP Alpert, HR (reprint author), Harvard Univ, Sch Publ Hlth, Ctr Global Tobacco Control, 401 Pk Dr,Landmark Ctr,3rd Floor E, Boston, MA 02115 USA.
EM halpert@hsph.harvard.edu
FU Flight Attendants Medical Research Institute
FX This paper was supported by a Flight Attendants Medical Research
Institute, Clinical Innovator Award 072085.
NR 37
TC 21
Z9 21
U1 2
U2 7
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-4563
J9 TOB CONTROL
JI Tob. Control
PD MAY
PY 2011
VL 20
IS 3
BP 219
EP 225
DI 10.1136/tc.2010.038885
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 751KU
UT WOS:000289617200020
PM 21270072
ER
PT J
AU McClave-Regan, AK
Berkowitz, J
AF McClave-Regan, Annette K.
Berkowitz, Judy
TI Smokers who are also using smokeless tobacco products in the US: a
national assessment of characteristics, behaviours and beliefs of 'dual
users'
SO TOBACCO CONTROL
LA English
DT Article
ID CIGARETTE-SMOKING; DISEASE; RISKS
AB Background Marketing and advertising of smokeless tobacco products towards cigarette smokers has increased recently. Because the use of multiple tobacco products is a growing public health concern, the present work assesses the use of smokeless tobacco among cigarette smokers, a behaviour termed as 'dual use', as well as attitudes and beliefs on their 'dual use' of tobacco.
Methods Data were used from the 2008 ConsumerStyles survey, a nationally representative, mail-in survey of consumers in the USA (n = 10 108).
Results 'Dual use' was more common among cigarette smokers who were young, white men living in the Midwest or South. The majority of 'dual users' reported using smokeless tobacco in places where they could not smoke (67.7%) and did not believe smokeless tobacco would help in quitting smoking (75.1%). 'Dual users' reported planning to quit within the next 6 months less often than adults who smoke cigarettes exclusively and close to half (42.3%) never plan to quit smoking.
Conclusions Tobacco use is attributed to a number of diseases and deaths worldwide, and cessation of tobacco use can reduce these health risks. The prevalent use of smokeless tobacco in places with smoking restrictions and lack of planning to quit by 'dual users' suggest the need to promote cessation among these users.
C1 [McClave-Regan, Annette K.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA.
RP McClave-Regan, AK (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, 4770 Buford Highway,Mailstop K-50, Atlanta, GA 30341 USA.
EM amcclave@cdc.gov
OI Regan, Annette/0000-0002-3879-6193
NR 23
TC 38
Z9 38
U1 0
U2 5
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-4563
J9 TOB CONTROL
JI Tob. Control
PD MAY
PY 2011
VL 20
IS 3
BP 239
EP 242
DI 10.1136/tc.2010.039115
PG 4
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 751KU
UT WOS:000289617200024
PM 21172853
ER
PT J
AU Stanfill, SB
Connolly, GN
Zhang, LQ
Jia, LT
Henningfield, JE
Richter, P
Lawler, TS
Ayo-Yusuf, OA
Ashley, DL
Watson, CH
AF Stanfill, Stephen B.
Connolly, Gregory N.
Zhang, Liqin
Jia, Lily T.
Henningfield, Jack E.
Richter, Patricia
Lawler, Tameka S.
Ayo-Yusuf, Olalekan A.
Ashley, David L.
Watson, Clifford H.
TI Global surveillance of oral tobacco products: total nicotine, unionised
nicotine and tobacco-specific N-nitrosamines
SO TOBACCO CONTROL
LA English
DT Article
ID SMOKELESS TOBACCO; MOIST SNUFF; CARCINOGEN; SMOKERS; SUDAN; USERS
AB Objective Oral tobacco products contain nicotine and carcinogenic tobacco-specific N-nitrosamines (TSNAs) that can be absorbed through the oral mucosa. The aim of this study was to determine typical pH ranges and concentrations of total nicotine, unionised nicotine (the most readily absorbed form) and five TSNAs in selected oral tobacco products distributed globally.
Methods A total of 53 oral tobacco products from 5 World Health Organisation (WHO) regions were analysed for total nicotine and TSNAs, including 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanol (NNAL), using gas chromatography or liquid chromatography with mass spectrometric detection. Unionised nicotine concentrations were calculated using product pH and total nicotine concentrations. Fourier transform infrared spectroscopy was used to help categorise or characterise some products.
Results Total nicotine content varied from 0.16 to 34.1 mg/g product, whereas, the calculated unionised nicotine ranged from 0.05 to 31.0 mg/g product; a 620-fold range of variation. Products ranged from pH 5.2 to 10.1, which translates to 0.2% to 99.1% of nicotine being in the unionised form. Some products have very high pH and correspondingly high unionised nicotine (eg, gul powder, chimo, toombak) and/or high TSNA (eg, toombak, zarda, khaini) concentrations. The concentrations of TSNAs spanned five orders of magnitude with concentrations of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) ranging from 4.5 to 516 000 ng/g product.
Conclusions These data have important implications for risk assessment because they show that very different exposure risks may be posed through the use of these chemically diverse oral tobacco products. Because of the wide chemical variation, oral tobacco products should not be categorised together when considering the public health implications of their use.
C1 [Stanfill, Stephen B.; Zhang, Liqin; Lawler, Tameka S.; Ashley, David L.; Watson, Clifford H.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Emergency Response & Air Toxicants Branch, Atlanta, GA 30341 USA.
[Connolly, Gregory N.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
[Jia, Lily T.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Organ Analyt Toxicol Branch, Atlanta, GA 30341 USA.
[Henningfield, Jack E.] Johns Hopkins Univ, Sch Med, Bethesda, MD USA.
[Henningfield, Jack E.] Pinney Associates, Bethesda, MD USA.
[Richter, Patricia] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, Atlanta, GA 30341 USA.
[Ayo-Yusuf, Olalekan A.] Univ Pretoria, Fac Hlth Sci, Dept Community Dent, ZA-0002 Pretoria, South Africa.
RP Stanfill, SB (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Emergency Response & Air Toxicants Branch, 4770 Buford Highway, Atlanta, GA 30341 USA.
EM sstanfill@cdc.gov
FU U.S. Government, Department of Health and Human Services; Centers for
Disease Control and Prevention, with U.S. federal government
FX This work was funded by the U.S. Government, Department of Health and
Human Services. This study was also funded internally at the Centers for
Disease Control and Prevention, with funds directly provided by the U.S.
federal government.
NR 25
TC 42
Z9 42
U1 1
U2 15
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0964-4563
J9 TOB CONTROL
JI Tob. Control
PD MAY
PY 2011
VL 20
IS 3
DI 10.1136/tc.2010.037465
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 751KU
UT WOS:000289617200001
PM 21109685
ER
PT J
AU Horton, JC
Yoon, MK
Carvalho, MD
McLeod, SD
AF Horton, Jonathan C.
Yoon, Michael K.
Carvalho, Maria D.
McLeod, Stephen D.
TI Polymerase chain reaction confirmed by immunohistochemistry: a
two-pronged diagnostic approach in endophthalmitis
SO ACTA OPHTHALMOLOGICA
LA English
DT Article
ID STREPTOCOCCUS-PNEUMONIAE
C1 [Horton, Jonathan C.] Univ Calif San Francisco, Beckman Vis Ctr, Dept Ophthalmol, San Francisco, CA 94143 USA.
[Carvalho, Maria D.] Ctr Dis Control & Prevent, Atlanta, GA USA.
RP Horton, JC (reprint author), Univ Calif San Francisco, Beckman Vis Ctr, Dept Ophthalmol, San Francisco, CA 94143 USA.
EM hortonj@vision.ucsf.edu
FU Research to Prevent Blindness
FX We thank Sherif R. Zaki, Melissa Whaley and Bernard Beall. This research
was supported by an unrestricted grant from Research to Prevent
Blindness.
NR 5
TC 2
Z9 2
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1755-375X
J9 ACTA OPHTHALMOL
JI Acta Ophthalmol.
PD MAY
PY 2011
VL 89
IS 3
BP 301
EP 302
DI 10.1111/j.1755-3768.2009.01643.x
PG 2
WC Ophthalmology
SC Ophthalmology
GA 751TR
UT WOS:000289641000038
PM 19681759
ER
PT J
AU O'Grady, NP
Alexander, M
Burns, LA
Dellinger, EP
Garland, J
Heard, SO
Lipsett, PA
Masur, H
Mermel, LA
Pearson, ML
Raad, II
Randolph, AG
Rupp, ME
Saint, S
AF O'Grady, Naomi P.
Alexander, Mary
Burns, Lillian A.
Dellinger, E. Patchen
Garland, Jeffrey
Heard, Stephen O.
Lipsett, Pamela A.
Masur, Henry
Mermel, Leonard A.
Pearson, Michele L.
Raad, Issam I.
Randolph, Adrienne G.
Rupp, Mark E.
Saint, Sanjay
CA HICPAC
TI Guidelines for the prevention of intravascular catheter-related
infections
SO AMERICAN JOURNAL OF INFECTION CONTROL
LA English
DT Article
ID CENTRAL VENOUS CATHETERS; BLOOD-STREAM INFECTION; INTENSIVE-CARE-UNIT;
RANDOMIZED CONTROLLED-TRIAL; PULMONARY-ARTERY CATHETERS; CRITICALLY-ILL
PATIENTS; TOTAL PARENTERAL-NUTRITION; COAGULASE-NEGATIVE STAPHYLOCOCCI;
PERIPHERAL INTRAVENOUS CATHETERS; CUFFED HEMODIALYSIS CATHETERS
C1 [O'Grady, Naomi P.; Masur, Henry] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA.
[Alexander, Mary] Infus Nurses Soc, Norwood, MA USA.
[Burns, Lillian A.] Staten Isl Univ Hosp, Staten Isl, NY USA.
[Dellinger, E. Patchen] Univ Washington, Dept Surg, Seattle, WA 98195 USA.
[Garland, Jeffrey] Wheaton Franciscan Healthcare St Joseph, Dept Pediat, Milwaukee, WI USA.
[Heard, Stephen O.] Univ Massachusetts, Sch Med, Dept Anesthesiol, Worcester, MA USA.
[Lipsett, Pamela A.] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21205 USA.
[Mermel, Leonard A.] Brown Univ, Div Infect Dis, Warren Alpert Med Sch, Providence, RI 02912 USA.
[Mermel, Leonard A.] Rhode Isl Hosp, Providence, RI USA.
[Pearson, Michele L.] CDC, Off Infect Dis, Atlanta, GA 30333 USA.
[Raad, Issam I.] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis, Houston, TX 77030 USA.
[Randolph, Adrienne G.] Childrens Hosp, Dept Anesthesiol, Boston, MA 02115 USA.
[Rupp, Mark E.] Univ Nebraska Med Ctr, Dept Internal Med, Omaha, NE USA.
[Saint, Sanjay] Univ Michigan, Ann Arbor, MI 48109 USA.
[Saint, Sanjay] Ann Arbor VA Med Ctr, Dept Internal Med, Ann Arbor, MI USA.
RP O'Grady, NP (reprint author), NIH, Dept Crit Care Med, Bethesda, MD 20892 USA.
EM nogrady@mail.cc.nih.gov
OI Randolph, Adrienne/0000-0002-3084-3071
FU NIH; Merck; Medscape; ASHP; IDSA; ASM; American College of Surgeons;
NQF; SHEA/CDC; SHEA/CDC, HHS; Trauma Shock Inflammation and Sepsis
Meeting (Munich); University of Minnesota; Angiotech; Astellas;
Theravance; Pfizer; Catheter Connections; Cubist; Cubist, Enzon;
Basilea; Eisai Pharmaceuticals, Discovery Laboratories; Molnlycke;
Cardinal Healthcare Foundation; Sanofi-Pasteur; 3M
FX E.P.D. Grant support through the NIH.; Potential conflicts of interest.
N.P. O'G. served as a board member for the ABIM Subspecialty Board for
Critical Care Medicine. M.A. is an employee of the Infusion Nurses
Society, Honoraria from 3M, Becton Dickinson, Smiths Medical. L.A.B. is
a consultant for Institute of Healthcare Improvement, Board membership
for Theradoc, Medline. Honoraria from APIC, Clorox. E.P.D. consulting
from Merck, Baxter, Ortho-McNeil, Targanta, Schering-Plough, Optimer,
Cadence, Cardinal, BDGeneOhm, WebEx, Cerebrio, and Tyco. Grant support
through the NIH. Payment for lecture from Merck. Payment for development
of educational presentation from Medscape. Travel and meeting expenses
paid for by ASHP, IDSA, ASM, American College of Surgeons, NQF,
SHEA/CDC, HHS, Trauma Shock Inflammation and Sepsis Meeting (Munich),
University of Minnesota. J.G. Honoria from Ethicon. S.O.H. provides
research support from Angiotech; Honoraria from Angiotech, Merck. L.A.M
provides research support from Astellas, Theravance, Pfizer; Consulting
for Ash Access, Cadence, Cor-Medix, Catheter Connections, Carefusion,
Sage, Bard, Teleflex; Payment for manuscript preparation from Catheter
Connections. I.I.R. provides research support from Cubist, Enzon, and
Basilea; Consulting for Clorox; Stock Equity or Options in Great Lakes
Pharmaceuticalsand Inventive Protocol; Speakers Bureau for Cook, Inc.;
Royalty income (patents owned by MD Anderson on which Dr. Raad in an
inventor: American Medical Systems, Cook, Inc., Cook urological,
Teleflex, TyRx, Medtronic, Biomet, Great Lakes Pharmaceuticals. A.R.
consulting income from Eisai Pharmaceuticals, Discovery Laboratories.
M.E.R. provides research support from Molnlycke, Cardinal Healthcare
Foundation, Sanofi-Pasteur, 3M, and Cubist; Consulting from Semprus;
Honorarium for lectures from 3M, Carefusion, Baxter and Becton
Dickinson. Previously served on Board of Directors for Society for
Healthcare Epidemiology of America. All other authors: no conflicts.
NR 371
TC 328
Z9 355
U1 7
U2 68
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-6553
EI 1527-3296
J9 AM J INFECT CONTROL
JI Am. J. Infect. Control
PD MAY
PY 2011
VL 39
IS 4
SU 1
BP S1
EP S34
DI 10.1016/j.ajic.2011.01.003
PG 34
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 752TI
UT WOS:000289716700001
PM 21511081
ER
PT J
AU Seyler, TH
Bernert, JT
AF Seyler, Tiffany H.
Bernert, John T.
TI Analysis of 4-aminobiphenyl in smoker's and nonsmoker's urine by tandem
mass spectrometry
SO BIOMARKERS
LA English
DT Article
DE Chemical carcinogenesis; tobacco science; mass spectroscopy
ID BLADDER-CANCER RISK; CARCINOGENIC AROMATIC-AMINES; ENVIRONMENTAL
TOBACCO-SMOKE; HEMOGLOBIN ADDUCT LEVELS; ADULT CIGARETTE SMOKERS;
MOLECULAR DOSIMETRY; LOS-ANGELES; EXPOSURE; BIOMARKERS; EPIDEMIOLOGY
AB The aromatic amine 4-aminobiphenyl (4-ABP) is present in tobacco smoke. In humans, it is also a known bladder carcinogen. We describe here a method for the quantification of total 4-ABP in urine using capillary gas chromatography/tandem mass spectrometry, with an effective detection limit in urine samples of approximately 0.87 pg/mL. We also examined the efficiency of chemical or enzymatic hydrolysis of urinary aromatic amine metabolites. Although we found acidic or basic hydrolysis effective, we found enzymatic hydrolysis (beta-glucuronidase with either Escherichia coli or Helix pomatia) ineffective. As part of this work, we also confirm the presence of N-acetyl-4-ABP and 4-ABP glucuronide in human urine samples from smokers. These metabolites have been reported in animal studies, but previously they have not been identified in human samples. These metabolites, however, were found to be unstable and thus infeasible for biomonitoring. The final validated urinary total 4-ABP assay was applied to the analysis of samples from smokers and nonsmokers, whose status was confirmed from cotinine EIA measurements. Among 41 confirmed nonsmokers, the geometric mean (95% CI) of 4-ABP concentration was 1.64 pg/mg creatinine (1.30-2.07). Conversely, in 89 smokers, the geometric mean of 4-ABP concentration was significantly greater, at 8.69 pg/mg creatinine (7.43-10.16), p < 0.001. Our results indicate that following tobacco smoke exposure, total urinary 4-ABP is a reliable biomarker for exposure to this carcinogen.
C1 [Seyler, Tiffany H.; Bernert, John T.] Ctr Dis Control & Prevent, Emergency Response & Air Toxicants Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
RP Seyler, TH (reprint author), Ctr Dis Control & Prevent, Emergency Response & Air Toxicants Branch, Div Sci Lab, Natl Ctr Environm Hlth, 4770 Buford Highway,Mailstop F-47, Atlanta, GA 30341 USA.
EM tvh2@cdc.gov
NR 30
TC 3
Z9 3
U1 1
U2 6
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1354-750X
J9 BIOMARKERS
JI Biomarkers
PD MAY
PY 2011
VL 16
IS 3
BP 212
EP 221
DI 10.3109/1354750X.2010.544755
PG 10
WC Biotechnology & Applied Microbiology; Toxicology
SC Biotechnology & Applied Microbiology; Toxicology
GA 753AZ
UT WOS:000289737900003
PM 21438718
ER
PT J
AU Janssens, ACJW
Ioannidis, JPA
Bedrosian, S
Boffetta, P
Dolan, SM
Dowling, N
Fortier, I
Freedman, AN
Grimshaw, JM
Gulcher, J
Gwinn, M
Hlatky, MA
Janes, H
Kraft, P
Melillo, S
O'Donnell, CJ
Pencina, MJ
Ransohoff, D
Schully, SD
Seminara, D
Winn, DM
Wright, CF
van Duijn, CM
Little, J
Khoury, MJ
AF Janssens, A. Cecile J. W.
Ioannidis, John P. A.
Bedrosian, Sara
Boffetta, Paolo
Dolan, Siobhan M.
Dowling, Nicole
Fortier, Isabel
Freedman, Andrew N.
Grimshaw, Jeremy M.
Gulcher, Jeffrey
Gwinn, Marta
Hlatky, Mark A.
Janes, Holly
Kraft, Peter
Melillo, Stephanie
O'Donnell, Christopher J.
Pencina, Michael J.
Ransohoff, David
Schully, Sheri D.
Seminara, Daniela
Winn, Deborah M.
Wright, Caroline F.
van Duijn, Cornelia M.
Little, Julian
Khoury, Muin J.
TI Strengthening the reporting of genetic risk prediction studies (GRIPS):
explanation and elaboration
SO EUROPEAN JOURNAL OF HUMAN GENETICS
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; HEART-DISEASE RISK; OPERATING CHARACTERISTIC
CURVE; TYPE-2 DIABETES RISK; RECLASSIFICATION MEASURES; MACULAR
DEGENERATION; DIAGNOSTIC-ACCURACY; CARDIOVASCULAR RISK;
CONTROLLED-TRIALS; PROSTATE-CANCER
AB The rapid and continuing progress in gene discovery for complex diseases is fueling interest in the potential application of genetic risk models for clinical and public health practice. The number of studies assessing the predictive ability is steadily increasing, but they vary widely in completeness of reporting and apparent quality. Transparent reporting of the strengths and weaknesses of these studies is important to facilitate the accumulation of evidence on genetic risk prediction. A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS), building on the principles established by previous reporting guidelines. These recommendations aim to enhance the transparency, quality and completeness of study reporting, and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct or analysis. European Journal of Human Genetics (2011) 19; doi:10.1038/ejhg.2011.27; published online 16 March 2011
C1 [Janssens, A. Cecile J. W.; van Duijn, Cornelia M.] Erasmus Univ, Med Ctr, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands.
[Ioannidis, John P. A.] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, GR-45110 Ioannina, Greece.
[Ioannidis, John P. A.] Fdn Res & Technol, Biomed Res Inst, Ioannina, Greece.
[Ioannidis, John P. A.] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA.
[Ioannidis, John P. A.] Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Tufts CTSI, Boston, MA USA.
[Ioannidis, John P. A.] Ctr Genet Epidemiol & Modeling, Boston, MA USA.
[Ioannidis, John P. A.] Stanford Univ, Sch Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA.
[Ioannidis, John P. A.; Bedrosian, Sara; Dowling, Nicole; Gwinn, Marta; Melillo, Stephanie; Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA USA.
[Boffetta, Paolo] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA.
[Boffetta, Paolo] Int Prevent Res Inst, Lyon, France.
[Dolan, Siobhan M.] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Bronx, NY 10467 USA.
[Fortier, Isabel] Publ Populat Project Genom P3G, Montreal, PQ, Canada.
[Freedman, Andrew N.; Schully, Sheri D.; Seminara, Daniela; Winn, Deborah M.] NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA.
[Grimshaw, Jeremy M.] Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada.
[Grimshaw, Jeremy M.] Univ Ottawa, Dept Med, Ottawa, ON, Canada.
[Gulcher, Jeffrey] deCODE Genet, Reykjavik, Iceland.
[Hlatky, Mark A.] Stanford Univ, Dept Hlth Res & Policy, Palo Alto, CA 94304 USA.
[Janes, Holly] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Inst, Seattle, WA 98104 USA.
[Janes, Holly] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA.
[Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[O'Donnell, Christopher J.] NHLBI, Framingham, MA USA.
[O'Donnell, Christopher J.] NHLBIs Framingham Heart Study, Framingham, MA USA.
[O'Donnell, Christopher J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Boston, MA USA.
[Pencina, Michael J.] Boston Univ, Dept Biostat, Boston, MA 02215 USA.
[Pencina, Michael J.] Harvard Clin Res Inst, Boston, MA USA.
[Ransohoff, David] Univ N Carolina, Sch Med, Chapel Hill, NC USA.
[Wright, Caroline F.] PHG Fdn, Cambridge, England.
[Little, Julian] Univ Ottawa, Dept Epidemiol & Community Med, Ottawa, ON, Canada.
RP Janssens, ACJW (reprint author), Erasmus Univ, Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM a.janssens@erasmusmc.nl
RI Ioannidis, John/G-9836-2011; janssens, cecile/L-1075-2015;
OI Janssens, A Cecile/0000-0002-6153-4976; Wright,
Caroline/0000-0003-2958-5076
FU National Heart, Lung and Blood Institute; National Cancer Institute,
National Institutes of Health; Donald W. Reynolds Foundation; Leducq
Foundation
FX Examples: 'This study was supported by grants from the National Heart,
Lung and Blood Institute and National Cancer Institute, National
Institutes of Health; the Donald W. Reynolds Foundation; and the Leducq
Foundation. Additional support for DNA extraction, reagents and data
analysis was provided by Roche Diagnostics and Amgen. Genotyping of the
9p21.3 variant was performed by Celera. The funding sources had no role
in the design, conduct, or reporting of this study or the decision to
submit the manuscript for publication'.56
NR 93
TC 2
Z9 2
U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1018-4813
J9 EUR J HUM GENET
JI Eur. J. Hum. Genet.
PD MAY
PY 2011
VL 19
IS 5
DI 10.1038/ejhg.2011.27
PG 18
WC Biochemistry & Molecular Biology; Genetics & Heredity
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 753OR
UT WOS:000289789500001
ER
PT J
AU Nierenberg, K
Hollenbeck, J
Fleming, LE
Stephan, W
Reich, A
Backer, LC
Currier, R
Kirkpatrick, B
AF Nierenberg, Kate
Hollenbeck, Julie
Fleming, Lora E.
Stephan, Wendy
Reich, Andrew
Backer, Lorraine C.
Currier, Robert
Kirkpatrick, Barbara
TI Frontiers in outreach and education: The Florida red tide experience
SO HARMFUL ALGAE
LA English
DT Article
DE Communication tools; Evaluation of outreach and education; Florida red
tide; Harmful algal blooms and public knowledge; Karenia brevis;
Outreach and education
AB To enhance information sharing and garner increased support from the public for scientific research, funding agencies now typically require that research groups receiving support convey their work to stakeholders. The National Institute of Environmental Health Sciences (NIEHS) funded Aerosolized Florida Red Tide P01 research group (Florida Red Tide Research Group) has employed a variety of outreach strategies to meet this requirement. Messages developed from this project began a decade ago and have evolved from basic print material (fliers and posters) to an interactive website, to the use of video and social networking technologies, such as Facebook and Twitter. The group was able to track dissemination of these information products; however, evaluation of their effectiveness presented much larger challenges. The primary lesson learned by the Florida Red Tide Research Group is that the best ways to reach specific stakeholders are to develop unique products or services to address specific stakeholders' needs, such as the Beach Conditions Reporting System. Based on the experience of the Group, the most productive messaging products result when scientific community engages potential stakeholders and outreach experts during the very initial phases of a project. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Nierenberg, Kate] Mote Marine Lab, Environm Hlth Program, Sarasota, FL 34236 USA.
[Hollenbeck, Julie; Fleming, Lora E.; Stephan, Wendy] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, NSF, Miami, FL 33149 USA.
[Hollenbeck, Julie; Fleming, Lora E.; Stephan, Wendy] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, NIEHS Oceans & Human Hlth Ctr, Miami, FL 33149 USA.
[Hollenbeck, Julie; Fleming, Lora E.; Stephan, Wendy] Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, NIEHS Marine & Freshwater Biomed Sci Ctr, Miami, FL 33149 USA.
[Reich, Andrew] Florida Dept Hlth, Tallahassee, FL 32399 USA.
[Backer, Lorraine C.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30329 USA.
[Kirkpatrick, Barbara] Miller Sch Med, Miami, FL 33149 USA.
RP Nierenberg, K (reprint author), Mote Marine Lab, Environm Hlth Program, 1600 Ken Thompson Pkwy, Sarasota, FL 34236 USA.
EM knierenberg@mote.org
FU DHHS NIH of the National Institute of Environmental Health Sciences [P01
ES 10594]; National Institute of Environmental Health Sciences (NIEHS)
Oceans and Human Health Center at the University of Miami Rosenstiel
School [NSF OCE0432368, NSF OCE0911373, NIEHS 1 P50 ES12736]; National
Science Foundation (NSF) [GEO-1009063]; National Institute of
Environmental Health Sciences (NIEHS) [1R21ES017413-01A2]; Centers for
Disease Control and Prevention and the Florida Department of Health
[U50/CCU423360-02]
FX This research was supported by the P01 ES 10594, DHHS NIH of the
National Institute of Environmental Health Sciences. Additional support
was received from the National Institute of Environmental Health
Sciences (NIEHS) Oceans and Human Health Center at the University of
Miami Rosenstiel School (NSF OCE0432368, NSF OCE0911373 and NIEHS 1 P50
ES12736), the National Science Foundation (NSF GEO-1009063), the
National Institute of Environmental Health Sciences (NIEHS
1R21ES017413-01A2) as well as by the Centers for Disease Control and
Prevention and the Florida Department of Health (Cooperative Agreement:
U50/CCU423360-02).[SS]
NR 12
TC 6
Z9 6
U1 5
U2 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1568-9883
J9 HARMFUL ALGAE
JI Harmful Algae
PD MAY
PY 2011
VL 10
IS 4
BP 374
EP 380
DI 10.1016/j.hal.2011.01.004
PG 7
WC Marine & Freshwater Biology
SC Marine & Freshwater Biology
GA 753WB
UT WOS:000289809600004
PM 21532966
ER
PT J
AU Law, HZ
Oraka, E
Mannino, DM
AF Law, Huay-Zong
Oraka, Emeka
Mannino, David M.
TI The Role of Income in Reducing Racial and Ethnic Disparities in
Emergency Room and Urgent Care Center Visits for Asthma-United States,
2001-2009
SO JOURNAL OF ASTHMA
LA English
DT Article
DE asthma; minority health; emergency medicine; income; socioeconomic
factors; disparities; race; ethnicity; emergency room; urgent care
centers
ID DEPARTMENT VISITS; MANAGEMENT PROGRAM; CHILDHOOD ASTHMA;
SEX-DIFFERENCES; URBAN CHILDREN; RISK-FACTORS; ADULTS; HEALTH;
HOSPITALIZATION; RACE/ETHNICITY
AB Objective. To examine racial/ethnic disparities and associated factors in asthma-related emergency room (ER) and urgent care center (UCC) visits among US adults and determine whether disparities vary across increasing income strata. Methods. We analyzed data from 238,678 adult respondents from the 2001 to 2009 National Health Interview Survey and calculated the weighted annual prevalence of an ER/UCC visit for persons with current asthma. We used logistic regression to calculate adjusted odds ratios (AORs) for asthma-related ER/UCC visits by race/ethnicity and income, adjusting for demographics, socioeconomic, and other health-related factors. Results. The average annual prevalence of asthma-related ER/UCC visits among adults with current asthma was highest for Puerto Ricans (24.8%, 95% confidence interval [CI]: 20.3-29.9) followed by non-Hispanic American Indian/Alaskan Natives (22.1%, 95% CI: 14.4-32.4), non-Hispanic blacks (20.4%, 95% CI: 18.5-22.4), other Hispanics (17.3%, 95% CI: 15.0-19.9), Asians (11.0%, 95% CI: 7.8-15.4), and non-Hispanic whites (10.1%, 95% CI: 9.4-10.9). Puerto Ricans (AOR: 2.01; 95% CI: 1.54-2.62), non-Hispanic blacks (AOR: 1.72; 95% CI: 1.46-2.03), and other Hispanics (AOR: 1.55; 95% CI: 1.25-1.92) with current asthma had significantly higher odds of an asthma-related ER/UCC visit than non-Hispanic whites. Lower socioeconomic status, obesity, and serious psychological distress were also associated with higher odds of asthma-related ER/UCC visits. Puerto Ricans with the lowest income (AOR: 3.52; 95% CI: 2.27-5.47), non-Hispanic American Indian/Alaskan Natives with the highest income (AOR: 5.71; 95% CI: 1.48-22.13), and non-Hispanic blacks in every income stratum had significantly higher odds of asthma-related ER/UCC visits compared to non-Hispanic whites in the highest income stratum. Conclusions. Racial/ethnic disparities in asthma-related ER/UCC visits persist after accounting for income and other socioeconomic factors. Further research is needed to identify modifiable risk factors directly associated to race/ethnicity to decrease the asthma burden on minority populations.
C1 [Law, Huay-Zong] Ctr Dis Control & Prevent, Air Pollut & Resp Hlth Program, Air Pollut & Resp Hlth Branch, Div Environm Hazards & Hlth Effects,Natl Ctr Envi, Chamblee, GA 30341 USA.
[Mannino, David M.] Univ Kentucky, Dept Prevent Med & Environm Hlth, Div Pulm & Crit Care Med, Coll Publ Hlth, Lexington, KY USA.
RP Law, HZ (reprint author), Ctr Dis Control & Prevent, Air Pollut & Resp Hlth Program, Air Pollut & Resp Hlth Branch, Div Environm Hazards & Hlth Effects,Natl Ctr Envi, 4770 Buford Highway,Mailstop F-58, Chamblee, GA 30341 USA.
EM lawh@wusm.wustl.edu
OI Mannino, David/0000-0003-3646-7828
FU Centers for Disease Control and Prevention (CDC); CDC Foundation through
Pfizer
FX This work was supported by the Centers for Disease Control and
Prevention (CDC). All authors attest that there are no conflicts of
interest related to the submission of this manuscript. Mr. H.-Z. Law
participated in a research fellowship at CDC sponsored by the CDC
Foundation through a grant funded by Pfizer. Mr. E. Oraka is an Oak
Ridge Institute for Science and Education Fellow at CDC. The findings
and conclusions in this report are those of the authors and do not
necessarily represent the views of the Centers for Disease Control and
Prevention.
NR 47
TC 12
Z9 12
U1 0
U2 9
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 0277-0903
J9 J ASTHMA
JI J. Asthma
PD MAY
PY 2011
VL 48
IS 4
BP 405
EP 413
DI 10.3109/02770903.2011.565849
PG 9
WC Allergy; Respiratory System
SC Allergy; Respiratory System
GA 752IP
UT WOS:000289685100015
PM 21504353
ER
PT J
AU Berg, CJ
Callaghan, WM
Henderson, Z
Syverson, C
AF Berg, Cynthia J.
Callaghan, William M.
Henderson, Zsakeba
Syverson, Carla
TI Pregnancy-Related Mortality in the United States, 1998 to 2005 Reply
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Letter
C1 [Berg, Cynthia J.; Callaghan, William M.; Henderson, Zsakeba] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA.
[Syverson, Carla] Empowered Global Solut, Englewood, CO USA.
RP Berg, CJ (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA.
NR 2
TC 11
Z9 12
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD MAY
PY 2011
VL 117
IS 5
BP 1230
EP 1230
DI 10.1097/AOG.0b013e31821769ed
PG 1
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 753KF
UT WOS:000289771000039
ER
PT J
AU Portier, CJ
AF Portier, Christopher J.
TI Comprehensive Environmental Public Health
SO PUBLIC HEALTH REPORTS
LA English
DT Editorial Material
C1 [Portier, Christopher J.] Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, Atlanta, GA 30341 USA.
[Portier, Christopher J.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
RP Portier, CJ (reprint author), Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, 4770 Buford Hwy,MS F61, Atlanta, GA 30341 USA.
EM cip7@cdc.gov
RI Portier, Christopher/A-3160-2010
OI Portier, Christopher/0000-0002-0954-0279
NR 2
TC 0
Z9 0
U1 0
U2 2
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD MAY-JUN
PY 2011
VL 126
SU 1
BP 3
EP 6
PG 4
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 752AK
UT WOS:000289659700002
PM 21563706
ER
PT J
AU Ruckart, PZ
Moore, C
Burgin, D
Byrne, MK
AF Ruckart, Perri Zeitz
Moore, Cory
Burgin, Deborah
Byrne, Maggie Kelly
TI The 2009 National Environmental Public Health Conference: One Model for
Planning Green and Healthy Conferences
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID OBESITY
AB The Centers for Disease Control and Prevention's National Center for Environmental Health and the Agency for Toxic Substances and Disease Registry committed to making their 2009 National Environmental Public Health Conference a model for green and healthy conferences. The conference included increased opportunities for physical activity, both as part of conference events and for transportation to the conference. In addition, conference meals were healthy and sustainably sourced. The conference also implemented intuitive, accessible recycling; online scheduling and evaluation to minimize hard-copy materials; and the purchase of carbon offsets to reduce the unwanted environmental impact of the conference. Public health professionals have an opportunity and obligation to support healthy behaviors at their events and to serve as leaders in this area. Facilitating healthy and sustainable choices is in alignment with goals for both public health and broader social issues-such as environmental quality-that have a direct bearing on public health.
C1 [Ruckart, Perri Zeitz; Moore, Cory; Burgin, Deborah] Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, Atlanta, GA 30341 USA.
[Ruckart, Perri Zeitz; Moore, Cory; Burgin, Deborah] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
RP Ruckart, PZ (reprint author), Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, 4770 Buford Hwy,MS F57, Atlanta, GA 30341 USA.
EM pruckart@cdc.gov
NR 15
TC 0
Z9 0
U1 0
U2 4
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD MAY-JUN
PY 2011
VL 126
SU 1
BP 58
EP 63
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 752AK
UT WOS:000289659700009
PM 21563713
ER
PT J
AU King, ME
Damon, SA
AF King, Michael E.
Damon, Scott A.
TI Attitudes about Carbon Monoxide Safety in the United States: Results
from the 2005 and 2006 HealthStyles Survey
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID PLANNED BEHAVIOR; ICE STORM; PREVENTION; HOUSEHOLDS; OUTBREAK
AB Objectives. We sought to identify attitudes and behaviors related to carbon monoxide (CO) safety that can be targeted with public health prevention strategies in the U.S.
Methods. The Centers for Disease Control and Prevention added questions about (1) proper placement of gas-powered generators, (2) maintenance of fuel-burning appliances, and (3) use of CO detectors to the 2005 and 2006 Health Styles national health marketing surveys.
Results. In 2005, 63.3% of Health Styles respondents agreed with or were uncertain about the incorrect statement, "It is safe to run a generator in a garage as long as the door is open," while 43.1% agreed with or were uncertain about the incorrect statement, "It is safe to run a generator in the basement." Most of the 2006 respondents (63.5%) agreed that it is important to have their furnace inspected annually. However, fewer than half of the 2006 respondents (42.0%)-most of whom were homeowners-reported owning a CO detector.
Conclusions. A large proportion of adults in the U.S. reported attitudes and behaviors that may place them at increased risk for unintentional, non-firerelated CO poisoning, suggesting that current safety messages may not be reaching much of the public. Prevention messages should continue to promote proper generator placement, maintenance of fuel-burning appliances, and use of CO detectors. Development of a comprehensive national strategy for CO surveillance and communication may help identify populations at increased risk and prevent future poisonings.
C1 [King, Michael E.] Ctr Dis Control & Prevent, Air Pollut & Resp Hlth Branch, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
RP King, ME (reprint author), Ctr Dis Control & Prevent, Air Pollut & Resp Hlth Branch, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, 4770 Buford Hwy,MS F-58, Atlanta, GA 30341 USA.
EM nzk7@cdc.gov
NR 38
TC 3
Z9 3
U1 1
U2 3
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD MAY-JUN
PY 2011
VL 126
SU 1
BP 100
EP 107
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 752AK
UT WOS:000289659700013
PM 21563717
ER
PT J
AU Lutterloh, EC
Iqbal, S
Clower, JH
Spiller, HA
Riggs, MA
Sugg, TJ
Humbaugh, KE
Cadwell, BL
Thoroughman, DA
AF Lutterloh, Emily C.
Iqbal, Shahed
Clower, Jacquelyn H.
Spiller, Henry A.
Riggs, Margaret A.
Sugg, Tennis J.
Humbaugh, Kraig E.
Cadwell, Betsy L.
Thoroughman, Douglas A.
TI Carbon Monoxide Poisoning After an Ice Storm in Kentucky, 2009
SO PUBLIC HEALTH REPORTS
LA English
DT Article
AB Objectives. Carbon monoxide (CO) poisoning is a leading cause of morbidity and mortality during natural disasters. On January 26-27, 2009, a severe ice storm occurred in Kentucky, causing widespread, extended power outages and disrupting transportation and communications. After the storm, CO poisonings were reported throughout the state. The objectives of this investigation were to determine the extent of the problem, identify sources of CO poisoning, characterize cases, make recommendations to reduce morbidity and mortality, and develop prevention strategies.
Methods. We obtained data from the Kentucky Regional Poison Center (KRPC), hyperbaric oxygen treatment (HBOT) facilities, and coroners. Additionally, the Kentucky Department for Public Health provided statewide emergency department (ED) and hospitalization data.
Results. During the two weeks after the storm, KRPC identified 144 cases of CO poisoning; exposure sources included kerosene heaters, generators, and propane heaters. Hospitals reported 202 ED visits and 26 admissions. Twenty-eight people received HBOT. Ten deaths were attributed to CO poisoning, eight of which were related to inappropriate generator location. Higher rates of CO poisoning were reported in areas with the most ice accumulation.
Conclusions. Although CO poisonings are preventable, they continue to occur in postdisaster situations. Recommendations include encouraging use of CO alarms, exploring use of engineering controls on generators to decrease CO exposure, providing specific information regarding safe use and placement of CO-producing devices, and using multiple communication methods to reach people without electricity.
C1 [Iqbal, Shahed] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Air Pollut & Resp Hlth Branch, Atlanta, GA 30341 USA.
[Lutterloh, Emily C.; Iqbal, Shahed; Cadwell, Betsy L.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Sci Educ & Profess Dev Program Off, Atlanta, GA 30341 USA.
[Lutterloh, Emily C.; Riggs, Margaret A.; Sugg, Tennis J.; Humbaugh, Kraig E.; Thoroughman, Douglas A.] Kentucky Dept Publ Hlth, Frankfort, KY USA.
[Spiller, Henry A.] Kentucky Reg Poison Ctr, Louisville, KY USA.
[Riggs, Margaret A.; Thoroughman, Douglas A.] Ctr Dis Control & Prevent, Off Publ Hlth Preparedness & Response, Atlanta, GA 30341 USA.
RP Iqbal, S (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Air Pollut & Resp Hlth Branch, 4770 Buford Hwy NE,MS F-58, Atlanta, GA 30341 USA.
EM SIqbal@cdc.gov
NR 22
TC 12
Z9 12
U1 0
U2 2
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD MAY-JUN
PY 2011
VL 126
SU 1
BP 108
EP 115
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 752AK
UT WOS:000289659700014
PM 21563718
ER
PT J
AU Melnikova, N
Welles, WL
Wilburn, RE
Rice, N
Wu, J
Stanbury, M
AF Melnikova, Natalia
Welles, Wanda Lizak
Wilburn, Rebecca E.
Rice, Nancy
Wu, Jennifer
Stanbury, Martha
TI Hazards of Illicit Methamphetamine Production and Efforts at Reduction:
Data from the Hazardous Substances Emergency Events Surveillance System
SO PUBLIC HEALTH REPORTS
LA English
DT Article
AB Objectives. Methamphetamine (meth) is a highly addictive drug of abuse that can easily be made in small illegal laboratories from household chemicals that are highly toxic and dangerous. Meth labs have been found in locations such as homes, outbuildings, motels, and cars. Its production endangers the "cook," neighbors, responders, and the environment. This article describes surveillance data used to examine the emergence and public health impacts of illicit clandestine meth labs, as well as two states' efforts to thwart lab operations and prevent responder injuries.
Methods. We analyzed data collected from 2001 to 2008 by 18 states participating in the Agency for Toxic Substances and Disease Registry's Hazardous Substances Emergency Events Surveillance (HSEES) Program to examine the occurrence and public health impacts of clandestine meth production.
Results. HSEES data indicate that the majority of clandestine meth lab events occurred in residential areas. About 15% of meth lab events required evacuation. Nearly one-fourth of these events resulted in injuries, with 902 reported victims. Most victims (61%) were official responders, and one-third were members of the general public. Since 2004, with the implementation of local and federal laws and prevention activities, the number of meth lab events has declined. Increased education and training of first responders has led to decreased injuries among police officers, firefighters, and emergency medical personnel.
Conclusions. HSEES data provided a good data source for monitoring the emergence of domestic clandestine meth production, the associated public health effects, and the results of state and federal efforts to promote actions to address the problem.
C1 [Melnikova, Natalia; Wu, Jennifer] Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, Div Hlth Studies, Atlanta, GA 30341 USA.
[Welles, Wanda Lizak; Wilburn, Rebecca E.] Natl Tox Subst Incidents Program, Bur Tox Subst Assessment, Div Environm Hlth Assessment, Ctr Environm Hlth,New York State Dept Hlth, Troy, NY USA.
[Rice, Nancy] Hazardous Subst Emergency Events Surveillance Pro, Div Environm Hlth, Minnesota Dept Hlth, St Paul, MN USA.
[Stanbury, Martha] Michigan Dept Community Hlth, Div Environm Hlth, Lansing, MI USA.
RP Melnikova, N (reprint author), Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, Div Hlth Studies, 4770 Buford Hwy,MS F-57, Atlanta, GA 30341 USA.
EM nbm6@cdc.gov
NR 18
TC 6
Z9 7
U1 1
U2 9
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD MAY-JUN
PY 2011
VL 126
SU 1
BP 116
EP 123
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 752AK
UT WOS:000289659700015
PM 21563719
ER
PT J
AU Brown, MJ
Jacobs, DE
AF Brown, Mary Jean
Jacobs, David E.
TI Residential Light and Risk for Depression and Falls: Results from the
LARES Study of Eight European Cities
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID SEASONAL AFFECTIVE-DISORDER; NONSEASONAL DEPRESSION; BRIGHT LIGHT;
THERAPY; EFFICACY; COMMUNITY; MELATONIN; PEOPLE
AB Objectives. We examined the relationship between self-reported inadequate residential natural light and risk for depression or falls among adults aged 18 years or older.
Methods. Generalized estimating equations were used to calculate the odds of depression or falls in participants with self-reported inadequate natural residential light vs. those reporting adequate light (n=6, 017) using data from the World Health Organization's Large Analysis and Review of European Housing and Health Survey, a large cross-sectional study of housing and health in representative populations from eight European cities.
Results. Participants reporting inadequate natural light in their dwellings were 1.4 times (95% confidence interval [Cl] 1.2, 1.7) as likely to report depression and 1.5 times (95% Cl 1.2, 1.9) as likely to report a fall compared with those satisfied with their dwelling's light. After adjustment for major confounders, the likelihood of depression changed slightly, while the likelihood of a fall increased to 2.5 (95% Cl 1.5, 4.2).
Conclusion. Self-reported inadequate light in housing is independently associated with depression and falls. Increasing light in housing, a relatively inexpensive intervention, may improve two distinct health conditions.
C1 [Brown, Mary Jean] Ctr Dis Control & Prevent, Div Emergency & Environm Hlth Serv, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA.
[Jacobs, David E.] Natl Ctr Healthy Housing, Columbia, MD USA.
RP Brown, MJ (reprint author), Ctr Dis Control & Prevent, Div Emergency & Environm Hlth Serv, Natl Ctr Environm Hlth, 4770 Buford Hwy NE,MS F-46, Atlanta, GA 30341 USA.
EM mjb5@cdc.gov
FU German Federal Ministry of Health
FX The World Health Organization (WHO) coordinated the Large Analysis and
Review of European Housing and Health Status study with funding from the
German Federal Ministry of Health. Staff time for the authors' work was
provided by the U.S. Centers for Disease Control and Prevention. All
applicable European requirements regarding human subjects protection
were met by WHO.
NR 29
TC 4
Z9 6
U1 1
U2 4
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD MAY-JUN
PY 2011
VL 126
SU 1
BP 131
EP 140
PG 10
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 752AK
UT WOS:000289659700017
PM 21563721
ER
PT J
AU Lovegrove, MC
Shehab, N
Hales, CM
Poneleit, K
Crane, E
Budnitz, DS
AF Lovegrove, Maribeth C.
Shehab, Nadine
Hales, Craig M.
Poneleit, Kathy
Crane, Elizabeth
Budnitz, Daniel S.
TI Emergency Department Visits for Antiviral Adverse Events During the 2009
H1N1 Influenza Pandemic
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID UNITED-STATES
AB The 2009 pandemic influenza A (H1N1) outbreak was associated with an increased use of antiviral agents and highlighted the role of population-based monitoring for related adverse drug events (ADEs). An ongoing, nationally representative emergency department-based surveillance system was used to identify and characterize ADEs during the pandemic. Active surveillance for ADEs successfully provided timely, population-based data during the pandemic. Increases in antiviral ADEs paralleled increases in prescribing. Type and severity of ADEs were similar across all seasons.
C1 [Lovegrove, Maribeth C.; Shehab, Nadine; Budnitz, Daniel S.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
[Hales, Craig M.] Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA.
[Poneleit, Kathy; Crane, Elizabeth] Substance Abuse & Mental Hlth Serv Adm, Ctr Behav Hlth Stat & Qual, Div Facil Surveys, Drug Abuse Warning Network, Rockville, MD USA.
RP Budnitz, DS (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Healthcare Qual Promot, 1600 Clifton Rd NE,MS A-24, Atlanta, GA 30333 USA.
EM dbudnitz@cdc.gov
NR 17
TC 4
Z9 4
U1 0
U2 0
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD MAY-JUN
PY 2011
VL 126
IS 3
BP 312
EP 317
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 752AJ
UT WOS:000289659600003
PM 21553658
ER
PT J
AU Alfonsi, GA
Datta, SD
Mickiewicz, T
Koutsky, LA
Ghanem, K
Hagensee, M
Kerndt, P
Hsu, K
Weinstock, H
Shlay, JC
AF Alfonsi, Grace A.
Datta, S. Deblina
Mickiewicz, Theresa
Koutsky, Laura A.
Ghanem, Khalil
Hagensee, Michael
Kerndt, Peter
Hsu, Katherine
Weinstock, Hillard
Shlay, Judith C.
TI Prevalence of High-Risk HPV Types and Abnormal Cervical Cytology in
American Indian/Alaska Native Women, 2003-2005
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID HUMAN-PAPILLOMAVIRUS INFECTION; EARLY-DETECTION PROGRAM; ALASKA-NATIVES;
UNITED-STATES; CANCER INCIDENCE; RACIAL MISCLASSIFICATION; QUADRIVALENT
VACCINE; NATIONAL BREAST; INDIANS; SURVEILLANCE
AB Objectives. We described prevalence estimates of high-risk human papillomavirus (HR-HPV), HPV types 16 and 18, and abnormal Papanicolaou (Pap) smear tests among American Indian/Alaska Native (Al/AN) women compared with women of other races/ethnicities.
Methods. A total of 9,706 women presenting for cervical screening in a sentinel network of 26 clinics (sexually transmitted disease, family planning, and primary care) received Pap smears and HR-HPV type-specific testing. We compared characteristics of 291 women self-identified as Al/AN with other racial/ethnic minority groups.
Results. In our population, Al/AN and non-Hispanic white (NHW) women had similar age- and clinic-adjusted prevalences of HR-HPV (29.1%, 95% confidence interval (CI] 23.9, 34.3 for AI/AN women vs. 25.8%, 95% CI 24.4, 27.2 for NHW women), HPV 16 and 18 (6.7%, 95% CI 3.9, 9.6 for AI/AN women vs. 8.8%, 95% CI 7.9, 9.7 for NHW women), and abnormal Pap smear test results (16%, 95% CI 11.7, 20.3 for AI/AN women vs. 14.9%, 95% CI 13.7, 16.0 for NHW women). Al/AN women had a higher prevalence of HR-HPV than Hispanic women, and a similar prevalence of HPV 16 and 18 as compared with Hispanic and African American women.
Conclusions. We could not demonstrate differences in the prevalence of HR-HPV, HPV 16 and 18, or abnormal Pap smear test results between Al/AN and NHW women. This finding should improve confidence in the benefit of HPV vaccine and Pap smear screening in the Al/AN population as an effective strategy to reduce rates of cervical cancer.
C1 [Alfonsi, Grace A.; Mickiewicz, Theresa; Shlay, Judith C.] Denver Publ Hlth, Denver Hlth Med Ctr, Denver, CO 80204 USA.
[Datta, S. Deblina; Weinstock, Hillard] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA.
[Koutsky, Laura A.] Univ Washington, Seattle, WA 98195 USA.
[Ghanem, Khalil] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
[Hagensee, Michael] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA.
[Kerndt, Peter] Los Angeles Cty Dept Hlth, STD Program, Los Angeles, CA USA.
[Hsu, Katherine] Massachusetts Dept Publ Hlth, Boston, MA USA.
RP Alfonsi, GA (reprint author), Denver Publ Hlth, Denver Hlth Med Ctr, 301 W 6th Ave,MC0151, Denver, CO 80204 USA.
EM Grace.Alfonsi@dhha.org
NR 36
TC 3
Z9 4
U1 0
U2 1
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD MAY-JUN
PY 2011
VL 126
IS 3
BP 330
EP 337
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 752AJ
UT WOS:000289659600005
PM 21553660
ER
PT J
AU Gilboa, SM
AF Gilboa, S. M.
TI But What Else Could There Be? Additional Methodological Issues to
Consider in the Observational Study of SSRIs during Pregnancy
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Gilboa, S. M.] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2011
VL 91
IS 5
SI SI
BP 313
EP 313
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 762QQ
UT WOS:000290494900013
ER
PT J
AU Newsome, K
Williams, J
Rasmussen, SA
Callaghan, W
Mcintyre, A
Hill, H
Way, S
Honein, M
Jamieson, D
Zotti, M
Finelli, L
AF Newsome, K.
Williams, J.
Rasmussen, S. A.
Callaghan, W.
Mcintyre, A.
Hill, H.
Way, S.
Honein, M.
Jamieson, D.
Zotti, M.
Finelli, L.
TI Infant Outcomes among Critically Ill Pregnant Women with
Laboratory-Confirmed Influenza during the 2009 H1N1 Influenza Pandemic
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Newsome, K.; Way, S.] SciMetrika LLC, Res Triangle Pk, NC USA.
[Williams, J.; Rasmussen, S. A.; Honein, M.] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA.
[Callaghan, W.; Jamieson, D.; Zotti, M.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA.
[Mcintyre, A.; Finelli, L.] Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA.
[Hill, H.] RTI Int, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2011
VL 91
IS 5
SI SI
BP 392
EP 392
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 762QQ
UT WOS:000290494900158
ER
PT J
AU Potter, P
AF Potter, Polyxeni
TI And therefore I have sailed the seas and come To the holy city of
Byzantium
SO EMERGING INFECTIOUS DISEASES
LA English
DT Editorial Material
C1 Ctr Dis Control & Prevent, Atlanta, GA 30333 USA.
RP Potter, P (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D61, Atlanta, GA 30333 USA.
EM PMP1@cdc.gov
NR 4
TC 0
Z9 0
U1 0
U2 1
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD MAY
PY 2011
VL 17
IS 5
BP 958
EP 959
DI 10.3201/eid1705.AC1705
PG 2
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 760AB
UT WOS:000290291900052
PM 21529432
ER
PT J
AU Kumar, GS
Saenger, M
Varma, S
Burleson, M
Kohrt, B
Cantey, P
AF Kumar, Gayathri Suresh
Saenger, Michael
Varma, Selina
Burleson, Molly
Kohrt, Brandon
Cantey, Paul
TI THE BURDEN OF CHRONIC DISEASE AMONG THE BHUTANESE REFUGEE POPULATION AT
A US URBAN CLINIC
SO JOURNAL OF GENERAL INTERNAL MEDICINE
LA English
DT Meeting Abstract
C1 [Kumar, Gayathri Suresh; Saenger, Michael; Varma, Selina; Burleson, Molly; Kohrt, Brandon] Emory Univ, Atlanta, GA 30322 USA.
[Cantey, Paul] Ctr Dis Control & Prevent, Atlanta, GA USA.
NR 0
TC 0
Z9 0
U1 3
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0884-8734
EI 1525-1497
J9 J GEN INTERN MED
JI J. Gen. Intern. Med.
PD MAY
PY 2011
VL 26
SU 1
BP S131
EP S132
PG 2
WC Health Care Sciences & Services; Medicine, General & Internal
SC Health Care Sciences & Services; General & Internal Medicine
GA V30JQ
UT WOS:000208812701005
ER
PT J
AU Simmons, EM
Brown, MJ
Sly, K
Ma, M
Sutton, MY
McLellan-Lemal, E
AF Simmons, Emma M.
Brown, Monique J.
Sly, Kaye
Ma, Mindy
Sutton, Madeline Y.
McLellan-Lemal, Eleanor
TI Barriers and Facilitators to HIV Testing in Primary Care Among Health
Care Providers
SO JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
LA English
DT Article
DE stigma; risk assessment; health disparities; HIV/AIDS
ID HUMAN-IMMUNODEFICIENCY-VIRUS; UNITED-STATES; ROUTINE; INFECTION;
SETTINGS
AB Purpose: Human immunodeficiency virus (HIV) is a preventable disease that can have improved outcomes with early diagnosis and treatment. The CDC recommends that HIV testing be incorporated into clinical settings as part of routine medical care.
Methods: Individual, open-ended interviews were conducted with primary care providers and administrators to obtain their views regarding the meaning of routine HIV testing and the barriers and facilitators to implementing routine HIV testing in their respective practices.
Results: Most respondents supported routine HIV testing, although their definitions of routine varied. Barriers for providers included time and financial constraints to appropriately conduct HIV counseling and testing and inadequate HIV education and training. Facilitators for implementing routine HIV testing included patients' feelings of empowerment and reduced HIV stigma.
Conclusions: The implementation of routine HIV testing in primary care practices appears to be an acceptable public health intervention. Next steps should include efforts to standardize the definition of routine HIV testing and working with primary care settings to better understand and reduce barriers to routine testing.
C1 [Simmons, Emma M.] Brown Univ, Dept Family Med, Alpert Med Sch, Providence, RI 02912 USA.
[Brown, Monique J.] Brown Univ, Program Publ Hlth, Providence, RI 02912 USA.
[Sly, Kaye] Jackson State Univ, Jackson, MS USA.
[Ma, Mindy] Nova SE Univ, Ft Lauderdale, FL 33314 USA.
[Sutton, Madeline Y.; McLellan-Lemal, Eleanor] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA.
RP Simmons, EM (reprint author), Brown Univ, Alpert Med Sch, Dept Family Med, 111 Brewster St, Pawtucket, RI 02860 USA.
EM emma_simmons@mhri.org
FU Centers for Disease Control and Prevention (CDC); Minority HIV/AIDS
Research Initiative [U65/CCU124165]
FX This research was funded by the Centers for Disease Control and
Prevention (CDC), Minority HIV/AIDS Research Initiative cooperative
agreement U65/CCU124165.
NR 28
TC 5
Z9 5
U1 0
U2 2
PU NATL MED ASSOC
PI WASHINGON
PA 1012 10TH ST, N W, WASHINGON, DC 20001 USA
SN 0027-9684
J9 J NATL MED ASSOC
JI J. Natl. Med. Assoc.
PD MAY
PY 2011
VL 103
IS 5
BP 432
EP 438
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA 784QS
UT WOS:000292173900007
PM 21809793
ER
PT J
AU Donado, C
Duperly, J
Lobelo, F
Ramirez, A
Montoya, E
Cano, N
Avila, A
Sarmiento, OL
Pratt, M
AF Donado, Carolina
Duperly, John
Lobelo, Felipe
Ramirez, Andrea
Montoya, Eliana
Cano, Natalia
Avila, Andrea
Sarmiento, Olga L.
Pratt, Michael
TI Prevalence of Risk Factors for Recreational Race-Associated
Cardiovascular Events Among Runners in Bogota City
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
C1 [Donado, Carolina; Duperly, John; Ramirez, Andrea; Montoya, Eliana; Cano, Natalia; Sarmiento, Olga L.] Univ Los Andes, Bogota, Colombia.
[Lobelo, Felipe; Pratt, Michael] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Avila, Andrea] Univ Nacl Colombia, Bogota, Colombia.
EM g-donado@uniandes.edu.co
NR 0
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2011
VL 43
IS 5
SU 1
MA 1551
BP 345
EP 346
PG 3
WC Sport Sciences
SC Sport Sciences
GA V34IG
UT WOS:000209079501307
ER
PT J
AU Watson, KB
Fulton, JE
AF Watson, Kathleen B.
Fulton, Janet E.
TI Physical Activity Patterns among Youth in the United States
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
C1 [Watson, Kathleen B.] Baylor Coll Med, Houston, TX 77030 USA.
[Fulton, Janet E.] Ctr Dis Control & Prevent, Atlanta, GA USA.
EM kwatson@bcm.edu
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2011
VL 43
IS 5
SU 1
MA 1680
BP 391
EP 391
PG 1
WC Sport Sciences
SC Sport Sciences
GA V34IG
UT WOS:000209079501436
ER
PT J
AU Lobelo, F
Donado, C
Duperly, J
Sarmiento, OL
Pratt, M
Frank, E
AF Lobelo, Felipe
Donado, Carolina
Duperly, John
Sarmiento, Olga L.
Pratt, Michael
Frank, Erica
TI Freshman Medical Students' Health and Fitness Levels Influence Their
Attitudes Regarding Future Physical Activity Counseling
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
C1 [Lobelo, Felipe; Pratt, Michael] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Donado, Carolina; Duperly, John; Sarmiento, Olga L.] Univ Los Andes, Bogota, Colombia.
[Frank, Erica] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
EM rlobelo@cdc.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2011
VL 43
IS 5
SU 1
MA 2107
BP 546
EP 546
PG 1
WC Sport Sciences
SC Sport Sciences
GA V34IG
UT WOS:000209079502219
ER
PT J
AU Hootman, JM
Carroll, DD
McKinght-Leily, L
Allen, KD
AF Hootman, Jennifer M.
Carroll, Dianna D.
McKinght-Leily, Lela
Allen, Kelli D.
TI Physical Activity and Frequent Sleep Insufficiency Among US Adults with
Arthritis
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
C1 [Hootman, Jennifer M.] Ctr Dis Control & Prevent, Kennesaw, GA USA.
[Carroll, Dianna D.; McKinght-Leily, Lela] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Allen, Kelli D.] Durham VA Med Ctr, Durham, NC USA.
EM jhootman@cdc.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2011
VL 43
IS 5
SU 1
MA 2187
BP 576
EP 576
PG 1
WC Sport Sciences
SC Sport Sciences
GA V34IG
UT WOS:000209079502299
ER
PT J
AU Boehmer, TK
AF Boehmer, Tegan K.
TI Summary of CDC Workshop on Physical Activity Guidelines and Air
Pollution Exposure
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
C1 [Boehmer, Tegan K.] Ctr Dis Control & Prevent, Atlanta, GA USA.
EM tboehmer@cdc.gov
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2011
VL 43
IS 5
SU 1
MA 2191
BP 577
EP 577
PG 1
WC Sport Sciences
SC Sport Sciences
GA V34IG
UT WOS:000209079502303
ER
PT J
AU Soares, J
Brown, DR
Lankford, T
Wallace, J
Hopkins, D
AF Soares, Jesus
Brown, David R.
Lankford, Tina
Wallace, Jana
Hopkins, David
TI Stand Alone Mass Media Campaigns to Increase Physical Activity: The
Community Guide Task Force Conclusion
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
C1 [Soares, Jesus; Brown, David R.; Lankford, Tina; Wallace, Jana; Hopkins, David] CDC, Atlanta, GA 30333 USA.
EM jsoares@cdc.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2011
VL 43
IS 5
SU 1
MA 2529
BP 693
EP 694
PG 2
WC Sport Sciences
SC Sport Sciences
GA V34IG
UT WOS:000209079502630
ER
PT J
AU Mattran, K
Harris, CD
Jernigan, J
Fulton, JE
AF Mattran, Kelly
Harris, Carmen D.
Jernigan, Jan
Fulton, Janet E.
TI Evaluating the Awareness, Access, and Use of The State Indicator Report
On Physical Activity, 2010
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
C1 [Mattran, Kelly] James Madison Univ, Harrisonburg, VA 22807 USA.
[Harris, Carmen D.; Jernigan, Jan; Fulton, Janet E.] Ctr Dis Control & Prevent, Atlanta, GA USA.
EM mattraka@jmu.edu
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2011
VL 43
IS 5
SU 1
MA 2594
BP 715
EP 716
PG 2
WC Sport Sciences
SC Sport Sciences
GA V34IG
UT WOS:000209079503063
ER
PT J
AU Carroll, DD
Cunningham, M
Carlson, SA
Fulton, JE
AF Carroll, Dianna D.
Cunningham, Melissa
Carlson, Susan A.
Fulton, Janet E.
TI Awareness and Knowledge of the 2008 Physical Activity Guidelines for
Americans
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
C1 [Carroll, Dianna D.; Cunningham, Melissa; Carlson, Susan A.; Fulton, Janet E.] Ctr Dis Control & Prevent, Atlanta, GA USA.
EM feu9@cdc.gov
NR 0
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2011
VL 43
IS 5
SU 1
MA 2607
BP 720
EP 720
PG 1
WC Sport Sciences
SC Sport Sciences
GA V34IG
UT WOS:000209079503076
ER
PT J
AU Song, M
Carroll, DD
Fulton, JE
AF Song, MinKyoung
Carroll, Dianna D.
Fulton, Janet E.
TI Muscle-strengthening In U.s. Youth: Findings From Nhanes 1999-2006
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
C1 [Song, MinKyoung; Carroll, Dianna D.; Fulton, Janet E.] Ctr Dis Control & Prevent, Atlanta, GA USA.
EM MSong@cdc.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2011
VL 43
IS 5
SU 1
MA 2610
BP 721
EP 721
PG 1
WC Sport Sciences
SC Sport Sciences
GA V34IG
UT WOS:000209079503079
ER
PT J
AU Harris, CD
Purcell, NC
Fulton, JE
AF Harris, Carmen D.
Purcell, Nora C.
Fulton, Janet E.
TI Access To Parks In The United States
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Meeting Abstract
C1 [Harris, Carmen D.; Fulton, Janet E.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Purcell, Nora C.] Agcy Tox Subst & Dis Registry, Atlanta, GA USA.
EM charris2@cdc.gov
NR 0
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2011
VL 43
IS 5
SU 1
MA 2616
BP 723
EP 723
PG 1
WC Sport Sciences
SC Sport Sciences
GA V34IG
UT WOS:000209079503085
ER
PT J
AU Aradaib, IE
Erickson, BR
Karsany, MS
Khristova, ML
Elageb, RM
Mohamed, MEH
Nichol, ST
AF Aradaib, Imadeldin E.
Erickson, Bobbie R.
Karsany, Mubarak S.
Khristova, Marina L.
Elageb, Rehab M.
Mohamed, Mohamed E. H.
Nichol, Stuart T.
TI Multiple Crimean-Congo Hemorrhagic Fever Virus Strains Are Associated
with Disease Outbreaks in Sudan, 2008-2009
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID RNA SEGMENTS; SAUDI-ARABIA; PROVINCE; INFECTION; PAKISTAN
AB Background: Crimean-Congo hemorrhagic fever (CCHF) activity has recently been detected in the Kordufan region of Sudan. Since 2008, several sporadic cases and nosocomial outbreaks associated with high case-fatality have been reported in villages and rural hospitals in the region.
Principal Findings: In the present study, we describe a cluster of cases occurring in June 2009 in Dunkop village, Abyei District, South Kordufan, Sudan. Seven CCHF cases were involved in the outbreak; however, clinical specimens could be collected from only two patients, both of whom were confirmed as acute CCHF cases using CCHF-specific reverse transcriptase polymerase chain reaction (RT-PCR). Phylogenetic analysis of the complete S, M, and L segment sequences places the Abyei strain of CCHF virus in Group III, a virus group containing strains from various countries across Africa, including Sudan, South Africa, Mauritania, and Nigeria. The Abyei strain detected in 2009 is genetically distinct from the recently described 2008 Sudanese CCHF virus strains (Al-fulah 3 and 4), and the Abyei strain S and L segments closely match those of CCHF virus strain ArD39554 from Mauritania.
Conclusions: The present investigation illustrates that multiple CCHF virus lineages are circulating in the Kordufan region of Sudan and are associated with recent outbreaks of the disease occurring during 2008-2009.
C1 [Aradaib, Imadeldin E.; Mohamed, Mohamed E. H.] Univ Khartoum, Fac Vet Med, Dept Clin Med, Mol Biol Lab, Khartoum N, Sudan.
[Erickson, Bobbie R.; Nichol, Stuart T.] US Ctr Dis Control & Prevent, Mol Biol Lab, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA USA.
[Karsany, Mubarak S.; Elageb, Rehab M.] Fed Minist Hlth, Natl Med Hlth Lab, Div Virol, Khartoum, Sudan.
[Khristova, Marina L.] US Ctr Dis Control & Prevent, Div Sci Resources, Biotechnol Core Facil Branch, Atlanta, GA USA.
RP Aradaib, IE (reprint author), Univ Khartoum, Fac Vet Med, Dept Clin Med, Mol Biol Lab, Khartoum N, Sudan.
EM snichol@cdc.gov
FU University of Khartoum; Sudanese Ministry of Health; Centers for Disease
Control and Prevention, United States
FX This work was funded by the University of Khartoum, the Sudanese
Ministry of Health, and the Centers for Disease Control and Prevention,
United States. The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
NR 28
TC 16
Z9 18
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2727
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD MAY
PY 2011
VL 5
IS 5
AR e1159
DI 10.1371/journal.pntd.0001159
PG 9
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 770OZ
UT WOS:000291099100030
PM 21655310
ER
PT J
AU Njai, R
Siegel, PZ
Miller, JW
Liao, YL
AF Njai, Rashid
Siegel, Paul Z.
Miller, Jacqueline W.
Liao, Youlian
TI Misclassification of Survey Responses and Black-White Disparity in
Mammography Use, Behavioral Risk Factor Surveillance System, 1995-2006
SO PREVENTING CHRONIC DISEASE
LA English
DT Article
ID SELF-REPORTED MAMMOGRAPHY; AFRICAN-AMERICAN WOMEN; BREAST-CANCER;
ETHNIC-DIFFERENCES; PAP-SMEAR; POPULATION; INCOME; ACCURACY; VALIDITY;
STAGE
AB Introduction
The validity of self-reported data for mammography differ by race. We assessed the effect of racial differences in the validity of age-adjusted, self-reported mammography use estimates from the Behavioral Risk Factor Surveillance System (BRFSS) from 1995 through 2006 to determine whether misclassification (inaccurate survey question response) may have obscured actual racial disparities.
Methods
We adjusted BRFSS mammography use data for age by using 2000 census estimates and for misclassification by using the following formula: (estimated prevalence - 1 + specificity) / (sensitivity + specificity - 1). We used values reported in the literature for the formula (sensitivity = 0.97 for both black and white women, specificity = 0.49 and 0.62, respectively, for black and white women).
Results
After adjustment for misclassification, the percentage of women aged 40 years or older in 1995 who reported receiving a mammogram during the previous 2 years was 54% among white women and 41% among black women, compared with 70% among both white and black women after adjustment for age only. In 2006, the percentage after adjustment for misclassification was 65% among white women and 59% among black women compared with 77% among white women and 78% among black women after adjustment for age only.
Conclusion
Self-reported data overestimate mammography use - more so for black women than for white women. After adjustment for respondent misclassification, neither white women nor black women had attained the Healthy People 2010 objective (>= 70%) by 2006, and a disparity between white and black women emerged.
C1 [Njai, Rashid] Ctr Dis Control & Prevent, Community Hlth & Program Serv Branch, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA.
RP Njai, R (reprint author), Ctr Dis Control & Prevent, Community Hlth & Program Serv Branch, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy NE,MS K-30, Atlanta, GA 30341 USA.
EM RNjai@cdc.gov
NR 27
TC 10
Z9 11
U1 1
U2 4
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD MAY
PY 2011
VL 8
IS 3
AR A59
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 874OR
UT WOS:000298968400010
PM 21477499
ER
PT J
AU Mainzer, HM
Morrett, DB
AF Mainzer, Hugh M.
Morrett, Daphne B.
TI INTRODUCTION TO HEALTHY PEOPLE IN A HEALTHY ENVIRONMENT
SO PUBLIC HEALTH REPORTS
LA English
DT Editorial Material
C1 [Mainzer, Hugh M.; Morrett, Daphne B.] US PHS, Washington, DC 20201 USA.
[Mainzer, Hugh M.] Ctr Dis Control & Prevent CDC, Div Emergency & Environm Hlth Serv, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Morrett, Daphne B.] Agcy Tox Subst & Dis Registry, Div Hlth Assessment & Consultat, Atlanta, GA USA.
RP Mainzer, HM (reprint author), US PHS, Washington, DC 20201 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD MAY-JUN
PY 2011
VL 126
SU 1
BP 1
EP 2
PG 2
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 752AK
UT WOS:000289659700001
PM 21563705
ER
PT J
AU Somers, TS
Harvey, ML
Rusnak, SM
AF Somers, Tarah S.
Harvey, Margaret L.
Rusnak, Sharee Major
TI Making Child Care Centers SAFER: A Non-Regulatory Approach to Improving
Child Care Center Siting
SO PUBLIC HEALTH REPORTS
LA English
DT Article
AB Licensed child care centers are generally considered to be safe because they are required to meet state licensing regulations. As part of their licensing requirements, many states inspect child care centers and include an assessment of the health and safety of the facility to look for hazardous conditions or practices that may harm children. However, most states do not require an environmental assessment of the child care center building or land to prevent a center from being placed on, next to, or inside contaminated buildings. Having worked on several sites where child care centers were affected by environmental contaminants, the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry (ATSDR) endeavor to raise awareness of this issue. One of ATSDR's partner states, Connecticut, took a proactive, non-regulatory approach to the issue with the development its Child Day Care Screening Assessment for Environmental Risk Program.
C1 [Somers, Tarah S.] Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry Reg 1, Boston, MA 02109 USA.
[Harvey, Margaret L.; Rusnak, Sharee Major] Environm & Occupat Hlth Assessment Program, Environm Hlth Sect, Connecticut Dept Publ Hlth, Hartford, CT USA.
RP Somers, TS (reprint author), Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry Reg 1, 5 Post Off Sq,Ste 1010,Mail Code ATSDR10-1, Boston, MA 02109 USA.
EM TVS4@cdc.gov
NR 12
TC 3
Z9 3
U1 0
U2 2
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD MAY-JUN
PY 2011
VL 126
SU 1
BP 34
EP 40
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 752AK
UT WOS:000289659700006
PM 21563710
ER
PT J
AU Speers, S
Klevens, RM
Vonderwahl, C
Bryant, T
Daniloff, E
Capizzi, J
Poissant, T
Roome, A
AF Speers, Suzanne
Klevens, R. Monina
Vonderwahl, Candace
Bryant, Terry
Daniloff, Elaine
Capizzi, Jeff
Poissant, Tasha
Roome, Aaron
TI Electronic Matching of HIV/AIDS and Hepatitis C Surveillance Registries
in Three States
SO PUBLIC HEALTH REPORTS
LA English
DT Article
ID VIRUS-INFECTION; UNITED-STATES; HIV; PREVALENCE; HISTORY; MEN; SEX
AB Objectives. Both HIV and hepatitis C virus (HCV) can be transmitted through percutaneous exposure to blood in similar high-risk populations. HCV and HIV/AIDS surveillance databases were matched in Colorado, Connecticut, and Oregon to measure the frequency of co-infection and to characterize co-infected people.
Methods. We defined a case of HCV infection as a person with a reactive antibody for hepatitis C, medical diagnosis, positive viral-load test result, or positive genotype reported to any of three state health departments from the start of each state's hepatitis C registry through June 30, 2008. We defined a case of HIV/AIDS as a person diagnosed and living with HIV/AIDS at the start of each state's respective hepatitis C registry through June 30, 2008. HIV/AIDS and hepatitis C datasets were matched using Link King, public domain record linkage and consolidation software, and all potential matches were manually reviewed before acceptance as a match.
Results. The proportion of reported hepatitis C cases co-infected with HIV/AIDS was 1.8% in Oregon, 1.9% in Colorado, and 4.9% in Connecticut. Conversely, the proportion of HIV/AIDS cases co-infected with hepatitis C was consistently higher in the three states: 4.4% in Oregon, 9.7% in Colorado, and 23.6% in Connecticut.
Conclusions. Electronic matching of registries is a potentially useful and efficient way to transfer information from one registry to another. In addition, it can provide a measure of the public health burden of HIV/AIDS and hepatitis C co-infection and provide insight into prevention and medical care needs for respective states.
C1 [Speers, Suzanne; Roome, Aaron] Connecticut Dept Publ Hlth, HIV AIDS & Hepatitis Surveillance Program, Hartford, CT 06134 USA.
[Klevens, R. Monina] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Viral Hepatitis, Atlanta, GA USA.
[Vonderwahl, Candace; Bryant, Terry; Daniloff, Elaine] Colorado Dept Publ Hlth & Environm, Dis Control & Environm Epidemiol Div, Denver, CO USA.
[Capizzi, Jeff] Oregon Publ Hlth Div, HIV STD TB Program, Portland, OR USA.
RP Speers, S (reprint author), Connecticut Dept Publ Hlth, HIV AIDS & Hepatitis Surveillance Program, 410 Capitol Ave,MS 11ASV,POB 340308, Hartford, CT 06134 USA.
EM Suzanne.speers@ct.gov
FU Centers for Disease Control and Prevention (CDC); Emerging Infections
Program
FX Human immunodeficiency virus/acquired immunodeficiency syndrome
surveillance is funded by the Centers for Disease Control and Prevention
(CDC) under an HIV/AIDS Surveillance cooperative agreement. Hepatitis C
virus surveillance is funded under a cooperative agreement through CDC's
Emerging Infections Program. The matching project was a supplemental
project funded by the Emerging Infections Program hepatitis surveillance
cooperative agreement.
NR 16
TC 5
Z9 5
U1 0
U2 2
PU ASSOC SCHOOLS PUBLIC HEALTH
PI WASHINGTON
PA 1101 15TH ST NW, STE 910, WASHINGTON, DC 20005 USA
SN 0033-3549
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD MAY-JUN
PY 2011
VL 126
IS 3
BP 344
EP 348
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 752AJ
UT WOS:000289659600007
PM 21553662
ER
PT J
AU Hogben, M
Hood, J
AF Hogben, Matthew
Hood, Julia
TI Acquired Skills in Sexually Transmitted Disease Prevention: Partner
Services and Tailoring Interventions to Populations
SO SEXUALLY TRANSMITTED DISEASES
LA English
DT Editorial Material
ID INTERNET; INFECTIONS; RISK; HIV; SEX; NOTIFICATION; ATTITUDES; MEN; STD
C1 [Hogben, Matthew; Hood, Julia] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA.
RP Hogben, M (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Mail Stop E-44,1600 Clifton Rd, Atlanta, GA 30333 USA.
EM mhogben@cdc.gov
NR 13
TC 1
Z9 1
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0148-5717
J9 SEX TRANSM DIS
JI Sex. Transm. Dis.
PD MAY
PY 2011
VL 38
IS 5
BP 365
EP 366
DI 10.1097/OLQ.0b013e3182195fe7
PG 2
WC Infectious Diseases
SC Infectious Diseases
GA 749LN
UT WOS:000289468500002
PM 22256339
ER
PT J
AU Janusz, KB
Lehman, JA
Panella, AJ
Fischer, M
Staples, E
AF Janusz, Kristen B.
Lehman, Jennifer A.
Panella, Amanda J.
Fischer, Marc
Staples, Erin
TI Laboratory Testing Practices for West Nile Virus in the United States
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE ELISA; IgM; Laboratories; United States; West Nile virus
AB We surveyed state public health and commercial diagnostic reference laboratories regarding current testing practices for West Nile virus (WNV). The majority of WNV testing is now performed in commercial diagnostic reference laboratories using commercially available Food and Drug Administration-cleared kits labeled for the presumptive diagnosis of WNV. However, only 25% of surveyed state public health or commercial diagnostic reference laboratories currently have the capacity to perform the recommended confirmatory testing. These findings indicate the need for both manufacturers and laboratories to monitor the performance of these WNV test kits. Further, clinicians should be aware of the limitations of these kits and the need for additional testing to confirm a diagnosis of WNV disease.
C1 [Janusz, Kristen B.; Lehman, Jennifer A.; Panella, Amanda J.; Fischer, Marc; Staples, Erin] Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Dis, Ft Collins, CO 80521 USA.
RP Staples, E (reprint author), Ctr Dis Control & Prevent, Arboviral Dis Branch, Div Vector Borne Dis, 3150 Rampart Rd,Mailstop P-02, Ft Collins, CO 80521 USA.
EM estaples@cdc.gov
NR 9
TC 6
Z9 7
U1 0
U2 4
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD MAY
PY 2011
VL 11
IS 5
BP 597
EP 599
DI 10.1089/vbz.2010.0058
PG 3
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 765OD
UT WOS:000290717000020
PM 20849276
ER
PT J
AU Basavaraju, SV
Pitman, JP
Marum, LH
Zeh, C
Shiraishi, RW
Mwangi, J
Nyamongo, J
AF Basavaraju, S. V.
Pitman, J. P.
Marum, L. H.
Zeh, C.
Shiraishi, R. W.
Mwangi, J.
Nyamongo, J.
TI Author response to: letter to the editor HIV safety in sub-Saharan
Africa (vol 100, pg 436, 2011)
SO VOX SANGUINIS
LA English
DT Correction
C1 [Basavaraju, S. V.; Pitman, J. P.; Marum, L. H.; Shiraishi, R. W.] US Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA 30333 USA.
[Zeh, C.; Mwangi, J.] US Ctr Dis Control & Prevent, Kisumu, Kenya.
RP Basavaraju, SV (reprint author), US Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA 30333 USA.
EM etu7@cdc.gov
NR 1
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0042-9007
EI 1423-0410
J9 VOX SANG
JI Vox Sang.
PD MAY
PY 2011
VL 100
IS 4
BP 440
EP 440
DI 10.1111/j.1423-0410.2010.01460.x
PG 1
WC Hematology
SC Hematology
GA 750EX
UT WOS:000289529000017
ER
PT J
AU Schoenborn, CA
Stommel, M
AF Schoenborn, Charlotte A.
Stommel, Manfred
TI Adherence to the 2008 Adult Physical Activity Guidelines and Mortality
Risk
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID OF-SPORTS-MEDICINE; PUBLIC-HEALTH; OBESITY; OVERWEIGHT; RECOMMENDATION;
DISEASE; UNDERWEIGHT; INTENSITY; LIFE
AB Background: Mortality differentials by level and intensity of physical activity have been widely documented. A comprehensive review of scientific evidence of the health benefits of physical activity led the USDHHS to issue new Federal Guidelines for physical activity in 2008. Reductions in mortality risk associated with adherence to these Guidelines among the general U. S. adult population have not yet been studied.
Purpose: This study compared the relative mortality risks of U. S. adults who met the 2008 Guidelines with adults who did not meet the recommendations.
Methods: Cox proportional hazards models were used to examine the relative mortality risks of U. S. adults aged >= 18 years, using data from the 1997-2004 National Health Interview Survey and linked mortality records for deaths occurring in 1997-2006 (analyzed in 2010). Risks for adults with and without chronic health conditions were examined separately.
Results: Meeting the recommendations for aerobic activity was associated with substantial survival benefits, especially among the population having chronic conditions, with estimated hazard ratios ranging from 0.65 to 0.75 (p < 0.05). While strengthening activities by themselves did not appear to reduce mortality risks, they may provide added survival benefits to those already engaged in aerobic activities. The relative benefits of physical activity were greatest among adults who had at least one chronic condition.
Conclusions: Adherence to the 2008 Physical Activity Guidelines was associated with reduced all-cause mortality risks among U. S. adults, after controlling for sociodemographic characteristics, BMI, smoking, and alcohol use. (Am J Prev Med 2011; 40(5): 514-521) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine
C1 [Schoenborn, Charlotte A.] CDC, Div Hlth Interview Stat, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
[Stommel, Manfred] Michigan State Univ, Coll Nursing, E Lansing, MI 48824 USA.
RP Schoenborn, CA (reprint author), CDC, Div Hlth Interview Stat, Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 2331, Hyattsville, MD 20782 USA.
EM cas6@cdc.gov
NR 33
TC 39
Z9 41
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD MAY
PY 2011
VL 40
IS 5
BP 514
EP 521
DI 10.1016/j.amepre.2010.12.029
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 749YC
UT WOS:000289506900006
PM 21496750
ER
PT J
AU Kempe, A
Daley, MF
McCauley, MM
Crane, LA
Suh, CA
Kennedy, AM
Basket, MM
Stokley, SK
Dong, F
Babbel, CI
Seewald, LA
Dickinson, LM
AF Kempe, Allison
Daley, Matthew F.
McCauley, Mary M.
Crane, Lori A.
Suh, Christina A.
Kennedy, Allison M.
Basket, Michelle M.
Stokley, Shannon K.
Dong, Fran
Babbel, Christine I.
Seewald, Laura A.
Dickinson, L. Miriam
TI Prevalence of Parental Concerns About Childhood Vaccines The Experience
of Primary Care Physicians
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID AREA VACCINATION COVERAGE; AGED 19-35 MONTHS; UNITED-STATES; SAFETY
CONCERNS; NATIONAL-SURVEY; RISK/BENEFIT COMMUNICATION; PREVENTIVE CARE;
IMMUNIZATION; CHILDREN; MEASLES
AB Background: Little is known about the effects of increased parental vaccine safety concerns on physicians' vaccine communication attitudes and practices.
Purpose: To assess among pediatricians and family medicine (FM) physicians: (1) prevalence of parental requests to deviate from recommended vaccine schedules; (2) responses to such requests; and (3) attitudes about the burden and success of vaccine communications with parents.
Methods: Survey of nationally representative samples of pediatricians and FM physicians (N = 696) conducted during February to May 2009 with analysis in 2010.
Results: Response rates were 88% for pediatricians and 78% for FM physicians. Overall, 8% of physicians reported that >= 10% of parents refused a vaccine and 20% reported that >= 10% of parents requested to spread out vaccines in a typical month. More pediatricians than FM physicians reported always/often requiring parents to sign a form if they refused vaccination (53% vs 31%, p < 0.0001); 64% of all physicians would agree to spread out vaccines in the primary series at least sometimes. When talking with parents with substantial concerns, 53% of physicians reported spending 10-19 minutes and 8% spending >= 20 minutes. Pediatricians were more likely than FM physicians to report their job less satisfying because of parental vaccine concerns(46% vs 21%, p < 0.0001). Messages most commonly reported as "very effective" were personal statements such as what they would do for their own children.
Conclusions: The burden of communicating with parents about vaccines is high, especially among pediatricians. Physicians report the greatest success convincing skeptical parents using messages that rely on their personal choices and experiences. (Am J Prev Med 2011; 40(5): 548 -555) (C) 2011 American Journal of Preventive Medicine
C1 [Kempe, Allison; Daley, Matthew F.; Suh, Christina A.] Univ Colorado Denver, Dept Pediat, Denver, CO USA.
[Dickinson, L. Miriam] Univ Colorado Denver, Dept Family Med, Denver, CO USA.
[Kempe, Allison; Crane, Lori A.] Univ Colorado Denver, Colorado Sch Publ Hlth, Denver, CO USA.
[Kempe, Allison; Daley, Matthew F.; Dong, Fran] Univ Colorado Denver, Colorado Hlth Outcomes Program, Denver, CO USA.
[Kempe, Allison; Daley, Matthew F.; Crane, Lori A.; Suh, Christina A.; Dong, Fran; Babbel, Christine I.; Seewald, Laura A.; Dickinson, L. Miriam] Childrens Hosp, Childrens Outcomes Res Program, Aurora, CO USA.
[McCauley, Mary M.; Kennedy, Allison M.; Basket, Michelle M.; Stokley, Shannon K.] CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA.
RP Kempe, A (reprint author), 1056 E 19th Ave,B032, Denver, CO 80218 USA.
EM Kempe.allison@tchden.org
FU CDC PEP through the Association of American Medical Colleges, Washington
DC [MM-1040-08/08]
FX This investigation was funded by a grant from the CDC PEP
(MM-1040-08/08) through the Association of American Medical Colleges,
Washington DC. The findings and conclusions in this report are those of
the authors and do not necessarily represent the views of the CDC or the
USDHHS.
NR 33
TC 64
Z9 64
U1 8
U2 24
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD MAY
PY 2011
VL 40
IS 5
BP 548
EP 555
DI 10.1016/j.amepre.2010.12.025
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 749YC
UT WOS:000289506900010
PM 21496754
ER
PT J
AU Boland, JM
Vaszar, LT
Jones, JL
Mathison, BA
Rovzar, MA
Colby, TV
Leslie, KO
Tazelaar, HD
AF Boland, Jennifer M.
Vaszar, Laszlo T.
Jones, Jeffrey L.
Mathison, Blaine A.
Rovzar, Michael A.
Colby, Thomas V.
Leslie, Kevin O.
Tazelaar, Henry D.
TI Pleuropulmonary Infection by Paragonimus westermani in the United
States: A Rare Cause of Eosinophilic Pneumonia After Ingestion of Live
Crabs
SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY
LA English
DT Article
DE Paragonimus; P. westermani; paragonimiasis; pleuropulmonary parasitic
infection
ID NORTH-AMERICAN PARAGONIMIASIS; PULMONARY PARAGONIMIASIS; REFUGEE;
KELLICOTTI; DIAGNOSIS; CRAYFISH; RAW
AB Infections caused by the parasite Paragonimus westermani are endemic to Southeast Asia. Most infections reported in the United States are among immigrants who acquired the disease abroad. Due to the nonspecific nature of its presentation and rarity in the United States, the diagnosis may first be suggested by the pathologist on biopsy review. Definitive diagnosis may need serologic testing for confirmation. We report 4 cases of pleuropulmonary disease caused by United States-acquired P. westermani, which were identified in the consultation files of the authors. Patients (3 men and 1 woman; aged, 20 to 66 y) presented with pulmonary complaints and chest imaging abnormalities including cavitary infiltrates (2), lung mass (1), pleural effusion (1), and pneumothorax (1). Biopsies showed chronic eosinophilic pneumonia and organizing pneumonia in all cases. Other pathologic findings included granulomatous inflammation with geographic necrosis (3), vasculitis (3), and pleuritis (3). Paragonimus organisms and/or eggs were identified in 2 cases. Serologic studies were positive for P. westermani in 3 cases (2 enzyme-linked immunosorbent assay and 1 immunoblot). Three patients ate live crabs at sushi bars (including crabs in martinis, a previously unreported mechanism for infection). In 1 patient, the source of infection was uncertain. Paragonimiasis should be considered in the differential diagnosis of patients with eosinophilic pleuropulmonary disease in the United States. Although eosinophilic pneumonia was a consistent finding, the biopsies may be nonspecific as the organisms and/or eggs are not always visualized. Unusual features include marked pleuritis, foci of geographic necrosis and granulomatous vasculitis. A history of ingestion and targeted serologies are the keys to diagnosis.
C1 [Boland, Jennifer M.] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA.
[Vaszar, Laszlo T.; Colby, Thomas V.; Leslie, Kevin O.; Tazelaar, Henry D.] Mayo Clin, Scottsdale, AZ USA.
[Jones, Jeffrey L.; Mathison, Blaine A.] Ctr Dis Control & Prevent, Atlanta, GA USA.
[Rovzar, Michael A.] Mission Reg Med Ctr, Mission Viejo, CA USA.
RP Boland, JM (reprint author), Mayo Clin, Dept Lab Med & Pathol, 200 1st St SW, Rochester, MN 55905 USA.
EM boland.jennifer@mayo.edu
NR 23
TC 11
Z9 12
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0147-5185
J9 AM J SURG PATHOL
JI Am. J. Surg. Pathol.
PD MAY
PY 2011
VL 35
IS 5
BP 707
EP 713
DI 10.1097/PAS.0b013e318211acd9
PG 7
WC Pathology; Surgery
SC Pathology; Surgery
GA 749XZ
UT WOS:000289506600011
PM 21415702
ER
EF