FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Fox, DJ Pettygrove, S Cunniff, C O'Leary, LA Gilboa, SM Bertrand, J Druschel, CM Breen, A Robinson, L Ortiz, L Frias, JL Ruttenber, M Klumb, D Meaney, FJ AF Fox, Deborah J. Pettygrove, Sydney Cunniff, Christopher O'Leary, Leslie A. Gilboa, Suzanne M. Bertrand, Jacquelyn Druschel, Charlotte M. Breen, April Robinson, Luther Ortiz, Linnette Frias, Jaime L. Ruttenber, Margaret Klumb, Donald Meaney, F. John TI Fetal Alcohol Syndrome Among Children Aged 7-9 Years - Arizona, Colorado, and New York, 2010 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID UNITED-STATES; WOMEN C1 [Fox, Deborah J.; Druschel, Charlotte M.] New York State Dept Hlth, Bur Environm & Occupat Epidemiol, Albany, NY 12237 USA. [Pettygrove, Sydney] Univ Arizona, Coll Publ Hlth, Tucson, AZ 85721 USA. [Cunniff, Christopher; Ortiz, Linnette; Meaney, F. John] Univ Arizona, Dept Pediat, Tucson, AZ 85721 USA. [O'Leary, Leslie A.; Gilboa, Suzanne M.; Bertrand, Jacquelyn; Frias, Jaime L.] CDC, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Breen, April] New York State Dept Hlth, Western Reg Off, Albany, NY 12237 USA. [Robinson, Luther] Women & Childrens Hosp Buffalo, Buffalo, NY USA. [Frias, Jaime L.] McKing Consulting Corp, Fairfax, VA USA. [Klumb, Donald] Sewall Child Dev Ctr, Denver, CO USA. RP Fox, DJ (reprint author), New York State Dept Hlth, Bur Environm & Occupat Epidemiol, Albany, NY 12237 USA. EM deb.fox@health.ny.gov NR 9 TC 13 Z9 13 U1 1 U2 17 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 30 PY 2015 VL 64 IS 3 BP 54 EP 57 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ9IP UT WOS:000348527400002 PM 25632951 ER PT J AU Forrester, JD Kjemtrup, AM Fritz, CL Marsden-Haug, N Nichols, JB Tengelsen, LA Sowadsky, R DeBess, E Cieslak, PR Weiss, J Evert, N Ettestad, P Smelser, C Iralu, J Nett, RJ Mosher, E Baker, JS Van Houten, C Thorp, E Geissler, AL Kugeler, K Mead, P AF Forrester, Joseph D. Kjemtrup, Anne M. Fritz, Curtis L. Marsden-Haug, Nicola Nichols, Janell B. Tengelsen, Leslie A. Sowadsky, Rick DeBess, Emilio Cieslak, Paul R. Weiss, Joli Evert, Nicole Ettestad, Paul Smelser, Chad Iralu, Jonathan Nett, Randall J. Mosher, Elton Baker, JoDee Summers Van Houten, Clay Thorp, Emily Geissler, Aimee L. Kugeler, Kiersten Mead, Paul TI Tickborne Relapsing Fever - United States, 1990-2011 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID OUTBREAK C1 [Forrester, Joseph D.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Forrester, Joseph D.; Kugeler, Kiersten; Mead, Paul] CDC, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Tengelsen, Leslie A.] Idaho Dept Hlth & Welf, Pocatello, ID USA. [Sowadsky, Rick] Nevada Div Publ & Behav Hlth, Carson City, NV USA. [Ettestad, Paul; Smelser, Chad] New Mexico Dept Hlth, Epidemiol & Response Div, Santa Fe, NM USA. [Iralu, Jonathan] Gallup Indian Med Ctr, Indian Hlth Serv, Gallup, NM USA. [Baker, JoDee Summers] Utah Dept Hlth, Div Dis Control & Prevent, Salt Lake City, UT 84116 USA. [Van Houten, Clay; Thorp, Emily] Wyoming Dept Hlth, Cheyenne, WY USA. RP Forrester, JD (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM jforrester@cdc.gov NR 10 TC 3 Z9 3 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 30 PY 2015 VL 64 IS 3 BP 58 EP 60 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ9IP UT WOS:000348527400003 PM 25632952 ER PT J AU Rha, B Rudd, J Feikin, D Watson, J Curns, AT Swerdlow, DL Pallansch, MA Gerber, SI AF Rha, Brian Rudd, Jessica Feikin, Daniel Watson, John Curns, Aaron T. Swerdlow, David L. Pallansch, Mark A. Gerber, Susan I. TI Update on the Epidemiology of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection, and Guidance for the Public, Clinicians, and Public Health Authorities - January 2015 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Rha, Brian; Rudd, Jessica; Feikin, Daniel; Watson, John; Curns, Aaron T.; Pallansch, Mark A.; Gerber, Susan I.] CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Swerdlow, David L.] CDC, Off Director, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Rha, B (reprint author), CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM wif8@cdc.gov NR 2 TC 10 Z9 11 U1 0 U2 14 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 30 PY 2015 VL 64 IS 3 BP 61 EP 62 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ9IP UT WOS:000348527400004 PM 25632953 ER PT J AU Regan, JJ Jungerman, R Montiel, SH Newsome, K Objio, T Washburn, F Roland, E Petersen, E Twentyman, E Olaiya, O Naughton, M Alvarado-Ramy, F Lippold, SA Tabony, L McCarty, CL Kinsey, CB Barnes, M Black, S Azzam, I Stanek, D Sweitzer, J Valiani, A Kohl, KS Brown, C Pesik, N AF Regan, Joanna J. Jungerman, Robynne Montiel, Sonia H. Newsome, Kimberly Objio, Tina Washburn, Faith Roland, Efrosini Petersen, Emily Twentyman, Evelyn Olaiya, Oluwatosin Naughton, Mary Alvarado-Ramy, Francisco Lippold, Susan A. Tabony, Laura McCarty, Carolyn L. Kinsey, Cara Bicking Barnes, Meghan Black, Stephanie Azzam, Ihsan Stanek, Danielle Sweitzer, John Valiani, Anita Kohl, Katrin S. Brown, Clive Pesik, Nicki TI Public Health Response to Commercial Airline Travel of a Person with Ebola Virus Infection - United States, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID DISEASE OUTBREAK; NIGERIA C1 [Regan, Joanna J.; Jungerman, Robynne; Montiel, Sonia H.; Objio, Tina; Washburn, Faith; Roland, Efrosini; Naughton, Mary; Alvarado-Ramy, Francisco; Lippold, Susan A.; Kohl, Katrin S.; Brown, Clive; Pesik, Nicki] CDC, Div Global Migrat & Quarantine, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Newsome, Kimberly] CDC, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Petersen, Emily; Twentyman, Evelyn; Olaiya, Oluwatosin; McCarty, Carolyn L.; Kinsey, Cara Bicking] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Petersen, Emily; Twentyman, Evelyn; Olaiya, Oluwatosin] CDC, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [McCarty, Carolyn L.] Ohio Dept Hlth, Columbus, OH 43266 USA. [Kinsey, Cara Bicking] Penn Dept Hlth, Bur Epidemiol, Harrisburg, PA 17108 USA. [Sweitzer, John] Maryland Dept Hlth & Mental Hyg, Baltimore, MD 21201 USA. RP Regan, JJ (reprint author), CDC, Div Global Migrat & Quarantine, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM jregan@cdc.gov NR 8 TC 5 Z9 5 U1 1 U2 8 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 30 PY 2015 VL 64 IS 3 BP 63 EP 66 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ9IP UT WOS:000348527400005 PM 25632954 ER PT J AU Washington, ML Meltzer, ML AF Washington, Michael L. Meltzer, Martin L. TI Effectiveness of Ebola Treatment Units and Community Care Centers - Liberia, September 23-October 31, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Washington, Michael L.; Meltzer, Martin L.] CDC, Div Preparedness & Emerging Infect, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Washington, ML (reprint author), CDC, Div Preparedness & Emerging Infect, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM mwashington@cdc.gov NR 6 TC 5 Z9 5 U1 0 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 30 PY 2015 VL 64 IS 3 BP 67 EP 69 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ9IP UT WOS:000348527400006 PM 25632955 ER PT J AU Crowe, S Hertz, D Maenner, M Ratnayake, R Baker, P Lash, RR Klena, J Lee-Kwan, SH Williams, C Jonnie, GT Gorina, Y Anderson, A Saffa, G Carr, D Tuma, J Miller, L Turay, A Belay, E AF Crowe, Sam Hertz, Darren Maenner, Matt Ratnayake, Ruwan Baker, Pieter Lash, R. Ryan Klena, John Lee-Kwan, Seung Hee Williams, Candice Jonnie, Gabriel T. Gorina, Yelena Anderson, Alicia Saffa, Gbessay Carr, Dana Tuma, Jude Miller, Laura Turay, Alhajie Belay, Ermias TI A Plan for Community Event-Based Surveillance to Reduce Ebola Transmission - Sierra Leone, 2014-2015 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID WEST-AFRICA; VIRUS-DISEASE; EPIDEMIC; UGANDA C1 [Crowe, Sam; Maenner, Matt; Lee-Kwan, Seung Hee; Williams, Candice] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. RP Crowe, S (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM yeo2@cdc.gov NR 9 TC 7 Z9 7 U1 1 U2 6 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 30 PY 2015 VL 64 IS 3 BP 70 EP 73 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ9IP UT WOS:000348527400007 PM 25632956 ER PT J AU Ma, JB Li, P Zhao, XP Xu, HL Wu, WX Wang, YF Guo, YQ Wang, L Feng, YY Xiao, LH AF Ma, Jingbo Li, Pei Zhao, Xiaoping Xu, Hailing Wu, Wenxian Wang, Yuanfei Guo, Yaqiong Wang, Lin Feng, Yaoyu Xiao, Lihua TI Occurrence and molecular characterization of Cryptosporidium spp. and Enterocytozoon bieneusi in dairy cattle, beef cattle and water buffaloes in China SO VETERINARY PARASITOLOGY LA English DT Article DE Cryptosporidium; Enterocytozoon bieneusi; Cattle; SSU rRNA gene; ITS; Nested PCR ID EASTERN UNITED-STATES; ZOONOTIC TRANSMISSION; 1ST DETECTION; GIARDIA-DUODENALIS; NATIONAL-PARK; GENOTYPES; PREVALENCE; CALVES; DIARRHEA; FARMS AB Cryptosporidium spp. and Enterocytozoon bieneusi are important protists in a wide range of vertebrate hosts, causing diarrhea! diseases. Cattle are considered potential reservoirs of Cryptosporidium infection in humans, although their role in the transmission of E. bieneusi is not clear. In the present work, 793 fecal specimens from dairy cattle, native beef cattle, and water buffaloes on 11 farms in China were examined for the presence of Cryptosporidium spp. and E. bieneusi using nested PCR targeting the small subunit (SSU) rRNA gene of Cryptosporidium spp. and the internal transcribed spacer (ITS) of E. bieneusi. For Cryptosporidium, 144/446(32.3%) dairy cattle, 44/166(26.5%) beef cattle, and 43/181 (23.8%) water buffaloes were PCR-positive. Sequence analysis was successful for 213 of the 231 Cryptosporidium-positive isolates: among them 94 had Cryptosporidium andersoni, 61 had Cryptosporidium bovis, 54 had Cryptosporidium ryanae, 2 had a Cryptosporidium suis-like genotype, and 2 had mixed infections of C. bovis and C. ryanae. In dairy and beef cattle, C. andersoni and C. bovis were the most common species, whereas C. ryanae was the dominant species in water buffaloes. The latter species produced SSU rRNA sequences different between cattle and water buffaloes. For E. bieneusi, the infection rate of E. bieneusi in dairy cattle, beef cattle and water buffaloes was 4.9%, 5.4% and 2.2%, respectively. All 35 E. bieneusi-positive specimens were successfully sequenced, revealing the presence of four genotypes: three Group 2 genotypes previously reported in cattle as well as humans (I, J and BEB4) and one Group 1 genotype recently reported in yaks (CHN11). Genotypes I and J were the most common genotypes in dairy and beef cattle, while genotype CHN11 was the only genotype seen in water buffaloes. Thus, the distribution of Cryptosporidium spp. and E. bieneusi in water buffaloes might be different from in dairy and beef cattle in China. These findings indicate that some of the Cryptosporidium species and all four E. bieneusi genotypes identified in bovine animals in the study areas may have zoonotic potential. (C) 2014 Elsevier B.V. All rights reserved. C1 [Ma, Jingbo; Li, Pei; Xu, Hailing; Wu, Wenxian; Wang, Yuanfei; Guo, Yaqiong; Wang, Lin; Feng, Yaoyu] E China Univ Sci & Technol, Sch Resources & Environm Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. [Zhao, Xiaoping] Yueyang Ctr Anim Dis Control & Prevent, Yueyang 414000, Hunan, Peoples R China. [Xiao, Lihua] Ctr Dis Control & Prevent, Div Foodbome Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Feng, YY (reprint author), E China Univ Sci & Technol, Sch Resources & Environm Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. EM yyfeng@ecust.edu.cn RI Feng, Yaoyu/B-3076-2014; Yaqiong, Guo/N-4927-2015; Xiao, Lihua/B-1704-2013 OI Xiao, Lihua/0000-0001-8532-2727 FU National Natural Science Foundation of China [31110103901, 31229005]; National Special Fund for State Key Laboratory of Bioreactor Engineering [2060204]; Fundamental Research Funds for the Central Universities, China [WB1214073] FX This work was supported by National Natural Science Foundation of China (31110103901 and 31229005), National Special Fund for State Key Laboratory of Bioreactor Engineering (No. 2060204), and Fundamental Research Funds for the Central Universities, China (No. WB1214073). NR 73 TC 24 Z9 25 U1 3 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4017 EI 1873-2550 J9 VET PARASITOL JI Vet. Parasitol. PD JAN 30 PY 2015 VL 207 IS 3-4 BP 220 EP 227 DI 10.1016/j.vetpar.2014.10.011 PG 8 WC Parasitology; Veterinary Sciences SC Parasitology; Veterinary Sciences GA CA9UU UT WOS:000349271100004 PM 25541482 ER PT J AU Lindblade, KA Mwandama, D Mzilahowa, T Steinhardt, L Gimnig, J Shah, M Bauleni, A Wong, J Wiegand, R Howell, P Zoya, J Chiphwanya, J Mathanga, DP AF Lindblade, Kim A. Mwandama, Dyson Mzilahowa, Themba Steinhardt, Laura Gimnig, John Shah, Monica Bauleni, Andy Wong, Jacklyn Wiegand, Ryan Howell, Paul Zoya, John Chiphwanya, John Mathanga, Don P. TI A cohort study of the effectiveness of insecticide-treated bed nets to prevent malaria in an area of moderate pyrethroid resistance, Malawi SO MALARIA JOURNAL LA English DT Article DE Malaria; Insecticide-treated bed nets; Prevention; Vector control; Insecticide resistance ID PLASMODIUM-FALCIPARUM; MOSQUITO NETS; ANOPHELES-ARABIENSIS; WESTERN KENYA; COTE-DIVOIRE; IMPACT; TRANSMISSION; IMPREGNATION; PREVALENCE; FUNESTUS AB Background: Insecticide-treated bed nets (ITNs) are the cornerstone of malaria control in sub-Saharan Africa but their effectiveness may be compromised by the spread of pyrethroid resistance among malaria vectors. The objective of this investigation was to assess the effectiveness of ITNs to prevent malaria in an area of Malawi with moderate pyrethroid resistance. Methods: One deltamethrin ITN was distributed in the study area for every two individuals in each household plus one extra ITN for households with an odd number of residents. A fixed cohort of 1,199 children aged six to 59 months was seen monthly for one year and at sick visits to measure malaria infection and use of ITNs. Insecticide resistance among malaria vectors was measured. The effect of ITN use on malaria incidence was assessed, adjusting for potential confounders using generalized estimating equations accounting for repeated measures. Results: There were 1,909 infections with Plasmodium falciparum over 905 person-years at risk (PYAR), resulting in an observed incidence of 2.1 infections per person-year (iPPY). ITNs were used during 97% of the PYAR. The main vector was Anopheles funestus: mortality in WHO tube assays after exposure to 0.05% deltamethrin was 38% (95% confidence interval (CI) 29-47), and resistance was due to elevated oxidase enzymes. After adjusting for potential confounders, the incidence of malaria infection among ITN users was 1.7 iPPY (95% CI 1.5-2.1) and among non-bed net users was 2.6 iPPY (95% CI 2.0-3.3). Use of ITNs reduced the incidence of malaria infection by 30% (rate ratio 0.7; 95% CI, 0.5-0.8) compared to no bed nets. Conclusion: ITNs significantly reduced the incidence of malaria infection in children in an area with moderate levels of pyrethroid resistance and considerable malaria transmission. This is the first study to show that ITNs provide protection in areas where pyrethroid-resistant An. funestus is the major malaria vector. Malaria control programmes should continue to distribute and promote ITNs in areas with low to moderate pyrethroid resistance; however, insecticide resistance may intensify further and it is not known whether ITNs will remain effective at higher levels of resistance. There is an urgent need to identify or develop new insecticides and technologies to limit the vulnerability of ITNs to insecticide resistance. C1 [Lindblade, Kim A.; Steinhardt, Laura; Gimnig, John; Shah, Monica; Wong, Jacklyn; Wiegand, Ryan; Howell, Paul] US Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. [Mwandama, Dyson; Mzilahowa, Themba; Bauleni, Andy; Mathanga, Don P.] Malawi Coll Med, Malaria Alert Ctr, Blantyre, Malawi. [Zoya, John; Chiphwanya, John] Minist Publ Hlth, Natl Malaria Control Programme, Lilongwe, Malawi. RP Lindblade, KA (reprint author), US Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, 1600 Clifton Rd NE MS A-06, Atlanta, GA 30333 USA. EM kil2@cdc.gov FU US President's Malaria Initiative and CDC [3U01CK000135] FX The authors appreciate the support and cooperation of the Machinga District Hospital management team, traditional chiefs, nurses, interviewers, and all the children and caregivers who participated in the study. The authors thank Adam Wolkon for his excellent support to field data collection activities in mapping, enrolment and monthly interviews. Gerard W Lopez prepared the map. The study was made possible with funding from the US President's Malaria Initiative and CDC through Cooperative Agreement No. 3U01CK000135 between the CDC and the University of Malawi, College of Medicine. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 56 TC 13 Z9 13 U1 9 U2 22 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JAN 28 PY 2015 VL 14 AR 31 DI 10.1186/s12936-015-0554-1 PG 15 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CA4LU UT WOS:000348876400001 PM 25627987 ER PT J AU Samandari, T Agizew, TB Nyirenda, S Tedla, Z Sibanda, T Mosimaneotsile, B Motsamai, OI Shang, N Rose, CE Shepherd, J AF Samandari, Taraz Agizew, Tefera B. Nyirenda, Samba Tedla, Zegabriel Sibanda, Thabisa Mosimaneotsile, Barudi Motsamai, Oaitse I. Shang, Nong Rose, Charles E. Shepherd, James TI Tuberculosis incidence after 36 months' isoniazid prophylaxis in HIV-infected adults in Botswana: a posttrial observational analysis SO AIDS LA English DT Article DE antiretroviral therapy; HIV; isoniazid; preventive therapy; tuberculin; tuberculosis ID PLACEBO-CONTROLLED TRIAL; RIO-DE-JANEIRO; PREVENTIVE THERAPY; ANTIRETROVIRAL THERAPY; RANDOMIZED-TRIAL; SOUTH-AFRICA; DOUBLE-BLIND; SHORT-TERM; RISK; INITIATION AB Objective: Thirty-six months of isoniazid preventive therapy (36IPT) was superior to 6 months of IPT (6IPT) in preventing tuberculosis (TB) among HIV-infected adults in Botswana. We assessed the posttrial durability of this benefit. Design: A 36-month double-blind placebo controlled trial (1:1 randomization) with recruitment between November 2004 and July 2006 and observation until June 2011. Methods: One thousand, nine hundred and ninety-five participants were followed in eight public health clinics. Twenty-four percent had a tuberculin skin test >= 5mm (TST-positive). A minimum CD4(+) lymphocyte count was not required for enrolment. Antiretroviral therapy (ART) was provided in accordance with Botswana guidelines; 72% of participants retained by June 2011 had initiated ART. Multivariable analysis using Cox regression analysis included treatment arm, TST status, ART as a time-dependent variable and CD4(+) cell count at baseline and updated at 36 months. Results: In the posttrial period, 2.13 and 2.14 per 100 person-years accumulated, whereas 0.93 and 1.13% TB incidence rates were observed in the 36IPT and 6IPT arms, respectively (P = 0.52). The crude hazard ratio of TB during the trial and posttrial was 0.57 [95% confidence intervals (CI) 0.33, 0.99] and 0.82 (95% CI 0.46, 1.49), and when restricted to TST-positive participants was 0.26 (95% CI 0.08, 0.80) and 0.40 (95% CI 0.15, 1.08), respectively. Multivariable analysis showed that ART use was associated with reduced death (adjusted hazard ratio 0.36, 95% CI 0.17-0.75) but not TB (0.92, 95% CI 0.55-1.53) in the posttrial period. Conclusion: The benefit of 36IPT for TB prevention declined posttrial in this cohort. Adjunctive measures are warranted to prevent TB among HIV-infected persons receiving long-term ART in TB-endemic settings. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. C1 [Samandari, Taraz; Agizew, Tefera B.; Nyirenda, Samba; Tedla, Zegabriel; Sibanda, Thabisa; Mosimaneotsile, Barudi; Shepherd, James] Ctr Dis Control & Prevent Botswana, Gaborone, Botswana. [Samandari, Taraz; Agizew, Tefera B.; Nyirenda, Samba; Tedla, Zegabriel; Sibanda, Thabisa; Mosimaneotsile, Barudi; Shepherd, James] Ctr Dis Control & Prevent Botswana, Francistown, Botswana. [Samandari, Taraz; Shang, Nong; Shepherd, James] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA. [Motsamai, Oaitse I.] Minist Hlth, Gaborone, Botswana. [Rose, Charles E.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Samandari, T (reprint author), 1600 Clifton Rd NE,Mailstop E-45, Atlanta, GA 30329 USA. EM tts0@cdc.gov FU Centers for Disease Control and Prevention, Atlanta, Georgia, USA; U.S. Agency for International Development FX This work was supported by Centers for Disease Control and Prevention, Atlanta, Georgia, USA and U.S. Agency for International Development. NR 31 TC 7 Z9 8 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD JAN 28 PY 2015 VL 29 IS 3 BP 351 EP 359 DI 10.1097/QAD.0000000000000535 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AZ0SZ UT WOS:000347956200011 PM 25686683 ER PT J AU Denison, JA Koole, O Tsui, S Menten, J Torpey, K van Praag, E Mukadi, YD Colebunders, R Auld, AF Agolory, S Kaplan, JE Mulenga, M Kwesigabo, GP Wabwire-Mangen, F Bangsberg, DR AF Denison, Julie A. Koole, Olivier Tsui, Sharon Menten, Joris Torpey, Kwasi van Praag, Eric Mukadi, Ya Diul Colebunders, Robert Auld, Andrew F. Agolory, Simon Kaplan, Jonathan E. Mulenga, Modest Kwesigabo, Gideon P. Wabwire-Mangen, Fred Bangsberg, David R. TI Incomplete adherence among treatment-experienced adults on antiretroviral therapy in Tanzania, Uganda and Zambia SO AIDS LA English DT Article DE antiretroviral therapy; HIV/AIDS; medication adherence; sub-Saharan Africa; Tanzania; Uganda; Zambia ID SUB-SAHARAN AFRICA; SELF-REPORTED ADHERENCE; HIV-INFECTED PATIENTS; HIGH-INCOME COUNTRIES; MEDICATION ADHERENCE; VIROLOGICAL RESPONSE; CLINICAL-TRIALS; SOCIAL SUPPORT; NORTH-AMERICA; RURAL UGANDA AB Objectives: To characterize antiretroviral therapy (ART) adherence across different programmes and examine the relationship between individual and programme characteristics and incomplete adherence among ART clients in sub-Saharan Africa. Design: A cross-sectional study. Methods: Systematically selected ART clients (>= 18 years; on ART >= 6 months) attending 18facilities in three countries (250 clients/facility) were interviewed. Client self-reports (3-day, 30-day, Case Index >= 48 consecutive hours of missed ART), healthcare provider estimates and the pharmacymedication possession ratio(MPR) were used to estimate ART adherence. Participants from two facilities per country underwent HIV RNA testing. Optimal adherence measures were selected on the basis of degree of association with concurrent HIV RNA dichotomized at less than or greater/equal to 1000 copies/ml. Multivariate regression analysis, adjusted for site-level clustering, assessed associations between incomplete adherence and individual and programme factors. Results: A total of 4489 participants were included, of whom 1498 underwent HIV RNA testing. Nonadherence ranged from 3.2% missing at least 48 consecutive hours to 40.1% having an MPR of less than 90%. The percentage with HIV RNA at least 1000 copies/ml ranged from 7.2 to 17.2% across study sites (mean = 9.9%). Having at least 48 consecutive hours of missed ART was the adherence measure most strongly related to virologic failure. Factors significantly related to incomplete adherence included visiting a traditional healer, screening positive for alcohol abuse, experiencing more HIV symptoms, having an ART regimen without nevirapine and greater levels of internalized stigma. Conclusion: Results support more in-depth investigations of the role of traditional healers, and the development of interventions to address alcohol abuse and internalized stigma among treatment-experienced adult ART patients. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. C1 [Denison, Julie A.; Tsui, Sharon; Torpey, Kwasi; van Praag, Eric; Mukadi, Ya Diul] FHI 360, Social & Behav Hlth Sci, Durham, NC USA. [Denison, Julie A.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA. [Koole, Olivier; Menten, Joris; Colebunders, Robert] Inst Trop Med, B-2000 Antwerp, Belgium. [Koole, Olivier] London Sch Hyg & Trop Med, London WC1, England. [Colebunders, Robert] Univ Antwerp, B-2020 Antwerp, Belgium. [Auld, Andrew F.; Agolory, Simon; Kaplan, Jonathan E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Mulenga, Modest] Trop Dis Res Ctr, Ndola, Zambia. [Kwesigabo, Gideon P.] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania. [Wabwire-Mangen, Fred] Makerere Univ, Coll Hlth Sci, Infect Dis Inst, Kampala, Uganda. [Bangsberg, David R.] Massachusetts Gen Hosp, Boston, MA 02114 USA. RP Denison, JA (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, 615 N Wolfe St,E5032, Baltimore, MD 21205 USA. EM jdenison@jhu.edu OI Auld, Andrew/0000-0001-5089-9163 FU President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC); Health Resources & Services Administration (HRSA) [2006-N-08428]; FHI [360] FX This research has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC) and the Health Resources & Services Administration (HRSA) under the terms of the contract no. 2006-N-08428 with FHI 360. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the official position of CDC, HRSA or any other federal agency or office. NR 65 TC 10 Z9 10 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD JAN 28 PY 2015 VL 29 IS 3 BP 361 EP 371 DI 10.1097/QAD.0000000000000543 PG 11 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA AZ0SZ UT WOS:000347956200012 PM 25686684 ER PT J AU Walaza, S Tempia, S Dawood, H Variava, E Moyes, J Cohen, AL Wolter, N Groome, M von Mollendorf, C Kahn, K Pretorius, M Venter, M Madhi, SA Cohen, C AF Walaza, Sibongile Tempia, Stefano Dawood, Halima Variava, Ebrahim Moyes, Jocelyn Cohen, Adam L. Wolter, Nicole Groome, Michelle von Mollendorf, Claire Kahn, Kathleen Pretorius, Marthi Venter, Marietjie Madhi, Shabir A. Cohen, Cheryl TI Influenza virus infection is associated with increased risk of death amongst patients hospitalized with confirmed pulmonary tuberculollsis in South Africa, 2010-2011 SO BMC INFECTIOUS DISEASES LA English DT Article DE Influenza; Tuberculosis; Co-infection; South Africa ID HIGH HIV PREVALENCE; COMMUNITY-ACQUIRED PNEUMONIA; UNITED-STATES; YOUNG-CHILDREN; MORTALITY; TIME; SUPERINFECTION; INFANTS; SPUTUM; MICE AB Background: Data on the association between influenza and tuberculosis are limited. We describe the characteristics of patients with laboratory-confirmed tuberculosis, laboratory-confirmed influenza and tuberculosis-influenza co-infection. Methods: Patients hospitalized with severe respiratory illness (acute and chronic) were enrolled prospectively in four provinces in South Africa. Naso/oropharyngeal specimens were tested for influenza virus by real time reverse transcriptase polymerase chain reaction. Tuberculosis testing was conducted as part of clinical management. Results: From June 2010 through December 2011, 8032 patients were enrolled and influenza testing was conducted on 7863 (98%). Influenza virus was detected in 765 (10%) patients. Among 2959 patients with tuberculosis and influenza results, 2227 (75%) were negative for both pathogens, 423 (14%) were positive for tuberculosis alone, 275 (9%) were positive for influenza alone and 34 (1%) had influenza and tuberculosis co-infection. On multivariable analysis amongst individuals with symptoms for = 7 days, tuberculosis influenza co-infection was associated with increased risk of death, (adjusted relative risk ratio (aRRR) (6.1, 95% confidence interval (CI) 1.6-23.4), as compared to tuberculosis only infection. This association was not observed in individuals with symptoms for < 7 days (aRRR. 0.8, 95% CI 0.1-7.0). Conclusion: Tuberculosis and influenza co-infection compared to tuberculosis single infection was associated with increased risk of death in individuals with symptoms >= 7 days. The potential public health impact of influenza vaccination among persons with laboratory-confirmed tuberculosis should be explored. C1 [Walaza, Sibongile; Moyes, Jocelyn; Wolter, Nicole; von Mollendorf, Claire; Pretorius, Marthi; Venter, Marietjie; Madhi, Shabir A.; Cohen, Cheryl] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Ctr Resp Dis & Meningitis, ZA-2131 Johannesburg, Gauteng, South Africa. [Walaza, Sibongile; Moyes, Jocelyn; von Mollendorf, Claire; Cohen, Cheryl] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa. [Tempia, Stefano; Cohen, Adam L.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Tempia, Stefano; Cohen, Adam L.] US Ctr Dis Control & Prevent, Pretoria, South Africa. [Groome, Michelle] Univ Witwatersrand, Natl Res Fdn Vaccine Preventable Dis, MRC, Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa. [Groome, Michelle] Univ Witwatersrand, Dept Sci & Technol, Johannesburg, South Africa. [Dawood, Halima] Pietermaritzburg Metropolitan Hosp Complex, Kwa Zulu, South Africa. [Kahn, Kathleen] MRC Wits Rural Publ Hlth & Hlth Transit Res Unit, Bushbuckridge, South Africa. [Variava, Ebrahim] Tshepong Hosp, ZA-2570 Klerksdorp, North West Prov, South Africa. [Variava, Ebrahim] Univ Witwatersrand, Fac Med, Johannesburg, South Africa. [Venter, Marietjie] Univ Pretoria, Dept Med Virol, Zoonosis Res Unit, ZA-0001 Pretoria, South Africa. RP Walaza, S (reprint author), Natl Hlth Lab Serv, Natl Inst Communicable Dis, Ctr Resp Dis & Meningitis, Private Bag X4, ZA-2131 Johannesburg, Gauteng, South Africa. EM sibongilew@nicd.ac.za; cherylc@nicd.ac.za RI Venter, Marietjie/P-9604-2016 OI Venter, Marietjie/0000-0003-2696-824X NR 37 TC 7 Z9 7 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD JAN 27 PY 2015 VL 15 AR 26 DI 10.1186/s12879-015-0746-x PG 13 WC Infectious Diseases SC Infectious Diseases GA CA4LW UT WOS:000348876500001 PM 25623944 ER PT J AU Mayagaya, VS Ntamatungiro, AJ Moore, SJ Wirtz, RA Dowell, FE Maia, MF AF Mayagaya, Valeriana Simon Ntamatungiro, Alex John Moore, Sarah Jane Wirtz, Robert Andrew Dowell, Floyd Ercell Maia, Marta Ferreira TI Evaluating preservation methods for identifying Anopheles gambiae s.s. and Anopheles arabiensis complex mosquitoes species using near infra-red spectroscopy SO PARASITES & VECTORS LA English DT Article DE Near-infrared spectroscopy; Anopheles gambiae s.s; Anopheles arabiensis; Species identification; Preservation methods; Malaria ID INOCULATION RATES; MALARIA CONTROL; AGE; BEHAVIOR; AFRICA; TRANSMISSION; MORTALITY; NETS AB Background: Near-infrared spectroscopy (NIRS) has been successfully used on fresh and RNAlater (R)-preserved members of the Anopheles gambiae complex to identify sibling species and age. No preservation methods other than using RNAlater (R) have been tested to preserve mosquitoes for species identification using NIRS. However, RNAlater (R) is not the most practical preservative for field settings because it is expensive, requires basic laboratory conditions for storage and is not widely available in sub-Saharan Africa. The aim of this study was to test several cheaper and more field-friendly preservation methods for identifying sibling species of the An. gambiae complex using NIRS. Methods: In this study we describe the use of NIRS to identify sibling species of preserved An. gambiae s.s. and An. arabiensis. Mosquitoes of each species were placed in sample tubes and preserved using one of the following preservation methods: (i) refrigeration at 4 degrees C, (ii) freezing at -20 degrees C, (iii) drying over a silica-gel desiccant, (iv) submersion in RNAlater (R) at room temperature, (v) submersion in RNAlater (R) at 4 degrees C, and (vi) submersion in RNAlater (R) at -20 degrees C. Mosquitoes were preserved for 1, 4, 10, 32 or 50 weeks before they were scanned. Results: Storage at 4 degrees C was the only preservation method that, up to 32 weeks, did not result in significantly lower predicted values than those obtained from fresh insects. After 50 weeks, however, refrigerated samples did not give meaningful results. When storing for 50 weeks, desiccating samples over silica gel was the best preservation method, with a partial least squares regression cross-validation of >80%. Predictive data values were analyzed using a generalized linear model. Conclusion: NIRS can be used to identify species of desiccated Anopheles gambiae s.s. and Anopheles arabiensis for up to 50 weeks of storage with more than 80% accuracy. C1 [Mayagaya, Valeriana Simon; Ntamatungiro, Alex John; Moore, Sarah Jane; Maia, Marta Ferreira] Ifakara Hlth Inst, Ifakara, Tanzania. [Ntamatungiro, Alex John] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England. [Moore, Sarah Jane; Maia, Marta Ferreira] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland. [Moore, Sarah Jane; Maia, Marta Ferreira] Univ Basel, CH-4003 Basel, Switzerland. [Wirtz, Robert Andrew] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Dowell, Floyd Ercell] USDA ARS, Ctr Grain & Anim Hlth Res, Engn & Wind Eros Res Unit, Manhattan, KS USA. RP Mayagaya, VS (reprint author), Ifakara Hlth Inst, POB 53, Ifakara, Tanzania. EM vmayagaya@ihi.or.tz OI Ferreira Maia, Marta/0000-0003-3302-5610 FU Centers for Disease Control and Prevention (CDC) FX Our gratitude goes to Ally Daraja, Paulina Kasanga, Neema Nombo and Zuhura Kondo for rearing the mosquitoes we used in this study. This study was funded by the Centers for Disease Control and Prevention (CDC). NR 15 TC 4 Z9 4 U1 1 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD JAN 27 PY 2015 VL 8 AR 60 DI 10.1186/s13071-015-0661-4 PG 6 WC Parasitology SC Parasitology GA CB1XH UT WOS:000349420800001 PM 25623484 ER PT J AU Rabe, IB Miller, ER Fischer, M Hills, SL AF Rabe, Ingrid B. Miller, Elaine R. Fischer, Marc Hills, Susan L. TI Adverse events following vaccination with an inactivated, Vero cell culture-derived Japanese encephalitis vaccine in the United States, 2009-2012 SO VACCINE LA English DT Article DE Japanese encephalitis vaccines; Vaccines; United States; Public health surveillance ID IMMUNIZATION SAFETY DATA; CASE-DEFINITION; DATA-COLLECTION; GUIDELINES; IXIARO(R); TRIAL; IC51 AB Background: In March 2009, the U.S. Food and Drug Administration licensed an inactivated, Vero cell culture-derived Japanese encephalitis vaccine (JE-VC [Ixiaro]) for use in adults. The vaccine was licensed based on clinical trial safety data in 3558 JE-VC recipients. It is essential to monitor post-licensure surveillance data to evaluate the safety ofJE-VC because rare adverse events may not be detected until the vaccine is administered to a larger population. Methods: We reviewed adverse events reported to the U.S. Vaccine Adverse Event Reporting System (VAERS) for adults (>= 17 years) who received JE-VC from May 2009 through April 2012. Adverse event reporting rates were calculated using 275,848 JE-VC doses distributed. Results: Over the 3 year period, 42 adverse events following vaccination with JE-VC were reported to VAERS for an overall reporting rate of 15.2 adverse events per 100,000 doses distributed. Of the 42 total reports, 5 (12%) were classified as serious for a reporting rate of 1.8 per 100,000 doses distributed; there were no deaths. Hypersensitivity reactions (N= 12) were the most commonly reported type of adverse event, with a rate of 4.4 per 100,000 doses distributed; no cases of anaphylaxis were reported. Three adverse events of the central nervous system were reported (one case of encephalitis and two seizures) for a rate of 1.1 per 100,000; all occurred after receipt of JE-VC with other vaccines. Conclusions: These post-marketing surveillance data suggest a good safety profile for JE-VC consistent with findings from pre-licensure clinical trials. Post-licensure safety data should continue to be monitored for any evidence of rare serious or neurologic adverse events. Published by Elsevier Ltd. C1 [Rabe, Ingrid B.; Fischer, Marc; Hills, Susan L.] Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO 80521 USA. [Miller, Elaine R.] Ctr Dis Control & Prevent, Immunizat Safety Off, Atlanta, GA 30333 USA. RP Rabe, IB (reprint author), Ctr Dis Control & Prevent, Arboviral Dis Branch, 3156 Rampart Rd,Mail Stop P-02, Ft Collins, CO 80521 USA. EM irabe@cdc.gov NR 21 TC 4 Z9 4 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 25 PY 2015 VL 33 IS 5 BP 708 EP 712 DI 10.1016/j.vaccine.2014.11.046 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CB3BR UT WOS:000349503700019 PM 25498208 ER PT J AU Saha, S Modak, JK Naziat, H Al-Emran, HM Chowdury, M Islam, M Hossain, B Darmstadt, GL Whitney, CG Saha, SK AF Saha, Sudipta Modak, Joyanta K. Naziat, Hakka Al-Emran, Hassan M. Chowdury, Mrittika Islam, Maksuda Hossain, Belal Darmstadt, Gary L. Whitney, Cynthia G. Saha, Samir K. TI Detection of co-colonization with Streptococcus pneumoniae by algorithmic use of conventional and molecular methods SO VACCINE LA English DT Article DE Pneumococcus; Carriage; Co-colonization; Quantitative detection ID INVASIVE PNEUMOCOCCAL DISEASE; SEROTYPES; CARRIAGE; VACCINE; IDENTIFICATION; SURVEILLANCE; MICROARRAY; IDENTIFY; CHILDREN AB Detection of pneumococcal carriage by multiple co-colonizing serotypes is important in assessing the benefits of pneumococcal conjugate vaccine (PCV). Various methods differing in sensitivity, cost and technical complexity have been employed to detect multiple serotypes of pneumococcus in respiratory specimens. We have developed an algorithmic method to detect all known serotypes that preserves the relative abundance of specific serotypes by using Quellung-guided molecular techniques. The method involves culturing respiratory swabs followed by serotyping of 100 colonies by either capsular (10 colonies) or PCR (90 colonies) reactions on 96-well plates. The method was evaluated using 102 nasal swabs from children carrying pneumococcus. Multiple serotypes were detected in 22% of carriers, compared to 3% by World Health Organization (WHO)-recommended morphology-based selection of 1 to 3 colonies. Our method, with a processing cost of $87, could detect subdominant strains making up as low as 1% of the population. The method is affordable, practical, and capable of detecting all known serotypes without false positive reactions or change in the native distribution of multiple serotypes. (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-SA license. C1 [Saha, Sudipta; Modak, Joyanta K.; Naziat, Hakka; Al-Emran, Hassan M.; Chowdury, Mrittika; Islam, Maksuda; Hossain, Belal; Saha, Samir K.] Bangladesh Inst Child Hlth, Dhaka Shishu Hosp, Dept Microbiol, Child Hlth Res Fdn, Dhaka, Bangladesh. [Darmstadt, Gary L.] Bill & Melinda Gates Fdn, Global Dev Div, Seattle, WA USA. [Whitney, Cynthia G.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Saha, SK (reprint author), Bangladesh Inst Child Hlth, Dhaka Shishu Hosp, Dept Microbiol, Child Hlth Res Fdn, Dhaka, Bangladesh. EM Samir@chrfbd.org FU Child Health Research Foundation FX This study was partially supported by Child Health Research Foundation. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the funding agencies. NR 17 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 25 PY 2015 VL 33 IS 5 BP 713 EP 718 DI 10.1016/j.vaccine.2014.11.040 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CB3BR UT WOS:000349503700020 PM 25523524 ER PT J AU Li, SJ Sun, QZ Wei, XY Klena, JD Wang, JP Liu, Y Tian, KC Luo, X Ye, CY Xu, JG Wang, DM Tang, GP AF Li, Shijun Sun, Qiangzheng Wei, Xiaoyu Klena, John D. Wang, Jianping Liu, Ying Tian, Kecheng Luo, Xia Ye, Changyun Xu, Jianguo Wang, Dingming Tang, Guangpeng TI Genetic Characterization of Shigella flexneri Isolates in Guizhou Province, China SO PLOS ONE LA English DT Article ID TANDEM-REPEAT ANALYSIS; ASIAN COUNTRIES; DISEASE BURDEN; SALMONELLA; PULSENET; SONNEI AB Shigella flexneri is one of the major etiologic causes of shigellosis in Guizhou Province, China. However, the genetic characteristics of circulating isolates are unknown. Phenotypic and molecular profiles of 60 S. flexneri isolates recovered in Guizhou between 1972 to 1982 and 2008 to 2010 were determined. Nine serotypes (1a, 2a, 3a, 1b, 2b, X, Y, 4av and Yv) were identified. Multi-locus sequence typing differentiated the isolates into 20 sequence types (STs); 18 were novel. Four STs, ST 129, ST 100, ST 126 and ST 18, were most abundant, accounting for 65% of the isolates. Thirty-nine NotI-pulsed field gel electrophoresis patterns (pulsotypes, PTs) were observed; eight PTs were represented by more than one isolate with six isolates sharing the PT 13 profile. Multi-locus variable-nucleotide tandem-repeat analysis recognized 44 different types (MTs); seven MTs were represented by more than one isolate and MT 1 was most commonly encountered. Correlation between genetic relationships and serotypes was observed among the isolates studied; the majority of isolates belonging to the same serotype from different years clustered together based on the molecular data. These clustered isolates were also from similar geographical origins. These results enhance our understanding of genetic relationships between S. flexneri in Guizhou Province and can be used to help understand the changing etiology of shigellosis in China. C1 [Li, Shijun; Wei, Xiaoyu; Liu, Ying; Tian, Kecheng; Wang, Dingming; Tang, Guangpeng] Guizhou Prov Ctr Dis Control & Prevent, Inst Communicable Dis Control & Prevent, Guiyang 550004, Guizhou, Peoples R China. [Sun, Qiangzheng; Wang, Jianping; Luo, Xia; Ye, Changyun; Xu, Jianguo] China CDC, Natl Inst Communicable Dis Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China. [Klena, John D.] US Ctr Dis Control & Prevent, Int Emerging Infect Program, Beijing, Peoples R China. [Klena, John D.] Ctr Dis Control & Prevent, Global Dis Detect Branch, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA USA. RP Li, SJ (reprint author), Guizhou Prov Ctr Dis Control & Prevent, Inst Communicable Dis Control & Prevent, 101 Bageyan Rd, Guiyang 550004, Guizhou, Peoples R China. EM zjumedjun@163.com FU grant of national science and technology major project of China [2009ZX10602-12]; Talent Base Funds for Infectious Disease Control and Prevention in Guizhou Provincial Government [Qian Ren Ling Fa [2013]15]; National Natural Science Foundation of China [81271788, 81290345]; National Basic Research Priorities Program [2011CB504901]; National Key Program for Infectious Diseases of China [2013ZX10004221, 013ZX10004216-001-002, 2ZX10004215] FX This work was supported by the grant of national science and technology major project of China (No. 2009ZX10602-12), Talent Base Funds for Infectious Disease Control and Prevention in Guizhou Provincial Government (No. Qian Ren Ling Fa [2013]15), National Natural Science Foundation of China (No. 81271788 and 81290345), National Basic Research Priorities Program (No. 2011CB504901) and National Key Program for Infectious Diseases of China (No. 2013ZX10004221, 013ZX10004216-001-002 and 2ZX10004215. We acknowledge the use of the EcMLST database which is operated by the Microbial Evolution Laboratory at Michigan State University. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 27 TC 0 Z9 1 U1 2 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 24 PY 2015 VL 10 IS 1 AR e0116708 DI 10.1371/journal.pone.0116708 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CC4PT UT WOS:000350336000021 PM 25617838 ER PT J AU Alkoshi, S Leshem, E Parashar, UD Dahlui, M AF Alkoshi, Salem Leshem, Eyal Parashar, Umesh D. Dahlui, Maznah TI Anticipating rotavirus vaccines - a pre-vaccine assessment of incidence and economic burden of rotavirus hospitalizations among children < 5 year of age in Libya, 2012-13 SO BMC PUBLIC HEALTH LA English DT Article DE Diarrhea; Rotavirus; Hospitalization; Incidence rate; Treatment cost; Libya ID DIARRHEA; IMPACT AB Background: Libya introduced rotavirus vaccine in October 2013. We examined pre-vaccine incidence of rotavirus hospitalizations and associated economic burden among children < 5 years in Libya to provide baseline data for future vaccine impact evaluations. Methods: Prospective, hospital-based active surveillance for rotavirus was conducted at three public hospitals in two cities during August 2012 - April 2013. Clinical, demographic and estimated cost data were collected from children < 5 hospitalized for diarrhea; stool specimens were tested for rotavirus with a commercial enzyme immunoassay. Annual rotavirus hospitalization incidence rate estimates included a conservative estimate based on the number of cases recorded during the nine months and an extrapolation to estimate 12 months incidence rate. National rotavirus disease and economic burden were estimated by extrapolating incidence and cost data to the national population of children aged < 5 years. Results: A total of 410 children < 5 years of age with diarrhea were enrolled, of whom 239 (58%) tested positive rotavirus, yielding an incidence range of 418-557 rotavirus hospitalizations per 100,000 children < 5 years of age. Most (86%) rotavirus cases were below two years of age with a distinct seasonal peak in winter (December-March) months. The total cost of treatment for each rotavirus patient was estimated at US$ 679 (range: 200-5,423). By extrapolation, we estimated 2,948 rotavirus hospitalizations occur each year in Libyan children < 5 years of age, incurring total costs of US$ 2,001,662 (range: 1,931,726-2,094,005). Conclusions: Rotavirus incurs substantial morbidity and economic burden in Libya, highlighting the potential value of vaccination of Libyan children against rotavirus. C1 [Alkoshi, Salem; Dahlui, Maznah] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia. [Leshem, Eyal; Parashar, Umesh D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Alkoshi, S (reprint author), Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia. EM alkushis@yahoo.com RI DAHLUI, MAZNAH/B-8976-2010; OI DAHLUI, MAZNAH/0000-0003-4923-9410; Leshem, Eyal/0000-0003-1267-6131 FU University of Malaya/Ministry of Higher Education (UM/MOHE) High Impact Research Grant, Malaysia [E000010-20001]; AADUN [RP026-2012C] FX Authors appreciate the great help for the national laboratory at the NCDC, staffs at the hospitals. We are grateful to the parents who participated in the study. The study was supported by the University of Malaya/Ministry of Higher Education (UM/MOHE) High Impact Research Grant (E000010-20001), Malaysia, and also supported by the AADUN RP026-2012C grant. NR 24 TC 2 Z9 2 U1 1 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD JAN 24 PY 2015 VL 15 AR 26 DI 10.1186/s12889-015-1400-7 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB1VG UT WOS:000349415500001 PM 25616973 ER PT J AU Zhu, Z Rivailler, P Abernathy, E Cui, AL Zhang, Y Mao, NY Xu, ST Zhou, SJ Lei, Y Wang, Y Zheng, HY He, JL Chen, Y Li, CS Bo, F Zhao, CF Chen, M Lu, PS Li, FC Gu, SY Gao, H Guo, Y Chen, H Feng, DX Wang, S Tang, XM Lei, YK Feng, Y Deng, LL Gong, T Fan, LX Xu, WB Icenogle, J AF Zhu, Zhen Rivailler, Pierre Abernathy, Emily Cui, Aili Zhang, Yan Mao, Naiyin Xu, Songtao Zhou, Shujie Lei, Yue Wang, Yan Zheng, Huanying He, Jilan Chen, Ying Li, Chongshan Bo, Fang Zhao, Chunfang Chen, Meng Lu, Peishan Li, Fangcai Gu, Suyi Gao, Hui Guo, Yu Chen, Hui Feng, Daxing Wang, Shuang Tang, Xiaomin Lei, Yake Feng, Yan Deng, Lili Gong, Tian Fan, Lixia Xu, Wenbo Icenogle, Joseph CA Rubella Virology Surveillance TI Evolutionary analysis of rubella viruses in mainland China during 2010-2012: endemic circulation of genotype 1E and introductions of genotype 2B SO SCIENTIFIC REPORTS LA English DT Article ID VIROLOGICAL SURVEILLANCE; GENETIC-VARIABILITY; UNITED-STATES; EPIDEMIC; SEQUENCES; AMERICA; VACCINE AB Rubella remains a significant burden in mainland China. In this report, 667 viruses collected in 24 of 31 provinces of mainland China during 2010-2012 were sequenced and analyzed, significantly extending previous reports on limited numbers of viruses collected before 2010. Only viruses of genotypes 1E and 2B were found. Genotype 1E viruses were found in all 24 provinces. Genotype 1E viruses were likely introduced into mainland China around 1997 and endemic transmission of primarily one lineage became established. Viruses reported here from 2010-2012 are largely in a single cluster within this lineage. Genotype 2B viruses were rarely detected in China prior to 2010. This report documents a previously undetected 2B lineage, which likely became endemic in eastern provinces of China between 2010 and 2012. Bayesian analyses were performed to estimate the evolutionary rates and dates of appearance of the genotype 1E and 2B viral linages in China. A skyline plot of viral population diversity did not provide evidence of reduction of diversity as a result of vaccination, but should be useful as a baseline for such reductions as vaccination programs for rubella become widespread in mainland China. C1 [Zhu, Zhen; Cui, Aili; Zhang, Yan; Mao, Naiyin; Xu, Songtao; Xu, Wenbo] Natl Inst Viral Dis Control & Prevent, Minist Hlth, WHO WPRO Reg Reference Measles, Rubella Lab, Beijing, Peoples R China. [Zhu, Zhen; Cui, Aili; Zhang, Yan; Mao, Naiyin; Xu, Songtao; Xu, Wenbo] Natl Inst Viral Dis Control & Prevent, Minist Hlth, Key Lab Med Virol, Beijing, Peoples R China. [Rivailler, Pierre; Abernathy, Emily; Icenogle, Joseph] Ctr Dis Control & Prevent, Atlanta, GA USA. [Zhou, Shujie] Anhui Prov Ctr Dis Control & Prevent, Hefei, Peoples R China. [Lei, Yue] Tianjin Prov Ctr Dis Control & Prevent, Tianjin, Peoples R China. [Wang, Yan] Liaoning Prov Ctr Dis Control & Prevent, Dalian, Peoples R China. [Zheng, Huanying] Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China. [He, Jilan] Sichuan Prov Ctr Dis Control & Prevent, Chengdu, Peoples R China. [Chen, Ying] Gansu Prov Ctr Dis Control & Prevent, Lanzhou, Peoples R China. [Li, Chongshan] Shanghai Prov Ctr Dis Control & Prevent, Shanghai, Peoples R China. [Bo, Fang] Heilongjiang Prov Ctr Dis Control & Prevent, Heilongjiang, Peoples R China. [Zhao, Chunfang] Chongqing Prov Ctr Dis Control & Prevent, Chongqing, Peoples R China. [Chen, Meng] Beijing Prov Ctr Dis Control & Prevent, Beijing, Peoples R China. [Lu, Peishan] Jiangsu Prov Ctr Dis Control & Prevent, Nanjing, Jiangsu, Peoples R China. [Li, Fangcai] Hunan Prov Ctr Dis Control & Prevent, Changsha, Hunan, Peoples R China. [Gu, Suyi] Neimeng Prov Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China. [Gao, Hui] Shanxi Prov Ctr Dis Control & Prevent, Taiyuan, Peoples R China. [Guo, Yu] Hebei Prov Ctr Dis Control & Prevent, Shijiazhuang, Peoples R China. [Chen, Hui] Ningxia Prov Ctr Dis Control & Prevent, Yinchuan, Peoples R China. [Feng, Daxing] Henan Prov Ctr Dis Control & Prevent, Zhengzhou, Peoples R China. [Wang, Shuang] Jilin Prov Ctr Dis Control & Prevent, Changchun, Peoples R China. [Tang, Xiaomin] Guizhou Prov Ctr Dis Control & Prevent, Guiyang, Peoples R China. [Lei, Yake] Hubei Prov Ctr Dis Control & Prevent, Zhengzhou, Peoples R China. [Feng, Yan] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China. [Deng, Lili] Guangxi Prov Ctr Dis Control & Prevent, Guiyang, Peoples R China. [Gong, Tian] Jiangxi Prov Ctr Dis Control & Prevent, Nanchang, Peoples R China. [Fan, Lixia] Qinghai Prov Ctr Dis Control & Prevent, Qinghai, Peoples R China. RP Xu, WB (reprint author), Natl Inst Viral Dis Control & Prevent, Minist Hlth, WHO WPRO Reg Reference Measles, Rubella Lab, Beijing, Peoples R China. EM wenbo_xu1@aliyun.com; jci1@cdc.gov FU National Natural Science Foundation of China [81101244]; Key Technologies R&D Program of National Ministry of Science [2013ZX10004-202, 2012ZX10004201-003, 2012ZX10004215, 2011ZX10004-001]; National Science and Technology Major Project for Creation of Major New Drugs [2013ZX09304101]; WHO Measles Regional Reference Laboratory Funding [WPCHN1002802] FX We thank the provincial and prefectural measles and rubella laboratory staffs and the epidemiologists in mainland China for providing clinical specimens, isolates, and epidemiologic data. This work is supported by the National Natural Science Foundation of China (project no. 81101244), Key Technologies R&D Program of National Ministry of Science (2013ZX10004-202, 2012ZX10004201-003, 2012ZX10004215, and 2011ZX10004-001), National Science and Technology Major Project for Creation of Major New Drugs (2013ZX09304101), and WHO Measles Regional Reference Laboratory Funding (WPCHN1002802). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the U.S. Department of Health and Human Services. NR 32 TC 5 Z9 7 U1 1 U2 3 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD JAN 23 PY 2015 VL 5 AR 7999 DI 10.1038/srep07999 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AZ5WA UT WOS:000348287600001 PM 25613734 ER PT J AU Calvert, GM Rodriguez, L Prado, JB AF Calvert, Geoffrey M. Rodriguez, Luis Prado, Joanne Bonnar TI Worker Illness Related to Newly Marketed Pesticides - Douglas County, Washington, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Calvert, Geoffrey M.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, CDC, Washington, DC 20201 USA. [Rodriguez, Luis; Prado, Joanne Bonnar] Washington State Dept Hlth, Washington, DC USA. RP Calvert, GM (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, CDC, Washington, DC 20201 USA. EM jac6@cdc.gov NR 7 TC 3 Z9 3 U1 0 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 23 PY 2015 VL 64 IS 2 BP 42 EP 44 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ5NU UT WOS:000348268300002 PM 25611169 ER PT J AU Ailes, EC Dawson, AL Lind, JN Gilboa, SM Frey, MT Broussard, CS Honein, MA AF Ailes, Elizabeth C. Dawson, April L. Lind, Jennifer N. Gilboa, Suzanne M. Frey, Meghan T. Broussard, Cheryl S. Honein, Margaret A. TI Opioid Prescription Claims Among Women of Reproductive Age - United States, 2008-2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID PREGNANCY; PAIN C1 [Ailes, Elizabeth C.; Dawson, April L.; Lind, Jennifer N.; Gilboa, Suzanne M.; Frey, Meghan T.; Broussard, Cheryl S.; Honein, Margaret A.] CDC, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Lind, JN (reprint author), CDC, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. EM jlind@cdc.gov NR 10 TC 5 Z9 5 U1 1 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 23 PY 2015 VL 64 IS 2 BP COVER1 EP 41 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ5NU UT WOS:000348268300001 ER PT J AU Ren, ZP Wang, DQ Hwang, J Bennett, A Sturrock, HJW Ma, AM Huang, JX Xia, ZG Feng, XY Wang, JF AF Ren, Zhoupeng Wang, Duoquan Hwang, Jimee Bennett, Adam Sturrock, Hugh J. W. Ma, Aimin Huang, Jixia Xia, Zhigui Feng, Xinyu Wang, Jinfeng TI Spatial-Temporal Variation and Primary Ecological Drivers of Anopheles sinensis Human Biting Rates in Malaria Epidemic-Prone Regions of China SO PLOS ONE LA English DT Article ID INSECTICIDE-TREATED NETS; SUB-SAHARAN AFRICA; INFORMATION-SYSTEMS; MULTILEVEL ANALYSIS; TRANSMISSION; VECTORS; MANAGEMENT; GAMBIAE; MODEL; KENYA AB Background Robust malaria vector surveillance is essential for optimally selecting and targeting vector control measures. Sixty-two vector surveillance sites were established between 2005 and 2008 by the national malaria surveillance program in China to measure Anopheles sinensis human biting rates. Using these data to determine the primary ecological drivers of malaria vector human biting rates in malaria epidemic-prone regions of China will allow better targeting of vector control resources in space and time as the country aims to eliminate malaria. Methods We analyzed data from 62 malaria surveillance sentinel sites from 2005 to 2008. Linear mixed effects models were used to identify the primary ecological drivers for Anopheles sinensis human biting rates as well as to explore the spatial-temporal variation of relevant factors at surveillance sites throughout China. Results Minimum semimonthly temperature (beta = 2.99; 95% confidence interval (CI) 2.07-3.92), enhanced vegetation index (beta = 1.07; 95% CI 0.11-2.03), and paddy index (the percentage of rice paddy field in the total cultivated land area of each site) (beta = 0.86; 95% CI 0.17-1.56) were associated with greater An. Sinensis human biting rates, while increasing distance to the nearest river was associated with lower An. Sinensis human biting rates (beta = -1.47; 95% CI -2.88, -0.06). The temporal variation (sigma(2)(t0) = 1: 35) in biting rates was much larger than the spatial variation (sigma(2)(s0) = 0: 83), with 19.3% of temporal variation attributable to differences in minimum temperature and enhanced vegetation index and 16.9% of spatial variance due to distance to the nearest river and the paddy index. Discussion Substantial spatial-temporal variation in An. Sinensis human biting rates exists in malaria epidemic-prone regions of China, with minimum temperature and enhanced vegetation index accounting for the greatest proportion of temporal variation and distance to nearest river and paddy index accounting for the greatest proportion of spatial variation amongst observed ecological drivers. Conclusions Targeted vector control measures based on these findings can support the ongoing malaria elimination efforts in China more effectively. C1 [Ren, Zhoupeng; Ma, Aimin; Huang, Jixia; Wang, Jinfeng] Chinese Acad Sci, Inst Geog Sci & Nat Resource Res, State Key Lab Resources & Environm Informat Syst, Beijing, Peoples R China. [Ren, Zhoupeng] Univ Chinese Acad Sci, Beijing, Peoples R China. [Ren, Zhoupeng; Ma, Aimin; Huang, Jixia; Wang, Jinfeng] Chinese Ctr Dis Control & Prevent, Key Lab Surveillance & Early Warning Infect Dis, Beijing, Peoples R China. [Wang, Duoquan; Xia, Zhigui; Feng, Xinyu] Chinese Ctr Dis Control & Prevent, Natl Inst Parasit Dis, WHO Collaborating Ctr Malaria Schistosomiasis & F, Key Lab Parasite & Vector Biol,Minist Hlth, Shanghai, Peoples R China. [Hwang, Jimee; Bennett, Adam; Sturrock, Hugh J. W.] Univ Calif San Francisco, Global Hlth Grp, San Francisco, CA 94143 USA. [Hwang, Jimee] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA USA. [Ma, Aimin] China Univ Min & Technol, Coll Geosci & Surveying Engn, Beijing, Peoples R China. [Huang, Jixia] Beijing Forestry Univ, Ctr Technol & Mapping 3S, Beijing, Peoples R China. RP Wang, JF (reprint author), Chinese Acad Sci, Inst Geog Sci & Nat Resource Res, State Key Lab Resources & Environm Informat Syst, Beijing, Peoples R China. EM duoquan2006@hotmail.com; wangjf@Lreis.ac.cn FU National S & T Major Program [2012ZX10004-220, 2012CB955503, 2012 ZX10004-201] FX This study was supported by the National S & T Major Program (Grant No. 2012ZX10004-220, 2012CB955503 and 2012 ZX10004-201). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 57 TC 4 Z9 5 U1 2 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 22 PY 2015 VL 10 IS 1 AR e0116932 DI 10.1371/journal.pone.0116932 PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AZ9UU UT WOS:000348562900027 PM 25611483 ER PT J AU Tamiru, A Boulanger, L Chang, MA Malone, JL Aidoo, M AF Tamiru, Afework Boulanger, Lucy Chang, Michelle A. Malone, Joseph L. Aidoo, Michael TI Field assessment of dried Plasmodium falciparum samples for malaria rapid diagnostic test quality control and proficiency testing in Ethiopia SO MALARIA JOURNAL LA English DT Article DE Malaria; Quality control; Rapid Test; Proficiency testing; Ethiopia ID RURAL TANZANIA; HEALTH CENTERS; MICROSCOPY; ASSURANCE; UGANDA; ZAMBIA AB Background: Rapid diagnostic tests (RDTs) are now widely used for laboratory confirmation of suspected malaria cases to comply with the World Health Organization recommendation for universal testing before treatment. However, many malaria programmes lack quality control (QC) processes to assess RDT use under field conditions. Prior research showed the feasibility of using the dried tube specimen (DTS) method for preserving Plasmodium falciparum parasites for use as QC samples for RDTs. This study focused on the use of DTS for RDT QC and proficiency testing under field conditions. Methods: DTS were prepared using cultured P. falciparum at densities of 500 and 1,000 parasites/mu L; 50 mu L aliquots of these along with parasite negative human blood controls (0 parasites/mu L) were air-dried in specimen tubes and reactivity verified after rehydration. The DTS were used in a field study in the Oromia Region of Ethiopia. Replicate DTS samples containing 0, 500 and 1,000 parasites/mu L were stored at 4 degrees C at a reference laboratory and at ambient temperatures at two nearby health facilities. At weeks 0, 4, 8, 12, 16, 20, and 24, the DTS were rehydrated and tested on RDTs stored under manufacturer-recommended temperatures at the RL and on RDTs stored under site-specific conditions at the two health facilities. Reactivity of DTS stored at 4 degrees C at the reference laboratory on RDTs stored at the reference laboratory was considered the gold standard for assessing DTS stability. A proficiency-testing panel consisting of one negative and three positive samples, monitored with a checklist was administered at weeks 12 and 24. Results: At all the seven time points, DTS stored at both the reference laboratory and health facility were reactive on RDTs stored under the recommended temperature and under field conditions, and the DTS without malaria parasites were negative. At the reference laboratory and one health facility, a 500 parasites/mu L DTS from the proficiency panel was falsely reported as negative at week 24 due to errors in interpreting faint test lines. Conclusions: The DTS method can be used under field conditions to supplement other RDT QC methods and health worker proficiency in Ethiopia and possibly other malaria-endemic countries. C1 [Tamiru, Afework] Nekemte Reg Publ Hlth Lab, Oromia Reg Hlth Bur, Addis Ababa, Oromia, Ethiopia. [Tamiru, Afework; Boulanger, Lucy] Ethiopia Field Epidemiol Training Programme, Addis Ababa, Ethiopia. [Chang, Michelle A.; Malone, Joseph L.; Aidoo, Michael] Presidents Malaria Initiat, Ctr Dis Control & Prevent CDC, Atlanta, GA 30333 USA. RP Aidoo, M (reprint author), Presidents Malaria Initiat, Ctr Dis Control & Prevent CDC, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM maidoo@cdc.gov OI Malone, Joseph/0000-0002-5515-6171 FU President's Malaria Initiative-CDC-Ethiopia FX We thank The President's Malaria Initiative-CDC-Ethiopia (www.pmi.gov) for financial assistance to realize this work and Ethiopian Public Health Association (EPHA) for facilitating the project. NR 24 TC 1 Z9 1 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JAN 21 PY 2015 VL 14 AR 11 DI 10.1186/s12936-014-0524-z PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CB7GN UT WOS:000349795000001 PM 25605222 ER PT J AU Abdallah, JF Okoth, SA Fontecha, GA Torres, REM Banegas, EI Matute, ML Bucheli, STM Goldman, IF de Oliveira, AM Barnwell, JW Udhayakumar, V AF Abdallah, Joseph F. Okoth, Sheila Akinyi Fontecha, Gustavo A. Mejia Torres, Rosa Elena Banegas, Engels I. Luisa Matute, Maria Mancero Bucheli, Sandra Tamara Goldman, Ira F. de Oliveira, Alexandre Macedo Barnwell, John W. Udhayakumar, Venkatachalam TI Prevalence of pfhrp2 and pfhrp3 gene deletions in Puerto Lempira, Honduras SO MALARIA JOURNAL LA English DT Article DE Plasmodium falciparum; Histidine-rich protein; Rapid diagnostic tests; Microsatellites; Honduras ID RAPID DIAGNOSTIC-TESTS; PARASITE PLASMODIUM-FALCIPARUM; MULTILOCUS GENOTYPE DATA; MICROSATELLITE MARKERS; MALARIA; POPULATION; CHLOROQUINE; RESISTANCE; INFERENCE; REGION AB Background: Recent studies have demonstrated the deletion of the histidine-rich protein 2 (PfHRP2) gene (pfhrp2) in field isolates of Plasmodium falciparum, which could result in false negative test results when PfHRP2-based rapid diagnostic tests (RDTs) are used for malaria diagnosis. Although primary diagnosis of malaria in Honduras is determined based on microscopy, RDTs may be useful in remote areas. In this study, it was investigated whether there are deletions of the pfhrp2, pfhrp3 and their respective flanking genes in 68 P. falciparum parasite isolates collected from the city of Puerto Lempira, Honduras. In addition, further investigation considered the possible correlation between parasite population structure and the distribution of these gene deletions by genotyping seven neutral microsatellites. Methods: Sixty-eight samples used in this study, which were obtained from a previous chloroquine efficacy study, were utilized in the analysis. All samples were genotyped for pfhrp2, pfhrp3 and flanking genes by PCR. The samples were then genotyped for seven neutral microsatellites in order to determine the parasite population structure in Puerto Lempira at the time of sample collection. Results: It was found that all samples were positive for pfhrp2 and its flanking genes on chromosome 8. However, only 50% of the samples were positive for pfhrp3 and its neighboring genes while the rest were either pfhrp3-negative only or had deleted a combination of pfhrp3 and its neighbouring genes on chromosome 13. Population structure analysis predicted that there are at least two distinct parasite population clusters in this sample population. It was also determined that a greater proportion of parasites with pfhrp3-(and flanking gene) deletions belonged to one cluster compared to the other. Conclusion: The findings indicate that the P. falciparum parasite population in the municipality of Puerto Lempira maintains the pfhrp2 gene and that PfHRP2-based RDTs could be considered for use in this region; however continued monitoring of parasite population will be useful to detect any parasites with deletions of pfhrp2. C1 [Abdallah, Joseph F.; Okoth, Sheila Akinyi; Goldman, Ira F.; de Oliveira, Alexandre Macedo; Barnwell, John W.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. [Abdallah, Joseph F.] IHRC Inc, Atlanta, GA USA. [Okoth, Sheila Akinyi] Atlanta Res & Educ Fdn, Decatur, GA USA. [Fontecha, Gustavo A.] Natl Autonomous Univ Honduras, Microbiol Res Inst, Tegucigalpa, Honduras. [Mejia Torres, Rosa Elena; Mancero Bucheli, Sandra Tamara] Pan Amer Hlth Org, Tegucigalpa, Honduras. [Banegas, Engels I.] Minist Hlth, Natl Dept Surveillance, Natl Malaria Lab, Tegucigalpa, Honduras. [Luisa Matute, Maria] Minist Hlth, Dept Hlth Promot, Natl Malaria Program, Tegucigalpa, Honduras. RP Udhayakumar, V (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, 1600 Clifton Rd,MS D-67, Atlanta, GA 30333 USA. EM vxu0@cdc.gov FU American Society for Microbiology/CDC Postdoctoral Fellowship; Atlanta Research and Education Foundation (AREF); U.S. Agency for International Development; Amazon Malaria Initiative FX We thank members of the study team in Honduras who contributed to the collection of samples and study participants for their permission to use these samples. We acknowledge the support of the Amazon Malaria Initiative, which is supported by the U.S. Agency for International Development. We thank the Pan American Health Organization and Dr. Prabhjot Singh for facilitating this collaboration. SAO was supported by the American Society for Microbiology/CDC Postdoctoral Fellowship. SAO was also supported in part by the Atlanta Research and Education Foundation (AREF). The use of trade names and names of commercial sources is for identification purposes only and does not imply endorsement by the Centers for Disease Control and Prevention or the U.S. Department of Health and Human Services. The findings and conclusions in this presentation are those of the authors and do not necessarily represent those of the Centers for Disease Control and Prevention. NR 27 TC 5 Z9 6 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JAN 21 PY 2015 VL 14 AR 19 DI 10.1186/s12936-014-0537-7 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CA4LP UT WOS:000348875900005 PM 25604310 ER PT J AU Zemtsova, GE Montgomery, M Levin, ML AF Zemtsova, Galina E. Montgomery, Merrill Levin, Michael L. TI Relative Sensitivity of Conventional and Real-Time PCR Assays for Detection of SFG Rickettsia in Blood and Tissue Samples from Laboratory Animals SO PLOS ONE LA English DT Article ID FEVER GROUP RICKETTSIAE; SPOTTED-FEVER; IDENTIFICATION; TICKS; GENE; DNA; DIFFERENTIATION; AMBLYOMMII; INFECTION AB Studies on the natural transmission cycles of zoonotic pathogens and the reservoir competence of vertebrate hosts require methods for reliable diagnosis of infection in wild and laboratory animals. Several PCR-based applications have been developed for detection of infections caused by Spotted Fever group Rickettsiaspp. in a variety of animal tissues. These assays are being widely used by researchers, but they differ in their sensitivity and reliability. We compared the sensitivity of five previously published conventional PCR assays and one SYBR green-based real-time PCR assay for the detection of rickettsial DNA in blood and tissue samples from Rickettsia-infected laboratory animals (n = 87). The realtime PCR, which detected rickettsial DNA in 37.9% of samples, was the most sensitive. The next best were the semi-nested ompA assay and rpoB conventional PCR, which detected as positive 18.4% and 14.9% samples respectively. Conventional assays targeting ompB, gltA and hrtA genes have been the least sensitive. Therefore, we recommend the SYBR green-based real-time PCR as a tool for the detection of rickettsial DNA in animal samples due to its higher sensitivity when compared to more traditional assays. C1 [Zemtsova, Galina E.; Montgomery, Merrill; Levin, Michael L.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. RP Zemtsova, GE (reprint author), Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. EM GZemtsova@cdc.gov FU United States Federal agency Centers for Disease Control FX The study was funded by United States Federal agency Centers for Disease Control. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 17 TC 4 Z9 4 U1 0 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 21 PY 2015 VL 10 IS 1 AR e0116658 DI 10.1371/journal.pone.0116658 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AZ4PR UT WOS:000348205300030 PM 25607846 ER PT J AU Boulet, SL Mehta, A Kissin, DM Warner, L Kawwass, JF Jamieson, DJ AF Boulet, Sheree L. Mehta, Akanksha Kissin, Dmitry M. Warner, Lee Kawwass, Jennifer F. Jamieson, Denise J. TI Trends in Use of and Reproductive Outcomes Associated With Intracytoplasmic Sperm Injection SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID MALE-FACTOR INFERTILITY; IN-VITRO FERTILIZATION; TECHNOLOGIES; PREGNANCIES; COHORT; ICSI AB IMPORTANCE Intracytoplasmic sperm injection (ICSI) is increasingly used in patients without severe male factor infertility without clear evidence of a benefit over conventional in vitro fertilization (IVF). OBJECTIVE To assess national trends and reproductive outcomes for fresh IVF cycles (embryos transferred without being frozen) following the use of ICSI compared with conventional IVF with respect to clinical indications for ICSI use. DESIGN, SETTING, AND POPULATION Retrospective cohort study using data on fresh IVF and ICSI cycles reported to the US National Assisted Reproductive Technology Surveillance System during 1996-2012. MAIN OUTCOMES AND MEASURES Trends in ICSI use during 1996-2012 with respect to male factor infertility, unexplained infertility, maternal age 38 years or older, low oocyte yield, and 2 or more prior assisted reproductive technology cycles; reproductive outcomes for conventional IVF and ICSI cycles during 2008-2012, stratified by the presence or absence of male factor infertility. RESULTS Of the 1 395 634 fresh IVF cycles from 1996 through 2012, 908 767 (65.1%) used ICSI and 499 135 (35.8%) reported male factor infertility. Among cycles with male factor infertility, ICSI use increased from 76.3%(10 876/14 259) to 93.3%(32 191/34 506) (P < .001) during 1996-2012; for those without male factor infertility, ICSI use increased from 15.4%(4197/27 191) to 66.9%(42 321/63 250) (P < .001). During 2008-2012, male factor infertility was reported for 35.7%(176 911/494 907) of fresh cycles. Among those cycles, ICSI use was associated with a lower multiple birth rate compared with conventional IVF (30.9% vs 34.2%; adjusted relative risk [RR], 0.87; 95% CI, 0.83-0.91). Among cycles without male factor infertility (n = 317 996), ICSI use was associated with lower rates of implantation (23.0% vs 25.2%; adjusted RR, 0.93; 95% CI, 0.91-0.95), live birth (36.5% vs 39.2%; adjusted RR, 0.95; 95% CI, 0.93-0.97), and multiple live birth (30.1% vs 31.0%; adjusted RR, 0.93; 95% CI, 0.91-0.95) vs conventional IVF. CONCLUSIONS AND RELEVANCE Among fresh IVF cycles in the United States, ICSI use increased from 36.4% in 1996 to 76.2% in 2012, with the largest relative increase among cycles without male factor infertility. Compared with conventional IVF, ICSI use was not associated with improved postfertilization reproductive outcomes, irrespective of male factor infertility diagnosis. C1 [Boulet, Sheree L.; Mehta, Akanksha; Kissin, Dmitry M.; Warner, Lee; Kawwass, Jennifer F.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Mehta, Akanksha] Emory Univ, Sch Med, Dept Urol, Atlanta, GA USA. [Kissin, Dmitry M.; Kawwass, Jennifer F.; Jamieson, Denise J.] Emory Univ, Sch Med, Dept Obstet & Gynecol, Atlanta, GA USA. RP Boulet, SL (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,MS K34, Atlanta, GA 30341 USA. EM sbu1@cdc.gov FU National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR000454] FX This study was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under award UL1TR000454 (Dr Mehta). NR 20 TC 28 Z9 29 U1 0 U2 10 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 20 PY 2015 VL 313 IS 3 BP 255 EP 263 DI 10.1001/jama.2014.17985 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA AZ3RS UT WOS:000348145000017 PM 25602996 ER PT J AU Johns, LE Ferguson, KK Soldin, OP Cantonwine, DE Rivera-Gonzalez, LO Del Toro, LVA Calafat, AM Ye, XY Alshawabkeh, AN Cordero, JF Meeker, JD AF Johns, Lauren E. Ferguson, Kelly K. Soldin, Offie P. Cantonwine, David E. Rivera-Gonzalez, Luis O. Del Toro, Liza V. Anzalota Calafat, Antonia M. Ye, Xiaoyun Alshawabkeh, Akram N. Cordero, Jose F. Meeker, John D. TI Urinary phthalate metabolites in relation to maternal serum thyroid and sex hormone levels during pregnancy: a longitudinal analysis SO REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY LA English DT Article DE Biomarkers; Endocrine disruption; Epidemiology; Thyroid; Hormones; Urinary metabolites; Pregnancy; Phthalates ID TANDEM MASS-SPECTROMETRY; ENDOCRINE-DISRUPTING CHEMICALS; DI-(2-ETHYLHEXYL) PHTHALATE; FREE-THYROXINE; DI(2-ETHYLHEXYL) PHTHALATE; ENVIRONMENTAL CHEMICALS; HUMAN EXPOSURE; CYCLING RATS; WOMEN; HEALTH C1 [Johns, Lauren E.; Ferguson, Kelly K.; Rivera-Gonzalez, Luis O.; Meeker, John D.] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA. [Soldin, Offie P.] Georgetown Univ, Dept Med, Washington, DC USA. [Cantonwine, David E.] Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA. [Del Toro, Liza V. Anzalota; Cordero, Jose F.] Univ Puerto Rico, Grad Sch Publ Hlth, San Juan, PR 00936 USA. [Calafat, Antonia M.; Ye, Xiaoyun] Ctr Dis & Control & Prevent, Atlanta, GA USA. [Alshawabkeh, Akram N.] Northeastern Univ, Coll Engn, Boston, MA USA. RP Meeker, JD (reprint author), Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA. EM meekerj@umich.edu NR 79 TC 8 Z9 8 U1 4 U2 18 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1477-7827 J9 REPROD BIOL ENDOCRIN JI Reprod. Biol. Endocrinol. PD JAN 17 PY 2015 VL 13 PG 12 WC Endocrinology & Metabolism; Reproductive Biology SC Endocrinology & Metabolism; Reproductive Biology GA AZ8WS UT WOS:000348493000001 ER PT J AU Kovacs, SD Mullholland, K Bosch, J Campbell, H Forouzanfar, MH Khalil, I Lim, S Liu, L Maley, SN Mathers, CD Matheson, A Mokdad, AH O'Brien, K Parashar, U Schaafsma, TT Steele, D Hawes, SE Grove, JT AF Kovacs, Stephanie D. Mullholland, Kim Bosch, Julia Campbell, Harry Forouzanfar, Mohammad H. Khalil, Ibrahim Lim, Stephen Liu, Li Maley, Stephen N. Mathers, Colin D. Matheson, Alastair Mokdad, Ali H. O'Brien, Kate Parashar, Umesh Schaafsma, Torin T. Steele, Duncan Hawes, Stephen E. Grove, John T. TI Deconstructing the differences: a comparison of GBD 2010 and CHERG's approach to estimating the mortality burden of diarrhea, pneumonia, and their etiologies SO BMC INFECTIOUS DISEASES LA English DT Article ID PNEUMOCOCCAL CONJUGATE VACCINE; INFLUENZAE TYPE-B; PLACEBO-CONTROLLED-TRIAL; SYSTEMATIC ANALYSIS; GLOBAL BURDEN; RESPIRATORY-INFECTION; CHILDREN YOUNGER; NATIONAL CAUSES; DOUBLE-BLIND; DISEASE AB Background: Pneumonia and diarrhea are leading causes of death for children under five (U5). It is challenging to estimate the total number of deaths and cause-specific mortality fractions. Two major efforts, one led by the Institute for Health Metrics and Evaluation (IHME) and the other led by the World Health Organization (WHO)/Child Health Epidemiology Reference Group (CHERG) created estimates for the burden of disease due to these two syndromes, yet their estimates differed greatly for 2010. Methods: This paper discusses three main drivers of the differences: data sources, data processing, and covariates used for modelling. The paper discusses differences in the model assumptions for etiology-specific estimates and presents recommendations for improving future models. Results: IHME's Global Burden of Disease (GBD) 2010 study estimated 6.8 million U5 deaths compared to 7.6 million U5 deaths from CHERG. The proportional differences between the pneumonia and diarrhea burden estimates from the two groups are much larger; GBD 2010 estimated 0.847 million and CHERG estimated 1.396 million due to pneumonia. Compared to CHERG, GBD 2010 used broader inclusion criteria for verbal autopsy and vital registration data. GBD 2010 and CHERG used different data processing procedures and therefore attributed the causes of neonatal death differently. The major difference in pneumonia etiologies modeling approach was the inclusion of observational study data; GBD 2010 included observational studies. CHERG relied on vaccine efficacy studies. Discussion: Greater transparency in modeling methods and more timely access to data sources are needed. In October 2013, the Bill & Melinda Gates Foundation (BMGF) hosted an expert meeting to examine possible approaches for better estimation. The group recommended examining the impact of data by systematically excluding sources in their models. GBD 2.0 will use a counterfactual approach for estimating mortality from pathogens due to specific etiologies to overcome bias of the methods used in GBD 2010 going forward. C1 [Kovacs, Stephanie D.; Maley, Stephen N.; Matheson, Alastair; Schaafsma, Torin T.; Hawes, Stephen E.] Univ Washington, Strateg Anal Res & Training Program, Seattle, WA 98195 USA. [Mullholland, Kim] London Sch Hyg & Trop Med, Melbourne, Vic, Australia. [Mullholland, Kim] Murdoch Childrens Res Inst, Melbourne, Vic, Australia. [Mullholland, Kim] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT 0909, Australia. [Bosch, Julia; Khalil, Ibrahim; Steele, Duncan; Grove, John T.] Bill & Melinda Gates Fdn, Seattle, WA 98109 USA. [Campbell, Harry] Univ Edinburgh, Edinburgh, Midlothian, Scotland. [Forouzanfar, Mohammad H.; Lim, Stephen; Mokdad, Ali H.] Univ Washington, Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA. [Liu, Li] Johns Hopkins Bloomberg Sch Publ Hlth, Inst Int Programs, Baltimore, MD USA. [Mathers, Colin D.] WHO, Dept Hlth Stat & Informat, CH-1211 Geneva, Switzerland. [O'Brien, Kate] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Parashar, Umesh] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. RP Grove, JT (reprint author), Bill & Melinda Gates Fdn, Seattle, WA 98109 USA. EM john.grove@gatesfoundation.org FU World Health Organization [001] NR 36 TC 9 Z9 9 U1 1 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD JAN 16 PY 2015 VL 15 AR 16 DI 10.1186/s12879-014-0728-4 PG 15 WC Infectious Diseases SC Infectious Diseases GA CA4LJ UT WOS:000348875300001 PM 25592774 ER PT J AU Williams, J Mai, CT Mulinare, J Isenburg, J Flood, TJ Ethen, M Frohnert, B Kirby, RS AF Williams, Jennifer Mai, Cara T. Mulinare, Joe Isenburg, Jennifer Flood, Timothy J. Ethen, Mary Frohnert, Barbara Kirby, Russell S. TI Updated Estimates of Neural Tube Defects Prevented by Mandatory Folic Acid Fortification - United States, 1995-2011 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID POPULATION; FOLATE C1 [Williams, Jennifer; Mai, Cara T.; Mulinare, Joe; Isenburg, Jennifer] CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Flood, Timothy J.] Arizona Dept Hlth Serv, Bur Publ Hlth Stat, Phoenix, AZ 85007 USA. [Ethen, Mary] Texas Dept State Hlth Serv, Birth Defects Epidemiol & Surveillance Branch, Austin, TX USA. [Frohnert, Barbara] Minnesota Dept Hlth, Div Community & Family Hlth, Minneapolis, MN 55414 USA. [Kirby, Russell S.] Univ S Florida, Coll Publ Hlth, Tampa, FL 33620 USA. RP Williams, J (reprint author), CDC, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. EM jwilliams2@cdc.gov NR 10 TC 82 Z9 82 U1 3 U2 20 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 16 PY 2015 VL 64 IS 1 BP 1 EP 5 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ8QL UT WOS:000348479800002 PM 25590678 ER PT J AU Arth, A Tinker, S Moore, C Canfield, M Agopian, AJ Reefhuis, J AF Arth, Annelise Tinker, Sarah Moore, Cynthia Canfield, Mark Agopian, A. J. Reefhuis, Jennita TI Supplement Use and Other Characteristics Among Pregnant Women with a Previous Pregnancy Affected by a Neural Tube Defect - United States, 1997-2009 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID FOLIC-ACID SUPPLEMENTATION; RECURRENCE-PREVENTION C1 [Arth, Annelise; Tinker, Sarah; Moore, Cynthia; Reefhuis, Jennita] CDC, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Canfield, Mark] Texas Dept State Hlth Serv, Austin, TX USA. [Agopian, A. J.] Univ Texas Sch Publ Hlth, Austin, TX USA. RP Arth, A (reprint author), CDC, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. EM aarth@cdc.gov NR 10 TC 4 Z9 4 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 16 PY 2015 VL 64 IS 1 BP 6 EP 9 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ8QL UT WOS:000348479800003 PM 25590679 ER PT J AU Flannery, B Clippard, J Zimmerman, RK Nowalk, MP Jackson, ML Jackson, LA Monto, AS Petrie, JG McLean, HQ Belongia, EA Gaglani, M Berman, L Foust, A Sessions, W Thaker, SN Spencer, S Fry, AM AF Flannery, Brendan Clippard, Jessie Zimmerman, Richard K. Nowalk, Mary Patricia Jackson, Michael L. Jackson, Lisa A. Monto, Arnold S. Petrie, Joshua G. McLean, Huong Q. Belongia, Edward A. Gaglani, Manjusha Berman, LaShondra Foust, Angie Sessions, Wendy Thaker, Swathi N. Spencer, Sarah Fry, Alicia M. TI Early Estimates of Seasonal Influenza Vaccine Effectiveness - United States, January 2015 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID EFFICACY C1 [Flannery, Brendan; Clippard, Jessie; Berman, LaShondra; Foust, Angie; Sessions, Wendy; Thaker, Swathi N.; Spencer, Sarah; Fry, Alicia M.] CDC, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA. [Zimmerman, Richard K.; Nowalk, Mary Patricia] Univ Pittsburgh, Sch Hlth Sci, Pittsburgh, PA 15260 USA. [Zimmerman, Richard K.; Nowalk, Mary Patricia] UPMC, Pittsburgh, PA USA. [Jackson, Michael L.; Jackson, Lisa A.] Grp Hlth Res Inst, Seattle, WA USA. [Monto, Arnold S.; Petrie, Joshua G.] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA. [Gaglani, Manjusha] Texas A&M Univ, Baylor Scott & White Hlth, Hlth Sci Ctr, Coll Med, College Stn, TX 77843 USA. RP Flannery, B (reprint author), CDC, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA. EM bflannery@cdc.gov OI Zimmerman, Richard/0000-0001-5941-6092 FU NCIRD CDC HHS [U01 IP000467] NR 9 TC 88 Z9 89 U1 5 U2 27 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 16 PY 2015 VL 64 IS 1 BP 10 EP 15 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ8QL UT WOS:000348479800004 PM 25590680 ER PT J AU Nielsen, CF Kidd, S Sillah, ARM Davis, E Mermin, J Kilmarx, PH AF Nielsen, Carrie F. Kidd, Sarah Sillah, Ansumana R. M. Davis, Edward Mermin, Jonathan Kilmarx, Peter H. TI Improving Burial Practices and Cemetery Management During an Ebola Virus Disease Epidemic - Sierra Leone, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Nielsen, Carrie F.; Kilmarx, Peter H.] CDC, Ctr Global Hlth, Atlanta, GA 30333 USA. [Kidd, Sarah; Mermin, Jonathan] CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Nielsen, CF (reprint author), CDC, Ctr Global Hlth, Atlanta, GA 30333 USA. EM cnielsen@cdc.gov NR 7 TC 21 Z9 22 U1 0 U2 21 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 16 PY 2015 VL 64 IS 1 BP 20 EP 27 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ8QL UT WOS:000348479800006 PM 25590682 ER PT J AU Miller, LA Sukalac, T Stanger, E Senesi, RGB DeLuca, N Dietz, P Hausman, L Kilmarx, PH Mermin, J AF Miller, Leigh Ann Sukalac, Thomas Stanger, Emily Senesi, Reynold G. B. DeLuca, Nick Dietz, Patricia Hausman, Leslie Kilmarx, Peter H. Mermin, Jonathan TI Use of a Nationwide Call Center for Ebola Response and Monitoring During a 3-Day House-to-House Campaign - Sierra Leone, September 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Miller, Leigh Ann; Kilmarx, Peter H.] CDC, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA 30333 USA. [Sukalac, Thomas; Mermin, Jonathan] CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Stanger, Emily] Tony Blair Africa Governance Initiat, Freetown, Sierra Leone. [Senesi, Reynold G. B.] Minist Publ Hlth, Freetown, Sierra Leone. [DeLuca, Nick; Dietz, Patricia] CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div HIV AIDS, Atlanta, GA 30333 USA. [Hausman, Leslie] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Miller, LA (reprint author), CDC, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA 30333 USA. EM lamiller@cdc.gov NR 1 TC 5 Z9 5 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 16 PY 2015 VL 64 IS 1 BP 28 EP 29 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ8QL UT WOS:000348479800007 PM 25590683 ER PT J AU Painter, JE Walker, AT Pytell, J Nua, MT Soliai-Lemusu, S Mintz, E Ali, I Parsons, M Martin, H Beach, M Bowen, A Cope, J AF Painter, Julia E. Walker, Allison Taylor Pytell, Jarratt Nua, Motusa Tuileama Soliai-Lemusu, Siitia Mintz, Eric Ali, Ibne Parsons, Michele Martin, Haley Beach, Michael Bowen, Anna Cope, Jennifer TI Outbreak of DiarrheaL Illness Caused by Shigella flexneri - American Samoa, May-June 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Painter, Julia E.; Walker, Allison Taylor] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Painter, Julia E.; Walker, Allison Taylor; Pytell, Jarratt; Mintz, Eric; Ali, Ibne; Parsons, Michele; Martin, Haley; Beach, Michael; Bowen, Anna; Cope, Jennifer] CDC, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Nua, Motusa Tuileama; Soliai-Lemusu, Siitia] Amer Samoa Dept Hlth, Pago Pago, AS USA. RP Painter, JE (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM epf3@cdc.gov NR 2 TC 1 Z9 2 U1 0 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 16 PY 2015 VL 64 IS 1 BP 30 EP 30 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AZ8QL UT WOS:000348479800008 PM 25590684 ER PT J AU Moore, MC Davis, RD Kang, Q Vahl, CI Wallace, RM Hanlon, CA Mosier, DA AF Moore, Michael C. Davis, Rolan D. Kang, Qing Vahl, Christopher I. Wallace, Ryan M. Hanlon, Cathleen A. Mosier, Derek A. TI Comparison of anamnestic responses to rabies vaccination in dogs and cats with current and out-of-date vaccination status SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Article ID ANTIBODY AB Objective-To compare anamnestic antibody responses of dogs and cats with current versus out-of-date vaccination status. Design-Cross-sectional study. Animals-74 dogs and 33 cats. Procedures-Serum samples were obtained from dogs and cats that had been exposed to rabies and brought to a veterinarian for proactive serologic monitoring or that had been brought to a veterinarian for booster rabies vaccination. Blood samples were collected on the day of initial evaluation (day 0) and then again 5 to 15 days later. On day 0, a rabies vaccine was administered according to label recommendations. Paired serum samples were analyzed for antirabies antibodies by means of a rapid fluorescent focus inhibition test. Results-All animals had an antirabies antibody titer >= 0.5 IU/mL 5 to 15 days after booster vaccination. Dogs with an out-of-date vaccination status had a higher median increase in titer, higher median fold increase in titer, and higher median titer following booster vaccination, compared with dogs with current vaccination status. Most (26/33) cats, regardless of rabies vaccination status, had a titer >= 12 IU/mL 5 to 15 days after booster vaccination. Conclusions and Clinical Relevance-Results indicated that dogs with out-of-date vaccination status were not inferior in their antibody response following booster rabies vaccination, compared with dogs with current vaccination status. Findings supported immediate booster vaccination followed by observation for 45 days of dogs and cats with an out-of-date vaccination status that are exposed to rabies, as is the current practice for dogs and cats with current vaccination status. C1 [Moore, Michael C.; Davis, Rolan D.; Hanlon, Cathleen A.] Kansas State Univ, Coll Vet Med, Vet Diagnost Lab, Manhattan, KS 66506 USA. [Mosier, Derek A.] Kansas State Univ, Coll Vet Med, Dept Diagnost Med & Pathobiol, Manhattan, KS 66506 USA. [Vahl, Christopher I.] Kansas State Univ, Dept Stat, Coll Arts & Sci, Manhattan, KS 66506 USA. [Kang, Qing] Stat Intelligence Grp LLC, Manhattan, KS 66503 USA. [Wallace, Ryan M.; Hanlon, Cathleen A.] CDC, Atlanta, GA 30333 USA. RP Moore, MC (reprint author), Kansas State Univ, Coll Vet Med, Vet Diagnost Lab, Manhattan, KS 66506 USA. EM mcmoore@vet.k-state.edu NR 9 TC 3 Z9 3 U1 0 U2 5 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA SN 0003-1488 EI 1943-569X J9 JAVMA-J AM VET MED A JI JAVMA-J. Am. Vet. Med. Assoc. PD JAN 15 PY 2015 VL 246 IS 2 BP 205 EP 211 PG 7 WC Veterinary Sciences SC Veterinary Sciences GA CE8MJ UT WOS:000352096500024 PM 25554936 ER PT J AU Chesson, HW Markowitz, LE AF Chesson, Harrell W. Markowitz, Lauri E. TI The Cost-effectiveness of Human Papillomavirus Vaccine Catch-up Programs for Women SO JOURNAL OF INFECTIOUS DISEASES LA English DT Editorial Material DE human papillomavirus; vaccine; cost-effectiveness analysis; HPV; models ID HPV VACCINATION; UNITED-STATES; DEVELOPED-COUNTRIES; ECONOMIC-EVALUATION; CERVICAL-CANCER; STRATEGIES; IMPACT; MODEL C1 [Chesson, Harrell W.; Markowitz, Lauri E.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Chesson, HW (reprint author), Ctr Dis Control & Prevent, Mail Stop E-80,1600 Clifton Rd, Atlanta, GA 30333 USA. EM hchesson@cdc.gov NR 18 TC 5 Z9 5 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 15 PY 2015 VL 211 IS 2 BP 172 EP 174 DI 10.1093/infdis/jiu414 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CC3CC UT WOS:000350221000002 PM 25057043 ER PT J AU Marjuki, H Mishin, VP Chesnokov, AP Jones, J De La Cruz, JA Sleeman, K Tamura, D Nguyen, HT Wu, HS Chang, FY Liu, MT Fry, AM Cox, NJ Villanueva, JM Davis, CT Gubareva, LV AF Marjuki, Henju Mishin, Vasiliy P. Chesnokov, Anton P. Jones, Joyce De La Cruz, Juan A. Sleeman, Katrina Tamura, Daisuke Nguyen, Ha T. Wu, Ho-Sheng Chang, Feng-Yee Liu, Ming-Tsan Fry, Alicia M. Cox, Nancy J. Villanueva, Julie M. Davis, Charles T. Gubareva, Larisa V. TI Characterization of Drug-Resistant Influenza A(H7N9) Variants Isolated From an Oseltamivir-Treated Patient in Taiwan SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE influenza virus; H7N9; oseltamivir; peramivir; R292K; E119V; I222K; I222R; mice; ferrets ID NEURAMINIDASE INHIBITOR RESISTANCE; A H7N9 VIRUS; A(H1N1) VIRUSES; R292K MUTATION; ACTIVE-SITE; FERRETS; VIRULENCE; FITNESS; TRANSMISSIBILITY; SENSITIVITY AB Background. Patients contracting influenza A(H7N9) infection often developed severe disease causing respiratory failure. Neuraminidase (NA) inhibitors (NAIs) are the primary option for treatment, but information on drug-resistance markers for influenza A(H7N9) is limited. Methods. Four NA variants of A/Taiwan/1/2013(H7N9) virus containing a single substitution (NA-E119V, NA-I222K, NA-I222R, or NA-R292K) recovered from an oseltamivir-treated patient were tested for NAI susceptibility in vitro; their replicative fitness was evaluated in cell culture, mice, and ferrets. Results. NA-R292K led to highly reduced inhibition by oseltamivir and peramivir, while NA-E119V, NA-I222K, and NA-I222R caused reduced inhibition by oseltamivir. Mice infected with any virus showed severe clinical signs with high mortality rates. NA-I222K virus was the most virulent in mice, whereas virus lacking NA change (NA-WT) and NA-R292K virus seemed the least virulent. Sequence analysis suggests that PB2-S714N increased virulence of NA-I222K virus in mice; NS1-K126R, alone or in combination with PB2-V227M, produced contrasting effects in NA-WT and NA-R292K viruses. In ferrets, all viruses replicated to high titers in the upper respiratory tract but produced only mild illness. NA-R292K virus, showed reduced replicative fitness in this animal model. Conclusions. Our data highlight challenges in assessment of the replicative fitness of H7N9 NA variants that emerged in NAI-treated patients. C1 [Marjuki, Henju; Mishin, Vasiliy P.; Chesnokov, Anton P.; Jones, Joyce; De La Cruz, Juan A.; Sleeman, Katrina; Tamura, Daisuke; Nguyen, Ha T.; Fry, Alicia M.; Cox, Nancy J.; Villanueva, Julie M.; Davis, Charles T.; Gubareva, Larisa V.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Chesnokov, Anton P.; De La Cruz, Juan A.; Nguyen, Ha T.] Battelle Mem Inst, Atlanta, GA USA. [Tamura, Daisuke] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Wu, Ho-Sheng; Chang, Feng-Yee; Liu, Ming-Tsan] Taiwan Ctr Dis Control, Taipei, Taiwan. RP Gubareva, LV (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd MS G16, Atlanta, GA 30333 USA. EM lgubareva@cdc.gov FU Centers for Disease Control and Prevention (CDC) Influenza Division; Biomedical Advanced Research and Development Authority; CDC FX This work was supported by the Centers for Disease Control and Prevention (CDC) Influenza Division and by an interagency agreement between Biomedical Advanced Research and Development Authority and the CDC. NR 46 TC 22 Z9 22 U1 1 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 15 PY 2015 VL 211 IS 2 BP 249 EP 257 DI 10.1093/infdis/jiu447 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CC3CC UT WOS:000350221000012 PM 25124927 ER PT J AU Osadebe, LU Manthiram, K McCollum, AM Li, Y Emerson, GL Gallardo-Romero, NF Doty, JB Wilkins, K Zhao, H Drew, CP Metcalfe, MG Goldsmith, CS Muehlenbachs, A Googe, PB Dunn, J Duenckel, T Henderson, H Carroll, DS Zaki, SR Denison, MR Reynolds, MG Damon, IK AF Osadebe, Lynda U. Manthiram, Kalpana McCollum, Andrea M. Li, Yu Emerson, Ginny L. Gallardo-Romero, Nadia F. Doty, Jeffrey B. Wilkins, Kimberly Zhao, Hui Drew, Clifton P. Metcalfe, Maureen G. Goldsmith, Cynthia S. Muehlenbachs, Atis Googe, Paul B. Dunn, John Duenckel, Todd Henderson, Heather Carroll, Darin S. Zaki, Sherif R. Denison, Mark R. Reynolds, Mary G. Damon, Inger K. TI Novel Poxvirus Infection in 2 Patients From the United States SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE poxvirus; skin infection; parapoxvirus; immunocompromised; imiquimod ID ORF VIRUS-INFECTION; GENUS PARAPOXVIRUS; RECURRENT ORF; IMIQUIMOD; GIANT; DEER AB Background. Some human poxvirus infections can be acquired through zoonotic transmission. We report a previously unknown poxvirus infection in 2 patients, 1 of whom was immunocompromised; both patients had known equine contact. Methods. The patients were interviewed and clinical information was abstracted from the patients' medical files. Biopsies of the skin lesions were collected from both patients for histopathology, immunohistochemistry, and transmission electron microscopy analysis. Oral and skin swabs were collected from animals with frequent contact with the patients, and environmental sampling including rodent trapping was performed on the farm where the immunosuppressed patient was employed. "Pan-pox and high Guanine-cytosine" polymerase chain reaction assays were performed on patient, animal, and environmental isolates. Amplicon sequences of the viral DNA were used for agent identification and phylogenetic analysis. Results. Specimens from both human cases revealed a novel poxvirus. The agent shares 88% similarity to viruses in the Parapoxvirus genus and 78% to those in the Molluscipoxvirus genus but is sufficiently divergent to resist classification as either. All animal and environmental specimens were negative for poxvirus and both patients had complete resolution of lesions. Conclusions. This report serves as a reminder that poxviruses should be considered in cutaneous human infections, especially in individuals with known barnyard exposures. The clinical course of the patients was similar to that of parapoxvirus infections, and the source of this virus is currently unknown but is presumed to be zoonotic. This report also demonstrates the importance of a comprehensive approach to diagnosis of human infections caused by previously unknown pathogens. C1 [Osadebe, Lynda U.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Div Sci Educ & Profess Dev, Program Off, Atlanta, GA 30333 USA. [Osadebe, Lynda U.; McCollum, Andrea M.; Li, Yu; Emerson, Ginny L.; Gallardo-Romero, Nadia F.; Doty, Jeffrey B.; Wilkins, Kimberly; Zhao, Hui; Drew, Clifton P.; Metcalfe, Maureen G.; Goldsmith, Cynthia S.; Muehlenbachs, Atis; Carroll, Darin S.; Zaki, Sherif R.; Reynolds, Mary G.; Damon, Inger K.] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. [Googe, Paul B.] Vanderbilt Univ, Med Ctr, Knoxville Dermatopathol Lab, Nashville, TN USA. [Manthiram, Kalpana] Vanderbilt Univ, Med Ctr, Div Pediat Infect Dis, Nashville, TN USA. [Dunn, John; Henderson, Heather] Tennessee Dept Hlth, Nashville, TN USA. [Duenckel, Todd] US Anim & Plant Hlth Inspect Serv, USDA, Reg Off, Nashville, TN USA. RP Reynolds, MG (reprint author), Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, 1600 Clifton Rd NE,MS A30, Atlanta, GA 30333 USA. EM nzr6@cdc.gov OI Googe, Paul/0000-0002-9185-3548 NR 18 TC 5 Z9 5 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 15 PY 2015 VL 60 IS 2 BP 195 EP 202 DI 10.1093/cid/ciu790 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CB6TR UT WOS:000349760100004 PM 25301210 ER PT J AU Martin, SW Pawloski, L Williams, M Weening, K DeBolt, C Qin, X Reynolds, L Kenyon, C Giambrone, G Kudish, K Miller, L Selvage, D Lee, A Skoff, TH Kamiya, H Cassiday, PK Tondella, ML Clark, TA AF Martin, Stacey W. Pawloski, Lucia Williams, Margaret Weening, Keeley DeBolt, Chas Qin, Xuan Reynolds, Laura Kenyon, Cynthia Giambrone, Gregory Kudish, Kathy Miller, Lisa Selvage, David Lee, Adria Skoff, Tami H. Kamiya, Hajime Cassiday, Pamela K. Tondella, Maria L. Clark, Thomas A. TI Pertactin-Negative Bordetella pertussis Strains: Evidence for a Possible Selective Advantage SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE Bordetella pertussis; pertactin; acellular vaccine; waning immunity; mutations ID WHOLE-CELL; EXPRESSING PERTACTIN; GENOMIC CONTENT; UNITED-STATES; VACCINES; CHILDREN; DEFICIENT; VARIANTS; PATHOGENESIS; PROTECTION AB Background. A recent increase in Bordetella pertussis without the pertactin protein, an acellular vaccine immunogen, has been reported in the United States. Determining whether pertactin-deficient (PRN-) B. pertussis is evading vaccine-induced immunity or altering the severity of illness is needed. Methods. We retrospectively assessed for associations between pertactin production and both clinical presentation and vaccine history. Cases with isolates collected between May 2011 and February 2013 from 8 states were included. We calculated unadjusted and adjusted odds ratios (ORs) using multivariable logistic regression analysis. Results. Among 753 isolates, 640 (85%) were PRN-. The age distribution differed between cases caused by PRN- B. pertussis and cases caused by B. pertussis producing pertactin (PRN+) (P = .01). The proportion reporting individual pertussis symptoms was similar between the 2 groups, except a higher proportion of PRN+ case-patients reported apnea (P = .005). Twenty-two case-patients were hospitalized; 6% in the PRN+ group compared to 3% in the PRN-group (P = .11). Case-patients having received at least 1 pertussis vaccine dose had a higher odds of having PRN -B. pertussis compared with unvaccinated case-patients (adjusted OR = 2.2; 95% confidence interval [CI], 1.3-4.0). When restricted to case-patients at least 1 year of age and those age-appropriately vaccinated, the adjusted OR increased to 2.7 (95% CI, 1.2-6.1). Conclusions. The significant association between vaccination and isolate pertactin production suggests that the likelihood of having reported disease caused by PRN -compared with PRN+ strains is greater in vaccinated persons. Additional studies are needed to assess whether vaccine effectiveness is diminished against PRN-strains. C1 [Martin, Stacey W.; Pawloski, Lucia; Williams, Margaret; Lee, Adria; Skoff, Tami H.; Kamiya, Hajime; Cassiday, Pamela K.; Tondella, Maria L.; Clark, Thomas A.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Weening, Keeley] Vermont Dept Hlth, Burlington, VT 05402 USA. [DeBolt, Chas] Washington State Dept Hlth, Seattle, WA USA. [Qin, Xuan] Seattle Childrens Hosp, Seattle, WA USA. [Reynolds, Laura] Multnomah Cty Hlth Dept, Portland, OR USA. [Kenyon, Cynthia] Minnesota Dept Hlth, St Paul, MN USA. [Giambrone, Gregory] New York State Dept Hlth, Albany, NY 12237 USA. [Kudish, Kathy] Connecticut Dept Publ Hlth & Addict Serv, Hartford, CT 06106 USA. [Miller, Lisa] Colorado Dept Hlth & Environm, Denver, CO USA. [Selvage, David] New Mexico Dept Hlth, Santa Fe, NM USA. RP Martin, SW (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS C25, Atlanta, GA 30333 USA. EM smartin4@cdc.gov FU Centers for Disease Control and Prevention FX C. K. received grants from Centers for Disease Control and Prevention during the conduct of the study. All other authors report no potential conflicts. NR 34 TC 47 Z9 48 U1 0 U2 11 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 15 PY 2015 VL 60 IS 2 BP 223 EP 227 DI 10.1093/cid/ciu788 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CB6TR UT WOS:000349760100008 PM 25301209 ER PT J AU Doker, TJ Sharp, TM Rivera-Garcia, B Perez-Padilla, J Benoit, TJ Ellis, EM Elrod, MG Gee, JE Shieh, WJ Beesley, CA Ryff, KR Traxler, RM Galloway, RL Haberling, DL Waller, LA Shadomy, SV Bower, WA Hoffmaster, AR Walke, HT Blaney, DD AF Doker, Thomas J. Sharp, Tyler M. Rivera-Garcia, Brenda Perez-Padilla, Janice Benoit, Tina J. Ellis, Esther M. Elrod, Mindy G. Gee, Jay E. Shieh, Wun-Ju Beesley, Cari A. Ryff, Kyle R. Traxler, Rita M. Galloway, Renee L. Haberling, Dana L. Waller, Lance A. Shadomy, Sean V. Bower, William A. Hoffmaster, Alex R. Walke, Henry T. Blaney, David D. TI Contact Investigation of Melioidosis Cases Reveals Regional Endemicity in Puerto Rico SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE melioidosis; Burkholderia pseudomallei; Puerto Rico; emerging infectious disease ID BURKHOLDERIA-PSEUDOMALLEI; GLANDERS; DISEASE AB Background. Melioidosis results from infection with Burkholderia pseudomallei and is associated with case-fatality rates up to 40%. Early diagnosis and treatment with appropriate antimicrobials can improve survival rates. Fatal and nonfatal melioidosis cases were identified in Puerto Rico in 2010 and 2012, respectively, which prompted contact investigations to identify risk factors for infection and evaluate endemicity. Methods. Questionnaires were administered and serum specimens were collected from coworkers, neighborhood contacts within 250 m of both patients' residences, and injection drug user (IDU) contacts of the 2012 patient. Serum specimens were tested for evidence of prior exposure to B. pseudomallei by indirect hemagglutination assay. Neighborhood seropositivity results guided soil sampling to isolate B. pseudomallei. Results. Serum specimens were collected from contacts of the 2010 (n = 51) and 2012 (n = 60) patients, respectively. No coworkers had detectable anti-B. pseudomallei antibody, whereas seropositive results among neighborhood contacts was 5% (n = 2) for the 2010 patient and 23% (n = 12) for the 2012 patient, as well as 2 of 3 IDU contacts for the 2012 case. Factors significantly associated with seropositivity were having skin wounds, sores, or ulcers (odds ratio [OR], 4.6; 95% confidence interval [CI], 1.2-17.8) and IDU (OR, 18.0; 95% CI, 1.6-194.0). Burkholderia pseudomallei was isolated from soil collected in the neighborhood of the 2012 patient. Conclusions. Taken together, isolation of B. pseudomallei from a soil sample and high seropositivity among patient contacts suggest at least regional endemicity of melioidosis in Puerto Rico. Increased awareness of melioidosis is needed to enable early case identification and early initiation of appropriate antimicrobial therapy. C1 [Doker, Thomas J.; Ellis, Esther M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Doker, Thomas J.; Benoit, Tina J.; Elrod, Mindy G.; Gee, Jay E.; Beesley, Cari A.; Traxler, Rita M.; Galloway, Renee L.; Shadomy, Sean V.; Bower, William A.; Hoffmaster, Alex R.; Walke, Henry T.; Blaney, David D.] Ctr Dis Control & Prevent, Bacterial Special Pathogens Branch, Atlanta, GA 30333 USA. [Sharp, Tyler M.; Perez-Padilla, Janice; Ellis, Esther M.] Ctr Dis Control & Prevent, Dengue Branch, Atlanta, GA 30333 USA. [Rivera-Garcia, Brenda; Ryff, Kyle R.] Puerto Rico Dept Hlth, San Juan, PR USA. [Shieh, Wun-Ju] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA 30333 USA. [Haberling, Dana L.] Ctr Dis Control & Prevent, Prion & Publ Hlth Off, Atlanta, GA 30333 USA. [Waller, Lance A.] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA. RP Blaney, DD (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS A-30, Atlanta, GA 30333 USA. EM dblaney@cdc.gov FU Wellcome Trust FX We thank all participants for their willingness to assist in this investigation. We also thank David Noyd, Jazmin Roman Sierra, and Chanis Mercardo for assistance conducting contact investigations, Kay Tomashek and Harold Margolis for supporting the investigation, and Clifton Drew for identifying the 2010 case. This publication made use of the Multi-Locus Sequence Typing website (http://www.mlst.net) at Imperial College London developed by David Aanensen and funded by the Wellcome Trust. NR 23 TC 16 Z9 16 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 15 PY 2015 VL 60 IS 2 BP 243 EP 250 DI 10.1093/cid/ciu764 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CB6TR UT WOS:000349760100011 PM 25270646 ER PT J AU Jones, JL Bonetti, V Holland, GN Press, C Sanislo, SR Khurana, RN Montoya, JG AF Jones, Jeffrey L. Bonetti, Valerie Holland, Gary N. Press, Cindy Sanislo, Steven R. Khurana, Rahul N. Montoya, Jose G. TI Ocular Toxoplasmosis in the United States: Recent and Remote Infections SO CLINICAL INFECTIOUS DISEASES LA English DT Editorial Material DE toxoplasmosis; Toxoplasma gondii; ocular; eye ID GONDII INFECTION; DIAGNOSIS; AVIDITY AB We tested all samples from patients with ocular toxoplasmosis sent to the Palo Alto Medical Foundation Toxoplasma Reference Laboratory from June 2004 through August 2010 for serologic evidence of recent Toxoplasma gondii infection. Of 205 patients aged 10-96 years, 11.7% had recent infection. Many people develop ocular disease soon after T. gondii infection. C1 [Jones, Jeffrey L.] Ctr Dis Control & Prevent, Parasit Dis Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30329 USA. [Bonetti, Valerie; Press, Cindy; Montoya, Jose G.] Palo Alto Med Fdn, Toxoplasma Serol Lab, Palo Alto, CA USA. [Holland, Gary N.] Univ Calif Los Angeles, Jules Stein Eye Inst, Ocular Inflammatory Dis Ctr, Los Angeles, CA 90024 USA. [Holland, Gary N.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Ophthalmol, Los Angeles, CA 90095 USA. [Sanislo, Steven R.] Stanford Univ, Sch Med, Byers Eye Inst, Stanford, CA 94305 USA. [Khurana, Rahul N.] Northern Calif Retina Vitreous Associates, Mountain View, CA USA. [Montoya, Jose G.] Stanford Univ, Sch Med, Dept Med, Div Infect Dis & Geog Med, Stanford, CA 94305 USA. RP Jones, JL (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30329 USA. EM jlj1@cdc.gov NR 15 TC 4 Z9 4 U1 1 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 15 PY 2015 VL 60 IS 2 BP 271 EP 273 DI 10.1093/cid/ciu793 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CB6TR UT WOS:000349760100016 PM 25301214 ER PT J AU Moro, PL Zheteyeva, Y Lewis, P Shi, J Yue, X Museru, OI Broder, K AF Moro, Pedro L. Zheteyeva, Yenlik Lewis, Paige Shi, Jing Yue, Xin Museru, Oidda I. Broder, Karen TI Safety of quadrivalent human papillomavirus vaccine (Gardasil (R)) in pregnancy: Adverse events among non-manufacturer reports in the Vaccine Adverse Event Reporting System, 2006-2013 SO VACCINE LA English DT Article DE Adverse events; Epidemiology; Quadrivalent human papillomavirus vaccine; Pregnancy; Surveillance; Vaccine safety ID IMMUNIZATION; OUTCOMES; DISEASE AB Background: In 2006, quadrivalent human papillomavirus (HPV4; Gardasil, Merck & Co., Inc.) vaccine was licensed in the US for use in females aged 9-26 years. HPV4 is not recommended during pregnancy; however, inadvertent administration during pregnancy may occur. Objectives: To evaluate and summarize reports to the Vaccine Adverse Event Reporting System (VAERS) in pregnant women who received HPV4 vaccine and assess for potentially concerning adverse events among non-manufacturer reports. Methods: We searched the VAERS database for non-manufacturer reports of adverse events (AEs) in pregnant women who received HPV4 vaccine from 6/1/2006 to 12/31/2013. We conducted clinical review of reports and available medical records. Results: We found 147 reports after HPV4 vaccine administered to pregnant women. The most frequent pregnancy-specific AE was spontaneous abortion in 15 (10.2%) reports, followed by elective terminations in 6 (4.1%). Maternal fever was the most frequent non-pregnancy-specific AE in 3 reports. Two reports of major birth defects were received. No maternal deaths were noted. One hundred-three (70.1%) reports did not describe an AE. Conclusions: This review of VAERS non-manufacturer reports following vaccination with HPV4 in pregnancy did not find any unexpected patterns in maternal or fetal outcomes. Published by Elsevier Ltd. C1 [Moro, Pedro L.; Lewis, Paige; Museru, Oidda I.; Broder, Karen] Ctrs Dis Control & Prevent CDC, Immunizat Safety Off, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Zheteyeva, Yenlik] Ctrs Dis Control & Prevent CDC, Community Intervent Infect Control Unit, Div Global Migrat & Quarantine, Atlanta, GA USA. [Shi, Jing] CDC, HIV Incidence & Case Surveillance Branch, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Yue, Xin] CDC, Assessment Branch, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Moro, PL (reprint author), Ctr Dis Control & Prevent, Immunizat Safety Off, Div Healthcare Qual Promot, 1600 Clifton Rd,MS 026, Atlanta, GA 30333 USA. EM psm9@cdc.gov FU Centers for Disease Control and Prevention (CDC) and Food and Drug Administration (FDA) FX We thank Drs. Frank DeStefano and Claudia Vellozzi for their helpful comments and advice. We also thank Dr. Janet Cragan from the Division of Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention (CDC) for her valuable expert advice. This study was funded by the Centers for Disease Control and Prevention (CDC) and Food and Drug Administration (FDA). NR 19 TC 7 Z9 8 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 15 PY 2015 VL 33 IS 4 BP 519 EP 522 DI 10.1016/j.vaccine.2014.11.047 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA CA8UJ UT WOS:000349196100006 PM 25500173 ER PT J AU Bodager, JR Parsons, MB Wright, PC Rasambainarivo, F Roellig, D Xiao, LH Gillespie, TR AF Bodager, Jonathan R. Parsons, Michele B. Wright, Patricia C. Rasambainarivo, Fidisoa Roellig, Dawn Xiao, Lihua Gillespie, Thomas R. TI Complex epidemiology and zoonotic potential for Cryptosporidium suis in rural Madagascar SO VETERINARY PARASITOLOGY LA English DT Article DE Africa; Cryptosporidium; Diarrheal disease; Water-borne disease; Zoonosis ID IDENTIFICATION; CHILDREN AB Cryptosporidium spp. is the most important parasitic diarrheal agent in the world, is among the top four causes of moderate-to-severe diarrheal disease in young children in developing nations, and is problematic as an opportunistic co-infection with HIV. In addition, Cryptosporidium is a persistent challenge for livestock production. Despite its zoonotic potential, few studies have examined the ecology and epidemiology of this pathogen in rural systems characterized by high rates of overlap among humans, domesticated animals, and wildlife. To improve our understanding of the zoonotic potential of Cryptosporidium species in the rural tropics, we screened humans, livestock, peridomestic rodents, and wildlife using PCR-RFLP and sequencing-based approaches to distinguish species of Cryptosporidium in rural southeastern Madagascar. Cryptosporidium of multiple species/genotypes were apparent in this study system. Interestingly, C. suis was the dominant species of Cryptosporidium in the region, infecting humans (n=1), cattle (n=18), pigs (n=3), and rodents (n=1). The broad species range of C suis and the lack of common cattle Cryptosporidium species (Cryptosporidium parvum and Cryptosporidium andersoni) in this system are unique. This report represents the fifth confirmed case of C suis infection in humans, and the first case in Africa. Few rural human and livestock populations have been screened for Cryptosporidium using genus-specific genotyping methods. Consequently, C suis may be more widespread in human and cattle populations than previously believed. (C) 2014 Elsevier B.V. All rights reserved. C1 [Bodager, Jonathan R.; Parsons, Michele B.; Gillespie, Thomas R.] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, GA 30322 USA. [Parsons, Michele B.; Gillespie, Thomas R.] Emory Univ, Dept Environm Sci, Atlanta, GA 30322 USA. [Parsons, Michele B.; Gillespie, Thomas R.] Emory Univ, Program Populat Biol Ecol & Evolut, Atlanta, GA 30322 USA. [Parsons, Michele B.; Roellig, Dawn; Xiao, Lihua] Ctr Dis Control & Prevent, Atlanta, GA 30322 USA. [Wright, Patricia C.; Rasambainarivo, Fidisoa; Gillespie, Thomas R.] Ctr ValBio, Ranomafana, Madagascar. [Wright, Patricia C.] SUNY Stony Brook, Stony Brook, NY 11790 USA. RP Gillespie, TR (reprint author), Emory Univ, Math & Sci Ctr, 400 Dowman Dr,Suite E510, Atlanta, GA 30322 USA. EM thomas.gillespie@emory.edu RI Xiao, Lihua/B-1704-2013 OI Xiao, Lihua/0000-0001-8532-2727 FU Jim and Robin Herrnstein Foundation; Emory University Global Health Institute; Stony Brook University; Centers for Disease Control and Prevention FX This study was supported by the Jim and Robin Herrnstein Foundation, the Emory University Global Health Institute, Stony Brook University, and Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 15 TC 6 Z9 7 U1 1 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4017 EI 1873-2550 J9 VET PARASITOL JI Vet. Parasitol. PD JAN 15 PY 2015 VL 207 IS 1-2 BP 140 EP 143 DI 10.1016/j.vetpar.2014.11.013 PG 4 WC Parasitology; Veterinary Sciences SC Parasitology; Veterinary Sciences GA CA5LF UT WOS:000348949200018 PM 25481280 ER PT J AU Nakamura, M Yokoyama, S Kayamori, Y Iso, H Kitamura, A Okamura, T Kiyama, M Noda, H Nishimura, K Nakai, M Koyama, I Dasti, M Vesper, HW Teramoto, T Miyamoto, Y AF Nakamura, Masakazu Yokoyama, Shinji Kayamori, Yuzo Iso, Hiroyasu Kitamura, Akihiko Okamura, Tomonori Kiyama, Masahiko Noda, Hiroyuki Nishimura, Kunihiro Nakai, Michikazu Koyama, Isao Dasti, Mahnaz Vesper, Hubert W. Teramoto, Tamio Miyamoto, Yoshihiro TI HDL cholesterol performance using an ultracentrifugation reference measurement procedure and the designated comparison method SO CLINICA CHIMICA ACTA LA English DT Article DE HDL cholesterol; Ultracentrifugation; Designated comparison method; CDC; CRMLN ID DENSITY-LIPOPROTEIN CHOLESTEROL; METHOD LABORATORY NETWORK; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; HOMOGENEOUS ASSAYS; LDL CHOLESTEROL; STANDARDIZATION; JAPANESE; RISK; ASSOCIATION AB Background: Accurate high-density lipoprotein cholesterol (HDL-C) measurements are important for management of cardiovascular diseases. The US Centers for Disease Control and Prevention (CDC) and Cholesterol Reference Method Laboratory Network (CRMLN) perform ultracentrifugation (UC) reference measurement procedure (RMP) to value assign HDL-C. Japanese CRMLN laboratory (Osaka) concurrently runs UC procedure and the designated comparison method (DCM). Osaka performance of UC and DCM was examined and compared with CDC RMP. Methods: CDC RMP involved UC, heparin-MnCl2 precipitation, and cholesterol analysis. CRMLN DCM for samples containing <200 mg/dl triglycerides involved 50-kDa dextran sulfate-MnCl2 precipitation and cholesterol determination. Results: HDL-C regression equations obtained with CDC (x) and Osaka (y) were y = 0.992x + 0.542 (R-2 = 0.996) for Osaka UC and y = 1.004x - 0.181 (R-2 = 0.998) for DCM. Pass rates within +/- 1 mg/dl of the CDC target value were 91.9 and 92.1% for Osaka UC and DCM, respectively. Biases at 40 mg/dl HDL-C were + 0.22 and -0.02 mg/dl for Osaka UC and DCM, respectively. Conclusions: Osaka UC and DCM were highly accurate, precise, and stable for many years, assisting manufacturers to calibrate products for clinical laboratories to accurately measure HDL-C for patients, calculate non-HDL-C, and estimate low-density lipoprotein cholesterol with the Friedewald equation. (C) 2014 Elsevier B.V. All rights reserved. C1 [Nakamura, Masakazu; Koyama, Isao] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Cardiol, Lipid Reference Lab, Suita, Osaka 5658565, Japan. [Yokoyama, Shinji] Chubu Univ, Nutr Hlth Sci Res Ctr, Kasugai, Aichi 487, Japan. [Kayamori, Yuzo] Kyushu Univ, Fac Med Sci, Dept Hlth Sci, Fukuoka 812, Japan. [Iso, Hiroyasu; Kitamura, Akihiko; Noda, Hiroyuki] Osaka Univ, Grad Sch Med, Dept Social & Environm Med, Suita, Osaka 565, Japan. [Okamura, Tomonori] Keio Univ, Dept Prevent Med & Publ Hlth, Tokyo 108, Japan. [Kiyama, Masahiko] Osaka Ctr Canc & Cardiovasc Dis Prevent, Osaka, Japan. [Noda, Hiroyuki] Minist Hlth Labour & Welf, Canc Control & Hlth Promot Div, Hlth Serv Bur, Sendai, Miyagi, Japan. [Nishimura, Kunihiro] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Med & Epidemiol Informat, Off Evidencebased Med & Risk Anal, Suita, Osaka 5658565, Japan. [Nakai, Michikazu] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Med & Epidemiol Informat, Suita, Osaka 5658565, Japan. [Dasti, Mahnaz; Vesper, Hubert W.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA USA. [Teramoto, Tamio] Teikyo Univ, Teikyo Acad Res Ctr, Tokyo 173, Japan. [Miyamoto, Yoshihiro] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Cardiol, Dept Prevent Med & Epidemiol Informat, Suita, Osaka 5658565, Japan. RP Nakamura, M (reprint author), Natl Cerebral & Cardiovasc Ctr, Dept Prevent Cardiol, Lipid Reference Lab, 5-7-1 Fujishirodai, Suita, Osaka 5658565, Japan. EM nakamura.masakazu.hp@ncvc.go.jp RI Okamura, Tomonori/L-1693-2013 OI Okamura, Tomonori/0000-0003-0488-0351 FU Minustry of Health, Labour, and Welfare of Japan FX This work was supported by a Health and Labour Sciences Research Grant, Japan (Comprehensive Research on Lyfestyle-Related Diseases Including Cardiovascular Diseases and Daibetes Mellitus) from the Minustry of Health, Labour, and Welfare of Japan. The authors would like to thank Dr. Katsuyuki Nakajima and Dr. Ikunosuke Sakurabayashi for their valuable comments and discussion, and Ms. Yukari Ichikawa for her excellent help in providing the references and manuscript. NR 28 TC 2 Z9 2 U1 9 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-8981 EI 1873-3492 J9 CLIN CHIM ACTA JI Clin. Chim. Acta PD JAN 15 PY 2015 VL 439 BP 185 EP 190 DI 10.1016/j.cca.2014.10.039 PG 6 WC Medical Laboratory Technology SC Medical Laboratory Technology GA AY3RG UT WOS:000347499700032 PM 25444739 ER PT J AU Correa, A Greer, S Sims, M AF Correa, Adolfo Greer, Sophia Sims, Mario TI Assessing Neighborhood-Level Effects on Disparities in Cardiovascular Diseases SO CIRCULATION LA English DT Editorial Material DE Editorials; cardiovascular diseases; disparities; healthcare; epidemiology; inequalities ID RESIDENTIAL SEGREGATION; RACIAL DISPARITIES; HEART-DISEASE; HEALTH C1 [Correa, Adolfo; Sims, Mario] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA. [Greer, Sophia] Ctr Dis Control & Prevent, Div Cardiovasc Dis & Stroke Prevent, Atlanta, GA USA. RP Correa, A (reprint author), Univ Mississippi, Med Ctr, Dept Med, 2500 North State St, Jackson, MS 39216 USA. EM acorrea@umc.edu FU Intramural CDC HHS [CC999999]; NHLBI NIH HHS [HHSN268201300046C, HHSN268201300049C]; NIMHD NIH HHS [P60 MD002249] NR 17 TC 1 Z9 1 U1 2 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0009-7322 EI 1524-4539 J9 CIRCULATION JI Circulation PD JAN 13 PY 2015 VL 131 IS 2 BP 124 EP 127 DI 10.1161/CIRCULATIONAHA.114.013871 PG 4 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AY8FY UT WOS:000347791000007 PM 25447043 ER PT J AU Geiss, LS Wang, J Gregg, EW AF Geiss, Linda S. Wang, Jing Gregg, Edward W. TI Reporting of Diabetes Trends Among Asian Americans, Native Hawaiians, and Pacific Islanders Reply SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter C1 [Geiss, Linda S.; Wang, Jing; Gregg, Edward W.] Ctr Dis Control & Prevent, Div Diabet Translat, Atlanta, GA 30341 USA. RP Geiss, LS (reprint author), Ctr Dis Control & Prevent, Div Diabet Translat, 4770 Buford Hwy NE, Atlanta, GA 30341 USA. EM lgeiss@cdc.gov NR 2 TC 1 Z9 1 U1 0 U2 4 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 13 PY 2015 VL 313 IS 2 BP 201 EP 202 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AY6MC UT WOS:000347679300026 PM 25585338 ER PT J AU Holt, JB Huston, SL Heidari, K Schwartz, R Gollmar, CW Tran, A Bryan, L Liu, Y Croft, JB AF Holt, James B. Huston, Sara L. Heidari, Khosrow Schwartz, Randy Gollmar, Charles W. Tran, Annie Bryan, Leah Liu, Yong Croft, Janet B. TI Indicators for Chronic Disease Surveillance - United States, 2013 SO MMWR RECOMMENDATIONS AND REPORTS LA English DT Article ID EXCESSIVE ALCOHOL-CONSUMPTION; NUTRITION-EXAMINATION-SURVEY; SERVICES TASK-FORCE; BODY-MASS INDEX; OBSTRUCTIVE PULMONARY-DISEASE; SUGAR-SWEETENED BEVERAGES; SIGNS BINGE DRINKING; DRAM SHOP LIABILITY; PAPILLOMAVIRUS-ASSOCIATED CANCERS; INVASIVE PNEUMOCOCCAL DISEASE AB Chronic diseases are an important public health problem, which can result in morbidity, mortality, disability, and decreased quality of life. Chronic diseases represented seven of the top 10 causes of death in the United States in 2010 (Murphy SL, Xu J, Kochanek KD. Deaths: final data for 2010. Natl Vital Stat Rep 2013; 6. Available at http://www.cdc.gov/nchs/data/nvsr/nvsr61/nvsr61_04.pdf). Chronic diseases and risk factors vary by geographic area such as state and county, where essential public health interventions are implemented. The chronic disease indicators (CDIs) were established in the late 1990s through collaboration among CDC, the Council of State and Territorial Epidemiologists, and the Association of State and Territorial Chronic Disease Program Directors (now the National Association of Chronic Disease Directors) to enable public health professionals and policymakers to retrieve data for chronic diseases and risk factors that have a substantial impact on public health. This report describes the latest revisions to the CDIs, which were developed on the basis of a comprehensive review during 2011-2013. The number of indicators is increasing from 97 to 124, with major additions in systems and environmental indicators and additional emphasis on high-impact diseases and conditions as well as emerging topics. C1 [Holt, James B.; Bryan, Leah; Liu, Yong; Croft, Janet B.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Atlanta, GA 30333 USA. [Huston, Sara L.] Council State & Territorial Epidemiologists, Atlanta, GA USA. [Huston, Sara L.; Tran, Annie] Univ So Maine, Portland, ME 04103 USA. [Heidari, Khosrow] S Carolina Dept Hlth & Environm Control, Columbia, SC 29201 USA. RP Holt, JB (reprint author), CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. EM jgh4@cdc.gov NR 473 TC 2 Z9 3 U1 5 U2 14 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1057-5987 EI 1545-8601 J9 MMWR RECOMM REP JI MMWR Recomm. Rep. PD JAN 9 PY 2015 VL 64 IS 1 BP 1 EP 246 PG 246 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CA5DN UT WOS:000348928400001 PM 25578080 ER PT J AU Walton, LR Orenstein, WA Pickering, LK AF Walton, L. Reed Orenstein, Walter A. Pickering, Larry K. TI The history of the United States Advisory Committee on Immunization Practices (ACIP) SO VACCINE LA English DT Editorial Material DE Immunization; Vaccination; History; Vaccinology; Legislation; Childhood immunization schedule; Adult immunization schedule; Harmonized schedule; Biologics; Recommendations; Advisory Committee on Immunization; Practices; ACIP; Measles; MMR; Rubella; Vaccines for Children Program; Patient Protection and Affordable Care Act; Catch-up schedule; Vaccine licensing; Vaccine development; Vaccine safety ID EVIDENCE-BASED RECOMMENDATIONS; MEASLES; SCHEDULE; VACCINE; INFLUENZA; PREVENTION; PROGRAM; WOMEN AB The United States Advisory Committee on Immunization Practices (ACIP) is a federal advisory committee that develops written recommendations for use of vaccines licensed by the Food and Drug Administration (FDA) for the U.S. civilian population. Vaccine development and disease outbreaks contributed to the need for a systematized, science-based, formal mechanism for establishing national immunization policy in this country. Formed in 1964, the ACIP was charged with this role. The committee has undergone significant changes in structure and operational activities during its 50-year history. The ACIP works closely with many liaison organizations to develop its immunization recommendations, which are harmonized among key professional medical societies. ACIP vaccine recommendations form two immunization schedules, which are updated annually: (1) the childhood and adolescent immunization schedule and (2) the adult immunization schedule. Today, once ACIP recommendations are adopted by the Director of the Centers for Disease Control and Prevention and the Secretary of the Department of Health and Human Services, these recommendations are published in Morbidity and Mortality Weekly Report (MMWR), become official policy, and are incorporated into the appropriate immunization schedule. Published by Elsevier Ltd. C1 [Walton, L. Reed] Ctr Dis Control & Prevent, Advisory Comm Immunizat Practices, Atlanta, GA 30333 USA. [Orenstein, Walter A.] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA. [Pickering, Larry K.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Advisory Comm Immunizat Practices, Atlanta, GA 30333 USA. [Pickering, Larry K.] Emory Univ, Sch Med, Atlanta, GA 30322 USA. RP Pickering, LK (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop A-27,Room 8236, Atlanta, GA 30333 USA. EM lpickering@cdc.gov NR 52 TC 7 Z9 7 U1 0 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 9 PY 2015 VL 33 IS 3 BP 405 EP 414 DI 10.1016/j.vaccine.2014.09.043 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AZ5NY UT WOS:000348268600002 PM 25446820 ER PT J AU Brinker, K Lumia, M Markiewicz, KV Duncan, MA Dowell, C Rey, A Wilken, J Shumate, A Taylor, J Funk, R AF Brinker, Kimberly Lumia, Margaret Markiewicz, Karl V. Duncan, Mary Anne Dowell, Chad Rey, Araceli Wilken, Jason Shumate, Alice Taylor, Jamille Funk, Renee TI Assessment of Emergency Responders After a Vinyl Chloride Release from a Train Derailment - New Jersey, 2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Brinker, Kimberly; Wilken, Jason; Shumate, Alice] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Brinker, Kimberly; Dowell, Chad; Rey, Araceli; Funk, Renee] CDC, Natl Inst Occupat Hlth & Safety, Atlanta, GA 30333 USA. [Lumia, Margaret; Shumate, Alice] New Jersey State Dept Hlth, Trenton, NJ 08625 USA. [Markiewicz, Karl V.; Duncan, Mary Anne; Taylor, Jamille] Agcy Tox Subst & Dis Registry, Atlanta, GA USA. RP Brinker, K (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM kbrinker@cdc.gov NR 6 TC 0 Z9 0 U1 1 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 9 PY 2015 VL 63 IS 53 BP 1233 EP 1237 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY5KY UT WOS:000347612100001 PM 25577988 ER PT J AU Kanny, D Brewer, RD Mesnick, JB Paulozzi, LJ Naimi, TS Lu, H AF Kanny, Dafna Brewer, Robert D. Mesnick, Jessica B. Paulozzi, Leonard J. Naimi, Timothy S. Lu, Hua TI Vital Signs: Alcohol Poisoning Deaths - United States, 2010-2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID BINGE DRINKING; US; CONSUMPTION; MORTALITY AB Background: Alcohol poisoning is typically caused by binge drinking at high intensity (i.e., consuming a very large amount of alcohol during an episode of binge drinking). Approximately 38 million U.S. adults report binge drinking an average of four times per month and consuming an average of eight drinks per episode. Methods: CDC analyzed data for 2010-2012 from the National Vital Statistics System to assess average annual alcohol poisoning deaths and death rates (ICD-10 codes X45 and Y15; underlying cause of death) in the United States among persons aged >= 15 years, by sex, age group, race/ethnicity, and state. Results: During 2010-2012, an annual average of 2,221 alcohol poisoning deaths (8.8 deaths per 1 million population) occurred among persons aged >= 15 years in the United States. Of those deaths, 1,681 (75.7%) involved adults aged 35-64 years, and 1,696 (76.4%) involved men. Although non-Hispanic whites accounted for the majority of alcohol poisoning deaths (67.5%; 1,500 deaths), the highest age-adjusted death rate was among American Indians/Alaska Natives (49.1 per 1 million). The age-adjusted rate of alcohol poisoning deaths in states ranged from 5.3 per 1 million in Alabama to 46.5 per 1 million in Alaska. Conclusions: On average, six persons, mostly adult men, die from alcohol poisoning each day in the United States. Alcohol poisoning death rates vary substantially by state. Implications for Public Health Practice: Evidence-based strategies for preventing excessive drinking (e.g., regulating alcohol outlet density and preventing illegal alcohol sales in retail settings) could reduce alcohol poisoning deaths by reducing the prevalence, frequency, and intensity of binge drinking. C1 [Kanny, Dafna; Brewer, Robert D.; Mesnick, Jessica B.; Lu, Hua] CDC, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Boston, MA 02111 USA. [Paulozzi, Leonard J.] CDC, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Boston, MA USA. [Naimi, Timothy S.] Boston Med Ctr, Gen Internal Med Sect, Boston, MA USA. RP Kanny, D (reprint author), CDC, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Boston, MA 02111 USA. EM dkanny@cdc.gov NR 23 TC 4 Z9 4 U1 0 U2 6 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 9 PY 2015 VL 63 IS 53 BP 1238 EP 1242 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY5KY UT WOS:000347612100002 PM 25577989 ER PT J AU Leshem, E AF Leshem, Eyal TI Acute Flaccid Myelitis Among Persons Aged <= 21 Years - United States, August 1-November 13, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Leshem, Eyal] CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. CDC, Div Vector Borne Dis, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. Childrens Hosp Colorado, Aurora, CO USA. Council State & Terr Epidemiologists, Atlanta, GA USA. RP Leshem, E (reprint author), CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM eleshem@cdc.gov NR 4 TC 19 Z9 19 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 9 PY 2015 VL 63 IS 53 BP 1243 EP 1244 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY5KY UT WOS:000347612100003 ER PT J AU Joyce, MP Kuhar, D Brooks, JT AF Joyce, M. Patricia Kuhar, David Brooks, John T. TI Occupationally Acquired HIV Infection Among Health Care Workers - United States, 1985-2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Joyce, M. Patricia; Brooks, John T.] CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Kuhar, David] CDC, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Joyce, MP (reprint author), CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM pjoyce@cdc.gov NR 3 TC 8 Z9 9 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 9 PY 2015 VL 63 IS 53 BP 1245 EP 1246 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY5KY UT WOS:000347612100004 PM 25577991 ER PT J AU Moore, SM Monaghan, A Borchert, JN Mpanga, JT Atiku, LA Boegler, KA Montenieri, J MacMillan, K Gage, KL Eisen, RJ AF Moore, Sean M. Monaghan, Andrew Borchert, Jeff N. Mpanga, Joseph T. Atiku, Linda A. Boegler, Karen A. Montenieri, John MacMillan, Katherine Gage, Kenneth L. Eisen, Rebecca J. TI Seasonal fluctuations of small mammal and flea communities in a Ugandan plague focus: evidence to implicate Arvicanthis niloticus and Crocidura spp. as key hosts in Yersinia pestis transmission SO PARASITES & VECTORS LA English DT Article ID WEST NILE REGION; PRAIRIE DOGS; USAMBARA MOUNTAINS; BUBONIC PLAGUE; NEW-MEXICO; TANZANIA; RISK; THRESHOLDS; PREDICTORS; DYNAMICS AB Background: The distribution of human plague risk is strongly associated with rainfall in the tropical plague foci of East Africa, but little is known about how the plague bacterium is maintained during periods between outbreaks or whether environmental drivers trigger these outbreaks. We collected small mammals and fleas over a two year period in the West Nile region of Uganda to examine how the ecological community varies seasonally in a region with areas of both high and low risk of human plague cases. Methods: Seasonal changes in the small mammal and flea communities were examined along an elevation gradient to determine whether small mammal and flea populations exhibit differences in their response to seasonal fluctuations in precipitation, temperature, and crop harvests in areas within (above 1300 m) and outside (below 1300 m) of a model-defined plague focus. Results: The abundance of two potential enzootic host species (Arvicanthis niloticus and Crocidura spp.) increased during the plague season within the plague focus, but did not show the same increase at lower elevations outside this focus. In contrast, the abundance of the domestic rat population (Rattus rattus) did not show significant seasonal fluctuations regardless of locality. Arvicanthis niloticus abundance was negatively associated with monthly precipitation at a six month lag and positively associated with current monthly temperatures, and Crocidura spp. abundance was positively associated with precipitation at a three month lag and negatively associated with current monthly temperatures. The abundance of A. niloticus and Crocidura spp. were both positively correlated with the harvest of millet and maize. Conclusions: The association between the abundance of several small mammal species and rainfall is consistent with previous models of the timing of human plague cases in relation to precipitation in the West Nile region. The seasonal increase in the abundance of key potential host species within the plague focus, but not outside of this area, suggests that changes in small mammal abundance may create favorable conditions for epizootic transmission of Y. pestis which ultimately may increase risk of human cases in this region. C1 [Moore, Sean M.; Monaghan, Andrew; Boegler, Karen A.; Montenieri, John; MacMillan, Katherine; Gage, Kenneth L.; Eisen, Rebecca J.] Natl Ctr Atmospher Res, Boulder, CO 80301 USA. [Moore, Sean M.; Borchert, Jeff N.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80522 USA. [Moore, Sean M.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA. [Mpanga, Joseph T.; Atiku, Linda A.] Uganda Virus Res Inst, Entebbe, Uganda. RP Moore, SM (reprint author), Natl Ctr Atmospher Res, 3090 Ctr Green Dr, Boulder, CO 80301 USA. EM smoore62@jhu.edu OI Monaghan, Andrew/0000-0002-8170-2359 NR 51 TC 3 Z9 3 U1 2 U2 15 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD JAN 8 PY 2015 VL 8 AR 11 DI 10.1186/s13071-014-0616-1 PG 15 WC Parasitology SC Parasitology GA CB5XK UT WOS:000349701100001 PM 25573253 ER PT J AU Kawwass, JF Kissin, DM Kulkarni, AD Creanga, AA Session, DR Callaghan, WM Jamieson, DJ AF Kawwass, Jennifer F. Kissin, Dmitry M. Kulkarni, Aniket D. Creanga, Andreea A. Session, Donna R. Callaghan, William M. Jamieson, Denise J. CA Natl ART Surveillance Syst NASS Gr TI Safety of Assisted Reproductive Technology in the United States, 2000-2011 SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter C1 [Kawwass, Jennifer F.; Session, Donna R.] Emory Univ, Sch Med, Div Reprod Endocrinol & Infertil, Atlanta, GA USA. [Kissin, Dmitry M.; Kulkarni, Aniket D.; Creanga, Andreea A.; Callaghan, William M.; Jamieson, Denise J.] US Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. RP Kawwass, JF (reprint author), 550 Peachtree St, Atlanta, GA 30308 USA. EM jennifer.kawwass@gmail.com NR 6 TC 7 Z9 8 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JAN 6 PY 2015 VL 313 IS 1 BP 88 EP 90 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AY3IQ UT WOS:000347478000021 PM 25562272 ER PT J AU Abrams, JY Weintraub, ES Baggs, JM McCarthy, NL Schonberger, LB Lee, GM Klein, NP Belongia, EA Jackson, ML Naleway, AL Nordin, JD Hambidge, SJ Belay, ED AF Abrams, Joseph Y. Weintraub, Eric S. Baggs, James M. McCarthy, Natalie L. Schonberger, Lawrence B. Lee, Grace M. Klein, Nicola P. Belongia, Edward A. Jackson, Michael L. Naleway, Allison L. Nordin, James D. Hambidge, Simon J. Belay, Ermias D. TI Childhood vaccines and Kawasaki disease, Vaccine Safety Datalink, 1996-2006 SO VACCINE LA English DT Article DE Kawasaki disease; Vaccine Safety Datalink; Adverse events; Vasculitis ID UNITED-STATES; INNATE IMMUNITY; IMMUNIZATION; CHILDREN; MODEL AB Background: Kawasaki disease is a childhood vascular disorder of unknown etiology. Concerns have been raised about vaccinations being a potential risk factor for Kawasaki disease. Methods: Data from the Vaccine Safety Datalink were collected on children aged 0-6 years at seven managed care organizations across the United States. Defining exposure as one of several time periods up to 42 days after vaccination, we conducted Poisson regressions controlling for age, sex, season, and managed care organization to determine if rates of physician-diagnosed and verified Kawasaki disease were elevated following vaccination compared to rates during all unexposed periods. We also performed case-crossover analyses to control for unmeasured confounding. Results: A total of 1,721,186 children aged 0-6 years from seven managed care organizations were followed for a combined 4,417,766 person-years. The rate of verified Kawasaki disease was significantly lower during the 1-42 days after vaccination (rate ratio = 0.50, 95% CL = 0.27-0.92) and 8-42 days after vaccination (rate ratio = 0.45, 95% CL = 0.22-0.90) compared to rates during unexposed periods. Breaking down the analysis by vaccination category did not identify a subset of vaccines which was solely responsible for this association. The case-crossover analyses revealed that children with Kawasaki disease had lower rates of vaccination in the 42 days prior to symptom onset for both physician-diagnosed Kawasaki disease (rate ratio = 0.79, 95% CL = 0.64-0.97) and verified Kawasaki disease (rate ratio = 038, 95% CL = 0.20-0.75). Conclusions: Childhood vaccinations' studied did not increase the risk of Kawasaki disease; conversely, vaccination was associated with a transient decrease in Kawasaki disease incidence. Verifying and understanding this potential protective effect could yield clues to the underlying etiology of Kawasaki disease. (C) 2014 Published by Elsevier Ltd. C1 [Abrams, Joseph Y.; Schonberger, Lawrence B.; Belay, Ermias D.] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. [Weintraub, Eric S.; Baggs, James M.; McCarthy, Natalie L.] Ctr Dis Control & Prevent, Div Healthcare Qual & Promot, Immunizat Safety Off, Atlanta, GA USA. [Lee, Grace M.] Harvard Pilgrim Hlth Care Inst, Boston, MA USA. [Klein, Nicola P.] Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA. [Belongia, Edward A.] Marshfield Clin Res Fdn, Marshfield, WI USA. [Jackson, Michael L.] Grp Hlth Res Inst, Seattle, WA USA. [Naleway, Allison L.] Kaiser Permanente Northwest, Portland, OR USA. [Nordin, James D.] HealthPartners Res Fdn, Minneapolis, MN USA. [Hambidge, Simon J.] Kaiser Permanente Colorado, Denver, CO USA. RP Abrams, JY (reprint author), Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Atlanta, GA 30333 USA. EM jabrams@cdc.gov FU Merck Co.; GlaxoSmithKline; Pfizer; Novartis; Sanofi Pasteur; Protein Science FX Dr. Klein has received research support for unrelated studies from Merck & Co., GlaxoSmithKline, Pfizer, Novartis, Sanofi Pasteur and Protein Science. NR 24 TC 8 Z9 8 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 3 PY 2015 VL 33 IS 2 BP 382 EP 387 DI 10.1016/j.vaccine.2014.10.044 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AZ5NX UT WOS:000348268500017 PM 25444786 ER PT J AU Bogoch, II Creatore, MI Cetron, MS Brownstein, JS Pesik, N Miniota, J Tam, T Hu, W Nicolucci, A Ahmed, S Yoon, JW Berry, I Hay, SI Anema, A Tatem, AJ MacFadden, D German, M Khan, K AF Bogoch, Isaac I. Creatore, Maria I. Cetron, Martin S. Brownstein, John S. Pesik, Nicki Miniota, Jennifer Tam, Theresa Hu, Wei Nicolucci, Adriano Ahmed, Saad Yoon, James W. Berry, Isha Hay, Simon I. Anema, Aranka Tatem, Andrew J. MacFadden, Derek German, Matthew Khan, Kamran TI Assessment of the potential for international dissemination of Ebola virus via commercial air travel during the 2014 west African outbreak SO LANCET LA English DT Article ID HEALTH REGULATIONS AB Background The WHO declared the 2014 west African Ebola epidemic a public health emergency of international concern in view of its potential for further international spread. Decision makers worldwide are in need of empirical data to inform and implement emergency response measures. Our aim was to assess the potential for Ebola virus to spread across international borders via commercial air travel and assess the relative efficiency of exit versus entry screening of travellers at commercial airports. Methods We analysed International Air Transport Association data for worldwide flight schedules between Sept 1, 2014, and Dec 31, 2014, and historic traveller flight itinerary data from 2013 to describe expected global population movements via commercial air travel out of Guinea, Liberia, and Sierra Leone. Coupled with Ebola virus surveillance data, we modelled the expected number of internationally exported Ebola virus infections, the potential effect of air travel restrictions, and the efficiency of airport-based traveller screening at international ports of entry and exit. We deemed individuals initiating travel from any domestic or international airport within these three countries to have possible exposure to Ebola virus. We deemed all other travellers to have no significant risk of exposure to Ebola virus. Findings Based on epidemic conditions and international flight restrictions to and from Guinea, Liberia, and Sierra Leone as of Sept 1, 2014 (reductions in passenger seats by 51% for Liberia, 66% for Guinea, and 85% for Sierra Leone), our model projects 2.8 travellers infected with Ebola virus departing the above three countries via commercial flights, on average, every month. 91 547 (64%) of all air travellers departing Guinea, Liberia, and Sierra Leone had expected destinations in low-income and lower-middle-income countries. Screening international travellers departing three airports would enable health assessments of all travellers at highest risk of exposure to Ebola virus infection. C1 [Bogoch, Isaac I.; MacFadden, Derek; Khan, Kamran] Univ Toronto, Dept Med, Div Infect Dis, Toronto, ON, Canada. [Bogoch, Isaac I.] Univ Hlth Network, Div Internal Med, Toronto, ON, Canada. [Bogoch, Isaac I.] Univ Hlth Network, Div Infect Dis, Toronto, ON, Canada. [Creatore, Maria I.; Miniota, Jennifer; Hu, Wei; Nicolucci, Adriano; Yoon, James W.; Berry, Isha; German, Matthew; Khan, Kamran] St Michaels Hosp, Li Ka Shing Knowledge Inst, Ctr Res Inner City Hlth, Toronto, ON M5B 1W8, Canada. [Cetron, Martin S.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA. [Brownstein, John S.] Harvard Univ, Sch Med, Ctr Biomed Informat, Boston, MA USA. [Brownstein, John S.; Anema, Aranka] Boston Childrens Hosp, Childrens Hosp Informat Program, Boston, MA USA. [Pesik, Nicki] Ctr Dis Control & Prevent, Quarantine & Border Hlth Serv Branch, Div Global Migrat & Quarantine, Atlanta, GA USA. [Tam, Theresa] Publ Hlth Agcy Canada, Hlth Secur Infrastruct Branch, Ottawa, ON, Canada. [Ahmed, Saad] Univ Western Ontario, Schulich Sch Med & Dent, London, ON, Canada. [Hay, Simon I.; Tatem, Andrew J.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Hay, Simon I.] Univ Oxford, Dept Zool, Spatial Ecol & Epidemiol Grp, Oxford OX1 3PS, England. [Anema, Aranka] Univ British Columbia, Fac Med, Dept Med, Vancouver, BC, Canada. [Tatem, Andrew J.] Univ Southampton, Dept Geog & Environm, Southampton, Hants, England. [Tatem, Andrew J.] Flowminder Fdn, Stockholm, Sweden. RP Khan, K (reprint author), St Michaels Hosp, 30 Bond St, Toronto, ON M5B 1W8, Canada. EM khank@smh.ca RI Hay, Simon/F-8967-2015 OI Hay, Simon/0000-0002-0611-7272 FU Canadian Institutes of Health Research FX Canadian Institutes of Health Research. NR 18 TC 40 Z9 41 U1 2 U2 74 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 EI 1474-547X J9 LANCET JI Lancet PD JAN 3 PY 2015 VL 385 IS 9962 BP 29 EP 35 DI 10.1016/S0140-6736(14)61828-6 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA AX8IW UT WOS:000347154200025 PM 25458732 ER PT J AU Smucker, BJ Drew, NM AF Smucker, Byran J. Drew, Nathan M. TI Approximate Model Spaces for Model-Robust Experiment Design SO TECHNOMETRICS LA English DT Article DE Supersaturated; D-optimality; Two-level designs ID SUPERSATURATED DESIGNS; EXCHANGE ALGORITHMS; FACTORIAL-DESIGNS; CRITERION; SELECTION AB Optimal designs depend upon a prespecified model form. A popular and effective model-robust alternative is to design with respect to a set of models instead of just one. However, model spaces associated with experiments of interest are often prohibitively large and so algorithmically generated designs are infeasible. Here, we present a simple method that largely eliminates this problem by choosing a small set of models that approximates the full set and finding designs that are explicitly robust for this small set. We build our procedure on a restricted columnwise-pairwise algorithm, and explore its effectiveness for two model spaces in the literature. For smaller full model spaces, we find that the designs constructed with the new method compare favorably with robust designs that use the full model space, with construction times reduced by orders of magnitude. We also construct designs that heretofore have been unobtainable due to the size of their model spaces. Supplementary material (available online) includes code, designs, and additional results. C1 [Smucker, Byran J.] Miami Univ, Dept Stat, Oxford, OH 45056 USA. [Drew, Nathan M.] NIOSH, Nanotechnol Res Ctr, Cincinnati, OH 45226 USA. RP Smucker, BJ (reprint author), Miami Univ, Dept Stat, Oxford, OH 45056 USA. EM smuckerb@miamioh.edu; drewnm@miamioh.edu FU Committee on Faculty Research at Miami University; College of Arts and Science FX The authors express their thanks to John Bailer and Steve Wright who gave feedback on an earlier version of this article. They also thank Brad Jones, who suggested the BIBD analogy. Additionally, the reviewers, the Associate Editor, and the Editor made suggestions that positively shaped the article. Jens Mueller provided vital computing assistance, and he is gratefully acknowledged. The first author also recognizes the support of the Committee on Faculty Research at Miami University as well as a summer research grant for new tenure-track faculty from the College of Arts and Science. The work of the second author was conducted at Miami University. NR 26 TC 0 Z9 0 U1 1 U2 5 PU AMER STATISTICAL ASSOC PI ALEXANDRIA PA 732 N WASHINGTON ST, ALEXANDRIA, VA 22314-1943 USA SN 0040-1706 EI 1537-2723 J9 TECHNOMETRICS JI Technometrics PD JAN 2 PY 2015 VL 57 IS 1 BP 54 EP 63 DI 10.1080/00401706.2014.897262 PG 10 WC Statistics & Probability SC Mathematics GA CC4SD UT WOS:000350342700006 ER PT J AU Mazurek, JM White, GE Rodman, C Schleiff, PL AF Mazurek, Jacek M. White, Gretchen E. Rodman, Chad Schleiff, Patricia L. TI Farm Work-Related Asthma Among US Primary Farm Operators SO JOURNAL OF AGROMEDICINE LA English DT Article DE occupational health; health surveys; Agriculture; epidemiology; asthma ID EXHALED NITRIC-OXIDE; OCCUPATIONAL ASTHMA; UNITED-STATES; EDUCATIONAL INTERVENTION; NONATOPIC ASTHMA; HEALTH; ADULTS; PREVALENCE; MANAGEMENT; CALIFORNIA AB The objective of this study was to estimate the prevalence of current asthma and the proportion of current asthma that is related to work on the farm among primary farm operators. The 2011 Farm and Ranch Safety Survey data were used to produce estimates and prevalence odds ratios. An estimated 5.1% of farm operators had asthma. Of these, 15.4% had farm work-related asthma. Among operators with farm work-related asthma, 54.8% (95% confidence interval [CI]: 41.8%-68.2%) had an asthma attack in the prior 12 months and 33.3% (95% CI: 21.2%-45.4%) had an asthma attack that occurred while doing farm work. Of those who had an asthma attack that occurred while doing farm work, 65.0% associated their asthma attack with plant/tree materials. This study provides updated information on asthma and the proportion of current asthma that is related to work on the farm and identifies certain groups of farm operators that might benefit from workplace asthma prevention intervention. C1 [Mazurek, Jacek M.; White, Gretchen E.; Rodman, Chad; Schleiff, Patricia L.] NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Mazurek, JM (reprint author), NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, 1095 Willowdale Rd,MS HG 900-2, Morgantown, WV 26505 USA. EM JMazurek1@cdc.gov FU Intramural CDC HHS [CC999999] NR 48 TC 1 Z9 1 U1 1 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1059-924X EI 1545-0813 J9 J AGROMEDICINE JI J. Agromedicine PD JAN 2 PY 2015 VL 20 IS 1 BP 31 EP 42 DI 10.1080/1059924X.2014.976729 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CA1HE UT WOS:000348662600007 PM 25635741 ER PT J AU Puckett, M Neri, A Thompson, T Underwood, JM Momin, B Kahende, J Zhang, L Stewart, SL AF Puckett, Mary Neri, Antonio Thompson, Trevor Underwood, J. Michael Momin, Behnoosh Kahende, Jennifer Zhang, Lei Stewart, Sherri L. TI Tobacco Cessation Among Users of Telephone and Web-Based Interventions - Four States, 2011-2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; SMOKING-CESSATION; PROGRAMS; PHONE C1 [Puckett, Mary] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Puckett, Mary; Neri, Antonio; Thompson, Trevor; Underwood, J. Michael; Momin, Behnoosh; Stewart, Sherri L.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Canc Prevent & Control, Atlanta, GA 30333 USA. [Kahende, Jennifer; Stewart, Sherri L.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Off Smoking & Hlth, Atlanta, GA 30333 USA. RP Puckett, M (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM mpuckettl@cdc.gov NR 10 TC 7 Z9 7 U1 1 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 2 PY 2015 VL 63 IS 51-52 BP 1217 EP 1221 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY5FQ UT WOS:000347598800001 PM 25551593 ER PT J AU Dynes, MM Miller, L Sam, T Vandi, MA Tomczyk, B AF Dynes, Michelle M. Miller, Laura Sam, Tamba Vandi, Mohamed Alex Tomczyk, Barbara TI Perceptions of the Risk for Ebola and Health Facility Use Among Health Workers and Pregnant and Lactating Women - Kenema District, Sierra Leone, September 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Dynes, Michelle M.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Tomczyk, Barbara] CDC, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Dynes, MM (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM mdynes@cdc.gov NR 3 TC 5 Z9 5 U1 0 U2 10 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 2 PY 2015 VL 63 IS 51-52 BP 1226 EP 1227 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY5FQ UT WOS:000347598800003 PM 25551595 ER PT J AU Croker, C Civen, R Keough, K Ngo, V Marutani, A Schwartz, B AF Croker, Curtis Civen, Rachel Keough, Kathleen Ngo, Van Marutani, Amy Schwartz, Benjamin TI Aseptic Meningitis Outbreak Associated with Echovirus 30 Among High School Football Players - Los Angeles County, California, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Editorial Material C1 [Croker, Curtis; Civen, Rachel; Ngo, Van; Marutani, Amy; Schwartz, Benjamin] Los Angeles Cty Dept Publ Hlth, Acute Communicable Dis Control Program, Los Angeles, CA 90007 USA. [Keough, Kathleen] CDC, Off State Tribal Local & Terr Support, Atlanta, GA 30333 USA. RP Croker, C (reprint author), Los Angeles Cty Dept Publ Hlth, Acute Communicable Dis Control Program, Los Angeles, CA 90007 USA. EM ccroker@ph.lacounty.gov NR 3 TC 2 Z9 2 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD JAN 2 PY 2015 VL 63 IS 51-52 BP 1228 EP 1228 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY5FQ UT WOS:000347598800004 PM 25551596 ER PT J AU Neafsey, DE Waterhouse, RM Abai, MR Aganezov, SS Alekseyev, MA Allen, JE Amon, J Arca, B Arensburger, P Artemov, G Assour, LA Basseri, H Berlin, A Birren, BW Blandin, SA Brockman, AI Burkot, TR Burt, A Chan, CS Chauve, C Chiu, JC Christensen, M Costantini, C Davidson, VLM Deligianni, E Dottorini, T Dritsou, V Gabriel, SB Guelbeogo, WM Hall, AB Han, MV Hlaing, T Hughes, DST Jenkins, AM Jiang, XF Jungreis, I Kakani, EG Kamali, M Kemppainen, P Kennedy, RC Kirmitzoglou, IK Koekemoer, LL Laban, N Langridge, N Lawniczak, MKN Lirakis, M Lobo, NF Lowy, E MacCallum, RM Mao, CH Maslen, G Mbogo, C McCarthy, J Michel, K Mitchell, SN Moore, W Murphy, KA Naumenko, AN Nolan, T Novoa, EM O'Loughlin, S Oringanje, C Oshaghi, MA Pakpour, N Papathanos, PA Peery, AN Povelones, M Prakash, A Price, DP Rajaraman, A Reimer, LJ Rinker, DC Rokas, A Russell, TL Sagnon, N Sharakhova, MV Shea, T Simao, FA Simard, F Slotman, MA Somboon, P Stegniy, V Struchiner, CJ Thomas, GWC Tojo, M Topalis, P Tubio, JMC Unger, MF Vontas, J Walton, C Wilding, CS Willis, JH Wu, YC Yan, GY Zdobnov, EM Zhou, XF Catteruccia, F Christophides, GK Collins, FH Cornman, RS Crisanti, A Donnelly, MJ Emrich, SJ Fontaine, MC Gelbart, W Hahn, MW Hansen, IA Howell, PI Kafatos, FC Kellis, M Lawson, D Louis, C Luckhart, S Muskavitch, MAT Ribeiro, JM Riehle, MA Sharakhov, IV Tu, ZJ Zwiebel, LJ Besansky, NJ AF Neafsey, Daniel E. Waterhouse, Robert M. Abai, Mohammad R. Aganezov, Sergey S. Alekseyev, Max A. Allen, James E. Amon, James Arca, Bruno Arensburger, Peter Artemov, Gleb Assour, Lauren A. Basseri, Hamidreza Berlin, Aaron Birren, Bruce W. Blandin, Stephanie A. Brockman, Andrew I. Burkot, Thomas R. Burt, Austin Chan, Clara S. Chauve, Cedric Chiu, Joanna C. Christensen, Mikkel Costantini, Carlo Davidson, Victoria L. M. Deligianni, Elena Dottorini, Tania Dritsou, Vicky Gabriel, Stacey B. Guelbeogo, Wamdaogo M. Hall, Andrew B. Han, Mira V. Hlaing, Thaung Hughes, Daniel S. T. Jenkins, Adam M. Jiang, Xiaofang Jungreis, Irwin Kakani, Evdoxia G. Kamali, Maryam Kemppainen, Petri Kennedy, Ryan C. Kirmitzoglou, Ioannis K. Koekemoer, Lizette L. Laban, Njoroge Langridge, Nicholas Lawniczak, Mara K. N. Lirakis, Manolis Lobo, Neil F. Lowy, Ernesto MacCallum, Robert M. Mao, Chunhong Maslen, Gareth Mbogo, Charles McCarthy, Jenny Michel, Kristin Mitchell, Sara N. Moore, Wendy Murphy, Katherine A. Naumenko, Anastasia N. Nolan, Tony Novoa, Eva M. O'Loughlin, Samantha Oringanje, Chioma Oshaghi, Mohammad A. Pakpour, Nazzy Papathanos, Philippos A. Peery, Ashley N. Povelones, Michael Prakash, Anil Price, David P. Rajaraman, Ashok Reimer, Lisa J. Rinker, David C. Rokas, Antonis Russell, Tanya L. Sagnon, N'Fale Sharakhova, Maria V. Shea, Terrance Simao, Felipe A. Simard, Frederic Slotman, Michel A. Somboon, Pradya Stegniy, Vladimir Struchiner, Claudio J. Thomas, Gregg W. C. Tojo, Marta Topalis, Pantelis Tubio, Jose M. C. Unger, Maria F. Vontas, John Walton, Catherine Wilding, Craig S. Willis, Judith H. Wu, Yi-Chieh Yan, Guiyun Zdobnov, Evgeny M. Zhou, Xiaofan Catteruccia, Flaminia Christophides, George K. Collins, Frank H. Cornman, Robert S. Crisanti, Andrea Donnelly, Martin J. Emrich, Scott J. Fontaine, Michael C. Gelbart, William Hahn, Matthew W. Hansen, Immo A. Howell, Paul I. Kafatos, Fotis C. Kellis, Manolis Lawson, Daniel Louis, Christos Luckhart, Shirley Muskavitch, Marc A. T. Ribeiro, Jose M. Riehle, Michael A. Sharakhov, Igor V. Tu, Zhijian Zwiebel, Laurence J. Besansky, Nora J. TI Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes SO SCIENCE LA English DT Article ID ANTENNAL TRANSCRIPTOME PROFILES; SEX-CHROMOSOME EVOLUTION; CUTICULAR PROTEIN GENES; AEDES-AEGYPTI; R CONSENSUS; GAMBIAE; DROSOPHILA; EXPRESSION; ANNOTATION; FAMILY AB Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning similar to 100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts. C1 [Neafsey, Daniel E.; Berlin, Aaron; Birren, Bruce W.; Shea, Terrance] Broad Inst, Genome Sequencing & Anal Program, Cambridge, MA 02142 USA. [Waterhouse, Robert M.; Chan, Clara S.; Jungreis, Irwin; Novoa, Eva M.; Wu, Yi-Chieh; Kellis, Manolis] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA. [Waterhouse, Robert M.; Chan, Clara S.; Jungreis, Irwin; Novoa, Eva M.; Wu, Yi-Chieh; Kellis, Manolis] Broad Inst Massachusetts Inst Technol & Harvard, Cambridge, MA 02142 USA. [Waterhouse, Robert M.; Simao, Felipe A.; Zdobnov, Evgeny M.] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland. [Waterhouse, Robert M.; Simao, Felipe A.; Zdobnov, Evgeny M.] Swiss Inst Bioinformat, CH-1211 Geneva, Switzerland. [Abai, Mohammad R.; Basseri, Hamidreza; Oshaghi, Mohammad A.] Univ Tehran Med Sci, Dept Med Entomol & Vector Control, Sch Publ Hlth, Tehran, Iran. [Abai, Mohammad R.; Basseri, Hamidreza; Oshaghi, Mohammad A.] Univ Tehran Med Sci, Inst Hlth Res, Tehran, Iran. [Aganezov, Sergey S.; Alekseyev, Max A.] George Washington Univ, Dept Math, Ashburn, VA 20147 USA. [Aganezov, Sergey S.; Alekseyev, Max A.] George Washington Univ, Computat Biol Inst, Ashburn, VA 20147 USA. [Allen, James E.; Christensen, Mikkel; Hughes, Daniel S. T.; Langridge, Nicholas; Lowy, Ernesto; Maslen, Gareth; Lawson, Daniel] EMBL EBI, Cambridge CB10 1SD, England. [Amon, James] Minist Hlth, Natl Vector Borne Dis Control Programme, Port Vila, Tafea Province, Vanuatu. [Arca, Bruno] Univ Roma La Sapienza, Div Parasitol, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy. [Arensburger, Peter; McCarthy, Jenny] Calif State Polytech Pomona, Dept Biol Sci, Pomona, CA 91768 USA. [Artemov, Gleb; Stegniy, Vladimir] Tomsk State Univ, Tomsk 634050, Russia. [Assour, Lauren A.; Emrich, Scott J.] Univ Notre Dame, Eck Inst Global Hlth, Dept Comp Sci & Engn, Notre Dame, IN 46556 USA. [Blandin, Stephanie A.] INSERM, U963, F-67084 Strasbourg, France. [Blandin, Stephanie A.] CNRS, UPR9022, IBMC, F-67084 Strasbourg, France. [Brockman, Andrew I.; Dottorini, Tania; Kirmitzoglou, Ioannis K.; Lawniczak, Mara K. N.; MacCallum, Robert M.; Nolan, Tony; Papathanos, Philippos A.; Christophides, George K.; Crisanti, Andrea; Kafatos, Fotis C.] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England. [Burkot, Thomas R.; Russell, Tanya L.] James Cook Univ, Australian Inst Trop Hlth Med, Fac Med Hlth & Mol Sci, Cairns 4870, Australia. [Burt, Austin; O'Loughlin, Samantha] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Ascot SL5 7PY, Berks, England. [Chauve, Cedric; Rajaraman, Ashok] Simon Fraser Univ, Dept Math, Burnaby, BC V5A 1S6, Canada. [Chiu, Joanna C.; Murphy, Katherine A.] Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA. [Costantini, Carlo; Simard, Frederic] Inst Rech Dev, Unites Mixtes Rech Malad Infect & Vecteurs Ecol G, F-64501 Montpellier, France. [Davidson, Victoria L. M.; Michel, Kristin] Kansas State Univ, Div Biol, Manhattan, KS 66506 USA. [Deligianni, Elena; Topalis, Pantelis; Louis, Christos] Fdn Res & Technol, Inst Mol Biol & Biotechnol, GR-70013 Iraklion, Crete, Greece. [Dritsou, Vicky; Papathanos, Philippos A.; Crisanti, Andrea; Louis, Christos] Univ Perugia, Ctr Funct Genom, I-06100 Perugia, Italy. [Gabriel, Stacey B.] Broad Inst, Cambridge, MA 02142 USA. [Guelbeogo, Wamdaogo M.; Sagnon, N'Fale] Ctr Natl Rech & Format Paludisme, Ouagadougou, Burkina Faso. [Hall, Andrew B.; Jiang, Xiaofang; Sharakhov, Igor V.; Tu, Zhijian] Virginia Polytech Inst & State Univ, Program Genet Bioinformat & Computat Biol, Blacksburg, VA 24061 USA. [Han, Mira V.] Univ Nevada, Sch Life Sci, Las Vegas, NV 89154 USA. [Hlaing, Thaung] Dept Med Res, Dagon Township 11191, Yangon, Myanmar. [Hughes, Daniel S. T.] Baylor Coll Med, Houston, TX 77030 USA. [Jenkins, Adam M.; Muskavitch, Marc A. T.] Boston Coll, Chestnut Hill, MA 02467 USA. [Jiang, Xiaofang; Tu, Zhijian] Virginia Polytech Inst & State Univ, Dept Biochem, Blacksburg, VA 24061 USA. [Kakani, Evdoxia G.; Mitchell, Sara N.; Catteruccia, Flaminia] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA. [Kakani, Evdoxia G.; Catteruccia, Flaminia] Univ Perugia, Dipartimento Med Sperimentale & Sci Biochim, Perugia, Italy. [Kamali, Maryam; Naumenko, Anastasia N.; Peery, Ashley N.; Sharakhova, Maria V.; Sharakhov, Igor V.] Virginia Polytech Inst & State Univ, Dept Entomol, Blacksburg, VA 24061 USA. [Kemppainen, Petri; Walton, Catherine] Univ Manchester, Fac Life Sci, Computat Evolutionary Biol Grp, Oxford M13 9PT, England. [Kennedy, Ryan C.] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA. [Kirmitzoglou, Ioannis K.] Univ Cyprus, Dept Biol Sci, Bioinformat Res Lab, CY-1678 Nicosia, Cyprus. [Koekemoer, Lizette L.] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Wits Res Inst Malaria, Fac Hlth Sci, ZA-2131 Johannesburg, South Africa. [Koekemoer, Lizette L.] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Vector Control Reference Unit, ZA-2131 Johannesburg, South Africa. [Laban, Njoroge] Natl Museums Kenya, Nairobi, Kenya. [Lirakis, Manolis; Vontas, John; Louis, Christos] Univ Crete, Dept Biol, GR-70013 Iraklion, Greece. [Lobo, Neil F.; Unger, Maria F.; Collins, Frank H.; Fontaine, Michael C.; Besansky, Nora J.] Univ Notre Dame, Eck Inst Global Hlth, Notre Dame, IN 46556 USA. [Lobo, Neil F.; Unger, Maria F.; Collins, Frank H.; Fontaine, Michael C.; Besansky, Nora J.] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA. [Mao, Chunhong] Virginia Polytech Inst & State Univ, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA. [Mbogo, Charles] Ctr Geog Med Res, Kenya Med Res Inst, Wellcome Trust Res Programme, Kilifi, Kenya. [Moore, Wendy; Oringanje, Chioma; Riehle, Michael A.] Univ Arizona, Dept Entomol, Tucson, AZ 85721 USA. [Pakpour, Nazzy; Luckhart, Shirley] Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA 95616 USA. [Povelones, Michael] Univ Penn, Sch Vet Med, Dept Pathol, Philadelphia, PA 19104 USA. [Prakash, Anil] Indian Council Med Res, Reg Med Res Ctr NE, Dibrugarh 786001, Assam, India. [Price, David P.; Hansen, Immo A.] New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA. [Price, David P.; Hansen, Immo A.] New Mexico State Univ, Mol Biol Program, Las Cruces, NM 88003 USA. [Reimer, Lisa J.; Donnelly, Martin J.] Univ Liverpool Liverpool Sch Trop Med, Dept Vector Biol, Liverpool L3 5QA, Merseyside, England. [Rinker, David C.; Rokas, Antonis] Vanderbilt Univ, Med Ctr, Ctr Human Genet Res, Nashville, TN 37235 USA. [Rokas, Antonis; Zhou, Xiaofan] Vanderbilt Univ, Dept Biol Sci, Nashville, TN 37235 USA. [Slotman, Michel A.] Texas A&M Univ, Dept Entomol, College Stn, TX 77807 USA. [Somboon, Pradya] Chiang Mai Univ, Fac Med, Dept Parasitol, Chiang Mai 50200, Thailand. [Struchiner, Claudio J.] Fundacao Oswaldo Cruz, Rio De Janeiro, RJ, Brazil. [Struchiner, Claudio J.] Univ Estado Rio de Janeiro, Inst Social Med, BR-20550011 Rio De Janeiro, Brazil. [Thomas, Gregg W. C.; Hahn, Matthew W.] Indiana Univ, Sch Informat & Comp, Bloomington, IN 47405 USA. [Tojo, Marta] Univ Santiago de Compostela, Inst Invest Sanitarias, Ctr Res Mol Med & Chron Dis, Sch Med,Dept Physiol, La Coruna, Spain. [Tubio, Jose M. C.] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England. [Wilding, Craig S.] Liverpool John Moores Univ, Sch Nat Sci & Psychol, Liverpool L3 3AF, Merseyside, England. [Willis, Judith H.; Cornman, Robert S.] Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA. [Wu, Yi-Chieh] Harvey Mudd Coll, Dept Comp Sci, Claremont, CA 91711 USA. [Yan, Guiyun] Univ Calif Irvine, Coll Hlth Sci, Program Publ Hlth, Irvine, CA 92697 USA. [Donnelly, Martin J.] Wellcome Trust Sanger Inst, Malaria Programme, Cambridge CB10 1SJ, England. [Fontaine, Michael C.] Univ Groningen, Ctr Evolutionary & Ecol Studies, Marine Evolut & Conservat Grp, NL-9747 AG Groningen, Netherlands. [Gelbart, William] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA. [Hahn, Matthew W.] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA. [Howell, Paul I.] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Muskavitch, Marc A. T.] Biogen Idec Inc, Cambridge, MA 02142 USA. [Ribeiro, Jose M.] NIAID, Lab Malaria & Vector Res, Rockville, MD 20852 USA. [Zwiebel, Laurence J.] Vanderbilt Univ & Med Ctr, Dept Biol Sci, Inst Chem Biol, Nashville, TN 37235 USA. [Zwiebel, Laurence J.] Vanderbilt Univ & Med Ctr, Dept Pharmacol, Inst Genet & Global Hlth, Nashville, TN 37235 USA. RP Neafsey, DE (reprint author), Broad Inst, Genome Sequencing & Anal Program, 415 Main St, Cambridge, MA 02142 USA. EM neafsey@broadinstitute.org; nbesansk@nd.edu RI Wilding, Craig/C-5500-2012; Novoa, Eva Maria/B-1004-2015; Rokas, Antonis/A-9775-2008; Alekseyev, Max/D-9362-2016; Waterhouse, Robert/A-1858-2010; Artemov, Gleb/N-7651-2014; Blandin, Stephanie/I-2786-2016; SIMARD, Frederic/J-9489-2016; Zdobnov, Evgeny/K-1133-2012; Stegniy, Vladimir/N-7656-2014; Tubio, Jose/H-5076-2015; Ribeiro, Jose/J-7011-2015; OI Wilding, Craig/0000-0001-5818-2706; Novoa, Eva Maria/0000-0001-5567-1299; Rokas, Antonis/0000-0002-7248-6551; Alekseyev, Max/0000-0002-5140-8095; Waterhouse, Robert/0000-0003-4199-9052; SIMARD, Frederic/0000-0002-2871-5329; Tubio, Jose/0000-0003-3540-2459; Arca, Bruno/0000-0002-4029-0984; Hahn, Matthew/0000-0002-5731-8808; Ribeiro, Jose/0000-0002-9107-0818 FU National Center for Biotechnology Information [PRJNA67511] FX All sequencing reads and genome assemblies have been submitted to the National Center for Biotechnology Information (umbrella BioProject ID, PRJNA67511). Genome and transcriptome assemblies are also available from VectorBase (https://vectorbase.org) and the Broad Institute (https://olive.broadinstitute.org/collections/anopheles.4). The authors acknowledge the NIH Eukaryotic Pathogen and Disease Vector Sequencing Project Working Group for guidance and development of this project. Sequence data generation was supported at the Broad Institute by the National Human Genome Research Institute (U54 HG003067). We thank the many members of the Broad Institute Genomics Platform and Genome Sequencing and Analysis Program who contributed to sequencing data generation and analysis. NR 53 TC 92 Z9 97 U1 31 U2 170 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD JAN 2 PY 2015 VL 347 IS 6217 AR UNSP 1258522 DI 10.1126/science.1258522 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AX7NK UT WOS:000347102300042 PM 25554792 ER PT S AU Keim, ME AF Keim, M. E. BE Watson, RR Tabor, JA Ehiri, JE Preedy, VR TI The public health impacts of natural disasters SO HANDBOOK OF PUBLIC HEALTH IN NATURAL DISASTERS: NUTRITION, FOOD, REMEDIATION AND PREPARATION SE Human Health Handbooks LA English DT Article; Book Chapter DE natural disasters; public health; mortality; morbidity ID POSTTRAUMATIC-STRESS-DISORDER; TSUNAMI-AFFECTED AREAS; SOUTHERN THAILAND; HURRICANE MITCH; CLIMATE-CHANGE; MENTAL-HEALTH; FLOODS; VULNERABILITY; ADAPTATION; EPIDEMICS AB Disasters may be classified according to the causative nature of the hazard as either natural or technological. Natural hazards originate from natural process or phenomenon as compared to technological hazards that originate from technological or industrial conditions, including accidents, dangerous procedures, infrastructure failures or specific human activities. Over the past century, the incidence of hydro-meteorological disasters has increased much more rapidly than disasters caused by geological or biological disasters. During the last 50 years, (1964-2013), natural disasters have affected 6.9 trillion people worldwide and caused US$ 2.6 trillion in damage. During this same time, the annual incidence of natural disasters has been increasing worldwide. In general, hydro-meteorological disasters are, by far, the most frequent disaster occurrences in the world, comprising 74% of all disasters worldwide during the past 50 years (1964-2013); as well as comprising 97% of all people affected by disasters; and 71% of all damage losses during that same time. During the past 50 years, floods were responsible for half of all the people affected by natural disasters worldwide, and drought was responsible for nearly 1/3 of all people affected. During the past 50 years, (1964-2013), natural disasters have comprised the overwhelming majority of the global burden of disasters. Natural disasters comprised 83% of all disasters during that time. Natural disasters were also responsible for 99% of deaths, 96% of injuries, 99% of all people affected and 99% of all people displaced by disasters worldwide during 1964-2013. C1 [Keim, M. E.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Agcy Tox Subst & Dis Registry, 4770 Buford Highway,MS F09, Atlanta, GA 30303 USA. RP Keim, ME (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Agcy Tox Subst & Dis Registry, 4770 Buford Highway,MS F09, Atlanta, GA 30303 USA. EM mjk9@cdc.gov NR 86 TC 0 Z9 0 U1 2 U2 2 PU WAGENINGEN ACAD PUBL PI WAGENINGEN PA POSTBUS 220, 6700 AE WAGENINGEN, NETHERLANDS SN 2212-375X BN 978-90-8686-806-3; 978-90-8686-257-3 J9 HUM HEALT HANDB PY 2015 VL 10 BP 33 EP 58 DI 10.3920/978-90-8686-806-3_2 D2 10.3920/ 978-90-8686-806-3 PG 26 WC Health Policy & Services; Public, Environmental & Occupational Health; Nutrition & Dietetics SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Nutrition & Dietetics GA BF9IH UT WOS:000385640500002 ER PT J AU Jin, G Deng, J Nguyen, T Gao, P Wooster, MT Qari, SH AF Jin, Guang Deng, Julia Tung Nguyen Gao, Pan Wooster, Mark T. Qari, Shoukat H. GP IEEE TI Efficient Cloud-based Real-Time Geo-Information Delivery for Mobile Users SO 2015 16TH IEEE INTERNATIONAL CONFERENCE ON MOBILE DATA MANAGEMENT, VOL 1 LA English DT Proceedings Paper CT IEEE 16th International Conference on Mobile Data Management MDM CY JUN 15-18, 2015 CL Pittsburgh, PA SP IEEE Comp Soc, IEEE Tech Comm Data Engn, Univ of Pittsburgh, USA, Natl Sci Fdn, USA, Aalborg Univ, Denmark, Hewlett Packard, Hewlett Packard Vertica, Conf Publishing Serv DE Cloud Computing; Mobile Computing; Geo-Information; Location-based Service; Stream Processing AB The increasing popularity of smart mobile devices enables a widespread use of Location Based Services (LBS). LBSs require real-time processing of frequent updating data (i.e., streams), and return customized results to mobile users based on their own locations. The mobile environment brings additional design and development considerations to LBS applications, such as real-time awareness, energy efficiency, and privacy preservation. In a recent project, we worked on the Emergency Medical Service as an example LBS application, and developed a Cloud-based LBS prototype, named as Early AleRt System (EARS), to deliver real-time emergency vehicle's information to smart mobile devices based on their geo-proximity. EARS leverages Cloud-based stream processing systems to address the real-time stream processing needs, and also develops effective methods to conserve energy consumption and preserve user privacy. EARS is an efficient approach to deliver real-time geo-information from the Cloud to mobile users, and can be easily generalized to other LBS applications in the mobile environment. C1 [Jin, Guang; Deng, Julia; Tung Nguyen; Gao, Pan] Intelligent Automat Inc, Rockville, MD 20855 USA. [Wooster, Mark T.; Qari, Shoukat H.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Jin, G (reprint author), Intelligent Automat Inc, Rockville, MD 20855 USA. EM gjin@i-a-i.com; hdeng@i-a-i.com; tnguyen@i-a-i.com; pgao@i-a-i.com; got1@cdc.gov; sqari@cdc.gov NR 3 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4799-9972-9 PY 2015 BP 251 EP 254 DI 10.1109/MDM.2015.22 PG 4 WC Computer Science, Information Systems; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BF1KL UT WOS:000380404900031 ER PT B AU Moore, LV Diez-Roux, AV AF Moore, Latetia V. Diez-Roux, Ana V. BE Morland, KB TI Measurement and Analytical Issues Involved in the Estimation of the Effects of Local Food Environments on Health Behaviors and Health Outcomes SO LOCAL FOOD ENVIRONMENTS: FOOD ACCESS IN AMERICA LA English DT Article; Book Chapter ID MARGINAL STRUCTURAL MODELS; COMMERCIAL DATA SOURCES; AGENT-BASED MODEL; NEIGHBORHOOD CHARACTERISTICS; PHYSICAL-ACTIVITY; DIET QUALITY; PROPENSITY SCORES; OUTLET DATABASES; FIELD VALIDATION; UNITED-STATES C1 [Moore, Latetia V.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30329 USA. [Diez-Roux, Ana V.] Drexel Univ, Sch Publ Hlth, Philadelphia, PA 19104 USA. RP Moore, LV (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30329 USA. NR 69 TC 1 Z9 1 U1 1 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-6779-5; 978-1-4665-6778-8 PY 2015 BP 205 EP 230 D2 10.1201/b17351 PG 26 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BF6CW UT WOS:000382977300009 ER PT J AU Rubin, CS Kunkel, R Grigg, C King, L AF Rubin, Carol S. Kunkel, Rebekah Grigg, Cheri King, Lonnie BE Zinsstag, J Schelling, E WaltnerToews, D Whittaker, M Tanner, M TI Evolution of the One Health Movement in the USA SO ONE HEALTH: THE THEORY AND PRACTICE OF INTEGRATED HEALTH APPROACHES LA English DT Article; Book Chapter ID SURVEILLANCE; MEDICINE; DISEASE C1 [Rubin, Carol S.; Kunkel, Rebekah; Grigg, Cheri] Ctr Dis Control & Prevent, Hlth Off 1, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd NE,MS A-30, Atlanta, GA 30333 USA. [King, Lonnie] Ohio State Univ, Coll Vet Med, Columbus, OH 43210 USA. RP Rubin, CS (reprint author), Ctr Dis Control & Prevent, Hlth Off 1, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd NE,MS A-30, Atlanta, GA 30333 USA. EM carolrubin.dvm@gmail.com; rkunkel@cdc.gov; cgrigg@cdc.gov; King.1518@osu.edu NR 45 TC 0 Z9 0 U1 1 U2 1 PU CABI PUBLISHING-C A B INT PI WALLINGFORD PA CABI PUBLISHING, WALLINGFORD 0X10 8DE, OXON, ENGLAND BN 978-1-78064-341-0 PY 2015 BP 318 EP 331 D2 10.1079/9781780643410.0000 PG 14 WC Public, Environmental & Occupational Health; Integrative & Complementary Medicine SC Public, Environmental & Occupational Health; Integrative & Complementary Medicine GA BE8TL UT WOS:000377025500030 ER PT S AU Lara, J Khudyakov, Y Rossi, L Vaughan, G AF Lara, James Khudyakov, Yury Rossi, Livia Vaughan, Gilberta GP IEEE TI Highlights: Predicting the cross-immunoreactivity of hepatitis C virus hyper-variable region 1 peptides using polynomial neural networks PNN models of HCV-HVR1 cross-reactivity SO 2015 IEEE 5TH INTERNATIONAL CONFERENCE ON COMPUTATIONAL ADVANCES IN BIO AND MEDICAL SCIENCES (ICCABS) SE International Conference on Computational Advances in Bio and Medical Sciences LA English DT Proceedings Paper CT 5th IEEE International Conference on Computational Advances in Bio and Medical Sciences (ICCABS) CY OCT 15-17, 2015 CL Miami, FL SP IEEE, Univ Connecticut, NSF, FIU Computat & Informat Sci, UConn, Booth Engn Ctr Adv Technol DE hepatitis C virus; polynomial neural networks (PNN); prediction; vaccine; linear projection; quantitative-structure-activity-relationship (QSAR) C1 [Lara, James; Khudyakov, Yury; Vaughan, Gilberta] Ctr Dis Control, Div Viral Hepatitis, Atlanta, GA 30333 USA. [Rossi, Livia] UNESP, IBILCE, Dept Biol, Sao Jose Do Rio Preto, Brazil. RP Lara, J (reprint author), Ctr Dis Control, Div Viral Hepatitis, Atlanta, GA 30333 USA. EM XZL5@CDC.GOV; YEK0@CDC.GOV; LIV.ROSSI@YAHOO.COM; JIV9@CDC.GOV NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2164-229X BN 978-1-4673-9664-6 J9 INT CONF COMPUT ADV PY 2015 PG 1 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BE9NT UT WOS:000377899500030 ER PT S AU Rytsareva, I Campo, DS Zheng, YL Sims, S Tetik, C Chirag, J Chockalingam, S Thankachan, SV Sue, A Aluru, S Khudyakov, Y AF Rytsareva, Inna Campo, David S. Zheng, Yueli Sims, Seth Tetik, Cansu Chirag, Jain Chockalingam, Sriram Thankachan, Sharma V. Sue, Amanda Aluru, Srinivas Khudyakov, Yury GP IEEE TI Efficient Detection of Viral Transmission with Threshold-based methods SO 2015 IEEE 5TH INTERNATIONAL CONFERENCE ON COMPUTATIONAL ADVANCES IN BIO AND MEDICAL SCIENCES (ICCABS) SE International Conference on Computational Advances in Bio and Medical Sciences LA English DT Proceedings Paper CT 5th IEEE International Conference on Computational Advances in Bio and Medical Sciences (ICCABS) CY OCT 15-17, 2015 CL Miami, FL SP IEEE, Univ Connecticut, NSF, FIU Computat & Informat Sci, UConn, Booth Engn Ctr Adv Technol DE Outbreak detection; Next-Generation Sequencing; Public health ID C VIRUS OUTBREAK; MOLECULAR EPIDEMIOLOGY; HEMODIALYSIS UNIT; INFECTION; STATES AB Hepatitis C is a major public health problem in the United States and worldwide. Outbreaks of hepatitis C virus (HCV) infections associated with unsafe injection practices, drug diversion, and other exposures to blood are difficult to detect and investigate. Molecular analysis has been frequently used in the study of HCV outbreaks and transmission chains; helping identify a cluster of sequences as linked by transmission if their genetic distances are below a previously defined threshold. However, HCV exists as a population of numerous variants in each infected individual and it has been observed that minority variants in the source are often the ones responsible for transmission, a situation that precludes the use of a single sequence per individual because many such transmissions would be missed. The use of Next- Generation Sequencing immensely increases the sensitivity of transmission detection but brings a considerable computational challenge because all sequences need to be compared among all pairs of samples. For instance, our relatively small dataset of 401 samples, a total of 80200 pairwise sample comparisons must be performed, which account for 4.56 x 1010 pairwise sequence comparisons. We present a fast and efficient three- step filtering strategy that removes 85.1% of all the pairwise sample comparisons and 91.0% of all pairwise sequence comparisons, accurately establishing which pairs of HCV samples are below the relatedness threshold This electronic document is a " live" template and already defines the components of your paper [title, text, heads, etc.] in its style sheet. C1 [Rytsareva, Inna; Campo, David S.; Sims, Seth; Sue, Amanda; Khudyakov, Yury] Ctr Dis Control & Prevent, Div Viral Hepatitis, Mol Epidemiol & Bioinformat Lab, Atlanta, GA USA. [Zheng, Yueli] Eagle Med Serv LLC, Atlanta, GA USA. [Zheng, Yueli] Ctr Dis Control & Prevent, NCEZID, Atlanta, GA USA. [Tetik, Cansu; Chirag, Jain; Thankachan, Sharma V.; Aluru, Srinivas] Georgia Inst Technol, Sch Computat Sci & Engn, Atlanta, GA 30332 USA. [Chockalingam, Sriram] Indian Inst Technol, Dept Comp Sci & Engn, Bombay, Maharashtra, India. RP Rytsareva, I (reprint author), Ctr Dis Control & Prevent, Div Viral Hepatitis, Mol Epidemiol & Bioinformat Lab, Atlanta, GA USA. EM ykb4@cdc.gov; fyv6@cdc.gov; yqb7@cdc.gov; xzy3@cdc.gov; cansu@gatech.edu; cjain@gatech.edu; sriram.pc@iitb.ac.in; sharma.thankachan@gatech.edu; ykr9@cdc.gov; aluru@cc.gatech.ed; yek0@cdc.gov NR 19 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2164-229X BN 978-1-4673-9664-6 J9 INT CONF COMPUT ADV PY 2015 PG 6 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BE9NT UT WOS:000377899500021 ER PT S AU Skums, P Glebova, O Campo, DS Li, NN Dimitrova, Z Sims, S Bunimovich, L Zelikovsky, A Khudyakov, Y AF Skums, Pavel Glebova, Olga Campo, David S. Li, Nana Dimitrova, Zoya Sims, Seth Bunimovich, Leonid Zelikovsky, Alex Khudyakov, Yury GP IEEE TI Algorithms for Prediction of Viral Transmission using Analysis of Intra-Host Viral Populations SO 2015 IEEE 5TH INTERNATIONAL CONFERENCE ON COMPUTATIONAL ADVANCES IN BIO AND MEDICAL SCIENCES (ICCABS) SE International Conference on Computational Advances in Bio and Medical Sciences LA English DT Proceedings Paper CT 5th IEEE International Conference on Computational Advances in Bio and Medical Sciences (ICCABS) CY OCT 15-17, 2015 CL Miami, FL SP IEEE, Univ Connecticut, NSF, FIU Computat & Informat Sci, UConn, Booth Engn Ctr Adv Technol AB Molecular analysis has become one of the major tools used for viral outbreak investigation and transmission network inference. We present two novel methods for accurate identification of transmission clusters and sources of infection for highly heterogeneous viruses such as HIV and HCV. Validation on data obtained from HCV outbreaks shows that the proposed algorithms outperform the state-of-the-art consensus-based methods both in true and false positive rates for transmission prediction, as well as in accuracy of source identification for outbreaks. C1 [Skums, Pavel; Campo, David S.; Li, Nana; Dimitrova, Zoya; Sims, Seth; Khudyakov, Yury] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bunimovich, Leonid] Georgia Inst Technol, Atlanta, GA 30332 USA. [Glebova, Olga; Zelikovsky, Alex] Georgia State Univ, Dept Comp Sci, Atlanta, GA 30303 USA. RP Skums, P (reprint author), Ctr Dis Control & Prevent, Atlanta, GA USA. EM kki8@cdc.gov; glebova@cs.gsu.edu; fyv6@cdc.gov; yni6@cdc.gov; izd7@cdc.gov; xzy3@cdc.gov; bunimovh@math.gatech.edu; alexz@cs.gsu.edu; yek0@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2164-229X BN 978-1-4673-9664-6 J9 INT CONF COMPUT ADV PY 2015 PG 1 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BE9NT UT WOS:000377899500023 ER PT J AU Cummings, KJ Kreiss, K AF Cummings, K. J. Kreiss, K. TI Distinct Characteristics Of Bronchiolar Disorders Related To Occupational And Environmental Exposures SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 15-20, 2015 CL Denver, CO SP Amer Thorac Soc C1 [Cummings, K. J.; Kreiss, K.] NIOSH, CDC, Morgantown, WV USA. EM cvx5@cdc.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2015 VL 191 MA A4660 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA DO2AW UT WOS:000377582806095 ER PT J AU Henneberger, PK Liang, X Lillienberg, L Dahlman-Hoglund, A Toren, KO Andersson, E AF Henneberger, P. K. Liang, X. Lillienberg, L. Dahlman-Hoglund, A. Toren, K. O. Andersson, E. TI The Performance Of Different Criteria For Self-Reported Occupational Exposure In A Study Of Exacerbation Of Asthma SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 15-20, 2015 CL Denver, CO SP Amer Thorac Soc C1 [Henneberger, P. K.; Liang, X.] NIOSH, CDC, Morgantown, WV USA. [Lillienberg, L.; Dahlman-Hoglund, A.; Toren, K. O.; Andersson, E.] Univ Gothenburg, Sahlgrenska Univ Hosp, Gothenburg, Sweden. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2015 VL 191 MA A2593 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA DO2AW UT WOS:000377582802447 ER PT J AU Hoppin, J Umbach, D Long, S London, S Henneberger, PK Blair, A Freeman, LB Sandler, DP AF Hoppin, J. Umbach, D. Long, S. London, S. Henneberger, P. K. Blair, A. Freeman, L. Beane Sandler, D. P. TI Pesticides Are Associated With Allergic And Non-Allergic Wheeze Among Male Farmers SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 15-20, 2015 CL Denver, CO SP Amer Thorac Soc C1 [Hoppin, J.] N Carolina State Univ, Raleigh, NC 27695 USA. [Umbach, D.] NIEHS, Res Triangle Pk, NC USA. [Long, S.] Westat Corp, Durham, NC USA. [London, S.; Sandler, D. P.] NIEHS, Res Triangle Pk, NC 27709 USA. [Henneberger, P. K.] NIOSH, CDC, Morgantown, WV USA. [Blair, A.; Freeman, L. Beane] NCI, Rockville, MD USA. EM jahoppin@ncsu.edu RI Beane Freeman, Laura/C-4468-2015 OI Beane Freeman, Laura/0000-0003-1294-4124 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2015 VL 191 MA A6263 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA DO2AW UT WOS:000377582808498 ER PT J AU Mirabelli, MC Vaidyanathan, A Qin, X Garbe, PL AF Mirabelli, M. C. Vaidyanathan, A. Qin, X. Garbe, P. L. TI County-Level Pm2.5 And Asthma Symptoms In The Past 14 Days Among Adults With Active Asthma In The United States SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 15-20, 2015 CL Denver, CO SP Amer Thorac Soc C1 [Mirabelli, M. C.; Vaidyanathan, A.; Qin, X.; Garbe, P. L.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. NR 0 TC 1 Z9 1 U1 1 U2 1 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2015 VL 191 MA A6264 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA DO2AW UT WOS:000377582808499 ER PT J AU Patel, BK Shibib, DR Wolfe, KS Beavis, KG Nix, WA Strek, ME White, SR AF Patel, B. K. Shibib, D. R. Wolfe, K. S. Beavis, K. G. Nix, W. A. Strek, M. E. White, S. R. TI Enterovirus D68 Is Not Just For The Kiddos: A Case Series Of Adult Patients With Respiratory Illness SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 15-20, 2015 CL Denver, CO SP Amer Thorac Soc C1 [Patel, B. K.; Shibib, D. R.; Wolfe, K. S.; Beavis, K. G.; Strek, M. E.; White, S. R.] Univ Chicago, Chicago, IL 60637 USA. [Nix, W. A.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2015 VL 191 MA A1765 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA DO2AW UT WOS:000377582801164 ER PT J AU Pleasants, RA Wheaton, AG Croft, JB Liu, Y Heidari, K Ohar, JA Kraft, M Lugogo, N Mannino, DM Strange, CB AF Pleasants, R. A. Wheaton, A. G. Croft, J. B. Liu, Y. Heidari, K. Ohar, J. A. Kraft, M. Lugogo, N. Mannino, D. M. Strange, C. B. TI Sex-Based Differences In Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome In Respiratory Symptoms, Health Impairment, And Comorbidities SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 15-20, 2015 CL Denver, CO SP Amer Thorac Soc C1 [Pleasants, R. A.] Duke Univ, Durham, NC USA. [Wheaton, A. G.; Croft, J. B.; Liu, Y.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Heidari, K.] South Carolina Dept Environm Hlth Control, Columbia, SC USA. [Ohar, J. A.] Wake Forest Univ, Winston Salem, NC 27109 USA. [Kraft, M.; Lugogo, N.] Duke Univ, Med Ctr, Durham, NC USA. [Mannino, D. M.] Univ Kentucky, Coll Publ Hlth, Lexington, KY USA. [Strange, C. B.] Med Univ S Carolina, Charleston, SC 29425 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2015 VL 191 MA A4452 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA DO2AW UT WOS:000377582805511 ER PT J AU Reddy, D Weinberg, J Moro, R Feng, PJ Goldberg, S Saukkonen, JJ AF Reddy, D. Weinberg, J. Moro, R. Feng, P. -J. Goldberg, S. Saukkonen, J. J. TI Patterns Of Alanine Transaminase Rise In Tuberculosis Drug-Induced Hepatotoxicity SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 15-20, 2015 CL Denver, CO SP Amer Thorac Soc C1 [Reddy, D.] Montefiore Med Ctr, Albert Einstein Coll Med, Bronx, NY 10467 USA. [Weinberg, J.] Boston Univ, Sch Publ Hlth, Boston, MA USA. [Moro, R.; Feng, P. -J.; Goldberg, S.] CDC, Atlanta, GA 30333 USA. [Feng, P. -J.; Saukkonen, J. J.] Boston Univ, Sch Med, Boston, MA 02118 USA. EM divya.reddy@einstein.yu.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2015 VL 191 MA A3318 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA DO2AW UT WOS:000377582803592 ER PT J AU Soyseth, V Henneberger, PK Virji, MA Bakke, B Kongerud, JS AF Soyseth, V. Henneberger, P. K. Virji, M. A. Bakke, B. Kongerud, J. S. TI Exposure To Polycyclic Aromatic Hydrocarbons In Aluminum Pot Operators Is Associated With Increased Annual Decline In Fev1 SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT International Conference of the American-Thoracic-Society (ATS) CY MAY 15-20, 2015 CL Denver, CO SP Amer Thorac Soc C1 [Soyseth, V.] Univ Oslo, Lorenskog, Norway. [Henneberger, P. K.] NIOSH, CDC, Morgantown, WV USA. [Virji, M. A.] NIOSH, Morgantown, WV USA. [Bakke, B.] Natl Inst Occ Hlth, Oslo, Norway. [Kongerud, J. S.] Univ Oslo, Oslo, Norway. EM vidar.soyseth@medisin.uio.no NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA SN 1073-449X EI 1535-4970 J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2015 VL 191 MA A2588 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA DO2AW UT WOS:000377582802442 ER PT J AU Gounder, P Bulkow, LR Bruce, MG Hennessy, T Snowball, M Adhikari, B Meltzer, M Spradling, P McMahon, BJ AF Gounder, P. Bulkow, L. R. Bruce, M. G. Hennessy, T. Snowball, M. Adhikari, B. Meltzer, M. Spradling, P. McMahon, B. J. TI Comparing the Cost-Effectiveness of Two Approaches to Hepatocellular Carcinoma (HCC) Surveillance in Persons with Chronic Hepatitis B (CHB) Virus Infection. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Gounder, P.] Ctr Dis Control & Prevent, Anchorage, AK USA. [Bulkow, L. R.; Bruce, M. G.; Hennessy, T.] CDC, Arctic Invest Program, Anchorage, AK USA. [Snowball, M.; McMahon, B. J.] Alaska Native Tribal Hlth Consortium, Anchorage, AK USA. [Adhikari, B.; Meltzer, M.; Spradling, P.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 3216 BP 22 EP 23 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900053 ER PT J AU Bourgeois, AC Zulz, T AF Bourgeois, A. C. Zulz, T. TI Epidemiology of Tuberculosis in Circumpolar Regions: A First Glance. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Bourgeois, A. C.] Publ Hlth Agcy Canada, Ottawa, ON, Canada. [Zulz, T.] CDC, Anchorage, AK USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 2460 BP 23 EP 24 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900054 ER PT J AU Bourgeois, AC Zulz, T AF Bourgeois, A. C. Zulz, T. TI Descriptive Review of Tuberculosis Surveillance Systems across Circumpolar Regions. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Bourgeois, A. C.] Publ Hlth Agcy Canada, Ottawa, ON, Canada. [Zulz, T.] CDC, Anchorage, AK USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 3197 BP 24 EP 24 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900055 ER PT J AU Jones, CK Palipudi, KM Sinha, D Asma, S AF Jones, C. K. Palipudi, K. M. Sinha, D. Asma, S. TI Current Use of Other Tobacco Products in Six Countries in the South-East Asia Region: Findings from the Global Youth Tobacco Survey. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Jones, C. K.; Palipudi, K. M.; Asma, S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Sinha, D.] WHO, New Delhi, India. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 3790 BP 32 EP 32 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900074 ER PT J AU Mbulo, L Palipudi, KM Andes, L Asma, S Sinha, D Ratsimbazafy, RR Rarick, J Caixeta, RDB Khoury, R AF Mbulo, L. Palipudi, K. M. Andes, L. Asma, S. Sinha, D. Ratsimbazafy, R. R. Rarick, J. Caixeta, R. D. B. Khoury, R. TI Secondhand Smoke Exposure among 3.2 Billion Children in 20 Countries. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Mbulo, L.; Palipudi, K. M.; Andes, L.; Asma, S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Sinha, D.] WHO, New Delhi, India. [Ratsimbazafy, R. R.] WHO, AFRO, Brazzaville, Congo. [Rarick, J.] WHO, Manila, Philippines. [Caixeta, R. D. B.] WHO, Reg Off Amer, Washington, DC USA. [Khoury, R.] WHO, Copenhagen, Denmark. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 3819 BP 32 EP 33 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900075 ER PT J AU Ridgway, E Chaussard, M Lee, KA Kirksey-Jones, C Ramanandraibe, N Fouad, H Caixeta, R Khoury, R Sinha, D Rarick, J AF Ridgway, E. Chaussard, M. Lee, K. A. Kirksey-Jones, C. Ramanandraibe, N. Fouad, H. Caixeta, R. Khoury, R. Sinha, D. Rarick, J. TI Change in Tobacco Use Among 13-15 Year Olds Worldwide between 1999 and 2012-findings from the Global Youth Tobacco Survey. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Ridgway, E.; Chaussard, M.; Lee, K. A.; Kirksey-Jones, C.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Ramanandraibe, N.] WHO, Brazzaville, Congo. [Fouad, H.] WHO, Cairo, Egypt. [Caixeta, R.] WHO, Washington, DC USA. [Khoury, R.] WHO, Copenhagen, Denmark. [Sinha, D.] WHO, New Delhi, India. [Rarick, J.] WHO, Manila, Philippines. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 3647 BP 32 EP 32 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900073 ER PT J AU Johnston, JM Ferucci, E Gaddy, J Sumner, L Posever, J Choromanski, T Gordon, C Lim, SS Helmick, C AF Johnston, J. M. Ferucci, E. Gaddy, J. Sumner, L. Posever, J. Choromanski, T. Gordon, C. Lim, S. S. Helmick, C. TI Population-based Indian Health Service Lupus Registry Finds High Prevalence of Systemic Lupus Erythematosus Among AI/AN Women. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Johnston, J. M.] Univ Alaska Anchorage, Anchorage, AK USA. [Ferucci, E.; Choromanski, T.] ANTHC, Anchorage, AK USA. [Gaddy, J.] Oklahoma City Area Indian Hlth Serv, Oklahoma City, OK USA. [Sumner, L.; Posever, J.] Phoenix Indian Med Ctr, Phoenix, AZ USA. [Gordon, C.] Univ Birmingham, Birmingham, W Midlands, England. [Lim, S. S.] Emory Univ, Atlanta, GA 30322 USA. [Helmick, C.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 3457 BP 34 EP 34 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900078 ER PT J AU McMahon, BJ Bulkow, LR Gounder, P Townshend, L Negus, S Snowball, M Homan, C Simons, BC Livingston, S AF McMahon, B. J. Bulkow, L. R. Gounder, P. Townshend, L. Negus, S. Snowball, M. Homan, C. Simons, B. C. Livingston, S. TI Impact of Programs to Manage Alaska Native Patients with Chronic Hepatitis B and C in Urban and Remote Rural Areas using a Data Base Registry. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [McMahon, B. J.; Townshend, L.; Negus, S.; Snowball, M.; Homan, C.; Simons, B. C.] Alaska Native Tribal Hlth Consortium, Anchorage, AK USA. [Bulkow, L. R.] CDC Arctic Invest Program, Anchorage, AK USA. [Gounder, P.] Ctr Dis Control & Prevent, Anchorage, AK USA. [Livingston, S.] ANTHC, Anchorage, AK USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 3119 BP 57 EP 58 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900128 ER PT J AU Barata, RB Ribeiro, MC Moraes, JC Flannery, B Flannery, B AF Barata, R. B. Ribeiro, M. C. Moraes, J. C. Flannery, B. Flannery, B. TI Socioeconomic Inequalities and Vaccination Coverage: Results of an Immunization Coverage Survey in 27 Brazilian Capitals, 2007-08, Brazil SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Barata, R. B.; Ribeiro, M. C.; Moraes, J. C.] Santa Casa Sao Paulo Sch Med, Sao Paulo, Brazil. [Flannery, B.; Flannery, B.] CDC, Atlanta, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 1916 BP 81 EP 81 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900183 ER PT J AU Holman, RC Hennessy, T Singleton, RJ Seeman, SM Redd, JT Steiner, CA Bartholomew, ML Bruce, MG AF Holman, R. C. Hennessy, T. Singleton, R. J. Seeman, S. M. Redd, J. T. Steiner, C. A. Bartholomew, M. L. Bruce, M. G. TI Infectious Disease Hospitalizations among Alaska Native Infants, Alaska, USA. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Holman, R. C.; Seeman, S. M.] CDC, Atlanta, GA USA. [Hennessy, T.; Bruce, M. G.] CDC Arctic Invest Program, Anchorage, AK USA. [Singleton, R. J.] ANTHC, Anchorage, AK USA. [Redd, J. T.] IHS, Santa Fe, NM USA. [Steiner, C. A.] AHRQ, Rockville, MD USA. [Bartholomew, M. L.] IHS, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 1881 BP 99 EP 99 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900229 ER PT J AU Marcinkevage, JA Leman, RF Warren-Mears, V Weiser, T AF Marcinkevage, J. A. Leman, R. F. Warren-Mears, V. Weiser, T. TI Using Electronically Archived Medical Information for Public Health: Analysis of American Indian/Alaska Native Communicable Disease Diagnoses from the Indian Health Service National Data Warehouse-Oregon 2007-11. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Marcinkevage, J. A.; Warren-Mears, V.; Weiser, T.] Northwest Portland Area Indian Hlth Board, Portland, OR USA. [Marcinkevage, J. A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Leman, R. F.] Oregon Hlth Author, Portland, OR USA. [Weiser, T.] Portland Area Indian Hlth Serv, Portland, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 2018 BP 118 EP 118 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900285 ER PT J AU Morton, J Palipudi, KM Mbulo, L Blutcher-Nelson, G Kosen, S Hiong, TG Abdalla, AME Barbouni, A Antoniadou, E Asma, S AF Morton, J. Palipudi, K. M. Mbulo, L. Blutcher-Nelson, G. Kosen, S. Hiong, T. Guat Abdalla, A. Mohamed Elkhatim Barbouni, A. Antoniadou, E. Asma, S. TI Awareness and Use of Electronic Cigarettes in Indonesia, Malaysia, Qatar, and Greece - Global Adult Tobacco Survey 2010-13. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Morton, J.; Palipudi, K. M.; Mbulo, L.; Blutcher-Nelson, G.; Asma, S.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Kosen, S.] Natl Inst Hlth Res & Dev, Jakarta, Indonesia. [Hiong, T. Guat] Inst Publ Hlth, Kuala Lumpur, Malaysia. [Abdalla, A. Mohamed Elkhatim] Supreme Council Hlth, Doha, Qatar. [Barbouni, A.; Antoniadou, E.] Natl Sch Publ Hlth, Athens, Greece. NR 0 TC 0 Z9 0 U1 1 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 2385 BP 137 EP 137 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900336 ER PT J AU Okall, DA Otieno, FO Nyikuri, MO Mills, LA Hardnet, F Turner, K Gust, DA AF Okall, D. A. Otieno, F. O. Nyikuri, M. O. Mills, L. A. Hardnet, F. Turner, K. Gust, D. A. TI Men Who Have Sex with Men (MSM) in Kisumu, Kenya: Membership in a Support Group and Knowledge of HIV Risk Factors. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Okall, D. A.; Otieno, F. O.; Nyikuri, M. O.] KEMRI CDC Res & Publ Hlth Collaborat, Kisumu, Kenya. [Mills, L. A.; Hardnet, F.; Gust, D. A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Turner, K.] Univ Georgia, Athens, GA 30602 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 2449 BP 141 EP 141 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900347 ER PT J AU Singleton, R Foote, E Holman, RC Hennessy, T Bartholomew, ML Seeman, SM Bruce, MG Groom, A AF Singleton, R. Foote, E. Holman, R. C. Hennessy, T. Bartholomew, M. L. Seeman, S. M. Bruce, M. G. Groom, A. TI Pneumonia Hospitalizations among American Indian and Alaska Native Children after a Decade of Pneumococcal Vaccine. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Singleton, R.] Alaska Native Tribal Hlth Consortium, Anchorage, AK USA. [Foote, E.] Seattle Childrens Hosp, Seattle, WA USA. [Holman, R. C.; Seeman, S. M.] CDC, Atlanta, GA 30333 USA. [Hennessy, T.; Bruce, M. G.] CDC Arctic Invest Program, Anchorage, AK USA. [Bartholomew, M. L.] IHS, Rockville, MD USA. [Groom, A.] Ctr Dis Control Field Assignee, Indian Hlth Serv, Albuquerque, NM USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 2777 BP 155 EP 156 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900387 ER PT J AU Hsia, J Zhang, X Puckcharern, H AF Hsia, J. Zhang, X. Puckcharern, H. TI Estimation of Provincial Tobacco Use in Thailand Using Multilevel Small Area Estimation from a National Probability Sample. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Hsia, J.; Zhang, X.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Puckcharern, H.] Natl Stat Off Thailand, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 2634 BP 173 EP 173 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900436 ER PT J AU Bruce, MG Zulz, T Debyle, C Singleton, R Hurlburt, D Bruden, D Rudolph, K Hennessy, T Klejka, J Wenger, J AF Bruce, M. G. Zulz, T. Debyle, C. Singleton, R. Hurlburt, D. Bruden, D. Rudolph, K. Hennessy, T. Klejka, J. Wenger, J. TI Invasive Disease Caused by Haemophilus Influenzae Serotype a, an Emerging Pathogen in Alaska. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Bruce, M. G.; Hurlburt, D.; Bruden, D.; Hennessy, T.] CDC Arctic Invest Program, Anchorage, AK USA. [Zulz, T.; Debyle, C.; Rudolph, K.] CDC, Anchorage, AK USA. [Singleton, R.] Alaska Native Med Ctr, Anchorage, AK USA. [Klejka, J.] YKHC Hosp, Bethel, AK USA. [Wenger, J.] Bill & Melinda Gates Fdn, Seattle, WA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 2632 BP 195 EP 195 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900499 ER PT J AU Nguyen, M Husain, M Asma, S Palipudi, KM Ridgway, E AF Nguyen, M. Husain, M. Asma, S. Palipudi, K. M. Ridgway, E. TI Tracking MPOWER across Asian Countries - Results from the Global Adult Tobacco Survey, 2008-11. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Nguyen, M.; Husain, M.; Asma, S.; Palipudi, K. M.; Ridgway, E.] US Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 3359 BP 218 EP 219 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900563 ER PT J AU Singh, SD Ryerson, AB Wu, M Kaur, JS AF Singh, S. D. Ryerson, A. B. Wu, M. Kaur, J. S. TI Ovarian and Uterine Cancer Incidence and Mortality in Non-Hispanic American Indians and Alaska Native Women, United States, 1999-09. SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Singh, S. D.; Ryerson, A. B.; Wu, M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kaur, J. S.] Mayo Clin, Coll Med, Rochester, MN USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 3338 BP 219 EP 219 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900565 ER PT J AU Gounder, P Zulz, T Desai, S Stenz, F Rudolph, K Li, A Bruce, MG AF Gounder, P. Zulz, T. Desai, S. Stenz, F. Rudolph, K. Li, A. Bruce, M. G. TI Epidemiology of Meningitis Caused by Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae in the North American Arctic, 2000a 10 SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th IEA World Congress of Epidemiology (WCE) CY AUG 17-21, 2014 CL Anchorage, AK SP Int Epidemiol Assoc C1 [Gounder, P.] Ctr Dis Control & Prevent, Anchorage, AK USA. [Zulz, T.; Rudolph, K.] CDC, Anchorage, AK USA. [Desai, S.; Li, A.] Publ Hlth Agcy Canada, Ottawa, ON, Canada. [Stenz, F.] Govt Greenland, Nuuk, Greenland. [Bruce, M. G.] CDC Arctic Invest Program, Anchorage, AK USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0300-5771 EI 1464-3685 J9 INT J EPIDEMIOL JI Int. J. Epidemiol. PY 2015 VL 44 SU 1 MA 3396 BP 227 EP 227 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DM9BV UT WOS:000376659900587 ER PT J AU D'Souza, B Shastri, PN Hammons, G Kolluru, LP Mulla, NS Rajam, G AF D'Souza, Bernadette Shastri, Prathap Nagaraja Hammons, Gabrielle Kolluru, Lakshmi Prasanna Mulla, Nihal S. Rajam, Gowrisankar BE DSouza, MJ TI Microparticulate Formulation for a Pneumococcal Capsular Polysaccharide Antigen SO NANOPARTICULATE VACCINE DELIVERY SYSTEMS LA English DT Article; Book Chapter ID CONJUGATE VACCINE; STREPTOCOCCUS-PNEUMONIAE; ORAL IMMUNIZATION; IMMUNE-RESPONSES; DELIVERY; DISEASE; IMMUNOGENICITY; MICROSPHERES; ANTIBODIES; BURDEN C1 [D'Souza, Bernadette] Samford Univ, McWhorter Sch Pharm, Birmingham, AL USA. [Shastri, Prathap Nagaraja] WIL Res Labs, Ashland, OH USA. [Hammons, Gabrielle; Rajam, Gowrisankar] Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Kolluru, Lakshmi Prasanna] Pharmaforce, New Albany, OH USA. [Mulla, Nihal S.] Mercer Univ, Atlanta, GA USA. RP D'Souza, B (reprint author), Samford Univ, McWhorter Sch Pharm, Birmingham, AL USA. EM bdsouza@samford.edu NR 20 TC 0 Z9 0 U1 0 U2 0 PU PAN STANFORD PUBLISHING PTE LTD PI SINGAPORE PA PENTHOUSE LEVEL, SUNTEC TOWER 3, 8 TEMASEK BLVD, SINGAPORE, 038988, SINGAPORE BN 978-981-4613-31-6 PY 2015 BP 115 EP 126 D2 10.1201/b18096 PG 12 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA BE8HA UT WOS:000376461800006 ER PT J AU Soebiyanto, RP Clara, WA Jara, J Balmaseda, A Lara, J Moya, ML Palekar, R Widdowson, MA Azziz-Baumgartner, E Kiang, RK AF Soebiyanto, Radina P. Clara, Wilfrido A. Jara, Jorge Balmaseda, Angel Lara, Jenny Moya, Mariel Lopez Palekar, Rakhee Widdowson, Marc-Alain Azziz-Baumgartner, Eduardo Kiang, Richard K. TI Associations between seasonal influenza and meteorological parameters in Costa Rica, Honduras and Nicaragua SO GEOSPATIAL HEALTH LA English DT Article DE Influenza; Central America; Rainfall; Temperature; Humidity ID RELATIVE-HUMIDITY; VIRUS; TRANSMISSION; TEMPERATURE; BANGLADESH; CHILDREN AB Seasonal influenza affects a considerable proportion of the global population each year. We assessed the association between sub-national influenza activity and temperature, specific humidity and rainfall in three Central America countries, i.e. Costa Rica, Honduras and Nicaragua. Using virologic data from each country's national influenza centre, rainfall from the Tropical Rainfall Measuring Mission and air temperature and specific humidity data from the Global Land Data Assimilation System, we applied logistic regression methods for each of the five sub-national locations studied. Influenza activity was represented by the weekly proportion of respiratory specimens that tested positive for influenza. The models were adjusted for the potentially confounding co-circulating respiratory viruses, seasonality and previous weeks' influenza activity. We found that influenza activity was proportionally associated (P<0.05) with specific humidity in all locations [odds ratio (OR) 1.21-1.56 per g/kg], while associations with temperature (OR 0.69-0.81 per degrees C) and rainfall (OR 1.01-1.06 per mm/day) were location-dependent. Among the meteorological parameters, specific humidity had the highest contribution (similar to 3-15%) to the model in all but one location. As model validation, we estimated influenza activity for periods, in which the data was not used in training the models. The correlation coefficients between the estimates and the observed were <= 0.1 in 2 locations and between 0.6-0.86 in three others. In conclusion, our study revealed a proportional association between influenza activity and specific humidity in selected areas from the three Central America countries. C1 [Soebiyanto, Radina P.] Univ Space Res Assoc, Goddard Earth Sci Technol & Res, Columbia, MD USA. [Soebiyanto, Radina P.; Kiang, Richard K.] NASA, Global Change Data Ctr, Goddard Space Flight Ctr, Greenbelt, MD USA. [Clara, Wilfrido A.] Ctr Dis Control & Prevent, Influenza Program, Reg Off Cent Amer Reg, Guatemala City, Guatemala. [Jara, Jorge] Univ Valle Guatemala, Influenza Unit, Ctr Hlth Studies, Guatemala City, Guatemala. [Balmaseda, Angel] Minist Hlth Nicaragua, Natl Virol Lab, Managua, Nicaragua. [Lara, Jenny; Moya, Mariel Lopez] Costa Rican Inst Res & Educ Nutr & Hlth, San Jose, Costa Rica. [Palekar, Rakhee] Pan Amer Hlth Org, Washington, DC USA. [Widdowson, Marc-Alain; Azziz-Baumgartner, Eduardo] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. RP Kiang, RK (reprint author), NASA, Goddard Space Flight Ctr, Mail Code 610-2, Greenbelt, MD 20771 USA. EM richard.k.kiang@nasa.gov NR 37 TC 0 Z9 0 U1 0 U2 0 PU UNIV NAPLES FEDERICO II PI NAPLES PA FAC VET MED, DEP PATHOLOGY & ANIMAL HEALTH, VET PARASITOLOGY, VIA DELLA VETERINARIA 1, NAPLES, 80137, ITALY SN 1827-1987 EI 1970-7096 J9 GEOSPATIAL HEALTH JI Geospatial Health PY 2015 VL 10 IS 2 BP 144 EP 151 DI 10.4081/gh.2015.372 PG 8 WC Health Care Sciences & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA DG3YF UT WOS:000372006400006 ER PT J AU Faul, M Sasser, SM Lairet, J Mould-Millman, NK Sugerman, D AF Faul, Mark Sasser, Scott M. Lairet, Julio Mould-Millman, Nee-Kofi Sugerman, David TI Trauma Center Staffing, Infrastructure, and Patient Characteristics that Influence Trauma Center Need SO WESTERN JOURNAL OF EMERGENCY MEDICINE LA English DT Article DE Trauma center; staffing; ICU capacity; neurosurgeons; trauma surgeons; insurance; interfacility transfer ID CENTER DESIGNATION; CENTER VOLUME; CARE; MORTALITY; OUTCOMES; IMPACT; COST; INJURIES; SYSTEM; ACT AB Introduction: The most effective use of trauma center resources helps reduce morbidity and mortality, while saving costs. Identifying critical infrastructure characteristics, patient characteristics and staffing components of a trauma center associated with the proportion of patients needing major trauma care will help planners create better systems for patient care. Methods: We used the 2009 National Trauma Data Bank-Research Dataset to determine the proportion of critically injured patients requiring the resources of a trauma center within each Level I-IV trauma center (n=443). The outcome variable was defined as the portion of treated patients who were critically injured. We defined the need for critical trauma resources and interventions ("trauma center need") as death prior to hospital discharge, admission to the intensive care unit, or admission to the operating room from the emergency department as a result of acute traumatic injury. Generalized Linear Modeling (GLM) was used to determine how hospital infrastructure, staffing Levels, and patient characteristics contributed to trauma center need. Results: Nonprofit Level I and II trauma centers were significantly associated with higher levels of trauma center need. Trauma centers that had a higher percentage of transferred patients or a lower percentage of insured patients were associated with a higher proportion of trauma center need. Hospital infrastructure characteristics, such as bed capacity and intensive care unit capacity, were not associated with trauma center need. A GLM for Level III and IV trauma centers showed that the number of trauma surgeons on staff was associated with trauma center need. Conclusion: Because the proportion of trauma center need is predominantly influenced by hospital type, transfer frequency, and insurance status, it is important for administrators to consider patient population characteristics of the catchment area when planning the construction of new trauma centers or when coordinating care within state or regional trauma systems. C1 [Faul, Mark; Sugerman, David] Ctr Dis Control & Prevent, 4770 Buford Highway, Atlanta, GA 30341 USA. [Sasser, Scott M.; Lairet, Julio] Emory Univ, Dept Emergency Med, Atlanta, GA 30322 USA. [Mould-Millman, Nee-Kofi] Univ Colorado, Dept Emergency Med, Aurora, CO USA. RP Faul, M (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway, Atlanta, GA 30341 USA. EM mfaul@cdc.gov OI Faul, Mark/0000-0002-7683-0348 NR 37 TC 1 Z9 1 U1 0 U2 1 PU WESTJEM PI ORANGE PA C/O SHAHRAM LOTFIPOUR, MD, MPH, 333 CITY BLVD W STE 640, RT 128-01, ORANGE, CA 92868 USA SN 1936-900X EI 1936-9018 J9 WEST J EMERG MED JI West. J. Emerg. Med. PD JAN PY 2015 VL 16 IS 1 BP 98 EP 106 DI 10.5811/westjem.2014.10.22837 PG 9 WC Emergency Medicine SC Emergency Medicine GA DH9IH UT WOS:000373109200018 PM 25671017 ER PT J AU Habel, MA Scheinmann, R Verdesoto, E Gaydos, C Bertisch, M Chiasson, MA AF Habel, Melissa A. Scheinmann, Roberta Verdesoto, Elizabeth Gaydos, Charlotte Bertisch, Maggie Chiasson, Mary Ann TI Exploring pharmacy and home-based sexually transmissible infection testing SO SEXUAL HEALTH LA English DT Article DE emergency contraception; Internet; point-of-care testing; social media; United States ID EMERGENCY HORMONAL CONTRACEPTION; COMMUNITY PHARMACIES; CHLAMYDIA-TRACHOMATIS; TRANSMITTED INFECTIONS; RETAIL CLINICS; COST-EFFECTIVENESS; SCREENING-PROGRAM; STD SERVICES; WOMEN; HEALTH AB Background: This study assessed the feasibility and acceptability of pharmacy and home-based sexually transmissible infection (STI) screening as alternate testing venues among emergency contraception (EC) users. Methods: The study included two phases in February 2011-July 2012. In Phase I, customers purchasing EC from eight pharmacies in Manhattan received vouchers for free STI testing at onsite medical clinics. In Phase II, three Facebook ads targeted EC users to connect them with free home-based STI test kits ordered online. Participants completed a self-administered survey. Results: Only 38 participants enrolled in Phase I: 90% female, <= 29 years (74%), 45% White non-Hispanic and 75% college graduates; 71% were not tested for STIs in the past year and 68% reported a new partner in the past 3 months. None tested positive for STIs. In Phase II, ads led to >45 000 click-throughs, 382 completed the survey and 290 requested kits; 28% were returned. Phase II participants were younger and less educated than Phase I participants; six tested positive for STIs. Challenges included recruitment, pharmacy staff participation, advertising with discretion and cost. Conclusions: This study found low uptake of pharmacy and home-based testing among EC users; however, STI testing in these settings is feasible and the acceptability findings indicate an appeal among younger women for testing in non-traditional settings. Collaborating with and training pharmacy and medical staff are key elements of service provision. Future research should explore how different permutations of expanding screening in non-traditional settings could improve testing uptake and detect additional STI cases. C1 [Habel, Melissa A.] Ctr Dis Control & Prevent, 1600 Clifton Rd,Mailstop E-44, Atlanta, GA USA. [Scheinmann, Roberta; Verdesoto, Elizabeth; Chiasson, Mary Ann] Publ Hlth Solut, New York, NY USA. [Gaydos, Charlotte] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Bertisch, Maggie] New York Walk Med Grp, New York, NY USA. RP Habel, MA (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,Mailstop E-44, Atlanta, GA USA. EM mhabel@cdc.gov FU NIBIB, NIH [U54EB007958]; NIAID NIH [U-01 AI 068] FX Charlotte Gaydos received funding from NIBIB, NIH U54EB007958 and NIAID NIH U-01 AI 068. All other authors have no conflicts of interest to disclose. NR 47 TC 1 Z9 1 U1 0 U2 2 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1448-5028 EI 1449-8987 J9 SEX HEALTH JI Sex Health PY 2015 VL 12 IS 6 BP 472 EP 479 DI 10.1071/SH15031 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA DG0TH UT WOS:000371778100002 PM 26409484 ER PT J AU Woodhall, SC Torrone, L Fine, D Salomon, SG Nakatsukasa-Ono, W Soldan, K Weinstock, H AF Woodhall, Sarah C. Torrone, Lizzi Fine, David Salomon, Sarah G. Nakatsukasa-Ono, Wendy Soldan, Kate Weinstock, Hillard TI How do changes in the population tested for chlamydia over time affect observed trends in chlamydia positivity? Analysis of routinely collected data from young women tested for chlamydia in family planning clinics in the Pacific Northwest (USA), between 2003 and 2010 SO SEXUAL HEALTH LA English DT Article ID UNITED-STATES; INFECTION; IMPACT AB Background: The proportion of chlamydia tests that are positive (positivity) is dependent on the population tested and the test technology used. The way in which changes in these variables might affect trends in positivity over time is investigated. Methods: Data from 15- to 24-year-old women tested for chlamydia in family planning clinics participating in the Infertility Prevention Project in the Pacific Northwest, United States (USA Public Health Service Region X) during 2003-2010 (n = 590 557) were analysed. Trends in positivity and in test, demographic and sexual behaviour variables were identified. Unadjusted and adjusted trends in chlamydia positivity were calculated using logistic regression. Results: The proportion of tests carried out using nucleic acid amplification tests (NAATs) increased dramatically during the analysis period in two states. Smaller changes in demographic and behavioural characteristics were seen. Controlling for test technology used had the largest effect on the trend in testing positive per year, leading to a fall in the calculated odds ratio of testing positive from 1.06 to 1.02 in Oregon, and from 1.07 to 1.02 in Idaho. Controlling for other variables had minimal effect on chlamydia positivity trends. Conclusions: Changes in NAAT use had a large effect on observed trends in chlamydia positivity over time in the two states where NAATs were introduced during the analysis period. While trends in chlamydia positivity may be a useful metric for monitoring chlamydia burden, it is important to consider changes in test type when interpreting these data. C1 [Woodhall, Sarah C.; Soldan, Kate] Publ Hlth England, Ctr Infect Dis Surveillance & Control, HIV & STI Dept, London, England. [Torrone, Lizzi; Weinstock, Hillard] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div STD Prevent, Atlanta, GA USA. [Fine, David; Salomon, Sarah G.; Nakatsukasa-Ono, Wendy] Cardea Serv, Seattle, WA USA. RP Woodhall, SC (reprint author), Publ Hlth England, Ctr Infect Dis Surveillance & Control, HIV & STI Dept, London, England. EM sarah.woodhall@phe.gov.uk FU Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA; Department of Health FX The authors thank the patients and clinics who contributed data. This work was supported by funds from the Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA. At the time of the study, SW and KS worked for the Health Protection Agency (now part of Public Health England), who received funding from the Department of Health. The views expressed in this publication are those of the authors and not necessarily those of the Department of Health. The findings and conclusions in this report do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 13 TC 1 Z9 1 U1 0 U2 1 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1448-5028 EI 1449-8987 J9 SEX HEALTH JI Sex Health PY 2015 VL 12 IS 6 BP 512 EP 519 DI 10.1071/SH15044 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA DG0TH UT WOS:000371778100008 PM 26363873 ER PT J AU Poehlman, J Uhrig, JD Friedman, A Scales, M Forsythe, A Robinson, SJ AF Poehlman, Jon Uhrig, Jennifer D. Friedman, Allison Scales, Monica Forsythe, Ann Robinson, Susan J. TI Bundling of STDs and HIV in Prevention Messages SO JOURNAL OF SOCIAL MARKETING LA English DT Article DE Health promotion; Social marketing theory; Message framing; HIV; STDs; Bundling ID MARKETING-RESEARCH; INTEGRATION; KNOWLEDGE; CDC AB Purpose - This study aims to explore peoples cognitive perceptions of HIV and other sexually transmitted diseases (STDs) to inform decisions on message development with regard to message bundling, with limited research on the concept of bundling-related prevention messages and no studies that consider the bundling of HIV and other STD prevention messages. Design/methodology/approach - Individual and small-group interviews were conducted with 158 African American men and women to explore perceptions of STDs and communication preferences. Open-ended questions and a pile-sort exercise were used to elicit individuals' judgments on similarities of 12 STDs, including HIV. Interview data were coded and analyzed for themes and patterns; pile sort data were analyzed using multidimensional scaling (MDS) and cluster analysis to visualize the set of relations identified from the piles. Findings - STDs and HIV are associated with stigma, risk behaviors and personal responsibility. The card sorting activity revealed two primary dimensions by which people organized STDs: seriousness and curability. Potential clusters of STDs that correspond to participants described sorting strategies were identified and they may have implications for message bundling. Disaggregation of the data by sex and age revealed slight variations in the relationships of HIV and human papillomavirus (HPV) to other STDs. Originality/value - By identifying a set of cognitive attributes people use in organizing the overall semantic domain of STDs, ideas can be generated for how best to combine STD and HIV messages to meet public health communication goals. C1 [Poehlman, Jon; Uhrig, Jennifer D.; Scales, Monica] RTI Int, Hlth Commun, Durham, NC USA. [Friedman, Allison] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA. [Forsythe, Ann] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Robinson, Susan J.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. RP Poehlman, J (reprint author), RTI Int, Hlth Commun, Durham, NC USA. EM jpoehlman@rti.org NR 18 TC 1 Z9 1 U1 1 U2 1 PU EMERALD GROUP PUBLISHING LTD PI BINGLEY PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND SN 2042-6763 EI 2042-6771 J9 J SOC MARKET JI J. Soc. Market. PY 2015 VL 5 IS 1 BP 2 EP 20 DI 10.1108/JSOCM-08-2013-0051 PG 19 WC Business SC Business & Economics GA DF4RN UT WOS:000371338000001 ER PT S AU Dingle, TC MacCannell, DR AF Dingle, Tanis C. MacCannell, Duncan R. BE Sails, A Tang, YW TI Molecular Strain Typing and Characterisation of Toxigenic Clostridium difficile SO CURRENT AND EMERGING TECHNOLOGIES FOR THE DIAGNOSIS OF MICROBIAL INFECTIONS SE Methods in Microbiology LA English DT Review; Book Chapter ID TANDEM-REPEAT ANALYSIS; MULTILOCUS VARIABLE-NUMBER; FIELD GEL-ELECTROPHORESIS; POLYMERASE-CHAIN-REACTION; SEQUENCE-BASED PCR; RESTRICTION-ENDONUCLEASE ANALYSIS; ARBITRARILY PRIMED PCR; REPETITIVE-ELEMENT PCR; DNA RAPD ASSAY; PULSED-FIELD C1 [Dingle, Tanis C.] Icahn Sch Med Mt Sinai, New York, NY 10029 USA. [MacCannell, Duncan R.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. RP MacCannell, DR (reprint author), Ctr Dis Control & Prevent CDC, Atlanta, GA USA. EM dmaccannell@cdc.gov NR 116 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA SN 0580-9517 BN 978-0-12-803297-8 J9 METHOD MICROBIOL JI Methods Microbiol. PY 2015 VL 42 BP 329 EP 357 DI 10.1016/bs.mim.2015.07.001 PG 29 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA BE3BP UT WOS:000370481700010 ER PT J AU Crepaz, N Tungol-Ashmon, MV Vosburgh, HW Baack, BN Mullins, MM AF Crepaz, Nicole Tungol-Ashmon, Malu V. Vosburgh, H. Waverly Baack, Brittney N. Mullins, Mary M. TI Are couple-based interventions more effective than interventions delivered to individuals in promoting HIV protective behaviors? A meta-analysis SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE HIV prevention; couple-based; systematic review; meta-analysis; intervention ID RANDOMIZED CONTROLLED-TRIAL; ANTIRETROVIRAL THERAPY; HETEROSEXUAL COUPLES; DISCORDANT-COUPLES; SEXUAL RISK; PREVENTION; ADHERENCE; EFFICACY; WOMEN; TRANSMISSION AB Despite several advantages to bringing couples together to learn how to protect themselves and new-born children from the risk of HIV infection, most interventions are designed for individuals or groups, not for dyads. This meta-analysis provides a direct test of whether couple-based interventions are more effective in promoting HIV protective behaviors than interventions delivered to individuals. We conducted systematic searches of five electronic databases and 60 journals. Eligible studies were controlled trials or prospective cohort designs; evaluated a couple-based intervention compared to an individual-level intervention; assessed at least one HIV prevention outcome (e.g., protective sex, drug use, HIV testing, medication adherence, and sexually transmitted infections [STI]); and were published between 1988 and 2014. Fifteen interventions, including 21,882 participants from China, Kenya, Rwanda, Tanzania, Trinidad, Zambia, and the USA, were evaluated. The results of random-effects models showed statistically significant intervention effects for protective sex (OR = 1.60, 95% CI = 1.21, 2.11), HIV testing (OR = 1.79, 95% CI = 1.31, 2.45), and Nevirapine uptake (OR = 1.51, 95% CI = 1.02, 2.24). The evidence demonstrates the usefulness of couple-based interventions in protecting individuals, partners, and new-born children from the risk of HIV transmission and infection. C1 [Crepaz, Nicole; Tungol-Ashmon, Malu V.; Vosburgh, H. Waverly; Baack, Brittney N.; Mullins, Mary M.] US Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Crepaz, N (reprint author), US Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. EM ncrepaz@cdc.gov FU Division of HIV/AIDS Prevention at the U.S. Centers for Disease Control and Prevention FX This work was supported by the Division of HIV/AIDS Prevention at the U.S. Centers for Disease Control and Prevention and was not funded by any other organization. NR 31 TC 4 Z9 4 U1 4 U2 4 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 EI 1360-0451 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2015 VL 27 IS 11 BP 1361 EP 1366 DI 10.1080/09540121.2015.1112353 PG 6 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA DD3IA UT WOS:000369814100001 PM 26608175 ER PT J AU Byrd, KK Furtado, M Bush, T Gardner, L AF Byrd, Kathy K. Furtado, Melissa Bush, Tim Gardner, Lytt TI Evaluating patterns in retention, continuation, gaps, and re-engagement in HIV care in a Medicaid-insured population, 2006-2012, United States SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE Retention in care; engagement in care; gap in care; HIV; Medicaid ID ACTIVE ANTIRETROVIRAL THERAPY; RISK-FACTORS; FOLLOW-UP; SURVIVAL; COHORT; SERVICES; HEALTH AB We used the US-based MarketScan (R) Medicaid Multi-state Databases to determine the un-weighted proportion of publically insured persons with HIV that were retained, continued, and re-engaged in care. Persons were followed for up to 84 months. Cox proportional hazards models were conducted to determine factors associated with gaps in care. Of the 6463 HIV cases identified in 2006, 61% were retained during the first 24 months, and 53% continued in care through 78 months. Between 8% and 30% experienced a gap in care, and 59% of persons who experienced a gap in care later re-engaged in care. Persons with one or more Charlson co-morbidities (HR 0.72, 95% CI 0.64-0.81), ages 40-59 (0.79, 0.71-0.88), mental illness diagnosis (0.79, 0.72-0.87), hepatitis C co-infection (0.83, 0.750.93), and female sex (0.86, 0.78-0.94) were less likely to experience a gap in care. Between 27% and 38% of those not retained in care continued to receive HIV-related laboratory services. This Medicaid claims database combines features of both clinic visits-based and surveillance lab-based surrogate measures to give a more complete picture of engagement in care than single-facility-based studies. C1 [Byrd, Kathy K.; Bush, Tim; Gardner, Lytt] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Furtado, Melissa] Engility Corp, Atlanta, GA USA. RP Byrd, KK (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. EM gdn8@cdc.gov NR 23 TC 3 Z9 3 U1 1 U2 3 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 EI 1360-0451 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PY 2015 VL 27 IS 11 BP 1387 EP 1395 DI 10.1080/09540121.2015.1114991 PG 9 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA DD3IA UT WOS:000369814100005 PM 26679267 ER PT J AU Jones, D Marks, G Villar-Loubet, O Weiss, SM O'Daniels, C Borkowf, CB Simpson, C Adimora, AA McLellan-Lemal, E AF Jones, Deborah Marks, Gary Villar-Loubet, Olga Weiss, Stephen M. O'Daniels, Christine Borkowf, Craig B. Simpson, Cathy Adimora, Ada A. McLellan-Lemal, Eleanor TI EXPERIENCE OF FORCED SEX AND SUBSEQUENT SEXUAL, DRUG, AND MENTAL HEALTH OUTCOMES: AFRICAN AMERICAN AND HISPANIC WOMEN IN THE SOUTHEASTERN UNITED STATES SO INTERNATIONAL JOURNAL OF SEXUAL HEALTH LA English DT Article DE Sexual violence; women; cross-cultural studies; HIV prevention; quantitative studies ID INTIMATE PARTNER VIOLENCE; RISK BEHAVIOR; CHILDHOOD ABUSE; HIV-INFECTION; VICTIMIZATION; INTERVENTION; HIV/AIDS; HISTORY; COUPLES; TRAUMA AB Objectives: This cross-sectional study examined African American and Hispanic women's (N = 1,509) self-reports of unwanted forced sex and its association with behavioral and mental health outcomes after the event. Methods: Twenty percent of the women had experienced forced sex (1st occurrence at age 15 years or younger for 10%, 1st occurrence at older than 15 years of age for 10%). Results: Regardless of when forced sex 1st occurred, women were more likely to have engaged in unprotected vaginal and anal sex, to have had multiple unprotected sex partners, to have sexually transmitted infections, to have reported binge drinking and illicit drug use, and to exhibit distress and have received mental health counseling. Conclusions: Forced sex may have wide-ranging behavioral and mental health consequences years later. C1 [Jones, Deborah; Villar-Loubet, Olga; Weiss, Stephen M.] Univ Miami, Psychiat & Behav Sci, Miller Sch Med, Miami, FL 33136 USA. [Marks, Gary; O'Daniels, Christine; Borkowf, Craig B.; McLellan-Lemal, Eleanor] US Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [O'Daniels, Christine] Carter Consulting Inc, Atlanta, GA USA. [Simpson, Cathy] Univ Alabama Birmingham, Sch Publ Hlth, Birmingham, AL 35294 USA. [Adimora, Ada A.] Univ N Carolina, Div Infect Dis, Chapel Hill, NC USA. RP Jones, D (reprint author), Univ Miami, Psychiat & Behav Sci, 1400 NW 10th Ave,404 D-80, Miami, FL 33136 USA. EM djones@med.miami.edu FU Intramural CDC HHS [CC999999]; NIAID NIH HHS [P30 AI073961] NR 48 TC 0 Z9 0 U1 5 U2 7 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1931-7611 EI 1931-762X J9 INT J SEX HEALTH JI Int. J. Sex. Health PY 2015 VL 27 IS 3 BP 249 EP 263 DI 10.1080/19317611.2014.959631 PG 15 WC Psychology, Clinical; Public, Environmental & Occupational Health; Social Sciences, Interdisciplinary SC Psychology; Public, Environmental & Occupational Health; Social Sciences - Other Topics GA DD3SC UT WOS:000369842000008 PM 26380592 ER PT J AU Foote, EM Singleton, RJ Holman, RC Seeman, SM Steiner, CA Bartholomew, M Hennessy, TW AF Foote, Eric M. Singleton, Rosalyn J. Holman, Robert C. Seeman, Sara M. Steiner, Claudia A. Bartholomew, Michael Hennessy, Thomas W. TI Lower respiratory tract infection hospitalizations among American Indian/Alaska Native children and the general United States child population SO INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH LA English DT Article DE pneumonia; epidemiology; American Indian; respiratory; Alaska Native ID INVASIVE PNEUMOCOCCAL DISEASE; WOOD-BURNING STOVES; INFLUENZA-A H1N1; VACCINATION COVERAGE; VIRUS-INFECTION; RISK-FACTORS; US CHILDREN; ALASKA; PNEUMONIA; BRONCHIOLITIS AB Background. The lower respiratory tract infection (LRTI)-associated hospitalization rate in American Indian and Alaska Native (AI/AN) children aged <5 years declined during 1998-2008, yet remained 1.6 times higher than the general US child population in 2006-2008. Purpose. Describe the change in LRTI-associated hospitalization rates for AI/AN children and for the general US child population aged <5 years. Methods. A retrospective analysis of hospitalizations with discharge ICD-9-CM codes for LRTI for AI/AN children and for the general US child population <5 years during 2009-2011 was conducted using Indian Health Service direct and contract care inpatient data and the Nationwide Inpatient Sample, respectively. We calculated hospitalization rates and made comparisons to previously published 1998-1999 rates prior to pneumococcal conjugate vaccine introduction. Results. The average annual LRTI-associated hospitalization rate declined from 1998-1999 to 2009-2011 in AI/AN (35%, p <0.01) and the general US child population (19%, SE: 4.5%, p <0.01). The 2009-2011 AI/AN child average annual LRTI-associated hospitalization rate was 20.7 per 1,000, 1.5 times higher than the US child rate (13.7 95% CI: 12.6-14.8). The Alaska (38.9) and Southwest regions (27.3) had the highest rates. The disparity was greatest for infant ( <1 year) pneumonia -associated and 2009-2010 H1N1 influenza associated hospitalizations. Conclusions. Although the LRTI-associated hospitalization rate declined, the 2009-2011 AI/AN child rate remained higher than the US child rate, especially in the Alaska and Southwest regions. The residual disparity is likely multi-factorial and partly related to household crowding, indoor smoke exposure, lack of piped water and poverty. Implementation of interventions proven to reduce LRTI is needed among AI/AN children. C1 [Foote, Eric M.] Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA. [Singleton, Rosalyn J.] Alaska Native Tribal Hlth Consortium, Div Community Hlth Serv, Anchorage, AK USA. [Singleton, Rosalyn J.; Holman, Robert C.; Hennessy, Thomas W.] Ctr Dis Control & Prevent CDC, Arctic Invest Program, NCEZID, Anchorage, AK 99508 USA. [Seeman, Sara M.] CDC, Div High Consequence Pathogens & Pathol, NCEZID, Atlanta, GA 30333 USA. [Steiner, Claudia A.] Agcy Healthcare Res & Qual, Healthcare Cost & Utilizat Project, Ctr Delivery Org & Markets, Rockville, MD USA. [Bartholomew, Michael] Indian Hlth Serv, Div Epidemiol & Dis Prevent, Rockville, MD USA. RP Singleton, RJ (reprint author), Ctr Dis Control & Prevent CDC, NCEZID, 4055 Tudor Ctr Dr, Anchorage, AK 99508 USA. EM Ris2@cdc.gov NR 53 TC 4 Z9 4 U1 1 U2 4 PU CO-ACTION PUBLISHING PI JARFALLA PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN SN 1239-9736 EI 2242-3982 J9 INT J CIRCUMPOL HEAL JI Int. J. Circumpolar Health PY 2015 VL 74 AR 29256 DI 10.3402/ijch.v74.29256 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DC9ZC UT WOS:000369579100001 PM 26547082 ER PT J AU Ruscio, BA Brubaker, M Glasser, J Hueston, W Hennessy, TW AF Ruscio, Bruce A. Brubaker, Michael Glasser, Joshua Hueston, Will Hennessy, Thomas W. TI One Health - a strategy for resilience in a changing arctic SO INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH LA English DT Review DE Arctic; circumpolar; One Health; infectious disease; climate change; policy; health policy ID INFECTIOUS-DISEASES; CLIMATE-CHANGE; CHALLENGES; IMPACT AB The circumpolar north is uniquely vulnerable to the health impacts of climate change. While international Arctic collaboration on health has enhanced partnerships and advanced the health of inhabitants, significant challenges lie ahead. One Health is an approach that considers the connections between the environment, plant, animal and human health. Understanding this is increasingly critical in assessing the impact of global climate change on the health of Arctic inhabitants. The effects of climate change are complex and difficult to predict with certainty. Health risks include changes in the distribution of infectious disease, expansion of zoonotic diseases and vectors, changing migration patterns, impacts on food security and changes in water availability and quality, among others. A regional network of diverse stakeholder and transdisciplinary specialists from circumpolar nations and Indigenous groups can advance the understanding of complex climate-driven health risks and provide community-based strategies for early identification, prevention and adaption of health risks in human, animals and environment. We propose a regional One Health approach for assessing interactions at the Arctic human-animal-environment interface to enhance the understanding of, and response to, the complexities of climate change on the health of the Arctic inhabitants. C1 [Ruscio, Bruce A.; Glasser, Joshua] US Dept State, Off Int Hlth & Biodef, Bur Oceans & Int Environm & Sci Affairs, 2201 C St NW, Washington, DC 20520 USA. [Brubaker, Michael] Alaska Native Tribal Hlth Consortium, Ctr Climate & Hlth, Anchorage, AK USA. [Hueston, Will] Univ Minnesota, Coll Vet Med, Global Leadership Programs, Ctr Anim Hlth & Food Safety, St Paul, MN 55108 USA. [Hennessy, Thomas W.] Ctr Dis Control & Prevent CDC, Arctic Invest Program, Div Preparedness & Emerging Infect, Natl Ctr Emerging & Zoonot Dis, Atlanta, GA USA. RP Ruscio, BA (reprint author), US Dept State, Off Int Hlth & Biodef, Bur Oceans & Int Environm & Sci Affairs, 2201 C St NW, Washington, DC 20520 USA. EM RuscioBA@State.gov NR 36 TC 0 Z9 0 U1 1 U2 2 PU CO-ACTION PUBLISHING PI JARFALLA PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN SN 1239-9736 EI 2242-3982 J9 INT J CIRCUMPOL HEAL JI Int. J. Circumpolar Health PY 2015 VL 74 AR 27913 DI 10.3402/ijch.v74.27913 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA DC9YH UT WOS:000369577000001 PM 26333722 ER PT J AU Baker, PRA Francis, DP Soares, J Weightman, AL Foster, C AF Baker, P. R. A. Francis, D. P. Soares, J. Weightman, A. L. Foster, C. TI Community wide interventions for increasing physical activity SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review DE Exercise; Program Development; Cities; Cultural Characteristics; Health Plan Implementation [methods]; Health Promotion [methods] ID RANDOMIZED CONTROLLED-TRIAL; HEALTHY HEART PROGRAM; CARDIOVASCULAR-DISEASE PREVENTION; LIFE-STYLE INTERVENTION; VERB(TM) SUMMER SCORECARD; SCHOOL-BASED INTERVENTION; DUTCH OBESITY INTERVENTION; ACTIVITY PROMOTION PROGRAM; SOCIAL MARKETING CAMPAIGN; STANFORD 5-CITY PROJECT AB Background Multi-strategic community wide interventions for physical activity are increasingly popular but their ability to achieve population level improvements is unknown. Objectives To evaluate the effects of community wide, multi-strategic interventions upon population levels of physical activity. Search methods We searched the Cochrane Public Health Group Segment of the Cochrane Register of Studies, The Cochrane Library, MEDLINE, MEDLINE in Process, EMBASE, CINAHL, LILACS, PsycINFO, ASSIA, the British Nursing Index, Chinese CNKI databases, EPPI Centre (DoPHER, TRoPHI), ERIC, HMIC, Sociological Abstracts, SPORTDiscus, Transport Database and Web of Science (Science Citation Index, Social Sciences Citation Index, Conference Proceedings Citation Index). We also scanned websites of the EU Platform on Diet, Physical Activity and Health; Health-Evidence.org; the International Union for Health Promotion and Education; the NIHR Coordinating Centre for Health Technology (NCCHTA); the US Centre for Disease Control and Prevention (CDC) and NICE and SIGN guidelines. Reference lists of all relevant systematic reviews, guidelines and primary studies were searched and we contacted experts in the field. The searches were updated to 16 January 2014, unrestricted by language or publication status. Selection criteria Cluster randomised controlled trials, randomised controlled trials, quasi-experimental designs which used a control population for comparison, interrupted time-series studies, and prospective controlled cohort studies were included. Only studies with a minimum six-month follow up from the start of the intervention to measurement of outcomes were included. Community wide interventions had to comprise at least two broad strategies aimed at physical activity for the whole population. Studies which randomised individuals from the same community were excluded. Data collection and analysis At least two review authors independently extracted the data and assessed the risk of bias. Each study was assessed for the setting, the number of included components and their intensity. The primary outcome measures were grouped according to whether they were dichotomous (per cent physically active, per cent physically active during leisure time, and per cent physically inactive) or continuous (leisure time physical activity time (time spent)), walking (time spent), energy expenditure (as metabolic equivalents or METS)). For dichotomous measures we calculated the unadjusted and adjusted risk difference, and the unadjusted and adjusted relative risk. For continuous measures we calculated percentage change from baseline, unadjusted and adjusted. Main results After the selection process had been completed, 33 studies were included. A total of 267 communities were included in the review (populations between 500 and 1.9 million). Of the included studies, 25 were set in high income countries and eight were in low income countries. The interventions varied by the number of strategies included and their intensity. Almost all of the interventions included a component of building partnerships with local governments or non-governmental organisations (NGOs) (29 studies). None of the studies provided results by socio-economic disadvantage or other markers of equity. However, of those included studies undertaken in high income countries, 14 studies were described as being provided to deprived, disadvantaged or low socio-economic communities. Nineteen studies were identified as having a high risk of bias, 10 studies were unclear, and four studies had a low risk of bias. Selection bias was a major concern with these studies, with only five studies using randomisation to allocate communities. Four studies were judged as being at low risk of selection bias although 19 studies were considered to have an unclear risk of bias. Twelve studies had a high risk of detection bias, 13 an unclear risk and four a low risk of bias. Generally, the better designed studies showed no improvement in the primary outcome measure of physical activity at a population level. All four of the newly included, and judged to be at low risk of bias, studies (conducted in Japan, United Kingdom and USA) used randomisation to allocate the intervention to the communities. Three studies used a cluster randomised design and one study used a stepped wedge design. The approach to measuring the primary outcome of physical activity was better in these four studies than in many of the earlier studies. One study obtained objective population representative measurements of physical activity by accelerometers, while the remaining three low-risk studies used validated self-reported measures. The study using accelerometry, conducted in low income, high crime communities of USA, emphasised social marketing, partnership with police and environmental improvements. No change in the seven-day average daily minutes of moderate to vigorous physical activity was observed during the two years of operation. Some program level effect was observed with more people walking in the intervention community, however this result was not evident in the whole community. Similarly, the two studies conducted in the United Kingdom (one in rural villages and the other in urban London; both using communication, partnership and environmental strategies) found no improvement in the mean levels of energy expenditure per person per week, measured from one to four years from baseline. None of the three low risk studies reporting a dichotomous outcome of physical activity found improvements associated with the intervention. Overall, there was a noticeable absence of reporting of benefit in physical activity for community wide interventions in the included studies. However, as a group, the interventions undertaken in China appeared to have the greatest possibility of success with high participation rates reported. Reporting bias was evident with two studies failing to report physical activity measured at follow up. No adverse events were reported. The data pertaining to cost and sustainability of the interventions were limited and varied. Authors' conclusions Although numerous studies have been undertaken, there is a noticeable inconsistency of the findings in the available studies and this is confounded by serious methodological issues within the included studies. The body of evidence in this review does not support the hypothesis that the multi-component community wide interventions studied effectively increased physical activity for the population, although some studies with environmental components observed more people walking. C1 [Baker, P. R. A.] Queensland Univ Technol, Sch Publ Hlth & Social Work, Inst Hlth & Biomed Innovat, Victoria Pk Rd, Kelvin Grove, Qld 4059, Australia. [Francis, D. P.] Queensland Univ Technol, Sch Publ Hlth & Social Work, Brisbane, Qld 4001, Australia. [Soares, J.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Nutr Phys Act & Obes, Atlanta, GA USA. [Weightman, A. L.] Cardiff Univ, Informat Serv, SURE, Cardiff CF10 3AX, S Glam, Wales. [Foster, C.] Univ Oxford, Nuffield Dept Populat Hlth, British Heart Fdn Hlth Promot Res Grp, Oxford, England. RP Baker, PRA (reprint author), Queensland Univ Technol, Sch Publ Hlth & Social Work, Inst Hlth & Biomed Innovat, Victoria Pk Rd, Kelvin Grove, Qld 4059, Australia. EM p2.baker@qut.edu.au OI Weightman, Alison/0000-0001-5210-3798 FU Health Practitioner Research Scheme: Queensland Health, Australia; Vacation Research Expereince Scheme: Queensland University of Technology, Australia; National Institute for Health Research, Cochrane Review Incentive Scheme, UK FX Internal sources; Health Practitioner Research Scheme 2009 - 2010: Queensland Health, Australia.; $29,000 Australian was provide as a research fellowship supporting the reviewers PB and DF.; Vacation Research Expereince Scheme 2013/2014: Queensland University of Technology, Australia.; $2,000 Scholarship was provided to under-graduate student Ms Yolanda Lovie-Toon who supported the update.; External sources; National Institute for Health Research, Cochrane Review Incentive Scheme, UK.; 5000 pounds sterling for publication of the review by a set deadline (4 February 2011) NR 367 TC 2 Z9 2 U1 18 U2 35 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X EI 1361-6137 J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2015 IS 1 AR CD008366 DI 10.1002/14651858.CD008366.pub3 PG 168 WC Medicine, General & Internal SC General & Internal Medicine GA DB7DX UT WOS:000368675900002 ER PT J AU Smith, J Mulford, C Latzman, NE Tharp, AT Niolon, PH Blachman-Demner, D AF Smith, Jaclyn Mulford, Carrie Latzman, Natasha E. Tharp, Andra Teten Niolon, Phyllis Holditch Blachman-Demner, Dara TI Taking Stock of Behavioral Measures of Adolescent Dating Violence SO JOURNAL OF AGGRESSION MALTREATMENT & TRAUMA LA English DT Article DE adolescent romantic relationships; behavioral measurement; dating violence; relationship aggression ID RANDOMIZED CONTROLLED-TRIAL; INTIMATE PARTNER VIOLENCE; SEXUAL EXPERIENCES SURVEY; PREVENTION PROGRAM; HEALTH; VICTIMIZATION; ABUSE; AGGRESSION; CONFLICT; ALCOHOL AB The past 2 decades have witnessed an increase in dating violence awareness and research. As the field evolves, it is critical to examine the definition and measurement of adolescent dating violence. This article summarizes the behavioral measures of adolescent dating violence used in the field. Based on a review of the literature and federally funded studies, we identified 48 different measures. The most commonly used measures were the Conflict Tactics Scale-2, the Safe Dates Scale, and the Conflict in Adolescent Dating Relationship Inventory, which all examine aspects of psychological, physical, and sexual violence. Researchers also adapted or created their own measures. This article concludes with a discussion of developments for consideration as the field moves forward. C1 [Smith, Jaclyn] Univ Maryland, Criminol & Criminal Justice Dept, College Pk, MD 20742 USA. [Mulford, Carrie; Blachman-Demner, Dara] Natl Inst Justice, Crime Violence & Victimizat Res Div, Off Res & Evaluat, Washington, DC USA. [Latzman, Natasha E.; Tharp, Andra Teten; Niolon, Phyllis Holditch] Ctr Dis Control & Prevent, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. RP Smith, J (reprint author), Univ Maryland, 2220 LeFrak Hall, College Pk, MD 20742 USA. EM jdsmith519@gmail.com NR 72 TC 4 Z9 4 U1 2 U2 7 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1092-6771 EI 1545-083X J9 J AGGRESS MALTREAT T JI J. Aggress. Maltreatment Trauma PY 2015 VL 24 IS 6 BP 674 EP 692 DI 10.1080/10926771.2015.1049767 PG 19 WC Psychology, Clinical; Criminology & Penology; Family Studies; Psychiatry SC Psychology; Criminology & Penology; Family Studies; Psychiatry GA DB7DI UT WOS:000368674300005 ER PT J AU Machado-Ferreira, E Vizzoni, VF Piesman, J Gazeta, GS Soares, CAG AF Machado-Ferreira, Erik Vizzoni, Vinicius Figueiredo Piesman, Joseph Gazeta, Gilberto Salles Gomes Soares, Carlos Augusto TI Bacteria associated with Amblyomma cajennense tick eggs SO GENETICS AND MOLECULAR BIOLOGY LA English DT Article DE Amblyomma cajennense; tick eggs bacteria; Staphylococcus; Ixodidae ID RESISTANT STAPHYLOCOCCUS-AUREUS; DROSOPHILA-C-VIRUS; STENOTROPHOMONAS-MALTOPHILIA; METHICILLIN-RESISTANT; IXODES-RICINUS; ACARI IXODIDAE; SOUTH-AMERICA; SCIURI GROUP; VECTOR; CATTLE AB Ticks represent a large group of pathogen vectors that blood feed on a diversity of hosts. In the Americas, the Ixodidae ticks Amblyomma cajennense are responsible for severe impact on livestock and public health. In the present work, we present the isolation and molecular identification of a group of culturable bacteria associated with A. cajennense eggs from females sampled in distinct geographical sites in southeastern Brazil. Additional comparative analysis of the culturable bacteria from Anocentor nitens, Rhipicephalus sanguineus and Ixodes scapularis tick eggs were also performed. 16S rRNA gene sequence analyses identified 17 different bacterial types identified as Serratia marcescens, Stenotrophomonas maltophilia, Pseudomonas fluorescens, Enterobacter spp., Micrococcus luteus, Ochrobactrum anthropi, Bacillus cereus and Staphylococcus spp., distributed in 12 phylogroups. Staphylococcus spp., especially S. sciuri, was the most prevalent bacteria associated with A. cajennense eggs, occurring in 65% of the samples and also frequently observed infecting A. nitens eggs. S. maltophilia, S. marcescens and B. cereus occurred infecting eggs derived from specific sampling sites, but in all cases rising almost as pure cultures from infected A. cajennense eggs. The potential role of these bacterial associations is discussed and they possibly represent new targets for biological control strategies of ticks and tick borne diseases. C1 [Machado-Ferreira, Erik; Vizzoni, Vinicius Figueiredo; Gomes Soares, Carlos Augusto] Univ Fed Rio de Janeiro, Inst Biol, Dept Genet, Lab Genet Mol Eucariontes & Simbiontes, BR-21941617 Rio De Janeiro, RJ, Brazil. [Vizzoni, Vinicius Figueiredo; Gazeta, Gilberto Salles] Inst Oswaldo Cruz, Lab Referencia Nacl Vetores Riquetsioses, BR-20001 Rio De Janeiro, RJ, Brazil. [Piesman, Joseph] Ctr Dis Control & Prevent, Div Vector Borne Dis, Bacterial Dis Branch, Ft Collins, CO USA. RP Soares, CAG (reprint author), Univ Fed Rio de Janeiro, Inst Biol, Dept Genet, Lab Genet Mol Eucariontes & Simbiontes, Rua Prof Paulo Rocco S Numero, BR-21941617 Rio De Janeiro, RJ, Brazil. EM soares@biologia.ufrj.br RI Soares, Carlos/H-9464-2016; Gazeta, Gilberto/H-6250-2015 OI Soares, Carlos/0000-0001-9058-9266; FU CNPq; CAPES FX This research was financially supported in part by the Brazilian federal agencies CNPq and CAPES. NR 67 TC 0 Z9 0 U1 3 U2 6 PU SOC BRASIL GENETICA PI RIBEIRAO PRET PA RUA CAP ADELMIO NORBET DA SILVA, 736, ALTO DA BOA VISTA, 14025-670 RIBEIRAO PRET, BRAZIL SN 1415-4757 EI 1678-4685 J9 GENET MOL BIOL JI Genet. Mol. Biol. PY 2015 VL 38 IS 4 BP 477 EP 483 DI 10.1590/S1415-475738420150040 PG 7 WC Biochemistry & Molecular Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Genetics & Heredity GA CZ8QK UT WOS:000367364000009 PM 26537602 ER PT J AU Mainous, AG Tanner, RJ Harle, CA Baker, R Shokar, NK Hulihan, MM AF Mainous, Arch G., III Tanner, Rebecca J. Harle, Christopher A. Baker, Richard Shokar, Navkiran K. Hulihan, Mary M. TI Attitudes toward Management of Sickle Cell Disease and Its Complications: A National Survey of Academic Family Physicians SO ANEMIA LA English DT Article ID HEALTH-CARE; HYDROXYUREA; ANEMIA; TRANSFUSIONS; COSTS; RISK AB Objective. Sickle cell disease (SCD) is a disease that requires a significant degree of medical intervention, and family physicians are one potential provider of care for patients who do not have access to specialists. The extent to which family physicians are comfortable with the treatment of and concerned about potential complications of SCD among their patients is unclear. Our purpose was to examine family physician's attitudes toward SCD management. Methods. Data was collected as part of the Council of Academic Family Medicine Educational Research Alliance (CERA) survey in the United States and Canada that targeted family physicians who were members of CERA-affiliated organizations. We examined attitudes regarding management of SCD. Results. Overall, 20.4% of respondents felt comfortable with treatment of SCD. There were significant differences in comfort level for treatment of SCD patients depending on whether or not physicians had patients who had SCD, as well as physicians who had more than 10% African American patients. Physicians also felt that clinical decision support (CDS) tools would be useful for treatment (69.4%) and avoiding complications (72.6%) in managing SCD patients. Conclusions. Family physicians are generally uncomfortable with managing SCD patients and recognize the utility of CDS tools in managing patients. C1 [Mainous, Arch G., III; Tanner, Rebecca J.; Harle, Christopher A.] Univ Florida, Dept Hlth Serv Res Management & Policy, Gainesville, FL 32610 USA. [Mainous, Arch G., III] Univ Florida, Dept Community Hlth & Family Med, Gainesville, FL 32610 USA. [Baker, Richard] Univ Leicester, Dept Hlth Sci, Leicester LE1 6TP, Leics, England. [Shokar, Navkiran K.] Texas Tech Univ, Hlth Sci Ctr El Paso, Dept Family & Community Med, El Paso, TX 79924 USA. [Hulihan, Mary M.] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Mainous, AG (reprint author), Univ Florida, Dept Hlth Serv Res Management & Policy, POB 100195, Gainesville, FL 32610 USA. EM arch.mainous@ufl.edu NR 16 TC 1 Z9 1 U1 2 U2 3 PU HINDAWI PUBLISHING CORP PI NEW YORK PA 315 MADISON AVE 3RD FLR, STE 3070, NEW YORK, NY 10017 USA SN 2090-1267 EI 2090-1275 J9 ANEMIA JI Anemia PY 2015 AR UNSP 853835 DI 10.1155/2015/853835 PG 6 WC Hematology SC Hematology GA CU2FG UT WOS:000363338400001 ER PT S AU Besser, J AF Besser, John BE Jordan, K Dalmasso, M TI Pulsed-Field Gel Electrophoresis for Disease Monitoring and Control SO PULSE FIELD GEL ELECTROPHORESIS: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE PFGE; Subtyping; PulseNet; Surveillance ID RESISTANT STAPHYLOCOCCUS-AUREUS; UNITED-STATES; SURVEILLANCE; OUTBREAK; INFECTIONS; SEPARATION; MINNESOTA AB Pulsed-field gel electrophoresis (PFGE) is the "gold standard" for molecular subtyping and has significant applications in disease monitoring and control programs. This chapter discusses the advantages of PFGE in light of developing technologies such as whole-genome sequencing. C1 [Besser, John] Ctr Dis Control & Prevent, Enter Dis Lab Branch, NCEZID DFWED, MS C03, Atlanta, GA 30333 USA. RP Besser, J (reprint author), Ctr Dis Control & Prevent, Enter Dis Lab Branch, NCEZID DFWED, MS C03, Atlanta, GA 30333 USA. NR 20 TC 0 Z9 1 U1 0 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-4939-2599-5; 978-1-4939-2598-8 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2015 VL 1301 BP 3 EP 7 DI 10.1007/978-1-4939-2599-5_1 D2 10.1007/978-1-4939-2599-5 PG 5 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA BE0PC UT WOS:000366507500002 PM 25862043 ER PT S AU Luquez, C Joseph, LA Maslanka, SE AF Luquez, Carolina Joseph, Lavin A. Maslanka, Susan E. BE Jordan, K Dalmasso, M TI Molecular Subtyping of Clostridium botulinum by Pulsed-Field Gel Electrophoresis SO PULSE FIELD GEL ELECTROPHORESIS: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Pulsed-field gel electrophoresis; Clostridium botulinum; Botulinum toxin-producing clostridia; Subtyping ID STRAINS; DIVERSITY; OUTBREAKS; PROTOCOLS AB Pulsed-field gel electrophoresis (PFGE) has been extensively used to estimate the genetic diversity of Clostridium botulinum. In addition, PFGE is the standard method for investigating foodborne outbreaks associated with various enteric pathogens, including C. botulinum. PFGE can be used to exclude a suspected but not confirmed food source when the patterns of the food and clinical isolates are different. Indistinguishable PFGE patterns may also be useful for linking isolates between patients or to a food source, but results must be interpreted within an epidemiological context to ensure isolates are truly related. Here, we describe a standardized laboratory protocol for molecular subtyping of C. botulinum by PFGE. C1 [Luquez, Carolina; Joseph, Lavin A.; Maslanka, Susan E.] Ctr Dis Control & Prevent, Enter Dis Lab Branch, Atlanta, GA 30333 USA. RP Luquez, C (reprint author), Ctr Dis Control & Prevent, Enter Dis Lab Branch, Atlanta, GA 30333 USA. NR 11 TC 2 Z9 2 U1 1 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-4939-2599-5; 978-1-4939-2598-8 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2015 VL 1301 BP 103 EP 113 DI 10.1007/978-1-4939-2599-5_10 D2 10.1007/978-1-4939-2599-5 PG 11 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA BE0PC UT WOS:000366507500011 PM 25862052 ER PT S AU Jaros, P Dufour, M Gilpin, B Freeman, MM Ribot, EM AF Jaros, Patricia Dufour, Muriel Gilpin, Brent Freeman, Molly M. Ribot, Efrain M. BE Jordan, K Dalmasso, M TI PFGE for Shiga Toxin-Producing Escherichia coli 0157:H7 (STEC 0157) and Non-0157 STEC SO PULSE FIELD GEL ELECTROPHORESIS: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE E. coli; STEC 0157; Non-0157 STEC; PFGE; Standardized protocol; Molecular subtyping; DNA fingerprint; PulseNet ID FIELD GEL-ELECTROPHORESIS; MULTISTATE OUTBREAK; PULSENET; O157-H7; CONSUMPTION; PROTOCOLS AB This chapter describes the procedure of generating pulsed-field gel electrophoresis (PFGE) profiles (DNA fingerprints) of Shiga toxin-producing Escherichia coli 0157:H7 (STEC 0157) and non-0157 STEC strains within 48 h, based on the standardized laboratory protocol developed by the Centers for Disease Control and Prevention, USA. The protocol describes the preparation of agarose plugs containing STEC 0157 and non-0157 STEC cells, the digestion of bacterial DNA in the plugs using restriction endonuclease enzymes, and the electrophoresis conditions to generate the characteristic PFGE profiles of STEC 0157 and non-0157 STEC isolates. C1 [Jaros, Patricia] Massey Univ, Hopkirk Res Inst, Mol Epidemiol & Publ Hlth Lab, Palmerston North, New Zealand. [Dufour, Muriel] Inst Environm Sci & Res Ltd, Enter Reference Lab, Upper Hutt, New Zealand. [Gilpin, Brent] Inst Environm Sci & Res Ltd, Water Grp, Christchurch, New Zealand. [Freeman, Molly M.; Ribot, Efrain M.] Ctr Dis Control & Prevent, Enter Dis Lab Branch, Atlanta, GA USA. RP Jaros, P (reprint author), Massey Univ, Hopkirk Res Inst, Mol Epidemiol & Publ Hlth Lab, Palmerston North, New Zealand. NR 12 TC 1 Z9 2 U1 0 U2 2 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-4939-2599-5; 978-1-4939-2598-8 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2015 VL 1301 BP 171 EP 189 DI 10.1007/978-1-4939-2425-7_15 D2 10.1007/978-1-4939-2599-5 PG 19 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA BE0PC UT WOS:000366507500016 PM 25862057 ER PT J AU Schiff, LB Holland, KM Stone, DM Logan, J Marshall, KJ Martell, B Bartholow, B AF Schiff, Lara B. Holland, Kristin M. Stone, Deborah M. Logan, J. Marshall, Khiya J. Martell, Brandi Bartholow, Brad TI Acute and Chronic Risk Preceding Suicidal Crises Among Middle-Aged Men Without Known Mental Health and/or Substance Abuse Problems An Exploratory Mixed-Methods Analysis SO CRISIS-THE JOURNAL OF CRISIS INTERVENTION AND SUICIDE PREVENTION LA English DT Article DE suicide; crisis; middle-aged; mixed methods; qualitative ID RECENT LIFE EVENTS; PSYCHOLOGICAL AUTOPSY; COMPLETED SUICIDE; PSYCHIATRIC-DISORDER; ADOLESCENT SUICIDE; BEHAVIOR; FAMILY; ADULTS; PSYCHOPATHOLOGY; CHILDHOOD AB Background: Suicides among men aged 35-64 years increased by 27% between 1999 and 2013, yet little research exists to examine the nature of the suicide risk within this population. Many men do not seek help if they have mental health problems and suicides may occur in reaction to stressful circumstances. Aims: We examined the precipitating circumstances of 600 suicides without known mental health or substance abuse (MH/SA) problems and with a recent crisis. Whether these suicides occurred within the context of an acute crisis only or in the context of chronic circumstances was observed. Method: Using data from the National Violent Death Reporting System and employing mixed-methods analysis, we examined the circumstances and context of a census of middle-aged male suicides (n = 600) in seven states between 2005 and 2010. Results: Precipitating circumstances among this group involved intimate partner problems (IPP; 58.3%), criminal/legal problems (50.7%), job/financial problems (22.5%), and health problems (13.5%). Men with IPP and criminal/legal issues were more likely than men with health and/or job/financial issues to experience suicide in the context of an acute crisis only. Conclusion: Suicides occurring in reaction to an acute crisis only or in the context of acute and chronic circumstances lend themselves to opportunities for intervention. Further implications are discussed. C1 [Schiff, Lara B.] Univ Washington, Dept Hematol, Seattle, WA 98195 USA. [Holland, Kristin M.; Stone, Deborah M.; Logan, J.; Marshall, Khiya J.; Martell, Brandi; Bartholow, Brad] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Div Violence Prevent, Atlanta, GA USA. RP Schiff, LB (reprint author), 2829 Franklin Ave E N3, Seattle, WA 98102 USA. EM lara.schiff@gmail.com NR 51 TC 2 Z9 2 U1 4 U2 8 PU HOGREFE & HUBER PUBLISHERS PI GOTTINGEN PA ROHNSWEG 25, D-37085 GOTTINGEN, GERMANY SN 0227-5910 EI 2151-2396 J9 CRISIS JI Crisis PY 2015 VL 36 IS 5 BP 304 EP 315 DI 10.1027/0227-5910/a000329 PG 12 WC Psychiatry; Psychology, Multidisciplinary SC Psychiatry; Psychology GA CY2EI UT WOS:000366221200002 PM 26122257 ER PT J AU Watson, NF Badr, MS Belenky, G Bliwise, DL Buxton, OM Buysse, D Dinges, DF Gangwisch, J Grandner, MA Kushida, C Malhotra, RK Martin, JL Patel, SR Quan, SF Tasali, E Twery, M Croft, JB Maher, E Barrett, JA Thomas, SM Heald, JL AF Watson, Nathaniel F. Badr, M. Safwan Belenky, Gregory Bliwise, Donald L. Buxton, Orfeu M. Buysse, Daniel Dinges, David F. Gangwisch, James Grandner, Michael A. Kushida, Clete Malhotra, Raman K. Martin, Jennifer L. Patel, Sanjay R. Quan, Stuart F. Tasali, Esra Twery, Michael Croft, Janet B. Maher, Elise Barrett, Jerome A. Thomas, Sherene M. Heald, Jonathan L. TI Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society SO JOURNAL OF CLINICAL SLEEP MEDICINE LA English DT Article AB Sleep is essential for optimal health. The American Academy of Sleep Medicine (AASM) and Sleep Research Society (SRS) developed a consensus recommendation for the amount of sleep needed to promote optimal health in adults, using a modified RAND Appropriateness Method process. The recommendation is summarized here. A manuscript detailing the conference proceedings and evidence supporting the final recommendation statement will be published in SLEEP and the Journal of Clinical Sleep Medicine. C1 [Badr, M. Safwan] Univ Washington, Seattle, WA 98195 USA. [Badr, M. Safwan] Wayne State Univ, Detroit, MI USA. [Belenky, Gregory] Washington State Univ, Spokane, WA USA. [Bliwise, Donald L.] Emory Univ, Atlanta, GA 30322 USA. [Buxton, Orfeu M.] Penn State Univ, University Pk, PA 16802 USA. [Buysse, Daniel] Univ Pittsburgh, Pittsburgh, PA USA. [Dinges, David F.; Grandner, Michael A.] Univ Penn, Philadelphia, PA 19104 USA. [Gangwisch, James] Columbia Univ, New York, NY USA. [Kushida, Clete] Stanford Univ, Stanford, CA 94305 USA. [Malhotra, Raman K.] St Louis Univ, St Louis, MO 63103 USA. [Martin, Jennifer L.] Univ Calif Los Angeles, Los Angeles, CA USA. [Patel, Sanjay R.; Quan, Stuart F.] Harvard Univ, Sch Med, Boston, MA USA. [Tasali, Esra] Univ Chicago, Chicago, IL 60637 USA. [Twery, Michael] NHLBI, NIH, Bethesda, MD 20892 USA. [Croft, Janet B.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Maher, Elise] Sleep Disorders Inst, New York, NY USA. [Barrett, Jerome A.; Thomas, Sherene M.; Heald, Jonathan L.] Amer Acad Sleep Med, Darien, IL USA. RP Watson, NF (reprint author), 2510 N Frontage Rd, Darien, IL 60561 USA. EM research@aasmnet.org OI Patel, Sanjay/0000-0002-9142-5172 FU American Academy of Sleep Medicine and Sleep Research Society; Centers for Disease Control and Prevention (CDC) [1U50DP004930-01] FX Funding for this project was provided by the American Academy of Sleep Medicine and Sleep Research Society, and supported by the cooperative agreement number 1U50DP004930-01 from the Centers for Disease Control and Prevention (CDC). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the CDC. NR 4 TC 14 Z9 14 U1 1 U2 2 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 1550-9389 EI 1550-9397 J9 J CLIN SLEEP MED JI J. Clin. Sleep Med. PY 2015 VL 11 IS 6 BP 591 EP 592 AR PII jc-0X231-15 DI 10.5664/jcsm.4758 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA CY3BZ UT WOS:000366284500001 ER PT J AU Watson, NF Badr, MS Belenky, G Bliwise, DL Buxton, OM Buysse, D Dinges, DF Gangwisch, J Grandner, MA Kushida, C Malhotra, RK Martin, JL Patel, SR Quan, SF Tasali, E Twery, M Croft, JB Maher, E Barrett, JA Thomas, SM Heald, JL AF Watson, Nathaniel F. Badr, M. Safwan Belenky, Gregory Bliwise, Donald L. Buxton, Orfeu M. Buysse, Daniel Dinges, David F. Gangwisch, James Grandner, Michael A. Kushida, Clete Malhotra, Raman K. Martin, Jennifer L. Patel, Sanjay R. Quan, Stuart F. Tasali, Esra Twery, Michael Croft, Janet B. Maher, Elise Barrett, Jerome A. Thomas, Sherene M. Heald, Jonathan L. TI Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion SO JOURNAL OF CLINICAL SLEEP MEDICINE LA English DT Article DE sleep duration; consensus; recommendation; adult; health ID ALL-CAUSE MORTALITY; SHORT-TERM STABILITY; BODY-MASS INDEX; GENERAL-POPULATION; YOUNG-ADULTS; INSULIN SENSITIVITY; METABOLIC SYNDROME; COLORECTAL-CANCER; WAKING ACTIVITIES; BREAST-CANCER AB The American Academy of Sleep Medicine and Sleep Research Society recently released a Consensus Statement regarding the recommended amount of sleep to promote optimal health in adults. This paper describes the methodology, background literature, voting process, and voting results for the consensus statement. In addition, we address important assumptions and challenges encountered during the consensus process. Finally, we outline future directions that will advance our understanding of sleep need and place sleep duration in the broader context of sleep health. C1 [Watson, Nathaniel F.] Univ Washington, Seattle, WA 98195 USA. [Badr, M. Safwan] Wayne State Univ, Detroit, MI USA. [Belenky, Gregory] Washington State Univ, Spokane, WA USA. [Bliwise, Donald L.] Emory Univ, Atlanta, GA 30322 USA. [Buxton, Orfeu M.] Penn State Univ, University Pk, PA 16802 USA. [Buysse, Daniel] Univ Pittsburgh, Pittsburgh, PA USA. [Dinges, David F.; Grandner, Michael A.] Univ Penn, Philadelphia, PA 19104 USA. [Gangwisch, James] Columbia Univ, New York, NY USA. [Kushida, Clete] Stanford Univ, Stanford, CA 94305 USA. [Malhotra, Raman K.] St Louis Univ, St Louis, MO 63103 USA. [Martin, Jennifer L.] Univ Calif Los Angeles, Los Angeles, CA USA. [Patel, Sanjay R.; Quan, Stuart F.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Tasali, Esra] Univ Chicago, Chicago, IL 60637 USA. [Twery, Michael] NIH, Natl Heart Lung Blood Inst, Bethesda, MD 20892 USA. [Croft, Janet B.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Maher, Elise] Sleep Disorders Inst, New York, NY USA. [Barrett, Jerome A.; Thomas, Sherene M.; Heald, Jonathan L.] Amer Acad Sleep Med, Darien, CT USA. RP Watson, NF (reprint author), 2510 N Frontage Rd, IL-60561 Darien, Israel. EM research@aasmnet.org OI Patel, Sanjay/0000-0002-9142-5172 FU American Academy of Sleep Medicine and Sleep Research Society; Centers for Disease Control and Prevention (CDC) [1U50DP004930-01] FX Funding for this project was provided by the American Academy of Sleep Medicine and Sleep Research Society, and supported by the cooperative agreement number 1U50DP004930-01 from the Centers for Disease Control and Prevention (CDC). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the CDC. NR 125 TC 10 Z9 10 U1 4 U2 6 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 1550-9389 EI 1550-9397 J9 J CLIN SLEEP MED JI J. Clin. Sleep Med. PY 2015 VL 11 IS 8 BP 931 EP 952 AR PII jc-0X367-15 DI 10.5664/jcsm.4950 PG 22 WC Clinical Neurology SC Neurosciences & Neurology GA CY3EJ UT WOS:000366290900014 ER PT J AU Morgenthaler, TI Croft, JB Dort, LC Loeding, LD Mullington, JM Thomas, SM AF Morgenthaler, Timothy I. Croft, Janet B. Dort, Leslie C. Loeding, Lauren D. Mullington, Janet M. Thomas, Sherene M. TI Development of the National Healthy Sleep Awareness Project Sleep Health Surveillance Questions SO JOURNAL OF CLINICAL SLEEP MEDICINE LA English DT Article DE healthy sleep awareness; Healthy People 2020 ID QUALITY-OF-LIFE; NUTRITION EXAMINATION SURVEY; RESTLESS LEGS SYNDROME; BLACK-AND-WHITE; CORONARY-HEART-DISEASE; COMORBIDITY SURVEY-REPLICATION; PERCEIVED INSUFFICIENT SLEEP; CARDIAC AUTONOMIC FUNCTION; COMMUNITY-DWELLING ADULTS; NIGHT-SHIFT WORK AB Objectives: For the first time ever, as emphasized by inclusion in the Healthy People 2020 goals, sleep health is an emphasis of national health aims. The National Healthy Sleep Awareness Project (NHSAP) was tasked to propose questions for inclusion in the next Behavioral Risk Factor Surveillance System (BRFSS), a survey that includes a number of questions that target behaviors thought to impact health, as a means to measure community sleep health. The total number of questions could not exceed five, and had to include an assessment of the risk for obstructive sleep apnea (OSA). Methods: An appointed workgroup met via teleconference and face-to-face venues to develop an inventory of published survey questions being used to identify sleep health, to develop a framework on which to analyze the strengths and weaknesses of current survey questions concerning sleep, and to develop recommendations for sleep health and disease surveillance questions going forward. Results: The recommendation was to focus on certain existing BRFSS questions pertaining to sleep duration, quality, satisfaction, daytime alertness, and to add to these other BRFSS existing questions to make a modified STOP-BANG questionnaire (minus the N for neck circumference) to assess for risk of OSA. Conclusions: Sleep health is an important dimension of health that has previously received less attention in national health surveys. We believe that 5 questions recommended for the upcoming BRFSS question banks will assist as important measures of sleep health, and may help to evaluate the effectiveness of interventions to improve sleep health in our nation. C1 [Morgenthaler, Timothy I.] Mayo Clin, Rochester, MN USA. [Croft, Janet B.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Dort, Leslie C.] Univ Calgary, Calgary, AB, Canada. [Loeding, Lauren D.; Thomas, Sherene M.] Amer Acad Sleep Med, Darien, IL 60561 USA. [Mullington, Janet M.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. RP Thomas, SM (reprint author), Amer Acad Sleep Med, 2510 N Frontage Rd, Darien, IL 60561 USA. EM sthomas@aasmnet.org FU American Academy of Sleep Medicine and Sleep Research Society; Centers for Disease Control and Prevention (CDC) [1U50DP004930-01] FX This was not an industry supported study. Dr. Morgenthaler and Dr. Croft have indicated no financial conflicts of interest. Dr. Dort is Editor In Chief of the Journal of Dental Sleep Medicine, has received royalties from a patent she holds with MPowRx, and has stock in Zephyr. Dr. Mullington received a travel reimbursement from Merck. Dr. Thomas and Ms. Loeding are employees of the American Academy of Sleep Medicine. Funding for this project was provided by the American Academy of Sleep Medicine and Sleep Research Society, and by the cooperative agreement number 1U50DP004930-01 from the Centers for Disease Control and Prevention (CDC). The findings and conclusions in this report are those of the authors and do not necessarily represent the official views of the CDC. NR 387 TC 1 Z9 1 U1 7 U2 11 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 1550-9389 EI 1550-9397 J9 J CLIN SLEEP MED JI J. Clin. Sleep Med. PY 2015 VL 11 IS 9 BP 1057 EP + AR PII jc-00318-15 DI 10.5664/jcsm.5026 PG 15 WC Clinical Neurology SC Neurosciences & Neurology GA CY3FA UT WOS:000366292600013 PM 26235156 ER PT J AU Kilinc, FS AF Kilinc, F. Selcen TI A Review of Isolation Gowns in Healthcare: Fabric and Gown Properties SO JOURNAL OF ENGINEERED FIBERS AND FABRICS LA English DT Review DE isolation gown; blood borne pathogen; liquid transmission; protective clothing; healthcare ID ENVIRONMENTAL SURFACES; NOSOCOMIAL INFECTIONS; HOSPITAL FABRICS; VACCINIA VIRUS; STRIKE-THROUGH; OPERATING-ROOM; WOOL FABRICS; WHITE COATS; DISSEMINATORS; TRANSMISSION AB The threat of emerging infectious diseases including Ebola hemorrhagic fever, pandemic influenza, avian influenza, Hepatitis B, Hepatitis C, and SARS has highlighted the need for effective personal protective equipment (PPE) to protect healthcare workers (HCWs), patients, and visitors. PPE is a critical component in the hierarchy of controls used to protect HCWs from infectious hazards. HCW PPE may include gowns, respirators, face masks, gloves, eye protection, face shields, and head and shoe coverings. Important research has been conducted in certain areas, such as respirators and protective masks, but studies in other areas, particularly gowns, are scarce. Gowns are identified as the second-most-used piece of PPE, following gloves, in the healthcare setting. According to the Centers for Disease Control and Prevention's Guideline for Isolation Precautions, isolation gowns should be worn to protect HCWs' arms and exposed body areas during procedures and patient-care activities when anticipating contact with clothing, blood, bodily fluids, secretions and excretions. Isolation gowns currently available on the marketplace offer varying resistance to blood and other bodily fluids depending on the type of the material, its impermeability, and wear and tear. While some studies show no benefit of the routine use of isolation gowns, others demonstrate that its use is associated with a reduced infection rate. This paper reviews isolation gowns in healthcare settings, including the fabrics used, gown design and interfaces, as well as critical parameters that affect microorganism and liquid transmission through fabrics. C1 [Kilinc, F. Selcen] Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Pittsburgh, PA 15260 USA. RP Kilinc, FS (reprint author), Natl Personal Protect Technol Lab, Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Pittsburgh, PA 15260 USA. EM fselcen@gmail.com FU Intramural CDC HHS [CC999999] NR 54 TC 0 Z9 0 U1 2 U2 6 PU INDA PI CARY PA PO BOX 1288, CARY, NC 27512-1288 USA SN 1558-9250 J9 J ENG FIBER FABR JI J. Eng. Fiber Fabr. PY 2015 VL 10 IS 3 BP 180 EP 190 PG 11 WC Materials Science, Textiles SC Materials Science GA CY4UW UT WOS:000366405200020 PM 26989351 ER PT J AU Vieira, PM Mederle, N Lobo, ML Imre, K Mederle, O Xiao, LH Darabus, G Matos, O AF Vieira, Patrcia Manuela Mederle, Narcisa Lobo, Maria Luisa Imre, Kalman Mederle, Ovidiu Xiao, Lihua Darabus, Gheorghe Matos, Olga TI Molecular characterisation of Cryptosporidium (Apicomplexa) in children and cattle in Romania SO FOLIA PARASITOLOGICA LA English DT Article DE Cryptosporidium parvum; man; calves; molecular epidemiology; GP60 variability; eastern Europe ID SUBTYPE ANALYSIS; UNITED-STATES; DAIRY-CATTLE; SUS-SCROFA; HUMANS; PARVUM; CALVES; PORTUGAL; FARMS; AGE AB To investigate the transmission of species of Cryptosporidium Tyzzer, 1907 in Timis County, Romania, 48 isolates of Cryptosporidium coccidia from 11 children, 29 calves and eight pigs were characterised by molecular analysis of two loci (SSU rRNA and 60-kDa glycoprotein gene). Overall, 22 isolates were amplified and sequence analyses revealed that all isolates were Cryptosporidium parvum Tyzzer, 1912. Two subtype families were identified, IIa and IId. Subtype IIdA22G1 (n = 4) was the single C. parvum subtype found in children. Subtypes found in calves included IIdA27G1 (n = 8), a novel subtype, IIdA25G1 (n = 5), IIdA22G1 (n = 2), IIdA21G1a (n = 1), and IIaA16G1R1 (n = 1). Subtype IIdA26G1 was found in a pig. These results were significantly different from previous Romanian reports, as the five subtypes of family IId identified in this study were never identified previously in this country. Thus, cattle may be a source of Cryptosporidium infections for humans and the transmission dynamics of C. parvum in Romania is more complex than previously believed. C1 [Vieira, Patrcia Manuela; Lobo, Maria Luisa; Matos, Olga] Univ Nova Lisboa, Inst Higiene & Med Trop, Grp Protozorios Oportunistas VIH & Outros Protozo, Unidade Parasitol Med,CMDT, P-1200 Lisbon, Portugal. [Mederle, Narcisa; Darabus, Gheorghe] Banats Univ Agr Sci & Vet Med Timisoara, Fac Vet Med, Dept Parasitol & Parasit Dis, Timisoara, Romania. [Imre, Kalman] Banats Univ Agr Sci & Vet Med, Fac Vet Med, Dept Food Hyg & Vet Publ Hlth, Timisoara, Romania. [Mederle, Ovidiu] Univ Med & Pharm, Fac Med, Timisoara, Romania. [Xiao, Lihua] Ctr Dis Control & Prevent, Waterborne & Environm Dis, Div Foodborne, Atlanta, GA USA. RP Matos, O (reprint author), Inst Higiene & Med Trop, Rua Junqueira 100, P-1349008 Lisbon, Portugal. EM omatos@ihmt.unl.pt RI Xiao, Lihua/B-1704-2013 OI Xiao, Lihua/0000-0001-8532-2727 NR 27 TC 0 Z9 0 U1 1 U2 1 PU FOLIA PARASITOLOGICA PI CESKE BUDEJOVICE PA BRANISOVSKA 31,, CESKE BUDEJOVICE 370 05, CZECH REPUBLIC SN 0015-5683 EI 1803-6465 J9 FOLIA PARASIT JI Folia Parasitol. PD JAN 1 PY 2015 VL 62 PG 4 WC Parasitology SC Parasitology GA CW2MU UT WOS:000364827200002 ER PT B AU M'ikanatha, NM Iskander, JK AF M'ikanatha, Nkuchia M. Iskander, John K. BE MIkanatha, NM Iskander, JK TI Surveillance as a foundation for infectious disease prevention and control SO Concepts and Methods in Infectious Disease Surveillance LA English DT Editorial Material; Book Chapter C1 [M'ikanatha, Nkuchia M.] Penn Dept Hlth, Harrisburg, PA 17108 USA. [Iskander, John K.] Ctr Dis Control & Prevent, Off Associate Director Sci, Atlanta, GA USA. RP M'ikanatha, NM (reprint author), Penn Dept Hlth, Harrisburg, PA 17108 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP 3 EP 6 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500003 ER PT B AU Horlick, G O'Connor, J AF Horlick, Gail O'Connor, Jean BE MIkanatha, NM Iskander, JK TI The legal basis for public health surveillance SO Concepts and Methods in Infectious Disease Surveillance LA English DT Article; Book Chapter ID PRIVACY; STATE C1 [Horlick, Gail] Ctr Dis Control & Prevent, Off Sci Integr, Atlanta, GA 30333 USA. [O'Connor, Jean] Georgia Dept Publ Hlth, Hlth Promot & Dis Prevent, Atlanta, GA USA. [O'Connor, Jean] Rollins Sch Publ Hlth, Atlanta, GA USA. RP Horlick, G (reprint author), Ctr Dis Control & Prevent, Off Sci Integr, Atlanta, GA 30333 USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP 7 EP 13 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500004 ER PT B AU M'ikanatha, NM Iskander, JK AF M'ikanatha, Nkuchia M. Iskander, John K. BE MIkanatha, NM Iskander, JK TI Concepts and methods in infectious disease surveillance Preface SO Concepts and Methods in Infectious Disease Surveillance LA English DT Editorial Material; Book Chapter C1 [M'ikanatha, Nkuchia M.] Penn Dept Hlth, Harrisburg, PA 17108 USA. [Iskander, John K.] US PHS, Atlanta, GA USA. [Iskander, John K.] Ctr Dis Control & Prevent, Off Associate Director Sci, Atlanta, GA USA. RP M'ikanatha, NM (reprint author), Penn Dept Hlth, Harrisburg, PA 17108 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP XIII EP XIV PG 2 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500002 ER PT B AU Jajosky, RA Ward, J AF Jajosky, Ruth A. Ward, Jennifer BE MIkanatha, NM Iskander, JK TI National, state, and local public health surveillance systems SO Concepts and Methods in Infectious Disease Surveillance LA English DT Article; Book Chapter ID NOTIFIABLE CONDITIONS; UNITED-STATES; DISEASES; RECORDS C1 [Jajosky, Ruth A.] Ctr Dis Control & Prevent, Div Hlth Informat & Surveillance, Ctr Surveillance Epidemiol & Lab Serv, Off Publ Hlth Sci Serv, Atlanta, GA 30333 USA. [Ward, Jennifer] Tennessee Dept Hlth, Communicable & Environm Dis & Emergency Preparedn, Nashville, TN USA. RP Jajosky, RA (reprint author), Ctr Dis Control & Prevent, Div Hlth Informat & Surveillance, Ctr Surveillance Epidemiol & Lab Serv, Off Publ Hlth Sci Serv, Atlanta, GA 30333 USA. NR 48 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP 14 EP 25 PG 12 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500005 ER PT B AU Payne, DC AF Payne, Daniel C. BE MIkanatha, NM Iskander, JK TI Surveillance for vaccine-preventable diseases and immunization SO Concepts and Methods in Infectious Disease Surveillance LA English DT Article; Book Chapter ID NEONATAL ROTAVIRUS INFECTION; YOUNG-CHILDREN; ADVISORY-COMMITTEE; PRACTICES ACIP; UNITED-STATES; INFANTS; GASTROENTERITIS; EFFICACY; DIARRHEA; RECOMMENDATIONS C1 Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Payne, DC (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. NR 24 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP 33 EP 40 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500007 ER PT B AU Harrison, LH Langley, GF AF Harrison, Lee H. Langley, Gayle Fischer BE MIkanatha, NM Iskander, JK TI Population-based surveillance for bacterial infections of public health importance SO CONCEPTS AND METHODS IN INFECTIOUS DISEASE SURVEILLANCE LA English DT Article; Book Chapter ID B STREPTOCOCCAL DISEASE; INVASIVE PNEUMOCOCCAL DISEASE; TOXIC SHOCK SYNDROME; UNITED-STATES; CONJUGATE VACCINE; MENINGOCOCCAL DISEASE; RISK-FACTORS; POLYSACCHARIDE VACCINE; COLLEGE-STUDENTS; AUREUS DISEASE C1 [Harrison, Lee H.] Univ Pittsburgh, Grad Sch Publ Hlth, Infect Dis Epidemiol Res Unit, Div Infect Dis, Pittsburgh, PA 15260 USA. [Harrison, Lee H.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA. [Langley, Gayle Fischer] Ctr Dis Control & Prevent, Resp Dis Branch, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Harrison, LH (reprint author), Univ Pittsburgh, Grad Sch Publ Hlth, Infect Dis Epidemiol Res Unit, Div Infect Dis, Pittsburgh, PA 15260 USA. NR 79 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP 58 EP 68 PG 11 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500009 ER PT B AU Scallan, E Behravesh, CB AF Scallan, Elaine Behravesh, Casey Barton BE MIkanatha, NM Iskander, JK TI Surveillance for foodborne diseases SO Concepts and Methods in Infectious Disease Surveillance LA English DT Article; Book Chapter ID UNITED-STATES; PUBLIC-HEALTH; SALMONELLA; OUTBREAKS; PATHOGENS; PULSENET C1 [Scallan, Elaine] Colorado Sch Publ Hlth, Aurora, CO 80045 USA. [Behravesh, Casey Barton] Ctr Dis Control & Prevent, Outbreak Response & Prevent Branch, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. RP Scallan, E (reprint author), Colorado Sch Publ Hlth, Aurora, CO 80045 USA. NR 25 TC 1 Z9 1 U1 2 U2 2 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP 69 EP 77 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500010 ER PT B AU Pimentel, LC Taylor, EV AF Pimentel, Linda Capewell Taylor, Ethel V. BE MIkanatha, NM Iskander, JK TI Surveillance for zoonotic diseases SO CONCEPTS AND METHODS IN INFECTIOUS DISEASE SURVEILLANCE LA English DT Article; Book Chapter ID EMERGING INFECTIOUS-DISEASES; ESCHERICHIA-COLI O157; UNITED-STATES; HUMAN PLAGUE; CHILDHOOD BRUCELLOSIS; VETERINARY-MEDICINE; YERSINIA-PESTIS; POULTRY WORKERS; INFLUENZA-VIRUS; TOXOCARA SPP. C1 [Pimentel, Linda Capewell] Ctr Dis Control & Prevent, Anim Care & Use Program Off, Off Sci Integr, Off Associate Director Sci, Atlanta, GA 30333 USA. [Taylor, Ethel V.] Ctr Dis Control & Prevent, Hlth Studies Branch, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Pimentel, LC (reprint author), Ctr Dis Control & Prevent, Anim Care & Use Program Off, Off Sci Integr, Off Associate Director Sci, Atlanta, GA 30333 USA. NR 110 TC 0 Z9 0 U1 1 U2 1 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP 92 EP 106 PG 15 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500012 ER PT B AU Church, DR Haney, GA Klevens, M DeMaria, A AF Church, Daniel R. Haney, Gillian A. Klevens, Monina DeMaria, Alfred, Jr. BE MIkanatha, NM Iskander, JK TI Surveillance of viral hepatitis infections SO Concepts and Methods in Infectious Disease Surveillance LA English DT Article; Book Chapter ID C VIRUS-INFECTION; INJECTION-DRUG USERS; NON-B-HEPATITIS; NEW-YORK-CITY; UNITED-STATES; NON-A; RECORD DATA; ANTIGEN; HEALTH; LIVER C1 [Church, Daniel R.; DeMaria, Alfred, Jr.] Massachusetts Dept Publ Hlth, Bur Infect Dis, Hinton State Lab Inst, Jamaica Plain, MA 02130 USA. [Haney, Gillian A.] Massachusetts Dept Publ Hlth, Integrated Surveillance & Informat Serv, Bur Infect Dis, Hinton State Lab Inst, Jamaica Plain, MA USA. [Klevens, Monina] Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, Div Viral Hepatitis, Atlanta, GA USA. RP Church, DR (reprint author), Massachusetts Dept Publ Hlth, Bur Infect Dis, Hinton State Lab Inst, Jamaica Plain, MA 02130 USA. NR 55 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP 107 EP 121 PG 15 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500013 ER PT B AU Torrone, EA Bernstein, KT AF Torrone, Elizabeth A. Bernstein, Kyle T. BE MIkanatha, NM Iskander, JK TI Surveillance for sexually transmitted diseases SO Concepts and Methods in Infectious Disease Surveillance LA English DT Article; Book Chapter ID NEW-YORK-CITY; UNITED-STATES; NEISSERIA-GONORRHOEAE; CHLAMYDIAL INFECTION; TREATMENT-GUIDELINES; HIV TRANSMISSION; NO LONGER; WOMEN; PREVALENCE; HERPES C1 [Torrone, Elizabeth A.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. [Bernstein, Kyle T.] San Francisco Dept Publ Hlth, Appl Res Community Hlth Epidemiol & Surveillance, Populat Hlth Div, San Francisco, CA USA. RP Torrone, EA (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. NR 56 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP 122 EP 131 PG 10 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500014 ER PT B AU Armstrong, LR Miramontes, R AF Armstrong, Lori R. Miramontes, Roque BE MIkanatha, NM Iskander, JK TI Public health surveillance for tuberculosis SO Concepts and Methods in Infectious Disease Surveillance LA English DT Article; Book Chapter ID UNITED-STATES; TRENDS C1 [Armstrong, Lori R.; Miramontes, Roque] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. RP Armstrong, LR (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. NR 56 TC 0 Z9 0 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP 147 EP 159 PG 13 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500016 ER PT B AU Chapman, LE Tyson, JN AF Chapman, Louisa E. Tyson, James N. BE MIkanatha, NM Iskander, JK TI Analysis and interpretation of surveillance data SO Concepts and Methods in Infectious Disease Surveillance LA English DT Article; Book Chapter ID PUBLIC-HEALTH SURVEILLANCE; UNITED-STATES; INFLUENZA C1 [Chapman, Louisa E.] Ctr Dis Control & Prevent, US PHS, Atlanta, GA 30333 USA. [Chapman, Louisa E.] Ctr Dis Control & Prevent, Publ Hlth Surveillance Program Off, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA USA. [Tyson, James N.] Ctr Dis Control & Prevent, Situat Awareness Unit, Div Emergency Operat, Off Publ Hlth Preparedness & Response, Atlanta, GA USA. RP Chapman, LE (reprint author), Ctr Dis Control & Prevent, US PHS, Atlanta, GA 30333 USA. NR 25 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP 163 EP 176 PG 14 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500017 ER PT B AU Eisen, RJ Eisen, L AF Eisen, Rebecca J. Eisen, Lars BE MIkanatha, NM Iskander, JK TI Use of geographic information systems in infectious disease surveillance SO Concepts and Methods in Infectious Disease Surveillance LA English DT Article; Book Chapter ID WEST-NILE-VIRUS; VECTOR-BORNE DISEASES; HUMAN PLAGUE; UNITED-STATES; SPATIAL-ANALYSIS; RISK; UGANDA; EXPOSURE; MODELS; HEALTH C1 [Eisen, Rebecca J.] Ctr Dis Control & Prevent, Div Vectorborne Dis, Ft Collins, CO 80521 USA. [Eisen, Lars] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA. RP Eisen, RJ (reprint author), Ctr Dis Control & Prevent, Div Vectorborne Dis, Ft Collins, CO 80521 USA. NR 39 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, WEST SUSSEX, ENGLAND BN 978-0-470-65939-7; 978-1-118-92864-6 PY 2015 BP 219 EP 229 PG 11 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA BD6GN UT WOS:000362202500022 ER PT S AU Kato, K Ye, XY Calafat, AM AF Kato, Kayoko Ye, Xiaoyun Calafat, Antonia M. BE DeWitt, JC TI PFASs in the General Population SO TOXICOLOGICAL EFFECTS OF PERFLUOROALKYL AND POLYFLUOROALKYL SUBSTANCES SE Molecular and Integrative Toxicology LA English DT Article; Book Chapter DE Biomonitoring; Exposure assessment; PFOA; PFOS ID PERFLUOROOCTANOIC ACID PFOA; HUMAN BREAST-MILK; PERSISTENT ORGANIC POLLUTANTS; DRINKING-WATER TREATMENT; ADULT-BLOOD DONORS; PERFLUORINATED CARBOXYLIC-ACIDS; HEALTH MEASURES SURVEY; SPRAGUE-DAWLEY RATS; MID-OHIO VALLEY; 2 GERMAN CITIES AB Perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been manufactured since the 1950s for use as surface protectants for textiles and leather treatment, as protection additives in food packaging and paper products, and in firefighting foams. Some PFASs are persistent in the environment and in people, and can be transported to remote regions. The main pathways of exposure to PFASs in humans include diet, drinking water, and indoor dust, but predictors of PFASs exposures are not clearly understood. Since 2002, changes in manufacturing practices appear to have reduced exposure to some of these PFASs both in the environment and in people,- but exposure to PFASs is still widespread. We review relevant research published up to the first quarter of 2014 to understand the demographic, geographic, and temporal differences that contribute to general population exposures to PFASs around the world. We also present data on exposures to PFASs in some vulnerable population groups (e.g., pregnant women, infants, young children). C1 [Kato, Kayoko; Ye, Xiaoyun; Calafat, Antonia M.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. RP Calafat, AM (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. EM Aic7@cdc.gov NR 196 TC 1 Z9 1 U1 7 U2 12 PU SPRINGER-VERLAG LONDON LTD PI GODALMING PA SWEETAPPLE HOUSE CATTESHALL RD FARNCOMBE, GODALMING GU7 1NH, SURREY, ENGLAND SN 2168-4219 BN 978-3-319-15518-0; 978-3-319-15517-3 J9 MOLEC INTEGR TOXICOL PY 2015 BP 51 EP 76 DI 10.1007/978-3-319-15518-0_3 D2 10.1007/978-3-319-15518-0 PG 26 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA BD9KE UT WOS:000364811700004 ER PT S AU Hatton, C Bonardi, A Emerson, E Fox, MH Glover, G Krahn, GL Ouellette-Kuntz, H Turner, S AF Hatton, Chris Bonardi, Alexandra Emerson, Eric Fox, Michael H. Glover, Gyles Krahn, Gloria L. Ouellette-Kuntz, Helene Turner, Sue BE Hatton, C Emerson, E TI Health Surveillance and People with Intellectual Disabilities SO INTERNATIONAL REVIEW OF RESEARCH IN DEVELOPMENTAL DISABILITIES, VOL 48: HEALTH DISPARITIES AND INTELLECTUAL DISABILITIES SE International Review of Research in Developmental Disabilities LA English DT Article; Book Chapter ID QUALITY-OF-LIFE; DEVELOPMENTAL-DISABILITIES; MENTAL-RETARDATION; PROXY RESPONDENTS; BRITISH ADULTS; PUBLIC-HEALTH; DISPARITIES; CARE; PREVALENCE; POPULATION AB In this chapter we use three case studies (from the USA, Canada, and England) to frame a discussion of key conceptual and methodological issues associated with health-surveillance programs for people with intellectual disabilities. These include the challenges associated with (1) identifying people with intellectual disabilities in administrative databases; (2) identifying people with intellectual disabilities inpopulation-based surveys through data linkage and cognitive testing and self-or informant report; (3) sampling issues; (4) the use of specific intellectual disability surveys; and (5) challenges in measuring health. We conclude with a discussion of the relationship between health surveillance and health policy. C1 [Hatton, Chris; Emerson, Eric] Univ Lancaster, Ctr Disabil Res, Lancaster, Lancs, England. [Bonardi, Alexandra] Univ Massachusetts, Sch Med, CDDER, EK Shriver Ctr, Boston, MA 02125 USA. [Bonardi, Alexandra] HSRI, Cambridge, MA USA. [Emerson, Eric] Univ Sydney, Ctr Disabil Res & Policy, Sydney, NSW 2006, Australia. [Fox, Michael H.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Glover, Gyles] Publ Hlth England, Learning Disabil Team, London, England. [Krahn, Gloria L.] Oregon State Univ, Coll Publ Hlth & Human Sci, Corvallis, OR 97331 USA. [Ouellette-Kuntz, Helene] Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada. [Ouellette-Kuntz, Helene] Ongwanada, Kingston, ON, Canada. [Turner, Sue] Natl Dev Team Inclus, Bath, Avon, England. RP Hatton, C (reprint author), Univ Lancaster, Ctr Disabil Res, Lancaster, Lancs, England. EM chris.hatton@lancaster.ac.uk NR 146 TC 0 Z9 0 U1 5 U2 11 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA SN 2211-6095 BN 978-0-12-802484-3; 978-0-12-802291-7 J9 INT REV RES DEV DISA JI Int. Rev. Res. Dev. Disabil. PY 2015 VL 48 BP 73 EP 114 DI 10.1016/bs.irrdd.2015.04.002 PG 42 WC Education, Special; Psychology, Multidisciplinary SC Education & Educational Research; Psychology GA BD7MZ UT WOS:000363327500005 ER PT J AU Ferriola, D Duke, J Huynh, A Gasiewski, A Rogers, M Slavich, L McLaughlin, L Jennings, L Bettinotti, M Kalman, L Monos, D AF Ferriola, Deborah Duke, Jamie Huynh, Anh Gasiewski, Alison Rogers, Marianne Slavich, Larissa McLaughlin, Laura Jennings, Larry Bettinotti, Maria Kalman, Lisa Monos, Dimitri TI ENHANCED CHARACTERIZATION OF 109 GENOMIC DNA REFERENCE MATERIAL FOR 6 HLA LOCI BY NEXT-GENERATION SEQUENCING (NGS) SO HUMAN IMMUNOLOGY LA English DT Meeting Abstract CT 41st Annual Meeting of the American-Society-for-Histocompatibility-and-Immunogenetics (ASHI) CY SEP 28-OCT 02, 2015 CL Savannah, GA SP Amer Soc Histocompatibil & Immunogenet C1 [Ferriola, Deborah; Duke, Jamie; Huynh, Anh; Gasiewski, Alison; Rogers, Marianne; Slavich, Larissa; McLaughlin, Laura; Monos, Dimitri] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA. [Jennings, Larry] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA. [Bettinotti, Maria] Johns Hopkins Sch Med, Baltimore, MD USA. [Kalman, Lisa] Ctr Dis Control & Prevent, Atlanta, GA USA. [Monos, Dimitri] Univ Penn, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0198-8859 EI 1879-1166 J9 HUM IMMUNOL JI Hum. Immunol. PY 2015 VL 76 SU 1 MA P048 BP 70 EP 70 PG 1 WC Immunology SC Immunology GA CT7NH UT WOS:000363001300093 ER PT B AU Heymann, DL West, A AF Heymann, David L. West, Alison BE Rushton, S Youde, J TI EMERGING INFECTIONS Threats to health and economic security SO ROUTLEDGE HANDBOOK OF GLOBAL HEALTH SECURITY LA English DT Article; Book Chapter C1 [Heymann, David L.; West, Alison] Chatham House, Ctr Global Hlth Secur, London, England. [Heymann, David L.] London Sch Hyg & Trop Med, Infect Dis Epidemiol, London, England. [Heymann, David L.] WHO, San Francisco, CA USA. [Heymann, David L.] US Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [West, Alison] Organizing Amer & Democrats Washington, Washington, DC USA. RP Heymann, DL (reprint author), Advisory Board Publ Hlth England, London, England. NR 7 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI ABINGDON PA 2 PARK SQ, MILTON PARK, ABINGDON OX14 4RN, OXFORD, ENGLAND BN 978-0-203-07856-3; 978-0-415-64547-8 PY 2015 BP 92 EP 104 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BD5BB UT WOS:000361310300009 ER PT J AU Evans, DE Fent, KW AF Evans, Douglas E. Fent, Kenneth W. TI Ultrafine and respirable particle exposure during vehicle fire suppression SO ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS LA English DT Article ID CORONARY-HEART-DISEASE; SHORT-TERM EXPOSURE; AIR-POLLUTION; CARBON-MONOXIDE; PSYCHOLOGICAL RESPONSES; CANCER INCIDENCE; UNITED-STATES; FIREFIGHTERS; MORTALITY; ASSOCIATION AB Vehicle fires are a common occurrence, yet few studies have reported exposures associated with burning vehicles. This article presents an assessment of firefighters' potential for ultrafine and respirable particle exposure during vehicle fire suppression training. Fires were initiated within the engine compartment and passenger cabins of three salvaged vehicles, with subsequent water suppression by fire crews. Firefighter exposures were monitored with an array of direct reading particle and air quality instruments. A flexible metallic duct and blower drew contaminants to the instrument array, positioned at a safe distance from the burning vehicles, with the duct inlet positioned at the nozzle operator's shoulder. The instruments measured the particle number, active surface area, respirable particle mass, photoelectric response, aerodynamic particle size distributions, and air quality parameters. Although vehicle fires were suppressed quickly (<10 minutes), firefighters may be exposed to short duration, high particle concentration episodes during fire suppression, which are orders of magnitude greater than the ambient background concentration. A maximum transient particle concentration of 1.21 x 10(7) particles per cm(3), 170 mg m(-3) respirable particle mass, 4700 mm(2) cm(-3) active surface area and 1400 (arbitrary units) in photoelectric response were attained throughout the series of six fires. Expressed as fifteen minute timeweighted averages, engine compartment fires averaged 5.4 x 10(4) particles per cm(3), 0.36 mg m(-3) respirable particle mass, 92 mm(2) cm(-3) active particle surface area and 29 (arbitrary units) in photoelectric response. Similarly, passenger cabin fires averaged 2.04 x 10(5) particles per cm(3), 2.7 mg m(-3) respirable particle mass, 320 mm(2) cm(-3) active particle surface area, and 34 (arbitrary units) in photoelectric response. Passenger cabin fires were a greater potential source of exposure than engine compartment fires. The wind direction and the relative position of the fire crew to the stationary burning vehicle played a primary role in fire crews' potential for exposure. We recommend that firefighters wear self-contained breathing apparatus during all phases of the vehicle fire response to significantly reduce their potential for particulate, vapor, and gaseous exposures. C1 [Evans, Douglas E.] NIOSH, Chem Exposure & Monitoring Branch, Div Appl Res & Technol, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Fent, Kenneth W.] NIOSH, Hazard Evaluat & Tech Assistance Branch, Div Surveillance Hazard Evaluat & Field Studies, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Evans, DE (reprint author), NIOSH, Chem Exposure & Monitoring Branch, Div Appl Res & Technol, Ctr Dis Control & Prevent, 1090 Tusculum Ave,MS R-7, Cincinnati, OH 45226 USA. EM dje3@cdc.gov FU small municipal fire department within SouthWest Ohio FX The authors are grateful to James Couch, Manny Rodriguez, Chad Dowell and Donald Booher for technical assistance during the study and to Fariba Nourian, Charles Urban and Amanda Harney for photography, videography and health communication assistance. The authors acknowledge Paul Baron (deceased), Thomas Hales and Travis Kubale for numerous insightful discussions and Kevin Dunn, Kenneth Mead and Jerry Kratzer for assistance with the duct and blower system. The authors wish to thank Matthew Dahm, Thomas Hales, John Snawder and the anonymous reviewers at the journal for their technical review and helpful comments with this manuscript. The cooperation and support of the small municipal fire department within SouthWest Ohio, who participated in this evaluation, was greatly appreciated. NR 51 TC 0 Z9 0 U1 1 U2 10 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 2050-7887 EI 2050-7895 J9 ENVIRON SCI-PROC IMP JI Environ. Sci.-Process Impacts PY 2015 VL 17 IS 10 BP 1749 EP 1759 DI 10.1039/c5em00233h PG 11 WC Chemistry, Analytical; Environmental Sciences SC Chemistry; Environmental Sciences & Ecology GA CS9RN UT WOS:000362429000005 PM 26308547 ER PT J AU Colborn, JM Ylostalo, JH Koita, OA Cisse, OH Krogstad, DJ AF Colborn, James M. Yloestalo, Joni H. Koita, Ousmane A. Cisse, Ousmane H. Krogstad, Donald J. TI Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria SO JOURNAL OF IMMUNOLOGY RESEARCH LA English DT Article ID TUMOR-NECROSIS-FACTOR; CEREBRAL MALARIA; OLIGONUCLEOTIDE ARRAYS; APOPTOSIS; MICROARRAY; RESPONSES; PATHOGENESIS; INDUCTION; MECHANISM; INFECTION AB To examine human gene expression during uncomplicated P. falciparum malaria, we obtained three samples (acute illness, treatment, and recovery) from 10 subjects and utilized each subject's recovery sample as their baseline. At the time of acute illness (day 1), subjects had upregulation of innate immune response, cytokine, and inflammation-related genes (IL-1 beta, IL-6, TNF, and IFN-gamma), which was more frequent with parasitemias >100,000 per mu L and body temperatures >= 39 degrees C. Apoptosis-related genes (Fas, BAX, and TP53) were upregulated acutely and for several days thereafter (days 1-3). In contrast, the expression of immune-modulatory (transcription factor 7, HLV-DOA, and CD6) and apoptosis inhibitory (c-myc, caspase 8, and Fas Ligand G) genes was downregulated initially and returned to normal with clinical recovery (days 7-10). These results indicate that the innate immune response, cytokine, and apoptosis pathways are upregulated acutely in uncomplicated malaria with concomitant downregulation of immune-modulatory and apoptosis inhibitory genes. C1 [Colborn, James M.; Krogstad, Donald J.] Tulane Univ, Hlth Sci Ctr, Ctr Infect Dis, New Orleans, LA 70112 USA. [Colborn, James M.; Krogstad, Donald J.] Tulane Univ, Hlth Sci Ctr, Dept Trop Med, New Orleans, LA 70112 USA. [Colborn, James M.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Yloestalo, Joni H.] Tulane Univ, Hlth Sci Ctr, Ctr GeneTherapy, New Orleans, LA 70112 USA. [Yloestalo, Joni H.] Univ Mary Hardin Baylor, Dept Biol, Belton, TX 76513 USA. [Koita, Ousmane A.; Cisse, Ousmane H.] Univ Bamako, Fac Sci, Bamako, Mali. [Koita, Ousmane A.; Cisse, Ousmane H.] Univ Bamako, Fac Technol, Bamako, Mali. [Koita, Ousmane A.; Cisse, Ousmane H.] Univ Bamako, Fac Med, Bamako, Mali. [Koita, Ousmane A.; Cisse, Ousmane H.] Univ Bamako, Fac Pharm, Bamako, Mali. [Koita, Ousmane A.; Cisse, Ousmane H.] Univ Bamako, Fac Odontostomatol, Bamako, Mali. [Cisse, Ousmane H.] Univ Lausanne, Inst Microbiol, CH-1011 Lausanne, Switzerland. [Krogstad, Donald J.] Tulane Univ, Hlth Sci Ctr, Dept Med, New Orleans, LA 70112 USA. RP Krogstad, DJ (reprint author), Tulane Univ, Hlth Sci Ctr, Ctr Infect Dis, New Orleans, LA 70112 USA. EM donkrogstad@gmail.com OI Cisse, Ousmane/0000-0002-2990-2185 FU Emerging Infectious Diseases Program of the Centers for Disease Control and Prevention [CCU/UR3 418652, U01 CI 000211]; Tulane University Research Enhancement Award FX The authors thank Fawaz Mzayek for his help in planning and performing the statistical analyses and Barbara Beckman, Frank B. Cogswell, Kaushal Deepak, Elizabeth Didier, Marcelo Kuroda, Michelle Lacey, Frances J. Mather, Tunika I. Okatcha, Sudesh Srivastav, and Young Hong for their thoughtful reviews of the paper. These studies were supported by the Emerging Infectious Diseases Program of the Centers for Disease Control and Prevention (Cooperative Agreements CCU/UR3 418652 and U01 CI 000211) and by a Tulane University Research Enhancement Award to DJK. NR 43 TC 0 Z9 0 U1 0 U2 0 PU HINDAWI PUBLISHING CORP PI NEW YORK PA 315 MADISON AVE 3RD FLR, STE 3070, NEW YORK, NY 10017 USA SN 2314-8861 EI 2314-7156 J9 J IMMUNOL RES JI J Immunol. Res. PY 2015 AR 162639 DI 10.1155/2015/162639 PG 10 WC Immunology SC Immunology GA CT4PA UT WOS:000362787800001 ER PT J AU Forrester, JD Brett, M Matthias, J Stanek, D Springs, CB Marsden-Haug, N Oltean, H Baker, JS Kugeler, KJ Mead, PS Hinckley, A AF Forrester, Joseph D. Brett, Meghan Matthias, James Stanek, Danielle Springs, Chasisity Brown Marsden-Haug, Nicola Oltean, Hanna Baker, JoDee Summers Kugeler, Kiersten J. Mead, Paul S. Hinckley, Alison TI Epidemiology of Lyme disease in low-incidence states SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE Lyme disease; Borrelia burgdorferi; Misdiagnosis ID UNITED-STATES AB Lyme disease is the most common vector-borne disease in the U.S. Surveillance data from four states with a low-incidence of Lyme disease was evaluated. Most cases occurred after travel to high-incidence Lyme disease areas. Cases without travel-related exposure in low-incidence states differed epidemiologically; misdiagnosis may be common in these areas. Published by Elsevier GmbH. C1 [Forrester, Joseph D.; Brett, Meghan] Epidem Intelligence Serv Program, Tallahassee, FL USA. [Forrester, Joseph D.; Brett, Meghan; Kugeler, Kiersten J.; Mead, Paul S.; Hinckley, Alison] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div Vector Borne Dis, Bacterial Dis Branch, Atlanta, GA USA. [Matthias, James; Stanek, Danielle] Florida Dept Hlth, Tallahassee, FL USA. [Springs, Chasisity Brown] S Carolina Dept Hlth & Environm Control, Columbia, SC 29201 USA. [Marsden-Haug, Nicola; Oltean, Hanna] Washington State Dept Hlth, Off Communicable Dis Epidemiol, Washington, DC USA. [Oltean, Hanna] CDC, CSTE Appl Epidemiol Fellowship Program, Ft Collins, CO 80521 USA. [Baker, JoDee Summers] Utah Dept Hlth, Div Dis Control & Prevent, Salt Lake City, UT 84116 USA. RP Forrester, JD (reprint author), CDC, Bacterial Dis Branch, 3156 Rampart Rd, Ft Collins, CO 80521 USA. EM xdd2@cdc.gov; cue0@cdc.gov FU Centers for Disease Control and Prevention (CDC) [1U380T000143-02] FX This study was supported in part by an appointment to the Applied Epidemiology Fellowship Program administered by the Council of State and Territorial Epidemiologists (CSTE) and funded by the Centers for Disease Control and Prevention (CDC) Cooperative Agreement Number 1U380T000143-02. NR 15 TC 3 Z9 3 U1 2 U2 4 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2015 VL 6 IS 6 BP 721 EP 723 DI 10.1016/j.ttbdis.2015.06.005 PG 3 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA CS5UM UT WOS:000362143800005 PM 26103924 ER PT J AU Williams-Newkirk, AJ Burroughs, M Changayil, SS Dasch, GA AF Williams-Newkirk, Amanda J. Burroughs, Mark Changayil, Shankar S. Dasch, Gregory A. TI The mitochondrial genome of the lone star tick (Amblyomma americanum) SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE Ixodid; Heteroplasmy; Phylogenetics; Mitochondria ID RIBOSOMAL-RNA GENES; POPULATION-GENETICS; ACARI IXODIDAE; PHYLOGENETIC ANALYSIS; UNITED-STATES; GENUS AMBLYOMMA; CODON USAGE; HARD TICKS; ARTHROPODS; EVOLUTION AB Amblyomma americanum is an abundant tick in the southeastern, midwestern, and northeastern United States. It is a vector of multiple diseases, but limited genomic resources are available for it. We sequenced the complete mitochondrial genome of a single female A. americanum collected in Georgia using the Illumina platform. The consensus sequence was 14,709 bp long, and the mean coverage across the assembly was >12,000x. All expected tick genomic features were present, including two "Tick-Box" motifs, and in the expected order for the Metastriata. Heteroplasmy rates were low compared to the most closely related tick for which data are available, Amblyomma cajennense. The phylogeny derived from the concatenated protein coding and rRNA genes from the 33 available tick mitochondrial genomes was consistent with those previously proposed for the Acari. This is the first complete mitochondrial sequence for A. americanum, which provides a useful reference for future studies of A. americanum population genetics and tick phylogeny. (C) 2015 Elsevier GmbH. All rights reserved. C1 [Williams-Newkirk, Amanda J.; Dasch, Gregory A.] US Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. [Williams-Newkirk, Amanda J.] Emory Univ, Grad Program Populat Biol Ecol & Evolut, Atlanta, GA 30322 USA. [Williams-Newkirk, Amanda J.] Emory Univ, Dept Environm Sci, Atlanta, GA 30322 USA. [Williams-Newkirk, Amanda J.] Emory Univ, Dept Environm Hlth, Atlanta, GA 30322 USA. [Burroughs, Mark] US Ctr Dis Control & Prevent, Biotechnol Core Facil Branch, Atlanta, GA 30333 USA. [Changayil, Shankar S.] US Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Williams-Newkirk, AJ (reprint author), US Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MailStop G-13, Atlanta, GA 30333 USA. EM IGY7@CDC.GOV FU Oak Ridge Institute for Science and Education (ORISE-CDC); Association of Public Health Laboratories (Bioinformatics-CDC); National Institutes of Health Training Grant (Population Biology Ecology and Evolution Program-Emory University) [T32AI055404] FX Many thanks to Maria Zambrano of the Rickettsial Zoonoses Branch at CDC for her assistance with Sanger sequencing and to A. Michael Frace of the Biotechnology Core Facility Branch at CDC for providing access to the Illumina sequencer used for this project. Primer synthesis and quality control was kindly performed by the CDC Biotechnology Core Facility. This research was funded in part by the appointment of AJW to fellowship positions through the Oak Ridge Institute for Science and Education (ORISE-CDC), Association of Public Health Laboratories (Bioinformatics-CDC), and a National Institutes of Health Training Grant (Population Biology Ecology and Evolution Program-Emory University, grant number T32AI055404). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the US Centers for Disease Control and Prevention or the Department of Health and Human Services. NR 60 TC 2 Z9 2 U1 0 U2 7 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2015 VL 6 IS 6 BP 793 EP 801 DI 10.1016/j.ttbdis.2015.07.006 PG 9 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA CS5UM UT WOS:000362143800016 PM 26189992 ER PT J AU Pornwiroon, W Bourchookarn, A Paddock, CD Macaluso, KR AF Pornwiroon, Walairat Bourchookarn, Apichai Paddock, Christopher D. Macaluso, Kevin R. TI Immunoproteomic profiling of Rickettsia parkeri and Rickettsia amblyommii SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE Rickettsia parkeri; Rickettsia amblyommii; Amblyomma spp.; Immunoproteomic analysis ID MOUNTAIN-SPOTTED-FEVER; GULF-COAST TICKS; OUTER-MEMBRANE PROTEIN; 2-DIMENSIONAL GEL-ELECTROPHORESIS; NEWLY RECOGNIZED CAUSE; UNITED-STATES; PROTEOMIC ANALYSIS; MASS-SPECTROMETRY; VIRULENCE FACTORS; FRANCISELLA-TULARENSIS AB Rickettsia parkeri is an Amblyomma-associated, spotted fever group Rickettsia species that causes an eschar-associated, febrile illness in multiple countries throughout the Western Hemisphere. Many other rickettsial species of known or uncertain pathogenicity have been detected in Amblyomma spp. ticks in the Americas, including Rickettsia ambiyommii, "Candidatus Rickettsia andeanae" and Rickettsia rickettsii. In this study, we utilized an immunoproteomic approach to compare antigenic profiles of low-passage isolates of R. parkeri and R. amblyommii with serum specimens from patients with PCR- and culture-confirmed infections with R. parkeri. Five immunoreactive proteins of R. amblyommii and nine immunoreactive proteins of R. parkeri were identified by matrix-assisted laser desorption ionization tandem time-of-flight mass spectrometry. Four of these, including the outer membrane protein (Omp) A, OmpB, translation initiation factor IF-2, and cell division protein FtsZ, were antigens common to both rickettsiae. Serum specimens from patients with R. parkeri rickettsiosis reacted specifically with cysteinyl-tRNA synthetase, DNA-directed RNA polymerase subunit alpha, putative sigma (54) modulation protein, chaperonin GroEL, and elongation factor Tu of R. parkeri which have been reported as virulence factors in other bacterial species. Unique antigens identified in this study may be useful for further development of the better serological assays for diagnosing infection caused by R. parkeri. (C) 2015 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). C1 [Pornwiroon, Walairat; Macaluso, Kevin R.] Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Baton Rouge, LA 70803 USA. [Pornwiroon, Walairat] Prince Songkla Univ, Fac Sci & Technol, Dept Sci, Muang 94000, Pattani, Thailand. [Bourchookarn, Apichai] Prince Songkla Univ, Fac Sci & Technol, Dept Technol & Ind, Muang 94000, Pattani, Thailand. [Paddock, Christopher D.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. RP Pornwiroon, W (reprint author), Prince Songkla Univ, Fac Sci & Technol, Dept Sci, 181 Rusamilae, Muang 94000, Pattani, Thailand. EM walairat.p@psu.ac.th FU National Institutes of Health (NIH) from the INBRE Program of the National Center for Research Resources [P20 RR-016464]; NIH [P20 RR0201595, AI77784]; National Institute of Allergy and Infectious Diseases [AI070705] FX We thank Dr. Robert F. Massung (Centers for Disease Control and Prevention, Atlanta, GA) for providing patient sera and P. Sunyakumthorn and J. A. Macaluso for helpful comments. Protein identification at the Nevada Proteomics Center, University of Nevada, Reno was supported by the National Institutes of Health (NIH) Grant Number P20 RR-016464 from the INBRE Program of the National Center for Research Resources. This research was supported by NIH (P20 RR0201595, AI77784), and the National Institute of Allergy and Infectious Diseases (AI070705). NR 60 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2015 VL 6 IS 6 BP 829 EP 835 DI 10.1016/j.ttbdis.2015.07.012 PG 7 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA CS5UM UT WOS:000362143800021 PM 26234571 ER PT J AU Gray, J Dantas-Torres, F Estrada-Pena, A Levin, M AF Gray, Jeremy Dantas-Torres, Filipe Estrada-Pena, Agustin Levin, Michael TI Systematics and ecology of the brown dog tick, Rhipicephalus sanguineus (vol 4, pg 171, 2013) SO TICKS AND TICK-BORNE DISEASES LA English DT Correction C1 [Gray, Jeremy] Univ Coll Dublin, Sch Biol & Environm Sci, Dublin 4, Ireland. [Dantas-Torres, Filipe] Fundacao Oswaldo Cruz, Aggeu Magalhaes Res Ctr, Dept Immunol, BR-50670420 Recife, PE, Brazil. [Dantas-Torres, Filipe] Univ Bari, Dept Vet Med, Fac Vet Med, I-70010 Valenzano, Italy. [Estrada-Pena, Agustin] Fac Vet, Dept Parasitol, Zaragoza 50013, Spain. [Levin, Michael] Ctr Dis Control & Prevent, Med Entomol Lab, Rickettsial Zoonoses Branch, DVBD, Atlanta, GA 30333 USA. RP Gray, J (reprint author), Univ Coll Dublin, Sch Biol & Environm Sci, Dublin 4, Ireland. EM jeremy.gray@ucd.ie RI Dantas-Torres, Filipe/G-1617-2012 NR 1 TC 1 Z9 1 U1 1 U2 3 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2015 VL 6 IS 6 BP 872 EP 872 DI 10.1016/j.ttbdis.2015.06.011 PG 1 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA CS5UM UT WOS:000362143800025 ER PT B AU El-Masri, H McLanahan, E Martin, S AF El-Masri, Hisham McLanahan, Eva Martin, Sheppard BE AbouDonia, MB TI Principles of Toxicokinetics and Predictive Toxicokinetics Modeling SO MAMMALIAN TOXICOLOGY LA English DT Article; Book Chapter ID DERMAL ABSORPTION; PHARMACOKINETIC MODEL; PBPK MODEL; PERCUTANEOUS-ABSORPTION; BREATH CONCENTRATIONS; INHALATION EXPOSURE; HUMANS; RATS; CHLOROFORM; OCTAMETHYLCYCLOTETRASILOXANE C1 [El-Masri, Hisham] US EPA, Syst Biol Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Lab,Off Res & Dev, Res Triangle Pk, NC 27711 USA. [McLanahan, Eva] US PHS, Div Community Hlth Invest, Agcy Tox Subst & Dis Registry, Atlanta, GA USA. [Martin, Sheppard] Procter & Gamble Co, Cent Prod Safety, Cincinnati, OH USA. RP El-Masri, H (reprint author), US EPA, Syst Biol Branch, Integrated Syst Toxicol Div, Natl Hlth & Environm Effects Lab,Off Res & Dev, Res Triangle Pk, NC 27711 USA. NR 28 TC 0 Z9 0 U1 0 U2 2 PU BLACKWELL SCIENCE PUBL PI OXFORD PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND BN 978-1-118-68348-4; 978-1-119-94041-8 PY 2015 BP 85 EP 99 PG 15 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA BD5RT UT WOS:000361757100006 ER PT J AU Martin, A Monsour, M Boulet, S Kawwass, J Kissin, D Jamieson, D AF Martin, Angela Monsour, Michael Boulet, Sheree Kawwass, Jennifer Kissin, Dmitry Jamieson, Denise TI Risk of preeclampsia in pregnancies after assisted reproductive technology and ovarian stimulation SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 35th Annual Scientific Pregnancy Meeting of the Society-for-Maternal-Fetal-Medicine (SMFM) CY FEB 02-07, 2015 CL San Diego, CA SP Soc Maternal Fetal Med C1 [Martin, Angela; Kawwass, Jennifer; Jamieson, Denise] Emory Univ, Gynecol & Obstet, Atlanta, GA 30322 USA. [Monsour, Michael; Boulet, Sheree; Kissin, Dmitry] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2015 VL 212 IS 1 SU S MA 765 BP S371 EP S372 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA CR2FG UT WOS:000361140900758 ER PT J AU Fisher, DE Li, CM Hoffman, HJ Chiu, MS Themann, CL Petersen, H Jonsson, PV Jonsson, H Jonasson, F Sverrisdottir, JE Launer, LJ Eiriksdottir, G Gudnason, V Cotch, MF AF Fisher, Diana E. Li, Chuan-Ming Hoffman, Howard J. Chiu, May S. Themann, Christa L. Petersen, Hannes Jonsson, Palmi V. Jonsson, Helgi Jonasson, Fridbert Sverrisdottir, Johanna Eyrun Launer, Lenore J. Eiriksdottir, Gudny Gudnason, Vilmundur Cotch, Mary Frances TI Sex-specific predictors of hearing-aid use in older persons: The age, gene/environment susceptibility - Reykjavik study SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Article DE Age-related hearing loss; hearing impairment; hearing aids; older persons; sex differences ID NUTRITION EXAMINATION SURVEY; QUALITY-OF-LIFE; NATIONAL-HEALTH; HELP-SEEKING; ADULTS; IMPAIRMENT; PREVALENCE; POPULATION; REHABILITATION; MORTALITY AB Objective: We estimate the prevalence of hearing-aid use in Iceland and identify sex-specific factors associated with use. Design : Population-based cohort study. Study sample: A total of 5172 age, gene/environment susceptibility - Reykjavik study (AGES-RS) participants, aged 67 to 96 years (mean age 76.5 years), who completed air-conduction and pure-tone audiometry. Results: Hearing-aid use was reported by 23.0% of men and 15.9% of women in the cohort, although among participants with at least moderate hearing loss in the better ear (pure-tone average [PTA] of thresholds at 0.5, 1, 2, and 4 kHz >= 35 dB hearing level [HL]) it was 49.9% and did not differ by sex. Self-reported hearing loss was the strongest predictor of hearing-aid use in men [OR: 2.68 (95% CI: 1.77, 4.08)] and women [OR: 3.07 (95% CI: 1.94, 4.86)], followed by hearing loss severity based on audiometry. Having diabetes or osteoarthritis were significant positive predictors of use in men, whereas greater physical activity and unimpaired cognitive status were important in women. Conclusions: Hearing-aid use was comparable in Icelandic men and women with moderate or greater hearing loss. Self-recognition of hearing loss was the factor most predictive of hearing-aid use; other influential factors differed for men and women. C1 [Fisher, Diana E.; Cotch, Mary Frances] NEI, Div Epidemiol & Clin Applicat, Intramural Res Program, NIH, Bethesda, MD 20892 USA. [Li, Chuan-Ming; Hoffman, Howard J.; Chiu, May S.] NIDCD, Epidemiol & Stat Program, Div Sci Programs, NIH, Bethesda, MD USA. [Themann, Christa L.] NIOSH, Hearing Loss Prevent Team, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Petersen, Hannes; Jonsson, Palmi V.; Jonsson, Helgi; Jonasson, Fridbert; Gudnason, Vilmundur] Univ Iceland, Fac Med, Reykjavik, Iceland. [Petersen, Hannes] Landspitali Univ Hosp, Dept Otolaryngol Head & Neck Surg, Reykjavik, Iceland. [Jonsson, Palmi V.] Landspitali Univ Hosp, Dept Geriatr, Reykjavik, Iceland. [Jonsson, Helgi] Landspitali Univ Hosp, Dept Rheumatol, Reykjavik, Iceland. [Jonasson, Fridbert] Landspitali Univ Hosp, Dept Ophthalmol, Reykjavik, Iceland. [Sverrisdottir, Johanna Eyrun; Eiriksdottir, Gudny; Gudnason, Vilmundur] Iceland Heart Assoc, Kopavogur, Iceland. [Launer, Lenore J.] NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH, Bethesda, MD 20892 USA. RP Fisher, DE (reprint author), NEI, Div Epidemiol & Clin Applicat, NIH, Bldg 10 CRC,Room 3-2521, Bethesda, MD 20892 USA. EM diana.fisher@nih.gov RI Gudnason, Vilmundur/K-6885-2015; OI Gudnason, Vilmundur/0000-0001-5696-0084; Cotch, Mary Frances/0000-0002-2046-4350 FU Intramural Research Programs of the National Institute of Aging [ZIAAG007380]; National Eye Institute [ZIAEY000401]; National Institute on Deafness and Other Communication Disorders [IAA Y2-DC-1004-02]; National Institutes of Health, Bethesda, Maryland, USA [N01-AG-12100]; Icelandic Heart Association, Kopavogur, Iceland; Icelandic Parliament, Reykjavik, Iceland; University of Iceland Research Fund, Reykjavik, Iceland; Helga Jonsdottir and Sigurlidi Kristjansson Research Fund, Reykjavik, Iceland FX The authors thank the AGES-RS participants; without whom the study would not be possible. Sources of funding: This work was supported by the Intramural Research Programs of the National Institute of Aging ZIAAG007380) and the National Eye Institute (ZIAEY000401), and the National Institute on Deafness and Other Communication Disorders (IAA Y2-DC-1004-02), National Institutes of Health (N01-AG-12100), Bethesda, Maryland, USA; the Icelandic Heart Association, Kopavogur, Iceland; the Icelandic Parliament, Reykjavik, Iceland; the University of Iceland Research Fund, Reykjavik, Iceland; and the Helga Jonsdottir and Sigurlidi Kristjansson Research Fund, Reykjavik, Iceland. The sponsors had no role in the design, methods, subject recruitment, data collection, data analysis, or preparation of the paper. NR 33 TC 1 Z9 1 U1 1 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1499-2027 EI 1708-8186 J9 INT J AUDIOL JI Int. J. Audiol. PY 2015 VL 54 IS 9 BP 634 EP 641 DI 10.3109/14992027.2015.1024889 PG 8 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA CR4UE UT WOS:000361334200009 PM 25816699 ER PT J AU Dong, J Ma, Q AF Dong, Jie Ma, Qiang TI Advances in mechanisms and signaling pathways of carbon nanotube toxicity SO NANOTOXICOLOGY LA English DT Review DE Carbon nanotubes; fiber toxicity; mechanism; signaling pathway; nanotoxicology ID NLRP3 INFLAMMASOME ACTIVATION; EPITHELIAL-MESENCHYMAL TRANSITION; NF-KAPPA-B; HUMAN MESOTHELIAL CELLS; MALE FISCHER-344 RATS; IN-VITRO TOXICITY; OXIDATIVE STRESS; PULMONARY-FIBROSIS; NALP3 INFLAMMASOME; TGF-BETA AB Carbon nanotubes (CNT) have been developed into new materials with a variety of industrial and commercial applications. In contrast, the physicochemical properties of CNT at the nanoscale render them the potency to generate toxic effects. Indeed, the potential health impacts of CNT have drawn a great deal of attention in recent years, owing to their identified toxicological and pathological consequences including cytotoxicity, inflammation, fibrosis, genotoxicity, tumorigenesis, and immunotoxicity. Understanding the mechanisms by which CNT induce toxicity and pathology is thus urgently needed for accurate risk assessment of CNT exposure in humans, and for safe and responsible development and commercialization of nanotechnology. Here, we summarize and discuss recent advances in this area with a focus on the molecular interactions between CNT and mammalian systems, and the signaling pathways important for the development of CNT toxicity such as the NE-KB, NLRP3 inflammasome, TGF-beta 1, MAPK, and p53 signaling cascades. With the current mechanistic evidence summarized in this review, we expect to provide new insights into CNT toxicology at the molecular level and offer new clues to the prevention of health effects resulting from CNT exposure. Moreover, we disclose questions and issues that remain in this rapidly advancing field of nanotoxicology, which would facilitate ascertaining future research directions. C1 [Dong, Jie; Ma, Qiang] NIOSH, Receptor Biol Lab, Toxicol & Mol Biol Branch, Hlth Effects Lab Div,Ctr Dis Control & Prevent, Morgantown, WV USA. RP Ma, Q (reprint author), CDC NIOSH HELD TMBB, Mailstop 3014,1095 Willowdale Rd, Morgantown, WV 26505 USA. EM qam1@cdc.gov FU National Institute for Occupational Safety and Health, Health Effects Laboratory Division FX The authors declare that they have no competing interests. The study was funded to QM by National Institute for Occupational Safety and Health, Health Effects Laboratory Division. NR 162 TC 16 Z9 18 U1 4 U2 30 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1743-5390 EI 1743-5404 J9 NANOTOXICOLOGY JI Nanotoxicology PY 2015 VL 9 IS 5 BP 658 EP 676 DI 10.3109/17435390.2015.1009187 PG 19 WC Nanoscience & Nanotechnology; Toxicology SC Science & Technology - Other Topics; Toxicology GA CR4SW UT WOS:000361329800011 PM 25676622 ER PT S AU Freire, KE Perkinson, L Morrel-Samuels, S Zimmerman, MA AF Freire, Kimberley E. Perkinson, Leah Morrel-Samuels, Susan Zimmerman, Marc A. BE McCoy, KP Diana, A TI Three Cs of Translating Evidence-Based Programs for Youth and Families to Practice Settings SO SCIENCE, AND ART, OF PROGRAM DISSEMINATION: STRATEGIES, SUCCESSES, AND CHALLENGES SE New Directions for Child and Adolescent Development LA English DT Article; Book Chapter ID INTERACTIVE SYSTEMS FRAMEWORK; VIOLENCE PREVENTION PROGRAM; RANDOMIZED CONTROLLED-TRIAL; BEHAVIORAL INTERVENTIONS; PUBLIC-HEALTH; IMPLEMENTATION; FIDELITY; DISSEMINATION; ADAPTATION; PROVIDERS AB Despite the growing number of evidence-based programs (EBPs) for youth and families, few are well-integrated in service systems or widely adopted by communities. One set of challenges to widespread adoption of EBPs relates to the transfer of programs from research and development to practice settings. This is often because program developers have limited guidance on how to prepare their programs for broad dissemination in practice settings. We describe Three Cs of Translation, which are key areas that are essential for developers to translate their EBPs from research to practice settings: (1) Communicate the underlying theory in terms easily understandable to end users, (2) Clarifyfidelity and flexibility, and (3) Codify implementation lessons and examples. Program developers are in the best position to describe their interventions, to define intervention core components, to clarify fidelity and flexibility, and to codify implementation lessons from intervention studies. We note several advantages for developers to apply the Three Cs prior to intervention dissemination and provide specific recommendations for translation. (C) 2015 Wiley Periodicals, Inc. C1 [Freire, Kimberley E.] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA 30333 USA. [Perkinson, Leah] Ctr Dis Control & Prevent, Div Violence Prevent, CDC Fdn, Atlanta, GA USA. [Morrel-Samuels, Susan] Univ Michigan, Prevent Res Ctr Michigan, Ann Arbor, MI 48109 USA. [Morrel-Samuels, Susan] Univ Michigan, Michigan Youth Violence Prevent Ctr, Ann Arbor, MI 48109 USA. [Zimmerman, Marc A.] Univ Michigan, Sch Publ Hlth, Dept Hlth Behav & Hlth Educ, Ann Arbor, MI 48109 USA. RP Freire, KE (reprint author), Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA 30333 USA. NR 55 TC 1 Z9 1 U1 7 U2 9 PU WILEY PERIODICALS PI SAN FRANCISCO PA 989 MARKET STREET, SAN FRANCISCO, CA 94103-1741 USA SN 1534-8687 J9 NEW DIR CHILD ADOLES PY 2015 VL 149 BP 25 EP 39 DI 10.1002/cad.20111 PG 15 WC Psychology, Developmental; Social Work SC Psychology; Social Work GA BD5DO UT WOS:000361332500003 ER PT J AU Lopez, LM Chen, M Long, SM Curtis, KM Helmerhorst, FM AF Lopez, Laureen M. Chen, Mario Long, Sarah Mullins Curtis, Kathryn M. Helmerhorst, Frans M. TI Steroidal contraceptives and bone fractures in women: evidence from observational studies SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review DE Age Factors; Case-Control Studies; Cohort Studies; Contraceptives; Oral, Hormonal [adverse effects]; Fractures, Bone [chemically induced]; Intrauterine Devices, Medicated [adverse effects]; Medroxyprogesterone Acetate [adverse effects]; Progestins [adverse effects]; Time Factors; Female; Humans ID DEPOT MEDROXYPROGESTERONE ACETATE; RANDOMIZED CONTROLLED-TRIAL; MINERAL DENSITY; RISK-FACTORS; ORAL-CONTRACEPTION; HORMONAL CONTRACEPTION; PERIMENOPAUSAL WOMEN; DISTAL FOREARM; HIP FRACTURE; VITAMIN-D AB Background Age-related decline in bone mass increases the risk of skeletal fractures, especially those of the hip, spine, and wrist. Steroidal contraceptives have been associated with changes in bone mineral density in women. Whether such changes affect the risk of fractures later in life is unclear. Hormonal contraceptives are among the most effective and most widely-used contraceptives. Concern about fractures may limit the use of these effective contraceptives. Observational studies can collect data on premenopausal contraceptive use as well as fracture incidence later in life. Objectives We systematically reviewed the evidence from observational studies of hormonal contraceptive use for contraception and the risk of fracture in women. Search methods Through June 2015, we searched for observational studies. The databases included PubMed, POPLINE, Cochrane Central Register of Controlled Trials (CENTRAL), LILACS, EMBASE, CINAHL, and Web of Science. We also searched for recent clinical trials through ClinicalTrials.gov and the ICTRP. For other studies, we examined reference lists of relevant articles and wrote to investigators for additional reports. Selection criteria We included cohort and case-control studies of hormonal contraceptive use. Interventions included comparisons of a hormonal contraceptive with a non-hormonal contraceptive, no contraceptive, or another hormonal contraceptive. The primary outcome was the risk of fracture. Data collection and analysis Two authors independently extracted the data. One author entered the data into RevMan, and a second author verified accuracy. We examined the quality of evidence using the Newcastle-Ottawa Quality Assessment Scale (NOS), developed for case-control and cohort studies. Sensitivity analysis included studies of moderate or high quality based on our assessment with the NOS. Given the need to control for confounding factors in observational studies, we used adjusted estimates from the models as reported by the authors. Where we did not have adjusted analyses, we calculated the odds ratio (OR) with 95% confidence interval (CI). Due to varied study designs, we did not conduct meta-analysis. Main results We included 14 studies (7 case-control and 7 cohort studies). These examined oral contraceptives (OCs), depot medroxyprogesterone acetate (DMPA), and the hormonal intrauterine device (IUD). This section focuses on the sensitivity analysis with six studies that provided moderate or high quality evidence. All six studies examined oral contraceptive use. We noted few associations with fracture risk. One cohort study reported OC ever-users had increased risk for all fractures (RR 1.20, 95% CI 1.08 to 1.34). However, a case-control study with later data from a subset reported no association except for those with 10 years or more since use (OR 1.55, 95% CI 1.03 to 2.33). Another case-control study reported increased risk only for those who had 10 or more prescriptions (OR 1.09, 95% CI 1.03 to 1.16). A cohort study of postmenopausal women found no increased fracture risk for OC use after excluding women with prior fracture. Two other studies found little evidence of association between OC use and fracture risk. A cohort study noted increased risk for subgroups, such as those with longer use or specific intervals since use. A case-control study reported increased risk for any fracture only among young women with less than average use. Two case-control studies also examined progestin-only contraceptives. One reported increased fracture risk for DMPA ever-use (OR 1.44, 95% CI 1.01 to 2.06), more than four years of use (OR 2.16, 95% CI 1.32 to 3.53), and women over 50 years old. The other reported increased risk for any past use, including one or two prescriptions (OR 1.17, 95% CI 1.07 to 1.29) and for current use of 3 to 9 prescriptions (OR 1.36, 95% CI 1.15 to 1.60) or 10 or more (OR 1.54, 95% CI 1.33 to 1.78). For the levonorgestrel-releasing IUD, one study reported reduced fracture risk for ever-use (OR 0.75, 95% CI 0.64 to 0.87) and for longer use. Authors' conclusions Observational studies do not indicate an overall association between oral contraceptive use and fracture risk. Some reported increased risk for specific user subgroups. DMPA users may have an increased fracture risk. One study indicated hormonal IUD use may be associated with decreased risk. Observational studies need adjusted analysis because the comparison groups usually differ. Investigators should be clear about the variables examined in multivariate analysis. C1 [Lopez, Laureen M.; Long, Sarah Mullins] Clin & Epidemiol Sci, Durham, NC 27701 USA. [Curtis, Kathryn M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Helmerhorst, Frans M.] Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands. RP Lopez, LM (reprint author), Clin & Epidemiol Sci, FHI 360,359 Blackwell St,Suite 200, Durham, NC 27701 USA. EM llopez@fhi360.org FU National Institute of Child Health and Human Development, USA; United States Agency for International Development, USA FX External sources; National Institute of Child Health and Human Development, USA.; Funding to FHI 360 for conducting the review (LML, SM, MC); United States Agency for International Development, USA.; Funding to FHI 360 for conducting the review (LML, SM, MC) NR 62 TC 1 Z9 1 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X EI 1361-6137 J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2015 IS 7 AR CD009849 DI 10.1002/14651858.CD009849.pub3 PG 71 WC Medicine, General & Internal SC General & Internal Medicine GA CQ5MF UT WOS:000360647800047 PM 26195091 ER PT J AU Blanton, E Wilhelm, N O'Reilly, C Muhonja, E Karoki, S Ope, M Langat, D Omolo, J Wamola, N Oundo, J Hoekstra, R Ayers, T De Cock, K Breiman, R Mintz, E Lantagne, D AF Blanton, Elizabeth Wilhelm, Natalie O'Reilly, Ciara Muhonja, Everline Karoki, Solomon Ope, Maurice Langat, Daniel Omolo, Jared Wamola, Newton Oundo, Joseph Hoekstra, Robert Ayers, Tracy De Cock, Kevin Breiman, Robert Mintz, Eric Lantagne, Daniele TI A rapid assessment of drinking water quality in informal settlements after a cholera outbreak in Nairobi, Kenya SO JOURNAL OF WATER AND HEALTH LA English DT Article DE cholera; E. coli; informal settlements; water quality; water treatment ID URBAN; TRANSMISSION; EPIDEMIC AB Populations living in informal settlements with inadequate water and sanitation infrastructure are at risk of epidemic disease. In 2010, we conducted 398 household surveys in two informal settlements in Nairobi, Kenya with isolated cholera cases. We tested source and household water for free chlorine residual (FCR) and Escherichia coli in approximately 200 households. International guidelines are >= 0.5 mg/L FCR at source, >= 0.2 mg/L at household, and <1 E. coli/100 mL. In these two settlements, 82% and 38% of water sources met FCR guidelines; and 7% and 8% were contaminated with E. coli, respectively. In household stored water, 82% and 35% met FCR guidelines and 11% and 32% were contaminated with E. coli, respectively. Source water FCR >= 0.5 mg/L (p = 0.003) and reported purchase of a household water treatment product (p = 0.002) were associated with increases in likelihood that household stored water had >= 0.2 mg/L FCR, which was associated with a lower likelihood of E. coli contamination (p < 0.001). These results challenge the assumption that water quality in informal settlements is universally poor and the route of disease transmission, and highlight that providing centralized water with >= 0.5 mg/L FCR or (if not feasible) household water treatment technologies reduces the risk of waterborne cholera transmission in informal settlements. C1 [Blanton, Elizabeth; O'Reilly, Ciara; Hoekstra, Robert; Ayers, Tracy; Mintz, Eric; Lantagne, Daniele] US Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. [Wilhelm, Natalie; Lantagne, Daniele] Tufts Univ, Boston, MA 02111 USA. [Muhonja, Everline; Karoki, Solomon; Omolo, Jared] Field Epidemiol & Lab Training Program, Nairobi, Kenya. [Muhonja, Everline; Karoki, Solomon; Ope, Maurice; Langat, Daniel; Omolo, Jared] Minist Publ Hlth & Sanitat, Nairobi, Kenya. [Wamola, Newton; Oundo, Joseph] Kenya Govt Med Res Ctr, Nairobi, Kenya. [De Cock, Kevin; Breiman, Robert] US Ctr Dis Control & Prevent, Ctr Global Hlth, Nairobi, Kenya. [Breiman, Robert] Emory Univ, Emory Global Hlth Inst, Atlanta, GA 30322 USA. [Breiman, Robert] US Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA USA. RP Wilhelm, N (reprint author), Tufts Univ, Boston, MA 02111 USA. EM Natalie.Wilhelm@tufts.edu OI Ayers, Tracy/0000-0003-4140-3263 NR 30 TC 0 Z9 0 U1 6 U2 11 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1477-8920 J9 J WATER HEALTH JI J. Water Health PY 2015 VL 13 IS 3 BP 714 EP 725 DI 10.2166/wh.2014.173 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health; Microbiology; Water Resources SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Microbiology; Water Resources GA CQ7OI UT WOS:000360793100009 PM 26322757 ER PT J AU Hutson, CL Carroll, DS Gallardo-Romero, N Drew, C Zaki, SR Nagy, T Hughes, C Olson, VA Sanders, J Patel, N Smith, SK Keckler, MS Karem, K Damon, IK AF Hutson, Christina L. Carroll, Darin S. Gallardo-Romero, Nadia Drew, Clifton Zaki, Sherif R. Nagy, Tamas Hughes, Christine Olson, Victoria A. Sanders, Jeanine Patel, Nishi Smith, Scott K. Keckler, M. Shannon Karem, Kevin Damon, Inger K. TI Comparison of Monkeypox Virus Clade Kinetics and Pathology within the Prairie Dog Animal Model Using a Serial Sacrifice Study Design SO BIOMED RESEARCH INTERNATIONAL LA English DT Article ID NEOSPORA-CANINUM; WILD RODENTS; CONGO BASIN; DEATH; TRANSMISSION; INFECTION; APOPTOSIS; OUTBREAK; MAMMALS AB Monkeypox virus (MPXV) infection of the prairie dog is valuable to studying systemic orthopoxvirus disease. To further characterize differences in MPXV clade pathogenesis, groups of prairie dogs were intranasally infected (8x10(3) p.f.u.) with Congo Basin (CB) or West African (WA) MPXV, and 28 tissues were harvested on days 2, 4, 6, 9, 12, 17, and 24 postinfection. Samples were evaluated for the presence of virus and gross and microscopic lesions. Virus was recovered from nasal mucosa, oropharyngeal lymph nodes, and spleen earlier in CB challenged animals (day 4) than WA challenged animals (day 6). For both groups, primary viremia (indicated by viral DNA) was seen on days 6-9 through day 17. CB MPXV spread more rapidly, accumulated to greater levels, and caused greater morbidity in animals compared to WA MPXV. Histopathology and immunohistochemistry (IHC) findings, however, were similar. Two animals that succumbed to disease demonstrated abundant viral antigen in all organs tested, except for brain. Dual IHC staining of select liver and spleen sections showed that apoptotic cells (identified by TUNEL) tended to colocalize with poxvirus antigen. Interestingly splenocytes were labelled positive for apoptosis more often than hepatocytes in both MPXV groups. These findings allow for further characterization of differences between MPXV clade pathogenesis, including identifying sites that are important during early viral replication and cellular response to viral infection. C1 [Hutson, Christina L.; Carroll, Darin S.; Gallardo-Romero, Nadia; Drew, Clifton; Zaki, Sherif R.; Hughes, Christine; Olson, Victoria A.; Sanders, Jeanine; Patel, Nishi; Smith, Scott K.; Keckler, M. Shannon; Karem, Kevin; Damon, Inger K.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Atlanta, GA 30333 USA. [Hutson, Christina L.; Nagy, Tamas] Univ Georgia, Dept Pathol, Coll Vet Med, Athens, GA 30602 USA. RP Hutson, CL (reprint author), Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Atlanta, GA 30333 USA. EM zuu6@cdc.gov NR 33 TC 0 Z9 0 U1 0 U2 0 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 2314-6133 EI 2314-6141 J9 BIOMED RES INT JI Biomed Res. Int. PY 2015 AR 965710 DI 10.1155/2015/965710 PG 19 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA CQ7AG UT WOS:000360754600001 ER PT J AU Tiesman, HM Heick, RJ Konda, S Hendricks, S AF Tiesman, Hope M. Heick, Rebecca J. Konda, Srinivas Hendricks, Scott TI Law enforcement officers' risk perceptions toward on-duty motor-vehicle events SO POLICING-AN INTERNATIONAL JOURNAL OF POLICE STRATEGIES & MANAGEMENT LA English DT Article DE Risk perception; Law enforcement; Motor-vehicle crash; Occupational injury ID FATAL OCCUPATIONAL INJURIES; QUALITY-OF-LIFE; POLICE OFFICERS; SAFETY BEHAVIOR; STRESS; HEALTH; WORK; CLIMATE AB Purpose - Motor-vehicle-related events (MVEs) are the leading cause of on-duty death for law enforcement officers, yet little is known about how officers view this significant job hazard. The purpose of this paper is to explore officers' motor-vehicle risk perception and examine how prior on-duty MVEs and the death or injury of a fellow officer influences this perception. Design/methodology/approach - A state-wide random sample of 136 law enforcement agencies was drawn using publically accessible databases, stratified on type and size of agency. In total, 60 agencies agreed to participate and a cross-sectional questionnaire was distributed to 1,466 officers. Using six-point Likert scales, composite scores for motor-vehicle and intentional violence risk perception were derived. A linear regression multivariable model was used to examine factors affecting motor-vehicle risk perception. Findings - Motor-vehicle risk perception scores were significantly higher than intentional violence scores. A prior on-duty motor-vehicle crash, prior roadside incident, or knowledge of fellow officer's injury or death from a MVE significantly increased motor-vehicle risk perception scores. After controlling for potential confounders though, only prior on-duty crashes and roadside incidents impacted motor-vehicle risk perception. Research limitations/implications - The study comprised primarily small, rural agencies and generalizability may be limited. Also, although the data were collected anonymously, reporting and response biases may affect these findings. Originality/value - This study involved a large and diverse cohort of officers and explored motor-vehicle risk perception. A better understanding of officers' risk perceptions will assist in the development and implementation of occupational injury prevention programs, training, and policy. C1 [Tiesman, Hope M.; Konda, Srinivas; Hendricks, Scott] NIOSH, Div Safety Res, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Heick, Rebecca J.] MCPHS Univ, MCPHS Online, Boston, MA USA. RP Tiesman, HM (reprint author), NIOSH, Div Safety Res, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. EM htiesman@cdc.gov FU National Institute for Occupational Safety and Health FX This project was funded by the National Institute for Occupational Safety and Health. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. NR 53 TC 0 Z9 0 U1 0 U2 0 PU EMERALD GROUP PUBLISHING LIMITED PI BINGLEY PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND SN 1363-951X EI 1758-695X J9 POLICING JI Policing-An Int J Police Strategies & Manag. PY 2015 VL 38 IS 3 SI SI BP 563 EP 577 DI 10.1108/PIJPSM-03-2015-0028 PG 15 WC Criminology & Penology SC Criminology & Penology GA CP7NG UT WOS:000360074300009 PM 26380563 ER PT J AU Schuchat, A AF Schuchat, Anne TI Measles in our time: the US experience SO FUTURE VIROLOGY LA English DT Editorial Material DE measles; measles vaccine; outbreak; philosphical exemptions ID SCHOOL IMMUNIZATION REQUIREMENTS; UNITED-STATES; NONMEDICAL EXEMPTIONS; VACCINATION COVERAGE; OUTBREAK; PERTUSSIS; ELIMINATION; CHILDREN C1 Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Schuchat, A (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM aschuchat@cdc.gov NR 21 TC 0 Z9 0 U1 2 U2 5 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 1746-0794 EI 1746-0808 J9 FUTURE VIROL JI Future Virol. PY 2015 VL 10 IS 7 BP 809 EP 812 DI 10.2217/FVL.15.54 PG 4 WC Virology SC Virology GA CO6KR UT WOS:000359266100001 ER PT J AU Yu, SF Lu, ML Gu, GZ Zhou, WH He, LH Wang, S AF Yu, Shanfa Lu, Ming-Lun Gu, Guizhen Zhou, Wenhui He, Lihua Wang, Sheng TI Association between psychosocial job characteristics and sickness absence due to low back symptoms using combined DCS and ERI models SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Article DE Demand-control-support; efforts-reward-overcommittment; stress; low back symptoms; sickness absence ID EFFORT-REWARD IMBALANCE; MUSCULOSKELETAL SYMPTOMS; RISK-FACTORS; PROSPECTIVE COHORT; WORK CHARACTERISTICS; SOCIAL SUPPORT; STRESS MODELS; STRAIN; PAIN; HEALTH AB OBJECTIVE: To evaluate the combined demand-control-support (DCS) and effort-reward-overcommitment (ERI-OC) stress models in association with sickness absence due to low back symptoms (SA-LBS). METHODS: A total of 2,737 blue-collar workers recruited from 13 companies in the most populous province (Henan) of China were included in the study. Personal and physical job characteristics, psychosocial scales of the stress models, and SA-LBS data in the preceding year were collected by a self-reported questionnaire and analyzed by a multivariable logistic regression model. Tertile exposure levels (low, medium and high) were constructed to discriminate a risk level. Odds ratios (OR) with 95% confidence intervals (CI) were used as the association with SA-LBS. RESULTS: A large percentage (84.5%) of the Chinese workers did not take sick leave after reporting low back symptoms during the preceding year. High job demand or medium high reward was associated with SA-LBS. The association of the combined stress models and SA-LBS was not evident. CONCLUSIONS: The ERI-OC model appeared to be more predictive of SA-LBS than the DCS model in the study population. The advantage of using combined stress models for predicting SA-LBS is not evident. C1 [Yu, Shanfa; Gu, Guizhen; Zhou, Wenhui] Henan Prov Inst Occupat Hlth, Zhengzhou, Henan, Peoples R China. [Lu, Ming-Lun] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [He, Lihua; Wang, Sheng] Peking Univ, Hlth Sci Ctr, Beijing 100871, Peoples R China. RP Lu, ML (reprint author), NIOSH, 4676 Columbia Pkwy,MS C-24, Cincinnati, OH 45226 USA. EM mlu@cdc.gov FU Intramural CDC HHS [CC999999] NR 53 TC 2 Z9 2 U1 1 U2 5 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 EI 1875-9270 J9 WORK JI Work PY 2015 VL 51 IS 3 SI SI BP 411 EP 421 DI 10.3233/WOR-141881 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CP3BF UT WOS:000359751100004 PM 24939110 ER PT S AU Maalouf, J Cogswell, ME Yuan, KM Martin, C Gillespie, C Ahuja, JKC Pehrsson, P Merritt, R AF Maalouf, Joyce Cogswell, Mary E. Yuan, Keming Martin, Carrie Gillespie, Cathleen Ahuja, Jaspreet K. C. Pehrsson, Pamela Merritt, Robert BE Mitchell, DC Braithwaite, E TI Sodium Content of Foods Contributing to Sodium Intake: Comparison between Selected Foods from the CDC Packaged Food Database and the USDA National Nutrient Database for Standard Reference SO 38TH NATIONAL NUTRIENT DATABANK CONFERENCE SE Procedia Food Science LA English DT Proceedings Paper CT 38th National Nutrient Databank Conference (NNDC) CY MAY, 2014 CL Oregon Hlth Sci Univ, Portland, OR HO Oregon Hlth Sci Univ DE sodium; Sentinel Foods; database; laboratory analysis ID PROCESSED FOODS; RESTAURANT FOODS; UNITED-STATES; NEW-ZEALAND; DISEASE; POLICY AB The sodium concentration (mg/100g) for 23 of 125 Sentinel Foods (e.g. white bread) were identified in the 2009 CDC Packaged Food Database (PFD) and compared with data in the USDA's 2013 National Nutrient Database for Standard Reference(SR 26). Sentinel Foods are foods identified by USDA to be monitored as primary indicators to assess the changes in the sodium content of commercially processed foods from stores and restaurants. Overall, 937 products were evaluated in the CDC PFD, and between 3 (one brand of ready-to-eat cereal) and 126 products (white bread) were evaluated per selected food. The mean sodium concentrations of 17 of the 23 (74%) selected foods in the CDC PFD were 90%-110% of the mean sodium concentrations in SR 26 and differences in sodium concentration were statistically significant for 6 Sentinel Foods. The sodium concentration of most of the Sentinel Foods, as selected in the PFD, appeared to represent the sodium concentrations of the corresponding food category. The results of our study help improve the understanding of how nutrition information compares between national analytic values and the label and whether the selected Sentinel Foods represent their corresponding food category as indicators for assessment of change of the sodium content in the food supply. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under CC BY-NC-ND license (1ittp://creativecommonsAwgdicensesr1y-ncmd/4.0/) Peer-review under responsibility of the National Nutrient Databank Steering Committee C1 [Maalouf, Joyce; Cogswell, Mary E.; Yuan, Keming; Gillespie, Cathleen; Merritt, Robert] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. [Maalouf, Joyce] IHRC Inc, Atlanta, GA 30346 USA. [Martin, Carrie; Ahuja, Jaspreet K. C.; Pehrsson, Pamela] ARS, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD 20705 USA. RP Maalouf, J (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. EM vjh6@cdc.gov FU Intramural CDC HHS [CC999999] NR 25 TC 1 Z9 1 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 2211-601X J9 PROC FOOD SCI PY 2015 VL 4 BP 114 EP 124 DI 10.1016/j.profoo.2015.06.016 PG 11 WC Food Science & Technology; Nutrition & Dietetics SC Food Science & Technology; Nutrition & Dietetics GA BD2HB UT WOS:000358738000015 PM 26484010 ER PT J AU Vickerman, KA Schauer, GL Malarcher, AM Zhang, L Mowery, P Nash, CM AF Vickerman, Katrina A. Schauer, Gillian L. Malarcher, Ann M. Zhang, Lei Mowery, Paul Nash, Chelsea M. TI Quitline Use and Outcomes among Callers with and without Mental Health Conditions: A 7-Month Follow-Up Evaluation in Three States SO BIOMED RESEARCH INTERNATIONAL LA English DT Article ID SMOKING-CESSATION; COST-EFFECTIVENESS; CIGARETTE-SMOKING; BIPOLAR DISORDER; MAJOR DEPRESSION; NICOTINE PATCH; INTERVENTIONS; SMOKERS; ILLNESSES; TRIAL AB Objectives. To examine abstinence outcomes among tobacco users with and without a reported mental health condition (MHC) who enrolled in state tobacco quitline programs. Methods. Data were analyzed from a 7-month follow-up survey (response rate: 41% [3,132/7,459]) of three state-funded telephone quitline programs in the United States that assessed seven self-reported MHCs at quitline registration. We examined 30-day point prevalence tobacco quit rates for callers with any MHC versus none. Data were weighted to adjust for response bias and oversampling. Multivariable logistic regression was used to examine cessation outcomes. Results. Overall, 45.8% of respondents reported >= 1 MHC; 57.4% of those reporting a MHC reported >= 2 MHCs. The unadjusted quit rate for callers with any MHC was lower than for callers with no MHC (22.0% versus 31.0%, p < 0.001). After adjusting for demographics, nicotine dependence, and program engagement, callers reporting >= 1 MHC were less likely to be abstinent at followup (adjusted OR = 0.63, 95% CI = 0.51-0.78, p < 0.001). Conclusions. More intensive or tailored quitline programs may need to be developed among callers with MHCs as their quit rates appear to be lower than callers without MHCs. C1 [Vickerman, Katrina A.; Nash, Chelsea M.] Alere Wellbeing Inc, Seattle, WA 98104 USA. [Schauer, Gillian L.] Carter Consulting Inc, Off Smoking & Hlth, Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Malarcher, Ann M.; Zhang, Lei] Off Smoking & Hlth, Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Mowery, Paul] Biostat Inc, Sarasota, FL 34239 USA. RP Vickerman, KA (reprint author), Alere Wellbeing Inc, 999 Third Ave,Suite 2000, Seattle, WA 98104 USA. EM katrina.vickerman@alere.com FU Centers for Disease Control and Prevention; Maryland state quitline; Nebraska state quitline; North Carolina state quitline FX This research was funded by the Centers for Disease Control and Prevention. The Maryland, Nebraska, and North Carolina state quitlines funded the collection of the 7-month survey data analyzed in this study as part of their quitline program evaluation plan. The authors thank Drs. Tim McAfee and Susan Zbikowski for their review and feedback on this paper and for input on the study design. The authors also acknowledge the three state quitlines that participated in the study. NR 50 TC 3 Z9 3 U1 2 U2 6 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 2314-6133 EI 2314-6141 J9 BIOMED RES INT JI Biomed Res. Int. PY 2015 AR 817298 DI 10.1155/2015/817298 PG 11 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA CO6AL UT WOS:000359239500001 ER PT J AU Monaghan, AJ Moore, SM Sampson, KM Beard, CB Eisen, RJ AF Monaghan, Andrew J. Moore, Sean M. Sampson, Kevin M. Beard, Charles B. Eisen, Rebecca J. TI Climate change influences on the annual onset of Lyme disease in the United States SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE Lyme disease; Climate change; Ixodes scapularis; Borrelia burgdorferi ID VECTOR IXODES-SCAPULARIS; BORRELIA-BURGDORFERI; SATURATION DEFICIT; QUESTING ACTIVITY; SEASONAL ACTIVITY; TICK; RICINUS; ACARI; RISK; PATTERNS AB Lyme disease is the most commonly reported vector-borne illness in the United States. Lyme disease occurrence is highly seasonal and the annual springtime onset of cases is modulated by meteorological conditions in preceding months. A meteorological-based empirical model for Lyme disease onset week in the United States is driven with downscaled simulations from five global climate models and four greenhouse gas emissions scenarios to project the impacts of 21st century climate change on the annual onset week of Lyme disease. Projections are made individually and collectively for the 12 eastern States where >90% of cases occur. The national average annual onset week of Lyme disease is projected to become 0.4-0.5 weeks earlier for 2025-2040 (p < 0.05), and 0.7-1.9 weeks earlier for 2065-2080 (p < 0.01), with the largest shifts for scenarios with the highest greenhouse gas emissions. The more southerly mid-Atlantic States exhibit larger shifts (1.0-3.5 weeks) compared to the Northeastern and upper Midwestern States (0.2-2.3 weeks) by 2065-2080. Winter and spring temperature increases primarily cause the earlier onset. Greater spring precipitation and changes in humidity partially counteract the temperature effects. The model does not account for the possibility that abrupt shifts in the life cycle of Ixodes scapularis, the primary vector of the Lyme disease spirochete Borrelia burgdorferi in the eastern United States, may alter the disease transmission cycle in unforeseen ways. The results suggest 21st century climate change will make environmental conditions suitable for earlier annual onset of Lyme disease cases in the United States with possible implications for the timing of public health interventions. (C) 2015 Elsevier GmbH. All rights reserved. C1 [Monaghan, Andrew J.; Sampson, Kevin M.] Natl Ctr Atmospher Res, Res Applicat Lab, Boulder, CO 80301 USA. [Moore, Sean M.] Johns Hopkins Sch Publ Hlth, Baltimore, MD 21205 USA. [Beard, Charles B.; Eisen, Rebecca J.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80522 USA. RP Monaghan, AJ (reprint author), Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA. EM monaghan@ucar.edu; semoore@jhsph.edu; ksampson@ucar.edu; cbb0@cdc.gov; dyn2@cdc.gov OI Sampson, Kevin/0000-0002-5537-7775; Monaghan, Andrew/0000-0002-8170-2359 FU Centers for Disease Control and Prevention; National Science Foundation FX We acknowledge the World Climate Research Programme's Working Group on Coupled Modelling, which is responsible for The Coupled Model Intercomparison Experiment, and we thank the climate modeling groups (listed in Table 1 of this paper) for producing and making their model output available. The U.S. Department of Energy's Program for Climate Model Diagnosis and Intercomparison provides coordinating support and led the development of software infrastructure in partnership with the Global Organization for Earth System Science Portals. The Centers for Disease Control and Prevention funded this work. The National Science Foundation supports the National Center for Atmospheric Research. NR 56 TC 5 Z9 5 U1 11 U2 35 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2015 VL 6 IS 5 BP 615 EP 622 DI 10.1016/j.ttbdis.2015.05.005 PG 8 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA CO3AJ UT WOS:000359028300012 PM 26025268 ER PT J AU Farber, FR Muehlenbachs, A Robey, TE AF Farber, F. R. Muehlenbachs, A. Robey, T. E. TI Atraumatic splenic rupture from Babesia: A disease of the otherwise healthy patient SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE Babesia; Splenic rupture; Case report; Parasitemia ID MICROTI INFECTION; MALARIA; COMPLICATIONS AB Babesiosis, an infection caused by the protozoan Babesia microti and transmitted by the Ixodes scapularis tick, is commonly described in the literature with an approximate incidence of 1000 cases per year (Herwaldt et al., 2012). Infections in North America occur most frequently during the spring and summer months in the Northeastern and Midwestern United States. Babesia can cause a wide spectrum of clinical manifestations ranging from a self-limited febrile illness or mild anemia to severe illness causing acute respiratory distress syndrome (ARDS), disseminated intravascular coagulopathy (DIC) and multisystem organ failure. Severe illness most commonly occurs in elderly, immunocompromised, or asplenic patients (Vannier and Krause, 2012). Splenic rupture has been generally described as a complication of severe illness secondary to babesiosis. We describe a case of spontaneous splenic rupture in an otherwise healthy woman that required emergent splenectomy. Recent case reports suggest that splenic rupture occurs in people without known risk factors for severe babesiosis. Physicians should be aware of this acute presentation in otherwise healthy individuals. (C) 2015 Elsevier GmbH. All rights reserved. C1 [Farber, F. R.; Robey, T. E.] Waterbury Hosp & Hlth Ctr, Waterbury, CT 06721 USA. [Farber, F. R.] Duke Univ, Durham, NC 27706 USA. [Muehlenbachs, A.] Ctr Dis Control, Atlanta, GA 30333 USA. [Robey, T. E.] Yale Univ, New Haven, CT 06520 USA. RP Robey, TE (reprint author), Waterbury Hosp & Hlth Ctr, Waterbury, CT 06721 USA. EM scienceandmedicine@gmail.com NR 16 TC 2 Z9 3 U1 0 U2 1 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2015 VL 6 IS 5 BP 649 EP 652 DI 10.1016/j.ttbdis.2015.05.010 PG 4 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA CO3AJ UT WOS:000359028300017 PM 26123434 ER PT J AU Payne, GH James, SD Hawley, L Corrigan, B Kramer, RE Overton, SN Farris, RP Wasilewski, Y AF Payne, Gayle Holmes James, Stephen D., Jr. Hawley, Lisa Corrigan, Bethany Kramer, Rachel E. Overton, Samantha N. Farris, Rosanne P. Wasilewski, Yvonne TI CDC's Health Equity Resource Toolkit: Disseminating Guidance for State Practitioners to Address Obesity Disparities SO HEALTH PROMOTION PRACTICE LA English DT Article DE health disparities; obesity; chronic disease; health promotion; nutrition; physical activity/exercise ID PREVALENCE; PROMOTION; ADULTS AB Obesity has been on the rise in the United States over the past three decades, and is high. In addition to population-wide trends, it is clear that obesity affects some groups more than others and can be associated with age, income, education, gender, race and ethnicity, and geographic region. To reverse the obesity epidemic, the Centers for Disease Control and Prevention) promotes evidence-based and practice-informed strategies to address nutrition and physical activity environments and behaviors. These public health strategies require translation into actionable approaches that can be implemented by state and local entities to address disparities. The Centers for Disease Control and Prevention used findings from an expert panel meeting to guide the development and dissemination of the Health Equity Resource Toolkit for State Practitioners Addressing Obesity Disparities (available at http://www.cdc.gov/obesity/health_equity/toolkit.html). The Toolkit helps public health practitioners take a systematic approach to program planning using a health equity lens. The Toolkit provides a six-step process for planning, implementing, and evaluating strategies to address obesity disparities. Each section contains (a) a basic description of the steps of the process and suggested evidence-informed actions to help address obesity disparities, (b) practical tools for carrying out activities to help reduce obesity disparities, and (c) a "real-world" case study of a successful state-level effort to address obesity with a focus on health equity that is particularly relevant to the content in that section. Hyperlinks to additional resources are included throughout. C1 [Payne, Gayle Holmes; Farris, Rosanne P.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [James, Stephen D., Jr.; Hawley, Lisa; Corrigan, Bethany; Kramer, Rachel E.; Overton, Samantha N.; Wasilewski, Yvonne] SciMetrika LLC, Durham, NC USA. RP Payne, GH (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway,Mailstop F-77, Atlanta, GA 30341 USA. EM gpayne@cdc.gov FU Intramural CDC HHS [CC999999]; PHS HHS [200-2008-27889] NR 18 TC 2 Z9 2 U1 1 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1524-8399 EI 1552-6372 J9 HEALTH PROMOT PRACT JI Health Promot. Pract. PD JAN PY 2015 VL 16 IS 1 BP 84 EP 90 DI 10.1177/1524839914538967 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CL9KZ UT WOS:000357298500012 PM 24962967 ER PT J AU Andrews, RN Keane, M Hanley, KW Feng, HA Ashley, K AF Andrews, Ronnee N. Keane, Michael Hanley, Kevin W. Feng, H. Amy Ashley, Kevin TI Manganese speciation of laboratory-generated welding fumes SO ANALYTICAL METHODS LA English DT Article ID SEQUENTIAL EXTRACTION; PARKINSONS-DISEASE; EXPOSURE; DYSFUNCTION; SOLUBILITY; PARTICLES; AEROSOLS; SEQUELAE; WELDERS; MN AB The objective of this laboratory study was to identify and measure manganese (Mn) fractions in chamber-generated welding fumes (WF) and to evaluate and compare the results from a sequential extraction procedure for Mn fractions with that of an acid digestion procedure for measurement of total, elemental Mn. To prepare Mn-containing particulate matter from representative welding processes, a welding system was operated in short circuit gas metal arc welding (GMAW) mode using both stainless steel (SS) and mild carbon steel (MCS) and also with flux cored arc welding (FCAW) and shielded metal arc welding (SMAW) using MCS. Generated WF samples were collected onto polycarbonate filters before homogenization, weighing and storage in scintillation vials. The extraction procedure consisted of four sequential steps to measure various Mn fractions based upon selective solubility: (1) soluble Mn dissolved in 0.01 M ammonium acetate; (2) Mn(0,II) dissolved in 25% (v/v) acetic acid; (3) Mn(III,IV) dissolved in 0.5% (w/v) hydroxylamine hydrochloride in 25% (v/v) acetic acid; and (4) insoluble Mn extracted with concentrated hydrochloric and nitric acids. After sample treatment, the four fractions were analyzed for Mn by inductively coupled plasma-atomic emission spectroscopy (ICP-AES). WF from GMAW and FCAW showed similar distributions of Mn species, with the largest concentrations of Mn detected in the Mn(0,II) and insoluble Mn fractions. On the other hand, the majority of the Mn content of SMAW fume was detected as Mn(III, IV). Although the concentration of Mn measured from summation of the four sequential steps was statistically significantly different from that measured from the hot block dissolution method for total Mn, the difference is small enough to be of no practical importance for industrial hygiene air samples, and either method may be used for Mn measurement. The sequential extraction method provides valuable information about the oxidation state of Mn in samples and allows for comparison to results from previous work and from total Mn dissolution methods. C1 [Andrews, Ronnee N.; Hanley, Kevin W.; Feng, H. Amy; Ashley, Kevin] NIOSH, US Dept HHS, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Keane, Michael] NIOSH, US Dept HHS, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Andrews, RN (reprint author), NIOSH, US Dept HHS, Ctr Dis Control & Prevent, 1090 Tusculum Ave, Cincinnati, OH 45226 USA. EM RAndrews@cdc.gov FU National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS); National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC) [NIEHS/NIOSH Interagency Agreement] [Y1-E5-9018-02] FX This study was partially funded by an interagency agreement between the National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS) and the National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC) [NIEHS/NIOSH Interagency Agreement no. Y1-E5-9018-02]. The authors wish to acknowledge Tami Wise, who provided outstanding technical assistance, and Dr Yngvar Thomassen (STAMI, Norway) who kindly shared manganese-containing alloy material for preliminary studies. NR 38 TC 1 Z9 1 U1 3 U2 8 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1759-9660 EI 1759-9679 J9 ANAL METHODS-UK JI Anal. Methods PY 2015 VL 7 IS 15 BP 6403 EP 6410 DI 10.1039/c5ay01147g PG 8 WC Chemistry, Analytical; Food Science & Technology; Spectroscopy SC Chemistry; Food Science & Technology; Spectroscopy GA CN5WU UT WOS:000358504400046 PM 26345630 ER PT J AU Prager, KC Alt, DP Buhnerkempe, MG Greig, DJ Galloway, RL Wu, QZ Gulland, FMD Lloyd-Smith, JO AF Prager, K. C. Alt, David P. Buhnerkempe, Michael G. Greig, Denise J. Galloway, Renee L. Wu, Qingzhong Gulland, Frances M. D. Lloyd-Smith, James O. TI Antibiotic Efficacy in Eliminating Leptospiruria in California Sea Lions (Zalophus californianus) Stranding with Leptospirosis SO AQUATIC MAMMALS LA English DT Article DE antibiotic; California sea lion; Zalophus californianus; Leptospira interrogans; leptospiruria; renal disease; chronic shedding ID INTERROGANS SEROVAR POMONA; ANTIMICROBIAL AGENTS; DIAGNOSIS; SUSCEPTIBILITIES; COAST; PCR; SEROPREVALENCE; DOXYCYCLINE; PINNIPEDS; THERAPY AB Stranded California sea lions (Zalophus californianus) along the California coast have been diagnosed with leptospirosis every year since at least the 1980s. Between September 2010 and November 2011, we followed 14 stranded California sea lions that survived to release and evaluated antibiotic efficacy in eliminating leptospiruria (urinary shedding of leptospires). Leptospiruria was assessed by real-time PCR of urine and urine culture, with persistence assessed using longitudinally collected samples. Serum chemistry was used to assess recovery of normal renal function. Microscopic agglutination testing (MAT) was performed to assess serum anti-Leptospira antibody titers, and the MAT reactivity patterns were consistent with L. interrogans serovar Pomona infection frequently observed in this population. Animals were initially treated for 6 to 16 d (median = 10.5; mean = 10.8) with antibiotics from the penicillin family, with some receiving additional antibiotics to treat other medical conditions. All urine cultures were negative; therefore, the presence of leptospiruria was assessed using PCR. Leptospiruria continued beyond the initial course of penicillin family antibiotics in 13 of the 14 sea lions, beyond the last antibiotic dose in 11 of the 14 sea lions, beyond recovery of renal function in 13 of the 14 sea lions, and persisted for at least 8 to 86 d (median = 45; mean = 46.8). Five animals were released with no negative urine PCR results detected; thus, their total shedding duration may have been longer. Cessation of leptospiruria was more likely in animals that received antibiotics for a greater duration, especially if coverage was uninterrupted. Real-time PCR results indicate that an antibiotic protocol commonly used to treat leptospirosis in rehabilitating California sea lions does not eliminate leptospiruria. It is possible that antibiotic protocols given for a longer duration and/or including other antibiotics may be effective in eliminating leptospiruria. These results may have important human and animal health implications, especially in rehabilitation facilities, as Leptospira transmission may occur through contact with animals with persistent leptospiruria. C1 [Prager, K. C.; Buhnerkempe, Michael G.; Lloyd-Smith, James O.] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA 90095 USA. [Prager, K. C.; Buhnerkempe, Michael G.; Lloyd-Smith, James O.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Alt, David P.] Natl Anim Dis Ctr, Infect Bacterial Dis Res Unit, Ames, IA 50010 USA. [Greig, Denise J.; Gulland, Frances M. D.] Marine Mammal Ctr, Sausalito, CA 94965 USA. [Galloway, Renee L.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Wu, Qingzhong] Natl Ocean Serv, Hollings Marine Lab, Charleston, SC 29412 USA. RP Prager, KC (reprint author), Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA 90095 USA. EM kcprager@ucla.edu RI Lloyd-Smith, James/K-4080-2012 OI Lloyd-Smith, James/0000-0001-7941-502X FU John H. Prescott Marine Mammal Rescue Assistance Grant Program; National Science Foundation [OCE-1335657]; De Logi Chair in Biological Sciences; RAPIDD program of the Science and Technology Directorate, Department of Homeland Security; Fogarty International Center, National Institutes of Health FX This work was supported by the John H. Prescott Marine Mammal Rescue Assistance Grant Program; the National Science Foundation (OCE-1335657); the De Logi Chair in Biological Sciences; and the RAPIDD program of the Science and Technology Directorate, Department of Homeland Security and the Fogarty International Center, National Institutes of Health. The authors thank the staff and volunteers at The Marine Mammal Center in Sausalito, California, as they were integral to sample collection, sample management, and treatment choice, particularly Jen Soper, Carlos Rios, and William Van Bonn. NR 36 TC 0 Z9 0 U1 3 U2 8 PU EUROPEAN ASSOC AQUATIC MAMMALS PI MOLINE PA C/O DR JEANETTE THOMAS, BIOLOGICAL SCIENCES, WESTERN ILLIONIS UNIV-QUAD CITIES, 3561 60TH STREET, MOLINE, IL 61265 USA SN 0167-5427 J9 AQUAT MAMM JI Aquat. Mamm. PY 2015 VL 41 IS 2 BP 203 EP 212 DI 10.1578/AM.41.2.2015.203 PG 10 WC Marine & Freshwater Biology; Zoology SC Marine & Freshwater Biology; Zoology GA CN3AZ UT WOS:000358296900008 ER PT J AU Afanou, KA Straumfors, A Skogstad, A Skaar, I Hjeljord, L Skare, O Green, BJ Tronsmo, A Eduard, W AF Afanou, Komlavi Anani Straumfors, Anne Skogstad, Asbjorn Skaar, Ida Hjeljord, Linda Skare, Oivind Green, Brett James Tronsmo, Arne Eduard, Wijnand TI Profile and Morphology of Fungal Aerosols Characterized by Field Emission Scanning Electron Microscopy (FESEM) SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID FALSE DISCOVERY RATE; RESPIRATORY DEPOSITION; TRICHOTHECENE MYCOTOXINS; ASPERGILLUS-FUMIGATUS; BUILDING-MATERIALS; AIR-FLOW; FRAGMENTS; CONIDIA; SPORES; PARTICLES AB Fungal aerosols consist of spores and fragments with diverse array of morphologies; however, the size, shape, and origin of the constituents require further characterization. In this study, we characterize the profile of aerosols generated from Aspergillus fumigatus, A. versicolor, and Penicillium chrysogenum grown for 8 weeks on gypsum boards. Fungal particles were aerosolized at 12 and 20 L min(-1) using the Fungal Spore Source Strength Tester (FSSST) and the Stami particle generator (SPG). Collected particles were analyzed with field emission scanning electron microscopy (FESEM). We observed spore particle fraction consisting of single spores and spore aggregates in four size categories, and a fragment fraction that contained submicronic fragments and three size categories of larger fragments. Single spores dominated the aerosols from A. fumigatus (median: 53%), while the submicronic fragment fraction was the highest in the aerosols collected from A. versicolor (median: 34%) and P. chrysogenum (median: 31%). Morphological characteristics showed near spherical particles that were only single spores, oblong particles that comprise some spore aggregates and fragments (<3.5 mu m), and fiber-like particles that regroup chained spore aggregates and fragments (>3.5 mu m). Further, the near spherical particles dominated the aerosols from A. fumigatus (median: 53%), while oblong particles were dominant in the aerosols from A. versicolor (68%) and P. chrysogenum (55%). Fiber-like particles represented 21% and 24% of the aerosols from A. versicolor and P. chrysogenum, respectively. This study shows that fungal particles of various size, shape, and origin are aerosolized, and supports the need to include a broader range of particle types in fungal exposure assessment. C1 [Afanou, Komlavi Anani; Straumfors, Anne; Skogstad, Asbjorn; Skare, Oivind; Eduard, Wijnand] Natl Inst Occupat Hlth, Dept Chem & Biol Work Environm, N-0033 Oslo, Norway. [Skaar, Ida] Norwegian Vet Inst, Sect Mycol, Oslo, Norway. [Hjeljord, Linda; Tronsmo, Arne] Norwegian Univ Life Sci, Inst Chem Biotechnol & Food Sci, As, Norway. [Green, Brett James] NIOSH, Ctr Dis Control & Prevent, Allergy & Clin Immunol Branch, Hlth Effect Lab Div, Morgantown, WV USA. RP Eduard, W (reprint author), Natl Inst Occupat Hlth, Dept Chem & Biol Work Environm, N-0033 Oslo, Norway. EM wijnand.eduard@stami.no RI Skare, Oivind/C-6330-2016 OI Skare, Oivind/0000-0001-8043-2820 FU Norwegian Research Council [NFR196130/H10] FX The present study is a part of the project "Fungal particles in indoor air" that is financially supported by the Norwegian Research Council: Grant number NFR196130/H10. NR 57 TC 3 Z9 3 U1 2 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0278-6826 EI 1521-7388 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PY 2015 VL 49 IS 6 BP 423 EP 435 DI 10.1080/02786826.2015.1040486 PG 13 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA CN4XI UT WOS:000358433400002 PM 26855468 ER PT J AU Liu, Y Pleasants, RA Croft, JB Wheaton, AG Heidari, K Malarcher, AM Ohar, JA Kraft, M Mannino, DM Strange, C AF Liu, Yong Pleasants, Roy A. Croft, Janet B. Wheaton, Anne G. Heidari, Khosrow Malarcher, Ann M. Ohar, Jill A. Kraft, Monica Mannino, David M. Strange, Charlie TI Smoking duration, respiratory symptoms, and COPD in adults aged >= 45 years with a smoking history SO INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE LA English DT Article DE tobacco use; chronic obstructive pulmonary disease; respiratory symptoms; population-based study ID OBSTRUCTIVE PULMONARY-DISEASE; GENDER-DIFFERENCES; LUNG-FUNCTION; CHRONIC-BRONCHITIS; UNITED-STATES; CIGARETTE-SMOKING; HEALTH; POPULATION; RISK; MEN AB Background: The purpose of this study was to assess the relationship of smoking duration with respiratory symptoms and history of chronic obstructive pulmonary disease (COPD) in the South Carolina Behavioral Risk Factor Surveillance System survey in 2012. Methods: Data from 4,135 adults aged >= 45 years with a smoking history were analyzed using multivariable logistic regression that accounted for sex, age, race/ethnicity, education, and current smoking status, as well as the complex sampling design. Results: The distribution of smoking duration ranged from 19.2% (1-9 years) to 36.2% (>= 30 years). Among 1,454 respondents who had smoked for >= 30 years, 58.3% were current smokers, 25.0% had frequent productive cough, 11.2% had frequent shortness of breath, 16.7% strongly agreed that shortness of breath affected physical activity, and 25.6% had been diagnosed with COPD. Prevalence of COPD and each respiratory symptom was lower among former smokers who quit >= 10 years earlier compared with current smokers. Smoking duration had a linear relationship with COPD (P<0.001) and all three respiratory symptoms (P<0.001) after adjusting for smoking status and other covariates. While COPD prevalence increased with prolonged smoking duration in both men and women, women had a higher age-adjusted prevalence of COPD in the 1-9 years, 20-29 years, and >= 30 years duration periods. Conclusion: These state population data confirm that prolonged tobacco use is associated with respiratory symptoms and COPD after controlling for current smoking behavior. C1 [Liu, Yong; Croft, Janet B.; Wheaton, Anne G.] Ctr Dis Control & Prevent, Div Populat Hlth, Atlanta, GA 30341 USA. [Pleasants, Roy A.] Duke Univ, Sch Med, Div Pulm Allergy & Crit Care Med, Durham, NC USA. [Heidari, Khosrow] Dept Hlth & Environm Control, Chron Dis Epidemiol Off, Columbia, SC USA. [Malarcher, Ann M.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA. [Ohar, Jill A.] Wake Forest Univ, Sect Pulm Crit Care Allergy & Immunol Dis, Winston Salem, NC 27109 USA. [Kraft, Monica] Univ Arizona, Dept Med, Phoenix, AZ USA. [Mannino, David M.] Univ Kentucky, Pulm Epidemiol Res Lab, Div Pulm Crit Care & Sleep Med, Lexington, KY USA. [Strange, Charlie] Med Univ S Carolina, Div Pulm Crit Care Allergy & Sleep Med, Charleston, SC 29425 USA. RP Liu, Y (reprint author), Ctr Dis Control & Prevent, Div Populat Hlth, 4770 Buford Highway NE,Mail Stop F-78, Atlanta, GA 30341 USA. EM ikd8@cdc.gov NR 39 TC 8 Z9 8 U1 1 U2 4 PU DOVE MEDICAL PRESS LTD PI ALBANY PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND SN 1178-2005 J9 INT J CHRONIC OBSTR JI Int. J. Chronic Obstr. Pulm. Dis. PY 2015 VL 10 BP 1409 EP 1416 DI 10.2147/COPD.S82259 PG 8 WC Respiratory System SC Respiratory System GA CN2WG UT WOS:000358282500001 PM 26229460 ER PT S AU Cogswell, ME Maalouf, J Elliott, P Loria, CM Patel, S Bowman, BA AF Cogswell, Mary E. Maalouf, Joyce Elliott, Paul Loria, Catherine M. Patel, Sheena Bowman, Barbara A. BE Bowman, BA Stover, PJ TI Use of Urine Biomarkers to Assess Sodium Intake: Challenges and Opportunities SO ANNUAL REVIEW OF NUTRITION, VOL 35 SE Annual Review of Nutrition LA English DT Review; Book Chapter DE 24 h; spot; overnight; balance; metabolism; sweat ID NIGHTTIME BLOOD-PRESSURE; CHRONIC KIDNEY-DISEASE; POPULATION SALT INTAKE; EXCESS DIETARY-SODIUM; POTASSIUM EXCRETION; CARDIOVASCULAR EVENTS; SOCCER PLAYERS; SWEAT RATE; REPRESENTATIVE SAMPLE; ELECTROLYTE EXCRETION AB This article summarizes current data and approaches to assess sodium intake in individuals and populations. A review of the literature on sodium excretion and intake estimation supports the continued use of 24-h urine collections for assessing population and individual sodium intake. Since 2000, 29 studies used urine biomarkers to estimate population sodium intake, primarily among adults. More than half used 24-h urine; the rest used a spot/casual, overnight, or 12-h specimen. Associations between individual sodium intake and health outcomes were investigated in 13 prospective cohort studies published since 2000. Only three included an indicator of long-term individual sodium intake, i.e., multiple 24-h urine specimens collected several days apart. Although not insurmountable, logistic challenges of 24-h urine collection remain a barrier for research on the relationship of sodium intake and chronic disease. Newer approaches, including modeling based on shorter collections, offer promise for estimating population sodium intake in some groups. C1 [Cogswell, Mary E.; Maalouf, Joyce; Patel, Sheena; Bowman, Barbara A.] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. [Maalouf, Joyce] IHRC Inc, Atlanta, GA 30346 USA. [Elliott, Paul] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London W21 PG, England. [Loria, Catherine M.] NHLBI, Div Cardiovasc Sci, NIH, Bethesda, MD 20892 USA. RP Cogswell, ME (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. EM mcogswell@cdc.gov; jmaalouf@cdc.gov; p.elliott@imperial.ac.uk; loriac@nhlbi.nih.gov; spatel@cdc.gov; bbowman@cdc.gov FU USDHHS; NIHR Biomedical Research Center at Imperial College Healthcare NHS Trust and Imperial College; NIHR Health Protection Research Unit on Health Impact of Environmental Hazards; MRC-PHE Center for Environment and Health FX The authors thank Katherine John, Joanna Taliano, and Lauren Clark for their help with the literature search and references, and Christine Pfeiffer, PhD for the helpful review and comments on the section on data collection and laboratory analysis. This work was supported by the USDHHS. Dr. Elliott acknowledges support from the NIHR Biomedical Research Center at Imperial College Healthcare NHS Trust and Imperial College, the NIHR Health Protection Research Unit on Health Impact of Environmental Hazards, and the MRC-PHE Center for Environment and Health. He is an NIHR Senior Investigator. NR 151 TC 6 Z9 6 U1 6 U2 10 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA SN 0199-9885 BN 978-0-8243-2835-1 J9 ANNU REV NUTR JI Annu. Rev. Nutr. PY 2015 VL 35 BP 349 EP + DI 10.1146/annurev-nutr-071714-034322 PG 41 WC Nutrition & Dietetics SC Nutrition & Dietetics GA BD1QC UT WOS:000358259600012 PM 25974702 ER PT J AU Anderson, LM Adeney, KL Shinn, C Safranek, S Buckner-Brown, J Krause, LK AF Anderson, Laurie M. Adeney, Kathryn L. Shinn, Carolynne Safranek, Sarah Buckner-Brown, Joyce Krause, L. Kendall TI Community coalition-driven interventions to reduce health disparities among racial and ethnic minority populations SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review ID RANDOMIZED CONTROLLED-TRIAL; DIABETES PREVENTION PROJECT; NEW-YORK-CITY; NEIGHBORHOOD-ASTHMA-COALITION; VIETNAMESE-AMERICAN CHILDREN; SUBSTANCE-ABUSE PREVENTION; PARTICIPATORY RESEARCH PARTNERSHIP; SMOKING-CESSATION INTERVENTIONS; ADDRESSING SOCIAL DETERMINANTS; CHRONIC DISEASE PREVENTION AB Background Racial and ethnic disparities in health status are pervasive at all stages of the life cycle. One approach to reducing health disparities involves mobilizing community coalitions that include representatives of target populations to plan and implement interventions for community level change. A systematic examination of coalition-led interventions is needed to inform decision making about the use of community coalition models. Objectives To assess effects of community coalition-driven interventions in improving health status or reducing health disparities among racial and ethnic minority populations. Search methods We searched MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, Social Science Citation Index, Dissertation Abstracts, System for Information on Grey Literature in Europe (SIGLE) (from January 1990 through September 30, 2013), and Global Health Library (from January 1990 through March 31, 2014). Selection criteria Cluster-randomized controlled trials, randomized controlled trials, quasi-experimental designs, controlled before-after studies, interrupted time series studies, and prospective controlled cohort studies. Only studies of community coalitions with at least one racial or ethnic minority group representing the target population and at least two community public or private organizations are included. Major outcomes of interest are direct measures of health status, as well as lifestyle factors when evidence indicates that these have an effect on the direct measures performed. Data collection and analysis Two review authors independently extracted data and assessed risk of bias for each study. Main results Fifty-eight community coalition-driven intervention studies were included. No study was considered to be at low risk of bias. Behavioral change outcomes and health status change outcomes were analyzed separately. Outcomes are grouped by intervention type. Pooled effects across intervention types are not presented because the diverse community coalition-led intervention studies did not examine the same constructs or relationships, and they used dissimilar methodological designs. Broad-scale community system level change strategies led to little or no difference in measures of health behavior or health status (very low-certainty evidence). Broad health and social care system level strategies leds to small beneficial changes in measures of health behavior or health status in large samples of community residents (very low-certainty evidence). Lay community health outreach worker interventions led to beneficial changes in health behavior measures of moderate magnitude in large samples of community residents (very low-certainty evidence). Lay community health outreach worker interventions may lead to beneficial changes in health status measures in large samples of community residents; however, results were not consistent across studies (low-certainty evidence). Group-based health education led by professional staff resulted in moderate improvement in measures of health behavior (very low-certainty evidence) or health status (low-certainty evidence). Adverse outcomes of community coalition-led interventions were not reported. Authors' conclusions Coalition-led interventions are characterized by connection of multi-sectoral networks of health and human service providers with ethnic and racial minority communities. These interventions benefit a diverse range of individual health outcomes and behaviors, as well as health and social care delivery systems. Evidence in this review shows that interventions led by community coalitions may connect health and human service providers with ethnic and racial minority communities in ways that benefit individual health outcomes and behaviors, as well as care delivery systems. However, because information on characteristics of the coalitions themselves is insufficient, evidence does not provide an explanation for the underlying mechanisms of beneficial effects. Thus, a definitive answer as to whether a coalition-led intervention adds extra value to the types of community engagement intervention strategies described in this review remains unattainable. C1 [Anderson, Laurie M.] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA. [Adeney, Kathryn L.] Washington State Inst Publ Policy, Epidemiol & Publ Hlth, Seattle, WA USA. [Shinn, Carolynne] New Hampshire Dept Hlth & Human Serv, New Hampshire Div Publ Hlth Serv, Concord, NH 03301 USA. [Safranek, Sarah] Univ Washington, Hlth Sci Lib, Seattle, WA 98195 USA. [Buckner-Brown, Joyce] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Community Hlth, Res Surveillance & Evaluat Branch, Atlanta, GA USA. [Krause, L. Kendall] Bill & Melinda Gates Fdn, Epidemiol & Surveillance Div, Seattle, WA USA. RP Anderson, LM (reprint author), Univ Washington, Sch Publ Hlth, Dept Epidemiol, POB 357236, Seattle, WA 98195 USA. EM LMAnder@u.washington.edu RI kiaie, fatemeh/I-6083-2016; kiaie, robabeh/I-2157-2016; OI kiaie, robabeh/0000-0001-5251-3201; Safranek, Sarah/0000-0002-6425-1939 FU International Union for Health Promotion and Education FX External sources; International Union for Health Promotion and Education, Other. NR 415 TC 1 Z9 1 U1 12 U2 36 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X EI 1361-6137 J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2015 IS 6 AR CD009905 DI 10.1002/14651858.CD009905.pub2 PG 190 WC Medicine, General & Internal SC General & Internal Medicine GA CM3TE UT WOS:000357606400049 PM 26075988 ER PT J AU Suchdev, PS Pena-Rosas, JP De-Regil, LM AF Suchdev, Parminder S. Pena-Rosas, Juan Pablo De-Regil, Luz Maria TI Multiple micronutrient powders for home (point-of-use) fortification of foods in pregnant women SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review ID CLUSTER-RANDOMIZED TRIAL; FOLIC-ACID; DOUBLE-BLIND; VITAMIN-A; INCOME COUNTRIES; NIGHT BLINDNESS; YOUNG-CHILDREN; BIRTH-WEIGHT; SUPPLEMENTATION; IRON AB Background It is estimated that 32 million pregnant women suffer from anaemia worldwide. Due to increased metabolic demands, pregnant women are particularly vulnerable to anaemia and vitamin and mineral deficiencies, leading to adverse health effects in both the mother and her baby. Despite the demonstrated benefits of prenatal supplementation with iron and folic acid or multiple micronutrients, poor adherence to routine supplementation has limited the effectiveness of this intervention in many settings. Micronutrient powders for point-of-use fortification are packed, single-dose sachets containing vitamins and minerals that can be added onto prepared food to improve its nutrient profile. The use of multiple micronutrient powders for point-of-use fortification of foods in pregnant women could be an alternative intervention to prenatal micronutrient supplementation. Objectives To assess the effects of prenatal home (point-of-use) fortification of foods with multiple micronutrient powders on maternal and newborn health. Search methods We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 January 2015) and the International Clinical Trials Registry Platform (ICTRP) (31 January 2015). We also contacted relevant agencies to identify ongoing and unpublished studies. Selection criteria Randomised controlled trials (both individual and cluster randomisation) and quasi-randomised trials, irrespective of language or publication status. The intervention was micronutrient powders for point-of-use fortification of foods, containing at least three micronutrients with one of them being iron, provided to pregnant women of any gestational age and parity. Five comparison groups were considered: no intervention/placebo, iron and folic acid supplements, iron-only supplements, folic-acid only supplements, and multiple micronutrients in supplements. Data collection and analysis Two review authors independently assessed the eligibility of studies, extracted and checked data accuracy, and assessed the risk of bias of included studies. Main results Our search identified 12 reports (relating to six studies). We included two cluster-randomised controlled trials (involving 1172 women) -these trials were considered to be at a moderate to high risk of bias due to methodological limitations. One trial is ongoing, and three studies were excluded. Micronutrient powders for point-of-use fortification of foods versus iron and folic acid supplements One trial (involving 478 pregnant women attending 42 antenatal care centres) compared micronutrient powders containing iron, folic acid, vitamin C and zinc with iron and folic acid tablets provided daily from 14 to 22 weeks to 32 weeks' gestation. The trial did not report on any of this review's primary outcomes: maternal anaemia at or near term, maternal iron deficiency, maternal mortality, adverse effects, low birthweight, preterm births. Nor did the trial report on the majority of this review's secondary outcomes, with the exception of maternal adherence. Adherence to micronutrient powders was lower than adherence to iron and folic acid supplements (risk ratio (RR) 0.76, 95% confidence interval (CI) 0.66 to 0.87, one study, n = 405). Micronutrient powders for point-of-use fortification of foods versus same multiple micronutrients in supplements One study (involving 694 pregnant women from 18 communities), compared micronutrient powders containing iron, folic acid, vitamin C, zinc, iodine, vitamin E and vitamin B-12 with tablets containing the same seven micronutrients. There was no difference in maternal anaemia at 37 weeks of gestation (RR 0.92, 95% CI 0.53 to 1.59, one study, n = 470, very low quality evidence). The trial did not report on any of this review's other primary outcomes in relation to maternal iron deficiency, maternal mortality, adverse effects, low birthweight, or preterm birth. In terms of this review's secondary outcomes, the included trial did not report on the majority of this review's prespecified secondary outcomes with one exception - there was no clear difference in maternal haemoglobin Hb or near term (mean difference (MD) 1.0 g/L, 95% CI -1.77 to 3.77, one study, n = 470). Authors' conclusions Limited evidence suggests that micronutrient powders for point-of-use fortification of foods have no clear difference as multiple micronutrient supplements on maternal anaemia (very low quality evidence) and Hb at or near term. There is limited evidence to suggest that women were more likely to adhere to taking tablets than using micronutrient powders. The overall quality of evidence was judged very low (due to methodological limitations), and no evidence was available for the majority of primary and secondary outcomes. Therefore, more evidence is needed to assess the potential benefits or harms of the use of micronutrient powders in pregnant women on maternal and infant health outcomes. Future trials should also assess adherence to micronutrient powders and be adequately powered to evaluate the effects on birth outcomes and morbidity. C1 [Suchdev, Parminder S.] Emory Univ, Ctr Dis Control & Prevent CDC, Pediat & Global Hlth, Nutr Branch, Atlanta, GA 30322 USA. [Pena-Rosas, Juan Pablo] WHO, Dept Nutr Hlth & Dev, Evidence & Programme Guidance, CH-1211 Geneva, Switzerland. [De-Regil, Luz Maria] Micronutrient Initiat, Res & Evaluat, Ottawa, ON, Canada. RP Suchdev, PS (reprint author), Emory Univ, Ctr Dis Control & Prevent CDC, Egleston Hosp, Pediat & Global Hlth,Nutr Branch, 1405 Clifton Rd,Ground Floor, Atlanta, GA 30322 USA. EM psuchde@emory.edu OI Pena-Rosas, Juan Pablo/0000-0002-6737-9831 FU Emory University, USA; US Centers for Disease Control and Prevention (CDC), Atlanta, GA; Evidence and Programme Guidance Unit, Department of Nutrition for Health and Development, World Health Organization, Switzerland; Micronutrient Initiative (MI), Canada; Micronutrient Initiative (MI); Bill & Melinda Gates Foundation, USA; Bill & Melinda Gates Foundation FX Internal sources; Emory University, USA.; Parminder Suchdev works as Associate Professor of Pediatrics for Emory University and receives salary support from the US Centers for Disease Control and Prevention (CDC), Atlanta, GA; Evidence and Programme Guidance Unit, Department of Nutrition for Health and Development, World Health Organization, Switzerland.; Micronutrient Initiative (MI), Canada.; External sources; Micronutrient Initiative (MI), Canada.; WHO acknowledges Micronutrient Initiative (MI) for their financial support to the Evidence and Programme Guidance Unit for the development and update of systematic reviews on nutrition and nutrition-sensitive interventions.; The Bill & Melinda Gates Foundation, USA.; WHO acknowledges The Bill & Melinda Gates Foundation for their financial support to the Evidence and Programme Guidance Unit for the development and update of systematic reviews of the evidence in nutrition and nutrition-sensitive interventions. NR 87 TC 1 Z9 1 U1 2 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X EI 1361-6137 J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2015 IS 6 AR CD011158 DI 10.1002/14651858.CD011158.pub2 PG 40 WC Medicine, General & Internal SC General & Internal Medicine GA CM3TE UT WOS:000357606400071 PM 26091836 ER PT J AU Cunningham, TJ Ford, ES Rolle, IV Wheaton, AG Croft, JB AF Cunningham, Timothy J. Ford, Earl S. Rolle, Italia V. Wheaton, Anne G. Croft, Janet B. TI Associations of Self-Reported Cigarette Smoking with Chronic Obstructive Pulmonary Disease and Co-Morbid Chronic Conditions in the United States SO COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE LA English DT Article DE COPD; chronic disease; cross-sectional studies; smoking; tobacco use ID COMORBIDITIES; PREVALENCE; RISK; MORTALITY; IMPACT AB Background: The question of how smoking, COPD, and other chronic diseases are related remains unresolved. Therefore, we examined relationships between smoking, COPD, and 10 other chronic diseases and assessed the prevalence of co-morbid chronic conditions among people with COPD. Methods: We analyzed cross-sectional data from 405,856 US adults aged 18 years or older in the 2011 Behavioral Risk Factor Surveillance System. We used log-linear regression to estimate prevalence ratios (PRs) and their corresponding 95% confidence intervals (CIs) for these relationships adjusting for age, gender, race/ethnicity, marital status, educational attainment, annual household income, and health insurance coverage. Results: Overall, 17.5% reported being current cigarette smokers, 6.9% reported having COPD, and 71.2% reported another chronic condition. After age-adjustment, prevalence of COPD was 14.1% (adjusted PR = 3.9; 95% CI: 3.7, 4.1) among current smokers and 7.1% (adjusted PR = 2.5; 95% CI: 2.4, 2.7) among former smokers compared to 2.9% among never smokers. The most common chronic conditions among current smokers after age-adjustment were high cholesterol (36.7%), high blood pressure (34.6%), arthritis (29.4%), depression (27.4%), and asthma (16.9%). In separate multivariable models, smoking and COPD were associated with each of the 10 other chronic conditions (p < 0.05), which also included cancer, coronary heart disease, diabetes, kidney disease, and stroke; COPD modified associations between smoking and co-morbidities, while smoking did not modify associations between COPD and co-morbidities. Conclusions: Our findings confirm previous evidence and highlight the continuing importance of comprehensive care coordination for people with COPD and co-morbid chronic conditions and also tobacco prevention and control strategies. C1 [Cunningham, Timothy J.; Ford, Earl S.; Wheaton, Anne G.; Croft, Janet B.] Ctr Dis Control & Prevent, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Rolle, Italia V.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Cunningham, TJ (reprint author), Ctr Dis Control & Prevent, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Hwy,Mailstop F78, Atlanta, GA 30341 USA. EM TJCunningham@cdc.gov FU Intramural CDC HHS [CC999999] NR 25 TC 8 Z9 8 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1541-2555 EI 1541-2563 J9 COPD JI COPD-J. Chronic Obstr. Pulm. Dis. PY 2015 VL 12 IS 3 BP 276 EP 286 DI 10.3109/15412555.2014.949001 PG 11 WC Respiratory System SC Respiratory System GA CL8SY UT WOS:000357245600007 PM 25207639 ER PT J AU Hook, SA Nelson, CA Mead, PS AF Hook, Sarah A. Nelson, Christina A. Mead, Paul S. TI US public's experience with ticks and tick-borne diseases: Results from national HealthStyles surveys SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE Tick-borne disease; Lyme disease; Prevention; Tick exposure ID IXODES-SCAPULARIS ACARI; EARLY LYME-DISEASE; ANTIBIOTIC-TREATMENT; CONTROLLED-TRIAL; ENDEMIC AREA; PREVENTION; ATTITUDES; DURATION; BEHAVIORS; INFECTION AB Surveillance data indicate that tick-borne diseases (TBDs) are a substantial public health problem in the United States, yet information on the frequency of tick exposure and TBD awareness and prevention practices among the general population is limited. The objective of this study was to gain a more complete understanding of the U.S. public's experience with TBDs using data from annual, nationally representative HealthStyles surveys. There were 4728 respondents in 2009, 4050 in 2011, and 3503 in 2012. Twenty-one percent of respondents reported that a household member found a tick on his or her body during the previous year; of these, 10.1% reported consultation with a health care provider as a result. Overall, 63.7% of respondents reported that Lyme disease (LD) occurs in the area where they live, including 49.4% of respondents from the West South Central and 51.1% from the Mountain regions where LD does not occur. Conversely, in the New England and Mid-Atlantic regions where LD, anaplasmosis, and babesiosis are common, 13.9% and 20.8% of respondents, respectively, reported either that no TBDs occur in their area or that they had not heard of any of these diseases. The majority of respondents (51.2%) reported that they did not routinely take any personal prevention steps against tick bites during warm weather. Results from these surveys indicate that exposure to ticks is common and awareness of LD is widespread. Nevertheless, use of TBD prevention measures is relatively infrequent among the U.S. public, highlighting the need to better understand barriers to use of prevention measures. Published by Elsevier GmbH. C1 [Hook, Sarah A.; Nelson, Christina A.; Mead, Paul S.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Hook, SA (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, 3156 Rampart Rd, Ft Collins, CO 80521 USA. EM shook@cdc.gov; cnelson2@cdc.gov; pmead@cdc.gov NR 43 TC 8 Z9 8 U1 3 U2 5 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2015 VL 6 IS 4 BP 483 EP 488 DI 10.1016/j.ttbdis.2015.03.017 PG 6 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA CM0HO UT WOS:000357359200008 PM 25887156 ER PT B AU Phalen, RF Mendez, LB Oldham, MJ AF Phalen, Robert F. Mendez, Loyda B. Oldham, Michael J. BE Salem, H Katz, SA TI Nose-Only Aerosol Exposure Systems Design, Operation, and Performance SO INHALATION TOXICOLOGY, 3RD EDITION LA English DT Article; Book Chapter ID COMPUTATIONAL FLUID-DYNAMICS; RAT NASAL PASSAGES; SMALL LABORATORY-ANIMALS; INSPIRATORY AIR-FLOW; INHALATION EXPOSURE; F344 RAT; RESPIRATORY RESPONSES; DEPOSITION; DOSIMETRY; PARTICLES C1 [Phalen, Robert F.] Univ Calif Irvine, Ctr Dis Control & Prevent, Hlth Effects Lab Div, Irvine, CA 92697 USA. [Mendez, Loyda B.] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92717 USA. [Oldham, Michael J.] Virginia Commonwealth Univ, Altria Client Serv, Regulatory Affairs, Richmond, VA USA. RP Phalen, RF (reprint author), Univ Calif Irvine, Ctr Dis Control & Prevent, Hlth Effects Lab Div, Irvine, CA 92697 USA. NR 59 TC 1 Z9 1 U1 1 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-5274-6; 978-1-4665-5273-9 PY 2015 BP 43 EP 56 PG 14 WC Toxicology SC Toxicology GA BC7ZJ UT WOS:000355432100004 ER PT B AU Li, AP Richter, P Cole, S Madren-Whalley, J Oyler, J Dorsey, R Salem, H AF Li, Albert P. Richter, Patricia Cole, Stephanie Madren-Whalley, Janna Oyler, Jonathan Dorsey, Russell Salem, Harry BE Salem, H Katz, SA TI Pulmonary Primary Cells Cocultured in a Novel Cell Culture System, the Integrated Discrete Multiple Cell-Type Coculture System (IdMOC) Pulmonary Cytotoxicity of Eight Cigarette Smoke Condensates and Nicotine SO INHALATION TOXICOLOGY, 3RD EDITION LA English DT Article; Book Chapter ID CIGARETTE-SMOKE CONDENSATE; BRONCHIAL EPITHELIAL-CELLS; FLIGHT MASS-SPECTROMETRY; IN-VITRO; MAINSTREAM SMOKE; COMPARATIVE CYTOTOXICITY; XENOBIOTIC TOXICITY; BIOLOGICAL-ACTIVITY; HUMAN HEPATOCYTES; TOBACCO-SMOKE C1 [Li, Albert P.] In Vitro ADMET Labs LLC, Columbia, MD 21045 USA. [Richter, Patricia] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA USA. [Cole, Stephanie; Madren-Whalley, Janna; Dorsey, Russell; Salem, Harry] US Army, Edgewood Chem Biol Ctr, Aberdeen, MD USA. [Oyler, Jonathan] US Army, Med Res Inst Chem Def, Aberdeen, MD USA. RP Li, AP (reprint author), In Vitro ADMET Labs LLC, Columbia, MD 21045 USA. NR 50 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-5274-6; 978-1-4665-5273-9 PY 2015 BP 327 EP 338 PG 12 WC Toxicology SC Toxicology GA BC7ZJ UT WOS:000355432100017 ER PT J AU Powers, AM AF Powers, Ann M. TI Risks to the Americas associated with the continued expansion of chikungunya virus SO JOURNAL OF GENERAL VIROLOGY LA English DT Review ID AEDES-AEGYPTI; INFECTION; OUTBREAK; SEROPREVALENCE; MOSQUITO; REGION; ISLAND AB Chikungunya virus is a mosquito-borne virus that has been responsible for over 2 million human infections during the past decade. This virus, which previously had a geographical range primarily restricted to sub-Saharan Africa, the Indian subcontinent and South East Asia, has recently moved to subtropical latitudes as well as the western hemisphere. This expansion into novel habitats brings unique risks associated with further spread of the virus and the disease it causes. C1 Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Powers, AM (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. EM APowers@cdc.gov NR 23 TC 14 Z9 15 U1 0 U2 4 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 EI 1465-2099 J9 J GEN VIROL JI J. Gen. Virol. PD JAN PY 2015 VL 96 BP 1 EP 5 DI 10.1099/vir.0.070136-0 PN 1 PG 5 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA CJ8WQ UT WOS:000355784600001 PM 25239764 ER PT J AU Collier, SA Wade, TJ Sams, EA Hlavsa, MC Dufour, AP Beach, MJ AF Collier, Sarah A. Wade, Timothy J. Sams, Elizabeth A. Hlavsa, Michele C. Dufour, Alfred P. Beach, Michael J. TI Swimming in the USA: beachgoer characteristics and health outcomes at US marine and freshwater beaches SO JOURNAL OF WATER AND HEALTH LA English DT Article DE gastrointestinal illness; health outcomes; healthcare utilization; natural waters; recreational water; swimming ID RAPIDLY MEASURED INDICATORS; UNITED-STATES; RECREATIONAL WATER; DISEASE OUTBREAKS; OTITIS-EXTERNA; ILLNESS; QUALITY; RISK; SURVEILLANCE; PATHOGENS AB Swimming in lakes and oceans is popular, but little is known about the demographic characteristics, behaviors, and health risks of beachgoers on a national level. Data from a prospective cohort study of beachgoers at multiple marine and freshwater beaches in the USA were used to describe beachgoer characteristics and health outcomes for swimmers and non-swimmers. This analysis included 54,250 participants. Most (73.2%) entered the water; of those, 65.1% put their head under water, 41.3% got water in their mouth and 18.5% swallowed water. Overall, 16.3% of beachgoers reported any new health problem. Among swimmers, 6.6% reported gastrointestinal (GI) illness compared with 5.5% of non-swimmers (unadjusted chi(2) p < 0.001); 6.0% of swimmers and 4.9% of non-swimmers reported respiratory illness (p < 0.001); 1.8% of swimmers and 1.0% of non-swimmers reported ear problems (p < 0.001); and 3.9% of swimmers and 2.4% of non-swimmers experienced a rash (p < 0.001). Overall, swimmers reported a higher unadjusted incidence of GI illness and earaches than nonswimmers. Current surveillance systems might not detect individual cases and outbreaks of illness associated with swimming in natural water. Better knowledge of beachgoer characteristics, activities, and health risks associated with swimming in natural water can improve disease surveillance and prioritize limited resources. C1 [Collier, Sarah A.; Hlavsa, Michele C.; Beach, Michael J.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Wade, Timothy J.; Sams, Elizabeth A.] US EPA, Off Res & Dev, Chapel Hill, NC USA. [Dufour, Alfred P.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. RP Collier, SA (reprint author), Ctr Dis Control & Prevent, Mailstop C-09,1600 Clifton Rd, Atlanta, GA 30333 USA. EM SCollier@cdc.gov FU Intramural CDC HHS [CC999999] NR 30 TC 3 Z9 3 U1 1 U2 8 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1477-8920 J9 J WATER HEALTH JI J. Water Health PY 2015 VL 13 IS 2 BP 531 EP 543 DI 10.2166/wh.2014.095 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health; Microbiology; Water Resources SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Microbiology; Water Resources GA CK2ET UT WOS:000356024100022 PM 26042984 ER PT J AU Mahmoudi, MR Nazemalhosseini-Mojarad, E Kazemi, B Haghighi, A Mirzaei, A Mohammadiha, A Jahantab, S Xiao, L Karanis, P AF Mahmoudi, M. R. Nazemalhosseini-Mojarad, E. Kazemi, B. Haghighi, A. Mirzaei, A. Mohammadiha, A. Jahantab, S. Xiao, L. Karanis, P. TI Cryptosporidium genotypes and subtypes distribution in river water in Iran SO JOURNAL OF WATER AND HEALTH LA English DT Article DE Cryptosporidium spp.; environmental samples; Iran; subtype ID RIBOSOMAL-RNA GENE; NESTED-PCR-RFLP; MOLECULAR CHARACTERIZATION; SUBGENOTYPE ANALYSIS; PROTOZOAN PARASITES; SURFACE-WATER; CHILDREN; TRANSMISSION; GIARDIA; SAMPLES AB Little is known about the diversity and public health significance of Cryptosporidium species in river waters in Iran. In the present study, we determined the genotype and subtype distribution of Cryptosporidium spp. in river water samples in Iran. A total of 49 surface water samples were collected from rivers and surface water in Guilan and Tehran provinces during 2009-2010. Water samples were filtrated through a 1.2-mu m pore size membrane filter or by Filta-Max filter followed by immunomagnetic separation or sucrose purification methods. Genotype and subtype of Cryptosporidium were identified by sequence analysis of the 18S rRNA and 60 kDa glycoprotein (gp60) genes, respectively. A total of 24 (48.97%) water samples were positive for Cryptosporidium species by the 18sRNA-based polymerase chain reaction (PCR)-sequencing technique. DNA sequencing revealed the presence of five species of Cryptosporidium (C. parvum, C. hominis, C. muris, C. andersoni, and C. canis) in the water samples of the study area and, to our knowledge, the first report of C. muris in Iran. The results of GP60 gene analysis showed that all C. parvum and C. hominis isolates belonged to the IId and Id subtype families, respectively. The investigated river water supplies were heavily contaminated by pathogenic species of Cryptosporidium from humans and livestock. There is potential risk of waterborne cryptosporidiosis in humans and animals. C1 [Mahmoudi, M. R.] Guilan Univ Med Sci, Dept Microbiol, Fac Med, Rasht, Iran. [Nazemalhosseini-Mojarad, E.] Shahid Beheshti Univ Med Sci, Gastroenterol & Liver Dis Res Ctr, Tehran, Iran. [Mahmoudi, M. R.; Kazemi, B.] Shahid Beheshti Univ Med Sci, Res Ctr Cellular & Mol Biol, Tehran, Iran. [Mahmoudi, M. R.; Haghighi, A.; Mohammadiha, A.] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Parasitol & Mycol, Tehran, Iran. [Mirzaei, A.] Iilam Univ Med Sci, Dept Parasitol, Sch Med, Iilam, Iran. [Jahantab, S.] Tehran Prov Water & Wastewater Co TPWW, Tehran, Iran. [Xiao, L.] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Publ Hlth Serv, Atlanta, GA USA. [Karanis, P.] Qinghai Univ, Sch Med, CBID, Qinghai Acad Anim & Vet Sci, Quinghai, Peoples R China. RP Mahmoudi, MR (reprint author), Guilan Univ Med Sci, Dept Microbiol, Fac Med, Rasht, Iran. EM mrmahmoodi2002@yahoo.com RI Xiao, Lihua/B-1704-2013; Kazemi, Bahram/F-2785-2016 OI Xiao, Lihua/0000-0001-8532-2727; Mirzaei, Asad/0000-0002-4154-6603; Kazemi, Bahram/0000-0002-3072-8831 FU Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences and Tehran Province Water & Wastewater Co. (TPWW); University of the author P. Karanis in Germany, Cologne FX We would like to express our appreciation to Mrs Jahantab, Mrs Raesiyan, Mrs Parvar, and Isaia Sotiriadou for their kind cooperation and assistance. This work was supported and funded by the Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences and Tehran Province Water & Wastewater Co. (TPWW), and by the host University of the author P. Karanis in Germany, Cologne. NR 27 TC 2 Z9 3 U1 1 U2 8 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1477-8920 J9 J WATER HEALTH JI J. Water Health PY 2015 VL 13 IS 2 BP 600 EP 606 DI 10.2166/wh.2014.234 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Microbiology; Water Resources SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Microbiology; Water Resources GA CK2ET UT WOS:000356024100028 PM 26042990 ER PT J AU Hutchins, SS Brown, C Mayberry, R Sollecito, W AF Hutchins, Sonja S. Brown, Cedric Mayberry, Robert Sollecito, William TI Value of a small control group for estimating intervention effectiveness: results from simulations of immunization effectiveness studies SO JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH LA English DT Article DE community intervention study; effectiveness study; immunization effectiveness study; small control group; small sample size ID COMMUNITY-PREVENTIVE-SERVICES; DESIGN; STATISTICS; PROGRAM; TRIALS AB Aim: To improve evidence for public health practice, the conduct of effectiveness studies by practitioners is needed and may be stimulated if knowledge that smaller than usual samples may provide the same reliability of intervention effect size as larger samples. Materials & methods: We examined reliability of intervention effect using computerized simulations of 2000 hypothetical immunization effectiveness studies from an actual study population and by small (30 and 60) and larger (100 and 200) control groups compared with an intervention group of 200 participants. Results & conclusion: Across simulated studies, the mean intervention effect (14%) and effect sizes were equivalent regardless of control group size and equal to the actual study effect. These results are relevant for similarly designed and executed studies and indicate that studies with smaller control groups can generate valid and accurate evidence for effective public health practice in communities. C1 [Hutchins, Sonja S.] Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Equ, Atlanta, GA 30333 USA. [Brown, Cedric] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Mayberry, Robert] Morehouse Sch Med, Dept Community Hlth & Prevent Med, Atlanta, GA 30310 USA. [Sollecito, William] Univ N Carolina, Publ Hlth Leadership Program, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA. RP Hutchins, SS (reprint author), Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Equ, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM ssh1@cdc.gov NR 38 TC 0 Z9 0 U1 0 U2 0 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 2042-6305 EI 2042-6313 J9 J COMP EFFECT RES JI J. Comp. Eff. Res. PY 2015 VL 4 IS 3 BP 227 EP 238 DI 10.2217/cer.15.11 PG 12 WC Health Care Sciences & Services SC Health Care Sciences & Services GA CJ7TB UT WOS:000355701500006 ER PT J AU Chao, DY Crill, WD Davis, BS Chang, GJJ AF Chao, Day-Yu Crill, Wayne D. Davis, Brent S. Chang, Gwong-Jen J. TI Can reductions in the cross-reactivity of flavivirus structural proteins lead to improved safety and immunogenicity of tetravalent dengue vaccine? SO FUTURE VIROLOGY LA English DT Editorial Material DE antibody; cross-reactivity; dengue; flavivirus; neutralization; vaccine ID VIRUS-INFECTION; ANTIBODIES C1 [Chao, Day-Yu] Natl Chung Hsing Univ, Coll Vet Med, Grad Inst Microbiol & Publ Hlth, Taichung 401, Taiwan. [Crill, Wayne D.; Davis, Brent S.; Chang, Gwong-Jen J.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Chang, GJJ (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. EM gxc7@cdc.gov NR 20 TC 1 Z9 1 U1 0 U2 0 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 1746-0794 EI 1746-0808 J9 FUTURE VIROL JI Future Virol. PY 2015 VL 10 IS 5 BP 477 EP 480 DI 10.2217/FVL.15.13 PG 4 WC Virology SC Virology GA CJ1TA UT WOS:000355266200004 ER PT J AU Manore, CA Hickmann, KS Hyman, JM Foppa, IM Davis, JK Wesson, DM Mores, CN AF Manore, Carrie A. Hickmann, Kyle S. Hyman, James M. Foppa, Ivo M. Davis, Justin K. Wesson, Dawn M. Mores, Christopher N. TI A network-patch methodology for adapting agent-based models for directly transmitted disease to mosquito-borne disease SO JOURNAL OF BIOLOGICAL DYNAMICS LA English DT Article DE individual-based model; patch; network; chikungunya; mosquito-borne disease; dengue; differential equationsmodel; 92D30; 37C10; 92D40 ID RIFT-VALLEY FEVER; HUMAN MOVEMENT; MALARIA TRANSMISSION; MATHEMATICAL-MODEL; VIRUS; DYNAMICS; SIMULATION; INFLUENZA; AFRICA; SPREAD AB Mosquito-borne diseases cause significant public health burden and are widely re-emerging or emerging. Understanding, predicting, and mitigating the spread of mosquito-borne disease in diverse populations and geographies are ongoing modelling challenges. We propose a hybrid network-patch model for the spread of mosquito-borne pathogens that accounts for individual movement through mosquito habitats, extending the capabilities of existing agent-based models (ABMs) to include vector-borne diseases. The ABM are coupled with differential equations representing 'clouds' of mosquitoes in patches accounting for mosquito ecology. We adapted an ABM for humans using this method and investigated the importance of heterogeneity in pathogen spread, motivating the utility of models of individual behaviour. We observed that the final epidemic size is greater in patch models with a high risk patch frequently visited than in a homogeneous model. Our hybrid model quantifies the importance of the heterogeneity in the spread of mosquito-borne pathogens, guiding mitigation strategies. C1 [Manore, Carrie A.; Hickmann, Kyle S.; Hyman, James M.] Tulane Univ, Dept Math, Ctr Computat Sci, New Orleans, LA 70118 USA. [Foppa, Ivo M.] CDC, Battelle Epidemiol & Prevent Branch, Influenza Div, Atlanta, GA 30333 USA. [Davis, Justin K.; Wesson, Dawn M.] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Trop Med, New Orleans, LA 70118 USA. [Mores, Christopher N.] Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Vector Borne Dis Labs,Ctr Expt Infect Dis Res, Baton Rouge, LA 70803 USA. RP Manore, CA (reprint author), Tulane Univ, Dept Math, Ctr Computat Sci, New Orleans, LA 70118 USA. EM cmanore@tulane.edu; khickma@tulane.edu; mhyman@tulane.edu; ifoppa0417@gmail.com; jdavis37@tulane.edu; wesson@tulane.edu; cmores@lsu.edu FU NIH/NIGMS grant in the Models of Infectious Disease Agent Study (MIDAS) program [U01-GM097661-01]; NSF MPS Division of Mathematical Sciences NSF/MPS/DMS grant [DMS-1122666]; NSF SEES Fellow grant [CHE-1314029]; NIH/NIGMS MIDAS grant [U01-GM097658] FX CM and JH are partially supported through grants from the NIH/NIGMS grant in the Models of Infectious Disease Agent Study (MIDAS) program, U01-GM097661-01 and CM is partially supported by the NSF MPS Division of Mathematical Sciences NSF/MPS/DMS grant DMS-1122666 and by NSF SEES Fellow grant CHE-1314029. KH is partially supported by NIH/NIGMS MIDAS grant U01-GM097658. NR 36 TC 4 Z9 6 U1 7 U2 44 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1751-3758 EI 1751-3766 J9 J BIOL DYNAM JI J. Biol. Dyn. PD JAN 1 PY 2015 VL 9 IS 1 BP 52 EP 72 DI 10.1080/17513758.2015.1005698 PG 21 WC Ecology; Mathematical & Computational Biology SC Environmental Sciences & Ecology; Mathematical & Computational Biology GA CJ1KX UT WOS:000355243600001 PM 25648061 ER PT J AU Gomez-Alvarez, V Humrighouse, BW Revetta, RP Domingo, JWS AF Gomez-Alvarez, Vicente Humrighouse, Ben W. Revetta, Randy P. Domingo, Jorge W. Santo TI Bacterial composition in a metropolitan drinking water distribution system utilizing different source waters SO JOURNAL OF WATER AND HEALTH LA English DT Article DE bacterial diversity; drinking water bacteria; 16S rRNA gene sequencing ID COMMUNITY STRUCTURE; BIOFILMS; MYCOBACTERIA; ECOLOGY; CHLORINATION; DIVERSITY; PROTOZOA; RNA AB We investigated the bacterial composition of water samples from two service areas within a drinking water distribution system (DWDS), each associated with a different primary source of water (groundwater, GW; surface water, SW) and different treatment process. Community analysis based on 16S rRNA gene clone libraries indicated that Actinobacteria (Mycobacterium spp.) and alpha-Proteobacteria represented nearly 43 and 38% of the total sequences, respectively. Sequences closely related to Legionella, Pseudomonas, and Vibrio spp. were also identified. In spite of the high number of sequences (71%) shared in both areas, multivariable analysis revealed significant differences between the GW and SW areas. While the dominant phylotypes where not significantly contributing in the ordination of samples, the populations associated with the core of phylotypes (1-10% in each sample) significantly contributed to the differences between both service areas. Diversity indices indicate that the microbial community inhabiting the SW area is more diverse and contains more distantly related species coexisting with local assemblages as compared with the GW area. The bacterial community structure of SW and GW service areas were dissimilar, suggesting that their respective source water and/or water quality parameters shaped by the treatment processes may contribute to the differences in community structure observed. C1 [Gomez-Alvarez, Vicente; Revetta, Randy P.; Domingo, Jorge W. Santo] US EPA, Cincinnati, OH 45268 USA. [Humrighouse, Ben W.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH USA. [Humrighouse, Ben W.] US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Domingo, JWS (reprint author), US EPA, Cincinnati, OH 45268 USA. EM santodomingo.jorge@epa.gov FU US Environmental Protection Agency FX This work was funded by a Traineeship Award from the US Environmental Protection Agency to BWH. Special thanks to Jeff Swertfeger from the Greater Cincinnati Water Work (GCWW) for helping in the logistics of the water collection, to the Greater Cincinnati Water Work personnel for helping in the water collection and Margaret Kupferle and Daniel Oerther for revising initial drafts of this manuscript. The opinions expressed in this paper are those of the authors, and do not necessarily reflect the official positions and policies of the US Environmental Protection Agency. Any mention of product or trade names does not constitute recommendation for use by the US Environmental Protection Agency. NR 37 TC 5 Z9 5 U1 2 U2 21 PU IWA PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1477-8920 J9 J WATER HEALTH JI J. Water Health PY 2015 VL 13 IS 1 BP 140 EP 151 DI 10.2166/wh.2014.057 PG 12 WC Environmental Sciences; Public, Environmental & Occupational Health; Microbiology; Water Resources SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Microbiology; Water Resources GA CJ0QY UT WOS:000355183800014 PM 25719474 ER PT J AU Secor, WE Montgomery, SP AF Secor, W. Evan Montgomery, Susan P. TI Something old, something new: is praziquantel enough for schistosomiasis control? SO FUTURE MEDICINAL CHEMISTRY LA English DT Editorial Material DE mass drug administration; praziquantel; schistosomiasis ID HIGH-RISK COMMUNITIES; UROGENITAL SCHISTOSOMIASIS; MANSONI INFECTION; HAEMATOBIUM; IMPACT; KENYA; TRANSMISSION; REINFECTION; EFFICACY; DISTRICT C1 [Secor, W. Evan; Montgomery, Susan P.] Ctr Dis Control & Prevent, Parasit Dis Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30329 USA. RP Secor, WE (reprint author), Ctr Dis Control & Prevent, Parasit Dis Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, 1600 Clifton Rd NE, Atlanta, GA 30329 USA. EM was4@cdc.gov FU Intramural CDC HHS [CC999999] NR 19 TC 6 Z9 6 U1 1 U2 7 PU FUTURE SCI LTD PI LONDON PA UNITED HOUSE, 2 ALBERT PL, LONDON, N3 1QB, ENGLAND SN 1756-8919 EI 1756-8927 J9 FUTURE MED CHEM JI Future Med. Chem. PY 2015 VL 7 IS 6 BP 681 EP 684 DI 10.4155/FMC.15.9 PG 4 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA CI7JN UT WOS:000354939500003 PM 25996059 ER PT J AU Harmon, JR Scott, MC Baker, EM Jones, CJ Hickling, GJ AF Harmon, Jessica R. Scott, M. Cathy Baker, Ellen M. Jones, Carl J. Hickling, Graham J. TI Molecular identification of Ehrlichia species and host bloodmeal source in Amblyomma americanum L. from two locations in Tennessee, United States SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE Amblyomma americanum; Bloodmeal analysis; Ehrlichiosis; Tick-borne disease; Wildlife reservoir ID WHITE-TAILED DEER; POLYMERASE-CHAIN-REACTION; IXODES-RICINUS TICKS; ETIOLOGIC AGENT; ODOCOILEUS-VIRGINIANUS; RETIREMENT COMMUNITY; CYTOCHROME-B; CHAFFEENSIS; IXODIDAE; ACARI AB The current status of tick-borne diseases in the southeastern United States is challenging to define due to emerging pathogens, uncertain tick/host relationships, and changing disease case definitions. A golf-oriented retirement community on the Cumberland Plateau in Tennessee experienced an ehrlichiosis outbreak in 1993, prompting efforts to reduce the local tick population using '4-Poster' acaricide devices targeting white-tailed deer (Odocoileus virginianus). In 2009, the prevalence of Ehrlichia spp. in questing ticks was surveyed in the area and compared to a Tennessee state park where acaricide had not been applied. The range of wildlife hosts that immature Amblyomma americanum fed upon and the role that these hosts may play in pathogen dynamics were investigated using a reverse line blot (RLB) bloodmeal analysis technique. Amblyomma americanum was by far the most common tick species in both study areas (>99% of ticks collected). Of 303 adult and nymphal A. americanum tested at the retirement community, six were positive for Ehrlichia chaffeensis (2.0%), 16 were positive for E. ewingii (5.3%), and six were positive for Panola Mountain Ehrlichia (2.0%). This is the first confirmation of Panola Mountain Ehrlichia in A. americanum from the state of Tennessee. The 9.3% prevalence of Ehrlichia spp. in ticks from the retirement community was similar to that detected at the state park site (5.5%), suggesting that the 4-Poster treatment had not been sufficient to reduce Ehrlichia spp. cycling in the tick population. At both study sites, A. americanum fed on a wide range of mammal and bird species, with a minority of detectable bloodmeals coming from deer. Of the Ehrlichia-infected nymphs with positive bloodmeal identification, none fed on deer, indicating that multiple vertebrate species are contributing to sylvatic maintenance of Ehrlichia spp. at these sites. This highlights the difficulty of attempting to reduce the risk of tick-borne disease through host-targeted interventions alone. (C) 2015 Elsevier GmbH. All rights reserved. C1 [Harmon, Jessica R.; Jones, Carl J.] Univ Tennessee, Inst Agr, Entomol & Plant Pathol Dept, Knoxville, TN 37996 USA. [Harmon, Jessica R.; Scott, M. Cathy; Baker, Ellen M.; Hickling, Graham J.] Univ Tennessee, Inst Agr, Ctr Wildlife Hlth, Knoxville, TN 37996 USA. RP Harmon, JR (reprint author), Ctr Dis Control & Prevent, MS G14,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM jharmon4@gmail.com FU University of Tennessee Agricultural Experiment Station [TEN00423] FX We thank the managers at the retirement community and at HHSP for access to the study areas. At UTK we thank Dr. Reid Gerhardt and Dr. Marcy Souza for advice on the project, Michelle Rosen for the ticks collected in 2008, and David Paulson for field assistance and tick identification. Dr. Michael Yabsley (UGA) and Dr. Marina Eremeva (CDC) provided positive controls and helpful advice. This project was funded by the University of Tennessee Agricultural Experiment Station (NIFA Project No. TEN00423). NR 38 TC 4 Z9 4 U1 1 U2 10 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2015 VL 6 IS 3 BP 246 EP 252 DI 10.1016/j.ttbdis.2015.01.004 PG 7 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA CH6PI UT WOS:000354158100008 PM 25682494 ER PT J AU Paddock, CD Denison, AM Dryden, MW Noden, BH Lash, RR Abdelghani, SS Evans, AE Kelly, AR Hecht, JA Karpathy, SE Ganta, RR Little, SE AF Paddock, Christopher D. Denison, Amy M. Dryden, Michael W. Noden, Bruce H. Lash, R. Ryan Abdelghani, Sarah S. Evans, Anna E. Kelly, Aubree R. Hecht, Joy A. Karpathy, Sandor E. Ganta, Roman R. Little, Susan E. TI High prevalence of "Candidatus Rickettsia andeanae" and apparent exclusion of Rickettsia parkeri in adult Amblyomma maculatum (Acari: Ixodidae) from Kansas and Oklahoma SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE Amblyomma maculatum; Rickettsia parkeri; "Candidatus Rickettsia andeanae"; Rickettsial interference ID GULF-COAST TICKS; FEVER GROUP RICKETTSIA; LONE STAR TICK; POLYMERASE-CHAIN-REACTION; SPOTTED-FEVER; NORTH-CAROLINA; UNITED-STATES; EXPERIMENTAL-INFECTION; DERMACENTOR-ANDERSONI; VERTICAL TRANSMISSION AB Amblyomma maculatum (the Gulf Coast tick), an aggressive, human-biting, Nearctic and Neotropical tick, is the principal vector of Rickettsia parkeri in the United States. This pathogenic spotted fever group Rickettsia species has been identified in 8-52% of questing adult Gulf Coast ticks in the southeastern United States. To our knowledge, R. parkeri has not been reported previously from adult specimens of A. maculatum collected in Kansas or Oklahoma. A total of 216 adult A. maculatum ticks were collected from 18 counties in Kansas and Oklahoma during 2011-2014 and evaluated by molecular methods for evidence of infection with R. parkeri. No infections with this agent were identified; however, 47% of 94 ticks collected from Kansas and 73% of 122 ticks from Oklahoma were infected with "Candidatus Rickettsia andeanae" a spotted fever group Rickettsia species of undetermined pathogenicity. These preliminary data suggest that "Ca. R. andeanae" is well-adapted to survival in populations of A. maculatum in Kansas and Oklahoma, and that its ubiquity in Gulf Coast ticks in these states may effectively exclude R. parkeri from their shared arthropod host, which could diminish markedly or preclude entirely the occurrence of R. parkeri rickettsiosis in this region of the United States. Published by Elsevier GmbH. C1 [Paddock, Christopher D.; Hecht, Joy A.; Karpathy, Sandor E.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. [Denison, Amy M.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA 30333 USA. [Dryden, Michael W.; Ganta, Roman R.] Kansas State Univ, Dept Diagnost Med & Pathobiol, Manhattan, KS 66506 USA. [Noden, Bruce H.] Oklahoma State Univ, Dept Entomol & Plant Pathol, Stillwater, OK 74078 USA. [Lash, R. Ryan] Ctr Dis Control & Prevent, Travelers Hlth Branch, Atlanta, GA 30333 USA. [Abdelghani, Sarah S.] E Tennessee State Univ, Quillen Dishner Coll Med, Johnson City, TN 37614 USA. [Evans, Anna E.] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA. [Kelly, Aubree R.] Ctr Dis Control & Prevent, Bacterial Special Pathogens Branch, Atlanta, GA 30333 USA. [Little, Susan E.] Oklahoma State Univ, Vet Pathobiol, Stillwater, OK 74078 USA. RP Paddock, CD (reprint author), Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Mailstop G-13,1600 Clifton Rd, Atlanta, GA 30333 USA. EM CPaddock@cdc.gov FU Oklahoma Agricultural Experiment Station [OKL-02909] FX We thank Anne Barrett, Jeff Gruntmeir, Eileen Johnson, Jaclyn Martin, Anna Noden, Ethan Noden, and Donald Mock for assistance with the collection of ticks evaluated in this study. Financial support for BHN came from the Oklahoma Agricultural Experiment Station (OKL-02909). The findings and conclusions in this article are those of the authors and do not necessarily reflect the views of the U.S. Department of Health and Human Services. NR 55 TC 6 Z9 6 U1 0 U2 7 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2015 VL 6 IS 3 BP 297 EP 302 DI 10.1016/j.ttbdis.2015.02.001 PG 6 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA CH6PI UT WOS:000354158100015 PM 25773931 ER PT J AU Page, EH Couch, JR de Perio, MA AF Page, Elena H. Couch, James R. de Perio, Marie A. TI Evaluation of a Multiple Sclerosis Cluster Among Nurses in an Inpatient Oncology Ward SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article ID ENVIRONMENTAL RISK-FACTORS; ACROLEIN C1 [Page, Elena H.; Couch, James R.; de Perio, Marie A.] NIOSH, Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, Cincinnati, OH 45226 USA. RP Page, EH (reprint author), NIOSH, Ctr Dis Control & Prevent, US Dept Hlth & Human Serv, 4676 Columbia Pkwy,MS R 10, Cincinnati, OH 45226 USA. EM EPage@cdc.gov NR 18 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PY 2015 VL 12 IS 5 BP D54 EP D59 DI 10.1080/15459624.2014.989359 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA CG8UP UT WOS:000353590000002 PM 25835645 ER PT J AU Peterman, TA Furness, BW AF Peterman, Thomas A. Furness, Bruce W. TI Public health interventions to control syphilis SO SEXUAL HEALTH LA English DT Review DE effectiveness; evidence; incidence; prevalence; prevention; Treponema pallidum ID SEXUALLY-TRANSMITTED INFECTIONS; SOCIAL MARKETING CAMPAIGN; RANDOMIZED CONTROLLED-TRIAL; NEW-YORK-CITY; CASE-FINDING EFFECTIVENESS; PARTNER NOTIFICATION; UNITED-STATES; SEX WORKERS; ASYMPTOMATIC SYPHILIS; DISEASE-CONTROL AB Syphilis control strategies are old, but interventions have changed and there is now a more scientific approach to evidence of effectiveness. We searched PubMed using 'syphilis control' to identify papers that measured the effectiveness of interventions. We also included novel approaches and comprehensive responses to outbreaks. Few papers used high-quality research methodology and fewer evaluated impact on prevalence or incidence; most assessed intermediate outcomes. Syphilis can often be controlled by a combination of case finding, treatment and education. However, outbreaks are unique and ongoing evaluation is needed to see if interventions are producing intended intermediate outcomes at reasonable costs. C1 [Peterman, Thomas A.; Furness, Bruce W.] Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Furness, Bruce W.] HIV AIDS Hepatitis STD & TB Adm, Div STD TB Control, Washington, DC 20002 USA. RP Peterman, TA (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, Natl Ctr HIV Hepatitis STD & TB Prevent, Mailstop E02,1600 Clifton Rd, Atlanta, GA 30333 USA. EM tap1@cdc.gov NR 101 TC 1 Z9 1 U1 1 U2 5 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1448-5028 EI 1449-8987 J9 SEX HEALTH JI Sex Health PY 2015 VL 12 IS 2 SI SI BP 126 EP 134 DI 10.1071/SH14156 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CG4BX UT WOS:000353227300006 PM 25588031 ER PT J AU Harris, K Driban, JB Sitler, MR Cattano, NM Hootman, JM AF Harris, Kyle Driban, Jeffrey Bradford Sitler, Michael R. Cattano, Nicole M. Hootman, Jennifer M. TI Five-Year Clinical Outcomes of a Randomized Trial of Anterior Cruciate Ligament Treatment Strategies: An Evidence-Based Practice Paper SO JOURNAL OF ATHLETIC TRAINING LA English DT Article DE knee; anterior cruciate ligament reconstruction; osteoarthritis AB Reference/Citation: Frobell RB, Roos HP, Roos EM, Roemer FW, Ranstam J, Lohmander LS. Treatment for acute anterior cruciate ligament tear: five year outcome of randomised trial. BMJ. 2013;346:F232. Clinical Question: Does early anterior cruciate ligament (ACL) reconstruction with rehabilitation lead to better patientreported outcomes and a lower incidence of osteoarthritis at 5 years postinjury compared with delayed ACL reconstruction with rehabilitation? Study Selection: This randomized controlled trial with extended follow-up at 5 years postrandomization was conducted in 2 Swedish orthopaedic departments. Data Extraction: The authors studied a total of 121 moderately active adults (age = 18-35 years) with an acute ACL rupture in a knee with no other history of trauma. Excluded were patients with a collateral ligament rupture, full-thickness cartilage defect, or extensive meniscal fixation. One patient assigned to the early ACL-reconstruction group did not attend the 5-year follow-up visit. Patients were randomly assigned to (1) an early ACL reconstruction plus structured rehabilitation group (n = 62, surgery within 10 weeks of injury) or (2) optionaldelayed ACL reconstruction plus structured rehabilitation group (n = 59). The primary outcome measure was change in the average of 4 out of 5 subscales of the Knee Injury and Osteoarthritis Outcome Score (KOOS). The authors also assessed crude KOOS (combined 4 subscales), KOOS subscale scores, general physical and mental health (Short-Form 36), activity level (Tegner Activity Scale), mechanical knee stability (Lachman and pivot shift tests), meniscal surgery status, and presence of knee osteoarthritis on radiographs. Main Results: Among patients randomized to the optionaldelayed ACL-reconstruction group, 30 (51%) opted for an ACL reconstruction. The treatment groups had comparable 5-year patient-reported outcomes and changes in patient-reported outcomes (eg, knee pain, knee symptoms, activities of daily living, sport and recreational levels, knee-related quality of life, general physical health, and general mental health). Patients in the optional-delayed ACL-reconstruction group had greater mechanical knee instability than patients who received early ACL reconstruction; however, this was primarily among the patients opting for conservative management alone. In the overall sample, 61 knees (51%) required meniscal surgery over 5 years, regardless of treatment group. At 5 years, radiographs were available for 113 patients (93%). Overall, 29 patients (26%) had knee osteoarthritis at 5 years. Specifically, 13 patients (12%) developed tibiofemoral radiographic osteoarthritis (9 patients [16%] in the early ACL-reconstruction group, 4 [7%] in the optional-delayed ACL-reconstruction group) and 22 (19%) developed patellofemoral osteoarthritis (14 patients [24%] in the early ACL-reconstruction group, 8 [15%] in the optional-delayed ACL-reconstruction group). Patients with patellar tendon grafts (n = 40) had a greater incidence of ipsilateral patellofemoral osteoarthritis than patients with hamstrings tendon grafts (n = 51), but the 2 groups had similar incidences of ipsilateral tibiofemoral osteoarthritis. Six knees (5%) had both tibiofemoral and patellofemoral osteoarthritis. Conclusions: Early ACL reconstruction plus rehabilitation did not provide better results at 5 years compared with optionaldelayed ACL reconstruction plus rehabilitation. Furthermore, the authors found no radiographic differences among patients with early ACL reconstruction, delayed ACL reconstruction, or no ACL reconstruction (rehabilitation alone). C1 [Harris, Kyle] Bucks Cty Community Coll, Dept Hlth Phys Educ & Nursing, Newtown, PA 18940 USA. [Driban, Jeffrey Bradford] Tufts Med Ctr, Div Rheumatol, Boston, MA USA. [Sitler, Michael R.] Temple Univ, Dept Kinesiol, Athlet Training Div, Biokinet Res Lab, Philadelphia, PA 19122 USA. [Cattano, Nicole M.] W Chester Univ, Dept Sports Med, W Chester, PA USA. [Hootman, Jennifer M.] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Harris, K (reprint author), Bucks Cty Community Coll, Dept Hlth Phys Educ & Nursing, 275 Swamp Rd, Newtown, PA 18940 USA. EM kpfh85@gmail.com NR 5 TC 1 Z9 1 U1 1 U2 14 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA SN 1062-6050 EI 1938-162X J9 J ATHL TRAINING JI J. Athl. Train. PD JAN PY 2015 VL 50 IS 1 BP 110 EP 112 DI 10.4085/1062-6050-49.3.53 PG 3 WC Sport Sciences SC Sport Sciences GA CF0YJ UT WOS:000352270300015 PM 25322347 ER PT J AU Fox, JB Shaw, FE AF Fox, Jared B. Shaw, Frederic E. TI Clinical Preventive Services Coverage and the Affordable Care Act SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article AB The Affordable Care Act requires many health plans to provide coverage for certain recommended clinical preventive services without charging copays or deductible payments. This provision could lead to greater uptake of many services that can improve health and save lives. Although the coverage provision is broad, there are many caveats that also apply. It is important for providers and public health professionals to understand the nuances of the coverage rules to help maximize their potential to improve population health. C1 [Fox, Jared B.; Shaw, Frederic E.] Ctr Dis Control & Prevent, Off Associate Director Policy, Atlanta, GA USA. RP Fox, JB (reprint author), 1600 Clifton Rd NE,MS D-28, Atlanta, GA 30329 USA. EM jaredfox@cdc.gov FU Intramural CDC HHS [CC999999] NR 15 TC 15 Z9 15 U1 1 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JAN PY 2015 VL 105 IS 1 BP E7 EP E10 DI 10.2105/AJPH.2014.302289 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE6BG UT WOS:000351920100008 PM 25393173 ER PT J AU Spengler, JR Bente, DA AF Spengler, Jessica R. Bente, Dennis A. TI Therapeutic intervention in Crimean-Congo hemorrhagic fever: where are we now? SO FUTURE VIROLOGY LA English DT Editorial Material DE antiviral; Bunyavirus; Crimean-Congo hemorrhagic fever; therapeutics; treatment ID IMMUNE-RESPONSE; MOUSE MODEL; VIRUS; PATHOGENESIS; EPIDEMIOLOGY C1 [Spengler, Jessica R.] CDC, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30329 USA. [Bente, Dennis A.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA. [Bente, Dennis A.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. RP Bente, DA (reprint author), Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA. EM dabente@utmb.edu OI Spengler, Jessica R./0000-0002-5383-0513 FU Intramural CDC HHS [CC999999] NR 15 TC 2 Z9 3 U1 0 U2 2 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 1746-0794 EI 1746-0808 J9 FUTURE VIROL JI Future Virol. PY 2015 VL 10 IS 3 BP 203 EP 206 DI 10.2217/FVL.14.115 PG 4 WC Virology SC Virology GA CE2FU UT WOS:000351630600001 PM 26379760 ER PT J AU Saraiya, M Unger, E Steinau, M Thompson, T Hernandez, B Goodman, M AF Saraiya, Mona Unger, Elizabeth Steinau, Martin Thompson, Trevor Hernandez, Brenda Goodman, Marc TI Nationwide assessment of HPV types in cancers, including anal cancer, in the U.S: implications for current HPV 16/18 and new 9-valent vaccines SO SEXUAL HEALTH LA English DT Meeting Abstract C1 [Saraiya, Mona; Unger, Elizabeth; Steinau, Martin; Thompson, Trevor] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hernandez, Brenda] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA. [Goodman, Marc] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Canc Prevent & Control Program, Los Angeles, CA 90048 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU CSIRO PUBLISHING PI CLAYTON PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC 3168, AUSTRALIA SN 1448-5028 EI 1449-8987 J9 SEX HEALTH JI Sex Health PY 2015 VL 12 IS 1 MA 27 BP 89 EP 89 PG 1 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CE2AZ UT WOS:000351616200041 ER PT J AU Ashley, K AF Ashley, K. TI NIOSH Manual of Analytical Methods 5th Edition and harmonization of occupational exposure monitoring SO GEFAHRSTOFFE REINHALTUNG DER LUFT LA English DT Article ID FILTER SAMPLES; WORKPLACE AIR; PERFORMANCE; CAPSULES AB The NIOSH Manual of Analytical Methods (NMAM) is a collection of methods for sampling and analysis of contaminants in work-place air (or surfaces) and in the blood and urine of workers who are occupationally exposed. NIOSH methods are used worldwide for occupational exposure assessment. They have been developed or adapted by NIOSH and/or its partners and have been evaluated according to established protocols and performance criteria. NMAM also includes chapters on quality assurance, sampling guidance, instrumentation, aerosol measurement, gas and vapor monitoring, portable monitoring devices, and so forth. Often NIOSH methods are developed in coordination with voluntary consensus standards organizations. Efforts to harmonize NIOSH methods with relevant consensus standards procedures are highlighted. NIOSH also has a formal Memorandum of Understanding (MOU) with the Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA), whereby both are adopting selected methods. An overview of recent research and technology transfer activities relating to NMAM methods is provided. Included are newly approved methods and those under development, as well as needs for new methods and updates. Of particular interest are recent NIOSH recommendations on air samplers used for sampling and analysis of airborne particles. C1 US Dept HHS, NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45229 USA. RP Ashley, K (reprint author), US Dept HHS, NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45229 USA. NR 42 TC 1 Z9 1 U1 0 U2 2 PU SPRINGER-V D I VERLAG GMBH & CO KG PI DUSSELDORF PA VDI-PLATZ 1, D-40468 DUSSELDORF, GERMANY SN 0949-8036 EI 1436-4891 J9 GEFAHRST REINHALT L JI Gefahrst. Reinhalt. Luft PD JAN-FEB PY 2015 VL 75 IS 1-2 BP 7 EP 16 PG 10 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA CE0IZ UT WOS:000351489000002 ER PT J AU Kim, JH Roberge, RJ Powell, JB Shaffer, RE Ylitalo, CM Sebastian, JM AF Kim, Jung-Hyun Roberge, Raymond J. Powell, Jeffrey B. Shaffer, Ronald E. Ylitalo, Caroline M. Sebastian, John M. TI PRESSURE DROP OF FILTERING FACEPIECE RESPIRATORS: HOW LOW SHOULD WE GO? SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH LA English DT Article DE Respirator; Filter; Oral breathing; Nasal breathing ID HEALTH-CARE WORKERS; SIMULATED WORK; LOAD DETECTION; FLOW; RESISTANCE; PERCEPTION; EXERCISE; HUMANS; OBSTRUCTION; RESPONSES AB Objectives: This study was undertaken to determine the mean peak filter resistance to airflow (R-filter) encountered by subjects while wearing prototype filtering facepiece respirators (PRs) with low R-filter during nasal and oral breathing at sedentary and low-moderate work rates. Material and Methods: In-line pressure transducer measurements of mean R-filter across PRs with nominal R-filter of 29.4 Pa, 58.8 Pa and 88.2 Pa (measured at 85 l/min constant airflow) were obtained during nasal and oral breathing at sedentary and low-moderate work rates for 10 subjects. Results: The mean R-filter for the 29.4 PR was significantly lower than the other 2 PRs (p < 0.000), but there were no significant differences in mean R-filter between the PRs with 58.8 and 88.2 Pa filter resistance (p > 0.05). The mean R-filter was greater for oral versus nasal breathing and for exercise compared to sedentary activity (p < 0.001). Conclusions: Mean oral and nasal R-filter for all 3 PRs was at, or below, the minimal threshold level for detection of inspiratory resistance (the 58.8-74.5 Pa/lxs(-1)), which may account for the previously-reported lack of significant subjective or physiological differences when wearing PRs with these low R-filter Lowering filtering facepiece respirator R-filter below 88.2 Pa (measured at 85 l/min constant airflow) may not result in additional subjective or physiological benefit to the wearer. C1 [Kim, Jung-Hyun; Roberge, Raymond J.; Powell, Jeffrey B.; Shaffer, Ronald E.] NIOSH, Ctr Dis Control & Prevent, Natl Personal Protect Technol Lab, Technol Res Branch, Pittsburgh, PA 15236 USA. [Ylitalo, Caroline M.; Sebastian, John M.] 3M Co, Personal Safety Div 3M, St Paul, MN USA. RP Roberge, RJ (reprint author), NIOSH, Natl Personal Protect Technol Lab, CDC, Technol Res Branch, 626 Cochrans Mill Rd, Pittsburgh, PA 15236 USA. EM dtn0@cdc.gov FU National Institute for Occupational Safety and Health (NIOSH), part of the U.S. Centers for Disease Control and Prevention FX This work was supported by internal operating funds of the National Institute for Occupational Safety and Health (NIOSH), part of the U.S. Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the National Institute for Occupational Safety and Health. Mention of any product name does not imply endorsement. NR 40 TC 5 Z9 5 U1 1 U2 3 PU WALTER DE GRUYTER GMBH PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 1232-1087 EI 1896-494X J9 INT J OCCUP MED ENV JI Int. J. Occup. Med. Environ. Health PY 2015 VL 28 IS 1 BP 71 EP 80 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CE0JZ UT WOS:000351491600010 PM 26159949 ER PT J AU Kwon, SC Song, J Kim, YK Calvert, GM AF Kwon, Soon-Chan Song, Jaechul Kim, Yong-kyu Calvert, Geoffrey M. TI Work-Related Asthma in Korea - Findings from the Korea Work-Related Asthma Surveillance (KOWAS) program, 2004-2009 SO ALLERGY ASTHMA & IMMUNOLOGY RESEARCH LA English DT Article DE Work-related asthma; incidence; surveillance; industry; occupation ID OCCUPATIONAL RESPIRATORY-DISEASES; CAPTURE-RECAPTURE METHODS; NEW-ONSET ASTHMA; RISK-FACTORS; PREVALENCE; INDUSTRY; TRENDS; WORKPLACE; EXPOSURE; FRANCE AB Purpose: To determine the incidence and epidemiological characteristics of work-related asthma in Korea. Methods: During 2004-2009, the Korea Work-Related Asthma Surveillance (KOWAS) program collected data on new cases of work-related asthma from occupational physicians, allergy and chest physicians, regional surveillance systems, and workers' compensation schemes. The incidence was calculated on the basis of industry, occupation, sex, age, and region. In addition, the distribution of causal agents was determined. Results: During the study period, 236 cases of work-related asthma were reported, with 77 cases from more than 1 source. A total of 22.0% (n=52) were reported by occupational physicians, 52.5% (n=124) by allergy and chest physicians, 24.2% (n=57) by regional surveillance systems, and 43.2% (n=102) by workers' compensation schemes. The overall average annual incidence was 3.31 cases/million workers, with a rate of 3.78/million among men and 2.58/million among women. The highest incidence was observed in the 50-59-year age group (7.74/million), in the Gyeonggi/Incheon suburb of Seoul (8.50/million), in the furniture and other instrument manufacturing industries (67.62/million), and among craft and related trades workers (17.75/million). The most common causal agents were isocyanates (46.6%), flour/grain (8.5%), metal (5.9%), reactive dyes (5.1%), and solvents (4.2%). Conclusions: The incidence of work-related asthma in Korea was relatively low, and varied according to industry, occupation, gender, age, and region. Data provided by workers' compensation schemes and physician reports have been useful for determining the incidence and causes of work-related asthma. C1 [Kwon, Soon-Chan; Song, Jaechul] Hanyang Univ, Dept Occupat & Environm Med, Seoul 133791, South Korea. [Kim, Yong-kyu] Daejeon Sun Hosp, Ctr Occupat & Environm Med, Taejon, South Korea. [Calvert, Geoffrey M.] NIOSH, Cincinnati, OH 45226 USA. RP Song, J (reprint author), Hanyang Univ, Coll Med, Dept Occupat & Environm Med, 222 Wangsimni Ro, Seoul 133791, South Korea. EM jsong@hanyang.ac.kr NR 47 TC 5 Z9 5 U1 1 U2 2 PU KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY PI JONGNO-GU PA RM 1705, KUMHO BLDG 327-2, CHANGSINDONG, JONGNO-GU, SEOUL 110-540, SOUTH KOREA SN 2092-7355 EI 2092-7363 J9 ALLERGY ASTHMA IMMUN JI Allergy Asthma Immunol. Res. PD JAN PY 2015 VL 7 IS 1 BP 51 EP 59 DI 10.4168/aair.2015.7.1.51 PG 9 WC Allergy; Immunology SC Allergy; Immunology GA CD1KE UT WOS:000350833000008 PM 25553263 ER PT J AU Alvarenga, KDF Morata, TC Lopes, AC Feniman, MR Corteletti, LCBJ AF Alvarenga, Katia de Freitas Morata, Thais Catalani Lopes, Andrea Cintra Feniman, Mariza Ribeiro Bornia Jacob Corteletti, Lilian Cassia TI Brainstem auditory evoked potentials in children with lead exposure SO BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY LA English DT Article DE Toxicity; Lead poisoning; Brainstem auditory evoked potentials; Pure-tone audiometry ID CENTRAL-NERVOUS-SYSTEM; BLOOD LEAD; HEARING THRESHOLDS; WORKERS; CONDUCTION AB Introduction: Earlier studies have demonstrated an auditory effect of lead exposure in children, but information on the effects of low chronic exposures needs to be further elucidated. Objective: To investigate the effect of low chronic exposures of the auditory system in children with a history of low blood lead levels, using an auditory electrophysiological test. Methods: Contemporary cross-sectional cohort. Study participants underwent tympanometry, pure tone and speech audiometry, transient evoked otoacoustic emissions, and brainstem auditory evoked potentials, with blood lead monitoring over a period of 35.5 months. The study included 130 children, with ages ranging from 18 months to 14 years, 5 months (mean age 6 years, 8 months +/- 3 years, 2 months). Results: The mean time-integrated cumulative blood lead index was 12 mu g/dL (SD +/- 5.7, range: 2.433). All participants had hearing thresholds equal to or below 20 dBHL and normal amplitudes of transient evoked otoacoustic emissions. No association was found between the absolute latencies of waves I, III, and V, the interpeak latencies I-III, III-V, and I-V, and the cumulative lead values. Conclusion: No evidence of toxic effects from chronic low lead exposures was observed on the auditory function of children living in a lead contaminated area. (C) 2014 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda. All rights reserved. C1 [Alvarenga, Katia de Freitas; Lopes, Andrea Cintra; Feniman, Mariza Ribeiro; Bornia Jacob Corteletti, Lilian Cassia] Univ Sao Paulo, FOB, Dept Speech Therapy & Audiol, Bauru, SP, Brazil. [Morata, Thais Catalani] NIOSH, Div Appl Res & Technol, Cincinnati, OH 45226 USA. RP Corteletti, LCBJ (reprint author), Univ Sao Paulo, FOB, Dept Speech Therapy & Audiol, Bauru, SP, Brazil. EM lilianjacob@fob.usp.br RI Lopes, Andrea/D-3179-2012; Jacob-Corteletti , Lilian Cassia /I-9391-2012; Feniman, Mariza /I-6596-2012; Alvarenga, Katia/D-3235-2012 NR 34 TC 1 Z9 1 U1 0 U2 8 PU ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL PI SAO PAULO PA AV INDIANOPOLOS 740, MOEMA, SAO PAULO, SP 04062-001, BRAZIL SN 1808-8694 EI 1808-8686 J9 BRAZ J OTORHINOLAR JI Braz. J. Otorhinolaryngol. PD JAN-FEB PY 2015 VL 81 IS 1 BP 37 EP 43 DI 10.1016/j.bjorl.2013.12.001 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA CC3SJ UT WOS:000350269400008 ER PT J AU Pappas, RS Fresquez, MR Watson, CH AF Pappas, R. Steven Fresquez, Mark R. Watson, Clifford H. TI Cigarette Smoke Cadmium Breakthrough From Traditional Filters: Implications for Exposure SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID MAINSTREAM SMOKE; PARTICULATE MATTER; MASS-SPECTROMETRY; LUNG; LEAD; URINE; BLOOD; POPULATION; PARTICLES; EMPHYSEMA AB Cadmium, a carcinogenic metal, is highly toxic to renal, skeletal, nervous, respiratory and cardiovascular systems. Accurate and precise quantification of mainstream smoke cadmium levels in cigarette smoke is important because of exposure concerns. The two most common trapping techniques for collecting mainstream tobacco smoke particulate for analysis are glass fiber filters and electrostatic precipitators. We observed that a significant portion of total cadmium passed through standard glass fiber filters that are used to trap particulate matter. We therefore developed platinum traps to collect the cadmium that passed through the filters and tested a variety of cigarettes with different physical parameters for quantities of cadmium that passed though the filters. We found <1% cadmium passed through electrostatic precipitators. In contrast, cadmium that passed through 92 mm glass fiber filters on a rotary smoking machine was significantly higher, ranging from 3.5 to 22.9% of total smoke cadmium deliveries. Cadmium passed through 44 mm filters typically used on linear smoking machines to an even greater degree, ranging from 13.6 to 30.4% of the total smoke cadmium deliveries. Differences in the cadmium that passed through from the glass fiber filters and electrostatic precipitator could be explained in part if cadmium resides in the smaller mainstream smoke aerosol particle sizes. Differences in particle size distribution could have toxicological implications and could help explain the pulmonary and cardiovascular cadmium uptake in smokers. C1 [Pappas, R. Steven; Watson, Clifford H.] Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, Atlanta, GA 30341 USA. [Fresquez, Mark R.] Battelle Analyt Serv, Atlanta, GA USA. RP Pappas, RS (reprint author), Ctr Dis Control & Prevent, Tobacco & Volatiles Branch, 4770 Buford Highway,MS F-44, Atlanta, GA 30341 USA. EM rpappas@cdc.gov FU U.S. Food and Drug Administration Center for Tobacco Products FX This study was funded through an interagency agreement by the U.S. Food and Drug Administration Center for Tobacco Products. NR 45 TC 3 Z9 3 U1 2 U2 14 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0146-4760 EI 1945-2403 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD JAN-FEB PY 2015 VL 39 IS 1 BP 45 EP 51 DI 10.1093/jat/bku115 PG 7 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA CC3BD UT WOS:000350218200008 PM 25313385 ER PT J AU Yucesoy, B Charles, LE Baker, B Burchfiel, CM AF Yucesoy, Berran Charles, Luenda E. Baker, Brent Burchfiel, Cecil M. TI Occupational and genetic risk factors for osteoarthritis: A review SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Review DE Joint disorders; joint pain; workers; occupation; genetics ID NUTRITION EXAMINATION SURVEY; ESTROGEN-RECEPTOR-ALPHA; RADIOGRAPHIC KNEE OSTEOARTHRITIS; ACID REPEAT POLYMORPHISM; VITAMIN-D-RECEPTOR; HIP OSTEOARTHRITIS; HAND OSTEOARTHRITIS; UNITED-STATES; SUSCEPTIBILITY LOCUS; NATIONAL-HEALTH AB BACKGROUND: Osteoarthritis (OA) is a multifactorial disease with strong genetic and occupational components. Although published studies have described several risk factors for OA, very few studies have investigated the occupational and genetic factors that contribute to this debilitating condition. OBJECTIVE: To describe occupational and genetic factors that may contribute to the risk of developing (OA). METHODS: A literature search was conducted in PubMed using the search terms osteoarthritis, occupation, work, and genetics. RESULTS: Heavy physical work load was the most common occupational risk factor for OA in several anatomical locations. Other factors include kneeling and regular stair climbing, crawling, bending and whole body vibration, and repetitive movements. Numerous studies have also shown the influence of genetic variability in the pathogenesis of OA. Genetic variants of several groups of genes e.g., cartilage extracellular matrix structural genes and the genes related to bone density have been implicated in disease pathogenesis. CONCLUSION: This review shows that occupational factors were extensively studied in knee OA unlike OA of other anatomical regions. Although genetic association studies performed to date identified a number of risk variants, some of these associations have not been consistently replicated across different studies and populations. Therefore, more research is needed. C1 [Yucesoy, Berran; Baker, Brent] NIOSH, Toxicol & Mol Biol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Charles, Luenda E.; Burchfiel, Cecil M.] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. RP Yucesoy, B (reprint author), NIOSH, CDC, Hlth Effects Lab Div, Toxicol & Mol Biol Branch, 1095 Willowdale Rd,M-S 3014, Morgantown, WV 26505 USA. EM yab7@cdc.gov FU Intramural CDC HHS [CC999999] NR 121 TC 4 Z9 4 U1 2 U2 17 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 EI 1875-9270 J9 WORK JI Work PY 2015 VL 50 IS 2 BP 261 EP 273 DI 10.3233/WOR-131739 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC7UW UT WOS:000350574900011 PM 24004806 ER PT J AU Eastlake, AC Knipper, BS He, XJ Alexander, BM Davis, KG AF Eastlake, Adrienne C. Knipper, Brad S. He, Xinjian Alexander, Barbara M. Davis, Kermit G. TI Lifestyle and safety practices of firefighters and their relation to cardiovascular risk factors SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Article DE Cardiovascular disease; firefighters; exposure; body mass index; high cholesterol ID CORONARY-HEART-DISEASE; YORK-CITY FIREFIGHTERS; LONG-TERM EXPOSURE; CARDIORESPIRATORY FITNESS; MYOCARDIAL-INFARCTION; AIR-POLLUTION; UNITED-STATES; WHOLE GRAINS; MORTALITY; STRESS AB BACKGROUND: In the United States, over 50% of the deaths of on-duty firefighters are classified as sudden cardiac deaths. A holistic view of the multiple risk factors and their relation to the prevalence of cardiovascular disease (CVD) is necessary to determine a baseline for prevention. METHODS: This study surveyed 154 firefighters in a large Midwestern county about their individual exposure to particulates, noise, heat stress, skin contamination, and physical stress; lifestyle factors such as exercise, diet, smoking, and alcohol consumption; health status; and demographic factors. RESULTS: Consumption of whole grains and alcohol were associated with a reduction of the risk of heart disease, while higher Body Mass Index (BMI) scores and increasing age were associated with increased risk of heart disease. CONCLUSIONS: Although firefighters are exposed to substantial occupational risks, only lifestyle factors were found to significantly predict CVD and related health issues. BMI is a modifiable risk factor, which, if controlled, could appreciably improve health outcomes. C1 [Eastlake, Adrienne C.; Knipper, Brad S.; He, Xinjian; Alexander, Barbara M.; Davis, Kermit G.] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH USA. RP Alexander, BM (reprint author), NIOSH, Ctr Dis Control, US Dept HHS, 5555 Ridge Ave, Cincinnati, OH 45213 USA. EM BAlexander@cdc.gov OI Alexander, Barbara/0000-0003-1742-403X FU National Institute for Occupational Safety and Health through University of Cincinnati Education and Research Center [T42/OH008432-06] FX This research was partially supported by the National Institute for Occupational Safety and Health through the University of Cincinnati Education and Research Center. Grant number: T42/OH008432-06. NR 44 TC 1 Z9 1 U1 0 U2 7 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 EI 1875-9270 J9 WORK JI Work PY 2015 VL 50 IS 2 BP 285 EP 294 DI 10.3233/WOR-131796 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CC7UW UT WOS:000350574900013 PM 24284685 ER PT J AU Ssemwanga, D Lihana, RW Ugoji, C Abimiku, A Nkengasong, J Dakum, P Ndembi, N AF Ssemwanga, Deogratius Lihana, Raphael W. Ugoji, Chinenye Abimiku, Alash'le Nkengasong, John Dakum, Patrick Ndembi, Nicaise TI Update on HIV-1 Acquired and Transmitted Drug Resistance in Africa SO AIDS REVIEWS LA English DT Review DE Acquired drug resistance; Africa; Antiretroviral therapy; HIV-1; Drug resistance; Transmitted drug resistance ID IMMUNODEFICIENCY-VIRUS TYPE-1; ACTIVE ANTIRETROVIRAL THERAPY; TREATMENT-NAIVE PATIENTS; REVERSE-TRANSCRIPTASE MUTATIONS; NORTHEASTERN SOUTH-AFRICA; UNIQUE RECOMBINANT FORMS; NEWLY-DIAGNOSED PATIENTS; SINGLE-DOSE NEVIRAPINE; SUB-SAHARAN AFRICA; POL GENE DIVERSITY AB The last ten years have witnessed a significant scale-up and access to antiretroviral therapy in Africa, which has improved patient quality of life and survival. One major challenge associated with increased access to antiretroviral therapy is the development of antiretroviral resistance due to inconsistent drug supply and/or poor patient adherence. We review the current state of both acquired and transmitted drug resistance in Africa over the past ten years (2001-2011) to identify drug resistance associated with the different drug regimens used on the continent and to help guide affordable strategies for drug resistance surveillance. A total of 161 references (153 articles, six reports and two conference abstracts) were reviewed. Antiretroviral resistance data was available for 40 of 53 African countries. A total of 5,541 adult patients from 99 studies in Africa were included in this analysis. The pooled prevalence of drug resistance mutations in Africa was 10.6%, and Central Africa had the highest prevalence of 54.9%. The highest prevalence of nucleoside reverse transcriptase inhibitor mutations was in the west (55.3%) and central (54.8%) areas; nonnucleoside reverse transcriptase inhibitor mutations were highest in East Africa (57.0%) and protease inhibitors mutations highest in Southern Africa (16.3%). The major nucleoside reverse transcriptase inhibitor mutation in all four African regions was M184V Major nonnucleoside reverse transcriptase inhibitor as well as protease inhibitor mutations varied by region. The prevalence of drug resistance has remained low in several African countries although the emergence of drug resistance mutations varied across countries. Continued surveillance of antiretroviral therapy resistance remains crucial in gauging the effectiveness of country antiretroviral therapy programs and strategizing on effective and affordable strategies for successful treatment. C1 [Ssemwanga, Deogratius] MRC UVRI Uganda Res Unit AIDS, Entebbe, Uganda. [Lihana, Raphael W.] Kenya Med Res Inst KEMRI, Ctr Virol Res, Nairobi, Kenya. [Nkengasong, John] US Ctr Dis Control & Prevent, Div Global HIV AIDS, Int Lab Branch, Atlanta, GA USA. [Ugoji, Chinenye; Abimiku, Alash'le; Dakum, Patrick; Ndembi, Nicaise] Inst Human Virol IHV Nigeria, Abuja, Nigeria. [Abimiku, Alash'le] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. RP Ndembi, N (reprint author), Maine Court, Inst Human Virol Nigeria, Pent House,Plot 252,Herbert Macaulay Way, Abuja, Nigeria. EM ndembinic@yahoo.fr NR 161 TC 12 Z9 12 U1 0 U2 7 PU PERMANYER PUBL PI BARCELONA PA MALLORCA, 310, BARCELONA, 08037, SPAIN SN 1139-6121 EI 1698-6997 J9 AIDS REV JI Aids Rev. PD JAN-MAR PY 2015 VL 17 IS 1 BP 3 EP 20 PG 18 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CB8JS UT WOS:000349876400001 PM 25427100 ER PT J AU Goddard, J Embers, M Hojgaard, A Piesman, J AF Goddard, Jerome Embers, Monica Hojgaard, Andrias Piesman, Joseph TI Comparison of Tick Feeding Success and Vector Competence for Borrelia burgdorferi Among Immature Ixodes scapularis (Ixodida: Ixodidae) of Both Southern and Northern Clades SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Ixodes scapularis; Immatures; Lyme disease; Feeding success; Vector competence ID LYME-DISEASE SPIROCHETE; GULF-COAST TICK; FEVER-GROUP RICKETTSIAE; AMERICAN DOG TICK; DERMACENTOR-VARIABILIS; BLACKLEGGED TICK; ANAPLASMA-PHAGOCYTOPHILUM; AMBLYOMMA-AMERICANUM; ACARI IXODIDAE; SMALL MAMMALS AB Northern and southern Ixodes scapularis Say populations differ greatly in density, host utilization, and especially questing behavior of the immatures. Haplotypes of I. scapularis in North America can be divided into two major clades-the All American Clade (haplotypes A through J) and the Southern Clade (M through O). This genetic variation may affect feeding success and vector competence. This study compared feeding success of larval I. scapularis measured by time-to-drop-off and subsequent transmissibility success of Borrelia burgdorferi to mice using ticks from Mississippi, Connecticut (both F haplotype), and Louisiana (haplotype O). Northern ticks (CT) fed to repletion much faster than MS and LA ticks: overall, 73.6% of CT ticks had dropped off mice at Day 3 compared to only 1.7% and 6.6% of ticks dropped off for MS and LA ticks at that same time point. As for vector competence, 4 of the 4 mice in each case (MS or CT) that had been fed on by infected nymphs tested positive for Borrelia burgdorferi. In a second experiment, 5 of the 6 mice tested positive for Borrelia burgdorferi after exposure to infected LA ticks as compared with 3 of the 4 mice exposed to infected CT ticks. These data demonstrate that there is no difference in northern and southern populations of I. scapularis in their ability to transmit Borrelia burgdorferi, but the ability of the northern populations to feed rapidly on rodents exceeds that of southern populations. C1 [Goddard, Jerome] Mississippi State Univ, Dept Biochem Mol Biol Entomol & Plant Pathol, Mississippi State, MS 39762 USA. [Embers, Monica] Tulane Natl Primate Res Ctr, Div Bacteriol & Parasitol, Covington, LA USA. [Hojgaard, Andrias; Piesman, Joseph] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. RP Goddard, J (reprint author), Mississippi State Univ, Dept Biochem Mol Biol Entomol & Plant Pathol, 100 Twelve Lane,Clay Lyle Entomol Bldg, Mississippi State, MS 39762 USA. EM jgoddard@entomology.msstate.edu FU NCRR NIH HHS [P51 RR000164]; NIH HHS [P51 OD011104] NR 31 TC 7 Z9 7 U1 3 U2 20 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 2015 VL 52 IS 1 BP 81 EP 85 DI 10.1093/jme/tju005 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA CC0KF UT WOS:000350023600011 PM 26336283 ER PT J AU Westercannp, N Arguin, PM AF Westercannp, Nelli Arguin, Paul M. TI Malaria chennoprophylaxis: A proven public health intervention for international travelers SO TRAVEL MEDICINE AND INFECTIOUS DISEASE LA English DT Editorial Material C1 [Westercannp, Nelli; Arguin, Paul M.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. [Westercannp, Nelli] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. RP Westercannp, N (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. EM Nwestercamp@cdc.gov FU Intramural CDC HHS [CC999999] NR 7 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1477-8939 EI 1873-0442 J9 TRAVEL MED INFECT DI JI Travel Med. Infect. Dis. PD JAN-FEB PY 2015 VL 13 IS 1 BP 8 EP 9 DI 10.1016/j.tmaid.2014.12.006 PG 2 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CC1GM UT WOS:000350089200004 PM 25593041 ER PT J AU Landman, KZ Tan, KR Arguin, PM AF Landman, Keren Z. Tan, Kathrine R. Arguin, Paul M. TI Adherence to malaria prophylaxis among Peace Corps Volunteers in the Africa region, 2013 SO TRAVEL MEDICINE AND INFECTIOUS DISEASE LA English DT Article DE Malaria prevention; Malaria in long-term travelers; Malaria chemoprophylaxis ID SUB-SAHARAN AFRICA; DOUBLE-BLIND; NONIMMUNE TRAVELERS; ATOVAQUONE-PROGUANIL; CHEMOPROPHYLAXIS; MEFLOQUINE; TOLERABILITY AB Background: Although malaria can be prevented with prophylaxis, it is diagnosed in over 100 Africa-region Peace Corps Volunteers annually. This suggests that prophylaxis non-adherence is a problem in these non-immune travelers. Methods: We investigated Volunteers' knowledge, attitudes, and practices regarding prophylaxis using an internet-based survey during August 19-September 30, 2013. Adherence was defined as taking doxycycline or atovaquone-proguanil daily, or taking mefloquine doses no more than 8 days apart. Results: The survey was sent to 3248 Volunteers. Of 781 whose responses were analyzed, 514 (73%) reported adherence to prophylaxis. The most common reasons for non-adherence were forgetting (n = 530, 90%); fear of long-term adverse effects (LTAEs; n = 316, 54%); and experiencing adverse events that Volunteers attributed to prophylaxis (n = 297, 51%). Two hundred fourteen (27%) Volunteers reported not worrying about malaria. On multivariate analysis controlling for sex and experiencing adverse events Volunteers attributed to prophylaxis, the factor most strongly associated with non-adherence was being prescribed mefloquine (OR 5.4, 95% confidence interval 3.2-9.0). Conclusions: We found moderate adherence and a prevailing fear of LTAEs among Volunteers. Strategies to improve prophylaxis adherence may include medication reminders, increasing education about prophylaxis safety and malaria risk, and promoting prompt management of prophylaxis side effects. Published by Elsevier Ltd. C1 [Landman, Keren Z.; Tan, Kathrine R.; Arguin, Paul M.] US Ctr Dis Control & Prevent, Ctr Global Hlth, Malaria Branch, Atlanta, GA 30333 USA. RP Tan, KR (reprint author), US Ctr Dis Control & Prevent, Ctr Global Hlth, Malaria Branch, 1600 Clifton Rd NE,MS A06, Atlanta, GA 30333 USA. EM klandman@gmail.com; ktan@cdc.gov; parguin@cdc.gov FU Intramural CDC HHS [CC999999] NR 16 TC 1 Z9 1 U1 2 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1477-8939 EI 1873-0442 J9 TRAVEL MED INFECT DI JI Travel Med. Infect. Dis. PD JAN-FEB PY 2015 VL 13 IS 1 BP 61 EP 68 DI 10.1016/j.tmaid.2014.12.001 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CC1GM UT WOS:000350089200009 PM 25534297 ER PT J AU Adam, JK Varan, AK Kao, AS McDonald, EC Waterman, SH AF Adam, Jessica K. Varan, Aiden K. Kao, Annie S. McDonald, Eric C. Waterman, Stephen H. TI Fatal influenza outbreak aboard a sport fishing vessel in San Diego, California SO TRAVEL MEDICINE AND INFECTIOUS DISEASE LA English DT Letter DE Influenza; Sport fishing; Outbreak C1 [Adam, Jessica K.; Varan, Aiden K.; Kao, Annie S.; McDonald, Eric C.] Cty San Diego Hlth & Human Serv Agcy, San Diego, CA USA. [Adam, Jessica K.; Waterman, Stephen H.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. RP Varan, AK (reprint author), 3851 Rosecrans St,Suite 715, San Diego, CA 92110 USA. EM vvl5@cdc.gov NR 3 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1477-8939 EI 1873-0442 J9 TRAVEL MED INFECT DI JI Travel Med. Infect. Dis. PD JAN-FEB PY 2015 VL 13 IS 1 BP 102 EP 103 DI 10.1016/j.tmaid.2014.12.002 PG 2 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CC1GM UT WOS:000350089200016 PM 25534296 ER PT J AU Chemaly, RF Dantes, R Shah, DP Shah, PK Pascoe, N Ariza-Heredia, E Perego, C Nguyen, DB Nguyen, K Modarai, F Moulton-Meissner, H Noble-Wang, J Tarrand, JJ LiPuma, JJ Guh, AY MacCannell, T Raad, I Mulanovich, V AF Chemaly, Roy F. Dantes, Raymund Shah, Dimpy P. Shah, Pankil K. Pascoe, Neil Ariza-Heredia, Ella Perego, Cheryl Nguyen, Duc B. Kim Nguyen Modarai, Farhad Moulton-Meissner, Heather Noble-Wang, Judith Tarrand, Jeffrey J. LiPuma, John J. Guh, Alice Y. MacCannell, Tara Raad, Issam Mulanovich, Victor TI Cluster and Sporadic Cases of Herbaspirillum Species Infections in Patients With Cancer SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE Herbaspirillum; cancer; outbreak; immunocompromised; misdiagnosis ID CYSTIC-FIBROSIS PATIENTS; PATHOGENIC BACTERIA; IDENTIFICATION; WATER; NOV AB Background. Herbaspirillum species are gram-negative Betaproteobacteria that inhabit the rhizosphere. We investigated a potential cluster of hospital-based Herbaspirillum species infections. Methods. Cases were defined as Herbaspirillum species isolated from a patient in our comprehensive cancer center between 1 January 2006 and 15 October 2013. Case finding was performed by reviewing isolates initially identified as Burkholderia cepacia susceptible to all antibiotics tested, and 16S ribosomal DNA sequencing of available isolates to confirm their identity. Pulsed-field gel electrophoresis (PFGE) was performed to test genetic relatedness. Facility observations, infection prevention assessments, and environmental sampling were performed to investigate potential sources of Herbaspirillum species. Results. Eight cases of Herbaspirillum species were identified. Isolates from the first 5 clustered cases were initially misidentified as B. cepacia, and available isolates from 4 of these cases were indistinguishable. The 3 subsequent cases were identified by prospective surveillance and had different PFGE patterns. All but 1 case-patient had bloodstream infections, and 6 presented with sepsis. Underlying diagnoses included solid tumors (3), leukemia (3), lymphoma (1), and aplastic anemia (1). Herbaspirillum species infections were hospital-onset in 5 patients and community-onset in 3. All symptomatic patients were treated with intravenous antibiotics, and their infections resolved. No environmental source or common mechanism of acquisition was identified. Conclusions. This is the first report of a hospital-based cluster of Herbaspirillum species infections. Herbaspirillum species are capable of causing bacteremia and sepsis in immunocompromised patients. Herbaspirillum species can be misidentified as Burkholderia cepacia by commercially available microbial identification systems. C1 [Chemaly, Roy F.; Shah, Dimpy P.; Ariza-Heredia, Ella; Perego, Cheryl; Kim Nguyen; Raad, Issam; Mulanovich, Victor] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA. [Dantes, Raymund; Nguyen, Duc B.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Sci Educ & Profess Dev Program Off, Atlanta, GA USA. [Dantes, Raymund; Nguyen, Duc B.; Modarai, Farhad; Moulton-Meissner, Heather; Noble-Wang, Judith; Guh, Alice Y.; MacCannell, Tara] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA. [Shah, Pankil K.] Univ Texas Houston, Sch Publ Hlth, Houston, TX USA. [Pascoe, Neil] Texas Dept State Hlth Serv, Austin, TX USA. [Tarrand, Jeffrey J.] Univ Texas MD Anderson Canc Ctr, Dept Lab Med, Houston, TX 77030 USA. [LiPuma, John J.] Univ Michigan, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA. RP Chemaly, RF (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Unit 402,1515 Holcombe Blvd, Houston, TX 77030 USA. EM rfchemaly@mdanderson.org FU National Institutes of Health through the MD Anderson Cancer Center [CA016672]; Cystic Fibrosis Foundation FX This research was supported in part by the National Institutes of Health through the MD Anderson Cancer Center (support grant CA016672). J. J. L. receives support from the Cystic Fibrosis Foundation. NR 14 TC 1 Z9 1 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 1 PY 2015 VL 60 IS 1 BP 48 EP 54 DI 10.1093/cid/ciu712 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CB5LJ UT WOS:000349668300010 PM 25216687 ER PT J AU Limbago, BM Pierce, VM Lonsway, DR Ferraro, MJ AF Limbago, Brandi M. Pierce, Virginia M. Lonsway, David R. Ferraro, Mary Jane TI Elevated Staphylococcus Ceftriaxone MICs are an Etest Artifact SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 [Limbago, Brandi M.; Lonsway, David R.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30329 USA. [Pierce, Virginia M.; Ferraro, Mary Jane] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Pierce, Virginia M.; Ferraro, Mary Jane] Harvard Univ, Sch Med, Boston, MA USA. RP Limbago, BM (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd,MS C-16, Atlanta, GA 30329 USA. EM BBL7@cdc.gov NR 5 TC 0 Z9 0 U1 1 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 1 PY 2015 VL 60 IS 1 BP 162 EP U4444 DI 10.1093/cid/ciu743 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CB5LJ UT WOS:000349668300029 PM 25266286 ER PT J AU Payne, DC Baggs, J Klein, NP Parashar, UD AF Payne, Daniel C. Baggs, James Klein, Nicola P. Parashar, Umesh D. TI Does Preventing Rotavirus Infections Through Vaccination Also Protect Against Naturally Occurring Intussusception Over Time? SO CLINICAL INFECTIOUS DISEASES LA English DT Letter ID US INFANTS; RISK; SAFETY C1 [Payne, Daniel C.; Baggs, James; Parashar, Umesh D.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Klein, Nicola P.] Kaiser Permanente, Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA. RP Payne, DC (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS-A34, Atlanta, GA 30333 USA. EM dvp6@cdc.gov FU Intramural CDC HHS [CC999999] NR 9 TC 3 Z9 3 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 1 PY 2015 VL 60 IS 1 BP 163 EP U215 DI 10.1093/cid/ciu746 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CB5LJ UT WOS:000349668300030 PM 25249522 ER PT J AU Litvintseva, AP Marsden-Haug, N Hurst, S Hill, H Gade, L Driebe, EM Ralston, C Roe, C Barker, BM Goldoft, M Keim, P Wohrle, R Thompson, GR Engelthaler, DM Brandt, ME Chiller, T AF Litvintseva, Anastasia P. Marsden-Haug, Nicola Hurst, Steven Hill, Heather Gade, Lalitha Driebe, Elizabeth M. Ralston, Cindy Roe, Chandler Barker, Bridget M. Goldoft, Marcia Keim, Paul Wohrle, Ron Thompson, George R., III Engelthaler, David M. Brandt, Mary E. Chiller, Tom TI Valley Fever: Finding New Places for an Old Disease: Coccidioides immitis Found in Washington State Soil Associated With Recent Human Infection SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE Coccidioides; valley fever; soil detection; WGS typing ID DESERT DUST; CLOUDS AB We used real-time polymerase chain reaction and culture to demonstrate persistent colonization of soils by Coccidioides immitis, an agent of valley fever, in Washington State linked to recent human infections and located outside the endemic range. Whole-genome sequencing confirmed genetic identity between isolates from soil and one of the case-patients. C1 [Litvintseva, Anastasia P.; Hurst, Steven; Gade, Lalitha; Brandt, Mary E.; Chiller, Tom] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA. [Marsden-Haug, Nicola; Goldoft, Marcia; Wohrle, Ron] Washington State Dept Hlth, Shoreline, WA USA. [Marsden-Haug, Nicola; Goldoft, Marcia; Wohrle, Ron] Washington State Dept Hlth, Tumwater, WA USA. [Hill, Heather; Ralston, Cindy] Benton Franklin Hlth Dist, Washington, DC USA. [Driebe, Elizabeth M.; Roe, Chandler; Barker, Bridget M.; Keim, Paul; Engelthaler, David M.] Translat Genom Res Inst, Flagstaff, AZ USA. [Thompson, George R., III] Univ Calif Davis, Coccidioidomycosis Serol Lab, Davis, CA 95616 USA. RP Litvintseva, AP (reprint author), Ctr Dis Control & Prevent, Mycot Dis Branch, 1600 Clifton Rd,MS G-11, Atlanta, GA 30333 USA. EM frq8@cdc.gov FU NIAID NIH HHS [K22 AI104801] NR 11 TC 22 Z9 22 U1 2 U2 17 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 1 PY 2015 VL 60 IS 1 BP E1 EP E3 DI 10.1093/cid/ciu681 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA CB5LJ UT WOS:000349668300001 PM 25165087 ER PT J AU Takarinda, KC Harries, AD Shiraishi, RW Mutasa-Apollo, T Abdul-Quader, A Mugurungi, O AF Takarinda, Kudakwashe C. Harries, Anthony D. Shiraishi, Ray W. Mutasa-Apollo, Tsitsi Abdul-Quader, Abu Mugurungi, Owen TI Gender-related differences in outcomes and attrition on antiretroviral treatment among an HIV-infected patient cohort in Zimbabwe: 2007-2010 SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE Antiretroviral therapy; Attrition; Zimbabwe; Gender differences; HIV mortality ID HUMAN-IMMUNODEFICIENCY-VIRUS; FOLLOW-UP; PATIENTS LOST; THERAPY; MORTALITY; ADULTS; MALAWI; PROGRAMS; CAMEROON; ANEMIA AB Objectives: To determine (1) gender-related differences in antiretroviral therapy (ART) outcomes, and (2) gender-specific characteristics associated with attrition. Methods: This was a retrospective patient record review of 3919 HIV-infected patients aged >= 15 years who initiated ART between 2007 and 2009 in 40 randomly selected ART facilities countrywide. Results: Compared to females, males had more documented active tuberculosis (12% vs. 9%; p < 0.02) and a lower median CD4 cell count (117 cells/mu l vs. 143 cells/mu l; p < 0.001) at ART initiation. Males had a higher risk of attrition (adjusted hazard ratio (AHR) 1.28, 95% confidence interval (CI) 1.10-1.49) and mortality (AHR 1.56, 95% CI 1.10-2.20). Factors associated with attrition for both sexes were lower baseline weight (<45 kg and 45-60 kg vs. >60 kg), initiating ART at an urban health facility, and care at central/provincial or district/mission hospitals vs. primary healthcare facilities. Conclusions: Our findings show that males presented late for ART initiation compared to females. Similar to other studies, males had higher patient attrition and mortality compared to females and this may be attributed in part to late presentation for HIV treatment and care. These observations highlight the need to encourage early HIV testing and enrolment into HIV treatment and care, and eventually patient retention on ART, particularly amongst men. (C) 2014 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. C1 [Takarinda, Kudakwashe C.; Mutasa-Apollo, Tsitsi; Mugurungi, Owen] Minist Hlth & Child Care, AIDS & TB Unit, Harare, Zimbabwe. [Takarinda, Kudakwashe C.; Harries, Anthony D.] Int Union TB & Lung Dis, Paris, France. [Harries, Anthony D.] London Sch Hyg & Trop Med, Dept Clin Res, London WC1, England. [Shiraishi, Ray W.; Abdul-Quader, Abu] Ctr Dis Control & Prevent CDC, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA USA. RP Takarinda, KC (reprint author), Minist Hlth & Child Care, AIDS & TB Unit, POB CY 1122, Harare, Zimbabwe. EM ktakarinda@theunion.org FU President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC) FX The project has been supported by the President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention (CDC) as part of country activities. Technical support was also provided through the International Union Against Tuberculosis and Lung Disease (IUATLD). NR 38 TC 8 Z9 9 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 EI 1878-3511 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JAN PY 2015 VL 30 BP 98 EP 105 DI 10.1016/j.ijid.2014.11.009 PG 8 WC Infectious Diseases SC Infectious Diseases GA CB3WL UT WOS:000349560000021 PM 25462184 ER PT J AU Mathison, BA Gerth, WJ Pritt, BS Baugh, S AF Mathison, Blaine A. Gerth, William J. Pritt, Bobbi S. Baugh, Stephen TI Introduction of the exotic tick Hyalomma truncatum on a human with travel to Ethiopia: A case report SO TICKS AND TICK-BORNE DISEASES LA English DT Review DE Hyalomma; Ticks; Exotic; Vector-borne ID CONGO HEMORRHAGIC-FEVER; GENUS HYALOMMA; PARASITIC STAGES; ACARI IXODIDAE; UNITED-STATES; TONELLI RONDELLI; 1ST DESCRIPTION; SPOTTED-FEVER; SPECIES ACARI; REDESCRIPTION AB An Oregon resident returned from a photography trip to Ethiopia with a male Hyalomma truncatum tick attached to the skin on his lower back. The tick was identified morphologically and deposited in the U.S. National Tick Collection housed at Georgia Southern University, Statesboro, Georgia. The public health importance of Hyalomma species of ticks and diagnostic dilemmas with identifying exotic ticks imported into the U.S. are discussed. Published by Elsevier GmbH. C1 [Mathison, Blaine A.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. [Gerth, William J.] Oregon State Univ, Plant Clin, Corvallis, OR 97331 USA. [Pritt, Bobbi S.] Mayo Clin, Rochester, MN USA. [Baugh, Stephen] Legacy Med Grp Northwest, Portland, OR USA. RP Mathison, BA (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. EM gqa4@cdc.gov OI Pritt, Bobbi/0000-0003-0261-1326 FU Intramural CDC HHS [CC999999] NR 38 TC 4 Z9 4 U1 0 U2 4 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2015 VL 6 IS 2 BP 152 EP 154 DI 10.1016/j.ttbdis.2014.11.005 PG 3 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA CB6JN UT WOS:000349733400011 PM 25435012 ER PT J AU Castillo, CG Eremeeva, ME Paskewitz, SM Sloan, LM Lee, X Irwin, WE Tonsberg, S Pritt, BS AF Castillo, Caroline G. Eremeeva, Marina E. Paskewitz, Susan M. Sloan, Lynne M. Lee, Xia Irwin, William E. Tonsberg, Stefan Pritt, Bobbi S. TI Detection of human pathogenic Ehrlichia muris-like agent in Peromyscus leucopus SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE Ehrlichia muris; Ehrlichia muris-like (EML) agent; Ehrlichiosis; Peromyscus ID UNITED-STATES; ANAPLASMOSIS; RUSSIA; TICKS AB An Ehrlichia muris-like (EML) bacterium was recently detected in humans and Ixodes scapularis ticks in Minnesota and Wisconsin. The reservoir for this agent is unknown. To investigate the occurrence of the EML agent, groEL PCR testing and sequencing was performed on blood from small mammals and white-tailed deer that were collected in areas where human and tick infections were previously demonstrated. DNA of the EML agent was detected in two Peromyscus leucopus of 146 small mammals (1.4%); while 181 O. virgthianus tested negative. This report provides the first evidence that DNA from the EML agent is found in Peromyscus leucopus, the same animal that is a reservoir for Anaplasma phagocytophilum in this region. The role of white-tailed deer remains inconclusive. Further sampling is warranted to understand the spatial and temporal distribution, transmission and maintenance of this pathogen. (C) 2014 Elsevier GmbH. All rights reserved. C1 [Castillo, Caroline G.; Sloan, Lynne M.; Pritt, Bobbi S.] Mayo Clin, Rochester, MN 55905 USA. [Eremeeva, Marina E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Paskewitz, Susan M.; Lee, Xia] Univ Wisconsin, Madison, WI USA. [Irwin, William E.; Tonsberg, Stefan] US Army Publ Hlth Command Reg West, Washington, DC USA. RP Pritt, BS (reprint author), Mayo Clin, 200 1st St SW, Rochester, MN 55905 USA. EM Pritt.bobbi@mayo.edu OI Pritt, Bobbi/0000-0003-0261-1326 NR 11 TC 4 Z9 4 U1 1 U2 10 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X EI 1877-9603 J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2015 VL 6 IS 2 BP 155 EP 157 DI 10.1016/j.ttbdis.2014.11.006 PG 3 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA CB6JN UT WOS:000349733400012 PM 25481346 ER PT J AU Plucinski, MM Talundzic, E Morton, L Dimbu, PR Macaia, AP Fortes, F Goldman, I Lucchi, N Stennies, G MacArthur, JR Udhayakumar, V AF Plucinski, Mateusz M. Talundzic, Eldin Morton, Lindsay Dimbu, Pedro Rafael Macaia, Aleixo Panzo Fortes, Filomeno Goldman, Ira Lucchi, Naomi Stennies, Gail MacArthur, John R. Udhayakumar, Venkatachalam TI Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for Treatment of Uncomplicated Malaria in Children in Zaire and Uige Provinces, Angola SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; ARTEMISININ RESISTANCE; MICROSATELLITE MARKERS; POPULATION PHARMACOKINETICS; RANDOMIZED-TRIAL; DRUG-RESISTANCE; SAFETY; POLYMORPHISMS; CAMBODIA; UGANDA AB The development of resistance to antimalarials is a major challenge for global malaria control. Artemisinin-based combination therapies, the newest class of antimalarials, are used worldwide but there have been reports of artemisinin resistance in Southeast Asia. In February through May 2013, we conducted open-label, nonrandomized therapeutic efficacy studies of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) in Zaire and Uige Provinces in northern Angola. The parasitological and clinical responses to treatment in children with uncomplicated Plasmodium falciparum monoinfection were measured over 28 days, and the main outcome was a PCR-corrected adequate clinical and parasitological response (ACPR) proportion on day 28. Parasites from treatment failures were analyzed for the presence of putative molecular markers of resistance to lumefantrine and artemisinins, including the recently identified mutations in the K13 propeller gene. In the 320 children finishing the study, 25 treatment failures were observed: 24 in the AL arms and 1 in the DP arm. The PCR-corrected ACPR proportions on day 28 for AL were 88% (95% confidence interval [CI], 78 to 95%) in Zaire and 97% (91 to 100%) in Uige. For DP, the proportions were 100% (95 to 100%) in Zaire, and 100% (96 to 100%) in Uige. None of the treatment failures had molecular evidence of artemisinin resistance. In contrast, 91% of AL late-treatment failures had markers associated with lumefantrine resistance on the day of failure. The absence of molecular markers for artemisinin resistance and the observed efficacies of both drug combinations suggest no evidence of artemisinin resistance in northern Angola. There is evidence of increased lumefantrine resistance in Zaire, which should continue to be monitored. C1 [Plucinski, Mateusz M.; Talundzic, Eldin; Morton, Lindsay; Goldman, Ira; Lucchi, Naomi; Stennies, Gail; MacArthur, John R.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA 30329 USA. [Plucinski, Mateusz M.; Talundzic, Eldin; Morton, Lindsay; Goldman, Ira; Lucchi, Naomi; Stennies, Gail; MacArthur, John R.; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Presidents Malaria Initiat, Div Parasit Dis & Malaria, Atlanta, GA 30329 USA. [Plucinski, Mateusz M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30329 USA. [Dimbu, Pedro Rafael; Fortes, Filomeno] Minist Hlth, Natl Malaria Control Program, Luanda, Angola. [Macaia, Aleixo Panzo] Minist Hlth, Field Epidemiol & Lab Training Program, Luanda, Angola. RP Plucinski, MM (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, 4770 Buford Highway,Mail Stop F-12, Atlanta, GA 30329 USA. EM mplucinski@cdc.gov FU Centers for Disease Control and Prevention; President's Malaria Initiative FX This work was supported by the Centers for Disease Control and Prevention and the President's Malaria Initiative. NR 35 TC 14 Z9 14 U1 2 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JAN PY 2015 VL 59 IS 1 BP 437 EP 443 DI 10.1128/AAC.04181-14 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CA0LO UT WOS:000348609500053 PM 25367912 ER PT J AU Reeves, AZ Campbell, PJ Willby, MJ Posey, JE AF Reeves, Analise Z. Campbell, Patricia J. Willby, Melisa J. Posey, James E. TI Disparities in Capreomycin Resistance Levels Associated with the rrs A1401G Mutation in Clinical Isolates of Mycobacterium tuberculosis SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID 16S RIBOSOMAL-RNA; DRUG-RESISTANCE; MOLECULAR ANALYSIS; CROSS-RESISTANCE; KANAMYCIN; AMIKACIN; GENE; AMINOGLYCOSIDES; MUTAGENESIS; SMEGMATIS AB As the prevalence of multidrug-resistant and extensively drug-resistant tuberculosis strains continues to rise, so does the need to develop accurate and rapid molecular tests to complement time-consuming growth-based drug susceptibility testing. Performance of molecular methods relies on the association of specific mutations with phenotypic drug resistance and while considerable progress has been made for resistance detection of first-line antituberculosis drugs, rapid detection of resistance for second-line drugs lags behind. The rrs A1401G allele is considered a strong predictor of cross-resistance between the three second-line injectable drugs, capreomycin (CAP), kanamycin, and amikacin. However, discordance is often observed between the rrs A1401G mutation and CAP resistance, with up to 40% of rrs A1401G mutants being classified as CAP susceptible. We measured the MICs to CAP in 53 clinical isolates harboring the rrs A1401G mutation and found that the CAP MICs ranged from 8 mu g/ml to 40 mu g/ml. These results were drastically different from engineered A1401G mutants generated in isogenic Mycobacterium tuberculosis, which exclusively exhibited high-level CAP MICs of 40 mu g/ml. These data support the results of prior studies, which suggest that the critical concentration of CAP (10 mu g/ml) used to determine resistance by indirect agar proportion may be too high to detect all CAP-resistant strains and suggest that a larger percentage of resistant isolates could be identified by lowering the critical concentration. These data also suggest that differences in resistance levels among clinical isolates are possibly due to second site or compensatory mutations located elsewhere in the genome. C1 [Reeves, Analise Z.; Campbell, Patricia J.; Willby, Melisa J.; Posey, James E.] Ctr Dis Control & Prevent, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30329 USA. [Campbell, Patricia J.] Emory Univ, Dept Microbiol & Immunol, Microbiol & Mol Genet Grad Program, Atlanta, GA 30322 USA. RP Posey, JE (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30329 USA. EM jposey@cdc.gov NR 31 TC 6 Z9 6 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JAN PY 2015 VL 59 IS 1 BP 444 EP 449 DI 10.1128/AAC.04438-14 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA CA0LO UT WOS:000348609500054 PM 25385119 ER PT J AU Thompson, KM Tebbens, RJD Pallansch, MA Wassilak, SGF Cochi, SL AF Thompson, Kimberly M. Tebbens, Radboud J. Duintjer Pallansch, Mark A. Wassilak, Steven G. F. Cochi, Stephen L. TI Polio Eradicators Use Integrated Analytical Models to Make Better Decisions SO INTERFACES LA English DT Article DE polio; system dynamics; risk analysis; decision analysis; transmission model ID VACCINE-DERIVED POLIOVIRUS; POPULATION IMMUNITY; ECONOMIC-ANALYSIS; RISK-MANAGEMENT; GLOBAL POLICIES; POLIOMYELITIS; DISEASE; FUTURE; TRANSMISSION; OUTBREAKS AB Achieving global polio eradication requires that global stakeholders coordinate and cooperate to invest human and financial resources in interventions that prevent virus transmission. Reaching this goal depends on effective tools and interventions, and their optimal use. Poliovirus transmission occurs in a complex global system with rapidly evolving viruses that readily cross international borders. The U.S. Centers for Disease Control and Prevention, one of four spearheading partners of the Global Polio Eradication Initiative (GPEI), initiated a collaboration with Kid Risk, Inc. to develop and apply integrated analytical models to answer high-stakes policy questions related to managing the risks of polioviruses with consideration of human health and economic outcomes. Over the last decade, the collaboration innovatively combined numerous operations research and management science tools, including simulation, decision and risk analysis, system dynamics, and optimization to help policy makers understand and quantify the implications of their choices. These integrated modeling efforts helped motivate faster responses to polio outbreaks, leading to a global resolution and significantly reduced response time and outbreak sizes. Insights from the models also underpinned a 192-country resolution to coordinate global cessation of the use of one of the two vaccines after wild poliovirus eradication (i.e., allowing continued use of the other vaccine as desired). Finally, the model results helped us to make the economic case for a continued commitment to polio eradication by quantifying the value of prevention and showing the health and economic outcomes associated with the alternatives. The work helped to raise the billions of dollars needed to support polio eradication. The investments will prevent devastating cases of polio and realize an estimated $40-$50 billion in net benefits by the countries covered by the GPEI, while protecting the significantly larger net benefits enjoyed by the countries that stopped wild poliovirus transmission without support of the GPEI. C1 [Thompson, Kimberly M.; Tebbens, Radboud J. Duintjer] Kid Risk Inc, Orlando, FL 32832 USA. [Pallansch, Mark A.; Wassilak, Steven G. F.; Cochi, Stephen L.] US Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Thompson, KM (reprint author), Kid Risk Inc, Orlando, FL 32832 USA. EM kimt@kidrisk.org; rdt@kidrisk.org; map1@cdc.gov; sgw1@cdc.gov; slc1@cdc.gov FU CDC [U66 IP000169]; U.S. Centers for Disease Control and Prevention (CDC) [U66 IP000169, U50/CCU300860, U01 IP000029, NVPO N37 (FY2005) 200-2010-M-33379, 200-2010-M-33679, 200-2010-M-35172]; World Health Organization (WHO) [APW200179134]; Bill & Melinda Gates Foundation [4533-17492, 4533-18487, 4533-21031, 4533-23446] FX We thank Dr. Bruce Aylward for providing the video recorded quotes about the impacts of our work, which we used in the Edelman Award presentations, and Drs. Aylward, Carol Pandak, and Walter Orenstein for providing stakeholder perspectives in discussions with the Edelman judges. We thank Katerina Alves, Sona Bari, Thomas Bell, Christopher Black, Ivana Boko, Lee Bookman, Louis Boviero, James Cosgrove, Christine Fares, Christine Feig, Jean-Marc Glinz, Brian Hirten, Alan Janssen, Todd Jordan, Sarah Poser, Oliver Rosenbauer, Bryon Skinner, and Jeanette St. Pierre for their help with preparing the audiovisual materials for our presentation, and the GPEI partners for the images used. We thank Sid Hess, Pelin Pekgun, Carrie Beam, and all of the Edelman judges and editors for providing comments. The first two authors acknowledge support for this article from CDC Cooperative Agreement [U66 IP000169]. The collaborative work described in this piece includes research performed with financial support for Kid Risk, Inc. and research in the form of grants and contracts from the U.S. Centers for Disease Control and Prevention (CDC) [Grants U50/CCU300860, U01 IP000029, NVPO N37 (FY2005) 200-2010-M-33379, 200-2010-M-33679, 200-2010-M-35172, and U66 IP000169]; the World Health Organization (WHO) [APW200179134]; the Bill & Melinda Gates Foundation [4533-17492, 4533-18487, 4533-21031, 4533-23446]; and unrestricted gifts to the Harvard Kids Risk Project. Finally, we thank collaborators from Kid Risk, Inc., including Dominika Kalkowska, Jong-Hoon Kim, and Kasper Kisjes; from CDC, including James Alexander, Lorraine Alexander, Larry Anderson, Gregory Armstrong, Albert Barskey, Carla Boudreau, Brenton Burkholder, Cara Burns, Victor Caceres, Jason Cecil, Susan Chu, Paul Chenoweth, Kathleen Gallagher, Howard Gary, John Glasser, Steve Hadler, Karen Hennessey, Hamid Jafari, Julie Jenks, Denise Johnson, Bob Keegan, Olen Kew, Nino Khetsuriani, Robb Linkins, Benjamin Lopman, Naile Malakmadze, Rebecca Martin, Eric Mast, Steve McLaughlin, Steve Oberste, Patrick O'Connor, Becky Prevots, Hardeep Sandhu, Nalinee Sangrujee, Anne Schuchat, Jean Smith, Philip Smith, Peter Strebel, Linda Venczel, Gregory Wallace, Margie Watkins, and Bruce Weniger; and from the WHO, including (in addition to those mentioned previously) Fred Caillette, Claire Chauvin, Philippe Duclos, Esther de Gourville, Hans Everts, Marta Gacic-Dobo, Tracey Goodman, Ulla Griffiths, David Heymann, Scott Lambert, Asta Lim, Jennifer Linkins, Patrick Lydon, Chris Maher, Linda Muller, Roland Sutter, Rudi Tangermann, Chris Wolff, and David Wood. We also thank the Global Polio Laboratory Network, Harrie van der Avoort, Francois Bompart, Anthony Burton, Konstantin Chumakov, Laurent Coudeville, Walter Dowdle, Paul Fine, Michael Galway, Shanelle Hall, Neal Halsey, Tapani Hovi, Kun Hu, Jacob John, Samuel Katz, Tracy Lieu, Marc Lipsitch, Anton van Loon, Apoorva Mallya, Elizabeth Miller, Phil Minor, John Modlin, Van Hung Nguyen, Peter Patriarca, Christina Pedreira, Stanley Plotkin, Hazhir Rahmandad, Robert Scott, John Sever, Thomas Sorensen, John Sterman, Robert Weibel, Jay Wenger, and Peter Wright. NR 52 TC 5 Z9 5 U1 1 U2 8 PU INFORMS PI CATONSVILLE PA 5521 RESEARCH PARK DR, SUITE 200, CATONSVILLE, MD 21228 USA SN 0092-2102 EI 1526-551X J9 INTERFACES JI Interfaces PD JAN-FEB PY 2015 VL 45 IS 1 BP 5 EP 25 DI 10.1287/inte.2014.0769 PG 21 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA CB1HM UT WOS:000349378000002 ER PT J AU Bai, Y Hayman, DTS Mckee, CD Kosoy, MY AF Bai, Ying Hayman, David T. S. Mckee, Clifton D. Kosoy, Michael Y. TI Classification of Bartonella Strains Associated with Straw-Colored Fruit Bats (Eidolon helvum) across Africa Using a Multi-locus Sequence Typing Platform SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID CAT-SCRATCH DISEASE; SP-NOV; HENSELAE; SPP.; RECOMBINATION; VINSONII; PATHOGEN; REVEALS; RODENTS; PATIENT AB Bartonellae are facultative intracellular bacteria and are highly adapted to their mammalian host cell niches. Straw-colored fruit bats (Eidolon helvum) are commonly infected with several bartonella strains. To elucidate the genetic diversity of these bartonella strains, we analyzed 79 bartonella isolates from straw-colored fruit bats in seven countries across Africa (Cameroon, Annobon island of Equatorial Guinea, Ghana, Kenya, Nigeria, Tanzania, and Uganda) using a multi-locus sequencing typing (MLST) approach based on nucleotide sequences of eight loci (ftsZ, gltA, nuoG, ribC, rpoB, ssrA, ITS, and 16S rRNA). The analysis of each locus but ribC demonstrated clustering of the isolates into six genogroups (E1 - E5 and Ew), while ribC was absent in the isolates belonging to the genogroup Ew. In general, grouping of all isolates by each locus was mutually supportive; however, nuoG, gltA, and rpoB showed some incongruity with other loci in several strains, suggesting a possibility of recombination events, which were confirmed by network analyses and recombination/mutation rate ratio (r/m) estimations. The MLST scheme revealed 45 unique sequence types (ST1 - 45) among the analyzed bartonella isolates. Phylogenetic analysis of concatenated sequences supported the discrimination of six phylogenetic lineages (E1 - E5 and Ew) corresponding to separate and unique Bartonella species. One of the defined lineages, Ew, consisted of only two STs (ST1 and ST2), and comprised more than one-quarter of the analyzed isolates, while other lineages contained higher numbers of STs with a smaller number of isolates belonging to each lineage. The low number of allelic polymorphisms of isolates belonging to Ew suggests a more recent origin for this species. Our findings suggest that at least six Bartonella species are associated with straw-colored fruit bats, and that distinct STs can be found across the distribution of this bat species, including in populations of bats which are genetically distinct. C1 [Bai, Ying; Mckee, Clifton D.; Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Hayman, David T. S.] Massey Univ, Mol Epidemiol & Publ Hlth Lab, Infect Dis Res Ctr, Palmerston North, New Zealand. [Mckee, Clifton D.] Colorado State Univ, Dept Biol, Ft Collins, CO 80523 USA. RP Bai, Y (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. EM bby5@cdc.gov NR 45 TC 4 Z9 4 U1 2 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2015 VL 9 IS 1 AR e0003478 DI 10.1371/journal.pntd.0003478 PG 16 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CB0LR UT WOS:000349318100055 PM 25635826 ER PT J AU Ghinai, R El-Duah, P Chi, KH Pillay, A Solomon, AW Bailey, RL Agana, N Mabey, DCW Chen, CY Adu-Sarkodie, Y Marks, M AF Ghinai, Rosanna El-Duah, Philip Chi, Kai-Hua Pillay, Allan Solomon, Anthony W. Bailey, Robin L. Agana, Nsiire Mabey, David C. W. Chen, Cheng-Yen Adu-Sarkodie, Yaw Marks, Michael TI A Cross-Sectional Study of 'Yaws' in Districts of Ghana Which Have Previously Undertaken Azithromycin Mass Drug Administration for Trachoma Control SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID PAPUA-NEW-GUINEA; HAEMOPHILUS-DUCREYI; TREPONEMA-PALLIDUM; SKIN ULCERS; PCR ASSAY; RESISTANCE; CHILDREN; INFECTION; SYPHILIS; TRIAL AB Yaws, caused by Treponema pallidum ssp. pertenue, is reportedly endemic in Ghana. Mass distribution of azithromycin is now the cornerstone of the WHO yaws eradication campaign. Mass distribution of azithromycin at a lower target dose was previously undertaken in two regions of Ghana for the control of trachoma. Ongoing reporting of yaws raises the possibility that resistance may have emerged in T. pallidum pertenue, or that alternative infections may be responsible for some of the reported cases. We conducted a cross-sectional survey in thirty communities in two districts of Ghana where MDA for trachoma had previously been conducted. Children aged 5-17 years with ulcerative lesions compatible with yaws were enrolled. Samples for treponemal serology and lesion PCR were collected from all children. 90 children with 98 lesions were enrolled. Syphilis serology was negative in all of them. PCR for T. pallidum ssp pertenue was negative in all children, but Haemophilus ducreyi DNA was detected in 9 lesions. In these communities, previously treated for trachoma, we found no evidence of ongoing transmission of yaws. H. ducreyi was associated with a proportion of skin lesions, but the majority of lesions remain unexplained. Integration of diagnostic testing into both pre and post-MDA surveillance systems is required to better inform yaws control programmes. C1 [Ghinai, Rosanna; Solomon, Anthony W.; Bailey, Robin L.; Mabey, David C. W.; Marks, Michael] London Sch Hyg & Trop Med, Dept Clin Res, London WC1, England. [El-Duah, Philip; Adu-Sarkodie, Yaw] Kwame Nkrumah Univ Sci & Technol, Sch Med Sci, Dept Clin Microbiol, Kumasi, Ghana. [Chi, Kai-Hua; Pillay, Allan; Chen, Cheng-Yen] Ctr Dis Control & Prevent, Lab Reference & Res Branch, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Solomon, Anthony W.; Bailey, Robin L.; Mabey, David C. W.; Marks, Michael] Univ Coll London Hosp NHS Trust, Hosp Trop Dis, London, England. [Agana, Nsiire] Ghana Hlth Serv, Publ Hlth Div, Accra, Ghana. RP Ghinai, R (reprint author), London Sch Hyg & Trop Med, Dept Clin Res, London WC1, England. EM michael.marks@lshtm.ac.uk OI Mabey, David/0000-0002-0031-8276; Marks, Michael/0000-0002-7585-4743; Solomon, Anthony/0000-0001-7101-6649 FU Royal Society for Tropical Medicine and Hygiene [000409]; Wellcome Trust Clinical Research Fellowship [102807]; Wellcome Trust Intermediate Clinical Fellowship [098521] FX Costs of fieldwork for this study were supported by a grant from the Royal Society for Tropical Medicine and Hygiene (Small Grant Ref 000409). MM was supported by a Wellcome Trust Clinical Research Fellowship (102807). AWS was supported by a Wellcome Trust Intermediate Clinical Fellowship (098521). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 22 TC 14 Z9 14 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2015 VL 9 IS 1 AR e0003496 DI 10.1371/journal.pntd.0003496 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CB0LR UT WOS:000349318100059 PM 25632942 ER PT J AU Pitassi, LHU Diniz, PPVD Scorpio, DG Drummond, MR Lania, BG Barjas-Castro, ML Gilioli, R Colombo, S Sowy, S Breitschwerdt, EB Nicholson, WL Velho, PENF AF Urso Pitassi, Luiza Helena Vissotto De Paiva Diniz, Pedro Paulo Scorpio, Diana Gerardi Drummond, Marina Rovani Lania, Bruno Grosselli Barjas-Castro, Maria Lourdes Gilioli, Rovilson Colombo, Silvia Sowy, Stanley Breitschwerdt, Edward B. Nicholson, William L. Neves Ferreira Velho, Paulo Eduardo TI Bartonella spp. Bacteremia in Blood Donors from Campinas, Brazil SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID VINSONII SUBSP BERKHOFFII; MOLECULAR PREVALENCE; INFECTIOUS-DISEASE; GROWTH-MEDIUM; HENSELAE; CATS; DOGS; SENSITIVITY; QUINTANA; PATIENT AB Bartonella species are blood-borne, re-emerging organisms, capable of causing prolonged infection with diverse disease manifestations, from asymptomatic bacteremia to chronic debilitating disease and death. This pathogen can survive for over a month in stored blood. However, its prevalence among blood donors is unknown, and screening of blood supplies for this pathogen is not routinely performed. We investigated Bartonella spp. prevalence in 500 blood donors from Campinas, Brazil, based on a cross-sectional design. Blood samples were inoculated into an enrichment liquid growth medium and sub-inoculated onto blood agar. Liquid culture samples and Gram-negative isolates were tested using a genus specific ITS PCR with amplicons sequenced for species identification. Bartonella henselae and Bartonella quintana antibodies were assayed by indirect immunofluorescence. B. henselae was isolated from six donors (1.2%). Sixteen donors (3.2%) were Bartonella-PCR positive after culture in liquid or on solid media, with 15 donors infected with B. henselae and one donor infected with Bartonella clarridgeiae. Antibodies against B. henselae or B. quintana were found in 16% and 32% of 500 blood donors, respectively. Serology was not associated with infection, with only three of 16 Bartonella-infected subjects seropositive for B. henselae or B. quintana. Bartonella DNA was present in the bloodstream of approximately one out of 30 donors from a major blood bank in South America. Negative serology does not rule out Bartonella spp. infection in healthy subjects. Using a combination of liquid and solid cultures, PCR, and DNA sequencing, this study documents for the first time that Bartonella spp. bacteremia occurs in asymptomatic blood donors. Our findings support further evaluation of Bartonella spp. transmission which can occur through blood transfusions. C1 [Urso Pitassi, Luiza Helena; Drummond, Marina Rovani; Lania, Bruno Grosselli; Neves Ferreira Velho, Paulo Eduardo] State Univ Campinas UNICAMP, Dept Med, Div Dermatol, Campinas, SP, Brazil. [Vissotto De Paiva Diniz, Pedro Paulo; Sowy, Stanley] Western Univ Hlth Sci, Coll Vet Med, Pomona, CA USA. [Scorpio, Diana Gerardi] Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD USA. [Barjas-Castro, Maria Lourdes] State Univ Campinas UNICAMP, Dept Med, Ctr Hematol & Hemoterapia HEMOCTR, Campinas, SP, Brazil. [Gilioli, Rovilson] State Univ Campinas UNICAMP, Multidisciplinary Ctr Biol Invest CEMIB, Lab Anim Qual Control, Campinas, SP, Brazil. [Colombo, Silvia] Secretaria Estado Saude Sao Paulo, Dept Virol, Adolfo Lutz Inst IAL, Sao Paulo, Brazil. [Breitschwerdt, Edward B.] N Carolina State Univ, Coll Vet Med, Intracellular Pathogens Res Lab, Raleigh, NC USA. [Nicholson, William L.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA USA. RP Pitassi, LHU (reprint author), State Univ Campinas UNICAMP, Dept Med, Div Dermatol, Campinas, SP, Brazil. EM diniz@westernu.edu RI Lania, Bruno/J-7496-2012 OI Lania, Bruno/0000-0003-4949-7444 FU Faculty Grant in Global Health from the Johns Hopkins Center for Global Health; FAEPEX-UNICAMP (Fundo de Apoio ao Ensino, a Pesquisa e a Extensao-UNICAMP) [234/10, 292/10]; Office of the Vice President for Research and Biotechnology, Western University, Western University of Health Sciences, Pomona, CA FX This project was the basis for the PhD thesis of LHUP and was partially funded by the Faculty Grant in Global Health to DGS from the Johns Hopkins Center for Global Health; a grant from FAEPEX-UNICAMP (Fundo de Apoio ao Ensino, a Pesquisa e a Extensao-UNICAMP) under protocols number 234/10 and 292/10; and a summer research scholarship to SS from the Office of the Vice President for Research and Biotechnology, Western University, Western University of Health Sciences, Pomona, CA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 45 TC 10 Z9 10 U1 0 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD JAN PY 2015 VL 9 IS 1 AR e0003467 DI 10.1371/journal.pntd.0003467 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA CB0LR UT WOS:000349318100052 PM 25590435 ER PT J AU Pitzer, VE Viboud, C Alonso, WJ Wilcox, T Metcalf, CJ Steiner, CA Haynes, AK Grenfell, BT AF Pitzer, Virginia E. Viboud, Cecile Alonso, Wladimir J. Wilcox, Tanya Metcalf, C. Jessica Steiner, Claudia A. Haynes, Amber K. Grenfell, Bryan T. TI Environmental Drivers of the Spatiotemporal Dynamics of Respiratory Syncytial Virus in the United States SO PLOS PATHOGENS LA English DT Article ID YOUNG-CHILDREN; NATIONAL-SURVEILLANCE; MEASLES EPIDEMICS; GROUP-B; GROUP-A; TRANSMISSION DYNAMICS; SPATIAL HIERARCHIES; INFECTIOUS-DISEASES; TRACT INFECTIONS; KILIFI DISTRICT AB Epidemics of respiratory syncytial virus (RSV) are known to occur in wintertime in temperate countries including the United States, but there is a limited understanding of the importance of climatic drivers in determining the seasonality of RSV. In the United States, RSV activity is highly spatially structured, with seasonal peaks beginning in Florida in November through December and ending in the upper Midwest in February-March, and prolonged disease activity in the southeastern US. Using data on both age-specific hospitalizations and laboratory reports of RSV in the US, and employing a combination of statistical and mechanistic epidemic modeling, we examined the association between environmental variables and state-specific measures of RSV seasonality. Temperature, vapor pressure, precipitation, and potential evapotranspiration (PET) were significantly associated with the timing of RSV activity across states in univariate exploratory analyses. The amplitude and timing of seasonality in the transmission rate was significantly correlated with seasonal fluctuations in PET, and negatively correlated with mean vapor pressure, minimum temperature, and precipitation. States with low mean vapor pressure and the largest seasonal variation in PET tended to experience biennial patterns of RSV activity, with alternating years of "early-big" and "ate-small" epidemics. Our model for the transmission dynamics of RSV was able to replicate these biennial transitions at higher amplitudes of seasonality in the transmission rate. This successfully connects environmental drivers to the epidemic dynamics of RSV; however, it does not fully explain why RSV activity begins in Florida, one of the warmest states, when RSV is a winter-seasonal pathogen. Understanding and predicting the seasonality of RSV is essential in determining the optimal timing of immunoprophylaxis. C1 [Pitzer, Virginia E.] Yale Univ, Yale Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT 06520 USA. [Pitzer, Virginia E.; Viboud, Cecile; Alonso, Wladimir J.; Wilcox, Tanya; Grenfell, Bryan T.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Metcalf, C. Jessica] Univ Oxford, Dept Zool, Oxford, England. [Metcalf, C. Jessica; Grenfell, Bryan T.] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA. [Steiner, Claudia A.] US Dept HHS, Healthcare Cost & Utilizat Project, Ctr Delivery Org & Markets, Agcy Healthcare Res & Qual, Rockville, MD USA. [Haynes, Amber K.] Ctr Dis Control & Prevent, Epidemiol Branch, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Pitzer, VE (reprint author), Yale Univ, Yale Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT 06520 USA. EM virginia.pitzer@yale.edu OI Pitzer, Virginia/0000-0003-1015-2289 FU Bill & Melinda Gates Foundation (Vaccine Modeling Initiative); Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Science & Technology Directorate, Department of Homeland Security; Fogarty International Center, National Institutes of Health FX This work was supported by the Bill & Melinda Gates Foundation (Vaccine Modeling Initiative; https://vaccinemodeling.org/) and the Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Science & Technology Directorate, Department of Homeland Security, and the Fogarty International Center, National Institutes of Health (http://www.fic.nih.gov/about/staff/pages/epidemiology-population.aspx) (VEP, CJM, and BTG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 71 TC 14 Z9 14 U1 0 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7366 EI 1553-7374 J9 PLOS PATHOG JI PLoS Pathog. PD JAN PY 2015 VL 11 IS 1 AR e1004591 DI 10.1371/journal.ppat.1004591 PG 14 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA CA7OF UT WOS:000349106100023 PM 25569275 ER PT J AU Warner, AE Schaefer, MK Patel, PR Drobeniuc, J Xia, GL Lin, YL Khudyakov, Y Vonderwahl, C Miller, L Thompson, ND AF Warner, Amy E. Schaefer, Melissa K. Patel, Priti R. Drobeniuc, Jan Xia, Guoliang Lin, Yulin Khudyakov, Yury Vonderwahl, CandaceW. Miller, Lisa Thompson, Nicola D. TI Outbreak of hepatitis C virus infection associated with narcotics diversion by an hepatitis C virus-infected surgical technician SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article DE Drug theft in healthcare; Healthcare associated infections; Unsafe injection practice ID HEALTH-CARE SETTINGS; TRANSMISSION; BACTEREMIA AB Background: Drug diversion by health care personnel poses a risk for serious patient harm. Public health identified 2 patients diagnosed with acute hepatitis C virus (HCV) infection who shared a common link with a hospital. Further investigation implicated a drug-diverting, HCV-infected surgical technician who was subsequently employed at an ambulatory surgical center. Methods: Patients at the 2 facilities were offered testing for HCV infection if they were potentially exposed. Serum from the surgical technician and patients testing positive for HCV but without evidence of infection before their surgical procedure was further tested to determine HCV genotype and quasi-species sequences. Parenteral medication handling practices at the 2 facilities were evaluated. Results: The 2 facilities notified 5970 patients of their possible exposure to HCV, 88% of whom were tested and had results reported to the state public health departments. Eighteen patients had HCV highly related to the surgical technician's virus. The surgical technician gained unauthorized access to fentanyl owing to limitations in procedures for securing controlled substances. Conclusions: Public health surveillance identified an outbreak of HCV infection due to an infected health care provider engaged in diversion of injectable narcotics. The investigation highlights the value of public health surveillance in identifying HCV outbreaks and uncovering a method of drug diversion and its impacts on patients. Copyright (C) 2015 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved. C1 [Warner, Amy E.; Vonderwahl, CandaceW.; Miller, Lisa] Colorado Dept Publ Hlth & Environm, Div Dis Control & Environm Epidemiol, Denver, CO 80246 USA. [Schaefer, Melissa K.; Patel, Priti R.] Ctr Dis Control & Prevent, Prevent & Response Branch, Div Healthcare Qual Promot, Atlanta, GA USA. [Drobeniuc, Jan] Ctr Dis Control & Prevent, Assay Dev & Diagnost Reference Lab, Div Viral Hepatitis, Atlanta, GA USA. [Xia, Guoliang; Lin, Yulin; Khudyakov, Yury] Ctr Dis Control & Prevent, Mol Epidemiol Lab, Div Viral Hepatitis, Atlanta, GA USA. [Thompson, Nicola D.] Ctr Dis Control & Prevent, Epidemiol & Surveillance Branch, Div Viral Hepatitis, Atlanta, GA USA. RP Warner, AE (reprint author), Colorado Dept Publ Hlth & Environm, DCEED A-3,4300 Cherry Creek Dr South, Denver, CO 80246 USA. EM Amy.warner@state.co.us FU Intramural CDC HHS [CC999999] NR 25 TC 3 Z9 3 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 EI 1527-3296 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD JAN PY 2015 VL 43 IS 1 BP 53 EP 58 DI 10.1016/j.ajic.2014.09.012 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AY6CG UT WOS:000347654600012 PM 25442395 ER PT J AU Ellis, BH Lankau, EW Ao, T Benson, MA Miller, AB Shetty, S Cardozo, BL Geltman, PL Cochran, J AF Ellis, B. Heidi Lankau, Emily W. Trong Ao Benson, Molly A. Miller, Alisa B. Shetty, Sharmila Cardozo, Barbara Lopes Geltman, Paul L. Cochran, Jennifer TI Understanding Bhutanese Refugee Suicide Through the Interpersonal-Psychological Theory of Suicidal Behavior SO AMERICAN JOURNAL OF ORTHOPSYCHIATRY LA English DT Article DE refugee; suicide; Bhutanese ID HOPKINS SYMPTOM CHECKLIST-25; MENTAL-HEALTH; PERCEIVED BURDENSOMENESS; PSYCHIATRIC-SYMPTOMS; PROTECTIVE FACTORS; BOSNIAN REFUGEES; TRAUMATIC EVENTS; UNITED-STATES; IDEATION; TORTURE AB Attention has been drawn to high rates of suicide among refugees after resettlement and in particular among the Bhutanese refugees. This study sought to understand the apparent high rates of suicide among resettled Bhutanese refugees in the context of the Interpersonal-Psychological Theory of Suicidal Behavior (IPTS). Expanding on a larger investigation of suicide in a randomly selected sample of Bhutanese men and women resettled in Arizona, Georgia, New York, and Texas (Ao et al., 2012), the current study focused on 2 factors, thwarted belongingness and perceived burdensomeness, examined individual and postmigration variables associated with these factors, and explored how they differed by gender. Overall, factors such as poor health were associated with perceived burdensomeness and thwarted belongingness. For men, stressors related to employment and providing for their families were related to feeling burdensome and/or alienated from family and friends, whereas for women, stressors such as illiteracy, family conflict, and being separated from family members were more associated. IPTS holds promise in understanding suicide in the resettled Bhutanese community. C1 [Ellis, B. Heidi; Benson, Molly A.; Miller, Alisa B.] Boston Childrens Hosp, Boston, MA 02115 USA. [Ellis, B. Heidi; Benson, Molly A.; Miller, Alisa B.] Harvard Univ, Sch Med, Dept Psychiat, Cambridge, MA 02138 USA. [Lankau, Emily W.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA. [Trong Ao] Ctr Dis Control & Prevent, Global Dis Detect Branch, Atlanta, GA USA. [Shetty, Sharmila] Ctr Dis Control & Prevent, Immigrant Refugee & Migrant Hlth Branch, Atlanta, GA USA. [Cardozo, Barbara Lopes] Ctr Dis Control & Prevent, Emergency Response & Recovery Branch, Ctr Global Hlth, Atlanta, GA USA. [Geltman, Paul L.] Massachusetts Dept Publ Hlth, Div Global Populat & Infect Dis Prevent, Jamaica Plain, MA USA. [Geltman, Paul L.] Harvard Univ, Sch Med, Dept Pediat, Cambridge, MA 02138 USA. [Cochran, Jennifer] Massachusetts Dept Publ Hlth, Div Global Populat & Infect Dis Prevent, Bur Infect Dis, Jamaica Plain, MA USA. RP Ellis, BH (reprint author), Boston Childrens Hosp, Dept Psychiat, 21 Autumn St,1st Floor, Boston, MA 02115 USA. EM heidi.ellis@childrens.harvard.edu RI Lankau, Emily/C-8057-2011 OI Lankau, Emily/0000-0002-7094-7780 FU Refugee Health Technical Assistance Center - Office of Refugee Resettlement; Centers for Disease Control and Prevention FX This research was supported by the Refugee Health Technical Assistance Center (funded by Office of Refugee Resettlement) and the Centers for Disease Control and Prevention. We thank our Bhutanese colleagues, Radha Adhikari, Tej Mishra, and Luna Mulder, for their thoughtful review of this article and their invaluable contributions to the interpretation of the study's findings and Laura Vonnahme, for her help with data analysis. NR 54 TC 3 Z9 3 U1 4 U2 13 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0002-9432 EI 1939-0025 J9 AM J ORTHOPSYCHIAT JI Am. J. Orthopsychiatr. PD JAN PY 2015 VL 85 IS 1 BP 43 EP 55 DI 10.1037/ort0000028 PG 13 WC Psychiatry; Social Work SC Psychiatry; Social Work GA CA7CS UT WOS:000349075600006 PM 25642653 ER PT S AU Jernigan, DB Cox, NJ AF Jernigan, Daniel B. Cox, Nancy J. BE Caskey, CT TI H7N9: Preparing for the Unexpected in Influenza SO ANNUAL REVIEW OF MEDICINE, VOL 66 SE Annual Review of Medicine LA English DT Review; Book Chapter DE sequencing; preparedness; risk assessment; emerging infection ID A H7N9; A(H7N9) VIRUS; HUMAN INFECTIONS; HIGH-RISK; CHINA; H5N1; TRANSMISSION; SURVEILLANCE; SUBTYPES; MARKETS AB In the years prior to 2013, avian influenza AH7 viruses were a cause of significant poultry mortality; however, human illness was generally mild. In March 2013, a novel influenza A(H7N9) virus emerged in China as an unexpected cause of severe human illness with 36% mortality. Chinese and other public health officials responded quickly, characterizing the virus and identifying more than 400 cases through use of new technologies and surveillance tools made possible by past preparedness and response efforts. Genetic sequencing, glycan-array receptor-binding assays, and ferret studies reveal the H7N9 virus to have increased binding to mammalian respiratory cells and to have mutations associated with higher virus replication rates and illness severity. New risk-assessment tools indicate H7N9 has the potential for further mammalian adaptation with possible human-to-human transmission. Vigilant virologic and epidemiologic surveillance is needed to monitor H7N9 and detect other unexpected novel influenza viruses that may emerge. C1 [Jernigan, Daniel B.; Cox, Nancy J.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30329 USA. RP Jernigan, DB (reprint author), Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30329 USA. EM dbj0@cdc.gov; njc1@cdc.gov NR 39 TC 16 Z9 19 U1 2 U2 17 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA SN 0066-4219 BN 978-0-8243-0566-6 J9 ANNU REV MED JI Annu. Rev. Med. PY 2015 VL 66 BP 361 EP 371 DI 10.1146/annurev-med-010714-112311 PG 11 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA BB9PT UT WOS:000348560300024 PM 25386931 ER PT J AU Ghany, MG Perrillo, R Li, RS Belle, SH Janssen, HLA Terrault, NA Shuhart, MC Lau, DTY Kim, WR Fried, MW Sterling, RK Di Bisceglie, AM Han, SHB Ganova-Raeva, LM Chang, KM Lok, ASF AF Ghany, Marc G. Perrillo, Robert Li, Ruosha Belle, Steven H. Janssen, Harry L. A. Terrault, Norah A. Shuhart, Margaret C. Lau, Daryl T-Y. Kim, W. Ray Fried, Michael W. Sterling, Richard K. Di Bisceglie, Adrian M. Han, Steven-Huy B. Ganova-Raeva, Lilia Milkova Chang, Kyong-Mi Lok, Anna Suk-Fong CA Hepatitis B Res Network TI Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article DE HBeAg; Chronic Hepatitis B Virus Infection; USA; ALT ID UNITED-STATES; HBV INFECTION; EPIDEMIOLOGY; PREVALENCE; WORLDWIDE; DISEASE; BURDEN; HEALTH AB BACKGROUND & AIMS: Chronic hepatitis B virus (HBV) infection is an important cause of cirrhosis and hepatocellular carcinoma worldwide; populations that migrate to the United States and Canada might be affected disproportionately. The Hepatitis B Research Network (HBRN) is a cooperative network of investigators from the United States and Canada, created to facilitate clinical, therapeutic, and translational research in adults and children with hepatitis B. We describe the structure of the network and baseline characteristics of adults with hepatitis B enrolled in the network. METHODS: The HBRN collected data on the clinical characteristics of 1625 adults with chronic HBV infection who are not receiving antiviral therapy from 21 clinical centers in North America. RESULTS: Half of the subjects in the HBRN are men, and the median age is 42 years; 72% are Asian, 15% are black, and 11% are white; with 82% born outside of North America. The most common HBV genotype was B (39%); 74% of subjects were negative for the hepatitis B e antigen. The median serum level of HBV DNA when the study began was 3.6 log(10) IU/mL; 68% of male subjects and 67% of female subjects had alanine aminotransferase levels higher than the normal range. CONCLUSIONS: The HBRN cohort is used to address important clinical and therapeutic questions for North Americans infected with chronic HBV and to guide health policies on HBV prevention and management in North America. C1 [Ghany, Marc G.] NIDDK, Liver Dis Branch, NIH, Bethesda, MD 20892 USA. [Perrillo, Robert] Baylor Univ, Med Ctr, Hepatol Div, Dallas, TX USA. [Li, Ruosha; Belle, Steven H.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA. [Janssen, Harry L. A.] Toronto Western Hosp, Div Gastroenterol, Univ Hlth Network, Toronto, ON M5T 2S8, Canada. [Janssen, Harry L. A.] Toronto Gen Hosp, Div Gastroenterol, Univ Hlth Network, Toronto, ON, Canada. [Terrault, Norah A.] Univ Calif San Francisco, Div Gastroenterol, San Francisco, CA 94143 USA. [Shuhart, Margaret C.] Univ Washington, Harborview Med Ctr, Viral Hepatitis & Liver Clin, Seattle, WA 98104 USA. [Lau, Daryl T-Y.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Gastroenterol, Boston, MA 02215 USA. [Kim, W. Ray] Stanford Univ, Sch Med, Div Gastroenterol, Palo Alto, CA 94304 USA. [Fried, Michael W.] Univ N Carolina, Ctr Liver, Sect Hepatol, Chapel Hill, NC USA. [Sterling, Richard K.] Virginia Commonwealth Univ Hlth Syst, Sect Hepatol, Richmond, VA USA. [Di Bisceglie, Adrian M.] St Louis Univ, Sch Med, Dept Internal Med, St Louis, MO USA. [Han, Steven-Huy B.] Univ Calif Los Angeles, David Geffen Sch Med, Pfleger Liver Inst Clin, Los Angeles, CA 90095 USA. [Ganova-Raeva, Lilia Milkova] Ctr Dis Control & Prevent, Div Viral Hepatitis, Mol Epidemiol & Bioinformat Sequencing Lab, Atlanta, GA USA. [Chang, Kyong-Mi] Univ Penn, Sch Med, Philadelphia Vet Affairs Med Ctr, Penn Ctr Viral Hepatitis, Philadelphia, PA 19104 USA. [Lok, Anna Suk-Fong] Univ Michigan, Div Gastroenterol & Hepatol, Ann Arbor, MI 48109 USA. RP Ghany, MG (reprint author), NIDDK, Liver Dis Branch, NIH, Bdg 10,Room 9B-16,10 Ctr Dr,MSC 1800, Bethesda, MD 20892 USA. EM marcg@intra.niddk.nih.gov OI Barritt, Alfred/0000-0002-4200-3256; Cloonan, Yona/0000-0003-3893-3693; Wahed, Abdus/0000-0001-6911-7221 FU National Institute of Diabetes and Digestive and Kidney Diseases [U01 DK082872, DK082864, DK082874, U01 DK082944, DK082943, DK082919, DK 082843, DK082867, DK082923, DK082871, DK082927, DK082866, DK082863, A-DK-3002-001]; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health; Immunology Center (National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases, Center of Molecular Studies in Digestive and Liver Diseases) [P30DK50306]; Immunology Center (National Institutes of Health Public Health Service Research) [M01RR00040]; National Center for Advancing Translational Sciences, National Institutes of Health [UL1TR000058]; Clinical and Translational Science Awards [UL1TR000004, UL1TR001111, UL1RR024986]; Gilead Sciences, Inc; Roche Molecular Systems through National Institute of Diabetes and Digestive and Kidney Diseases FX The Hepatitis B Research Network was funded by grants from the National Institute of Diabetes and Digestive and Kidney Diseases to the following investigators: U01 DK082872 (W.L.), DK082864 (S.B.), DK082874 (H.J.), U01 DK082944 (N.T.), DK082943 (R.C.), DK082919 (D.T.-Y.L.), DK 082843 (L.R.R.), DK082867 (M.W.F.), DK082923 (R.K.S.), DK082871 (A.D.B.), DK082927 (S.-H.B.H.), DK082866 (K.-M.C.), and DK082863 (A.S.-F.L.); an interagency agreement with the National Institute of Diabetes and Digestive and Kidney Diseases: A-DK-3002-001 (L.M.G.-R.); and support from the intramural program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (M.G.G.). Additional funding for this study was provided by the Immunology Center (National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases, Center of Molecular Studies in Digestive and Liver Diseases: P30DK50306; and a National Institutes of Health Public Health Service Research grant: M01RR00040 to K.-M.C.), by the National Center for Advancing Translational Sciences, National Institutes of Health (UL1TR000058 to R.K.S.); and Clinical and Translational Science Awards grants: UL1TR000004 (N.A.T.), UL1TR001111 (M.W.F.), and UL1RR024986 (A.S.-F.L.). Additional support was provided by Gilead Sciences, Inc, and Roche Molecular Systems via a Cooperative Research And Development Agreement through the National Institute of Diabetes and Digestive and Kidney Diseases. NR 15 TC 11 Z9 11 U1 1 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 EI 1542-7714 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD JAN PY 2015 VL 13 IS 1 BP 183 EP 192 DI 10.1016/j.cgh.2014.06.028 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA AZ2BW UT WOS:000348040500032 PM 25010003 ER PT J AU Sodha, SV Heiman, K Gould, LH Bishop, R Iwamoto, M Swerdlow, DL Griffin, PM AF Sodha, S. V. Heiman, K. Gould, L. H. Bishop, R. Iwamoto, M. Swerdlow, D. L. Griffin, P. M. TI 0 National patterns of Escherichia coli O157 infections, USA, 1996-2011 SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Escherichia coli O157; haemolytic uraemic syndrome; HUS; Shiga toxin; surveillance ID RAW GROUND-BEEF; HEMOLYTIC-UREMIC SYNDROME; UNITED-STATES; INSPECTION SERVICE; FOOD SAFETY; SUSTAINED DECREASE; CATTLE; EPIDEMIOLOGY; SURVEILLANCE; CONSUMPTION AB US public health laboratories began reporting Escherichia coli O157 isolates to CDC in 1996. We describe temporal and geographical patterns of isolates reported from 1996 to 2011 and demographics of persons whose specimens yielded isolates. We calculated annual E. coli O157 isolation rates/100000 persons by patient's state of residence, county of residence, age, and sex using census data. The average annual isolation rate was 0.84. The average isolation rate in northern states (1.52) was higher than in southern states (0.43). Counties with 576% rural population had a lower isolation rate (0.67) than counties with 425%, 26-50%, and 51-75% rural populations (0.81, 0.92, and 0.81, respectively). The highest isolation rate (3.19) was in children aged 1-4 years. Infections were seasonal with 49% of isolates collected during July to September. Research into reasons for higher incidence in northern states and for seasonality could guide strategies to prevent illnesses. C1 [Sodha, S. V.; Heiman, K.; Gould, L. H.; Bishop, R.; Iwamoto, M.; Swerdlow, D. L.; Griffin, P. M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Heiman, K.] Atlanta Res & Educ Fdn, Decatur, GA USA. RP Sodha, SV (reprint author), 1600 Clifton Rd,MS A-04, Atlanta, GA 30333 USA. EM ssodha@cdc.gov NR 29 TC 7 Z9 7 U1 0 U2 6 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD JAN PY 2015 VL 143 IS 2 BP 267 EP 273 DI 10.1017/S0950268814000880 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CA0ZS UT WOS:000348642600006 PM 24731294 ER PT J AU Joseph, RH Haddad, FA Matthews, AL Maroufi, A Monroe, B Reynolds, M AF Joseph, R. H. Haddad, F. A. Matthews, A. L. Maroufi, A. Monroe, B. Reynolds, M. TI Erythema multiforme after orf virus infection: a report of two cases and literature review SO EPIDEMIOLOGY AND INFECTION LA English DT Review DE Immunology; orf; zoonoses ID IMMUNE; MANAGEMENT AB Orf virus has a worldwide distribution among sheep and goats. The hypersensitivity reaction erythema multiforme (EM) is a known complication of orf infection in humans; however, its occurrence is poorly understood and has not been extensively reviewed. We present two unrelated cases of orf-associated EM, and a review of the literature, highlighting important clinical, epidemiological and immunological aspects of this condition. Orf and its associated complications can occur in rural areas, as well as urban settings, where it is less well-known, through religious or cultural practices involving animal slaughter. Obtaining a history of animal exposures from patients with lesions suspicious for orf and secondary skin eruptions can guide diagnosis and identification of the inciting immune stimulus. Determining the pathophysiology and relative contribution of host and viral factors contributing to EM and other orf-associated hypersensitivity reactions could facilitate the identification of risk factors and inform treatment decisions. C1 [Joseph, R. H.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30341 USA. [Joseph, R. H.; Maroufi, A.] Cty San Diego Hlth & Human Serv Agcy, San Diego, CA USA. [Haddad, F. A.] Sharp Grossmont Hosp, Infect Dis Sect, La Mesa, CA USA. [Matthews, A. L.] Billings Clin, Billings, MT USA. [Monroe, B.; Reynolds, M.] Ctr Dis Control & Prevent, Natl Ctr Emerging Zoonot & Infect Dis, Poxvirus Branch, Atlanta, GA 30341 USA. RP Joseph, RH (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy NE,Mailstop F-76, Atlanta, GA 30341 USA. EM rjoseph@cdc.gov NR 30 TC 7 Z9 9 U1 3 U2 10 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD JAN PY 2015 VL 143 IS 2 BP 385 EP 390 DI 10.1017/S0950268814000879 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CA0ZS UT WOS:000348642600018 PM 24810660 ER PT J AU Yendell, SJ Taylor, J Biggerstaff, BJ Tabony, L Staples, JE Fischer, M AF Yendell, S. J. Taylor, J. Biggerstaff, B. J. Tabony, L. Staples, J. E. Fischer, M. TI Use of laboratory reports as predictors of West Nile virus disease cases, Texas, 2008-2012 SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE West Nile virus; public health surveillance; epidemiology; laboratory diagnoses ID DIAGNOSIS; SYSTEM AB We evaluated laboratory reports as early indicators of West Nile virus (WNV) disease cases in Texas. We compared WNV laboratory results in the National Electronic Disease Surveillance System Base System (NBS) to WNV disease cases reported to the state health department from 2008 to 2012. We calculated sensitivity and positive predictive value (PPV) of NBS reports, estimated the number of disease cases expected per laboratory report, and determined lead and lag times. The sensitivity and PPV of NBS laboratory reports were 86% and 77%, respectively. For every 10 positive laboratory reports, we expect 9.0 (95% confidence interval 8.9-9.2) reported disease cases. Laboratory reports preceded case reports with a lead time of 7 days. Electronic laboratory reports provided longer lead times than manually entered reports (P<0.01). NBS laboratory reports are useful estimates of future reported WNV disease cases and may provide timely information for planning public health interventions. C1 [Yendell, S. J.; Biggerstaff, B. J.; Staples, J. E.; Fischer, M.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Yendell, S. J.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Ft Collins, CO 80521 USA. [Taylor, J.; Tabony, L.] Texas Dept State Hlth Serv, Infect Dis Control Unit, Austin, TX USA. RP Fischer, M (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, 3156 Rampart Rd, Ft Collins, CO 80521 USA. EM mfischer@cdc.gov NR 16 TC 1 Z9 1 U1 0 U2 2 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 EI 1469-4409 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD JAN PY 2015 VL 143 IS 2 BP 419 EP 426 DI 10.1017/S0950268814000909 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CA0ZS UT WOS:000348642600024 PM 24762928 ER PT J AU Soe, MM Edwards, JR Sievert, DM Ricks, PM Magill, SS Fridkin, SK AF Soe, Minn M. Edwards, Jonathan R. Sievert, Dawn M. Ricks, Philip M. Magill, Shelley S. Fridkin, Scott K. TI Evaluating State-Specific Antibiotic Resistance Measures Derived from Central Line-Associated Bloodstream Infections, National Healthcare Safety Network, 2011 SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID ANTIMICROBIAL SURVEILLANCE PROGRAM; GRAM-NEGATIVE PATHOGENS; UNITED-STATES; KLEBSIELLA-PNEUMONIAE; SUSCEPTIBILITY; HOSPITALS; PREVALENCE; OUTCOMES; SPREAD AB DISCLOSURE. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention or the Agency for Toxic Substances and Diseases Registry. OBJECTIVE. Describe the impact of standardizing state-specific summary measures of antibiotic resistance that inform regional interventions to reduce transmission of resistant pathogens in healthcare settings. DESIGN. Analysis of public health surveillance data. METHODS. Central line-associated bloodstream infection (CLABSI) data from intensive care units (ICUs) of facilities reporting to the National Healthcare Safety Network in 2011 were analyzed. For CLABSI due to methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum cephalosporin (ESC)-nonsusceptible Klebsiella species, and carbapenem-nonsusceptible Klebsiella species, we computed 3 state-level summary measures of nonsusceptibility: crude percent nonsusceptible, model-based adjusted percent nonsusceptible, and crude infection incidence rate. RESULTS. Overall, 1,791 facilities reported CLABSIs from ICU patients. Of 1,618 S. aureus CLABSIs with methicillin-susceptibility test results, 791 (48.9%) were due to MRSA. Of 756 Klebsiella CLABSIs with ESC-susceptibility test results, 209 (27.7%) were due to ESC-nonsusceptible Klebsiella, and among 661 Klebsiella CLABSI with carbapenem susceptibility test results, 70 (10.6%) were due to carbapenem-nonsusceptible Klebsiella. All 3 state-specific measures demonstrated variability in magnitude by state. Adjusted measures, with few exceptions, were not appreciably different from crude values for any phenotypes. When linking values of crude and adjusted percent nonsusceptible by state, a state's absolute rank shifted slightly for MRSA in 5 instances and only once each for ESC-nonsusceptible and carbapenem-nonsusceptible Klebsiella species. Infection incidence measures correlated strongly with both percent nonsusceptibility measures. CONCLUSIONS. Crude state-level summary measures, based on existing NHSN CLABSI data, may suffice to assess geographic variability in antibiotic resistance. As additional variables related to antibiotic resistance become available, risk-adjusted summary measures are preferable. C1 [Soe, Minn M.; Edwards, Jonathan R.; Sievert, Dawn M.; Ricks, Philip M.; Magill, Shelley S.; Fridkin, Scott K.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA USA. RP Soe, MM (reprint author), CDC, MS A-24,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM msoe@cdc.gov FU Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention FX Financial support. The NHSN surveillance system is supported by the Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention. NR 33 TC 1 Z9 1 U1 0 U2 5 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0899-823X EI 1559-6834 J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD JAN PY 2015 VL 36 IS 1 BP 54 EP 64 DI 10.1017/ice.2014.11 PG 11 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA CA0EO UT WOS:000348588800009 PM 25627762 ER PT J AU Powers, C Fan, B Borrud, LG Looker, AC Shepherd, JA AF Powers, Cassidy Fan, Bo Borrud, Lori G. Looker, Anne C. Shepherd, John A. TI Long-Term Precision of Dual-Energy X-ray Absorptiometry Body Composition Measurements and Association With Their Covariates SO JOURNAL OF CLINICAL DENSITOMETRY LA English DT Article DE Body composition; bone mineral density; Hologic; precision; whole body ID BONE-MINERAL DENSITY; DXA; REPRODUCIBILITY; CHILDREN; SPINE; WOMEN; LUNAR AB Few studies have described the long-term repeatability of dual-energy X-ray absorptiometry scans. Even fewer studies have been performed with enough participants to identify possible precision covariates such as sex, age, and body mass index (BMI). Our objective was to investigate the long-term repeatability of both total and subregional body composition measurements and their associations with covariates in a large sample. Two valid whole-body dual-energy X-ray absorptiometry scans were available for 609 participants in the National Health and Nutrition Examination Survey 2000-2002. Participants with scan-quality issues were excluded. Participants varied in race and ethnicity, sex, age (mean 38.8 +/- 17.5; range 16-69 yr), and BMI (mean, 26.9 +/- 5.2; range 14.1-43.5 kg/m(2)). The length of time between scans ranged from 3 to 51 days (mean, 18.7 +/- 8.4). Precision error estimates for total body measures (bone mineral density, bone mineral content, lean mass, total mass, fat mass, and percent body fat) were calculated as root mean square percent coefficients of variation and standard deviations. The average root mean square percent coefficients of variation and root mean square standard deviations of the precision error for total body variables were 1.12 and 0.01 g/cm(2) for bone mineral density, 1.14 and 27.3 g for bone mineral content, 1.97 and 505 g for fat mass, 1.46 and 760 g for lean mass, 1.10 and 858 g for total mass, and 1.80 and 0.59 for percent body fat. In general, only fat and lean masses were impacted by participant and scan qualities (obesity category, sex, the magnitude of the body composition variables, and time between scans). We conclude that long-term precision error values are impacted by BMI, and sex. Our long-term precision error estimates may be more suitable than short-term precision for calculating least significant change and monitoring time intervals. C1 [Powers, Cassidy; Fan, Bo; Shepherd, John A.] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA. [Borrud, Lori G.; Looker, Anne C.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. RP Shepherd, JA (reprint author), Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA. EM john.shepherd@ucsf.edu FU Centers for Disease Control and Prevention [200-2005-11219] FX The whole-body scans for the study were provided through contract no. 200-2005-11219 with the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 21 TC 1 Z9 1 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1094-6950 EI 1559-0747 J9 J CLIN DENSITOM JI J. Clin. Densitom. PD JAN-MAR PY 2015 VL 18 IS 1 BP 76 EP 85 DI 10.1016/j.jocd.2013.09.010 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA CA5TI UT WOS:000348970300014 PM 24200863 ER PT J AU Kaneshiro, ES Marciano-Cabral, F Moura, H AF Kaneshiro, Edna S. Marciano-Cabral, Francine Moura, Hercules TI Govinda S. Visvesvara: A Tribute INTRODUCTION SO JOURNAL OF EUKARYOTIC MICROBIOLOGY LA English DT Editorial Material C1 [Kaneshiro, Edna S.] Univ Cincinnati, Dept Biol Sci, Cincinnati, OH 45221 USA. [Marciano-Cabral, Francine] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Sch Med, Richmond, VA 23298 USA. [Moura, Hercules] Ctr Dis Control & Prevent, Clin Chem Branch, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA. RP Kaneshiro, ES (reprint author), Univ Cincinnati, Dept Biol Sci, Cincinnati, OH 45221 USA. EM edna.kaneshiro@uc.edu NR 0 TC 0 Z9 0 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1066-5234 EI 1550-7408 J9 J EUKARYOT MICROBIOL JI J. Eukaryot. Microbiol. PD JAN-FEB PY 2015 VL 62 IS 1 BP 1 EP 2 DI 10.1111/jeu.12143 PG 2 WC Microbiology SC Microbiology GA CA2DB UT WOS:000348718000001 PM 25040661 ER PT J AU Moura, H Izquierdo, F Woolfitt, AR Wagner, G Pinto, T del Aguila, C Barr, JR AF Moura, Hercules Izquierdo, Fernando Woolfitt, Adrian R. Wagner, Glauber Pinto, Tatiana del Aguila, Carmen Barr, John R. TI Detection of Biomarkers of Pathogenic Naegleria fowleri Through Mass Spectrometry and Proteomics SO JOURNAL OF EUKARYOTIC MICROBIOLOGY LA English DT Article DE Free-living amoebae; matrix-assisted laser-desorption-ionization-time-of-flight mass spectrometry; Naegleria; protein fingerprints ID DESORPTION IONIZATION-TIME; PRIMARY AMEBIC MENINGOENCEPHALITIS; CLINICAL MICROBIOLOGY; COXIELLA-BURNETII; MALDI; IDENTIFICATION; DIFFERENTIATION; BACTERIA; GENOME; STRAIN AB Emerging methods based on mass spectrometry (MS) can be used in the rapid identification of microorganisms. Thus far, these practical and rapidly evolving methods have mainly been applied to characterize prokaryotes. We applied matrix-assisted laser-desorption-ionization-time-of-flight mass spectrometry MALDI-TOF MS in the analysis of whole cells of 18 N. fowleri isolates belonging to three genotypes. Fourteen originated from the cerebrospinal fluid or brain tissue of primary amoebic meningoencephalitis patients and four originated from water samples of hot springs, rivers, lakes or municipal water supplies. Whole Naegleria trophozoites grown in axenic cultures were washed and mixed with MALDI matrix. Mass spectra were acquired with a 4700 TOF-TOF instrument. MALDI-TOF MS yielded consistent patterns for all isolates examined. Using a combination of novel data processing methods for visual peak comparison, statistical analysis and proteomics database searching we were able to detect several biomarkers that can differentiate all species and isolates studied, along with common biomarkers for all N. fowleri isolates. Naegleria fowleri could be easily separated from other species within the genus Naegleria. A number of peaks detected were tentatively identified. MALDI-TOF MS fingerprinting is a rapid, reproducible, high-throughput alternative method for identifying Naegleria isolates. This method has potential for studying eukaryotic agents. C1 [Moura, Hercules; Woolfitt, Adrian R.; Barr, John R.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Izquierdo, Fernando; del Aguila, Carmen] Univ San Pablo CEU, Fac Farm, Madrid, Spain. [Wagner, Glauber] Univ Oeste Santa Catarina, Lab Doencas Infecciosas & Parasitarias, Joacaba, Brazil. [Pinto, Tatiana] Univ Fed Rio de Janeiro, Inst Microbiol Paulo de Goes, Rio De Janeiro, Brazil. RP Barr, JR (reprint author), Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, MS F-50,4770 Buford Hwy NE, Atlanta, GA 30341 USA. EM jbarr@cdc.gov RI Wagner, Glauber/B-2369-2013; del Aguila, Carmen/A-6063-2016 OI Wagner, Glauber/0000-0001-5003-6595; del Aguila, Carmen/0000-0003-0063-7899 NR 37 TC 4 Z9 4 U1 3 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1066-5234 EI 1550-7408 J9 J EUKARYOT MICROBIOL JI J. Eukaryot. Microbiol. PD JAN-FEB PY 2015 VL 62 IS 1 BP 12 EP 20 DI 10.1111/jeu.12178 PG 9 WC Microbiology SC Microbiology GA CA2DB UT WOS:000348718000003 PM 25231600 ER PT J AU Ma, JB Cai, JZ Ma, JW Feng, YY Xiao, LH AF Ma, Jingbo Cai, Jinzhong Ma, Jiawen Feng, Yaoyu Xiao, Lihua TI Enterocytozoon bieneusi Genotypes in Yaks (Bos grunniens) and Their Public Health Potential SO JOURNAL OF EUKARYOTIC MICROBIOLOGY LA English DT Article DE Epidemiology; genotype; ITS; zoonotic ID EASTERN UNITED-STATES; DAIRY-CATTLE; 1ST DETECTION; MOLECULAR CHARACTERIZATION; GIARDIA-DUODENALIS; MICROSPORIDIOSIS; CRYPTOSPORIDIUM; PREVALENCE; INFECTION; SEQUENCE AB Enterocytozoon bieneusi, the most frequently diagnosed microsporidian species in humans, is also identified in a wide range of animals. To date, few data are available on E. bieneusi in yaks (Bos grunniens). In this study, we examined the occurrence and genotype identity of E. bieneusi in yaks in four counties in Qinghai Province of China. Of 327 fecal specimens examined by nested PCR analysis of the ribosomal internal transcribed spacer, 23 (7.0%) were E. bieneusi-positive. DNA sequence analysis of the PCR products revealed the presence of five distinct genotypes: three Group 2 genotypes previously reported in cattle as well as humans (BEB4, I and J) and two novel genotypes (CHN11 and CHN12) belonging to the large zoonotic group (Group 1). Data of the study suggest that these animals could be potential reservoirs for human E. bieneusi infection. C1 [Ma, Jingbo; Ma, Jiawen; Feng, Yaoyu] E China Univ Sci & Technol, Sch Resources & Environm Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. [Cai, Jinzhong] Qinghai Acad Vet Med & Anim Sci, Xining 810016, Peoples R China. [Xiao, Lihua] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA. RP Feng, YY (reprint author), E China Univ Sci & Technol, Sch Resources & Environm Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. EM yyfeng@ecust.edu.cn; lxiao@cdc.gov RI Feng, Yaoyu/B-3076-2014; Xiao, Lihua/B-1704-2013 OI Xiao, Lihua/0000-0001-8532-2727 FU National Natural Science Foundation of China [31110103901, 31229005]; National Special Fund for State Key Laboratory of Bioreactor Engineering, China [2060204]; Fundamental Research Funds for the Central Universities, China FX This study was supported by National Natural Science Foundation of China (31110103901 and 31229005), National Special Fund for State Key Laboratory of Bioreactor Engineering, China (no. 2060204), and Fundamental Research Funds for the Central Universities, China. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 33 TC 7 Z9 7 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1066-5234 EI 1550-7408 J9 J EUKARYOT MICROBIOL JI J. Eukaryot. Microbiol. PD JAN-FEB PY 2015 VL 62 IS 1 BP 21 EP 25 DI 10.1111/jeu.12141 PG 5 WC Microbiology SC Microbiology GA CA2DB UT WOS:000348718000004 PM 25040451 ER PT J AU Fajardo, GC Posid, J Papagiotas, S Lowe, L AF Fajardo, Geroncio C. Posid, Joseph Papagiotas, Stephen Lowe, Luis TI Comparing Electronic News Media Reports of Potential Bioterrorism-Related Incidents Involving Unknown White Powder to Reports Received by the United States Centers for Disease Control and Prevention and the Federal Bureau of Investigation: USA, 2009-2011 SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE forensic science; electronic news media; potential bioterrorism; unknown "white powder"; law enforcement; public health ID ANTHRAX AB There have been periodic electronic news media reports of potential bioterrorism-related incidents involving unknown substances (often referred to as white powder) since the 2001 intentional dissemination of Bacillus anthracis through the U.S. Postal System. This study reviewed the number of unknown white powder incidents reported online by the electronic news media and compared them with unknown white powder incidents reported to the U.S. Centers for Disease Control and Prevention (CDC) and the U.S. Federal Bureau of Investigation (FBI) during a 2-year period from June 1, 2009 and May 31, 2011. Results identified 297 electronic news media reports, 538 CDC reports, and 384 FBI reports of unknown white powder. This study showed different unknown white powder incidents captured by each of the three sources. However, the authors could not determine the public health implications of this discordance. C1 [Fajardo, Geroncio C.; Papagiotas, Stephen] US Ctr Dis Control & Prevent, Emergency Preparedness & Response Branch EPRB, Div Preparedness & Emerging Infect DPEI, Atlanta, GA 30333 USA. [Posid, Joseph] US Ctr Dis Control & Prevent, Off Director OD, Div Preparedness & Emerging Infect DPEI, Atlanta, GA 30333 USA. [Lowe, Luis] US Ctr Dis Control & Prevent, Lab Preparedness & Response Branch LPRB, Div Preparedness & Emerging Infect DPEI, Atlanta, GA 30333 USA. RP Fajardo, GC (reprint author), US Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS C-18, Atlanta, GA 30333 USA. EM gfajardo@cdc.gov FU Intramural CDC HHS [CC999999] NR 19 TC 0 Z9 0 U1 1 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-1198 EI 1556-4029 J9 J FORENSIC SCI JI J. Forensic Sci. PD JAN PY 2015 VL 60 SU 1 BP S76 EP S82 DI 10.1111/1556-4029.12608 PG 7 WC Medicine, Legal SC Legal Medicine GA AZ9YC UT WOS:000348569500009 PM 25420771 ER PT J AU Kearns, MC Reidy, DE Valle, LA AF Kearns, Megan C. Reidy, Dennis E. Valle, Linda Anne TI The Role of Alcohol Policies in Preventing Intimate Partner Violence: A Review of the Literature SO JOURNAL OF STUDIES ON ALCOHOL AND DRUGS LA English DT Review ID OUTLET DENSITY; DOMESTIC VIOLENCE; ASSAULTIVE VIOLENCE; GEOSPATIAL ANALYSIS; SPATIAL DYNAMICS; DRINKING CONTEXT; RETAIL SHOPS; US CITIES; AVAILABILITY; CONSUMPTION AB Objective: This article summarizes existing research on the relationship between alcohol policies and intimate partner violence (IPV). Because alcohol use represents an important risk factor for IPV, interventions and policies aimed at decreasing problem drinking may also lead to reductions in IPV. Method: Electronic databases were searched to identify relevant peer-reviewed journal articles on alcohol policies and IPV, as well as reference sections of appropriate articles. Only policies that have been studied specifically for their impact on IPV were included. Results: Three alcohol policy areas (outlet density, hours and days of sale, and pricing/taxation) have been studied in relation to IPV outcomes. Research on outlet density has the most consistent findings, with most studies indicating that higher densities of alcohol outlets are associated with higher rates of IPV. Fewer studies have been conducted on pricing policies and policies restricting hours/days of sale, with most studies suggesting no impact on IPV rates. Conclusions: A higher density of alcohol outlets appears to be associated with greater rates of IPV. However, there is limited evidence suggesting that alcohol pricing policies and restrictions on hours and days of sale are associated with IPV outcomes. Knowledge about the impact of alcohol-related policies on IPV and violence in general is limited by several significant research gaps. Additional research is needed to assess the impact of alcohol policies on IPV and other forms of violence. C1 [Kearns, Megan C.; Reidy, Dennis E.; Valle, Linda Anne] Ctr Dis Control & Prevent, Div Violence Prevent, Atlanta, GA 30341 USA. RP Kearns, MC (reprint author), Ctr Dis Control & Prevent, Div Violence Prevent, 4770 Buford Highway NE,MS F-64, Atlanta, GA 30341 USA. EM wti8@cdc.gov FU Intramural CDC HHS [CC999999] NR 91 TC 3 Z9 3 U1 3 U2 16 PU ALCOHOL RES DOCUMENTATION INC CENT ALCOHOL STUD RUTGERS UNIV PI PISCATAWAY PA C/O DEIRDRE ENGLISH, 607 ALLISON RD, PISCATAWAY, NJ 08854-8001 USA SN 1937-1888 EI 1938-4114 J9 J STUD ALCOHOL DRUGS JI J. Stud. Alcohol Drugs PD JAN PY 2015 VL 76 IS 1 BP 21 EP 30 PG 10 WC Substance Abuse; Psychology SC Substance Abuse; Psychology GA CA0RX UT WOS:000348625300002 PM 25486390 ER PT J AU Chapman, DP Liu, Y McKnight-Eily, LR Croft, JB Holt, JB Balkin, TJ Giles, WH AF Chapman, Daniel P. Liu, Yong McKnight-Eily, Lela R. Croft, Janet B. Holt, James B. Balkin, Thomas J. Giles, Wayne H. TI Daily Insufficient Sleep and Active Duty Status SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; U.S. MILITARY VETERANS; SERVICE MEMBERS; US ADULTS; COMBAT; PERSONNEL; SYMPTOMS; ASSOCIATION; DEPLOYMENT; BEHAVIORS AB Objective: We assessed the relationship between active duty status and daily insufficient sleep in a telephone survey. Methods: U.S. military service status (recent defined as past 12 months and past defined as >12 months ago) and daily insufficient sleep in the past 30 days were assessed among 566,861 adults aged 18 to 64 years and 271,202 adults aged >= 65 years in the 2009 to 2010 Behavioral Risk Factor Surveillance System surveys. Results: Among ages 18 to 64 years, 1.1% reported recent active duty and 7.1% had past service; among ages >= 65 years, 0.6% reported recent and 24.6% had past service. Among ages 18 to 64 years, prevalence of daily insufficient sleep was 13.7% among those reporting recent duty, 12.6% for those with past service, and 11.2% for those with no service. Insufficient sleep did not vary significantly with active duty status among ages >= 65 years. After adjustment for sociodemographic characteristics, health behaviors, and frequent mental distress in multivariate logistic regression models, respondents aged 18 to 64 years with recent active duty were 34% more likely and those with past service were 23% more likely to report daily insufficient sleep than those with no service (p < 0.05, both). Conclusions: Adults with either recent or past active duty have a greater risk for daily insufficient sleep. C1 [Chapman, Daniel P.; Liu, Yong; McKnight-Eily, Lela R.; Croft, Janet B.; Holt, James B.; Giles, Wayne H.] Natl Ctr Chron Dis Prevent & Hlth Promot, Ctr Dis Control & Prevent, Div Populat Hlth, Epidemiol & Surveillance Branch, Atlanta, GA 30341 USA. [Balkin, Thomas J.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Chapman, DP (reprint author), Natl Ctr Chron Dis Prevent & Hlth Promot, Ctr Dis Control & Prevent, Div Populat Hlth, Epidemiol & Surveillance Branch, 4770 Buford Highway Northeast,Mailstop K-78, Atlanta, GA 30341 USA. NR 39 TC 0 Z9 0 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD JAN PY 2015 VL 180 IS 1 BP 68 EP 76 DI 10.7205/MILMED-D-14-00158 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA CA7MM UT WOS:000349101400028 PM 25562860 ER PT J AU Gilbert, A Greenberg, L Moran, D Alvarez, D Alvarado, M Garcia, DL Peruski, L AF Gilbert, Amy Greenberg, Lauren Moran, David Alvarez, Danilo Alvarado, Marlon Garcia, Daniel L. Peruski, Leonard TI Antibody response of cattle to vaccination with commercial modified live rabies vaccines in Guatemala SO PREVENTIVE VETERINARY MEDICINE LA English DT Article DE Rabies; Cattle; Modified live vaccine; Vampire bats; Rabies virus neutralizing antibody ID GLYCOPROTEIN; DISEASE AB Vampire bat rabies is a public and animal health concern throughout Latin America. As part of an ecological study of vampire bat depredation on cattle in southern Guatemala, we conducted a vaccine seroconversion study among three dairy farms. The main objectives of this cross sectional and cohort study were to understand factors associated with bat bites among cattle, to determine whether unvaccinated cattle had evidence of rabies virus exposure and evaluate whether exposure was related to bat bite prevalence, and to assess whether cattle demonstrate adequate seroconversion to two commercial vaccines used in Guatemala. In 2012, baseline blood samples were collected immediately prior to intramuscular inoculation of cattle with one of two modified live rabies vaccines. Post vaccination blood samples were collected 13 and 393 days later. Sera were tested for rabies virus neutralizing antibodies (rVNA) by the rapid fluorescent focus inhibition test (REFIT). Across two years of study, 36% (254/702) of inspected cattle presented gross evidence of vampire bat bites. Individual cattle with a bat bite in 2012 were more likely have a bat bite in 2013. Prior to vaccination, 12% (42/350) of cattle sera demonstrated rVNA, but bite status in 2012 was not associated with presence of rVNA. Vaccine brand was the only factor associated with adequate rVNA response of cattle by day 13. However, vaccine brand and rVNA status at day 13 were associated with an adequate rVNA titer on day 393, with animals demonstrating an adequate titer at day 13 more likely to have an adequate titer at day 393. Our findings support stable levels of vampire bat depredation and evidence of rVNA in unvaccinated cattle. Brand of vaccine may be an important consideration impacting adequate rVNA response and long-term maintenance of rVNA in cattle. Further, the results demonstrate that initial response to vaccination is associated with rVNA status over one year following vaccination. Published by Elsevier B.V. C1 [Gilbert, Amy] USDA, APHIS Wildlife Serv, Natl Wildlife Res Ctr, Ft Collins, CO 80521 USA. [Greenberg, Lauren] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Atlanta, GA USA. [Moran, David; Alvarez, Danilo] Univ Valle Guatemala, Ctr Estudios Salud, Guatemala City, Guatemala. [Alvarado, Marlon] Minist Agr Ganaderia & Alimentac, Guatemala City, Guatemala. [Garcia, Daniel L.; Peruski, Leonard] Ctr Dis Control & Prevent, Reg Off Cent Amer & Panama, Guatemala City, Guatemala. RP Gilbert, A (reprint author), USDA, APHIS Wildlife Serv, Natl Wildlife Res Ctr, 4101 La Porte Ave, Ft Collins, CO 80521 USA. EM Amy.T.Gilbert@aphis.usda.gov; foe2@cdc.gov; dmoran@CES.UVG.EDU.GT; dalvarez@CES.UVG.EDU.GT; int7@cdc.gov; cznl@cdc.gov FU Global Disease Detection Program of the Centers for Disease Control and Prevention FX This study would not have been possible without cooperation from the landowners, and the authors express thanks to the Facultad de Medicina Veterinaria y Zoontecnica of the Universidad de San Carlos (FMVZ-USAC), Milton Nelson, and Moises Nelson. The authors appreciate invaluable technical assistance from technicians and veterinarians at the Ministerio de Agricultura, Ganaderia y Alimentacion (MAGA); Ramon Medrano, Esteban Fuentes, Ana Barrios, Jose Adan Real, and Maria Renee Lopez of the Centro de Estudios en Salud at the Universidad del Valle (UVG-CES); Jennifer Riley of Tufts University; and Fredy Gonzalez and veterinary students from the Universidad de San Carlos. Jose Galvez, Brenda Martinez, and Marco Quan at the Centers for Disease Control - Central American Region (CDC-CAR) provided excellent logistic assistance. This study was supported by Technical Support Corps funds from the Global Disease Detection Program of the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of their institutions, respectively. NR 28 TC 2 Z9 2 U1 1 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-5877 EI 1873-1716 J9 PREV VET MED JI Prev. Vet. Med. PD JAN 1 PY 2015 VL 118 IS 1 BP 36 EP 44 DI 10.1016/j.prevetmed.2014.10.011 PG 9 WC Veterinary Sciences SC Veterinary Sciences GA CA5OS UT WOS:000348958300005 PM 25466762 ER PT J AU Pitman, JP Wilkinson, R Liu, Y von Finckenstein, B Sibinga, CTS Lowrance, DW Marfin, AA Postma, MJ Mataranyika, M Basavaraju, SV AF Pitman, John P. Wilkinson, Robert Liu, Yang von Finckenstein, Bjorn Sibinga, Cees Th. Smit Lowrance, David W. Marfin, Anthony A. Postma, Maarten J. Mataranyika, Mary Basavaraju, Sridhar V. TI Blood Component Use in a Sub-Saharan African Country: Results of a 4-Year Evaluation of Diagnoses Associated With Transfusion Orders in Namibia SO TRANSFUSION MEDICINE REVIEWS LA English DT Review DE Namibia; Blood safety; Blood transfusion; PEPFAR ID I TRAUMA CENTER; EMERGENCY OBSTETRIC CARE; CELL TRANSFUSION; TRANEXAMIC ACID; CRITICALLY-ILL; AUDIT; EDUCATION; PRODUCTS; SERVICES; SURGERY AB National blood use patterns in sub-Saharan Africa are poorly described. Although malaria and maternal hemorrhage remain important drivers of blood demand across Africa, economic growth and changes in malaria, HIV/AIDS, and noncommunicable disease epidemiology may contribute to changes in blood demand. We evaluated indications for blood use in Namibia, a country in southern Africa, using a nationally representative sample and discuss implications for the region. Clinical and demographic data related to the issuance of blood component units in Namibia were reviewed for a 4-year period (August 1, 2007-July 31, 2011). Variables included blood component type, recipient age and sex, and diagnosis. Diagnoses reported by clinicians were reclassified into International Statistical Classification of Diseases, 10th Revision categories. Multiple imputation methods were used to complete a data set missing age, sex or diagnosis data. Descriptive analyses were conducted to describe indications for transfusions and use of red blood cells (RBCs), platelets, and plasma. A total of 39 313 records accounting for 91 207 blood component units were analyzed. The median age of Namibian transfusion recipients was 45 years (SD, +/- 19). A total of 78 660 RBC units were issued in Namibia during the study period. Red blood cells transfused for "unspecified anemia" accounted for the single largest category of blood issued (24 798 units). Of the overall total, 38.9% were for diseases of the blood and blood-forming organs (D50-D89). Infectious disease (A00-B99), pregnancy (O00-O99), and gastrointestinal (K20-K93) accounted for 14.8%, 11.1%, and 6.1% of RBC units issued, respectively. Although a specific diagnosis of malaria accounted for only 2.7% of pediatric transfusions, an unknown number of additional transfusions for malaria may have been categorized by requesting physicians as unspecified anemia and counted under diseases of blood forming organs. During the study period, 9751 units of fresh-frozen plasma were issued. Nearly one-quarter of these units (23.1%) were issued for gastrointestinal (K20-K93) diagnoses. Malignant neoplasms (C00-C97) accounted for 38.1% of 2978 platelet units issued. Blood use in Namibia reflects changes in the health care system due to economic development, improvement in HIV/AIDS and malaria epidemiology, high rates of health care facility-based childbirth, and access to noncommunicable disease treatment. However, better documentation of the indications for transfusion is needed to confirm these observations. Changing patterns of health care will result in changing demands for blood components. Improved methods to evaluate blood use patterns in sub-Saharan Africa may help set realistic national blood collection goals. Published by Elsevier Inc C1 [Pitman, John P.; Liu, Yang; Marfin, Anthony A.; Basavaraju, Sridhar V.] US Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA 30333 USA. [Pitman, John P.; Postma, Maarten J.] Univ Groningen, Univ Med Ctr Groningen, Inst Sci Hlth Aging & Hlth caRE SHARE, NL-9713 AV Groningen, Netherlands. [Wilkinson, Robert; von Finckenstein, Bjorn] Blood Transfus Serv Namibia, Windhoek, Namibia. [Sibinga, Cees Th. Smit] ID Consulting Int Dev Transfus Med, Groningen, Netherlands. [Lowrance, David W.] US Ctrs Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Windhoek, Namibia. [Postma, Maarten J.] Univ Groningen, Dept Pharm, Unit PharmacoEpidemiol & PharmacoEcon PE2, Groningen, Netherlands. [Mataranyika, Mary] Namibia Minist Hlth & Social Serv, Directorate Clin Support Serv, Windhoek, Namibia. RP Pitman, JP (reprint author), US Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, HIV Prevent Branch, 1600 Clifton Rd NE,MS E-04, Atlanta, GA 30333 USA. EM cgx5@cdc.gov OI Pitman, John/0000-0001-5983-7241 FU President's Emergency Plan for AIDS Relief through the Centers for Disease Control and Prevention FX This project has been supported by the President's Emergency Plan for AIDS Relief through the Centers for Disease Control and Prevention. NR 57 TC 8 Z9 8 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0887-7963 EI 1532-9496 J9 TRANSFUS MED REV JI Transf. Med. Rev. PD JAN PY 2015 VL 29 IS 1 BP 45 EP 51 DI 10.1016/j.tmrv.2014.11.003 PG 7 WC Hematology SC Hematology GA CA5TV UT WOS:000348971600006 PM 25573416 ER PT J AU Ahluwalia, N Herrick, K AF Ahluwalia, Namanjeet Herrick, Kirsten TI Caffeine Intake from Food and Beverage Sources and Trends among Children and Adolescents in the United States: Review of National Quantitative Studies from 1999 to 2011 SO Advances in Nutrition LA English DT Article DE caffeine intake; dietary sources; children; adolescents; trends ID ENERGY DRINKS; CONSUMPTION; US; HEALTH AB There is increasing concern about potential adverse effects of caffeine in children. Our understanding of caffeine intake relies on studies dating to the late 1990s. This article synthesizes information from national studies since then to describe caffeine consumption, its association with sociodemographic factors, key dietary sources including caffeine-containing energy drinks (CCEDs), and trends in caffeine intake and sources among US children. Findings from the Kanter Worldpanel (KWP) Beverage Consumption Panel and the NHANES showed that caffeine consumption prevalence was generally consistent across studies and over time; more than one-half of 2- to 5-y-olds and similar to 75% of older children (>5 y) consumed caffeine. The usual intakes of caffeine were 25 and 50 mg/d for children and adolescents aged 2-11 and 12-17 y, respectively (NHANES 2007-2010). Caffeine consumption correlated with age and was higher in non-Hispanic white children. The key sources of caffeine were soda and tea as well as flavored dairy (for children aged <12 y) and coffee (for those aged >= 12 y). The frequency of CCED use varied (2-30%) depending on study setting, methods, and demographic characteristics. A statistically significant but small decline in caffeine intake was noted in children overall during the 10- to 12-y period examined; intakes remained stable among older children (>= 12 y). A significant increasing trend in CCED and coffee consumption and a decline in soda intake were noted (1999-2010). In 2009-2010, 10% of 12-to 19-y-olds and 10-25% of caffeine consumers (aged 12-19 y) had intakes exceeding Canadian maximal guidelines. Continued monitoring can help better understand changes in caffeine consumption patterns of youth. C1 [Ahluwalia, Namanjeet; Herrick, Kirsten] Natl Ctr Hlth Stat, Ctr Dis Control & Prevent, Div Hlth & Nutr Examinat Surveys, Hyattsville, MD 20782 USA. RP Ahluwalia, N (reprint author), Natl Ctr Hlth Stat, Ctr Dis Control & Prevent, Div Hlth & Nutr Examinat Surveys, Hyattsville, MD 20782 USA. EM naman.ahluwalia@cdc.gov FU American Society for Nutntion (ASN); Office of Dietary Supplements, NIH FX The article is a review of the symposium "Energy Drinks: Current Knowledge and Critical Research Gaps" held 26 April 2014 at the ASN Scientific Sessions and Annual Meeting at Experimental Biology 2014 in San Diego, CA. The symposium was sponsored by the American Society for Nutntion (ASN) and supported by the Office of Dietary Supplements, NIH. NR 43 TC 2 Z9 2 U1 2 U2 32 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 2161-8313 EI 2156-5376 J9 ADV NUTR JI Adv. Nutr. PD JAN PY 2015 VL 6 IS 1 BP 102 EP 111 DI 10.3945/an.114.007401 PG 10 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AZ8SG UT WOS:000348484300011 PM 25593149 ER PT J AU Pringle, K Lopman, B Vega, E Vinje, J Parashar, UD Hall, AJ AF Pringle, Kimberly Lopman, Benjamin Vega, Everardo Vinje, Jan Parashar, Umesh D. Hall, Aron J. TI Noroviruses: epidemiology, immunity and prospects for prevention SO Future Microbiology LA English DT Review DE Caliciviridae; GII; 4; herd immunity; norovirus; vaccine ID VIRUS-LIKE PARTICLES; BLOOD GROUP ANTIGENS; INFECTIOUS NONBACTERIAL GASTROENTERITIS; LINKED-IMMUNOSORBENT-ASSAY; EXPRESSED NORWALK VIRUS; GII.4 SYDNEY NOROVIRUS; UNITED-STATES; MOLECULAR EPIDEMIOLOGY; VIRAL LOAD; HUMAN CALICIVIRUSES AB In recent years, noroviruses have become recognized as an important cause of both sporadic and epidemic acute gastroenteritis (AGE), largely due to the improved availability of broadly reactive real-time RT-PCR (TaqMan-based RT-PCR) assays. While there is substantial diversity among noroviruses, one specific genotype, GII.4, is the most common etiology in sporadic and epidemic AGE. Outbreaks of norovirus AGE most commonly occur in healthcare facilities and restaurants and result in significant morbidity and mortality and substantial healthcare costs. Norovirus vaccine development is progressing, and Phase I and II human trials have shown proof-of-principle that norovirus vaccines can reduce illness and infection. C1 [Pringle, Kimberly; Lopman, Benjamin; Vega, Everardo; Vinje, Jan; Parashar, Umesh D.; Hall, Aron J.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Pringle, Kimberly] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. RP Pringle, K (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,Mailstop A-34, Atlanta, GA 30333 USA. EM wot9@cdc.gov NR 153 TC 20 Z9 22 U1 7 U2 38 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 1746-0913 EI 1746-0921 J9 FUTURE MICROBIOL JI Future Microbiol. PY 2015 VL 10 IS 1 BP 53 EP 67 DI 10.2217/fmb.14.102 PG 15 WC Microbiology SC Microbiology GA AZ8JO UT WOS:000348461900007 PM 25598337 ER PT J AU Ramlal, RT Tembo, M King, CC Ellington, S Soko, A Chigwenembe, M Chasela, C Jamieson, DJ van der Horst, C Bentley, M Adair, L AF Ramlal, Roshan T. Tembo, Martin King, Caroline C. Ellington, Sascha Soko, Alice Chigwenembe, Maggie Chasela, Charles Jamieson, Denise J. van der Horst, Charles Bentley, Margaret Adair, Linda CA BAN Study Team TI Dietary Patterns and Maternal Anthropometry in HIV-Infected, Pregnant Malawian Women SO NUTRIENTS LA English DT Article DE maternal diet; nutrition; pregnancy; HIV; anthropometry; Malawi; cluster analysis ID BODY-COMPOSITION; CLUSTER-ANALYSIS; EATING PATTERNS; FOOD PATTERNS; TRANSMISSION; ASSOCIATION; PREDICTORS; PREVENTION; NUTRIENT; ADULTS AB Diet is a modifiable factor that can contribute to the health of pregnant women. In a sample of 577 HIV-positive pregnant women who completed baseline interviews for the Breastfeeding, Antiretrovirals, and Nutrition Study in Lilongwe, Malawi, cluster analysis was used to derive dietary patterns. Multiple regression analysis was used to identify associations between the dietary patterns and mid-upper arm circumference (MUAC), arm muscle area (AMA), arm fat area (AFA), and hemoglobin at baseline. Three key dietary patterns were identified: animal-based, plant-based, and grain-based. Women with relatively greater wealth were more likely to consume the animal-based diet, which had the highest intake of energy, protein, and fat and was associated with higher hemoglobin levels compared to the other diets. Women with the lowest wealth were more likely to consume the grain-based diet with the lowest intake of energy, protein, fat, and iron and were more likely to have lower AFA than women on the animal-based and plant-based diets, but higher AMA compared to women on the animal-based diet. Pregnant, HIV-infected women in Malawi could benefit from nutritional support to ensure greater nutrient diversity during pregnancy, when women face increased nutrient demands to support fetal growth and development. C1 [Ramlal, Roshan T.; van der Horst, Charles; Bentley, Margaret; Adair, Linda] Univ N Carolina, Chapel Hill, NC 27599 USA. [Tembo, Martin; Soko, Alice; Chigwenembe, Maggie; Chasela, Charles] Tidziwe Ctr, UNC Project Malawi, Lilongwe, Malawi. [King, Caroline C.; Ellington, Sascha; Jamieson, Denise J.] US Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Chasela, Charles] Univ Witwatersrand, Div Epidemiol & Biostat, Fac Hlth Sci, ZA-2193 Johannesburg, South Africa. RP Ramlal, RT (reprint author), Univ N Carolina, Chapel Hill, NC 27599 USA. EM roshan.m.thomas@gmail.com; martintembo@gmail.com; ccking@cdc.gov; sellington@cdc.gov; asoko@unclilongwe.org; mchigwenembe@unclilongwe.org; Charles.Chasela@wits.ac.za; djamieson@cdc.gov; charles_vanderhorst@med.unc.edu; pbentley@unc.edu; linda_adair@unc.edu FU National Institute of Allergy and Infectious Diseases at the National Institutes of Health [R03AI100694-A1]; Prevention Research Centers Special Interest Project of the Centers for Disease Control and Prevention [SIP 13-01 U48-CCU409660-09, SIP 26-04 U48-DP000059-01, SIP 22-09 U48-DP001944-01]; National Institute of Allergy and Infectious Diseases; University of North Carolina Center for AIDS Research [P30-AI50410]; NIH Fogarty AIDS International Training and Research Program [DHHS/NIH/FIC 2-D43 TW01039-06, R24 TW007988]; Infectious Disease Epidemiology Training Grant [5T32AI070114]; Elizabeth Glaser Pediatric AIDS Foundation; United Nations Children's Fund; World Food Program; Malawi Ministry of Health and Population; Johnson Johnson; U.S. Agency for International Development FX Funding: This work was funded by the National Institute of Allergy and Infectious Diseases at the National Institutes of Health [R03AI100694-A1]. The Breastfeeding, Antiretrovirals, and Nutrition Study was supported by grants from the Prevention Research Centers Special Interest Project of the Centers for Disease Control and Prevention (SIP 13-01 U48-CCU409660-09, SIP 26-04 U48-DP000059-01, and SIP 22-09 U48-DP001944-01), the National Institute of Allergy and Infectious Diseases, the University of North Carolina Center for AIDS Research (P30-AI50410), the NIH Fogarty AIDS International Training and Research Program (DHHS/NIH/FIC 2-D43 TW01039-06, the Fogarty International Clinical Research Scholars Program R24 TW007988; the American Recovery and Reinvestment Act), and the Infectious Disease Epidemiology Training Grant (5T32AI070114). The antiretrovirals used in the BAN study were donated by Abbott Laboratories, GlaxoSmithKline, Boehringer Ingelheim, Roche Pharmaceuticals, and Bristol-Myers Squibb. The Call to Action PMTCT program was supported by the Elizabeth Glaser Pediatric AIDS Foundation, the United Nations Children's Fund, the World Food Program, the Malawi Ministry of Health and Population, Johnson & Johnson, and the U.S. Agency for International Development. NR 31 TC 2 Z9 2 U1 0 U2 6 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6643 J9 NUTRIENTS JI Nutrients PD JAN PY 2015 VL 7 IS 1 BP 584 EP 594 DI 10.3390/nu7010584 PG 11 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AZ7ML UT WOS:000348402900031 PM 25594441 ER PT J AU Ridpath, AD Bregman, B Jones, L Reddy, V Waechter, H Balter, S AF Ridpath, Alison D. Bregman, Brooke Jones, Lucretia Reddy, Vasudha Waechter, Haena Balter, Sharon TI Challenges to Implementing Communicable Disease Surveillance in New York City Evacuation Shelters After Hurricane Sandy, November 2012 SO PUBLIC HEALTH REPORTS LA English DT Article ID INFECTIOUS-DISEASES; NATURAL DISASTERS; PREVENTION; EVACUEES; HOUSTON AB Hurricane Sandy hit New York City (NYC) on October 29, 2012. Before and after the storm, 73 temporary evacuation shelters were established. The total census of these shelters peaked at approximately 6,800 individuals. Concern about the spread of communicable diseases in shelters prompted the NYC Department of Health and Mental Hygiene (DOHMH) to rapidly develop a surveillance system to report communicable diseases and emergency department transports from shelters. We describe the implementation of this system. Establishing effective surveillance in temporary shelters was challenging and required in-person visits by DOHMH staff to ensure reporting. After system establishment, surveillance data were used to identify some potential disease clusters. For the future, we recommend pre-event planning for disease surveillance. C1 [Ridpath, Alison D.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Ridpath, Alison D.; Bregman, Brooke; Jones, Lucretia; Reddy, Vasudha; Waechter, Haena; Balter, Sharon] New York City Dept Hlth & Mental Hyg, New York, NY USA. RP Balter, S (reprint author), New York City Dept Hlth & Mental Hyg, Gotham Ctr 2, CN 22A,42-09 28th St, Queens, NY 11101 USA. EM sbalter@health.nyc.gov NR 18 TC 3 Z9 3 U1 1 U2 8 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2015 VL 130 IS 1 BP 48 EP 53 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY6ER UT WOS:000347660700006 PM 25552754 ER PT J AU Pitts, SI Apostolou, A DasGupta, S Delgado, N Kirn, TJ Montana, B Tan, C McHugh, LA AF Pitts, Samantha I. Apostolou, Andria DasGupta, Sarmila Delgado, Nelson Kirn, Thomas J. Montana, Barbara Tan, Christina McHugh, Lisa A. TI Serotype 10A in Case Patients with Invasive Pneumococcal Disease: A Pilot Study of PCR-Based Serotyping in New Jersey SO PUBLIC HEALTH REPORTS LA English DT Article ID STREPTOCOCCUS-PNEUMONIAE; POPULATION AB In 2008, the New Jersey Department of Health (NJDOH) identified a 21.1% increase in reported invasive pneumococcal disease (IPD). In 2009, NJDOH piloted nucleic acid-based serotyping to characterize serotypes causing IPD. From April through September, NJDOH received specimens from 149 of 302 (49%) case patients meeting our case definition. An uncommon serotype, 10A, accounted for 25.2% of IPD overall and was identified in 12 counties, but it was associated with one county (rate ratio = 5.4, 95% confidence interval [Cl] 2.1, 11.8). NJDOH subsequently conducted a case-control study to assess the presentation of and clinical risk factors for 10A IPD. Case patients with 10A IPD were more likely to have had immunosuppression, asthma, and multiple chronic medical conditions than control subjects had (odds ratio [OR] = 2.6, 95% Cl 1.1, 6.3; OR=4.7, 95% Cl 1.7, 13.2; and OR=2.3, 95% CI 1.0, 5.2, respectively). State-based pneumococcal serotype testing identified an uncommon serotype in New Jersey. Continued pneumococcal serotype surveillance might help the NJDOH identify and respond to future serotype-specific increases. C1 [Pitts, Samantha I.] Council State & Territorial Epidemiologists, Appl Epidemiol Fellowship, Atlanta, GA USA. [Pitts, Samantha I.; Apostolou, Andria; DasGupta, Sarmila; Montana, Barbara; McHugh, Lisa A.] New Jersey Dept Hlth, Off State Epidemiologist Environm & Occupat Hlth, Communicable Dis Serv, Trenton, NJ USA. [Pitts, Samantha I.; Delgado, Nelson] Johns Hopkins Univ, Sch Med, Div Gen Internal Med, Baltimore, MD 21287 USA. [Apostolou, Andria] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Kirn, Thomas J.] New Jersey Dept Hlth, Div Publ Hlth Infrastruct & Emergency Preparednes, Publ Hlth & Environm Labs, Trenton, NJ USA. [Kirn, Thomas J.] Rutgers State Univ, Robert Wood Johnson Med Sch, Dept Pathol & Lab Med, New Brunswick, NJ 08903 USA. [Tan, Christina] New Jersey Dept Hlth, Div Epidemiol Environm & Occupat Hlth, Trenton, NJ USA. RP Pitts, SI (reprint author), Johns Hopkins Univ, Sch Med, Div Gen Internal Med, 2024 E Monument St,Ste 2-611, Baltimore, MD 21287 USA. EM spitts4@jhmi.edu FU Centers for Disease Control and Prevention (CDC) [5U50CI223656-04]; CDC [5U38HM000414-5]; Comparative Effectiveness Development Training Award from Agency for Healthcare Research and Quality [1T32HS019488-02] FX This work was supported in part by the Centers for Disease Control and Prevention (CDC) (5U50CI223656-04 revised) and by an appointment to the Applied Epidemiology Fellowship Program administered by the Council of State and Territorial Epidemiologists and funded by CDC Cooperative Agreement #5U38HM000414-5. At the time of research, Dr. Pitts was supported through a Comparative Effectiveness Development Training Award, Grant #1T32HS019488-02, from the Agency for Healthcare Research and Quality. NR 12 TC 0 Z9 0 U1 0 U2 1 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2015 VL 130 IS 1 BP 54 EP 59 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY6ER UT WOS:000347660700007 PM 25552755 ER PT J AU Dietz, P Bombard, J Mulready-Ward, C Gauthier, J Sackoff, J Brozicevic, P Gambatese, M Nyland-Funke, M England, L Harrison, L Farr, S AF Dietz, Patricia Bombard, Jennifer Mulready-Ward, Candace Gauthier, John Sackoff, Judith Brozicevic, Peggy Gambatese, Melissa Nyland-Funke, Michael England, Lucinda Harrison, Leslie Farr, Sherry TI Validation of Selected Items on the 2003 US Standard Certificate of Live Birth: New York City and Vermont SO PUBLIC HEALTH REPORTS LA English DT Article ID HOSPITAL DISCHARGE DATA; PREGNANCY; VALIDITY AB Objective. We assessed the validity of selected items on the 2003 revised U.S. Standard Certificate of Live Birth to understand the accuracy of new and existing items. Methods. We calculated sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of select variables reported on the birth certificate using the medical record as the gold standard for a representative sample of live births in New York City (n=603) and Vermont (n=664) in 2009. Results. In both sites, sensitivity was excellent (>90%) for Medicaid coverage at delivery, any previous live births, and current method of delivery; sensitivity was moderate (70%-90%) for gestational diabetes; and sensitivity was poor (<70%) for premature rupture of the membranes and gestational hypertension. In both sites, PPV was excellent for Medicaid coverage, any previous live births, previous cesarean delivery, and current method of delivery, and poor for premature rupture of membranes. In both sites, almost all items had excellent (>90%) specificity and NPV. Conclusion. Further research is needed to determine how best to improve the quality of data on the birth certificate. Future revisions of the birth certificate may consider removing those items that have consistently proven difficult to report accurately. C1 [Dietz, Patricia; Bombard, Jennifer; England, Lucinda; Harrison, Leslie; Farr, Sherry] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA. [Mulready-Ward, Candace; Sackoff, Judith] New York City Dept Hlth & Mental Hyg, Gotham Ctr, Bur Maternal Infant & Reprod Hlth, Queens, NY USA. [Gauthier, John; Brozicevic, Peggy; Nyland-Funke, Michael] Vermont Dept Hlth, Agcy Human Serv, Burlington, VT 05402 USA. [Gambatese, Melissa] New York City Dept Hlth & Mental Hyg, Bur Vital Stat, New York, NY USA. RP Dietz, P (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, 1600 Clifton Rd NE,MS E-59, Atlanta, GA 30333 USA. EM pdietz@cdc.gov NR 19 TC 7 Z9 7 U1 0 U2 3 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2015 VL 130 IS 1 BP 60 EP 70 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY6ER UT WOS:000347660700008 PM 25552756 ER PT J AU Borges, CM Pathela, P Pirillo, R Blank, S AF Borges, Christine M. Pathela, Preeti Pirillo, Robert Blank, Susan TI Targeting the Use of Pooled HIV RNA Screening to Reduce Cost in Health Department STD Clinics: New York City, 2009-2011 SO PUBLIC HEALTH REPORTS LA English DT Article ID BLACK-MEN; INFECTION; SEX; PREVENTION; SYPHILIS; STATES; RISK AB Objective. Staff at public New York City sexually transmitted disease (STD) clinics screen patients for acute HIV infection (AHI) using pooled nucleic acid amplification tests. AHI screening is expensive but important for populations at high risk of acquiring HIV. We analyzed if targeting AHI screening in STD clinics could reduce program costs while maintaining AHI case detection. Methods. From January 2009 through May 2010, we screened all patients with negative rapid HIV tests for AHI. Using risk information on cases detected during this universal screening period, we developed criteria for targeted AHI screening and compared case yields and testing costs during 12 months of universal screening (June 2009 through May 2010) vs. 12 months of targeted screening (June 2010 through May 2011). Results. During the defined period of universal screening, we identified 40 AHI cases, and during targeted screening, we identified 35 AHI cases. Because of targeting efforts, the number needed to test to find one AHI case dropped from 1,631 to 254. With targeted screening, it cost an average of $4,535 per case detected and 39.3 cases were detected per 10,000 specimens; using universal screening, $29,088 was spent per case detected and 6.1 cases were detected per 10,000 specimens processed. Conclusion. Targeted screening identified similar numbers of AHI cases as when screening all clinic patients seeking HIV testing, but at one-seventh the cost. C1 [Borges, Christine M.; Pathela, Preeti; Blank, Susan] New York City Dept Hlth & Mental Hyg, Bur Sexually Transmitted Dis Control, Queens, NY 11101 USA. [Pirillo, Robert] New York City Dept Hlth & Mental Hyg, Bur Publ Hlth Lab, Queens, NY 11101 USA. [Blank, Susan] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, Atlanta, GA USA. RP Borges, CM (reprint author), New York City Dept Hlth & Mental Hyg, Bur Sexually Transmitted Dis Control, 42-09 28th St,WS 20-52, Queens, NY 11101 USA. EM cborges@health.nyc.gov NR 24 TC 3 Z9 3 U1 2 U2 2 PU ASSOC SCHOOLS PUBLIC HEALTH PI WASHINGTON PA 1900 M ST NW, STE 710, WASHINGTON, DC 20036 USA SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD JAN-FEB PY 2015 VL 130 IS 1 BP 81 EP 86 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY6ER UT WOS:000347660700010 PM 25552758 ER PT J AU Hafiz, I Berhan, M Keller, A Haq, R Chesnaye, N Koporc, K Rahman, M Rahman, S Mathieu, E AF Hafiz, Israt Berhan, Meklit Keller, Angela Haq, Rouseli Chesnaye, Nicholas Koporc, Kim Rahman, Mujibur Rahman, Shamsur Mathieu, Els TI School-based mass distributions of mebendazole to control soil-transmitted helminthiasis in the Munshiganj and Lakshmipur districts of Bangladesh: An evaluation of the treatment monitoring process and knowledge, attitudes, and practices of the population SO ACTA TROPICA LA English DT Article DE STH; Bangladesh; Mebendazole; Process evaluation; Mass drug administration; Treatment coverage survey ID SCHISTOSOMIASIS CONTROL; CONTROL PROGRAMS; DRUG COVERAGE; AGE-CHILDREN; EXPERIENCE; INFECTIONS; EGYPT AB Bangladesh's national deworming program targets school-age children (SAC) through bi-annual school-based distributions of mebendazole. Qualitative and quantitative methods were applied to identify challenges related to treatment monitoring within the Munshiganj and Lakshmipur Districts of Bangladesh. Key stakeholder interviews identified several obstacles for successful treatment monitoring within these districts; ambiguity in defining the target population, variances in the methods used for compiling and reporting treatment data, and a general lack of financial and human resources. A treatment coverage cluster survey revealed that bi-annual primary school-based distributions proved to be an effective strategy in reaching school-attending SAC, with rates between 63.0% and 73.3%. However, the WHO target of regular treatment of at least 75% of SAC has yet to be reached. Particularly low coverage was seen amongst non-school attending children (11.4-14.3%), most likely due to the lack of national policy to effectively target this vulnerable group. Survey findings on water and sanitation coverage were impressive with the majority of households and schools having access to latrines (98.6-993%) and safe drinking water (98.2-100%). The challenge now for the Bangladeshi control program is to achieve the WHO target of regular treatment of at least 75% of SAC at risk, irrespective of school-enrollment status. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved. C1 [Hafiz, Israt; Haq, Rouseli; Rahman, Mujibur; Rahman, Shamsur] MOH&FW, Dhaka, Bangladesh. [Berhan, Meklit; Koporc, Kim] Task Force Global Hlth, Children Worms, Atlanta, GA USA. [Keller, Angela; Chesnaye, Nicholas; Mathieu, Els] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA USA. RP Mathieu, E (reprint author), CDC, Ctr Global Hlth, Blg 21,9210-3,1600 Clifton Rd NE, Atlanta, GA 30329 USA. EM dr.ihafiz2012@gmail.com; mberhan@gmail.com; angela.j.keller@gmail.com; dr.rouselihaq@gmail.com; nchesnaye@gmail.com; kkoporc@taskforce.org; drmujib.rahman@gmail.com; mirsamsut@gmail.com; emm7@cdc.gov FU Directorate General of Health Services under the Ministry of Health and Family Welfare of Bangladesh FX The authors wish to thank the survey staff, program staff of the Filariasis Elimination and STH Control Program, and the Directorate General of Health Services under the Ministry of Health and Family Welfare of Bangladesh for their support. NR 21 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X EI 1873-6254 J9 ACTA TROP JI Acta Trop. PD JAN PY 2015 VL 141 SI SI BP 385 EP 390 DI 10.1016/j.actatropica.2013.12.010 PN B PG 6 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA AY4ZK UT WOS:000347583200033 PM 24370675 ER PT J AU Munoz, F Burgos, JL Cuevas-Mota, J Teshale, E Garfein, RS AF Munoz, Fatima Burgos, Jose Luis Cuevas-Mota, Jazmine Teshale, Eyasu Garfein, Richard S. TI Individual and Socio-Environmental Factors Associated with Unsafe Injection Practices Among Young Adult Injection Drug Users in San Diego SO AIDS AND BEHAVIOR LA English DT Article DE HIV/AIDS; Hepatitis C virus; Injection drug use; Unsafe injection practices; Risk perception ID BLOOD-BORNE INFECTIONS; 5 US CITIES; RISK BEHAVIORS; UNITED-STATES; HEPATITIS-C; HIV RISK; PERCEIVED CONSEQUENCES; GENDER-DIFFERENCES; VIRAL-INFECTIONS; MEXICO AB Unsafe injection practices significantly increase the risk of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infection among injection drug users (IDUs). We examined individual and socio-environmental factors associated with unsafe injection practices in young adult IDUs in San Diego, California. Of 494 IDUs, 46.9 % reported receptive syringe sharing and 68.8 % sharing drug preparation paraphernalia in the last 3 months. Unsafe injection practices were associated with increased odds of having friends who injected drugs with used syringes, injecting with friends or sexual partners, and injecting heroin. Perceived high susceptibility to HIV and perceived barriers to obtaining sterile syringes were associated with increased odds of receptive syringe sharing, but not with sharing injection paraphernalia. Over half the IDUs reported unsafe injection practices. Our results suggest that personal relationships might influence IDUs' perceptions that dictate behavior. Integrated interventions addressing individual and socio-environmental factors are needed to promote safe injection practices in this population. C1 [Munoz, Fatima; Burgos, Jose Luis; Cuevas-Mota, Jazmine; Garfein, Richard S.] Univ Calif San Diego, Sch Med, Dept Med, Div Global Publ Hlth, La Jolla, CA 92093 USA. [Teshale, Eyasu] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. RP Garfein, RS (reprint author), Univ Calif San Diego, Sch Med, Dept Med, Div Global Publ Hlth, 9500 Gilman Dr, La Jolla, CA 92093 USA. EM rgarfein@ucsd.edu FU NIAID NIH HHS [P01 AI074621, P30 AI036214, T32 AI007384, AI074621, AI36214, AI007384]; NIDA NIH HHS [R01 DA031074]; NIMH NIH HHS [K01 MH095680]; PHS HHS [200-2007-21016, 2T32A1007384-21A1] NR 65 TC 2 Z9 2 U1 2 U2 2 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 EI 1573-3254 J9 AIDS BEHAV JI AIDS Behav. PD JAN PY 2015 VL 19 IS 1 BP 199 EP 210 DI 10.1007/s10461-014-0815-y PG 12 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA AZ6OT UT WOS:000348339500023 PM 24920342 ER PT J AU Mpimbaza, A Miles, M Sserwanga, A Kigozi, R Wanzira, H Rubahika, D Nasr, S Kapella, BK Yoon, SS Chang, M Yeka, A Staedke, SG Kamya, MR Dorsey, G AF Mpimbaza, Arthur Miles, Melody Sserwanga, Asadu Kigozi, Ruth Wanzira, Humphrey Rubahika, Denis Nasr, Sussann Kapella, Bryan K. Yoon, Steven S. Chang, Michelle Yeka, Adoke Staedke, Sarah G. Kamya, Moses R. Dorsey, Grant TI Short Report: Comparison of Routine Health Management Information System Versus Enhanced Inpatient Malaria Surveillance for Estimating the Burden of Malaria Among Children Admitted to Four Hospitals in Uganda SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID DIAGNOSIS; TANZANIA AB The primary source of malaria surveillance data in Uganda is the Health Management Information System (HMIS), which does not require laboratory confirmation of reported malaria cases. To improve data quality, an enhanced inpatient malaria surveillance system (EIMSS) was implemented with emphasis on malaria testing of all children admitted in select hospitals. Data were compared between the HMIS and the EIMSS at four hospitals over a period of 12 months. After the implementation of the EIMSS, over 96% of admitted children under 5 years of age underwent laboratory testing for malaria. The HMIS significantly overreported the proportion of children under 5 years of age admitted with malaria (average absolute difference = 19%, range = 8-27% across the four hospitals) compared with the EIMSS. To improve the quality of the HMIS data for malaria surveillance, the National Malaria Control Program should, in addition to increasing malaria testing rates, focus on linking laboratory test results to reported malaria cases. C1 [Mpimbaza, Arthur] Makerere Univ, Coll Hlth Sci, Child Hlth & Dev Ctr, Kampala, Uganda. [Sserwanga, Asadu; Kigozi, Ruth] Infect Dis Res Collaborat, Kampala, Uganda. Minist Hlth Uganda, Natl Malaria Control Program, Kampala, Uganda. [Yoon, Steven S.; Chang, Michelle] Ctr Dis Control & Prevent, US Presidents Malaria Initiat, Malaria Branch, Atlanta, GA USA. Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Kampala, Uganda. London Sch Hyg & Trop Med, London WC1, England. Makerere Univ, Coll Hlth Sci, Dept Med, Kampala, Uganda. Univ Calif San Francisco, San Francisco Gen Hosp, Dept Med, San Francisco, CA USA. [Mpimbaza, Arthur; Yeka, Adoke; Kamya, Moses R.] Makerere Univ, Coll Hlth Sci, Kampala, Uganda. [Miles, Melody] Gates Fdn, Seattle, WA USA. [Wanzira, Humphrey; Rubahika, Denis] Uganda Natl Malaria Control Program, Kampala, Uganda. [Nasr, Sussann] Ctr Dis Control & Prevent, US Presidents Malaria Initiat, Malaria Branch, Luanda, Angola. [Kapella, Bryan K.] Ctr Dis Control & Prevent, US Presidents Malaria Initiat, Malaria Branch, Kampala, Uganda. [Staedke, Sarah G.] London Sch Hyg & Trop Med, Kampala, Uganda. [Dorsey, Grant] Univ Calif San Francisco, San Francisco, CA 94143 USA. RP Mpimbaza, A (reprint author), Makerere Univ, Coll Hlth Sci, Child Hlth & Dev Ctr, POB 6717, Kampala, Uganda. EM arthurwakg@yahoo.com; melody.miles@gatesfoundation.org; asserwanga@muucsf.org; rkigozi@muucsf.org; wanzirah@yahoo.co; drubahika@yahoo.com; Snasr@usaid.gov; bkapella@usaid.gov; say7@cdc.gov; aup6@cdc.gov; yadoke@muucsf.org; sarah.staedke@lshtm.ac.uk; kamya@infocom.co.ug; gdorsey@medsfgh.ucsf.edu FU President's Malaria Initiative, US Agency for International Development [1U51CK000117]; Centers for Disease Control and Prevention FX This publication was made possible through support provided by the President's Malaria Initiative, US Agency for International Development under the terms of Interagency Agreement 1U51CK000117 with the Centers for Disease Control and Prevention. NR 20 TC 1 Z9 1 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2015 VL 92 IS 1 BP 18 EP 21 DI 10.4269/ajtmh.14-0284 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AZ4GU UT WOS:000348180600007 PM 25422396 ER PT J AU Clark, EH Marks, MA Gilman, RH Fernandez, AB Crawford, TC Samuels, AM Hidron, AI Galdos-Cardenas, G Menacho-Mendez, GS Bozo-Gutierrez, RW Martin, DL Bern, C AF Clark, Eva H. Marks, Morgan A. Gilman, Robert H. Fernandez, Antonio B. Crawford, Thomas C. Samuels, Aaron M. Hidron, Alicia I. Galdos-Cardenas, Gerson Silvio Menacho-Mendez, Gilberto Bozo-Gutierrez, Ricardo W. Martin, Diana L. Bern, Caryn TI Circulating Serum Markers and QRS Scar Score in Chagas Cardiomyopathy SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MATRIX METALLOPROTEINASES 2; TISSUE GROWTH-FACTOR; FORMER BLOOD-DONORS; TRYPANOSOMA-CRUZI; HEART-DISEASE; ELECTROCARDIOGRAPHIC ABNORMALITIES; MYOCARDIAL SCAR; RURAL-COMMUNITY; FOLLOW-UP; TGF-BETA AB Approximately 8 million people have Trypanosoma cruzi infection, and nearly 30% will manifest Chagas cardiomyopathy (CC). Identification of reliable early indicators of CC risk would enable prioritization of treatment to those with the highest probability of future disease. Serum markers and electrocardiogram (EKG) changes were measured in 68 T. cruzi-infected individuals in various stages of cardiac disease and 17 individuals without T cruzi infection or cardiac disease. T. cruzi-infected individuals were assigned to stage A (normal EKG/chest x-ray [CXR]), B (abnormal EKG/normal CXR), or C (abnormal EKG/cardiac structural changes). Ten serum markers were measured using enzyme-linked immunosorbent assay (ELISA)/Luminex, and QRS scores were calculated. Higher concentrations of transforming growth factor-beta 1 (TGF beta 1), and TGF beta 2 were associated with stage B compared with stage A. Matrix Metalloproteinase 2 (MMP2), Tissue Inhibitors of MMP 1, QRS score, and Brain Natriuretic Protein rose progressively with increasing CC severity. Elevated levels of several markers of cardiac damage and inflammation are seen in early CC and warrant additional evaluation in longitudinal studies. C1 [Clark, Eva H.] Univ Alabama Birmingham, Birmingham, AL 35209 USA. [Marks, Morgan A.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Gilman, Robert H.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Fernandez, Antonio B.] Hartford Hosp, Dept Med, Div Cardiol, Hartford, CT 06115 USA. [Crawford, Thomas C.] Univ Michigan Hlth Syst, Dept Cardiol, Ann Arbor, MI USA. [Samuels, Aaron M.; Martin, Diana L.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hidron, Alicia I.] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA. [Galdos-Cardenas, Gerson] Hosp Univ Japones, Santa Cruz, Bolivia. [Silvio Menacho-Mendez, Gilberto] Ctr Salud Eiti, Gutierrez, Bolivia. [Bozo-Gutierrez, Ricardo W.] Hosp Municipal Camiri, Camiri, Bolivia. [Bern, Caryn] Univ Calif San Francisco, San Francisco, CA 94143 USA. RP Clark, EH (reprint author), Univ Alabama Birmingham, Room SHEL 121,1825 Univ Blvd, Birmingham, AL 35209 USA. EM eva.clark@bcm.edu; mmarksster@gmail.com; gilmanbob@gmail.com; antoinefernandezt@hotmail.com; thomcraw@med.umich.edu; iyp2@cdc.gov; aliciahidron@gmail.com; gersongaldos@gmail.com; gsmmjovero@gmail.com; ricardobozo_1966@hotmail.com; hzx3@cdc.gov; Caryn.Bern2@ucsf.edu FU National Institute of Health (NIH) [5 P50 AI074285]; NIH Fogarty Scholars Program Grant [R24TW007988]; NIH Training Grant in Infectious and Tropical Diseases [5 T35 AI065385]; NIH Global Research Training Grant [D43 TW006581]; NIH [5R25TW008102] FX This work was supported by National Institute of Health (NIH) Grant 5 P50 AI074285, NIH Fogarty Scholars Program Grant R24TW007988, NIH Training Grant in Infectious and Tropical Diseases 5 T35 AI065385, and NIH Global Research Training Grant D43 TW006581. The participation of A.B.F. was supported by NIH-funded "Interdisciplinary Framework in Global Health at Brown University" Grant 5R25TW008102. Support was also provided by the Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention for the participation of A.M.S. and D.L.M. and specimen processing. NR 43 TC 1 Z9 1 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2015 VL 92 IS 1 BP 39 EP 44 DI 10.4269/ajtmh.14-0246 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AZ4GU UT WOS:000348180600011 PM 25385865 ER PT J AU Moncayo, AC Baumblatt, J Thomas, D Harvey, KA Atrubin, D Stanek, D Sotir, M Hunsperger, E Munoz-Jordan, JL Jentes, ES Sharp, TM Arguello, DF AF Moncayo, Abelardo C. Baumblatt, Jane Thomas, Dana Harvey, Kira A. Atrubin, David Stanek, Danielle Sotir, Mark Hunsperger, Elizabeth Munoz-Jordan, Jorge L. Jentes, Emily S. Sharp, Tyler M. Arguello, D. Fermin TI Short Report: Dengue among American Missionaries Returning from Jamaica, 2012 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SURVEILLANCE; TRAVELERS; ASSAY AB Dengue is an acute febrile illness caused by any of four mosquito-transmitted dengue virus (DENV) types. Dengue is endemic in Jamaica, where an epidemic occurred in 2012. An investigation was conducted by multiple agencies for 66 missionaries traveling from nine US states to Jamaica after 1 missionary from the group was confirmed to have dengue. Travelers were offered diagnostic testing, and a survey was administered to assess knowledge, behaviors, and illness. Of 42 survey respondents, 9 (21%) respondents reported an acute febrile illness during or after travel to Jamaica. Of 15 travelers that provided serum specimens, 4 (27%) travelers had detectable anti-DENV immunoglobulin M antibody, and 1 traveler also had DENV-1 detected by reverse transcriptase polymerase chain reaction. Recent or past infection with a DENV was evident in 93% (13 of 14) missionaries with available sera. No behavioral or demographic factors were significantly associated with DENV infection. This investigation shows that even trips of short duration to endemic areas present a risk of acquiring dengue. C1 Tennessee Dept Hlth, Nashville, TN USA. [Baumblatt, Jane] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Hunsperger, Elizabeth; Sharp, Tyler M.; Arguello, D. Fermin] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Dis, San Juan, PR USA. [Thomas, Dana; Harvey, Kira A.; Sotir, Mark] Ctr Dis Control & Prevent, Travelers Hlth Branch, Div Global Migrat & Quarantine, Atlanta, GA USA. Florida Dept Hlth, Tallahassee, FL USA. [Moncayo, Abelardo C.; Baumblatt, Jane] Tennessee Dept Hlth, Vector Borne Dis Sect, Communicable Dis Serv, Nashville, TN USA. [Moncayo, Abelardo C.; Baumblatt, Jane] Tennessee Dept Hlth, Vector Borne Dis Sect, Environm Dis Serv, Nashville, TN USA. [Atrubin, David; Stanek, Danielle] Florida Dept Hlth, Div Dis Control & Prevent, Tallahassee, FL USA. [Munoz-Jordan, Jorge L.] Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR USA. [Jentes, Emily S.] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA USA. RP Moncayo, AC (reprint author), 630 Hart Lane, Nashville, TN 37216 USA. EM Abelardo.Moncayo@tn.gov; Jane.Baumblatt@ahrq.hhs.gov; wii6@cdc.gov; jii3@cdc.gov; David.Atrubin@flhealth.gov; Danielle.Stanek@flhealth.gov; mps6@cdc.gov; enh4@cdc.gov; ckq2@cdc.gov; efj8@cdc.gov; tsharp@cdc.gov; darguello@cdc.gov NR 10 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2015 VL 92 IS 1 BP 69 EP 71 DI 10.4269/ajtmh.14-0341 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AZ4GU UT WOS:000348180600016 PM 25371185 ER PT J AU Lindsey, NP Prince, HE Kosoy, O Laven, J Messenger, S Staples, JE Fischer, M AF Lindsey, Nicole P. Prince, Harry E. Kosoy, Olga Laven, Janeen Messenger, Sharon Staples, J. Erin Fischer, Marc TI Chikungunya Virus Infections Among Travelers United States, 2010-2013 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID FEVER; DIAGNOSIS; AMERICA; REGION; ASSAY AB Chikungunya virus is an emerging threat to the United States because humans are amplifying hosts and competent mosquito vectors are present in many regions of the country. We identified laboratory-confirmed chikungunya virus infections with diagnostic testing performed in the United States from 2010 through 2013. We described the epidemiology of these cases and determined which were reported to ArboNET. From 2010 through 2013, 115 laboratory-confirmed chikungunya virus infections were identified. Among 55 cases with known travel history, 53 (96%) reported travel to Asia and 2 (4%) to Africa. No locally-acquired infections were identified. Six patients had detectable viremia after returning to the United States. Only 21% of identified cases were reported to ArboNET, with a median of 72 days between illness onset and reporting. Given the risk of introduction into the United States, healthcare providers and public health officials should be educated about the recognition, diagnosis, and timely reporting of chikungunya virus disease cases. C1 Ctr Dis Control & Prevent, Arboviral Dis Branch, Ft Collins, CO 80521 USA. [Prince, Harry E.] Focus Diagnost, Cypress, CA USA. [Messenger, Sharon] Calif Dept Publ Hlth, Viral & Rickettsial Dis Lab Branch, Richmond, CA USA. [Lindsey, Nicole P.; Kosoy, Olga; Laven, Janeen; Staples, J. Erin; Fischer, Marc] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Lindsey, NP (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, 3156 Rampart Rd, Ft Collins, CO 80521 USA. EM nplindsey@cdc.gov; hprince@focusdx.com; okosoy@cdc.gov; jlaveen@cdc.gov; Sharon.Messenger@cdph.ca.gov; estaples@cdc.gov; mfischer@cdc.gov NR 23 TC 15 Z9 15 U1 2 U2 19 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2015 VL 92 IS 1 BP 82 EP 87 DI 10.4269/ajtmh.14-0442 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AZ4GU UT WOS:000348180600019 PM 25349374 ER PT J AU Kahler, AM Haley, BJ Chen, A Mull, BJ Tarr, CL Turnsek, M Katz, LS Humphrys, MS Derado, G Freeman, N Boncy, J Colwell, RR Huq, A Hill, VR AF Kahler, Amy M. Haley, Bradd J. Chen, Arlene Mull, Bonnie J. Tarr, Cheryl L. Turnsek, Maryann Katz, Lee S. Humphrys, Michael S. Derado, Gordana Freeman, Nicole Boncy, Jacques Colwell, Rita R. Huq, Anwar Hill, Vincent R. TI Environmental Surveillance for Toxigenic Vibrio cholerae in Surface Waters of Haiti SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LONGITUDINAL DATA-ANALYSIS; MAXIMUM-LIKELIHOOD; BANGLADESH WATERS; DIVERSE MICROBES; MULTIPLEX PCR; O1; ULTRAFILTRATION; RECOVERY; SAMPLES; ALIGNMENT AB Epidemic cholera was reported in Haiti in 2010, with no information available on the occurrence or geographic distribution of toxigenic Vibrio cholerae in Haitian waters. In a series of field visits conducted in Haiti between 2011 and 2013, water and plankton samples were collected at 19 sites. Vibrio cholerae was detected using culture, polymerase chain reaction, and direct viable count methods (DFA-DVC). Cholera toxin genes were detected by polymerase chain reaction in broth enrichments of samples collected in all visits except March 2012. Toxigenic V. cholerae was isolated from river water in 2011 and 2013. Whole genome sequencing revealed that these isolates were a match to the outbreak strain. The DFA-DVC tests were positive for V. cholerae 01 in plankton samples collected from multiple sites. Results of this survey show that toxigenic V. cholerae could be recovered from surface waters in Haiti more than 2 years after the onset of the epidemic. C1 [Hill, Vincent R.] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. Univ Maryland, College Pk, MD 20742 USA. [Freeman, Nicole; Boncy, Jacques] Natl Publ Hlth Lab, Haitian Minist Publ Hlth & Populat, Port Au Prince, Haiti. [Kahler, Amy M.; Haley, Bradd J.; Tarr, Cheryl L.; Turnsek, Maryann; Katz, Lee S.; Humphrys, Michael S.; Derado, Gordana; Hill, Vincent R.] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30329 USA. [Haley, Bradd J.; Chen, Arlene; Colwell, Rita R.; Huq, Anwar] Univ Maryland, Maryland Pathogen Res Inst, College Pk, MD 20742 USA. [Haley, Bradd J.; Chen, Arlene; Colwell, Rita R.; Huq, Anwar] Univ Maryland, Ctr Bioinformat & Computat Biol, College Pk, MD 20742 USA. RP Hill, VR (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop D-66, Atlanta, GA 30329 USA. EM akahler@cdc.gov; bradd.haley@gmail.com; achen87@umd.edu; bonniejmull@gmail.com; ctarr@cdc.gov; HUD4@cdc.gov; GZU2@cdc.gov; msh06f@gmail.com; uwx8@cdc.gov; nicolemfreeman@gmail.com; jboncy2001@yahoo.fr; rcolwell@umiacs.umd.edu; huqanwar@gmail.com; vhill@cdc.gov FU Centers for Disease Control and Prevention; NIH [2RO1A1039129-11A2]; NSF [0813066] FX Centers for Disease Control and Prevention, partial support at the University of Maryland came from NIH grant no. 2RO1A1039129-11A2 and NSF grant no. 0813066. NR 41 TC 5 Z9 5 U1 1 U2 13 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2015 VL 92 IS 1 BP 118 EP 125 DI 10.4269/ajtmh.13-0601 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AZ4GU UT WOS:000348180600024 PM 25385860 ER PT J AU Chi, KH Danavall, D Taleo, F Pillay, A Ye, T Nachamkin, E Kool, JL Fegan, D Asiedu, K Vestergaard, LS Ballard, RC Chen, CY AF Chi, Kai-Hua Danavall, Damien Taleo, Fasihah Pillay, Allan Ye, Tun Nachamkin, Eli Kool, Jacob L. Fegan, David Asiedu, Kingsley Vestergaard, Lasse S. Ballard, Ronald C. Chen, Cheng-Yen TI Molecular Differentiation of Treponema pallidum Subspecies in Skin Ulceration Clinically Suspected as Yaws in Vanuatu Using Real-Time Multiplex PCR and Serological Methods SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HAEMOPHILUS-DUCREYI; CROSS-REACTIVITY; SYPHILIS; GENE; SEQUENCES; DIAGNOSIS; PERTENUE; CHILDREN; ULCERS AB We developed a TaqMan-based real-time quadriplex polymerase chain reaction (PCR) to simultaneously detect Treponema pallidum subspecies pallidum, T. pallidum subsp. pertenue, and T. pallidum subsp. endemicum, the causative agents of venereal syphilis, yaws, and bejel, respectively. The PCR assay was applied to samples from skin ulcerations of clinically presumptive yaws cases among children on Tanna Island, Vanuatu. Another real-time triplex PCR was used to screen for the point mutations in the 23S rRNA genes that have previously been associated with azithromycin resistance in T. pallidum subsp. pallidum strains. Seropositivity by the classical syphilis serological tests was 35.5% among children with skin ulcerations clinically suspected with yaws, whereas the presence of T. pallidum subsp. pertenue DNA was only found in lesions from 15.5% of children. No evidence of T. pallidum subsp. pertenue infection, by either PCR or serology was found in similar to 59% of cases indicating alternative causes of yaws-like lesions in this endemic area. C1 Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Lab Reference & Res Branch, Div STD Prevent, Atlanta, GA USA. Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. Minist Hlth, Port Vila, Vanuatu. Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA 30329 USA. WHO, Port Vila, Vanuatu. [Fegan, David] WHO, Brisbane, Qld, Australia. WHO, Dept Control Neglected Trop Dis, CH-1211 Geneva, Switzerland. [Vestergaard, Lasse S.] WHO, Western Pacific Reg Off, Manila, Philippines. [Chi, Kai-Hua; Danavall, Damien; Pillay, Allan; Ye, Tun; Nachamkin, Eli; Chen, Cheng-Yen] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30329 USA. [Ballard, Ronald C.] Ctr Global Hlth, CDC, Atlanta, GA USA. [Taleo, Fasihah] NTD Program, Minist Hlth, Dept Hlth, Port Vila, Vanuatu. [Kool, Jacob L.] WHO, Off South Pacific, Port Vila, Vanuatu. [Asiedu, Kingsley] WHO, CH-1211 Geneva, Switzerland. RP Chen, CY (reprint author), Ctr Dis Control & Prevent, Div STD Prevent, 1600 Clifton Rd,Mail Stop A-12, Atlanta, GA 30329 USA. EM krc2@cdc.gov; bpu8@cdc.gov; ftaleo@vanuatu.gov.vu; ajp7@cdc.gov; gwr5@cdc.gov; ecn1@cdc.gov; KoolJ@wpro.who.int; djfegan@gmail.com; asieduk@who.int; vestergaardl@wpro.who.int; ztp7@cdc.gov; cychen@cdc.gov FU World Health Organization [001] NR 21 TC 10 Z9 10 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2015 VL 92 IS 1 BP 134 EP 138 DI 10.4269/ajtmh.14-0459 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AZ4GU UT WOS:000348180600027 PM 25404075 ER PT J AU Villacis, AG Ocana-Mayorga, S Lascano, MS Yumiseva, CA Baus, EG Grijalva, MJ AF Villacis, Anita G. Ocana-Mayorga, Sofia Lascano, Mauricio S. Yumiseva, Cesar A. Baus, Esteban G. Grijalva, Mario J. TI Abundance, Natural Infection with Trypanosomes, and Food Source of an Endemic Species of Triatomine, Panstrongylus howardi (Neiva 1911), on the Ecuadorian Central Coast SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CHAGAS-DISEASE; REDUVIIDAE; ECOLOGY; CRUZI; HETEROPTERA; EVOLUTION; HEMIPTERA; VECTORS; RANGELI; AMPLIFICATION AB The elimination of domestic triatomines is the foundation of Chagas disease control. Regional initiatives are eliminating introduced triatomine species. In this scenario, endemic triatomines can occupy the ecological niches left open and become a threat to long-term Chagas disease control efforts. This study determined the abundance, colonization, and Trypanosoma cruzi infection rate of the endemic Panstrongylus howardi in 10 rural communities located in Ecuador's Manabi Province. In total, 518 individuals of P. howardi were collected. Infestation indices of 1.4% and 6.6% were found in the domestic and peridomestic environments, respectively. We determined a T. cruzi infection rate of 53.2% (N = 47) in this species. P. howardi has a high capacity to adapt to different habitats, especially in the peridomicile. This implies a considerable risk of transmission because of the frequency of intradomicile invasion. Therefore, this species needs to be taken into account in Chagas control and surveillance efforts in the region. C1 [Villacis, Anita G.; Ocana-Mayorga, Sofia; Yumiseva, Cesar A.; Baus, Esteban G.] Pontifical Catholic Univ Ecuador, Sch Biol Sci, Ctr Infect Dis Res, Quito, Ecuador. [Grijalva, Mario J.] Ohio Univ, Trop Dis Inst, Dept Biomed Sci, Heritage Coll Osteopath Med, Athens, OH 45701 USA. [Lascano, Mauricio S.] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Parasit Dis & Malaria, Atlanta, GA USA. RP Grijalva, MJ (reprint author), Ohio Univ, 333 Irvine Hall, Athens, OH 45701 USA. EM agvillacis@puce.edu.ec; sbocana@puce.edu.ec; SLascano@cdc.gov; cayumiseva@puce.edu.ec; egbaus@puce.edu.ec; grijalva@ohio.edu OI Grijalva, Mario/0000-0003-1964-1425 FU United Nations Children's Fund (UNICEF) - United Nations Development Programme (UNDP)/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases Research Capability Strengthening Group; Ohio University Heritage College of Osteopathic Medicine; Pontifical Catholic University of Ecuador; Children's Heart link; Plan International Ecuador FX Financial support was received from The United Nations Children's Fund (UNICEF) - United Nations Development Programme (UNDP)/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases Research Capability Strengthening Group, Ohio University Heritage College of Osteopathic Medicine, Pontifical Catholic University of Ecuador, Children's Heart link, and Plan International Ecuador. NR 29 TC 5 Z9 6 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2015 VL 92 IS 1 BP 187 EP 192 DI 10.4269/ajtmh.14-0250 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA AZ4GU UT WOS:000348180600035 PM 25385867 ER PT J AU Mercante, JW Winchell, JM AF Mercante, Jeffrey W. Winchell, Jonas M. TI Current and Emerging Legionella Diagnostics for Laboratory and Outbreak Investigations SO CLINICAL MICROBIOLOGY REVIEWS LA English DT Review ID REAL-TIME PCR; POLYMERASE-CHAIN-REACTION; COMMUNITY-ACQUIRED PNEUMONIA; NOSOCOMIAL LEGIONNAIRES-DISEASE; PNEUMOPHILA SEROGROUP 1; RESOLUTION MELT ANALYSIS; COOLING-TOWER WATER; NUCLEIC-ACID AMPLIFICATION; MEDIATED ISOTHERMAL AMPLIFICATION; SEQUENCE-BASED AMPLIFICATION AB Legionnaires' disease (LD) is an often severe and potentially fatal form of bacterial pneumonia caused by an extensive list of Legionella species. These ubiquitous freshwater and soil inhabitants cause human respiratory disease when amplified in man-made water or cooling systems and their aerosols expose a susceptible population. Treatment of sporadic cases and rapid control of LD outbreaks benefit from swift diagnosis in concert with discriminatory bacterial typing for immediate epidemiological responses. Traditional culture and serology were instrumental in describing disease incidence early in its history; currently, diagnosis of LD relies almost solely on the urinary antigen test, which captures only the dominant species and serogroup, Legionella pneumophila serogroup 1 (Lp1). This has created a diagnostic "blind spot" for LD caused by non-Lp1 strains. This review focuses on historic, current, and emerging technologies that hold promise for increasing LD diagnostic efficiency and detection rates as part of a coherent testing regimen. The importance of cooperation between epidemiologists and laboratorians for a rapid outbreak response is also illustrated in field investigations conducted by the CDC with state and local authorities. Finally, challenges facing health care professionals, building managers, and the public health community in combating LD are highlighted, and potential solutions are discussed. C1 [Mercante, Jeffrey W.; Winchell, Jonas M.] US Ctr Dis Control & Prevent, Resp Dis Branch, Pneumonia Response & Surveillance Lab, Atlanta, GA 30333 USA. RP Mercante, JW (reprint author), US Ctr Dis Control & Prevent, Resp Dis Branch, Pneumonia Response & Surveillance Lab, Atlanta, GA 30333 USA. EM jwinchell@cdc.gov NR 580 TC 32 Z9 37 U1 6 U2 50 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0893-8512 EI 1098-6618 J9 CLIN MICROBIOL REV JI Clin. Microbiol. Rev. PD JAN PY 2015 VL 28 IS 1 BP 95 EP 133 DI 10.1128/CMR.00029-14 PG 39 WC Microbiology SC Microbiology GA AY3BU UT WOS:000347460400005 PM 25567224 ER PT J AU Bellcross, CA Peipins, LA McCarty, FA Rodriguez, JL Hawkins, NA Alford, SH Leadbetter, S AF Bellcross, Cecelia A. Peipins, Lucy A. McCarty, Frances A. Rodriguez, Juan L. Hawkins, Nikki A. Alford, Sharon Hensley Leadbetter, Steven TI Characteristics associated with genetic counseling referral and BRCA1/2 testing among women in a large integrated health system SO GENETICS IN MEDICINE LA English DT Article DE BRCA1 and BRCA2 genes; family history; genetic counseling; genetic testing; hereditary breast and ovarian cancer syndrome ID BREAST-CANCER RISK; SERVICES-TASK-FORCE; OVARIAN-CANCER; HEREDITARY BREAST; FAMILY-HISTORY; PRIMARY-CARE; RECOMMENDATION STATEMENT; MUTATION CARRIERS; ATTITUDES; KNOWLEDGE AB Background: Evidence shows underutilization of cancer genetics services. To explore the reasons behind this underutilization, this study evaluated characteristics of women who were referred for genetic counseling and/or had undergone BRCA1/2 testing. Methods: An ovarian cancer risk perception study stratified 16,720 eligible women from the Henry Ford Health System into average-, elevated-, and high-risk groups based on family history. We randomly selected 3,307 subjects and interviewed 2,524 of them (76.3% response rate). Results: Among the average-, elevated-, and, high-risk groups, 2.3, 10.1, and 20.2%, respectively, reported genetic counseling referrals, and 0.8, 3.3, and 9.5%, respectively, reported having undergone BRA testing, Personal breast cancer history, high risk, and perceived ovarian cancer risk were associated with both referral and testing. Discussion of family history with a doctor predicted counseling referral, whereas belief that family history influenced risk was the strongest BRCA testing predictor. Women perceiving their cancer risk as much higher than other women their age were twice as likely (95% confidence interval: 2.0-9.6) to report genetic counseling referral. Conclusion: In a health system with ready access to cancer genetic counseling and BRCA testing, women who were at high risk underutilized these services. There were strong associations between perceived ovarian cancer risk and genetic counseling referral, and between a belief that family history influenced risk and BRCA testing, C1 [Bellcross, Cecelia A.] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA. [Peipins, Lucy A.; Rodriguez, Juan L.; Hawkins, Nikki A.; Leadbetter, Steven] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Epidemiol & Appl Res Branch, Atlanta, GA USA. [McCarty, Frances A.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Off Publ Hlth Sci Serv, Atlanta, GA USA. [Alford, Sharon Hensley] Josephine Ford Canc Ctr, Detroit, MI USA. RP Bellcross, CA (reprint author), Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA. EM cbellcr@emory.edu FU Centers for Disease Control and Prevention [200-2002-00574, 0015] FX The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Funding support was provided by the Centers for Disease Control and Prevention (contract 200-2002-00574, task order 0015). NR 39 TC 4 Z9 4 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1098-3600 EI 1530-0366 J9 GENET MED JI Genet. Med. PD JAN PY 2015 VL 17 IS 1 BP 43 EP 50 DI 10.1038/gim.2014.68 PG 8 WC Genetics & Heredity SC Genetics & Heredity GA AY7MT UT WOS:000347744900007 PM 24946155 ER PT J AU Schully, SD Lam, TK Dotson, WD Chang, CQ Aronson, N Birkeland, ML Brewster, SJ Boccia, S Buchanan, AH Calonge, N Calzone, K Djulbegovic, B Goddard, KAB Klein, RD Klein, TE Lau, J Long, R Lyman, GH Morgan, RL Palmer, CGS Ling, MVR Rubinstein, WS Swen, JJ Terry, SF Williams, MS Khoury, MJ AF Schully, Sheri D. Lam, Tram Kim Dotson, W. David Chang, Christine Q. Aronson, Naomi Birkeland, Marian L. Brewster, Stephanie Jo Boccia, Stefania Buchanan, Adam H. Calonge, Ned Calzone, Kathleen Djulbegovic, Benjamin Goddard, Katrina A. B. Klein, Roger D. Klein, Teri E. Lau, Joseph Long, Rochelle Lyman, Gary H. Morgan, Rebecca L. Palmer, Christina G. S. Ling, Mary V. Re Rubinstein, Wendy S. Swen, Jesse J. Terry, Sharon F. Williams, Marc S. Khoury, Muin J. TI Evidence synthesis and guideline development in genomic medicine: current status and future prospects SO GENETICS IN MEDICINE LA English DT Article DE evidence synthesis; genomic medicine; guideline development ID INCIDENTAL FINDINGS; RECOMMENDATIONS; PHARMACOGENOMICS; CONSORTIUM; QUALITY; CANCER; ERA AB Purpose: With the accelerated implementation of genomic medicine, health-care providers will depend heavily on professional guidelines and recommendations. Because genomics affects many diseases across the life span, no single professional group covers the entirety of this rapidly developing field. Methods: To pursue a discussion of the minimal elements needed to develop evidence-based guidelines in genomics, the Centers for Disease Control and Prevention and the National Cancer Institute jointly held a workshop to engage representatives from 35 organizations with interest in genomics (13 of which make recommendations). The workshop explored methods used in evidence synthesis and guideline development and initiated a dialogue to compare these methods and to assess whether they are consistent with the Institute of Medicine report "Clinical Practice Guidelines We Can Trust." Results: The participating organizations that develop guidelines or recommendations all had policies to manage guideline development and group membership, and processes to address conflicts of interests. However, there was wide variation in the reliance on external reviews, regular updating of recommendations, and use of systematic reviews to assess the strength of scientific evidence. Conclusion: Ongoing efforts are required to establish criteria for guideline development in genomic medicine as proposed by the Institute of Medicine. C1 [Schully, Sheri D.; Lam, Tram Kim; Chang, Christine Q.; Khoury, Muin J.] NCI, Epidemiol & Genom Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Dotson, W. David; Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Gen, Atlanta, GA USA. [Aronson, Naomi] Blue Cross Blue Shield Assoc, Technol Evaluat Ctr, Chicago, IL USA. [Birkeland, Marian L.] Natl Comprehens Canc Network, Ft Washington, PA USA. [Brewster, Stephanie Jo] Boston Childrens Hosp, Boston, MA USA. [Boccia, Stefania] Univ Cattolica Sacro Cuore, Inst Publ Hlth, Sect Hyg, Rome, Italy. [Buchanan, Adam H.] Duke Canc Inst, Durham, NC USA. [Calonge, Ned] Colorado Trust, Denver, CO USA. [Calzone, Kathleen] NCI, Genet Branch, Ctr Canc Res, Bethesda, MD 20892 USA. [Djulbegovic, Benjamin] Univ S Florida, Tampa, FL USA. [Djulbegovic, Benjamin] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA. [Djulbegovic, Benjamin] Res Inst, Tampa, FL USA. [Goddard, Katrina A. B.] Kaiser Permanente NW, Portland, OR USA. [Klein, Roger D.] Cleveland Clin, Dept Mol Pathol, Cleveland, OH 44106 USA. [Klein, Teri E.] Stanford Univ, Dept Genet, Palo Alto, CA 94304 USA. [Lau, Joseph] Brown Univ, Providence, RI 02912 USA. [Long, Rochelle] Natl Inst Gen Med Sci, NIH, Bethesda, MD USA. [Lyman, Gary H.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Morgan, Rebecca L.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. [Palmer, Christina G. S.] Univ Calif Los Angeles, Los Angeles, CA USA. [Ling, Mary V. Re] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA. [Rubinstein, Wendy S.] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA. [Swen, Jesse J.] Leiden Univ, Med Ctr, Leiden, Netherlands. [Terry, Sharon F.] Genet Alliance, Washington, DC USA. [Williams, Marc S.] Genom Med Inst, Danville, PA USA. [Williams, Marc S.] Geisinger Hlth Syst, Genom Med Inst, Danville, PA USA. RP Schully, SD (reprint author), NCI, Epidemiol & Genom Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. EM schullys@mail.nih.gov RI Djulbegovic, Benjamin/I-3661-2012; OI Djulbegovic, Benjamin/0000-0003-0671-1447; Dotson, William David/0000-0002-9606-6594 FU National Institutes of Health [R24GM61374, U01GM 92666, U01HL 105198] FX The authors are grateful to all of the workshop participants, who fully engaged in the meeting discussions. In addition, the work presented here was partially supported by National Institutes of Health grants R24GM61374, U01GM 92666, and U01HL 105198. The findings and conclusions in this article are those of the authors and do not necessarily reflect the views of the Department of Health and Human Services. NR 18 TC 4 Z9 4 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1098-3600 EI 1530-0366 J9 GENET MED JI Genet. Med. PD JAN PY 2015 VL 17 IS 1 BP 63 EP 67 DI 10.1038/gim.2014.69 PG 5 WC Genetics & Heredity SC Genetics & Heredity GA AY7MT UT WOS:000347744900010 PM 24946156 ER PT J AU Whitehead, L AF Whitehead, LaToria TI The Road Towards Environmental Justice From a Multifaceted Lens SO JOURNAL OF ENVIRONMENTAL HEALTH LA English DT Editorial Material AB Editor's Note: NEHA strives to provide up-to-date and relevant information on environmental health and to build partnerships in the profession. In pursuit of these goals, we feature a column from the Environmental Health Services Branch (EHSB) of the Centers for Disease Control and Prevention (CDC) in every issue of the Journal. In this column, EHSB and guest authors from across CDC will highlight a variety of concerns, opportunities, challenges, and successes that we all share in environmental public health. EHSB's objective is to strengthen the role of state, local, tribal, and national environmental health programs and professionals to anticipate, identify, and respond to adverse environmental exposures and the consequences of these exposures for human health. The conclusions in this article are those of the author(s) and do not necessarily represent the views of CDC. LaToria Whitehead currently serves as the environmental justice officer of the Division of Emergency and Environmental Health Services at CDC's National Center for Environmental Health and is an adjunct professor in the political science department at Clark Atlanta University and Spelman College. C1 CDC, Natl Ctr Environm Hlth, Div Emergency & Environm Hlth Serv, Atlanta, GA 30341 USA. RP Whitehead, L (reprint author), CDC, Natl Ctr Environm Hlth, Div Emergency & Environm Hlth Serv, 4770 Buford Highway NE,Mailstop F-58, Atlanta, GA 30341 USA. EM lwhiteheadl@cdc.gov FU Intramural CDC HHS [CC999999] NR 3 TC 0 Z9 0 U1 1 U2 5 PU NATL ENVIRON HEALTH ASSOC PI DENVER PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA SN 0022-0892 J9 J ENVIRON HEALTH JI J. Environ. Health PD JAN-FEB PY 2015 VL 77 IS 6 SI SI BP 106 EP 108 PG 3 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AZ1MP UT WOS:000348003400016 PM 25619044 ER PT J AU Amman, BR Jones, MEB Sealy, TK Uebelhoer, LS Schuh, AJ Bird, BH Coleman-McCray, JD Martin, BE Nichol, ST Towner, JS AF Amman, Brian R. Jones, Megan E. B. Sealy, Tara K. Uebelhoer, Luke S. Schuh, Amy J. Bird, Brian H. Coleman-McCray, JoAnn D. Martin, Brock E. Nichol, Stuart T. Towner, Jonathan S. TI ORAL SHEDDING OF MARBURG VIRUS IN EXPERIMENTALLY INFECTED EGYPTIAN FRUIT BATS (ROUSETTUS AEGYPTIACUS) SO JOURNAL OF WILDLIFE DISEASES LA English DT Article DE Experimental infection; Marburg virus; Rousettus aegyptiacus; shedding; transmission ID HEMORRHAGIC-FEVER; ANTIBODY AB Marburg virus (Marburg marburgvirus; MARY) causes sporadic outbreaks of Marburg hemorrhagic fever (MHF) in Africa. The Egyptian fruit bat (Rousettus aegyptiacus) has been identified as a natural reservoir based most-recently on the repeated isolation of MARY directly from bats caught at two locations in southwestern Uganda where miners and tourists separately contracted MHF from 2007-08. Despite learning much about the ecology of MARY through extensive field investigations, there remained unanswered questions such as determining the primary routes of virus shedding and the severity of disease, if any, caused by MARY in infected bats. To answer these questions and others, we experimentally infected captive-bred R. aegyptiacus with MARY under high (biosafety level 4) containment. These experiments have shown infection profiles consistent with R. aegyptiacus being a bona fide natural reservoir host for MARY and demonstrated routes of viral shedding capable of infecting humans and other animals. C1 [Amman, Brian R.; Jones, Megan E. B.; Sealy, Tara K.; Uebelhoer, Luke S.; Schuh, Amy J.; Bird, Brian H.; Coleman-McCray, JoAnn D.; Martin, Brock E.; Nichol, Stuart T.; Towner, Jonathan S.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA 30333 USA. [Jones, Megan E. B.; Towner, Jonathan S.] Univ Georgia, Coll Vet Med, Athens, GA 30602 USA. RP Towner, JS (reprint author), Ctr Dis Control & Prevent, Viral Special Pathogens Branch, 1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM jit8@cdc.gov FU US Department of Health and Human Services FX We thank the Centers for Disease Control and Prevention's Animal Resource Branch for care and support of the bats during this study. We also thank B. R. Erickson for the photograph used in this publication and T. Klimova for editorial assistance. Funding for this study was provided by the US Department of Health and Human Services. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or Health and Human Services. NR 23 TC 23 Z9 24 U1 2 U2 25 PU WILDLIFE DISEASE ASSOC, INC PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0090-3558 EI 1943-3700 J9 J WILDLIFE DIS JI J. Wildl. Dis. PD JAN PY 2015 VL 51 IS 1 BP 113 EP 124 DI 10.7589/2014-08-198 PG 12 WC Veterinary Sciences SC Veterinary Sciences GA AZ1LS UT WOS:000348001200012 PM 25375951 ER PT J AU Olival, KJ Dittmar, K Bai, Y Rostal, MK Lei, BR Daszak, P Kosoy, M AF Olival, Kevin J. Dittmar, Katharina Bai, Ying Rostal, Melinda K. Lei, Bonnie R. Daszak, Peter Kosoy, Michael TI Bartonella spp. in a Puerto Rican Bat Community SO JOURNAL OF WILDLIFE DISEASES LA English DT Article DE Bacteria; Bartonella; bat; Chiroptera; diversity; host range; Puerto Rico; vector ID HOST-PARASITE; NYCTERIBIIDAE; SPECIFICITY; STREBLIDAE; RODENTS AB We captured and sampled 68 bats of six species from a shared roosting site in Puerto Rico in April 2012. Bats were screened for Bartonella spp. by culture and confirmed by PCR and sequencing for the gltA gene. Bartonella cultures were obtained from blood specimens of 9/51 (18%) individuals from three species (Artibeus jamaicensis, Brachyphylla cavernarum, and Monophyllus redmani). Phylogenetic analysis of the gltA sequences showed that M. redmani was infected with multiple, diverse Bartonella strains, and A. jamaicensis was infected with a strain related to a strain from a congeneric host. Ectoparasite load could possibly explain observed differences in Bartonella diversity and prevalence between bat species in this community, and we suggest future research to substantiate these preliminary findings. C1 [Olival, Kevin J.; Rostal, Melinda K.; Lei, Bonnie R.; Daszak, Peter] EcoHlth Alliance, New York, NY 10001 USA. [Dittmar, Katharina] SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14260 USA. [Bai, Ying; Kosoy, Michael] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Lei, Bonnie R.] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA. RP Olival, KJ (reprint author), EcoHlth Alliance, 460 W 34th St, New York, NY 10001 USA. EM olival@ecohealthalliance.org FU National Institutes of Health National Institute of Allergy and Infectious Diseases [1R01 AI079231-01]; Centers for Disease Control and Prevention's Global Disease Detection Program; US Agency for International Development's Emerging Pandemic Threats Program PREDICT project [GHN-A-OO-09-00010-00] FX We thank Solon Morse and Krishna Balasubramaniam for field assistance. Funding provided in part by a National Institutes of Health National Institute of Allergy and Infectious Diseases non-biodefense Award (1R01 AI079231-01), the Centers for Disease Control and Prevention's Global Disease Detection Program, and the US Agency for International Development's Emerging Pandemic Threats Program PREDICT project (GHN-A-OO-09-00010-00). NR 20 TC 5 Z9 5 U1 2 U2 10 PU WILDLIFE DISEASE ASSOC, INC PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0090-3558 EI 1943-3700 J9 J WILDLIFE DIS JI J. Wildl. Dis. PD JAN PY 2015 VL 51 IS 1 BP 274 EP 278 DI 10.7589/2014-04-113 PG 5 WC Veterinary Sciences SC Veterinary Sciences GA AZ1LS UT WOS:000348001200034 PM 25380361 ER PT J AU Rodgers, L Pabst, LJ Chaves, SS AF Rodgers, Loren Pabst, Laura J. Chaves, Sandra S. TI Increasing uptake of live attenuated influenza vaccine among children in the United States, 2008-2014 SO VACCINE LA English DT Article DE Immunization information systems; Registries; Vaccine coverage; Vaccination; Influenza vaccines; Influenza, Human; Child, Preschool ID SEASONAL INFLUENZA; YOUNG-CHILDREN; COVERAGE AB The Advisory Committee on Immunization Practices (ACIP) recommends annual influenza vaccination for all persons in the United States aged >= 6 months. On June 25, 2014, ACIP preferentially recommended live attenuated influenza vaccine (LAIV) for healthy children aged 2-8 years [1]. Little is known about national LAIV uptake. To determine uptake of LAIV relative to inactivated influenza vaccine, we analyzed vaccination records from six immunization information system sentinel sites (approximately 10% of US population). LAIV usage increased over time in all sites. Among children 2-8 years of age vaccinated for influenza, exclusive LAIV usage in the collective sentinel site area increased from 20.1% (2008-09 season) to 38.0% (2013-14). During 2013-14, at least half of vaccinated children received LAIV in Minnesota (50.0%) and North Dakota (55.5%). Increasing LAIV usage suggests formulation acceptability, and this preexisting trend offers a favorable context for implementation of ACIP's preferential recommendation. Published by Elsevier Ltd. C1 [Rodgers, Loren; Pabst, Laura J.] Ctr Dis Control & Prevent, Immunizat Informat Syst Support Branch, Immunizat Serv Div, Atlanta, GA 30333 USA. [Chaves, Sandra S.] Ctr Dis Control & Prevent, Epidemiol & Preparedness Branch, Influenza Div, Atlanta, GA 30333 USA. RP Rodgers, L (reprint author), Ctr Dis Control & Prevent, Immunizat Informat Syst Support Branch, Immunizat Serv Div, 1600 Clifton Rd NE,Mailstop A-19, Atlanta, GA 30333 USA. EM lrodgers@cdc.gov NR 10 TC 9 Z9 9 U1 1 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 1 PY 2015 VL 33 IS 1 BP 22 EP 24 DI 10.1016/j.vaccine.2014.11.006 PG 3 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AY6FX UT WOS:000347663700008 PM 25448098 ER PT J AU Monath, TP Seligman, SJ Robertson, JS Guy, B Hayes, EB Condit, RC Excler, JL Mac, LM Carbery, B Chen, RT AF Monath, Thomas P. Seligman, Stephen J. Robertson, James S. Guy, Bruno Hayes, Edward B. Condit, Richard C. Excler, Jean Louis Mac, Lisa Marie Carbery, Baevin Chen, Robert T. CA Brighton Collaboration Viral TI Live virus vaccines based on a yellow fever vaccine backbone: Standardized template with key considerations for a risk/benefit assessment SO VACCINE LA English DT Article DE Vaccines; Yellow fever vaccine; Viral vector; Brighton Collaboration; Risk/benefit assessment; Vaccine safety ID WEST-NILE-VIRUS; TETRAVALENT DENGUE VACCINE; JAPANESE ENCEPHALITIS-VIRUS; SERIOUS ADVERSE EVENTS; AEDES-AEGYPTI MOSQUITOS; FLAVIVIRUS-NAIVE ADULTS; ATTENUATED VACCINE; NONHUMAN-PRIMATES; VISCEROTROPIC DISEASE; CHIMERIVAX-JE AB The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety of live, recombinant viral vaccines incorporating genes from heterologous viruses inserted into the backbone of another virus (so-called "chimeric virus vaccines"). Many viral vector vaccines are in advanced clinical trials. The first such vaccine to be approved for marketing (to date in Australia, Thailand, Malaysia, and the Philippines) is a vaccine against the flavivirus, Japanese encephalitis (JE), which employs a licensed vaccine (yellow fever 17D) as a vector. In this vaccine, two envelope proteins (prM-E) of YF 17D virus were exchanged for the corresponding genes of JE virus, with additional attenuating mutations incorporated into the JE gene inserts. Similar vaccines have been constructed by inserting prM-E genes of dengue and West Nile into YF 17D virus and are in late stage clinical studies. The dengue vaccine is, however, more complex in that it requires a mixture of four live vectors each expressing one of the four dengue serotypes. This vaccine has been evaluated in multiple clinical trials. No significant safety concerns have been found. The Phase 3 trials met their endpoints in terms of overall reduction of confirmed dengue fever, and, most importantly a significant reduction in severe dengue and hospitalization due to dengue. However, based on results that have been published so far, efficacy in preventing serotype 2 infection is less than that for the other three serotypes. In the development of these chimeric vaccines, an important series of comparative studies of safety and efficacy were made using the parental YF 17D vaccine virus as a benchmark. In this paper, we use a standardized template describing the key characteristics of the novel flavivirus vaccine vectors, in comparison to the parental YF 17D vaccine. The template facilitates scientific discourse among key stakeholders by increasing the transparency and comparability of information. The Brighton Collaboration V3SWG template may also be useful as a guide to the evaluation of other recombinant viral vector vaccines. (C) 2014 Published by Elsevier Ltd. C1 [Monath, Thomas P.] Kleiner Perkins Caufield & Byers, Menlo Pk, CA 94025 USA. [Seligman, Stephen J.] New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA. [Robertson, James S.] Natl Inst Biol Stand & Controls, Potters Bar EN6 3QG, Herts, England. [Guy, Bruno] Sanofi Pasteur, Discovery Dept, F-69280 Marcy Letoile, France. [Hayes, Edward B.] Barcelona Ctr Int Hlth Res CRESIB, Barcelona 08036, Spain. [Condit, Richard C.] Univ Florida, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA. [Excler, Jean Louis] IAVI, New York, NY 10004 USA. [Excler, Jean Louis] US Mil HIV Res Program MHRP, Bethesda, MD 20817 USA. [Mac, Lisa Marie; Carbery, Baevin; Chen, Robert T.] Ctr Dis Control & Prevent CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. RP Seligman, SJ (reprint author), New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA. EM stephen_seligman@nymc.edu FU Intramural CDC HHS [CC999999] NR 92 TC 16 Z9 16 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 1 PY 2015 VL 33 IS 1 BP 62 EP 72 DI 10.1016/j.vaccine.2014.10.004 PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AY6FX UT WOS:000347663700012 PM 25446819 ER PT J AU Chen, RT Carbery, B Mac, L Berns, KI Chapman, L Condit, RC Excler, JL Gurwith, M Hendry, M Khan, AS Khuri-Bulos, N Klug, B Robertson, JS Seligman, SJ Sheets, R Williamson, AL AF Chen, Robert T. Carbery, Baevin Mac, Lisa Berns, Kenneth I. Chapman, Louisa Condit, Richard C. Excler, Jean-Louis Gurwith, Marc Hendry, Michael Khan, Arifa S. Khuri-Bulos, Najwa Klug, Bettina Robertson, James S. Seligman, Stephen J. Sheets, Rebecca Williamson, Anna-Lise CA V3SWG TI The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) SO VACCINE LA English DT Article DE Vaccines; Viral Vector; Safety; Immunization ID ROTAVIRUS VACCINE; HIV-1 VACCINE; DOUBLE-BLIND; RISK; EFFICACY; IMMUNIZATION; INFECTION; TRIAL; STEP; H1N1 AB Recombinant viral vectors provide an effective means for heterologous antigen expression in vivo and thus represent promising platforms for developing novel vaccines against human pathogens from Ebola to tuberculosis. An increasing number of candidate viral vector vaccines are entering human clinical trials. The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to improve our ability to anticipate potential safety issues and meaningfully assess or interpret safety data, thereby facilitating greater public acceptance when licensed. Published by Elsevier Ltd. C1 [Chen, Robert T.; Carbery, Baevin; Mac, Lisa; Chapman, Louisa; Hendry, Michael] Ctr Dis Control & Prevent, DHAP, NCHHSTP, Atlanta, GA 30333 USA. [Carbery, Baevin] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA. [Berns, Kenneth I.; Condit, Richard C.] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA. [Excler, Jean-Louis] Int AIDS Vaccine Initiat, New York, NY USA. US Mil HIV Res Program MHRP, Bethesda, MD 20817 USA. [Gurwith, Marc] PaxVax, San Diego, CA 92121 USA. [Khan, Arifa S.] US FDA, Lab Retroviruses, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA. [Khuri-Bulos, Najwa] Jordan Univ Hosp, Div Infect Dis, Amman, Jordan. [Klug, Bettina] Paul Ehrlich Inst, D-63225 Langen, Germany. [Robertson, James S.] Natl Inst Biol Stand & Controls, Potters Bar EN6 3QG, Herts, England. [Seligman, Stephen J.] New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA. [Sheets, Rebecca] NIAID, Div Aids, US Natl Inst Hlth, Bethesda, MD 20892 USA. [Williamson, Anna-Lise] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa. [Williamson, Anna-Lise] Natl Hlth Lab Serv, Cape Town, South Africa. RP Chen, RT (reprint author), Ctr Dis Control & Prevent, DHAP, NCHHSTP, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM brightoncollaborationv3swg@gmail.com FU Intramural CDC HHS [CC999999] NR 35 TC 5 Z9 5 U1 2 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 1 PY 2015 VL 33 IS 1 BP 73 EP 75 DI 10.1016/j.vaccine.2014.09.035 PG 3 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AY6FX UT WOS:000347663700013 PM 25305565 ER PT J AU Belongia, EA Sundaram, ME McClure, DL Meece, JK Ferdinands, J VanWormer, JJ AF Belongia, Edward A. Sundaram, Maria E. McClure, David L. Meece, Jennifer K. Ferdinands, Jill VanWormer, Jeffrey J. TI Waning vaccine protection against influenza A (H3N2) illness in children and older adults during a single season SO VACCINE LA English DT Article DE Influenza; Influenza vaccine; Immunity; Vaccine effectiveness ID EFFICACY; IMMUNIZATION; ANTIBODY AB Background: Recent studies have suggested that vaccine-induced protection against influenza may decline within one season. We reanalyzed data from a study of influenza vaccine effectiveness to determine if time since vaccination was an independent predictor of influenza A (H3N2). Methods: Patients with acute respiratory illness were actively recruited during the 2007-2008 season. Respiratory swabs were tested for influenza, and vaccination dates were determined by a validated immunization registry. The association between influenza RT-PCR result and vaccination interval (days) was examined using multivariable logistic regression, adjusting for calendar time, age and other confounders. Results: There were 629 vaccinated participants, including 177 influenza A (H3N2) cases and 452 test negative controls. The mean (SD) interval from vaccination to illness onset was 101.7 (25.9) days for influenza cases and 93.0 (29.9) days for controls. There was a significant association between vaccination interval and influenza result in the main effects model. The adjusted odds ratio (a0R) for influenza was 1.12 (CI 1.01, 1.26) for every 14 day increase in the vaccination interval. Age modified the association between vaccination interval and influenza (p = 0.005 for interaction). Influenza was associated with increasing vaccination interval in young children and older adults, but not in adolescents or non-elderly adults. Similar results were found when calendar week of vaccine receipt was assessed as the primary exposure variable. Conclusions: Identification of influenza A (H3N2) was associated with increasing time since vaccination among young children and older adults during a single influenza season. (C) 2014 The Authors. Published by Elsevier Ltd. C1 [Belongia, Edward A.; Sundaram, Maria E.; McClure, David L.; Meece, Jennifer K.; VanWormer, Jeffrey J.] Marshfield Clin Res Fdn, Marshfield, WI 54449 USA. [Ferdinands, Jill] US Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Ferdinands, Jill] Battelle Mem Inst, Atlanta, GA USA. RP Belongia, EA (reprint author), Marshfield Clin Res Fdn, 1000 North Oak Ave, Marshfield, WI 54449 USA. EM belongia.edward@marshfieldclinic.org FU cooperative agreement from the U.S. Centers for Disease Control and Prevention [5U01IP000471] FX This research was funded by a cooperative agreement from the U.S. Centers for Disease Control and Prevention (5U01IP000471). The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. NR 18 TC 19 Z9 19 U1 1 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X EI 1873-2518 J9 VACCINE JI Vaccine PD JAN 1 PY 2015 VL 33 IS 1 BP 246 EP 251 DI 10.1016/j.vaccine.2014.06.052 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA AY6FX UT WOS:000347663700037 PM 24962752 ER PT J AU Morand, S Jittapalapong, S Kosoy, M AF Morand, S. Jittapalapong, S. Kosoy, Michael TI Rodents as Hosts of Infectious Diseases: Biological and Ecological Characteristics INTRODUCTION SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Editorial Material C1 [Morand, S.] Ctr Infectiol Christophe Merieux Laos, CNRS CIRAD AGIRs, Viangchan, Laos. [Jittapalapong, S.] Kasetsart Univ, Dept Parasitol, Fac Vet Med, Bangkok, Thailand. [Kosoy, Michael] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. RP Morand, S (reprint author), CICML, CIRAD, Viangchan, Laos. EM serge.morand@univ-montp2.fr OI Morand, Serge/0000-0003-3986-7659 NR 9 TC 2 Z9 2 U1 3 U2 11 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JAN 1 PY 2015 VL 15 IS 1 SI SI BP 1 EP 2 DI 10.1089/vbz.2015.15.1.intro PG 2 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AZ9YM UT WOS:000348570600001 PM 25629774 ER PT J AU Kosoy, M Khlyap, L Cosson, JF Morand, S AF Kosoy, Michael Khlyap, Lyudmila Cosson, Jean-Francois Morand, Serge TI Aboriginal and Invasive Rats of Genus Rattus as Hosts of Infectious Agents SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Rattus; Ecology; Rat-borne infections; Old World rats; Taxonomic revisions ID HEPATITIS-E VIRUS; NORWAY RATS; LEPTOSPIRA-INTERROGANS; SMALL MAMMALS; BARTONELLA SPP.; UNITED-STATES; WILD RATS; GENETIC-CHARACTERIZATION; HANTAVIRUS INFECTION; WIDESPREAD INFECTION AB From the perspective of ecology of zoonotic pathogens, the role of the Old World rats of the genus Rattus is exceptional. The review analyzes specific characteristics of rats that contribute to their important role in hosting pathogens, such as host-pathogen relations and rates of rat-borne infections, taxonomy, ecology, and essential factors. Specifically the review addresses recent taxonomic revisions within the genus Rattus that resulted from applications of new genetic tools in understanding relationships between the Old World rats and the infectious agents that they carry. Among the numerous species within the genus Rattus, only three species-the Norway rat (R. norvegicus), the black or roof rat (R. rattus), and the Asian black rat (R. tanezumi)-have colonized urban ecosystems globally for a historically long period of time. The fourth invasive species, R. exulans, is limited to tropical Asia-Pacific areas. One of the points highlighted in this review is the necessity to discriminate the roles played by rats as pathogen reservoirs within the land of their original diversification and in regions where only one or few rat species were introduced during the recent human history. C1 [Kosoy, Michael] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Khlyap, Lyudmila] Severtsov Inst Ecol & Evolut, Moscow, Russia. [Cosson, Jean-Francois] INRA, CBGP, UMR1062, F-34988 Montferrier Sur Lez, France. [Morand, Serge] Univ Montpellier, CNRS, Inst Sci Evolut, Montpellier, France. RP Kosoy, M (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. EM mck3@cdc.gov OI Khlyap, Liudmila/0000-0001-7698-5887; Cosson, Jean Francois/0000-0003-0863-5871 NR 97 TC 8 Z9 8 U1 1 U2 16 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JAN 1 PY 2015 VL 15 IS 1 SI SI BP 3 EP 12 DI 10.1089/vbz.2014.1629 PG 10 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AZ9YM UT WOS:000348570600002 PM 25629775 ER PT J AU Himsworth, CG Bai, Y Kosoy, MY Wood, H DiBernardo, A Lindsay, R Bidulka, J Tang, P Jardine, C Patrick, D AF Himsworth, Chelsea G. Bai, Ying Kosoy, Michael Y. Wood, Heidi DiBernardo, Antonia Lindsay, Robbin Bidulka, Julie Tang, Patrick Jardine, Claire Patrick, David TI An Investigation of Bartonella spp., Rickettsia typhi, and Seoul Hantavirus in Rats (Rattus spp.) from an Inner-City Neighborhood of Vancouver, Canada: Is Pathogen Presence a Reflection of Global and Local Rat Population Structure? SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Urban; Rattus spp.; Rickettsia typhi; Seoul hantavirus; Zoonotic disease; Rat; Bartonella spp. ID NORWAY RATS; MURINE TYPHUS; LEPTOSPIRA-INTERROGANS; SMALL MAMMALS; VIRUS; NORVEGICUS; INFECTION; RODENTS; PREVALENCE; EPIDEMIOLOGY AB Urban Norway and black rats (Rattus norvegicus and Rattus rattus) are reservoirs for variety of zoonotic pathogens. Many of these pathogens, including Rickettsia typhi, Bartonella spp., and Seoul hantavirus (SEOV), are thought to be endemic in rat populations worldwide; however, past field research has found these organisms to be absent in certain rat populations. Rats (Rattus spp.) from an inner city neighborhood of Vancouver, Canada, were tested for exposure to and/or infection with SEOV and R. typhi (using serology and PCR), as well as Bartonella spp. (using culture and sequencing). Approximately 25% of 404 rats tested were infected with Bartonella tribocorum, which demonstrated significant geographic clustering within the study area. Infection was associated with both season and sexual maturity. Seroreactivity against R. typhi and SEOV was observed in 0.36% and 1.45% of 553 rats tested, respectively, although PCR screening results for these pathogens were negative, suggesting that they are not endemic in the study population. Overall, these results suggest that the geographic distribution of rat-associated zoonoses, including R. typhi, SEOV, and Bartonella spp., is less ubiquitous than previously appreciated, and is likely dependent on patterns of dispersion and establishment of the rat reservoir host. Further study on global and local Rattus spp. population structures may help to elucidate the ecology of zoonotic organisms in these species. C1 [Himsworth, Chelsea G.; Patrick, David] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V5Z 1M9, Canada. [Himsworth, Chelsea G.; Bidulka, Julie] British Columbia Minist Agr, Ctr Anim Hlth, Abbotsford, BC, Canada. [Bai, Ying; Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. [Wood, Heidi; DiBernardo, Antonia; Lindsay, Robbin] Publ Hlth Agcy Canada, Natl Microbiol Lab, Zoonot Dis & Special Pathogens, Winnipeg, MB, Canada. [Tang, Patrick] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada. [Tang, Patrick] British Columbia Ctr Dis Control, Vancouver, BC, Canada. [Jardine, Claire] Univ Guelph, Dept Pathobiol, Guelph, ON N1G 2W1, Canada. RP Himsworth, CG (reprint author), Ctr Anim Hlth, 1767 Angus Campbell Rd, Abbotsford, BC V3G 2M3, Canada. EM cgh050@mail.ubc.ca OI Tang, Patrick/0000-0003-1583-5484 FU Canadian Institutes of Health Research [MOP-119530, CGV-104833]; British Columbia Centre for Disease Control; Urban Health Research Initiative; Vancouver Injection Drug User Study FX This study was supported by the Canadian Institutes of Health Research (MOP-119530 and CGV-104833). We would like to thank the City of Vancouver (Mr. M. Wightman and Mr. S. McMillan), the British Columbia Centre for Disease Control, the Urban Health Research Initiative, and the Vancouver Injection Drug User Study for supporting the study. Field collection of rats was made possible by the assistance of the Vancouver Area Network of Drug Users, Alice Feng, and Kirbee Parsons. NR 40 TC 2 Z9 2 U1 1 U2 10 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JAN 1 PY 2015 VL 15 IS 1 SI SI BP 21 EP 26 DI 10.1089/vbz.2014.1657 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA AZ9YM UT WOS:000348570600004 PM 25629777 ER PT J AU Kugeler, KJ Staples, JE Hinckley, AF Gage, KL Mead, PS AF Kugeler, Kiersten J. Staples, J. Erin Hinckley, Alison F. Gage, Kenneth L. Mead, Paul S. TI Epidemiology of Human Plague in the United States, 1900-2012 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID NEW-MEXICO; BUBONIC PLAGUE; RISK-FACTORS; CLINICAL FEATURES; YERSINIA-PESTIS; INFECTIONS; USA AB We summarize the characteristics of 1,006 cases of human plague occurring in the United States over 113 years, beginning with the first documented case in 1900. Three distinct eras can be identified on the basis of the frequency, nature, and geographic distribution of cases. During 1900-1925, outbreaks were common but were restricted to populous port cities. During 192671964, the geographic range of disease expanded rapidly, while the total number of reported cases fell. During 1965-2012, sporadic cases occurred annually, primarily in the rural Southwest. Clinical and demographic features of human illness have shifted over time as the disease has moved from crowded cities to the rural West. These shifts reflect changes in the populations at risk, the advent of antibiotics, and improved detection of more clinically indistinct forms of infection. Overall, the emergence of human plague in the United States parallels observed patterns of introduction of exotic plants and animals. C1 [Staples, J. Erin; Hinckley, Alison F.; Gage, Kenneth L.; Mead, Paul S.] Ctr Dis Control & Prevent, Ft Collins, CO 80521 USA. [Kugeler, Kiersten J.] Ctr Dis Control & Prevent, Bacterial Dis Branch, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Kugeler, KJ (reprint author), Ctr Dis Control & Prevent, Mailstop PO2,3156 Rampart Rd, Ft Collins, CO 80521 USA. EM kkugeler@cdc.gov NR 40 TC 12 Z9 13 U1 4 U2 47 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2015 VL 21 IS 1 BP 16 EP 22 DI 10.3201/eid2101.140564 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AY3SW UT WOS:000347503700003 PM 25529546 ER PT J AU Conger, NG Paolino, KM Osborn, EC Rusnak, JM Gunther, S Pool, J Rollin, PE Allan, PF Schmidt-Chanasit, J Rieger, T Kortepeter, MG AF Conger, Nicholas G. Paolino, Kristopher M. Osborn, Erik C. Rusnak, Janice M. Guenther, Stephan Pool, Jane Rollin, Pierre E. Allan, Patrick F. Schmidt-Chanasit, Jonas Rieger, Toni Kortepeter, Mark G. TI Health Care Response to CCHF in US Soldier and Nosocomial Transmission to Health Care Providers, Germany, 2009 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID CONGO HEMORRHAGIC-FEVER; SERUM-LEVELS; VIRAL LOAD; VIRUS; ACTIVATION; TURKEY; CELLS; PATHOGENESIS; INTERFERON; PROGNOSIS AB In 2009, a lethal case of Crimean Congo hemorrhagic fever (CCHF), acquired by a US soldier in Afghanistan, was treated at a medical center in Germany and resulted in nosocomial transmission to 2 health care providers (HCPs). After his arrival at the medical center (day 6 of illness) by aeromedical evacuation, the patient required repetitive bronchoscopies to control severe pulmonary hemorrhage and renal and hepatic dialysis for hepatorenal failure. After showing clinical improvement, the patient died suddenly on day 11 of illness from cerebellar tonsil herniation caused by cerebral/cerebellar edema. The 2 infected HCPs were among 16 HCPs who received ribavirin postexposure prophylaxis. The infected HCPs had mild or no CCHF symptoms. Transmission may have occurred during bag-valve-mask ventilation, breaches in personal protective equipment during resuscitations, or bronchoscopies generating infectious aerosols. This case highlights the critical care and infection control challenges presented by severe CCHF cases, including the need for experience with ribavirin treatment and postexposure prophylaxis. C1 [Conger, Nicholas G.; Osborn, Erik C.; Pool, Jane; Allan, Patrick F.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Paolino, Kristopher M.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Rusnak, Janice M.] Force Hlth Protect, Ft Detrick, MD USA. [Guenther, Stephan; Schmidt-Chanasit, Jonas; Rieger, Toni] Bernhard Nocht Inst Trop Med, D-20359 Hamburg, Germany. [Rollin, Pierre E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Kortepeter, Mark G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Conger, NG (reprint author), Wright Patterson Med Ctr, 4881 Sugar Maple Dr, Wright Patterson AFB, OH 45433 USA. EM nicholas.conger@us.af.mil NR 40 TC 15 Z9 16 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2015 VL 21 IS 1 BP 23 EP 31 DI 10.3201/eid2101.141413 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AY3SW UT WOS:000347503700004 PM 25529825 ER PT J AU Mungai, EA Behravesh, CB Gould, LH AF Mungai, Elisabeth A. Behravesh, Casey Barton Gould, L. Hannah TI Increased Outbreaks Associated with Nonpasteurized Milk, United States, 2007-2012 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID UNPASTEURIZED MILK; RAW-MILK AB The number of US outbreaks caused by nonpasteurized milk increased from 30 during 2007-2009 to 51 during 2010-2012. Most outbreaks were caused by Campylobacter spp. (77%) and by nonpasteurized milk purchased from states in which nonpasteurized milk sale was legal (81%). Regulations to prevent distribution of nonpasteurized milk should be enforced. C1 [Mungai, Elisabeth A.] Atlanta Res & Educ Fdn, Atlanta, GA USA. [Mungai, Elisabeth A.; Behravesh, Casey Barton; Gould, L. Hannah] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Mungai, EA (reprint author), 1600 Clifton Rd NE,Mailstop C09, Atlanta, GA 30329 USA. EM emungai@cdc.gov; lgould@cdc.gov NR 9 TC 7 Z9 8 U1 1 U2 21 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2015 VL 21 IS 1 BP 119 EP 122 DI 10.3201/eid2101.140447 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AY3SW UT WOS:000347503700021 PM 25531403 ER PT J AU Okomo-Adhiambo, M Fry, AM Su, S Nguyen, HT Abd Elal, A Negron, E Hand, J Garten, RJ Barnes, J Xu, XY Villanueva, JM Gubareva, LV AF Okomo-Adhiambo, Margaret Fry, Alicia M. Su, Su Nguyen, Ha T. Abd Elal, Anwar Negron, Elizabeth Hand, Julie Garten, Rebecca J. Barnes, John Xu Xiyan Villanueva, Julie M. Gubareva, Larisa V. CA 2013-14 US Influenza Antiviral TI Oseltamivir-Resistant Influenza A(H1N1) pdm09 Viruses, United States, 2013-14 SO EMERGING INFECTIOUS DISEASES LA English DT Article ID PANDEMIC H1N1 2009 AB We report characteristics of oseltamivir-resistant influenza A(H1N1)pdm09 viruses and patients infected with these viruses in the United States. During 2013-14, fifty-nine (1.2%) of 4,968 analyzed US influenza A(H1N1)pdm09 viruses had the H275Y oseltamivir resistance conferring neuraminidase substitution. Our results emphasize the need for local surveillance for neuraminidase inhibitor susceptibility among circulating influenza viruses. C1 [Fry, Alicia M.; Su, Su; Nguyen, Ha T.; Abd Elal, Anwar; Garten, Rebecca J.; Barnes, John; Xu Xiyan; Villanueva, Julie M.; Gubareva, Larisa V.] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Okomo-Adhiambo, Margaret] Ctr Dis Control & Prevent, Virol Surveillance & Diag Branch, Influenza Div, Atlanta, GA 30329 USA. [Su, Su] Atlanta Res & Educ Fdn, Atlanta, GA USA. [Nguyen, Ha T.; Abd Elal, Anwar] Battelle Mem Inst, Atlanta, GA USA. [Negron, Elizabeth] Penn Dept Hlth, Harrisburg, PA 17108 USA. [Hand, Julie] Louisiana Off Publ Hlth, New Orleans, LA USA. RP Gubareva, LV (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G16, Atlanta, GA 30329 USA. EM lqg3@cdc.gov RI Cooks, R/G-1051-2015 OI Cooks, R/0000-0002-9581-9603 NR 14 TC 14 Z9 15 U1 1 U2 7 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2015 VL 21 IS 1 BP 136 EP 141 DI 10.3201/eid2101.141006 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AY3SW UT WOS:000347503700026 PM 25532050 ER PT J AU Gruszynski, K Young, A Levine, SJ Garvin, JP Brown, S Turner, L Fritzinger, A Gertz, RE Murphy, JM Vogt, M Beall, B AF Gruszynski, Karen Young, Andrea Levine, Seth J. Garvin, Joseph P. Brown, Susan Turner, Lauren Fritzinger, Angela Gertz, Robert E., Jr. Murphy, Julia M. Vogt, Marshall Beall, Bernard TI Streptococcus equi subsp zooepidemicus Infections Associated with Guinea Pigs SO EMERGING INFECTIOUS DISEASES LA English DT Article ID FIELD GEL-ELECTROPHORESIS AB Streptococcus equi subsp. zooepidemicus is a known zoonotic pathogen. In this public health investigation conducted in Virginia, USA, in 2013, we identified a probable family cluster of S. zooepidemicus cases linked epidemiologically and genetically to infected guinea pigs. S. zooepidemicus infections should be considered in patients who have severe clinical illness and report guinea pig exposure. C1 [Gruszynski, Karen; Levine, Seth J.; Murphy, Julia M.] Virginia Dept Hlth, Richmond, VA 23219 USA. [Young, Andrea] Virginia Dept Hlth, Manassas, VA USA. [Garvin, Joseph P.; Brown, Susan] Virginia Dept Agr & Consumer Serv, Richmond, VA USA. [Turner, Lauren; Fritzinger, Angela] Dept Gen Serv, Richmond, VA USA. [Gertz, Robert E., Jr.; Beall, Bernard] Ctr Dis Control & Prevent, Atlanta, GA USA. [Vogt, Marshall] Virginia Dept Hlth, Chesterfield, VA USA. [Vogt, Marshall] Chippenham Johnston Willis Med Ctr, Richmond, VA USA. RP Gruszynski, K (reprint author), Virginia Dept Hlth, Off Epidemiol, 109 Governor St, Richmond, VA 23219 USA. EM karen.gruszynski@vdh.virginia.gov NR 9 TC 5 Z9 5 U1 1 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2015 VL 21 IS 1 BP 156 EP 158 DI 10.3201/eid2101.140640 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AY3SW UT WOS:000347503700031 PM 25531424 ER PT J AU Edison, LS Dishman, HO Tobin-D'Angelo, MJ Allen, CR Guh, AY Drenzek, CL AF Edison, Laura S. Dishman, Hope O. Tobin-D'Angelo, Melissa J. Allen, C. Richard Guh, Alice Y. Drenzek, Cherie L. TI Endophthalmitis Outbreak Associated with Repackaged Bevacizumab SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID STREPTOCOCCUS ENDOPHTHALMITIS; INTRAVITREAL INJECTION; GRANULICATELLA C1 [Edison, Laura S.; Guh, Alice Y.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Edison, Laura S.; Dishman, Hope O.; Tobin-D'Angelo, Melissa J.; Guh, Alice Y.; Drenzek, Cherie L.] Georgia Dept Publ Hlth, Atlanta, GA 30303 USA. [Allen, C. Richard] Georgia Drug & Narcot Agcy, Atlanta, GA USA. RP Edison, LS (reprint author), Georgia Dept Publ Hlth, Acute Dis Epidemiol Sect, 2 Peachtree St NW,Suite 14-232, Atlanta, GA 30303 USA. EM kgq2@cdc.gov NR 10 TC 1 Z9 1 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2015 VL 21 IS 1 BP 171 EP 173 DI 10.3201/eid2101.141040 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AY3SW UT WOS:000347503700039 PM 25531168 ER PT J AU Harris, AM Yazzie, D Antone-Nez, R Dine-Chacon, G Kinlacheeny, JB Foley, D Yasmin, S Adams, L Livar, E Terranella, A Yeager, L Komatsu, K Van Beneden, C Langley, G AF Harris, Aaron M. Yazzie, Del Antone-Nez, Ramona Dine-Chacon, Gayle Kinlacheeny, J. B. Foley, David Yasmin, Seema Adams, Laura Livar, Eugene Terranella, Andrew Yeager, Linda Komatsu, Ken Van Beneden, Chris Langley, Gayle TI Community-Acquired Invasive GAS Disease among Native Americans, Arizona, USA, Winter 2013 SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID A STREPTOCOCCAL DISEASE; EPIDEMIOLOGY C1 [Harris, Aaron M.; Yasmin, Seema; Adams, Laura; Van Beneden, Chris; Langley, Gayle] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Yazzie, Del; Antone-Nez, Ramona; Dine-Chacon, Gayle; Kinlacheeny, J. B.; Foley, David] Navajo Div Hlth, Window Rock, AZ USA. [Livar, Eugene; Komatsu, Ken] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA. [Terranella, Andrew; Yeager, Linda] Indian Hlth Serv, Navajo Area, AZ USA. RP Harris, AM (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,Mailstop G37, Atlanta, GA 30329 USA. EM ieo9@cdc.gov NR 8 TC 1 Z9 1 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2015 VL 21 IS 1 BP 177 EP 179 DI 10.3201/eid2101.141148 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AY3SW UT WOS:000347503700042 PM 25531562 ER PT J AU Breedlove, B AF Breedlove, Byron TI Delicacy and Durability: The Microbiological Sublime SO EMERGING INFECTIOUS DISEASES LA English DT Editorial Material C1 [Breedlove, Byron] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. RP Breedlove, B (reprint author), Ctr Dis Control & Prevent, EID Journal, 1600 Clifton Rd NE,Mailstop C12, Atlanta, GA 30329 USA. EM wbb1@cdc.gov OI Breedlove, Byron/0000-0002-1026-1963 NR 4 TC 0 Z9 0 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 EI 1080-6059 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JAN PY 2015 VL 21 IS 1 BP 190 EP 191 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AY3SW UT WOS:000347503700049 ER PT J AU Norton, DM Brown, LG Frick, R Carpenter, LR Green, AL Tobin-D'Angelo, M Reimann, DW Blade, H Nicholas, DC Egan, JS Everstine, K AF Norton, D. M. Brown, L. G. Frick, R. Carpenter, L. R. Green, A. L. Tobin-D'Angelo, M. Reimann, D. W. Blade, H. Nicholas, D. C. Egan, J. S. Everstine, K. TI Managerial Practices regarding Workers Working while III SO JOURNAL OF FOOD PROTECTION LA English DT Article AB Surveillance data indicate that handling of food by an ill worker is a cause of almost half of all restaurant-related outbreaks. The U.S. Food and Drug Administration (FDA) Food Code contains recommendations for food service establishments, including restaurants, aimed at reducing the frequency with which food workers work while ill. However, few data exist on the extent to which restaurants have implemented FDA recommendations. The Centers for Disease Control and Prevention's Environmental Health Specialists Network (EHS-Net) conducted a study on the topic of ill food workers in restaurants. We interviewed restaurant managers (n = 426) in nine EHS-Net sites. We found that many restaurant policies concerning ill food workers do not follow FDA recommendations. For example, one-third of the restaurants' policies did not specifically address the circumstances under which ill food workers should be excluded from work (i.e., not be allowed to work). We also found that, in many restaurants, managers are not actively involved in decisions about whether ill food workers should work. Additionally, almost 70% of managers said they had worked while ill; 10% said they had worked while having nausea or "stomach flu," possible symptoms of foodborne illness. When asked why they had worked when ill, a third of the managers said they felt obligated to work or their strong work ethic compelled them to work. Other reasons cited were that the restaurant was understaffed or no one was available to replace them (26%), they felt that their symptoms were mild or not contagious (19%), they had special managerial responsibilities that no one else could fulfill (11%), there was non food handling work they could do (7%), and they would not get paid if they did not work or the restaurant had no sick leave policy (5%). Data from this study can inform future research and help policy makers target interventions designed to reduce the frequency with Which food workers work while ill. C1 [Norton, D. M.] Calif Emerging Infect Program, Oakland, CA 94612 USA. [Brown, L. G.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. [Frick, R.] Calif Dept Publ Hlth, Food & Drug Branch, Richmond, CA 94808 USA. [Carpenter, L. R.; Green, A. L.] Tennessee Dept Hlth, Nashville, TN 37243 USA. [Tobin-D'Angelo, M.] Georgia Dept Publ Hlth, Atlanta, GA 30303 USA. [Reimann, D. W.; Everstine, K.] Minnesota Dept Hlth, St Paul, MN 55164 USA. [Blade, H.] Rhode Isl Dept Hlth, Providence, RI 02908 USA. [Nicholas, D. C.; Egan, J. S.] New York State Dept Hlth, Albany, NY 12237 USA. RP Brown, LG (reprint author), Sonomaceut WholeVine Prod, 421 Aviat Blvd, Santa Rosa, CA 95402 USA. EM lrg0@cdc.gov FU Centers for Disease Control and Prevention [CDC-RFA-EH05-013] FX This study was conducted in sites receiving Centers for Disease Control and Prevention cooperative agreement awards funded under CDC-RFA-EH05-013. This publication is based on data collected and provided by the CDC's Environmental Health Specialists Network. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the CDC nor the Agency for Toxic Substances and Disease Registry. NR 9 TC 3 Z9 3 U1 0 U2 2 PU INT ASSOC FOOD PROTECTION PI DES MOINES PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2863 USA SN 0362-028X EI 1944-9097 J9 J FOOD PROTECT JI J. Food Prot. PD JAN PY 2015 VL 78 IS 1 BP 187 EP 195 DI 10.4315/0362-028X.JFP-14-134 PG 9 WC Biotechnology & Applied Microbiology; Food Science & Technology SC Biotechnology & Applied Microbiology; Food Science & Technology GA AZ1QB UT WOS:000348012000025 PM 25581195 ER PT J AU Heitbrink, WA Lo, LM Dunn, KH AF Heitbrink, William A. Lo, Li-Ming Dunn, Kevin H. TI Exposure Controls for Nanomaterials at Three Manufacturing Sites SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE airborne contaminants; control evaluation; engineering controls; engineered nanomaterials; hazard prevention ID REACTOR CLEANOUT OPERATIONS; EXHAUST VENTILATION LEV; ENGINEERED NANOMATERIALS; ULTRAFINE PARTICLES; AIRBORNE PARTICLES; CARBON NANOFIBERS; RISK-MANAGEMENT; NANOPARTICLES; WORKPLACES; IDENTIFICATION AB Because nanomaterials are thought to be more biologically active than their larger parent compounds, careful control of exposures to nanomaterials is recommended. Field studies were conducted at three sites to develop information about the effectiveness of control measures including process changes, a downflow room, a ventilated enclosure, and an enclosed reactor. Aerosol mass and number concentrations were measured during specific operations with a photometer and an electrical mobility particle sizer to provide concentration measurements across a broad range of sizes (from 5.6 nm to 30 mu m). At site A, the dust exposure and during product harvesting was eliminated by implementing a wait time of 30 -min following process completion. And, the dust exposure attributed to process tank cleaning was reduced from 0.7 to 0.2 mg/m(3) by operating the available process ventilation during this task. At site B, a ventilated enclosure was used to control dust generated by the manual weigh-out and manipulation of powdered nanomaterials inside of a downflow room. Dust exposures were at room background (under 0.04 mg/m(3) and 500 particles/cm(3)) during these tasks however, manipulations conducted outside of the enclosure were correlated with a transient increase in concentration measured at the source. At site C, a digitally controlled reactor was used to produce aligned carbon nanotubes. This reactor was a closed system and the ventilation functioned as a redundant control measure. Process emissions were well controlled by this system with the exception of increased concentrations measured during the unloading of the product. However, this emission source could be easily controlled through increasing cabinet ventilation. The identification and adoption of effective control technologies is an important first step in reducing the risk associated with worker exposure to engineered nanoparticles. Properly designing and evaluating the effectiveness of these controls is a key component in a comprehensive health and safety program. C1 [Heitbrink, William A.] LMK OSH Consulting LLC, Cincinnati, OH USA. [Lo, Li-Ming; Dunn, Kevin H.] NIOSH, Div Appl Res & Technol, Ctr Dis Control & Prevent CDC, Cincinnati, OH 45226 USA. RP Lo, LM (reprint author), 1090 Tusculum Ave,MS-R5, Cincinnati, OH 45226 USA. EM LLo@cdc.gov FU National Institute for Occupational Safety and Health under the Nanotechnology Research Center [927ZJLR] FX This research was funded by the National Institute for Occupational Safety and Health under the Nanotechnology Research Center project 927ZJLR. NR 46 TC 7 Z9 7 U1 3 U2 22 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD JAN PY 2015 VL 12 IS 1 BP 16 EP 28 DI 10.1080/15459624.2014.930559 PG 13 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AZ1ZJ UT WOS:000348033600003 PM 24918905 ER PT J AU Smith, JP Sammons, DL Robertson, SA Snawder, JE AF Smith, Jerome P. Sammons, Deborah L. Robertson, Shirley A. Snawder, John E. TI Enhanced Performance of Methamphetamine Lateral Flow Cassettes Using an Electronic Lateral Flow Reader SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE direct reading; lateral flow; methamphetamine AB Surface contamination from methamphetamine in meth labs continues to be a problem. We had previously developed a lateral flow assay cassette for field detection of methamphetamine contamination that is commercially available and has been used by a number of groups to assess contamination. This cassette uses the complete disappearance of the test line as an end point for detection of 50 ng/100 cm(2) of methamphetamine contamination for surface sampling with cotton swabs. In the present study, we further evaluate the response of the cassettes using an electronic lateral flow reader to measure the intensities of the test and control lines. The cassettes were capable of detecting 0.25 ng/ml for calibration solutions. For 100 cm(2) ceramic tiles that were spiked with methamphetamine and wiped with cotton-tipped wooden swabs wetted in assay/sampling buffer, 1 ng/tile was detected using the reader. Semi-quantitative results can be produced over the range 0-10 ng/ml for calibration solutions and 0-25 ng/tile for spiked tiles using either a 4-parameter logistic fit of test line intensity versus concentration or spiked mass or the ratio of the control line to the test line intensity fit to concentration or spiked mass. Recovery from the tiles was determined to be about 30% using the fitted curves. Comparison of the control line to the test line was also examined as a possible visual detection end point and it was found that the control line became more intense than the test line at 0.5 to 1 ng/ml for calibration solutions or 1 to 2 ng/tile for spiked tiles. Thus the lateral flow cassettes for methamphetamine have the potential to produce more sensitive semi-quantitative results if an electronic lateral flow reader is used and can be more sensitive for detection if the comparison of the control line to the test line is used as the visual end point. C1 [Smith, Jerome P.; Sammons, Deborah L.; Robertson, Shirley A.; Snawder, John E.] NIOSH, Div Appl Res & Technol, US Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. RP Smith, JP (reprint author), NIOSH, Div Appl Res & Technol, US Ctr Dis Control & Prevent, 4676 Columbia Pkwy, Cincinnati, OH 45226 USA. EM jps3@cdc.gov FU Intramural CDC HHS [CC999999] NR 10 TC 1 Z9 1 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD JAN PY 2015 VL 12 IS 1 BP 45 EP 50 DI 10.1080/15459624.2014.935782 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AZ1ZJ UT WOS:000348033600006 PM 25379615 ER PT J AU Schubauer-Berigan, MK Dahm, MM Schulte, PA Hodson, L Geraci, CL AF Schubauer-Berigan, Mary K. Dahm, Matthew M. Schulte, Paul A. Hodson, Laura Geraci, Charles L. TI Characterizing Adoption of Precautionary Risk Management Guidance for Nanomaterials, an Emerging Occupational Hazard SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article DE engineering controls; exposure; health; hierarchy of controls; nanotechnology; personal protective equipment (PPE) AB Exposure to engineered nanomaterials (substances with at least one dimension of 1-100 nm) has been of increased interest, with the recent growth in production and use of nanomaterials worldwide. Various organizations have recommended methods to minimize exposure to engineered nanomaterials. The purpose of this study was to evaluate available data to examine the extent to which studied U.S. companies (which represent a small fraction of all companies using certain forms of engineered nanomaterials) follow the guidelines for reducing occupational exposures to engineered nanomaterials that have been issued by the National Institute for Occupational Safety and Health (NIOSH) and other organizations. Survey data, field reports, and field notes for all NIOSH nanomaterial exposure assessments conducted between 2006 and 2011 were collected and reviewed to: (1) determine the level of adoption of precautionary guidance on engineering controls and personal protective equipment (PPE), and (2) evaluate the reliability of companies' self-reported use of engineering controls and PPE. Use of PPE was observed among 89% [95% confidence interval (CI): 76%-96%] of 46 visited companies, and use of containment-based engineering controls for at least some processes was observed among 83% (95% CI: 76%-96%). In on-site evaluations, more than 90% of the 16 engineered carbonaceous nanomaterial companies that responded to an industry wide survey were observed to be using engineering controls and PPE as reported or more stringently than reported. Since PPE use was slightly more prevalent than engineering controls, better communication may be necessary to reinforce the importance of the hierarchy of controls. These findings may also be useful in conducting exposure assessment and epidemiologic research among U.S. workers handling nanomaterials. C1 [Schubauer-Berigan, Mary K.; Dahm, Matthew M.] NIOSH, Div Surveillance Hazard Evaluat & Field Studies, Cincinnati, OH 45226 USA. [Schulte, Paul A.; Hodson, Laura; Geraci, Charles L.] NIOSH, Educ & Informat Div, Cincinnati, OH 45226 USA. RP Schubauer-Berigan, MK (reprint author), NIOSH, Div Surveillance Hazard Evaluat & Field Studies, 1090 Tusculum Ave, Cincinnati, OH 45226 USA. EM zcg3@cdc.gov FU NIOSH Nanotechnology Research Center; National Institute of Environmental Health Sciences [AES12029-001-00000, AES12011-001-00001, Y1ES-9026-04] FX This study was funded by the NIOSH Nanotechnology Research Center and by the National Institute of Environmental Health Sciences (Interagency Agreement numbers AES12029-001-00000, AES12011-001-00001, and Y1ES-9026-04). NR 15 TC 2 Z9 2 U1 3 U2 17 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD JAN PY 2015 VL 12 IS 1 BP 69 EP 75 DI 10.1080/15459624.2014.946515 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AZ1ZJ UT WOS:000348033600009 PM 25093252 ER PT J AU Boylan, B Rice, AS Dunn, AL Tarantino, MD Brettler, DB Barrett, JC Miller, CH AF Boylan, B. Rice, A. S. Dunn, A. L. Tarantino, M. D. Brettler, D. B. Barrett, J. C. Miller, C. H. CA Hemophilia Inhibitor Res Study TI Characterization of the anti-factor VIII immunoglobulin profile in patients with hemophilia A by use of a fluorescence-based immunoassay SO JOURNAL OF THROMBOSIS AND HAEMOSTASIS LA English DT Article DE factorVIII; factorVIII deficiency; hemophiliaA; immunoassay; inherited blood coagulation disorders ID IMMUNE TOLERANCE INDUCTION; INHIBITOR DEVELOPMENT; BETHESDA ASSAY; EPITOPE SPECIFICITY; UNITED-STATES; CLASS-II; ANTIBODIES; POLYMORPHISMS; COHORT; GENES AB BackgroundThe development of neutralizing antibodies, referred to as inhibitors, against factorVIII is a major complication associated with FVIII infusion therapy for the treatment of hemophiliaA (HA). Previous studies have shown that a subset of HA patients and a low percentage of healthy individuals harbor non-neutralizing anti-FVIII antibodies that do not elicit the clinical manifestations associated with inhibitor development. ObjectiveTo assess HA patients' anti-FVIII antibody profiles as potential predictors of clinical outcomes. MethodsA fluorescence immunoassay (FLI) was used to detect anti-FVIII antibodies in 491 samples from 371 HA patients. ResultsAssessments of antibody profiles showed that the presence of anti-FVIII IgG(1), IgG(2) or IgG(4) correlated qualitatively and quantitatively with the presence of an FVIII inhibitor as determined with the Nijmegen-Bethesda assay (NBA). Forty-eight patients with a negative inhibitor history contributed serial samples to the study, including seven patients who had negative NBA titers initially and later converted to being NBA-positive. The FLI detected anti-FVIII IgG(1) in five of those seven patients prior to their conversion to NBA-positive. Five of 15 serial-sample patients who had a negative inhibitor history and had anti-FVIII IgG(1) later developed an inhibitor, as compared with two of 33 patients with a negative inhibitor history without anti-FVIII IgG(1). ConclusionsThese data provide a rationale for future studies designed both to monitor the dynamics of anti-FVIII antibody profiles in HA patients as a potential predictor of future inhibitor development and to assess the value of the anti-FVIII FLI as a supplement to traditional inhibitor testing. C1 [Boylan, B.; Rice, A. S.; Miller, C. H.] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Dunn, A. L.] Emory Univ, Atlanta, GA 30322 USA. [Tarantino, M. D.] Bleeding & Clotting Disorders Inst, Peoria, IL USA. [Brettler, D. B.] New England Hemophilia Ctr, Worcester, MA USA. [Barrett, J. C.] Virginia Commonwealth Univ, Richmond, VA USA. RP Boylan, B (reprint author), Natl Ctr Birth Defects & Dev Disabil, Div Blood Disorders, 1600 Clifton Rd,MS D-02, Atlanta, GA 30333 USA. EM bboylan@cdc.gov OI Miller, Connie H/0000-0002-3989-7973 FU CDC Foundation through a grant from Pfizer Pharmaceuticals; Bayer Healthcare; Biogen-Idec; CSL Behring; Pfizer; NHLBI; Children's Healthcare of Atlanta; CDC Foundation; Pfizer Pharmaceuticals; ATHN; CDC; HRSA; Kedrion; Novo Nordisk; Amgen; Baxter; Bayer; BPL; Cangene; Grifols FX This work was supported by the CDC Foundation through a grant from Pfizer Pharmaceuticals. The findings and conclusions in this report are those of the authors, and do not necessarily represent the views of the Centers for Disease Control and Prevention. A. L. Dunn reports receiving personal fees from Bayer Healthcare, Biogen-Idec, CSL Behring, and Pfizer, and grants from NHLBI and Children's Healthcare of Atlanta, outside the submitted work. C. H. Miller reports receiving grants from the CDC Foundation and Pfizer Pharmaceuticals during the conduct of the study. M. D. Tarantino reports receiving grants from ATHN, CDC, and HRSA, and other support from Kedrion, Novo Nordisk, Pfizer, Amgen, Baxter, Bayer, BPL, Cangene, and Grifols, outside the submitted work. The other authors state that they have no conflict of interest. NR 30 TC 5 Z9 5 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1538-7933 EI 1538-7836 J9 J THROMB HAEMOST JI J. Thromb. Haemost. PD JAN PY 2015 VL 13 IS 1 BP 47 EP 53 DI 10.1111/jth.12768 PG 7 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA AZ0ZS UT WOS:000347970900008 PM 25354263 ER PT J AU Lederer, P Briggs, M Hassani, AS Date, A AF Lederer, Philip Briggs, Melissa Hassani, Ahmed Saadani Date, Anand TI TB-HAART trial SO LANCET INFECTIOUS DISEASES LA English DT Letter ID ANTIRETROVIRAL THERAPY C1 [Lederer, Philip; Briggs, Melissa; Hassani, Ahmed Saadani; Date, Anand] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA 30333 USA. RP Lederer, P (reprint author), Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA 30333 USA. EM lederer@gmail.com NR 4 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD JAN PY 2015 VL 15 IS 1 BP 14 EP 14 PG 1 WC Infectious Diseases SC Infectious Diseases GA AY9GD UT WOS:000347857900011 PM 25541162 ER PT J AU Karagiannis-Voules, DA Biedermann, P Ekpo, UF Garba, A Langer, E Mathieu, E Midzi, N Mwinzi, P Polderman, AM Raso, G Sacko, M Talla, I Tchuente, LAT Toure, S Winkler, MS Utzinger, J Vounatsou, P AF Karagiannis-Voules, Dimitrios-Alexios Biedermann, Patricia Ekpo, Uwem F. Garba, Amadou Langer, Erika Mathieu, Els Midzi, Nicholas Mwinzi, Pauline Polderman, Anton M. Raso, Giovanna Sacko, Moussa Talla, Idrissa Tchuente, Louis-Albert Tchuem Toure, Seydou Winkler, Mirko S. Utzinger, Jurg Vounatsou, Penelope TI Spatial and temporal distribution of soil-transmitted helminth infection in sub-Saharan Africa: a systematic review and geostatistical meta-analysis SO LANCET INFECTIOUS DISEASES LA English DT Article ID NEGLECTED TROPICAL DISEASES; TRICHURIS-TRICHIURA; GLOBAL BURDEN; HEALTH-POLICY; COTE-DIVOIRE; SCHISTOSOMIASIS; PREDICTION; SCHOOLCHILDREN; PREVALENCE; IVERMECTIN AB Background Interest is growing in predictive risk mapping for neglected tropical diseases (NTDs), particularly to scale up preventive chemotherapy, surveillance, and elimination efforts. Soil-transmitted helminths (hookworm, Ascaris lumbricoides, and Trichuris trichiura) are the most widespread NTDs, but broad geographical analyses are scarce. We aimed to predict the spatial and temporal distribution of soil-transmitted helminth infections, including the number of infected people and treatment needs, across sub-Saharan Africa. Methods We systematically searched PubMed, Web of Knowledge, and African journal Online from inception to Dec 31, 2013, without language restrictions, to identify georeferenced surveys. We extracted data from household surveys on sources of drinking water, sanitation, and women's level of education. Bayesian geostatistical models were used to align the data in space and estimate risk of with hookworm, A lumbricoides, and T trichiura over a grid of roughly 1 million pixels at a spatial resolution of 5 x 5 km. We calculated anthelmintic treatment needs on the basis of WHO guidelines (treatment of all school-aged children once per year where prevalence in this population is 20-50% or twice per year if prevalence is greater than 50%). Findings We identified 459 relevant survey reports that referenced 6040 unique locations. We estimate that the prevalence of hookworm, A lutnbricoides, and T trichiura among school-aged children from 2000 onwards was 16.5%, 6.6%, and 4.4%. These estimates are between 52% and 74% lower than those in surveys done before 2000, and have become similar to values for the entire communities. We estimated that 126 million doses of anthelmintic treatments are required per year. Interpretation Patterns of soil-transmitted helminth infection in sub-Saharan Africa have changed and the prevalence of infection has declined substantially in this millennium, probably due to socioeconomic development and large-scale deworming programmes. The global control strategy should be reassessed, with emphasis given also to adults to progress towards local elimination. C1 [Karagiannis-Voules, Dimitrios-Alexios; Biedermann, Patricia; Langer, Erika; Raso, Giovanna; Winkler, Mirko S.; Utzinger, Jurg; Vounatsou, Penelope] Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, CH-4002 Basel, Switzerland. [Karagiannis-Voules, Dimitrios-Alexios; Biedermann, Patricia; Langer, Erika; Raso, Giovanna; Winkler, Mirko S.; Utzinger, Jurg; Vounatsou, Penelope] Univ Basel, Basel, Switzerland. [Ekpo, Uwem F.] Fed Univ Agr, Dept Biol Sci, Abeokuta, Nigeria. [Garba, Amadou] Reseau Int Schistosomiases Environm Amenagements, Niamey, Niger. [Mathieu, Els] Ctr Dis Control & Prevent, Ctr Global Hlth, Atlanta, GA USA. [Midzi, Nicholas] Univ Zimbabwe, Coll Hlth Sci, Dept Med Microbiol, Harare, Zimbabwe. [Mwinzi, Pauline] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Polderman, Anton M.] Leiden Univ, Med Ctr, Dept Parasitol, Leiden, Netherlands. [Sacko, Moussa] Inst Natl Rech Sante Publ, Bamako, Mali. [Talla, Idrissa] Minist Sante, Direct Lutte Malad, Dakar, Senegal. [Tchuente, Louis-Albert Tchuem] Univ Yaounde I, Lab Parasitol & Ecol, Yaounde, Cameroon. [Tchuente, Louis-Albert Tchuem] Ctr Schistosomiasis & Parasitol, Yaounde, Cameroon. [Toure, Seydou] Minist Sante, Programme Natl Lutte Schistosomiase, Ouagadougou, Burkina Faso. RP Vounatsou, P (reprint author), Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Socinstr 57, CH-4002 Basel, Switzerland. EM penelope.vounatsou@unibas.ch OI Ekpo, Uwemedimo/0000-0002-0543-5463 FU Swiss National Science Foundation; European Research Council FX Funding Swiss National Science Foundation and European Research Council. NR 64 TC 32 Z9 32 U1 11 U2 24 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD JAN PY 2015 VL 15 IS 1 BP 74 EP 84 DI 10.1016/S1473-3099(14)71004-7 PG 11 WC Infectious Diseases SC Infectious Diseases GA AY9GD UT WOS:000347857900030 PM 25486852 ER PT J AU Checkley, W White, AC Jaganath, D Arrowood, MJ Chalmers, RM Chen, XM Fayer, R Griffiths, JK Guerrant, RL Hedstrom, L Huston, CD Kotloff, KL Kang, G Mead, JR Miller, M Petri, WA Priest, JW Roos, DS Striepen, B Thompson, RCA Ward, HD Van Voorhis, WA Xiao, LH Zhu, G Houpt, ER AF Checkley, William White, A. Clinton, Jr. Jaganath, Devon Arrowood, Michael J. Chalmers, Rachel M. Chen, Xian-Ming Fayer, Ronald Griffiths, Jeffrey K. Guerrant, Richard L. Hedstrom, Lizbeth Huston, Christopher D. Kotloff, Karen L. Kang, Gagandeep Mead, Jan R. Miller, Mark Petri, William A., Jr. Priest, Jeffrey W. Roos, David S. Striepen, Boris Thompson, R. C. Andrew Ward, Honorine D. Van Voorhis, Wesley A. Xiao, Lihua Zhu, Guan Houpt, Eric R. TI A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium SO LANCET INFECTIOUS DISEASES LA English DT Review ID INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; SYSTEMIC ANTIBODY-RESPONSES; INTESTINAL EPITHELIAL-CELLS; RANDOMIZED CONTROLLED-TRIAL; EARLY-CHILDHOOD DIARRHEA; MANNOSE-BINDING LECTIN; NATURAL-KILLER-CELLS; TIME PCR DETECTION; PARVUM INFECTION AB Cryptosporidium spp are well recognised as causes of diarrhoeal disease during waterborne epidemics and in immunocompromised hosts. Studies have also drawn attention to an underestimated global burden and suggest major gaps in optimum diagnosis, treatment, and immunisation. Cryptosporidiosis is increasingly identified as an important cause of morbidity and mortality worldwide. Studies in low-resource settings and high-income countries have confirmed the importance of cryptosporidium as a cause of diarrhoea and childhood malnutrition. Diagnostic tests for cryptosporidium infection are suboptimum, necessitating specialised tests that are often insensitive. Antigen-detection and PCR improve sensitivity, and multiplexed antigen detection and molecular assays are underused. Therapy has some effect in healthy hosts and no proven efficacy in patients with AIDS. Use of cryptosporidium genomes has helped to identify promising therapeutic targets, and drugs are in development, but methods to assess the efficacy in vitro and in animals are not well standardised. Partial immunity after exposure suggests the potential for successful vaccines, and several are in development; however, surrogates of protection are not well defined. Improved methods for propagation and genetic manipulation of the organism would be significant advances. C1 [Checkley, William; Jaganath, Devon] Johns Hopkins Univ, Dept Int Hlth, Program Global Dis Epidemiol & Control, Baltimore, MD USA. [Checkley, William; Miller, Mark] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [White, A. Clinton, Jr.] Univ Texas Med Branch, Div Infect Dis, Galveston, TX 77555 USA. [Arrowood, Michael J.; Priest, Jeffrey W.; Xiao, Lihua] Ctr Dis Control & Prevent, Atlanta, GA USA. [Chalmers, Rachel M.] Publ Hlth Wales, Natl Cryptosporidium Reference Unit, Swansea, W Glam, Wales. [Chen, Xian-Ming] Creighton Univ, Dept Med Microbiol & Immunol, Omaha, NE 68178 USA. [Fayer, Ronald] USDA, Environm Microbial Food Safety Lab, Beltsville, MD 20705 USA. [Griffiths, Jeffrey K.] Tufts Univ, Dept Publ Hlth & Community Med, Boston, MA 02111 USA. [Guerrant, Richard L.; Petri, William A., Jr.; Houpt, Eric R.] Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA USA. [Hedstrom, Lizbeth] Brandeis Univ, Dept Biol, Waltham, MA 02254 USA. [Hedstrom, Lizbeth] Brandeis Univ, Dept Chem, Waltham, MA 02254 USA. [Huston, Christopher D.] Univ Vermont, Div Infect Dis, Burlington, VT USA. [Kotloff, Karen L.] Univ Maryland, Sch Med, Div Infect Dis & Trop Pediat, Dept Pediat,Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Kang, Gagandeep] Christian Med Coll & Hosp, Div Gastrointestinal Sci, Vellore, Tamil Nadu, India. [Mead, Jan R.] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA. [Mead, Jan R.] Atlanta VA Med Ctr, Decatur, GA USA. [Roos, David S.] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA. [Striepen, Boris] Univ Georgia, Ctr Trop & Emerging Global Dis, Athens, GA 30602 USA. [Thompson, R. C. Andrew] Murdoch Univ, Sch Vet & Life Sci, Perth, WA, Australia. [Ward, Honorine D.] Tufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA USA. [Van Voorhis, Wesley A.] Univ Washington, Dept Med, Allergy & Infect Dis Div, Seattle, WA USA. [Van Voorhis, Wesley A.] Univ Washington, Allergy & Infect Dis Div, Dept Global Hlth, Seattle, WA 98195 USA. [Van Voorhis, Wesley A.] Univ Washington, Dept Microbiol, Allergy & Infect Dis Div, Seattle, WA 98195 USA. [Zhu, Guan] Texas A&M Univ, Dept Vet Pathobiol, College Stn, TX USA. RP Checkley, W (reprint author), Johns Hopkins Univ, Sch Med, Suite 9121,1800 Orleans Ave, Baltimore, MD 21205 USA. EM wcheckl1@jhmi.edu RI Xiao, Lihua/B-1704-2013; OI Xiao, Lihua/0000-0001-8532-2727; White, A Clinton/0000-0002-9668-4632; Striepen, Boris/0000-0002-7426-432X FU Bill & Melinda Gates Foundation FX We acknowledge all speakers who attended the meeting Cryptosporidium: Global Burden, Novel Diagnostics, Therapeutics and Vaccine Targets, held in Philadelphia, PA, USA, in December, 2011. We received financial support from the Bill & Melinda Gates Foundation; our funding source did not have a role in the development of this Review. The findings and conclusions in this Review are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 148 TC 72 Z9 74 U1 15 U2 64 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1473-3099 EI 1474-4457 J9 LANCET INFECT DIS JI Lancet Infect. Dis. PD JAN PY 2015 VL 15 IS 1 BP 85 EP 94 DI 10.1016/S1473-3099(14)70772-8 PG 10 WC Infectious Diseases SC Infectious Diseases GA AY9GD UT WOS:000347857900031 PM 25278220 ER PT J AU Looker, AC AF Looker, A. C. TI Dysmobility syndrome and mortality risk in US men and women age 50 years and older SO OSTEOPOROSIS INTERNATIONAL LA English DT Article DE Dysmobility; Longitudinal study; Mortality; NHANES ID BODY-MASS INDEX; MUSCLE STRENGTH; SARCOPENIA; OSTEOPOROSIS; SIMULATION; DIAGNOSIS; DISEASE AB Mortality risk was significantly elevated in older adults from NHANES 1999-2002 with dysmobility syndrome. Dysmobility syndrome was recently proposed as an approach to evaluate the musculoskeletal health of older persons, but data linking this syndrome to adverse outcomes are currently lacking. The present study used data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002 to assess the relationship between dysmobility and mortality in adults age 50 years and older by age, sex, and race or ethnicity. Dysmobility was defined as three or more of the following: high body fat, osteoporosis, low muscle mass, low muscle strength, slow gait speed, or falling risk. Body composition and bone density were assessed with dual energy X-ray absorptiometry. Gait speed was measured via a timed walk, muscle strength via isokinetic knee extension, and fall risk via self-reported balance problems in the past year. Hazard ratios (HRs) for mortality were calculated with Cox proportional hazard models. Twenty-two percent of adults age 50+ years had dysmobility in 1999-2002. Mortality risk by dysmobility varied significantly by age (p (interaction) = 0.001). HRs for those aged 50-69 years were 3.63 (95 % confidence interval (CI) 2.69, 4.90) and 2.59 (95 % CI 1.82, 3.69), respectively, before and after adjusting for all confounders, compared with 1.46 (95 % CI 1.07, 1.99) and 1.23 (95 % CI 0.89, 1.69) for those aged 70+ years. The relationship was significant when examined by sex or race/ethnicity within age group for most subgroups. Dysmobility was associated with increased mortality risk in adults age 50 years and older, with risk being higher in those age 50-69 years than in those age 70+ years. C1 Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD USA. RP Looker, AC (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Room 4310,3311 Toledo Rd, Hyattsville, MD USA. EM ALooker@cdc.gov FU Intramural CDC HHS [CC999999] NR 24 TC 3 Z9 3 U1 1 U2 1 PU SPRINGER LONDON LTD PI LONDON PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND SN 0937-941X EI 1433-2965 J9 OSTEOPOROSIS INT JI Osteoporosis Int. PD JAN PY 2015 VL 26 IS 1 BP 93 EP 102 DI 10.1007/s00198-014-2904-1 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AY6PZ UT WOS:000347689400010 PM 25297891 ER PT J AU Brown, DS Thompson, WW Zack, MM Arnold, SE Barile, JP AF Brown, Derek S. Thompson, William W. Zack, Matthew M. Arnold, Sarah E. Barile, John P. TI Associations Between Health-Related Quality of Life and Mortality in Older Adults SO PREVENTION SCIENCE LA English DT Article DE Mortality; Survival analysis; Quality of life; Medicare ID MEDICARE MANAGED CARE; SELF-RATED HEALTH; PROGNOSTIC-FACTORS; SURVIVAL; PREDICTOR; PEOPLE; US; DISENROLLMENT; POPULATION; DISABILITY AB This study measures the use and relative importance of different measures of health-related quality of life (HRQOL) as predictors of mortality in a large sample of older US adults. We used Cox proportional hazards models to analyze the association between general self-reported health and three "healthy days" (HDs) measures of HRQOL and mortality at short-term (90-day) and long-term (2.5 years) follow-up. The data were from Cohorts 6 through 8 of the Medicare Health Outcomes Survey, a national sample of older adults who completed baseline surveys in 2003-2005. At the long term, reduced HRQOL in general health and all categories of the HDs were separately and significantly associated with greater mortality (P < 0.001). In multivariate analysis of long-term mortality, at least one HD category remained significant for each measure, but the associations between mental health and mortality were inconsistent. For short-term mortality, the physical health measures had larger hazard ratios, but fewer categories were significant. Hazard ratios decreased over time for all measures of HRQOL except mental health. In conclusion, HRQOL measures were shown to be significant predictors of short- and long-term mortality, further supporting their value in health surveillance and as markers of risk for targeted prevention efforts. Although all four measures of HRQOL significantly predicted mortality, general self-rated health and age were more important predictors than the HDs. C1 [Brown, Derek S.] Washington Univ, Brown Sch, St Louis, MO 63130 USA. [Thompson, William W.; Zack, Matthew M.] Ctr Dis Control & Prevent, Div Behav Surveillance, Publ Hlth Surveillance Program Off, Atlanta, GA USA. [Arnold, Sarah E.] RTI Int, Publ Hlth Econ Program, Res Triangle Pk, NC USA. [Barile, John P.] Univ Hawaii Manoa, Dept Psychol, Honolulu, HI 96822 USA. RP Brown, DS (reprint author), Washington Univ, Brown Sch, One Brookings Dr,Campus Box 1196, St Louis, MO 63130 USA. EM dbrown@brownschool.wustl.edu RI Barile, John/F-9456-2015; Brown, Derek/J-3035-2013 OI Barile, John/0000-0003-4098-0640; Brown, Derek/0000-0001-9908-9882 FU Intramural CDC HHS [CC999999] NR 37 TC 8 Z9 9 U1 0 U2 5 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1389-4986 EI 1573-6695 J9 PREV SCI JI Prev. Sci. PD JAN PY 2015 VL 16 IS 1 BP 21 EP 30 DI 10.1007/s11121-013-0437-z PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY4EZ UT WOS:000347532300003 PM 24189743 ER PT J AU Carlson, SA Fulton, JE Pratt, M Yang, Z Adams, EK AF Carlson, Susan A. Fulton, Janet E. Pratt, Michael Yang, Zhou Adams, E. Kathleen TI Inadequate Physical Activity and Health Care Expenditures in the United States SO PROGRESS IN CARDIOVASCULAR DISEASES LA English DT Review DE Physical activity; Exercise; Health expenditures; Health care ID BODY-MASS-INDEX; ECONOMIC COSTS; PANEL SURVEY; MEDICARE EXPENDITURES; INACTIVITY; OBESITY; CANADA; BURDEN; UPDATE; MODELS AB This study estimates the percentage of health care expenditures in the non-institutionalized United States (U.S.) adult population associated with levels of physical activity inadequate to meet current guidelines. Leisure-time physical activity data from the National Health Interview Survey (2004-2010) were merged with health care expenditure data from the Medical Expenditure Panel Survey (2006-2011). Health care expenditures for inactive (i.e., no physical activity) and insufficiently active adults (i.e., some physical activity but not enough to meet guidelines) were compared with active adults (i.e., >= 150 minutes/week moderate-intensity equivalent activity) using an econometric model. Overall, 11.1% (95% CI: 7.3, 14.9) of aggregate health care expenditures were associated with inadequate physical activity (i.e., inactive and insufficiently active levels). When adults with any reported difficulty walking due to a health problem were excluded, 8.7% (95% CI: 5.2, 12.3) of aggregate health care expenditures were associated with inadequate physical activity. Increasing adults' physical activity to meet guidelines may reduce U.S. health care expenditures. Published by Elsevier Inc. C1 [Carlson, Susan A.; Fulton, Janet E.; Pratt, Michael] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Carlson, Susan A.; Yang, Zhou; Adams, E. Kathleen] Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA. [Pratt, Michael] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. RP Carlson, SA (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, 4770 Buford Hwy NE,MS F-77, Atlanta, GA 30341 USA. EM scarlson1@cdc.gov FU Intramural CDC HHS [CC999999] NR 34 TC 46 Z9 46 U1 4 U2 20 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0033-0620 EI 1873-1740 J9 PROG CARDIOVASC DIS JI Prog. Cardiovasc. Dis. PD JAN-FEB PY 2015 VL 57 IS 4 BP 315 EP 323 DI 10.1016/j.pcad.2014.08.002 PG 9 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AZ1MU UT WOS:000348003900005 PM 25559060 ER PT J AU Beyer, KMM Layde, PM Hamberger, LK Laud, PW AF Beyer, Kirsten M. M. Layde, Peter M. Hamberger, L. Kevin Laud, Purushottam W. TI Does Neighborhood Environment Differentiate Intimate Partner Femicides From Other Femicides? SO VIOLENCE AGAINST WOMEN LA English DT Article DE intimate partner femicide; neighborhoods; residence characteristics ID SOCIAL-DISORGANIZATION THEORY; MULTILEVEL ANALYSIS; DOMESTIC VIOLENCE; WOMEN; PREVALENCE; MATTER; DISADVANTAGE; HOUSEHOLD; HOMICIDE; CONTEXT AB We examined the association between neighborhood-level factors and intimate partner femicide (IPF) using Wisconsin Violent Death Reporting System (WVDRS) data and Wisconsin Coalition Against Domestic Violence (WCADV) reports, in concert with neighborhood-level information. After controlling for individual characteristics, neighborhood-level disadvantage was associated with a decreased likelihood of IPF status, as compared with other femicides, whereas neighborhood-level residential instability was associated with an increased likelihood of IPF status. Neighborhood plays a role in differentiating IPFs from other femicides in our study area. Our findings demonstrate the importance of multilevel strategies for understanding and reducing the burden of intimate partner violence. C1 [Beyer, Kirsten M. M.] Med Coll Wisconsin, Inst Hlth & Soc, Milwaukee, WI 53226 USA. [Layde, Peter M.] Med Coll Wisconsin, Dept Emergency Med, Milwaukee, WI 53226 USA. [Layde, Peter M.] Med Coll Wisconsin, US Ctr Dis Control & Prevent CDC, Injury Res Ctr, Milwaukee, WI 53226 USA. [Hamberger, L. Kevin] Med Coll Wisconsin, Dept Family & Community Med, Milwaukee, WI 53226 USA. [Laud, Purushottam W.] Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA. RP Beyer, KMM (reprint author), Med Coll Wisconsin, Inst Hlth & Soc, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA. EM kbeyer@mcw.edu FU NCATS NIH HHS [UL1 TR000055]; NCIPC CDC HHS [R49 CE001175, R49/CE001175]; NCRR NIH HHS [UL1 RR031973, UL1RR031973]; PHS HHS [T32-HP10030, U17/CCU523099] NR 27 TC 2 Z9 2 U1 2 U2 8 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1077-8012 EI 1552-8448 J9 VIOLENCE AGAINST WOM JI Violence Against Women PD JAN PY 2015 VL 21 IS 1 BP 49 EP 64 DI 10.1177/1077801214564075 PG 16 WC Women's Studies SC Women's Studies GA AZ0RH UT WOS:000347951800003 PM 25540251 ER PT J AU Pauvolid-Correa, A Solberg, O Couto-Lima, D Kenney, J Serra-Freire, N Brault, A Nogueira, R Langevin, S Komar, N AF Pauvolid-Correa, Alex Solberg, Owen Couto-Lima, Dinair Kenney, Joan Serra-Freire, Nicolau Brault, Aaron Nogueira, Rita Langevin, Stanley Komar, Nicholas TI Nhumirim virus, a novel flavivirus isolated from mosquitoes from the Pantanal, Brazil SO ARCHIVES OF VIROLOGY LA English DT Article ID WEST NILE VIRUS; ARBOVIRUS DISEASE; ILHEUS VIRUS; ROCIO VIRUS; CULEX; IDENTIFICATION; EMERGENCE; GENOME; TICKS AB We describe the isolation of a novel flavivirus, isolated from a pool of mosquitoes identified as Culex (Culex) chidesteri collected in 2010 in the Pantanal region of west-central Brazil. The virus is herein designated Nhumirim virus (NHUV) after the name of the ranch from which the mosquito pool was collected. Flavivirus RNA was detected by real-time RT-PCR of homogenized mosquitoes and from the corresponding C6/36 culture supernatant. Based on full-genome sequencing, the virus isolate was genetically distinct from but most closely related to Barkedji virus (BJV), a newly described flavivirus from Senegal. Phylogenetic analysis demonstrated that NHUV grouped with mosquito-borne flaviviruses forming a clade with BJV. This clade may be genetically intermediate between the Culex-borne flaviviruses amplified by birds and the insect-only flaviviruses. C1 [Couto-Lima, Dinair; Nogueira, Rita] Minist Saude, Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Flavivirus, Rio De Janeiro, RJ, Brazil. [Pauvolid-Correa, Alex; Kenney, Joan; Brault, Aaron; Komar, Nicholas] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. [Solberg, Owen; Langevin, Stanley] Sandia Natl Labs, Dept Syst Biol, Livermore, CA USA. [Serra-Freire, Nicolau] Minist Saude, Fundacao Oswaldo Cruz, Lab Referencia Nacl Vetores Riquetsioses, Rio De Janeiro, RJ, Brazil. RP Pauvolid-Correa, A (reprint author), Minist Saude, Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Flavivirus, Rio De Janeiro, RJ, Brazil. EM pauvolid@ioc.fiocruz.br FU ASM; CNPq; CAPES; Fulbright; CDC; FIOCRUZ; FAPERJ FX Special thanks to Zilca Campos from Embrapa Pantanal for her important contribution to this work. We thank Kristy Burkalther, Janae Stovall, Karen Burroughs and Robert Lanciotti from CDC, who provided laboratory assistance. We thank Thierry Tomich, Marcia Furlan, Marcos Tadeu and all staff from Embrapa Pantanal. Special thanks to Helcio Reinaldo Gil-Santana from Diptera Laboratory of FIOCRUZ, and Luiz Pellegrin of Geoprocessing Laboratory of Embrapa Pantanal. Financial support: ASM, CNPq, CAPES, Fulbright, CDC, FIOCRUZ, FAPERJ. NR 46 TC 4 Z9 4 U1 2 U2 8 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0304-8608 EI 1432-8798 J9 ARCH VIROL JI Arch. Virol. PD JAN PY 2015 VL 160 IS 1 BP 21 EP 27 DI 10.1007/s00705-014-2219-8 PG 7 WC Virology SC Virology GA AY2FE UT WOS:000347403200003 PM 25252815 ER PT J AU Fernandez, ME Savas, L Carmack, CC Chan, WY Lairson, DR Byrd, TL Wilson, KM Arvey, SR Krasny, S Vernon, SW AF Fernandez, Maria E. Savas, Lara S. Carmack, Chakema C. Chan, Wenyaw Lairson, David R. Byrd, Theresa L. Wilson, Katherine M. Arvey, Sarah R. Krasny, Sarah Vernon, Sally W. TI A randomized controlled trial of two interventions to increase colorectal cancer screening among Hispanics on the Texas-Mexico border SO CANCER CAUSES & CONTROL LA English DT Article DE Lay health workers; Colorectal cancer screening; Cancer control and prevention; Hispanics; Health disparities ID PRINT; LATINOS; BREAST; WOMEN; COLON AB Colorectal cancer (CRC) is the second and third leading cause of cancer death for Hispanic men and women, respectively. CRC can be prevented if precursors are detected early and removed and can be successfully treated if discovered early. While one-on-one interventions for increasing CRC screening (CRCS) are recommended, few studies specifically assess the effectiveness of lay health worker (LHW) approaches using different educational materials. To develop and evaluate the effectiveness of two LHW-delivered CRCS interventions known as Vale la Pena (VLP; "It's Worth It!") on increasing CRCS among Hispanics. The study design was a cluster randomized controlled trial with two treatment arms. Six hundred and sixty five Hispanics 50 years and older were recruited from 24 colonias (neighborhoods) in the Lower Rio Grande Valley of the Texas-Mexico border. The interventions were a small media print intervention (SMPI) (including DVD and flipchart), and a tailored interactive multimedia intervention (TIMI) delivered on tablet computers. A no intervention group served as the comparison group. Data were collected between 2007 and 2009 and analyzed between 2009 and 2013. Measures assessed CRCS behavior, self-efficacy, knowledge, and other psychosocial constructs related to CRCS and targeted through VLP. Among participants reached for follow-up, 18.9 % in the SMPI group, 13.3 % in the TIMI group, and 11.9 % in the comparison group completed CRCS. Intent-to-treat analysis showed that 13.6 % in the SMPI group, 10.2 % in the TIMI group, and 10.8 % in the comparison group completed CRCS. These differences were not statistically significant. Results indicated that there are no significant differences in CRCS uptake between groups. C1 [Fernandez, Maria E.; Savas, Lara S.; Krasny, Sarah; Vernon, Sally W.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Hlth Promot & Prevent Res, Houston, TX 77030 USA. [Carmack, Chakema C.] Univ Houston, Dept Educ Psychol, Coll Educ, Houston, TX USA. [Chan, Wenyaw] Univ Texas Sch Publ Hlth, Dept Biostat, Houston, TX USA. [Lairson, David R.] Univ Texas Sch Publ Hlth, Div Management Policy & Community Hlth, Houston, TX USA. [Byrd, Theresa L.] Texas Tech Univ, Hlth Sci Ctr, Dept Publ Hlth, Lubbock, TX 79430 USA. [Wilson, Katherine M.] Ctr Dis Control & Prevent, Epidemiol & Appl Res Branch, Div Canc Prevent & Control, Atlanta, GA USA. [Arvey, Sarah R.] Livestrong Fdn, Austin, TX USA. RP Fernandez, ME (reprint author), Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Hlth Promot & Prevent Res, 7000 Fannin St,Suite 2558, Houston, TX 77030 USA. EM maria.e.fernandez@uth.tmc.edu NR 35 TC 1 Z9 1 U1 2 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-5243 EI 1573-7225 J9 CANCER CAUSE CONTROL JI Cancer Causes Control PD JAN PY 2015 VL 26 IS 1 BP 1 EP 10 DI 10.1007/s10552-014-0472-5 PG 10 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA AY0JA UT WOS:000347281800001 PM 25466604 ER PT J AU Ford, ES Murphy, LB Khavjou, O Giles, WH Holt, JB Croft, JB AF Ford, Earl S. Murphy, Louise B. Khavjou, Olga Giles, Wayne H. Holt, James B. Croft, Janet B. TI Total and State-Specific Medical and Absenteeism Costs of COPD Among Adults Aged >= 18 Years in the United States for 2010 and Projections Through 2020 SO CHEST LA English DT Article ID OBSTRUCTIVE PULMONARY-DISEASE; CARE; MANAGEMENT; HOUSEHOLD; THERAPY AB BACKGROUND: COPD remains a leading cause of morbidity and mortality. The objectives of this study were to estimate (1) national US COPD-attributable annual medical costs by payer (direct) and absenteeism (indirect) in 2010 and projected medical costs through 2020 and (2) state-specific COPD-attributable medical and absenteeism costs in 2010. METHODS: We used the 2006-2010 Medical Expenditure Panel Survey, the 2004 National Nursing Home Survey, and 2010 Centers for Medicare and Medicaid Services data to generate cost estimates and 2010 census data to project medical costs through 2020. RESULTS: In 2010, total national medical costs attributable to COPD and its sequelae were estimated at $32.1 billion, and total absenteeism costs were $3.9 billion, for a total burden of COPD-attributable costs of $36 billion. An estimated 16.4 million days of work were lost because of COPD. Of the medical costs, 18% was paid for by private insurance, 51% by Medicare, and 25% by Medicaid. National medical costs are projected to increase from $32.1 billion in 2010 to $49.0 billion in 2020. Total state-specific costs in 2010 ranged from $49.1 million in Wyoming to $2.8 billion in California: medical costs ranged from $42.5 million in Alaska to $2.5 billion in Florida and absenteeism costs ranged from $8.4 million in Wyoming to $434.0 million in California. CONCLUSIONS: Costs attributable to COPD and its sequelae are substantial and are projected to increase through 2020. Evidence-based interventions that prevent tobacco use and reduce the clinical complications of COPD may result in potential decreased COPD-attributable costs. C1 [Ford, Earl S.; Murphy, Louise B.; Giles, Wayne H.; Holt, James B.; Croft, Janet B.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Atlanta, GA 30341 USA. [Khavjou, Olga] RTI Int, Res Triangle Pk, NC USA. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy,MS F78, Atlanta, GA 30341 USA. EM eford@cdc.gov FU Centers for Disease Control and Prevention [200-2008-27958-0002 task order 00006] FX This work was supported by the Centers for Disease Control and Prevention [Contract No. 200-2008-27958-0002 task order 00006]. NR 30 TC 59 Z9 59 U1 4 U2 8 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD JAN PY 2015 VL 147 IS 1 BP 31 EP 45 DI 10.1378/chest.14-0972 PG 15 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA AY3AH UT WOS:000347456500022 PM 25058738 ER PT J AU Ford, ES AF Ford, Earl S. TI Urinary Albumin-Creatinine Ratio, Estimated Glomerular Filtration Rate, and All-Cause Mortality Among US Adults With Obstructive Lung Function SO CHEST LA English DT Article ID KIDNEY-DISEASE MEASURES; STAGE RENAL-DISEASE; COLLABORATIVE METAANALYSIS; CARDIOVASCULAR-DISEASE; POPULATION COHORTS; COST-EFFECTIVENESS; UNITED-STATES; PULMONARY-DISEASE; NATIONAL-HEALTH; RISK-FACTOR AB BACKGROUND: Elevated urinary albumin-creatinine ratio (UACR) and decreased estimated glomerular filtration rate (eGFR) predict all-cause mortality, but whether these markers of kidney damage and function do so in adults with obstructive lung function (OLF) is unclear. The objective of this study was to examine the associations between UACR and eGFR and all-cause mortality in adults with OLF. METHODS: Data of 5,711 US adults aged 40 to 79 years, including 1,390 adults with any OLF who participated in the National Health and Nutrition Examination Survey III (1988-1994), were analyzed. Mortality follow-up was conducted through 2006. RESULTS: During the median follow-up of 13.7 years, 650 adults with OLF died. Aft er maximal adjustment, mean levels of UACR were higher in adults with moderate-severe OLF (7.5 mg/g; 95% CI, 6.7-8.5) than in adults with normal pulmonary function (6.2 mg/g; 95% CI, 5.8-6.6) (P = .003) and mild OLF (6.2 mg/g; 95% CI, 5.5-6.9) (P = .014). Adjusted mean levels of eGFR were lower in adults with moderate-severe OLF (87.6 mL/min/1.73 m(2); 95% CI, 86.0-89.1) than in adults with normal lung function (89.6 mL/min/1.73 m(2); 95% CI, 88.9-90.3) (P = .015). Among adults with OLF, hazard ratios for all-cause mortality increased as levels of UACR, modeled as categorical or continuous variables, increased (maximally adjusted hazard ratio for quintile 5 vs 1: 2.23; 95% CI, 1.56-3.18). eGFR, modeled as a continuous variable but not as quintiles, was significantly associated with mortality. CONCLUSIONS: UACR and eGFR, in continuous form, were associated with all-cause mortality among US adults with OLF. C1 [Ford, Earl S.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Atlanta, GA 30341 USA. RP Ford, ES (reprint author), Ctr Dis Control & Prevent, 4770 Buford Hwy,MS F78, Atlanta, GA 30341 USA. EM eford@cdc.gov FU Intramural CDC HHS [CC999999] NR 33 TC 3 Z9 4 U1 0 U2 4 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD JAN PY 2015 VL 147 IS 1 BP 56 EP 67 DI 10.1378/chest.13-2482 PG 12 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA AY3AH UT WOS:000347456500024 PM 25079336 ER PT J AU Nelson, C Elmendorf, S Mead, P AF Nelson, Christina Elmendorf, Sarah Mead, Paul TI Neoplasms Misdiagnosed as "Chronic Lyme Disease" SO JAMA INTERNAL MEDICINE LA English DT Letter ID THERAPY; DEATH C1 [Nelson, Christina; Mead, Paul] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Elmendorf, Sarah] Upstate Infect Dis Associates, Albany, NY USA. RP Nelson, C (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, 3156 Rampart Rd,Mail Stop P-02, Ft Collins, CO 80521 USA. EM wje1@cdc.gov NR 5 TC 6 Z9 6 U1 1 U2 7 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD JAN PY 2015 VL 175 IS 1 BP 132 EP 133 DI 10.1001/jamainternmed.2014.5426 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA AY1BM UT WOS:000347328500028 PM 25365479 ER PT J AU Yang, QH Zhang, ZF Hu, FB AF Yang, Quanhe Zhang, Zefeng Hu, Frank B. TI Why Are We Consuming So Much Sugar Despite Knowing Too Much Can Harm Us? Reply SO JAMA INTERNAL MEDICINE LA English DT Letter ID SWEETENED BEVERAGES; RISK; CONSUMPTION; DISEASE C1 [Yang, Quanhe; Zhang, Zefeng] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Atlanta, GA 30033 USA. [Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. RP Zhang, ZF (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, 4770 Buford Hwy,MS F-72, Atlanta, GA 30033 USA. EM hwv0@cdc.gov FU Intramural CDC HHS [CC999999] NR 6 TC 0 Z9 0 U1 1 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6106 EI 2168-6114 J9 JAMA INTERN MED JI JAMA Intern. Med. PD JAN PY 2015 VL 175 IS 1 BP 146 EP 146 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA AY1BM UT WOS:000347328500042 PM 25560953 ER PT J AU Brosco, JP Grosse, SD Ross, LF AF Brosco, Jeffrey P. Grosse, Scott D. Ross, Lainie Friedman TI Universal State Newborn Screening Programs Can Reduce Health Disparities SO JAMA PEDIATRICS LA English DT Editorial Material ID DISEASE C1 [Brosco, Jeffrey P.] Univ Miami, Mailman Ctr Child Dev, Dept Pediat, Miami, FL 33101 USA. [Grosse, Scott D.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Ross, Lainie Friedman] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA. [Ross, Lainie Friedman] Univ Chicago, MacLean Ctr Clin Med Eth, Chicago, IL 60637 USA. RP Brosco, JP (reprint author), Univ Miami, Mailman Ctr Child Dev, Dept Pediat, POB 016820,D-820, Miami, FL 33101 USA. EM jbrosco@miami.edu FU Intramural CDC HHS [CC999999]; NCATS NIH HHS [UL1 TR000430] NR 7 TC 5 Z9 7 U1 0 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 2168-6203 EI 2168-6211 J9 JAMA PEDIATR JI JAMA Pediatr. PD JAN PY 2015 VL 169 IS 1 BP 7 EP 8 DI 10.1001/jamapediatrics.2014.2465 PG 2 WC Pediatrics SC Pediatrics GA AY1JI UT WOS:000347349300004 PM 25402722 ER PT J AU Larson, S Gould, DW AF Larson, Sharon Gould, Deborah W. TI Introduction to Special Section: Behavioral Health and Disasters-Planning for the Next Time SO JOURNAL OF BEHAVIORAL HEALTH SERVICES & RESEARCH LA English DT Article C1 [Larson, Sharon; Gould, Deborah W.] Subst Abuse & Mental Hlth Serv Adm, Atlanta, GA 30365 USA. [Gould, Deborah W.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Gould, DW (reprint author), Subst Abuse & Mental Hlth Serv Adm, Atlanta, GA 30365 USA. EM dgw8@cdc.gov FU Intramural CDC HHS [CC999999] NR 6 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1094-3412 EI 1556-3308 J9 J BEHAV HEALTH SER R JI J. Behav. Health Serv. Res. PD JAN PY 2015 VL 42 IS 1 BP 3 EP 5 DI 10.1007/s11414-014-9444-5 PG 3 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA AY2KW UT WOS:000347420100002 PM 25344326 ER PT J AU Gould, DW Teich, JL Pemberton, MR Pierannunzi, C Larson, S AF Gould, Deborah W. Teich, Judith L. Pemberton, Michael R. Pierannunzi, Carol Larson, Sharon TI Behavioral Health in the Gulf Coast Region Following the Deepwater Horizon Oil Spill: Findings from Two Federal Surveys SO JOURNAL OF BEHAVIORAL HEALTH SERVICES & RESEARCH LA English DT Article ID EXXON-VALDEZ; DISASTER AB This article summarizes findings from two large-scale, population-based surveys conducted by Substance Abuse and Mental Health Services Administration (SAMHSA) and Centers for Disease Control and Prevention (CDC) in the Gulf Coast region following the 2010 Deepwater Horizon oil spill, to measure the prevalence of mental and substance use disorders, chronic health conditions, and utilization of behavioral health services. Although many area residents undoubtedly experienced increased levels of anxiety and stress following the spill, findings suggest only modest or minimal changes in behavioral health at the aggregate level before and after the spill. The studies do not address potential long-term effects of the spill on physical and behavioral health nor did they target subpopulations that might have been most affected by the spill. Resources mobilized to reduce the economic and behavioral health impacts of the spill on coastal residents-including compensation for lost income from BP and increases in available mental health services-may have resulted in a reduction in potential mental health problems. C1 [Gould, Deborah W.; Teich, Judith L.; Pierannunzi, Carol] Subst Abuse & Mental Hlth Serv Adm, Ctr Behav Hlth Stat & Qual, Rockville, MD 20849 USA. [Larson, Sharon] Ctr Dis Control & Prevent, Div Hlth Informat & Surveillance, Atlanta, GA USA. [Pemberton, Michael R.] RTI Int, New Orleans, LA USA. RP Teich, JL (reprint author), Subst Abuse & Mental Hlth Serv Adm, Ctr Behav Hlth Stat & Qual, Rockville, MD 20849 USA. EM dgould@cdc.gov; Judith.teich@samhsa.hhs.gov; pemberton@rti.org; CPierannunzi@cdc.gov; sharon.larson@samhsa.hhs.gov FU Intramural CDC HHS [CC999999] NR 21 TC 1 Z9 1 U1 2 U2 25 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1094-3412 EI 1556-3308 J9 J BEHAV HEALTH SER R JI J. Behav. Health Serv. Res. PD JAN PY 2015 VL 42 IS 1 BP 6 EP 22 DI 10.1007/s11414-014-9441-8 PG 17 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA AY2KW UT WOS:000347420100003 PM 25339594 ER PT J AU Fan, AZ Prescott, MR Zhao, GX Gotway, CA Galea, S AF Fan, Amy Z. Prescott, Marta R. Zhao, Guixiang Gotway, Carol A. Galea, Sandro TI Individual and Community-Level Determinants of Mental and Physical Health After the Deepwater Horizon Oil Spill: Findings from the Gulf States Population Survey SO JOURNAL OF BEHAVIORAL HEALTH SERVICES & RESEARCH LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; DISASTER VICTIMS SPEAK; EXXON-VALDEZ; PSYCHOLOGICAL IMPACTS; PRIME-MD; DEPRESSION; SEVERITY; RESILIENCE; ATTACHMENT; MORTALITY AB The 2010 Deepwater Horizon oil spill had enormous consequences on the environment. Prevalence of mental and physical health conditions among Gulf residents after the disaster, however, are still being assessed. The Gulf State Population Survey (GSPS) was a representative survey of 38,361 residents in four Gulf States and was conducted from December 2010 to December 2011. Analysis of the GSPS data showed that differences in individual characteristics and direct or indirect exposure to the disaster drove the individual-level variation in health outcomes (mental distress, physical distress, and depression). Direct exposure to the disaster itself was the most important determinant of health after this event. Selected county-level characteristics were not found to be significantly associated with any of our health indicators of interest. This study suggests that in the context of an overwhelming event, persons who are most directly affected through direct exposure should be the primary focus of any public health intervention effort. C1 [Fan, Amy Z.; Zhao, Guixiang; Gotway, Carol A.] Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Div Behav Surveillance, Publ Hlth Surveillance & Informat Program Off, Atlanta, GA 30333 USA. [Prescott, Marta R.; Galea, Sandro] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA. RP Fan, AZ (reprint author), Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Div Behav Surveillance, Publ Hlth Surveillance & Informat Program Off, Atlanta, GA 30333 USA. EM afan@cdc.gov NR 53 TC 6 Z9 6 U1 2 U2 22 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1094-3412 EI 1556-3308 J9 J BEHAV HEALTH SER R JI J. Behav. Health Serv. Res. PD JAN PY 2015 VL 42 IS 1 BP 23 EP 41 DI 10.1007/s11414-014-9418-7 PG 19 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA AY2KW UT WOS:000347420100004 PM 25124651 ER PT J AU Fan, AZ Prescott, MR Zhao, GX Gotway, CA Galea, S AF Fan, Amy Z. Prescott, Marta R. Zhao, Guixang Gotway, Carol A. Galea, Sandro TI Individual and Community-Level Determinants of Mental and Physical Health After the Deepwater Horizon Oil Spill: Findings from Two Federal Surveys (vol 42, pg 23, 2015) SO JOURNAL OF BEHAVIORAL HEALTH SERVICES & RESEARCH LA English DT Correction C1 [Fan, Amy Z.; Zhao, Guixang; Gotway, Carol A.] Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Publ Hlth Surveillance & Informat Program Off, Div Behav Surveillance, Atlanta, GA 30333 USA. [Prescott, Marta R.; Galea, Sandro] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA. RP Fan, AZ (reprint author), Ctr Dis Control & Prevent, Off Surveillance Epidemiol & Lab Serv, Publ Hlth Surveillance & Informat Program Off, Div Behav Surveillance, Atlanta, GA 30333 USA. EM afan@cdc.gov NR 1 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1094-3412 EI 1556-3308 J9 J BEHAV HEALTH SER R JI J. Behav. Health Serv. Res. PD JAN PY 2015 VL 42 IS 1 BP 123 EP 123 DI 10.1007/s11414-014-9446-3 PG 1 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA AY2KW UT WOS:000347420100013 PM 25352479 ER PT J AU Lockey, JE Redlich, CA Streicher, R Pfahles-Hutchens, A Hakkinen, PJ Ellison, GL Harber, P Utell, M Holland, J Comai, A White, M AF Lockey, James E. Redlich, Carrie A. Streicher, Robert Pfahles-Hutchens, Andrea Hakkinen, Pertti (Bert) J. Ellison, Gary L. Harber, Philip Utell, Mark Holland, John Comai, Andrew White, Marc TI Isocyanates and Human Health Multistakeholder Information Needs and Research Priorities SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID METHYLENE DIPHENYL DIISOCYANATE; COLLISION REPAIR INDUSTRY; OCCUPATIONAL ASTHMA; TOLUENE DIISOCYANATE; EXPOSURE LIMITS; SKIN EXPOSURE; POLYURETHANE; SURVEILLANCE AB Objectives: To outline the knowledge gaps and research priorities identified by a broad base of stakeholders involved in the planning and participation of an international conference and research agenda workshop on isocyanates and human health held in Potomac, Maryland, in April 2013. Methods: A multimodal iterative approach was used for data collection including preconference surveys, review of a 2001 consensus conference on isocyanates, oral and poster presentations, focused break-out sessions, panel discussions, and postconference research agenda workshop. Results: Participants included representatives of consumer and worker health, health professionals, regulatory agencies, academic and industry scientists, labor, and trade associations. Conclusions: Recommendations were summarized regarding knowledge gaps and research priorities in the following areas: worker and consumer exposures; toxicology, animal models, and biomarkers; human cancer risk; environmental exposure and monitoring; and respiratory epidemiology and disease, and occupational health surveillance. C1 [Lockey, James E.] Univ Cincinnati, Div Occupat & Environm Med, Dept Environm Hlth, Pulm Div,Dept Internal Med,Coll Med, Cincinnati, OH 45267 USA. [Redlich, Carrie A.] Yale Univ, Sch Med, Yale Occupat & Environm Med, New Haven, CT USA. [Streicher, Robert] NIOSH, Div Appl Res & Technol, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. [Pfahles-Hutchens, Andrea] US EPA, Risk Assessment Div, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA. [Hakkinen, Pertti (Bert) J.] NIH, Off Clin Toxicol, Specialized Informat Serv, Natl Lib Med, Bethesda, MD 20892 USA. [Ellison, Gary L.] NCI, Epidemiol & Genom Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Harber, Philip] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Tucson, AZ USA. [Utell, Mark] Univ Rochester, Med Ctr, Rochester, NY 14627 USA. [Holland, John] Holland Associates, Palo Alto, CA USA. [Comai, Andrew] UAW Hlth & Safety, Int Union, Detroit, MI USA. [White, Marc] Univ British Columbia, Dept Family Practice, Vancouver, BC V5Z 1M9, Canada. [White, Marc] Canadian Inst Relief Pain & Disabil, Vancouver, BC, Canada. RP Lockey, JE (reprint author), Univ Cincinnati, Coll Med, Div Occupat & Environm Med, Dept Environm Hlth, 3223 Eden Ave, Cincinnati, OH 45267 USA. EM lockeyje@ucmail.uc.edu RI White, Marc/N-8404-2015; Hakkinen, Pertti/G-4803-2016; OI Hakkinen, Pertti/0000-0002-8295-9738; White, Marc/0000-0001-7623-1268 FU National Institutes of Health, National Cancer Institute; Canadian Institutes for Health Research-Institute of Cancer Research; University of Cincinnati College of Medicine FX National Institutes of Health, National Cancer Institute; Canadian Institutes for Health Research-Institute of Cancer Research; and University of Cincinnati College of Medicine. NR 30 TC 3 Z9 3 U1 3 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JAN PY 2015 VL 57 IS 1 BP 44 EP 51 DI 10.1097/JOM.0000000000000278 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY3IP UT WOS:000347477900010 PM 25563538 ER PT J AU Halldin, CN Reed, WR Joy, GJ Colinet, JF Rider, JP Petsonk, EL Abraham, JL Wolfe, AL Storey, E Laney, AS AF Halldin, Cara N. Reed, William R. Joy, Gerald J. Colinet, Jay F. Rider, James P. Petsonk, Edward L. Abraham, Jerrold L. Wolfe, Anita L. Storey, Eileen Laney, A. Scott TI Debilitating Lung Disease Among Surface Coal Miners With No Underground Mining Tenure SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID UNITED-STATES; PNEUMOCONIOSIS AB Objective: To characterize exposure histories and respiratory disease among surface coal miners identified with progressive massive fibrosis from a 2010 to 2011 pneumoconiosis survey. Methods: Job history, tenure, and radiograph interpretations were verified. Previous radiographs were reviewed when available. Telephone follow-up sought additional work and medical history information. Results: Among eight miners who worked as drill operators or blasters for most of their tenure (median, 35.5 years), two reported poor dust control practices, working in visible dust clouds as recently as 2012. Chest radiographs progressed to progressive massive fibrosis in as few as 11 years. One miner's lung biopsy demonstrated fibrosis and interstitial accumulation of macrophages containing abundant silica, aluminum silicate, and titanium dust particles. Conclusions: Overexposure to respirable silica resulted in progressive massive fibrosis among current surface coal miners with no underground mining tenure. Inadequate dust control during drilling/blasting is likely an important etiologic factor. C1 [Halldin, Cara N.; Petsonk, Edward L.; Wolfe, Anita L.; Storey, Eileen; Laney, A. Scott] NIOSH, Surveillance Branch, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV USA. [Reed, William R.; Joy, Gerald J.; Colinet, Jay F.; Rider, James P.] NIOSH, Off Mine Safety & Hlth Res, Ctr Dis Control & Prevent, Pittsburgh, PA USA. [Abraham, Jerrold L.] SUNY Upstate Med Univ, Dept Pathol, Syracuse, NY 13210 USA. RP Halldin, CN (reprint author), Surveillance Branch, Div Resp Dis Studies, 1095 Willowdale Rd,Mail Stop HG900, Morgantown, WV 26505 USA. EM challdin@cdc.gov OI Reed, Randy/0000-0003-2749-4648 FU Centers for Disease Control and Prevention's National Institute for Occupational Safety and Health; State University of New York (SUNY) Upstate Medical University; New York State Development's Division of Science, Technology and Innovation FX The Centers for Disease Control and Prevention's National Institute for Occupational Safety and Health and State University of New York (SUNY) Upstate Medical University supported the salaries of the authors, and no other funding was obtained. This work was performed as part of their work; no nongovernmental funding supported this work. The analytical electron microscope instrumentation at SUNY was partially supported by a grant from New York State Development's Division of Science, Technology and Innovation. NR 16 TC 8 Z9 9 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JAN PY 2015 VL 57 IS 1 BP 62 EP 67 DI 10.1097/JOM.0000000000000302 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY3IP UT WOS:000347477900013 PM 25563541 ER PT J AU Rempel, D Gerr, F Harris-Adamson, C Hegmann, KT Thiese, MS Kapellusch, J Garg, A Burt, S Bao, S Silverstein, B Merlino, L Dale, AM Evanoff, B AF Rempel, David Gerr, Fred Harris-Adamson, Carisa Hegmann, Kurt T. Thiese, Matthew S. Kapellusch, Jay Garg, Arun Burt, Susan Bao, Stephen Silverstein, Barbara Merlino, Linda Dale, Ann Marie Evanoff, Bradley TI Personal and Workplace Factors and Median Nerve Function in a Pooled Study of 2396 US Workers SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID CARPAL-TUNNEL-SYNDROME; RISK-FACTORS; COMPUTER USERS; PREVALENCE; CONDUCTION; INDUSTRY; POPULATION; DISORDERS; COHORT; JOB AB Objective: Evaluate associations between personal and workplace factors and median nerve conduction latency at the wrist. Methods: Baseline data on workplace psychosocial and physical exposures were pooled from four prospective studies of production and service workers (N = 2396). During the follow-up period, electrophysiologic measures of median nerve function were collected at regular intervals. Results: Significant adjusted associations were observed between age, body mass index, sex, peak hand force, duration of forceful hand exertions, Threshold Limit Value for Hand Activity Limit, forceful repetition rate, wrist extension, and decision latitude on median nerve latencies. Conclusions: Occupational and nonoccupational factors have adverse effects on median nerve function. Measuring median nerve function eliminates possible reporting bias that may affect symptom-based carpal tunnel syndrome case definitions. These results suggest that previously observed associations between carpal tunnel syndrome and occupational factors are not the result of such reporting bias. C1 [Rempel, David; Harris-Adamson, Carisa] Univ Calif San Francisco, Div Occupat & Environm Med, Richmond, CA 94804 USA. [Gerr, Fred; Merlino, Linda] Univ Iowa, Dept Occupat & Environm Hlth, Coll Publ Hlth, Iowa City, IA 52242 USA. [Hegmann, Kurt T.; Thiese, Matthew S.] Univ Utah, Rocky Mt Ctr Occupat & Environm Hlth, Salt Lake City, UT USA. [Kapellusch, Jay; Garg, Arun] Univ Wisconsin Milwaukee, Dept Occupat Sci & Technol, Milwaukee, WI 53211 USA. [Burt, Susan] NIOSH, Cincinnati, OH 45226 USA. [Bao, Stephen; Silverstein, Barbara] Washington State Dept Labor & Ind, Safety & Hlth Assessment & Res Prevent Program, Olympia, WA 98504 USA. [Dale, Ann Marie; Evanoff, Bradley] Washington Univ, Div Gen Med Sci, Sch Med, St Louis, MO 63130 USA. RP Rempel, D (reprint author), Univ Calif San Francisco, Div Occupat & Environm Med, 1301 South 46th St Bldg 163, Richmond, CA 94804 USA. EM david.rempel@ucsf.edu OI Evanoff, Bradley A./0000-0003-0085-333X FU Center for Disease Control/National Institute for Occupational Safety and Health [R01OH009712]; Washington University Institute of Clinical and Translational Sciences Award from the National Center for Advancing Translational Sciences of the National Institutes of Health [UL1 TR000448] FX This study was supported in part by research funding from the Center for Disease Control/National Institute for Occupational Safety and Health (R01OH009712) and the Washington University Institute of Clinical and Translational Sciences Award (UL1 TR000448) from the National Center for Advancing Translational Sciences of the National Institutes of Health. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health. NR 32 TC 1 Z9 1 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1076-2752 EI 1536-5948 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JAN PY 2015 VL 57 IS 1 BP 98 EP 104 DI 10.1097/JOM.0000000000000312 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY3IP UT WOS:000347477900018 PM 25563546 ER PT J AU Connor, MJ Kraft, C Mehta, AK Varkey, JB Lyon, GM Crozier, I Stroeher, U Ribner, BS Franch, HA AF Connor, Michael J., Jr. Kraft, Colleen Mehta, Aneesh K. Varkey, Jay B. Lyon, G. Marshall Crozier, Ian Stroeher, Ute Ribner, Bruce S. Franch, Harold A. TI Successful Delivery of RRT in Ebola Virus Disease SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID ACUTE KIDNEY INJURY; CRITICALLY-ILL PATIENTS; RENAL REPLACEMENT THERAPY; FAILURE; HEMODIALYSIS; SUPPORT; UNIT; CARE AB AKI has been observed in cases of Ebola virus disease. We describe the protocol for the first known successful delivery of RRT with subsequent renal recovery in a patient with Ebola virus disease treated at Emory University Hospital, in Atlanta, Georgia. Providing RRT in Ebola virus disease is complex and requires meticulous attention to safety for the patient, healthcare workers, and the community. We specifically describe measures to decrease the risk of transmission of Ebola virus disease and report pilot data demonstrating no detectable Ebola virus genetic material in the spent RRT effluent waste. This article also proposes clinical practice guidelines for acute RRT in Ebola virus disease. C1 [Connor, Michael J., Jr.] Emory Univ, Sch Med, Div Pulm Allergy & Crit Care, Dept Med, Atlanta, GA 30308 USA. [Connor, Michael J., Jr.; Franch, Harold A.] Emory Univ, Sch Med, Div Pulm Allergy & Crit Care, Div Renal Med, Atlanta, GA 30308 USA. [Kraft, Colleen; Mehta, Aneesh K.; Varkey, Jay B.; Lyon, G. Marshall; Ribner, Bruce S.] Emory Univ, Sch Med, Div Pulm Allergy & Crit Care, Div Infect Dis, Atlanta, GA 30308 USA. [Kraft, Colleen] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30308 USA. [Crozier, Ian] Mulago Hosp Complex, Infect Dis Inst, Kampala, Uganda. [Stroeher, Ute] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Franch, Harold A.] Atlanta Dept Vet Affairs Med Ctr, Res Serv, Decatur, GA USA. RP Connor, MJ (reprint author), Emory Univ, Sch Med, Div Pulm Allergy & Crit Care, Dept Med, 550 Peachtree St NE,Davis Fischer Bldg, Atlanta, GA 30308 USA. EM michael.connor@emory.edu; hfranch@emory.edu RI Mehta, Aneesh/B-8054-2012; OI Mehta, Aneesh/0000-0002-6552-9162; Franch, Harold/0000-0003-1392-3798; Connor, Michael/0000-0001-7613-5583 NR 26 TC 30 Z9 31 U1 1 U2 13 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1046-6673 EI 1533-3450 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD JAN PY 2015 VL 26 IS 1 BP 31 EP 37 DI 10.1681/ASN.2014111057 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA AY4QS UT WOS:000347564000007 PM 25398785 ER PT J AU Wedemeyer, H Dore, GJ Ward, JW AF Wedemeyer, H. Dore, G. J. Ward, J. W. TI Estimates on HCV disease burden worldwide - filling the gaps SO JOURNAL OF VIRAL HEPATITIS LA English DT Article DE diagnosis; disease burden; epidemiology; hepatitis C; hepatitis C virus; prevalence; strategy; sustained viral response; therapies; total infections; treatment ID C VIRUS HCV; NEED DIFFERENT MODELS; STAGE LIVER-DISEASE; JVH SPECIAL-ISSUE; HEPATITIS-C; STRATEGIES; PREVALENCE; INFECTION; MORTALITY; MANAGE AB Hepatitis C is caused by infection with the hepatitis C virus (HCV) and represents a major global health burden. Persistent HCV infection can lead to progressive liver disease with the development of liver cirrhosis and hepatocellular carcinoma, possibly accounting for up to 0.5 million deaths every year. Treatment of HCV infection is undergoing a profound and radical change. As new treatments are extremely safe and effective, there are virtually no medical reasons to withhold therapy. Yet, the new therapies are expensive. As resources are limited, solid data to estimate the disease burden caused by HCV are urgently needed. Epidemiology data and disease burden analyses for 16 countries are presented. For almost all countries, the peak of HCV-related cirrhosis, hepatocellular carcinoma and liver-related death is a decade or more away. However, a surprising heterogeneity in country-specific HCV-associated disease burden exists. Also, HCV diagnosis and treatment uptake varied markedly between countries. A consistent finding was that a reduction of HCV liver-related mortality is dependent on access to therapy. Increasing efficacy of therapy alone with a constant numbers of treatments will not have a major impact on the HCV-related disease burden. The data presented here should inform public health policy and help drive advocacy for enhanced strategic investment and action. HCV kills patients, and the disease burden will continue to rise in most countries unless action is taken soon. Chronic HCV is a curable infection and a reversible liver disease. Fortunately, the tools to eliminate HCV are now available. C1 [Wedemeyer, H.] Hannover Ctr Internal Med, Hannover, Germany. [Dore, G. J.] Univ New S Wales, Kirby Inst, Sydney, NSW, Australia. [Ward, J. W.] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA USA. RP Wedemeyer, H (reprint author), Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Carl Neuberg Str, D-130625 Hannover, Germany. EM wedemeyer.heiner@mh-hannover.de FU Abbott; BMS; Gilead; Merck; Novartis; Roche; Roche Diagnostics; Siemens; Janssen; Bristol-Myers Squibb; AbbVie; Vertex; Boeringher Ingelheim FX H Wedemeyer received Honoraria from Abbott, AbbVie, Achillon, Biolex, BMS, Boerhinger Ingelheim, Eiger Pharmaceuticals, Falk Foundations, Gilead, ITS, J&J/Janssen-Cilag/Janssen TE, Medgenics, Merck/Schering-Plough, Novartis, Novira, Roche, Roche Diagnostics, Siemens, Transgene, ViiV; and has received research grants from Abbott, BMS, Gilead, Merck, Novartis, Roche, Roche Diagnostics, and Siemens. G. J. Dore has Advisory Board Membership: Roche, Merck, Janssen, Gilead, Bristol-Myers Squibb, AbbVie Honorarium: Roche, Merck, Janssen, Gilead, Bristol-Myers Squibb, AbbVie Research Grants: Roche, Merck, Janssen, Gilead, Bristol-Myers Squibb, Vertex, Boeringher Ingelheim, AbbVie Travel Sponsorship: Roche, Merck, Janssen, Gilead, Bristol-Myers Squibb. J. W. Ward has no conflict of interests. NR 18 TC 38 Z9 38 U1 3 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1352-0504 EI 1365-2893 J9 J VIRAL HEPATITIS JI J. Viral Hepatitis PD JAN PY 2015 VL 22 SU 1 BP 1 EP 5 DI 10.1111/jvh.12371 PG 5 WC Gastroenterology & Hepatology; Infectious Diseases; Virology SC Gastroenterology & Hepatology; Infectious Diseases; Virology GA AY0TT UT WOS:000347310500001 PM 25560838 ER PT J AU Demissie, Z Lowry, R Eaton, DK Nihiser, AJ AF Demissie, Zewditu Lowry, Richard Eaton, Danice K. Nihiser, Allison J. TI Trends in Weight Management Goals and Behaviors Among 9th-12th Grade Students: United States, 1999-2009 SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Adolescent; Weight control; Trend; Gender differences; Ethnic groups ID NONOVERWEIGHT ADOLESCENTS; DIETARY-INTAKE; PROJECT EAT; OBESITY; OVERWEIGHT; PREVENTION; RECOMMENDATIONS; RELIABILITY; DISORDERS; CHILDHOOD AB To examine trends in weight management goals and behaviors among U.S. high school students during 1999-2009. Data from six biennial cycles (1999-2009) of the national Youth Risk Behavior Survey were analyzed. Cross-sectional, nationally representative samples of 9th-12th grade students (approximately 14,000 students/cycle) completed self-administered questionnaires. Logistic regression models adjusted for grade, race/ethnicity, and obesity were used to test for trends in weight management goals and behaviors among subgroups of students. Combined prevalences and trends differed by sex and by race/ethnicity and weight status within sex. During 1999-2009, the prevalence of female students trying to gain weight decreased (7.6-5.7 %). Among female students trying to lose or stay the same weight, prevalences decreased for eating less (69.6-63.2 %); fasting (23.3-17.6 %); using diet pills/powders/liquids (13.7-7.8 %); and vomiting/laxatives (9.5-6.6 %) for weight control. During 1999-2009, the prevalence of male students trying to lose weight increased (26.1-30.5 %). Among male students trying to lose or stay the same weight, the prevalence of exercising to control weight did not change during 1999-2003 and then increased (74.0-79.1 %) while the prevalence of taking diet pills/powders/liquids for weight control decreased (6.9-5.1 %) during 1999-2009. Weight management goals and behaviors changed during 1999-2009 and differed by subgroup. To combat the use of unhealthy weight control behaviors, efforts may be needed to teach adolescents about recommended weight management strategies and avoiding the risks associated with unhealthy methods. C1 [Demissie, Zewditu] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Demissie, Zewditu; Lowry, Richard; Eaton, Danice K.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div Adolescent, Atlanta, GA USA. [Demissie, Zewditu; Lowry, Richard; Eaton, Danice K.] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Sch Hlth, Atlanta, GA USA. [Nihiser, Allison J.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Atlanta, GA USA. RP Demissie, Z (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM izj5@cdc.gov NR 38 TC 2 Z9 2 U1 0 U2 13 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2015 VL 19 IS 1 BP 74 EP 83 DI 10.1007/s10995-014-1497-9 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY0OK UT WOS:000347295600010 PM 24781877 ER PT J AU McDonald, JA Mojarro Davila, O Sutton, PD Ventura, SJ AF McDonald, Jill A. Mojarro Davila, Octavio Sutton, Paul D. Ventura, Stephanie J. TI Cesarean Birth in the Border Region: A Descriptive Analysis Based on US Hispanic and Mexican Birth Certificates SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Reproductive health; Birth certificates; Population surveillance; Hispanic Americans; Mexico; Cesarean section AB Cesarean birth (CB) is more prevalent in the US-Mexico border region than among all US Hispanics. Comparable data from US and Mexican birth certificates can be used to compare prevalence and identify risk factors on either side of the border. Using 2009 US and Mexican birth certificates, we compared the characteristics of US Hispanic and Mexican CBs in six geographic subgroups: US and Mexican border counties/municipios, US and Mexican non-border counties/municipios and the US and Mexico overall. We also explored cesarean prevalence over time. During 2000-2009, CB rates increased from 22.1 to 31.6 % among US Hispanics and from 25.9 to 37.9 % among Hispanics in the US border region. 2009 rates were 44.5 % in Mexico and 43.1 % in the Mexican border region. In both countries, CB rates were similar for primiparas and multiparas. Higher education, being married and parity > 4 were associated with CB in Mexico; being married was associated in the US. Hispanic rates were higher in the US border than non-border region for all age groups. Along the border, cesarean rates for Hispanics were highest in Texas (43.5 %) and neighboring Tamaulipas (49.8 %). Higher cesarean prevalence in Mexico than in US Hispanics, while unexplained, is consistent with high prevalence in some Latin American countries. Higher cesarean prevalence among Hispanics in the US border region than among Hispanics nationwide cannot be explained by maternal age or parity. Medical indications are also unlikely to explain such high rates, which are undesirable for mothers and infants. C1 [McDonald, Jill A.] New Mexico State Univ, Coll Hlth & Social Serv, Las Cruces, NM 88003 USA. [McDonald, Jill A.] Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30333 USA. [Mojarro Davila, Octavio] CECOFIN SC, Mexico City, DF, Mexico. [Sutton, Paul D.; Ventura, Stephanie J.] Natl Ctr Hlth Stat, Div Vital Stat, Hyattsville, MD 20782 USA. RP McDonald, JA (reprint author), New Mexico State Univ, Coll Hlth & Social Serv, Las Cruces, NM 88003 USA. EM jillmcd@nmsu.edu NR 28 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2015 VL 19 IS 1 BP 112 EP 120 DI 10.1007/s10995-014-1501-4 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY0OK UT WOS:000347295600014 PM 24791973 ER PT J AU McDonald, JA Mojarro, O Sutton, PD Ventura, SJ AF McDonald, Jill A. Mojarro, Octavio Sutton, Paul D. Ventura, Stephanie J. TI Adolescent Births in the Border Region: A Descriptive Analysis Based on US Hispanic and Mexican Birth Certificates SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Adolescents; Birth certificates; Birth rates; Hispanic Americans; Mexico AB Adolescent childbearing adversely affects both mothers and infants. The birth rate for US adolescent women of Hispanic origin is higher than that for US adolescents overall. Birth rates among US Hispanic adolescents in the border region are higher than rates among other US Hispanic adolescents, and rates among Mexican border adolescents are higher than rates among other Mexican adolescents. We used binational birth certificate data for US Hispanic and Mexican adolescent women living inside the border region, elsewhere within the border states, and in the US and Mexico overall to compare birth rates and other health indicators among these groups. From 2000 to 2009, birth rates for 15-19 year-olds declined 19-28 % among US Hispanic geographic subgroups and 8-13 % among Mexican geographic subgroups; rates in the border region in 2009 were 73.8/1,000 women ages 15-19 for US Hispanics and 87.2/1,000 for Mexicans and were higher than rates in other US and Mexican subgroups, respectively. Less than one in five US Hispanic and Mexican adolescent mothers in the border region was married. About one in three delivered by cesarean. Late or no prenatal care was more prevalent among US Hispanic (17.6 %) than Mexican (14.3 %) border adolescents. Birth weight and gestational age outcomes were generally poorest in Texas border counties compared with border counties in other US states and in municipios of Mexican states bordering Texas. High birth rates and low prenatal care utilization among adolescents are problems along the US-Mexico border. C1 [McDonald, Jill A.] New Mexico State Univ, Coll Hlth & Social Serv, Las Cruces, NM 88003 USA. [McDonald, Jill A.] Ctr Dis Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30333 USA. [Mojarro, Octavio] CECOFIN SC, Mexico City, DF, Mexico. [Sutton, Paul D.; Ventura, Stephanie J.] Natl Ctr Hlth Stat, Div Vital Stat, Hyattsville, MD 20782 USA. RP McDonald, JA (reprint author), New Mexico State Univ, Coll Hlth & Social Serv, Las Cruces, NM 88003 USA. EM jillmcd@nmsu.edu NR 32 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2015 VL 19 IS 1 BP 128 EP 135 DI 10.1007/s10995-014-1503-2 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY0OK UT WOS:000347295600016 PM 24820518 ER PT J AU Polen, KND Sandhu, PK Honein, MA Green, KK Berkowitz, JM Pace, J Rasmussen, SA AF Polen, Kara N. D. Sandhu, Paramjit K. Honein, Margaret A. Green, Katie K. Berkowitz, Judy M. Pace, Jill Rasmussen, Sonja A. TI Knowledge and Attitudes of Adults towards Smoking in Pregnancy: Results from the HealthStyles (c) 2008 Survey SO MATERNAL AND CHILD HEALTH JOURNAL LA English DT Article DE Pregnancy; Knowledge; Attitudes; Smoking; Adverse outcomes ID INFANT-DEATH-SYNDROME; MATERNAL CIGARETTE-SMOKING; INTRAUTERINE GROWTH-RETARDATION; ENVIRONMENTAL TOBACCO-SMOKE; LOW-BIRTH-WEIGHT; OROFACIAL CLEFTS; PRENATAL SMOKING; PLACENTA PREVIA; SPONTANEOUS-ABORTION; FETAL-GROWTH AB Smoking during pregnancy is causally associated with many adverse health outcomes. Quitting smoking, even late in pregnancy, improves some outcomes. Among adults in general and reproductive-aged women, we sought to understand knowledge and attitudes towards prenatal smoking and its effects on pregnancy outcomes. Using data from the 2008 HealthStylesA (c) survey, we assessed knowledge and attitudes about prenatal smoking and smoking cessation. We classified respondents as having high knowledge if they gave a parts per thousand yen5 correct responses to six knowledge questions regarding the health effects of prenatal smoking. We calculated frequencies of correct responses to assess knowledge about prenatal smoking and estimated relative risk to examine knowledge by demographic and lifestyle factors. Only 15 % of all respondents and 23 % of reproductive-aged women had high knowledge of the adverse effects of prenatal smoking on pregnancy outcomes. Preterm birth and low birth weight were most often recognized as adverse outcomes associated with prenatal smoking. Nearly 70 % of reproductive-aged women smokers reported they would quit smoking if they became pregnant without any specific reasons from their doctor. Few respondents recognized the benefits of quitting smoking after the first trimester of pregnancy. Our results suggest that many women lack knowledge regarding the increased risks for adverse outcomes associated with prenatal smoking. Healthcare providers should follow the recommendations provided by the American Congress of Obstetricians and Gynecologists, which include educating women about the health risks of prenatal smoking and the benefits of quitting. Healthcare providers should emphasize quitting smoking even after the first trimester of pregnancy. C1 [Polen, Kara N. D.; Honein, Margaret A.; Green, Katie K.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Polen, Kara N. D.; Sandhu, Paramjit K.; Honein, Margaret A.; Green, Katie K.; Berkowitz, Judy M.; Pace, Jill; Rasmussen, Sonja A.] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA. [Sandhu, Paramjit K.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Berkowitz, Judy M.] Battelle Mem Inst, Atlanta, GA USA. [Pace, Jill; Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Off Infect Dis, Atlanta, GA 30333 USA. RP Polen, KND (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd NE,MS E-86, Atlanta, GA 30333 USA. EM fvc1@cdc.gov FU Intramural CDC HHS [CC999999] NR 78 TC 4 Z9 4 U1 1 U2 8 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1092-7875 EI 1573-6628 J9 MATERN CHILD HLTH J JI Matern. Child Health J. PD JAN PY 2015 VL 19 IS 1 BP 144 EP 154 DI 10.1007/s10995-014-1505-0 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY0OK UT WOS:000347295600018 PM 24825031 ER PT J AU Coker, TR Elliott, MN Schwebel, DC Windle, M Toomey, SL Tortolero, SR Hertz, MF Peskin, MF Schuster, MA AF Coker, Tumaini R. Elliott, Marc N. Schwebel, David C. Windle, Michael Toomey, Sara L. Tortolero, Susan R. Hertz, Marci F. Peskin, Melissa F. Schuster, Mark A. TI Media Violence Exposure and Physical Aggression in Fifth-Grade Children SO ACADEMIC PEDIATRICS LA English DT Article DE aggressive behavior; media; media violence; violent behavior ID MIDDLE SCHOOL-CHILDREN; VIDEO GAMES; PROSOCIAL BEHAVIOR; ADOLESCENTS; TELEVISION; HEALTH; ASSOCIATION; ADULTHOOD; EMPATHY AB OBJECTIVE: To examine the association of media violence exposure and physical aggression in fifth graders across 3 media types. METHODS: We analyzed data from a population-based, cross-sectional survey of 5,147 fifth graders and their parents in 3 US metropolitan areas. We used multivariable linear regression and report partial correlation coefficients to examine associations between children's exposure to violence in television/film, video games, and music (reported time spent consuming media and reported frequency of violent content: physical fighting, hurting, shooting, or killing) and the Problem Behavior Frequency Scale. RESULTS: Child-reported media violence exposure was associated with physical aggression after multivariable adjustment for sociodemographics, family and community violence, and child mental health symptoms (partial correlation coefficients: TV, 0.17; video games, 0.15; music, 0.14). This association was significant and independent for television, video games, and music violence exposure in a model including all 3 media types (partial correlation coefficients: TV, 0.11; video games, 0.09; music, 0.09). There was a significant positive interaction between media time and media violence for video games and music but not for television. Effect sizes for the association of media violence exposure and physical aggression were greater in magnitude than for most of the other examined variables. CONCLUSIONS: The association between physical aggression and media violence exposure is robust and persistent; the strength of this association of media violence may be at least as important as that of other factors with physical aggression in children, such as neighborhood violence, home violence, child mental health, and male gender. C1 [Coker, Tumaini R.] Univ Calif Los Angeles, David Geffen Sch Med, Mattel Childrens Hosp, Dept Pediat, Los Angeles, CA 90024 USA. [Coker, Tumaini R.; Elliott, Marc N.] RAND Corp, Santa Monica, CA USA. [Schwebel, David C.] Univ Alabama Birmingham, Dept Psychol, Birmingham, AL 35294 USA. [Windle, Michael] Emory Univ, Dept Behav Sci & Hlth Educ, Atlanta, GA 30322 USA. [Toomey, Sara L.; Schuster, Mark A.] Harvard Univ, Sch Med, Div Gen Pediat, Boston Childrens Hosp, Boston, MA USA. [Toomey, Sara L.; Schuster, Mark A.] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA. [Tortolero, Susan R.; Peskin, Melissa F.] Univ Texas Houston, Sch Publ Hlth, Ctr Hlth Promot & Prevent Res, Houston, TX USA. [Hertz, Marci F.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Coker, TR (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Mattel Childrens Hosp, RAND Ctr Adolescent Hlth Promot, 10833 Le Conte Ave,12-467 MDCC, Los Angeles, CA 90024 USA. EM tcoker@mednet.ucla.edu FU Centers for Disease Control and Prevention, Prevention Research Centers [CCU409679, CCU6-09653, CCU915773, U48DP000046, U48DP000057, U48DP000056, U19DP002663, U19DP002664, U19DP002665] FX The Healthy Passages Study was funded by the Centers for Disease Control and Prevention, Prevention Research Centers (CCU409679, CCU6-09653, CCU915773, U48DP000046, U48DP000057, U48DP000056, U19DP002663, U19DP002664, and U19DP002665). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. The funder was not involved in decisions regarding the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Marci Hertz is employed at the Centers for Disease Control and Prevention and had input into the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, and approval of the manuscript. NR 39 TC 1 Z9 2 U1 16 U2 106 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1876-2859 EI 1876-2867 J9 ACAD PEDIATR JI Acad. Pediatr. PD JAN-FEB PY 2015 VL 15 IS 1 BP 82 EP 88 DI 10.1016/j.acap.2014.09.008 PG 7 WC Pediatrics SC Pediatrics GA AY0BJ UT WOS:000347262600013 PM 25441652 ER PT J AU Tong, VT Althabe, F Aleman, A Johnson, CC Dietz, PM Berrueta, M Morello, P Colomar, M Buekens, P Sosnoff, CS Farr, SL Mazzoni, A Ciganda, A Becu, A Gonzalez, MGB Llambi, L Gibbons, L Smith, RA Belizan, JM AF Tong, Van T. Althabe, Fernando Aleman, Alicia Johnson, Carolyn C. Dietz, Patricia M. Berrueta, Mabel Morello, Paola Colomar, Mercedes Buekens, Pierre Sosnoff, Connie S. Farr, Sherry L. Mazzoni, Agustina Ciganda, Alvaro Becu, Ana Bittar Gonzalez, Maria G. Llambi, Laura Gibbons, Luz Smith, Ruben A. Belizan, Jose M. CA Prenatal Tobacco Cessation TI Accuracy of self-reported smoking cessation during pregnancy SO ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA LA English DT Article DE Smoking; reproductive health; pregnancy; cotinine; biochemical verification; Argentina; Uruguay ID TANDEM MASS-SPECTROMETRY; TOBACCO USE; WOMEN; SMOKERS; NONSMOKERS; ARGENTINA; EXPOSURE; COTININE; SERUM AB Evidence of bias of self-reported smoking cessation during pregnancy is reported in high-income countries but not elsewhere. We sought to evaluate self-reported smoking cessation during pregnancy using biochemical verification and to compare characteristics of women with and without biochemically confirmed cessation in Argentina and Uruguay. In a cross-sectional study from October 2011 to May 2012, women who attended one of 21 prenatal clinics and delivered at selected hospitals in Buenos Aires, Argentina and Montevideo, Uruguay, were surveyed about their smoking cessation during pregnancy. We tested saliva collected from women <12h after delivery for cotinine to evaluate self-reported smoking cessation during pregnancy. Overall, 10.0% (44/441) of women who self-reported smoking cessation during pregnancy had biochemical evidence of continued smoking. Women who reported quitting later in pregnancy had a higher percentage of nondisclosure (17.2%) than women who reported quitting when learning of their pregnancy (6.4%). C1 [Tong, Van T.; Dietz, Patricia M.; Farr, Sherry L.; Smith, Ruben A.] Ctr Dis Control & Prevent, Div Reprod Hlth, NCCDPHP, Atlanta, GA 30341 USA. [Althabe, Fernando; Berrueta, Mabel; Morello, Paola; Mazzoni, Agustina; Becu, Ana; Gibbons, Luz; Belizan, Jose M.] Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina. [Aleman, Alicia; Colomar, Mercedes; Ciganda, Alvaro] Montevideo Clin & Epidemiol Res Unit, Montevideo, Uruguay. [Johnson, Carolyn C.; Buekens, Pierre] Tulane Sch Publ Hlth & Trop Med, New Orleans, LA USA. [Sosnoff, Connie S.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Bittar Gonzalez, Maria G.; Llambi, Laura] Univ Republica, Fac Med, Montevideo, Uruguay. RP Tong, VT (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, NCCDPHP, 4770 Buford Hwy NE,MS-F74, Atlanta, GA 30341 USA. EM vtong@cdc.gov OI Belizan, Jose/0000-0002-8412-3010 FU Centers for Disease Control and Prevention [5U48DP001948-04 (SIP09-18)] FX The study was supported through Centers for Disease Control and Prevention cooperative agreement 5U48DP001948-04 (SIP09-18) to Tulane University. NR 14 TC 3 Z9 3 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0001-6349 EI 1600-0412 J9 ACTA OBSTET GYN SCAN JI Acta Obstet. Gynecol. Scand. PD JAN PY 2015 VL 94 IS 1 BP 106 EP 111 DI 10.1111/aogs.12532 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AX1JS UT WOS:000346704100018 PM 25350478 ER PT J AU Martorell, R Ascencio, M Tacsan, L Alfaro, T Young, MF Addo, OY Dary, O Flores-Ayala, R AF Martorell, Reynaldo Ascencio, Melany Tacsan, Luis Alfaro, Thelma Young, Melissa F. Addo, O. Yaw Dary, Omar Flores-Ayala, Rafael TI Effectiveness evaluation of the food fortification program of Costa Rica: impact on anemia prevalence and hemoglobin concentrations in women and children SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE anemia; Costa Rica; food fortification; hemoglobin; women and children ID WHEAT-FLOUR FORTIFICATION; FORTIFIED MILK; LOW-INCOME; IRON; IMPLEMENTATION; OUTCOMES; SCALE AB Background: Food fortification is one approach for addressing anemia, but information on program effectiveness is limited. Objective: We evaluated the impact of Costa Rica's fortification program on anemia in women aged 15-45 y and children aged 1-7 y. Design: Reduced iron, an ineffective fortificant, was replaced by ferrous fumarate in wheat flour in 2002, and ferrous bisglycinate was added to maize flour in 1999 and to liquid and powdered milk in 2001. We used a one-group pretest-posttest design and national survey data from 1996 (baseline; 910 women, 965 children) and 2008-2009 (endline; 863 women, 403 children) to assess changes in iron deficiency (children only) and anemia. Data were also available for sentinel sites (1 urban, 1 rural) for 1999-2000 (405 women, 404 children) and 2008-2009 (474 women, 195 children), including 24-h recall data in children. Monitoring of fortification levels was routine. Results: Foods were fortified as mandated. Fortification provided about one-half the estimated average requirement for iron in children, mostly and equally through wheat flour and mine. Anemia was reduced in children and women in national and sentinel site comparisons. At the national level, anemia declined in children from 19.3% (95% CI: 16.8%, 21.8%) to 4.0% (95% CI: 2.1%, 5.9%) and in women from 18.4% (95% CI: 15.8%, 20.9%) to 10.2% (95% CI: 8.2%, 12.2%). In children, iron deficiency declined from 26.9% (95% CI: 21.1%, 32.7%) to 6.8% (95% CI: 4.2%, 9.3%), and iron deficiency anemia, which was 6.2% (95% CI: 3.0%, 9.3%) at baseline, could no longer be detected at the endline. Conclusions: A plausible impact pathway suggests that fortification improved iron status and reduced anemia. Although unlikely in the Costa Rican context, other explanations cannot be excluded in a pre/post comparison. C1 [Martorell, Reynaldo; Young, Melissa F.; Addo, O. Yaw; Flores-Ayala, Rafael] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. [Ascencio, Melany; Tacsan, Luis] Minist Salud, Direcc Desarrollo Cient & Tecnol Salud, San Jose, Costa Rica. [Alfaro, Thelma] Inst Costarricense Invest & Ensenanza Nutr & Salu, Ctr Nacl Referencia Bromatol, Cartago, Costa Rica. [Dary, Omar] US Agcy Int Dev, Div Nutr, Off Hlth Infect Dis & Nutr, Bur Global Hlth, Washington, DC 20523 USA. [Flores-Ayala, Rafael] US CDC, IMMPaCt Program, Nutr Branch, Div Nutr Phys Act & Obes, Atlanta, GA USA. RP Martorell, R (reprint author), Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, 1599 Clifton Rd, Atlanta, GA 30322 USA. EM rmart77@emory.edu OI Addo, O.Yaw/0000-0003-1269-759X FU Micronutrient Initiative, Ottawa, Canada FX Supported by The Micronutrient Initiative, Ottawa, Canada. NR 31 TC 10 Z9 10 U1 2 U2 15 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD JAN PY 2015 VL 101 IS 1 BP 210 EP 217 DI 10.3945/ajcn.114.097709 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AX4ID UT WOS:000346895700024 PM 25527765 ER PT J AU Wong, LY Uddin, MS Turner, W Ragin, AD Deanvent, S AF Wong, Lee-Yang Uddin, Mohammed S. Turner, Wayman Ragin, Angela D. Deanvent, Steve TI Serum PCB concentrations in residents of Calcasieu and Lafayette Parishes, Louisiana with comparison to the US population SO CHEMOSPHERE LA English DT Article DE Environmental health; Polychlorinated biphenyls; Serum; Population-based cross-sectional study ID CHEMICALS; DIET; AGE AB In 2002, a cross-sectional study designed to compare the serum dioxin toxic equivalent concentrations (TEQ) of a population-based sample of Calcasieu Parish, Louisiana residents, to Lafayette Parish was conducted. The mono-ortho polychlorinated biphenyls (PCBs) were measured in order to calculate the TEQ. We compared the sum of lipid adjusted serum concentrations of 27 PCB congeners (total PCBs) in residents of these two parishes and also by their demographic characteristics. The geometric means (GM) [standard errors (SE)] of the concentrations (ng g(-1) lipids) of total PCBs in participants from Calcasieu Parish and Lafayette Parish were 154 (11.8) and 168.6 (20.8) (T-test p = 0.54), respectively. Various percentiles of the distribution of serum total PCB concentrations were similar in the two parishes. After adjusting by age and race in the ANCOVA regression model, the adjusted GM for the lipid adjusted total PCBs was statistically higher in the residents in Lafayette than in Calcasieu Parish regardless of age or race (P = 0.007). The adjusted GM of lipid adjusted total PCBs for African Americans was significantly higher than for Whites (p < 0.001). Serum total PCB levels in residents of both parishes increased linearly with age (P < 0.001). The congener profiles were similar in residents of both parishes. We also compared the GMs of a sum of 8 PCBs in Calcasieu and Lafayette Parish residents to those from a representative sample of the U.S. general population in 2001-2002 and they were not significantly different between parishes or between the parish data and the U.S. general population. Published by Elsevier Ltd. C1 [Wong, Lee-Yang; Turner, Wayman] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Uddin, Mohammed S.; Ragin, Angela D.] Agcy Toxic Subst & Dis Registry, Atlanta, GA 30341 USA. [Deanvent, Steve] Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Atlanta, GA 30341 USA. RP Wong, LY (reprint author), Mailstop F17,CDC,4770 Buford Highway, Atlanta, GA 30341 USA. EM lyw8@cdc.gov NR 15 TC 0 Z9 0 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 EI 1879-1298 J9 CHEMOSPHERE JI Chemosphere PD JAN PY 2015 VL 118 BP 156 EP 162 DI 10.1016/j.chemosphere.2014.07.073 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA AX5GC UT WOS:000346953700022 PM 25163413 ER PT J AU Haynes, CA de Jesus, VR AF Haynes, Christopher A. de Jesus, Vctor R. TI The stability of hexacosanoyl lysophosphatidylcholine in dried-blood spot quality control materials for X-linked adrenoleukodystrophy newborn screening SO CLINICAL BIOCHEMISTRY LA English DT Article DE Tandem mass spectrometry; Dried-blood spot; X-linked adrenoleukodystrophy; Newborn screening; Lysophosphatidylcholine ID TANDEM MASS-SPECTROMETRY; MS/MS; VALIDATION AB Objectives: Newborn screening for X-linked adrenoleukodystrophy utilizes tandem mass spectrometry to analyze dried-blood spot specimens. Quality control materials (dried-blood spots enriched with hexacosanoyl lysophosphatidylcholine) were prepared and stored at different temperatures for up to 518 days to evaluate the stability of this biomarker for X-linked adrenoleukodystrophy. Design and methods: Dried-blood spot storage included desiccant (45, 171, and 518 days) or omitted desiccant (53 days at N90% relative humidity). Specimens were stored for 171 and 518 days at -20 degrees C, 4 degrees C, ambient temperature, and 37 degrees C. Each weekday for 45 days, a bag of specimens stored at 4 degrees C was warmed to ambient temperature and one specimen was removed for storage at -80 degrees C. Specimens were analyzed by high-performance liquid-chromatography electrospray ionization tandem mass spectrometry and data was plotted as concentration (micromoles per liter) vs. time. Linear regression provided slope and y-intercept values for each storage condition. Results: Small slope values (0.01 or less) and y-intercept values close to the enrichment indicated less than 11% loss of hexacosanoyl lysophosphatidylcholine under all storage conditions tested. Conclusions: Quality control materials for X-linked adrenoleukodystrophy are stable for at least 1 year when stored with desiccant. The Canadian Society of Clinical Chemists. Published by Elsevier Inc. C1 [Haynes, Christopher A.; de Jesus, Vctor R.] Ctr Dis Control & Prevent, Newborn Screening & Mol Biol Branch, Atlanta, GA 30341 USA. RP Haynes, CA (reprint author), 4770 Buford Hwy NE, Atlanta, GA 30341 USA. EM cph7@cdc.gov FU Intramural CDC HHS [CC999999] NR 11 TC 4 Z9 4 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0009-9120 EI 1873-2933 J9 CLIN BIOCHEM JI Clin. Biochem. PD JAN PY 2015 VL 48 IS 1-2 BP 8 EP 10 DI 10.1016/j.clinbiochem.2014.10.001 PG 3 WC Medical Laboratory Technology SC Medical Laboratory Technology GA AX3QC UT WOS:000346852900003 PM 25307302 ER PT J AU Nichols, EK Khatib, IMD Aburto, NJ Serdula, MK Scanlon, KS Wirth, JP Sullivan, KM AF Nichols, E. K. Khatib, I. M. D. Aburto, N. J. Serdula, M. K. Scanlon, K. S. Wirth, J. P. Sullivan, K. M. TI Vitamin D status and associated factors of deficiency among Jordanian children of preschool age SO EUROPEAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID NUTRITIONAL RICKETS; HYPOVITAMINOSIS-D; REPRODUCTIVE AGE; PREVALENCE; INFANTS; WOMEN; DETERMINANTS; HEALTHY; OBESITY AB BACKGROUND/OBJECTIVES: Vitamin D deficiency in children remains a global concern. Although literature exists on the vitamin D status and its risk factors among children in the Middle East, findings have yielded mixed results, and large, representative community studies are lacking. SUBJECTS/METHODS: In a nationally representative survey of 1077 Jordanian children of preschool age (12-59 months) in Spring 2010, we measured 25(OH)D-3 concentrations by liquid chromatography-tandem mass spectrometry and calculated prevalence ratios for deficiency associated with various factors. RESULTS: Results showed 19.8% (95% confidence interval (Cl): 16.4-23.3%) deficiency ( < 12 ng/ml) and 56.5% (95% Cl: 52.0-61.0%) insufficiency ( < 20 ng/ml). In adjusted models, prevalence of deficiency was higher for females compared with males (prevalence ratio (PR) = 1.74, 95% Cl: 1.22-2.47, P=0.002) and lower for children 24-35 months of age (PR=0.64, 95% Cl: 0.44-0.92, P=0.018) compared with children 12-23 months of age. In rural areas, there was no difference in prevalence of vitamin D deficiency between those whose mothers had/did not have vitamin D deficiency (P=0.312); however, in urban areas, prevalence of vitamin D deficiency was 3.18 times greater among those whose mothers were vitamin D deficient compared with those whose mothers were not deficient (P=0.000). CONCLUSIONS: Vitamin D deficiency and insufficiency pose significant public health problems in Jordanian children with female children disproportionately affected. Strong associations between vitamin D status in children and urban residency and maternal vitamin D status suggest that the behaviors related to sun exposure in urban mothers likely also affect the sun exposure and thus vitamin D status of their children. C1 [Nichols, E. K.] Publ Hlth Serv, Epidem Intelligence Serv, Div Nutr Phys Act & Obes, Ctr Dis Control & Prevent, Atlanta, GA USA. [Khatib, I. M. D.] Jordan Univ Sci & Technol, Fac Med, Dept Publ Hlth, Irbid, Jordan. [Aburto, N. J.; Serdula, M. K.; Scanlon, K. S.; Sullivan, K. M.] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA USA. [Wirth, J. P.] GroundWork LLC, CH-1299 Crans Pres Celigny, Nyon, Switzerland. [Wirth, J. P.] Global Alliance Improved Nutr, Geneva, Switzerland. [Sullivan, K. M.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA. RP Nichols, EK (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd,Rm 2423,MS P08, Hyattsville, MD 20782 USA. EM igd1@cdc.gov FU Global Alliance for Improved Nutrition (GAIN); Government of Jordan Ministry of Health; GAIN; CDC FX The current survey was funded through a grant agreement between the Global Alliance for Improved Nutrition (GAIN) and the Government of Jordan Ministry of Health, and through a Memorandum of Understanding between GAIN and CDC. We especially acknowledge Usha Manadava (deceased) and Rosemary Schleicher for their laboratory support, and Faruq Zghol, Iyad Hamzeh, and Ashraf Mettlaq for helping in the vitamin D laboratory analyses. We would also like to thank Hanan Masa'd, Rawhieh Barham, Aktham Haddadin, Tarek Al-Sanouri, Mohammed Tarawaneh, Bassam Hijawi, Nadera Al-Shareff, Ruba Nabulsi and the many individuals who assisted in the completion of the micronutrient survey. NR 37 TC 2 Z9 2 U1 1 U2 7 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0954-3007 EI 1476-5640 J9 EUR J CLIN NUTR JI Eur. J. Clin. Nutr. PD JAN PY 2015 VL 69 IS 1 BP 90 EP 95 DI 10.1038/ejcn.2014.142 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AY0EY UT WOS:000347271600015 PM 25117992 ER PT J AU Zhang, CL Sundaram, R Maisog, J Calafat, AM Barr, DB Louis, GMB AF Zhang, Cuilin Sundaram, Rajeshwari Maisog, Jose Calafat, Antonia M. Barr, Dana Boyd Louis, Germaine M. Buck TI A prospective study of prepregnancy serum concentrations of perfluorochemicals and the risk of gestational diabetes SO FERTILITY AND STERILITY LA English DT Article DE Perfluorochemicals (PFCs); perfluorooctanoic acid (PFOA); gestational diabetes; pregnancy ID FLUOROCHEMICAL PRODUCTION WORKERS; PERFLUOROOCTANOIC ACID; AMMONIUM PERFLUOROOCTANOATE; LIVER-ENZYMES; EXPOSURE; PFOA; POPULATION; MELLITUS; COHORT; LIFE AB Objective: To examine preconception serum concentrations of perfluorooctanoic acid (PFOA) and six other PFCs in relation to gestational diabetes (GDM) risk. Design: Prospective cohort with longitudinal follow-up. Setting: Not applicable. Patient(s): Among 501 women recruited upon discontinuing contraception for the purpose of becoming pregnant, 258 (51%) became pregnant and were eligible for the study, of which 28 (11%) reported having physician-diagnosed GDM during follow-up. Intervention(s): None. Main Outcome Measure(s): The odds ratios (ORs) and 95% confidence intervals (CIs) of GDM associated with each standard deviation (SD) increment of preconception serum PFOA concentration (ng/mL, log-transformed) and six other PFCs were estimated with the use of logistic regression after adjusting for age, prepregnancy body mass index, smoking, and parity conditional on gravidity. Result(s): Preconception geometric mean (95% CI) PFOA concentrations (in ng/mL) were higher for women with than without GDM (3.94 [3.15-4.93] vs. 3.07 [2.83-3.12], respectively). Each SD increment in PFOA was associated with a 1.87-fold increased GDM risk (adjusted OR 1.86 [95% CI 1.14-3.02]). A slightly increased risk associated with each SD increment for the six other PFCs was observed as well (all ORs > 1.0, range 1.06-1.27), although the associations were not statistically significant. Conclusion(s): Our findings suggested that higher environmentally relevant concentrations of PFOA were significantly associated with an increased risk of GDM. If corroborated, these findings may be suggestive of a possible environmental etiology for GDM. (C) 2015 by American Society for Reproductive Medicine. C1 [Zhang, Cuilin; Sundaram, Rajeshwari; Maisog, Jose; Louis, Germaine M. Buck] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Intramural Populat Hlth Res, Rockville, MD 20852 USA. [Calafat, Antonia M.] Ctr Dis Control & Prevent, Div Sci Lab, Atlanta, GA USA. [Barr, Dana Boyd] Emory Univ, Dept Occupat & Environm Hlth, Atlanta, GA 30322 USA. [Barr, Dana Boyd] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. RP Zhang, CL (reprint author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, NIH, 6100 Execut Blvd, Rockville, MD 20852 USA. EM zhangcu@mail.nih.gov OI Sundaram, Rajeshwari/0000-0002-6918-5002; Buck Louis, Germaine/0000-0002-1774-4490 FU Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development [N01-HD-3-3355, N01-HD-3-3356, NOH-HD-3-3358] FX Supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (contracts N01-HD-3-3355, N01-HD-3-3356, and NOH-HD-3-3358). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 35 TC 7 Z9 7 U1 1 U2 13 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 EI 1556-5653 J9 FERTIL STERIL JI Fertil. Steril. PD JAN PY 2015 VL 103 IS 1 BP 184 EP 189 DI 10.1016/j.fertnstert.2014.10.001 PG 6 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA AX4OK UT WOS:000346911400033 PM 25450302 ER PT J AU Carpenter, SL Soucie, JM Presley, RJ Ragni, MV Wicklund, BM Silvey, M Davidson, H AF Carpenter, S. L. Soucie, J. M. Presley, R. J. Ragni, M. V. Wicklund, B. M. Silvey, M. Davidson, H. CA Hemophilia Treatment Ctr Network TI Hepatitis B vaccination is effective by subcutaneous route in children with bleeding disorders: a universal data collection database analysis SO HAEMOPHILIA LA English DT Article DE bleeding disorders; haemophilia; hepatitis B; immunizations; intramuscular; subcutaneous; UDC ID CONGENITAL COAGULATION DISORDERS; A VACCINE; HEMOPHILIACS; IMMUNOGENICITY; SAFETY; IMMUNIZATION; INJECTION; VIRUS AB Subcutaneous (SQ) vs. intramuscular (IM) vaccination may cause fewer injection site complications in children with bleeding disorders, but little is known about comparative immunogenicity. To compare immunogenicity of hepatitis B virus (HBV) vaccination administered SQ or IM to individuals <2 years old with bleeding disorders, we performed a retrospective analysis of HBV surface antibody titres among patients enrolled in the universal data collection database who had received three doses of HBV vaccine solely by one route (SQ or IM). Data reviewed were from an initial visit before 24 months of age, until time of hepatitis antibody titre testing. The SQ and IM study groups did not differ in demographics, haemophilia type or severity or bleeding history. The mean age at the time of HBV surface antibody (anti-HBs) testing was 56.9 +/- 20.3 months. Eighty-five of 92 subjects (92.4%) who received vaccine SQ developed a positive antibody titre (>12 IU/L), compared to 101/114 (88.6%) who received IM (P = 0.30). There was no statistically significant difference in distribution of titre values. The average age of the subjects at time of testing was 53 +/- 20 months in the SQ group vs. 60+/-20 months in the IM group (P = 0.02). The average time between the last dose of vaccine and anti-HBs testing was 47.6+/-18.5 months among SQ vaccinated subjects vs. 51.6+/-20.5 months in the IM group (P = 0.2). Immunogenicity to hepatitis B vaccination by the SQ and IM routes is similar. C1 [Carpenter, S. L.; Wicklund, B. M.; Silvey, M.] Childrens Mercy Hosp, Dept Pediat, Kansas City, MO 64108 USA. [Soucie, J. M.; Presley, R. J.] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. [Ragni, M. V.] Univ Pittsburgh, Dept Med, Med Ctr, Pittsburgh, PA USA. [Davidson, H.] Phoenix Childrens Hosp, Dept Pediat, Phoenix, AZ USA. RP Carpenter, SL (reprint author), Childrens Mercy Hosp, 2401 Gillham Rd, Kansas City, MO 64108 USA. EM slcarpenter@cmh.edu RI Kerlin, Bryce/E-3369-2011 OI Kerlin, Bryce/0000-0002-1756-8271 FU Centers for Disease Control and Prevention; Grant/Cooperative Agreement Prevention of Bleeding Disorder Complications through Regional Hemophilia Treatment Centers FX The authors would like to acknowledge the support of the Centers for Disease Control and Prevention for their help in designing and completing this research and for the use of the UDC data. The analysis and writing represented in this publication was supported by the Grant/Cooperative Agreement Prevention of Bleeding Disorder Complications through Regional Hemophilia Treatment Centers. We would also like to thank the patients, staffs and physicians of the Hemophilia Treatment Centers who contribute to the UDC database, whose efforts were critical to the completion of this work. NR 22 TC 1 Z9 1 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1351-8216 EI 1365-2516 J9 HAEMOPHILIA JI Haemophilia PD JAN PY 2015 VL 21 IS 1 BP E39 EP E43 DI 10.1111/hae.12569 PG 5 WC Hematology SC Hematology GA AX5RU UT WOS:000346985600005 PM 25381731 ER PT J AU Sjolund-Karlsson, M Howie, R Rickert, R Newton, A Gonzalez-Aviles, G Crump, JA AF Sjoelund-Karlsson, Maria Howie, Rebecca Rickert, Regan Newton, Anna Gonzalez-Aviles, Gladys Crump, John A. TI Plasmid-mediated quinolone resistance in isolates of Salmonella enterica serotype Typhi, USA SO INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS LA English DT Letter ID UNITED-STATES C1 [Sjoelund-Karlsson, Maria; Rickert, Regan; Newton, Anna; Gonzalez-Aviles, Gladys; Crump, John A.] US Ctr Dis Control & Prevent, Div Foodbome Waterborne & Environm Dis, Atlanta, GA 30329 USA. [Howie, Rebecca] IHRC Inc, Atlanta, GA USA. RP Sjolund-Karlsson, M (reprint author), US Ctr Dis Control & Prevent, Natl Antimicrobial Resistance Monitoring Syst, OID NCEZID DFWED EDLB, 1600 Clifton Rd,Mail Stop G29, Atlanta, GA 30329 USA. EM fwt4@cdc.gov NR 6 TC 3 Z9 3 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-8579 EI 1872-7913 J9 INT J ANTIMICROB AG JI Int. J. Antimicrob. Agents PD JAN PY 2015 VL 45 IS 1 BP 88 EP 90 PG 4 WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy GA AX7OU UT WOS:000347105800017 PM 25465527 ER PT J AU Hirsch-Moverman, Y Shrestha-Kuwahara, R Bethel, J Blumberg, HM Venkatappa, TK Horsburgh, CR Colson, PW AF Hirsch-Moverman, Y. Shrestha-Kuwahara, R. Bethel, J. Blumberg, H. M. Venkatappa, T. K. Horsburgh, C. R., Jr. Colson, P. W. CA TB Epidemiologic Studies Consortiu TI Latent tuberculous infection in the United States and Canada: who completes treatment and why? SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE LA English DT Article DE latent tuberculous infection; adherence; treatment; prospective cohort ID ACCEPTANCE AB OBJECTIVES: To assess latent tuberculous infection (LTBI) treatment completion rates in a large prospective US/Canada multisite cohort and identify associated risk factors. METHODS: This prospective cohort study assessed factors associated with LTBI treatment completion through interviews with persons who initiated treatment at 12 sites. Interviews were conducted at treatment initiation and completion/cessation. Participants received usual care according to each clinic's procedure. Muhivariable models were constructed based on step-wise assessment of potential predictors and interactions. RESULTS: Of 1515 participants initiating LTBI treatment, 1323 had information available on treatment completion; 617 (46.6%) completed treatment. Baseline predictors of completion included male sex, foreign birth, not thinking it would be a problem to take anti-tuberculosis medication, and having health insurance. Participants in stable housing who received monthly appointment reminders were more likely to complete treatment than those without stable housing or without monthly reminders. End-of-treatment predictors of non-completion included severe symptoms and the inconvenience of clinic/pharmacy schedules, barriers to care and changes of residence. Common reasons for treatment non-completion were patient concerns about tolerability/toxicity, appointment conflicts, low prioritization of TB, and forgetfulness. CONCLUSIONS: Less than half of treatment initiators completed treatment in our multisite study. Addressing tangible issues such as not having health insurance, toxicity concerns, and clinic accessibility could help to improve treatment completion rates. C1 [Hirsch-Moverman, Y.; Colson, P. W.] Columbia Univ, Mailman Sch Publ Hlth, ICAP, Charles P Felton Natl TB Ctr, New York, NY USA. [Shrestha-Kuwahara, R.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Bethel, J.] Westat Corp, Rockville, MD USA. [Blumberg, H. M.] Emory Univ, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA. [Venkatappa, T. K.] Hawaii Dept Hlth, Wailuku, HI USA. [Horsburgh, C. R., Jr.] Boston Univ, Sch Publ Hlth, Boston, MA USA. RP Hirsch-Moverman, Y (reprint author), Columbia Univ, Mailman Sch Publ Hlth, ICAP, Suite A,1st Floor,215 W 125th St, New York, NY 10027 USA. EM yh154@columbia.edu; pwc2@columbia.edu FU CDC FX This work was supported by the CDC. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC. NR 15 TC 13 Z9 13 U1 0 U2 6 PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) PI PARIS PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE SN 1027-3719 EI 1815-7920 J9 INT J TUBERC LUNG D JI Int. J. Tuberc. Lung Dis. PD JAN PY 2015 VL 19 IS 1 BP 31 EP 38 DI 10.5588/ijtld.14.0373 PG 8 WC Infectious Diseases; Respiratory System SC Infectious Diseases; Respiratory System GA AX4HG UT WOS:000346893500007 PM 25519787 ER PT J AU Yuen, CM Krapivina, TM Kazennyy, BY Kiryanova, EV Aksenova, VA Gordina, A Finlay, AM Cegielski, JP AF Yuen, C. M. Krapivina, T. M. Kazennyy, B. Y. Kiryanova, E. V. Aksenova, V. A. Gordina, A. Finlay, A. M. Cegielski, J. P. TI Annual risk of tuberculous infection measured using serial skin testing, Orel Oblast, Russia, 1991-2005 SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE LA English DT Article DE tuberculous infection; tuberculin test; Russia ID CALMETTE-GUERIN VACCINATION; CHILDREN AB OBJECTIVE: To compare trends in direct annual risk of tuberculous infection (ARTI) during 1991-2005 in relation to tuberculosis (TB) incidence and to indirect estimates of ARTI derived from the prevalence of tuberculin skin test (TST) positivity in schoolchildren in Orel Oblast, Russia. DESIGN: In 2005, we abstracted annual TST results and vaccination histories from a representative sample of schoolchildren in Orel Oblast, Russia, where bacille Calmette-Guerin (BCG) vaccination and annual TST of children are nearly universal. We calculated direct ARTI based on the percentage of children tested with TST conversions each year, excluding conversions following BCG vaccination. RESULTS: We analysed records from 13 206 children, with a median of 10 recorded TST results per child. The ARTI increased from 0.2% in 1991 to 1.6% in 2000, paralleling trends in TB incidence. Similar results were observed when the ARTI was estimated based on prevalence of infection among children aged 3-5 years using a 12 mm cut-off to define TST positivity. Results differed substantially when 10 or 15 mm cut-offs were used or when prevalence was determined among children aged 6-8 years. CONCLUSION: ARTI measured through TST conversion increased as TB incidence increased in Orel Oblast. ARTI measured through serial TSTs can thus provide an indicator of changing trends in TB incidence. C1 [Yuen, C. M.; Finlay, A. M.; Cegielski, J. P.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA. [Krapivina, T. M.; Kazennyy, B. Y.; Kiryanova, E. V.] Orel Oblast TB Dispensary, Oryol, Russia. [Aksenova, V. A.; Gordina, A.] IM Sechenov Moscow Med Acad, Res Inst Phtisiopulmonol, Moscow, Russia. RP Cegielski, JP (reprint author), Ctr Dis Control & Prevent, 1600 Clifton Rd NE,MS E-10, Atlanta, GA 30333 USA. EM pcegielski@cdc.gov NR 14 TC 0 Z9 0 U1 0 U2 0 PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) PI PARIS PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE SN 1027-3719 EI 1815-7920 J9 INT J TUBERC LUNG D JI Int. J. Tuberc. Lung Dis. PD JAN PY 2015 VL 19 IS 1 BP 39 EP 43 DI 10.5588/ijtld.14.0445 PG 5 WC Infectious Diseases; Respiratory System SC Infectious Diseases; Respiratory System GA AX4HG UT WOS:000346893500008 PM 25519788 ER PT J AU Volkmann, T Moonan, PK Miramontes, R Oeltmann, JE AF Volkmann, T. Moonan, P. K. Miramontes, R. Oeltmann, J. E. TI Tuberculosis and excess alcohol use in the United States, 1997-2012 SO INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE LA English DT Article DE substance use; Mycobacterium tuberculosis; directly observed therapy; sputum culture; culture conversion ID NEW-YORK-CITY; SUBSTANCE-ABUSE; RISK-FACTORS; SURVEILLANCE; ASSOCIATION; CONSUMPTION; OUTBREAK; DISEASES; SMOKING; RUSSIA AB BACKGROUND: Excess alcohol use among tuberculosis (TB) patients complicates TB control strategies. OBJECTIVES: To characterize the role of excess alcohol use in TB control, we describe the epidemiology of excess alcohol use and TB in the United States among those aged 15 years. DESIGN: Using data reported to the National Tuberculosis Surveillance System, 1997-2012, we examined associations between excess alcohol use and TB treatment outcomes and markers for increased transmission (involvement in a local genotype cluster of cases) using multivariate logistic regression. We used Cox proportional hazards regression analysis to examine the relationship between excess alcohol use and the rate of conversion from positive to negative in sputum culture results. RESULTS: Excess alcohol use was documented for 31 207 (15.1%) of 207 307 patients. Prevalence of excess alcohol use was greater among male patients (20.6%) and US-born patients (24.6%). Excess alcohol use was alsociated with a positive sputum smear result (aOR 1.23, 95%CI 1.18-1.28) and death during treatment (vs. completion of treatment) (aOR 1.16, 95%CI 1.10-1.22). The rate of culture conversion was higher among patients without excess alcohol use (adjusted hazard ratio 1.20, 95%CI 1.18-1.23). CONCLUSIONS: Excess alcohol use was common among patients with TB, and was associated with TB transmission, lower rates of sputum culture conversion, and greater mortality. C1 [Volkmann, T.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Div TB Eliminat, Atlanta, GA 30329 USA. [Moonan, P. K.; Miramontes, R.; Oeltmann, J. E.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30329 USA. RP Volkmann, T (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, MS E-10,1600 Clifton Rd NE, Atlanta, GA 30329 USA. EM xdh4@cdc.gov OI Moonan, Patrick/0000-0002-3550-2065; Miramontes, Roque/0000-0001-9535-460X FU Intramural CDC HHS [CC999999] NR 49 TC 3 Z9 3 U1 0 U2 4 PU INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) PI PARIS PA 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE SN 1027-3719 EI 1815-7920 J9 INT J TUBERC LUNG D JI Int. J. Tuberc. Lung Dis. PD JAN PY 2015 VL 19 IS 1 BP 111 EP 119 DI 10.5588/ijtld.14.0516 PG 9 WC Infectious Diseases; Respiratory System SC Infectious Diseases; Respiratory System GA AX4HG UT WOS:000346893500020 PM 25519800 ER PT J AU Cox, DJ Davis, MT Cox, BS Burket, RC Merkel, RL Mikami, AY Ford, D AF Cox, Daniel J. Davis, Margaret Taylor Cox, Brian S. Burket, Roger C. Merkel, Richard L. Mikami, Amori Yee Ford, Derek TI Quantifying the Relationship Between Perceived Consequences of ADHD Medication and Its Usage SO JOURNAL OF ATTENTION DISORDERS LA English DT Article DE ADHD; medication; compliance; adherence; side effects ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; STIMULANT TREATMENT; ADHERENCE-SCALE; HEART-FAILURE; CHILDREN; BOYS AB Objective: To address a major barrier of medication noncompliance for individuals with ADHD, the authors present the ADHD Medication Attitude Scale (AMAS) with initial psychometric analyses and discriminant validity data. Method: The AMAS was posted on ADHD websites, along with questions about demographics and medication usage over a 6-month period. A total of 356 ADHD respondents qualified for data analysis (160 males, 196 females, mean age = 18.58, years range = 13-62 years, SD = 6.07). Results: Factor analysis revealed two factors: one indicating positive and the other indicating negative attitude toward medication. The final refined 22-item scale demonstrated good reliability ( =.83). More positive and less negative attitude factor scores, as well as age (older than 19 years), independently predicted respondents' self-report of taking medication, (2) (1, N = 248) = 38.95, p < .001. Conclusion: The AMAS is a psychometrically sound means of assessing attitudes toward ADHD medication, which significantly relate to self-reported medication usage. C1 [Cox, Daniel J.] Univ Virginia Hlth Syst, Dept Psychiat & Neurobehav Sci, Charlottesville, VA 22908 USA. [Davis, Margaret Taylor] Auburn Univ, Auburn, AL 36849 USA. [Cox, Brian S.] Texas Transportat Inst, College Stn, TX USA. [Burket, Roger C.; Merkel, Richard L.] Univ Virginia Hlth Syst, Charlottesville, VA 22908 USA. [Mikami, Amori Yee] Univ Virginia, Charlottesville, VA USA. [Ford, Derek] Ctr Dis Control, Atlanta, GA 30333 USA. RP Cox, DJ (reprint author), Univ Virginia Hlth Syst, Dept Psychiat & Neurobehav Sci, Charlottesville, VA 22908 USA. EM djc4f@virginia.edu FU Shire Pharmaceuticals FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by a grant from Shire Pharmaceuticals. NR 25 TC 0 Z9 0 U1 1 U2 7 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1087-0547 EI 1557-1246 J9 J ATTEN DISORD JI J. Atten. Disord. PD JAN PY 2015 VL 19 IS 1 BP 78 EP 83 DI 10.1177/1087054712452913 PG 6 WC Psychology, Developmental; Psychiatry SC Psychology; Psychiatry GA AX0PP UT WOS:000346654500010 PM 22912505 ER PT J AU Zehnbauer, BA AF Zehnbauer, Barbara A. TI Continuing Excellence SO JOURNAL OF MOLECULAR DIAGNOSTICS LA English DT Editorial Material C1 Ctr Dis Control & Prevent, Div Lab Programs Stand & Serv, Atlanta, GA 30333 USA. RP Zehnbauer, BA (reprint author), Ctr Dis Control & Prevent, Div Lab Programs Stand & Serv, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1525-1578 EI 1943-7811 J9 J MOL DIAGN JI J. Mol. Diagn. PD JAN PY 2015 VL 17 IS 1 BP 1 EP 1 DI 10.1016/j.jmoldx.2014.11.001 PG 1 WC Pathology SC Pathology GA AX8EM UT WOS:000347143100001 PM 25528185 ER PT J AU McAfee, T Babb, S McNabb, S Fiore, MC AF McAfee, Tim Babb, Stephen McNabb, Simon Fiore, Michael C. TI Helping Smokers Quit - Opportunities Created by the Affordable Care Act SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material ID TOBACCO-DEPENDENCE TREATMENT; MEDICAID COVERAGE; IMPACT C1 [McAfee, Tim; Babb, Stephen; McNabb, Simon] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30333 USA. [Fiore, Michael C.] Univ Wisconsin, Sch Med & Publ Hlth, Ctr Tobacco Res & Intervent, Madison, WI 53706 USA. RP McAfee, T (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30333 USA. FU NCI NIH HHS [P01 CA180945] NR 5 TC 19 Z9 19 U1 0 U2 6 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JAN 1 PY 2015 VL 372 IS 1 BP 5 EP 7 DI 10.1056/NEJMp1411437 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AX7MU UT WOS:000347100800003 PM 25409263 ER PT J AU Creanga, AA Berg, CJ Syverson, C Seed, K Bruce, FC Callaghan, WM AF Creanga, Andreea A. Berg, Cynthia J. Syverson, Carla Seed, Kristi Bruce, F. Carol Callaghan, William M. TI Pregnancy-Related Mortality in the United States, 2006-2010 SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID SEVERE OBSTETRIC MORBIDITY; WOMEN; HOSPITALIZATIONS; INFLUENZA; DELIVERY; TRENDS AB OBJECTIVE: To update national population-level pregnancy-related mortality estimates and examine characteristics and causes of pregnancy-related deaths in the United States during 2006-2010. METHODS: We used data from the Pregnancy Mortality Surveillance System and calculated pregnancy-related mortality ratios by year and age group for four race-ethnicity groups: non-Hispanic white, non-Hispanic black, Hispanic, and other. We examined causes of pregnancy-related deaths by pregnancy outcome during 2006-2010 and compared causes of pregnancy-related deaths since 1987. RESULTS: The 2006-2010 pregnancy-related mortality ratio was 16.0 deaths per 100,000 live births (20,959,533 total live births). Specific race-ethnicity pregnancy-related mortality ratios were 12.0, 38.9, 11.7, and 14.2 deaths per 100,000 live births for non-Hispanic white, non-Hispanic black, Hispanic, and other race women, respectively. Pregnancy-related mortality ratios increased with maternal age for all women and within all age groups, non-Hispanic black women had the highest risk of dying from pregnancy complications. Over time, the contribution to pregnancy-related deaths of hemorrhage, hypertensive disorders of pregnancy, embolism, and anesthesia complications continued to decline, whereas the contribution of cardiovascular conditions and infection increased. Seven of 10 categories of causes of death each contributed from 9.4% to 14.6% of all 2006-2010 pregnancy-related deaths; cardiovascular conditions ranked first. CONCLUSION: Relative to previous years, during 2006-2010, the U.S. pregnancy-related mortality ratio increased as did the contribution of cardiovascular conditions and infection to pregnancy-related mortality. Although the identification of pregnancy-related deaths may be improving in the United States, the increasing contribution of chronic diseases to pregnancy-related mortality suggests a change in risk profile of the birthing population. C1 [Creanga, Andreea A.; Berg, Cynthia J.; Syverson, Carla; Seed, Kristi; Bruce, F. Carol; Callaghan, William M.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Creanga, AA (reprint author), Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, 4770 Buford Highway NE,Mail Stop K-23, Atlanta, GA 30341 USA. EM acreanga@cdc.gov NR 25 TC 113 Z9 113 U1 5 U2 27 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0029-7844 EI 1873-233X J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JAN PY 2015 VL 125 IS 1 BP 5 EP 12 DI 10.1097/AOG.0000000000000564 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AX1WZ UT WOS:000346735600003 PM 25560097 ER PT J AU Perkins, KM Boulet, SL Kissin, DM Jamieson, DJ AF Perkins, Kiran M. Boulet, Sheree L. Kissin, Dmitry M. Jamieson, Denise J. CA Natl ART Surveillance NASS Grp TI Risk of Ectopic Pregnancy Associated With Assisted Reproductive Technology in the United States, 2001-2011 SO OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 70th Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 18-22, 2014 CL Honolulu, HI SP Amer Soc Reprod Med ID IN-VITRO FERTILIZATION; THAWED EMBRYO-TRANSFER; INVITRO FERTILIZATION; CYCLES; RATES AB OBJECTIVE: To assess national trends in ectopic pregnancy incidence among assisted reproductive technology users and identify risk factors associated with ectopic pregnancy. METHODS: We identified 553,577 pregnancies reported to the National ART Surveillance System between 2001 and 2011. Of those, 9,480 were ectopic, of which 485 were heterotopic. As a result of small numbers, ectopic and heterotopic pregnancies were combined for analysis. We assessed temporal trends in annual ectopic pregnancy rates using Poisson regression. We used log-binomial regression models with generalized estimating equations for correlated outcomes within clinics to calculate unadjusted and adjusted risk ratios for the association between ectopic pregnancy and selected patient characteristics and treatment factors. RESULTS: The rate of ectopic pregnancy declined from 2.0% (n=735, 95% confidence interval [CI] 1.9-2.2) in 2001 to 1.6% (n=968, 95% CI 1.5-1.7) in 2011 (P for trend, <.001). The ectopic pregnancy rate ranged from 2.0% (n=7,469, 95% CI 1.9-2.0) for fresh, nondonor cycles to 1.0% (n=641, 95% CI 0.9-1.1) for fresh, donor cycles. Among fresh, nondonor cycles, the rate of ectopic pregnancy was 1.6% (95% CI 1.4-1.7) when one embryo was transferred compared with 1.7% (95% CI 1.7-1.8), 2.2% (95% CI 2.1-2.3), and 2.5% (95% CI 2.4-2.6) when two, three, or four or more embryos were transferred, respectively (adjusted risk ratios 1.11, 95% CI 0.94-0.30; 1.33, 95% CI 1.12-1.56; and 1.49, 95% CI 1.25-1.78). CONCLUSION: Ectopic pregnancy incidence after assisted reproductive technology has decreased over time, but factors such as multiple embryo transfer increase the risk of ectopic pregnancy. C1 Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Perkins, Kiran M.] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA 30341 USA. RP Perkins, KM (reprint author), Ctr Dis Control & Prevent, Epidem Intelligence Serv, 4770 Buford Highway NE,Mailstop F-74, Atlanta, GA 30341 USA. EM KPerkins@cdc.gov FU Intramural CDC HHS [CC999999] NR 28 TC 24 Z9 28 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0029-7844 EI 1873-233X J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JAN PY 2015 VL 125 IS 1 BP 70 EP 78 DI 10.1097/AOG.0000000000000584 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AX1WZ UT WOS:000346735600014 PM 25560107 ER PT J AU Kanter, JR Boulet, SL Kawwass, JF Jamieson, DJ Kissin, DM AF Kanter, Jessica R. Boulet, Sheree L. Kawwass, Jennifer F. Jamieson, Denise J. Kissin, Dmitry M. TI Trends and Correlates of Monozygotic Twinning After Single Embryo Transfer SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID ASSISTED REPRODUCTIVE TECHNOLOGY; UNITED-STATES; PREGNANCIES; RISK; IVF; CULTURE AB OBJECTIVE: To evaluate trends of monozygotic twinning after single embryo transfer and its association with patient and treatment factors. METHODS: Our retrospective cohort study included 28,596 pregnancies after fresh, nondonor single embryo transfer during 2003-2012 reported to the National ART Surveillance System. We examined trends of monozygotic twin pregnancies (number of fetal heart tones on first-trimester ultrasonography more than one or number of neonates born more than one) and assessed patient and treatment factors for monozygotic twin compared with singleton pregnancies. Modified Poisson regression models were used to estimate adjusted risk ratios (RRs) and 95% confidence intervals (CIs) for association between monozygotic twinning and selected factors stratified by day 2-3 and day 5-6 transfer. RESULTS: During 2003-2012, the incidence of monozygotic twinning after single embryo transfer was lower for day 2-3 transfers than for day 5-6 transfers (1.71%, 95% CI 1.45-1.98, n=162 compared with 2.50%, 95% CI 2.28-2.73, n=472); the incidence did not change significantly over the study period. Among day 2-3 transfers, assisted hatching increased the risk for monozygotic twinning compared with singletons (adjusted RR 2.16, 95% CI 1.53-3.06); use of intracytoplasmic sperm injection decreased the risk (adjusted RR 0.60, 95% CI 0.42-0.85). Having one or more prior pregnancies increased the risk for monozygotic twinning among day 5-6 transfers (adjusted RR 1.26, 95% CI 1.03-1.53). CONCLUSION: Monozygotic twinning after single embryo transfers was more common among day 5-6 embryo transfers than day 2-3 transfers. Use of assisted hatching was associated with increased risk for monozygotic twinning for day 2-3 transfers. C1 Emory Univ, Sch Med, Dept Gynecol & Obstet, Atlanta, GA USA. Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30341 USA. RP Boulet, SL (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, 4770 Buford Highway,Mailstop F74, Atlanta, GA 30341 USA. EM sboulet@cdc.gov FU Intramural CDC HHS [CC999999] NR 26 TC 8 Z9 9 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0029-7844 EI 1873-233X J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JAN PY 2015 VL 125 IS 1 BP 111 EP 117 DI 10.1097/AOG.0000000000000579 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AX1WZ UT WOS:000346735600019 PM 25560112 ER PT J AU Leffert, LR Clancy, CR Bateman, BT Bryant, AS Kuklina, EV AF Leffert, Lisa R. Clancy, Caitlin R. Bateman, Brian T. Bryant, Allison S. Kuklina, Elena V. TI Hypertensive Disorders and Pregnancy-Related Stroke Frequency, Trends, Risk Factors, and Outcomes SO OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 46th Annual Meeting of the Society-for-Obstetric-Anesthesia-and-Perinatology CY MAY 14-18, 2014 CL Toronto, CANADA SP Soc Obstet Anesthesia & Perinatol ID HEALTH-CARE PROFESSIONALS; UNITED-STATES; INTRAVENOUS THROMBOLYSIS; MATERNAL MORBIDITY; HEMORRHAGIC STROKE; PREECLAMPSIA; HOSPITALIZATIONS; ASSOCIATION; PREVALENCE; ADULTS AB OBJECTIVE: To evaluate trends and associations of hypertensive disorders of pregnancy with stroke risk and test the hypothesis that hypertensive disorders of pregnancy-associated stroke results in higher rates of stroke-related complications than pregnancy-associated stroke without hypertensive disorders. METHODS: A cross-sectional study was performed using 81,983,216 pregnancy hospitalizations from the 1994-2011 Nationwide Inpatient Sample. Rates of stroke hospitalizations with and without these hypertensive disorders were reported per 10,000 pregnancy hospitalizations. Using logistic regression, adjusted odds ratios (OR) with 95% confidence intervals were obtained. RESULTS: Between 1994-1995 and 2010-2011, the nationwide rate of stroke with hypertensive disorders of pregnancy increased from 0.8 to 1.6 per 10,000 pregnancy hospitalizations (103%), whereas the rate without these disorders increased from 2.2 to 3.2 per 10,000 pregnancy hospitalizations (47%). Women with hypertensive disorders of pregnancy were 5.2 times more likely to have a stroke than those without. Having traditional stroke risk factors (eg, congenital heart disease, atrial fibrillation, sickle cell anemia, congenital coagulation defects) substantially increased the stroke risk among hypertensive disorders of pregnancy hospitalizations: from adjusted OR 2.68 for congenital coagulation defects to adjusted OR 13.1 for congenital heart disease. Stroke-related complications were increased in stroke with hypertensive disorders of pregnancy compared with without (from adjusted OR 1.23 for nonroutine discharge to adjusted OR 1.93 for mechanical ventilation). CONCLUSION: Having traditional stroke risk factors substantially increased the stroke risk among hypertensive disorders of pregnancy hospitalizations. Stroke with hypertensive disorders in pregnancy had two distinctive characteristics: a greater increase in frequency since themid-1990s and significantly higher stroke-related complication rates. C1 Massachusetts Gen Hosp, Dept Anesthesia, Obstet Anesthesia Div, Boston, MA 02114 USA. Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA. Massachusetts Gen Hosp, Dept Obstet & Gynecol, Boston, MA 02114 USA. Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA USA. RP Leffert, LR (reprint author), Massachusetts Gen Hosp, Div Obstet Anesthesia, Dept Anesthesia Crit Care & Pain Med, 55 Fruit St, Boston, MA 02114 USA. EM lleffert@partners.org FU Intramural CDC HHS [CC999999] NR 31 TC 14 Z9 15 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0029-7844 EI 1873-233X J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JAN PY 2015 VL 125 IS 1 BP 124 EP 131 DI 10.1097/AOG.0000000000000590 PG 8 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AX1WZ UT WOS:000346735600021 PM 25560114 ER PT J AU Louie, JK Salibay, CJ Kang, M Glenn-Finer, RE Murray, EL Jamieson, DJ AF Louie, Janice K. Salibay, Catheryn J. Kang, Monica Glenn-Finer, Rose E. Murray, Erin L. Jamieson, Denise J. TI Pregnancy and Severe Influenza Infection in the 2013-2014 Influenza Season SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID UNITED-STATES; A H1N1; RESPIRATORY ILLNESS; POSTPARTUM WOMEN; VIRUS ILLNESS; VACCINATION; INFANTS; HOSPITALIZATIONS; CALIFORNIA; IMMUNIZATION AB OBJECTIVE: To describe the epidemiologic and clinical characteristics of critically ill pregnant and postpartum women with influenza infection reported in the 2013-2014 season. METHODS: The California Department of Public Health conducts surveillance for patients with laboratory-confirmed influenza who die or require hospitalization in intensive care units. For this case series, we reviewed data on pregnant and postpartum (6 weeks or less from delivery) women reported in the 2013-2014 influenza season. RESULTS: From September 29, 2013, through May 17, 2014, 17 pregnant women with severe influenza were reported. The median age was 29 years (range 17-44 years). Sixteen (94%) were in the second or third trimester. Fifteen (88%) patients were hospitalized, nine (53%) required mechanical ventilation, five (29%) required emergent cesarean delivery, and four (24%) died. Of 14 patients with available information, only two (14%) received influenza vaccination during pregnancy. Seven patients who tested positive by polymerase chain reaction also had rapid influenza diagnostic testing performed; only one (14%) had a positive rapid influenza diagnostic test results. Fifteen patients received antiviral treatment; four (27%) began treatment within 48 hours of symptom onset. One additional patient was 36 days postpartum and required intensive care unit admission and mechanical ventilation for influenza-associated acute respiratory distress syndrome. CONCLUSION: Influenza remains a significant cause of morbidity and mortality in pregnant and postpartum women; in our series, a majority were not vaccinated. During the influenza season, pregnant women with suspected influenza should receive prompt empiric antiviral therapy, regardless of rapid influenza diagnostic test results or vaccination status. C1 Calif Dept Publ Hlth, Richmond, CA USA. Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Louie, JK (reprint author), Calif Correct Hlth Care Serv, POB 588500, Elk Grove, CA 95758 USA. EM janice.louie@cdcr.ca.gov NR 32 TC 11 Z9 11 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0029-7844 EI 1873-233X J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JAN PY 2015 VL 125 IS 1 BP 184 EP 192 DI 10.1097/AOG.0000000000000593 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AX1WZ UT WOS:000346735600030 PM 25560123 ER PT J AU Shapiro-Mendoza, CK Colson, ER Willinger, M Rybin, DV Camperlengo, L Corwin, MJ AF Shapiro-Mendoza, Carrie K. Colson, Eve R. Willinger, Marian Rybin, Denis V. Camperlengo, Lena Corwin, Michael J. TI Trends in Infant Bedding Use: National Infant Sleep Position Study, 1993-2010 SO PEDIATRICS LA English DT Article ID DEATH-SYNDROME; RISK-FACTORS; SUDDEN; ENVIRONMENT AB BACKGROUND: Use of potentially hazardous bedding, as defined by the American Academy of Pediatrics (eg, pillows, quilts, comforters, loose bedding), is a modifiable risk factor for sudden infant death syndrome and unintentional sleep-related suffocation. The proportion of US infants sleeping with these types of bedding is unknown. METHODS: To investigate the US prevalence of and trends in bedding use, we analyzed 1993-2010 data from the National Infant Sleep Position study. Infants reported as being usually placed to sleep with blankets, quilts, pillows, and other similar materials under or covering them in the last 2 weeks were classified as bedding users. Logistic regression was used to describe characteristics associated with bedding use. RESULTS: From 1993 to 2010, bedding use declined but remained a widespread practice (moving average of 85.9% in 1993-1995 to 54.7% in 2008-2010). Prevalence was highest for infants of teen-aged mothers (83.5%) and lowest for infants born at term (55.6%). Bedding use was also frequently reported among infants sleeping in adult beds, on their sides, and on a shared surface. The rate of decline in bedding use was markedly less from 2001-2010 compared with 1993-2000. For 2007 to 2010, the strongest predictors (adjusted odds ratio: >= 1.5) of bedding use were young maternal age, non-white race and ethnicity, and not being college educated. CONCLUSIONS: Bedding use for infant sleep remains common despite recommendations against this practice. Understanding trends in bedding use is important for tailoring safe sleep interventions. C1 [Shapiro-Mendoza, Carrie K.; Camperlengo, Lena] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30341 USA. [Colson, Eve R.] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06510 USA. [Willinger, Marian] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Pregnancy & Perinatol Branch, Bethesda, MD USA. [Rybin, Denis V.] Boston Univ, Sch Publ Hlth, Data Coordinating Ctr, Boston, MA USA. [Corwin, Michael J.] Boston Univ, Sch Med, Dept Pediat, Boston, MA 02118 USA. [Corwin, Michael J.] Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA. RP Shapiro-Mendoza, CK (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, MS F74,4770 Buford Highway NE, Atlanta, GA 30341 USA. EM ayn9@cdc.gov OI Rybin, Denis/0000-0002-3657-4829 FU Eunice Kennedy Shriver National Institute of Child Health and Human Development [U10 HD029067-09A1]; National Institutes of Health (NIH) FX Supported in part by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant U10 HD029067-09A1). Funded by the National Institutes of Health (NIH). NR 21 TC 13 Z9 13 U1 0 U2 10 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD JAN PY 2015 VL 135 IS 1 BP 10 EP 17 DI 10.1542/peds.2014-1793 PG 8 WC Pediatrics SC Pediatrics GA AX8PX UT WOS:000347172200043 PM 25452654 ER PT J AU Jules, A Grijalva, CG Zhu, YW Mphc, KTM Williams, JV Poehling, KA Chaves, SS Edwards, KM Schaffner, W Shay, DK Griffin, MR AF Jules, Astride Grijalva, Carlos G. Zhu, Yuwei Talbot, H. Keipp Williams, John V. Poehling, Katherine A. Chaves, Sandra S. Edwards, Kathryn M. Schaffner, William Shay, David K. Griffin, Marie R. TI Influenza-Related Hospitalization and ED Visits in Children Less Than 5 Years: 2000-2011 SO PEDIATRICS LA English DT Article ID IMMUNIZATION PRACTICES ACIP; LABORATORY-CONFIRMED INFLUENZA; RESPIRATORY SYNCYTIAL VIRUS; YOUNG-CHILDREN; UNITED-STATES; VACCINE EFFECTIVENESS; ADVISORY-COMMITTEE; BURDEN; RECOMMENDATIONS; AGE AB BACKGROUND AND OBJECTIVES: In the United States, recommendations for annual influenza vaccination gradually expanded from 2004 to 2008, to include all children aged >= 6 months. The effects of these policies on vaccine uptake and influenza-associated health care encounters are unclear. The objectives of the study were to examine the annual incidence of influenza-related health care encounters and vaccine uptake among children age 6 to 59 months from 2000-2001 through 2010-2011 in Davidson County, TN. METHODS: We estimated the proportion of laboratory-confirmed influenza-related hospitalizations and emergency department (ED) visits by enrolling and testing children with acute respiratory illness or fever. We estimated influenza-related health care encounters by multiplying these proportions by the number of acute respiratory illness/fever hospitalizations and ED visits for county residents. We assessed temporal trends in vaccination coverage, and influenza-associated hospitalizations and ED visit rates. RESULTS: The proportion of fully vaccinated children increased from 6% in 2000-2001 to 38% in 2010-2011 (P<.05). Influenza-related hospitalizations ranged from 1.9 to 16.0 per 10 000 children (median 4.5) per year. Influenza-related ED visits ranged from 89 to 620 per 10 000 children (median 143) per year. Significant decreases in hospitalizations (P<.05) and increases in ED visits (P<.05) over time were not clearly related to vaccination trends. Influenza-related encounters were greater when influenza A(H3N2) circulated than during other years with median rates of 8.2 vs 3.2 hospitalizations and 307 vs 143 ED visits per 10 000 children, respectively. CONCLUSIONS: Influenza vaccination increased over time; however, the proportion of fully vaccinated children remained <50%. Influenza was associated with a substantial illness burden particularly when influenza A(H3N2) predominated. C1 [Jules, Astride; Grijalva, Carlos G.; Schaffner, William; Griffin, Marie R.] Vanderbilt Univ, Sch Med, Dept Hlth Policy, Nashville, TN 37212 USA. [Zhu, Yuwei] Vanderbilt Univ, Sch Med, Dept Biostat, Nashville, TN 37212 USA. [Talbot, H. Keipp; Griffin, Marie R.] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA. [Williams, John V.; Edwards, Kathryn M.] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA. [Williams, John V.] Vanderbilt Univ, Sch Med, Dept Pathol Microbiol & Immunol, Nashville, TN 37212 USA. [Poehling, Katherine A.] Wake Forest Sch Med, Dept Pediat, Winston Salem, NC USA. [Poehling, Katherine A.] Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA. [Chaves, Sandra S.; Shay, David K.] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Griffin, MR (reprint author), Vanderbilt Univ, Med Ctr, Dept Hlth Policy, Ste 2600,1500 21st Ave S, Nashville, TN 37212 USA. EM marie.griffin@vanderbilt.edu OI Shay, David/0000-0001-9619-4820 FU Centers for Disease Control and Prevention [U01 IP000184, U38/CCU217969, U38/CCU417958, U38/CCU522352, U01/IP000017, U01/IP000022, U01/IP000147]; National Institutes of Health Clinical and Translational Science Award from the National Center for Advancing Translational Sciences [UL1TR000445]; National Institutes of Health (NIH) FX Supported by the Centers for Disease Control and Prevention through a cooperative agreement of U01 IP000184 and cooperative agreements U38/CCU217969, U38/CCU417958, U38/CCU522352, U01/IP000017, U01/IP000022, and U01/IP000147. This project also was supported by National Institutes of Health Clinical and Translational Science Award UL1TR000445 from the National Center for Advancing Translational Sciences. Its contents are solely the responsibility of the authors and do not necessarily represent official views of the National Center for Advancing Translational Sciences, the National Institutes of Health, or the Centers for Disease Control and Prevention. Funded by the National Institutes of Health (NIH). NR 39 TC 5 Z9 5 U1 0 U2 4 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD JAN PY 2015 VL 135 IS 1 BP E66 EP E74 DI 10.1542/peds.2014-1168 PG 9 WC Pediatrics SC Pediatrics GA AX8PX UT WOS:000347172200010 PM 25489015 ER PT J AU Benowitz, I Ackelsberg, J Balter, SE Baumgartner, JC Dentinger, C Fine, AD Harper, SA Jones, LE Laraque, F Lee, EH Merizalde, G Quinn, C Slavinski, S Winters, AI Weiss, D Yacisin, KA Varma, JK Layton, MC AF Benowitz, Isaac Ackelsberg, Joel Balter, Sharon E. Baumgartner, Jennifer C. Dentinger, Catherine Fine, Anne D. Harper, Scott A. Jones, Lucretia E. Laraque, Fabienne Lee, Ellen H. Merizalde, Giselle Quinn, Celia Slavinski, Sally Winters, Ann I. Weiss, Don Yacisin, Kari A. Varma, Jay K. Layton, Marcelle C. TI Surveillance and Preparedness for Ebola Virus Disease-New York City, 2014 SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Article AB This report details the New York City Department of Health and Mental Hygiene algorithm for evaluating patients with possible Ebola virus, recommendations that are pertinent for other areas in the United States caring for patients at risk for Ebola. For transplantation-specific recommendations, see editorial by Kaul et al on page . C1 [Benowitz, Isaac; Yacisin, Kari A.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Benowitz, Isaac; Ackelsberg, Joel; Balter, Sharon E.; Baumgartner, Jennifer C.; Dentinger, Catherine; Fine, Anne D.; Harper, Scott A.; Jones, Lucretia E.; Laraque, Fabienne; Lee, Ellen H.; Merizalde, Giselle; Slavinski, Sally; Winters, Ann I.; Weiss, Don; Varma, Jay K.; Layton, Marcelle C.] Bur Communicable Dis, Dept Hlth & Mental Hyg, New York, NY USA. [Dentinger, Catherine; Harper, Scott A.; Quinn, Celia] CDC, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. [Quinn, Celia] Dept Hlth & Mental Hyg, Off Emergency Planning & Response, New York, NY USA. [Yacisin, Kari A.] Dept Hlth & Mental Hyg, Div Epidemiol, New York, NY USA. RP Benowitz, I (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM ibenowitz@cdc.gov NR 7 TC 0 Z9 0 U1 2 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1600-6135 EI 1600-6143 J9 AM J TRANSPLANT JI Am. J. Transplant. PD JAN PY 2015 VL 15 IS 1 BP 278 EP 280 DI 10.1111/ajt.13114 PG 3 WC Surgery; Transplantation SC Surgery; Transplantation GA AX2JM UT WOS:000346769500034 ER PT J AU Ghasemzadeh, N Hritani, AW De Staercke, C Eapen, DJ Veledar, E Al Kassem, H Khayata, M Zafari, AM Sperling, L Hooper, C Vaccarino, V Mavromatis, K Quyyumi, AA AF Ghasemzadeh, Nima Hritani, Abdul Wahab De Staercke, Christine Eapen, Danny J. Veledar, Emir Al Kassem, Hatem Khayata, Mohamed Zafari, A. Maziar Sperling, Laurence Hooper, Craig Vaccarino, Viola Mavromatis, Kreton Quyyumi, Arshed A. TI Plasma stromal cell-derived factor 1 alpha/CXCL12 level predicts long-term adverse cardiovascular outcomes in patients with coronary artery disease SO ATHEROSCLEROSIS LA English DT Article DE Stromal cell-derived factor1 alpha; CXCL12; Coronary artery disease; Cardiovascular outcomes ID MIGRATION INHIBITORY FACTOR; PROGENITOR CELLS; FACTOR-I; MYOCARDIAL-INFARCTION; FACTOR-1-ALPHA; RISK; STEM; RECRUITMENT; INVOLVEMENT; HEART AB Objective: Stromal derived factor-1 alpha/CXCL12 is a chemoattractant responsible for homing of progenitor cells to ischemic tissues. We aimed to investigate the association of plasma CXCL12 with long-term cardiovascular outcomes in patients with coronary artery disease (CAD). Methods: 785 patients aged: 63 +/- 12 undergoing coronary angiography were independently enrolled into discovery (N = 186) and replication (N = 599) cohorts. Baseline levels of plasma CXCL12 were measured using Quantikine CXCL12 ELISA assay (R&D systems). Patients were followed for cardiovascular death and/or myocardial infarction (MI) for a mean of 2.6 yrs. Cox proportional hazard was used to determine independent predictors of cardiovascular death/MI. Results: The incidence of cardiovascular death/MI was 13% (N = 99). High CXCL12 level based on best discriminatory threshold derived from the ROC analysis predicted risk of cardiovascular death/MI (HR = 4.81, p = 1 x 10(-6)) independent of traditional risk factors in the pooled cohort. Addition of CXCL12 to a baseline model was associated with a significant improvement in c-statistic (AUC: 0.67-0.73, p = 0.03). Addition of CXCL12 was associated with correct risk reclassification of 40% of events and 10.5% of non-events. Similarly for the outcome of cardiovascular death, the addition of the CXCL12 to the baseline model was associated with correct reclassification of 20.7% of events and 9% of non-events. These results were replicated in two independent cohorts. Conclusion: Plasma CXCL12 level is a strong independent predictor of adverse cardiovascular outcomes in patients with CAD and improves risk reclassification. (C) 2014 Elsevier Ireland Ltd. All rights reserved. C1 [Ghasemzadeh, Nima; Hritani, Abdul Wahab; Eapen, Danny J.; Al Kassem, Hatem; Khayata, Mohamed; Zafari, A. Maziar; Sperling, Laurence; Vaccarino, Viola; Mavromatis, Kreton; Quyyumi, Arshed A.] Emory Univ, Sch Med, Atlanta, GA USA. [De Staercke, Christine; Hooper, Craig] Ctr Dis Control & Prevent, Atlanta, GA USA. [Veledar, Emir] Florida Int Univ, Dept Biostat, Miami, FL 33199 USA. [Veledar, Emir; Vaccarino, Viola] Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA. [Zafari, A. Maziar; Mavromatis, Kreton] Atlanta Vet Affairs Med Ctr, Decatur, GA USA. RP Quyyumi, AA (reprint author), Emory Clin Cardiovasc Res Inst, 1462 Clifton Rd NE,Suite 507, Atlanta, GA 30322 USA. EM aquyyum@emory.edu RI Veledar, Emir/K-2808-2012; Khayata, Mohamed /I-5288-2015; OI Veledar, Emir/0000-0002-3831-5433; KHAYATA, MOHAMED/0000-0001-8116-4311 FU Robert W. Woodruff Health Sciences Center Fund (Atlanta); Emory Heart and Vascular Center (Atlanta); Katz Family Foundation Preventive Cardiology Grant (Atlanta); NIH [UL1 RR025008]; Clinical and Translational Science Award program NIH [R01HL089650-02] FX Funding for collection and management of samples was received from the Robert W. Woodruff Health Sciences Center Fund (Atlanta, GA), Emory Heart and Vascular Center (Atlanta, GA), Katz Family Foundation Preventive Cardiology Grant (Atlanta, GA) and NIH Grant UL1 RR025008 from the Clinical and Translational Science Award program NIH grant R01HL089650-02. NR 34 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0021-9150 EI 1879-1484 J9 ATHEROSCLEROSIS JI Atherosclerosis PD JAN PY 2015 VL 238 IS 1 BP 113 EP 118 DI 10.1016/j.atherosclerosis.2014.10.094 PG 6 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AX1WR UT WOS:000346734600019 PM 25461737 ER PT J AU Wu, XM Bennett, DH Calafat, AM Kato, K Strynar, M Andersen, E Moran, RE Tancredi, DJ Tulve, NS Hertz-Picciotto, I AF Wu, Xiangmei (May) Bennett, Deborah H. Calafat, Antonia M. Kato, Kayoko Strynar, Mark Andersen, Erik Moran, Rebecca E. Tancredi, Daniel J. Tulve, Nicolle S. Hertz-Picciotto, Irva TI Serum concentrations of perfluorinated compounds (PFC) among selected populations of children and Adults in California SO ENVIRONMENTAL RESEARCH LA English DT Article DE Perfluorinated compounds; Serum; Children; Within-family correlation; Temporal variation ID NATIONAL BIRTH COHORT; IN-HOUSE DUST; PERFLUOROOCTANE SULFONATE; POLYFLUOROALKYL COMPOUNDS; POLYFLUORINATED COMPOUNDS; PERFLUOROALKYL ACIDS; DIETARY EXPOSURE; INDOOR AIR; HALF-LIFE; CHEMICALS AB Perfluorinated compounds (PFCs) have been widely used in industrial applications and consumer products. Their persistent nature and potential health impacts are of concern. Given the high cost of collecting serum samples, this study is to understand whether we can quantify PFC serum concentrations using factors extracted from questionnaire responses and indirect measurements, and whether a single serum measurement can be used to classify an individual's exposure over a one-year period. The study population included three demographic groups: young children (2-8 years old) (N=67), parents of young children (< 55 years old) (N=90), and older adults ( > 55 years old) (N=59). PFC serum concentrations, house dust concentrations, and questionnaires were collected. The geometric mean of perfluorooctane sulfonic acid (PFOS) was highest for the older adults. In contrast, the geometric mean of perfluorooctanoic acid (PFOA) was highest for children. Serum concentrations of the parent and the child from the same family were moderately correlated (Spearman correlation (r)=0.26-0.79, p <0.05), indicating common sources within a family. For adults, age, having occupational exposure or having used fire extinguisher, frequencies of consuming butter/margarine, pork, canned meat entres, tuna and white fish, freshwater fish, and whether they ate microwave popcorn were significantly positively associated with serum concentrations of individual PFCs. For children, residential dust concentrations, frequency of wearing waterproof clothes, frequency of having canned fish, hotdogs, chicken nuggets, French fries, and chips, and whether they ate microwave popcorn were significant positive predictors of individual PFC serum concentrations. In addition, the serum concentrations collected in a subset of young children (N=20) and the parents (N=42) one year later were strongly correlated (r=0.68-0.98, p <0.001) with the levels measured at the first visits, but showed a decreasing trend. Children had moderate correlation (r=0.43) between serum and dust concentrations. of PFOS, indicating indoor sources contribute to exposure. In conclusion, besides food intake, occupational exposure, consumer product use, and exposure to residential dust contribute to PFC exposure. The downward temporal trend of serum concentrations reflects the reduction of PFCs use in recent years while the year-to-year correlation indicates that a single serum measurement could be an estimate of exposure relative to the population for a one-year period in epidemiology studies. (C) 2014 Elsevier Inc. All rights reserved. C1 [Wu, Xiangmei (May); Bennett, Deborah H.; Moran, Rebecca E.; Hertz-Picciotto, Irva] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA. [Calafat, Antonia M.; Kato, Kayoko] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA. [Strynar, Mark; Andersen, Erik] US EPA, Human Exposure & Atmospher Sci Div, Methods Dev & Applicat Branch, Durham, NC 27711 USA. [Tancredi, Daniel J.] Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA. [Tulve, Nicolle S.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC USA. RP Wu, XM (reprint author), Univ Calif Davis, Dept Publ Hlth Sci, One Shields Ave,MS1C, Davis, CA 95616 USA. EM xmwu@phs.ucdavis.edu; dhbennett@ucdavis.edu; aic7@cdc.gov; ktk2@cdc.gov; Strynar.Mark@epa.gov; andersen.erik@epa.gov; rmoran@ucdavis.edu; djtancredi@ucdavis.edu; Tulve.Nicolle@epa.gov; ihp@ucdavis.edu RI Tancredi, Daniel/O-3381-2013 OI Tancredi, Daniel/0000-0002-3884-7907 FU U.S. Environmental Protection Agency (US EPA) [RD-83154001]; Autism Speaks FX This research was funded by a Science to Achieve Results (STAR) grant #RD-83154001 from the U.S. Environmental Protection Agency (US EPA). Environmental sample analysis was conducted by the U.S. EPA's Office of Research and Development's National Exposure Research Laboratory, and blood sample analysis was conducted by the Centers for Disease Control and Prevention Laboratory (CDC). Data analysis was conducted with funding from Autism Speaks. NR 64 TC 16 Z9 16 U1 4 U2 56 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 EI 1096-0953 J9 ENVIRON RES JI Environ. Res. PD JAN PY 2015 VL 136 BP 264 EP 273 DI 10.1016/j.envres.2014.09.026 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AX2DY UT WOS:000346755000033 PM 25460645 ER PT J AU Shinnick, TM Starks, AM Alexander, HL Castro, KG AF Shinnick, Thomas M. Starks, Angela M. Alexander, Heather L. Castro, Kenneth G. TI Evaluation of the Cepheid Xpert MTB/RIF assay SO EXPERT REVIEW OF MOLECULAR DIAGNOSTICS LA English DT Review DE automated nucleic acid amplification; molecular detection of resistance; rifampicin resistance; tuberculosis ID RESISTANT MYCOBACTERIUM-TUBERCULOSIS; NEGATIVE PULMONARY TUBERCULOSIS; POSITIVE RIFAMPICIN RESISTANCE; DRIED CULTURE SPOTS; SOUTH-AFRICA; ANTIRETROVIRAL THERAPY; COST-EFFECTIVENESS; UNITED-STATES; GENEXPERT MTB/RIF; SMEAR MICROSCOPY AB The lack of capacity to provide laboratory confirmation of a diagnosis of tuberculosis disease (TB) is contributing to enormous gaps in the ability to find, treat and follow TB patients. WHO estimates that globally only about 57% of the notified new cases of pulmonary TB in 2012 and about 19% of rifampicin-resistant TB cases were laboratory confirmed. The Cepheid Xpert((R)) MTB/RIF assay has been credited with revolutionizing laboratory testing to aid in the diagnosis of TB and rifampicin-resistant TB. This semi-automated test can detect both the causative agent of TB and mutations that confer rifampicin resistance from clinical specimens within 2 h after starting the test. In this article, we review the performance of the test, its pathway to regulatory approval and endorsement, guidelines for its use and lessons learned from the implementation of the test in low-burden, high-resource countries and in high-burden, low-resource countries. C1 [Shinnick, Thomas M.; Starks, Angela M.; Castro, Kenneth G.] Ctr Dis Control & Prevent, Div TB Eliminat, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. [Alexander, Heather L.] Ctr Dis Control & Prevent, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Castro, KG (reprint author), Ctr Dis Control & Prevent, Div TB Eliminat, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA 30333 USA. EM kgcastro1@gmail.com NR 96 TC 2 Z9 2 U1 1 U2 8 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1473-7159 EI 1744-8352 J9 EXPERT REV MOL DIAGN JI Expert Rev. Mol. Diagn. PD JAN PY 2015 VL 15 IS 1 BP 9 EP 22 DI 10.1586/14737159.2015.976556 PG 14 WC Pathology SC Pathology GA AX4KF UT WOS:000346900900003 PM 25373876 ER PT J AU Koul, PA Khan, UH Asad, R Yousuf, R Broor, S Lal, RB Dawood, FS AF Koul, Parvaiz A. Khan, Umar H. Asad, Romana Yousuf, Rubaya Broor, Shobha Lal, Renu B. Dawood, Fatimah S. TI Contribution of influenza to acute exacerbations of chronic obstructive pulmonary disease in Kashmir, India, 2010-2012 SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Article DE Chronic obstructive lung disease; chronic obstructive; hospitalization; influenza viruses; pulmonary disease ID COPD AB We estimate the contribution of influenza to hospitalizations for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in Kashmir, India. Prospective surveillance for influenza among patients hospitalized with AECOPD was conducted at a tertiary care hospital. Patients had clinical data collected and nasal/throat swabs tested for influenza viruses. Outcomes among patients with and without influenza were compared with logistic regression adjusting for age and underlying conditions. During October 2010-September 2012, 498 patients hospitalized with AECOPD were enrolled, of whom 40 (8%) had received influenza vaccine. Forty (8%) had influenza; influenza virus detection peaked in winter (January-March). Patients with influenza were more likely to die during hospitalization (adjusted OR 34, CI 10-114) than those without. C1 [Koul, Parvaiz A.; Khan, Umar H.; Asad, Romana; Yousuf, Rubaya] Sherikashmir Inst Med Sci, Dept Internal & Pulm Med, Srinagar 190011, Jammu & Kashmir, India. [Broor, Shobha] All India Inst Med Sci, New Delhi, India. [Lal, Renu B.; Dawood, Fatimah S.] CDC, Influenza Div, Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RP Dawood, FS (reprint author), Ctr Dis Control & Prevent, Influenza Div, 1600 Clifton Rd NE,MS A-32, Atlanta, GA 30333 USA. EM parvaizk@gmail.com; fdawood@cdc.gov NR 14 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1750-2640 EI 1750-2659 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD JAN PY 2015 VL 9 IS 1 BP 40 EP 42 DI 10.1111/irv.12291 PG 3 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA AX0PJ UT WOS:000346653800006 PM 25524051 ER PT J AU Smith, JM Srinivasan, P Teller, RS Lo, YT Dinh, CT Kiser, PF Herold, BC AF Smith, James M. Srinivasan, Priya Teller, Ryan S. Lo, Yungtai Dinh, Chuong T. Kiser, Patrick F. Herold, Betsy C. TI Tenofovir Disoproxil Fumarate Intravaginal Ring Protects High-Dose Depot Medroxyprogesterone Acetate-Treated Macaques From Multiple SHIV Exposures SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE macaque; intravaginal ring; TDF; Depo-Provera; PrEP ID PREEXPOSURE PROPHYLAXIS; HIV PREVENTION; ANIMAL-MODELS; CHALLENGES; INFECTION; TECHNOLOGY; EFFICACY; SAFETY AB Preclinical HIV prevention models use either a single high-dose viral challenge in depot medroxyprogesterone acetate-treated macaques or repeated viral challenges in cycling macaques. We tested the efficacy of an intravaginal tenofovir disoproxil fumarate (TDF) ring in a model combining repeated 30-mg injections of depot medroxyprogesterone acetate every 6 weeks with vaginal viral challenges weekly for 12 weeks. Twelve macaques were randomized to TDF or placebo rings. All placebo macaques became infected after a median of 2 exposures, whereas only 1 TDF macaque became infected at the eighth exposure (P = 0.0012). The TDF ring provides durable protection in a stringent challenge model. C1 [Smith, James M.; Srinivasan, Priya] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA USA. [Teller, Ryan S.; Kiser, Patrick F.] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA. [Lo, Yungtai] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA. [Dinh, Chuong T.] Total Solut Inc, Atlanta, GA USA. [Herold, Betsy C.] Albert Einstein Coll Med, Dept Pediat & Microbiol Immunol, Bronx, NY 10461 USA. RP Herold, BC (reprint author), Albert Einstein Coll Med, 1300 Morris Pk Ave,Forchheimer 702, Bronx, NY 10461 USA. EM betsy.herold@einstein.yu.edu RI Kiser, Patrick/C-2843-2014 OI Kiser, Patrick/0000-0002-3868-7122 FU [U19AI03461]; [U19AI076980] FX Supported by U19AI03461 and U19AI076980. NR 15 TC 12 Z9 12 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD JAN 1 PY 2015 VL 68 IS 1 BP 1 EP 5 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AX0LL UT WOS:000346643800008 PM 25321184 ER PT J AU Muraguri, N Tun, W Okal, J Broz, D Raymond, HF Kellogg, T Dadabhai, S Musyoki, H Sheehy, M Kuria, D Kaiser, R Geibel, S AF Muraguri, Nicholas Tun, Waimar Okal, Jerry Broz, Dita Raymond, H. Fisher Kellogg, Timothy Dadabhai, Sufia Musyoki, Helgar Sheehy, Meredith Kuria, David Kaiser, Reinhard Geibel, Scott TI HIV and STI Prevalence and Risk Factors Among Male Sex Workers and Other Men Who Have Sex With Men in Nairobi, Kenya SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE men who have sex with men; male sex work; HIV prevalence; STI prevalence; sexual behavior; Africa ID HIDDEN POPULATIONS; MOMBASA; MSM; INFECTION; KNOWLEDGE; TYPE-1 AB Previous surveys of men who have sex with men (MSM) in Africa have not adequately profiled HIV status and risk factors by sex work status. MSM in Nairobi, Kenya, were recruited using respondent-driven sampling, completed a behavioral interview, and were tested for HIV and sexually transmitted infections. Overlapping recruitment among 273 male sex workers and 290 other MSM was common. Sex workers were more likely to report receptive anal sex with multiple partners (65.7% versus 18.0%, P < 0.001) and unprotected receptive anal intercourse (40.0% versus 22.8%, P = 0.005). Male sex workers were also more likely to be HIV infected (26.3% versus 12.2%, P = 0.007). C1 [Muraguri, Nicholas] Minist Hlth, Nairobi, Kenya. [Tun, Waimar; Geibel, Scott] Populat Council, Washington, DC 20008 USA. [Okal, Jerry] Populat Council, Nairobi, Kenya. [Broz, Dita] Ctr Dis Control & Prevent, Div Global HIV AIDS, Atlanta, GA USA. [Raymond, H. Fisher; Kellogg, Timothy] San Francisco Dept Publ Hlth, San Francisco, CA USA. [Dadabhai, Sufia] Univ Calif San Francisco, Nairobi, Kenya. [Sheehy, Meredith] Populat Council, New York, NY 10021 USA. [Musyoki, Helgar] Natl AIDS & STD Control Programme, Nairobi, Kenya. [Kuria, David] Futures Grp Int, Hlth Policy Project, Nairobi, Kenya. [Kaiser, Reinhard] Ctr Dis Control & Prevent, Div Global HIV AIDS, Nairobi, Kenya. RP Geibel, S (reprint author), Populat Council, 4301 Connecticut Ave NW,Suite 280, Washington, DC 20008 USA. EM sgeibel@popcouncil.org FU President's Emergency Plan for AIDS Relief through Centers for Disease Control and Prevention through Population Council [5U62PS224506] FX Supported by the President's Emergency Plan for AIDS Relief through The Centers for Disease Control and Prevention, through the Population Council's cooperative agreement of Award no. 5U62PS224506. NR 24 TC 12 Z9 13 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD JAN 1 PY 2015 VL 68 IS 1 BP 91 EP 96 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AX0LL UT WOS:000346643800020 PM 25501346 ER PT J AU Hanson, KE Mansergh, G Koblin, BA Flores, SA Hudson, SM Myers, L Colfax, GN AF Hanson, Kayla E. Mansergh, Gordon Koblin, Beryl A. Flores, Stephen A. Hudson, Sharon M. Myers, Lynnea Colfax, Grant N. TI Depressive Symptoms by HIV Serostatus Are Differentially Associated With Unprotected Receptive and Insertive Anal Sex Among Substance-Using Men Who Have Sex With Men in the United States SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Letter ID RISK; INFECTION; HEALTH C1 [Hanson, Kayla E.; Mansergh, Gordon; Flores, Stephen A.] CDC Div HIV AIDS Prevent, Atlanta, GA 30329 USA. [Hanson, Kayla E.; Myers, Lynnea] Gustavus Adolphus Coll, St Peter, MN 56082 USA. [Koblin, Beryl A.] New York Blood Ctr, New York, NY 10021 USA. [Hudson, Sharon M.] Hlth Res Assoc, Los Angeles, CA USA. [Colfax, Grant N.] San Francisco Dept Publ Hlth, San Francisco, CA USA. RP Hanson, KE (reprint author), CDC Div HIV AIDS Prevent, Atlanta, GA 30329 USA. NR 15 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD JAN 1 PY 2015 VL 68 IS 1 BP E13 EP E16 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AX0LL UT WOS:000346643800005 PM 25321181 ER PT J AU Endegue-Zanga, MC Sadeuh-Mba, SA Iber, J Burns, C Nimpa-Mengouo, M Demanou, M Vernet, G Etoa, FX Njouom, R AF Endegue-Zanga, Marie Claire Sadeuh-Mba, Serge Alain Iber, Jane Burns, Cara Nimpa-Mengouo, Marcellin Demanou, Maurice Vernet, Guy Etoa, Francois-Xavier Njouom, Richard TI Circulating vaccine-derived polioviruses in the Extreme North region of Cameroon SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Vaccine-derived poliovirus; Acute-flaccid paralysis; Poliomyelitis; Cameroon ID POLIOMYELITIS ERADICATION; OUTBREAK; NIGERIA; TYPE-2; EMERGENCE; WORLDWIDE; PROGRESS; UPDATE AB Background: The World Health Organization (WHO) poliovirus eradication program includes careful surveillance of acute-flaccid paralysis (AFP) and mass and routine immunization with oral polio vaccine (OPV). In populations with low vaccine coverage, the live-attenuated Sabin strains, OPV types 1, 2 and 3, can evolve into virulent vaccine-derived polioviruses (VDPVs) and circulate in the community. Until recently, circulating VDPVs (cVDPVs) had not been reported in Cameroon despite the fact that VDPV2 outbreaks have occurred in nearby countries. Objectives: This study aimed to characterize virus isolates from four AFP patients infected with cVDPV2 in the Extreme North region of Cameroon in 2013. Study design: The complete VP1 region of the four VDPV strains was sequenced and the relationships with cVDPVs from neighboring countries were investigated. Results: All four patients were infected by cVDPV2 strains showing 1.2-2.0% nucleotide difference compared to the reference Sabin 2 VP1 sequence. Phylogenetic analysis indicated that the VDPV strains were genetically linked to cVDPV2 lineages of the recent Chad cVDPV2 outbreak. Conclusions: The circulation of pathogenic VDPVs suggests that there are localized immunization gaps in some districts like Makary, Mada and Kolofata in Cameroon. To avoid poliomyelitis outbreaks in Cameroon, especially in the districts close to neighboring countries with ongoing cVDPV outbreaks, high polio vaccine coverage is essential. (C) 2014 Elsevier B.V. All rights reserved. C1 [Endegue-Zanga, Marie Claire; Sadeuh-Mba, Serge Alain; Demanou, Maurice; Vernet, Guy; Njouom, Richard] Ctr Pasteur Cameroon, Yaounde, Cameroon. [Iber, Jane; Burns, Cara] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA USA. [Nimpa-Mengouo, Marcellin] WHO, Cameroon Country Off, Yaounde, Cameroon. [Etoa, Francois-Xavier] Univ Yaounde I, Yaounde, Cameroon. RP Njouom, R (reprint author), Ctr Pasteur Cameroon, POB 1274, Yaounde, Cameroon. EM njouom@pasteur-yaounde.org OI SADEUH-MBA, Serge Alain/0000-0003-3377-8225 FU WHO [TSA 2014/409463-0] FX This work was supported by a WHO grant (TSA 2014/409463-0), Technical Service Agreement (TSA) 2013. NR 21 TC 2 Z9 2 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD JAN PY 2015 VL 62 BP 80 EP 83 DI 10.1016/j.jcv.2014.11.027 PG 4 WC Virology SC Virology GA AX3RO UT WOS:000346856800018 PM 25542478 ER PT J AU Ramirez-Fort, MK Downing, C Doan, HQ Benoist, F Oberste, MS Khan, F Tyring, SK AF Ramirez-Fort, Marigdalia K. Downing, Christopher Doan, Hung Q. Benoist, Frances Oberste, M. Steven Khan, Farhan Tyring, Stephen K. TI Coxsackievirus A6 associated hand, foot and mouth disease in adults: Clinical presentation and review of the literature (vol 60, pg 381, 2014) SO JOURNAL OF CLINICAL VIROLOGY LA English DT Correction C1 [Ramirez-Fort, Marigdalia K.; Downing, Christopher; Khan, Farhan; Tyring, Stephen K.] Ctr Clin Studies, Houston, TX 77030 USA. [Ramirez-Fort, Marigdalia K.] Tufts Med Ctr, Dept Dermatol, Boston, MA USA. [Doan, Hung Q.; Benoist, Frances; Tyring, Stephen K.] Univ Texas Hlth Sci Ctr Houston, Dept Dermatol, Houston, TX 77030 USA. [Oberste, M. Steven] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. RP Tyring, SK (reprint author), Ctr Clin Studies, Houston, TX 77030 USA. EM styring@ccstexas.com NR 1 TC 0 Z9 0 U1 1 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD JAN PY 2015 VL 62 BP 123 EP 123 DI 10.1016/j.jcv.2014.11.008 PG 1 WC Virology SC Virology GA AX3RO UT WOS:000346856800028 ER PT J AU Antelman, G Medley, A Mbatia, R Pals, S Arthur, G Haberlen, S Ackers, M Elul, B Parent, J Rwebembera, A Wanjiku, L Muraguri, N Gweshe, J Mudhune, S Bachanas, P AF Antelman, Gretchen Medley, Amy Mbatia, Redempta Pals, Sherri Arthur, Gilly Haberlen, Sabina Ackers, Marta Elul, Batya Parent, Julie Rwebembera, Anath Wanjiku, Lucy Muraguri, Nicholas Gweshe, Justice Mudhune, Sandra Bachanas, Pamela CA Prevention Care Treatment Settings TI Pregnancy desire and dual method contraceptive use among people living with HIV attending clinical care in Kenya, Namibia and Tanzania SO JOURNAL OF FAMILY PLANNING AND REPRODUCTIVE HEALTH CARE LA English DT Article ID FERTILITY DESIRES; POSITIVE WOMEN; RURAL UGANDA; REPRODUCTIVE INTENTIONS; ANTIRETROVIRAL THERAPY; INFECTED INDIVIDUALS; SOUTH-AFRICA; COUPLES; MEN; SERVICES AB Aim To describe factors associated with pregnancy desire and dual method use among people living with HIV in clinical care in sub-Saharan Africa. Design Sexually active HIV-positive adults were enrolled in 18 HIV clinics in Kenya, Namibia and Tanzania. Demographic, clinical and reproductive health data were captured by interview and medical record abstraction. Correlates of desiring a pregnancy within the next 6 months, and dual method use [defined as consistent condom use together with a highly effective method of contraception (hormonal, intrauterine device (IUD), permanent)], among those not desiring pregnancy, were identified using logistic regression. Results Among 3375 participants (median age 37 years, 42% male, 64% on antiretroviral treatment), 565 (17%) desired a pregnancy within the next 6 months. Of those with no short-term fertility desire (n=2542), 686 (27%) reported dual method use, 250 (10%) highly effective contraceptive use only, 1332 (52%) condom use only, and 274 (11%) no protection. Respondents were more likely to desire a pregnancy if they were from Namibia and Tanzania, male, had a primary education, were married/cohabitating, and had fewer children. Factors associated with increased likelihood of dual method use included being female, being comfortable asking a partner to use a condom, and communication with a health care provider about family planning. Participants who perceived that their partner wanted a pregnancy were less likely to report dual method use. Conclusions There was low dual method use and low use of highly effective contraception. Contraceptive protection was predominantly through condom-only use. These findings demonstrate the importance of integrating reproductive health services into routine HIV care. C1 [Antelman, Gretchen] Columbia Univ, Mailman Sch Publ Hlth, ICAP, New York, NY 10032 USA. [Medley, Amy; Pals, Sherri; Bachanas, Pamela] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Mbatia, Redempta] Tanzania Hlth Promot Support, Dar Es Salaam, Tanzania. [Arthur, Gilly] CTS Global Inc, Sci, Dar Es Salaam, Tanzania. [Haberlen, Sabina] CTS Global Inc, Sci Off, Dar Es Salaam, Tanzania. [Ackers, Marta] US Ctr Dis Control & Prevent, HIV Care & Treatment Branch, Nairobi, Kenya. [Elul, Batya] Columbia Univ, Mailman Sch Publ Hlth, Strateg Informat ICAP, New York, NY 10032 USA. [Antelman, Gretchen; Elul, Batya] Columbia Univ, Mailman Sch Publ Hlth, New York, NY 10032 USA. [Parent, Julie; Gweshe, Justice] Minist Hlth & Social Serv, Windhoek, Namibia. [Rwebembera, Anath] Minist Hlth & Social Welf, Dar Es Salaam, Tanzania. [Wanjiku, Lucy] US Ctr Dis Control & Prevent, Nairobi, Kenya. [Muraguri, Nicholas] Minist Hlth, Med Serv, Nairobi, Kenya. [Gweshe, Justice] Minist Hlth & Social Serv, Natl Programme, Windhoek, Namibia. [Mudhune, Sandra] Columbia Univ, Mailman Sch Publ Hlth, Int Ctr AIDS Care & Treatment Programs ICAP, New York, NY 10032 USA. RP Antelman, G (reprint author), Columbia Univ, Mailman Sch Publ Hlth, 722 West 16th St, New York, NY 10032 USA. EM ga_zzz@yahoo.com FU President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention FX This research received funding support from the President's Emergency Plan for AIDS Relief (PEPFAR) through the Centers for Disease Control and Prevention. No competing financial interests exist. NR 44 TC 2 Z9 2 U1 0 U2 12 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1471-1893 EI 2045-2098 J9 J FAM PLAN REPROD H JI J. Fam. Plan. Reprod. Health Care PD JAN PY 2015 VL 41 IS 1 DI 10.1136/jfprhc-2013-100784 PG 12 WC Family Studies; Obstetrics & Gynecology; Social Sciences, Biomedical SC Family Studies; Obstetrics & Gynecology; Biomedical Social Sciences GA AX4LX UT WOS:000346905100001 PM 25512359 ER PT J AU Lebensburger, JD Grosse, SD Altice, JL Thierry, JM Ivankova, NV AF Lebensburger, Jeffrey D. Grosse, Scott D. Altice, Jessica L. Thierry, JoAnn M. Ivankova, Nataliya V. TI Understanding and Improving Health Education Among First-time Parents of Infants With Sickle Cell Anemia in Alabama: A Mixed Methods Approach SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY LA English DT Article DE parenting education; newborn screening; sickle cell anemia; qualitative research; quantitative research methodology ID CYSTIC-FIBROSIS; BABY HUG; DISEASE; INFORMATION; COMMUNICATION; EXPERIENCE; CHILDREN; TRIAL; HYDROXYUREA; PREFERENCE AB With the increase in access to medical information, parents can acquire health information from multiple sources. An understanding of parents' reactions to a newborn infant's diagnosis of sickle cell anemia and how they acquire knowledge can identify parent beliefs and preferences about the process of sickle cell education. This study utilized a sequential exploratory mixed methods design. First, qualitative interviews were conducted with 8 parents of infants with sickle cell anemia to understand the process of health education. Second, quantitative surveys were conducted with 22 other parents to test qualitative findings. Parents of infants with sickle cell anemia expressed a high level of fear at the time of notification of a positive screen. Parents desired an understanding of how to identify acute complications of disease and how sickle cell will alter their child's life. Parents actively sought information at the time they were told their child had sickle cell disease. Sickle cell education should begin at time of notification of positive newborn screening results and address identified parent concerns. Health care providers should build trust with parents and provide them with immediate access to educational materials. Hematologists should work with primary care providers to develop complementary educational programs and resources. C1 [Lebensburger, Jeffrey D.] Univ Alabama Birmingham, Div Pediat Hematol Oncol, Birmingham, AL 35233 USA. [Altice, Jessica L.] Univ Alabama Birmingham, Dept Human Studies, Birmingham, AL 35233 USA. [Ivankova, Nataliya V.] Univ Alabama Birmingham, Dept Hlth Serv Adm, Birmingham, AL 35233 USA. [Grosse, Scott D.; Thierry, JoAnn M.] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA. RP Lebensburger, JD (reprint author), Univ Alabama Birmingham, Div Pediat Hematol Oncol, 1600 7th Ave S,Lowder Bldg 512, Birmingham, AL 35233 USA. EM jlebensburger@peds.uab.edu FU Intramural CDC HHS [CC999999] NR 29 TC 1 Z9 1 U1 1 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1077-4114 EI 1536-3678 J9 J PEDIAT HEMATOL ONC JI J. Pediatr. Hematol. Oncol. PD JAN PY 2015 VL 37 IS 1 BP 35 EP 42 PG 8 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA AX0HO UT WOS:000346633800021 PM 25072367 ER PT J AU McKeown, RE Holbrook, JR Danielson, ML Cuffe, SP Wolraich, ML Visser, SN AF McKeown, Robert E. Holbrook, Joseph R. Danielson, Melissa L. Cuffe, Steven P. Wolraich, Mark L. Visser, Susanna N. TI The Impact of Case Definition on Attention-Deficit/Hyperactivity Disorder Prevalence Estimates in Community-Based Samples of School-Aged Children SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY LA English DT Article DE ADHD; diagnostic criteria; DSM-5; impairment; age of onset ID DEFICIT HYPERACTIVITY DISORDER; UNITED-STATES; PSYCHOMETRIC PROPERTIES; MENTAL-DISORDERS; PROPOSED CHANGES; RECENT TRENDS; ADHD; PARENT; DIAGNOSIS; MISUSE AB Objective: To determine the impact of varying attentiondeficit/hyperactivity disorder (ADHD) diagnostic criteria, including new DSM-5 criteria, on prevalence estimates. Method: Parent and teacher reports identified high- and low-screen children with ADHD from elementary schools in 2 states that produced a diverse overall sample. The parent interview stage included the Diagnostic Interview Schedule for Children-IV (DISC-IV), and up to 4 additional follow-up interviews. Weighted prevalence estimates, accounting for complex sampling, quantified the impact of varying ADHD criteria using baseline and the final follow-up interview data. Results: At baseline 1,060 caregivers were interviewed; 656 had at least 1 follow-up interview. Teachers and parents reported 6 or more ADHD symptoms for 20.5% (95% CI = 18.1%-23.2%) and 29.8% (CI = 24.5%-35.6%) of children respectively, with criteria for impairment and onset by age 7 years (DSM-IV) reducing these proportions to 16.3% (CI = 14.7%-18.0%) and 17.5% (CI = 13.3%22.8%); requiring at least 4 teacher-reported symptoms reduced the parerit-reported prevalence to 8.9% (CI = 7.4%-10.6%). Revising age of onset to 12 years per DSM-5 increased the 8.9% estimate to 11.3% (CI = 9.5%13.3%), with a similar increase seen at follow-up: 8.2% with age 7 onset (CI = 5.9%-11.2%) versus 13.0% (CI = 7.6%-21.4%) with onset by age 12. Reducing the number of symptoms required for those aged 17 and older increased the overall estimate to 13.1% (CI = 7.7%-21.5%). Conclusion: These findings quantify the impact on prevalence estimates of varying case definition criteria for ADHD. Further research of impairment ratings. and data from multiple informants is required to better inform clinicians conducting diagnostic assessments. DSM-5 changes in age of onset and number of symptoms required for older adolescents appear to increase prevalence estimates, although the full impact is uncertain due to the age of our sample. C1 [McKeown, Robert E.] Univ S Carolina, Arnold Sch Publ Hlth, Columbia, SC 29208 USA. [Holbrook, Joseph R.; Danielson, Melissa L.; Visser, Susanna N.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30340 USA. [Cuffe, Steven P.] Univ Florida, Coll Med, Jacksonville, FL USA. [Wolraich, Mark L.] Univ Oklahoma, Hlth Sci Ctr, OU Child Study Ctr, Oklahoma City, OK USA. RP Visser, SN (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, E-88,1600 Clifton Rd, Atlanta, GA 30340 USA. EM svisser@cdc.gov OI Danielson, Melissa/0000-0001-9461-0341 FU CDC [U50/CCU622315-02, U84/CCU422516-02, 200-200618912, 200-2006-18949] FX This article was supported by the CDC through cooperative agreements U50/CCU622315-02 and U84/CCU422516-02 and contracts 200-200618912 and 200-2006-18949. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 38 TC 5 Z9 5 U1 1 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0890-8567 EI 1527-5418 J9 J AM ACAD CHILD PSY JI J. Am. Acad. Child Adolesc. Psychiatr. PD JAN PY 2015 VL 54 IS 1 BP 53 EP 61 DI 10.1016/j.jaac.2014.10.014 PG 9 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA AX3DJ UT WOS:000346820400008 PM 25524790 ER PT J AU Peterson, C Grosse, SD Li, R Sharma, AJ Razzaghi, H Herman, WH Gilboa, SM AF Peterson, Cora Grosse, Scott D. Li, Rui Sharma, Andrea J. Razzaghi, Hilda Herman, William H. Gilboa, Suzanne M. TI Preventable health and cost burden of adverse birth outcomes associated with pregestational diabetes in the United States SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE diabetes mellitus; economic analysis; pregnancy complications ID FACTOR SURVEILLANCE SYSTEM; POPULATION-BASED COHORT; PRECONCEPTION CARE; CONGENITAL-ANOMALIES; RESOURCE UTILIZATION; REPRODUCTIVE AGE; ECONOMIC COSTS; WOMEN; PREGNANCY; TYPE-1 AB OBJECTIVE: Preconception care for women with diabetes can reduce the occurrence of adverse birth outcomes. We aimed to estimate the preconception care (PCC)epreventable health and cost burden of adverse birth outcomes associated with diagnosed and undiagnosed pregestational diabetes mellitus (PGDM) in the United States. STUDY DESIGN: Among women of reproductive age (15-44 years), we estimated age-and race/ethnicity-specific prevalence of diagnosed and undiagnosed diabetes. We applied age and race/ethnicity-specific pregnancy rates, estimates of the risk reduction from PCC for 3 adverse birth outcomes (preterm birth, major birth defects, and perinatal mortality), and lifetime medical and lost productivity costs for children with those outcomes. Using a probabilistic model, we estimated the reduction in adverse birth outcomes and costs associated with universal PCC compared with no PCC among women with PGDM. We did not assess maternal outcomes and associated costs. RESULTS: We estimated 2.2% of US births are to women with PGDM. Among women with diagnosed diabetes, universal PCC might avert 8397 (90% prediction interval [PI], 5252-11,449) preterm deliveries, 3725 (90% PI, 3259-4126) birth defects, and 1872 (90% PI, 1239-2415) perinatal deaths annually. Associated discounted lifetime costs averted for the affected cohort of children could be as high as $4.3 billion (90% PI, 3.4-5.1 billion) (2012 US dollars). PCC among women with undiagnosed diabetes could yield an additional $1.2 billion (90% PI, 951 million-1.4 billion) in averted cost. CONCLUSION: Results suggest a substantial health and cost burden associated with PGDM that could be prevented by universal PCC, which might offset the cost of providing such care. C1 [Peterson, Cora; Grosse, Scott D.; Razzaghi, Hilda; Gilboa, Suzanne M.] CDC, Natl Ctr Birth Defects & Dev Disabil, Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Li, Rui; Sharma, Andrea J.] CDC, Natl Ctr Chron Dis Prevent & Hlth Promot, Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Sharma, Andrea J.] US Public Hlth Serv Commissioned Corps, Atlanta, GA USA. [Razzaghi, Hilda] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Herman, William H.] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI USA. [Herman, William H.] Univ Michigan, Sch Med, Dept Epidemiol, Ann Arbor, MI USA. RP Peterson, C (reprint author), CDC, Natl Ctr Injury Prevent & Control, Atlanta, GA 30333 USA. EM cora.peterson@cdc.hhs.gov OI Peterson, Cora/0000-0001-7955-0977; Sharma, Andrea/0000-0003-0385-0011 FU Intramural CDC HHS [CC999999]; NIDDK NIH HHS [P30 DK020572, P30 DK092926] NR 57 TC 6 Z9 6 U1 1 U2 8 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JAN PY 2015 VL 212 IS 1 AR 74.e1 DI 10.1016/j.ajog.2014.09.009 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AW9OA UT WOS:000346585700024 PM 25439811 ER PT J AU Wilcox, S McClenaghan, B Sharpe, PA Baruth, M Hootman, JM Leith, K Dowda, M AF Wilcox, Sara McClenaghan, Bruce Sharpe, Patricia A. Baruth, Meghan Hootman, Jennifer M. Leith, Katherine Dowda, Marsha TI The Steps to Health Randomized Trial for Arthritis A Self-Directed Exercise Versus Nutrition Control Program SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID PHYSICAL-ACTIVITY INTERVENTIONS; RESIDING OLDER-ADULTS; KNEE OSTEOARTHRITIS; RHEUMATOID-ARTHRITIS; AFRICAN-AMERICANS; BODY-WEIGHT; WALK TEST; PAIN; ASSOCIATION; OUTCOMES AB Background: Despite the established benefits of exercise for adults with arthritis, participation is low. Safe, evidence-based, self-directed programs, which have the potential for high reach at a low cost, are needed. Purpose: To test a 12-week, self-directed, multicomponent exercise program for adults with arthritis. Design: Randomized controlled trial. Data were collected from 2010 to 2012. Data were analyzed in 2013 and 2014. Setting/participants: Adults with arthritis (N = 401, aged 56.3 [10.7] years, 85.8% women, 63.8% white, 35.2% African American, BMI of 33.0 [8.2]) completed measures at a university research center and participated in a self-directed exercise intervention (First Step to Active Health s) or nutrition control program (Steps to Healthy Eating). Intervention: Intervention participants received a self-directed multicomponent exercise program and returned self-monitoring logs for 12 weeks. Main outcome measures: Self-reported physical activity, functional performance measures, and disease-specific outcomes (arthritis symptoms and self-efficacy) assessed at baseline, 12 weeks, and 9 months. Results: Participants in the exercise condition showed greater increases in physical activity than those in the nutrition control group (p = 0.01). Significant improvements, irrespective of condition, were seen in lower body strength, functional exercise capacity, lower body flexibility, pain, fatigue, stiffness, and arthritis management self-efficacy (p values<0.0001). More adverse events occurred in the exercise than nutrition control condition, but only one was severe and most were expected with increased physical activity. Conclusions: The exercise program improves physical activity, and both programs improve functional and psychosocial outcomes. Potential reasons for improvements in the nutrition control condition are discussed. These interventions have the potential for large-scale dissemination. This study is registered at Clinicaltrials.gov NCT01172327. (C) 2015 American Journal of Preventive Medicine. All rights reserved. C1 [Wilcox, Sara; McClenaghan, Bruce; Sharpe, Patricia A.; Dowda, Marsha] Univ S Carolina, Dept Exercise Sci, Columbia, SC 29208 USA. [Wilcox, Sara; Sharpe, Patricia A.] Univ S Carolina, Prevent Res Ctr, Columbia, SC 29208 USA. [Leith, Katherine] Univ S Carolina, Coll Social Work, Columbia, SC 29208 USA. [Baruth, Meghan] Saginaw Valley State Univ, Dept Hlth Sci, University Ctr, MI USA. [Hootman, Jennifer M.] CDC, Div Populat Hlth, Atlanta, GA 30333 USA. RP Wilcox, S (reprint author), Univ S Carolina, Prevent Res Ctr, 921 Assembly St,PHRC 1st Floor, Columbia, SC 29208 USA. EM swilcox@sc.edu FU CDC's National Center for Chronic Disease Prevention and Health Promotion [U48-DP-001936, 09-028] FX This work was supported by CDC's National Center for Chronic Disease Prevention and Health Promotion by Cooperative Agreement No. U48-DP-001936, Special Interest Project (SIP) 09-028. A portion of Sara Wilcox's, Bruce McClenaghan's, Patricia A. Sharpe's, Meghan Baruth's, Katherine Leith's, and Marsha Dowda's salaries were supported by a Cooperative Agreement (No. U48-DP-001936, Special Interest Project 09-028) from CDC's National Center for Chronic Disease Prevention and Health Promotion. Jennifer Hootman from CDC was involved in the initial study design and writing the manuscript, and contributed to the decision to submit the manuscript for publication. NR 44 TC 3 Z9 3 U1 1 U2 16 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2015 VL 48 IS 1 BP 1 EP 12 DI 10.1016/j.amepre.2014.08.006 PG 12 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AW7CQ UT WOS:000346422600001 PM 25441237 ER PT J AU Khalil, GM Crawford, CAG AF Khalil, George M. Crawford, Carol A. Gotway TI A Bibliometric Analysis of US-Based Research on the Behavioral Risk Factor Surveillance System SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID TRENDS AB Background: Since Alan Pritchard defined bibliometrics as "the application of statistical methods to media of communication" in 1969, bibliometric analyses have become widespread. To date, however, bibliometrics has not been used to analyze publications related to the U.S. Behavioral Risk Factor Surveillance System (BRFSS). Purpose: To determine the most frequently cited BRFSS-related topical areas, institutions, and journals. Methods: A search of the Web of Knowledge database in 2013 identified U.S.-published studies related to BRFSS, from its start in 1984 through 2012. Search terms were BRFSS, Behavioral Risk Factor Surveillance System, or Behavioral Risk Survey. The resulting 1,387 articles were analyzed descriptively and produced data for VOSviewer, a computer program that plotted a relevance distance-based map and clustered keywords from text in titles and abstracts. Results: Topics, journals, and publishing institutions ranged widely. Most research was clustered by content area, such as cancer screening, access to care, heart health, and quality of life. The American Journal of Preventive Medicine and American Journal of Public Health published the most BRFSS-related papers (95 and 70, respectively). Conclusions: Bibliometrics can help identify the most frequently published BRFSS-related topics, publishing journals, and publishing institutions. BRFSS data are widely used, particularly by CDC and academic institutions such as the University of Washington and other universities hosting top-ranked schools of public health. Bibliometric analysis and mapping provides an innovative way of quantifying and visualizing the plethora of research conducted using BRFSS data and summarizing the contribution of this surveillance system to public health. (C) 2015 American Journal of Preventive Medicine. All rights reserved. C1 [Khalil, George M.] CDC, Northrop Grumman Informat Syst, Atlanta, GA USA. [Crawford, Carol A. Gotway] CDC, Populat Hlth Surveillance Branch, Div Populat Hlth, Atlanta, GA USA. RP Khalil, GM (reprint author), Northrop Grumman Corp, 1600 Clifton Rd NE,MS 83, Atlanta, GA 30333 USA. EM uwm4@cdc.gov OI Khalil, George/0000-0002-5878-3445 FU CDC's Behavioral Risk Factor Surveillance System FX Although the authors do not believe the results of this analysis were in any way influenced by conflicting interests, they would like to report that they are supported by CDC's Behavioral Risk Factor Surveillance System. NR 11 TC 1 Z9 2 U1 1 U2 19 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2015 VL 48 IS 1 BP 50 EP 57 DI 10.1016/j.amepre.2014.08.021 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AW7CQ UT WOS:000346422600006 PM 25442231 ER PT J AU Yang, QH Zhong, YN Ritchey, M Loustalot, F Hong, YL Merritt, R Bowman, BA AF Yang, Quanhe Zhong, Yuna Ritchey, Matthew Loustalot, Fleetwood Hong, Yuling Merritt, Robert Bowman, Barbara A. TI Predicted 10-Year Risk of Developing Cardiovascular Disease at the State Level in the US SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID NUTRITION EXAMINATION SURVEY; AMERICAN-HEART-ASSOCIATION; FACTOR SURVEILLANCE SYSTEM; UNITED-STATES; CIGARETTE-SMOKING; NATIONAL-HEALTH; PHYSICAL-ACTIVITY; PREVALENCE; ADULTS; TRENDS AB Background: Cardiovascular disease (CVD) is the leading cause of death in the U.S. State-specific predicted 10-year risk of developing CVD could provide useful information for state health planning and policy. Purpose: To estimate state-specific 10-year risk of developing CVD. Methods: Using the updated non-laboratory-based Framingham CVD Risk Score (RS), this study estimated 10-year risk of developing CVD; coronary heart disease (CHD); and stroke, stratified by demographic factors and by state among 2009 Behavioral Risk Factors Surveillance System participants aged 30-74 years. Data analysis was completed in June 2014. Results: The age-standardized mean CVD, CHD, and stroke RSs for adults aged 30-74 years were 14.6%, 10.4%, and 2.3% among men, respectively, and 7.5%, 4.5%, and 1.8% among women. RSs increased significantly with age and were highest among non-Hispanic blacks, those with less than high school education, and households with incomes <$35,000. State-specific age-standardized CVD, CHD, and stroke RS ranged, among men, from lows in Utah (13.2%, 9.6%, and 2.1%, respectively) to highs in Louisiana (16.2%, 11.7%, and 2.6%), and among women, from lows in Minnesota (6.3%, 3.8%, and 1.5%) to highs in Mississippi (8.7%, 5.3%, and 2.1%). Conclusions: The predicted 10-year risk of developing CVD varies significantly by age, gender, race/ethnicity, educational attainment, household income, and state of residence. These results support the development and implementation of targeted prevention programs by states to address the risk of developing CVD, CHD, and stroke among their populations. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine. C1 [Yang, Quanhe; Zhong, Yuna; Ritchey, Matthew; Loustalot, Fleetwood; Hong, Yuling; Merritt, Robert; Bowman, Barbara A.] CDC, Div Heart Dis & Stroke Prevent, Atlanta, GA 30341 USA. RP Yang, QH (reprint author), CDC, Div Heart Dis & Stroke Prevent, 4770 Buford HWY,MailStop F-72, Atlanta, GA 30341 USA. EM qay0@cdc.gov NR 47 TC 4 Z9 4 U1 1 U2 11 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2015 VL 48 IS 1 BP 58 EP 69 DI 10.1016/j.amepre.2014.09.014 PG 12 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AW7CQ UT WOS:000346422600007 PM 25450016 ER PT J AU Fallin, A Goodin, AJ King, BA AF Fallin, Amanda Goodin, Amie J. King, Brian A. TI Menthol Cigarette Smoking among Lesbian, Gay, Bisexual, and Transgender Adults SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID UNITED-STATES; TOBACCO USE AB Background: Menthol can mask the harshness and taste of tobacco, making menthol cigarettes easier to use and increasing their appeal among vulnerable populations. The tobacco industry has targeted youth, women, and racial minorities with menthol cigarettes, and these groups smoke menthol cigarettes at higher rates. The tobacco industry has also targeted the lesbian, gay, bisexual, and transgender (LGBT) communities with tobacco product marketing. Purpose: To assess current menthol cigarette smoking by sexual orientation among a nationally representative sample of U.S. adults. Methods: Data were obtained from the 2009-2010 National Adult Tobacco Survey, a national landline and cellular telephone survey of non-institutionalized U.S. adults aged >= 18 years, to compare current menthol cigarette smoking between LGBT (n=2,431) and heterosexual/straight (n=110,841) adults. Data were analyzed during January-April 2014 using descriptive statistics and logistic regression adjusted for sex, age, race, and educational attainment. Results: Among all current cigarette smokers, 29.6% reported usually smoking menthol cigarettes in the past 30 days. Menthol use was significantly higher among LGBT smokers, with 36.3% reporting that the cigarettes they usually smoked were menthol compared to 29.3% of heterosexual/straight smokers (p<0.05); this difference was particularly prominent among LGBT females (42.9%) compared to heterosexual/straight women (32.4%) (p<0.05). Following adjustment, LGBT smokers had greater odds of usually smoking menthol cigarettes than heterosexual/straight smokers (OR=1.31, 95% CI=1.09, 1.57). Conclusions: These findings suggest that efforts to reduce menthol cigarette use may have the potential to reduce tobacco use and tobacco-related disease and death among LGBT adults. (C) 2015 American Journal of Preventive Medicine. All rights reserved. C1 [Fallin, Amanda] Univ Calif San Francisco, Ctr Tobacco Control Res & Educ, San Francisco, CA 94143 USA. [Goodin, Amie J.] Univ Kentucky, Inst Pharmaceut Outcomes & Policy, Lexington, KY 40536 USA. [King, Brian A.] CDC, Off Smoking & Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. RP Fallin, A (reprint author), Univ Kentucky, Coll Nursing, Lexington, KY 40536 USA. EM atfall2@uky.edu FU Intramural CDC HHS [CC999999] NR 15 TC 5 Z9 5 U1 0 U2 12 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 EI 1873-2607 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2015 VL 48 IS 1 BP 93 EP 97 DI 10.1016/j.amepre.2014.07.044 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AW7CQ UT WOS:000346422600011 PM 25245795 ER PT J AU Loeb, M Jonas, BS AF Loeb, Mitchell Jonas, Bruce S. TI Psychological and physical functioning difficulties associated with complex activity limitations among US adults SO DISABILITY AND HEALTH JOURNAL LA English DT Article DE Psychological functioning; Physical functioning; Basic actions difficulty; Complex activity limitations; K-6 ID MAJOR DEPRESSIVE-DISORDERS; SUBSYNDROMAL DEPRESSION; CLINICAL-SIGNIFICANCE; GENERAL-POPULATION; DISABILITY; HEALTH; ILLNESS; ANXIETY; BURDEN; WORK AB Background: There is limited research that assesses psychological functioning categorically as a predictor of complex activity limitations either alone or in conjunction with physical functioning. Objectives: This paper assesses the impact of psychological and/or physical functioning difficulties as predictors of complex activity limitations among U.S. adults, using data from a national survey. Methods: Data come from the 2006-2010 National Health Interview Survey among U.S. adults 18 or older (n = 124,337). We developed a combined physical/psychological exposure variable with six categories: 1) no/low psychological distress (LPD) and absence of physical functioning difficulties, 2) moderate psychological distress (MPD) only, 3) serious psychological distress (SPD) only, 4) physical functioning difficulty only, 5) MPD and physical functioning difficulties, and 6) SPD and physical functioning difficulties. Selected complex activity limitations include daily living, social and work limitations. Results: Compared to adults with LPD and absence of physical functioning difficulties, the results demonstrated a clear and significant gradient of increasing risk of complex activity limitations beginning with MPD only, SPD only, physical functioning difficulty only, both MPD and physical functioning difficulties, and SPD and physical functioning difficulties. Conclusions: The data suggest a stronger risk of complex activity limitations when increasing psychological functioning difficulties coexist with physical functioning difficulties, leading to potential interference with a person's ability to accomplish major life activities measured in this study. The sizeable contribution of psychological distress to the prevalence of basic actions difficulty implies that the mental health component of functional limitations is important in the overall assessment of health and well-being. Published by Elsevier Inc. C1 [Loeb, Mitchell; Jonas, Bruce S.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. RP Loeb, M (reprint author), Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, 3311 Toledo Rd, Hyattsville, MD 20782 USA. EM mloeb@cdc.gov FU Intramural CDC HHS [CC999999] NR 45 TC 2 Z9 2 U1 6 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1936-6574 EI 1876-7583 J9 DISABIL HEALTH J JI Disabil. Health J. PD JAN PY 2015 VL 8 IS 1 BP 70 EP 79 DI 10.1016/j.dhjo.2014.08.003 PG 10 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health; Rehabilitation SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Rehabilitation GA AW2YZ UT WOS:000346153800010 PM 25239646 ER PT J AU Schuchter, J Rutt, C Satariano, WA Seto, E AF Schuchter, Joseph Rutt, Candace Satariano, William A. Seto, Edmund TI Building capacity for Health Impact Assessment: Training outcomes from the United States SO ENVIRONMENTAL IMPACT ASSESSMENT REVIEW LA English DT Article DE Health Impact Assessment; Capacity-building; Training; Evaluation ID PUBLIC-HEALTH; WORKFORCE DEVELOPMENT; DECISION-MAKING; POLICY; ENVIRONMENT AB Background: Despite the continued growth of Health Impact Assessment (HIA) in the US, there is little research on HIA capacity-building. A comprehensive study of longer-term training outcomes may reveal opportunities for improving capacity building activities and HIA practice. Methods: We conducted in-depth interviews with HIA trainees in-the United States to assess their outcomes and needs. Using a training evaluation framework, we measured outcomes across a spectrum of reaction, learning, behavior and results. Results: From 2006 to 2012, four organizations trained over 2200 people in at least 75 in-person HIA trainings in 29 states. We interviewed 48 trainees, selected both randomly and purposefully. The mean duration between training and interview was 3.4 years. Trainees reported that their training objectives were met, especially when relevant case-studies were used. They established new collaborations at the trainings and maintained them. Training appeared to catalyze more holistic thinking and practice, including a range of HIA-related activities. Many trainees disseminated what they learned and engaged in components of HIA, even without dedicated funding. Going forward, trainees need assistance with quantitative methods, project management, community engagement, framing recommendations, and evaluation. Conclusions: The research revealed opportunities fora range of HIA stakeholders to refine and coordinate training resources, apply a competency framework and leverage complimentary workforce development efforts, and sensitize and build the capacity of communities. Published by Elsevier Inc. C1 [Rutt, Candace] Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, Atlanta, GA 30341 USA. [Satariano, William A.] Univ Calif Berkeley, Sch Publ Hlth, Div Community Hlth & Human Dev, Berkeley, CA 94720 USA. [Seto, Edmund] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA. RP Rutt, C (reprint author), Ctr Dis Control & Prevent, Div Nutr Phys Act & Obes, 4770 Buford Highway MS-F-77, Atlanta, GA 30341 USA. EM awr8@cdc.gov NR 45 TC 0 Z9 0 U1 2 U2 13 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0195-9255 EI 1873-6432 J9 ENVIRON IMPACT ASSES JI Environ. Impact Assess. Rev. PD JAN PY 2015 VL 50 BP 190 EP 195 DI 10.1016/j.eiar.2014.10.002 PG 6 WC Environmental Studies SC Environmental Sciences & Ecology GA AW3WW UT WOS:000346214900020 ER PT J AU Yoon, SS Gu, QP Nwankwo, T Wright, JD Hong, YL Burt, V AF Yoon, Sung Sug Gu, Qiuping Nwankwo, Tatiana Wright, Jacqueline D. Hong, Yuling Burt, Vicki TI Trends in Blood Pressure Among Adults With Hypertension United States, 2003 to 2012 SO HYPERTENSION LA English DT Article DE blood pressure; epidemiology; hypertension; prevention and control; therapeutics ID TREATMENT-RESISTANT HYPERTENSION; CORONARY-HEART-DISEASE; LIFE-STYLE; PREVALENCE; AWARENESS; STROKE; TRIAL; US AB The aim of this study is to describe trends in the awareness, treatment, and control of hypertension; mean blood pressure; and the classification of blood pressure among US adults 2003 to 2012. Using data from the National Health and Nutrition Examination Survey 2003 to 2012, a total of 9255 adult participants aged >= 18 years were identified as having hypertension, defined as measured blood pressure >= 140/90 mm Hg or taking prescription medication for hypertension. Awareness and treatment among hypertensive adults were ascertained via an interviewer administered questionnaire. Controlled hypertension among hypertensive adults was defined as systolic blood pressure <140 mm Hg and diastolic blood pressure <90 mm Hg. Blood pressure was categorized as optimal blood pressure, prehypertension, and stage I and stage II hypertension. Between 2003 and 2012, the percentage of adults with controlled hypertension increased (P-trend <0.01). Hypertensive adults with optimal blood pressure and with prehypertension increased from 13% to 19% and 27% to 33%, respectively (P-trend <0.01 for both groups). Among hypertensive adults who were taking antihypertensive medication, uncontrolled hypertension decreased from 38% to 30% (P-trend <0.01). Similarly, a decrease in mean systolic blood pressure was observed (P-trend <0.01); however, mean diastolic blood pressure remained unchanged. The trend in the control of blood pressure has improved among hypertensive adults resulting in a higher percentage with blood pressure at the optimal or prehypertension level and a lower percentage in stage I and stage II hypertension. Overall, mean systolic blood pressure decreased as did the prevalence of uncontrolled hypertension among the treated hypertensive population. C1 [Yoon, Sung Sug; Gu, Qiuping; Nwankwo, Tatiana; Burt, Vicki] Ctr Dis Control & Prevent, Div Hlth & Nutr Examinat Surveys, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Wright, Jacqueline D.] NHLBI, Epidemiol Branch, Program Prevent & Populat Sci, Div Cardiovasc Sci,NIH, Bethesda, MD 20892 USA. [Hong, Yuling] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Yoon, SS (reprint author), Ctr Dis Control & Prevent, Div Hlth & Nutr Examinat Surveys, Natl Ctr Hlth Stat, 3311 Toledo Rd,Rm, Hyattsville, MD 20782 USA. EM syoon1@cdc.gov NR 23 TC 34 Z9 34 U1 3 U2 21 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0194-911X EI 1524-4563 J9 HYPERTENSION JI Hypertension PD JAN PY 2015 VL 65 IS 1 BP 54 EP + DI 10.1161/HYPERTENSIONAHA.114.04012 PG 11 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA AW4KA UT WOS:000346248800016 PM 25399687 ER PT J AU Stephenson, MR Stephenson, CM AF Stephenson, Mark R. Stephenson, Carol Merry TI Commentary on (1) 'Application of the health belief model: Development of the hearing beliefs questionnaire (HBQ) and its associations with hearing health behaviors' (International Journal of Audiology, 2013; 52, 558-567), and (2) 'Development and evaluation of a questionnaire to assess knowledge, attitudes, and behaviors towards hearing loss prevention' (International Journal of Audiology, 2014; 53, 209-218). SO INTERNATIONAL JOURNAL OF AUDIOLOGY LA English DT Letter ID PROMOTION MODEL; PROTECTION USE; WORKERS USE C1 [Stephenson, Mark R.; Stephenson, Carol Merry] NIOSH, Cincinnati, OH 45226 USA. RP Stephenson, MR (reprint author), NIOSH, Cincinnati, OH 45226 USA. NR 31 TC 0 Z9 0 U1 1 U2 9 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1499-2027 EI 1708-8186 J9 INT J AUDIOL JI Int. J. Audiol. PD JAN PY 2015 VL 54 IS 1 BP 58 EP 60 DI 10.3109/14992027.2014.966923 PG 3 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA AW7TX UT WOS:000346468200007 PM 25470621 ER PT J AU Champaloux, SW Young, DR AF Champaloux, Steven W. Young, Deborah R. TI Childhood Chronic Health Conditions and Educational Attainment: A Social Ecological Approach SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Chronic health conditions; Educational attainment; Social ecological approach ID ADOLESCENT DEPRESSION; MENTAL-HEALTH; OUTCOMES; ILLNESS; ASTHMA; MHI-5 AB Purpose: This study examined the association between types of chronic health conditions reported during childhood and adolescence and their impact on educational attainment. School and neighborhood environments and potential mediating factors from academic and psychosocial variables were investigated. Methods: Using the National Longitudinal Survey of Youth Cohort 1997, multivariate logistic regression models were fit to estimate the association between chronic health conditions and educational attainment, adjusting for confounders. Chronic health conditions were defined as a parental (1997) or participant (2002) report of a chronic health condition and classified into (1) asthma; (2) cancer, diabetes, and epilepsy; (3) heart conditions; and (4) other. Educational attainment was defined as receiving a high school diploma or Graduate Equivalency Degree by age 21, determined from self-report. Results: Youth who reported having a chronic health condition had higher odds of low educational attainment compared with youth who did not report a condition (n = 6,795; odds ratio [OR], 1.47; 95% confidence interval [CI], 1.22-1.76). Specifically, youth with asthma (OR, 1.63; 95% CI, 1.31-2.02) and those with cancer, diabetes, or epilepsy (OR, 1.96; 95% CI, 1.13-3.37) had higher odds of low attainment. For youth who reported cancer, diabetes, or epilepsy, the variables "school absences," "repeated a grade," and "depressive symptoms" attenuated the association and were considered mediators. Conclusions: Youth with chronic health conditions had lower educational attainment. Students with cancer, diabetes, or epilepsy who had a high number of absences, had repeated a grade, or had a high-depressive symptoms score were particularly impacted. (C) 2015 Society for Adolescent Health and Medicine. All rights reserved. C1 [Champaloux, Steven W.] Univ Maryland, Sch Publ Hlth, Dept Epidemiol & Biostat, College Pk, MD 20742 USA. [Young, Deborah R.] Kaiser Permanente So Calif, Dept Res & Evaluat, Pasadena, CA 91101 USA. RP Champaloux, SW (reprint author), Ctr Dis Control & Prevent, Womens Hlth & Fertil Branch, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, 4770 Buford Highway, Atlanta, GA 30341 USA. EM SChampaloux@cdc.gov NR 38 TC 6 Z9 6 U1 2 U2 23 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD JAN PY 2015 VL 56 IS 1 BP 98 EP 105 DI 10.1016/j.jadohealth.2014.07.016 PG 8 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA AW9OM UT WOS:000346586900017 PM 25305800 ER PT J AU Foshee, VA Reyes, LM Tharp, AT Chang, LY Ennett, ST Simon, TR Latzman, NE Suchindran, C AF Foshee, Vangie A. Reyes, Luz McNaughton Tharp, Andra T. Chang, Ling-Yin Ennett, Susan T. Simon, Thomas R. Latzman, Natasha E. Suchindran, Chiravath TI Shared Longitudinal Predictors of Physical Peer and Dating Violence SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE Adolescent violence prevention; Peer violence; Dating violence ID HEALTH-RISK BEHAVIORS; PREVENTION PROGRAM; PROTECTIVE FACTORS; RANDOMIZED-TRIAL; ADOLESCENTS; YOUTH; PERPETRATION; AGGRESSION; DELINQUENCY; FAMILY AB Purpose: Peers and dates are common targets of adolescent violence. Prevention programs typically address either peer violence (PV) or dating violence (DV) but not both. However, if PV and DV share predictors, prevention strategies could target both behaviors, yielding economic and time efficiencies. Longitudinal data were examined to determine the extent to which physical PV and DV shared predictors. Guided by social learning and social control theories, both risk and protective factors were examined at multiple levels of the social ecology. Methods: Adolescents in the eighth through 10th grades in three North Carolina counties completed self-administered questionnaires in school in the fall 2003 (Wave 1) and again in spring 2004 (Wave 2) (n = 4,227). The sample was 48% male; 55% white, 33% black, and 12% of other race/ ethnicity. A generalized estimating equations approach used adjusted standard errors to account for the correlation between the two violence outcomes. Results: For both boys and girls, anger, family conflict, and having models of deviant behavior in the school were shared risk factors, and holding prosocial beliefs was a shared protective factor. For girls, anxiety and having models of deviant behavior in the neighborhood were additional shared risk factors. For boys, heavy alcohol use was an additional shared risk factor and parental monitoring was an additional shared protective factor. Conclusions: Findings can inform the development of comprehensive cross-cutting prevention strategies at multiple levels of the social ecology designed to prevent both types of violence. (C) 2015 Society for Adolescent Health and Medicine. All rights reserved. C1 [Foshee, Vangie A.; Reyes, Luz McNaughton; Chang, Ling-Yin; Ennett, Susan T.] Univ N Carolina, Dept Hlth Behav, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. [Tharp, Andra T.; Simon, Thomas R.; Latzman, Natasha E.] Ctr Dis Control & Prevent, Div Violence Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. [Suchindran, Chiravath] Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA. RP Foshee, VA (reprint author), Univ N Carolina, Dept Hlth Behav, Gillings Sch Global Publ Hlth, 319B Rosenau Hall, Chapel Hill, NC 27599 USA. EM foshee@email.unc.edu FU National Institute on Drug Abuse [R01 DA13459]; Centers for Disease Control and Prevention (CDC) [R49 CCV423114]; CDC [13IPA1303570, 13IPA130569] FX This research was funded by the National Institute on Drug Abuse (R01 DA13459), the Centers for Disease Control and Prevention (CDC) (R49 CCV423114), and an intergovernmental personnel agreement between Dr. Foshee and the CDC (13IPA1303570) and between Dr. McNaughton Reyes and the CDC (13IPA130569). NR 40 TC 6 Z9 7 U1 2 U2 28 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X EI 1879-1972 J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD JAN PY 2015 VL 56 IS 1 BP 106 EP 112 DI 10.1016/j.jadohealth.2014.08.003 PG 7 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA AW9OM UT WOS:000346586900018 PM 25287983 ER PT J AU Patriarca, M Weykamp, C Arnaud, J Jones, RL Parsons, PJ Taylor, A AF Patriarca, Marina Weykamp, Cas Arnaud, Josiane Jones, Robert L. Parsons, Patrick J. Taylor, Andrew TI Traceable assigned values in external quality assessment schemes compared to those obtained by alternative procedure: a case study for Cu, Se and Zn in serum SO JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY LA English DT Article AB International standards for the recognition of the competence of testing laboratories require that measurement results should be traceable to a conventionally agreed reference. This should be achieved by appropriate calibration of equipment and method validation involving analysis of certified reference materials (CRM). However, these are costly and for many analytical procedures, few are available. Participation in external quality assessment schemes (EQAS) may provide a mean to support the laboratory traceability statement, if the values assigned to test samples are traceable to a stated reference. Values may be assigned to EQAS test samples by a variety of techniques but there has been no direct comparison of results obtained when these procedures are applied to the same samples. In this study, traceable values for Cu, Se and Zn concentrations were assigned to three batches of EQAS serum samples, by analysis by expert laboratories together with CRMs, and compared with those obtained by three other of the approaches described in ISO 13528; analysis by a definitive method (ID-ICP-MS); determination of robust consensus mean from the results of expert laboratories; robust consensus mean of results from EQAS participants. The assigned values (mu mol L-1) +/- expanded uncertainty (%) for the low, medium and high pools obtained by ID-ICP-MS were: Cu 13.37 +/- 1.2, 21.03 +/- 1.8, 28.73 +/- 1.2; Se 0.74 +/- 3.5, 1.51 +/- 3.4, 3.11 +/- 3.6; Zn 9.69 +/- 4.9, 22.52 +/- 1.5, 30.85 +/- 3.8. Concentrations determined using the three other approaches were similar but the uncertainties increased as the methodologies became increasingly less rigorous. C1 [Patriarca, Marina] Ist Super Sanita, Dept Food Safety & Publ Vet Hlth, I-00161 Rome, Italy. [Weykamp, Cas] Queen Beatrix Hosp, MCA Lab, NL-7101 BN Winterswijk, Netherlands. [Arnaud, Josiane] Univ Hosp Grenoble, Inst Biol & Pathol, Dept Biochem Pharmacol & Toxicol, F-38043 Grenoble 9, France. [Jones, Robert L.] CDC, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA. [Parsons, Patrick J.] New York State Dept Hlth, Lab Inorgan & Nucl Chem, Wadsworth Ctr, Albany, NY 12201 USA. [Parsons, Patrick J.] SUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Albany, NY 12201 USA. [Taylor, Andrew] Royal Surrey Cty Hosp, Dept Clin Biochem, SAS Trace Element Ctr, Guildford GU2 7XX, Surrey, England. RP Taylor, A (reprint author), Royal Surrey Cty Hosp, Dept Clin Biochem, SAS Trace Element Ctr, 15 Frederick Sanger Rd, Guildford GU2 7XX, Surrey, England. EM andrewtaylor4@nhs.net RI PATRIARCA, MARINA/E-3680-2015; OI Parsons, Patrick/0000-0001-9133-875X NR 13 TC 1 Z9 1 U1 0 U2 3 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 0267-9477 EI 1364-5544 J9 J ANAL ATOM SPECTROM JI J. Anal. At. Spectrom. PY 2015 VL 30 IS 1 BP 148 EP 153 DI 10.1039/c4ja00260a PG 6 WC Chemistry, Analytical; Spectroscopy SC Chemistry; Spectroscopy GA AW4LE UT WOS:000346251800009 ER PT J AU Arita, M Kilpatrick, DR Nakamura, T Burns, CC Bukbuk, D Oderinde, SB Oberste, MS Kew, OM Pallansch, MA Shimizu, H AF Arita, Minetaro Kilpatrick, David R. Nakamura, Tomofumi Burns, Cara C. Bukbuk, David Oderinde, Soji B. Oberste, M. Steven Kew, Olen M. Pallansch, Mark A. Shimizu, Hiroyuki TI Development of an Efficient Entire-Capsid-Coding-Region Amplification Method for Direct Detection of Poliovirus from Stool Extracts SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID DEOXYINOSINE RESIDUES; CODON DEGENERACY; MIXED-BASE; RT-PCR; IDENTIFICATION; PRIMERS; SEROTYPE; POSITIONS AB Laboratory diagnosis has played a critical role in the Global Polio Eradication Initiative since 1988, by isolating and identifying poliovirus (PV) from stool specimens by using cell culture as a highly sensitive system to detect PV. In the present study, we aimed to develop a molecular method to detect PV directly from stool extracts, with a high efficiency comparable to that of cell culture. We developed a method to efficiently amplify the entire capsid coding region of human enteroviruses (EVs) including PV. cDNAs of the entire capsid coding region (3.9 kb) were obtained from as few as 50 copies of PV genomes. PV was detected from the cDNAs with an improved PV-specific real-time reverse transcription-PCR system and nucleotide sequence analysis of the VP1 coding region. For assay validation, we analyzed 84 stool extracts that were positive for PV in cell culture and detected PV genomes from 100% of the extracts (84/84 samples) with this method in combination with a PV-specific extraction method. PV could be detected in 2/4 stool extract samples that were negative for PV in cell culture. In PV-positive samples, EV species C viruses were also detected with high frequency (27% [23/86 samples]). This method would be useful for direct detection of PV from stool extracts without using cell culture. C1 [Arita, Minetaro; Nakamura, Tomofumi; Shimizu, Hiroyuki] Natl Inst Infect Dis, Dept Virol 2, Tokyo, Japan. [Kilpatrick, David R.; Burns, Cara C.; Oberste, M. Steven; Kew, Olen M.; Pallansch, Mark A.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. [Bukbuk, David; Oderinde, Soji B.] Univ Maiduguri, Teaching Hosp, WHO Natl Polio Lab, Maiduguri, Nigeria. RP Arita, M (reprint author), Natl Inst Infect Dis, Dept Virol 2, Tokyo, Japan. EM minetaro@nih.go.jp OI Bukbuk, David Nadeba/0000-0003-3388-3842; arita, minetaro/0000-0002-3314-6626 FU World Health Organization FX This report is based on research funded by a grant from the World Health Organization for a collaborative research project of the Global Polio Eradication Initiative. NR 13 TC 4 Z9 4 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2015 VL 53 IS 1 BP 73 EP 78 DI 10.1128/JCM.02384-14 PG 6 WC Microbiology SC Microbiology GA AW8HM UT WOS:000346502200013 PM 25339406 ER PT J AU Williams, MM Taylor, TH Warshauer, DM Martin, MD Valley, AM Tondella, ML AF Williams, Margaret M. Taylor, Thomas H., Jr. Warshauer, David M. Martin, Monte D. Valley, Ann M. Tondella, M. Lucia TI Harmonization of Bordetella pertussis Real-Time PCR Diagnostics in the United States in 2012 SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID SPECIMENS; OUTBREAKS; HOLMESII; ASSAY AB Real-time PCR (rt-PCR) is an important diagnostic tool for the identification of Bordetella pertussis, Bordetella holmesii, and Bordetella parapertussis. Most U.S. public health laboratories (USPHLs) target IS481, present in 218 to 238 copies in the B. pertussis genome and 32 to 65 copies in B. holmesii. The CDC developed a multitarget PCR assay to differentiate B. pertussis, B. holmesii, and B. parapertussis and provided protocols and training to 19 USPHLs. The 2012 performance exercise (PE) assessed the capability of USPHLs to detect these three Bordetella species in clinical samples. Laboratories were recruited by the Wisconsin State Proficiency Testing program through the Association of Public Health Laboratories, in partnership with the CDC. Spring and fall PE panels contained 12 samples each of viable Bordetella and non-Bordetella species in saline. Fifty and 53 USPHLs participated in the spring and fall PEs, respectively, using a variety of nucleic acid extraction methods, PCR platforms, and assays. Ninety-six percent and 94% of laboratories targeted IS481 in spring and fall, respectively, in either singleplex or multiplex assays. In spring and fall, respectively, 72% and 79% of USPHLs differentiated B. pertussis and B. holmesii and 68% and 72% identified B. parapertussis. IS481 cycle threshold (C-T) values for B. pertussis samples had coefficients of variation (CV) ranging from 10% to 28%. Of the USPHLs that differentiated B. pertussis and B. holmesii, sensitivity was 96% and specificity was 95% for the combined panels. The 2012 PE demonstrated increased harmonization of rt-PCR Bordetella diagnostic protocols in USPHLs compared to that of the previous survey. C1 [Williams, Margaret M.; Taylor, Thomas H., Jr.; Martin, Monte D.; Tondella, M. Lucia] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Warshauer, David M.; Valley, Ann M.] Univ Wisconsin, Wisconsin State Lab Hyg, Madison, WI 53706 USA. RP Williams, MM (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM mwilliams7@cdc.gov FU Association of Public Health Laboratories FX We thank the Association of Public Health Laboratories for providing funding for the 2012 testing panels. We also thank the participating laboratories. NR 15 TC 7 Z9 7 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2015 VL 53 IS 1 BP 118 EP 123 DI 10.1128/JCM.02368-14 PG 6 WC Microbiology SC Microbiology GA AW8HM UT WOS:000346502200019 PM 25355770 ER PT J AU Diaz, MH Benitez, AJ Winchell, JM AF Diaz, Maureen H. Benitez, Alvaro J. Winchell, Jonas M. TI Investigations of Mycoplasma pneumoniae Infections in the United States: Trends in Molecular Typing and Macrolide Resistance from 2006 to 2013 SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID COMMUNITY-ACQUIRED PNEUMONIA; TANDEM-REPEAT ANALYSIS; REAL-TIME PCR; RESOLUTION MELT ANALYSIS; RESPIRATORY ILLNESS; PEDIATRIC-PATIENTS; DISEASES-SOCIETY; STRAINS; EPIDEMIOLOGY; GUIDELINES AB Mycoplasma pneumoniae is a leading cause of respiratory infections, including community-acquired pneumonia (CAP). Currently, pathogen-specific testing is not routinely performed in the primary care setting, and the United States lacks a systematic surveillance program for M. pneumoniae. Documentation of individual cases and clusters typically occurs only when severe illness and/or failure to improve with empirical antibiotic therapy is observed. Outbreaks, some lasting for extended periods and involving a large number of cases, occur regularly. However, many more likely go unrecognized due to the lack of diagnostic testing and structured reporting. We reviewed data from 17 investigations of cases, small clusters, and outbreaks of M. pneumoniae infections that were supported by the Centers for Disease Control and Prevention (CDC) between 2006 and 2013. We examined 199 M. pneumoniae-positive specimens collected during this time period in order to identify trends in antimicrobial resistance and circulating types. Overall, macrolide resistance was identified in approximately 10% of M. pneumoniae infections occurring during this time period. Typing of strains revealed cocirculation of multiple multilocus variable-number tandem-repeat analysis (MLVA) and P1 types throughout this period, including diversity in types detected within individual outbreaks. Three MLVA types (4572, 3562, and 3662) accounted for 97% of the infections during the study period. A systematic surveillance program is necessary to understand the burden of M. pneumoniae disease in the United States, facilitate case and outbreak identification, and inform appropriate therapeutic and infection control strategies. C1 [Diaz, Maureen H.; Benitez, Alvaro J.; Winchell, Jonas M.] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30333 USA. RP Winchell, JM (reprint author), Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA 30333 USA. EM jwinchell@cdc.gov NR 32 TC 16 Z9 20 U1 1 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2015 VL 53 IS 1 BP 124 EP 130 DI 10.1128/JCM.02597-14 PG 7 WC Microbiology SC Microbiology GA AW8HM UT WOS:000346502200020 PM 25355769 ER PT J AU Deak, E Hindler, JA Skov, R Sjolund-Karlsson, M Sokovic, A Humphries, RM AF Deak, Eszter Hindler, Janet A. Skov, Robert Sjoelund-Karlsson, Maria Sokovic, Anita Humphries, Romney M. TI Performance of Etest and Disk Diffusion for Detection of Ciprofloxacin and Levofloxacin Resistance in Salmonella enterica SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID QUINOLONES AB We compared Etest and disk diffusion to broth microdilution for the detection of fluoroquinolone resistance in 135 typhoidal and nontyphoidal serovars of Salmonella. Categorical agreements for the ciprofloxacin and levofloxacin Etests were 89.6 and 83.7%, respectively. Disk diffusion categorical agreements were 88.2 and 93.3%, respectively. Only minor errors were observed. C1 [Deak, Eszter] Santa Clara Valley Med Ctr, Dept Pathol & Lab Med, San Jose, CA 95128 USA. [Hindler, Janet A.; Sokovic, Anita; Humphries, Romney M.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA. [Skov, Robert] Statens Serum Inst, DK-2300 Copenhagen, Denmark. [Sjoelund-Karlsson, Maria] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. RP Humphries, RM (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA. EM rhumphries@mednet.ucla.edu NR 12 TC 4 Z9 4 U1 1 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2015 VL 53 IS 1 BP 298 EP 301 DI 10.1128/JCM.02715-14 PG 4 WC Microbiology SC Microbiology GA AW8HM UT WOS:000346502200045 PM 25355768 ER PT J AU Vieira-Damiani, G Diniz, PPVD Pitassi, LHU Sowy, S Scorpio, DG Lania, BG Drummond, MR Soares, TCB Barjas-Castro, MD Breitschwerdt, EB Nicholson, WL Velho, PENF AF Vieira-Damiani, Gislaine Diniz, Pedro Paulo Vissotto de Paiva Urso Pitassi, Luiza Helena Sowy, Stanley Scorpio, Diana Gerardi Lania, Bruno Grosselli Drummond, Marina Rovani Benetti Soares, Tania Cristina Barjas-Castro, Maria de Lourdes Breitschwerdt, Edward B. Nicholson, William L. Neves Ferreira Velho, Paulo Eduardo TI Bartonella clarridgeiae Bacteremia Detected in an Asymptomatic Blood Donor SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID CAT-SCRATCH-DISEASE; ENDOTHELIAL-CELLS; HENSELAE; ENDOCARDITIS; TRANSFUSION; INFECTION; PATHOGEN; PATIENT; FEVER; LYMPHADENOPATHY AB Human exposure to Bartonella clarridgeiae has been reported only on the basis of antibody detection. We report for the first time an asymptomatic human blood donor infected with B. clarridgeiae, as documented by enrichment blood culture, PCR, and DNA sequencing. C1 [Vieira-Damiani, Gislaine; Urso Pitassi, Luiza Helena; Lania, Bruno Grosselli; Drummond, Marina Rovani; Benetti Soares, Tania Cristina; Neves Ferreira Velho, Paulo Eduardo] Univ Estadual Campinas, UNICAMP, Sch Med, Dept Med,iv Dermatol, Campinas, SP, Brazil. [Diniz, Pedro Paulo Vissotto de Paiva; Sowy, Stanley] Western Univ Hlth Sci, Coll Vet Med, Pomona, CA 91766 USA. [Scorpio, Diana Gerardi] Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD USA. [Barjas-Castro, Maria de Lourdes] Univ Estadual Campinas, UNICAMP, Sch Med, Dept Med,Div Hematol, Campinas, SP, Brazil. [Breitschwerdt, Edward B.] N Carolina State Univ, Coll Vet Med, Intracellular Pathogens Res Lab, Raleigh, NC 27695 USA. [Nicholson, William L.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA USA. RP Diniz, PPVD (reprint author), Western Univ Hlth Sci, Coll Vet Med, Pomona, CA 91766 USA. EM diniz@westernu.edu RI Lania, Bruno/J-7496-2012 OI Lania, Bruno/0000-0003-4949-7444 FU Faculty Grant in Global Health from the Johns Hopkins Center for Global Health; FAEPEX-UNICAMP (Fundo de Apoio ao Ensino, a Pesquisa e a Extensao-UNICAMP); Office of the Vice President for Research and Biotechnology, Western University, Western University of Health Sciences, Pomona, CA FX This work was partially supported by a Faculty Grant in Global Health to D.G.S. from the Johns Hopkins Center for Global Health; a grant from FAEPEX-UNICAMP (Fundo de Apoio ao Ensino, a Pesquisa e a Extensao-UNICAMP); and a summer research scholarship to Stanley Sowy from the Office of the Vice President for Research and Biotechnology, Western University, Western University of Health Sciences, Pomona, CA. NR 44 TC 2 Z9 2 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2015 VL 53 IS 1 BP 352 EP 356 DI 10.1128/JCM.00934-14 PG 5 WC Microbiology SC Microbiology GA AW8HM UT WOS:000346502200060 PM 25392353 ER PT J AU Martines, RB Ng, DL Greer, PW Rollin, PE Zaki, SR AF Martines, Roosecelis Brasil Ng, Dianna L. Greer, Patricia W. Rollin, Pierre E. Zaki, Sherif R. TI Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses SO JOURNAL OF PATHOLOGY LA English DT Review DE filovirus; pathology; immunohistochemistry; Ebola virus; Marburg virus; pathogenesis; haemorrhagic fever; electron microscopy; autopsy ID ACUTE RESPIRATORY SYNDROME; VIRAL HEMORRHAGIC-FEVER; NIEMANN-PICK C1; DC-SIGN; DENDRITIC CELLS; ELECTRON-MICROSCOPY; CYNOMOLGUS MACAQUES; FILOVIRUS ENTRY; RHESUS MACAQUES; GUINEA-PIGS AB Ebola viruses and Marburg viruses include some of the most virulent and fatal pathogens known to humans. These viruses cause severe haemorrhagic fevers, with case fatality rates in the range 25-90%. The diagnosis of filovirus using formalin-fixed tissues from fatal cases poses a significant challenge. The most characteristic histopathological findings are seen in the liver; however, the findings overlap with many other viral and non-viral haemorrhagic diseases. The need to distinguish filovirus infections from other haemorrhagic fevers, particularly in areas with multiple endemic viral haemorrhagic agents, is of paramount importance. In this review we discuss the current state of knowledge of filovirus infections and their pathogenesis, including histopathological findings, epidemiology, modes of transmission and filovirus entry and spread within host organisms. The pathogenesis of filovirus infections is complex and involves activation of the mononuclear phagocytic system, with release of pro-inflammatory cytokines, chemokines and growth factors, endothelial dysfunction, alterations of the innate and adaptive immune systems, direct organ and endothelial damage from unrestricted viral replication late in infection, and coagulopathy. Although our understanding of the pathogenesis of filovirus infections has rapidly increased in the past few years, many questions remain unanswered. Copyright (c) 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. C1 [Martines, Roosecelis Brasil; Ng, Dianna L.; Greer, Patricia W.; Zaki, Sherif R.] CDC, Infect Dis Pathol Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA 30329 USA. [Rollin, Pierre E.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA USA. RP Zaki, SR (reprint author), CDC, Infect Dis Pathol Branch, Div High Consequence Pathogens & Pathol, NCEZID, 1600 Clifton Rd NE,MS G32, Atlanta, GA 30329 USA. EM szaki@cdc.gov NR 140 TC 56 Z9 63 U1 12 U2 112 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3417 EI 1096-9896 J9 J PATHOL JI J. Pathol. PD JAN PY 2015 VL 235 IS 2 BP 153 EP 174 DI 10.1002/path.4456 PG 22 WC Oncology; Pathology SC Oncology; Pathology GA AW3MH UT WOS:000346190300002 PM 25297522 ER PT J AU Muehlenbachs, A Bhatnagar, J Zaki, SR AF Muehlenbachs, Atis Bhatnagar, Julu Zaki, Sherif R. TI Tissue tropism, pathology and pathogenesis of enterovirus infection SO JOURNAL OF PATHOLOGY LA English DT Review DE enterovirus; autopsy; immunohistochemistry; PCR; immunohistochemistry; meningoencephalitis; neonatal and congenital infections ID POLYMERASE-CHAIN-REACTION; DECAY-ACCELERATING FACTOR; CENTRAL-NERVOUS-SYSTEM; COXSACKIE-B VIRUSES; HUMAN HEART-DISEASE; MOUTH-DISEASE; RT-PCR; POLIOVIRUS PERSISTENCE; DILATED CARDIOMYOPATHY; ADENOVIRUS RECEPTOR AB Enteroviruses are very common and cause infections with a diverse array of clinical features. Enteroviruses are most frequently considered by practising pathologists in cases of aseptic meningitis, encephalitis, myocarditis and disseminated infections in neonates and infants. Congenital infections have been reported and transplacental transmission is thought to occur. Although skin biopsies during hand, foot and mouth disease are infrequently obtained, characteristic dermatopathological findings can be seen. Enteroviruses have been implicated in lower respiratory tract infections. This review highlights histopathological features of enterovirus infection and discusses diagnostic modalities for formalin-fixed paraffin-embedded tissues and their associated pitfalls. Immunohistochemistry can detect enterovirus antigen within cells of affected tissues; however, assays can be non-specific and detect other viruses. Molecular methods are increasingly relied upon but, due to the high frequency of asymptomatic enteroviral infections, clinical-pathological correlation is needed to determine significance. Of note, diagnostic assays on central nervous system or cardiac tissues from immunocompetent patients with prolonged disease courses are most often negative. Histopathological, immunohistochemical and molecular studies performed on clinical specimens also provide insight into enteroviral tissue tropism and pathogenesis. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. C1 [Muehlenbachs, Atis; Bhatnagar, Julu; Zaki, Sherif R.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA USA. RP Muehlenbachs, A (reprint author), CDC, Infect Dis Pathol Branch, Div High Consequence Pathogens & Pathol, NCEZID, 1600 Clifton Rd NE,MS G32, Atlanta, GA 30329 USA. EM vkd6@cdc.gov NR 99 TC 27 Z9 27 U1 6 U2 21 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3417 EI 1096-9896 J9 J PATHOL JI J. Pathol. PD JAN PY 2015 VL 235 IS 2 BP 217 EP 228 DI 10.1002/path.4438 PG 12 WC Oncology; Pathology SC Oncology; Pathology GA AW3MH UT WOS:000346190300007 PM 25211036 ER PT J AU Clemente, MG Patton, JT Yolken, R Whitington, PF Parashar, UD Jiang, BM Raghunathan, T Schwarz, KB AF Clemente, Maria Grazia Patton, John T. Yolken, Robert Whitington, Peter F. Parashar, Umesh D. Jiang, Baoming Raghunathan, Trivellore Schwarz, Kathleen B. TI Prevalence of Groups A and C Rotavirus Antibodies in Infants with Biliary Atresia and Cholestatic Controls SO JOURNAL OF PEDIATRICS LA English DT Article ID UNITED-STATES; INFECTION; CHILDREN; MODEL; ANTIGENEMIA; DEPOSITS; DISEASE; GROWTH; CELLS; MICE AB Objective To analyze the prevalence of acute asymptomatic group A and C rotavirus (RV-A and RV-C) infection in neonates with cholestasis. Study design Participants were infants <180 days of age with cholestasis (serum direct or conjugated bilirubin >20% of total and >= 2 mg/dL) enrolled in the Childhood Liver Disease Research and Education Network during RV season (December-May). Forty infants with biliary atresia (BA), age 62 +/- 29 days (range, 4.7-13 weeks) and 38 infants with cholestasis, age 67 +/- 44 days (range, 3-15.8 weeks) were enrolled. Results At enrollment, RV-A IgM positivity rates did not differ between infants with BA (10%) vs those without (18%) (P = .349). RV-C IgM was positive in 0% of infants with BA vs 3% in those without BA (P = .49). RV-A IgG was lower in infants with BA: 51 +/- 39 vs 56 +/- 44 enzyme-linked immunoassay unit, P = .045 but this difference may lack biological relevance as maternal RV-A IgG titers were similar between groups. Infant RV-A IgM titers at 2-6 months follow-up increased markedly vs at presentation in both infants with BA (50 +/- 30 vs 9 +/- 9) and those without (43 +/- 18 vs 16 +/- 20 enzyme-linked immunoassay unit) (P < .0001), without differences between groups. Conclusions RV-A infection in the first 6 months of life is common in infants with cholestasis of any cause. RV-A could have different pathogenetic effects by initiating different hepatic immune responses in infants with vs without BA or could lack pathogenetic significance. C1 [Clemente, Maria Grazia; Schwarz, Kathleen B.] Johns Hopkins Med Inst, Dept Pediat, Baltimore, MD 21287 USA. [Patton, John T.] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA. [Yolken, Robert] Johns Hopkins Univ, Sch Med, Stanley Div Dev Neurovirol, Baltimore, MD USA. [Whitington, Peter F.] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA. [Parashar, Umesh D.; Jiang, Baoming] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. [Raghunathan, Trivellore] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA. RP Schwarz, KB (reprint author), Johns Hopkins Med Inst, Dept Pediat, CMSC 2-125,600 North Wolfe St, Baltimore, MD 21287 USA. EM kschwarz@jhmi.edu OI Clemente, Maria Grazia/0000-0002-4586-3868 FU National Institute of Diabetes and Digestive and Kidney Diseases [U54DK078377, DK 62530]; National Center for Research Resources, National Institutes of Health (NIH) [5M01 RR00069, UL1RR025005]; Zachary Meehan Foundation; Sydney Moss Foundation; Johns Hopkins Pediatric Liver Center Gift Fund; Intramural Research Program of the National Institute of Allergy and Infectious Diseases of NIH FX Supported by the National Institute of Diabetes and Digestive and Kidney Diseases (U54DK078377, DK 62530 [Johns Hopkins]), and National Center for Research Resources, National Institutes of Health (NIH; 5M01 RR00069 [University of Colorado], UL1RR025005 [Johns Hopkins]) Zachary Meehan Foundation, Sydney Moss Foundation, the Johns Hopkins Pediatric Liver Center Gift Fund. J.P. was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases of NIH. The finding and conclusions in this report are those of the authors and do not necessarily represent the views of CDC. The authors declare no conflicts of interest. NR 31 TC 1 Z9 1 U1 2 U2 6 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD JAN PY 2015 VL 166 IS 1 BP 79 EP + DI 10.1016/j.jpeds.2014.09.033 PG 7 WC Pediatrics SC Pediatrics GA AW9NI UT WOS:000346584000019 PM 25444003 ER PT J AU Razzaghi, H Oster, M Reefhuis, J AF Razzaghi, Hilda Oster, Matthew Reefhuis, Jennita TI Long-Term Outcomes in Children with Congenital Heart Disease: National Health Interview Survey SO JOURNAL OF PEDIATRICS LA English DT Article ID QUALITY-OF-LIFE; NEURODEVELOPMENTAL OUTCOMES; SPECTRUM DISORDERS; FOLLOW-UP; SURGERY; DEFECTS; ADULTS; CARE; POPULATION; REPAIR AB Objective To assess the extent of long-term morbidity in children with congenital heart disease (CHD). Study design We used data from the 1997-2011 National Health Interview Survey to study long-term outcomes in children aged 0-17 years with CHD. Parents were asked whether their child was diagnosed with CHD. We assessed for comorbidities, including autism/autism spectrum disorders; healthcare utilization, including number of emergency room visits; and daily life aspects, including number of days of school missed. These outcomes were compared between children with and without reported CHD using ORs and chi(2) statistics. Results The study included 420 children with reported CHD and 180 048 children without CHD, with no significant between-group differences in age and sex. The odds of reporting worse health and more than 10 days of school/daycare missed in the previous year were 3 times higher for the children with CHD compared with those without CHD. Children aged 2-17 with CHD were more likely than those without CHD to have had a diagnosis of autism spectrum disorder (crude OR, 4.6; 95% CI, 1.9-11.0) or intellectual disability (crude OR, 9.1; 95% CI, 5.4-15.4). The rates of emergency room, home, and doctors' office visits were significantly higher in the children with CHD. Conclusion Reported adverse outcomes were more prevalent in the children with CHD. Our findings, particularly those regarding neurodevelopmental outcomes, may be helpful for parents, healthcare providers, and others in assessing the specific needs of children and teenagers with CHD. C1 [Razzaghi, Hilda; Oster, Matthew; Reefhuis, Jennita] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Razzaghi, Hilda] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Oster, Matthew] Emory Univ, Sch Med, Childrens Healthcare Atlanta, Atlanta, GA USA. RP Razzaghi, H (reprint author), Ctr Dis Control & Prevent, Mail Stop E86,1600 Clifton Rd, Atlanta, GA 30333 USA. EM hir2@cdc.gov FU Research Participation program for the Centers for Disease Control and Prevention FX H.R. was supported by an appointment to the Research Participation program for the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education through an agreement between the Department of Energy and Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of Centers for Disease Control and Prevention. The authors declare no conflicts of interest. NR 38 TC 5 Z9 5 U1 2 U2 15 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD JAN PY 2015 VL 166 IS 1 BP 119 EP + DI 10.1016/j.jpeds.2014.09.006 PG 7 WC Pediatrics SC Pediatrics GA AW9NI UT WOS:000346584000026 PM 25304924 ER PT J AU Harris-Adamson, C Eisen, EA Kapellusch, J Garg, A Hegmann, KT Thiese, MS Dale, AM Evanoff, B Burt, S Bao, S Silverstein, B Merlino, L Gerr, F Rempel, D AF Harris-Adamson, Carisa Eisen, Ellen A. Kapellusch, Jay Garg, Arun Hegmann, Kurt T. Thiese, Matthew S. Dale, Ann Marie Evanoff, Bradley Burt, Susan Bao, Stephen Silverstein, Barbara Merlino, Linda Gerr, Fred Rempel, David TI Biomechanical risk factors for carpal tunnel syndrome: a pooled study of 2474 workers SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article ID HAND ACTIVITY LEVEL; MUSCULOSKELETAL DISORDERS; OCCUPATIONAL COHORT; SYNDROME CTS; MANUAL WORK; PREVALENCE; EXPOSURE; REPETITION; WRIST; POPULATION AB Background Between 2001 and 2010, five research groups conducted coordinated prospective studies of carpal tunnel syndrome (CTS) incidence among US workers from various industries and collected detailed subject-level exposure information with follow-up of symptoms, electrophysiological measures and job changes. Objective This analysis examined the associations between workplace biomechanical factors and incidence of dominant-hand CTS, adjusting for personal risk factors. Methods 2474 participants, without CTS or possible polyneuropathy at enrolment, were followed up to 6.5 years (5102 person-years). Individual workplace exposure measures of the dominant hand were collected for each task and included force, repetition, duty cycle and posture. Task exposures were combined across the workweek using time-weighted averaging to estimate job-level exposures. CTS case-criteria were based on symptoms and results of electrophysiological testing. HRs were estimated using Cox proportional hazard models. Results After adjustment for covariates, analyst (HR=2.17; 95% CI 1.38 to 3.43) and worker (HR=2.08; 95% CI 1.31 to 3.39) estimated peak hand force, forceful repetition rate (HR=1.84; 95% CI 1.19 to 2.86) and per cent time spent (eg, duty cycle) in forceful hand exertions (HR=2.05; 95% CI 1.34 to 3.15) were associated with increased risk of incident CTS. Associations were not observed between total hand repetition rate, per cent duration of all hand exertions, or wrist posture and incident CTS. Conclusions In this prospective multicentre study of production and service workers, measures of exposure to forceful hand exertion were associated with incident CTS after controlling for important covariates. These findings may influence the design of workplace safety programmes for preventing work-related CTS. C1 [Harris-Adamson, Carisa; Eisen, Ellen A.] Univ Calif Berkeley, Dept Environm Hlth Sci, Berkeley, CA 94720 USA. [Harris-Adamson, Carisa] Samuel Merritt Univ, Dept Phys Therapy, Oakland, CA USA. [Kapellusch, Jay; Garg, Arun] Univ Wisconsin, Ctr Ergon, Milwaukee, WI 53201 USA. [Hegmann, Kurt T.; Thiese, Matthew S.] Univ Utah, RMCOEH, Salt Lake City, UT USA. [Dale, Ann Marie; Evanoff, Bradley] Washington Univ, Sch Med, Div Gen Med Sci, St Louis, MO USA. [Burt, Susan] NIOSH, Cincinnati, OH 45226 USA. [Bao, Stephen; Silverstein, Barbara] Washington State Dept Labor & Ind, Safety & Hlth Assessment & Res Prevent SHARP Prog, Olympia, WA 98504 USA. [Merlino, Linda; Gerr, Fred] Univ Iowa, Coll Publ Hlth, Dept Occupat & Environm Hlth, Iowa City, IA USA. [Rempel, David] Univ Calif San Francisco, Div Occupat & Environm Med, San Francisco, CA 94143 USA. [Rempel, David] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA. RP Rempel, D (reprint author), 1301 South 46th St Bldg 163, Richmond, CA 94804 USA. EM david.rempel@ucsf.edu OI Evanoff, Bradley A./0000-0003-0085-333X FU Center for Disease Control/National Institute for Occupational Safety and Health [R01OH009712]; National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) [UL1 TR000448] FX This study was supported by research funding from the Center for Disease Control/National Institute for Occupational Safety and Health (R01OH009712), and by Washington University Institute of Clinical and Translational Sciences Award (CTSA; grant # UL1 TR000448) from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH). NR 37 TC 14 Z9 14 U1 6 U2 18 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1351-0711 EI 1470-7926 J9 OCCUP ENVIRON MED JI Occup. Environ. Med. PD JAN PY 2015 VL 72 IS 1 BP 33 EP 41 DI 10.1136/oemed-2014-102378 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AW6DM UT WOS:000346359600008 PM 25324489 ER PT J AU von Mollendorf, C Cohen, C de Gouveia, L Naidoo, N Meiring, S Quan, V Lindani, S Moore, DP Reubenson, G Moshe, M Eley, B Hallbauer, UM Finlayson, H Madhi, SA Conklin, L Zell, ER Klugman, KP Whitney, CG von Gottberg, A AF von Mollendorf, Claire Cohen, Cheryl de Gouveia, Linda Naidoo, Nireshni Meiring, Susan Quan, Vanessa Lindani, Sonwabo Moore, David P. Reubenson, Gary Moshe, Mamokgethi Eley, Brian Hallbauer, Ute M. Finlayson, Heather Madhi, Shabir A. Conklin, Laura Zell, Elizabeth R. Klugman, Keith P. Whitney, Cynthia G. von Gottberg, Anne CA South African IPD Case-Control TI Risk Factors for Invasive Pneumococcal Disease Among Children Less Than 5 Years of Age in a High HIV Prevalence Setting, South Africa, 2010 to 2012 SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE pneumococcus; risk factors; HIV; HIV exposure; children; South Africa; pneumococcal conjugate vaccine ID IMMUNODEFICIENCY-VIRUS-INFECTION; CONJUGATE VACCINE; STREPTOCOCCUS-PNEUMONIAE; ANTIBIOTIC-RESISTANCE; UNINFECTED INFANTS; ERA AB Background: Invasive pneumococcal disease (IPD) causes significant disease burden, especially in developing countries, even in the era of pneumococcal conjugate vaccine and maternal-to-child HIV transmission prevention programs. We evaluated factors that might increase IPD risk in young children in a high HIV prevalence setting. Methods: We conducted a case-control study using IPD cases identified at 24 Group for Enteric, Respiratory and Meningeal disease Surveillance-South Africa program sites (2010-2012). At least 4 controls were matched by age, HIV status and hospital to each case. Potential risk factors were evaluated using multivariable conditional logistic regression. Results: In total, 486 age-eligible cases were enrolled. Factors associated with IPD in HIV-uninfected children (237 cases, 928 controls) included siblings < 5 years [adjusted odds ratio (aOR) = 1.68, 95% confidence interval (CI): 1.16-2.46], underlying medical conditions (aOR = 1.99, CI 1.22-3.22), preceding upper respiratory tract infection (aOR = 1.79, CI 1.19-2.69), day-care attendance (aOR = 1.58, CI 1.01-2.47), perinatal HIV exposure (aOR = 1.62, CI 1.10-2.37), household car ownership (aOR = 0.45, CI 0.25-0.83) and = 2 7-valent pneumococcal conjugate vaccine doses (aOR = 0.67, CI 0.46-0.99). Among HIV-infected children (124 cases, 394 controls), IPD-associated factors included malnutrition (aOR = 2.68, CI 1.40-5.14), upper respiratory tract infection (aOR = 3.49, CI 1.73-7.03), tuberculosis in the last 3 months (aOR = 5.12, CI 1.69-15.50) and current antiretroviral treatment (aOR = 0.13, CI 0.05-0.38). Conclusion: Previously identified factors related to poverty, poor health and intense exposure continue to be risk factors for IPD in children. Ensuring delivery of pneumococcal conjugate vaccine and antiretroviral treatment are important for improving disease prevention. C1 [von Mollendorf, Claire; Cohen, Cheryl; de Gouveia, Linda; Naidoo, Nireshni; Madhi, Shabir A.; von Gottberg, Anne] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Ctr Resp Dis & Meningitis, Johannesburg, South Africa. [von Mollendorf, Claire; Cohen, Cheryl; Naidoo, Nireshni] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa. [Meiring, Susan; Quan, Vanessa; Lindani, Sonwabo] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Div Publ Hlth Surveillance & Response, Johannesburg, South Africa. [Moore, David P.; Madhi, Shabir A.] Natl Res Fdn Vaccine Preventable Dis, Dept Sci & Technol, Gauteng, South Africa. [Moore, David P.; Madhi, Shabir A.; Klugman, Keith P.; von Gottberg, Anne] Univ Witwatersrand, Fac Hlth Sci, Med Res Council Resp & Meningeal Pathogens Res Un, Johannesburg, South Africa. [Reubenson, Gary] Univ Witwatersrand, Fac Hlth Sci, Dept Paediat & Child Hlth, Rahima Moosa Mother & Child Hosp, Johannesburg, South Africa. [Moshe, Mamokgethi] Medunsa Univ, Dept Paediat, Dr George Mukhari Hosp, Johannesburg, South Africa. [Eley, Brian] Red Cross War Mem Childrens Hosp, Cape Town, Western Cape, South Africa. [Eley, Brian] Univ Cape Town, Dept Paediat & Child Hlth, ZA-7925 Cape Town, Western Cape, South Africa. [Hallbauer, Ute M.] Univ Orange Free State, Dept Paediat & Child Hlth, Univ & Pelonomi Hosp, Bloemfontein, Free State, South Africa. [Finlayson, Heather] Univ Stellenbosch, Tygerberg Hosp, Cape Town, Western Cape, South Africa. [Finlayson, Heather] Univ Stellenbosch, Dept Paediat & Child Hlth, Cape Town, Western Cape, South Africa. [Conklin, Laura; Zell, Elizabeth R.; Whitney, Cynthia G.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Klugman, Keith P.] Emory Univ, Hubert Dept Global Hlth, Atlanta, GA 30322 USA. RP von Mollendorf, C (reprint author), Natl Inst Communicable Dis, Ctr Resp Dis & Meningitis, Private Bag X4, ZA-2131 Johannesburg, Gauteng, South Africa. EM clairevm@nicd.ac.za FU NICD/NHLS; Global Alliance for Vaccines and Immunisation (GAVI)-Accelerated Vaccine Initiative-Special Studies Team; Pfizer; GlaxoSmithKline FX This manuscript has been supported by NICD/NHLS and the Global Alliance for Vaccines and Immunisation (GAVI)-Accelerated Vaccine Initiative-Special Studies Team.; K.P.K. and S.A.M. have received research funding and honoraria from Pfizer and GlaxoSmithKline. A.v.G. has received research funding from Pfizer. C.v.M. has received honoraria from Pfizer. G.R. has received honoraria and conference support from Pfizer and Sanofi. C.C., L.d.G., N.N., S.L., S.M., V.Q., D.P.M., M.M., B.E., U.M.H., H.F., L.C., E.R.Z., and C.G.W. report no conflicts of interest. NR 34 TC 2 Z9 2 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JAN PY 2015 VL 34 IS 1 BP 27 EP 34 DI 10.1097/INF.0000000000000484 PG 8 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA AW8GH UT WOS:000346498800008 PM 24992122 ER PT J AU Howley, MM Painter, JA Katz, DJ Graviss, EA Reves, R Beavers, SF Garrett, DO AF Howley, Meredith M. Painter, John A. Katz, Dolores J. Graviss, Edward A. Reves, Randall Beavers, Suzanne F. Garrett, Denise O. CA TB Epidemiologic Studies TI Evaluation of QuantiFERON-TB Gold In-Tube and Tuberculin Skin Tests Among Immigrant Children Being Screened for Latent Tuberculosis Infection SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE tuberculosis; latent tuberculosis infection; interferon-gamma release assay; tuberculin skin test; foreign birth ID GAMMA RELEASE ASSAY; MYCOBACTERIUM-TUBERCULOSIS; CHILDHOOD TUBERCULOSIS; BLOOD-TESTS; DIAGNOSIS; METAANALYSIS; ADOLESCENTS; PERFORMANCE; DISEASE; RISK AB Background: Centers for Disease Control and Prevention requirements for pre-immigration tuberculosis (TB) screening of children 2-to 14-years old permit a tuberculin skin test (TST) or an interferon-gamma release assay (IGRA). Few data are available on the performance of IGRAs versus TSTs in foreign-born children. Methods: We compared the performance of TST and QuantiFERON-TB (QFT) Gold In-Tube in children 2-to 14-years old applying to immigrate to the United States from Mexico, the Philippines and Vietnam, using diagnosis of TB in immigrating family members as a measure of potential exposure. Results: We enrolled 2520 children: 664 (26%) were TST+ and 142 (5.6%) were QFT+. One hundred and eleven (4.4%) were TST+/QFT+, 553 (21.9%) were TST+/QFT- and 31 (1.2%) were TST-/QFT+. Agreement between tests was poor (kappa = 0.20). Although positive results of both tests were significantly associated with older age (relative risks [RR] TST+, 1.64; 95% confidence interval [CI]: 1.36-1.97; RR QFT+, 3.05; 95% CI: 1.725.38) and with the presence of TB in at least 1 immigrating family member (RR TST+, 1.40; 95% CI: 1.12-1.75; RR QFT+ 2.24; 95% CI: 1.18-4.28), QFT+ results were more strongly associated with both predictive variables. Conclusions: The findings support the preferential use of QFT over TST for pre-immigration screening of foreign-born children 2 years of age and older and lend support to the preferential use of IGRAs in testing foreign-born children for latent TB infection. C1 [Howley, Meredith M.; Painter, John A.; Katz, Dolores J.; Beavers, Suzanne F.; Garrett, Denise O.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Graviss, Edward A.] Methodist Hosp, Res Inst, Houston, TX 77030 USA. [Reves, Randall] Denver Hlth & Hosp Author, Denver, CO USA. RP Howley, MM (reprint author), Ctr Dis Control & Prevent, Mailstop F-61,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM meredith.howley@health.ny.gov FU Centers for Disease Control and Prevention, Tuberculosis Epidemiologic Studies Consortium FX Research was funded by the Centers for Disease Control and Prevention, Tuberculosis Epidemiologic Studies Consortium. The authors have no conflicts of interest or financial relationships relevant to this manuscript to disclose. NR 39 TC 13 Z9 13 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JAN PY 2015 VL 34 IS 1 BP 35 EP 39 DI 10.1097/INF.0000000000000494 PG 5 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA AW8GH UT WOS:000346498800009 PM 25093974 ER PT J AU Zhang, J Liu, HX Jia, L Payne, DC Hall, AJ Xu, ZQ Gao, ZY Chang, ZR Jiang, BM Parashar, UD Meng, L Yu, HJ Duan, ZJ AF Zhang, Jing Liu, Haixia Jia, Lei Payne, Daniel C. Hall, Aron J. Xu, Ziqian Gao, Zhiyong Chang, Zhaorui Jiang, Baoming Parashar, Umesh D. Meng, Lei Yu, Hongjie Duan, Zhaojun TI Active, Population-based Surveillance for Rotavirus Gastroenteritis in Chinese Children: Beijing Municipality and Gansu Province, China SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE rotavirus; child; population-based surveillance; hospitalization rate; medical-related cost ID REPUBLIC-OF-CHINA; DISEASE BURDEN; DIARRHEA; HOSPITALIZATION; METAANALYSIS; VACCINATION; JAPAN AB Background: Estimates of population-based incidence for rotavirus inpatient and outpatient visits, as well as their associated medical costs, can provide valuable information to assess the potential benefits of rotavirus vaccination. Methods: We conducted active surveillance for rotavirus gastroenteritis at 6 medical institutions for children younger than 5 years from July 2012 to June 2013 in Beijing Municipality and Gansu Province. We collected stool samples of diarrhea patients for testing rotavirus, and epidemiological, clinical and cost data. Results: The proportion of rotavirus-positive for inpatient and outpatient visits from Beijing was 28.7% (138/481) and 19.4% (133/687); a statistically lower proportion than observed in Gansu among inpatient visits (45.2%, 245/542, P < 0.001) and among outpatient visits (28.8%, 66/229, P = 0.003), respectively. The G9P[8] genotype was most prevalent in Beijing (60.6%) and in Gansu (77.6%). The median Vesikari scale value was 16 for rotavirus inpatients and 15 for nonrotavirus inpatients. Population-based estimated rates of rotavirus-related hospitalizations were 14.4 (95% CI, 13-16) per 10,000 children, and the rate of rotavirus gastroenteritis in the outpatient setting was 149 (95% CI, 145-153) per 10,000 children younger than 5 years. The estimated total number of rotavirus-related inpatient visits were 3790 (95% CI, 2488-3827) cases and 29,101 (95% CI: 27,74829,279) outpatient visits. The total cost of rotavirus infection was $ 1.4 million (95% CI, $ 0.9-1.4 million) for hospitalizations and $ 4.2 million (95% CI, $ 4.0-4.2 million) for outpatient visits per year in Beijing and Gansu. Conclusion: Rotavirus gastroenteritis is associated with a large disease burden in Chinese children younger than 5 years in Beijing and Gansu. Rotavirus is the most common cause of severe acute gastroenteritis (AGE) in children younger than 5 years worldwide, accounting for an estimated 25 million clinic visits, 2 million hospitalizations and 453,000 deaths each year. 1,2 In China, the world's most populous nation, surveillance at sentinel hospitals showed that approximately 48% of AGE hospitalizations among children younger than 5 years were attributed to rotavirus from 2003 to 2007, and 13,387 rotavirus deaths were estimated in China in 2002 alone. 3,4 The Lanzhou lamb rotavirus vaccine, consisting of serotype G10P[12], was licensed in 2000 but is not included in the National Expanded Program of Immunization vaccine recommendations for Chinese children. 5 License applications for new rotavirus vaccines (Rotarix, produced by GlaxoSmithKline Biologicals, and RotaTeq, produced by Merck and Company) have been submitted for administering these vaccines to Chinese infants. C1 [Zhang, Jing; Chang, Zhaorui; Yu, Hongjie] Chinese Ctr Dis Control & Prevent, Div Infect Dis, Key Lab Surveillance & Early Warning Infect Dis, Beijing 102206, Peoples R China. [Liu, Haixia; Meng, Lei] Gansu Prov Ctr Dis Control & Prevent, Lanzhou, Peoples R China. [Jia, Lei; Gao, Zhiyong] Beijing Municipal Ctr Dis Control & Prevent, Beijing, Peoples R China. [Payne, Daniel C.; Hall, Aron J.; Jiang, Baoming; Parashar, Umesh D.] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. [Xu, Ziqian; Duan, Zhaojun] Chinese Ctr Dis Control & Prevent, Inst Viral Dis Prevent & Control, Beijing, Peoples R China. RP Zhang, J (reprint author), Chinese Ctr Dis Control & Prevent, Div Infect Dis, Beijing 102206, Peoples R China. EM zhangjing@chinacdc.cn; dvp6@cdc.gov FU Chinese Center for Disease Control and Prevention FX We thank the participation of all enrollees in 6 hospitals (Beijing Children's Hospital, Peking University First Hospital, Capital Pediatric Research Institute, and Tong Zhou District Women and Children's Medical Center, Lanzhou University Hospital and Liangzhou District Hospital of Wuwei city) and local Center for Disease Control and Prevention (CDC) including Beijing Municipality CDC, CDC of Chaoyang district of Beijing, Xicheng district of Beijing and Tongzhou district of Beijing; Gansu Provincial CDC and CDC of Liangzhou district of Wuwei city in Gansu in this study. We thank the support by the fund for annual disease surveillance of Chinese Center for Disease Control and Prevention. NR 28 TC 4 Z9 7 U1 1 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JAN PY 2015 VL 34 IS 1 BP 40 EP 46 DI 10.1097/INF.0000000000000505 PG 7 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA AW8GH UT WOS:000346498800010 PM 25105897 ER PT J AU Torres-Torres, S Myers, AL Klatte, JM Rhoden, EE Oberste, MS Collett, MS McCulloh, RJ AF Torres-Torres, Sanet Myers, Angela L. Klatte, J. Michael Rhoden, Eric E. Oberste, M. Steven Collett, Marc S. McCulloh, Russell J. TI First Use of Investigational Antiviral Drug Pocapavir (V-073) for Treating Neonatal Enteroviral Sepsis SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE neonatal enterovirus infection; pocapavir; coxsackievirus ID INFECTION AB Neonatal enteroviral sepsis is a potentially fatal condition. Perinatally acquired infection and severe coagulopathy can be associated with a poor clinical outcome, and antiviral therapy is currently unavailable. Pocapavir (V-073) is an investigational drug candidate being developed for poliovirus indications, but also has variable antiviral activity against nonpolio enteroviruses. We describe the first use of pocapavir in treating a case of severe neonatal enteroviral sepsis due to Coxsackievirus B3. C1 [Torres-Torres, Sanet; Myers, Angela L.; Klatte, J. Michael; McCulloh, Russell J.] Childrens Mercy, Pediat Infect Dis, Kansas City, MO USA. [Rhoden, Eric E.; Oberste, M. Steven] Ctr Dis Control & Prevent, Atlanta, GA USA. [Collett, Marc S.] ViroDefense Inc, Rockville, MD USA. RP McCulloh, RJ (reprint author), Childrens Mercy Kansas City, 2401 Gillham Rd, Kansas City, MO 64108 USA. EM rmcculloh@cmh.edu NR 10 TC 4 Z9 4 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JAN PY 2015 VL 34 IS 1 BP 52 EP 54 DI 10.1097/INF.0000000000000497 PG 3 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA AW8GH UT WOS:000346498800012 PM 25229269 ER PT J AU Cohen, C Walaza, S Moyes, J Groome, M Tempia, S Pretorius, M Hellferscee, O Dawood, H Chhagan, M Naby, F Haffejee, S Variava, E Kahn, K Nzenze, S Tshangela, A von Gottberg, A Wolter, N Cohen, AL Kgokong, B Venter, M Madhi, SA AF Cohen, Cheryl Walaza, Sibongile Moyes, Jocelyn Groome, Michelle Tempia, Stefano Pretorius, Marthi Hellferscee, Orienka Dawood, Halima Chhagan, Meera Naby, Fathima Haffejee, Summaya Variava, Ebrahim Kahn, Kathleen Nzenze, Susan Tshangela, Akhona von Gottberg, Anne Wolter, Nicole Cohen, Adam L. Kgokong, Babatyi Venter, Marietjie Madhi, Shabir A. TI Epidemiology of Viral-associated Acute Lower Respiratory Tract Infection Among Children < 5 Years of Age in a High HIV Prevalence Setting, South Africa, 2009-2012 SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE pneumonia; HIV; AIDS; children; lower respiratory tract infection; South Africa ID PNEUMOCOCCAL CONJUGATE VACCINE; STREPTOCOCCUS-PNEUMONIAE; ANTIRETROVIRAL TREATMENT; HOSPITALIZED CHILDREN; DISEASE; ETIOLOGY; BURDEN; CHALLENGES; MORTALITY; PATTERNS AB Background: Data on the epidemiology of viral-associated acute lower respiratory tract infection (LRTI) from high HIV prevalence settings are limited. We aimed to describe LRTI hospitalizations among South African children aged < 5 years. Methods: We prospectively enrolled hospitalized children with physician-diagnosed LRTI from 5 sites in 4 provinces from 2009 to 2012. Using polymerase chain reaction (PCR), nasopharyngeal aspirates were tested for 10 viruses and blood for pneumococcal DNA. Incidence was estimated at 1 site with available population denominators. Results: We enrolled 8723 children aged < 5 years with LRTI, including 64% < 12 months. The case-fatality ratio was 2% (150/8512). HIV prevalence among tested children was 12% (705/5964). The overall prevalence of respiratory viruses identified was 78% (6517/8393), including 37% rhinovirus, 26% respiratory syncytial virus (RSV), 7% influenza and 5% human metapneumovirus. Four percent (253/6612) tested positive for pneumococcus. The annual incidence of LRTI hospitalization ranged from 2530 to 3173/100,000 population and was highest in infants (8446-10532/100,000). LRTI incidence was 1.1 to 3.0-fold greater in HIV-infected than HIV-uninfected children. In multivariable analysis, compared to HIV-uninfected children, HIV-infected children were more likely to require supplemental-oxygen [odds ratio (OR): 1.3, 95% confidence interval (CI): 1.1-1.7)], be hospitalized > 7 days (OR: 3.8, 95% CI: 2.8-5.0) and had a higher case-fatality ratio (OR: 4.2, 95% CI: 2.6-6.8). In multivariable analysis, HIV-infection (OR: 3.7, 95% CI: 2.2-6.1), pneumococcal coinfection (OR: 2.4, 95% CI: 1.1-5.6), mechanical ventilation (OR: 6.9, 95% CI: 2.7-17.6) and receipt of supplemental-oxygen (OR: 27.3, 95% CI: 13.2-55.9) were associated with death. Conclusions: HIV-infection was associated with an increased risk of LRTI hospitalization and death. A viral pathogen, commonly RSV, was identified in a high proportion of LRTI cases. C1 [Cohen, Cheryl; Walaza, Sibongile; Moyes, Jocelyn; Pretorius, Marthi; Hellferscee, Orienka; Tshangela, Akhona; von Gottberg, Anne; Wolter, Nicole; Kgokong, Babatyi; Venter, Marietjie; Madhi, Shabir A.] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Ctr Resp Dis & Meningitis, Johannesburg, South Africa. [Cohen, Cheryl; Walaza, Sibongile; Moyes, Jocelyn] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa. [Groome, Michelle; Nzenze, Susan; von Gottberg, Anne; Wolter, Nicole; Madhi, Shabir A.] Univ Witwatersrand, Fac Hlth Sci, MRC, Resp & Meningeal Pathogens Res Unit, Johannesburg, South Africa. [Groome, Michelle; Nzenze, Susan; Madhi, Shabir A.] Univ Witwatersrand, Natl Res Fdn, Dept Sci & Technol, Johannesburg, South Africa. [Tempia, Stefano; Cohen, Adam L.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Tempia, Stefano; Cohen, Adam L.] Ctr Dis Control & Prevent South Africa, Influenza Programme, Pretoria, South Africa. [Dawood, Halima] Pietermaritzburg Metropolitan Hosp, Dept Med, Pietermaritzburg, South Africa. [Dawood, Halima] Univ KwaZulu Natal, Dept Med, Pietermaritzburg, South Africa. [Chhagan, Meera; Naby, Fathima] Pietermaritzburg Metropolitan Hosp, Dept Paediat, Pietermaritzburg, South Africa. [Haffejee, Summaya] Univ KwaZulu Natal, Sch Pathol, Pietermaritzburg, South Africa. [Variava, Ebrahim] Klerksdorp Tshepong Hosp, Dept Med, Klerksdorp, South Africa. [Variava, Ebrahim] Univ Witwatersrand, Fac Hlth Sci, Dept Med, Johannesburg, South Africa. [Kahn, Kathleen] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, MRC Wits Rural Publ Hlth & Hlth Transit Res Unit, Johannesburg, South Africa. [Kahn, Kathleen] Umea Univ, Ctr Global Hlth Res, Umea, Sweden. [Kahn, Kathleen] INDEPTH Network, Accra, Ghana. [Venter, Marietjie] Univ Pretoria, Dept Med Virol, Zoonoses Res Unit, Gauteng, South Africa. RP Cohen, C (reprint author), Natl Inst Communicable Dis, Ctr Resp Dis & Meningitis, Private Bag X4, ZA-2131 Johannesburg, Gauteng, South Africa. EM cherylc@nicd.ac.za RI Venter, Marietjie/P-9604-2016 OI Venter, Marietjie/0000-0003-2696-824X FU National Institute for Communicable Diseases of the National Health Laboratory Service; United States Centers for Disease Control and Prevention (CDC), Atlanta, Georgia Preparedness and Response to Avian and Pandemic Influenza in South Africa [U51/IP000155-04] FX This study received funding from the National Institute for Communicable Diseases of the National Health Laboratory Service and was supported in part by funds from the United States Centers for Disease Control and Prevention (CDC), Atlanta, Georgia Preparedness and Response to Avian and Pandemic Influenza in South Africa (Cooperative Agreement Number: U51/IP000155-04). The contents are solely the responsibility of the authors and do not necessarily represent the official views of the CDC. The funders had no role in study design, implementation, manuscript writing or the decision to submit for publication. The corresponding author had full access to all the data in the study and takes final responsibility for the decision to submit for publication. NR 42 TC 17 Z9 18 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JAN PY 2015 VL 34 IS 1 BP 66 EP 72 DI 10.1097/INF.0000000000000478 PG 7 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA AW8GH UT WOS:000346498800015 PM 25093972 ER PT J AU Becker-Dreps, S Vilchez, S Velasquez, D Moon, SS Hudgens, MG Zambrana, LE Jiang, BM AF Becker-Dreps, Sylvia Vilchez, Samuel Velasquez, Daniel Moon, Sung-Sil Hudgens, Michael G. Enrique Zambrana, Luis Jiang, Baoming TI Rotavirus-specific IgG Antibodies From Mothers' Serum May Inhibit Infant Immune Responses to the Pentavalent Rotavirus Vaccine SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Letter ID BREAST-MILK C1 [Becker-Dreps, Sylvia] Univ N Carolina, Sch Med, Dept Family Med, Chapel Hill, NC 27514 USA. [Vilchez, Samuel] Natl Autonomous Univ Nicaragua, Fac Med Sci, Dept Microbiol & Parasitol, Leon, Nicaragua. [Velasquez, Daniel; Moon, Sung-Sil; Jiang, Baoming] Ctr Dis Control & Prevent, Gastroenteritis & Resp Viruses Lab Branch, Div Viral Dis, Atlanta, GA USA. [Hudgens, Michael G.] Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Enrique Zambrana, Luis] Natl Autonomous Univ Nicaragua, Ctr Epidemiol & Hlth, Leon, Nicaragua. RP Becker-Dreps, S (reprint author), Univ N Carolina, Sch Med, Dept Family Med, Chapel Hill, NC 27514 USA. FU FIC NIH HHS [5K01TW008401-04, K01 TW008401] NR 5 TC 5 Z9 5 U1 2 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0891-3668 EI 1532-0987 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JAN PY 2015 VL 34 IS 1 BP 115 EP 116 DI 10.1097/INF.0000000000000481 PG 3 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA AW8GH UT WOS:000346498800031 PM 25741808 ER PT J AU Kerani, RP Stenger, MR Weinstock, H Bernstein, KT Reed, M Schumacher, C Samuel, MC Eaglin, M Golden, M AF Kerani, Roxanne P. Stenger, Mark R. Weinstock, Hillard Bernstein, Kyle T. Reed, Mary Schumacher, Christina Samuel, Michael C. Eaglin, Margaret Golden, Matthew TI Gonorrhea Treatment Practices in the STD Surveillance Network, 2010-2012 SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID DISEASES-TREATMENT-GUIDELINES; RESISTANT NEISSERIA-GONORRHOEAE; GONOCOCCAL INFECTIONS; TREATMENT FAILURE; NO LONGER; SUSCEPTIBILITY; CEFTRIAXONE; CEFIXIME; CEPHALOSPORINS; CIPROFLOXACIN AB Background: Replacing oral treatments with ceftriaxone is a central component of public health efforts to slow the emergence of cephalosporin-resistant Neisseria gonorrhoeae in the United States; US gonorrhea treatment guidelines were revised accordingly in 2010. However, current US gonorrhea treatment practices have not been well characterized. Methods: Six city and state health departments in Cycle II of the STD Surveillance Network (SSuN) contributed data on all gonorrhea cases reported in 101 counties and independent cities. Treatment data were obtained through local public health surveillance and interviews with a random sample of patients. Cases were weighted to adjust for site-specific sample fractions and for differential nonresponse by age, sex, and provider type. Results: From 2010 to 2012, 135,984 gonorrhea cases were reported in participating areas, 15,246 (11.2%) of which were randomly sampled. Of these, 7,851 (51.5%) patients were interviewed. Among patients with complete treatment data, 76.8% received ceftriaxone, 16.4% received an oral cephalosporin, and 6.9% did not receive a cephalosporin; 51.9% of persons were treated with a regimen containing ceftriaxone and either doxycycline or azithromycin. Ceftriaxone treatment increased significantly by year (64.1% of patients in 2010, 79.3% in 2011, 85.4% in 2012; P = 0.0001). Ceftriaxone use varied widely by STD Surveillance Network site (from 44.6% to 95.1% in 2012). Conclusions: Most persons diagnosed as having gonorrhea between 2010 and 2012 in the United States received ceftriaxone, and its use has increased since the release of the 2010 Centers for Disease Control and Prevention STD Treatment Guidelines. C1 [Kerani, Roxanne P.; Golden, Matthew] Publ Hlth Seattle & King Cty, Seattle, WA USA. [Kerani, Roxanne P.; Golden, Matthew] Univ Washington, Ctr AIDS & STD, Seattle, WA 98104 USA. [Stenger, Mark R.; Weinstock, Hillard] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Bernstein, Kyle T.] Dept Publ Hlth, San Francisco, CA USA. [Reed, Mary] Colorado Dept Publ Hlth & Environm, Denver, CO USA. [Schumacher, Christina] Baltimore City Dept Hlth, Baltimore, MD USA. [Schumacher, Christina] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Samuel, Michael C.] Calif Dept Publ Hlth, Richmond, CA USA. [Eaglin, Margaret] Chicago Dept Publ Hlth, Chicago, IL USA. RP Kerani, RP (reprint author), Univ Washington, Harborview Med Ctr, Ctr AIDS & STD, Box 359931,325 9th Ave, Seattle, WA 98104 USA. EM rkerani@uw.edu FU STD Surveillance Network [PS08-865] FX This work was supported through a cooperative agreement (STD Surveillance Network, PS08-865) with the US Centers for Disease Control and Prevention. The authors declare no conflicts of interest. NR 32 TC 7 Z9 7 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2015 VL 42 IS 1 BP 6 EP 12 DI 10.1097/OLQ.0000000000000217 PG 7 WC Infectious Diseases SC Infectious Diseases GA AW6ED UT WOS:000346361300004 PM 25504294 ER PT J AU Liu, G Hariri, S Bradley, H Gottlieb, SL Leichliter, JS Markowitz, LE AF Liu, Gui Hariri, Susan Bradley, Heather Gottlieb, Sami L. Leichliter, Jami S. Markowitz, Lauri E. TI Trends and Patterns of Sexual Behaviors Among Adolescents and Adults Aged 14 to 59 Years, United States SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID HIGH-SCHOOL-STUDENTS; TRANSMITTED INFECTIONS; RACIAL DISPARITIES; RISK BEHAVIORS; SECULAR TRENDS; YOUNG-ADULTS; HEALTH; PREVALENCE; NETWORKS; HIV AB Background: Evaluation of sexual behaviors is essential to better understand the epidemiology of sexually transmitted infections and their sequelae. Methods: The National Health and Nutrition Examination Surveys (NHANES) is an ongoing probability sample survey of the US population. Using NHANES sexual behavior data from 1999 to 2012, we performed the following: (1) trend analyses among adults aged 25 to 59 years by 10-year birth cohorts and (2) descriptive analyses among participants aged 14 to 24 years. Sex was defined as vaginal, anal, or oral sex. Results: Among adults aged 25 to 59 years, median age at sexual initiation decreased between the 1940-1949 and 1980-1989 cohorts from 17.9 to 16.2 among females (P-trend < 0.001) and from 17.1 to 16.1 among males (P-trend < 0.001). Median lifetime partners increased between the 1940-1949 and 1970-1979 cohorts, from 2.6 to 5.3 among females (P-trend < 0.001) and from 6.7 to 8.8 among males (P-trend < 0.001). The percentage of females reporting ever having a same-sex partner increased from 5.2% to 9.3% between the 1940-1949 and 1970-1979 cohorts (P-trend < 0.001). Among participants aged 14 to 24 years, the percentage having had sex increased with age, from 12.5% among females and 13.1% among males at age 14 years to more than 75% at age 19 years for both sexes. Among sexually experienced 14- to 19-year-olds, 45.2% of females and 55.0% of males had at least 3 lifetime partners; 39.4% of females and 48.6% of males had at least 2 partners in the past year. The proportion of females aged 20 to 24 years who reported ever having a same-sex partner was 14.9%. The proportion of participants aged 14-19 or 20-24 years reporting ever having sex did not differ by survey year from 1999 to 2012 for either males or females. Conclusions: Sexual behaviors changed with successive birth cohorts, with more pronounced changes among females. A substantial proportion of adolescents are sexually active and have multiple partners. These data reinforce existing recommendations for sexual health education and sexually transmitted infection prevention targeting adolescents before sexual debut. C1 [Liu, Gui; Hariri, Susan; Gottlieb, Sami L.; Leichliter, Jami S.; Markowitz, Lauri E.] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA 30333 USA. [Bradley, Heather] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Liu, G (reprint author), Ctr Dis Control & Prevent, Epidemiol & Stat Branch, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, 1600 Clifton Rd NE,MS E-02, Atlanta, GA 30333 USA. EM wrf8@cdc.gov NR 29 TC 16 Z9 16 U1 1 U2 15 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 EI 1537-4521 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JAN PY 2015 VL 42 IS 1 BP 20 EP 26 DI 10.1097/OLQ.0000000000000231 PG 7 WC Infectious Diseases SC Infectious Diseases GA AW6ED UT WOS:000346361300006 PM 25504296 ER PT J AU Yusuf, HR Hooper, WC Grosse, SD Parker, CS Boulet, SL Ortel, TL AF Yusuf, Hussain R. Hooper, W. Craig Grosse, Scott D. Parker, Christopher S. Boulet, Sheree L. Ortel, Thomas L. TI Risk of venous thromboembolism occurrence among adults with selected autoimmune diseases: A study among a U.S. cohort of commercial insurance enrollees SO THROMBOSIS RESEARCH LA English DT Article DE Autoimmune diseases; Autoimmune hemolytic anemia; Immune thrombocytopenic purpura; Rheumatoid arthritis; Systemic lupus erythematosus; Venous thromboembolism ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; DEEP-VEIN THROMBOSIS; RHEUMATOID-ARTHRITIS; PULMONARY-EMBOLISM; CLAIMS DATA; ADMINISTRATIVE DATA; VALIDATED METHODS; ANTICOAGULANT; ARTERIAL; EVENTS AB Objective: This study assessed the risk of venous thromboembolism (VTE) among privately insured adults in the U.S. with one or more of the following autoimmune diseases: autoimmune hemolytic anemia (AIHA), immune thrombocytopenic purpura (ITP), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). Materials and Methods: Using the Truven Health MarketScan(R) Databases, patients 18-64 years of age with a diagnosis of AIHA, ITP, RA, or SLE in 2007 and a sex and age-group matched comparison group of enrollees were followed up through 2010 to identify VTE events. Survival curve and Cox proportional hazards analyses were conducted to assess differences between groups. Results: Among patients with AIHA, ITP, RA, or SLE, or > 1 of these diseases, the risk of at least one VTE event was 19.74, 7.72, 4.90, 9.89, and 13.35 per 1,000 person-years, respectively; among the comparison group, the risk was 1.91 per 1,000 person-years. The adjusted hazard ratios (aHRs) for VTE among patients with AIHA, ITP, RA, or SLE, or > 1 of these diseases (when compared with the comparison group) tended to decline over follow-up time; at 1 year, the aHRs were 6.30 (95% confidence interval [CI]: 4.44-8.94), 2.95 (95% CI: 2.18-4.00), 2.13 (95% CI: 1.89-2.40), 4.68 (95% CI: 4.10-5.33), and 5.11 (95% CI: 4.26-6.14), respectively. Conclusion: Having AIHA, ITP, RA, or SLE, or > 1 of these diseases was associated with an increased likelihood of a VTE event. More research is necessary to develop better understanding of VTE occurrence among people with autoimmune diseases. Published by Elsevier Ltd. C1 [Yusuf, Hussain R.] Ctr Dis Control & Prevent, Off Sci & Publ Hlth Practice, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. [Hooper, W. Craig; Grosse, Scott D.; Parker, Christopher S.] Ctr Dis Control & Prevent, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Boulet, Sheree L.] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [Ortel, Thomas L.] Duke Univ, Med Ctr, Ctr Thrombosis & Hemostasis, Durham, NC 27710 USA. RP Yusuf, HR (reprint author), CDC, Off Sci & Publ Hlth Practice, OPHPR, 1600 Clifton Rd NE,MS-K72, Atlanta, GA 30333 USA. EM hyusuf@cdc.gov FU Intramural CDC HHS [CC999999] NR 35 TC 16 Z9 16 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0049-3848 J9 THROMB RES JI Thromb. Res. PD JAN PY 2015 VL 135 IS 1 BP 50 EP 57 DI 10.1016/j.thromres.2014.10.012 PG 8 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA AW7GK UT WOS:000346432600010 PM 25456001 ER PT J AU Babb, S McNeil, C Kruger, J Tynan, MA AF Babb, Stephen McNeil, Carrie Kruger, Judy Tynan, Michael A. TI Secondhand smoke and smoking restrictions in casinos: a review of the evidence SO TOBACCO CONTROL LA English DT Review ID ENVIRONMENTAL TOBACCO-SMOKE; HIGHLY EXPOSED WORKFORCE; FREE LAW; 2ND-HAND SMOKE; AFFECT REVENUE; DELAWARE; WORKERS; HEALTH; AIR; GAMBLERS AB Objective There is no safe level of secondhand smoke (SHS) exposure. Most US casinos continue to allow smoking, thus exposing workers and patrons to the hazards of SHS. This paper reviews the scientific literature on air quality, SHS exposure, health effects and economic outcomes related to SHS and smoking restrictions in casinos, as well as on smoking prevalence among casino patrons and problem gamblers. Data sources Peer reviewed studies published from January 1998 to March 2011. Data synthesis Evidence from air quality, biomarker and survey studies indicates that smoking in casinos is a significant public health problem. Workers and patrons in casinos that allow smoking are exposed to high levels of SHS, as documented by elevated levels of SHS constituents in the air of casinos and by elevated levels of tobacco-specific biomarkers in non-smokers' blood, urine and saliva. Partial smoking restrictions in casinos do not effectively protect non-smokers from SHS. Findings suggest that the smoking prevalence of casino patrons is comparable with that of the general public, although this prevalence may be higher among problem gamblers. Few studies have examined the economic impact of smoke-free policies in casinos, and the results of these studies are mixed. Conclusions Employees and patrons are exposed to SHS in casinos, posing a significant, preventable risk to their health. Policies completely prohibiting smoking in casinos would be expected to greatly reduce or eliminate SHS exposure in casinos, thereby protecting the health of casino workers and patrons. C1 [Babb, Stephen; Kruger, Judy; Tynan, Michael A.] Ctr Dis Control & Prevent, Off Smoking & Hlth, Atlanta, GA 30341 USA. [McNeil, Carrie] Emory Univ, Rollins Sch Publ Hlth, Global Environm Hlth Dept, Atlanta, GA 30322 USA. RP Babb, S (reprint author), Ctr Dis Control & Prevent, Off Smoking & Hlth, 4770 Buford Highway NE,Mailstop F-79, Atlanta, GA 30341 USA. EM zur4@cdc.gov NR 53 TC 6 Z9 6 U1 0 U2 6 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0964-4563 EI 1468-3318 J9 TOB CONTROL JI Tob. Control PD JAN PY 2015 VL 24 IS 1 BP 11 EP 17 DI 10.1136/tobaccocontrol-2013-051368 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AW4PX UT WOS:000346264200010 PM 24610051 ER PT J AU Nelson, DE Pederson, LL Mowery, P Bailey, S Sevilimedu, V London, J Babb, S Pechacek, T AF Nelson, David E. Pederson, Linda L. Mowery, Paul Bailey, Sarah Sevilimedu, Varadan London, Joel Babb, Stephen Pechacek, Terry TI Trends in US newspaper and television coverage of tobacco SO TOBACCO CONTROL LA English DT Article ID MEDIA ADVOCACY; CONTROL ISSUES; NEWS MEDIA; SMOKING AB Purpose The news media plays an important role in agenda setting and framing of stories about tobacco control. The purpose of this study was to examine newspaper, newswire and television coverage of tobacco issues in the USA over a 7-year period. Methods Analyses of 2004-2010 news media surveillance system data from the US Centers for Disease Control and Prevention's Office on Smoking and Health, based on content analysis and quantitative methods. Information on extent of news coverage, and types of tobacco-related themes, were examined from articles in 10 newspapers and 2 major newswires, as well as transcripts from 6 national television networks. Results The overall extent of newspaper, newswire and television stories about tobacco, and level of coverage by specific media outlets, varied over time, especially for newspapers. Nevertheless, there was an average of 3 newspaper stories, 4 newswire stories, and 1 television tobacco-related story each day. Television stories were more likely to contain cessation/addiction or health effects/statistics themes and less likely to contain secondhand smoke or policy/regulation themes than newspaper/newswire stories. There was more variation in the choice of tobacco theme among individual newspapers/newswires than television media outlets. Conclusions News coverage of tobacco in the USA was relatively constant from 2004 to 2010. Audiences were more likely to be exposed to different tobacco themes in newspapers/newswires than on television. Tracking information about tobacco news stories can be used by advocates, programs and others for planning and evaluation, and by researchers for hypothesis generation. C1 [Nelson, David E.] NCI, Canc Prevent Fellowship Program, Canc Prevent Div, Bethesda, MD 20892 USA. [Pederson, Linda L.] McKing Consulting Corp, Atlanta, GA USA. [Mowery, Paul; Sevilimedu, Varadan] Biostatistics Inc, Atlanta, GA USA. [Bailey, Sarah; London, Joel; Babb, Stephen; Pechacek, Terry] Ctr Dis Control & Prevent, Off Smoking & Hlth, Natl Ctr Chron Dis & Hlth Promot, Atlanta, GA USA. RP Nelson, DE (reprint author), 9609 Med Ctr Dr,Suite 2W-138,MSC 9712, Bethesda, MD 20892 USA. EM nelsonde@mail.nih.gov NR 24 TC 2 Z9 2 U1 0 U2 5 PU BMJ PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0964-4563 EI 1468-3318 J9 TOB CONTROL JI Tob. Control PD JAN PY 2015 VL 24 IS 1 BP 94 EP 99 DI 10.1136/tobaccocontrol-2013-050963 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AW4PX UT WOS:000346264200022 PM 23864404 ER PT J AU Deng, XY Shariat, N Driebe, EM Roe, CC Tolar, B Trees, E Keim, P Zhang, W Dudley, EG Fields, PI Engelthaler, DM AF Deng, Xiangyu Shariat, Nikki Driebe, Elizabeth M. Roe, Chandler C. Tolar, Beth Trees, Eija Keim, Paul Zhang, Wei Dudley, Edward G. Fields, Patricia I. Engelthaler, David M. TI Comparative Analysis of Subtyping Methods against a Whole-Genome-Sequencing Standard for Salmonella enterica Serotype Enteritidis SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID FIELD GEL-ELECTROPHORESIS; TANDEM REPEAT ANALYSIS; VARIABLE-NUMBER; UNITED-STATES; SEROVAR ENTERITIDIS; ESCHERICHIA-COLI; CRISPR-MVLST; OUTBREAK; SURVEILLANCE; EVOLUTIONARY AB A retrospective investigation was performed to evaluate whole-genome sequencing as a benchmark for comparing molecular subtyping methods for Salmonella enterica serotype Enteritidis and survey the population structure of commonly encountered S. enterica serotype Enteritidis outbreak isolates in the United States. A total of 52 S. enterica serotype Enteritidis isolates representing 16 major outbreaks and three sporadic cases collected between 2001 and 2012 were sequenced and subjected to subtyping by four different methods: (i) whole-genome single-nucleotide-polymorphism typing (WGST), (ii) multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA), (iii) clustered regularly interspaced short palindromic repeats combined with multi-virulence-locus sequence typing (CRISPR-MVLST), and (iv) pulsed-field gel electrophoresis (PFGE). WGST resolved all outbreak clusters and provided useful robust phylogenetic inference results with high epidemiological correlation. While both MLVA and CRISPR-MVLST yielded higher discriminatory power than PFGE, MLVA outperformed the other methods in delineating outbreak clusters whereas CRISPR-MVLST showed the potential to trace major lineages and ecological origins of S. enterica serotype Enteritidis. Our results suggested that whole-genome sequencing makes a viable platform for the evaluation and benchmarking of molecular subtyping methods. C1 [Deng, Xiangyu] Univ Georgia, Dept Food Sci & Technol, Ctr Food Safety, Griffin, GA 30223 USA. [Shariat, Nikki; Dudley, Edward G.] Penn State Univ, Dept Food Sci, University Pk, PA 16802 USA. [Driebe, Elizabeth M.; Roe, Chandler C.; Keim, Paul; Engelthaler, David M.] Translat Genom Res Inst, Flagstaff, AZ USA. [Tolar, Beth; Trees, Eija; Fields, Patricia I.] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA USA. [Keim, Paul] No Arizona Univ, Flagstaff, AZ 86011 USA. [Zhang, Wei] Illinois Inst Technol, Inst Food Safety & Hlth, Bedford Pk, IL USA. [Dudley, Edward G.] Penn State Univ, Ctr Mol Immunol & Infect Dis, University Pk, PA 16802 USA. RP Deng, XY (reprint author), Univ Georgia, Dept Food Sci & Technol, Ctr Food Safety, Griffin, GA 30223 USA. EM xdeng@uga.edu FU University of Georgia; United States Army Research Office [W911NF-11-1-0442] FX This work was supported in part by University of Georgia startup funds to X.D. and a United States Army Research Office grant (W911NF-11-1-0442) to E.G.D. NR 40 TC 14 Z9 14 U1 1 U2 19 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 EI 1098-660X J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 2015 VL 53 IS 1 BP 212 EP 218 DI 10.1128/JCM.02332-14 PG 7 WC Microbiology SC Microbiology GA AW8HM UT WOS:000346502200032 PM 25378576 ER PT J AU Joo, H Fang, J Losby, JL Wang, GJ AF Joo, Heesoo Fang, Jing Losby, Jan L. Wang, Guijing TI Cost of informal caregiving for patients with heart failure SO AMERICAN HEART JOURNAL LA English DT Article ID STROKE SURVIVORS; ELDERLY ADULTS; UNITED-STATES; CARE; HOSPITALIZATION; RACE; ASSOCIATION; DISABILITY; AMERICANS; QUANTITY AB Background Heart failure is a serious health condition that requires a significant amount of informal care. However, informal caregiving costs associated with heart failure are largely unknown. Methods We used a study sample of noninstitutionalized US respondents aged >= 50 years from the 2010 HRS (n = 19,762). Heart failure cases were defined by using self-reported information. The weekly informal caregiving hours were derived by a sequence of survey questions assessing (1) whether respondents had any difficulties in activities of daily living or instrumental activities of daily living, (2) whether they had caregivers because of reported difficulties, (3) the relationship between the patient and the caregiver, (4) whether caregivers were paid, and (5) how many hours per week each informal caregiver provided help. We used a 2-part econometric model to estimate the informal caregiving hours associated with heart failure. The first part was a logit model to estimate the likelihood of using informal caregiving, and the second was a generalized linear model to estimate the amount of informal caregiving hours used among those who used informal caregiving. Replacement approach was used to estimate informal caregiving cost. Results The 943 (3.9%) respondents who self-reported as ever being diagnosed with heart failure used about 1.6 more hours of informal caregiving per week than those who did not have heart failure (P < .001). Informal caregiving hours associated with heart failure were higher among non-Hispanic blacks (3.9 hours/week) than non-Hispanic whites (1.4 hours/week). The estimated annual informal caregiving cost attributable to heart failure was $3 billion in 2010. Conclusion The cost of informal caregiving was substantial and should be included in estimating the economic burden of heart failure. The results should help public health decision makers in understanding the economic burden of heart failure and in setting public health priorities. C1 [Joo, Heesoo; Fang, Jing; Losby, Jan L.; Wang, Guijing] Ctr Dis Control & Prevent CDC, Div Heart Dis & Stroke Prevent, Atlanta, GA USA. RP Wang, GJ (reprint author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, 4770 Buford Hwy NE,Mailstop F-72, Atlanta, GA 30341 USA. EM gbw9@cdc.gov OI Joo, Heesoo/0000-0002-1342-6428 FU Intramural CDC HHS [CC999999] NR 26 TC 2 Z9 2 U1 1 U2 10 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-8703 EI 1097-5330 J9 AM HEART J JI Am. Heart J. PD JAN PY 2015 VL 169 IS 1 BP 142 EP + DI 10.1016/j.ahj.2014.10.010 PG 9 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AW2NE UT WOS:000346124400021 PM 25497259 ER PT J AU Lu, ML Waters, T Werren, D AF Lu, Ming-Lun Waters, Thomas Werren, Dwight TI Development of Human Posture Simulation Method for Assessing Posture Angles and Spinal Loads SO HUMAN FACTORS AND ERGONOMICS IN MANUFACTURING & SERVICE INDUSTRIES LA English DT Article DE Manual lifting; Human posture simulation; Three-dimensional static strength prediction program; Biomechanical model; Observational method ID LINKED SEGMENT MODEL; LOW-BACK DISORDERS; RISK-FACTORS; MUSCULOSKELETAL DISORDERS; INTERRATER RELIABILITY; WORK; PAIN; VALIDATION; EXPOSURE; PERCEPTION AB Video-based posture analysis employing a biomechanical model is gaining a growing popularity for ergonomic assessments. A human posture simulation method of estimating multiple body postural angles and spinal loads from a video record was developed to expedite ergonomic assessments. The method was evaluated by a repeated measures study design with three trunk flexion levels, two lift asymmetry levels, three viewing angles, and three trial repetitions as experimental factors. The study comprised two phases evaluating the accuracy of simulating self- and other people's lifting posture via a proxy of a computer-generated humanoid. The mean values of the accuracy of simulating self- and humanoid postures were 12 degrees and 15 degrees, respectively. The repeatability of the method for the same lifting condition was excellent (approximate to 2 degrees). The least simulation error was associated with side viewing angle. The estimated back compressive force and moment, calculated by a three-dimensional biomechanical model, exhibited a range of 5% underestimation. The posture simulation method enables researchers to quantify simultaneously body posture angles and spinal loading variables with accuracy and precision comparable to on-screen posture-matching methods. C1 [Lu, Ming-Lun; Waters, Thomas; Werren, Dwight] NIOSH, Taft Labs, Cincinnati, OH 45226 USA. RP Lu, ML (reprint author), NIOSH, 4676 Columbia Pkwy MS C-24, Cincinnati, OH 45226 USA. EM mlu@cdc.gov FU Intramural CDC HHS [CC999999] NR 49 TC 1 Z9 1 U1 4 U2 14 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1090-8471 EI 1520-6564 J9 HUM FACTOR ERGON MAN JI Hum. Factors Ergonom. Manuf. Serv. Ind. PD JAN-FEB PY 2015 VL 25 IS 1 BP 123 EP 136 DI 10.1002/hfm.20534 PG 14 WC Engineering, Manufacturing; Ergonomics SC Engineering GA AW1FD UT WOS:000346034900009 PM 26361435 ER PT J AU Ambeba, EJ Ye, L Sereika, SM Styn, MA Acharya, SD Sevick, MA Ewing, LJ Conroy, MB Glanz, K Zheng, YG Goode, RW Mattos, M Burke, LE AF Ambeba, Erica J. Ye, Lei Sereika, Susan M. Styn, Mindi A. Acharya, Sushama D. Sevick, Mary Ann Ewing, Linda J. Conroy, Molly B. Glanz, Karen Zheng, Yaguang Goode, Rachel W. Mattos, Meghan Burke, Lora E. TI The Use of mHealth to Deliver Tailored Messages Reduces Reported Energy and Fat Intake SO JOURNAL OF CARDIOVASCULAR NURSING LA English DT Article DE behavior change; dietary intake; mHealth; tailored feedback ID RANDOMIZED-CONTROLLED-TRIAL; LIFE-STYLE MODIFICATION; MULTIPLE-PASS METHOD; WEIGHT-LOSS; DIETARY ASSESSMENT; PROGRAM; TECHNOLOGY; INTERVENTIONS; MANAGEMENT; ADHERENCE AB Background: Evidence supports the role of feedback in reinforcing motivation for behavior change. Feedback that provides reinforcement has the potential to increase dietary self-monitoring and enhance attainment of recommended dietary intake. Objective: The aim of this study was to examine the impact of daily feedback (DFB) messages, delivered remotely, on changes in dietary intake. Methods: This was a secondary analysis of the Self-Monitoring And Recording using Technology (SMART) Trial, a single-center, 24-month randomized clinical trial of behavioral treatment for weight loss. Participants included 210 obese adults (mean body mass index, 34.0 kg/m(2)) who were randomized to either a paper diary (PD), personal digital assistant (PDA), or PDA plus daily tailored feedback messages (PDA + FB). To determine the role of daily tailored feedback in dietary intake, we compared the self-monitoring with DFB group (DFB group; n = 70) with the self-monitoring without DFB group (no-DFB group, n = 140). All participants received a standard behavioral intervention for weight loss. Self-reported changes in dietary intake were compared between the DFB and no-DFB groups and were measured at baseline and at 6, 12, 18, and 24 months. Linear mixed modeling was used to examine percentage changes in dietary intake from baseline. Results: Compared with the no-DFB group, the DFB group achieved a larger reduction in energy (-22.8% vs -14.0%; P = .02) and saturated fat (-11.3% vs -0.5%; P = .03) intake and a trend toward a greater decrease in total fat intake (-10.4% vs -4.7%; P = .09). There were significant improvements over time in carbohydrate intake and total fat intake for both groups (P values < .05). Conclusion: Daily tailored feedback messages designed to target energy and fat intake and delivered remotely in real time using mobile devices may play an important role in the reduction of energy and fat intake. C1 [Ambeba, Erica J.; Ye, Lei; Sereika, Susan M.; Styn, Mindi A.; Glanz, Karen; Burke, Lora E.] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA. [Ambeba, Erica J.; Ye, Lei; Sereika, Susan M.; Styn, Mindi A.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Hlth & Community Syst, Pittsburgh, PA 15261 USA. [Ambeba, Erica J.; Styn, Mindi A.; Conroy, Molly B.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA. [Ye, Lei; Sereika, Susan M.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USA. [Acharya, Sushama D.] Ctr Dis Control & Prevent, Community Guide Branch, Off Surveillance Epidemiol & Lab Serv, Epidemiol & Anal Program Off, Atlanta, GA USA. [Sevick, Mary Ann] Veteran Affairs Pittsburgh Healthcare Syst, Pittsburgh, PA USA. [Sevick, Mary Ann] Univ Pittsburgh, Sch Med, Dept Med, Ctr Res Healthcare, Pittsburgh, PA 15261 USA. [Ewing, Linda J.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15261 USA. [Conroy, Molly B.; Glanz, Karen] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15261 USA. [Conroy, Molly B.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Med, Pittsburgh, PA 15261 USA. [Zheng, Yaguang; Mattos, Meghan] Univ Pittsburgh, Sch Nursing, Dept Hlth & Community Syst, Pittsburgh, PA 15261 USA. [Goode, Rachel W.] Univ Pittsburgh, Sch Social Work, Pittsburgh, PA 15261 USA. [Goode, Rachel W.; Burke, Lora E.] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA. RP Burke, LE (reprint author), Univ Pittsburgh, Sch Nursing, 415 Victoria Bldg,3500 Victoria St, Pittsburgh, PA 15261 USA. EM lbu100@pitt.edu FU National Institutes of Health [RO1-DK71817]; NIH [NR010742]; Data Management Core of the Center for Research in Chronic Disorders [NIH-NINR P30-NR03924]; General Clinical Research Center [NIH-NCRR-GCRC 5MO1-RR00056]; Clinical Translational Research Center (NIH/NCRR/CTSA) at the University of Pittsburgh [UL1 RR024153] FX This study was supported by National Institutes of Health grant RO1-DK71817 and partial support for L.E.B. by NIH K24 Award NR010742. The conduct of the study was also supported by the Data Management Core of the Center for Research in Chronic Disorders (NIH-NINR P30-NR03924) and the General Clinical Research Center (NIH-NCRR-GCRC 5MO1-RR00056) and the Clinical Translational Research Center (NIH/NCRR/CTSA grant UL1 RR024153) at the University of Pittsburgh. NR 38 TC 9 Z9 9 U1 2 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0889-4655 EI 1550-5049 J9 J CARDIOVASC NURS JI J. Cardiovasc. Nurs. PD JAN-FEB PY 2015 VL 30 IS 1 BP 35 EP 43 DI 10.1097/JCN.0000000000000120 PG 9 WC Cardiac & Cardiovascular Systems; Nursing SC Cardiovascular System & Cardiology; Nursing GA AW2LS UT WOS:000346120100014 PM 24434827 ER PT J AU Bejarano, EE Uribe, SI Perez-Doria, A Egurrola, J Dib, JC Porter, CH AF Elias Bejarano, Eduar Ines Uribe, Sandra Perez-Doria, Alveiro Egurrola, Jorge Carlos Dib, Juan Porter, Charles H. TI New Records of Phlebotomine Sand Flies (Diptera: Psychodidae) at Sierra Nevada de Santa Marta, Colombia SO ACTA BIOLOGICA COLOMBIANA LA Spanish DT Article AB Phlebotomine sand flies, vectors of leishmaniasis, have not been well studied in the Sierra Nevada de Santa Marta, and likewise, are not well known in other regions of the Department of Magdalena, Colombia. To date only thirteen species of Lutzomyia have been recorded as occurring in the Department. The present note adds three species and includes an additional subgenus. Collections were made in the lower foothills of the Sierra Nevada de Santa Marta at elevations ranging from 117-130 m in the communities of Seywiaka, Las Tinajas and Calabazo. Eighty-four percent of the 885 phlebotomines sand flies collected were obtained from CDC light traps, 11 % from Shannon trap and 5 % from typical resting sites using an electric aspirator. The following nine species were identified from the collections: Lutzomyia gomezi, Lu. panamensis, Lu. trinidadensis, Lu. carpenteri, Lu. evansi, Lu. dysponeta, Lu. dubitans, Lu. shannoni, and Lu. micropyga. The most abundant species were Lu. gomezi and Lu. panamensis, which, respectively, accounted for 69 % and 14 % of the specimens. Of the nine species, Lu. carpenteri, Lu. dubitans and Lu. dysponeta represent new records for the Department of Magdalena. Also, a few female specimens were encountered of a species belonging to the Lu. osornoi series of the subgenus Helcocyrtomyia, which represents the first record of this subgenus in the Caribbean region of Colombia. C1 [Elias Bejarano, Eduar; Perez-Doria, Alveiro] Univ Sucre, Biomed Labs, Grp Invest Biomed, Sincelejo, Colombia. [Ines Uribe, Sandra] Univ Nacl Colombia, Grp Sistemat Mol, Sede Medellin, Medellin, Colombia. [Egurrola, Jorge] Fdn Salud & Trop, Ctr Invest Enfermedades Trop CIET, Santa Marta, Colombia. [Egurrola, Jorge; Carlos Dib, Juan] Corp Univ Remington, Fac Ciencias Salud, Grp Salud Familiar & Comunitaria GISAFACO, Medellin, Colombia. [Porter, Charles H.] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, CDC, Atlanta, GA USA. RP Bejarano, EE (reprint author), Univ Sucre, Biomed Labs, Grp Invest Biomed, Carrera 14 16B-32, Sincelejo, Colombia. EM eduarelias@yahoo.com NR 0 TC 2 Z9 2 U1 0 U2 0 PU UNIV NAC COLOMBIA, FAC CIENCIAS, DEPT BIOL PI BOGOTA PA APARTADO AEREO 14490, BOGOTA, 00000, COLOMBIA SN 0120-548X EI 1900-1649 J9 ACTA BIOL COLOMB JI Acta Biol. Colomb. PD JAN-APR PY 2015 VL 20 IS 1 BP 221 EP 224 PG 4 WC Plant Sciences; Zoology SC Plant Sciences; Zoology GA CC3UE UT WOS:000350274800023 ER PT J AU Maslia, ML AF Maslia, Morris L. BE Karvazy, K Webster, VL TI Application of Water-Modeling Tools to Reconstruct Historical Drinking Water Contaminant Concentrations for Epidemiological Studies SO World Environmental and Water Resources Congress 2015: Floods, Droughts, and Ecosystems LA English DT Proceedings Paper CT World Environmental and Water Resources Congress CY MAY 17-21, 2015 CL Austin, TX SP Amer Soc Civil Engineers, Environm and Water Resources Inst ID LONDON CHOLERA EPIDEMIC AB Contamination of public drinking water and the resulting health consequences have been documented for several centuries. When such occurrences take place, scientists and public health officials require water distribution systems analysis to identify the source(s), duration, and frequency of the contamination. This information is then used to characterize and quantify the public's exposure to contaminants in drinking water. Typically, studies conducted by health scientists and epidemiologists related to exposure to water-distribution system contamination are retrospective in nature- reconstructing the contamination event(s) in order to document exposure and health impacts. Four historical cases will be used to illustrate the application of water-distribution systems analysis for supporting public health investigations: (1) the 1854 cholera outbreak in London, England, (2) childhood leukemia investigation, Woburn, Massachusetts, (3) childhood cancer cluster investigation, Dover Township (Toms River), New Jersey, and (4) volatile organic compound contamination of drinking water, U.S. Marine Corps Base Camp Lejeune, North Carolina. These four historical and high-profile public health cases demonstrate the contributions of water-distribution systems analysis to epidemiological investigations and to quantifying the public's exposure to contaminated drinking water. C1 [Maslia, Morris L.] Agcy Tox Subst & Dis Registry, Div Community Hlth Invest, 4770 Buford Highway,MS F-59, Atlanta, GA 30341 USA. RP Maslia, ML (reprint author), Agcy Tox Subst & Dis Registry, Div Community Hlth Invest, 4770 Buford Highway,MS F-59, Atlanta, GA 30341 USA. EM mmaslia@cdc.gov NR 15 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CIVIL ENGINEERS PI NEW YORK PA UNITED ENGINEERING CENTER, 345 E 47TH ST, NEW YORK, NY 10017-2398 USA BN 978-0-7844-7916-2 PY 2015 BP 658 EP 668 PG 11 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA BG8ZE UT WOS:000392856300061 ER PT J AU Wang, DX Krilich, J Baudys, J Barr, JR Kalb, SR AF Wang, Dongxia Krilich, Joan Baudys, Jakub Barr, John R. Kalb, Suzanne R. TI Optimization of peptide substrates for botulinum neurotoxin E improves detection sensitivity in the Endopep-MS assay SO ANALYTICAL BIOCHEMISTRY LA English DT Article DE Botulinum neurotoxin; Botulism; Mass spectrometry; Peptide substrate ID MASS-SPECTROMETRY; SEROTYPE-E; PROTEOLYSIS; SNAP-25; RECOGNITION; CLEAVAGE; SNAP25; TOXIN; SITE AB Botulinum neurotoxins (BoNTs) produced by Clostridium botulinum are the most poisonous substances known to humankind. It is essential to have a simple, quick, and sensitive method for the detection and quantification of botulinum toxin in various media, including complex biological matrices. Our laboratory has developed a mass spectrometry-based Endopep-MS assay that is able to rapidly detect and differentiate all types of BoNTs by extracting the toxin with specific antibodies and detecting the unique cleavage products of peptide substrates. Botulinum neurotoxin type E (BoNT/E) is a member of a family of seven distinctive BoNT serotypes (A-G) and is the causative agent of botulism in both humans and animals. To improve the sensitivity of the Endopep-MS assay, we report here the development of novel peptide substrates for the detection of BoNT/E activity through systematic and comprehensive approaches. Our data demonstrate that several optimal peptides could accomplish 500-fold improvement in sensitivity compared with the current substrate for the detection of both not-trypsin-activated and trypsin-activated BoNT/E toxin complexes. A limit of detection of 0.1 mouse LD50/ml was achieved using the novel peptide substrate in the assay to detect not-trypsin-activated BoNT/E complex spiked in serum, stool, and food samples. Published by Elsevier Inc. C1 [Wang, Dongxia; Baudys, Jakub; Barr, John R.; Kalb, Suzanne R.] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. [Krilich, Joan] Ctr Dis Control & Prevent, Battelle Mem Inst Contract, Atlanta, GA 30341 USA. RP Kalb, SR (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30341 USA. EM skalb@cdc.gov FU Intramural CDC HHS [CC999999] NR 27 TC 4 Z9 4 U1 2 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 EI 1096-0309 J9 ANAL BIOCHEM JI Anal. Biochem. PD JAN 1 PY 2015 VL 468 BP 15 EP 21 DI 10.1016/j.ab.2014.08.026 PG 7 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA AU7XN UT WOS:000345811800003 PM 25232998 ER PT J AU Hatcher, MT AF Hatcher, Michael T. TI A Commentary on Drivers of Community Health Needs Assessment SO JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE LA English DT Editorial Material C1 Agcy Tox Subst & Dis Registry, Div Toxicol & Human Hlth Sci, Atlanta, GA 30341 USA. RP Hatcher, MT (reprint author), Agcy Tox Subst & Dis Registry, Div Toxicol & Human Hlth Sci, 4770 Buford Hwy,NE Mail Stop F-57, Atlanta, GA 30341 USA. EM MHatcher@cdc.gov NR 9 TC 0 Z9 0 U1 4 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1078-4659 EI 1550-5022 J9 J PUBLIC HEALTH MAN JI J. Public Health Manag. Pract. PD JAN-FEB PY 2015 VL 21 IS 1 BP 31 EP 33 DI 10.1097/PHH.0000000000000178 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AU8MZ UT WOS:000345851700010 PM 25414953 ER PT J AU Kolbe, LJ AF Kolbe, Lloyd J. TI On National Strategies to Improve Both Education and Health-An Open Letter SO JOURNAL OF SCHOOL HEALTH LA English DT Editorial Material C1 [Kolbe, Lloyd J.] Indiana Univ, Dept Appl Hlth Sci, Sch Publ Hlth Bloomington, Bloomington, IN 47405 USA. [Kolbe, Lloyd J.] US Ctr Dis Control & Prevent, Div Adolescent & Sch Hlth, Atlanta, GA 30333 USA. RP Kolbe, LJ (reprint author), 6346 Jester St, Chincoteague Isl, VA 23336 USA. EM lkolbe@indiana.edu NR 0 TC 4 Z9 4 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-4391 EI 1746-1561 J9 J SCHOOL HEALTH JI J. Sch. Health PD JAN PY 2015 VL 85 IS 1 BP 1 EP 7 DI 10.1111/josh.12223 PG 7 WC Education & Educational Research; Education, Scientific Disciplines; Health Care Sciences & Services; Public, Environmental & Occupational Health SC Education & Educational Research; Health Care Sciences & Services; Public, Environmental & Occupational Health GA AU7DP UT WOS:000345761200001 PM 25440447 ER PT J AU Wang, M Mao, WW Zhang, LL Jiang, BF Xiao, Y Jia, YJ Wu, PS Cassell, H Vermund, S AF Wang, Mei Mao, Wenwen Zhang, Linglin Jiang, Baofa Xiao, Yan Jia, Yujiang Wu, Pingsheng Cassell, Holly Vermund, Sten TI Methadone Maintenance Therapy and HIV Counseling and Testing are Associated with Lower frequency of Risky Behaviors Among Injection Drug Users in China SO SUBSTANCE USE & MISUSE LA English DT Article DE injection drug use; HIV voluntary counseling and testing; methadone maintenance treatment; needle sharing; substance use; HIV behavior; HIV prevention; sexual risk behavior ID SEXUALLY-TRANSMITTED-DISEASES; SUBSTITUTION TREATMENT; SEROCONVERSION; PREVALENCE; INFECTION; ADHERENCE; HIV/AIDS; TRANSMISSION; METAANALYSIS; PREVENTION AB Three consecutive cross-sectional surveys were conducted among injection drug users (IDUs). Of 2,530 participants, 47.7% reported ever sharing needles, 78.2% having had unprotected sex in the last month, 34.4% not receiving either methadone maintenance therapy (MMT) or HIV voluntary counseling and testing (VCT), 4.8% ever receiving MMT-only, 36.6% ever receiving VCT-only, and 24.2% ever receiving both MMT and VCT. MMT-only and the combination of MMT and VCT had significant associations with needle sharing and on unprotected sexual behaviors. Effectively integrating VCT into MMT services is a logical way to maximize the impact of both interventions on risky behaviors among IDUs. C1 [Wang, Mei; Cassell, Holly; Vermund, Sten] Vanderbilt Univ, Sch Med, Inst Global Hlth, Nashville, TN 37212 USA. [Wang, Mei] Shandong Ctr Dis Control & Prevent, Dept Sci & Res, Chengdu, Peoples R China. [Mao, Wenwen] Fengtai Dis Control & Prevent, Beijing, Peoples R China. [Zhang, Linglin] Sichuan Ctr Dis Control & Prevent, Inst AIDS STI Control & Prevent, Chengdu, Peoples R China. [Jiang, Baofa] Shandon Univ, Sch Publ Hlth, Dept Biostat & Epidemiol, Jinan, Peoples R China. [Xiao, Yan] Ctr Dis Control & Prevent, Ctr HIV AIDS Control & Prevent, Washington, DC USA. [Jia, Yujiang] Dept Hlth, Washington, DC USA. [Wu, Pingsheng] Vanderbilt Univ, Sch Med, Dept Biostat, Nashville, TN 37212 USA. [Vermund, Sten] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA. [Vermund, Sten] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA. RP Jiang, BF (reprint author), Shandong Univ, Sch Publ Hlth, Jinan, Peoples R China. EM weirzhang@vip.163.com; Bjiang@sdu.edu.cn NR 50 TC 6 Z9 6 U1 1 U2 8 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1082-6084 EI 1532-2491 J9 SUBST USE MISUSE JI Subst. Use Misuse PD JAN PY 2015 VL 50 IS 1 BP 15 EP 23 DI 10.3109/10826084.2014.957768 PG 9 WC Substance Abuse; Psychiatry; Psychology SC Substance Abuse; Psychiatry; Psychology GA AU9GK UT WOS:000345899600003 PM 25295376 ER PT J AU Magagula, NB Esona, MD Nyaga, MM Stucker, KM Halpin, RA Stockwell, TB Seheri, ML Steele, AD Wentworth, DE Mphahlele, MJ AF Magagula, Nonkululeko B. Esona, Mathew D. Nyaga, Martin M. Stucker, Karla M. Halpin, Rebecca A. Stockwell, Timothy B. Seheri, Mapaseka L. Steele, A. Duncan Wentworth, David E. Mphahlele, M. Jeffrey TI Whole Genome Analyses of G1P[8] Rotavirus Strains From Vaccinated and Non-Vaccinated South African Children Presenting With Diarrhea SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE South Africa; rotavirus G1P[8]; diarrhea stool; children; genomic analyses ID SEQUENCE-INDEPENDENT AMPLIFICATION; SEROTYPE-SPECIFIC NEUTRALIZATION; PLACEBO-CONTROLLED TRIAL; HUMAN WA-LIKE; 1ST 2 YEARS; DOUBLE-BLIND; GLYCOPROTEIN VP7; GASTROENTERITIS; GENOTYPE; DIVERSITY AB Group A rotaviruses (RVAs) are the leading cause of severe gastroenteritis and eventually death among infants and young children worldwide, and disease prevention and management through vaccination is a public health priority. In August 2009, Rotarix was introduced in the South African Expanded Programme on Immunisation. As a result, substantial reductions in RVA disease burden have been reported among children younger than 5 years old. Rotavirus strain surveillance post-vaccination is crucial to, inter alia, monitor and study the evolution of vaccine escape strains. Here, full-genome sequence data for the 11 gene segments from 11 South African G1P[8] rotavirus strains were generated, including 5 strains collected from non-vaccinated children during the 2004-2009 rotavirus seasons and 6 strains collected from vaccinated children during the 2010 rotavirus season. These data were analyzed to gain insights into the overall genetic makeup and evolution of South African G1P[8] rotavirus strains and to compare their genetic backbones with those of common human Wa-like RVAs from other countries, as well as with the Rotarix and RotaTeq G1P[8] vaccine components. All 11 South African G1P[8] strains revealed a complete Wa-like genotype constellation of G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. On the basis of sequence similarities, the South African G1P[8] strains (with the exception of strain RVA/Human-wt/ZAF/1262/2004/G1P[8]) were closely related to each other (96-100% identity in all gene segments). Comparison to the Rotarix and RotaTeq G1P[8] vaccine components revealed a moderate nucleotide identity of 89-96% and 93-95%, respectively. The results indicated that none of the gene segments of these 11 South African G1P[8] strains were vaccine-derived. This study illustrates that large-scale next generation sequencing will provide crucial information on the influence of the vaccination program on evolution of rotavirus strains. This is the first report to describe full genomic analyses of G1P[8] RVA strains collected from both non-vaccinated and vaccinated children in South Africa. J. Med. Virol. 87: 79-101, 2015. (c) 2014 Wiley Periodicals, Inc. C1 [Magagula, Nonkululeko B.; Esona, Mathew D.; Nyaga, Martin M.; Seheri, Mapaseka L.; Steele, A. Duncan; Mphahlele, M. Jeffrey] Univ Limpopo, Dept Virol, MRC, Diarrhoeal Pathogens Res Unit,Natl Hlth Lab Serv, ZA-0204 Pretoria, South Africa. [Esona, Mathew D.] CDC, Gastroenteritis & Resp Viruses Lab Branch, Div Viral Dis, NCIRD, Atlanta, GA 30333 USA. [Stucker, Karla M.; Halpin, Rebecca A.; Stockwell, Timothy B.; Wentworth, David E.] J Craig Venter Inst, Rockville, MD USA. [Steele, A. Duncan] Bill & Melinda Gates Fdn, Global Hlth Program, Enter & Diarrhoeal Dis Programme, Seattle, WA USA. RP Mphahlele, MJ (reprint author), Univ Limpopo, Dept Virol, MRC, Diarrhoeal Pathogens Res Unit, Medunsa Campus,POB 173, ZA-0204 Pretoria, South Africa. EM jeffrey.mphahlele@ul.ac.za OI Wentworth, David/0000-0002-5190-980X FU National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272200900007C]; Medical Research Council; Poliomyelitis Research Foundation of South Africa FX Grant sponsor: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services (partial support, contract number HHSN272200900007C); Grant sponsor: Medical Research Council and Poliomyelitis Research Foundation of South Africa NR 78 TC 3 Z9 3 U1 2 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0146-6615 EI 1096-9071 J9 J MED VIROL JI J. Med. Virol. PD JAN PY 2015 VL 87 IS 1 BP 79 EP 101 DI 10.1002/jmv.23971 PG 23 WC Virology SC Virology GA AT2ZG UT WOS:000344802800011 PM 24841697 ER PT J AU Hernandez, BY Goodman, MT Lynch, CF Cozen, W Unger, ER Steinau, M Thompson, T Saber, MS Altekruse, SF Lyu, C Saraiya, M AF Hernandez, Brenda Y. Goodman, Marc T. Lynch, Charles F. Cozen, Wendy Unger, Elizabeth R. Steinau, Martin Thompson, Trevor Saber, Maria Sibug Altekruse, Sean F. Lyu, Christopher Saraiya, Mona CA HPV Typing Canc Workgrp TI Human Papillomavirus Prevalence in Invasive Laryngeal Cancer in the United States SO PLOS ONE LA English DT Article ID SQUAMOUS-CELL CARCINOMA; OROPHARYNGEAL CANCER; NECK CANCERS; GENDER-DIFFERENCES; ORAL-CAVITY; PROGNOSTIC-SIGNIFICANCE; PHARYNGEAL CANCER; HPV-DNA; HEAD; SURVIVAL AB Purpose: Human papillomavirus (HPV) is a major risk factor for specific cancers of the head and neck, particularly malignancies of the tonsil and base of the tongue. However, the role of HPV in the development of laryngeal cancer has not been definitively established. We conducted a population-based, cancer registry study to evaluate and characterize the genotype-specific prevalence of HPV in invasive laryngeal cancer cases diagnosed in the U.S. Methods: The presence of genotype-specific HPV DNA was evaluated using the Linear Array HPV Genotyping Test and the INNO-LiPA HPV Genotyping Assay in formalin-fixed paraffin embedded tissue from 148 invasive laryngeal cancer cases diagnosed in 1993-2004 within the catchment area of three U. S. SEER cancer registries. Results: HPV DNA was detected in 31 of 148 (21%) invasive laryngeal cancers. Thirteen different genotypes were detected. Overall, HPV 16 and HPV 33 were the most commonly detected types. HPV was detected in 33% (9/27) of women compared with 18% (22/121) of men (p=0.08). After adjustment for age and year of diagnosis, female patients were more likely to have HPV-positive laryngeal tumors compared to males (adjusted OR 2.84, 95% CI 1.07-7.51). Viral genotype differences were also observed between the sexes. While HPV 16 and 18 constituted half of HPV-positive cases occurring in men, among women, only 1 was HPV 16 positive and none were positive for HPV 18. Overall 5-year survival did not vary by HPV status. Conclusions: HPV may be involved in the development of a subset of laryngeal cancers and its role may be more predominant in women compared to men. C1 [Hernandez, Brenda Y.] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA. [Goodman, Marc T.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Lynch, Charles F.] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA USA. [Cozen, Wendy; Saber, Maria Sibug] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, USC Keck Sch Med, Los Angeles, CA 90033 USA. [Cozen, Wendy; Saber, Maria Sibug] Univ So Calif, Dept Prevent Med, USC Keck Sch Med, Los Angeles, CA 90089 USA. [Cozen, Wendy; Saber, Maria Sibug] Univ So Calif, Dept Pathol, USC Keck Sch Med, Los Angeles, CA 90089 USA. [Unger, Elizabeth R.; Steinau, Martin] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA. [Thompson, Trevor; Saraiya, Mona] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Altekruse, Sean F.] NCI, Div Canc Control & Populat Sci, Rockville, MD USA. [Lyu, Christopher] Battelle Mem Inst, Durham, NC USA. RP Hernandez, BY (reprint author), Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA. EM brenda@cc.hawaii.edu FU Centers for Disease Control and Prevention (CDC); SEER Program; National Institutes of Health, Department of Health and Human Services [N01-PC-35139, N01-PC-35143, N01-PC-35137]; CDC intramural funds; Vaccine for Children Funds; California Department of Health Services, California Health and Safety [103885]; NationalCancer Institute, National Institutes of Health, Department of Health and Human Services [N01-PC-2010-00035]; Centers for Disease Control and Prevention [1U58DP000807-3] FX This project was supported in part by the Centers for Disease Control and Prevention (CDC) and the SEER Program, National Institutes of Health, Department of Health and Human Services, under Contracts N01-PC-35139 (Los Angeles), N01-PC-35143 (Iowa) and N01-PC-35137 (Hawaii). The support for coordination of genotyping data and genotyping was largely supported by CDC intramural funds and Vaccine for Children Funds. The collection of data from California was largely supported by the California Department of Health Services as part of the statewide cancer reporting program mandated by California Health and Safety Code Section 103885; by the NationalCancer Institute, National Institutes of Health, Department of Health and Human Services under Contract N01-PC-2010-00035; and cooperative agreement number 1U58DP000807-3 from the Centers for Disease Control and Prevention. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 51 TC 7 Z9 7 U1 1 U2 9 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 29 PY 2014 VL 9 IS 12 AR e115931 DI 10.1371/journal.pone.0115931 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AX7UN UT WOS:000347120200083 PM 25546150 ER PT J AU Levin, ML Killmaster, LF Zemtsova, GE Ritter, JM Langham, G AF Levin, Michael L. Killmaster, Lindsay F. Zemtsova, Galina E. Ritter, Jana M. Langham, Gregory TI Clinical Presentation, Convalescence, and Relapse of Rocky Mountain Spotted Fever in Dogs Experimentally Infected via Tick Bite SO PLOS ONE LA English DT Article ID RHIPICEPHALUS-SANGUINEUS TICKS; RICKETTSIA-RICKETTSII; CHLORAMPHENICOL; PATHOGENESIS; DOXYCYCLINE; EFFICACY; IXODIDAE; ARIZONA; TYPHUS; BRAZIL AB Rocky Mountain spotted fever (RMSF) is a tick-borne disease caused by R. rickettsii in North and South America. Domestic dogs are susceptible to infection and canine RMSF can be fatal without appropriate treatment. Although clinical signs of R. rickettsii infection in dogs have been described, published reports usually include descriptions of either advanced clinical cases or experimental infections caused by needle-inoculation of cultured pathogen rather than by tick bite. The natural progression of a tick-borne R. rickettsii infection has not been studied in sufficient detail. Here, we provide a detailed description of clinical, hematological, molecular, and serological dynamics of RMSF in domestic dogs from the day of experimental exposure to infected ticks through recovery. Presented data indicate that neither the height/duration of fever nor detection of rickettsial DNA in dogs' blood by PCR are good indicators for clinical prognosis. Only the apex and subsequent subsidence of neutrophilia seem to mark the beginning of recovery and allow predicting a favorable outcome in Rickettsia-infected dogs, even despite the continuing persistence of mucosal petechiae and skin rash. On the other hand the appropriate (doxycycline) antibiotic therapy of sufficient duration is crucial in prevention of RMSF relapses in dogs. C1 [Levin, Michael L.; Killmaster, Lindsay F.; Zemtsova, Galina E.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. [Ritter, Jana M.] Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA USA. [Langham, Gregory] Ctr Dis Control & Prevent, Anim Resources Branch, Atlanta, GA USA. RP Levin, ML (reprint author), Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. EM MLevin@cdc.gov FU US Government within CDC budget FX Funding: Funding for work was provided by the US Government within the CDC budget. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 42 TC 5 Z9 5 U1 1 U2 14 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 26 PY 2014 VL 9 IS 12 AR e115105 DI 10.1371/journal.pone.0115105 PG 19 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AX9RO UT WOS:000347239900024 PM 25542001 ER PT J AU Roca-Feltrer, A Khim, N Kim, S Chy, S Canier, L Kerleguer, A Tor, P Chuor, CM Kheng, S Siv, S Kachur, PS Taylor, WRJ Hwang, J Menard, D AF Roca-Feltrer, Arantxa Khim, Nimol Kim, Saorin Chy, Sophy Canier, Lydie Kerleguer, Alexandra Tor, Pety Chuor, Char Meng Kheng, Sim Siv, Sovannaroth Kachur, Patrick S. Taylor, Walter R. J. Hwang, Jimee Menard, Didier TI Field Trial Evaluation of the Performances of Point-of-Care Tests for Screening G6PD Deficiency in Cambodia SO PLOS ONE LA English DT Article ID GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY; DEHYDROGENASE-DEFICIENCY; PLASMODIUM-FALCIPARUM; PRIMAQUINE THERAPY; X-CHROMOSOME; MALARIA; HEMOLYSIS; COMMON; 871G-GREATER-THAN-A; SENSITIVITY AB Background: User-friendly, accurate, point-of-care rapid tests to detect glucose-6-phosphate dehydrogenase deficiency (G6PDd) are urgently needed at peripheral level to safely recommend primaquine for malaria elimination. Methods: The CareStart G6PD RDT (AccessBio, New Jersey, USA), a novel rapid diagnostic test and the most commonly used test, the fluorescent spot test (FST) were assessed against the quantitatively measured G6PD enzyme activity for detecting G6PDd. Subjects were healthy males and non-pregnant females aged 18 years or older residing in six villages in Pailin Province, western Cambodia. Findings: Of the 938 subjects recruited, 74 (7.9%) were severe and moderately severe G6PD deficient (enzyme activity <30%), mostly in male population; population median G6PD activity was 12.0 UI/g Hb. The performances of the CareStart G6PD RDT and the FST, according to different cut-off values used to define G6PDd were very similar. For the detection of severe and moderately severe G6PDd (enzyme activity <30%, <3.6 UI/g Hb) in males and females, sensitivity and negative (normal status) predictive value were 100% for both point-of-care tools. When the G6PDd cut-off value increased (from <40% to <60%), the sensitivity for both PoCs decreased: 93.3% to 71.7% (CareStart G6PD RDT, p=10(-6)) and 95.5% to 73.2% (FST, p=10(-6)) while the specificity for both PoCs remained similar: 97.4% to 98.3% (CareStart G6PD RDT, p=0.23) and 98.7% to 99.6% (FST, p=0.06). The cut-off values for classifying individuals as normal were 4.0 UI/g Hb and 4.3 UI/g Hb for the CareStart G6PD RDTand the FST, respectively. Conclusions: The CareStart G6PD RDT reliably detected moderate and severe G6PD deficient individuals (enzyme activity <30%), suggesting that this novel point-of-care is a promising tool for tailoring appropriate primaquine treatment for malaria elimination by excluding individuals with severe G6PDd for primaquine treatment. C1 [Roca-Feltrer, Arantxa] Malaria Consortium, Phnom Penh, Cambodia. [Khim, Nimol; Kim, Saorin; Chy, Sophy; Canier, Lydie; Menard, Didier] Inst Pasteur Cambodia, Malaria Mol Epidemiol Unit, Phnom Penh, Cambodia. [Kerleguer, Alexandra; Tor, Pety] Inst Pasteur Cambodia, Med Lab, Phnom Penh, Cambodia. [Chuor, Char Meng; Kheng, Sim; Siv, Sovannaroth; Taylor, Walter R. J.] Entomol & Malaria Control CNM, Natl Ctr Parasitol, Phnom Penh, Cambodia. [Kachur, Patrick S.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Taylor, Walter R. J.] Hop Univ Geneve, Ctr Med Humanitaire, Geneva, Switzerland. [Hwang, Jimee] Univ Calif San Francisco, Global Hlth Grp, San Francisco, CA 94143 USA. RP Menard, D (reprint author), Inst Pasteur Cambodia, Malaria Mol Epidemiol Unit, Phnom Penh, Cambodia. EM dmenard@pasteur-kh.org FU Presidents Malaria Initiative via the Office of Health, Infectious Diseases, and Nutrition; Bureau for Global Health, U.S. Agency for International Development; French Ministry of Foreign Affairs FX This research was made possible through support provided by the Presidents Malaria Initiative via the Office of Health, Infectious Diseases, and Nutrition, Bureau for Global Health, U.S. Agency for International Development, under the terms of an Inter-agency Agreement with CDC and by the Institut Pasteur in Cambodia. DM was supported by the French Ministry of Foreign Affairs. WRJT was supported by the 5% initiative of the French Government from October 2013 for one year as a consultant in operational research to the National Center for Parasitology, Entomology and Malaria Control (CNM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 33 TC 12 Z9 12 U1 1 U2 20 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 26 PY 2014 VL 9 IS 12 AR e116143 DI 10.1371/journal.pone.0116143 PG 16 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AX9RO UT WOS:000347239900148 PM 25541721 ER PT J AU Lolekha, R Kullerk, N Wolfe, MI Klumthanom, K Singhagowin, T Pattanasin, S Sombat, P Naiwatanakul, T Leartvanangkul, C Voramongkol, N AF Lolekha, Rangsima Kullerk, Nareeluck Wolfe, Mitchell I. Klumthanom, Kanyarat Singhagowin, Thapanaporn Pattanasin, Sarika Sombat, Potjaman Naiwatanakul, Thananda Leartvanangkul, Chailai Voramongkol, Nipunporn TI Assessment of a couples HIV counseling and testing program for pregnant women and their partners in antenatal care (ANC) in 7 provinces, Thailand SO BMC INTERNATIONAL HEALTH AND HUMAN RIGHTS LA English DT Article DE Couples counseling; Pregnant women; ANC; Thailand ID TO-CHILD TRANSMISSION; PREVENTION; INTERVENTIONS; INFECTION; TANZANIA; EFFICACY; COHORT; PMTCT; RISK AB Background: Couples HIV testing and counseling (CHTC) at antenatal care (ANC) settings allows pregnant women to learn the HIV status of themselves and their partners. Couples can make decisions together to prevent HIV transmission. In Thailand, men were tested at ANC settings only if their pregnant partners were HIV positive. A CHTC program based in ANC settings was developed and implemented at 16 pilot hospitals in 7 provinces during 2009-2010. Methods: Cross-sectional data were collected using standard data collection forms from all pregnant women and accompanying partners who presented at first ANC visit at 16 hospitals. CHTC data for women and partners were analyzed to determine service uptake and HIV test results among couples. In-depth interviews were conducted among hospital staff of participating hospitals during field supervision visits to assess feasibility and acceptability of CHTC services. Results: During October 2009-April 2010, 4,524 women initiating ANC were enrolled. Of these, 2,435 (54%) women came for ANC alone; 2,089 (46%) came with partners. Among men presenting with partners, 2,003 (96%) received couples counseling. Of these, 1,723 (86%) men and all pregnant women accepted HIV testing. Among 1,723 couples testing for HIV, 1,604 (93%) returned for test results. Of these, 1,567 (98%) were concordant negative, 6 (0.4%) were concordant positive and 17 (1%) were HIV discordant (7 male+/female- and 10 male-/female+). Nine of ten (90%) executive hospital staff reported high acceptability of CHTC services. Conclusions: CHTC implemented in ANC settings helps identify more HIV-positive men whose partners were negative than previous practice, with high acceptability among hospital staff. C1 [Lolekha, Rangsima; Wolfe, Mitchell I.; Klumthanom, Kanyarat; Pattanasin, Sarika; Sombat, Potjaman; Naiwatanakul, Thananda] Thailand MOPH US CDC Collaborat TUC, Global AIDS Program, Nonthaburi 11000, Thailand. [Kullerk, Nareeluck; Singhagowin, Thapanaporn; Leartvanangkul, Chailai; Voramongkol, Nipunporn] Minist Publ Hlth, DOH, Nonthaburi, Thailand. [Wolfe, Mitchell I.] US Ctr Dis Control & Prevent, Atlanta, GA USA. RP Lolekha, R (reprint author), Thailand MOPH US CDC Collaborat TUC, Global AIDS Program, Mail POB 139, Nonthaburi 11000, Thailand. EM hpu8@cdc.gov FU U.S. President's Emergency Plan for AIDS Relief (PEPFAR) through the U.S. CDC [5U19GH000004-04] FX The authors acknowledge the staff of the ANC clinics of the 15 hospitals for their contribution and support of this project. We thank the pregnant women and partners who participated in this project. This research has been supported by the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) through the U.S. CDC under the terms of 5U19GH000004-04. NR 30 TC 2 Z9 2 U1 2 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-698X J9 BMC INT HEALTH HUM R JI BMC Int. Health Hum. Rights. PD DEC 24 PY 2014 VL 14 AR 39 DI 10.1186/s12914-014-0039-2 PG 10 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA CA7WC UT WOS:000349127100001 PM 25539670 ER PT J AU Njuguna, HN Caselton, DL Arunga, GO Emukule, GO Kinyanjui, DK Kalani, RM Kinkade, C Muthoka, PM Katz, MA Mott, JA AF Njuguna, Henry N. Caselton, Deborah L. Arunga, Geoffrey O. Emukule, Gideon O. Kinyanjui, Dennis K. Kalani, Rosalia M. Kinkade, Carl Muthoka, Phillip M. Katz, Mark A. Mott, Joshua A. TI A comparison of smartphones to paper-based questionnaires for routine influenza sentinel surveillance, Kenya, 2011-2012 SO BMC MEDICAL INFORMATICS AND DECISION MAKING LA English DT Article DE Data collection; Electronic; Pen-and-paper; Smartphone; Quality; Cost; Timeliness ID ELECTRONIC DATA-ENTRY; HAND-HELD COMPUTERS; DATA-COLLECTION; CLINICAL-TRIALS; ZANZIBAR; SYSTEMS; FORMS AB Background: For disease surveillance, manual data collection using paper-based questionnaires can be time consuming and prone to errors. We introduced smartphone data collection to replace paper-based data collection for an influenza sentinel surveillance system in four hospitals in Kenya. We compared the quality, cost and timeliness of data collection between the smartphone data collection system and the paper-based system. Methods: Since 2006, the Kenya Ministry of Health (MoH) with technical support from the Kenya Medical Research Institute/Centers for Disease Control and Prevention (KEMRI/CDC) conducted hospital-based sentinel surveillance for influenza in Kenya. In May 2011, the MOH replaced paper-based collection with an electronic data collection system using Field Adapted Survey Toolkit (FAST) on HTC Touch Pro2 smartphones at four sentinel sites. We compared 880 paper-based questionnaires dated Jan 2010-Jun 2011 and 880 smartphone questionnaires dated May 2011-Jun 2012 from the four surveillance sites. For each site, we compared the quality, cost and timeliness of each data collection system. Results: Incomplete records were more likely seen in data collected using pen-and-paper compared to data collected using smartphones (adjusted incidence rate ratio (aIRR) 7, 95% CI: 4.4-10.3). Errors and inconsistent answers were also more likely to be seen in data collected using pen-and-paper compared to data collected using smartphones (aIRR: 25, 95% CI: 12.5-51.8). Smartphone data was uploaded into the database in a median time of 7 days while paper-based data took a median of 21 days to be entered (p < 0.01). It cost USD 1,501 (9.4%) more to establish the smartphone data collection system ($17,500) than the pen-and-paper system (USD $15,999). During two years, however, the smartphone data collection system was $3,801 (7%) less expensive to operate ($50,200) when compared to pen-and-paper system ($54,001). Conclusions: Compared to paper-based data collection, an electronic data collection system produced fewer incomplete data, fewer errors and inconsistent responses and delivered data faster. Although start-up costs were higher, the overall costs of establishing and running the electronic data collection system were lower compared to paper-based data collection system. Electronic data collection using smartphones has potential to improve timeliness, data integrity and reduce costs. C1 [Njuguna, Henry N.; Caselton, Deborah L.; Emukule, Gideon O.; Katz, Mark A.; Mott, Joshua A.] Ctr Dis Control & Prevent Kenya, Influenza Program, Nairobi 00621, Kenya. [Arunga, Geoffrey O.; Kinyanjui, Dennis K.] Kenya Med Res Inst KEMRI, Nairobi, Kenya. [Kalani, Rosalia M.; Muthoka, Phillip M.] Minist Hlth, DDSR, Nairobi, Kenya. [Kinkade, Carl] Ctr Dis Control, Ctr Surveillance Epidemiol, Atlanta, GA USA. [Kinkade, Carl] Ctr Dis Control, Lab Serv, Atlanta, GA USA. RP Njuguna, HN (reprint author), Ctr Dis Control & Prevent Kenya, Influenza Program, POB 606,Village Market, Nairobi 00621, Kenya. EM vkc7@cdc.gov NR 15 TC 1 Z9 1 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1472-6947 J9 BMC MED INFORM DECIS JI BMC Med. Inform. Decis. Mak. PD DEC 24 PY 2014 VL 14 AR 107 DI 10.1186/s12911-014-0107-5 PG 9 WC Medical Informatics SC Medical Informatics GA AZ9RH UT WOS:000348551200001 PM 25539745 ER PT J AU West, KP Shamim, AA Mehra, S Labrique, AB Ali, H Shaikh, S Klemm, RDW Wu, LSF Mitra, M Haque, R Hanif, AAM Massie, AB Merrill, RD Schulze, KJ Christian, P AF West, Keith P., Jr. Shamim, Abu Ahmed Mehra, Sucheta Labrique, Alain B. Ali, Hasmot Shaikh, Saijuddin Klemm, Rolf D. W. Wu, Lee S-F. Mitra, Maithilee Haque, Rezwanul Hanif, Abu A. M. Massie, Allan B. Merrill, Rebecca Day Schulze, Kerry J. Christian, Parul TI Effect of Maternal Multiple Micronutrient vs Iron-Folic Acid Supplementation on Infant Mortality and Adverse Birth Outcomes in Rural Bangladesh The JiVitA-3 Randomized Trial SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID BETA-CAROTENE SUPPLEMENTATION; MIDDLE-INCOME COUNTRIES; FOR-GESTATIONAL-AGE; DOUBLE-BLIND; VITAMIN-A; SYSTEMATIC ANALYSIS; COMMUNITY TRIAL; PREGNANT-WOMEN; PRETERM BIRTH; FETAL LOSS AB IMPORTANCE Maternal micronutrient deficiencies may adversely affect fetal and infant health, yet there is insufficient evidence of effects on these outcomes to guide antenatal micronutrient supplementation in South Asia. OBJECTIVE To assess effects of antenatal multiple micronutrient vs iron-folic acid supplementation on 6-month infant mortality and adverse birth outcomes. DESIGN, SETTING, AND PARTICIPANTS Cluster randomized, double-masked trial in Bangladesh, with pregnancy surveillance starting December 4, 2007, and recruitment on January 11, 2008. Six-month infant follow-up ended August 30, 2012. Surveillance included 127 282 women; 44 567 became pregnant and were included in the analysis and delivered 28 516 live-born infants. Median gestation at enrollment was 9 weeks (interquartile range, 7-12). INTERVENTIONS Women were provided supplements containing 15 micronutrients or iron-folic acid alone, taken daily from early pregnancy to 12 weeks postpartum. MAIN OUTCOMES AND MEASURES The primary outcome was all-cause infant mortality through 6 months (180 days). Prespecified secondary outcomes in this analysis included stillbirth, preterm birth (<37 weeks), and low birth weight (<2500 g). To maintain overall significance of a=.05, a Bonferroni-corrected a=.01 was calculated to evaluate statistical significance of primary and 4 secondary risk outcomes (.05/5). RESULTS Among the 22 405 pregnancies in the multiple micronutrient group and the 22 162 pregnancies in the iron-folic acid group, there were 14 374 and 14 142 live-born infants, respectively, included in the analysis. At 6 months, multiple micronutrients did not significantly reduce infant mortality; there were 764 deaths (54.0 per 1000 live births) in the iron-folic acid group and 741 deaths (51.6 per 1000 live births) in the multiple micronutrient group (relative risk [RR], 0.95; 95% CI, 0.86-1.06). Multiple micronutrient supplementation resulted in a non-statistically significant reduction in stillbirths (43.1 vs 48.2 per 1000 births; RR, 0.89; 95% CI, 0.81-0.99; P=.02) and significant reductions in preterm births (18.6 vs 21.8 per 100 live births; RR, 0.85; 95% CI, 0.80-0.91; P<.001) and low birth weight (40.2 vs 45.7 per 100 live births; RR, 0.88; 95% CI, 0.85-0.91; P<.001). CONCLUSIONS AND RELEVANCE In Bangladesh, antenatal multiple micronutrient compared with iron-folic acid supplementation did not reduce all-cause infant mortality to age 6 months but resulted in a non-statistically significant reduction in stillbirths and significant reductions in preterm births and low birth weight. C1 [West, Keith P., Jr.; Shamim, Abu Ahmed; Mehra, Sucheta; Labrique, Alain B.; Ali, Hasmot; Shaikh, Saijuddin; Klemm, Rolf D. W.; Wu, Lee S-F.; Mitra, Maithilee; Massie, Allan B.; Schulze, Kerry J.; Christian, Parul] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Human Nutr, Dept Int Hlth, Baltimore, MD 21205 USA. [Shamim, Abu Ahmed; Ali, Hasmot; Shaikh, Saijuddin; Haque, Rezwanul; Hanif, Abu A. M.] JiVitA Project, Gaibandha, Bangladesh. [Massie, Allan B.] Johns Hopkins Sch Med, Dept Surg, Baltimore, MD USA. [Merrill, Rebecca Day] Ctr Dis Control & Prevent, Atlanta, GA USA. RP West, KP (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, W2041,615 N Wolfe St, Baltimore, MD 21205 USA. EM kwest1@jhu.edu FU Global Control of Micronutrient Deficiency from Bill and Melinda Gates Foundation [OPP614] FX The JiVitA-3 Trial was funded through grant OPP614 (Global Control of Micronutrient Deficiency) from the Bill and Melinda Gates Foundation (Ellen Piwoz, ScD, Senior Program Officer). Additional assistance was received from the Sight and Life Global Nutrition Research Institute. DSM formulated, prepared, and delivered in-country micronutrient premixes for supplement production gratis and tested supplement potency throughout the trial gratis. Beximco Pharmaceuticals produced, bottled, labeled, and delivered to the field site 16 million study tablets during the trial gratis and delivered an additional 1 million multiple micronutrient supplements gratis to support posttrial antenatal supplement delivery services in the community. NR 45 TC 22 Z9 22 U1 4 U2 27 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 24 PY 2014 VL 312 IS 24 BP 2649 EP 2658 DI 10.1001/jama.2014.16819 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA AX5KW UT WOS:000346966100017 PM 25536256 ER PT J AU DeBess, E Lockhart, SR Iqbal, N Cieslak, PR AF DeBess, Emilio Lockhart, Shawn R. Iqbal, Naureen Cieslak, Paul R. TI Isolation of Cryptococcus gattii from Oregon soil and tree bark, 2010-2011 SO BMC MICROBIOLOGY LA English DT Article ID NEOFORMANS VAR GATTII; PAPUA-NEW-GUINEA; BRITISH-COLUMBIA; MENINGITIS; CANADA; EPIDEMIOLOGY; VARIETY; HOST AB Background: In Oregon, human and animal infections by C. gattii were first identified in 2004. Cryptococcus gattii is considered to be an emerging non- zoonotic infection affecting animals and humans in Oregon. We report a longitudinal environmental isolation of C. gattii after an Oregon dog was diagnosed with the disease in 2009. Results: Cryptococcus gattii was isolated twice from the same location with a span of one year between isolation dates. Cryptococcus gattii molecular types VGIIa and VGI were isolated in 2010 from soil and tree bark near the home of a 9- month-old dog which three months previously had an infection caused by C. gattii genotype VGIIa. The environment featured heavy growth of Douglas Fir trees. In 2011, a second set of soil and tree bark samples was collected in the same area and C. gattii VGIIa was again identified from the environment, along with genotypes VGIIb and VGIIc. Conclusions: The use of animal surveillance data to identify environmental niches of C. gattii should be considered to expand the understanding of this emerging pathogen. Understanding the ecology and how the environment and other factors might modify the existing niches is important for assessing risk and for designing measures to protect human and animal health. C1 [DeBess, Emilio; Cieslak, Paul R.] Publ Hlth Div, Oregon Hlth Author, Portland, OR 97232 USA. [Lockhart, Shawn R.; Iqbal, Naureen] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30330 USA. RP DeBess, E (reprint author), Publ Hlth Div, Oregon Hlth Author, 800 NE Oregon St 772, Portland, OR 97232 USA. EM emilio.e.debess@state.or.us FU NCPDCID CDC HHS [3U01CI000306] NR 21 TC 1 Z9 1 U1 2 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2180 J9 BMC MICROBIOL JI BMC Microbiol. PD DEC 21 PY 2014 VL 14 AR 323 DI 10.1186/s12866-014-0323-2 PG 4 WC Microbiology SC Microbiology GA AZ4HQ UT WOS:000348182700001 PM 25528464 ER PT J AU Henderson, KC Sheppard, ES Rivera-Betancourt, OE Choi, JY Dluhy, RA Thurman, KA Winchell, JM Krause, DC AF Henderson, Kelley C. Sheppard, Edward S. Rivera-Betancourt, Omar E. Choi, Joo-Young Dluhy, Richard A. Thurman, Kathleen A. Winchell, Jonas M. Krause, Duncan C. TI The multivariate detection limit for Mycoplasma pneumoniae as determined by nanorod array-surface enhanced Raman spectroscopy and comparison with limit of detection by qPCR SO ANALYST LA English DT Article ID PREPARED SILVER SURFACE; SENSITIVE DETECTION; CLINICAL SPECIMENS; BACTERIAL-CELLS; SCATTERING; IDENTIFICATION; SERS; SUBSTRATE; PROTEINS; DISCRIMINATION AB Mycoplasma pneumoniae is a cell wall-less bacterial pathogen of the human respiratory tract that accounts for up to 20% of community-acquired pneumonia. At present, the standard for detection and genotyping is quantitative polymerase chain reaction (qPCR), which can exhibit excellent sensitivity but lacks standardization and has limited practicality for widespread, point-of-care use. We previously described a Ag nanorod array-surface enhanced Raman spectroscopy (NA-SERS) biosensing platform capable of detecting M. pneumoniae in simulated and true clinical throat swab samples with statistically significant specificity and sensitivity. We report here that differences in sample preparation influence the integrity of mycoplasma cells for NA-SERS analysis, which in turn impacts the resulting spectra. We have established a multivariate detection limit (MDL) using NA-SERS for M. pneumoniae intact-cell sample preparations. Using an adaptation of International Union of Pure and Applied Chemistry (IUPAC)-recommended methods for analyzing multivariate data sets, we found that qPCR had roughly 10 x better detection limits than NA-SERS when expressed in CFU ml(-1) and DNA concentration (fg). However, the NA-SERS MDL for intact M. pneumoniae was 5.3 +/- 1.0 genome equivalents (cells per mu l). By comparison, qPCR of a parallel set of samples yielded a limit of detection of 2.5 +/- 0.25 cells per mu l. Therefore, for certain standard metrics NA-SERS provides a multivariate detection limit for M. pneumoniae that is essentially identical to that determined via qPCR. C1 [Henderson, Kelley C.; Sheppard, Edward S.; Krause, Duncan C.] Univ Georgia, Dept Microbiol, Athens, GA 30602 USA. [Rivera-Betancourt, Omar E.; Choi, Joo-Young; Dluhy, Richard A.] Univ Georgia, Dept Chem, Athens, GA 30602 USA. [Thurman, Kathleen A.; Winchell, Jonas M.] Ctr Dis Control & Prevent, Pneumonia Response & Surveillance Lab, Atlanta, GA USA. RP Krause, DC (reprint author), Univ Georgia, Dept Microbiol, Athens, GA 30602 USA. EM dkrause@uga.edu FU Public Health Service from the US National Institutes of Health [AI096364, GM102546] FX This work was supported by Public Health Service research grants AI096364 (DCK) and GM102546 (RAD) from the US National Institutes of Health. NR 60 TC 7 Z9 7 U1 1 U2 45 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 0003-2654 EI 1364-5528 J9 ANALYST JI Analyst PD DEC 21 PY 2014 VL 139 IS 24 BP 6426 EP 6434 DI 10.1039/c4an01141d PG 9 WC Chemistry, Analytical SC Chemistry GA AT9SB UT WOS:000345265300015 PM 25335653 ER PT J AU Sionean, C Le, BC Hageman, K Oster, AM Wejnert, C Hess, KL Paz-Bailey, G AF Sionean, Catlainn Le, Binh C. Hageman, Kathy Oster, Alexandra M. Wejnert, Cyprian Hess, Kristen L. Paz-Bailey, Gabriela CA NHBS Study Grp TI HIV Risk, Prevention, and Testing Behaviors Among Heterosexuals at Increased Risk for HIV Infection - National HIV Behavioral Surveillance System, 21 US Cities, 2010 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID SEXUALLY-TRANSMITTED INFECTIONS; FORCE RECOMMENDATION STATEMENT; UNITED-STATES; ALCOHOL-USE; TREATMENT OUTCOMES; AFRICAN-AMERICANS; ANAL INTERCOURSE; VIRAL-HEPATITIS; BINGE DRINKING; GENITAL-TRACT AB Problem/Condition: At the end of 2010, an estimated 872,990 persons in the United States were living with a diagnosis of human immunodeficiency virus (HIV) infection. Approximately one in four of the estimated HIV infections diagnosed in 2011 were attributed to heterosexual contact. Heterosexuals with a low socioeconomic status (SES) are disproportionately likely to be infected with HIV. Reporting Period: June December 2010. Description of System: The National HIV Behavioral Surveillance System (NHBS) collects HIV prevalence and risk behavior data in selected metropolitan statistical areas (MSAs) from three populations at high risk for HIV infection: men who have sex with men, injecting drug users, and heterosexuals at increased risk for HIV infection. Data for NHBS are collected in rotating cycles in these three different populations. For the 2010 NHBS cycle among heterosexuals, men and women were eligible to participate if they were aged 18-60 years, lived in a participating MSA, were able to complete a behavioral survey in English or Spanish, and reported engaging in vaginal or anal sex with one or more opposite-sex partners in the 12 months before the interview. Persons who consented to participate completed an interviewer-administered, standardized questionnaire about HIV-associated behaviors and were offered anonymous HIV testing. Participants were sampled using respondent-driven sampling, a type of chain-referral sampling. Sampling focused on persons of low SES (i.e., income at the poverty level or no more than a high school education) because results of a pilot study indicated that heterosexual adults of low SES were more likely than those of high SES to be infected with HIV. To assess risk and testing experiences among persons at risk for acquiring HIV infection through heterosexual sex, analyses excluded participants who were not low SES, those who reported ever having tested positive for HIV, and those who reported recent (i.e., in the 12 months before the interview) male-male sex or injection drug use. This report summarizes unweighted data regarding HIV-associated risk, prevention, and testing behaviors from 9,278 heterosexual men and women interviewed in 2010 (the second cycle of NHBS data collection among heterosexuals). Results: The median age of participants was 35 years; 47% were men. The majority of participants were black or African American (hereafter referred to as black) (72%) or Hispanic/Latino (21%). Most participants (men: 88%; women: 90%) reported having vaginal sex without a condom with one or more opposite-sex partners in the past 12 months; approximately one third (men: 30%; women: 29%) reported anal sex without a condom with one or more opposite-sex partners. The majority of participants (59%) reported using noninjection drugs in the 12 months before the interview; nearly one in seven (15%) had used crack cocaine. Although most participants (men: 71%; women: 77%) had ever been tested for HIV, this percentage was lower among Hispanic/Latino participants (men: 52%; women: 62%). Approximately one third (34%) of participants reported receiving free condoms in the 12 months before the interview; 11% reported participating in a behavioral HIV prevention program. Interpretation: A substantial proportion of heterosexuals interviewed for the 2010 NHBS heterosexual cycle reported engaging in behaviors that increase the risk for HIV infection. However, HIV testing was suboptimal among the overall sample, including among groups disproportionately affected by HIV infection (i.e., blacks and Hispanics/Latinos). Public Health Action: Increasing coverage of HIV testing and other HIV prevention services among heterosexuals at increased risk is important, especially among groups disproportionately affected by HIV infection, such as blacks and Hispanics/Latinos. The National HIV/AIDS Strategy for the United States delineates a coordinated national response to reduce infections and HIV-related health disparities among disproportionately affected groups. NHBS data can guide national and local planning efforts to maximize the impact of HIV prevention programs. C1 [Sionean, Catlainn; Le, Binh C.; Hageman, Kathy; Oster, Alexandra M.; Wejnert, Cyprian; Hess, Kristen L.; Paz-Bailey, Gabriela] Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div HIV AIDS Prevent, Atlanta, GA USA. [Hess, Kristen L.] ORISE Res Participat Program, Oak Ridge, TN USA. RP Sionean, C (reprint author), CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM csionean@cdc.gov NR 67 TC 0 Z9 0 U1 2 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 19 PY 2014 VL 63 IS 14 SU S BP 1 EP 39 PG 39 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY7MU UT WOS:000347745000001 ER PT J AU Sionean, C Le, BC Hageman, K Oster, AM Wejnert, C Hess, KL Paz-Bailey, G AF Sionean, Catlainn Le, Binh C. Hageman, Kathy Oster, Alexandra M. Wejnert, Cyprian Hess, Kristen L. Paz-Bailey, Gabriela CA NHBS Study Grp TI HIV Risk, Prevention, and Testing Behaviors Among Heterosexuals at Increased Risk for HIV Infection - National HIV Behavioral Surveillance System, 21 US Cities, 2010 SO MMWR SURVEILLANCE SUMMARIES LA English DT Article ID SEXUALLY-TRANSMITTED INFECTIONS; FORCE RECOMMENDATION STATEMENT; UNITED-STATES; ALCOHOL-USE; TREATMENT OUTCOMES; AFRICAN-AMERICANS; ANAL INTERCOURSE; VIRAL-HEPATITIS; BINGE DRINKING; GENITAL-TRACT AB Problem/Condition: At the end of 2010, an estimated 872,990 persons in the United States were living with a diagnosis of human immunodeficiency virus (HIV) infection. Approximately one in four of the estimated HIV infections diagnosed in 2011 were attributed to heterosexual contact. Heterosexuals with a low socioeconomic status (SES) are disproportionately likely to be infected with HIV. Reporting Period: June-December 2010. Description of System: The National HIV Behavioral Surveillance System (NHBS) collects HIV prevalence and risk behavior data in selected metropolitan statistical areas (MSAs) from three populations at high risk for HIV infection: men who have sex with men, injecting drug users, and heterosexuals at increased risk for HIV infection. Data for NHBS are collected in rotating cycles in these three different populations. For the 2010 NHBS cycle among heterosexuals, men and women were eligible to participate if they were aged 18-60 years, lived in a participating MSA, were able to complete a behavioral survey in English or Spanish, and reported engaging in vaginal or anal sex with one or more opposite-sex partners in the 12 months before the interview. Persons who consented to participate completed an interviewer-administered, standardized questionnaire about HIV-associated behaviors and were offered anonymous HIV testing. Participants were sampled using respondent-driven sampling, a type of chain-referral sampling. Sampling focused on persons of low SES (i.e., income at the poverty level or no more than a high school education) because results of a pilot study indicated that heterosexual adults of low SES were more likely than those of high SES to be infected with HIV. To assess risk and testing experiences among persons at risk for acquiring HIV infection through heterosexual sex, analyses excluded participants who were not low SES, those who reported ever having tested positive for HIV, and those who reported recent (i.e., in the 12 months before the interview) male-male sex or injection drug use. This report summarizes unweighted data regarding HIV-associated risk, prevention, and testing behaviors from 9,278 heterosexual men and women interviewed in 2010 (the second cycle of NHBS data collection among heterosexuals). Results: The median age of participants was 35 years; 47% were men. The majority of participants were black or African American (hereafter referred to as black) (72%) or Hispanic/Latino (21%). Most participants (men: 88%; women: 90%) reported having vaginal sex without a condom with one or more opposite-sex partners in the past 12 months; approximately one third (men: 30%; women: 29%) reported anal sex without a condom with one or more opposite-sex partners. The majority of participants (59%) reported using noninjection drugs in the 12 months before the interview; nearly one in seven (15%) had used crack cocaine. Although most participants (men: 71%; women: 77%) had ever been tested for HIV, this percentage was lower among Hispanic/Latino participants (men: 52%; women: 62%). Approximately one third (34%) of participants reported receiving free condoms in the 12 months before the interview; 11% reported participating in a behavioral HIV prevention program. Interpretation: A substantial proportion of heterosexuals interviewed for the 2010 NHBS heterosexual cycle reported engaging in behaviors that increase the risk for HIV infection. However, HIV testing was suboptimal among the overall sample, including among groups disproportionately affected by HIV infection (i.e., blacks and Hispanics/Latinos). Public Health Action: Increasing coverage of HIV testing and other HIV prevention services among heterosexuals at increased risk is important, especially among groups disproportionately affected by HIV infection, such as blacks and Hispanics/Latinos. The National HIV/AIDS Strategy for the United States delineates a coordinated national response to reduce infections and HIV-related health disparities among disproportionately affected groups. NHBS data can guide national and local planning efforts to maximize the impact of HIV prevention programs. RP Sionean, C (reprint author), CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. EM csionean@cdc.gov NR 67 TC 5 Z9 5 U1 0 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-8636 J9 MMWR SURVEILL SUMM JI MMWR Surv. Summ. PD DEC 19 PY 2014 VL 63 IS 14 BP 1 EP 42 PG 42 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY5SG UT WOS:000347631300001 ER PT J AU Rolfes, M Blanton, L Brammer, L Smith, S Mustaquim, D Steffens, C Cohen, J Leon, M Chaves, SS Abd Elal, AI Gubareva, L Hall, H Wallis, T Villanueva, J Xu, XY Bresee, J Cox, N Finelli, L AF Rolfes, Melissa Blanton, Lenee Brammer, Lynnette Smith, Sophie Mustaquim, Desiree Steffens, Craig Cohen, Jessica Leon, Michelle Chaves, Sandra S. Abd Elal, Anwar Isa Gubareva, Larisa Hall, Henrietta Wallis, Teresa Villanueva, Julie Xu, Xiyan Bresee, Joseph Cox, Nancy Finelli, Lyn TI Update: Influenza Activity - United States, September 28-December 6, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article RP Rolfes, M (reprint author), CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM mrolfes1@cdc.gov NR 4 TC 12 Z9 13 U1 0 U2 2 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 19 PY 2014 VL 63 IS 50 BP 1189 EP 1194 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX5DH UT WOS:000346946700002 PM 25522086 ER PT J AU Ridpath, A Driver, CR Nolan, ML Karpati, A Kass, D Paone, D Jakubowski, A Hoffman, RS Nelson, LS Kunin, HV AF Ridpath, Alison Driver, Cynthia R. Nolan, Michelle L. Karpati, Adam Kass, Daniel Paone, Denise Jakubowski, Andrea Hoffman, Robert S. Nelson, Lewis S. Kunin, Hillary V. TI Illnesses and Deaths Among Persons Attending an Electronic Dance-Music Festival - New York City, 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID ECSTASY; 3,4-METHYLENEDIOXYMETHAMPHETAMINE C1 [Ridpath, Alison; Driver, Cynthia R.; Nolan, Michelle L.; Karpati, Adam; Kass, Daniel; Paone, Denise; Jakubowski, Andrea; Hoffman, Robert S.; Nelson, Lewis S.; Kunin, Hillary V.] CDC, New York City Dept Hlth & Mental Hyg, Atlanta, GA 30333 USA. [Ridpath, Alison] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. RP Kunin, HV (reprint author), CDC, New York City Dept Hlth & Mental Hyg, Atlanta, GA 30333 USA. EM hkunins1@health.nyc.gov NR 8 TC 13 Z9 13 U1 0 U2 13 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 19 PY 2014 VL 63 IS 50 BP 1195 EP 1198 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX5DH UT WOS:000346946700003 PM 25522087 ER PT J AU Summers, A Nyenswah, TG Montgomery, JM Neatherlin, J Tappero, JW AF Summers, Aimee Nyenswah, Tolbert G. Montgomery, Joel M. Neatherlin, John Tappero, Jordan W. TI Challenges in Responding to the Ebola Epidemic - Four Rural Counties, Liberia, August-November 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Summers, Aimee] CDC, Epidem Intelligence Serv, Ctr Global Hlth, Atlanta, GA 30333 USA. [Summers, Aimee; Montgomery, Joel M.; Neatherlin, John; Tappero, Jordan W.] CDC, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA 30333 USA. [Nyenswah, Tolbert G.] CDC, Liberian Minist Hlth & Social Welf, Ctr Global Hlth, Atlanta, GA 30333 USA. [Montgomery, Joel M.; Neatherlin, John] CDC, CDC Kenya, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Summers, A (reprint author), CDC, Epidem Intelligence Serv, Ctr Global Hlth, Atlanta, GA 30333 USA. EM asummers1@cdc.gov; tgnyenswah74@yahoo.com NR 8 TC 9 Z9 9 U1 0 U2 20 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 19 PY 2014 VL 63 IS 50 BP 1202 EP 1204 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX5DH UT WOS:000346946700005 PM 25522089 ER PT J AU Lee-Kwan, SH DeLuca, N Adams, M Dalling, M Drevlow, E Gassama, G Davies, T AF Lee-Kwan, Seung Hee DeLuca, Nickolas Adams, Monica Dalling, Matthew Drevlow, Elizabeth Gassama, Gladys Davies, Tina TI Support Services for Survivors of Ebola Virus Disease - Sierra Leone, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Lee-Kwan, Seung Hee; Adams, Monica] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Lee-Kwan, Seung Hee] CDC, Div Nutr Phys Act & Obes, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA. [DeLuca, Nickolas] CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Dalling, Matthew] UNICEF, Bonthe, Sierra Leone. [Drevlow, Elizabeth] GOAL, Makeni, Sierra Leone. [Gassama, Gladys] Kenerna Govt Hosp, Kenema, Sierra Leone. [Davies, Tina] Sierra Leone Minist Social Welf Gender & Children, Makeni, Sierra Leone. RP Lee-Kwan, SH (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM sleekwan@cdc.gov NR 8 TC 8 Z9 8 U1 0 U2 11 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 19 PY 2014 VL 63 IS 50 BP 1205 EP 1206 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX5DH UT WOS:000346946700006 PM 25522090 ER PT J AU Arwady, MA Garcia, EL Wollor, B Mabande, LG Reaves, EJ Montgomery, JM AF Arwady, M. Allison Garcia, Edmundo L. Wollor, Benedict Mabande, Lyndon G. Reaves, Erik J. Montgomery, Joel M. TI Reintegration of Ebola Survivors into Their Communities - Firestone District, Liberia, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID VIRUS DISEASE; EPIDEMIC C1 [Arwady, M. Allison; Reaves, Erik J.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Garcia, Edmundo L.; Wollor, Benedict; Mabande, Lyndon G.] Firestone Liberia Inc, Nashville, TN USA. [Montgomery, Joel M.] CDC, Div Global Hlth Protect Kenya, Atlanta, GA 30333 USA. RP Arwady, MA (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM xdr3@cdc.gov NR 10 TC 5 Z9 5 U1 0 U2 10 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 19 PY 2014 VL 63 IS 50 BP 1207 EP 1209 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX5DH UT WOS:000346946700007 PM 25522091 ER PT J AU Adam, JK Varan, AK Pong, AL McDonald, EC AF Adam, Jessica K. Varan, Alden K. Pong, Alice L. McDonald, Eric C. TI Fatal Rat-Bite Fever in a Child - San Diego County, California, 2013 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Adam, Jessica K.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Adam, Jessica K.; Varan, Alden K.; McDonald, Eric C.] Cty San Diego Hlth & Human Serv Agcy, San Diego, CA USA. [Adam, Jessica K.; Varan, Alden K.] CDC, Div Global Migrat & Quarantine, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Varan, Alden K.] CDC, Atlanta, GA 30333 USA. [Varan, Alden K.] Council State & Terr Epidemiologists Appl Epidemi, San Diego, CA USA. [Pong, Alice L.] Rady Childrens Hosp, San Diego, CA USA. [Pong, Alice L.] Univ Calif San Diego, Div Pediat Infect Dis, San Diego, CA 92103 USA. RP Adam, JK (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM xdc5@cdc.gov NR 4 TC 0 Z9 0 U1 2 U2 3 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 19 PY 2014 VL 63 IS 50 BP 1210 EP 1211 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX5DH UT WOS:000346946700008 PM 25522092 ER PT J AU Vega, JS Escobedo, M Schulte, CR Rosen, JB Schauer, S Wiseman, R Lippold, SA Regan, JJ AF Vega, Jared S. Escobedo, Miguel Schulte, Cynthia R. Rosen, Jennifer B. Schauer, Stephanie Wiseman, Rachel Lippold, Susan A. Regan, Joanna J. TI Measles Transmission at a Domestic Terminal Gate in an International Airport - United States, January 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Vega, Jared S.; Escobedo, Miguel; Lippold, Susan A.; Regan, Joanna J.] CDC, Div Global Migrat & Quarantine, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Schulte, Cynthia R.] New York State Dept Hlth, Albany, NY 12237 USA. [Rosen, Jennifer B.] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Schauer, Stephanie] Wisconsin Dept Hlth Serv, Madison, WI USA. [Wiseman, Rachel] Texas Dept State Hlth Serv, Austin, TX USA. RP Vega, JS (reprint author), CDC, Div Global Migrat & Quarantine, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM jvega@cdc.gov NR 3 TC 7 Z9 7 U1 0 U2 7 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 19 PY 2014 VL 63 IS 50 BP 1211 EP 1211 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX5DH UT WOS:000346946700009 PM 25522093 ER PT J AU Zhou, ZY Mitchell, RM Gutman, J Wiegand, RE Mwandama, DA Mathanga, DP Skarbinski, J Shi, YP AF Zhou, Zhiyong Mitchell, Rebecca Mans Gutman, Julie Wiegand, Ryan E. Mwandama, Dyson A. Mathanga, Don P. Skarbinski, Jacek Shi, Ya Ping TI Pooled PCR testing strategy and prevalence estimation of submicroscopic infections using Bayesian latent class models in pregnant women receiving intermittent preventive treatment at Machinga District Hospital, Malawi, 2010 SO MALARIA JOURNAL LA English DT Article DE Submicroscopic malaria infection; Nested PCR; Placental histology; IPTp; Pooled sample estimates; Latent class models (LCMs) ID POLYMERASE-CHAIN-REACTION; REAL-TIME PCR; PLASMODIUM-FALCIPARUM INFECTION; PLACENTAL MALARIA; BIRTH-WEIGHT; SULFADOXINE-PYRIMETHAMINE; NEONATAL-MORTALITY; RURAL MALAWI; DIAGNOSIS; MICROSCOPY AB Background: Low malaria parasite densities in pregnancy are a diagnostic challenge. PCR provides high sensitivity and specificity in detecting low density of parasites, but cost and technical requirements limit its application in resources-limited settings. Pooling samples for PCR detection was explored to estimate prevalence of submicroscopic malaria infection in pregnant women at delivery. Previous work uses gold-standard based methods to calculate sensitivity and specificity of tests, creating a challenge when newer methodologies are substantially more sensitive than the gold standard. Thus prevalence was estimated using Bayesian latent class models (LCMs) in this study. Methods: Nested PCR (nPCR) for the 18S rRNA gene subunit of Plasmodium falciparum was conducted to detect malaria infection in microscopy-negative Malawian women on IPTp. Two-step sample pooling used dried blood spot samples (DBSs) collected from placenta or periphery at delivery. Results from nPCR and histology as well as previously published data were used to construct LCMs to estimate assay sensitivity and specificity. Theoretical confidence intervals for prevalence of infection were calculated for two-step and one-step pooling strategies. Results: Of 617 microscopy-negative Malawian women, 39 (6.3%) were identified as actively infected by histology while 52 (8.4%) were positive by nPCR. One hundred forty (22.7%) individuals had past infection assessed by histology. With histology as a reference, 72% of women in the active infection group, 7.1% in the past infection group and 3.2% in histology-negative group were nPCR positive. Using latent class models without a gold standard, histology had a median sensitivity of 49.7% and specificity of 97.6% for active infection while PCR had a median sensitivity of 96.0% and specificity of 99.1%. The true prevalence of active infection was estimated at 8.0% (CI: 5.8-10.5%) from PCR. PCR also had similar sensitivity for detecting either peripheral or placental malaria for submicroscopic infections. One-step pooling would give similar confidence intervals for pool sizes less than 20 while reducing the number of tests performed. Conclusions: Pooled nPCR testing was a sensitive and resource-efficient strategy and LCMs provided precise prevalence estimates of submicroscopic infections. Compared to two-step pooling, one-step pooling could provide similar prevalence estimates at population levels with many fewer tests required. C1 [Zhou, Zhiyong; Mitchell, Rebecca Mans; Gutman, Julie; Wiegand, Ryan E.; Skarbinski, Jacek; Shi, Ya Ping] Ctr Dis Control & Prevent, Malaria Branch, Ctr Global Hlth, Atlanta, GA 30333 USA. [Zhou, Zhiyong; Mitchell, Rebecca Mans; Gutman, Julie; Wiegand, Ryan E.; Skarbinski, Jacek; Shi, Ya Ping] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA USA. [Mwandama, Dyson A.; Mathanga, Don P.] Univ Malawi, Malaria Alert Ctr, Coll Med, Blantyre, Malawi. RP Zhou, ZY (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Ctr Global Hlth, Atlanta, GA 30333 USA. EM zaz6@cdc.gov FU Malaria Branch; Division of Parasitic Diseases and Malaria (DPDM); Center for Global Health (CGH); Centers for Disease Control and Prevention (CDC); US Agency for International Development through the President's Malaria Initiative; Centers for Disease Control and Prevention [3U01CK000135]; University of Malawi, College of Medicine FX This study was supported by Malaria Branch, Division of Parasitic Diseases and Malaria (DPDM), Center for Global Health (CGH), Centers for Disease Control and Prevention (CDC) with additional support from the US Agency for International Development through the President's Malaria Initiative. Data collection in Malawi including the histology testing was supported by the Cooperative Agreement Number 3U01CK000135 between the Centers for Disease Control and Prevention and the University of Malawi, College of Medicine. RMM is an ASM/CDC fellow sponsored by the fellowship programme of American Society of Microbiology. We thank all the local staff in Malawi who participated in sample collection. We also thank Drs. S. Patrick Kachur and Peter McElroy, Malaria Branch and Dr. Laurence Slutsker, DPDM, CGH, CDC for their critical review on this manuscript and valuable suggestions. The findings and conclusions in this paper are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 48 TC 1 Z9 1 U1 1 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 18 PY 2014 VL 13 AR 509 DI 10.1186/1475-2875-13-509 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AY4UZ UT WOS:000347574600001 PM 25522751 ER PT J AU Lyon, GM Mehta, AK Varkey, JB Brantly, K Plyler, L McElroy, AK Kraft, CS Towner, JS Spiropoulou, C Stroher, U Uyeki, TM Ribner, BS AF Lyon, G. Marshall Mehta, Aneesh K. Varkey, Jay B. Brantly, Kent Plyler, Lance McElroy, Anita K. Kraft, Colleen S. Towner, Jonathan S. Spiropoulou, Christina Stroeher, Ute Uyeki, Timothy M. Ribner, Bruce S. CA Emory Serious Communicable Dis TI Clinical Care of Two Patients with Ebola Virus Disease in the United States SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID HEMORRHAGIC-FEVER; INFECTION; FEATURES; KIKWIT; UGANDA; CONGO AB West Africa is currently experiencing the largest outbreak of Ebola virus disease (EVD) in history. Two patients with EVD were transferred from Liberia to our hospital in the United States for ongoing care. Malaria had also been diagnosed in one patient, who was treated for it early in the course of EVD. The two patients had substantial intravascular volume depletion and marked electrolyte abnormalities. We undertook aggressive supportive measures of hydration (typically, 3 to 5 liters of intravenous fluids per day early in the course of care) and electrolyte correction. As the patients' condition improved clinically, there was a concomitant decline in the amount of virus detected in plasma. C1 [Lyon, G. Marshall; Mehta, Aneesh K.; Varkey, Jay B.; Kraft, Colleen S.; Ribner, Bruce S.] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA. [Kraft, Colleen S.] Emory Univ, Sch Med, Dept Pathol, Div Infect Dis, Atlanta, GA 30322 USA. [McElroy, Anita K.] Emory Univ, Sch Med, Dept Pediat, Div Infect Dis, Atlanta, GA USA. [McElroy, Anita K.; Towner, Jonathan S.; Spiropoulou, Christina; Stroeher, Ute; Uyeki, Timothy M.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Brantly, Kent; Plyler, Lance] Samaritans Purse, Boone, NC USA. RP Lyon, GM (reprint author), 101 Woodruff Cir,WMB 2101, Atlanta, GA 30322 USA. EM gmlyon@emory.edu RI Mehta, Aneesh/B-8054-2012 OI Mehta, Aneesh/0000-0002-6552-9162 FU CDC FX Supported by the CDC. NR 21 TC 146 Z9 161 U1 6 U2 79 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 EI 1533-4406 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 18 PY 2014 VL 371 IS 25 BP 2402 EP 2409 DI 10.1056/NEJMoa1409838 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA AW7DX UT WOS:000346425800009 PM 25390460 ER PT J AU Jacobs, J Barbe, B Gillet, P Aidoo, M Serra-Casas, E Van Erps, J Daviaud, J Incardona, S Cunningham, J Visser, T AF Jacobs, Jan Barbe, Barbara Gillet, Philippe Aidoo, Michael Serra-Casas, Elisa Van Erps, Jan Daviaud, Joelle Incardona, Sandra Cunningham, Jane Visser, Theodoor TI Harmonization of malaria rapid diagnostic tests: best practices in labelling including instructions for use SO MALARIA JOURNAL LA English DT Article DE Malaria RDT; Harmonization; Best practices; Labeling; Instructions for use ID PERFORMANCE; MICROSCOPY; SETTINGS AB Background: Rapid diagnostic tests (RDTs) largely account for the scale-up of malaria diagnosis in endemic settings. However, diversity in labelling including the instructions for use (IFU) limits their interchangeability and user-friendliness. Uniform, easy to follow and consistent labelling, aligned with international standards and appropriate for the level of the end user's education and training, is crucial but a consolidated resource of information regarding best practices for IFU and labelling of RDT devices, packaging and accessories is not available. Methods: The Roll Back Malaria Partnership (RBM) commissioned the compilation of international standards and regulatory documents and published literature containing specifications and/or recommendations for RDT design, packaging and labelling of in vitro diagnostics (IVD) (which includes RDTs), complemented with a questionnaire based survey of RDT manufacturers and implementers. A summary of desirable RDT labelling characteristics was compiled, which was reviewed and discussed during a RBM Stakeholder consultation meeting and subsequently amended and refined by a dedicated task force consisting of country programme implementers, experts in RDT implementation, IVD regulatory experts and manufacturers. Results: This process led to the development of consensus documents with a list of suggested terms and abbreviations as well as specifications for labelling of box, device packaging, cassettes, buffer bottle and accessories (lancets, alcohol swabs, transfer devices, desiccants). Emphasis was placed on durability (permanent printing or water-resistant labels), legibility (font size, letter type), comprehension (use of symbols) and ease of reference (e.g. place of labelling on the box or cassette packaging allowing quick oversight). A generic IFU template was developed, comprising background information, a template for procedure and reading/interpretation, a selection of appropriate references and a symbol key of internationally recognized symbols together with suggestions about appropriate lay-out, style and readability. Conclusions: The present document together with its additional files compiled proposes best practices in labelling and IFU for malaria RDTs. It is expected that compliance with these best practices will increase harmonization among the different malaria RDT products available on the market and improve their user-friendliness. C1 [Jacobs, Jan; Barbe, Barbara; Gillet, Philippe; Serra-Casas, Elisa] Inst Trop Med, Dept Clin Sci, B-2000 Antwerp, Belgium. [Jacobs, Jan] Univ Leuven, Dept Microbiol & Immunol, Leuven, KU, Belgium. [Aidoo, Michael] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Malaria Branch, Ctr Global Hlth, Atlanta, GA USA. [Van Erps, Jan] Roll Back Malaria Partnership, Geneva, Switzerland. [Daviaud, Joelle] Global Fund Fight AIDS TB & Malaria, Geneva, Switzerland. [Incardona, Sandra] Fdn Innovat New Diagnost, Geneva, Switzerland. [Cunningham, Jane] WHO, WHO Global Malaria Programme, CH-1211 Geneva, Switzerland. [Visser, Theodoor] Clinton Hlth Access Initiat, Boston, MA USA. RP Jacobs, J (reprint author), Inst Trop Med, Dept Clin Sci, B-2000 Antwerp, Belgium. EM jjacobs@itg.be OI Incardona, Sandra/0000-0003-4994-1736 FU Roll Back Malaria Partnership; Directorate General for Development Cooperation of the Belgian Government through the Network Program on Laboratory Quality Management [3.21] FX This study was funded by Roll Back Malaria Partnership and by the Directorate General for Development Cooperation of the Belgian Government through the Network Program on Laboratory Quality Management, Project 3.21. The funders had no role in the study design, data collection and analysis or the preparation of the manuscript. NR 38 TC 3 Z9 3 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 17 PY 2014 VL 13 AR 505 DI 10.1186/1475-2875-13-505 PG 10 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AY4UT UT WOS:000347574100001 PM 25519980 ER PT J AU Kyeyagalire, R Tempia, S Cohen, AL Smith, AD McAnerney, JM Dermaux-Msimang, V Cohen, C AF Kyeyagalire, Robert Tempia, Stefano Cohen, Adam L. Smith, Adrian D. McAnerney, Johanna M. Dermaux-Msimang, Veerle Cohen, Cheryl TI Hospitalizations associated with influenza and respiratory syncytial virus among patients attending a network of private hospitals in South Africa, 2007 2012 SO BMC INFECTIOUS DISEASES LA English DT Article DE Influenza virus; Respiratory syncytial virus; Hospitalization; South Africa ID UNITED-STATES; PANDEMIC INFLUENZA; SEASONAL INFLUENZA; A(H1N1) INFECTION; TRACT INFECTION; MORTALITY; CHILDREN; SURVEILLANCE; VACCINES; BURDEN AB Background: Influenza and respiratory syncytial virus (RSV) infection are common causes of lower respiratory tract illness. Data on their burden in low and middle-income settings and from Africa are scarce. We aimed to estimate age-specific rates of hospitalization attributable to influenza and RSV among patients attending private hospitals in South Africa during 2007-2012. Methods: We estimated annual age-specific rates of influenza-and RSV-associated hospitalization (that is respiratory hospitalizations likely due to influenza or RSV infection) by applying regression models to monthly administrative hospitalization data from a national private hospital group, using influenza and RSV surveillance data as covariates. Results: Estimated mean hospitalization rates associated with seasonal influenza were 75 (95% confidence interval (CI), 41-108) and 3 (95% CI, 2-5) per 100,000 person-years for all-respiratory and all-circulatory causes, respectively. Children <1 year and adults >= 75 years were the most affected, with influenza-associated all-respiratory hospitalization rates estimated at 255 (95% CI, 143-358) and 380 (95% CI, 227-506) per 100,000 person-years, respectively. Excess all-circulatory hospitalizations associated with seasonal influenza were only observed in adults >= 65 years. Annual hospitalization rates associated with RSV averaged an estimate of 223 (95% CI, 128-317) per 100,000 person-years for all-re spiratory causes. Among children < 1 year, RSV-associated all-respiratory hospitalization rate of 7,601 (95% CI, 4,312-10,817) per 100,000 person-years was estimated. Conclusions: Influenza and RSV substantially contributed to hospitalizations over the study period. C1 [Kyeyagalire, Robert; Smith, Adrian D.] Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England. [Tempia, Stefano; Cohen, Adam L.] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Tempia, Stefano; Cohen, Adam L.] Ctr Dis Control & Prevent, Influenza Div, Pretoria, South Africa. [Tempia, Stefano; McAnerney, Johanna M.; Dermaux-Msimang, Veerle; Cohen, Cheryl] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Ctr Resp Dis & Meningitis, Johannesburg, South Africa. [Cohen, Cheryl] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa. RP Kyeyagalire, R (reprint author), Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England. EM rkyeyagalire@gmail.com FU Li Ka Shing Foundation FX We thank the management of Netcare Limited for providing us access to hospitalization data for their network of private hospitals in South Africa, and the Li Ka Shing Foundation for providing funding to the first author during this study and throughout his MSc programme at the University of Oxford. We also acknowledge the support of Jerome Tokars and Ann Bauman at CDC Atlanta in critically reviewing this article. NR 45 TC 5 Z9 5 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD DEC 16 PY 2014 VL 14 AR 694 DI 10.1186/s12879-014-0694-x PG 10 WC Infectious Diseases SC Infectious Diseases GA AX7YB UT WOS:000347126500001 PM 25510622 ER PT J AU Hu, Y Feng, YY Huang, CC Xiao, LH AF Hu, Yue Feng, Yaoyu Huang, Chengchen Xiao, Lihua TI Occurrence, Source, and Human Infection Potential of Cryptosporidium and Enterocytozoon bieneusi in Drinking Source Water in Shanghai, China, during a Pig Carcass Disposal Incident SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID SURFACE-WATER; SOURCE TRACKING; MOLECULAR CHARACTERIZATION; GIARDIA-DUODENALIS; WASTE-WATER; HEALTH-RISK; SUS-SCROFA; SPP.; PREVALENCE; GENOTYPES AB In March 2013, thousands of domestic pig carcasses were found floating in the Huangpu River, a drinking source water in Shanghai, China. To investigate the impact of the pig carcass incident on microbial water quality, 178 river water samples were collected from the upper Huangpu River from March 2013 to March 2014. Samples were concentrated by calcium carbonate flocculation and examined for host-adapted Cryptosporidium and Enterocytozoon bieneusi by ploymerase chain reaction (PCR). Positive PCR products were sequenced to determine Cryptosporidium species and E. bieneusi genotypes. A total of 67 (37.6%) and 56 (31.5%) samples were PCR-positive for Cryptosporidium and E. bieneusi, respectively. The occurrence rates of Cryptosporidium and E. bieneusi in March 2013 (83.3%; 41.7%) and May 2013 (73.5%; 44.1%) were significantly higher than rates in later sampling times. Among the 13 Cryptosporidium species/genotypes identified, C. andersoni and C. suis were the most common species, being found in 38 and 27 samples, respectively. Seventeen E. bieneusi genotypes were found, belonging to 11 established genotypes (EbpC, EbpA, D, CS-8, PtEb IX, Peru 8, Peru 11, PigEBITS4, EbpB, G, O) and six new ones (RWSH1 to RWSH6), most of which belonged to pig-adapted Groups 1d and 1e. EbpC was the most common genotype, being found in 37 samples. The distribution of Cryptosporidium species and E. bieneusi genotypes suggest that dead pigs contributed significantly to Cryptosporidium and E. bieneusi contamination in the Huangpu River. Although most Cryptosporidium species found in river water were not major human pathogens, the majority of E. bieneusi genotypes detected were endemic in China. Data from this study should be useful in the development of strategies in addressing future contamination events in drinking water supplies. C1 [Hu, Yue; Feng, Yaoyu; Huang, Chengchen] E China Univ Sci & Technol, Sch Resources & Environm Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. [Xiao, Lihua] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Feng, YY (reprint author), E China Univ Sci & Technol, Sch Resources & Environm Engn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China. EM yyfeng@ecust.edu.cn; lxiao@cdc.gov RI Feng, Yaoyu/B-3076-2014; Xiao, Lihua/B-1704-2013 OI Xiao, Lihua/0000-0001-8532-2727 FU National Natural Science Foundation of China [31110103901, 31229005]; National Special Fund for State Key Laboratory of Bioreactor Engineering, China [2060204] FX This work was supported by National Natural Science Foundation of China (31110103901 and 31229005) and National Special Fund for State Key Laboratory of Bioreactor Engineering (No. 2060204), China. NR 67 TC 16 Z9 16 U1 5 U2 31 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 16 PY 2014 VL 48 IS 24 BP 14219 EP 14227 DI 10.1021/es504464t PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AX1CO UT WOS:000346686100021 PM 25383482 ER PT J AU Tanneru, CT Jothikumar, N Hill, VR Chellam, S AF Tanneru, Charan Tej Jothikumar, N. Hill, Vincent R. Chellam, Shankararaman TI Relative Insignificance of Virus Inactivation during Aluminum Electrocoagulation of Saline Waters SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID ELECTROCHEMICAL INACTIVATION; DISINFECTION PROCESSES; STRUCTURAL INTEGRITY; WATERBORNE PATHOGENS; SURFACE-WATER; PILOT-SCALE; Q-BETA; REMOVAL; COAGULATION; MECHANISMS AB Combined removal and inactivation of the MS2 bacteriophage from model saline (0-100 mM NaCl) waters by electrochemical treatment using a sacrificial aluminum anode was evaluated. Both chemical and electrodissolution contributed to coagulant dosing since measured aluminum concentrations were statistically higher than purely electrochemical predictions using Faradays law. Electrocoagulation generated only small amounts of free chlorine in situ but effectively destabilized viruses and incorporated them into Al(OH)(3(s)) flocs during electrolysis. Low chlorine concentrations combined with virus shielding and aggregation within flocs resulted in very slow disinfection rates necessitating extended flocculation/contact times to achieve significant log-inactivation. Therefore, the dominant virus control mechanism during aluminum electrocoagulation of saline waters is physical removal by uptake onto flocs rather than chemical inactivation by chlorine. Attenuated total reflectanceFourier transform infrared spectroscopy provided evidence for oxidative transformations of capsid proteins including formation of oxyacids, aldehydes, and ketones. Electrocoagulation significantly altered protein secondary structures decreasing peak areas associated with turns, bends, a-helices, beta-structures, and random coils for inactivated viruses compared with the MS2 stock. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) measurements showed rapid initial RNA damage following a similar trend as plaque assay measurements of infectious viruses. However, ssRNA cleavage measured by qRT-PCR underestimated inactivation over longer durations. Although aluminum electrocoagulation of saline waters disorders virus capsids and damages RNA, inactivation occurs at a sufficiently low rate so as to only play a secondary role to floc-encapsulation during residence times typical of electrochemical treatment. C1 [Tanneru, Charan Tej; Chellam, Shankararaman] Univ Houston, Dept Civil & Environm Engn, Houston, TX 77204 USA. [Jothikumar, N.; Hill, Vincent R.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30329 USA. [Chellam, Shankararaman] Univ Houston, Dept Chem & Biomol Engn, Houston, TX 77204 USA. RP Chellam, S (reprint author), Univ Houston, Dept Civil & Environm Engn, Houston, TX 77204 USA. EM chellam@uh.edu FU Bureau of Reclamation [R14AS00036]; NSF [CBET-0966939] FX We appreciate funding from the Bureau of Reclamation (R14AS00036) and NSF (CBET-0966939) and anonymous peer-review comments. The findings and conclusions in this manuscript are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or the sponsors. NR 47 TC 6 Z9 6 U1 11 U2 45 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 16 PY 2014 VL 48 IS 24 BP 14590 EP 14598 DI 10.1021/es504381f PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AX1CO UT WOS:000346686100064 PM 25405814 ER PT J AU Makey, CM McClean, MD Sjodin, A Weinberg, J Carignan, CC Webster, TF AF Makey, Colleen M. McClean, Michael D. Sjoedin, Andreas Weinberg, Janice Carignan, Courtney C. Webster, Thomas F. TI Temporal Variability of Polybrominated Diphenyl Ether (PBDE) Serum Concentrations over One Year SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID BROMINATED FLAME RETARDANTS; HUMAN HEALTH-RISKS; IN-HOUSE DUST; ENVIRONMENTAL CONTAMINANTS; POLYCHLORINATED-BIPHENYLS; SEASONAL-VARIATION; LIPID ADJUSTMENT; UNITED-STATES; ASSOCIATIONS; EXPOSURE AB Polybrominated diphenyl ethers (PBDEs) are flame retardant chemicals used in consumer products. They are common contaminants in human serum and associated with adverse health effects. Our objectives were to characterize PBDE serum concentrations in a New England cohort and assess temporal variability of this exposure biomarker over a one-year period. We collected three repeated measurements at six-month intervals from 52 office workers from the greater Boston (MA, United States) area from 2010 to 2011. The intraclass correlation coefficient for BDEs 28, 47, 99, 100, and 153 ranged from 0.87 to 0.99, indicating that a single serum measurement can reliably estimate exposure over a one-year period. This was true for both lipid adjusted and nonlipid adjusted concentrations. The kappa statistics, quantifying the level of agreement of categorical exposure classification, based on medians, tertiles, or quartiles ranged from 0.67 to 0.90. Some congeners showed nonsignificant increases from sampling round 1 (winter) to round 2 (summer) and significant decreases from round 2 to round 3 (winter). This study highlights the high reliability of a single serum PBDE measurement for use in human epidemiologic studies. C1 [Makey, Colleen M.; McClean, Michael D.; Carignan, Courtney C.; Webster, Thomas F.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA. [Sjoedin, Andreas] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Weinberg, Janice; Carignan, Courtney C.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA. [Carignan, Courtney C.] Dartmouth Coll, Dept Biol Sci, Hanover, NH 03755 USA. RP Makey, CM (reprint author), Boston Univ, Sch Publ Hlth, Dept Environm Hlth, 715 Albany St, Boston, MA 02118 USA. EM cmakey@bu.edu RI McClean, Michael/J-2934-2015 FU National Institute of Environmental Health Sciences [R01ES015829, T32ES014562] FX We thank the study participants and Jennifer Ames, Kimberly Burke, Erin Collins, Ashley Miller, Steve Nicholson, and Brittany Weldon for their assistance in sample collection. This work was supported by grants from the National Institute of Environmental Health Sciences: R01ES015829 and T32ES014562. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. NR 42 TC 3 Z9 3 U1 0 U2 32 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 16 PY 2014 VL 48 IS 24 BP 14642 EP 14649 DI 10.1021/es5026118 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA AX1CO UT WOS:000346686100070 PM 25383963 ER PT J AU Wang, ZM Zhu, B Zhang, MF Parikh, H Jia, JP Chung, CC Sampson, JN Hoskins, JW Hutchinson, A Burdette, L Ibrahim, A Hautman, C Raj, PS Abnet, CC Adjei, AA Ahlbom, A Albanes, D Allen, NE Ambrosone, CB Aldrich, M Amiano, P Amos, C Andersson, U Andriole, G Andrulis, IL Arici, C Arslan, AA Austin, MA Baris, D Barkauskas, DA Bassig, BA Freeman, LEB Berg, CD Berndt, SI Bertazzi, PA Biritwum, RB Black, A Blot, W Boeing, H Boffetta, P Bolton, K Boutron-Ruault, MC Bracci, PM Brennan, P Brinton, LA Brotzman, M Bueno-de-Mesquita, HB Buring, JE Butler, MA Cai, QY Cancel-Tassin, G Canzian, F Cao, GW Caporaso, NE Carrato, A Carreon, T Carta, A Chang, GC Chang, IS Chang-Claude, J Che, X Chen, CJ Chen, CY Chen, CH Chen, C Chen, KY Chen, YM Chokkalingam, AP Chu, LW Clavel-Chapelon, F Colditz, GA Colt, JS Conti, D Cook, MB Cortessis, VK Crawford, ED Cussenot, O Davis, FG De Vivo, I Deng, X Ding, T Dinney, CP Di Stefano, AL Diver, WR Duell, EJ Elena, JW Fan, JH Feigelson, HS Feychting, M Figueroa, JD Flanagan, AM Fraumeni, JF Freedman, ND Fridley, BL Fuchs, CS Gago-Dominguez, M Gallinger, S Gao, YT Gapstur, SM Garcia-Closas, M Garcia-Closas, R Gastier-Foster, JM Gaziano, JM Gerhard, DS Giffen, CA Giles, GG Gillanders, EM Giovannucci, EL Goggins, M Gokgoz, N Goldstein, AM Gonzalez, C Gorlick, R Greene, MH Gross, M Grossman, HB Grubb, R Gu, J Guan, P Haiman, CA Hallmans, G Hankinson, SE Harris, CC Hartge, P Hattinger, C Hayes, RB He, QC Helman, L Henderson, BE Henriksson, R Hoffman-Bolton, J Hohensee, C Holly, EA Hong, YC Hoover, RN Hosgood, HD Hsiao, CF Hsing, AW Hsiung, CA Hu, N Hu, W Hu, ZB Huang, MS Hunter, DJ Inskip, PD Ito, H Jacobs, EJ Jacobs, KB Jenab, M Ji, BT Johansen, C Johansson, M Johnson, A Kaaks, R Kamat, AM Kamineni, A Karagas, M Khanna, C Khaw, KT Kim, C Kim, IS Kim, JH Kim, YH Kim, YC Kim, YT Kang, CH Jung, YJ Kitahara, CM Klein, AP Klein, R Kogevinas, M Koh, WP Kohno, T Kolonel, LN Kooperberg, C Kratz, CP Krogh, V Kunitoh, H Kurtz, RC Kurucu, N Lan, Q Lathrop, M Lau, CC Lecanda, F Lee, KM Lee, MP Le Marchand, L Lerner, SP Li, DH Liao, LM Lim, WY Lin, DX Lin, J Lindstrom, S Linet, MS Lissowska, J Liu, JJ Ljungberg, B Lloreta, J Lu, DR Ma, J Malats, N Mannisto, S Marina, N Mastrangelo, G Matsuo, K McGlynn, KA McKean-Cowdin, R McNeill, LH McWilliams, RR Melin, BS Meltzer, PS Mensah, JE Miao, XP Michaud, DS Mondul, AM Moore, LE Muir, K Niwa, S Olson, SH Orr, N Panico, S Park, JY Patel, AV Patino-Garcia, A Pavanello, S Peeters, PHM Peplonska, B Peters, U Petersen, GM Picci, P Pike, MC Porru, S Prescott, J Pu, X Purdue, MP Qiao, YL Rajaraman, P Riboli, E Risch, HA Rodabough, RJ Rothman, N Ruder, AM Ryu, JS Sanson, M Schned, A Schumacher, FR Schwartz, AG Schwartz, KL Schwenn, M Scotlandi, K Seow, A Serra, C Serra, M Sesso, HD Severi, G Shen, HB Shen, M Shete, S Shiraishi, K Shu, XO Siddiq, A Sierrasesumaga, L Sierri, S Sihoe, ADL Silverman, DT Simon, M Southey, MC Spector, L Spitz, M Stampfer, M Stattin, P Stern, MC Stevens, VL Stolzenberg-Solomon, RZ Stram, DO Strom, SS Su, WC Sund, M Sung, SW Swerdlow, A Tan, W Tanaka, H Tang, W Tang, ZZ Tardon, A Tay, E Taylor, PR Tettey, Y Thomas, DM Tirabosco, R Tjonneland, A Tobias, GS Toro, JR Travis, RC Trichopoulos, D Troisi, R Truelove, A Tsai, YH Tucker, MA Tumino, R Van Den Berg, D Van Den Eeden, SK Vermeulen, R Vineis, P Visvanathan, K Vogel, U Wang, CY Wang, CF Wang, JW Wang, SS Weiderpass, E Weinstein, SJ Wentzensen, N Wheeler, W White, E Wiencke, JK Wolk, A Wolpin, BM Wong, MP Wrensch, M Wu, C Wu, TC Wu, XF Wu, YL Wunder, JS Xiang, YB Xu, J Yang, HP Yang, PC Yatabe, Y Ye, YQ Yeboah, ED Yin, ZH Ying, C Yu, CJ Yu, K Yuan, JM Zanetti, KA Zeleniuch-Jacquotte, A Zheng, W Zhou, BS Mirabello, L Savage, SA Kraft, P Chanock, SJ Yeager, M Landi, MT Shi, JX Chatterjee, N Amundadottir, LT AF Wang, Zhaoming Zhu, Bin Zhang, Mingfeng Parikh, Hemang Jia, Jinping Chung, Charles C. Sampson, Joshua N. Hoskins, Jason W. Hutchinson, Amy Burdette, Laurie Ibrahim, Abdisamad Hautman, Christopher Raj, Preethi S. Abnet, Christian C. Adjei, Andrew A. Ahlbom, Anders Albanes, Demetrius Allen, Naomi E. Ambrosone, Christine B. Aldrich, Melinda Amiano, Pilar Amos, Christopher Andersson, Ulrika Andriole, Gerald, Jr. Andrulis, Irene L. Arici, Cecilia Arslan, Alan A. Austin, Melissa A. Baris, Dalsu Barkauskas, Donald A. Bassig, Bryan A. Freeman, Laura E. Beane Berg, Christine D. Berndt, Sonja I. Bertazzi, Pier Alberto Biritwum, Richard B. Black, Amanda Blot, William Boeing, Heiner Boffetta, Paolo Bolton, Kelly Boutron-Ruault, Marie-Christine Bracci, Paige M. Brennan, Paul Brinton, Louise A. Brotzman, Michelle Bueno-de-Mesquita, H. Bas Buring, Julie E. Butler, Mary Ann Cai, Qiuyin Cancel-Tassin, Geraldine Canzian, Federico Cao, Guangwen Caporaso, Neil E. Carrato, Alfredo Carreon, Tania Carta, Angela Chang, Gee-Chen Chang, I-Shou Chang-Claude, Jenny Che, Xu Chen, Chien-Jen Chen, Chih-Yi Chen, Chung-Hsing Chen, Constance Chen, Kuan-Yu Chen, Yuh-Min Chokkalingam, Anand P. Chu, Lisa W. Clavel-Chapelon, Francoise Colditz, Graham A. Colt, Joanne S. Conti, David Cook, Michael B. Cortessis, Victoria K. Crawford, E. David Cussenot, Olivier Davis, Faith G. De Vivo, Immaculata Deng, Xiang Ding, Ti Dinney, Colin P. Di Stefano, Anna Luisa Diver, W. Ryan Duell, Eric J. Elena, Joanne W. Fan, Jin-Hu Feigelson, Heather Spencer Feychting, Maria Figueroa, Jonine D. Flanagan, Adrienne M. Fraumeni, Joseph F., Jr. Freedman, Neal D. Fridley, Brooke L. Fuchs, Charles S. Gago-Dominguez, Manuela Gallinger, Steven Gao, Yu-Tang Gapstur, Susan M. Garcia-Closas, Montserrat Garcia-Closas, Reina Gastier-Foster, Julie M. Gaziano, J. Michael Gerhard, Daniela S. Giffen, Carol A. Giles, Graham G. Gillanders, Elizabeth M. Giovannucci, Edward L. Goggins, Michael Gokgoz, Nalan Goldstein, Alisa M. Gonzalez, Carlos Gorlick, Richard Greene, Mark H. Gross, Myron Grossman, H. Barton Grubb, Robert, III Gu, Jian Guan, Peng Haiman, Christopher A. Hallmans, Goran Hankinson, Susan E. Harris, Curtis C. Hartge, Patricia Hattinger, Claudia Hayes, Richard B. He, Qincheng Helman, Lee Henderson, Brian E. Henriksson, Roger Hoffman-Bolton, Judith Hohensee, Chancellor Holly, Elizabeth A. Hong, Yun-Chul Hoover, Robert N. Hosgood, H. Dean Hsiao, Chin-Fu Hsing, Ann W. Hsiung, Chao Agnes Hu, Nan Hu, Wei Hu, Zhibin Huang, Ming-Shyan Hunter, David J. Inskip, Peter D. Ito, Hidemi Jacobs, Eric J. Jacobs, Kevin B. Jenab, Mazda Ji, Bu-Tian Johansen, Christoffer Johansson, Mattias Johnson, Alison Kaaks, Rudolf Kamat, Ashish M. Kamineni, Aruna Karagas, Margaret Khanna, Chand Khaw, Kay-Tee Kim, Christopher Kim, In-Sam Kim, Jin Hee Kim, Yeul Hong Kim, Young-Chul Kim, Young Tae Kang, Chang Hyun Jung, Yoo Jin Kitahara, Cari M. Klein, Alison P. Klein, Robert Kogevinas, Manolis Koh, Woon-Puay Kohno, Takashi Kolonel, Laurence N. Kooperberg, Charles Kratz, Christian P. Krogh, Vittorio Kunitoh, Hideo Kurtz, Robert C. Kurucu, Nilgun Lan, Qing Lathrop, Mark Lau, Ching C. Lecanda, Fernando Lee, Kyoung-Mu Lee, Maxwell P. Le Marchand, Loic Lerner, Seth P. Li, Donghui Liao, Linda M. Lim, Wei-Yen Lin, Dongxin Lin, Jie Lindstrom, Sara Linet, Martha S. Lissowska, Jolanta Liu, Jianjun Ljungberg, Boerje Lloreta, Josep Lu, Daru Ma, Jing Malats, Nuria Mannisto, Satu Marina, Neyssa Mastrangelo, Giuseppe Matsuo, Keitaro McGlynn, Katherine A. McKean-Cowdin, Roberta McNeill, Lorna H. McWilliams, Robert R. Melin, Beatrice S. Meltzer, Paul S. Mensah, James E. Miao, Xiaoping Michaud, Dominique S. Mondul, Alison M. Moore, Lee E. Muir, Kenneth Niwa, Shelley Olson, Sara H. Orr, Nick Panico, Salvatore Park, Jae Yong Patel, Alpa V. Patino-Garcia, Ana Pavanello, Sofia Peeters, Petra H. M. Peplonska, Beata Peters, Ulrike Petersen, Gloria M. 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Tirabosco, Roberto Tjonneland, Anne Tobias, Geoffrey S. Toro, Jorge R. Travis, Ruth C. Trichopoulos, Dimitrios Troisi, Rebecca Truelove, Ann Tsai, Ying-Huang Tucker, Margaret A. Tumino, Rosario Van Den Berg, David Van Den Eeden, Stephen K. Vermeulen, Roel Vineis, Paolo Visvanathan, Kala Vogel, Ulla Wang, Chaoyu Wang, Chengfeng Wang, Junwen Wang, Sophia S. Weiderpass, Elisabete Weinstein, Stephanie J. Wentzensen, Nicolas Wheeler, William White, Emily Wiencke, John K. Wolk, Alicja Wolpin, Brian M. Wong, Maria Pik Wrensch, Margaret Wu, Chen Wu, Tangchun Wu, Xifeng Wu, Yi-Long Wunder, Jay S. Xiang, Yong-Bing Xu, Jun Yang, Hannah P. Yang, Pan-Chyr Yatabe, Yasushi Ye, Yuanqing Yeboah, Edward D. Yin, Zhihua Ying, Chen Yu, Chong-Jen Yu, Kai Yuan, Jian-Min Zanetti, Krista A. Zeleniuch-Jacquotte, Anne Zheng, Wei Zhou, Baosen Mirabello, Lisa Savage, Sharon A. Kraft, Peter Chanock, Stephen J. Yeager, Meredith Landi, Maria Terese Shi, Jianxin Chatterjee, Nilanjan Amundadottir, Laufey T. TI Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33 SO HUMAN MOLECULAR GENETICS LA English DT Article ID GENOME-WIDE ASSOCIATION; SINGLE-NUCLEOTIDE POLYMORPHISM; POSTMENOPAUSAL BREAST-CANCER; TERT PROMOTER MUTATIONS; 2 SUSCEPTIBILITY LOCI; TELOMERE LENGTH; LUNG-CANCER; PROSTATE-CANCER; PANCREATIC-CANCER; DNA METHYLATION AB Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 x 10(-39); Region 3: rs2853677, P = 3.30 x 10(-36) and P-Conditional = 2.36 x 10(-8); Region 4: rs2736098, P = 3.87 x 10(-12) and P-Conditional = 5.19 x 10(-6), Region 5: rs13172201, P = 0.041 and P-Conditional = 2.04 x 10(-6); and Region 6: rs10069690, P = 7.49 x 10 215 and P-Conditional = 5.35 x 10(-7)) and one in the neighboring CLPTM1L gene(Region 2: rs451360; P = 1.90 x 10(-18) and P-Conditional = 7.06 x 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci. C1 [Wang, Zhaoming; Zhu, Bin; Zhang, Mingfeng; Parikh, Hemang; Jia, Jinping; Chung, Charles C.; Sampson, Joshua N.; Hoskins, Jason W.; Hutchinson, Amy; Burdette, Laurie; Ibrahim, Abdisamad; Hautman, Christopher; Raj, Preethi S.; Abnet, Christian C.; Albanes, Demetrius; Baris, Dalsu; Bassig, Bryan A.; Freeman, Laura E. 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[Kolonel, Laurence N.; Le Marchand, Loic] Univ Hawaii, Program Epidemiol, Ctr Canc, Honolulu, HI 96822 USA. [Krogh, Vittorio] Fdn IRCCS Ist Nazl Tumori, Milan, Italy. [Kunitoh, Hideo] Mitsui Mem Hosp, Dept Resp Med, Tokyo 101, Japan. [Kurucu, Nilgun] AY Ankara Oncol Training & Res Hosp, Dept Pediat Oncol, Yenimahalle Ankara, Turkey. [Lathrop, Mark] IG CEA, Ctr Natl Genotypage, Evry, France. [Lathrop, Mark] CEPH, Paris, France. [Lau, Ching C.] Baylor Coll Med, Texas Childrens Canc Ctr, Houston, TX 77030 USA. [Lau, Ching C.] Baylor Coll Med, Hematol Ctr, Houston, TX 77030 USA. [Lerner, Seth P.] Baylor Coll Med, Scott Dept Urol, Houston, TX 77030 USA. [Spitz, Margaret] Baylor Coll Med, Dan L Duncan Ctr, Houston, TX 77030 USA. [Spitz, Margaret] Baylor Coll Med, Dan L Duncan Ctr, Houston, TX 77030 USA. [Lecanda, Fernando; Patino-Garcia, Ana; Sierrasesumaga, Luis] Univ Navarra, Univ Navarra Clin, Dept Pediat, E-31080 Pamplona, Spain. [Lissowska, Jolanta] Maria Sklodowska Curie Canc Ctr, Dept Canc Epidemiol & Prevent, Warsaw, Poland. [Lissowska, Jolanta] Inst Oncol, Warsaw, Poland. [Liu, Jianjun] Genome Inst Singapore, Div Human Genet, Singapore, Singapore. [Liu, Jianjun] Anhui Med Univ, Sch Life Sci, Hefei, Peoples R China. [Lu, Daru] Fudan Univ, Minist Educ, Key Lab Contemporary Anthropol, Sch Life Sci, Shanghai 200433, Peoples R China. [Lu, Daru] Fudan Univ, State Key Lab Genet Engn, Sch Life Sci, Shanghai 200433, Peoples R China. [Malats, Nuria] Ctr Nacl Invest Oncol, E-28029 Madrid, Spain. [Mannisto, Satu] Natl Inst Hlth & Welf, Helsinki, Finland. [Marina, Neyssa] Stanford Univ, Lucile Packard Childrens Hosp, Palo Alto, CA 94304 USA. [Mastrangelo, Giuseppe; Pavanello, Sofia; Wu, Tangchun] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Padua, Italy. [Matsuo, Keitaro] Kyushu Univ, Dept Prevent Med, Fac Med Sci, Fukuoka 812, Japan. [McWilliams, Robert R.; Petersen, Gloria M.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA. [Miao, Xiaoping] Huazhong Univ Sci & Technol, Key Lab Environm & Hlth, Sch Publ Hlth, Tongji Med Coll, Wuhan 430074, Peoples R China. [Michaud, Dominique S.] Brown Univ, Div Biol & Med, Dept Epidemiol, Providence, RI 02912 USA. [Muir, Kenneth] Univ Warwick, Hlth Sci Res Inst, Coventry CV4 7AL, W Midlands, England. [Orr, Nick] Inst Canc Res, Complex Traits Genet Team, London SW3 6JB, England. [Swerdlow, Anthony] Inst Canc Res, Div Breast Canc Res, London SW3 6JB, England. [Panico, Salvatore] Univ Naples Federico II, Dipartimento Med Clin & Chirurgia, Naples, Italy. [Park, Jae Yong] Kyungpook Natl Univ, Lung Canc Ctr, Med Ctr, Taegu, South Korea. [Peeters, Petra H. M.] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [Peeters, Petra H. M.; Riboli, Elio] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England. [Siddiq, Afshan] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Genom Common Dis, London, England. [Peplonska, Beata] Nofer Inst Occupat Med, Lodz, Poland. [Qiao, You-Lin] Chinese Acad Med Sci, Dept Epidemiol, Canc Inst Hosp, Beijing 100730, Peoples R China. [Risch, Harvey A.] Yale Univ, Sch Publ Hlth, New Haven, CT USA. [Ryu, Jeong-Seon] Inha Univ, Coll Med, Dept Internal Med, Inchon, South Korea. [Schwartz, Ann G.] Wayne State Univ, Karmanos Canc Inst, Detroit, MI USA. [Schwartz, Ann G.] Wayne State Univ, Dept Oncol, Detroit, MI USA. [Schwartz, Kendra L.] Wayne State Univ, Sch Med, Karmanos Canc Inst, Detroit, MI USA. [Schwartz, Kendra L.] Wayne State Univ, Sch Med, Dept Family Med & Publ Hlth Sci, Detroit, MI USA. [Schwenn, Molly] Maine Canc Registry, Augusta, ME USA. [Serra, Consol] Univ Pompeu Fabra, Ctr Res Occupat Hlth, Barcelona, Spain. [Peeters, Petra H. M.; Riboli, Elio] Univ Texas MD Anderson Canc Ctr, CIBER Epidemiol & Publ Hlth CIBERESP, Houston, TX 77030 USA. [Siddiq, Afshan] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA. [Sierri, Sabina] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy. [Sihoe, Alan Dart Loon] Queen Mary Hosp, Dept Surg, Div Cardiothorac Surg, Hong Kong, Hong Kong, Peoples R China. [Simon, Matthias] Univ Bonn, Med Ctr, Dept Neurosurg, Bonn, Germany. [Southey, Melissa C.] Univ Melbourne, Dept Pathol, Melbourne, Vic, Australia. [Spector, Logan] Univ Minnesota, Minneapolis, MN USA. [Su, Wu-Chou; Yu, Chong-Jen] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 70428, Taiwan. [Su, Wu-Chou; Yu, Chong-Jen] Natl Cheng Kung Univ, Coll Med, Tainan 70101, Taiwan. [Tardon, Adonina] Univ Oviedo, Inst Univ Oncol, Oviedo, Spain. [Thomas, David M.] Univ Melbourne, Sir Peter MacCallum Dept Oncol, East Melbourne, Vic, Australia. [Tjonneland, Anne] Danish Canc Soc, Res Ctr, Copenhagen, Denmark. [Tsai, Ying-Huang] Chang Gung Mem Hosp, Dept Pulm Med, Chiayi, Taiwan. [Tumino, Rosario] Canc Registry Assoc Iblea Ric Epidemiol, Ragusa, Italy. [Van Den Eeden, Stephen K.] Kaiser Permanente No Calif, Oakland, CA USA. [Vermeulen, Roel] Univ Utrecht, Div Environm Epidemiol, Inst Risk Assessment Sci IRAS, Utrecht, Netherlands. [Vineis, Paolo] Univ London Imperial Coll Sci Technol & Med, London, England. [Vineis, Paolo] Human Genet Fdn HuGeF, Turin, Italy. [Vogel, Ulla] Natl Res Ctr Working Environm, Copenhagen, Denmark. [Vogel, Ulla] Tech Univ Denmark, Natl Food Inst, Soborg, Denmark. [Wang, Junwen] Univ Hong Kong, Dept Biochem, Hong Kong, Hong Kong, Peoples R China. [Wang, Junwen] Univ Hong Kong, Ctr Genom Sci, LKS Fac Med, Hong Kong, Hong Kong, Peoples R China. [Wong, Maria Pik] Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China. [Xu, Jun] Univ Hong Kong, Sch Publ Hlth, Li Ka Shing LKS Fac Med, Hong Kong, Hong Kong, Peoples R China. [Wang, Sophia S.] City Hope Natl Med Ctr, Dept Populat Sci, Div Canc Etiol, Duarte, CA USA. [Wang, Sophia S.] City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USA. [Weiderpass, Elisabete] Arct Univ Norway, Dept Community Med, Fac Hlth Sci, Univ Tromso, Tromso, Norway. [Weiderpass, Elisabete] Canc Registry Norway, Dept Res, Oslo, Norway. [Weiderpass, Elisabete] Samfundet Folkhalsan, Helsinki, Finland. [Wiencke, John K.; Wrensch, Margaret] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Wu, Yi-Long] Guangdong Acad Med Sci, Med Res Ctr, Guangdong Lung Canc Inst, Guangzhou, Guangdong, Peoples R China. [Wu, Yi-Long] Guangdong Acad Med Sci, Ctr Canc, Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China. [Yatabe, Yasushi] Aichi Canc Ctr Hosp, Dept Pathol & Mol Diagnost, Pittsburgh, PA USA. [Yuan, Jian-Min] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA. [Lee, Kyoung-Mu] Korea Natl Open Univ, Dept Environm Hlth, Seoul, South Korea. RP Amundadottir, LT (reprint author), NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, Adv Technol Ctr, 8717 Grovemont Circle, Bethesda, MD 20892 USA. EM amundadottirl@mail.nih.gov RI Abnet, Christian/C-4111-2015; Malats, Nuria/H-7041-2015; Chen, Chien-Jen/C-6976-2008; Patino-Garcia, Ana/I-4299-2012; Tucker, Margaret/B-4297-2015; Simon, Matthias/F-3046-2014; Cook, Michael/A-5641-2009; Purdue, Mark/C-9228-2016; Savage, Sharon/B-9747-2015; Tanaka, Hideo/A-8145-2016; Krogh, Vittorio/K-2628-2016; Panico, Salvatore/K-6506-2016; Amundadottir, Laufey/L-7656-2016; Gallinger, Steven/E-4575-2013; Albanes, Demetrius/B-9749-2015; Hsiao, Chin-Fu/E-3993-2010; Boutron-Ruault, Marie-Christine/H-3936-2014; Brinton, Louise/G-7486-2015; Freedman, Neal/B-9741-2015; Beane Freeman, Laura/C-4468-2015; miao, xiaoping/C-4336-2011; Andrulis, Irene/E-7267-2013; Fridley, Brooke/D-8315-2015; Hsiung, Chao Agnes/E-3994-2010; Garcia-Closas, Montserrat /F-3871-2015; Chang, I-Shou/D-2084-2010; Serra, Massimo/J-4878-2016; Tobias, Geoffrey/M-4135-2016; Weiderpass, Elisabete/M-4029-2016; Hattinger, Claudia/Q-1212-2016; Kitahara, Cari/R-8267-2016; Jung, Yoojin/G-2519-2015; Kogevinas, Manolis/C-3918-2017; Vermeulen, Roel/F-8037-2011; bertazzi, pietro alberto/D-5039-2017; Vogel, Ulla/I-5048-2012; Wang, Junwen/D-3700-2011; OI Abnet, Christian/0000-0002-3008-7843; Malats, Nuria/0000-0003-2538-3784; Cook, Michael/0000-0002-0533-7302; Purdue, Mark/0000-0003-1177-3108; Savage, Sharon/0000-0001-6006-0740; Krogh, Vittorio/0000-0003-0122-8624; Panico, Salvatore/0000-0002-5498-8312; Amundadottir, Laufey/0000-0003-1859-8971; Brinton, Louise/0000-0003-3853-8562; Freedman, Neal/0000-0003-0074-1098; Beane Freeman, Laura/0000-0003-1294-4124; miao, xiaoping/0000-0002-6818-9722; Fridley, Brooke/0000-0001-7739-7956; Garcia-Closas, Montserrat /0000-0003-1033-2650; Serra, Massimo/0000-0003-0742-1177; Tobias, Geoffrey/0000-0002-2878-8253; Weiderpass, Elisabete/0000-0003-2237-0128; Hattinger, Claudia/0000-0002-9316-5095; Vermeulen, Roel/0000-0003-4082-8163; bertazzi, pietro alberto/0000-0003-3475-2449; Duell, Eric J/0000-0001-5256-0163; Vogel, Ulla/0000-0001-6807-1524; Mondul, Alison/0000-0002-8843-1416; Hayes, Richard/0000-0002-0918-661X; Qiao, You-Lin/0000-0001-6380-0871; Giles, Graham/0000-0003-4946-9099; Zeleniuch-Jacquotte, Anne/0000-0001-9350-1303; Cancel-Tassin, Geraldine/0000-0002-9583-6382; Spector, Logan/0000-0003-2516-0222; Wang, Junwen/0000-0002-4432-4707; Liao, Linda/0000-0002-1923-5294; Hoskins, Jason/0000-0001-6944-1996 FU US National Institutes of Health (NIH), National Cancer Institute [HHSN261200800001E]; Intramural Research Program FX This work was supported by the Intramural Research Program and by contract number HHSN261200800001E of the US National Institutes of Health (NIH), National Cancer Institute. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services nor does mention of trade names, commercial products or organizations imply endorsement by the U.S. Government. Additional funding acknowledgements are listed in Supplementary Material. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. NR 89 TC 25 Z9 25 U1 6 U2 59 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0964-6906 EI 1460-2083 J9 HUM MOL GENET JI Hum. Mol. Genet. PD DEC 15 PY 2014 VL 23 IS 24 BP 6616 EP 6633 DI 10.1093/hmg/ddu363 PG 18 WC Biochemistry & Molecular Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Genetics & Heredity GA AZ0FP UT WOS:000347921900017 PM 25027329 ER PT J AU Caughey, MC Avery, CL Ni, HY Solomon, SD Matsushita, K Wruck, LM Rosamond, WD Loehr, LR AF Caughey, Melissa C. Avery, Christy L. Ni, Hanyu Solomon, Scott D. Matsushita, Kunihiro Wruck, Lisa M. Rosamond, Wayne D. Loehr, Laura R. TI Outcomes of Patients With Anemia and Acute Decompensated Heart Failure With Preserved Versus Reduced Ejection Fraction (from the ARIC Study Community Surveillance) SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID MORTALITY; HEMOGLOBIN; HOSPITALIZATION; PREVALENCE; MANAGEMENT; MORBIDITY; REGISTRY; DISEASE; COMMON; DEATH AB Anemia is associated with poor prognosis in patients hospitalized with acute decompensated heart failure (ADHF). Whether the impact of anemia differs by heart failure with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction (HFrEF) is uncertain. We examined hospital surveillance data captured by the Atherosclerosis Risk in Communities Study from January 1, 2005, to December 31, 2010. Diagnoses of ADHF were validated by standardized physician review of the medical record. Anemia was classified using the World Health Organization criteria (<12 g/dl for women and <13 g/dl for men), and HF type was determined by the ejection fraction (<40% for HFrEF and >= 40% for HFpEF). Hospital length of stay and 1-year mortality outcomes were analyzed by multivariable regression, weighted to account for the sampling design, and adjusted for demographics and clinical covariates. Over 6 years, 15,461 (weighted) hospitalized events for ADHF (59% HFrEF) occurred in the catchment of the Atherosclerosis Risk in Communities, based on 3,309 sampled events. Anemia was associated with a mortality hazard ratio of 2.1 (95% confidence interval [CI] 1.6 to 2.7) in patients classified with HFpEF and 1.4 (95% CI 1.1 to 1.7) in those with HFrEF; p for interaction = 0.05. The mean increase in length of hospital stay associated with anemia was 3.5 days (95% CI 3.4 to 3.6) for patients with HFpEF, compared with 1.8 days (95% CI 1.7 to 1.9) for those with HFrEF; p for interaction <0.0001. In conclusion, the incremental risks of death and lengthened hospital stay associated with anemia are more pronounced in ADHF patients classified with HFpEF than HFrEF. (C) 2014 Elsevier Inc. All rights reserved. C1 [Caughey, Melissa C.] Univ N Carolina, Dept Med, Chapel Hill, NC 27515 USA. [Caughey, Melissa C.; Avery, Christy L.; Wruck, Lisa M.; Rosamond, Wayne D.; Loehr, Laura R.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. [Ni, Hanyu] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Solomon, Scott D.] Harvard Univ, Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA. [Matsushita, Kunihiro] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. RP Caughey, MC (reprint author), Univ N Carolina, Dept Med, Chapel Hill, NC 27515 USA. EM caughey@med.unc.edu FU National Heart, Lung, and Blood Institute [HHSN268201100005C, HSN268201100006C, HHSN268201100007C, HHSN268201100008C, HSN268201100009C, HHSN268201100010C, HHSN268201100011C, SN268201100012C]; [R00-HL098458] FX The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by the National Heart, Lung, and Blood Institute contracts HHSN268201100005C, HSN268201100006C, HHSN268201100007C, HHSN268201100008C, HSN268201100009C, HHSN268201100010C, HHSN268201100011C, and SN268201100012C. Caughey was supported by grant R00-HL098458. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have no conflicts of interest to disclose. NR 24 TC 9 Z9 10 U1 2 U2 4 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9149 EI 1879-1913 J9 AM J CARDIOL JI Am. J. Cardiol. PD DEC 15 PY 2014 VL 114 IS 12 BP 1850 EP 1854 DI 10.1016/j.amjcard.2014.09.024 PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA AX4ET UT WOS:000346887300011 PM 25438912 ER PT J AU Stockwell, MS Reed, C Vargas, CY Camargo, S Garretson, AF Alba, LR LaRussa, P Finelli, L Larson, EL Saiman, L AF Stockwell, Melissa S. Reed, Carrie Vargas, Celibell Y. Camargo, Stewin Garretson, Aaron F. Alba, Luis R. LaRussa, Philip Finelli, Lyn Larson, Elaine L. Saiman, Lisa TI MoSAIC: Mobile Surveillance for Acute Respiratory Infections and Influenza-Like Illness in the Community SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE acute respiratory infection; influenza; influenza-like illness; respiratory viruses; surveillance; text messaging ID SENTINEL SURVEILLANCE; PANDEMIC INFLUENZA; HOUSEHOLD; OUTBREAK; VACCINE; COHORT; VIRUS; US AB Surveillance for acute respiratory infection (ARI) and influenza-like illness (ILI) relies primarily on reports of medically attended illness. Community surveillance could mitigate delays in reporting, allow for timely collection of respiratory tract samples, and characterize cases of non-medically attended ILI representing substantial personal and economic burden. Text messaging could be utilized to perform longitudinal ILI surveillance in a community-based sample but has not been assessed. We recruited 161 households (789 people) in New York City for a study of mobile ARI/ILI surveillance, and selected reporters received text messages twice weekly inquiring whether anyone in the household was ill. Home visits were conducted to obtain nasal swabs from persons with ARI/ILI. Participants were primarily female, Latino, and publicly insured. During the 44-week period from December 2012 through September 2013, 11,282 text messages were sent. In responses to 8,250 (73.1%) messages, a household reported either that someone was ill or no one was ill; 88.9% of responses were received within 4 hours. Swabs were obtained for 361 of 363 reported ARI/ILI episodes. The median time from symptom onset to nasal swab was 2 days; 65.4% of samples were positive for a respiratory pathogen by reverse-transcriptase polymerase chain reaction. In summary, text messaging promoted rapid ARI/ILI reporting and specimen collection and could represent a promising approach to timely, community-based surveillance. C1 [Stockwell, Melissa S.; Vargas, Celibell Y.; Camargo, Stewin] Columbia Univ, Div Child & Adolescent Hlth, Dept Pediat, Coll Phys & Surg, New York, NY 10032 USA. [Stockwell, Melissa S.] Columbia Univ, Dept Populat & Family Hlth, Mailman Sch Publ Hlth, New York, NY 10032 USA. [Stockwell, Melissa S.] NewYork Presbyterian Hosp, New York, NY USA. [Reed, Carrie; Finelli, Lyn] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA. [Garretson, Aaron F.; Alba, Luis R.; LaRussa, Philip; Saiman, Lisa] Columbia Univ, Div Pediat Infect Dis, Dept Pediat, Coll Phys & Surg, New York, NY 10032 USA. [Larson, Elaine L.] Columbia Univ, Sch Nursing, Dept Nursing Scholarship & Res, New York, NY 10032 USA. [Larson, Elaine L.] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY 10032 USA. [Saiman, Lisa] NewYork Presbyterian Hosp, Dept Infect Prevent & Control, New York, NY USA. RP Stockwell, MS (reprint author), Columbia Univ, Div Child & Adolescent Hlth, Dept Pediat, Coll Phys & Surg,Vanderbilt Clin 417, 622 West 168th St, New York, NY 10032 USA. EM mss2112@columbia.edu FU Centers for Disease Control and Prevention [U01IP000618] FX This study was funded by grant U01IP000618 from the Centers for Disease Control and Prevention. NR 32 TC 5 Z9 5 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 EI 1476-6256 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD DEC 15 PY 2014 VL 180 IS 12 BP 1196 EP 1201 DI 10.1093/aje/kwu303 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AW6ZN UT WOS:000346414300009 PM 25416593 ER PT J AU Howard, DH Guy, GP Ekwueme, DU AF Howard, David H. Guy, Gery P., Jr. Ekwueme, Donatus U. TI Eliminating Cost-Sharing Requirements for Colon Cancer Screening in Medicare SO CANCER LA English DT Editorial Material DE cancer screening; colorectal cancer; health insurance; health reform; Medicare ID COLONOSCOPY; POPULATION AB Medicare beneficiaries do not have to pay for screening colonoscopies but must pay coinsurance if a polyp is removed via polypectomy. Likewise, beneficiaries do not have to pay for fecal occult blood tests but are liable for cost-sharing for diagnostic colonoscopies after a positive test. Legislative and regulatory requirements related to colorectal cancer screening are described, and on the basis of Medicare claims, it is estimated that Medicare spending would increase by $48 million annually if Medicare were to waive cost-sharing requirements for these services. The economic impact on Medicare if beneficiaries were not responsible for any cost-sharing requirements related to colorectal cancer screening services is described. Cancer 2014;120:3850-3852. (c) 2014 American Cancer Society. Medicare beneficiaries incur out-of-pocket costs for polypectomies and colonoscopies after a positive fecal occult blood test. We estimate Medicare spending will increase by $48 million annually if Medicare waives cost-sharing requirements for these services. C1 [Howard, David H.] Emory Univ, Dept Hlth Policy & Management, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA. [Howard, David H.] Emory Univ, Winship Canc Ctr, Atlanta, GA 30322 USA. [Guy, Gery P., Jr.; Ekwueme, Donatus U.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. RP Howard, DH (reprint author), Emory Univ, Dept Hlth Policy & Management, Rollins Sch Publ Hlth, 1518 Clifton Rd NE, Atlanta, GA 30322 USA. EM david.howard@emory.edu FU Intramural CDC HHS [CC999999]; PHS HHS [12IPA1203126] NR 8 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD DEC 15 PY 2014 VL 120 IS 24 BP 3850 EP 3852 DI 10.1002/cncr.29093 PG 3 WC Oncology SC Oncology GA AW1TX UT WOS:000346074300004 PM 25302786 ER PT J AU Holzbauer, SM Agger, WA Hall, RL Johnson, GM Schmitt, D Garvey, A Bishop, HS Rivera, H de Almeida, ME Hill, D Stromberg, BE Lynfield, R Smith, KE AF Holzbauer, Stacy M. Agger, William A. Hall, Rebecca L. Johnson, Gary M. Schmitt, David Garvey, Ann Bishop, Henry S. Rivera, Hilda de Almeida, Marcos E. Hill, Dolores Stromberg, Bert E. Lynfield, Ruth Smith, Kirk E. TI Outbreak of Trichinella spiralis Infections Associated With a Wild Boar Hunted at a Game Farm in Iowa SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE human trichinellosis; outbreak; Trichinella spiralis; pork; wild boar ID HUMAN TRICHINOSIS; LARVAE; BRITOVI; HUMANS; MEAT AB Background. Rates of trichinellosis have declined significantly in the United States due to improved pork production practices and public awareness of the danger of eating raw or undercooked pork. In April 2011, the Minnesota Department of Health received a report of presumptive trichinellosis in a 50-year-old man with a history of wild boar consumption. A public health investigation was initiated. Methods. Medical record reviews and patient and family interviews were conducted. Trichinella species serology was performed on patient and family serum samples, and larval identification was attempted on clinical specimens and meat samples. Results. The index patient harvested a wild boar from an Iowa game farm; he processed the meat after returning home and developed gastrointestinal symptoms 2 days later. Four days after his illness onset, all 5 family members consumed a roast from the boar. The index patient sought healthcare 4 times after illness onset before being definitively diagnosed with trichinellosis. Following initiation of albendazole therapy, the index patient developed atrial fibrillation. One additional family member who processed the raw meat was diagnosed with trichinellosis. Trichinella spiralis larvae were identified in wild boar meat samples. Conclusions. Trichinellosis has long been recognized as a potential hazard of consuming undercooked wild carnivore meat, and historically has been associated with consumption of pork from domestic swine, but may be unfamiliar to practicing clinicians in the United States. Education of hunters and the broader population on the potential for trichinellosis and the importance of proper handling and cooking meat from wild or free-range animals needs to be reinforced. C1 [Holzbauer, Stacy M.] Ctr Dis Control & Prevent, Div State & Local Readiness, Off Publ Hlth Preparedness & Response, Atlanta, GA USA. [Holzbauer, Stacy M.; Lynfield, Ruth; Smith, Kirk E.] Minnesota Dept Hlth, St Paul, MN USA. [Agger, William A.] Gunderson Med Fdn, La Crosse, WI USA. [Hall, Rebecca L.; Bishop, Henry S.; Rivera, Hilda; de Almeida, Marcos E.] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Parasit Dis & Malaria, Atlanta, GA USA. [Johnson, Gary M.; Schmitt, David] Iowa Dept Agr & Land Stewardship, Des Moines, IA USA. [Garvey, Ann] Iowa Dept Publ Hlth, Des Moines, IA 50319 USA. [Hill, Dolores] ARS, USDA, Beltsville, MD USA. [Stromberg, Bert E.] Univ Minnesota, Coll Vet Med, Dept Vet & Biomed Sci, St Paul, MN 55108 USA. RP Holzbauer, SM (reprint author), 625 Robert St N, St Paul, MN 55164 USA. EM stacy.holzbauer@state.mn.us NR 31 TC 5 Z9 5 U1 4 U2 24 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2014 VL 59 IS 12 BP 1750 EP 1756 DI 10.1093/cid/ciu713 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AU9KM UT WOS:000345911500020 PM 25214511 ER PT J AU Rasmussen, SA Hernandez-Diaz, S Abdul-Rahman, OA Sahin, L Petrie, CR Keppler-Noreuil, KM Frey, SE Mason, RM Nesin, M Carey, JC AF Rasmussen, Sonja A. Hernandez-Diaz, Sonia Abdul-Rahman, Omar A. Sahin, Leyla Petrie, Carey R. Keppler-Noreuil, Kim M. Frey, Sharon E. Mason, Robin M. Nesin, Mirjana Carey, John C. TI Assessment of Congenital Anomalies in Infants Born to Pregnant Women Enrolled in Clinical Trials SO CLINICAL INFECTIOUS DISEASES LA English DT Article DE congenital anomalies; birth defects; clinical trials; pregnant women ID MORPHOLOGY STANDARD TERMINOLOGY; FETAL ALCOHOL SYNDROME; BIRTH-DEFECTS; POSTMARKETING SURVEILLANCE; MAJOR MALFORMATIONS; EXCLUSION CRITERIA; TERATOGEN UPDATE; PREDICTIVE VALUE; NEWBORN-INFANTS; MINOR ANOMALIES AB In 2011 and 2012, the Division of Microbiology and Infectious Diseases at the National Institute of Allergy and Infectious Diseases, National Institutes of Health, held a series of meetings to provide guidance to investigators regarding study design of clinical trials of vaccines and antimicrobial medications that enroll pregnant women. Assessment of congenital anomalies among infants born to women enrolled in these trials was recognized as a challenging issue, and a workgroup with expertise in epidemiology, pediatrics, genetics, dysmorphology, clinical trials, and infectious diseases was formed to address this issue. The workgroup considered 3 approaches for congenital anomalies assessment that have been developed for use in other studies: (1) maternal report combined with medical records review, (2) standardized photographic assessment and physical examination by a health professional who has received specific training in congenital anomalies, and (3) standardized physical examination by a trained dysmorphologist (combined with maternal interview and medical records review). The strengths and limitations of these approaches were discussed with regard to their use in clinical trials. None of the approaches was deemed appropriate for use in all clinical trials. Instead, the workgroup acknowledged that decisions regarding the optimal method of assessment of congenital anomalies will likely vary depending on the clinical trial, its setting, and the agent under study; in some cases, a combination of approaches may be appropriate. The workgroup recognized the need for more research on approaches to the assessment of congenital anomalies to better guide investigators in optimal design of clinical trials that enroll pregnant women. C1 [Rasmussen, Sonja A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Hernandez-Diaz, Sonia] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. [Abdul-Rahman, Omar A.] Univ Mississippi, Med Ctr, University, MS 38677 USA. [Sahin, Leyla] US FDA, Silver Spring, MD USA. [Petrie, Carey R.] EMMES Corp, Rockville, MD USA. [Keppler-Noreuil, Kim M.; Mason, Robin M.; Nesin, Mirjana] NIH, Bethesda, MD 20892 USA. [Frey, Sharon E.] St Louis Univ, Sch Med, St Louis, MO 63103 USA. [Carey, John C.] Univ Utah, Sch Med, Salt Lake City, UT USA. RP Rasmussen, SA (reprint author), CDC, 1600 Clifton Rd,MS A-28, Atlanta, GA 30333 USA. EM skr9@cdc.gov FU NIAID (HHS) [HHSN272200800013C] FX C. R. P.'s work on the article was supported by NIAID contract (HHS contract HHSN272200800013C). NR 40 TC 1 Z9 1 U1 1 U2 12 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 EI 1537-6591 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2014 VL 59 SU 7 BP S428 EP S436 DI 10.1093/cid/ciu738 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AU9LB UT WOS:000345913100005 PM 25425721 ER PT J AU Navarro-Colorado, C Mahamud, A Burton, A Haskew, C Maina, GK Wagacha, JB Ahmed, JA Shetty, S Cookson, S Goodson, JL Schilperoord, M Spiegel, P AF Navarro-Colorado, Carlos Mahamud, Abdirahman Burton, Ann Haskew, Christopher Maina, Gidraf K. Wagacha, John B. Ahmed, Jamal A. Shetty, Sharmila Cookson, Susan Goodson, James L. Schilperoord, Marian Spiegel, Paul TI Measles Outbreak Response Among Adolescent and Adult Somali Refugees Displaced by Famine in Kenya and Ethiopia, 2011 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE measles; mortality; adults; vaccination; refugees; acute malnutrition; famine; population displacement ID MORTALITY; CAMPS AB The refugee complexes of Dadaab, Kenya, and Dollo-Ado, Ethiopia, experienced measles outbreaks during June-November 2011, following a large influx of refugees from Somalia. Line-lists from health facilities were used to describe the outbreak in terms of age, sex, vaccination status, arrival date, attack rates (ARs), and case fatality ratios (CFRs) for each camp. Vaccination data and coverage surveys were reviewed. In Dadaab, 1370 measles cases and 32 deaths (CFR, 2.3%) were reported. A total of 821 cases (60.1%) were aged a parts per thousand yen15 years, 906 (82.1%) arrived to the camps in 2011, and 1027 (79.6%) were unvaccinated. Camp-specific ARs ranged from 212 to 506 cases per 100 000 people. In Dollo-Ado, 407 cases and 23 deaths (CFR, 5.7%) were reported. Adults aged a parts per thousand yen15 years represented 178 cases (43.7%) and 6 deaths (26.0%). Camp-specific ARs ranged from 21 to 1100 cases per 100 000 people. Immunization activities that were part of the outbreak responses initially targeted children aged 6 months to 14 years and were later expanded to include individuals up to 30 years of age. The target age group for outbreak response-associated immunization activities at the start of the outbreaks was inconsistent with the numbers of cases among unvaccinated adolescents and adults in the new population. In displacement of populations from areas affected by measles outbreaks, health authorities should consider vaccinating adults in routine and outbreak response activities. C1 [Navarro-Colorado, Carlos; Mahamud, Abdirahman; Shetty, Sharmila; Cookson, Susan; Goodson, James L.] Ctr Dis Control & Prevent CDC, Atlanta, GA USA. [Burton, Ann; Wagacha, John B.] UNHCR, Nairobi, Kenya. [Haskew, Christopher; Schilperoord, Marian; Spiegel, Paul] UNHCR, Geneva, Switzerland. [Maina, Gidraf K.] UNHCR, Addis Ababa, Ethiopia. [Ahmed, Jamal A.] CDC, Nairobi, Kenya. RP Navarro-Colorado, C (reprint author), Ctr Dis Control & Prevent, Emergency Response & Recovery Branch, Div Global Hlth Protect, Ctr Global Hlth, 1600 Clifton Rd NE,Mailstop F-60, Atlanta, GA 30333 USA. EM cnavarrocolorado@cdc.gov OI Navarro Colorado, Carlos/0000-0002-2185-0157 FU Centers for Disease Control and Prevention FX This work was supported by the Centers for Disease Control and Prevention and the United Nations High Commissioner for Refugees as part of their routine activity. NR 19 TC 1 Z9 1 U1 0 U2 28 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2014 VL 210 IS 12 BP 1863 EP 1870 DI 10.1093/infdis/jiu395 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA AU7HK UT WOS:000345771200003 PM 25117754 ER PT J AU Colapinto, CK Tremblay, MS Aufreiter, S Bushnik, T Pfeiffer, CM O'Connor, DL AF Colapinto, Cynthia K. Tremblay, Mark S. Aufreiter, Susanne Bushnik, Tracey Pfeiffer, Christine M. O'Connor, Deborah L. TI The direction of the difference between Canadian and American erythrocyte folate concentrations is dependent on the assay method employed: a comparison of the Canadian Health Measures Survey and National Health and Nutrition Examination Survey SO BRITISH JOURNAL OF NUTRITION LA English DT Article DE Folic acid; Erythrocyte folate; Folate status; National Health and Nutrition Examination Survey; Canadian Health Measures Survey ID NEURAL-TUBE DEFECTS; FOLIC-ACID FORTIFICATION; WHOLE-BLOOD FOLATE; MICROBIOLOGIC ASSAY; NHANES 1988-2010; RBC FOLATE; SERUM; POPULATION; VITAMIN; PREVALENCE AB Fortification of select grain products with folic acid and periconceptional supplementation recommendations in Canada and the USA have improved folate status, and have been associated with a reduced risk of neural tube defects. In the present study, we aimed to conduct a comparison of erythrocyte folate concentrations from the 2007-9 Canadian Health Measures Survey (CHMS) and the 2007-8 US National Health and Nutrition Examination Survey (NHANES). Erythrocyte folate concentration was assessed in participants aged 6-79 years (CHMS, n 5248; NHANES, n 7070). To account for different folate assays employed -Immulite 2000 immunoassay (CHMS) and microbiological assay (NHANES) - a conversion equation was generated (n 152 adults) to adjust the CHMS data. t Tests were used to examine country differences. Median Canadian erythrocyte folate concentrations (method-adjusted) were lower than those of Americans (988 and 1100 nmol/l, respectively), but unadjusted median Canadian erythrocyte folate concentrations were higher (1250 nmol/l). The upper 95% CI boundary of the method-adjusted Canadian erythrocyte folate distribution overlapped that of the American erythrocyte folate concentrations, while the lower 95% CI boundary of the method-adjusted Canadian erythrocyte folate data was below the American distribution. In summary, the fact that erythrocyte folate concentrations were either higher or lower in Canadians compared with Americans, depending on whether an adjustment was made to account for assay differences, suggests that caution must be exercised in evaluating erythrocyte folate data from different countries because analytical methods are not readily comparable. Furthermore, we cannot unequivocally conclude that there are true differences in erythrocyte folate concentrations between the Canadian and American populations in the post-fortification era. C1 [Colapinto, Cynthia K.; Tremblay, Mark S.] Childrens Hosp Eastern Ontario, Res Inst, Healthy Act Living & Obes Res Grp, Ottawa, ON K1H 8L1, Canada. [Colapinto, Cynthia K.] Univ Ottawa, Inst Populat Hlth, Ottawa, ON, Canada. [Tremblay, Mark S.] Univ Ottawa, Dept Pediat, Ottawa, ON K1N 6N5, Canada. [Aufreiter, Susanne; O'Connor, Deborah L.] Hosp Sick Children, Physiol & Expt Med Program, Toronto, ON M5G 1X8, Canada. [Bushnik, Tracey] STAT Canada, Hlth Anal Div, Ottawa, ON, Canada. [Pfeiffer, Christine M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [O'Connor, Deborah L.] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada. RP O'Connor, DL (reprint author), Hosp Sick Children, Physiol & Expt Med Program, 555 Univ Ave, Toronto, ON M5G 1X8, Canada. EM deborah_l.oconnor@sickkids.ca FU Canadian Institutes of Health Research (CIHR) Health Professionals Fellowship in the Area of Public Health [180375]; CIHR Operating Grant [218776] FX The authors thank the Health Analysis Division at Statistics Canada, in particular Julie Bernier for her support during the generation of the conversion equation, and the Physical Health Measures Division at Statistics Canada for preparing and granting special access to data. The authors also thank Steve Brooks and Penny Jee for the CHMS laboratory blood analysis in the conversion equation sub-study and Trevor Stewart for his review and feedback on the manuscript. The authors thank all participants in the conversion equation sub-study, the CHMS and the NHANES. This work was supported by Canadian Institutes of Health Research (CIHR) Health Professionals Fellowship in the Area of Public Health (funding reference no. 180375) to C.K.C. and a CIHR Operating Grant (funding reference no. 218776) to M.S.T., D.L.O. and C.K.C. NR 40 TC 7 Z9 7 U1 0 U2 3 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0007-1145 EI 1475-2662 J9 BRIT J NUTR JI Br. J. Nutr. PD DEC 14 PY 2014 VL 112 IS 11 BP 1873 EP 1881 DI 10.1017/S0007114514002906 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA AX7NH UT WOS:000347102000013 PM 25296277 ER PT J AU Choudhary, E Vaidyanathan, A AF Choudhary, Ekta Vaidyanathan, Ambarish TI Heat Stress Illness Hospitalizations - Environmental Public Health Tracking Program, 20 States, 2001-2010 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID EMERGENCY-DEPARTMENT VISITS; CLIMATE VARIABILITY; NORTH-CAROLINA; UNITED-STATES; RISK-FACTORS; TEMPERATURE; IMPACTS; MORBIDITY; WAVES AB Problem/Condition: Heat stress illness (HSI), also known as heat-related illness, comprises mild heat edema, heat syncope, heat cramps, heat exhaustion (the most common type of HSI), and heat stroke (the most severe form). CDC's Environmental Public Health Tracking Program receives annual hospitalization discharge data from 23 states that are used to assess and monitor trends of HSI hospitalization over time. Reporting Period: May September, 2001-2010. Description of System: The Environmental Public Health Tracking Program is a comprehensive surveillance system implemented in 25 states and one city health department. The core of the system is the Tracking Network, which collects data on environmental hazards, health effects, exposures, and population. The Tracking Network provides nationally consistent environmental and health outcome data that enable federal, state, and local public health agencies to assess trends, explore associations, and generate hypotheses using these data. For HSI surveillance, the Tracking Network uses state-based hospital discharge data. Results: During 2001-2010, approximately 28,000 HSI hospitalizations occurred in 20 states participating in the Tracking Program. Data from three states were not included in this report because of missing data for years. Two states joined the Tracking Program after the study period and also are not included in this report. The majority of HSI hospitalizations occurred among males and persons aged 65 years. The highest rates of hospitalizations were in the Midwest and the South. During this period, an overall 2%-5% increase in the rate of HSI hospitalizations occurred in all 20 states compared with the 2001 rate. The correlation between the average number of HSI hospitalizations and the average monthly maximum temperature/heat index was statistically significant (at p<0.0001) in all 20 states. Interpretation: Consistent with previous studies, age and sex were identified as major risk factors for HSI hospitalizations. Certain Tracking states that experienced high temperatures during summer months showed an increase in rate of HSI hospitalizations over the 10-year study period. Public Health Action: HSIs are preventable and an important focus of public health interventions at state and local health departments. Federal, state, and local public health agencies can use data on HSI hospitalizations for surveillance purposes to estimate trends over time and to design targeted intervention to reduce heat stress morbidity among at-risk populations. C1 [Choudhary, Ekta; Vaidyanathan, Ambarish] Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Atlanta, GA 30333 USA. RP Choudhary, E (reprint author), Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Atlanta, GA 30333 USA. EM echoudhary@cdc.gov NR 25 TC 0 Z9 0 U1 1 U2 3 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 12 PY 2014 VL 63 IS 13 SU S BP 1 EP 10 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY7MS UT WOS:000347744800001 ER PT J AU Choudhary, E Vaidyanathan, A AF Choudhary, Ekta Vaidyanathan, Ambarish TI Heat Stress Illness Hospitalizations - Environmental Public Health Tracking Program, 20 States, 2001-2010 SO MMWR SURVEILLANCE SUMMARIES LA English DT Article ID EMERGENCY-DEPARTMENT VISITS; CLIMATE VARIABILITY; NORTH-CAROLINA; UNITED-STATES; RISK-FACTORS; TEMPERATURE; IMPACTS; MORBIDITY; WAVES AB Problem/Condition: Heat stress illness (HSI), also known as heat-related illness, comprises mild heat edema, heat syncope, heat cramps, heat exhaustion (the most common type of HSI), and heat stroke (the most severe form). CDC's Environmental Public Health Tracking Program receives annual hospitalization discharge data from 23 states that are used to assess and monitor trends of HSI hospitalization over time. Reporting Period: May-September, 2001-2010. Description of System: The Environmental Public Health Tracking Program is a comprehensive surveillance system implemented in 25 states and one city health department. The core of the system is the Tracking Network, which collects data on environmental hazards, health effects, exposures, and population. The Tracking Network provides nationally consistent environmental and health outcome data that enable federal, state, and local public health agencies to assess trends, explore associations, and generate hypotheses using these data. For HSI surveillance, the Tracking Network uses state-based hospital discharge data. Results: During 2001-2010, approximately 28,000 HSI hospitalizations occurred in 20 states participating in the Tracking Program. Data from three states were not included in this report because of missing data for = 3 years. Two states joined the Tracking Program after the study period and also are not included in this report. The majority of HSI hospitalizations occurred among males and persons aged = 65 years. The highest rates of hospitalizations were in the Midwest and the South. During this period, an overall 2%-5% increase in the rate of HSI hospitalizations occurred in all 20 states compared with the 2001 rate. The correlation between the average number of HSI hospitalizations and the average monthly maximum temperature/heat index was statistically significant (at p< 0.0001) in all 20 states. Interpretation: Consistent with previous studies, age and sex were identified as major risk factors for HSI hospitalizations. Certain Tracking states that experienced high temperatures during summer months showed an increase in rate of HSI hospitalizations over the 10-year study period. Public Health Action: HSIs are preventable and an important focus of public health interventions at state and local health departments. Federal, state, and local public health agencies can use data on HSI hospitalizations for surveillance purposes to estimate trends over time and to design targeted intervention to reduce heat stress morbidity among at-risk populations. C1 [Choudhary, Ekta; Vaidyanathan, Ambarish] Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Atlanta, GA 30341 USA. RP Choudhary, E (reprint author), Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Atlanta, GA 30341 USA. EM echoudhary@cdc.gov NR 25 TC 2 Z9 2 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-8636 J9 MMWR SURVEILL SUMM JI MMWR Surv. Summ. PD DEC 12 PY 2014 VL 63 IS 13 BP 1 EP 14 PG 14 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY5SE UT WOS:000347631100001 ER PT J AU Reed, C Kim, IK Singleton, JA Chaves, SS Flannery, B Finelli, L Fry, A Burns, E Gargiullo, P Jernigan, D Cox, N Bresee, J AF Reed, Carrie Kim, Inkyu Kevin Singleton, James A. Chaves, Sandra S. Flannery, Brendan Finelli, Lyn Fry, Alicia Burns, Erin Gargiullo, Paul Jernigan, Daniel Cox, Nancy Bresee, Joseph TI Estimated Influenza Illnesses and Hospitalizations Averted by Vaccination - United States, 2013-14 Influenza Season SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Reed, Carrie; Kim, Inkyu Kevin; Chaves, Sandra S.; Flannery, Brendan; Finelli, Lyn; Fry, Alicia; Burns, Erin; Gargiullo, Paul; Jernigan, Daniel; Cox, Nancy; Bresee, Joseph] CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Singleton, James A.] CDC, Immunizat Serv Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Reed, C (reprint author), CDC, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. EM creed1@cdc.gov NR 10 TC 27 Z9 27 U1 0 U2 5 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 12 PY 2014 VL 63 IS 49 BP 1151 EP 1154 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX3CT UT WOS:000346818900002 PM 25503917 ER PT J AU Ojodu, J Hulihan, MM Pope, SN Grant, AM AF Ojodu, Jelili Hulihan, Mary M. Pope, Shammara N. Grant, Althea M. TI Incidence of Sickle Cell Trait - United States, 2010 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Ojodu, Jelili] CDC, Assoc Publ Hlth Labs, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Hulihan, Mary M.; Pope, Shammara N.; Grant, Althea M.] CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. RP Hulihan, MM (reprint author), CDC, Div Blood Disorders, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. EM ibx5@cdc.gov NR 8 TC 10 Z9 10 U1 0 U2 5 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 12 PY 2014 VL 63 IS 49 BP 1155 EP 1158 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX3CT UT WOS:000346818900003 PM 25503918 ER PT J AU Murray, J Agocs, M Serhan, F Singh, S Deloria-Knoll, M O'Brien, K Mwenda, JM Mihigo, R Oliveira, L Teleb, N Ahmed, H Wasley, A Videbaek, D Wijesinghe, P Thapa, AB Fox, K Paladin, FJ Hajjeh, R Schwartz, S Van Beneden, C Hyde, T Broome, C Cherian, T AF Murray, Jillian Agocs, Mary Serhan, Fatima Singh, Simarjit Deloria-Knoll, Maria O'Brien, Katherine Mwenda, Jason M. Mihigo, Richard Oliveira, Lucia Teleb, Nadia Ahmed, Hinda Wasley, Annemarie Videbaek, Dovile Wijesinghe, Pushpa Thapa, Arun Bhadra Fox, Kimberly Paladin, Fern Julia Hajjeh, Rana Schwartz, Stephanie Van Beneden, Chris Hyde, Terri Broome, Claire Cherian, Thomas TI Global Invasive Bacterial Vaccine-Preventable Diseases Surveillance-2008-2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Murray, Jillian; Agocs, Mary; Serhan, Fatima; Singh, Simarjit; Cherian, Thomas] World Hlth Org WHO, Dept Immunizat Vaccines & Biol, Geneva, Switzerland. [Murray, Jillian; Deloria-Knoll, Maria; O'Brien, Katherine] Johns Hopkins Univ, IVAC, Baltimore, MD 21218 USA. [Mwenda, Jason M.; Mihigo, Richard] WHO Reg Off Africa, Brazzaville, Congo. [Oliveira, Lucia] WHO Reg Off Amer, Washington, DC USA. [Teleb, Nadia; Ahmed, Hinda] WHO Reg Off Eastern Mediterranean, Cairo, Egypt. [Wasley, Annemarie; Videbaek, Dovile] WHO Reg Off Europe, Copenhagen, Denmark. [Wijesinghe, Pushpa; Thapa, Arun Bhadra] WHO Reg Off South East Asia, New Delhi, India. [Fox, Kimberly; Paladin, Fern Julia] WHO Reg Off Western Pacific, Manila, Philippines. [Hajjeh, Rana; Schwartz, Stephanie; Van Beneden, Chris] CDC, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Hyde, Terri] CDC, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. [Broome, Claire] Emory Univ, Atlanta, GA 30322 USA. RP Agocs, M (reprint author), World Hlth Org WHO, Dept Immunizat Vaccines & Biol, Geneva, Switzerland. EM agoesm@who.int NR 4 TC 11 Z9 11 U1 0 U2 1 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 12 PY 2014 VL 63 IS 49 BP 1159 EP 1162 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX3CT UT WOS:000346818900004 PM 25503919 ER PT J AU Brown, CM Aranas, AE Benenson, GA Brunette, G Cetron, M Chen, TH Cohen, NJ Diaz, P Haber, Y Hale, CR Holton, K Kohl, K Lee, AW Palumbo, GJ Pearson, K Phares, CR Alvarado-Ramy, F Roohi, S Rotz, LD Tappero, J Washburn, FM Watkins, J Pesik, N AF Brown, Clive M. Aranas, Aaron E. Benenson, Gabrielle A. Brunette, Gary Cetron, Marty Chen, Tai-Ho Cohen, Nicole J. Diaz, Pam Haber, Yonat Hale, Christa R. Holton, Kelly Kohl, Katrin Lee, Amanda W. Palumbo, Gabriel J. Pearson, Kate Phares, Christina R. Alvarado-Ramy, Francisco Roohi, Shah Rotz, Lisa D. Tappero, Jordan Washburn, Faith M. Watkins, James Pesik, Nicki TI Airport Exit and Entry Screening for Ebola - August-November 10, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID UNITED-STATES C1 [Brown, Clive M.; Benenson, Gabrielle A.; Brunette, Gary; Cetron, Marty; Chen, Tai-Ho; Cohen, Nicole J.; Haber, Yonat; Hale, Christa R.; Holton, Kelly; Kohl, Katrin; Lee, Amanda W.; Palumbo, Gabriel J.; Pearson, Kate; Phares, Christina R.; Alvarado-Ramy, Francisco; Roohi, Shah; Rotz, Lisa D.; Washburn, Faith M.; Watkins, James; Pesik, Nicki] CDC, Div Global Migrat & Quarantine, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Diaz, Pam] CDC, Ctr Surveillance, Epidemiol Serv, Atlanta, GA 30333 USA. [Diaz, Pam] CDC, Ctr Surveillance, Lab Serv, Atlanta, GA 30333 USA. [Tappero, Jordan] CDC, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Brown, CM (reprint author), CDC, Div Global Migrat & Quarantine, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM cmb8@cdc.gov NR 7 TC 15 Z9 15 U1 0 U2 7 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 12 PY 2014 VL 63 IS 49 BP 1163 EP 1167 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX3CT UT WOS:000346818900005 PM 25503920 ER PT J AU Kilmarx, PH Clarke, KR Dietz, PM Hamel, MJ Husain, F McFadden, JD Park, BJ Sugerman, DE Bresee, JS Mermin, J McAuley, J Jambai, A AF Kilmarx, Peter H. Clarke, Kevin R. Dietz, Patricia M. Hamel, Mary J. Husain, Farah McFadden, Jevon D. Park, Benjamin J. Sugerman, David E. Bresee, Joseph S. Mermin, Jonathan McAuley, James Jambai, Amara TI Ebola Virus Disease in Health Care Workers - Sierra Leone, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Kilmarx, Peter H.; Clarke, Kevin R.; Dietz, Patricia M.; Husain, Farah; McFadden, Jevon D.; Park, Benjamin J.; Sugerman, David E.; Bresee, Joseph S.; Mermin, Jonathan; McAuley, James] CDC, Sierra Leone Ebola Response Team, Atlanta, GA 30333 USA. [Kilmarx, Peter H.; Clarke, Kevin R.; McAuley, James] CDC, Div Global HIV AIDS, Ctr Global Hlth, Atlanta, GA 30333 USA. [Kilmarx, Peter H.] CDC Zimbabwe, Harare, Zimbabwe. [Dietz, Patricia M.; Mermin, Jonathan] CDC, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Hamel, Mary J.] CDC, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. [Husain, Farah; Sugerman, David E.] CDC, Div Global Hlth Protect, Ctr Global Hlth, Atlanta, GA 30333 USA. [McFadden, Jevon D.] CDC, Div State & Local Readiness, Off Publ Hlth Preparedness & Response, Atlanta, GA 30333 USA. [Park, Benjamin J.] CDC, Div Healthcare Qual Promot, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Bresee, Joseph S.] CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [McAuley, James] CDC Zambia, Lusaka, Zambia. [Jambai, Amara] Minist Hlth & Sanitat, Freetown, Sierra Leone. RP Kilmarx, PH (reprint author), CDC, Sierra Leone Ebola Response Team, Atlanta, GA 30333 USA. EM pbk4@cdc.gov NR 5 TC 45 Z9 47 U1 0 U2 8 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 12 PY 2014 VL 63 IS 49 BP 1168 EP 1171 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX3CT UT WOS:000346818900006 PM 25503921 ER PT J AU Pathmanathan, I O'Connor, KA Adams, ML Rao, CY Kilmarx, PH Park, BJ Mermin, J Kargbo, B Wurie, AH Clarke, KR AF Pathmanathan, Ishani O'Connor, Katherine A. Adams, Monica L. Rao, Carol Y. Kilmarx, Peter H. Park, Benjamin J. Mermin, Jonathan Kargbo, Brima Wurie, Alie H. Clarke, Kevin R. TI Rapid Assessment of Ebola Infection Prevention and Control Needs - Six Districts, Sierra Leone, October 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Pathmanathan, Ishani; Adams, Monica L.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Pathmanathan, Ishani; O'Connor, Katherine A.; Adams, Monica L.; Rao, Carol Y.; Kilmarx, Peter H.; Park, Benjamin J.; Mermin, Jonathan; Clarke, Kevin R.] CDC Sierra Leone Ebola Response Team, Freetown, Sierra Leone. [Kargbo, Brima; Wurie, Alie H.] Sierra Leone Minist Hlth & Sanitat, Freetown, Sierra Leone. RP Pathmanathan, I (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM ydi6@cdc.gov NR 2 TC 16 Z9 17 U1 1 U2 24 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 12 PY 2014 VL 63 IS 49 BP 1172 EP 1174 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX3CT UT WOS:000346818900007 PM 25503922 ER PT J AU Karwowski, MP Meites, E Fullerton, KE Stroher, U Lowe, L Rayfield, M Blau, DM Knust, B Gindler, J Van Beneden, C Bialek, SR Mead, P Oster, AM AF Karwowski, Mateusz P. Meites, Elissa Fullerton, Kathleen E. Stroeher, Ute Lowe, Luis Rayfield, Mark Blau, Dianna M. Knust, Barbara Gindler, Jacqueline Van Beneden, Chris Bialek, Stephanie R. Mead, Paul Oster, Alexandra M. TI Clinical Inquiries Regarding Ebola Virus Disease Received by CDC - United States, July 9-November 15, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article C1 [Karwowski, Mateusz P.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Karwowski, Mateusz P.; Meites, Elissa; Fullerton, Kathleen E.; Stroeher, Ute; Lowe, Luis; Rayfield, Mark; Blau, Dianna M.; Knust, Barbara; Gindler, Jacqueline; Van Beneden, Chris; Bialek, Stephanie R.; Mead, Paul; Oster, Alexandra M.] CDC, Epidemiol Lab Task Force, Ebola Response Team 2014, Atlanta, GA 30333 USA. [Karwowski, Mateusz P.] CDC, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30333 USA. [Meites, Elissa] CDC, Div STD Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Gindler, Jacqueline] CDC, Div HIV AIDS Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Atlanta, GA 30333 USA. [Fullerton, Kathleen E.] CDC, Div Hlth Informat & Surveillance, Ctr Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA. [Stroeher, Ute; Blau, Dianna M.; Knust, Barbara] CDC, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Lowe, Luis] CDC, Div Preparedness & Emerging Infect, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Mead, Paul] CDC, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Rayfield, Mark] CDC, Div Global Dis Detect & Emergency Response, Ctr Global Hlth, Atlanta, GA 30333 USA. [Gindler, Jacqueline] CDC, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. [Van Beneden, Chris; Oster, Alexandra M.] CDC, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Bialek, Stephanie R.] CDC, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. RP Karwowski, MP (reprint author), CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. EM ydh4@cdc.gov OI Meites, Elissa/0000-0002-0077-2591 NR 11 TC 12 Z9 12 U1 0 U2 11 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 12 PY 2014 VL 63 IS 49 BP 1175 EP 1179 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX3CT UT WOS:000346818900008 PM 25503923 ER PT J AU Rajan, D McCracken, CE Kopleman, HB Kyu, SY Lee, FEH Lu, XY Anderson, LJ AF Rajan, Devi McCracken, Courtney E. Kopleman, Hannah B. Kyu, Shuya Y. Lee, F. Eun-Hyung Lu, Xiaoyan Anderson, Larry J. TI Human Rhinovirus Induced Cytokine/Chemokine Responses in Human Airway Epithelial and Immune Cells SO PLOS ONE LA English DT Article ID RESPIRATORY-TRACT INFECTIONS; BLOOD MONONUCLEAR-CELLS; ASTHMA EXACERBATIONS; MONOCYTIC CELLS; CHILDREN; EXPRESSION; RECEPTOR; RELEASE; IMMUNIZATION; REPLICATION AB Infections with human rhinovirus (HRV) are commonly associated with acute upper and lower respiratory tract disease and asthma exacerbations. The role that HRVs play in these diseases suggests it is important to understand host-specific or virus-specific factors that contribute to pathogenesis. Since species A HRVs are often associated with more serious HRV disease than species B HRVs, differences in immune responses they induce should inform disease pathogenesis. To identify species differences in induced responses, we evaluated 3 species A viruses, HRV 25, 31 and 36 and 3 species B viruses, HRV 4, 35 and 48 by exposing human PBMCs to HRV infected Calu-3 cells. To evaluate the potential effect of memory induced by previous HRV infection on study responses, we tested cord blood mononuclear cells that should be HRV naive. There were HRV-associated increases (significant increase compared to mock-infected cells) for one or more HRVs for IP-10 and IL-15 that was unaffected by addition of PBMCs, for MIP-1 alpha, MIP-1 beta, IFN-alpha, and HGF only with addition of PBMCs, and for ENA-78 only without addition of PBMCs. All three species B HRVs induced higher levels, compared to A HRVs, of MIP-1 alpha and MIP-1 beta with PBMCs and ENA-78 without PBMCs. In contrast, addition of CBMCs had less effect and did not induce MIP-1 alpha, MIP-1 beta, or IFN-alpha nor block ENA-78 production. Addition of CBMCs did, however, increase IP-10 levels for HRV 35 and HRV 36 infection. The presence of an effect with PBMCs and no effect with CBMCs for some responses suggest differences between the two types of cells possibly because of the presence of HRV memory responses in PBMCs and not CBMCs or limited response capacity for the immature CBMCs relative to PBMCs. Thus, our results indicate that different HRV strains can induce different patterns of cytokines and chemokines; some of these differences may be due to differences in memory responses induced by past HRV infections, and other differences related to virus factors that can inform disease pathogenesis. C1 [Rajan, Devi; McCracken, Courtney E.; Kopleman, Hannah B.; Anderson, Larry J.] Emory Childrens Ctr, Dept Pediat, Atlanta, GA 30322 USA. [Kyu, Shuya Y.; Lee, F. Eun-Hyung] Emory Univ, Div Pulm Allergy & Crit Care Med, Atlanta, GA 30322 USA. [Lu, Xiaoyan] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. RP Anderson, LJ (reprint author), Emory Childrens Ctr, Dept Pediat, Atlanta, GA 30322 USA. EM larry.anderson@emory.edu FU NIH - Children's Healthcare of Atlanta [1U19AI095227]; Immunology Core of Emory Children's Pediatric Research Center FX This study was supported by NIH 1U19AI095227 grant, funding from Children's Healthcare of Atlanta, and the Immunology Core of Emory Children's Pediatric Research Center. NR 44 TC 3 Z9 3 U1 2 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 12 PY 2014 VL 9 IS 12 AR e114322 DI 10.1371/journal.pone.0114322 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AW6JI UT WOS:000346375400028 PM 25500821 ER PT J AU Blackard, JT Ma, G Welge, JA King, CC Taylor, LE Mayer, KH Klein, RS Celentano, DD Sobel, JD Jamieson, DJ Gardner, L AF Blackard, Jason T. Ma, Gang Welge, Jeffrey A. King, Caroline C. Taylor, Lynn E. Mayer, Kenneth H. Klein, Robert S. Celentano, David D. Sobel, Jack D. Jamieson, Denise J. Gardner, Lytt TI GB Virus C (GBV-C) Infection in Hepatitis C Virus (HCV) Seropositive Women with or at Risk for HIV Infection SO PLOS ONE LA English DT Article ID C/HEPATITIS-G VIRUS; MOTHER-TO-INFANT; ACTIVE ANTIRETROVIRAL THERAPY; HIV-1-INFECTED PATIENTS; DISEASE PROGRESSION; SEXUAL TRANSMISSION; LIVER-DISEASE; US WOMEN; COINFECTION; PREVALENCE AB Background: GB virus C (GBV-C) may have a beneficial impact on HIV disease progression; however, the epidemiologic characteristics of this virus are not well characterized. Behavioral factors and gender may lead to differential rates of GBV-C infection; yet, studies have rarely addressed GBV-C infections in women or racial/ethnic minorities. Therefore, we evaluated GBV-C RNA prevalence and genotype distribution in a large prospective study of high-risk women in the US. Results: 438 hepatitis C virus (HCV) seropositive women, including 306 HIV-infected and 132 HIV-uninfected women, from the HIV Epidemiologic Research Study were evaluated for GBV-C RNA. 347 (79.2%) women were GBV-C RNA negative, while 91 (20.8%) were GBV-C RNA positive. GBV-C positive women were younger than GBV-C negative women. Among 306 HIV-infected women, 70 (22.9%) women were HIV/GBV-C co-infected. Among HIV-infected women, the only significant difference between GBV-negative and GBV-positive women was age (mean 38.4 vs. 35.1 years; p<0.001). Median baseline CD4 cell counts and plasma HIV RNA levels were similar. The GBV-C genotypes were 1 (n=31; 44.3%), 2 (n=36; 51.4%), and 3 (n=3; 4.3%). The distribution of GBV-C genotypes in co-infected women differed significantly by race/ethnicity. However, median CD4 cell counts and log(10) HIV RNA levels did not differ by GBV-C genotype. GBV-C incidence was 2.7% over a median follow-up of 2.9 (IQR: 1.5, 4.9) years, while GBV-C clearance was 35.7% over a median follow-up of 2.44 (1.4, 3.5) years. 4 women switched genotypes. Conclusions: Age, injection drug use, a history of sex for money or drugs, and number of recent male sex partners were associated with GBV-C infection among all women in this analysis. However, CD4 cell count and HIV viral load of HIV/HCV/GBV-C co-infected women were not different although race was associated with GBV-C genotype. C1 [Blackard, Jason T.; Ma, Gang] Univ Cincinnati, Coll Med, Div Digest Dis, Cincinnati, OH 45220 USA. [Welge, Jeffrey A.] Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH 45221 USA. [Welge, Jeffrey A.] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA. [King, Caroline C.; Jamieson, Denise J.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Taylor, Lynn E.] Brown Univ, Miriam Hosp, Providence, RI USA. [Taylor, Lynn E.] Brown Univ, Dept Med, Providence, RI 02912 USA. [Mayer, Kenneth H.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Mayer, Kenneth H.] Fenway Inst, Boston, MA USA. [Klein, Robert S.] Mt Sinai Sch Med, Mt Sinai St Lukes Hosp, Div Infect Dis, New York, NY USA. [Klein, Robert S.] Mt Sinai Sch Med, Mt Sinai Roosevelt Hosp, New York, NY USA. [Celentano, David D.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Sobel, Jack D.] Wayne State Univ, Sch Med, Div Infect Dis, Detroit, MI USA. [Gardner, Lytt] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. RP Blackard, JT (reprint author), Univ Cincinnati, Coll Med, Div Digest Dis, Cincinnati, OH 45220 USA. EM jason.blackard@uc.edu FU National Institute on Allergy and Infectious Diseases [AI081564] FX This work was supported by the National Institute on Allergy and Infectious Diseases (award AI081564 to JTB). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 47 TC 1 Z9 1 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 10 PY 2014 VL 9 IS 12 AR e114467 DI 10.1371/journal.pone.0114467 PG 14 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AW9YP UT WOS:000346611400047 PM 25493916 ER PT J AU Factor-Litvak, P Insel, B Calafat, AM Liu, XH Perera, F Rauh, VA Whyatt, RM AF Factor-Litvak, Pam Insel, Beverly Calafat, Antonia M. Liu, Xinhua Perera, Frederica Rauh, Virginia A. Whyatt, Robin M. TI Persistent Associations between Maternal Prenatal Exposure to Phthalates on Child IQ at Age 7 Years SO PLOS ONE LA English DT Article ID NUTRITION EXAMINATION SURVEY; BISPHENOL-A; DI-(2-ETHYLHEXYL) PHTHALATE; TEMPORAL VARIABILITY; LACTATIONAL EXPOSURE; NATIONAL-HEALTH; MALE RATS; IN-VITRO; METABOLITES; INTELLIGENCE AB Background: Prior research reports inverse associations between maternal prenatal urinary phthalate metabolite concentrations and mental and motor development in preschoolers. No study evaluated whether these associations persist into school age. Methods: In a follow up of 328 inner-city mothers and their children, we measured prenatal urinary metabolites of di-n-butyl phthalate (DnBP), butylbenzyl phthalate (BBzP), di-isobutyl phthalate (DiBP), di-2-ethylhexyl phthalate and diethyl phthalate in late pregnancy. The Wechsler Intelligence Scale for Children, 4th edition was administered at child age 7 years and evaluates four areas of cognitive function associated with overall intelligence quotient (IQ). Results: Child full-scale IQ was inversely associated with prenatal urinary metabolite concentrations of DnBP and DiBP: b=-22.69 (95% confidence interval [CI] = -4.33, -1.05) and b= -2.69 (95% CI= -4.22, -1.16) per log unit increase. Among children of mothers with the highest versus lowest quartile DnBP and DiBP metabolite concentrations, IQ was 6.7 (95% CI= 1.9, 11.4) and 7.6 (95% CI= 3.2, 12.1) points lower, respectively. Associations were unchanged after control for cognition at age 3 years. Significant inverse associations were also seen between maternal prenatal metabolite concentrations of DnBP and DiBP and child processing speed, perceptual reasoning and working memory; DiBP and child verbal comprehension; and BBzP and child perceptual reasoning. Conclusion: Maternal prenatal urinary metabolite concentrations measured in late pregnancy of DnBP and DiBP are associated with deficits in children's intellectual development at age 7 years. Because phthalate exposures are ubiquitous and concentrations seen here within the range previously observed among general populations, results are of public health significance. C1 [Factor-Litvak, Pam; Insel, Beverly] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10027 USA. [Calafat, Antonia M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Liu, Xinhua] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY USA. [Perera, Frederica; Whyatt, Robin M.] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, Columbia Ctr Childrens Environm Hlth, New York, NY USA. [Rauh, Virginia A.] Columbia Univ, Mailman Sch Publ Hlth, Heilbrunn Dept Populat & Family Hlth, New York, NY USA. RP Factor-Litvak, P (reprint author), Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10027 USA. EM prf1@columbia.edu FU National Institute of Environmental Health Sciences (NIEHS) [R01ES013543, R01ES014393, R01ES08977]; NIEHS/United States Environmental Protection Agency [P50 ES09600/RD 83214101] FX National Institute of Environmental Health Sciences (NIEHS) grants R01ES013543, R01ES014393, and R01ES08977 and by NIEHS/United States Environmental Protection Agency grant P50 ES09600/RD 83214101. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. NR 44 TC 15 Z9 15 U1 4 U2 13 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 10 PY 2014 VL 9 IS 12 AR e114003 DI 10.1371/journal.pone.0114003 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AW9YP UT WOS:000346611400026 PM 25493564 ER PT J AU Shahrin, L Leung, DT Matin, N Pervez, MM Azim, T Bardhan, PK Heffelfinger, JD Chisti, MJ AF Shahrin, Lubaba Leung, Daniel T. Matin, Nashaba Pervez, Mohammed Moshtaq Azim, Tasnim Bardhan, Pradip Kumar Heffelfinger, James D. Chisti, Mohammod Jobayer TI Characteristics and Predictors of Death among Hospitalized HIV-Infected Patients in a Low HIV Prevalence Country: Bangladesh SO PLOS ONE LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; RISK BEHAVIOR; MORTALITY; AIDS; MIGRATION; ADULTS; HEALTH; HAART; MEN AB Background: Predictors of death in hospitalized HIV-infected patients have not been previously reported in Bangladesh. Objective: The primary aim of this study was to determine predictors of death among hospitalized HIV-infected patients at a large urban hospital in Bangladesh. Methods: A study was conducted in the HIV in-patient unit (Jagori Ward) of icddr,b's Dhaka Hospital. Characteristics of patients who died during hospitalization were compared to those of patients discharged from the ward. Bivariate analysis was performed to determine associations between potential risk factors and death. Multivariable logistic regression was used to identify factors independently associated with death. Results: Of 293 patients admitted to the Jagori Ward, 57 died during hospitalization. Most hospitalized patients (67%) were male and the median age was 35 (interquartile range: 2-65) years. Overall, 153 (52%) patients were diagnosed with HIV within 6 months of hospitalization. The most common presumptive opportunistic infections (OIs) identified were tuberculosis (32%), oesophageal candidiasis (9%), Pneumocystis jirovecii pneumonia (PJP) (8%), and histoplasmosis (7%). On multivariable analysis, independent predictors of mortality were CD4 count <= 200 cells/mm(3) (adjusted odds ratio [aOR]: 16.6, 95% confidence interval [CI]: 3.7-74.4), PJP (aOR: 18.5, 95% CI: 4.68-73.3), oesophageal candidiasis (aOR: 27.5, 95% CI: 5.5-136.9), malignancy (aOR: 15.2, 95% CI: 2.3-99.4), and bacteriuria (aOR: 7.9, 95% CI: 1.2-50.5). Being on antiretroviral therapy prior to hospitalization (aOR: 0.2, 95% CI: 0.06-0.5) was associated with decreased mortality. Conclusion: This study showed that most patients who died during hospitalization on the Jagori Ward had HIV-related illnesses which could have been averted with earlier diagnosis of HIV and proper management of OIs. It is prudent to develop a national HIV screening programme to facilitate early identification of HIV. C1 [Shahrin, Lubaba; Pervez, Mohammed Moshtaq; Bardhan, Pradip Kumar; Chisti, Mohammod Jobayer] Dhaka Hosp, Int Ctr Diarrheal Dis Res, Dhaka, Bangladesh. [Shahrin, Lubaba; Pervez, Mohammed Moshtaq; Chisti, Mohammod Jobayer] Int Ctr Diarrheal Dis Res, CNFS, Dhaka, Bangladesh. [Shahrin, Lubaba; Leung, Daniel T.; Pervez, Mohammed Moshtaq; Azim, Tasnim] Int Ctr Diarrheal Dis Res, Ctr HIV AIDS CHIV, Dhaka, Bangladesh. [Leung, Daniel T.] Int Ctr Diarrheal Dis Res, CVS, Dhaka, Bangladesh. [Matin, Nashaba] Royal London Hosp, Barts Hlth NHS Trust, London E1 1BB, England. [Heffelfinger, James D.] Ctr Dis Control & Prevent CDC, Global Dis Detect Branch, Div Global Hlth Promot, Ctr Global Hlth, Atlanta, GA USA. RP Shahrin, L (reprint author), Dhaka Hosp, Int Ctr Diarrheal Dis Res, Dhaka, Bangladesh. EM lubabashahrin@icddrb.org OI leung, daniel/0000-0001-8401-0801 FU icddr,b FX This research protocol was funded by the icddr,b and its donors who provide unrestricted support to this organization for its infrastructure (such as Dhaka Hospital) and research. Current donors providing unrestricted support include the following: Australian Agency for International Development (AusAID), Government of the People's Republic of Bangladesh, Canadian International Development Agency, Embassy of the Kingdom of Netherlands, Swedish International Development Cooperation Agency, Swiss Agency for Development and Cooperation and Department for International Development, UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 30 TC 5 Z9 5 U1 1 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 8 PY 2014 VL 9 IS 12 AR e113095 DI 10.1371/journal.pone.0113095 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AX4MX UT WOS:000346907600014 PM 25485634 ER PT J AU Kassim, AA Payne, AB Rodeghier, M Macklin, EA Strunk, RC DeBaun, MR AF Kassim, Adetola A. Payne, Amanda B. Rodeghier, Mark Macklin, Eric A. Strunk, Robert C. DeBaun, Michael R. TI Forced Expiratory Volume in 1 Second Is Associated with Earlier Death in Sickle Cell Anemia SO BLOOD LA English DT Meeting Abstract C1 [Kassim, Adetola A.; DeBaun, Michael R.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Payne, Amanda B.] Ctr Dis Control & Prevent, Nashville, TN USA. [Rodeghier, Mark] Rodeghier Consultants, Chicago, IL USA. [Macklin, Eric A.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Strunk, Robert C.] Washington Univ, Sch Med, St Louis, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9KQ UT WOS:000349242702032 ER PT J AU Ortel, TL Beckman, M Muhlbaier, L Reyes, N Grant, A Tcheng, J Saber, I Thames, E AF Ortel, Thomas L. Beckman, Michele Muhlbaier, Lawrence Reyes, Nimia Grant, Althea Tcheng, James Saber, Ibrahim Thames, Elizabeth TI Venous Thromboembolism (VTE) Surveillance: Incidence, Characteristics, and Initial Treatment of VTE Patients SO BLOOD LA English DT Meeting Abstract C1 [Ortel, Thomas L.; Muhlbaier, Lawrence; Tcheng, James; Saber, Ibrahim] Duke Univ, Med Ctr, Durham, NC USA. [Beckman, Michele; Reyes, Nimia] Ctr Dis Control & Prevent, Atlanta, GA USA. [Grant, Althea] Ctr Dis Control, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9KQ UT WOS:000349242701189 ER PT J AU Paulukonis, S Griffin, T Zhou, M Eckman, JR Hagar, R Snyder, AB Feuchtbaum, L Grant, AM Hulihan, M AF Paulukonis, Susan Griffin, Todd Zhou, Mei Eckman, James R. Hagar, Robert Snyder, Angela Bauer Feuchtbaum, Lisa Grant, Althea M. Hulihan, Mary TI Sickle Cell Disease Mortality in California and Georgia 2004-2008 SO BLOOD LA English DT Meeting Abstract C1 [Paulukonis, Susan] Inst Publ Hlth, Richmond, CA USA. [Griffin, Todd] Georgia Dept Publ Hlth, Atlanta, GA USA. [Zhou, Mei; Snyder, Angela Bauer] Georgia Regents Univ, Atlanta, GA USA. [Eckman, James R.] Emory Univ, Med Ctr, Atlanta, GA 30322 USA. [Hagar, Robert] Childrens Hosp & Res Ctr Oakland, Oakland, CA USA. [Feuchtbaum, Lisa] Calif Dept Publ Hlth, Richmond, CA USA. [Grant, Althea M.] Natl Ctr Birth Defects & Disabil, Div Blood Disorders, Atlanta, GA USA. [Hulihan, Mary] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9KQ UT WOS:000349242702152 ER PT J AU Rhee, C Manzo, V Shea, T Desjardins, C van der Auwera, G Young, S Riley, AM DeAngelo, DJ Baden, LR Gee, J Meyerson, M Klompas, M Yokoe, D Weiser, L Pedamallu, CS Bhatt, AS AF Rhee, Chanu Manzo, Veronica Shea, Terrance Desjardins, Christopher van der Auwera, Geraldine Young, Sarah Riley, Ann Marie DeAngelo, Daniel J. Baden, Lindsey R. Gee, Jay Meyerson, Matthew Klompas, Michael Yokoe, Deborah Weiser, Linda Pedamallu, Chandra Sekhar Bhatt, Ami S. TI Bacillus Cereus: A Leukemia-Specific, Neuroinvasive Pathogen? SO BLOOD LA English DT Meeting Abstract C1 [Rhee, Chanu] Harvard Univ, Sch Med, Boston, MA USA. [Manzo, Veronica; Bhatt, Ami S.] Stanford Univ, Stanford, CA 94305 USA. [Shea, Terrance; Desjardins, Christopher; van der Auwera, Geraldine; Young, Sarah; Pedamallu, Chandra Sekhar] Broad Inst, Cambridge, MA USA. [Riley, Ann Marie] Boston Childrens Hosp, Boston, MA USA. [DeAngelo, Daniel J.; Meyerson, Matthew] Dana Farber Canc Inst, Boston, MA 02115 USA. [Baden, Lindsey R.; Klompas, Michael; Yokoe, Deborah; Weiser, Linda] Brigham & Womens Hosp, Boston, MA 02115 USA. [Gee, Jay] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 4 WC Hematology SC Hematology GA CA9KQ UT WOS:000349242707200 ER PT J AU Wendelboe, AM Campbell, J McCumber, M Ding, K Bratzler, D Beckman, M Reyes, N Raskob, GE AF Wendelboe, Aaron M. Campbell, Janis McCumber, Micah Ding, Kai Bratzler, Dale Beckman, Michele Reyes, Nimia Raskob, Gary E. TI Incidence of Venous Thromboembolism Estimated Using Hospital Discharge Data: Differences Between Event-Based Estimates and Patient-Based Estimates SO BLOOD LA English DT Meeting Abstract C1 [Wendelboe, Aaron M.; McCumber, Micah; Ding, Kai] Univ Oklahoma Hlth Sci, Coll Publ Hlth, Oklahoma City, OK USA. [Campbell, Janis] Univ Oklahoma, Coll Publ Hlth, Oklahoma City, OK USA. [McCumber, Micah; Ding, Kai; Bratzler, Dale] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Oklahoma City, OK USA. [Beckman, Michele; Reyes, Nimia] Ctr Dis Control & Prevent, Atlanta, GA USA. [Raskob, Gary E.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9KQ UT WOS:000349242703223 ER PT J AU Saber, I Thames, E Beckman, M Reyes, N Grant, A Ortel, TL AF Saber, Ibrahim Thames, Elizabeth Beckman, Michele Reyes, Nimia Grant, Althea Ortel, Thomas L. TI Autopsy-Proven Venous Thromboembolism (VTE): Incidence and Characteristics of Patients Correlated with Clinical Management Prior to Death SO BLOOD LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Hematology CY DEC 06-09, 2014 CL San Francisco, CA SP Amer Soc Hematol C1 [Saber, Ibrahim] Duke Univ Med Ctr, Duham, NC USA. [Thames, Elizabeth; Ortel, Thomas L.] Duke Univ Med Ctr, Durham, NC USA. [Beckman, Michele; Reyes, Nimia] Ctr Dis Control & Prevent, Atlanta, GA USA. [Grant, Althea] Ctr Dis Control, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA SN 0006-4971 EI 1528-0020 J9 BLOOD JI Blood PD DEC 6 PY 2014 VL 124 IS 21 PG 3 WC Hematology SC Hematology GA CA9HU UT WOS:000349233806173 ER PT J AU Powers, AM AF Powers, Ann M. TI Chikungunya virus control: is a vaccine on the horizon? SO LANCET LA English DT Editorial Material ID LA-REUNION-ISLAND; DENGUE VACCINES; EPIDEMIC; COST C1 Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. RP Powers, AM (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. EM apowers@cdc.gov NR 16 TC 7 Z9 8 U1 0 U2 22 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 EI 1474-547X J9 LANCET JI Lancet PD DEC 6 PY 2014 VL 384 IS 9959 BP 2008 EP 2009 DI 10.1016/S0140-6736(14)61290-3 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA AW6BD UT WOS:000346353600009 PM 25132506 ER PT J AU Cullen, KA Arguin, PM AF Cullen, Karen A. Arguin, Paul M. TI Malaria Surveillance - United States, 2012 SO MMWR SURVEILLANCE SUMMARIES LA English DT Article ID PLASMODIUM-FALCIPARUM; CHEMOPROPHYLAXIS; RESISTANCE; HAITI; KNOWLEDGE; ATTITUDES; TRAVELERS AB Problem/Condition: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the bite of an infective female Anopheles mosquito. The majority of malaria infections in the United States occur among persons who have traveled to regions with ongoing malaria transmission. However, malaria is also occasionally acquired by persons who have not traveled out of the country, through exposure to infected blood products, congenital transmission, laboratory exposure, or local mosquitoborne transmission. Malaria surveillance in the United States is conducted to identify episodes of local transmission and to guide prevention recommendations for travelers. Period Covered: This report summarizes cases in persons with onset of symptoms in 2012 and summarizes trends during previous years. Description of System: Malaria cases diagnosed by blood film, polymerase chain reaction, or rapid diagnostic tests are mandated to be reported to local and state health departments by health-care providers or laboratory staff. Case investigations are conducted by local and state health departments, and reports are transmitted to CDC through the National Malaria Surveillance System (NMSS), National Notifiable Diseases Surveillance System (NNDSS), or direct CDC consults. For the first time, CDC conducted antimalarial drug resistance testing on blood samples submitted to CDC by health-care providers or local/state health departments. Data from these reporting systems serve as the basis for this report. Results: CDC received 1,687 reported cases of malaria with an onset of symptoms in 2012 among persons in the United States, including 1,683 cases classified as imported, one laboratory-acquired case, one nosocomial case, and two cryptic cases. The total number of cases represents a 12% decrease from the 1,925 cases reported for 2011. Plasmodium falciparum, P. vivax, P. malariae, and P. ovale were identified in 58%, 17%, 3%, and 3% of cases, respectively. Twenty (1%) patients were infected by two species. The infecting species was unreported or undetermined in 17% of cases, a decrease of 6 percentage points from 2011. Polymerase chain reaction testing determined or corrected the species for 45 (43%) of the 104 samples submitted for drug resistance testing. Of the 909 patients who reported purpose of travel, 604 (66%) were visiting friends or relatives (VFR). Among the 983 cases in U.S. civilians for whom information on chemoprophylaxis use and travel region was known, 63 (6%) patients reported that they had followed and adhered to a chemoprophylaxis drug regimen recommended by CDC for the regions to which they had traveled. Thirty-two cases were reported in pregnant women, among whom only one adhered to chemoprophylaxis. Among all reported cases, 231 (14%) were classified as severe infections in 2012. Of these, six persons with malaria died in 2012. Beginning in 2012, there were 104 blood samples submitted to CDC that were tested for molecular markers associated with antimalarial drug resistance. Of the 65 P. falciparum-positive samples, 53 (82%) had genetic polymorphisms associated with pyrimethamine drug resistance, 61 (94%) with sulfadoxine resistance, 29 (45%) with chloroquine resistance, 1 (2%) with mefloquine drug resistance, 2 (3%) with atovaquone resistance, and none with artemisinin resistance. Interpretation: Despite the 12% decline in the number of cases reported in 2012 compared with 2011, the overall trend in malaria cases has been increasing since 1973. Although progress has been made in reducing the global burden of malaria, the disease remains endemic in many regions, and the use of appropriate prevention measures by travelers is still inadequate. Public Health Actions: Completion of data elements on the malaria case report form increased slightly in 2012 compared with 2011, but still remains unacceptably low. This incomplete reporting compromises efforts to examine trends in malaria cases and prevent infections. VFRs continue to be a difficult population to reach with effective malaria prevention strategies. Evidence-based prevention strategies that effectively target VFRs need to be developed and implemented to have a substantial impact on the numbers of imported malaria cases in the United States. Although more patients reported taking chemoprophylaxis to prevent malaria, the majority reported not taking it, and adherence was poor among those who did take chemoprophylaxis. Proper use of malaria chemoprophylaxis will prevent the majority of malaria illness and reduce the risk for severe disease (http://www.cdc.gov/malaria/travelers/drugs.html). Malaria infections can be fatal if not diagnosed and treated promptly with antimalarial medications appropriate for the patient's age and medical history, the likely country of malaria acquisition, and previous use of antimalarial chemoprophylaxis. Recent molecular laboratory advances have enabled CDC to identify and conduct molecular surveillance of antimalarial drug resistance (http://www.cdc.gov/malaria/features/ars.html). These advances will allow CDC to track, guide treatment, and manage drug resistant malaria parasites both domestically and globally. For this to be successful, specimens should be submitted for cases diagnosed in the United States and for ongoing specimen collection and testing globally. Clinicians should consult the CDC Guidelines for Treatment of Malaria and contact the CDC's Malaria Hotline for case management advice when needed. Malaria treatment recommendations can be obtained online (http://www.cdc.gov/malaria/diagnosis_treatment) or by calling the Malaria Hotline (770-488-7788 or toll-free at 855-856-4713). C1 [Cullen, Karen A.; Arguin, Paul M.] CDC, Ctr Global Hlth, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA 30333 USA. RP Cullen, KA (reprint author), CDC, Ctr Global Hlth, Div Parasit Dis & Malaria, Malaria Branch, Atlanta, GA 30333 USA. FU CDC Antimicrobial Resistance Working Group FX The authors acknowledge the state, territorial, and local health departments; health-care providers; laboratories; and the AFHSC for providing this information to CDC. Laboratory support was provided by the malaria diagnostic reference laboratory and Luciana Silva-Flannery, Curtis Huber, Dragan Ljolje, Venkatachalam Udhayakumar, and John Barnwell obtained molecular surveillance data. Molecular surveillance work was supported by funds from CDC Antimicrobial Resistance Working Group. NR 52 TC 5 Z9 5 U1 0 U2 8 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 1545-8636 J9 MMWR SURVEILL SUMM JI MMWR Surv. Summ. PD DEC 5 PY 2014 VL 63 IS 12 BP 1 EP 26 PG 26 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AY5SC UT WOS:000347630900001 ER PT J AU Cullen, KA Arguin, PM AF Cullen, Karen A. Arguin, Paul M. TI Malaria Surveillance - United States, 2012 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID PLASMODIUM-FALCIPARUM; CHEMOPROPHYLAXIS; RESISTANCE; HAITI; KNOWLEDGE; ATTITUDES; TRAVELERS AB Problem/Condition: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the bite of an infective female Anopheles mosquito. The majority of malaria infections in the United States occur among persons who have traveled to regions with ongoing malaria transmission. However, malaria is also occasionally acquired by persons who have not traveled out of the country, through exposure to infected blood products, congenital transmission, laboratory exposure, or local mosquitoborne transmission. Malaria surveillance in the United States is conducted to identify episodes of local transmission and to guide prevention recommendations for travelers. Period Covered: This report summarizes rases in persons with onset of symptoms in 2012 and summarizes trends during previous years. Description of System: Malaria cases diagnosed by blood film, polymerase chain reaction, or rapid diagnostic tests are mandated to be reported to local and state health departments by health-care providers or laboratory staff. Case investigations are conducted by local and state health departments, and reports are transmitted to CDC through the National Malaria Surveillance System (NMSS), National Notifiable Diseases Surveillance System (NNDSS), or direct CDC consults. For the first time, CDC conducted antimalarial drug resistance testing on blood samples submitted to CDC by health-care providers or local/state health departments. Data from these reporting systems serve as the basis for this report. Results: CDC received 1,687 reported cases of malaria with an onset of symptoms in 2012 among persons in the United States, including 1,683 cases classified as imported, one laboratory-acquired case, one nosocomial case, and two cryptic cases. The total number of cases represents a 12% decrease from the 1,925 cases reported for 2011. Plasmodium falciparum, P vivax, P malariae, and P. ovale were identified in 58%, 17%, 3%, and 3% of cases, respectively. Twenty (1%) patients were infected by two species. The infecting species was unreported or undetermined in 17% of cases, a decrease of 6 percentage points from 2011. Polymerase chain reaction testing determined or corrected the species for 45 (43%) of the 104 samples submitted for drug resistance testing. Of the 909 patients who reported purpose of travel, 604 (66%) were visiting friends or relatives (VFR). Among the 983 cases in U.S. civilians for whom information on chemoprophylaxis use and travel region was known, 63 (6%) patients reported that they had followed and adhered to a chemoprophylaxis drug regimen recommended by CDC for the regions to which they had traveled. Thirty-two cases were reported in pregnant women, among whom only one adhered to chemoprophylaxis. Among all reported cases, 231 (14%) were classified as severe infections in 2012. Of these, six persons with malaria died in 2012. Beginning in 2012, there were 104 blood samples submitted to CDC that were tested for molecular markers associated with antimalarial drug resistance. Of the 65 P falciparum-positive samples, 53 (82%) had genetic polymorphisms associated with pyrimethamine drug resistance, 61 (94%) with sulfadoxine resistance, 29 (45%) with chloroquine resistance, 1 (2%) with mefloquine drug resistance, 2 (3%) with atovaquone resistance, and none with artemisinin resistance. Interpretation: Despite the 12% decline in the number of cases reported in 2012 compared with 2011, the overall trend in malaria cases has been increasing since 1973. Although progress has been made in reducing the global burden of malaria, the disease remains endemic in many regions, and the use of appropriate prevention measures by travelers is still inadequate. Public Health Actions: Completion of data elements on the malaria case report form increased slightly in 2012 compared with 2011, but still remains unacceptably low. This incomplete reporting compromises efforts to examine trends in malaria cases and prevent infections. VFRs continue to be a difficult population to reach with effective malaria prevention strategies. Evidencebased prevention strategies that effectively target VFRs need to be developed and implemented to have a substantial impact on the numbers of imported malaria cases in the United States. Although more patients reported taking chemoprophylaxis to prevent malaria, the majority reported not taking it, and adherence was poor among those who did take chemoprophylaxis. Proper use of malaria chemoprophylaxis will prevent the majority of malaria illness and reduce the risk for severe disease (http://www.cdc.gov/malaria/travelers/drugs.html). Malaria infections can be fatal if not diagnosed and treated promptly with antimalarial medications appropriate for the patient's age and medical history, the likely country of malaria acquisition, and previous use of antimalarial chemoprophylaxis. Recent molecular laboratory advances have enabled CDC to identify and conduct molecular surveillance of antimalarial drug resistance (http://www.cdc.gov/malaria/features/ars.html). These advances will allow CDC to track, guide treatment, and manage drug resistant malaria parasites both domestically and globally. For this to be successful, specimens should be submitted for cases diagnosed in the United States and for ongoing specimen collection and testing globally. Clinicians should consult the CDC Guidelines for Treatment of Malaria and contact the CDC's Malaria Hotline for case management advice when needed. Malaria treatment recommendations can be obtained online (http://www.cdc.gov/malaria/diagnosis_treatment) or by calling the Malaria Hotline (770-488-7788 or toll-free at 855-856-4713). C1 [Cullen, Karen A.; Arguin, Paul M.] CDC, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. RP Cullen, KA (reprint author), CDC, Malaria Branch, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30333 USA. FU CDC Antimicrobial Resistance Working Group FX The authors acknowledge the state, territorial, and local health departments; health-care providers; laboratories; and the AFHSC for providing this information to CDC. Laboratory support was provided by the malaria diagnostic reference laboratory and Luciana Silva-Flannery, Curtis Huber, Dragan Ljolje, Venkatachalam Udhayakumar, and John Barnwell obtained molecular surveillance data. Molecular surveillance work was supported by funds from CDC Antimicrobial Resistance Working Group. NR 51 TC 0 Z9 0 U1 0 U2 2 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 5 PY 2014 VL 63 IS 12 SU S BP 1 EP 22 PG 22 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX3CR UT WOS:000346818700001 ER PT J AU Drexler, N Miller, M Gerding, J Todd, S Adams, L Dahlgren, FS Bryant, N Weis, E Herrick, K Francies, J Komatsu, K Piontkowski, S Velascosoltero, J Shelhamer, T Hamilton, B Eribes, C Brock, A Sneezy, P Goseyun, C Bendle, H Hovet, R Williams, V Massung, R McQuiston, JH AF Drexler, Naomi Miller, Mark Gerding, Justin Todd, Suzanne Adams, Laura Dahlgren, F. Scott Bryant, Nelva Weis, Erica Herrick, Kristen Francies, Jessica Komatsu, Kenneth Piontkowski, Stephen Velascosoltero, Jose Shelhamer, Timothy Hamilton, Brian Eribes, Carmen Brock, Anita Sneezy, Patsy Goseyun, Cye Bendle, Harty Hovet, Regina Williams, Velda Massung, Robert McQuiston, Jennifer H. TI Community-Based Control of the Brown Dog Tick in a Region with High Rates of Rocky Mountain Spotted Fever, 2012-2013 SO PLOS ONE LA English DT Article ID RHIPICEPHALUS-SANGUINEUS TICKS; UNITED-STATES; BORNE DISEASES; LYME-DISEASE; RICKETTSIA-RICKETTSII; EASTERN ARIZONA; PREVENTION; IXODIDAE; ACARI; PREVALENCE AB Rocky Mountain spotted fever (RMSF) transmitted by the brown dog tick (Rhipicephalus sanguineus sensu lato) has emerged as a significant public health risk on American Indian reservations in eastern Arizona. During 2003-2012, more than 250 RMSF cases and 19 deaths were documented among Arizona's American Indian population. The high case fatality rate makes community-level interventions aimed at rapid and sustained reduction of ticks urgent. Beginning in 2012, a two year pilot integrated tick prevention campaign called the RMSF Rodeo was launched in a, similar to 600-home tribal community with high rates of RMSF. During year one, long-acting tick collars were placed on all dogs in the community, environmental acaricides were applied to yards monthly, and animal care practices such as spay and neuter and proper tethering procedures were encouraged. Tick levels, indicated by visible inspection of dogs, tick traps and homeowner reports were used to monitor tick presence and evaluate the efficacy of interventions throughout the project. By the end of year one, <1% of dogs in the RMSF Rodeo community had visible tick infestations five months after the project was started, compared to 64% of dogs in Non-Rodeo communities, and environmental tick levels were reduced below detectable levels. The second year of the project focused on use of the long-acting collar alone and achieved sustained tick control with fewer than 3% of dogs in the RMSF Rodeo community with visible tick infestations by the end of the second year. Homeowner reports of tick activity in the domestic and peridomestic setting showed similar decreases in tick activity compared to the non-project communities. Expansion of this successful project to other areas with Rhipicephalus-transmitted RMSF has the potential to reduce brown dog tick infestations and save human lives. C1 [Drexler, Naomi; Todd, Suzanne; Dahlgren, F. Scott; Bryant, Nelva; Massung, Robert; McQuiston, Jennifer H.] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. [Miller, Mark; Gerding, Justin] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA. [Todd, Suzanne; Adams, Laura] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA. [Adams, Laura; Weis, Erica; Herrick, Kristen; Francies, Jessica; Komatsu, Kenneth] Arizona Dept Hlth Serv, Dept Publ Hlth Serv, Phoenix, AZ 85007 USA. [Weis, Erica] Intertribal Council Arizona Inc, Tribal Epidemiol Ctr, Phoenix, AZ USA. [Piontkowski, Stephen; Velascosoltero, Jose; Shelhamer, Timothy] Indian Hlth Serv, Off Environm Hlth & Engn, Phoenix Area Unit, Phoenix, AZ USA. [Hamilton, Brian] Indian Hlth Serv, Phoenix Area Unit, Phoenix, AZ USA. RP Drexler, N (reprint author), Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. EM isj3@cdc.gov FU CDC Emerging Infections funds; PetSmart Charities; Indian Health Service and Housing and Urban Development; Centers for Disease Control and Prevention; Arizona Department of Health Services; Intertribal Council of Arizona Inc.; U.S. Department of Agriculture; Indian Health Service; Tribe B. Students and staff at North Carolina State University; Virginia-Maryland Regional College of Veterinary Medicine FX Parts of this project were funded with CDC Emerging Infections funds. Spay and neuter services were partially provided through a grant from PetSmart Charities (http://www.petsmartcharities.org/pro/grants/spay-neuter) managed by the CDC Foundation. Bayer Healthcare donated Seresto collars and Bayer Advanced acaricidal spray that were used during the project. Funding provided by Indian Health Service and Housing and Urban Development permitted purchase of collars and product and spay-neuter services in 2013. Additionally, financial and personnel contributions have been provided by the Centers for Disease Control and Prevention, the Arizona Department of Health Services, Intertribal Council of Arizona Inc., U.S. Department of Agriculture, Indian Health Service, and Tribe B. Students and staff at North Carolina State University and the Virginia-Maryland Regional College of Veterinary Medicine donated their time in 2012 to help provide free spay and neuter capabilities to the tribe. Grantors had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 35 TC 7 Z9 8 U1 2 U2 16 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 5 PY 2014 VL 9 IS 12 AR e112368 DI 10.1371/journal.pone.0112368 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AX4MS UT WOS:000346907200009 PM 25479289 ER PT J AU Sharp, TM Roth, NM Torres, J Ryff, KR Rodriguez, NMP Mercado, C Padro, MDD Ramos, M Phillips, R Lozier, M Arriola, CS Johansson, M Hunsperger, E Munoz-Jordan, JL Margolis, HS Garcia, BR AF Sharp, Tyler M. Roth, Nicole M. Torres, Jomil Ryff, Kyle R. Rodriguez, Nicole M. Perez Mercado, Chanis Padro, Maria del Pilar Diaz Ramos, Maria Phillips, Raina Lozier, Matthew Arriola, Carmen S. Johansson, Michael Hunsperger, Elizabeth Munoz-Jordan, Jorge L. Margolis, Harold S. Garcia, Brenda Rivera TI Chikungunya Cases Identified Through Passive Surveillance and Household Investigations - Puerto Rico, May 5-August 12, 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID DENGUE VIRUS TRANSMISSION; INFECTION; ARTHRALGIA; DIAGNOSIS; EPIDEMIC; CHILDREN; DISEASE; BURDEN C1 [Sharp, Tyler M.; Roth, Nicole M.; Rodriguez, Nicole M. Perez; Johansson, Michael; Hunsperger, Elizabeth; Munoz-Jordan, Jorge L.; Margolis, Harold S.] CDC, Natl Ctr Emerging & Zoonot Infect Dis, Div Vector Borne Dis, Atlanta, GA 30333 USA. [Torres, Jomil; Ryff, Kyle R.; Mercado, Chanis; Padro, Maria del Pilar Diaz; Ramos, Maria; Garcia, Brenda Rivera] Puerto Rico Dept Hlth, Off Epidemiol, Jefferson City, MO USA. [Phillips, Raina] CDC, Natl Ctr Environm Hlth, Div Environm Hazards & Hlth Effects, Atlanta, GA 30333 USA. [Phillips, Raina; Lozier, Matthew; Arriola, Carmen S.] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA. [Lozier, Matthew] CDC, Natl Ctr Immunizat & Resp Dis, Influenza Div, Atlanta, GA 30333 USA. [Arriola, Carmen S.] CDC, Ctr Global Hlth, Div Global Hlth Protect, Atlanta, GA 30333 USA. RP Sharp, TM (reprint author), CDC, Natl Ctr Emerging & Zoonot Infect Dis, Div Vector Borne Dis, Atlanta, GA 30333 USA. EM tsharp@cdc.gov NR 19 TC 17 Z9 17 U1 0 U2 8 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 5 PY 2014 VL 63 IS 48 BP 1121 EP 1128 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AU6XS UT WOS:000345745600001 PM 25474032 ER PT J AU Haynes, AK Prill, MM Iwane, MK Gerber, SI AF Haynes, Amber K. Prill, Mila M. Iwane, Marika K. Gerber, Susan I. TI Respiratory Syncytial Virus - United States, July 2012-June 2014 SO MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT LA English DT Article ID YOUNG-CHILDREN; SURVEILLANCE; INFECTION; SEASON C1 [Haynes, Amber K.; Prill, Mila M.; Iwane, Marika K.; Gerber, Susan I.] CDC, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30333 USA. RP Haynes, AK (reprint author), CDC, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30333 USA. EM ahaynes1@cdc.gov NR 9 TC 14 Z9 14 U1 1 U2 2 PU CENTER DISEASE CONTROL & PREVENTION PI ATLANTA PA MAILSTOP E-90, ATLANTA, GA 30333 USA SN 0149-2195 EI 1545-861X J9 MMWR-MORBID MORTAL W JI MMWR-Morb. Mortal. Wkly. Rep. PD DEC 5 PY 2014 VL 63 IS 48 BP 1133 EP 1136 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AU6XS UT WOS:000345745600003 PM 25474034 ER PT J AU Cohen, SM Hu, XH Sweeney, P Johnson, AS Hall, HI AF Cohen, Stacy M. Hu, Xiaohong Sweeney, Patricia Johnson, Anna Satcher Hall, H. Irene TI HIV Viral Suppression Among Persons With Varying Levels of Engagement in HIV Medical Care, 19 US Jurisdictions SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV continuum of care; HIV surveillance; viral suppression; retention in HIV care ID UNITED-STATES; ANTIRETROVIRAL THERAPY; PREVENTION; INFECTION; RETENTION; ASSOCIATION; ADHERENCE; SOCIETY AB Background: Ongoing HIV medical care is vital in achieving and maintaining viral suppression. We examined viral suppression applying retention in care definitions used by various federal agencies. Methods: Using National HIV Surveillance System data from 19 US jurisdictions with complete CD4 and viral load reporting, we determined viral suppression among persons who met the National HIV/AIDS Strategy retention in care definition (>= 2 visits >= 3 months apart; "retained in continuous care") and among those who had evidence of care but did not meet the definition ("engaged in care"). We also examined viral suppression among persons who met the Health and Human Services Core Indicator definition for retention. Results: Of 338,959 persons living with diagnosed HIV infection in 19 areas in 2010, 63.7% received any care; of these, 19.7% were "engaged in care" and 80.3% were "retained in continuous care." Of those "engaged in care," 47.7% achieved viral suppression compared with 73.6% of persons " retained in continuous care." Significant differences were evident for all subpopulations within each care category; younger persons and blacks/African Americans had lower levels of viral suppression than their counterparts. Persons " engaged in care," regardless of sex, age, race/ethnicity, and transmission category, had significantly lower percentages of viral suppression than persons " retained in continuous care." Similar patterns of viral suppression were found for persons meeting the Health and Human Services definition compared with persons " retained in continuous care." Conclusions: Higher levels of engagement in care, including more frequent monitoring of CD4 and viral load, were associated with viral suppression. C1 [Cohen, Stacy M.; Hu, Xiaohong; Sweeney, Patricia; Johnson, Anna Satcher; Hall, H. Irene] Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div HIV AIDS Prevent, Atlanta, GA 30333 USA. RP Cohen, SM (reprint author), Ctr Dis Control & Prevent, Natl Ctr HIV AIDS Viral Hepatitis STD & TB Preven, Div HIV AIDS Prevent, 1600 Clifton Rd,MS E-47, Atlanta, GA 30333 USA. EM fsk5@cdc.gov FU US Government FX Supported by US Government work. NR 30 TC 12 Z9 12 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 5 PY 2014 VL 67 IS 5 BP 519 EP 527 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AT2NW UT WOS:000344772300014 PM 25230292 ER PT J AU Kristiansen, PA Ba, AK Ouedraogo, AS Sanou, I Ouedraogo, R Sangare, L Diomande, F Kandolo, D Saga, IM Misegades, L Clark, TA Preziosi, MP Caugant, DA AF Kristiansen, Paul A. Ba, Absatou Ky Ouedraogo, Abdoul-Salam Sanou, Idrissa Ouedraogo, Rasmata Sangare, Lassana Diomande, Fabien Kandolo, Denis Saga, Inger Marie Misegades, Lara Clark, Thomas A. Preziosi, Marie-Pierre Caugant, Dominique A. TI Persistent low carriage of serogroup A Neisseria meningitidis two years after mass vaccination with the meningococcal conjugate vaccine, MenAfriVac SO BMC INFECTIOUS DISEASES LA English DT Article DE Neisseria meningitidis; Carriage; Meningitis; Burkina Faso; Conjugate vaccine; MLST; Meningitis belt; MenAfriVac; Herd immunity ID BURKINA-FASO; HERD-IMMUNITY; PNEUMOCOCCAL CONJUGATE; DISEASE; AFRICA; IMMUNIZATION; EPIDEMIC; IMPACT; W135; IDENTIFICATION AB Background: The conjugate vaccine against serogroup A Neisseria meningitidis (NmA), MenAfriVac, is currently being introduced throughout the African meningitis belt. In repeated multicentre cross-sectional studies in Burkina Faso we demonstrated a significant effect of vaccination on NmA carriage for one year following mass vaccination in 2010. A new multicentre carriage study was performed in October-November 2012, two years after MenAfriVac mass vaccination. Methods: Oropharyngeal samples were collected and analysed for presence of N. meningitidis (Nm) from a representative selection of 1-29-year-olds in three districts in Burkina Faso using the same procedures as in previous years. Characterization of Nm isolates included serogrouping, multilocus sequence typing, and porA and fetA sequencing. A small sample of invasive isolates collected during the epidemic season of 2012 through the national surveillance system were also analysed. Results: From a total of 4964 oropharyngeal samples, overall meningococcal carriage prevalence was 7.86%. NmA prevalence was 0.02% (1 carrier), significantly lower (OR, 0.05, P = 0.005, 95% CI, 0.006-0.403) than pre-vaccination prevalence (0.39%). The single NmA isolate was sequence type (ST)-7, P1.20,9; F3-1, a clone last identified in Burkina Faso in 2003. Nm serogroup W (NmW) dominated with a carriage prevalence of 6.85%, representing 87.2% of the isolates. Of 161 NmW isolates characterized by molecular techniques, 94% belonged to the ST-11 clonal complex and 6% to the ST-175 complex. Nm serogroup X (NmX) was carried by 0.60% of the participants and ST-181 accounted for 97% of the NmX isolates. Carriage prevalence of serogroup Y and non-groupable Nm was 0.20% and 0.18%, respectively. Among the 20 isolates recovered from meningitis cases, NmW dominated (70%), followed by NmX (25%). ST-2859, the only ST with a serogroup A capsule found in Burkina Faso since 2004, was not found with another capsule, neither among carriage nor invasive isolates. Conclusions: The significant reduction of NmA carriage still persisted two years following MenAfriVac vaccination, and no cases of NmA meningitis were recorded. High carriage prevalence of NmW ST-11 was consistent with the many cases of NmW meningitis in the epidemic season of 2012 and the high proportion of NmW ST-11 among the characterized invasive isolates. C1 [Kristiansen, Paul A.; Saga, Inger Marie; Caugant, Dominique A.] WHO, Norwegian Inst Publ Hlth, Collaborating Ctr Reference & Res Meningococci, Oslo, Norway. [Ba, Absatou Ky] Lab Natl Sante Publ, Ouagadougou, Burkina Faso. [Ouedraogo, Abdoul-Salam; Sanou, Idrissa] Univ Souro Sanou, Ctr Hosp, Bobo Dioulasso, Burkina Faso. [Sanou, Idrissa; Sangare, Lassana] Univ Yalgado, Ctr Hosp, Ouagadougou, Burkina Faso. [Ouedraogo, Rasmata] Univ Pediat Charles Gaulle, Ctr Hosp, Ouagadougou, Burkina Faso. [Diomande, Fabien; Kandolo, Denis] WHO, Inter Country Support Team, Ouagadougou, Burkina Faso. [Diomande, Fabien; Misegades, Lara; Clark, Thomas A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Preziosi, Marie-Pierre] Meningitis Vaccine Project, Ferney, France. [Preziosi, Marie-Pierre] WHO, Initiat Vaccine Res, CH-1211 Geneva, Switzerland. [Caugant, Dominique A.] Univ Oslo, Fac Med, Oslo, Norway. RP Kristiansen, PA (reprint author), WHO, Norwegian Inst Publ Hlth, Collaborating Ctr Reference & Res Meningococci, Oslo, Norway. EM paul.kristiansen@fhi.no FU Research Council of Norway [185784, 196327] FX This project was supported by the Research Council of Norway [grants numbers 185784, 196327 to DAC]. NR 50 TC 12 Z9 12 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD DEC 4 PY 2014 VL 14 AR 663 DI 10.1186/s12879-014-0663-4 PG 11 WC Infectious Diseases SC Infectious Diseases GA AX6CX UT WOS:000347012100001 PM 25472422 ER PT J AU Jones, J Stephenson, R Smith, DK Toledo, L La Pointe, A Taussig, J Sullivan, PS AF Jones, Jeb Stephenson, Rob Smith, Dawn K. Toledo, Lauren La Pointe, Allison Taussig, Jennifer Sullivan, Patrick S. TI Acceptability and willingness among men who have sex with men (MSM) to use a tablet-based HIV risk assessment in a clinical setting SO SPRINGERPLUS LA English DT Article DE HIV risk; Pre-exposure prophylaxis; HIV risk assessment; Men who have sex with men ID SCREENING BLOOD-DONORS; HEALTH-CARE PROVIDERS; PREEXPOSURE PROPHYLAXIS; UNITED-STATES; PREVENTION; PHYSICIAN; INTERVIEW; HISTORY; COMMUNICATION; TRANSMISSION AB We developed an iPad-based application to administer an HIV risk assessment tool in a clinical setting. We conducted focus group discussions (FGDs) with gay, bisexual and other men who have sex with men (MSM) to assess their opinions about using such a device to share risk behavior information in a clinical setting. Participants were asked about their current assessment of their risk or any risk reduction strategies that they discussed with their healthcare providers. Participants were then asked to provide feedback about the iPad-based risk assessment, their opinions about using it in a clinic setting, and suggestions on how the assessment could be improved. FGD participants were generally receptive to the idea of using an iPad-based risk assessment during healthcare visits. Based on the results of the FGDs, an iPad-based risk assessment is a promising method for identifying those patients at highest risk for HIV transmission. C1 [Jones, Jeb; Taussig, Jennifer; Sullivan, Patrick S.] Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA. [Stephenson, Rob] Emory Univ, Dept Global Hlth, Atlanta, GA 30322 USA. [Smith, Dawn K.; Toledo, Lauren] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Toledo, Lauren] ICF Int, Atlanta, GA USA. [La Pointe, Allison] Minnesota Dept Hlth, St Paul, MN USA. RP Jones, J (reprint author), Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA. EM jeb.jones@emory.edu FU Center for AIDS Research at Emory University [P30AI050409] FX The authors wish to thank Peter Carr and Theodore Bonau for their assistance with focus group facilitation and participant recruitment in Minneapolis. This research was funded by the Center for AIDS Research at Emory University (P30AI050409). NR 36 TC 4 Z9 4 U1 1 U2 1 PU SPRINGER INTERNATIONAL PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 2193-1801 J9 SPRINGERPLUS JI SpringerPlus PD DEC 2 PY 2014 VL 3 AR 708 DI 10.1186/2193-1801-3-708 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA CO4HG UT WOS:000359121200004 PM 25525569 ER PT J AU White, JA Blum, JS Hosken, NA Marshak, JO Duncan, L Zhu, CC Norton, EB Clements, JD Koelle, DM Chen, DX Weldon, WC Oberste, MS Lal, M AF White, Jessica A. Blum, Jeremy S. Hosken, Nancy A. Marshak, Joshua O. Duncan, Lauren Zhu, Changcheng Norton, Elizabeth B. Clements, John D. Koelle, David M. Chen, Dexiang Weldon, William C. Oberste, M. Steven Lal, Manjari TI Serum and mucosal antibody responses to inactivated polio vaccine after sublingual immunization using a thermoresponsive gel delivery system SO HUMAN VACCINES & IMMUNOTHERAPEUTICS LA English DT Article DE adjuvants; dmLT; mucosal immune response; poliovirus; sublingual immunization; thermoresponsive gel; vaccine delivery ID IMMUNE-RESPONSES; ESCHERICHIA-COLI; TH17 RESPONSES; SABIN STRAINS; ADJUVANT; IGA; IMMUNOGENICITY; NEUTRALIZATION; STRATEGIES; SECRETIONS AB Administering vaccines directly to mucosal surfaces can induce both serum and mucosal immune responses. Mucosal responses may prevent establishment of initial infection at the port of entry and subsequent dissemination to other sites. The sublingual route is attractive for mucosal vaccination, but both a safe, potent adjuvant and a novel formulation are needed to achieve an adequate immune response. We report the use of a thermoresponsive gel (TRG) combined with a double mutant of a bacterial heat-labile toxin (dmLT) for sublingual immunization with a trivalent inactivated poliovirus vaccine (IPV) in mice. This TRG delivery system, which changes from aqueous solution to viscous gel upon contact with the mucosa at body temperature, helps to retain the formulation at the site of delivery and has functional adjuvant activity from the inclusion of dmLT. IPV was administered to mice either sublingually in the TRG delivery system or intramuscularly in phosphate-buffered saline. We measured poliovirus type-specific serum neutralizing antibodies as well as polio-specific serum Ig and IgA antibodies in serum, saliva, and fecal samples using enzyme-linked immunosorbent assays. Mice receiving sublingual vaccination via the TRG delivery system produced both mucosal and serum antibodies, including IgA. Intramuscularly immunized animals produced only serum neutralizing and binding Ig but no detectable IgA. This study provides proof of concept for sublingual immunization using the TRG delivery system, comprising a thermoresponsive gel and dmLT adjuvant. C1 [White, Jessica A.; Blum, Jeremy S.; Duncan, Lauren; Zhu, Changcheng; Chen, Dexiang; Lal, Manjari] PATH, Seattle, WA 98121 USA. [Hosken, Nancy A.; Marshak, Joshua O.; Koelle, David M.] Univ Washington, Dept Med, Seattle, WA USA. [Koelle, David M.] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA. [Koelle, David M.] Fred Hutchinson Canc Res Inst, Vaccine & Infect Dis Div, Seattle, WA USA. [Koelle, David M.] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA. [Norton, Elizabeth B.; Clements, John D.] Tulane Univ, Sch Med, Dept Microbiol & Immunol, New Orleans, LA 70112 USA. [Weldon, William C.; Oberste, M. Steven] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. RP Lal, M (reprint author), PATH, Seattle, WA 98121 USA. EM mlal@path.org FU Bill & Melinda Gates Foundation FX This work was funded by grants from the Bill & Melinda Gates Foundation. The views expressed herein are solely those of the authors and do not necessarily reflect the views of the Gates Foundation or the Centers for Disease Control and Prevention. NR 60 TC 5 Z9 5 U1 2 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 2164-5515 EI 2164-554X J9 HUM VACC IMMUNOTHER JI Human Vaccines Immunother. PD DEC 2 PY 2014 VL 10 IS 12 BP 3611 EP 3621 PG 11 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA CG6HA UT WOS:000353398100033 PM 25483682 ER PT J AU Wong, KK Shi, JR Gao, HJ Zheteyeva, YA Lane, K Copeland, D Hendricks, J McMurray, L Sliger, K Rainey, JJ Uzicanin, A AF Wong, Karen K. Shi, Jianrong Gao, Hongjiang Zheteyeva, Yenlik A. Lane, Kimberly Copeland, Daphne Hendricks, Jennifer McMurray, LaFrancis Sliger, Kellye Rainey, Jeanette J. Uzicanin, Amra TI Why Is School Closed Today? Unplanned K-12 School Closures in the United States, 2011-2013 SO PLOS ONE LA English DT Article ID INFLUENZA-A H1N1; PANDEMIC INFLUENZA; OUTBREAK; LESSONS; SANDY AB Introduction: We describe characteristics of unplanned school closures (USCs) in the United States over two consecutive academic years during a non-pandemic period to provide context for implementation of school closures during a pandemic. Methods: From August 1, 2011 through June 30, 2013, daily systematic internet searches were conducted for publicly announced USCs lasting >= 1 day. The reason for closure and the closure dates were recorded. Information on school characteristics was obtained from the National Center for Education Statistics. Results: During the two-year study period, 20,723 USCs were identified affecting 27,066,426 students. Common causes of closure included weather (79%), natural disasters (14%), and problems with school buildings or utilities (4%). Only 771 (4%) USCs lasted >= 4 school days. Illness was the cause of 212 (1%) USCs; of these, 126 (59%) were related to respiratory illnesses and showed seasonal variation with peaks in February 2012 and January 2013. Conclusions: USCs are common events resulting in missed school days for millions of students. Illness causes few USCs compared with weather and natural disasters. Few communities have experience with prolonged closures for illness. C1 [Wong, Karen K.; Shi, Jianrong; Gao, Hongjiang; Zheteyeva, Yenlik A.; Copeland, Daphne; Rainey, Jeanette J.; Uzicanin, Amra] Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. [Lane, Kimberly] Chenega Govt Consulting, Chesapeake, VA USA. [Hendricks, Jennifer; McMurray, LaFrancis; Sliger, Kellye] Oak Ridge Associated Univ, Oak Ridge, TN USA. RP Uzicanin, A (reprint author), Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Atlanta, GA 30333 USA. EM auzicanin@cdc.gov FU United States Centers for Disease Control and Prevention FX This study was supported by the United States Centers for Disease Control and Prevention (http://www.cdc.gov/). Several co-authors are or were employees (KW HG YZ DC JR AU) or contractors (JS KL) of the US CDC at the time of the study, and their roles in the study design, data collection and analysis, decision to publish, and preparation of the manuscript are described in the Author Contributions. NR 29 TC 0 Z9 0 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 2 PY 2014 VL 9 IS 12 AR e113755 DI 10.1371/journal.pone.0113755 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AU8TQ UT WOS:000345869700049 PM 25463353 ER PT J AU Soo, JC Lee, T Kashon, M Kusti, M Harper, M AF Soo, Jhy-Charm Lee, Taekhee Kashon, Michael Kusti, Mohannad Harper, Martin TI Quartz in Coal Dust Deposited on Internal Surface of Respirable Size Selective Samplers SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE LA English DT Article ID WALL DEPOSITS; FILTER; CASSETTE AB The objective of the present study is to quantify quartz mass in coal dust deposited on the internal cassette surface of respirable size-selective samplers. Coal dust was collected with four different respirable size-selective samplers (10mm Dorr-Oliver nylon [Sensidyne, St. Petersburg, Fla.], SKC Aluminum [SKC Inc., Eighty Four, Pa.], BGI4L [BGI USA Inc., Waltham, Mass.], and GK2.69 cyclones [BGI USA Inc.]) with two different cassette types (polystyrene and static-dissipative polypropylene cassettes). The coal dust was aerosolized in a calm air chamber by using a fluidized bed aerosol generator without neutralization under the assumption that the procedure is similar to field sampling conditions. The mass of coal dust was measured gravimetrically and quartz mass was determined by Fourier transform infrared spectroscopy according to the National Institute for Occupational Safety and Health (NIOSH) Manual of Analytical Methods, Method 7603. The mass fractions of the total quartz sample on the internal cassette surface are significantly different between polystyrene and static-dissipative cassettes for all cyclones (p < 0.05). No consistent relationship between quartz mass on cassette internal surface and coal dust filter mass was observed. The BGI4L cyclone showed a higher (but not significantly) and the GK2.69 cyclone showed a significantly lower (p < 0.05) internal surface deposit quartz mass fraction for polystyrene cassettes compared to other cyclones. This study confirms previous observations that the interior surface deposits in polystyrene cassettes attached to cyclone pre-selectors can be a substantial part of the sample, and therefore need to be included in any analysis for accurate exposure assessment. On the other hand, the research presented here supports the position that the internal surface deposits in static-dissipative cassettes used with size-selective cyclones are negligible and that it is only necessary to analyze the filter catch. C1 [Soo, Jhy-Charm; Lee, Taekhee; Kusti, Mohannad; Harper, Martin] NIOSH, Exposure Assessment Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA. [Kashon, Michael] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA. RP Lee, T (reprint author), 1095 Willowdale Rd M-S 3030, Morgantown, WV 26505 USA. EM fwc8@cdc.gov FU Intramural CDC HHS [CC999999] NR 17 TC 6 Z9 6 U1 0 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 1545-9624 EI 1545-9632 J9 J OCCUP ENVIRON HYG JI J. Occup. Environ. Hyg. PD DEC 2 PY 2014 VL 11 IS 12 BP D215 EP D219 DI 10.1080/15459624.2014.960575 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AS6JP UT WOS:000344370200001 PM 25204985 ER PT J AU Morales-Aleman, MM Sutton, MY AF Morales-Aleman, Mercedes M. Sutton, Madeline Y. TI Hispanics/Latinos and the HIV continuum of care in the Southern USA: a qualitative review of the literature, 2002-2013 SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV LA English DT Article DE Hispanics; Latinos; HIV; Southern USA; testing; care ID SOUTHEASTERN UNITED-STATES; TASK-FORCE RECOMMENDATION; NORTH-CAROLINA; HISPANIC MEN; IMMIGRANT LATINOS; RISK; PREVENTION; INFECTION; SERVICES; DETERMINANTS AB Hispanics/Latinos are disproportionately affected by HIV infection, but access HIV care less often than non-Hispanic whites in the USA. The majority of new HIV diagnoses among Hispanics/Latinos occur in the southern USA; however, data are lacking regarding factors associated with HIV care access for Hispanics/Latinos in the South. We conducted a qualitative review of peer-reviewed articles using the HIV continuum of care framework to assess HIV care for Hispanics/Latinos in the US South. We identified 13 studies conducted in southern states that were informed by the continuum of care: testing and diagnosis of HIV infection (n = 9); linkage and retention in care (n = 2); and prescription of and adherence to ART (n = 2). Barriers to health care access included stigma, lack of Spanish-speaking health-care providers, and fear of deportation. Facilitators to health care access included provider endorsement of HIV tests and regular health care. Innovative solutions (e.g., patient navigators), tailored strategies (e.g., community outreach) and organizational-level interventions (e.g., increasing provider endorsement of HIV tests) can improve access for Hispanics/Latinos in the South C1 [Morales-Aleman, Mercedes M.; Sutton, Madeline Y.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30329 USA. RP Sutton, MY (reprint author), Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA 30329 USA. EM msutton@cdc.gov NR 35 TC 3 Z9 3 U1 3 U2 10 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0954-0121 EI 1360-0451 J9 AIDS CARE JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv PD DEC 2 PY 2014 VL 26 IS 12 BP 1592 EP 1604 DI 10.1080/09540121.2014.936817 PG 13 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Respiratory System; Social Sciences, Biomedical SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychology; Respiratory System; Biomedical Social Sciences GA AR2LH UT WOS:000343417200022 PM 25027357 ER PT J AU Kendall, T Danel, I Cooper, D Dilmitis, S Kaida, A Kourtis, AP Langer, A Lapidos-Salaiz, I Lathrop, E Moran, AC Sebitloane, H Turan, JM Watts, DH Wegner, MN AF Kendall, Tamil Danel, Isabella Cooper, Diane Dilmitis, Sophie Kaida, Angela Kourtis, Athena P. Langer, Ana Lapidos-Salaiz, Ilana Lathrop, Eva Moran, Allisyn C. Sebitloane, Hannah Turan, Janet M. Watts, D. Heather Wegner, Mary Nell TI Eliminating Preventable HIV-Related Maternal Mortality in Sub-Saharan Africa: What Do We Need to Know? SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV; maternal health; maternal mortality; research priorities; women's health; pregnancy ID INTIMATE-PARTNER VIOLENCE; TO-CHILD TRANSMISSION; ACTIVE ANTIRETROVIRAL THERAPY; CLUSTER-RANDOMIZED-TRIAL; INFECTED PREGNANT-WOMEN; SOUTH-AFRICA; CONTRACEPTIVE UPTAKE; INCREASED RISK; CARE; HEALTH AB Introduction: HIV makes a significant contribution to maternal mortality, and women living in sub-Saharan Africa are most affected. International commitments to eliminate preventable maternal mortality and reduce HIV-related deaths among pregnant and postpartum women by 50% will not be achieved without a better understanding of the links between HIV and poor maternal health outcomes and improved health services for the care of women living with HIV (WLWH) during pregnancy, childbirth, and postpartum. Methods: This article summarizes priorities for research and evaluation identified through consultation with 30 international researchers and policymakers with experience in maternal health and HIV in sub-Saharan Africa and a review of the published literature. Results: Priorities for improving the evidence about effective interventions to reduce maternal mortality and improve maternal health among WLWH include better quality data about causes of maternal death among WLWH, enhanced and harmonized program monitoring, and research and evaluation that contributes to improving: (1) clinical management of pregnant and postpartum WLWH, including assessment of the impact of expanded antiretroviral therapy on maternal mortality and morbidity, (2) integrated service delivery models, and (3) interventions to create an enabling social environment for women to begin and remain in care. Conclusions: As the global community evaluates progress and prepares for new maternal mortality and HIV targets, addressing the needs of WLWH must be a priority now and after 2015. Research and evaluation on maternal health and HIV can increase collaboration on these 2 global priorities, strengthen political constituencies and communities of practice, and accelerate progress toward achievement of goals in both areas. C1 [Kendall, Tamil; Langer, Ana; Wegner, Mary Nell] Harvard Univ, Sch Publ Hlth, Maternal Hlth Task Force, Women & Hlth Initiat,Dept Global Hlth & Populat, Boston, MA 02115 USA. [Danel, Isabella; Kourtis, Athena P.] Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA USA. [Cooper, Diane] Univ Cape Town, Sch Publ Hlth & Family Med, Womens Hlth Res Unit, ZA-7925 Cape Town, South Africa. [Kaida, Angela] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC V5A 1S6, Canada. [Lapidos-Salaiz, Ilana] US Agcy Int Dev, Off HIV AIDS, Washington, DC 20523 USA. [Lathrop, Eva] Emory Univ, Sch Med, Dept Gynecol & Obstet, Atlanta, GA USA. [Moran, Allisyn C.] US Agcy Int Dev, Off Hlth Infect Dis & Nutr, Washington, DC 20523 USA. [Sebitloane, Hannah] Univ KwaZulu Natal, Dept Obstet & Gynecol, Nelson R Mandela Sch Med, Durban, South Africa. [Turan, Janet M.] Univ Alabama Birmingham, Sch Publ Hlth, Dept Hlth Care Org & Policy, Birmingham, AL 35294 USA. [Watts, D. Heather] US Dept State, Off US Global AIDS Coordinator, Washington, DC 20520 USA. RP Kendall, T (reprint author), Harvard Univ, Sch Publ Hlth, Maternal Hlth Task Force, Women & Hlth Initiat,Dept Global Hlth & Populat, 665 Huntington Ave, Boston, MA 02115 USA. EM tkendall@hsph.harvard.edu FU Maternal Health Task Force - Bill & Melinda Gates Foundation [01065000621]; US Centers for Disease Control and Prevention FX Supported by the Maternal Health Task Force, which is supported through grant #01065000621 from the Bill & Melinda Gates Foundation, and the US Centers for Disease Control and Prevention. NR 91 TC 3 Z9 3 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 1 PY 2014 VL 67 SU 4 BP S250 EP S258 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA CH6BM UT WOS:000354120600012 PM 25436825 ER PT J AU Sinha, DN Palipudi, KM Oswal, K Gupta, PC Andes, LJ Asma, S AF Sinha, D. N. Palipudi, K. M. Oswal, K. Gupta, P. C. Andes, L. J. Asma, S. TI Influence of tobacco industry advertisements and promotions on tobacco use in India: Findings from the Global Adult Tobacco Survey 2009-2010 SO INDIAN JOURNAL OF CANCER LA English DT Article DE Adults; Global Adult Tobacco Survey; India; promotion and marketing; tobacco advertising; tobacco use ID ESTABLISHED SMOKING; ADOLESCENTS AB Introduction: The developing world, including countries like India, has become a major target for the tobacco industry to market its products. This study examines the influence of the marketing (advertising and promotion) of tobacco products on the use of tobacco by adults (ages 15 and over) in India. Method: Data from Global Adult Tobacco Survey 2009-2010 was analyzed using methods for complex (clustered) sample designs. Multivariate logistic regression was employed to predict the use of different tobacco products by level of exposure to tobacco marketing using adults who have never used tobacco as the reference category. Odds ratios (ORs) were adjusted for education, gender, age, state of residence, wealth index, and place of residence (urban/rural). Results: Adults in India were almost twice as likely to be current smokers (versus never users) when they were exposed to a moderate level of bidi or cigarette marketing. For bidis, among adults with high exposure, the OR for current use was 4.57 (95% confidence interval [CI]: 1.6, 13.0). Adults were more likely to be current users of smokeless tobacco (SLT) with even a low level of exposure to SLT marketing (OR = 1.24 [95% CI: 1.1, 1.4]). For SLT, the ORs showed an increasing trend (P for trend < 0.001) with greater level of exposure (moderate, OR = 1.55 [95% CI: 1.1, 2.2]; high, OR = 2.05 [95% CI: 0.8, 5.1]). The risk of any current tobacco use rose with increasing level of exposure to any marketing (minimum, OR = 1.25 [1.1-1.4]; moderate, OR = 1.38 [1.1-1.8]; and high, OR = 2.73 [1.8-4.2]), with the trend highly significant (P < 0.001). Conclusion: Exposure to the marketing of tobacco products, which may take the form of advertising at the point of sale, sales or a discounted price, free coupons, free samples, surrogate advertisements, or any of several other modalities, increased prevalence of tobacco use among adults. An increasing level of exposure to direct and indirect advertisement and promotion is associated with an increased likelihood of tobacco use. C1 [Sinha, D. N.] WHO, South East Asia Reg Off, New Delhi, India. [Palipudi, K. M.; Andes, L. J.; Asma, S.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Oswal, K.] Terna Dent Coll & Hosp, Bombay, Maharashtra, India. [Gupta, P. C.] Healis Sekhsaria Inst Publ Hlth, Bombay, Maharashtra, India. RP Sinha, DN (reprint author), WHO, South East Asia Reg Off, New Delhi, India. EM sinhad@who.int NR 19 TC 0 Z9 0 U1 2 U2 5 PU INDIAN CANCER SOC PI MUMBAI PA C/O DR D J JUSSAWALLA, EDITOR-IN-CHIEF, 74 JERBAI WADIA RD, PAREL, MUMBAI, 00000, INDIA SN 0019-509X EI 1998-4774 J9 INDIAN J CANCER JI Indian J. Cancer PD DEC PY 2014 VL 51 IS 5 SU 1 BP 13 EP 18 DI 10.4103/0019-509X.147424 PG 6 WC Oncology SC Oncology GA CF1CH UT WOS:000352280700004 ER PT J AU Palipudi, K Rizwan, SA Sinha, DN Andes, LJ Amarchand, R Krishnan, A Asma, S AF Palipudi, K. Rizwan, S. A. Sinha, D. N. Andes, L. J. Amarchand, R. Krishnan, A. Asma, S. TI Prevalence and sociodemographic determinants of tobacco use in four countries of the World Health Organization: South-East Asia region: Findings from the Global Adult Tobacco Survey SO INDIAN JOURNAL OF CANCER LA English DT Article DE Global Adult Tobacco Survey dual use; prevalence; South-East Asia Region; socioeconomic determinants; tobacco use ID DUAL-USE; SMOKELESS TOBACCO; SMOKING; INDIA; RISKS AB Introduction: Tobacco use is a leading cause of deaths and Disability Adjusted Life Years lost worldwide, particularly in South-East Asia. Health risks associated with exclusive use of one form of tobacco alone has a different health risk profile when compared to dual use. In order to tease out specific profiles of mutually exclusive categories of tobacco use, we carried out this analysis. Methods: The Global Adult Tobacco Survey (GATS) data was used to describe the profiles of three mutually exclusive tobacco use categories ("Current smoking only," "Current smokeless tobacco [SLT] use only," and "Dual use") in four World Health Organization South-East Asia Region countries, namely Bangladesh, India, Indonesia and Thailand. GATS was a nationally representative household-based survey that used a stratified multistage cluster sampling design proportional to population size. Prevalence of different forms of usage were described as proportions. Logistics regression analyses was performed to calculate odds ratios (OR) with 95% confidence intervals. All analyses were weighted, accounted for the complex sampling design and conducted using SPSS version 18. Results: The prevalence of different forms of tobacco use varied across countries. Current tobacco use ranged from 27.2% in Thailand to 43.3% in Bangladesh. Exclusively smoking was more common in Indonesia (34.0%) and Thailand (23.4%) and less common in Bangladesh (16.1%) and India (8.7%). Exclusively using SLT was more common in Bangladesh (20.3%) and India (20.6%) and less common on Indonesia (0.9%) and Thailand (3.5%). Dual use of smoking and SLT was found in Bangladesh (6.8%) and India (5.3%), but was negligible in Indonesia (0.8) and Thailand (0.4%). Gender, age, education and wealth had significant effects on the OR for most forms of tobacco use across all four countries with the exceptions of SLT use in Indonesia and dual use in both Indonesia and Thailand. In general, the different forms of tobacco use increased among males and with increasing age; and decreased with higher education and wealth. The results for urban versus rural residence were mixed and frequently not significant once controlling for the other demographic factors. Conclusion: This study addressed the socioeconomic disparities, which underlie health inequities due to tobacco use. Tobacco control activities in these countries should take in account local cultural, social and demographic factors for successful implementation. C1 [Palipudi, K.; Andes, L. J.; Asma, S.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Rizwan, S. A.; Amarchand, R.] INCLEN Trust Int, New Delhi, India. [Sinha, D. N.] WHO, South East Asia Reg Off, New Delhi, India. [Krishnan, A.] All India Inst Med Sci, Ctr Community Med, New Delhi 110029, India. RP Palipudi, K (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. EM gou8@cdc.gov RI S A, Rizwan/F-5289-2014 OI S A, Rizwan/0000-0002-3140-2614 FU Bloomberg Initiative to Reduce Tobacco Use, a program of Bloomberg Philanthropies FX Funding for the Global Adult Tobacco Survey (GATS) is provided by the Bloomberg Initiative to Reduce Tobacco Use, a program of Bloomberg Philanthropies. The Government of India contributed to GATS implementation in India. NR 28 TC 6 Z9 6 U1 1 U2 5 PU INDIAN CANCER SOC PI MUMBAI PA C/O DR D J JUSSAWALLA, EDITOR-IN-CHIEF, 74 JERBAI WADIA RD, PAREL, MUMBAI, 00000, INDIA SN 0019-509X EI 1998-4774 J9 INDIAN J CANCER JI Indian J. Cancer PD DEC PY 2014 VL 51 IS 5 SU 1 BP 24 EP 32 DI 10.4103/0019-509X.147446 PG 9 WC Oncology SC Oncology GA CF1CH UT WOS:000352280700006 ER PT J AU Sinha, DN Palipudi, KM Jones, CK Khadka, BB Silva, PD Mumthaz, M Shein, NNN Gyeltshen, T Nahar, K Asma, S Kyaing, NN AF Sinha, D. N. Palipudi, K. M. Jones, C. K. Khadka, B. B. Silva, P. D. Mumthaz, M. Shein, N. N. N. Gyeltshen, T. Nahar, K. Asma, S. Kyaing, N. N. TI Levels and trends of smokeless tobacco use among youth in countries of the World Health Organization South-East Asia Region SO INDIAN JOURNAL OF CANCER LA English DT Article DE Global Youth Tobacco Survey; smokeless tobacco use; trends; World Health Organization South-East Asia region; youth AB Background: At least two rounds of the Global Youth Tobacco Survey (GYTS) have been completed in most of the countries in the World Health Organization South-East Asia region. Comparing findings from these two rounds provides trend data on smokeless tobacco (SLT) use for the first time. Methods: This study uses GYTS data from Bangladesh, Bhutan, India, Indonesia, Maldives, Myanmar, Nepal, Sri Lanka, Thailand, and Timor-Leste during 2006-2013. GYTS is a nationally representative survey of 13-15-year-old students using a consistent and standard protocol. Current SLT use is defined as using any kind of SLT products, such as chewing betel quid or nonbetel quid or snuffing any other products orally or through the nasal route, during the 30 days preceding the survey. Prevalence and 95% confidence intervals were computed using SAS/SUDAAN software. Results: According to most recent GYTS data available in each country, the prevalence of current use of SLT among youth varied from 5.7% in Thailand to 23.2% in Bhutan; among boys, from 7.1% in Bangladesh to 27.2% in Bhutan; and among girls, from 3.7% in Bangladesh to 19.8% in Bhutan. Prevalence of SLT was reported significantly higher among boys than girls in Bhutan (boys 27.2%; girls 19.8%), India (boys 11.1%; girls 6.0%), Maldives (boys 9.2%; girls 2.9%), Myanmar (boys 15.2%; girls 4.0%), and Sri Lanka (boys 13.0%; girls 4.1%). Prevalence of current SLT use increased in Bhutan from 9.4% in 2009 to 23.2% in 2013, and in Nepal from 6.1% in 2007 to 16.2% in 2011. Conclusion: The findings call for countries to implement corrective measures through strengthened policy and enforcement. C1 [Sinha, D. N.; Kyaing, N. N.] WHO, Reg Off South East Asia New Delhi, New Delhi, India. [Palipudi, K. M.; Jones, C. K.; Asma, S.] Ctr Dis Control & Prevent, Global Tobacco Control, Off Smoking & Hlth, Atlanta, GA USA. [Khadka, B. B.] Govt Nepal, Minist Hlth & Populat, Informat Commun Ctr, Natl Hlth Educ, Kathmandu, Nepal. [Silva, P. D.] Minist Hlth & Nutr, Colombo, Sri Lanka. [Mumthaz, M.] Minist Educ, Male, Maldives. [Shein, N. N. N.] Govt Myanmar, Minist Hlth, Naypyidaw, Myanmar. [Gyeltshen, T.] Govt Bhutan, Minist Hlth, Thimphu, Bhutan. [Nahar, K.] Natl Ctr Control Rheumat Fever & Heart Dis, Dhaka, Bangladesh. RP Sinha, DN (reprint author), WHO, Reg Off South East Asia New Delhi, New Delhi, India. EM sinhad@who.int NR 8 TC 2 Z9 2 U1 1 U2 1 PU INDIAN CANCER SOC PI MUMBAI PA C/O DR D J JUSSAWALLA, EDITOR-IN-CHIEF, 74 JERBAI WADIA RD, PAREL, MUMBAI, 00000, INDIA SN 0019-509X EI 1998-4774 J9 INDIAN J CANCER JI Indian J. Cancer PD DEC PY 2014 VL 51 IS 5 SU 1 BP 50 EP 53 DI 10.4103/0019-509X.147472 PG 4 WC Oncology SC Oncology GA CF1CH UT WOS:000352280700010 ER PT J AU Sinha, DN Palipudi, KM Gupta, PC Singhal, S Ramasundarahettige, C Jha, P Indrayan, A Asma, S Vendhan, G AF Sinha, D. N. Palipudi, K. M. Gupta, P. C. Singhal, S. Ramasundarahettige, C. Jha, P. Indrayan, A. Asma, S. Vendhan, G. TI Smokeless tobacco use: A meta-analysis of risk and attributable mortality estimates for India SO INDIAN JOURNAL OF CANCER LA English DT Article DE Attributable mortality; current users; population attributable fraction; relative risk; tobacco chewing ID SMOKING; CANCER; BANGLADESH; SMOKERS; COHORT; MUMBAI AB Background: Use of smokeless tobacco (SLT) is widely prevalent in India and Indian subcontinent. Cohort and case-control studies in India and elsewhere report excess mortality due to its use. Objective: The aim was to estimate the SLT use-attributable deaths in males and females, aged 35 years and older, in India. Materials And Methods: Prevalence of SLT use in persons aged 35 years and older was obtained from the Global Adult Tobacco Survey in India and population size and deaths in the relevant age-sex groups were obtained from UN estimates (2010 revision) for 2008. A meta-relative risk (RR) based population attributable fraction was used to estimate attributable deaths in persons aged 35 years and older. A random effects model was used in the meta-analysis on all-cause mortality from SLT use in India including four cohort and one case-control study. The studies included in the meta-analysis were adjusted for smoking, age and education. Results: The prevalence of SLT use in India was 25.2% for men and 24.5% for women aged 35 years and older. RRs for females and males were 1.34 (1.27-1.42) and 1.17 (1.05-1.42), respectively. The number of deaths attributable to SLT use in India is estimated to be 368127 (217,076 women and 151,051 men), with nearly three-fifth (60%) of these deaths occurring among women. Con Clusion: SLT use caused over 350,000 deaths in India in 2010, and nearly three-fifth of SLT use-attributable deaths were among women in India. This calls for targeted public health intervention focusing on SLT products especially among women. C1 [Sinha, D. N.] WHO, Reg Off South East Asia, New Delhi, India. [Palipudi, K. M.; Asma, S.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Gupta, P. C.] Healis Sekhsaria Inst Publ Hlth, Navi Mumbai, Maharashtra, India. [Singhal, S.; Ramasundarahettige, C.; Jha, P.] St Michaels Hosp, Toronto, ON M5B 1W8, Canada. [Singhal, S.; Ramasundarahettige, C.; Jha, P.] Univ Toronto, Toronto, ON, Canada. [Indrayan, A.] Univ Delhi, Coll Med Sci, Ex Dept Biostat & Med Informat, New Delhi, India. [Vendhan, G.] Epidemiol Res Ctr, Madras, Tamil Nadu, India. RP Sinha, DN (reprint author), WHO, Reg Off South East Asia, New Delhi, India. EM sinhad@who.int NR 34 TC 2 Z9 2 U1 0 U2 6 PU INDIAN CANCER SOC PI MUMBAI PA C/O DR D J JUSSAWALLA, EDITOR-IN-CHIEF, 74 JERBAI WADIA RD, PAREL, MUMBAI, 00000, INDIA SN 0019-509X EI 1998-4774 J9 INDIAN J CANCER JI Indian J. Cancer PD DEC PY 2014 VL 51 IS 5 SU 1 BP 73 EP 77 DI 10.4103/0019-509X.147477 PG 5 WC Oncology SC Oncology GA CF1CH UT WOS:000352280700014 ER PT J AU Paige, SB Frost, SDW Gibson, MA Jones, JH Shankar, A Switzer, WM Ting, N Goldberg, TL AF Paige, Sarah B. Frost, Simon D. W. Gibson, Mhairi A. Jones, James Holland Shankar, Anupama Switzer, William M. Ting, Nelson Goldberg, Tony L. TI Beyond Bushmeat: Animal Contact, Injury, and Zoonotic Disease Risk in Western Uganda SO ECOHEALTH LA English DT Article DE zoonotic disease; Uganda; Kibale National Park; risk factors ID KIBALE NATIONAL-PARK; CROSS-SPECIES TRANSMISSION; FOREST FRAGMENTATION; NONHUMAN-PRIMATES; INFECTIONS; EPIDEMIOLOGY; POPULATION; LIVESTOCK; WILDLIFE; COLOBUS AB Zoonotic pathogens cause an estimated 70% of emerging and re-emerging infectious diseases in humans. In sub-Saharan Africa, bushmeat hunting and butchering is considered the primary risk factor for human-wildlife contact and zoonotic disease transmission, particularly for the transmission of simian retroviruses. However, hunting is only one of many activities in sub-Saharan Africa that bring people and wildlife into contact. Here, we examine human-animal interaction in western Uganda, identifying patterns of injuries from animals and contact with nonhuman primates. Additionally, we identify individual-level risk factors associated with contact. Nearly 20% (246/1,240) of participants reported either being injured by an animal or having contact with a primate over their lifetimes. The majority (51.7%) of injuries were dog bites that healed with no long-term medical consequences. The majority (76.8%) of 125 total primate contacts involved touching a carcass; however, butchering (20%), hunting (10%), and touching a live primate (10%) were also reported. Red colobus (Piliocolobus rufomitratus tephrosceles) accounted for most primate contact events. Multivariate logistic regression indicated that men who live adjacent to forest fragments are at elevated risk of animal contact and specifically primate contact. Our results provide a useful comparison to West and Central Africa where "bushmeat hunting" is the predominant paradigm for human-wildlife contact and zoonotic disease transmission. C1 [Paige, Sarah B.; Goldberg, Tony L.] Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53706 USA. [Frost, Simon D. W.] Univ Cambridge, Dept Vet Med, Cambridge, England. [Gibson, Mhairi A.] Univ Bristol, Dept Archaeol & Anthropol, Bristol, Avon, England. [Jones, James Holland] Stanford Univ, Woods Inst Environm, Dept Anthropol, Stanford, CA 94305 USA. [Shankar, Anupama; Switzer, William M.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Ting, Nelson] Univ Oregon, Dept Anthropol, Eugene, OR 97403 USA. [Goldberg, Tony L.] Global Hlth Inst, Madison, WI 53706 USA. RP Goldberg, TL (reprint author), Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53706 USA. EM tgoldberg@vetmed.wisc.edu RI Frost, Simon/F-3648-2010; OI Frost, Simon/0000-0002-5207-9879; Jones, James/0000-0003-1680-6757 FU Royal Society Wolfson Research Merit Award; NIH as part of the joint NIH-NSF Ecology of Infectious Disease program [TW009237]; UK Economic and Social Research Council FX Kibale EcoHealth Project Field Staff: Joseph Abwooki Byaruhanga, John Atwooki Rusoke, Patrick Akiiki Katurama, Annet Abwooki Nyamwija, Alice Akiiki Mbabazi; Geoffrey Weny. SDWF is supported in part by a Royal Society Wolfson Research Merit Award. This work was funded by NIH Grant TW009237 as part of the joint NIH-NSF Ecology of Infectious Disease program and the UK Economic and Social Research Council. NR 37 TC 9 Z9 10 U1 8 U2 39 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1612-9202 EI 1612-9210 J9 ECOHEALTH JI EcoHealth PD DEC PY 2014 VL 11 IS 4 BP 534 EP 543 DI 10.1007/s10393-014-0942-y PG 10 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA CE5HB UT WOS:000351860800011 PM 24845574 ER PT J AU Kenney, JL Solberg, OD Langevin, SA Brault, AC AF Kenney, Joan L. Solberg, Owen D. Langevin, Stanley A. Brault, Aaron C. TI Characterization of a novel insect-specific flavivirus from Brazil: potential for inhibition of infection of arthropod cells with medically important flaviviruses SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID WEST-NILE-VIRUS; NATURAL MOSQUITO POPULATION; POLYMERASE-CHAIN-REACTION; TICK-BORNE FLAVIVIRUSES; 3 UNTRANSLATED REGION; KAMITI RIVER VIRUS; FUSING AGENT VIRUS; CULEX FLAVIVIRUS; DIRECT REPEATS; GENETIC-CHARACTERIZATION AB In the past decade, there has been an upsurge in the number of newly described insect-specific flaviviruses isolated pan-globally. We recently described the isolation of a novel flavivirus (tentatively designated 'Nhumirim virus'; NHUV) that represents an example of a unique subset of apparently insect-specific viruses that phylogenetically affiliate with dual-host mosquito-borne flaviviruses despite appearing to be limited to replication in mosquito cells. We characterized the in vitro growth potential and 3' untranslated region (UTR) sequence homology with alternative flaviviruses, and evaluated the virus's capacity to suppress replication of representative Culex spp.-vectored pathogenic flaviviruses in mosquito cells. Only mosquito cell lines were found to support NHUV replication, further reinforcing the insect-specific phenotype of this virus. Analysis of the sequence and predicted RNA secondary structures of the 3' UTR indicated NHUV to be most similar to viruses within the yellow fever serogroup and Japanese encephalitis serogroup, and viruses in the tick-borne flavivirus clade. NHUV was found to share the fewest conserved sequence elements when compared with traditional insect-specific flaviviruses. This suggests that, despite apparently being insect specific, this virus probably diverged from an ancestral mosquito-borne flavivirus. Co-infection experiments indicated that prior or concurrent infection of mosquito cells with NHUV resulted in a significant reduction in virus production of West Nile virus (WNV), St Louis encephalitis virus (SLEV) and Japanese encephalitis virus. The inhibitory effect was most effective against WNV and SLEV with over a 10(6)-fold and 10(4)-fold reduction in peak titres, respectively. C1 [Kenney, Joan L.; Brault, Aaron C.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Solberg, Owen D.; Langevin, Stanley A.] Sandia Natl Labs, Livermore, CA USA. RP Brault, AC (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. EM abrault@cdc.gov FU ASM/CDC postdoctoral fellowship; US Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000] FX We would like to thank Alex Pauvolid-Correa and Nick Komar for providing the isolate and for their helpful discussions in the preparation of this manuscript. We would like to thank Robert Tesh for providing the amphibian cell line, Nisha Duggal and Goro Kuno for reviewing the manuscript and Tamara Gritsun for advice on the 3' UTR analysis. J. L. K. was supported by an ASM/CDC postdoctoral fellowship. Sandia is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the US Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. NR 71 TC 20 Z9 21 U1 0 U2 10 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 EI 1465-2099 J9 J GEN VIROL JI J. Gen. Virol. PD DEC PY 2014 VL 95 BP 2796 EP 2808 DI 10.1099/vir.0.068031-0 PN 12 PG 13 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA CD2YB UT WOS:000350943800023 PM 25146007 ER PT J AU Posner, SF Bowman, BA Collins, JL AF Posner, Samuel F. Bowman, Barbara A. Collins, Janet L. TI Considering Trends in Sodium, Trans Fat, and Saturated Fat as Key Metrics of Cardiometobolic Risk Reduction SO PREVENTING CHRONIC DISEASE LA English DT Editorial Material C1 [Bowman, Barbara A.; Collins, Janet L.] Natl Ctr Chron Dis Prevent & Hlth Promot, Ctr Dis Control & Prevent, Atlanta, GA USA. RP Posner, SF (reprint author), Preventing Chron Dis Publ Hlth Res Practice, 4770 Buford Hwy,MS F-80, Atlanta, GA 30341 USA. EM Shp5@cdc.gov NR 7 TC 0 Z9 0 U1 0 U2 0 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD DEC PY 2014 VL 11 AR E230 DI 10.5888/pcd11.140561 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB8BH UT WOS:000349852700020 PM 25551185 ER PT J AU Rodgers, L Conrey, EJ Wapner, A Ko, JY Dietz, PM Oza-Frank, R AF Rodgers, Loren Conrey, Elizabeth J. Wapner, Andrew Ko, Jean Y. Dietz, Patricia M. Oza-Frank, Reena TI Ohio Primary Health Care Providers' Practices and Attitudes Regarding Screening Women With Prior Gestational Diabetes for Type 2 Diabetes Mellitus-2010 SO PREVENTING CHRONIC DISEASE LA English DT Article ID GLUCOSE-INTOLERANCE; FOLLOW-UP; POSTPARTUM; PREGNANCY; RISK; HISTORY; DIAGNOSIS AB Introduction Gestational diabetes mellitus (GDM) is associated with a 7-fold increased lifetime risk for developing type 2 diabetes mellitus. Early diagnosis of type 2 diabetes is crucial for preventing complications. Despite recommendations for type 2 diabetes screening every 1 to 3 years for women with previous diagnoses of GDM and all women aged 45 years or older, screening prevalence is unknown. We sought to assess Ohio primary health care providers' practices and attitudes regarding assessing GDM history and risk for progression to type 2 diabetes. Methods During 2010, we mailed surveys to 1,400 randomly selected Ohio family physicians and internal medicine physicians; we conducted analyses during 2011-2013. Overall responses were weighted to adjust for stratified sampling. Chi-square tests compared categorical variables. Results Overall response rate was 34% (380 eligible responses). Among all respondents, 57% reported that all new female patients in their practices are routinely asked about GDM history; 62% reported screening women aged 45 years or younger with prior GDM every 1 to 3 years for glucose intolerance; and 42% reported that screening for type 2 diabetes among women with prior GDM is a high or very high priority in their practice. Conclusion Because knowing a patient's GDM history is the critical first step in the prevention of progression to type 2 diabetes for women who had GDM, suboptimal screening for both GDM history and subsequent glucose abnormalities demonstrates missed opportunities for identifying and counseling women with increased risk for type 2 diabetes. C1 [Conrey, Elizabeth J.; Ko, Jean Y.; Dietz, Patricia M.] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. [Conrey, Elizabeth J.; Wapner, Andrew] Ohio Dept Hlth, Columbus, OH 43266 USA. [Oza-Frank, Reena] Nationwide Childrens Hosp, Res Inst, Columbus, OH USA. [Oza-Frank, Reena] Ohio State Univ, Columbus, OH 43210 USA. RP Rodgers, L (reprint author), Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, MS A-19,1600 Clifton Rd NE, Atlanta, GA 30329 USA. EM lrodgers@cdc.gov NR 27 TC 0 Z9 0 U1 1 U2 4 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1545-1151 J9 PREV CHRONIC DIS JI Prev. Chronic Dis. PD DEC PY 2014 VL 11 AR E213 DI 10.5888/pcd11.140308 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CB8BH UT WOS:000349852700009 PM 25474385 ER PT J AU Howland, RE Madsen, AM Nicaj, L Noe, RS Casey-Lockyer, M Begier, E AF Howland, Renata E. Madsen, Ann M. Nicaj, Leze Noe, Rebecca S. Casey-Lockyer, Mary Begier, Elizabeth TI Assessing Electronic Death Registration and American Red Cross Systems for Mortality Surveillance During Hurricane Sandy, October 29-November 10, 2012, New York City SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS LA English DT Article DE hurricane; mortality; vital statistics; Red Cross; public health surveillance AB Objective: We briefly describe 2 systems that provided disaster-related mortality surveillance during and after Hurricane Sandy in New York City, namely, the New York City Health Department Electronic Death Registration System (EDRS) and the American Red Cross paper-based tracking system. Methods: Red Cross fatality data were linked with New York City EDRS records by using decedent name and date of birth. We analyzed cases identified by both systems for completeness and agreement across selected variables and the time interval between death and reporting in the system. Results: Red Cross captured 93% (41/44) of all Sandy-related deaths; the completeness and quality varied by item, and timeliness was difficult to determine. The circumstances leading to death captured by Red Cross were particularly useful for identifying reasons individuals stayed in evacuation zones. EDRS variables were nearly 100% complete, and the median interval between date of death and reporting was 6 days (range: 0-43 days). Conclusions: Our findings indicate that a number of steps have the potential to improve disaster-related mortality surveillance, including updating Red Cross surveillance forms and electronic databases to enhance timeliness assessments, greater collaboration across agencies to share and use data for public health preparedness, and continued expansion of electronic death registration systems. C1 [Howland, Renata E.; Madsen, Ann M.; Begier, Elizabeth] New York City Dept Hlth & Mental Hyg, Bur Vital Stat, New York, NY USA. [Noe, Rebecca S.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Chamblee, GA USA. [Casey-Lockyer, Mary] Amer Red Cross, Disaster Hlth Serv, Washington, DC 20006 USA. RP Howland, RE (reprint author), NYC Dept Hlth & Mental Hyg, Long Isl City, NY 11101 USA. EM rroney@health.nyc.gov FU Intramural CDC HHS [CC999999]; NCHM CDC HHS [U38 HM000414, 5U38HM000414-5] NR 6 TC 2 Z9 2 U1 1 U2 4 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1935-7893 EI 1938-744X J9 DISASTER MED PUBLIC JI Dis. Med. Public Health Prep. PD DEC PY 2014 VL 8 IS 6 BP 489 EP 491 DI 10.1017/dmp.2014.133 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA CA0KB UT WOS:000348605600007 PM 25859690 ER PT J AU Bardfield, J Agins, B Palumbo, M Wei, AL Morris, J Marston, B AF Bardfield, J. Agins, B. Palumbo, M. Wei, A. L. Morris, J. Marston, B. CA Cotrimoxazole Qi Grp TI Improving rates of cotrimoxazole prophylaxis in resource-limited settings: implementation of a quality improvement approach SO INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE LA English DT Article DE quality improvement; performance measurement; quality management; pepfar ID ANTIRETROVIRAL TREATMENT; COST-EFFECTIVENESS; HIV-INFECTION; MORTALITY; SYSTEMS; UGANDA AB Objective. To demonstrate the effectiveness of quality improvement methods to monitor and improve administration of cotrimoxazole (CTX) prophylaxis to improve health outcomes among adults living with HIV/AIDS in low resource countries. Design. Program evaluation. Setting. HIV/AIDS health care facilities in Uganda, Mozambique, Namibia and Haiti. Intervention. Performance measures based on national guidelines are developed in each country. These may include CD4 monitoring, ART adherence and uptake of CTX prophylaxis. CTX prophylaxis is routinely selected, because it has been shown to reduce HIV-related morbidity and mortality. Patient records are sampled using a standard statistical table to achieve a minimum confidence interval of 90% with a spread of +/- 8% in participating clinics. If an electronic medical record is available, all patients are reviewed. Routine review of performance measures, usually every 6 months, is conducted to identify gaps in care. Improvement interventions are developed and implemented at health facilities, informed by performance results, and local/national public health priorities. Main outcome measure. Median clinic rates of CTX prophylaxis. Results. Median performance rates of CTX prophylaxis generally improved for adult HIV+ patients between 2006 and 2013 across countries, with median clinic rates higher than baseline at follow-up in 16 of 18 groups of clinics implementing CTX -focused improvement projects. Conclusions. Quality management offers a data-driven method to improve the quality of HIV care in low resource countries. Application of improvement principles has been shown to be effective to increase the rates of CTX prophylaxis in national HIV programs in multiple countries. C1 [Bardfield, J.; Agins, B.; Palumbo, M.] HEALTHQUAL Int, AIDS Inst, New York State Dept Hlth, New York, NY 10007 USA. [Wei, A. L.] Univ Calif San Diego, San Diego Sch Med, La Jolla, CA 92093 USA. [Morris, J.] Baylor Coll Med, Houston, TX 77030 USA. [Marston, B.] CDC, Global AIDS Program, Atlanta, GA 30329 USA. RP Bardfield, J (reprint author), 90 Church St,13th Floor, New York, NY 10007 USA. EM jeb16@health.state.ny.us FU President's Emergency Plan for AIDS Relief through the US Department of Health and Human Services, Health Resources and Services Administration HIV/AIDS Bureau FX HEALTHQUAL International is funded by the President's Emergency Plan for AIDS Relief through the US Department of Health and Human Services, Health Resources and Services Administration HIV/AIDS Bureau. NR 21 TC 1 Z9 1 U1 0 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1353-4505 EI 1464-3677 J9 INT J QUAL HEALTH C JI Int. J. Qual. Health Care PD DEC 1 PY 2014 VL 26 IS 6 BP 613 EP 622 DI 10.1093/intqhc/mzu085 PG 10 WC Health Care Sciences & Services; Health Policy & Services SC Health Care Sciences & Services GA CA0KO UT WOS:000348606900006 PM 25335758 ER PT J AU Viney, K Brostrom, R Nasa, J Defang, R Kienene, T AF Viney, Kerri Brostrom, Richard Nasa, Joaquin Defang, Rupihner Kienene, Takeieta TI Diabetes and tuberculosis in the Pacific Islands region SO LANCET DIABETES & ENDOCRINOLOGY LA English DT Letter C1 [Viney, Kerri] Australian Natl Univ, Canberra, ACT 2601, Australia. [Brostrom, Richard] Ctr Dis Control & Prevent, Atlanta, GA USA. [Nasa, Joaquin] Kwajalein Atoll Hlth Care Serv, Ebeye, Marshall Island. [Defang, Rupihner] Pohnpei State Dept Hlth Serv, Kolonia, Pohnpei State, Micronesia. [Kienene, Takeieta] Kiribati Minist Hlth & Med Serv, Tarawa, Kiribati. RP Viney, K (reprint author), Australian Natl Univ, GPO Box 4, Canberra, ACT 2601, Australia. EM kerri.viney@hotmail.com OI Viney, Kerri/0000-0002-0453-4339 NR 5 TC 3 Z9 3 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2213-8587 J9 LANCET DIABETES ENDO JI Lancet Diabetes Endocrinol. PD DEC PY 2014 VL 2 IS 12 BP 932 EP 932 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA AY8BZ UT WOS:000347780700009 PM 25433427 ER PT J AU Pollack, KM Bailey, MM Gielen, AC Wolf, S Auld, ME Sleet, DA Lee, KK AF Pollack, Keshia M. Bailey, Maryanne M. Gielen, Andrea C. Wolf, Sarah Auld, M. Elaine Sleet, David A. Lee, Karen K. TI Building safety into active living initiatives SO PREVENTIVE MEDICINE LA English DT Article DE Safety; Wounds and injuries; Physical activity; Building design; Urban design AB Objective. Efforts to promote environmental designs that facilitate opportunities for physical activity should consider the fact that injuries are the leading cause of death for Americans ages 1 to 44, with transportation-related injuries the most common cause. Drawing on the latest research and best practices in the field of injury prevention, the purpose of this article is to provide those working to promote physical activity with evidence-based recommendations on building in safety while designing active environments. Method. A systematic review of the peer-reviewed and grey literature published from 1995 to 2012 was conducted to identify injury prevention strategies applicable to objectives in the Active Design Guidelines (ADG), which present design strategies for active living. Injury prevention strategies were rated according to the strength of the research evidence. Results. We identified 18 urban design strategies and 9 building design strategies that promote safety. Evidence was strong or emerging for 14/18 urban design strategies and 7/9 building design strategies. Conclusion. ADG strategies are often wholly compatible with well-accepted injury prevention principles. By partnering with architects and planners, injury prevention and public health professionals can help ensure that new and renovated spaces maximize both active living and safety. (C) 2014 Elsevier Inc. All rights reserved. C1 [Pollack, Keshia M.; Bailey, Maryanne M.] Johns Hopkins Bloomberg Sch Publ Hlth, Johns Hopkins Ctr Injury Res & Policy, Dept Hlth Policy & Management, Baltimore, MD USA. [Gielen, Andrea C.] Johns Hopkins Bloomberg Sch Publ Hlth, Johns Hopkins Ctr Injury Res & Policy, Dept Hlth Behav & Soc, Baltimore, MD USA. [Wolf, Sarah] New York City Dept Hlth & Mental Hyg, Bur Chron Dis Prevent & Tobacco Control, New York, NY USA. [Auld, M. Elaine] Soc Publ Hlth Educ, Washington, DC USA. [Sleet, David A.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. [Lee, Karen K.] New York City Dept Hlth & Mental Hyg, New York, NY USA. RP Pollack, KM (reprint author), 624 N Broadway,Room 557, Baltimore, MD 21205 USA. EM kpollac1@jhu.edu FU U.S. Centers for Disease Control and Prevention (CDC) [1U58DP000133] FX The authors thank Ms. Julia Chen for her help with the literature review. The authors also thank their Promoting Safety collaborators in the NYC Departments of Transportation, Parks and Recreation, and Buildings, and the Mayor's Office of People with Disabilities. The Office of Creative Services at the NYC Department of Design and Construction provided assistance with graphics and layout of the Promoting Safety document. Within the NYC Department of Health and Mental Hygiene, those working in injury surveillance and prevention also reviewed Promoting Safety and provided input. This work was supported by a cooperative agreement to the Society for Public Health Education from the U.S. Centers for Disease Control and Prevention (CDC) 1U58DP0001335. The findings and conclusions are those of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention. NR 9 TC 2 Z9 2 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 EI 1096-0260 J9 PREV MED JI Prev. Med. PD DEC PY 2014 VL 69 SU S BP S102 EP S105 DI 10.1016/j.ypmed.2014.08.010 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AY7LE UT WOS:000347740900018 PM 25117526 ER PT J AU Xiao, G Jones, RL Saunders, D Caldwell, KL AF Xiao, Ge Jones, Robert L. Saunders, David Caldwell, Kathleen L. TI DETERMINATION OF U-234/U-238, U-235/U-238 AND U-236/U-238 ISOTOPE RATIOS IN URINE USING SECTOR FIELD INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY SO RADIATION PROTECTION DOSIMETRY LA English DT Article ID GULF-WAR VETERANS; DEPLETED URANIUM; SMALL VOLUMES; FOLLOW-UP; SAMPLES; ICPMS; U-236; WATER; NAILS; HAIR AB Quantification of the isotopic composition of uranium in urine at low levels of concentration is important for assessing both military and civilian populations' exposures to uranium. However, until now there has been no convenient, precise method established for rapid determination of multiple uranium isotope ratios. Here, the authors report a new method to measure U-234/U-238, U-235/U-238 and U-236/U-238. It uses solid-phase chelation extraction (via TRU columns) of actinides from the urine matrix, followed by measurement using a magnetic sector field inductively coupled plasma mass spectrometer (SF-ICP-MS-Thermo Element XR) equipped with a high-efficiency nebulizer (Apex PFA microflow) and coupled with a membrane desolvating nebulizer system (Aridus II (TM)). This method provides rapid and reliable results and has been used successfully to analyse Certified Reference Materials. C1 [Xiao, Ge; Jones, Robert L.; Saunders, David; Caldwell, Kathleen L.] Ctr Dis Control & Prevent, Inorgan & Radiat Analyt Toxicol Branch, Atlanta, GA 30341 USA. RP Xiao, G (reprint author), Ctr Dis Control & Prevent, Inorgan & Radiat Analyt Toxicol Branch, 4770 Buford HWY,Mail Stop F50, Atlanta, GA 30341 USA. EM gxiao@cdc.gov FU CDC FX The funding for this work was from CDC federal government program funding. No outside funding used. NR 23 TC 2 Z9 2 U1 3 U2 24 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0144-8420 EI 1742-3406 J9 RADIAT PROT DOSIM JI Radiat. Prot. Dosim. PD DEC PY 2014 VL 162 IS 4 BP 618 EP 624 DI 10.1093/rpd/ncu023 PG 7 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA AY7IH UT WOS:000347733700022 PM 24563523 ER PT J AU Driscoll, AJ Karron, RA Bhat, N Thumar, B Kodani, M Fields, BS Whitney, CG Levine, OS O'Brien, KL Murdoch, DR AF Driscoll, Amanda J. Karron, Ruth A. Bhat, Niranjan Thumar, Bhagvanji Kodani, Maja Fields, Barry S. Whitney, Cynthia G. Levine, Orin S. O'Brien, Katherine L. Murdoch, David R. TI Evaluation of fast-track diagnostics and TaqMan array card real-time PCR assays for the detection of respiratory pathogens SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Respiratory; ALRI; PCR; Pneumonia; Molecular; Diagnostics ID VIRUSES AB Several commercial assays are now available to detect the nucleic acid of multiple respiratory pathogens from a single specimen. Head-to-head comparisons of such assays using a single set of standard specimens provide additional information about key assay parameters such as sensitivity, specificity and lower limits of detection, and help to inform the decision regarding which method to use. We evaluated two real-time PCR platforms: the Fast-track Diagnostics (R) (FTD) multiplex respiratory panel and a TaqMan array card (TAC) for simultaneous uniplex detection of multiple respiratory pathogens. Two sets of samples were used to evaluate the assays. One set was created by spiking pooled nasal wash or phosphate buffered saline with specified volumes of known concentrations of virus and/or bacteria. Clinical nasal wash specimens from children with lower respiratory tract illness comprised the other set. Thirteen pathogen targets were compared between the two platforms. Testing with a validation panel of spiked samples revealed a sensitivity of 96.1% and 92.9% for the FTD and TAC assays, respectively. Specificity could not be reliably calculated due to a suspected contamination of the sample substrate. Inter-assay agreement was high (>95%) for most targets. Previously untested clinical specimens tested by both assays revealed a high percent agreement (>95%) for all except rhinovirus, enterovirus and Streptococcus pneumoniae. Limitations of this evaluation included extraction of the validation samples by two different methods and the evaluation of the assays in different laboratories. However, neither of these factors significantly impacted inter-assay agreement for these sets of samples, and it was demonstrated that both assays could reliably detect clinically relevant concentrations of bacterial and viral pathogens. (C) 2014 Published by Elsevier B.V. C1 [Driscoll, Amanda J.; Levine, Orin S.; O'Brien, Katherine L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Int Vaccine Access Ctr, Baltimore, MD USA. [Karron, Ruth A.; Bhat, Niranjan; Thumar, Bhagvanji] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Bhat, Niranjan] Johns Hopkins Sch Med, Dept Pediat, Div Infect Dis, Baltimore, MD USA. [Kodani, Maja; Fields, Barry S.; Whitney, Cynthia G.] Ctr Dis Control & Prevent, Resp Dis Branch, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Murdoch, David R.] Univ Otago, Dept Pathol, Christchurch, New Zealand. [Murdoch, David R.] Canterbury Hlth Labs, Microbiol Unit, Christchurch, New Zealand. RP Driscoll, AJ (reprint author), Int Vaccine Access Ctr, 855 N Wolfe St 600, Baltimore, MD 21218 USA. EM adrisco1@jhu.edu FU Bill & Melinda Gates Foundation [48968] FX Funding: This work was supported by grant 48968 from The Bill & Melinda Gates Foundation to the International Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health. NR 10 TC 7 Z9 7 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 EI 1872-8359 J9 J MICROBIOL METH JI J. Microbiol. Methods PD DEC PY 2014 VL 107 BP 222 EP 226 DI 10.1016/j.mimet.2014.10.009 PG 5 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA AY5IM UT WOS:000347605900036 PM 25448378 ER PT J AU Elliott, JC Aharonovich, E O'Leary, A Johnston, B Hasin, DS AF Elliott, Jennifer C. Aharonovich, Efrat O'Leary, Ann Johnston, Barbara Hasin, Deborah S. TI Perceived Medical Risks of Drinking, Alcohol Consumption, and Hepatitis C Status Among Heavily Drinking HIV Primary Care Patients SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE HIV; Alcohol; Drinking; Risk; Hepatitis C ID INTERACTIVE TOXICITY BELIEFS; ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS; INTERVIEW SCHEDULE AUDADIS; COINFECTED PATIENTS; USE DISORDER; FIBROSIS PROGRESSION; REDUCTION SUPPORT; LIVER-DISEASE; INDIVIDUALS AB BackgroundHeavy drinking poses significant risks to the health and survival of individuals infected with HIV, particularly those coinfected with hepatitis C virus (HCV). However, little is known about patients' perceptions of these risks, and whether these perceptions relate to their alcohol consumption. MethodsA sample of 254 heavily drinking HIV primary care patients (78% male; 94.5% minority; 31.8% with HCV) reported on their perceptions of the medical risks of drinking and on their alcohol consumption prior to participation in a drinking-reduction intervention trial. ResultsIn the HIV-infected sample as a whole, 62.9% reported that they had a medical problem made worse by drinking, and 64.3% reported restricting drinking to avoid future medical problems. Although patients coinfected with HIV/HCV reported greater efforts to restrict drinking to avoid future medical problems (adjusted odds ratio=1.94), their reported drinking quantity and frequency did not differ from that of HIV mono-infected patients. Awareness of medical risk was not associated with drinking level. Effort to restrict drinking to avoid medical risk was associated with lower drinking quantity, frequency, and binge frequency (ps<0.05), but the association with binge frequency was specific to patients without HCV. ConclusionsOver one-third of HIV patients are unaware of the medical risks of drinking, and do not restrict use, suggesting the need for intervention in this group. Patients coinfected with HIV/HCV may report more effort to restrict drinking, but their reported drinking quantity and frequency suggest that they are actually drinking just as heavily as HIV mono-infected patients. Awareness of medical risk was unrelated to drinking, which suggests the need for interventions consisting of more than simple education. However, reported effort to restrict drinking did predict less drinking, suggesting the importance of patient commitment and initiative in change. C1 [Elliott, Jennifer C.; Hasin, Deborah S.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA. [Aharonovich, Efrat; Hasin, Deborah S.] Columbia Univ, Med Ctr, Dept Psychiat, New York, NY 10032 USA. [Aharonovich, Efrat; Hasin, Deborah S.] New York State Psychiat Inst & Hosp, New York, NY 10032 USA. [O'Leary, Ann] Ctr Dis Control & Prevent, Atlanta, GA USA. [Johnston, Barbara] Mt Sinai Hosp, Div Infect Dis, New York, NY 10029 USA. [Johnston, Barbara] Icahn Sch Med Mt Sinai, Div Infect Dis, New York, NY 10029 USA. RP Hasin, DS (reprint author), Columbia Univ, Med Ctr, Dept Psychiat, 1051 Riverside Dr 123, New York, NY 10032 USA. EM dsh2@columbia.edu FU New York State Psychiatric Institute; [R01AA014323]; [K05AA014223]; [T32DA031099]; [R01DA024606] FX This study was funded by grants R01AA014323, K05AA014223, T32DA031099, R01DA024606, and the New York State Psychiatric Institute. No conflict of interest is declared. The results and conclusions of this study are those of the authors and do not reflect official views of the Centers for Disease Control and Prevention. NR 36 TC 6 Z9 6 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-6008 EI 1530-0277 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD DEC PY 2014 VL 38 IS 12 BP 3052 EP 3059 DI 10.1111/acer.12570 PG 8 WC Substance Abuse SC Substance Abuse GA AY4IN UT WOS:000347541500022 PM 25581660 ER PT J AU Haegerich, TM Paulozzi, LJ Manns, BJ Jones, CM AF Haegerich, Tamara M. Paulozzi, Leonard J. Manns, Brian J. Jones, Christopher M. TI What we know, and don't know, about the impact of state policy and systems-level interventions on prescription drug overdose SO DRUG AND ALCOHOL DEPENDENCE LA English DT Review DE Prescribing; Opioids; Overdose; Policy; Evaluation; Pain ID NALOXONE DISTRIBUTION PROGRAMS; CHRONIC NONCANCER PAIN; NEW-YORK-CITY; OPIOID-OVERDOSE; UNITED-STATES; BENZODIAZEPINE PRESCRIPTION; INTRANASAL NALOXONE; MONITORING PROGRAMS; CLINICAL GUIDELINES; WASHINGTON-STATE AB Background: Drug overdose deaths have been rising since the early 1990s and is the leading cause of injury death in the United States. Overdose from prescription opioids constitutes a large proportion of this burden. State policy and systems-level interventions have the potential to impact prescription drug misuse and overdose. Methods: We searched the literature to identify evaluations of state policy or systems-level interventions using non-comparative, cross-sectional, before-after, time series, cohort, or comparison group designs or randomized/non-randomized trials. Eligible studies examined intervention effects on provider behavior, patient behavior, and health outcomes. Results: Overall study quality is low, with a limited number of time-series or experimental designs. Knowledge and prescribing practices were measured more often than health outcomes (e.g., overdoses). Limitations include lack of baseline data and comparison groups, inadequate statistical testing, small sample sizes, self-reported outcomes, and short-term follow-up. Strategies that reduce inappropriate prescribing and use of multiple providers and focus on overdose response, such as prescription drug monitoring programs, insurer strategies, pain clinic legislation, clinical guidelines, and naloxone distribution programs, are promising. Evidence of improved health outcomes, particularly from safe storage and disposal strategies and patient education, is weak. Conclusions: While important efforts are underway to affect prescriber and patient behavior, data on state policy and systems-level interventions are limited and inconsistent. Improving the evidence base is a critical need so states, regulatory agencies, and organizations can make informed choices about policies and practices that will improve prescribing and use, while protecting patient health. Published by Elsevier Ireland Ltd. C1 [Haegerich, Tamara M.] Ctr Dis Control & Prevent, Div Unint Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA 30341 USA. [Paulozzi, Leonard J.] Ctr Dis Control & Prevent, Div Unint Injury Prevent, Natl Ctr Injury Prevent & Control, El Paso, TX 79912 USA. [Manns, Brian J.] Ctr Dis Control & Prevent, Policy Res Anal & Dev Off, Off Associate Director Policy, Atlanta, GA 30029 USA. [Jones, Christopher M.] US PHS, CDR, Off Publ Hlth Strategy & Anal, Off Commissioner,USDA, Silver Spring, MD 20993 USA. RP Haegerich, TM (reprint author), Ctr Dis Control & Prevent, Div Unint Injury Prevent, Natl Ctr Injury Prevent & Control, 4770 Buford Hwy MS F62, Atlanta, GA 30341 USA. EM EQD4@cdc.gov; LBP4@cdc.gov; WMU6@cdc.gov; Christopher.M.Jones@fda.hhs.gov NR 112 TC 61 Z9 61 U1 6 U2 20 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0376-8716 EI 1879-0046 J9 DRUG ALCOHOL DEPEN JI Drug Alcohol Depend. PD DEC 1 PY 2014 VL 145 BP 34 EP 47 DI 10.1016/j.drugalcdep.2014.10.001 PG 14 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA AY3XL UT WOS:000347512700002 PM 25454406 ER PT J AU Blank, MB Himelhoch, SS Balaji, AB Metzger, DS Dixon, LB Rose, CE Oraka, E Davis-Vogel, A Thompson, WW Heffelfinger, JD AF Blank, Michael B. Himelhoch, Seth S. Balaji, Alexandra B. Metzger, David S. Dixon, Lisa B. Rose, Charles E. Oraka, Emeka Davis-Vogel, Annet Thompson, William W. Heffelfinger, James D. TI A Multisite Study of the Prevalence of HIV With Rapid Testing in Mental Health Settings SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID ANTIDEPRESSANT MEDICATION TREATMENT; RANDOMIZED CONTROLLED-TRIAL; PSYCHIATRIC-INPATIENTS; UNITED-STATES; UNDERSTANDING ASSOCIATIONS; HEPATITIS-C; NEW-YORK; ILLNESS; CARE; SEROPREVALENCE AB Objectives. We estimated HIV prevalence and risk factors among persons receiving mental health treatment in Philadelphia, Pennsylvania, and Baltimore, Maryland, January 2009 to August 2011. Methods. We used a multisite, cross-sectional design stratified by clinical setting. We tested 1061 individuals for HIV in university-based inpatient psychiatric units (n = 287), intensive case-management programs (n = 273), and community mental health centers (n = 501). Results. Fifty-one individuals (4.8%) were HIV-infected. Confirmed positive HIV tests were 5.9% (95% confidence interval [CI] = 3.7%, 9.4%) for inpatient units, 5.1% (95% CI = 3.1%, 8.5%) for intensive case-management programs, and 4.0% (95% CI = 2.6%, 6.1%) for community mental health centers. Characteristics associated with HIV included Black race, homosexual or bisexual identity, and HCV infection. Conclusions. HIV prevalence for individuals receiving mental health services was about 4 times as high as in the general population. We found a positive association between psychiatric symptom severity and HIV infection, indicating that engaging persons with mental illness in appropriate mental health treatment may be important to HIV prevention. These findings reinforce recommendations for routine HIV testing in all clinical settings to ensure that HIV-infected persons receiving mental health services are identified and referred to timely infectious disease care. C1 [Blank, Michael B.; Metzger, David S.] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA. [Himelhoch, Seth S.] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA. [Balaji, Alexandra B.; Rose, Charles E.; Heffelfinger, James D.] Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA. [Dixon, Lisa B.] Columbia Univ, Dept Psychiat, New York, NY USA. [Oraka, Emeka] ICF Int, Atlanta, GA USA. [Davis-Vogel, Annet] Univ Penn, HIV AIDS Prevent Res Div, Philadelphia, PA 19104 USA. [Thompson, William W.] Ctr Dis Control & Prevent, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. RP Blank, MB (reprint author), Ctr Mental Hlth Policy & Serv Res, Room 3020,3535 Market St, Philadelphia, PA 19104 USA. EM mblank2@upenn.edu RI Metzger, David/D-9499-2012 FU Multi-Site Rapid HIV Testing in Urban Community Mental Health Settings [U18-PS000704]; Penn Center for AIDS Research [P30-AI045008]; Penn Mental Health AIDS Research Center [P30-MH097488] FX This project was supported by U18-PS000704 (M. B. Blank, PI) "Multi-Site Rapid HIV Testing in Urban Community Mental Health Settings," by P30-AI045008 (James Hoxie, PI) Penn Center for AIDS Research, and by P30-MH097488 (Dwight Evans, PI) Penn Mental Health AIDS Research Center. NR 64 TC 9 Z9 9 U1 2 U2 4 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 2014 VL 104 IS 12 BP 2377 EP 2384 DI 10.2105/AJPH.2013.301633 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX9GB UT WOS:000347210500046 PM 24524493 ER PT J AU Myers, JE Bodach, S Cutler, BH Shepard, CW Philippou, C Branson, BM AF Myers, Julie E. Bodach, Sara Cutler, Blayne H. Shepard, Colin W. Philippou, Christopher Branson, Bernard M. TI Acceptability of Home Self-Tests for HIV in New York City, 2006 SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID RISK AB Data from a 2006 telephone survey representative of New York City adults showed that more than half (56.2%) of those aged 18 to 64 years responded favorably to a question about acceptability of a rapid home HIV test. More than two thirds of certain subpopulations at high risk for HIV reported that they would use a rapid home HIV test, but approximately half who expressed interest had indications of financial hardship. The match of acceptability and HIV risk bodes well for self-testing utility, but cost might impede uptake. C1 [Myers, Julie E.; Bodach, Sara; Cutler, Blayne H.; Shepard, Colin W.] New York City Dept Hlth & Mental Hyg, Bur HIV AIDS Prevent & Control, New York, NY USA. [Myers, Julie E.] Columbia Univ, Dept Med, Med Ctr, Div Infect Dis, New York, NY USA. [Philippou, Christopher] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA. [Branson, Bernard M.] Ctr Dis Control & Prevent, Natl Ctr HIV Viral Hepatitis STD & TB Prevent, Atlanta, GA USA. RP Myers, JE (reprint author), 42-09 28th St,22-76, Queens, NY 11101 USA. EM jmyers@health.nyc.gov FU New York City Department of Health and Mental Hygiene; Centers for Disease Control and Prevention for HIV prevention [12-1201] FX This work was supported in part by the New York City Department of Health and Mental Hygiene and by a cooperative agreement from the Centers for Disease Control and Prevention for HIV prevention (12-1201). NR 9 TC 5 Z9 5 U1 1 U2 10 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 2014 VL 104 IS 12 BP E46 EP E48 DI 10.2105/AJPH.2014.302271 PG 3 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA AX9GB UT WOS:000347210500014 PM 25320885 ER PT J AU Simeone, RM Oster, ME Cassell, CH Armour, BS Gray, DT Honein, MA AF Simeone, Regina M. Oster, Matthew E. Cassell, Cynthia H. Armour, Brian S. Gray, Darryl T. Honein, Margaret A. TI Pediatric Inpatient Hospital Resource Use for Congenital Heart Defects SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY LA English DT Article DE heart defects; congenital; healthcare resource use; hospital costs; Kids' Inpatient Database ID UNITED-STATES; DISEASE; PREVALENCE; INFANTS; QUALITY; TRENDS; COSTS; CARE AB Background: Congenital heart defects (CHDs) occur in approximately 8 per 1000 live births. Improvements in detection and treatment have increased survival. Few national estimates of the healthcare costs for infants, children and adolescents with CHDs are available. Methods: We estimated hospital costs for hospitalizations using pediatric (0-20 years) hospital discharge data from the 2009 Healthcare Cost and Utilization Project Kids' Inpatient Database (KID) for hospitalizations with CHD diagnoses. Estimates were up-weighted to be nationally representative. Mean costs were compared by demographic factors and presence of critical CHDs (CCHDs). Results: Up-weighting of the KID generated an estimated 4,461,615 pediatric hospitalizations nationwide, excluding normal newborn births. The 163,980 (3.7%) pediatric hospitalizations with CHDs accounted for approximately $5.6 billion in hospital costs, representing 15.1% of costs for all pediatric hospitalizations in 2009. Approximately 17% of CHD hospitalizations had a CCHD, but it varied by age: approximately 14% of hospitalizations of infants, 30% of hospitalizations of patients aged 1 to 10 years, and 25% of hospitalizations of patients aged 11 to 20 years. Mean costs of CHD hospitalizations were higher in infancy ($36,601) than at older ages and were higher for hospitalizations with a CCHD diagnosis ($52,899). Hospitalizations with CCHDs accounted for 26.7% of all costs for CHD hospitalizations, with hypoplastic left heart syndrome, coarctation of the aorta, and tetralogy of Fallot having the highest total costs. Conclusion: Hospitalizations for children with CHDs have disproportionately high hospital costs compared with other pediatric hospitalizations, and the 17% of hospitalizations with CCHD diagnoses accounted for 27% of CHD hospital costs. Birth Defects Research (Part A) 100:934-943, 2014. (c) 2014 Wiley Periodicals, Inc. C1 [Simeone, Regina M.; Oster, Matthew E.; Cassell, Cynthia H.; Armour, Brian S.; Honein, Margaret A.] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA. [Simeone, Regina M.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Oster, Matthew E.] Childrens Healthcare Atlanta, Sibley Heart Ctr, Atlanta, GA USA. [Gray, Darryl T.] Agcy Healthcare Res & Qual, Ctr Qual Improvement, Rockville, MD USA. RP Simeone, RM (reprint author), Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, 1600 Clifton Rd,MS E-86, Atlanta, GA 30333 USA. EM rsimeone@cdc.gov FU Research Participation Program at the Centers for Disease Control and Prevention FX Regina M. Simeone was supported in part by an appointment to the Research Participation Program at the Centers for Disease Control and Prevention administered by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy and the Centers for Disease Control and Prevention. NR 27 TC 11 Z9 11 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1542-0752 EI 1542-0760 J9 BIRTH DEFECTS RES A JI Birth Defects Res. Part A-Clin. Mol. Teratol. PD DEC PY 2014 VL 100 IS 12 BP 934 EP 943 DI 10.1002/bdra.23262 PG 10 WC Developmental Biology; Toxicology SC Developmental Biology; Toxicology GA AX4RB UT WOS:000346918000004 PM 24975483 ER PT J AU Hilty, M Wuthrich, D Salter, SJ Engel, H Campbell, S Sa-Leao, R de Lencastre, H Hermans, P Sadowy, E Turner, P Chewapreecha, C Diggle, M Pluschke, G McGee, L Eser, OK Low, DE Smith-Vaughan, H Endimiani, A Kuffer, M Dupasquier, M Beaudoing, E Weber, J Bruggmann, R Hanage, WP Parkhill, J Hathaway, LJ Muhlemann, K Bentley, SD AF Hilty, Markus Wuethrich, Daniel Salter, Susannah J. Engel, Hansjuerg Campbell, Samuel Sa-Leao, Raquel de Lencastre, Herminia Hermans, Peter Sadowy, Ewa Turner, Paul Chewapreecha, Claire Diggle, Mathew Pluschke, Gerd McGee, Lesley Eser, Ozgen Koseoglu Low, Donald E. Smith-Vaughan, Heidi Endimiani, Andrea Kueffer, Marianne Dupasquier, Melanie Beaudoing, Emmanuel Weber, Johann Bruggmann, Remy Hanage, William P. Parkhill, Julian Hathaway, Lucy J. Muehlemann, Kathrin Bentley, Stephen D. TI Global Phylogenomic Analysis of Nonencapsulated Streptococcus pneumoniae Reveals a Deep-Branching Classic Lineage That Is Distinct from Multiple Sporadic Lineages SO GENOME BIOLOGY AND EVOLUTION LA English DT Article DE pneumococcal isolates; whole-genome sequencing; comparative genomics; integrative conjugative elements; antibiotic nonsusceptibility ID NASOPHARYNGEAL COLONIZATION; CONJUGATIVE ELEMENTS; RESISTANCE; PNEUMOCOCCI; GENE; CONJUNCTIVITIS; EVOLUTION; DISEASE; CLONE; IDENTIFICATION AB The surrounding capsule of Streptococcus pneumoniae has been identified as a major virulence factor and is targeted by pneumococcal conjugate vaccines (PCV). However, nonencapsulated S. pneumoniae (non-Ec-Sp) have also been isolated globally, mainly in carriage studies. It is unknown if non-Ec-Sp evolve sporadically, if they have high antibiotic nonsusceptiblity rates and a unique, specific gene content. Here, whole-genome sequencing of 131 non-Ec-Sp isolates sourced from 17 different locations around the world was performed. Results revealed a deep-branching classic lineage that is distinct from multiple sporadic lineages. The sporadic lineages clustered with a previously sequenced, global collection of encapsulated S. pneumoniae (Ec-Sp) isolates while the classic lineage is comprised mainly of the frequently identified multilocus sequences types (STs) ST344 (n = 39) and ST448 (n= 40). All ST344 and nine ST448 isolates had high nonsusceptiblity rates to beta-lactams and other antimicrobials. Analysis of the accessory genome reveals that the classic non-Ec-Sp contained an increased number of mobile elements, than Ec-Sp and sporadic non-Ec-Sp. Performing adherence assays to human epithelial cells for selected classic and sporadic non-Ec-Sp revealed that the presence of a integrative conjugative element (ICE) results in increased adherence to humanepithelial cells (P= 0.005). Incontrast, sporadic non-EcSp lacking the ICE had greater growth in vitro possibly resulting in improved fitness. In conclusion, non-Ec-Sp isolates from the classic lineage have evolved separately. They have spread globally, are well adapted to nasopharyngeal carriage and are able to coexist with Ec-Sp. Due to continued use of PCV, non-Ec-Sp may become more prevalent. C1 [Hilty, Markus; Engel, Hansjuerg; Campbell, Samuel; Endimiani, Andrea; Kueffer, Marianne; Hathaway, Lucy J.; Muehlemann, Kathrin] Univ Bern, Inst Infect Dis, CH-3012 Bern, Switzerland. [Hilty, Markus; Muehlemann, Kathrin] Univ Hosp Bern, Inselspital, Dept Infect Dis, Bern, Switzerland. [Hilty, Markus; Muehlemann, Kathrin] Univ Bern, CH-3012 Bern, Switzerland. [Wuethrich, Daniel; Bruggmann, Remy] Univ Bern, Interfac Bioinformat Unit, CH-3012 Bern, Switzerland. [Wuethrich, Daniel; Bruggmann, Remy] Swiss Inst Bioinformat, Lausanne, Switzerland. [Salter, Susannah J.; Chewapreecha, Claire; Parkhill, Julian; Bentley, Stephen D.] Wellcome Trust Sanger Inst, Hinxton, Cambs, England. [Sa-Leao, Raquel; de Lencastre, Herminia] Univ Lisbon, Inst Tecnol Quim & Biol, P-1699 Lisbon, Portugal. [de Lencastre, Herminia] Rockefeller Univ, Lab Microbiol & Infect Dis, New York, NY USA. [Hermans, Peter] Radboud Univ Nijmegen, Med Ctr, Lab Pediat Infect Dis, Nijmegen, Netherlands. [Sadowy, Ewa] Natl Med Inst, Warsaw, Poland. [Turner, Paul; Chewapreecha, Claire] Mahidol Univ, Fac Trop Med, Shoklo Malaria Res Unit, Mahidol Oxford Trop Med Res Unit, Mae Sot, Thailand. [Turner, Paul] Univ Oxford, Nuffield Dept Med, Ctr Trop Med, Oxford OX1 2JD, England. [Diggle, Mathew] Queens Med Ctr, Dept Clin Microbiol, Nottingham NG7 2UH, England. [Pluschke, Gerd] Univ Basel, Swiss Trop & Publ Hlth Inst, CH-4003 Basel, Switzerland. [McGee, Lesley] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA USA. [Eser, Ozgen Koseoglu] Hacettepe Univ, Fac Med, Dept Microbiol, Ankara, Turkey. [Low, Donald E.] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada. [Low, Donald E.] Publ Hlth Labs, Toronto, ON, Canada. [Smith-Vaughan, Heidi] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT 0909, Australia. [Dupasquier, Melanie; Beaudoing, Emmanuel; Weber, Johann] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland. [Hanage, William P.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Ctr Communicable Dis Dynam, Cambridge, MA 02138 USA. [Bentley, Stephen D.] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 1TN, England. RP Hilty, M (reprint author), Univ Bern, Inst Infect Dis, CH-3012 Bern, Switzerland. EM markus.hilty@ifik.unibe.ch RI Sa-Leao, Raquel/A-9341-2011; Hermans, Peter/H-8042-2014; Parkhill, Julian/G-4703-2011; ESER, OZGEN/I-8367-2013; OI Sa-Leao, Raquel/0000-0001-9804-827X; Parkhill, Julian/0000-0002-7069-5958; Hilty, Markus/0000-0002-2418-6474; Chewapreecha, Kamolchanok Claire/0000-0002-1313-4011; Turner, Paul/0000-0002-1013-7815; Endimiani, Andrea/0000-0003-3186-5421 FU Swiss National Science Foundation [31003A_133157/1]; Wellcome Trust Clinical Research Training Fellowship [083735/Z/07]; Cambridge BRC; National Institutes of Health [R01 AI106786-01]; Loterie Romande through the Fondation pour la Recherche en Medecine Genetique; PATH; [098051] FX This work was partly funded by a grant from the Swiss National Science Foundation [31003A_133157/1] awarded to K.M. and currently led by L.J.H. Work at the Wellcome Trust Sanger Institute was funded by core grant no. 098051. P.T. was funded by a Wellcome Trust Clinical Research Training Fellowship, grant no 083735/Z/07. S.D.B. is also supported by the Cambridge BRC. W.P.H. was funded by the National Institutes of Health under Award Number R01 AI106786-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The purchase of the PacBio RSII instrument was funded in part by the Loterie Romande through the Fondation pour la Recherche en Medecine Genetique. The authors wish to thank the CDC Arctic Investigations Program for providing the Alaska isolates for this analysis. Isolates contributed by L.M. were from the Pneumococcal Global Strain Bank, a project funded by PATH. The authors thank Suzanne Aebi for excellent technical assistance. NR 43 TC 8 Z9 9 U1 0 U2 7 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1759-6653 J9 GENOME BIOL EVOL JI Genome Biol. Evol. PD DEC PY 2014 VL 6 IS 12 BP 3281 EP 3294 DI 10.1093/gbe/evu263 PG 14 WC Evolutionary Biology; Genetics & Heredity SC Evolutionary Biology; Genetics & Heredity GA AX5YO UT WOS:000347000800012 PM 25480686 ER PT J AU Gilmore, RD Brandt, KS Hyde, JA AF Gilmore, Robert D. Brandt, Kevin S. Hyde, Jenny A. TI pncA and bptA Are Not Sufficient To Complement Ixodes scapularis Colonization and Persistence by Borrelia burgdorferi in a Linear Plasmid lp25-Deficient Background SO INFECTION AND IMMUNITY LA English DT Article ID LYME-DISEASE SPIROCHETE; OUTER SURFACE-PROTEINS; GENE-EXPRESSION; MAMMALIAN HOST; EXPERIMENTAL-INFECTION; TICK VECTOR; IDENTIFICATION; GENOME; ALTERS; BBK32 AB The complex segmented genome of Borrelia burgdorferi is comprised of a linear chromosome along with numerous linear and circular plasmids essential for tick and/or mammalian infectivity. The pathogenic necessity for specific borrelial plasmids has been identified; most notably, infections of the tick vector and mammalian host both require linear plasmid 25 (lp25). Genes carried on lp25, specifically bptA and pncA, are postulated to play a role for B. burgdorferi to infect and persist in Ixodes ticks. In this study, we complemented an lp25-deficient borrelial strain with pncA alone or pncA accompanied by bptA to evaluate the ability of the complemented strains to restore larval colonization and persistence through transstadial transmission relative to that of wild-type B. burgdorferi. The acquisition of the complemented strains by tick larvae from infected mice and/or the survival of these strains was significantly decreased when assayed by cultivation and quantitative PCR (qPCR). Only 10% of the pncA-complemented strain organisms were found by culture to survive 17 days following larval feeding, while 45% of the pncA- and bptA-complemented strain organisms survived, with similar results by PCR. However, neither of the complemented B. burgdorferi strains was capable of persisting through the molt to the nymphal stage as analyzed by culture. qPCR analyses of un-fed nymphs detected B. burgdorferi genomes in several nymphs at low copy numbers, likely indicating the presence of DNA from dead or dying cells. Overall, the data indicate that pncA and bptA cannot independently support infection, suggesting that lp25 carries additional gene(s) or regulatory elements critical for B. burgdorferi survival and pathogenesis in the Ixodes vector. C1 [Gilmore, Robert D.; Brandt, Kevin S.] Natl Ctr Emerging & Zoonot Infect Dis, Ctr Dis Control & Prevent, Div Vector Borne Dis, Colorado Springs, CO USA. [Hyde, Jenny A.] Texas A& M Hlth Sci Ctr, Coll Med, Dept Microbial Pathogenesis & Immunol, College Stn, TX USA. RP Hyde, JA (reprint author), Natl Ctr Emerging & Zoonot Infect Dis, Ctr Dis Control & Prevent, Div Vector Borne Dis, Colorado Springs, CO USA. EM jshyde@medicine.tamhsc.edu FU PHS [AI103627, AI101740] FX Work in the Hyde lab is funded by PHS grants AI103627 and AI101740. NR 44 TC 1 Z9 1 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 2014 VL 82 IS 12 BP 5110 EP 5116 DI 10.1128/IAI.02613-14 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA AX5HZ UT WOS:000346958400021 PM 25245809 ER PT J AU Koul, PA Bali, NK Ali, S Ahmad, SJ Bhat, MA Mir, H Alcram, S Khan, UH AF Koul, Parvaiz A. Bali, Nargis K. Ali, Saima Ahmad, Syed J. Bhat, Muneer A. Mir, Hyder Alcram, Shabir Khan, Umar H. TI Poor uptake of influenza vaccination in pregnancy in northern India SO INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS LA English DT Article DE Influenza; Pregnancy; Vaccination ID WOMEN; INFECTION; SAFETY; IMMUNIZATION; INFANTS; VIRUS; RISK AB Objective: To study the uptake of influenza vaccination among pregnant women in northern India and physicians' beliefs and practices regarding vaccination. Methods: A questionnaire-based survey was undertaken between October 2012 and April 2013. Pregnant women attending an obstetric hospital in Srinagar, India, and healthcare personnel were asked to participate. Results: Among 1000 women aged 18-41 years (13.6% first trimester, 26.8% second trimester), none had been offered or received influenza vaccination. Only 9 (10.0%) of 90 obstetricians surveyed had been vaccinated for influenza in the past 5 years, although 81 (90.0%) believed that influenza could have severe consequences for themselves and their patients. The reasons cited for non-vaccination included poor knowledge about availability of vaccine and concerns about its efficacy. Sixty-six (73.3%) obstetricians believed that vaccine adverse effects are under-reported, and 79 (87.8%) believed that vaccination programs are motivated by profit. Eighty-four (93.3%) obstetricians wished to undergo vaccination in the coming flu season. Conclusion: Influenza vaccination among pregnant women in northern India is nonexistent. Poor uptake is rooted in misperceptions about vaccine availability, efficacy, and safety among treating physicians, few of whom are vaccinated. (C) 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. C1 [Koul, Parvaiz A.; Khan, Umar H.] Sherikashmir Inst Med Sci, Dept Internal & Pulm Med, Srinagar 190011, Jammu & Kashmir, India. [Bali, Nargis K.] Sherikashmir Inst Med Sci, Dept Microbiol, Srinagar 190011, Jammu & Kashmir, India. [Ali, Saima; Ahmad, Syed J.; Bhat, Muneer A.; Mir, Hyder; Alcram, Shabir] US Ctr Dis Control & Prevent, Influenza Surveillance Project, Atlanta, GA USA. [Ali, Saima; Ahmad, Syed J.; Bhat, Muneer A.; Mir, Hyder; Alcram, Shabir] Indian Council Med Res, New Delhi, India. RP Koul, PA (reprint author), Sherikashmir Inst Med Sci, Dept Internal & Pulm Med, Srinagar 190011, Jammu & Kashmir, India. EM parvaizk@gmail.com OI Koul, Parvaiz/0000-0002-1700-9285 FU Sher-i-Kashmir Institute of Medical Sciences, Srinagar FX The authors acknowledge the financial support of the Sher-i-Kashmir Institute of Medical Sciences, Srinagar. NR 28 TC 5 Z9 5 U1 0 U2 4 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0020-7292 EI 1879-3479 J9 INT J GYNECOL OBSTET JI Int. J. Gynecol. Obstet. PD DEC PY 2014 VL 127 IS 3 BP 234 EP 237 DI 10.1016/j.ijgo.2014.05.021 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AX7ZI UT WOS:000347129700003 PM 25085688 ER PT J AU Gerberry, DJ Wagner, BG Garcia-Lerma, JG Heneine, W Blower, S AF Gerberry, David J. Wagner, Bradley G. Garcia-Lerma, J. Gerardo Heneine, Walid Blower, Sally TI Using geospatial modelling to optimize the rollout of antiretroviral-based pre-exposure HIV interventions in Sub-Saharan Africa SO NATURE COMMUNICATIONS LA English DT Article ID SEXUALLY-TRANSMITTED INFECTION; HUMAN-IMMUNODEFICIENCY-VIRUS; COST-EFFECTIVENESS; UNCERTAINTY ANALYSIS; INTRAVAGINAL RING; PROTECTS MACAQUES; GENITAL HERPES; PREVENTION; PROPHYLAXIS; IMPACT AB Antiretroviral (ARV)-based pre-exposure HIV interventions may soon be rolled out in resource-constrained Sub-Saharan African countries, but rollout plans have yet to be designed. Here we use geospatial modelling and optimization techniques to compare two rollout plans for ARV-based microbicides in South Africa: a utilitarian plan that minimizes incidence by using geographic targeting, and an egalitarian plan that maximizes geographic equity in access to interventions. We find significant geographic variation in the efficiency of interventions in reducing HIV transmission, and that efficiency increases disproportionately with increasing incidence. The utilitarian plan would result in considerable geographic inequity in access to interventions, but (by exploiting geographic variation in incidence) could prevent similar to 40% more infections than the egalitarian plan. Our results show that the geographic resource allocation decisions made at the beginning of a rollout, and the location where the rollout is initiated, will be crucial in determining the success of interventions in reducing HIV epidemics. C1 [Gerberry, David J.; Wagner, Bradley G.; Blower, Sally] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Ctr Biomed Modeling, Los Angeles, CA 90024 USA. [Garcia-Lerma, J. Gerardo; Heneine, Walid] Ctr Dis Control & Prevent, Branch Lab, Div HIV AIDS Prevent, Atlanta, GA 30329 USA. RP Blower, S (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Human Behav, Ctr Biomed Modeling, Los Angeles, CA 90024 USA. EM sblower@mednet.ucla.edu RI Barley, Kamal/F-9579-2011 OI Barley, Kamal/0000-0003-1874-9813 FU National Institute of Allergy and Infectious Diseases, National Institutes of Health [R01 AI041935] FX We acknowledge the financial support of the National Institute of Allergy and Infectious Diseases, National Institutes of Health (Grant R01 AI041935). We are grateful to Brian Coburn for his suggestions that improved this work. NR 40 TC 8 Z9 8 U1 1 U2 3 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 2041-1723 J9 NAT COMMUN JI Nat. Commun. PD DEC PY 2014 VL 5 AR 5454 DI 10.1038/ncomms6454 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA AX9KL UT WOS:000347221700001 PM 25462707 ER PT J AU Evans, SF Kobrosly, RW Barrett, ES Thurston, SW Calafat, AM Weiss, B Stahlhut, R Yolton, K Swan, SH AF Evans, Sarah F. Kobrosly, Roni W. Barrett, Emily S. Thurston, Sally W. Calafat, Antonia M. Weiss, Bernard Stahlhut, Richard Yolton, Kimberly Swan, Shanna H. TI Prenatal bisphenol A exposure and maternally reported behavior in boys and girls SO NEUROTOXICOLOGY LA English DT Article DE Bisphenol A; Child behavior problems; Children; Epidemiology ID SEXUAL-DIFFERENTIATION; HEALTH OUTCOMES; GENE-EXPRESSION; PREGNANT-WOMEN; HUMAN BRAIN; URINARY; CHILDREN; CHILDHOOD; VARIABILITY; COHORT AB Prenatal exposure to gonadal hormones plays a major role in the normal development of the male and female brain and sexually dimorphic behaviors. Hormone-dependent differences in brain structure and function suggest that exposure to exogenous endocrine disrupting chemicals may be associated with sex-specific alterations in behavior. Bisphenol A (BPA) is an environmental chemical that has been shown to alter estrogen, androgen, and thyroid hormone signaling pathways. Epidemiological and experimental studies suggest associations between prenatal exposure to BPA and child behavior, however data are inconsistent, and few studies have examined school age children. We examined BPA concentration in spot urine samples from women at mean 27 weeks of pregnancy in relation to child behavior assessed at age 6-10 years using the parent-completed Child Behavior Checklist (CBCL). We report associations between maternal BPA urinary concentrations and several CBCL scores in 153 children (77 boys and 76 girls). We observed a significant interaction between maternal urinary BPA and sex for several behaviors (externalizing, aggression, Anxiety Disorder, Oppositional/Defiant Disorder and Conduct Disorder traits), but no significant associations between BPA and scores on any CBCL scales. However in analyses restricted to children of mothers with detectable prenatal urinary BPA (n = 125), BPA was associated with moderately increased internalizing and externalizing behaviors, withdrawn/depressed behavior, somatic problems, and Oppositional/Defiant Disorder traits in boys. In addition we observed a significant interaction between BPA and sex for several behaviors (externalizing, withdrawn/depressed, rule-breaking, Oppositional/Defiant Disorder traits, and Conduct Disorder traits). These results suggest that prenatal exposure to BPA may be related to increased behavior problems in school age boys, but not girls. (C) 2014 Elsevier Inc. All rights reserved. C1 [Evans, Sarah F.; Kobrosly, Roni W.; Swan, Shanna H.] Mt Sinai Sch Med, Dept Prevent Med, New York, NY 10029 USA. [Barrett, Emily S.; Stahlhut, Richard] Univ Rochester, Sch Med & Dent, Dept Obstet & Gynecol, Rochester, NY 14642 USA. [Thurston, Sally W.] Univ Rochester, Sch Med & Dent, Dept Biostat & Computat Biol, Rochester, NY USA. [Calafat, Antonia M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Environm Hlth Lab Sci, Atlanta, GA USA. [Weiss, Bernard] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY USA. [Yolton, Kimberly] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA. RP Evans, SF (reprint author), Mt Sinai Sch Med, Dept Prevent Med, One Gustave L Levy Pl,Box 1057, New York, NY 10029 USA. EM sarah.evans@mssm.edu FU U.S. Environmental Protection Agency; National Institutes of Health [5T32HD049311, R01-ES09916, MO1-RR00400, MO1-RR0425, K12 ES019852]; BPA GO Grant [1 RC2 ES018736-01]; BPA GO Grant Supplement [1 RC2 ES018736-01S1]; State of Iowa [18018278]; National Center for Advancing Translational Sciences (NCATS) [UL1 TR000042, KL2 TR000095, TL1 TR000096] FX This study was supported by grants from the U.S. Environmental Protection Agency and the National Institutes of Health (5T32HD049311 to Icahn School of Medicine at Mount Sinai, R01-ES09916 to the University of Missouri, MO1-RR00400 to the University of Minnesota, MO1-RR0425 to Harbor-UCLA Medical Center, K12 ES019852 and BPA GO Grant (1 RC2 ES018736-01) and BPA GO Grant Supplement (1 RC2 ES018736-01S1) to the University of Rochester School of Medicine and Dentistry) and by grant 18018278 from the State of Iowa to the University of Iowa. It was also supported by UL1 TR000042, KL2 TR000095, and TL1 TR000096 from the National Center for Advancing Translational Sciences (NCATS), a component of the. The authors thank Xiaoyun Ye, Tao Jia, Xiaoliu Zhou, and Amber Bishop (CDC, Atlanta, GA) for measuring the urinary concentrations of BPA. NR 69 TC 25 Z9 26 U1 0 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X EI 1872-9711 J9 NEUROTOXICOLOGY JI Neurotoxicology PD DEC PY 2014 VL 45 BP 91 EP 99 DI 10.1016/j.neuro.2014.10.003 PG 9 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA AX5GQ UT WOS:000346955100010 PM 25307304 ER PT J AU Ichimori, K King, JD Engels, D Yajima, A Mikhailov, A Lammie, P Ottesen, EA AF Ichimori, Kazuyo King, Jonathan D. Engels, Dirk Yajima, Aya Mikhailov, Alexei Lammie, Patrick Ottesen, Eric A. TI Global Programme to Eliminate Lymphatic Filariasis: The Processes Underlying Programme Success SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID NEGLECTED TROPICAL DISEASES; PAPUA-NEW-GUINEA; INTEGRATED IMPLEMENTATION; WUCHERERIA-BANCROFTI; NATIONAL SCALE; END-POINTS; BED NETS; TRANSMISSION; SURVEILLANCE; HYDROCELE C1 [Ichimori, Kazuyo; King, Jonathan D.; Engels, Dirk; Yajima, Aya; Mikhailov, Alexei] WHO, Dept Control Neglected Trop Dis, CH-1211 Geneva, Switzerland. [Lammie, Patrick] Ctr Dis Control & Prevent, Div Parasite Dis & Malaria, Atlanta, GA USA. [Lammie, Patrick; Ottesen, Eric A.] Task Force Global Hlth, Neglected Trop Dis Support Ctr, Decatur, GA USA. [Ottesen, Eric A.] RTI Int, Washington, DC USA. RP Ichimori, K (reprint author), WHO, Dept Control Neglected Trop Dis, CH-1211 Geneva, Switzerland. EM kingj@who.int FU World Health Organization [001] NR 48 TC 19 Z9 19 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2014 VL 8 IS 12 AR e3328 DI 10.1371/journal.pntd.0003328 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA AX1IM UT WOS:000346701000020 PM 25502758 ER PT J AU Beer, L Skarbinski, J AF Beer, Linda Skarbinski, Jacek TI ADHERENCE TO ANTIRETRO VIRAL THERAPY AMONG HIV-INFECTED ADULTS IN THE UNITED STATES SO AIDS EDUCATION AND PREVENTION LA English DT Article ID MEDICATION ADHERENCE; CARE; PREVENTION; DEPRESSION; RECOMMENDATIONS; INTERVENTIONS; BELIEFS; PEOPLE; ART AB National estimates of antiretroviral therapy (ART) adherence and adherence support services utilization are needed to inform efforts to improve the health of HIV-infected persons in the United States. In a nationally representative sample of HIV-infected adults receiving medical care, 86% self-reported taking all ART doses in the past 72 hours. Overall, 20% reported using adherence support services and 2% reported an unmet need for services. If all nonadherent persons not receiving adherence support and all persons with a self-perceived unmet need for adherence support accessed services, resources to support 42,673 additional persons would be needed. Factors associated with lower adherence included younger age, female gender, depression, stimulant use, binge alcohol use, greater than once-daily dosing, longer time since HIV diagnosis, and patient beliefs. Predictors of adherence are multifactorial so multiple targeted strategies to improve adherence are warranted. Providing adherence support services to all those in need may require additional resources. C1 [Beer, Linda; Skarbinski, Jacek] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA. RP Beer, L (reprint author), Ctr Dis Control & Prevent, Clin Outcomes Team, Behav & Clin Surveillance Branch, Div HIV AIDS Prevent, 1600 Clifton Rd NE,MS E46, Atlanta, GA 30329 USA. EM LBeer@cdc.gov FU Intramural CDC HHS [CC999999] NR 36 TC 10 Z9 10 U1 1 U2 6 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0899-9546 EI 1943-2755 J9 AIDS EDUC PREV JI Aids Educ. Prev. PD DEC PY 2014 VL 26 IS 6 BP 521 EP 537 PG 17 WC Education & Educational Research; Public, Environmental & Occupational Health SC Education & Educational Research; Public, Environmental & Occupational Health GA AX4BM UT WOS:000346879100003 PM 25490733 ER PT J AU Chhabra, P Samoilovich, E Yermalovich, M Chernyshova, L Gheorghita, S Cojocaru, R Shugayev, N Sahakyan, G Lashkarashvili, M Chubinidze, M Zakhashvili, K Videbaek, D Wasley, A Vinje, J AF Chhabra, Preeti Samoilovich, Elena Yermalovich, Marina Chernyshova, Liudmyla Gheorghita, Stela Cojocaru, Radu Shugayev, Nazim Sahakyan, Gayane Lashkarashvili, Marina Chubinidze, Marina Zakhashvili, Khatuna Videbaek, Dovile Wasley, Annemarie Vinje, Jan TI Viral gastroenteritis in rotavirus negative hospitalized children < 5 years of age from the independent states of the former Soviet Union SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Gastroenteritis; Norovirus; Rotavirus; Adenovirus; Astrovirus; Sapovirus ID POLYMERASE CHAIN-REACTION; NOROVIRUS GASTROENTERITIS; SURVEILLANCE NETWORK; ACUTE DIARRHEA; UNITED-STATES; OUTBREAKS; EPIDEMIOLOGY; INFECTIONS; ASTROVIRUS; DIVERSITY AB Purpose: Rotavirus causes nearly 40% of all hospitalizations for AGE among children <5 years of age in the NIS of the former Soviet Union. The etiologic role of other established gastroenteritis viruses in this age group is unknown. Methods: Laboratory-confirmed rotavirus negative fecal specimens (N = 495) collected between January and December 2009 from children in 6 NIS (Armenia, Azerbaijan, Belarus, Georgia, Republic of Moldova and Ukraine) were tested for norovirus, sapovirus, enteric adenovirus and astrovirus by real-time RT-PCR. Genotyping was carried out by sequencing and phylogenetic analysis. Results: Norovirus, enteric adenovirus, sapovirus and astrovirus were detected in 21.8%, 4.0%, 3.2%, and 1.4% of the rotavirus negative specimens, respectively. Mixed infections were identified in 4.1% of the specimens. Phylogenetic analysis showed co-circulation of several different genotypes with GII.4 Den Haag (2006b) norovirus, GI.2 sapovirus, adenovirus type 41, and astrovirus type 1 causing majority of the infections. Conclusion: Norovirus, enteric adenovirus, sapovirus and astrovirus account for a significant proportion (30.5%) of AGE in hospitalized children <5 years of age in 6 NIS. (C) 2014 Elsevier B.V. All rights reserved. C1 [Chhabra, Preeti; Vinje, Jan] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Samoilovich, Elena; Yermalovich, Marina] Republican Res & Pract Ctr Epidemiol & Microbiol, Minist Hlth, Minsk, Byelarus. [Chernyshova, Liudmyla] Natl Acad Postgrad Educ, Dept Pediat Infect Dis & Clin Immunol, Kiev, Ukraine. [Gheorghita, Stela; Cojocaru, Radu] Natl Ctr Publ Hlth, Kishinev, Moldova. [Shugayev, Nazim] Azerbaijan Republican Antiplague Stn, Baku, Azerbaijan. [Sahakyan, Gayane] Natl Ctr Dis Control & Prevent, Minist Hlth, Yerevan, Armenia. [Lashkarashvili, Marina; Chubinidze, Marina; Zakhashvili, Khatuna] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia. [Videbaek, Dovile; Wasley, Annemarie] WHO, Reg Off Europe, DK-2100 Copenhagen, Denmark. RP Chhabra, P (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, 1600 Clifton Rd, Atlanta, GA 30333 USA. EM pchhabra@cdc.gov FU GAVI's FX We would like to thank GAVI's financial support of the sentinel rotavirus surveillance systems and the staff of ministries of health and participating sentinel hospitals who were involved in conducting surveillance. NR 42 TC 5 Z9 5 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2014 VL 28 BP 283 EP 288 DI 10.1016/j.meegid.2014.10.013 PG 6 WC Infectious Diseases SC Infectious Diseases GA AX1YI UT WOS:000346739500043 PM 25460823 ER PT J AU Banyai, K Gentsch, J AF Banyai, Krisztian Gentsch, Jon TI Special issue on 'Genetic diversity and evolution of rotavirus strains: Possible impact of global immunization programs' SO INFECTION GENETICS AND EVOLUTION LA English DT Editorial Material C1 [Banyai, Krisztian] Hungarian Acad Sci, Vet Med Res Inst, Agr Res Ctr, H-1581 Budapest, Hungary. [Gentsch, Jon] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Banyai, K (reprint author), Hungarian Acad Sci, Vet Med Res Inst, Agr Res Ctr, H-1581 Budapest, Hungary. OI Banyai, Krisztian/0000-0002-6270-1772 NR 19 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2014 VL 28 BP 375 EP 376 DI 10.1016/j.meegid.2014.11.015 PG 2 WC Infectious Diseases SC Infectious Diseases GA AX1YI UT WOS:000346739500056 PM 25471676 ER PT J AU Doro, R Laszlo, B Martella, V Leshem, E Gentsch, J Parashar, U Banyai, K AF Doro, Renata Laszlo, Brigitta Martella, Vito Leshem, Eyal Gentsch, Jon Parashar, Umesh Banyai, Krisztian TI Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance: Is there evidence of strain selection from vaccine pressure? SO INFECTION GENETICS AND EVOLUTION LA English DT Review DE Surveillance; Rotarix; RotaTeq; Genotype; Rotavirus ID GROUP-A ROTAVIRUS; DOUBLE-REASSORTANT ROTAVIRUS; IMMUNIZATION PRACTICES ACIP; HOSPITAL-BASED SURVEILLANCE; CHILDREN LESS-THAN-5 YEARS; PORCINE-HUMAN REASSORTANT; GENOME SEQUENCE-ANALYSIS; ACUTE GASTROENTERITIS; MOLECULAR EPIDEMIOLOGY; GENOTYPE DISTRIBUTION AB Comprehensive reviews of pre licensure rotavirus strain prevalence data indicated the global importance of six rotavirus genotypes, G1P[8], G2P[4], G3P[8], G4P[8], G9P[8] and G12P[8]. Since 2006, two vaccines, the monovalent Rotarix (RV1) and the pentavalent RotaTeq (RV5) have been available in over 100 countries worldwide. Of these, 60 countries have already introduced either RV1 or RV5 in their national immunization programs. Post licensure vaccine effectiveness is closely monitored worldwide. This review aimed at describing the global changes in rotavirus strain prevalence over time. The genotype distribution of the nearly 47,000 strains that were characterized during 2007-2012 showed similar picture to that seen in the preceding period. An intriguing finding was the transient predominance of heterotypic strains, mainly in countries using RV1. Unusual and novel antigen combinations continue to emerge, including some causing local outbreaks, even in vaccinated populations. In addition, vaccine strains have been found in both vaccinated infants and their contacts and there is evidence for genetic interaction between vaccine and wild-type strains. In conclusion, the post-vaccine introduction strain prevalence data do not show any consistent pattern indicative of selection pressure resulting from vaccine use, although the increased detection rate of heterotypic G2P[4] strains in some countries following RV1 vaccination is unusual and this issue requires further monitoring. (C) 2014 Elsevier B.V. All rights reserved. C1 [Doro, Renata; Banyai, Krisztian] Hungarian Acad Sci, Agr Res Ctr, Vet Med Res Inst, H-1143 Budapest, Hungary. [Laszlo, Brigitta] Univ Debrecen, Med & Hlth Sci Ctr, Dept Med Microbiol, Debrecen, Hungary. [Martella, Vito] Univ Bari Aldo Moro, Dept Vet Med, Bari, Italy. [Leshem, Eyal; Gentsch, Jon; Parashar, Umesh] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. RP Banyai, K (reprint author), Hungarian Acad Sci, Agr Res Ctr, Vet Med Res Inst, Hungaria Krt 21, H-1143 Budapest, Hungary. EM bkrota@hotmail.com RI Martella, Vito/K-3146-2016; OI Martella, Vito/0000-0002-5740-6947; Leshem, Eyal/0000-0003-1267-6131; Banyai, Krisztian/0000-0002-6270-1772 FU Hungarian Scientific Research Fund (OTKA) [T100727]; Hungarian Academy of Sciences; 'Erdos Pal' scholarship FX K.B. was supported by the Hungarian Scientific Research Fund (OTKA, T100727) and the Momentum program awarded by the Hungarian Academy of Sciences. B.L. was supported by the 'Erdos Pal' scholarship. NR 226 TC 18 Z9 18 U1 4 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2014 VL 28 BP 446 EP 461 DI 10.1016/j.meegid.2014.08.017 PG 16 WC Infectious Diseases SC Infectious Diseases GA AX1YI UT WOS:000346739500064 PM 25224179 ER PT J AU Boula, A Waku-Kouomou, D Kinkela, MN Esona, MD Kemajou, G Mekontso, D Seheri, M Ndze, VN Emah, I Ela, S Dahl, BA Kobela, M Cavallaro, KF Mballa, GAE Genstch, JR Bowen, MD Ndombo, PK AF Boula, Angeline Waku-Kouomou, Diane Kinkela, Mina Njiki Esona, Mathew D. Kemajou, Grace Mekontso, David Seheri, Mapaseka Ndze, Valantine Ngum Emah, Irene Ela, Serge Dahl, Benjamin A. Kobela, Marie Cavallaro, Kathleen F. Mballa, Georges Alain Etoundi Genstch, Jon R. Bowen, Michael D. Ndombo, Paul Koki TI Molecular surveillance of rotavirus strains circulating in Yaounde, Cameroon, September 2007-December 2012 SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Molecular epidemiology; Rotavirus; Surveillance; Cameroon ID GROUP-A ROTAVIRUS; AFRICAN INFANTS; HIGH PREVALENCE; COTE-DIVOIRE; EPIDEMIOLOGY; DIARRHEA; GENOTYPE; IDENTIFICATION; CHILDREN; VACCINE AB Rotavirus is the most common cause of severe diarrheal disease in children under 5 years of age worldwide. The World Health Organization (WHO) estimated that 453,000 rotavirus-attributable deaths occur annually. Through the WHO, the Rotavirus Sentinel Surveillance Program was established in Cameroon in September 2007 with the Mother and Child Center (MCC) in Yaounde playing the role of sentinel site and national laboratory for this program. The objectives of this surveillance were to assess the rotavirus disease burden and collect baseline information on rotavirus strains circulating in Cameroon. Diarrheal stool samples were collected in a pediatric hospital from children under 5, using the WHO case definition for rotavirus diarrhea. Antigen detection of rotavirus was performed by using an enzyme immunoassay (EIA). The genotypic characterization was performed using multiplexed semi-nested reverse transcription-polymerase chain reaction (RT-PCR) assays. Between September 2007 and December 2012, 2444 stool samples were received at the MCC laboratory for rotavirus antigen detection, of which 999 (41%) were EIA positive. Among EIA positive samples 898 were genotyped. Genotype prevalence varied each year. Genotype G9P[8] was the dominant type during 2007 (32%) and 2008 (24%), genotype G3P[6] predominated in 2010 (36%) and 2011 (25%), and G1P[8] was predominant in 2012 (44%). The findings showed that the rotavirus disease burden is high and there is a broad range of rotavirus strains circulating in Yaounde. These data will help measure the impact of vaccination in the future. Published by Elsevier B.V. C1 [Boula, Angeline; Kinkela, Mina Njiki; Kemajou, Grace; Ndze, Valantine Ngum; Ela, Serge; Ndombo, Paul Koki] Chantal Biya Fdn, Mother & Child Ctr, Yaounde, Cameroon. [Waku-Kouomou, Diane; Esona, Mathew D.; Genstch, Jon R.; Bowen, Michael D.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Mekontso, David] World Hlth Org Country Off Cameroon, Yaounde, Cameroon. [Seheri, Mapaseka] Univ Limpopo, MRC, Diarrhoeal Pathogens Res Unit, Sovenga, South Africa. [Emah, Irene; Kobela, Marie] Minist Hlth, Expanded Program Immunizat, Yaounde, Cameroon. [Cavallaro, Kathleen F.] Ctr Dis Control & Prevent, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. [Mballa, Georges Alain Etoundi] Minist Hlth, Direct Dis Control, Yaounde, Cameroon. RP Waku-Kouomou, D (reprint author), Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS C-22, Atlanta, GA 30333 USA. EM irf6@cdc.gov FU Ministry of Health of Cameroon; Bill and Melinda Gates Foundation though the SURVAC Project [51214]; Mother and Child Center, Foundation Chantal Biya; World Health Organization; U.S. Centers for Diseases Control and Prevention; CDC Foundation FX Funding for this work was provided by the Ministry of Health of Cameroon, the Bill and Melinda Gates Foundation though the SURVAC Project (Grant Number 51214), the Mother and Child Center, Foundation Chantal Biya, the World Health Organization, the U.S. Centers for Diseases Control and Prevention, and the CDC Foundation. NR 37 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2014 VL 28 BP 470 EP 475 DI 10.1016/j.meegid.2014.08.019 PG 6 WC Infectious Diseases SC Infectious Diseases GA AX1YI UT WOS:000346739500066 PM 25220619 ER PT J AU Banga-Mingo, V Waku-Kouomou, D Gody, JC Esona, MD Yetimbi, JF Mbary-Daba, R Dahl, BA Dimanche, L Koyazegbe, TD Tricou, V Cavallaro, KF Guifara, G Bowen, MD Gouandjika-Vasilache, I AF Banga-Mingo, Virginie Waku-Kouomou, Diane Gody, Jean Chrysostome Esona, Mathew D. Yetimbi, Jean Fandema Mbary-Daba, Regis Dahl, Benjamin A. Dimanche, Leon Koyazegbe, Thomas d'Aquin Tricou, Vianney Cavallaro, Kathleen F. Guifara, Gilbert Bowen, Michael D. Gouandjika-Vasilache, Ionela TI Molecular surveillance of rotavirus infection in Bangui, Central African Republic, October 2011-September 2013 SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Pediatrics; Rotavirus; Surveillance; Gastroenteritis; Central African Republic ID STRAINS; CHILDREN; VP7; EPIDEMIOLOGY; DIVERSITY; EMERGENCE; DIARRHEA; CONGO AB Background: The World Health Organization (WHO) recommends the introduction of rotavirus vaccine in the immunization program of all countries. In the Central African Republic (CAR), sentinel surveillance for rotavirus gastroenteritis was established in 2011 by the Ministry of Health, with the support of the Surveillance en Afrique Centrale Project (SURVAC). The purpose of this study was to assess the burden of rotavirus gastroenteritis and to identify rotavirus strains circulating in CAR before the introduction of rotavirus vaccine planned for this year, 2014. Methods: One sentinel site and one laboratory at the national level were designated by the CAR Ministry of Health to participate in this surveillance system. Stool samples were collected from children who met the WHO rotavirus gastroenteritis case definition (WHO, 2006). The samples were first screened for group A rotavirus antigen by enzyme immunoassay (EIA), and genotyping assays performed using a multiplex reverse transcriptase PCR (RT-PCR) technique. Results: Between October 2011 and September 2013, 438 stool samples were collected and analyzed for detection of rotavirus antigen; 206 (47%) were positive. Among the 160 (78%) that could be genotyped, G2P[6] was the predominant strain (47%) followed by G1P[8] (25%) and G2P[4] (13%). Conclusions: Almost half of stool samples obtained from children hospitalized with gastroenteritis were positive for rotavirus. These baseline rotavirus surveillance data will be useful to health authorities considering rotavirus vaccine introduction and for evaluating the efficacy of rotavirus vaccine once it is introduced into the routine immunization system. Published by Elsevier B.V. C1 [Banga-Mingo, Virginie; Yetimbi, Jean Fandema; Tricou, Vianney; Gouandjika-Vasilache, Ionela] Inst Pasteur, Bangui, Cent Afr Republ. [Waku-Kouomou, Diane; Esona, Mathew D.; Bowen, Michael D.] US Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Gody, Jean Chrysostome; Dimanche, Leon] Complexe Pediat Bangui, Bangui, Cent Afr Republ. [Mbary-Daba, Regis; Guifara, Gilbert] World Hlth Org Country Off Cent African Republ, Bangui, Cent Afr Republ. [Dahl, Benjamin A.; Cavallaro, Kathleen F.] US Ctr Dis Control & Prevent, Global Immunizat Div, Ctr Global Hlth, Atlanta, GA 30333 USA. [Koyazegbe, Thomas d'Aquin] Programme Elargi Vaccinat, Bangui, Cent Afr Republ. RP Waku-Kouomou, D (reprint author), US Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd NE,MS C-22, Atlanta, GA 30333 USA. EM irf6@cdc.gov OI Tricou, Vianney/0000-0002-5465-8647 FU Ministry of Health of the Central African Republic; Bill and Melinda Gates Foundation though the SURVAC Project [51214]; World Health Organization; U.S. Centers for Diseases Control and Prevention; CDC Foundation; Pasteur Institute of Bangui FX Funding for this work was provided by the Ministry of Health of the Central African Republic, the Bill and Melinda Gates Foundation though the SURVAC Project (Grant No. 51214), the World Health Organization, the U.S. Centers for Diseases Control and Prevention, the CDC Foundation and the Pasteur Institute of Bangui. NR 22 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2014 VL 28 BP 476 EP 479 DI 10.1016/j.meegid.2014.08.023 PG 4 WC Infectious Diseases SC Infectious Diseases GA AX1YI UT WOS:000346739500067 PM 25193563 ER PT J AU Semeiko, GV Yermalovich, MA Poliakova, N Mijatovic-Rustempasic, S Kerin, TK Wasley, A Videbaek, D Gentsch, JR Bowen, MD Samoilovich, EO AF Semeiko, Galina V. Yermalovich, Marina A. Poliakova, Nadezhda Mijatovic-Rustempasic, Slavica Kerin, Tara K. Wasley, Annemarie Videbaek, Dovile Gentsch, Jon R. Bowen, Michael D. Samoilovich, Elena O. TI Rotavirus genotypes in Belarus, 2008-2012 SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Rotavirus; Genotype; VP4; VP7; Belarus ID SURVEILLANCE NETWORK; VACCINATION PROGRAMS; STRAIN SURVEILLANCE; VP4 GENOTYPES; 3-YEAR PERIOD; CHILDREN; DIVERSITY; EUROPE; DIARRHEA; IMPACT AB This study describes group A rotavirus (RVA) genotype prevalence in Belarus from 2008 to 2012. In 2008, data from 3 sites in Belarus (Brest, Mogilev, Minsk) indicated that G4P[8] was the predominant genotype. Data from Minsk (2008-2012) showed that G4P[8] was the predominant RVA genotype in all years except in 2011 when G3P[8] was most frequently detected. Other RVA genotypes common in Europe (G1P[8], G2P[4]) were detected each year of the study. This study reveals the dominance of genotype G4P[8] in Belarus and helps to establish the baseline genotype prevalence prior to RVA vaccine introduction in the country. Published by Elsevier B.V. C1 [Semeiko, Galina V.; Yermalovich, Marina A.; Poliakova, Nadezhda; Samoilovich, Elena O.] Republican Res & Pract Ctr Epidemiol & Microbiol, Minsk, Byelarus. [Mijatovic-Rustempasic, Slavica; Kerin, Tara K.; Gentsch, Jon R.; Bowen, Michael D.] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Wasley, Annemarie; Videbaek, Dovile] World Hlth Org Reg Off Europe, Copenhagen, Denmark. RP Bowen, MD (reprint author), Ctr Dis Control & Prevent, Gastroenteritis & Resp Viruses Lab Branch, DVD, NCIRD, 1600 Clifton Rd NE,Mailstop G04, Atlanta, GA 30333 USA. EM mkb6@cdc.gov FU World Health Organization, Geneva, Switzerland FX We wish to thank Rashi Gautam and Sunando Roy for their critical review of this manuscript. Funding for this study was provided by the World Health Organization, Geneva, Switzerland. NR 31 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2014 VL 28 BP 480 EP 485 DI 10.1016/j.meegid.2014.09.007 PG 6 WC Infectious Diseases SC Infectious Diseases GA AX1YI UT WOS:000346739500068 PM 25218086 ER PT J AU Roy, S Esona, MD Kirkness, EF Akopov, A McAllen, JK Wikswo, ME Cortese, MM Payne, DC Parashar, UD Gentsch, JR Bowen, MD AF Roy, Sunando Esona, Mathew D. Kirkness, Ewen F. Akopov, Asmik McAllen, J. Kyle Wikswo, Mary E. Cortese, Margaret M. Payne, Daniel C. Parashar, Umesh D. Gentsch, Jon R. Bowen, Michael D. CA Natl Rotavirus Strain Surveillance New Vaccine Surveillance Network TI Comparative genomic analysis of genogroup 1 (Wa-like) rotaviruses circulating in the USA, 2006-2009 SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Rotavirus; Vaccine; Failure; Allele; VP4; VP7 ID GROUP-A ROTAVIRUSES; PCR PRIMER DESIGN; VACCINE-INTRODUCTION; INTRAGENIC RECOMBINATION; GENOTYPE DISTRIBUTION; PHYLOGENETIC ANALYSIS; MAXIMUM-LIKELIHOOD; SELECTIVE PRESSURE; PORCINE ROTAVIRUS; GENETIC-ANALYSIS AB Group A rotaviruses (RVA) are double stranded RNA viruses that are a significant cause of acute pediatric gastroenteritis. Beginning in 2006 and 2008, respectively, two vaccines, Rotarix (TM) and RotaTeq (R), have been approved for use in the USA for prevention of RVA disease. The effects of possible vaccine pressure on currently circulating strains in the USA and their genome constellations are still under investigation. In this study we report 33 complete RVA genomes (ORF regions) collected in multiple cities across USA during 2006-2009, including 8 collected from children with verified receipt of 3 doses of rotavirus vaccine. The strains included 16 G1P[8], 10 G3P[8], and 7 G9P[8]. All 33 strains had a Wa like backbone with the consensus genotype constellation of G(1/3/9)-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. From maximum likelihood based phylogenetic analyses, we identified 3-7 allelic constellations grouped mostly by respective G types, suggesting a possible allelic segregation based on the VP7 gene of RVA, primarily for the G3 and G9 strains. The vaccine failure strains showed similar grouping for all genes in G9 strains and most genes of G3 strains suggesting that these constellations were necessary to evade vaccine-derived immune protection. Substitutions in the antigenic region of VP7 and VP4 genes were also observed for the vaccine failure strains which could possibly explain how these strains escape vaccine induced immune response. This study helps elucidate how RVA strains are currently evolving in the population post vaccine introduction and supports the need for continued RVA surveillance. Published by Elsevier B.V. C1 [Roy, Sunando; Esona, Mathew D.; Wikswo, Mary E.; Cortese, Margaret M.; Payne, Daniel C.; Parashar, Umesh D.; Gentsch, Jon R.; Bowen, Michael D.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Div Viral Dis, Atlanta, GA 30333 USA. [Kirkness, Ewen F.; Akopov, Asmik; McAllen, J. Kyle] J Craig Venter Inst, Rockville, MD USA. RP Bowen, MD (reprint author), Ctr Dis Control & Prevent, Gastroenteritis & Resp Viruses Lab Branch, DVD, NCIRD, 1600 Clifton Rd NE,Mailstop G04, Atlanta, GA 30333 USA. EM mkb6@cdc.gov FU National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272200900007C] FX This project has been funded in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under contract number HHSN272200900007C. NR 76 TC 3 Z9 3 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2014 VL 28 BP 513 EP 523 DI 10.1016/j.meegid.2014.09.021 PG 11 WC Infectious Diseases SC Infectious Diseases GA AX1YI UT WOS:000346739500071 PM 25301114 ER PT J AU Tam, KI Roy, S Esona, MD Jones, S Sobers, S Morris-Glasgow, V Rey-Benito, G Gentsch, JR Bowen, MD AF Tam, Ka Ian Roy, Sunando Esona, Mathew D. Jones, Starlene Sobers, Stephanie Morris-Glasgow, Victoria Rey-Benito, Gloria Gentsch, Jon R. Bowen, Michael D. TI Full genomic characterization of a novel genotype combination, G4P[14], of a human rotavirus strain from Barbados SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Rotavirus; Reassortment; P[14]; Human; Porcine ID GROUP-A ROTAVIRUS; MOLECULAR CHARACTERIZATION; PHYLOGENETIC ANALYSIS; VACCINATION PROGRAMS; MAXIMUM-LIKELIHOOD; VP7 GENES; DIVERSITY; PORCINE; GASTROENTERITIS; TRANSMISSION AB Since 2004, the Pan American Health Organization (PAHO) has carried out rotavirus surveillance in Latin America and the Caribbean. Here we report the characterization of human rotavirus with the novel G-P combination of G4P[14], detected through PAHO surveillance in Barbados. Full genome sequencing of strain RVA/Human-wt/BRB/CDC1133/2012/G4P[14] revealed that its genotype is G4-P[14]-I1-R1-C1-M1-A8-N1-T1-E1-H1. The possession of a Genogroup 1 (Wa-like) backbone distinguishes this strain from other P[14] rotavirus strains. Phylogenetic analyses suggested that this strain was likely generated by genetic reassortment between human, porcine and possibly other animal rotavirus strains and identified 7 lineages within the P[14] genotype. The results of this study reinforce the potential role of interspecies transmission in generating human rotavirus diversity through reassortment. Continued surveillance is important to determine if rotavirus vaccines will protect against strains that express the P[14] rotavirus genotype. Published by Elsevier B.V. C1 [Tam, Ka Ian; Roy, Sunando; Esona, Mathew D.; Gentsch, Jon R.; Bowen, Michael D.] Ctr Dis Control & Prevent, Gastroenteritis & Resp Viruses Lab Branch, Div Viral Dis, NCIRD, Atlanta, GA USA. [Jones, Starlene; Sobers, Stephanie] Minist Hlth, Publ Hlth Lab, St Michael, Barbados. [Morris-Glasgow, Victoria] Caribbean Publ Hlth Agcy CARPHA, Port of Spain, Trinid & Tobago. [Rey-Benito, Gloria] Pan Amer Hlth Org, Washington, DC USA. RP Bowen, MD (reprint author), 1600 Clifton Rd NE,Mail Stop G04, Atlanta, GA 30333 USA. EM mkb6@cdc.gov FU Ministry of Health, Barbados; World Health Organization; Pan American Health Organization FX We wish to thank Rashi Gautam and Slavica Mijatovic-Rustempasic for their review of the manuscript and helpful comments. We also wish to thank the Ministry of Health, Barbados, the Pan American Health Organization, and the World Health Organization for their support of this study. NR 51 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2014 VL 28 BP 524 EP 529 DI 10.1016/j.meegid.2014.09.020 PG 6 WC Infectious Diseases SC Infectious Diseases GA AX1YI UT WOS:000346739500072 PM 25251674 ER PT J AU Wu, FT Banyai, K Jiang, BM Wu, CY Chen, HC Feher, E Huang, YC Lin, JS Huang, FC Hsiung, CA Huang, JC Wu, HS AF Wu, Fang-Tzy Banyai, Krisztian Jiang, Baoming Wu, Ching-Yi Chen, Hsieh-Cheng Feher, Eniko Huang, Yhu-Chering Lin, Jen-Shiou Huang, Fu-Chen Hsiung, Chao A. Huang, Jason C. Wu, Ho-Sheng TI Molecular epidemiology of human G2P[4] rotaviruses in Taiwan, 2004-2011 SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Surveillance; Genotype; Phylogenetic analysis; Lineage ID POLYMERASE-CHAIN-REACTION; VACCINE; EVOLUTION; STRAINS; VP7; DS-1-LIKE; ACID AB In 2006, two rotavirus vaccines (Rotarix and RotaTeq) became available on the private market in Taiwan. Although vaccine coverage is currently low, molecular surveillance of rotavirus strains can provide pertinent information for evaluation of the potential impact of vaccine introduction and infection control. During January 2008-December 2011, children aged <5 years hospitalized with acute gastroenteritis were enrolled from sentinel surveillance hospitals in three geographic areas of Taiwan. Fecal specimens collected from enrolled patients were tested for rotavirus by enzyme immunoassay and reverse transcriptase-polymerase chain reaction. For genotyping, gene specific primer sets were used to amplify and sequence the genes encoding the neutralization antigens, VP7 and VP4. The resulting sequences were then subjected to phylogenetic analysis. In brief, a total of 4,052 fecal specimens were tested and 742 (18%) samples were positive for rotavirus. The annual range of rotavirus positive specimens varied between 16% and 20.7%. Of all specimens, genotype G1P[8] (63.3%) was the predominant strain, followed by G2P[4] (12.5%), G3P[8] (11.7%), and G9P[8] (5.1%). Uncommon strains were also detected in low percentages. We observed that the rotavirus positivity rate steadily decreased from 21% to 16% during 20082010, then slightly increased to 20% in 2011, when an increase in the number of G2P[4] cases was observed. Sequence and phylogenetic analysis was carried out to help understand any potential changes of G2P[4] rotaviruses over time. A number of G2P[4] strains collected between 2004 and 2011 were analyzed in detail and our analyses showed marked genetic and antigenic variability in the VP7 and VP4 genes. The Taiwanese strains could be classified into two major G2 VP7 lineages (IV and V) and two major P[4] VP4 lineages (IV and V) and several minor sublineages within lineage IV. Lineage V within both G2 and P[4] represented newly recognized genetic variants of the respective genotypes. The distribution of individual combinations of the G2 and P[4] (sub) lineages showed some temporal variations. This study provides further evidence for the great genetic diversity among G2P[4] strains and helps understand the epidemiological trends of these strains among children in Taiwan. (C) 2014 Elsevier B.V. All rights reserved. C1 [Wu, Fang-Tzy; Wu, Ching-Yi; Chen, Hsieh-Cheng; Wu, Ho-Sheng] Ctr Dis Control, Ctr Res Diagnost & Vaccine Dev, Taipei, Taiwan. [Wu, Fang-Tzy; Huang, Jason C.] Natl Yang Ming Univ, Dept Biotechnol, Taipei 112, Taiwan. [Wu, Fang-Tzy; Huang, Jason C.] Natl Yang Ming Univ, Lab Sci Med, Taipei 112, Taiwan. [Banyai, Krisztian] Hungarian Acad Sci, Vet Med Res Inst, Agr Res Ctr, H-1581 Budapest, Hungary. [Jiang, Baoming] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. [Huang, Yhu-Chering] Chang Gung Univ, Chang Gung Childrens Hosp, Chang Gung Mem Hosp, Dept Pediat,Coll Med, Taoyuan, Taiwan. [Lin, Jen-Shiou] Changhua Christian Hosp, Div Pediat Infect Dis, Changhua, Taiwan. [Lin, Jen-Shiou] Changhua Christian Hosp, Dept Lab Med, Changhua, Taiwan. [Huang, Fu-Chen] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung, Taiwan. [Huang, Fu-Chen] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan. [Hsiung, Chao A.] Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Taiwan. [Huang, Jason C.] Natl Yang Ming Univ, AIDS Prevent & Res Ctr, Taipei 112, Taiwan. RP Huang, JC (reprint author), 161 Kun Yang St, Taipei, Taiwan. EM fang@cdc.gov.tw; jchuang2@ym.edu.tw; wuhs@cdc.gov.tw RI Hsiung, Chao Agnes/E-3994-2010; OI Banyai, Krisztian/0000-0002-6270-1772 FU Centers for Disease Control, Department of Health, Taiwan [DOH98-DC-1005, DOH102-DC-2202, MOHW103-CDC-C-315-000201, MOHW103-CDC-C-315-000801]; Hungarian Scientific Research Fund (OTKA) [T100727]; Momentum program; European Union; State of Hungary; European Social Fund 'National Excellence Program' [TAMOP 4.2.4. A/2-11-1-2012-0001] FX This study was financially supported in part by research grant of DOH98-DC-1005, DOH102-DC-2202, MOHW103-CDC-C-315-000201 and MOHW103-CDC-C-315-000801 from Centers for Disease Control, Department of Health, Taiwan. Krisztian Banyai was supported by the Hungarian Scientific Research Fund (OTKA, T100727) and the Momentum program. Additional support was given to Eniko Feher by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TAMOP 4.2.4. A/2-11-1-2012-0001 'National Excellence Program'. NR 22 TC 5 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2014 VL 28 BP 530 EP 536 DI 10.1016/j.meegid.2014.09.033 PG 7 WC Infectious Diseases SC Infectious Diseases GA AX1YI UT WOS:000346739500073 PM 25281207 ER PT J AU Ndze, VN Esona, MD Achidi, EA Gonsu, KH Doro, R Marton, S Farkas, S Ngeng, MB Ngu, AF Obama-Abena, MT Banyai, K AF Ndze, Valentine Ngum Esona, Mathew Dioh Achidi, Eric Akum Gonsu, Kamga Hortense Doro, Renta Marton, Szilvia Farkas, Szilvia Ngeng, Marxcel Bong Ngu, Akum Felix Obama-Abena, Marie Therese Banyai, Krisztin TI Full genome characterization of human Rotavirus A strains isolated in Cameroon, 2010-2011: Diverse combinations of the G and P genes and lack of reassortment of the backbone genes SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Rotavirus A genomics; Phylogeny; Ion Torrent PGM; Cameroon ID GROUP-A ROTAVIRUS; SEQUENCE-INDEPENDENT AMPLIFICATION; SEROTYPE G12 ROTAVIRUSES; RNA-RNA HYBRIDIZATION; INTERSPECIES TRANSMISSION; MOLECULAR EPIDEMIOLOGY; MONOCLONAL-ANTIBODIES; SURVEILLANCE NETWORK; VACCINATION PROGRAMS; ANIMAL ROTAVIRUSES AB Over the past few years whole genome sequencing of rotaviruses has become a routine laboratory method in many strain surveillance studies. To study the molecular evolutionary pattern of representative Cameroonian Rotavirus A (RVA) strains, the semiconductor sequencing approach was used following random amplification of genomic RNA. In total, 31 RVA strains collected during 2010-2011 in three Cameroonian study sites located 120 to 1240 km from each other were sequenced and analyzed. Sequence analysis of the randomly selected representative strains showed that 18 RVAs were Wa-like, expressing G1P[6], G12P[6], or G12P[8] neutralization antigens on the genotype 1 genomic constellation (I1-R1-C1-M1-A1-N1-T1-E1-H1), whereas 13 other strains were DS-1-like, expressing G2P[4], G2P[6], G3P[6], and G6P[6] on the genotype 2 genomic constellation (I2-R2-C2-M2-A2-N2-T2-E2-H2). No inter-genogroup reassortment in the backbone genes was observed. Phylogenetic analysis of the Cameroonian G6P[6] strains indicated the separation of the strains identified in the Far North region (Maroua) and the Northwest region (Bamenda and Esu) into two branches that is consistent with multiple introductions of G6P[6] strains into this country. The present whole genome based molecular characterization study indicates that the emerging G6P[6] strain is fully heterotypic to Rotarix, the vaccine introduced during 2014 in childhood immunization program in Cameroon. Continuous strain monitoring is therefore needed in this area and elsewhere to see if G6s, besides genotype G1 to G4, G8, G9 and G12, may become a new, regionally important genotype in the post vaccine licensure era in Africa. (C) 2014 Elsevier B.V. All rights reserved. C1 [Ndze, Valentine Ngum; Gonsu, Kamga Hortense; Obama-Abena, Marie Therese] Univ Yaounde I, Fac Med & Biomed Sci, Yaounde, Cameroon. [Esona, Mathew Dioh] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Achidi, Eric Akum] Univ Buea, Fac Sci, Buea, Cameroon. [Doro, Renta; Marton, Szilvia; Farkas, Szilvia; Banyai, Krisztin] Hungarian Acad Sci, Vet Med Res Inst, H-1581 Budapest, Hungary. [Ngeng, Marxcel Bong] Reg Hosp Maroua, Med Diagnost Lab, Maroua, Cameroon. [Ngu, Akum Felix] Reg Hosp Lab Bamenda, Bamenda, Cameroon. RP Ndze, VN (reprint author), Univ Yaounde I, Fac Med & Biomed Sci, Yaounde, Cameroon. EM valentinengum@yahoo.com; bkrota@hotmail.com OI Banyai, Krisztian/0000-0002-6270-1772 FU Hungarian Scientific Research Fund (OTKA) [T100727]; Hungarian Academy of Sciences FX This research was funded by a grant from the Hungarian Scientific Research Fund (OTKA, T100727) and the Momemtum program awarded by the Hungarian Academy of Sciences. Assistance with NGS related bioinformatics is acknowledged to Balazs Horvath. We are also grateful to Anett Horvath, Wilfred Ngwoh Tang, and Zang Magdaleine for the excellent technical assistance. NR 85 TC 13 Z9 13 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2014 VL 28 BP 537 EP 560 DI 10.1016/j.meegid.2014.10.009 PG 24 WC Infectious Diseases SC Infectious Diseases GA AX1YI UT WOS:000346739500074 PM 25460824 ER PT J AU Velasquez, DE Parashar, UD Jiang, BM AF Velasquez, Daniel E. Parashar, Umesh D. Jiang, Baoming TI Strain diversity plays no major role in the varying efficacy of rotavirus vaccines: An overview SO INFECTION GENETICS AND EVOLUTION LA English DT Article DE Rotavirus; Genotypes; Vaccines; Strains; Diarrhea; Efficacy ID 1ST 2 YEARS; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; TETRAVALENT RHESUS-HUMAN; VACCINATION PROGRAMS; HEALTHY INFANTS; YOUNG-CHILDREN; REASSORTANT VACCINE; PROVIDES PROTECTION; ANTIBODY-RESPONSES AB While a monovalent Rotarix (R) [RV1] and a pentavalent RotaTeq (R) [RV5] have been extensively tested and found generally safe and equally efficacious in clinical trials, the question still lingers about the evolving diversity of circulating rotavirus strains over time and their relationship with protective immunity induced by rotavirus vaccines. We reviewed data from clinical trials and observational studies that assessed the efficacy or field effectiveness of rotavirus vaccines against different rotavirus strains worldwide. RV1 provided broad clinical efficacy and field effectiveness against severe diarrhea due to all major circulating strains, including the homotypic G1P[8] and the fully heterotypic G2P[4] strains. Similarly, RV5 provided broad efficacy and effectiveness against RV5 and non-RV5 strains throughout different locations. Rotavirus vaccination provides broad heterotypic protection; however continuing surveillance is needed to track the change of circulating strains and monitor the effectiveness and safety of vaccines. Published by Elsevier B.V. C1 [Velasquez, Daniel E.; Parashar, Umesh D.; Jiang, Baoming] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA. RP Jiang, BM (reprint author), Natl Ctr Immunizat & Resp Dis, MS G04,1600 Clifton Rd NE, Atlanta, GA 30329 USA. EM bxj4@cdc.gov NR 95 TC 14 Z9 14 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1567-1348 EI 1567-7257 J9 INFECT GENET EVOL JI Infect. Genet. Evol. PD DEC PY 2014 VL 28 BP 561 EP 571 DI 10.1016/j.meegid.2014.10.008 PG 11 WC Infectious Diseases SC Infectious Diseases GA AX1YI UT WOS:000346739500075 PM 25460825 ER PT J AU Moonesinghe, R Bouye, K Penman-Aguilar, A AF Moonesinghe, Ramal Bouye, Karen Penman-Aguilar, Ana TI Difference in Health Inequity between Two Population Groups due to a Social Determinant of Health SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Article DE social determinants of health; health inequity; population attributable risk ID EQUITY; DISPARITIES AB The World Health Organization defines social determinants of health as "complex, integrated, and overlapping social structures and economic systems" that are responsible for most health inequities. Similar to the individual-level risk factors such as behavioral and biological risk factors that influence disease, we consider social determinants of health such as the distribution of income, wealth, influence and power as risk factors for risk of disease. We operationally define health inequity in a disease within a population due to a risk factor that is unfair and avoidable as the difference between the disease outcome with and without the risk factor in the population. We derive expressions for difference in health inequity between two populations due to a risk factor that is unfair and avoidable for a given disease. The difference in heath inequity between two population groups due to a risk factor increases with increasing difference in relative risks and the difference in prevalence of the risk factor in the two populations. The difference in health inequity could be larger than the difference in health outcomes between the two populations in some situations. Compared to health disparities which are typically measured and monitored using absolute or relative disparities of health outcomes, the methods presented in this manuscript provide a different, yet complementary, picture because they parse out the contributions of unfair and avoidable risk factors. C1 [Moonesinghe, Ramal; Bouye, Karen; Penman-Aguilar, Ana] Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Equ, Atlanta, GA 30341 USA. RP Moonesinghe, R (reprint author), Ctr Dis Control & Prevent, Off Minor Hlth & Hlth Equ, 4770 Buford Highway,Mailstop K77, Atlanta, GA 30341 USA. EM rmoonesinghe@cdc.gov; keh2@cdc.gov; bpv4@cdc.gov NR 18 TC 3 Z9 3 U1 6 U2 20 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1660-4601 J9 INT J ENV RES PUB HE JI Int. J. Environ. Res. Public Health PD DEC PY 2014 VL 11 IS 12 BP 13074 EP 13083 DI 10.3390/ijerph111213074 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA AX2TJ UT WOS:000346797100062 PM 25522048 ER PT J AU Goldsmith, CS AF Goldsmith, Cynthia S. TI Morphologic Differentiation of Viruses beyond the Family Level SO VIRUSES-BASEL LA English DT Review DE virus; electron microscopy; Poxviridae; Reoviridae; Retroviridae; Herpesviridae; Filoviridae; Bunyaviridae ID ELECTRON-MICROSCOPY; INFECTED CELLS; CLASSIFICATION AB Electron microscopy has been instrumental in the identification of viruses by being able to characterize a virus to the family level. There are a few cases where morphologic or morphogenesis factors can be used to differentiate further, to the genus level. These include viruses in the families Poxviridae, Reoviridae, Retroviridae, Herpesviridae, Filoviridae, and Bunyaviridae. C1 Ctr Dis Control & Prevent CDC, Div High Consequence Pathogens & Pathol, Infect Dis Pathol Branch, Atlanta, GA 30333 USA. RP Goldsmith, CS (reprint author), Ctr Dis Control & Prevent CDC, Div High Consequence Pathogens & Pathol, Infect Dis Pathol Branch, Atlanta, GA 30333 USA. EM cgoldsmith@cdc.gov NR 31 TC 3 Z9 3 U1 1 U2 5 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD DEC PY 2014 VL 6 IS 12 BP 4902 EP 4913 DI 10.3390/v6124902 PG 12 WC Virology SC Virology GA AX3JA UT WOS:000346834500006 PM 25502324 ER PT J AU Callaghan, WM AF Callaghan, William M. TI State-based maternal death reviews: assessing opportunities to alter outcomes SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Editorial Material ID MORTALITY C1 Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA. RP Callaghan, WM (reprint author), Ctr Dis Control & Prevent, Div Reprod Hlth, Atlanta, GA 30333 USA. EM wgc0@cdc.gov FU Intramural CDC HHS [CC999999] NR 19 TC 5 Z9 5 U1 1 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD DEC PY 2014 VL 211 IS 6 BP 581 EP 582 DI 10.1016/j.ajog.2014.07.041 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AW9NW UT WOS:000346585300004 PM 25459561 ER PT J AU Creanga, AA Bateman, BT Mhyre, JM Kuklina, E Shilkrut, A Callaghan, WM AF Creanga, Andreea A. Bateman, Brian T. Mhyre, Jill M. Kuklina, Elena Shilkrut, Alexander Callaghan, William M. TI Performance of racial and ethnic minority-serving hospitals on delivery-related indicators SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE delivery; ethnicity; quality of care; race; United States ID LOW-BIRTH-WEIGHT; MATERNAL MORBIDITY; PRENATAL-CARE; UNITED-STATES; DISPARITIES; HOSPITALIZATIONS; MORTALITY AB OBJECTIVE: We sought to explore how racial/ethnic minority-serving hospitals perform on 15 delivery-related indicators, and examine whether indicators vary by race/ethnicity within the same type of hospitals. STUDY DESIGN: We used 2008 through 2011 linked State Inpatient Database and American Hospital Association data from 7 states, and designated hospitals with >50% of deliveries to non-Hispanic white, non-Hispanic black, and Hispanic women as white-, black-, and Hispanic-serving, respectively. We calculated indicator rates per 1000 deliveries by hospital type and, separately, for non-Hispanic white, non-Hispanic black, and Hispanic women within each hospital type. We fitted multivariate Poisson regression models to examine associations between delivery-related indicators and patient and hospital characteristics by hospital type. RESULTS: White-serving hospitals offer obstetric care to an older and wealthier population than black- or Hispanic-serving hospitals. Rates of the most prevalent indicators examined (complicated vaginal delivery, complicated cesarean delivery, obstetric trauma) were lowest in Hispanic-serving hospitals. Generally, indicator rates were similar in Hispanic- and white-serving hospitals. Black-serving hospitals performed worse than other hospitals on 12 of 15 indicators. Indicator rates varied greatly by race/ethnicity in white- and Hispanic-serving hospitals, with non-Hispanic blacks having 1.19-3.27 and 1.15-2.68 times higher rates than non-Hispanic whites, respectively, for 11 of 15 indicators. Conversely, there were few indicator rate differences by race/ethnicity in black-serving hospitals, suggesting an overall lower performance of these hospitals compared to white- and Hispanic-serving hospitals. CONCLUSION: We found considerable differences in delivery-related indicators by hospital type and patients' race/ethnicity. Obstetric care quality measures are needed to track racial/ethnic disparities at the facility and population levels. C1 [Creanga, Andreea A.; Callaghan, William M.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30333 USA. [Kuklina, Elena] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Heart Dis & Stroke Prevent, Atlanta, GA USA. [Bateman, Brian T.] Brigham & Womens Hosp, Dept Med, Div Pharmacoepidemiol & Pharmacoecon, Boston, MA 02115 USA. [Bateman, Brian T.] Harvard Univ, Sch Med, Boston, MA USA. [Bateman, Brian T.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Anesthesiol Crit Care & Pain Med, Boston, MA USA. [Mhyre, Jill M.] Univ Michigan Hlth Syst, Dept Anesthesiol, Ann Arbor, MI USA. [Shilkrut, Alexander] New York Med Coll, Dept Obstet & Gynecol, Valhalla, NY 10595 USA. RP Creanga, AA (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Reprod Hlth, Atlanta, GA 30333 USA. EM acreanga@cdc.gov OI Shilkrut, Alexander/0000-0001-7596-9770 NR 27 TC 6 Z9 6 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD DEC PY 2014 VL 211 IS 6 AR 647.e1 DI 10.1016/j.ajog.2014.06.006 PG 16 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AW9NW UT WOS:000346585300020 PM 24909341 ER PT J AU England, LJ Anderson, BL Tong, VTK Mahoney, J Coleman-Cowger, VH Melstrom, P Schulkin, J AF England, Lucinda Jane Anderson, Britta Louise Van Thi Ky Tong Mahoney, Jeanne Coleman-Cowger, Victoria Hope Melstrom, Paul Schulkin, Jay TI Screening practices and attitudes of obstetricians-gynecologists toward new and emerging tobacco products SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE electronic cigarette; obstetrician-gynecologist; pregnancy; smokeless tobacco ID PRENATAL NICOTINE EXPOSURE; ELECTRONIC CIGARETTES; PROSPECTIVE COHORT; SMOKING REDUCTION; BIRTH-WEIGHT; GESTATIONAL-AGE; SNUFF USE; PREGNANCY; CESSATION; WOMEN AB OBJECTIVE: We examined screening practices and attitudes of obstetricians-gynecologists toward the use of noncombustible tobacco products (chewing tobacco, snuff/snus, electronic cigarettes, and dissolvables) during pregnancy. STUDY DESIGN: The authors mailed a survey in 2012 to 1024 members of the American College of Obstetricians and Gynecologists, including Collaborative Ambulatory Research Network (CARN) and non-CARN members. Stratified random selection was used to generate CARN and non-CARN samples. RESULTS: Response rates were 52% and 31% for CARN and non-CARN members, respectively. Of 252 total eligible respondents (those currently providing obstetrics care) 53% reported screening pregnant women at intake for noncombustible tobacco product use all or some of the time, and 40% reported none of the time. Respondents who reported that noncombustible products have adverse health effects during pregnancy, but are safer than cigarettes, ranged from 20.2% (dissolvables) to 29% (electronic cigarettes) and that the health effects are the same as those of cigarettes from 13.5% (electronic cigarettes) to 53.6% (chewing tobacco). Approximately 14% reported that electronic cigarettes have no adverse health effects;< 1% reported no health effects for the remaining products. Two-thirds of the respondents wanted to know more about the potential health effects of noncombustible tobacco products; only 5% believed themselves to be fully informed. CONCLUSION: A large proportion of obstetrician-gynecologists reported never or inconsistently screening their pregnant patients for the use of noncombustible tobacco products. Responses regarding the harms of these products relative to cigarettes were mixed and most respondents wanted more information. Development and dissemination of guidance for providers is needed to improve decision-making regarding noncombustible tobacco products. C1 [England, Lucinda Jane; Van Thi Ky Tong; Melstrom, Paul] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. [Anderson, Britta Louise; Mahoney, Jeanne; Schulkin, Jay] Amer Coll Obstetricians & Gynecologists, Washington, DC 20024 USA. [Coleman-Cowger, Victoria Hope] Chestnut Hlth Syst, Normal, IL USA. RP England, LJ (reprint author), Ctr Dis Control & Prevent, 4770 Buford Highway NE MS F-79, Atlanta, GA 30341 USA. EM lbe9@cdc.gov OI Coleman-Cowger, Victoria/0000-0002-7745-7223 FU Maternal and Child Health Research Program, Health Resources and Services Administration, U.S. Department of Health and Human Services [UA6MC19010] FX Supported by grant number UA6MC19010 through the Maternal and Child Health Research Program, Health Resources and Services Administration, U.S. Department of Health and Human Services. NR 51 TC 5 Z9 5 U1 0 U2 7 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD DEC PY 2014 VL 211 IS 6 AR 695.e1 DI 10.1016/j.ajog.2014.05.041 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA AW9NW UT WOS:000346585300038 PM 24881828 ER PT J AU Vinson, C Stevens, L Torode, J Saraiya, M Sutcliffe, S Gospodacrowicz, M Anderson, B Adewole, I Luciani, S AF Vinson, Cynthia Stevens, Lisa Torode, Julie Saraiya, Mona Sutcliffe, Simon Gospodacrowicz, Mary Anderson, Benjamin Adewole, Isaac Luciani, Silvana TI AN INTERNATIONAL PARTNERSHIP TO ALIGN CANCER CONTROL PLANNING EFFORTS WITH GLOBAL NONCOMMUNICABLE DISEASE (NCD) CONTROL TARGETS SO ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 [Vinson, Cynthia; Stevens, Lisa] NCI, Bethesda, MD 20892 USA. [Torode, Julie] UICC, Geneva, Switzerland. [Saraiya, Mona] Ctr Dis Control & Prevent, Atlanta, GA USA. [Sutcliffe, Simon] Int Canc Control Congress Assoc, Vancouver, BC, Canada. [Gospodacrowicz, Mary] Univ Toronto, Princess Margaret Hosp, Toronto, ON, Canada. [Anderson, Benjamin] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Adewole, Isaac] African Org Res & Training Canc, Ibadan, Nigeria. [Luciani, Silvana] Pan Amer Hlth Org, Washington, DC USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1743-7555 EI 1743-7563 J9 ASIA-PAC J CLIN ONCO JI Asia-Pac. J. Clin. Oncol. PD DEC PY 2014 VL 10 SU 9 SI SI MA 326 BP 8 EP 8 PG 1 WC Oncology SC Oncology GA AW5XG UT WOS:000346343700022 ER PT J AU Tangka, F Subramanian, S Cole-Beebe, M Gakunga, R Saraiya, M Korir, A Buziba, N Parkin, M AF Tangka, Florence Subramanian, Sujha Cole-Beebe, Maggie Gakunga, Robai Saraiya, Mona Korir, Ann Buziba, Nathan Parkin, Max TI RESOURCE REQUIREMENT FOR CANCER REGISTRATION IN LOW AND MIDDLE INCOME COUNTRIES: A CASE STUDY IN KENYA SO ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 [Tangka, Florence; Saraiya, Mona] CDC, Atlanta, GA 30333 USA. [Subramanian, Sujha; Cole-Beebe, Maggie] RTI Int, Chapel Hill, NC USA. [Korir, Ann] KEMRI, Nairobi, Kenya. [Buziba, Nathan] Eldoret Univ, Eldoret, England. [Parkin, Max] Univ Oxford, Oxford, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1743-7555 EI 1743-7563 J9 ASIA-PAC J CLIN ONCO JI Asia-Pac. J. Clin. Oncol. PD DEC PY 2014 VL 10 SU 9 SI SI MA 522 BP 51 EP 51 PG 1 WC Oncology SC Oncology GA AW5XG UT WOS:000346343700146 ER PT J AU Xia, Y Hsia, J AF Xia, Yang Hsia, Jason TI TOBACCO-SPECIFIC PULMONARY CARCINOGEN HIGHER IN OLDER SMOKERS IN THE UNITED STATES: NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY 2007-2012 SO ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 [Xia, Yang; Hsia, Jason] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1743-7555 EI 1743-7563 J9 ASIA-PAC J CLIN ONCO JI Asia-Pac. J. Clin. Oncol. PD DEC PY 2014 VL 10 SU 9 SI SI MA 532 BP 54 EP 54 PG 1 WC Oncology SC Oncology GA AW5XG UT WOS:000346343700156 ER PT J AU Sun, L Dickie, L Adamo, P Li, J Houston, K Su, J AF Sun, Leon Dickie, Lois Adamo, Peggy Li, Jun Houston, Keisha Su, Joseph TI EPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS OF PROSTATE CANCER MEN WITH MULTIPLE CANCERS SO ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 [Sun, Leon; Dickie, Lois; Adamo, Peggy] NCI, NIH, Rockville, MD USA. [Li, Jun] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1743-7555 EI 1743-7563 J9 ASIA-PAC J CLIN ONCO JI Asia-Pac. J. Clin. Oncol. PD DEC PY 2014 VL 10 SU 9 SI SI MA 539 BP 56 EP 57 PG 2 WC Oncology SC Oncology GA AW5XG UT WOS:000346343700163 ER PT J AU Tangka, F Subramanian, S Hoover, S Cole-Beebe, M DeGroff, A Joseph, K Royalty, J Saraiya, M AF Tangka, Florence Subramanian, Suhja Hoover, Sonja Cole-Beebe, Maggie DeGroff, Amy Joseph, Kristy Royalty, Janet Saraiya, Mona TI VARIATION IN THE COST OF PROMOTING CANCER SCREENING: REAL WORLD EXPERIENCE FROM CDC'S COLORECTAL CANCER CONTROL PROGRAM IN THE USA SO ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 [Tangka, Florence; DeGroff, Amy; Joseph, Kristy; Royalty, Janet; Saraiya, Mona] CDC, Atlanta, GA 30333 USA. [Subramanian, Suhja; Hoover, Sonja; Cole-Beebe, Maggie] RTI Int, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1743-7555 EI 1743-7563 J9 ASIA-PAC J CLIN ONCO JI Asia-Pac. J. Clin. Oncol. PD DEC PY 2014 VL 10 SU 9 SI SI MA 1173 BP 240 EP 241 PG 2 WC Oncology SC Oncology GA AW5XG UT WOS:000346343700731 ER PT J AU Zhao, GX Okoro, CA Li, J White, A Dhingra, S Li, CY AF Zhao, Guixiang Okoro, Catherine A. Li, Jun White, Arica Dhingra, Satvinder Li, Chaoyang TI Current depression among adult cancer survivors: Findings from the 2010 Behavioral Risk Factor Surveillance System SO CANCER EPIDEMIOLOGY LA English DT Article DE Cancer survivor; Current depression; Depressive symptoms; Patient Health Questionnaire-8 (PHQ-8); BRFSS ID QUALITY-OF-LIFE; HEALTH INTERVIEW SURVEY; LONG-TERM SURVIVORS; PSYCHOLOGICAL DISTRESS; BREAST-CANCER; UNITED-STATES; ANXIETY; POPULATION; PREVALENCE; DIAGNOSIS AB Background: A cancer diagnosis and subsequent treatments constitute a significantly increased psychological burden among cancer patients. This study examined the prevalence of current depression and the risk factors associated with a high burden of depression among cancer survivors in the US. Methods: We analyzed data from 3550 cancer survivors (aged >= 18 years) and 26,917 adults without cancer who participated in the 2010 Behavioral Risk Factor Surveillance System. Depressive symptoms were assessed by the Patient Health Questionnaire-8 diagnostic algorithm. Participants with a total depression severity score of >= 10 were defined as having current depression. Prevalence and prevalence ratios were estimated by conducting log-linear regression analysis while controlling for potential confounders. Results: Overall, 13.7% of cancer survivors (vs. 8.9% of adults without cancer, P < 0.001) reported having current depression; the prevalence varied significantly by cancer category. Among cancer survivors, after multivariate adjustment for covariates, cancer diagnosis within a year, being in 'other' racial/ethnic group, divorced, separated, widowed, or never married, current or former smoker, or having histories of diabetes, disability, or depression were associated with significantly higher prevalence ratios for current depression; whereas being at an advanced age (>= 60 years old), attaining educational levels of >high school graduate, or engaging in leisure-time physical activity were associated with significantly lower prevalence ratios for current depression. Conclusion: Our results indicate that cancer survivors are at increased risk of current depression. Targeting cancer survivors at high risk of depressive issues may be especially important for clinical support and interventions aimed at improving mental well-being. Published by Elsevier Ltd. C1 [Zhao, Guixiang; Okoro, Catherine A.; Li, Chaoyang] Ctr Dis Control & Prevent, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30345 USA. [Li, Jun; White, Arica] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30345 USA. [Dhingra, Satvinder] Northrop Grumman Corp, Atlanta, GA 30345 USA. [Li, Chaoyang] Ctr Dis Control & Prevent, Div Environm Hazards & Hlth Effects, Natl Ctr Environm Hlth, Atlanta, GA 30345 USA. RP Zhao, GX (reprint author), Ctr Dis Control & Prevent, 2500 Century Pkwy,Mailstop E-83, Atlanta, GA 30345 USA. EM GZhao@cdc.gov NR 45 TC 6 Z9 6 U1 5 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1877-7821 EI 1877-783X J9 CANCER EPIDEMIOL JI Cancer Epidemiol. PD DEC PY 2014 VL 38 IS 6 BP 757 EP 764 DI 10.1016/j.canep.2014.10.002 PG 8 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA AW8IC UT WOS:000346503900016 PM 25455653 ER PT J AU Haddad, LB Polis, CB Sheth, AN Brown, J Kourtis, AP King, C Chakraborty, R Ofotokun, I AF Haddad, Lisa B. Polis, Chelsea B. Sheth, Anandi N. Brown, Jennifer Kourtis, Athena P. King, Caroline Chakraborty, Rana Ofotokun, Igho TI Contraceptive Methods and Risk of HIV Acquisition or Female-to-Male Transmission SO CURRENT HIV/AIDS REPORTS LA English DT Article DE HIV; AIDS; Contraception; Hormonal contraception; Transmission ID DEPOT-MEDROXYPROGESTERONE ACETATE; SEXUALLY-TRANSMITTED INFECTIONS; ACTIVE ANTIRETROVIRAL THERAPY; HUMAN IMMUNODEFICIENCY VIRUS-1; LEUKOCYTE PROTEASE INHIBITOR; RANDOMIZED CONTROLLED-TRIAL; VAGINAL EPITHELIAL-CELLS; MESSENGER-RNA EXPRESSION; GENITAL-TRACT SECRETIONS; DUAL METHOD USE AB Effective family planning with modern contraception is an important intervention to prevent unintended pregnancies which also provides personal, familial, and societal benefits. Contraception is also the most cost-effective strategy to reduce the burden of mother-to-child HIV transmission for women living with HIV who wish to prevent pregnancy. There are concerns, however, that certain contraceptive methods, in particular the injectable contraceptive depot medroxyprogesterone acetate (DMPA), may increase a woman's risk of acquiring HIV or transmitting it to uninfected males. These concerns, if confirmed, could potentially have large public health implications. This paper briefly reviews the literature on use of contraception among women living with HIV or at high risk of HIV infection. The Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) recommendations place no restrictions on the use of hormonal contraceptive methods by women with or at high risk of HIV infection, although a clarification recommends that, given uncertainty in the current literature, women at high risk of HIV who choose progestogen-only injectable contraceptives should be informed that it may or may not increase their risk of HIV acquisition and should also be informed about and have access to HIV preventive measures, including male or female condoms. C1 [Haddad, Lisa B.] Emory Univ, Sch Med, Dept Gynecol & Obstet, Atlanta, GA 30303 USA. [Polis, Chelsea B.] USAID, Off Populat & Reprod Hlth, Washington, DC USA. [Sheth, Anandi N.; Ofotokun, Igho] Emory Univ, Sch Med, Dept Med, Div Infect Dis & Grady Healthcare Syst, Atlanta, GA 30303 USA. [Brown, Jennifer] Texas Tech Univ, Dept Psychol Sci, Lubbock, TX 79409 USA. [Kourtis, Athena P.; King, Caroline] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA. [Chakraborty, Rana] Emory Univ, Sch Med, Dept Pediat, Div Infect Dis, Atlanta, GA 30303 USA. RP Haddad, LB (reprint author), Emory Univ, Sch Med, Dept Gynecol & Obstet, 49 Jesse Hill Jr Dr, Atlanta, GA 30303 USA. EM lbhadda@emory.edu RI Ofotokun, Ighovwerha/L-6545-2015; OI Ofotokun, Ighovwerha/0000-0003-2735-1903; Polis, Chelsea/0000-0002-1031-7074 FU NIH; CDC; Gilead; Bristol-Myers Squibb FX Lisa B. Haddad, Chelsea B. Polis, Anandi N. Sheth, Athena P. Kourtis, and Caroline King declare that they have no conflict of interest.; Jennifer Brown has received a grant from the NIH.; Rana Chakraborty has received a grant from the CDC and Gilead.; Igho Ofotokun has received a grant from Bristol-Myers Squibb. NR 144 TC 5 Z9 5 U1 1 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1548-3568 EI 1548-3576 J9 CURR HIV-AIDS REP JI Curr. Hiv/Aids Rep. PD DEC PY 2014 VL 11 IS 4 BP 447 EP 458 DI 10.1007/s11904-014-0236-6 PG 12 WC Infectious Diseases SC Infectious Diseases GA AW4IY UT WOS:000346245800008 PM 25297973 ER PT J AU Kobau, R Cui, W Kadima, N Zack, MM Sajatovic, M Kaiboriboon, K Jobst, B AF Kobau, R. Cui, W. Kadima, N. Zack, M. M. Sajatovic, M. Kaiboriboon, K. Jobst, B. TI Tracking psychosocial health in adults with epilepsy-Estimates from the 2010 National Health Interview Survey SO EPILEPSY & BEHAVIOR LA English DT Article DE Epilepsy; Quality of life; Social participation; Cognition; Psychological distress; Limitations; Pain ID GENERAL-POPULATION; CHRONIC PAIN; PEOPLE; SURVEILLANCE; SATISFACTION; LAMOTRIGINE; COMORBIDITY; PREVALENCE; DEPRESSION; MANAGEMENT AB Objective: This study provides population-based estimates of psychosocial health among U.S. adults with epilepsy from the 2010 National Health Interview Survey. Methods: Multinomial logistic regression was used to estimate the prevalence of the following measures of psychosocial health among adults with epilepsy and those without epilepsy: 1) the Kessler-6 scale of serious psychological distress; 2) cognitive limitation, the extent of impairments associated with psychological problems, and work limitation; 3) social participation; and 4) the Patient-Reported Outcome Measurement Information System Global Health Scale. Results: Compared with adults without epilepsy, adults with epilepsy, especially those with active epilepsy, reported significantly worse psychological health, more cognitive impairment, difficulty in participating in some social activities, and reduced health-related quality of life ( HRQOL). Conclusions: These disparities in psychosocial health in U.S. adults with epilepsy serve as baseline national estimates of their HRQOL, consistent with Healthy People 2020 national objectives on HRQOL. Published by Elsevier Inc. C1 [Kobau, R.; Cui, W.; Zack, M. M.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Epilepsy Program, Atlanta, GA 30341 USA. [Kadima, N.] SciMetrika, Durham, NC 27713 USA. [Sajatovic, M.] Univ Hosp Case Med Ctr, Neurol Outcomes Ctr, Cleveland, OH 44106 USA. [Kaiboriboon, K.] San Francisco VA Med Ctr0, San Francisco, CA 94121 USA. [Jobst, B.] Dartmouth Hitchcock Epilepsy Ctr, Geisel Sch Med Dartmouth, Dept Neurol, Lebanon, NH 03756 USA. RP Kobau, R (reprint author), Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Populat Hlth, Epilepsy Program, 4770 Buford Highway NE,MS K-78, Atlanta, GA 30341 USA. EM rmk4@cdc.gov OI Kadima, Norbert/0000-0002-0746-2318 FU NIH; CDC; AES FX Barbara C. Jobst discloses the following: research support: NIH, CDC, and AES; commercial support: NeuroPace Inc., Lundbeck Inc., Upsher-Smith Inc., and Pfizer Inc.; medical writing: MedLink Inc.; and Scientific Advisory Board: NeuroPace Inc. NR 49 TC 11 Z9 11 U1 2 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1525-5050 EI 1525-5069 J9 EPILEPSY BEHAV JI Epilepsy Behav. PD DEC PY 2014 VL 41 BP 66 EP 73 DI 10.1016/j.yebeh.2014.08.002 PG 8 WC Behavioral Sciences; Clinical Neurology; Psychiatry SC Behavioral Sciences; Neurosciences & Neurology; Psychiatry GA AW3LH UT WOS:000346187700014 PM 25305435 ER PT J AU Yen, IH Flood, JF Thompson, H Anderson, LA Wong, G AF Yen, Irene H. Flood, Johnna Fandel Thompson, Hannah Anderson, Lynda A. Wong, Geoff TI How Design of Places Promotes or Inhibits Mobility of Older Adults: Realist Synthesis of 20 Years of Research SO JOURNAL OF AGING AND HEALTH LA English DT Article DE mobility; neighborhood; built environment; realist synthesis ID NEIGHBORHOOD WALKING ACTIVITY; PHYSICAL-ACTIVITY; BUILT ENVIRONMENT; SOCIOECONOMIC-STATUS; DEPRESSIVE SYMPTOMS; PUBLIC-HEALTH; UNITED-STATES; URBAN FORM; COMMUNITY; PEOPLE AB Objective: The objective of this study was to determine the environmental features that best support aging in place. Method: We conducted a realist synthesis, a theory-driven interpretive method of evidence synthesis, of 120+ articles (published 1991-2011) that attempts to explain how place may influence older adults' decisions about mobility (e.g., physical activity). We developed an initial program theory, reviewed the literature, identified outcomes, analyzed and synthesized patterns, and created a final program theory. Results: Safety was a central mechanism, serving as one of the bridges between environmental components (e.g., connectivity, aesthetics, retail and services) and decisions about mobility. Population density, sidewalk presence, and park proximity did not emerge as key factors. Discussion: Safety considerations are one of the most prominent influences of older adults' decisions about mobility. Street connectivity, pedestrian access and transit, and retail and services were also important. These factors are amenable to change and can help promote mobility for older adults. C1 [Yen, Irene H.; Thompson, Hannah] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Flood, Johnna Fandel] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Anderson, Lynda A.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Anderson, Lynda A.] Rollins Sch Publ Hlth, Atlanta, GA USA. [Wong, Geoff] Barts & London Queen Marys Sch Med & Dent, London, England. RP Yen, IH (reprint author), Univ Calif San Francisco, Dept Med, Div Gen Internal Med, 3333 Calif St,Suite 335, San Francisco, CA 94143 USA. EM irene.yen@ucsf.edu FU Intramural CDC HHS [CC999999] NR 72 TC 8 Z9 8 U1 2 U2 36 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0898-2643 EI 1552-6887 J9 J AGING HEALTH JI J. Aging Health PD DEC PY 2014 VL 26 IS 8 SI SI BP 1340 EP 1372 DI 10.1177/0898264314527610 PG 33 WC Gerontology; Health Policy & Services SC Geriatrics & Gerontology; Health Care Sciences & Services GA AW4PD UT WOS:000346262200006 PM 24788714 ER PT J AU Daep, CA Munoz-Jordan, JL Eugenin, EA AF Daep, Carlo Amorin Munoz-Jordan, Jorge L. Eugenin, Eliseo Alberto TI Flaviviruses, an expanding threat in public health: focus on dengue, West Nile, and Japanese encephalitis virus SO JOURNAL OF NEUROVIROLOGY LA English DT Review DE Vaccines; Mosquito; Fever; Bioterrorism; Brain ID BLOOD-BRAIN-BARRIER; HEPATITIS-C VIRUS; T-CELL RESPONSES; UNFOLDED PROTEIN RESPONSE; POLYMERASE CHAIN-REACTION; CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; YELLOW-FEVER VACCINE; TEXAS-MEXICO BORDER; NF-KAPPA-B AB The flaviviruses dengue, West Nile, and Japanese encephalitis represent three major mosquito-borne viruses worldwide. These pathogens impact the lives of millions of individuals and potentially could affect non-endemic areas already colonized by mosquito vectors. Unintentional transport of infected vectors (Aedes and Culex spp.), traveling within endemic areas, rapid adaptation of the insects into new geographic locations, climate change, and lack of medical surveillance have greatly contributed to the increase in flaviviral infections worldwide. The mechanisms by which flaviviruses alter the immune and the central nervous system have only recently been examined despite the alarming number of infections, related deaths, and increasing global distribution. In this review, we will discuss the expansion of the geographic areas affected by flaviviruses, the potential threats to previously unaffected countries, the mechanisms of pathogenesis, and the potential therapeutic interventions to limit the devastating consequences of these viruses. C1 [Daep, Carlo Amorin; Eugenin, Eliseo Alberto] PHRI, Newark, NJ USA. [Daep, Carlo Amorin; Eugenin, Eliseo Alberto] Rutgers State Univ, Rutgers New Jersey Med Sch, Dept Microbiol & Mol Genet, Newark, NJ 07102 USA. [Munoz-Jordan, Jorge L.] Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR 00971 USA. RP Eugenin, EA (reprint author), Rutgers State Univ, Rutgers New Jersey Med Sch, Dept Microbiol & Mol Genet, Newark, NJ 07102 USA. EM eliseo.eugenin@rutgers.edu FU Public Health Research Institute (PHRI); National Institutes of Mental Health [MH096625] FX This work was supported by funds from the Public Health Research Institute (PHRI) and National Institutes of Mental Health grant MH096625. We thank the PHRI shared facilities at Rutgers University, Newark, NJ, USA (http://phri.org/facilities/facil_imaging.asp). We also thank Jonathan Guito for critically reading and proof-reading this manuscript. NR 232 TC 23 Z9 24 U1 3 U2 36 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1355-0284 EI 1538-2443 J9 J NEUROVIROL JI J. Neurovirol. PD DEC PY 2014 VL 20 IS 6 BP 539 EP 560 DI 10.1007/s13365-014-0285-z PG 22 WC Neurosciences; Virology SC Neurosciences & Neurology; Virology GA AW4FX UT WOS:000346237700001 PM 25287260 ER PT J AU Miller, JW Baldwin, LM Matthews, B Trivers, KF Andrilla, CH Lishner, D Goff, BA AF Miller, Jacqueline W. Baldwin, Laura-Mae Matthews, Barbara Trivers, Katrina F. Andrilla, C. Holly Lishner, Denise Goff, Barbara A. TI Physicians' beliefs about effectiveness of cancer screening tests: A national survey of family physicians, general internists, and obstetrician-gynecologists SO PREVENTIVE MEDICINE LA English DT Article DE Cancer screening; Breast cancer; Cervical cancer; Colorectal cancer; Ovarian cancer; Physician beliefs ID PRIMARY-CARE-PHYSICIANS; EVIDENCE-BASED RECOMMENDATIONS; CLINICAL-PRACTICE GUIDELINES; SERVICES TASK-FORCE; FECAL OCCULT BLOOD; OVARIAN-CANCER; HUMAN-PAPILLOMAVIRUS; BREAST-CANCER; UNITED-STATES; US WOMEN AB Objective. To study physicians' beliefs about the effectiveness of different tests for cancer screening. Methods. Data were examined from the Women's Health Survey of 1574 Family Medicine, Internal Medicine, and Obstetrics-Gynecology physicians to questions about their level of agreement about the clinical effectiveness of different tests for breast, cervical, ovarian, and colorectal cancer screening among average risk women. Data were weighted to the U.S. physician population based on the American Medical Association Masterfile. Multivariable logistic regression identified physician and practice characteristics significantly associated with physicians' beliefs. Results. There were 1574 respondents, representing a 62% response rate. The majority of physicians agreed with the effectiveness of mammography for women aged 50-69 years, Pap tests for women aged 21-65 years, and colonoscopy for individuals aged >= 50 years. A substantial proportion of physicians believed that non-recommended tests were effective for screening (e.g., 34.4% for breast MRI and 69.1% for annual pelvic exam). Physicians typically listed their respective specialty organizations as a top influential organization for screening recommendations. Conclusions. There were several substantial inconsistencies between physician beliefs in the effectiveness of cancer screening tests and the actual evidence of these tests' effectiveness which can lead both to underuse and overuse of cancer screening tests. Published by Elsevier Inc. C1 [Miller, Jacqueline W.; Trivers, Katrina F.] Ctr Dis Control & Prevent, Div Canc Prevent & Control, Atlanta, GA 30341 USA. [Baldwin, Laura-Mae; Matthews, Barbara; Andrilla, C. Holly; Lishner, Denise] Univ Washington, Dept Family Med, Seattle, WA 98195 USA. [Goff, Barbara A.] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA. RP Miller, JW (reprint author), Ctr Dis Control & Prevent, Div Canc Prevent & Control, 4770 Buford Hwy NE,Mailstop K-76, Atlanta, GA 30341 USA. EM JMiller5@cdc.gov FU Centers for Disease Control and Prevention (CDC) through the University of Washington Health Promotion Research Centers [U48DP001911]; Centers for Disease Control and Prevention (CDC) through the Alliance for Reducing Cancer, Northwest (ARC NW); Centers for Disease Control and Prevention (CDC); National Cancer Institute (NCI) FX This project was funded by the Centers for Disease Control and Prevention (CDC) through the University of Washington Health Promotion Research Centers Cooperative Agreement U48DP001911, and through the Alliance for Reducing Cancer, Northwest (ARC NW), funded by both the Centers for Disease Control and Prevention (CDC) and the National Cancer Institute (NCI). NR 46 TC 3 Z9 3 U1 3 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 EI 1096-0260 J9 PREV MED JI Prev. Med. PD DEC PY 2014 VL 69 BP 37 EP 42 DI 10.1016/j.ypmed.2014.07.009 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AW3ZN UT WOS:000346221600008 PM 25038531 ER PT J AU Kempe, A Albright, K O'Leary, S Kolasa, M Barnard, J Kile, D Lockhart, S Dickinson, LM Shmueli, D Babbel, C Barrow, J AF Kempe, Allison Albright, Karen O'Leary, S. Kolasa, Maureen Barnard, Juliana Kile, Deidre Lockhart, Steven Dickinson, L. Miriam Shmueli, Doron Babbel, Christine Barrow, Jennifer TI Effectiveness of primary care-public health collaborations in the delivery of influenza vaccine: a cluster-randomized pragmatic trial SO PREVENTIVE MEDICINE LA English DT Article DE Influenza vaccine; Immunization delivery; Preventive health ID QUALITATIVE CONTENT-ANALYSIS; SEASONAL INFLUENZA; MONROE COUNTY; NEW-YORK; CHILDREN; COMMUNITY; IMMUNIZATION; RECOMMENDATIONS; SCHOOLCHILDREN; POPULATION AB Objective. To assess effectiveness and feasibility of public-private collaboration in delivering influenza immunization to children. Methods. Four pediatric and four family medicine (FM) practices in Colorado with a common public health department (PHD) were randomized at the beginning of baseline year (10/2009) to Intervention (joint community clinics and PHD nurses aiding in delivery at practices); or control involving usual care without PHD. Generalized estimating equations compared changes in rates over baseline between intervention and control practices at end of 2nd intervention year (Y2 = 5/2011). Barriers to collaboration were examined using qualitative methods. Results. Overall, rates increased from baseline to Y2 by 9.2% in intervention and 3.2% in control (p < .0001), with significant increases in both pediatric and FM practices. The largest increases were seen among school-aged and adolescent children (p < .0001 for both), with differences for 6-month-old to 5-year-old children and for children with high-risk conditions not reaching significance. Barriers to collaboration included uncertainty regarding the delivery of vaccine supplies, concerns about using up all purchased vaccine by practices, and concerns about documentation of vaccination if collaboration occurred. Conclusions. In spite of barriers, public-private collaboration resulted in significantly higher influenza immunization rates, particularly for older, healthy children who visit providers less frequently. (C) 2014 Elsevier Inc. All rights reserved C1 [Kempe, Allison; Albright, Karen; O'Leary, S.; Barnard, Juliana; Kile, Deidre; Lockhart, Steven; Dickinson, L. Miriam; Shmueli, Doron; Babbel, Christine; Barrow, Jennifer] Childrens Hosp, Childrens Outcomes Res Program, Aurora, CO USA. [Kempe, Allison; O'Leary, S.] Univ Colorado, Dept Pediat, Aurora, CO 80045 USA. [Kempe, Allison; Albright, Karen] Univ Colorado, Colorado Hlth Outcomes Program, Aurora, CO 80045 USA. [Albright, Karen] Univ Colorado, Colorado Sch Publ Hlth, Aurora, CO 80045 USA. [Kolasa, Maureen] CDC, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Dickinson, L. Miriam] Univ Colorado, Dept Family Med, Aurora, CO 80045 USA. RP Kempe, A (reprint author), Univ Colorado, Dept Pediat, Mail Stop F443,13199 E Montview Blvd,Suite 300, Aurora, CO 80045 USA. EM allison.kempe@childrenscolorado.org FU Centers for Disease Control and Prevention [U01 IP000320] FX This investigation was funded by a grant from the Centers for Disease Control and Prevention(#U01 IP000320). NR 39 TC 3 Z9 3 U1 0 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0091-7435 EI 1096-0260 J9 PREV MED JI Prev. Med. PD DEC PY 2014 VL 69 BP 110 EP 116 DI 10.1016/j.ypmed.2014.08.019 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA AW3ZN UT WOS:000346221600019 PM 25152506 ER PT J AU Thiese, MS Gerr, F Hegmann, KT Harris-Adamson, C Dale, AM Evanoff, B Eisen, EA Kapellusch, J Garg, A Burt, S Bao, S Silverstein, B Merino, L Rempel, D AF Thiese, Matthew S. Gerr, Fred Hegmann, Kurt T. Harris-Adamson, Carisa Dale, Ann Marie Evanoff, Bradley Eisen, Ellen A. Kapellusch, Jay Garg, Arun Burt, Susan Bao, Stephen Silverstein, Barbara Merino, Linda Rempel, David TI Effects of Varying Case Definition on Carpal Tunnel Syndrome Prevalence Estimates in a Pooled Cohort SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Carpal tunnel syndrome; Diagnostic techniques and procedures; Electrodiagnosis; Prevalence; Rehabilitation; Standards ID ULNAR NERVE-CONDUCTION; NC-STAT; MEDIAN NERVE; RING FINGER; CRITERION VALIDITY; GENERAL-POPULATION; INDUSTRIAL-WORKERS; SENSORY LATENCIES; SCREENING TOOL; NORMAL VALUES AB Objective: To analyze differences in carpal tunnel syndrome (CTS) prevalence using a combination of electrodiagnostic studies (EDSs) and symptoms using EDS criteria varied across a range of cutpoints and compared with symptoms in both >= 1 and >= 2 median nerve-served digits. Design: Pooled data from 5 prospective cohorts. Setting: Hand-intensive industrial settings, including manufacturing, assembly, production, service, construction, and health care. Participants: Employed, working-age participants who are able to provide consent and undergo EDS testing (N=3130). Interventions: None. Main Outcome Measures: CTS prevalence was estimated while varying the thresholds for median sensory latency, median motor latency, and transcarpal delta latency difference. EDS criteria examined included the following: median sensory latency of 3.3 to 4.1 milliseconds, median motor latency of 4.1 to 4.9 milliseconds, and median-ulnar sensory difference of 0.4 to 1.2 milliseconds. EDS criteria were combined with symptoms in >= 1 or >= 2 median nerve served digits. EDS criteria from other published studies were applied to allow for comparison. Results: CTS prevalence ranged from 6.3% to 11.7%. CTS prevalence estimates changed most per millisecond of sensory latency compared with motor latency or transcarpal delta. CTS prevalence decreased by 0.9% to 2.0% if the criteria required symptoms in 2 digits instead of 1. Conclusions: There are meaningful differences in CTS prevalence when different EDS criteria are applied. The digital sensory latency criteria result in the largest variance in prevalence. (C) 2014 by the American Congress of Rehabilitation Medicine C1 [Thiese, Matthew S.; Hegmann, Kurt T.] Univ Utah, Rocky Mt Ctr Occupat & Environm Hlth, Salt Lake City, UT 84108 USA. [Gerr, Fred; Merino, Linda] Univ Iowa, Coll Publ Hlth, Dept Environm & Occupat Hlth, Iowa City, IA USA. [Harris-Adamson, Carisa] Samuel Merritt Univ, Dept Phys Therapy, Oakland, CA USA. [Dale, Ann Marie; Evanoff, Bradley] Washington Univ, Sch Med, Div Gen Med Sci, St Louis, MO USA. [Eisen, Ellen A.] Univ Calif Berkeley, Dept Environm Hlth Sci, Berkeley, CA 94720 USA. [Kapellusch, Jay; Garg, Arun] Univ Wisconsin, Ctr Ergon, Milwaukee, WI 53201 USA. [Burt, Susan] NIOSH, Cincinnati, OH 45226 USA. [Bao, Stephen; Silverstein, Barbara] Washington State Dept Labor & Ind, Safety & Hlth Assessment & Res Prevent Program, Olympia, WA 98504 USA. [Rempel, David] Univ Calif San Francisco, Div Occupat & Environm Med, San Francisco, CA 94143 USA. RP Thiese, MS (reprint author), Univ Utah, Rocky Mt Ctr Occupat & Environm Hlth, 391 Chipeta Way,Ste C, Salt Lake City, UT 84108 USA. EM matt.thiese@hsc.utah.edu RI Dale, Ann Marie/P-1382-2014; OI Dale, Ann Marie/0000-0002-5624-8967; Evanoff, Bradley A./0000-0003-0085-333X; Thiese, Matthew/0000-0003-4505-2907 FU National Institute for Occupational Safety and Health [R01-OH009712]; National Institute for Occupational Safety and Health Education and Research Center [T42/CCT810426-10]; National Center for Research Resources, a component of the National Institutes of Health; National Institutes of Health Roadmap for Medical Research [UL1 RR024992] FX Supported by the National Institute for Occupational Safety and Health (grant no. R01-OH009712); National Institute for Occupational Safety and Health Education and Research Center (training grant no. T42/CCT810426-10); National Center for Research Resources, a component of the National Institutes of Health; and National Institutes of Health Roadmap for Medical Research (grant no. UL1 RR024992). NR 59 TC 8 Z9 8 U1 1 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 EI 1532-821X J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD DEC PY 2014 VL 95 IS 12 BP 2320 EP 2326 DI 10.1016/j.apmr.2014.08.004 PG 7 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA AW0AY UT WOS:000345954000012 PM 25175160 ER PT J AU Nguyen, DT Bryant, JE Davis, CT Nguyen, LV Pham, LT Loth, L Inui, K Nguyen, T Jang, Y To, TL Nguyen, TD Hoang, DT Do, HT Nguyen, TT Newman, S Siembieda, J Pham, DV AF Nguyen, Diep T. Bryant, Juliet E. Davis, C. Todd Nguyen, Long V. Pham, Long T. Loth, Leo Inui, Ken Tung Nguyen Jang, Yunho To, Thanh L. Nguyen, Tho D. Hoang, Diep T. Do, Hoa T. Nguyen, Trang T. Newman, Scott Siembieda, Jennifer Pham, Dong V. TI Prevalence and Distribution of Avian Influenza A(H5N1) Virus Clade Variants in Live Bird Markets of Vietnam, 2011-2013 SO AVIAN DISEASES LA English DT Article DE Vietnam; influenza; H5N1; surveillance; live bird markets; poultry ID H5N1 VIRUS; POULTRY; EMERGENCE; EVOLUTION; ENTRY; PORTS AB Active surveillance for avian influenza (AI) viruses in poultry sold at live bird markets (LBMs) was conducted in 44 of 63 provinces throughout Vietnam over two periods from September 2011 to February 2012 and October 2012 to June 2013. The study objectives were to assess the prevalence of avian influenza type A, H5, and H5N1 subtype viruses and characterize the geographical and temporal distribution of H5N1 virus genetic variants across the country. Monthly sampling was conducted in 394 LBMs located in 372 communes. A total of 9790 oropharyngeal swabs from poultry were screened for influenza A virus by real-time reverse-transcriptase PCR. Virus isolation was attempted on all positive samples in embryonated chicken eggs, and the HA1 region of each H5 virus isolate was sequenced. Market prevalence of H5 subtype virus was 32.2% (127/394) over the cumulative 15 mo of surveillance. Phylogenetic analyses indicated that clade 1.1 viruses persisted in the south, whereas three genetically distinct subgroups of clade 2.3.2.1 were found simultaneously in northern, central, and southern Vietnam. Clade 2.3.2.1c viruses first appeared in July 2012 and spread rapidly to the center and south of Vietnam in late 2012, where they were predominant among clade 2.3.2.1 viruses and were detected in both active LBM surveillance and poultry outbreaks. Given the overlapping geographic distribution of clade variants and the antigenic divergence previously described for these clades, current AI poultry vaccines used in Vietnam may require bivalent formulations containing representatives of both clade 1.1 and clade 2.3.2.1 viruses. C1 [Nguyen, Diep T.; Tung Nguyen; To, Thanh L.; Nguyen, Tho D.; Hoang, Diep T.; Do, Hoa T.; Nguyen, Trang T.] Natl Ctr Vet Diagnost, Dept Anim Hlth, Hanoi, Vietnam. [Nguyen, Diep T.; Bryant, Juliet E.] Univ Oxford, Clin Res Unit, Hanoi, Vietnam. [Nguyen, Diep T.; Bryant, Juliet E.] Wellcome Trust Major Overseas Programme, Hanoi, Vietnam. [Nguyen, Diep T.; Bryant, Juliet E.] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England. [Davis, C. Todd; Jang, Yunho] Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA. [Nguyen, Long V.; Pham, Long T.; Tung Nguyen; Pham, Dong V.] Minist Agr & Rural Dev Vietnam, Dept Anim Hlth, Hanoi, Vietnam. [Loth, Leo; Inui, Ken; Newman, Scott; Siembieda, Jennifer] UN, FAO, Hanoi, Vietnam. RP Nguyen, DT (reprint author), Natl Ctr Vet Diagnost, Dept Anim Hlth, Hanoi, Vietnam. EM ntdiep@dah.gov.vn; jbryant@oucru.org FU USAID; FAO FX We are grateful to the DAH and the FAO of the United Nations for providing data. The surveillance program was conducted with the financial support from the USAID, with technical guidance and support from FAO. We thank staff of DAH, NCVD, RAHOs, SDAHs of Vietnam and field veterinary staff for their support in collecting and testing samples. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the U.S. Centers for Disease Control and Prevention or the Agency for Toxic Substances and Disease Registry. We thank Rogier van Doorn for critical review of early drafts of the manuscript. NR 24 TC 8 Z9 8 U1 1 U2 12 PU AMER ASSOC AVIAN PATHOLOGISTS PI ATHENS PA 953 COLLEGE STATION RD, ATHENS, GA 30602-4875 USA SN 0005-2086 EI 1938-4351 J9 AVIAN DIS JI Avian Dis. PD DEC PY 2014 VL 58 IS 4 BP 599 EP 608 PG 10 WC Veterinary Sciences SC Veterinary Sciences GA AW2AF UT WOS:000346089800012 PM 25619005 ER PT J AU Altekruse, SF Rosenfeld, GE Carrick, DM Pressman, EJ Schully, SD Mechanic, LE Cronin, KA Hernandez, BY Lynch, CF Cozen, W Khoury, MJ Penberthy, LT AF Altekruse, Sean F. Rosenfeld, Gabriel E. Carrick, Danielle M. Pressman, Emilee J. Schully, Sheri D. Mechanic, Leah E. Cronin, Kathleen A. Hernandez, Brenda Y. Lynch, Charles F. Cozen, Wendy Khoury, Muin J. Penberthy, Lynne T. TI SEER Cancer Registry Biospecimen Research: Yesterday and Tomorrow SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID PARAFFIN-EMBEDDED TISSUES; EPITHELIAL HISTOPATHOLOGIC MARKERS; HUMAN-PAPILLOMAVIRUS TYPES; PRE-RITUXIMAB ERA; B-CELL LYMPHOMA; UNITED-STATES; PROTEIN EXPRESSION; COLORECTAL-CANCER; VACCINE INTRODUCTION; DNA METHYLATION AB The National Cancer Institute's (NCI) Surveillance, Epidemiology, and End Results (SEER) registries have been a source of biospecimens for cancer research for decades. Recently, registry-based biospecimen studies have become more practical, with the expansion of electronic networks for pathology and medical record reporting. Formalin-fixed paraffin-embedded specimens are now used for next-generation sequencing and other molecular techniques. These developments create new opportunities for SEER biospecimen research. We evaluated 31 research articles published during 2005 to 2013 based on authors' confirmation that these studies involved linkage of SEER data to biospecimens. Rather than providing an exhaustive review of all possible articles, our intent was to indicate the breadth of research made possible by such a resource. We also summarize responses to a 2012 questionnaire that was broadly distributed to the NCI intra- and extramural biospecimen research community. This included responses from 30 investigators who had used SEER biospecimens in their research. The survey was not intended to be a systematic sample, but instead to provide anecdotal insight on strengths, limitations, and the future of SEER biospecimen research. Identified strengths of this research resource include biospecimen availability, cost, and annotation of data, including demographic information, stage, and survival. Shortcomings include limited annotation of clinical attributes such as detailed chemotherapy history and recurrence, and timeliness of turnaround following biospecimen requests. A review of selected SEER biospecimen articles, investigator feedback, and technological advances reinforced our view that SEER biospecimen resources should be developed. This would advance cancer biology, etiology, and personalized therapy research. (C) 2014 AACR. C1 [Altekruse, Sean F.; Rosenfeld, Gabriel E.; Carrick, Danielle M.; Pressman, Emilee J.; Schully, Sheri D.; Mechanic, Leah E.; Cronin, Kathleen A.; Khoury, Muin J.; Penberthy, Lynne T.] NCI, Div Canc Control & Populat Sci, NIH, Rockville, MD 20850 USA. [Hernandez, Brenda Y.] Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA. [Lynch, Charles F.] Univ Iowa, Dept Epidemiol, Coll Publ Hlth, Iowa City, IA USA. [Cozen, Wendy] Univ So Calif, Dept Prevent Med, Keck Sch Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA. [Cozen, Wendy] Univ So Calif, Dept Pathol, Keck Sch Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA. [Khoury, Muin J.] Ctr Dis Control & Prevent, Off Publ Hlth Gen, Atlanta, GA USA. RP Altekruse, SF (reprint author), NCI, Div Canc Control & Populat Sci, 9609 Med Ctr Dr,Room 4E536, Rockville, MD 20850 USA. EM altekrusesf@mail.nih.gov FU Intramural NIH HHS [Z99 CA999999] NR 46 TC 3 Z9 3 U1 1 U2 4 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 EI 1538-7755 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD DEC PY 2014 VL 23 IS 12 BP 2681 EP 2687 DI 10.1158/1055-9965.EPI-14-0490 PG 7 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA AW0FU UT WOS:000345967300009 PM 25472677 ER PT J AU Simon, AE Schoendorf, KC AF Simon, Alan E. Schoendorf, Kenneth C. TI Emergency Department Visits for Mental Health Conditions Among US Children, 2001-2011 SO CLINICAL PEDIATRICS LA English DT Article DE emergency department; mental health; children; trends ID CARE; TRENDS AB We examined mental health-related visits to emergency departments (EDs) among children from 2001 to 2011. We used the National Hospital Ambulatory Medical Care Survey-Emergency Department, 2001-2011 to identify visits of children 6 to 20 years old with a reason-for-visit code or ICD-9-CM diagnosis code reflecting mental health issues. National percentages of total visits, visit counts, and population rates were calculated, overall and by race, age, and sex. Emergency department visits for mental health issues increased from 4.4% of all visits in 2001 to 7.2% in 2011. Counts increased 55 000 visits per year and rates increased from 13.6 visits/1000 population in 2001 to 25.3 visits/1000 in 2011 (P < .01 for all trends). Black children (all ages) had higher visit rates than white children and 13- to 20-year-olds had higher visit rates than children 6 to 12 years old (P < .01 for all comparisons). Differences between groups did not decline over time. C1 [Simon, Alan E.; Schoendorf, Kenneth C.] Ctr Dis Control & Prevent, Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA. [Schoendorf, Kenneth C.] US PHS, Rockville, MD USA. RP Simon, AE (reprint author), Natl Ctr Hlth Stat, 3311 Toledo Rd,Room 6122, Hyattsville, MD 20782 USA. EM fpa8@cdc.gov FU Intramural CDC HHS [CC999999] NR 23 TC 5 Z9 5 U1 1 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 EI 1938-2707 J9 CLIN PEDIATR JI Clin. Pediatr. PD DEC PY 2014 VL 53 IS 14 BP 1359 EP 1366 DI 10.1177/0009922814541806 PG 8 WC Pediatrics SC Pediatrics GA AW1YN UT WOS:000346084900007 PM 25006117 ER PT J AU Walsh, KA Bennett, SD Mahovic, M Gould, LH AF Walsh, Kelly A. Bennett, Sarah D. Mahovic, Michael Gould, L. Hannah TI Outbreaks Associated with Cantaloupe, Watermelon, and Honeydew in the United States, 1973-2011 SO FOODBORNE PATHOGENS AND DISEASE LA English DT Article ID LISTERIA-MONOCYTOGENES; MULTISTATE OUTBREAK; FRESH PRODUCE; SALMONELLA; MELONS; ILLNESS; GROWTH AB Fresh fruits and vegetables are an important part of a healthy diet. Melons have been associated with enteric infections. We reviewed outbreaks reported to the Centers for Disease Control and Prevention's Foodborne Disease Outbreak Surveillance System during 1973-2011 in which the implicated food was a single melon type. We also reviewed published literature and records obtained from investigating agencies. During 1973-2011, 34 outbreaks caused by a single melon type were reported, resulting in 3602 illnesses, 322 hospitalizations, 46 deaths, and 3 fetal losses. Cantaloupes accounted for 19 outbreaks (56%), followed by watermelons (13, 38%) and honeydew (2, 6%). Melon-associated outbreaks increased from 0.5 outbreaks per year during 1973-1991 to 1.3 during 1992-2011. Salmonella was the most common etiology reported (19, 56%), followed by norovirus (5, 15%). Among 13 outbreaks with information available, melons imported from Mexico and Central America were implicated in 9 outbreaks (69%) and domestically grown melons were implicated in 4 outbreaks (31%). The point of contamination was known for 20 outbreaks; contamination occurred most commonly during growth, harvesting, processing, or packaging (13, 65%). Preventive measures focused on reducing bacterial contamination of melons both domestically and internationally could decrease the number and severity of melon-associated outbreaks. C1 [Walsh, Kelly A.; Bennett, Sarah D.; Gould, L. Hannah] Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, Atlanta, GA 30333 USA. [Mahovic, Michael] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD USA. RP Walsh, KA (reprint author), Ctr Dis Control & Prevent, Div Foodborne Waterborne & Environm Dis, 1600 Clifton Rd NE,Mailstop C-09, Atlanta, GA 30333 USA. EM kwalsh@cdc.gov FU Intramural CDC HHS [CC999999] NR 35 TC 12 Z9 12 U1 3 U2 30 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1535-3141 EI 1556-7125 J9 FOODBORNE PATHOG DIS JI Foodborne Pathog. Dis. PD DEC 1 PY 2014 VL 11 IS 12 BP 945 EP 952 DI 10.1089/fpd.2014.1812 PG 8 WC Food Science & Technology SC Food Science & Technology GA AW4LZ UT WOS:000346253800005 PM 25407556 ER EF