FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Burgess, RM
Terletskaya, AV
Milyukin, MV
Povolotskii, M
Demchenko, VY
Bogoslavskaya, TA
Topkin, YV
Vorobyova, TV
Petrov, AN
Lyashenko, A
Ho, KT
AF Burgess, Robert M.
Terletskaya, Anna V.
Milyukin, Mykhailo V.
Povolotskii, Mark
Demchenko, Victor Y.
Bogoslavskaya, Tatiyana A.
Topkin, Yuri V.
Vorobyova, Tatiyana V.
Petrov, Alexei N.
Lyashenko, Artem
Ho, Kay T.
TI Concentration and distribution of hydrophobic organic contaminants and
metals in the estuaries of Ukraine
SO MARINE POLLUTION BULLETIN
LA English
DT Article
DE Estuaries; Sediments; Baseline hydrophobic organic contaminants;
Baseline metals; Ukraine; Black Sea
ID POLYCYCLIC AROMATIC-HYDROCARBONS; FORMER SOVIET-UNION; BLACK-SEA;
CHEMICAL CONCENTRATIONS; TRACE-METAL; POLYCHLORINATED-BIPHENYLS;
PARTICULATE MATTER; MARINE-SEDIMENTS; DNIEPER RIVER; ADRIATIC SEA
AB In this study of Ukrainian estuaries, sediments and tissues from the Dnieper and Boh estuaries and Danube Delta on the mainland, Sevastopol and Balaklava Bays on the Crimean Peninsula, and coastal Black Sea along the Crimean Peninsula were collected in 2006. Contaminant analyses included several metals. the hydrophobic organic chemicals (HOCs) polychlorinated biphenyls, several chlorinated pesticides, and polycyclic aromatic hydrocarbons. When compared to estuarine sediments globally, the Ukrainian sediments were found to be moderately contaminated. However, several metals, especially mercury, were often shown to be elevated in the tissues of the Ukrainian organisms in comparison to organisms from other estuarine locations. Sediment quality guidelines indicate some of the estuarine sediments could be sufficiently contaminated to cause adverse toxicological effects. This investigation represents the first extensive study of HOC and metal baseline concentrations and distributions in Ukrainian estuaries and seeks to characterize exposures to aquatic organisms living in these systems. Published by Elsevier Ltd.
C1 [Burgess, Robert M.; Ho, Kay T.] US EPA, ORD NHEERL Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Terletskaya, Anna V.; Milyukin, Mykhailo V.; Demchenko, Victor Y.; Bogoslavskaya, Tatiyana A.; Topkin, Yuri V.; Vorobyova, Tatiyana V.] Natl Acad Sci, Inst Colloidal Chem & Chem Water, Kiev, Ukraine.
[Povolotskii, Mark] Natl Acad Sci, Inst Organ Chem, Kiev, Ukraine.
[Petrov, Alexei N.] Natl Acad Sci, Inst Biol So Seas, Sevastopol, Ukraine.
[Lyashenko, Artem] Natl Acad Sci, Inst Hydrobiol, Kiev, Ukraine.
RP Burgess, RM (reprint author), US EPA, ORD NHEERL Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM burgess.robert@epa.gov
RI Petrov, Alexei/F-7084-2016
OI Petrov, Alexei/0000-0002-0137-486X
FU Science and Technology Center of Ukraine (STCU); NHEERL-AED,
Narragansett [AED-06-019]
FX The following internal reviewers are thanked for their insightful
comments: Joseph LiVolsi, Richard McKinney, Wayne Munns, Monique Perron
andjonathan Serbst. Also, our colleagues at the Institute of
Hydrobiology (Kyiv, Ukraine) and the Institute of Biology of the
Southern Seas (Sevastopol, Ukraine) are thanked for collecting the
sediment and tissue samples. This research was funded by the United
States Department of State and Environmental Protection Agency Former
Bio-Chem Weapons Scientists Re-direct Program administered by the
Science and Technology Center of Ukraine (STCU). The authors wish to
thank Iryna Tomashevska (STCU) and Doug Steele (US EPA) for their
administrative support of this research. This paper is dedicated to the
late Bill Freeman (US EPA) for his tireless support of this research and
the Re-Direct program; This is NHEERL-AED, Narragansett Contribution
AED-06-019.
NR 63
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U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0025-326X
EI 1879-3363
J9 MAR POLLUT BULL
JI Mar. Pollut. Bull.
PD AUG
PY 2009
VL 58
IS 8
BP 1103
EP 1115
DI 10.1016/j.marpolbul.2009.04.013
PG 13
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 485RS
UT WOS:000269142000012
PM 19446854
ER
PT J
AU Shears, SB
AF Shears, Stephen B.
TI Diphosphoinositol Polyphosphates: Metabolic Messengers?
SO MOLECULAR PHARMACOLOGY
LA English
DT Review
ID ACTIVATED PROTEIN-KINASE; INOSITOL HEXAKISPHOSPHATE KINASE-2; CYCLIC
ADENINE RIBONUCLEOTIDE; OVARIAN-CARCINOMA CELLS;
SACCHAROMYCES-CEREVISIAE; CELLULAR SENESCENCE; TELOMERE LENGTH; IN-VIVO;
MYOINOSITOL HEXAKISPHOSPHATE; RAT-LIVER
AB The diphosphoinositol polyphosphates ("inositol pyrophosphates") are a specialized subgroup of the inositol phosphate signaling family. This review proposes that many of the current data concerning the metabolic turnover and biological effects of the diphosphoinositol polyphosphates are linked by a common theme: these polyphosphates act as metabolic messengers. This review will also discuss the latest proposals concerning possible molecular mechanisms of action of this intriguing class of molecules.
C1 Natl Inst Environm Hlth Sci, Inositide Signaling Grp, NIH, DHHS, Res Triangle Pk, NC 27709 USA.
RP Shears, SB (reprint author), Natl Inst Environm Hlth Sci, Inositide Signaling Grp, NIH, DHHS, POB 12233, Res Triangle Pk, NC 27709 USA.
EM shears@niehs.nih.gov
FU Intramural Research Program of the National Institutes of Health
National Institute of Environmental Health Sciences
FX This work was supported by the Intramural Research Program of the
National Institutes of Health National Institute of Environmental Health
Sciences.
NR 172
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U1 0
U2 9
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0026-895X
J9 MOL PHARMACOL
JI Mol. Pharmacol.
PD AUG
PY 2009
VL 76
IS 2
BP 236
EP 252
DI 10.1124/mol.109.055897
PG 17
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 472SV
UT WOS:000268153400003
PM 19439500
ER
PT J
AU Dambacher, JM
Jones, KK
Larsen, DP
AF Dambacher, Jeffrey M.
Jones, Kim K.
Larsen, David P.
TI Landscape-Level Sampling for Status Review of Great Basin Redband Trout
SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT
LA English
DT Article
ID SMALL STREAMS; ABUNDANCE; HABITAT; RESOURCES
AB In response to a petition to list Great Basin redband trout (subspecies of rainbow trout Oncorhynchus mykiss) as threatened or endangered, the U.S. Fish and Wildlife Service conducted a status review in 1999. To Support that review, we conducted a survey of the abundances of redband trout in each of six subbasins of the Great Basin that included the states of Oregon, California, and Nevada. We used a generalized random-tessellation stratified algorithm to select a target sample size of 35 sites/subbasin. Out of a target number of 210 sites, 185 were visited by three-person crews that Surveyed stream habitat and estimated the abundance of fish populations in sample reaches with lengths that were nearly 20 times the respective channel widths. A minimal sampling intensity was based oil previously encountered levels of between-site variance in estimates of redband trout abundance. The total population estimate of age-1 and older (age-1+) redband trout in the Great Basin was 971,313 fish, with a 95% confidence interval equaling +/-15% of the mean estimate; 95% confidence limits ranged from 15% to 31% for population estimates in individual subbasins. Age-1+ fish abundance in terms of numerical density showed no significant differences between any subbasins. However, there were significant differences in terms of biomass: Catlow Valley subbasin biomass was significantly higher than the Great Basin mean, whereas Goose Lake subbasin biomass was significantly lower than the basinwide mean. These comparisons were supported by like differences in average weight. Analysis of stream habitat characteristics and fish abundance revealed no relationships that were generally consistent throughout the Great Basin, although spatial patterns were evident within some stream systems where sampling intensity was sufficiently high.
C1 [Dambacher, Jeffrey M.; Jones, Kim K.] Oregon Dept Fish & Wildlife, Corvallis, OR 97333 USA.
[Larsen, David P.] US EPA, Pacific States Marine Fisheries Commiss, Western Ecol Div, Corvallis, OR 97333 USA.
RP Dambacher, JM (reprint author), CSIRO Math & Informat Sci, Gen POB 1538, Hobart, Tas 7001, Australia.
EM jeffrey.dambacher@csiro.au
RI Dambacher, Jeffrey/A-2200-2008
FU USGS Species at Risk Program; Oregon Department of Environmental
Quality; U.S. Bureau of Land Management Lakeview District; USFWS Oregon
State Office
FX We thank field crews from ODFW and the U.S. Forest Service for survey
and sampling efforts, and we are grateful to Tony Olsen for guidance in
the use of GRTS protocol and for selecting locations of sample sites.
This study was made possible by funding from the USGS Species at Risk
Program, Oregon Department of Environmental Quality, U.S. Bureau of Land
Management Lakeview District, and USFWS Oregon State Office. We thank
the Harney County Court and the Lake County Board of Commissioners for
support in gaining access to private lands for field sampling. We thank
three anonymous reviewers and Jason Dunham for comments that improved
the clarity of this work.
NR 26
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U1 0
U2 3
PU AMER FISHERIES SOC
PI BETHESDA
PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA
SN 0275-5947
J9 N AM J FISH MANAGE
JI North Am. J. Fish Manage.
PD AUG
PY 2009
VL 29
IS 4
BP 1091
EP 1105
DI 10.1577/M08-077.1
PG 15
WC Fisheries
SC Fisheries
GA 522UR
UT WOS:000272025000024
ER
PT J
AU Elam, MB
Cowan, GS
Rooney, RJ
Hiler, ML
Yellaturu, CR
Deng, X
Howell, GE
Park, EA
Gerling, IC
Patel, D
Corton, JC
Cagen, LM
Wilcox, HG
Gandhi, M
Bahr, MH
Allan, MC
Wodi, LA
Cook, GA
Hughes, TA
Raghow, R
AF Elam, Marshall B.
Cowan, George S., Jr.
Rooney, Robert J.
Hiler, M. Lloyd
Yellaturu, Chandrahasa R.
Deng, Xiong
Howell, George E.
Park, Edwards A.
Gerling, Ivan C.
Patel, Divyan
Corton, J. Christopher
Cagen, Lauren M.
Wilcox, Henry G.
Gandhi, Malay
Bahr, Micheal H.
Allan, Micheal C.
Wodi, Linus A.
Cook, George A.
Hughes, Thomas A.
Raghow, Rajendra
TI Hepatic Gene Expression in Morbidly Obese Women: Implications for
Disease Susceptibility
SO OBESITY
LA English
DT Article
ID INSULIN-RESISTANCE; WEIGHT-LOSS; NONALCOHOLIC STEATOHEPATITIS;
COLORECTAL-CANCER; GASTRIC BYPASS; ADIPOSE-TISSUE; UNITED-STATES;
LIVER-DISEASE; UP-REGULATION; RISK
AB The objective of this study was to determine the molecular bases of disordered hepatic function and disease susceptibility in obesity. We compared global gene expression in liver biopsies from morbidly obese (MO) women undergoing gastric bypass (GBP) surgery with that of women undergoing ventral hernia repair who had experienced massive weight loss (MWL) following prior GBP. Metabolic and hormonal profiles were examined in MO vs. MWL groups. Additionally, we analyzed individual profiles of hepatic gene expression in liver biopsy specimens obtained from MO and MWL subjects. All patients underwent preoperative metabolic profiling. RNAs were extracted from wedge biopsies of livers from MO and MWL subjects, and analysis of mRNA expression was carried out using Affymetrix HG-U133A microarray gene chips. Genes exhibiting greater than twofold differential expression between MO and MWL subjects were organized according to gene ontology and hierarchical clustering, and expression of key genes exhibiting differential regulation was quantified by real-time-polymerase chain reaction (RT-PCR). We discovered 154 genes to be differentially expressed in livers of MWL and MO subjects. A total of 28 candidate disease susceptibility genes were identified that encoded proteins regulating lipid and energy homeostasis (PLIN, ENO3, ELOVL2, APOF, LEPR, IGFBP1, DDIT4), signal transduction (MAP2K6, SOCS-2), postinflammatory tissue repair (HLA-DQB1, SPP1, P4HA1, LUM), bile acid transport (SULT2A, ABCB11), and metabolism of xenobiotics (GSTT2, CYP1A1). Using gene expression profiling, we have identified novel candidate disease susceptibility genes whose expression is altered in livers of MO subjects. The significance of altered expression of these genes to obesity-related disease is discussed.
C1 [Elam, Marshall B.; Gerling, Ivan C.; Raghow, Rajendra] Vet Affairs Med Ctr, Dept Med, Memphis, TN USA.
[Elam, Marshall B.; Gerling, Ivan C.; Raghow, Rajendra] Vet Affairs Med Ctr, Res Serv, Memphis, TN USA.
[Elam, Marshall B.; Yellaturu, Chandrahasa R.; Deng, Xiong; Howell, George E.; Park, Edwards A.; Cagen, Lauren M.; Wilcox, Henry G.; Cook, George A.; Raghow, Rajendra] Univ Tennessee, Ctr Hlth Sci, Dept Pharmacol, Memphis, TN 38163 USA.
[Cowan, George S., Jr.; Hiler, M. Lloyd; Bahr, Micheal H.] Univ Tennessee, Ctr Hlth Sci, Dept Surg, Memphis, TN 38163 USA.
[Rooney, Robert J.; Patel, Divyan] Genome Explorat Inc, Memphis, TN USA.
[Corton, J. Christopher] US EPA, Durham, NC USA.
[Gandhi, Malay; Allan, Micheal C.; Wodi, Linus A.; Hughes, Thomas A.] Univ Tennessee, Ctr Hlth Sci, Dept Med, Memphis, TN 38163 USA.
RP Elam, MB (reprint author), Vet Affairs Med Ctr, Dept Med, Memphis, TN USA.
EM melam@utmem.edu
FU NCRR NIH HHS [M01-RR0021]; NIDDK NIH HHS [R01-DK75504-01, R01 DK075504]
NR 61
TC 17
Z9 17
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD AUG
PY 2009
VL 17
IS 8
BP 1563
EP 1573
DI 10.1038/oby.2009.49
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 475QD
UT WOS:000268374200015
PM 19265796
ER
PT J
AU Hancock, DB
Romieu, I
Shi, M
Sienra-Monge, JJ
Wu, H
Chiu, GY
Li, HL
del Rio-Navarro, BE
Willis-Owens, SAG
Weiss, ST
Raby, BA
Gao, H
Eng, C
Chapeia, R
Burchard, EG
Tang, H
Sullivan, PF
London, SJ
AF Hancock, Dana B.
Romieu, Isabelle
Shi, Min
Sienra-Monge, Juan-Jose
Wu, Hao
Chiu, Grace Y.
Li, Huiling
Estela del Rio-Navarro, Blanca
Willis-Owens, Saffron A. G.
Weiss, Scott T.
Raby, Benjamin A.
Gao, Hong
Eng, Celeste
Chapeia, Rocio
Burchard, Esteban G.
Tang, Hua
Sullivan, Patrick F.
London, Stephanie J.
TI Genome-Wide Association Study Implicates Chromosome 9q21.31 as a
Susceptibility Locus for Asthma in Mexican Children
SO PLOS GENETICS
LA English
DT Article
ID CASE-PARENT TRIADS; LINKAGE DISEQUILIBRIUM; CHILDHOOD ASTHMA;
PUERTO-RICAN; ADMIXTURE; GENES; RUNX3; AMERICAN; HOMOLOGS; PROTEINS
AB Many candidate genes have been studied for asthma, but replication has varied. Novel candidate genes have been identified for various complex diseases using genome-wide association studies (GWASs). We conducted a GWAS in 492 Mexican children with asthma, predominantly atopic by skin prick test, and their parents using the Illumina HumanHap 550 K BeadChip to identify novel genetic variation for childhood asthma. The 520,767 autosomal single nucleotide polymorphisms (SNPs) passing quality control were tested for association with childhood asthma using log-linear regression with a log-additive risk model. Eleven of the most significantly associated GWAS SNPs were tested for replication in an independent study of 177 Mexican case-parent trios with childhood-onset asthma and atopy using log-linear analysis. The chromosome 9q21.31 SNP rs2378383 (p = 7.10 x 10(-6) in the GWAS), located upstream of transducin-like enhancer of split 4 (TLE4), gave a p-value of 0.03 and the same direction and magnitude of association in the replication study (combined p = 6.79 x 10(-7)). Ancestry analysis on chromosome 9q supported an inverse association between the rs2378383 minor allele (G) and childhood asthma. This work identifies chromosome 9q21.31 as a novel susceptibility locus for childhood asthma in Mexicans. Further, analysis of genome-wide expression data in 51 human tissues from the Novartis Research Foundation showed that median GWAS significance levels for SNPs in genes expressed in the lung differed most significantly from genes not expressed in the lung when compared to 50 other tissues, supporting the biological plausibility of our overall GWAS findings and the multigenic etiology of childhood asthma.
C1 [Hancock, Dana B.; London, Stephanie J.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA.
[Romieu, Isabelle] Inst Nacl Salud Publ, Cuernavaca, Morelos, Mexico.
[Shi, Min] Natl Inst Environm Hlth Sci, Biostat Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
[Sienra-Monge, Juan-Jose; Estela del Rio-Navarro, Blanca] Hosp Infantil Mexico Dr Federico Gomez, Mexico City, DF, Mexico.
[Wu, Hao; Li, Huiling; London, Stephanie J.] Natl Inst Environm Hlth Sci, Lab Resp Biol, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
[Chiu, Grace Y.] Westat Corp, Res Triangle Pk, NC USA.
[Willis-Owens, Saffron A. G.] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England.
[Weiss, Scott T.; Raby, Benjamin A.] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA.
[Weiss, Scott T.; Raby, Benjamin A.] Harvard Univ, Sch Med, Boston, MA USA.
[Gao, Hong; Tang, Hua] Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
[Eng, Celeste; Burchard, Esteban G.] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA.
[Chapeia, Rocio] Inst Nacl Enfermedades Resp, Mexico City, DF, Mexico.
[Sullivan, Patrick F.] Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
RP Hancock, DB (reprint author), Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA.
EM london2@niehs.nih.gov
RI Hancock, Dana/D-8577-2012;
OI Hancock, Dana/0000-0003-2240-3604; London, Stephanie/0000-0003-4911-5290
FU Intramural Research Program of the National Institute of Environmental
Health Sciences; National Institutes of Health; Department of Health and
Human Services [Z01ES049019]; National Council of Science and Technology
[26206-M]; National Center for Environmental Health at the Centers for
Disease Control; National Institute of General Medical Services
[GM073059]; National Institutes of Health [HL078885, HL088133, ES015794]
FX This research was supported by the Intramural Research Program of the
National Institute of Environmental Health Sciences, National Institutes
of Health, Department of Health and Human Services (Z01ES049019).
Subject enrollment was supported in part by the National Council of
Science and Technology (grant 26206-M), Mexico. Dr. Romieu was supported
in part by the National Center for Environmental Health at the Centers
for Disease Control. Dr. Tang was supported in part by the National
Institute of General Medical Services grant GM073059. Dr. Burchard
received support from the National Institutes of Health (HL078885,
HL088133, ES015794), Flight Attendant Medical Research Institute
(FAMRI), RWJ Amos Medical Faculty Development Award, and the Sandler
Family Foundation. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 49
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U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1553-7390
J9 PLOS GENET
JI PLoS Genet.
PD AUG
PY 2009
VL 5
IS 8
AR e1000623
DI 10.1371/journal.pgen.1000623
PG 11
WC Genetics & Heredity
SC Genetics & Heredity
GA 516HS
UT WOS:000271533500037
PM 19714205
ER
PT J
AU Bowman, CC
Selgrade, MK
AF Bowman, Christal C.
Selgrade, MaryJane K.
TI Utility of rodent models for evaluating protein allergenicity
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT International Workshop on Current and Future Methods for Evaluating the
Allergenic Potential of Proteins
CY OCT 23-25, 2007
CL Nice, FRANCE
SP Health & Environ Sci Inst, Protein Allergenic Tech Committ
DE Allergenicity; Biotechnology; Food allergy; Oral tolerance;
Digestibility; Genetically modified food; Animal model
ID ORAL SENSITIZATION MODEL; BROWN-NORWAY RATS; CHOLERA-TOXIN; MURINE
MODEL; BRAZIL NUT; ACTIVATION PATTERNS; ANTIBODY-RESPONSES;
IMMUNE-RESPONSES; PEANUT ALLERGENS; SOLUBLE-ANTIGEN
AB Animal models are needed to assess novel proteins produced through biotechnology for potential dietary allergenicity. The exact characteristics that give certain foods allergenic potential are unclear, but must include both the potential to sensitize (induce IgE) as well as the capacity to avoid induction of oral tolerance (specific inhibition of IgE production). EPA has developed two complementary mouse models; one which distinguishes allergenic from non-allergenic food extracts using oral sensitization with adjuvant (cholera toxin) and another which further distinguishes highly potent allergens following oral administration without adjuvant based on the development (or not) of tolerance. For the foods tested thus far (roasted or raw peanut, Brazil nut, egg white, turkey, and spinach), the ability to sensitize and/or tolerize in these models are consistent with observed allergenicity as well as persistence and severity among allergens. Additionally, in vitro pepsin-resistance analysis of these food extracts suggests an association between sensitization capacity and proteins which are stable to gastric digestion. A subcutaneous exposure model did not distinguish allergenic from non-allergenic foods and does not appear useful for assessing potential allergenicity. Published by Elsevier Inc.
C1 [Bowman, Christal C.; Selgrade, MaryJane K.] US EPA, Immunotoxicol Branch, Expt Toxicol Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Bowman, CC (reprint author), US EPA, Immunotoxicol Branch, Expt Toxicol Div, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr,MD B143-01, Res Triangle Pk, NC 27711 USA.
EM bowman.christal@epa.gov
NR 43
TC 8
Z9 9
U1 1
U2 10
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
EI 1096-0295
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD AUG
PY 2009
VL 54
IS 3
SU 1
BP S58
EP S61
DI 10.1016/j.yrtph.2008.10.002
PG 4
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA 476TZ
UT WOS:000268470100012
PM 18957311
ER
PT J
AU Ladics, GS
Selgrade, MK
AF Ladics, Gregory S.
Selgrade, MaryJane K.
TI Identifying food proteins with allergenic potential: Evolution of
approaches to safety assessment and research to provide additional tools
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT International Workshop on Current and Future Methods for Evaluating the
Allergenic Potential of Proteins
CY OCT 23-25, 2007
CL Nice, FRANCE
SP Health & Environ Sci Inst, Protein Allergenic Tech Committ
DE Protein allergenicity; Food safety assessment approaches; Transgenic
proteins; Plant biotechnology; Research approaches
ID GENETICALLY-MODIFIED FOODS; MODIFIED CROPS; ANIMAL-MODELS;
DIGESTIBILITY; PREDICTION; REACTIVITY; SEQUENCE; ISSUES
AB A safety assessment process exists for genetically engineered crops that includes the evaluation of the expressed protein for allergenic potential. The objectives of this evaluation are twofold: (1) to protect allergic consumers from exposure to known allergenic or cross-reactive proteins, and (2) protect the general population from risks associated with the introduction of genes encoding proteins that are likely to become food allergens. The first systematic approach to address these concerns was formulated by Metcalfe et al. [Metcalfe, D.D., Astwood, J.D., Townsend, R., Sampson, H.A., Taylor, S.L, and Fuchs, R-L. 1996. Assessment of the allergenic potential of foods from genetically engineered crop plants. Crit. Rev. Food Sci. Nutr. 36(5), 165-186.] and subsequently Food and Agriculture Organization of the United Nations/World Health Organization (FAO/WHO) [FAO/WHO, 2001. Evaluation of allergenicity of genetically modified foods. Report of a joint FAO/WHO Expert Consultation on Allergenicity of Foods Derived from Biotechnology. January 22-25, 2001. Rome, Italy]. More recently, Codex [Codex Alimentarius Commission, 2003. Alinorm 03/34: joint FAO/WHO Food Standard Programme, Codex Alimentarius Commission, Twenty-Fifth Session, Rome, Italy, 30 June-5 July, 2003. Appendix III, Guideline for the conduct of food safety assessment of foods derived from recombinant-DNA plants, and Appendix IV, Annex on the assessment of possible allergenicity. pp. 47-60], noting that no single factor is recognized as an identifier for protein allergenicity, suggested a weight of evidence approach be conducted that takes into account a variety of factors and approaches for an overall assessment of allergenic potential. These various recommendations are based on what is known about allergens, including the history of exposure and safety of the gene(s) source; amino acid sequence identity to human allergens; stability to pepsin digestion in vitro; protein abundance in the crop and processing effects; and when appropriate, specific IgE binding studies or skin-prick testing. Similarities and differences between these various suggested recommendations, as well as data gaps, are discussed. The US Environmental Protection Agency (EPA)'s Office of Research and Development (ORD) has initiated a targeted research effort to address data gaps and improve the various recommended methods/endpoints for assessing the allergenic risks associated with plant incorporated pesticides (PIPs) through both intramural and extramural (grant supported) research. The areas of primary focus for EPA include: (1) development and evaluation of animal models; (2) targeted or specific serological assays; and (3) structure-activity relationships. Details on the current as well as proposed EPA funded research are discussed. More recently US EPA has partnered with the National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health to support research in areas of mutual interest with respect to food allergy. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Ladics, Gregory S.] DuPont Co Inc, DuPont Crop Genet, Wilmington, DE 19880 USA.
[Selgrade, MaryJane K.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Ladics, GS (reprint author), DuPont Co Inc, DuPont Crop Genet, Wilmington, DE 19880 USA.
EM gregory.s.ladics@usa.dupont.com
NR 31
TC 13
Z9 13
U1 3
U2 21
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD AUG
PY 2009
VL 54
IS 3
BP S2
EP S6
DI 10.1016/j.yrtph.2008.10.010
PG 5
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA 476TZ
UT WOS:000268470100002
PM 19028539
ER
PT J
AU Mukerjee, S
Smith, LA
Johnson, MM
Neas, LM
Stallings, CA
AF Mukerjee, Shaibal
Smith, Luther A.
Johnson, Mary M.
Neas, Lucas M.
Stallings, Casson A.
TI Spatial analysis and land use regression of VOCs and NO2 from
school-based urban air monitoring in Detroit/Dearborn, USA
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Air pollution; GIS; Spatial analysis; Land use regression (LUR); Urban
air quality; Traffic
ID VOLATILE ORGANIC-COMPOUNDS; FINE PARTICULATE MATTER; NITROGEN-DIOXIDE;
SOURCE IDENTIFICATION; AMBIENT AIR; POLLUTION; EXPOSURE; DETROIT;
HEALTH; VARIABILITY
AB Passive ambient air sampling for nitrogen dioxide (NO2) and volatile organic compounds (VOCs) was conducted at 25 school and two compliance sites in Detroit and Dearborn. Michigan, USA during the summer of 2005. Geographic Information System (GIS) data were calculated at each of 116 schools. The 25 selected schools were monitored to assess and model intra-urban gradients of air pollutants to evaluate impact of traffic and urban emissions on pollutant levels. Schools were chosen to be statistically representative of urban land use variables such as distance to major roadways, traffic intensity around the schools, distance to nearest point sources, population density. and distance to nearest border crossing. Two approaches were used to investigate spatial variability. First. Kruskal-Wallis analyses and pairwise comparisons on data from the schools examined coarse spatial differences based on city section and distance from heavily trafficked roads. Secondly, spatial variation on a finer scale and as a response to multiple factors was evaluated through land use regression (LUR) models via multiple linear regression. For weeklong exposures, VOCs did not exhibit spatial variability by city section or distance from major roads; NO2 was significantly elevated in a section dominated by traffic and industrial influence versus a residential section. Somewhat in contrast to coarse spatial,analyses, LUR results revealed spatial gradients in NO2 and selected VOCs across the area. The process used to select spatially representative sites for air sampling and the results of coarse and fine spatial variability of air pollutants provide insights that may guide future air quality studies in assessing intra-urban gradients. Published by Elsevier B.V.
C1 [Mukerjee, Shaibal] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Smith, Luther A.; Stallings, Casson A.] Alion Sci & Technol Inc, Res Triangle Pk, NC 27709 USA.
[Johnson, Mary M.; Neas, Lucas M.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Mukerjee, S (reprint author), US EPA, Natl Exposure Res Lab, E205-03, Res Triangle Pk, NC 27711 USA.
EM mukerjee.shaibal@epa.gov
RI Neas, Lucas/J-9378-2012
FU U.S. Environmental Protection Agency [EP-D-05-065]
FX We thank Hunter Daughtrey, Karen Oliver, Herb Jacumin, Laura Liao, Chris
Fortune, Mike Wheeler, and Dennis Williams, all from Alion Science and
Technology, Felicia Venable and Mathew Sam of the Detroit Public
Schools, Don Ball of Dearborn Public Schools, and principals and staff.
We also thank Mary Ann Heindorf, Ann Chevalier, Deborah Sherrod, Amy
Robinson, and Craig Fitzner for access to MDEQ sites and data and Ron
Williams and Alan Vette of EPA for manuscript review. Finally, we thank
Ann Williams, Gina Andrews, Paul Killough of EPA, and John Archer of
Eastern Research Group for assistance. The US. Environmental Protection
Agency through its Office of Research and Development funded and managed
the research described here under contract EP-D-05-065 to Alion. The
paper has been subjected to Agency review and approved for publication.
NR 44
TC 28
Z9 28
U1 4
U2 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD AUG 1
PY 2009
VL 407
IS 16
BP 4642
EP 4651
DI 10.1016/j.scitotenv.2009.04.030
PG 10
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 468SA
UT WOS:000267839200012
PM 19467697
ER
PT J
AU Keenan, C
Elmore, S
Francke-Carroll, S
Kerlin, R
Peddada, S
Pletcher, J
Rinke, M
Schmidt, SP
Taylor, I
Wolf, DC
AF Keenan, Charlotte
Elmore, Susan
Francke-Carroll, Sabine
Kerlin, Roy
Peddada, Shyamal
Pletcher, John
Rinke, Matthias
Schmidt, Stephen Peter
Taylor, Ian
Wolf, Douglas C.
TI Potential for a Global Historical Control Database for Proliferative
Rodent Lesions
SO TOXICOLOGIC PATHOLOGY
LA English
DT Editorial Material
C1 [Keenan, Charlotte] GlaxoSmithKline Inc, King Of Prussia, PA 19406 USA.
[Elmore, Susan] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA.
[Francke-Carroll, Sabine] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA.
[Pletcher, John] Charles River, Frederick, MD 21701 USA.
[Rinke, Matthias] Bayer Schering Pharma AG, Wuppertal, Germany.
[Kerlin, Roy; Schmidt, Stephen Peter] Pfizer Inc, Groton, CT 06340 USA.
[Taylor, Ian] Huntingdon Life Sci, Eye IP23 7PX, Suffolk, England.
[Wolf, Douglas C.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Keenan, C (reprint author), GlaxoSmithKline Inc, 709 Swedeland Rd,UE0360, King Of Prussia, PA 19406 USA.
EM charlotte.m.keenan@gsk.com
RI Peddada, Shyamal/D-1278-2012
FU Intramural NIH HHS
NR 3
TC 3
Z9 3
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0192-6233
J9 TOXICOL PATHOL
JI Toxicol. Pathol.
PD AUG
PY 2009
VL 37
IS 5
BP 677
EP 678
DI 10.1177/0192623309336155
PG 2
WC Pathology; Toxicology
SC Pathology; Toxicology
GA 476WF
UT WOS:000268476400012
PM 19638441
ER
PT J
AU Keenan, C
Elmore, S
Francke-Carroll, S
Kemp, R
Kerlin, R
Peddada, S
Pletcher, J
Rinke, M
Schmidt, SP
Taylor, I
Wolf, DC
AF Keenan, Charlotte
Elmore, Susan
Francke-Carroll, Sabine
Kemp, Ramon
Kerlin, Roy
Peddada, Shyamal
Pletcher, John
Rinke, Matthias
Schmidt, Stephen Peter
Taylor, Ian
Wolf, Douglas C.
TI Best Practices for Use of Historical Control Data of Proliferative
Rodent Lesions
SO TOXICOLOGIC PATHOLOGY
LA English
DT Editorial Material
DE historical control data; rodent tumors; carcinogenicity studies; best
practices
ID NATIONAL TOXICOLOGY PROGRAM; SPRAGUE-DAWLEY RATS; DUAL CONTROL-GROUPS;
WISTAR RATS; BODY-WEIGHT; SPONTANEOUS TUMORS; B6C3F1 MICE; JOINT
PUBLICATION; REVISED GUIDES; NACAD GROUPS
C1 [Keenan, Charlotte] GlaxoSmithKline Inc, King Of Prussia, PA 19406 USA.
[Elmore, Susan] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA.
[Francke-Carroll, Sabine] US FDA, CFSAN, College Pk, MD USA.
[Kemp, Ramon] Merck Res Labs, Riom, France.
[Kerlin, Roy; Schmidt, Stephen Peter] Pfizer Inc, Groton, CT 06340 USA.
[Pletcher, John] Charles River, Frederick, MD USA.
[Rinke, Matthias] Bayer Schering Pharma AG, Wuppertal, Germany.
[Wolf, Douglas C.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Keenan, C (reprint author), GlaxoSmithKline Inc, 79 Swedeland Rd,UE0360, King Of Prussia, PA 19406 USA.
EM charlotte.m.keenan@gsk.com
RI Peddada, Shyamal/D-1278-2012
FU Intramural NIH HHS
NR 114
TC 43
Z9 44
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0192-6233
J9 TOXICOL PATHOL
JI Toxicol. Pathol.
PD AUG
PY 2009
VL 37
IS 5
BP 679
EP 693
DI 10.1177/0192623309336154
PG 15
WC Pathology; Toxicology
SC Pathology; Toxicology
GA 476WF
UT WOS:000268476400013
PM 19454599
ER
PT J
AU Gray, LE
Barlow, NJ
Howdeshell, KL
Ostby, JS
Furr, JR
Gray, CL
AF Gray, Leon Earl, Jr.
Barlow, Norman J.
Howdeshell, Kembra L.
Ostby, Joseph S.
Furr, Johnathan R.
Gray, Clark L.
TI Transgenerational Effects of Di (2-Ethylhexyl) Phthalate in the Male
CRL:CD(SD) Rat: Added Value of Assessing Multiple Offspring per Litter
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE di(2-ethylhexyl) phthalate; sexual differentiation; phthalate syndrome;
dose response
ID TESTICULAR DYSGENESIS SYNDROME; ALTERS SEXUAL-DIFFERENTIATION; BUTYL
BENZYL PHTHALATE; IN-UTERO EXPOSURE; DI(2-ETHYLHEXYL) PHTHALATE;
LACTATIONAL EXPOSURE; DOSE-RESPONSE; REPRODUCTIVE DEVELOPMENT;
DIETHYLHEXYL PHTHALATE; DI(N-BUTYL) PHTHALATE
AB In the rat, some phthalates alter sexual differentiation at relatively low dosage levels by altering fetal Leydig cell development and hormone synthesis, thereby inducing abnormalities of the testis, gubernacular ligaments, epididymis, and other androgen-dependent tissues. In order to define the dose-response relationship between di(2-ethylhexyl) phthalate (DEHP) and the Phthalate Syndrome of reproductive alterations in F1 male rats, Sprague-Dawley (SD) rat dams were dosed by gavage from gestational day 8 to day 17 of lactation with 0, 11, 33, 100, or 300 mg/kg/day DEHP (71-93 males per dose from 12 to 14 litters per dose). Some of the male offspring continued to be exposed to DEHP via gavage from 18 days of age to necropsy at 63-65 days of age (PUB cohort; 16-20/dose). Remaining males were not exposed after postnatal day 17 (in utero-lactational [IUL] cohort) and were necropsied after reaching full maturity. Anogenital distance, sperm counts and reproductive organ weights were reduced in F1 males in the 300 mg/kg/day group and they displayed retained nipples. In the IUL cohort, seminal vesicle weight also was reduced at 100 mg/kg/day. In contrast, serum testosterone and estradiol levels were unaffected in either the PUB or IUL cohorts at necropsy. A significant percentage of F1 males displayed one or more Phthalate Syndrome lesions at 11 mg/kg/day DEHP and above. We were able to detect effects in the lower dose groups only because we examined all the males in each litter rather than only one male per litter. Power calculations demonstrate how using multiple males versus one male/litter enhances the detection of the effects of DEHP. The results at 11 mg/kg/day confirm those reported from a National Toxicology Program multigenerational study which reported no observed adverse effect levels-lowest observed adverse effect levels of 5 and 10 mg/kg/day DEHP, respectively, via the diet.
C1 [Gray, Leon Earl, Jr.; Howdeshell, Kembra L.; Ostby, Joseph S.; Furr, Johnathan R.] US EPA, Endocrinol Branch, RTD, NHEERL,ORD, Res Triangle Pk, NC 27711 USA.
[Barlow, Norman J.] Sanofi Aventis US Inc, Drug Safety Evaluat, Malvern, PA 19355 USA.
[Gray, Clark L.] Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27516 USA.
RP Gray, LE (reprint author), US EPA, Reprod Toxicol Branch, TAD, NHEERL,ORD,Reprod Toxicol Facil, MD 72,2525 E NC 54, Durham, NC 27713 USA.
EM gray.earl@epa.gov
FU National Science Foundation
FX National Science Foundation to C. L. G.
NR 55
TC 36
Z9 36
U1 2
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD AUG
PY 2009
VL 110
IS 2
BP 411
EP 425
DI 10.1093/toxsci/kfp109
PG 15
WC Toxicology
SC Toxicology
GA 469IM
UT WOS:000267889700015
PM 19482887
ER
PT J
AU Goetz, AK
Dix, DJ
AF Goetz, Amber K.
Dix, David J.
TI Mode of Action for Reproductive and Hepatic Toxicity Inferred from a
Genomic Study of Triazole Antifungals
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE myclobutanil; propiconazole; triadimefon; toxicogenomics; steroid
metabolism
ID PREGNANE-X-RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CONAZOLE
FUNGICIDES; NUCLEAR RECEPTOR; RAT-LIVER; GENE-EXPRESSION;
ACTIVE/ANDROSTANE RECEPTOR; TRANSCRIPTIONAL PROFILES; CYTOCHROME-P450
ENZYMES; NUTRITIONAL REGULATION
AB The mode of action for the reproductive toxicity of some triazole antifungals has been characterized as an increase in serum testosterone and hepatic response, and reduced insemination and fertility indices. In order to refine our mechanistic understanding of these potential modes of action, gene expression profiling was conducted on liver and testis from male Wistar Han IGS rats exposed to myclobutanil (500, 2000 ppm), propiconazole (500, 2500 ppm), or triadimefon (500, 1800 ppm) from gestation day six to postnatal day 92. Gene expression profiles indicated that all three triazoles significantly perturbed the fatty acid, steroid, and xenobiotic metabolism pathways in the male rat liver. In addition, triadimefon modulated expression of genes in the liver from the sterol biosynthesis pathway. Although expression of individual genes were affected, there were no common pathways modulated by all three triazoles in the testis. The pathways identified in the liver included numerous genes involved in phase I-III metabolism (Aldh1a1, Cyp1a1, Cyp2b2, Cyp3a1, Cyp3a2, Slco1a4, Udpgtr2), fatty acid metabolism (Cyp4a10, Pcx, Ppap2b), and steroid metabolism (Ugt1a1, Ugt2a1) for which expression was altered by the triazoles. These differentially expressed genes form part of a network involving lipid, sterol, and steroid homeostatic pathways regulated by the constitutive androstane (CAR), pregnane X (PXR), peroxisome proliferator-activated alpha, and other nuclear receptors in liver. These relatively high dose and long-term exposures to triazole antifungals appeared to perturb fatty acid and steroid metabolism in the male rat liver predominantly through the CAR and PXR signaling pathways. These toxicogenomic effects describe a plausible series of key events contributing to the disruption in steroid homeostasis and reproductive toxicity of select triazole antifungals.
C1 [Goetz, Amber K.; Dix, David J.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Goetz, Amber K.] N Carolina State Univ, Dept Environm & Mol Toxicol, Raleigh, NC 27695 USA.
RP Dix, DJ (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Mail Drop D343-03, Res Triangle Pk, NC 27711 USA.
EM dix.david@epa.gov
RI Moreira, Eder/B-2309-2010
FU EPA/North Carolina State University Cooperative Training Agreement
[CT826512010]
FX EPA/North Carolina State University Cooperative Training Agreement
(#CT826512010) supported A.K.G.
NR 59
TC 32
Z9 37
U1 3
U2 21
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD AUG
PY 2009
VL 110
IS 2
BP 449
EP 462
DI 10.1093/toxsci/kfp098
PG 14
WC Toxicology
SC Toxicology
GA 469IM
UT WOS:000267889700018
PM 19423681
ER
PT J
AU McKinney, RA
Charpentier, MA
AF McKinney, Richard A.
Charpentier, Michael A.
TI Extent, properties, and landscape setting of geographically isolated
wetlands in urban southern New England watersheds
SO WETLANDS ECOLOGY AND MANAGEMENT
LA English
DT Article
DE Clean Water Act; Geographically isolated wetlands; Landscape setting;
Urbanization; Watershed
ID POND-BREEDING AMPHIBIANS; ADJACENT LAND-USE; UNITED-STATES; COMMUNITY
COMPOSITION; SPECIES RICHNESS; COASTAL-PLAIN; HABITAT; CONSERVATION;
FRAGMENTATION; CONSEQUENCES
AB We assessed the extent and characteristics of geographically isolated wetlands (i.e., wetlands completely surrounded by upland) in a series of watersheds in the urban northeast US. We applied a previously developed index of urbanization to a sample of 10 watersheds selected at random from a set of 30 watersheds whose boundaries lay within the borders of Rhode Island, USA. The index of urbanization in our sample watersheds ranged over more than an order of magnitude and increased with increasing amount of urban land use in the watersheds (r (2) = 0.51, F = 8.22, P = 0.02). The density of isolated wetlands in the watersheds averaged 1.93 +/- A 0.21 wetlands km(-2) and comprised 38.2 +/- A 1.77% of all wetlands. Isolated wetlands were smaller than those connected to other waters (non-isolated), and accounted for 6.01-16.5% of the total wetland area in the watersheds. The area of isolated wetlands as a percent of all wetland area significantly increased with increasing watershed urbanization (r (2) = 0.62, F = 12.9, P = 0.007). Isolated wetlands were predominantly deciduous forested wetlands, and urban land cover in the 50 m buffer surrounding isolated wetlands was significantly higher than in the 50 m surrounding non-isolated wetlands. The proportion of urban land cover was greater in a 150 than a 50 m buffer surrounding the wetlands. Our results suggest that an increase in the index of urbanization of 50 will result in 7% of the watershed's wetlands being lost from federal protection. These findings indicate that the process of urbanization, along with accompanying habitat fragmentation, may result in an increase in the vulnerability of wetlands to loss and degradation and therefore has implications for the management and conservation of geographically isolated wetlands.
C1 [McKinney, Richard A.] US EPA, Atlantic Ecol Div, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Narragansett, RI 02882 USA.
[Charpentier, Michael A.] Comp Sci Corp, Narragansett, RI 02882 USA.
RP McKinney, RA (reprint author), US EPA, Atlantic Ecol Div, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM mckinney.rick@epa.gov
FU US Environmental Protection Agency
FX We thank Erica Sachs for her efforts to assess the error in remote
sensing data, and Frank Golet for providing information and insights
into state wetlands regulations. We also thank Dennis Skidds, Jeff
Hollister, and Anne Kuhn for providing helpful comments on the
manuscript. Mention of trade names or commercial products does not
constitute endorsement or recommendation. Although the research
described in this article has been funded wholly by the US Environmental
Protection Agency, it has not been subjected to Agency-level review.
Therefore, it does not necessarily reflect the views of the Agency. This
is the Office of Research and Development, National Health and
Environmental Effects Research Laboratory, Atlantic Ecology Division
contribution number AED-07-030. The research described in this article
has been funded wholly by the US Environmental Protection Agency;
however, it does not necessarily reflect the views of the Agency. This
is the Office of Research and Development, National Health and
Environmental Effects Research Laboratory, Atlantic Ecology Division
contribution number AED-07-030.
NR 47
TC 6
Z9 6
U1 3
U2 24
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0923-4861
J9 WETL ECOL MANAG
JI Wetl. Ecol. Manag.
PD AUG
PY 2009
VL 17
IS 4
BP 331
EP 344
DI 10.1007/s11273-008-9110-x
PG 14
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA 462PR
UT WOS:000267368600005
ER
PT J
AU Wilczak, JM
Djalalova, I
McKeen, S
Bianco, L
Bao, JW
Grell, G
Peckham, S
Mathur, R
McQueen, J
Lee, P
AF Wilczak, James M.
Djalalova, Irina
McKeen, Stuart
Bianco, Laura
Bao, Jian-Wen
Grell, Georg
Peckham, Steven
Mathur, Rohit
McQueen, Jeff
Lee, Pius
TI Analysis of regional meteorology and surface ozone during the TexAQS II
field program and an evaluation of the NMM-CMAQ and WRF-Chem air quality
models
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
ID EMISSIONS; HOUSTON; SYSTEM
AB This study examines meteorological conditions associated with regional surface ozone using data collected during the summer Second Texas Air Quality Experiment, and the ability of the Nonhydrostatic Mesoscale Model-Community Multi-scale Air Quality Model (NMM-CMAQ) and the Weather Research and Forecast (WRF) model coupled with Chemistry (WRF-Chem) models to simulate the observed meteorology and surface ozone. The surface ozone data consist of 118 sites that are part of the U. S. Environmental Protection Agency Aerometric Information Retrieval Now (AIRNow) network, while the meteorological data came from a network of eleven 915-MHz wind profilers with RASS temperatures and supporting surface meteorological stations. High and low 8-h maximum ozone occurrences most frequently develop as regional events, with similar ozone concentration patterns across all of east Texas, allowing for a separate analysis of high- and low-ozone day conditions. The ability of the NMM-CMAQ and WRF-Chem models to simulate the meteorologically distinct high- and low-ozone events is analyzed. Histograms of surface ozone show that both the NMM-CMAQ and WRF-Chem models underpredict the full range found in the observations. For low ozone values, the analysis indicates that the models have a positive bias because of too large of an ozone inflow boundary condition value over the Gulf of Mexico. In contrast, the models have a negative bias for very high ozone values that occur mostly in Houston and Dallas, which suggests that the urban emissions and/or chemistry is misrepresented in the models.
C1 [Wilczak, James M.; Djalalova, Irina; McKeen, Stuart; Bianco, Laura; Bao, Jian-Wen; Grell, Georg; Peckham, Steven] Natl Ocean & Atmospher Adm, Earth Syst Res Lab, Boulder, CO 80305 USA.
[Djalalova, Irina; McKeen, Stuart; Bianco, Laura; Grell, Georg; Peckham, Steven] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA.
[McQueen, Jeff; Lee, Pius] Natl Ocean & Atmospher Adm, Natl Ctr Environm Predict, Camp Springs, MD 20746 USA.
[Mathur, Rohit] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27709 USA.
RP Wilczak, JM (reprint author), Natl Ocean & Atmospher Adm, Earth Syst Res Lab, Boulder, CO 80305 USA.
EM james.m.wilczak@noaa.gov
RI Lee, Pius/D-5201-2016; McKeen, Stuart/H-9516-2013; grell,
georg/B-6234-2015
OI grell, georg/0000-0001-5214-8742
FU NOAA's Health of the Atmosphere program; U. S. Environmental Protection
Agency
FX We wish to thank Bryan Lambeth and the Texas Commission on Environmental
Quality, Clinton MacDonald and Charley Knoderer from Sonoma Technology
Inc., Allen White from NOAA's Earth System Research Laboratory/Physical
Science Division, and Wayne Angevine from NOAA's Earth System Research
Laboratory/Chemical Science Division for generously providing the wind
profiler data used in this analysis. We also thank John Nielsen-Gammon
and two anonymous reviewers for their constructive comments. Partial
funding for this research was provided by NOAA's Health of the
Atmosphere program. The U. S. Environmental Protection Agency through
its Office of Research and Development collaborated in the research
described here. It has been subjected to Agency review and approved for
publication.
NR 28
TC 18
Z9 18
U1 1
U2 15
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD JUL 30
PY 2009
VL 114
AR D00F14
DI 10.1029/2008JD011675
PG 22
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 479AT
UT WOS:000268631800001
ER
PT J
AU Huang, YCT
Ghio, AJ
AF Huang, Yuh-Chin T.
Ghio, Andrew J.
TI Controlled human exposures to ambient pollutant particles in susceptible
populations
SO ENVIRONMENTAL HEALTH
LA English
DT Article
ID PARTICULATE AIR-POLLUTION; HEART-RATE-VARIABILITY; OBSTRUCTIVE
PULMONARY-DISEASE; DIESEL-EXHAUST INHALATION; SOUTHERN CALIFORNIA
CHILDREN; LUNG-FUNCTION GROWTH; LONG-TERM EXPOSURE; ULTRAFINE PARTICLES;
HOSPITAL ADMISSIONS; FINE PARTICLES
AB Epidemiologic studies have established an association between exposures to air pollution particles and human mortality and morbidity at concentrations of particles currently found in major metropolitan areas. The adverse effects of pollution particles are most prominent in susceptible subjects, including the elderly and patients with cardiopulmonary diseases. Controlled human exposure studies have been used to confirm the causal relationship between pollution particle exposure and adverse health effects. Earlier studies enrolled mostly young healthy subjects and have largely confirmed the capability of particles to cause adverse health effects shown in epidemiological studies. In the last few years, more studies involving susceptible populations have been published. These recent studies in susceptible populations, however, have shown that the adverse responses to particles appear diminished in these susceptible subjects compared to those in healthy subjects. The present paper reviewed and compared control human exposure studies to particles and sought to explain the "unexpected" response to particle exposure in these susceptible populations and make recommendations for future studies. We found that the causes for the discrepant results are likely multifactorial. Factors such as medications, the disease itself, genetic susceptibility, subject selection bias that is intrinsic to many controlled exposure studies and nonspecificity of study endpoints may explain part of the results. Future controlled exposure studies should select endpoints that are more closely related to the pathogenesis of the disease and reflect the severity of particle-induced health effects in the specific populations under investigation. Future studies should also attempt to control for medications and genetic susceptibility. Using a different study design, such as exposing subjects to filtered air and ambient levels of particles, and assessing the improvement in biological endpoints during filtered air exposure, may allow the inclusion of higher risk patients who are likely the main contributors to the increased particle-induced health effects in epidemiological studies.
C1 [Huang, Yuh-Chin T.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
[Ghio, Andrew J.] US EPA, Human Studies Div, Natl Hlth Effects Res Lab, Chapel Hill, NC USA.
RP Huang, YCT (reprint author), Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
EM huang002@mc.duke.edu; ghio.andy@epamail.epa.gov
NR 67
TC 11
Z9 11
U1 1
U2 14
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-069X
J9 ENVIRON HEALTH-GLOB
JI Environ. Health
PD JUL 25
PY 2009
VL 8
AR 33
DI 10.1186/1476-069X-8-33
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 494AK
UT WOS:000269781300001
PM 19630984
ER
PT J
AU Niitsuma, H
Watson, CN
AF Niitsuma, Hiromi
Watson, Charles N., Jr.
TI Bilyjomyia, a new genus of the tribe Macropelopiini from the Holarctic
(Diptera: Chironomidae)
SO ZOOTAXA
LA English
DT Article
DE Diptera; Chironomidae; Tanypodinae; Macropelopiini; Bilyjomyia; new
genus; new species
ID TANYPODINAE DIPTERA
AB The genus Bilyjomyia is erected for Apsectrotanypus algens (Coquillett, 1902) from western North America and B. fontana n. sp. from Japan. A generic diagnosis and a description are given for all life stages. Bilyjomyia algens is redescribed. All life stages of Bilyjomyia fontana are described and figured. The new genus shows affinities to Macropelopia Thienemann and Bethbilbeckia Fittkau et Murray in the immature stages. Bilyjomyia can be distinguished from all other known Macropelopiini by the following features: the reduced setation of T.IX and the restriction of these setae to the tergal posterior edge in the adult male; the aeropyles of the thoracic horn in the pupa; the labral sclerite and the position and form of the ventral cephalic setae in the larva. The distribution of Bilyjomyia indicates dispersal across the Bering Land Bridge, a pattern known in some other genera of Chironomidae and other orders of insects.
C1 [Watson, Charles N., Jr.] US EPA, Dynamac Corp, Cincinnati, OH 45268 USA.
[Niitsuma, Hiromi] Shizuoka Univ, Fac Educ, Dept Biol, Suruga Ku, Shizuoka 4228529, Japan.
RP Watson, CN (reprint author), US EPA, Dynamac Corp, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM edhniit@ipc.shizuoka.ac.jp; procladius@aol.com
NR 29
TC 3
Z9 3
U1 1
U2 1
PU MAGNOLIA PRESS
PI AUCKLAND
PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND
SN 1175-5326
EI 1175-5334
J9 ZOOTAXA
JI Zootaxa
PD JUL 23
PY 2009
IS 2166
BP 57
EP 68
PG 12
WC Zoology
SC Zoology
GA 474XO
UT WOS:000268318400005
ER
PT J
AU Weinberg, CR
AF Weinberg, Clarice R.
TI HPV Screening for Cervical Cancer in Rural India
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Letter
C1 Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA.
RP Weinberg, CR (reprint author), Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA.
FU Intramural NIH HHS [Z01 ES040006-11]
NR 1
TC 4
Z9 5
U1 0
U2 0
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD JUL 16
PY 2009
VL 361
IS 3
BP 305
EP 306
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 470LL
UT WOS:000267976100020
PM 19610159
ER
PT J
AU Heaney, CD
Sams, E
Wing, S
Marshall, S
Brenner, K
Dufour, AP
Wade, TJ
AF Heaney, Christopher D.
Sams, Elizabeth
Wing, Steve
Marshall, Steve
Brenner, Kristen
Dufour, Alfred P.
Wade, Timothy J.
TI Contact With Beach Sand Among Beachgoers and Risk of Illness
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE bathing beaches; diarrhea; disease transmission; infectious;
environmental pollution; fomites; fresh water; oceans and seas; sewage
ID RECREATIONAL WATER-QUALITY; FECAL INDICATOR ORGANISMS; ESCHERICHIA-COLI;
LAKE-MICHIGAN; NEARSHORE WATER; SOUTH FLORIDA; BACTERIA; MARINE;
PERSISTENCE; ENVIRONMENT
AB Recent studies of beach sand fecal contamination have triggered interest among scientists and in the media. Although evidence shows that beach sand can harbor high concentrations of fecal indicator organisms, as well as fecal pathogens, illness risk associated with beach sand contact is not well understood. Beach visitors at 7 US beaches were enrolled in the National Epidemiological and Environmental Assessment of Recreational Water (NEEAR) Study during 2003-2005 and 2007 and asked about sand contact on the day of their visit to the beach (digging in the sand, body buried in the sand). Then, 10-12 days after their visit, participants were telephoned to answer questions about any health symptoms experienced since the visit. The authors completed 27,365 interviews. Digging in the sand was positively associated with gastrointestinal illness (adjusted incidence proportion ratio (aIPR) = 1.13, 95% confidence interval (CI): 1.02, 1.25) and diarrhea (aIPR = 1.20, 95% CI: 1.05, 1.36). The association was stronger between those buried in the sand and gastrointestinal illness (aIPR = 1.23, 95% CI: 1.05, 1.43) and diarrhea (aIPR = 1.24, 95% CI: 1.01, 1.52). Nonenteric illnesses did not show a consistent association with sand contact activities. Sand contact activities were associated with enteric illness at beach sites. Variation in beach-specific results suggests that site-specific factors may be important in the risk of illness following sand exposure.
C1 [Heaney, Christopher D.; Wing, Steve; Marshall, Steve] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA.
[Heaney, Christopher D.; Sams, Elizabeth; Wade, Timothy J.] US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
[Brenner, Kristen; Dufour, Alfred P.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Heaney, CD (reprint author), Univ N Carolina, Dept Epidemiol, Campus Box 7435, Chapel Hill, NC 27599 USA.
EM cheaney@email.unc.edu
OI Marshall, Stephen/0000-0002-2664-9233
FU US Environmental Protection Agency [CR83323601]; University of North
Carolina
FX Supported by the US Environmental Protection Agency cooperative training
agreement in environmental sciences research (CR83323601) and the
University of North Carolina Department of Environmental Sciences and
Engineering (C. D. H.).
NR 42
TC 62
Z9 62
U1 2
U2 18
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JUL 15
PY 2009
VL 170
IS 2
BP 164
EP 172
DI 10.1093/aje/kwp152
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 469HU
UT WOS:000267887900005
PM 19541858
ER
PT J
AU Huling, SG
Kan, E
Wingo, C
AF Huling, Scott G.
Kan, Eunsung
Wingo, Caleb
TI Fenton-driven regeneration of MTBE-spent granular activated
carbon-Effects of particle size and iron amendment procedures
SO APPLIED CATALYSIS B-ENVIRONMENTAL
LA English
DT Article
DE Activated carbon; Hydrogen peroxide; Iron; Methyl-tert-butyl ether;
Oxidation
ID ORGANIC-COMPOUNDS; HYDROGEN-PEROXIDE; OXIDATION; ADSORPTION;
DECOMPOSITION; REAGENT; WATER; OXIDE; GAC
AB Fenton-driven regeneration of spent granular activated carbon (GAC) can be used to regenerate organic contaminant-spent GAC. In this study, the effects of GAC particle size (>2 mm to <035 mm) and acid pre-treatment of GAC on Fenton-driven oxidation of methyl-tert-butyl ether (MTBE)-spent GAC were evaluated. Iron (Fe) was amended to the GAC using two methods: (1) untreated-where GAC was amended with a concentrated solution of ferrous sulfate and (2) acid pre-treatment-where GAC was amended with acid followed by sequential applications of a dilute ferrous sulfate solution. Subsequently, MTBE was amended to the GAC, followed by oxidative treatments with H(2)O(2). H(2)O(2) reaction and MTBE oxidation were inversely correlated with GAC particle size and were attributed to shorter intraparticle diffusion transport distances for both H(2)O(2) and MTBE. Image analysis of the GAC cross-sections (i.e., prepared thin sections) revealed that the Fe amended to the GAC extended to the center of the GAC particles. Fe accumulated at higher levels on the periphery of the untreated GAC but Fe dispersal was more uniform in the acid pre-treated GAC. In the acid pre-treated GAC, conditions for MTBE oxidation were favorable and greater levels of MTBE oxidation were measured for all particle size fractions tested. Modeling and critical analysis of H(2)O(2) diffusive transport and reaction indicated limited H(2)O(2) penetration into large GAC particles which contributed to a decline in MTBE removal. Residual MTBE remaining on the GAC limited the quantity of MTBE that could be re-adsorbed, but no reduction in MTBE sorption capacity resulted from oxidative treatments. Published by Elsevier B.V.
C1 [Huling, Scott G.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Robert S Kerr Environm Res Ctr, Ada, OK 74820 USA.
[Kan, Eunsung] United Arab Emirates Univ, Dept Chem & Petr Engn, Al Ain, U Arab Emirates.
[Wingo, Caleb] E Cent Univ, Coll Hlth & Sci, Ada, OK 74820 USA.
RP Huling, SG (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Robert S Kerr Environm Res Ctr, POB 1198, Ada, OK 74820 USA.
EM huling.scott@epa.gov; ekan@uaeu.ac.ae; caljwin@email.ecok.edu
NR 25
TC 23
Z9 25
U1 3
U2 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0926-3373
J9 APPL CATAL B-ENVIRON
JI Appl. Catal. B-Environ.
PD JUL 15
PY 2009
VL 89
IS 3-4
BP 651
EP 658
DI 10.1016/j.apcatb.2009.02.002
PG 8
WC Chemistry, Physical; Engineering, Environmental; Engineering, Chemical
SC Chemistry; Engineering
GA 460QW
UT WOS:000267203200046
ER
PT J
AU Schecter, A
Needham, L
Pavuk, M
Michalek, J
Colacino, J
Ryan, J
Papke, O
Birnbaum, L
AF Schecter, Arnold
Needham, Larry
Pavuk, Marian
Michalek, Joel
Colacino, Justin
Ryan, Jake
Paepke, Olaf
Birnbaum, Linda
TI Agent Orange Exposure, Vietnam War Veterans, and the Risk of Prostate
Cancer
SO CANCER
LA English
DT Letter
ID OPERATION RANCH HAND; AIR-FORCE VETERANS; SOUTHEAST-ASIA; DIOXIN;
2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN; CHEMICALS; TISSUE
C1 [Schecter, Arnold] Univ Texas Dallas, Div Environm & Occupat Hlth Sci & Epidemiol, Sch Publ Hlth, Dallas, TX 75230 USA.
[Needham, Larry] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Pavuk, Marian] Ctr Dis Control & Prevent, Agcy Tox Subst & Dis Registry, Atlanta, GA USA.
[Michalek, Joel] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA.
[Colacino, Justin] Univ Texas Dallas, Div Environm & Occupat Hlth Sci, Sch Publ Hlth, Dallas, TX 75230 USA.
[Ryan, Jake] Hlth Canada, Ottawa, ON K1A 0L2, Canada.
[Paepke, Olaf] Eurofins, Hamburg, Germany.
[Birnbaum, Linda] US EPA, Res Triangle Pk, NC 27711 USA.
RP Schecter, A (reprint author), Univ Texas Dallas, Div Environm & Occupat Hlth Sci & Epidemiol, Sch Publ Hlth, Dallas, TX 75230 USA.
RI Needham, Larry/E-4930-2011
NR 25
TC 7
Z9 8
U1 0
U2 10
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0008-543X
J9 CANCER
JI Cancer
PD JUL 15
PY 2009
VL 115
IS 14
BP 3369
EP 3371
DI 10.1002/cncr.24365
PG 3
WC Oncology
SC Oncology
GA 468JM
UT WOS:000267813700025
PM 19415730
ER
PT J
AU Chung, HM
Deng, WM
Cooper, E
AF Chung, Hui-Min
Deng, Wu-Min
Cooper, Emilie
TI Aph-1 is required to regulate Psn-mediated gamma-secretase activity and
cell survival in Drosophila wing development
SO DEVELOPMENTAL BIOLOGY
LA English
DT Meeting Abstract
CT 68th Annual Meeting of the Society-for-Developmental-Biology
CY JUL 23-27, 2009
CL San Francisco, CA
SP Soc Dev Biol
C1 [Chung, Hui-Min; Cooper, Emilie] Univ W Florida, Dept Biol, Pensacola, FL 32514 USA.
[Deng, Wu-Min] Florida State Univ, Dept Biol Sci, Tallahassee, FL 32306 USA.
[Cooper, Emilie] US EPA, Gulf Ecol Div, Gulf Breeze, FL USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0012-1606
J9 DEV BIOL
JI Dev. Biol.
PD JUL 15
PY 2009
VL 331
IS 2
MA 280
BP 468
EP 468
DI 10.1016/j.ydbio.2009.05.306
PG 1
WC Developmental Biology
SC Developmental Biology
GA 467XW
UT WOS:000267777900302
ER
PT J
AU Kenneke, JF
Mazur, CS
Kellock, KA
Overmyer, JP
AF Kenneke, John F.
Mazur, Christopher S.
Kellock, Kristen A.
Overmyer, Jay P.
TI Mechanistic Approach to Understanding the Toxicity of the Azole
Fungicide Triadimefon to a Nontarget Aquatic Insect and Implications for
Exposure Assessment
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID CHIRONOMUS-TENTANS DIPTERA; CARBONYL REDUCTION; COMAMONAS-TESTOSTERONI;
HEPATIC MICROSOMES; CYTOCHROMES P450; RESISTANCE; METYRAPONE;
EXPRESSION; INDUCTION; ANALOGS
AB Mechanistic and stereoselective based in vitro metabolism assays were utlilized to gain insight into the toxic mode of action of the 1,2,4-triazole fungicide, triadimefon, with black fly (Diptera: Simuliidae) larvae. Based on results from enzyme inhibitor studies, the metabolism of triadimefon in black fly larvae microsomes was found to occur predominantly via an oxidative P450-mediated pathway; triadimenol was formed via the stereoselective reduction of the prochiral carbonyl group of triadimefon. The relatively minor contribution of carbonyll reduction suggests that triadimefon may inhibit ecdysone 20-monooxygenase and disrupt insect molting hormone biosynthesis. 48-h LC50 tests for triadimefon and triadimenol with black fly larvae yielded median values (with 95% confidence intervals) of 6.1 (5.8-6.4) and 22.3 (20.3-24.1) mg/L, respectively. The exposure of black fly larvae to sublethal concentrations of triadimefon resulted in increased microsomal P450 activity and affected the microsomal rates of both triadimefon depletion and triadimenol formation. In contrast to trout black fly larvae produced a higher fraction of the more toxic triadimenol stereoisomers, which may explain in part why triadimefon exhibited a significantly greater toxicity with black fly larvae than trout. These results illustrate that while LC50 tests conducted wit commercial triadimenol would presumably expose each organism to the same relative abundance of the four triadimenol stereoisomers, LC50 tests with triadimefon ultimately expose each organism to a unique set of triadimenol stereoisomers depending upon the organism's stereoselective metabolism.
C1 [Kenneke, John F.; Mazur, Christopher S.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
[Kellock, Kristen A.; Overmyer, Jay P.] Univ Georgia, Dept Entomol, Athens, GA 30602 USA.
RP Kenneke, JF (reprint author), US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
EM kenneke.john@epa.gov
NR 30
TC 16
Z9 16
U1 7
U2 24
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JUL 15
PY 2009
VL 43
IS 14
BP 5507
EP 5513
DI 10.1021/es900351w
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 472NE
UT WOS:000268138000056
PM 19708389
ER
PT J
AU Faustini, JM
Kaufmann, PR
Herlihy, AT
AF Faustini, John M.
Kaufmann, Philip R.
Herlihy, Alan T.
TI Downstream variation in bankfull width of wadeable streams across the
conterminous United States
SO GEOMORPHOLOGY
LA English
DT Article
DE Downstream hydraulic geometry; Bankfull width; Anthropogenic
disturbance; Wadeable streams assessment; United States
ID HYDRAULIC GEOMETRY RELATIONSHIPS; MID-ATLANTIC HIGHLANDS; COARSE WOODY
DEBRIS; BENTHIC MACROINVERTEBRATES; RECURRENCE INTERVALS; NATIONAL
ASSESSMENT; ALLUVIAL CHANNELS; SALMONID HABITAT; RIVER-CONTINUUM;
MOUNTAIN STREAM
AB Bankfull channel width is a fundamental measure of stream size and a key parameter of interest for many applications in hydrology, fluvial geomorphology, and stream ecology. We developed downstream hydraulic geometry relationships for bankfull channel width w as a function of drainage area A, w = alpha A(beta), (DHG(wA)) for nine aggregate ecoregions comprising the conterminous United States using 1588 sites from the U.S. Environmental Protection Agency's National Wadeable Streams Assessment (WSA), including 1152 sites from a randomized probability survey sample. Sampled stream reaches ranged from 1 to 75 m in bankfull width and 1 to 10,000 km(2) in drainage area. The DHG(wA) exponent beta, which expresses the rate at which bankfull stream width scales with drainage area, fell into three distinct clusters ranging from 0.22 to 0.38. Width increases more rapidly with basin area in the humid Eastern Highlands (encompassing the Northern and Southern Appalachians and the Ozark Mountains) and the Upper Midwest (Great Lakes region) than for the West (both mountainous and xeric areas), the southeastern Coastal Plain, and the Northern Plains (the Dakotas and Montana). Stream width increases least rapidly with basin area in the Temperate Plains (combelt) and Southern Plains (Great Prairies) in the heartland. The coefficient of determination (r(2)) was least in the noncoastal plains (0.36-0.41) and greatest in the Appalachians and Upper Midwest (0.68-0.77). DHG(wA) equations differed between streams with dominantly fine bed material (silt/sand) and those with dominantly coarse bed material (gravel/cobble/boulder) in six of the nine analysis regions. Where DHG(wA) equations varied by sediment size, fine-bedded streams were consistently narrower than coarse-bedded streams. Within the Western Mountains ecoregion, where there were sufficient sites to develop DHG(wA) relationships at a finer spatial scale, alpha and beta ranged from 1.23 to 3.79 and 0.23 to 0.40, respectively, with r(2)>0.50 for 10 of 13 subregions (range: 0.36 to 0.92). Enhanced DHG equations incorporating additional data for three landscape variables that can be derived from GIS-mean annual precipitation, elevation, and mean reach slope-significantly improved equation fit and predictive value in several regions, most notably the Western Mountains and the Temperate Plains. Channel width was also related to human disturbance. We examined the influence of human disturbance on channel width using several indices of local and basinwide disturbance. Contrary to our expectations, the data suggest that the dominant response of channel width to human disturbance in the United States is a reduction in bankfull width in streams with greater disturbance, particularly in the Western Mountains (where population density, road density, agricultural land use, and local riparian disturbance were all negatively related to channel width) and in the Appalachians and New England (where urban and agricultural land cover and riparian disturbance were all negatively associated with channel width). (C) 2009 Elsevier B.V. All rights reserved.
C1 [Faustini, John M.; Herlihy, Alan T.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA.
[Kaufmann, Philip R.] US EPA, Corvallis, OR 97333 USA.
RP Faustini, JM (reprint author), Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA.
EM faustini.john@epa.gov; kaufmann.phil@epa.gov; herlihy.alan@epa.gov
RI Faustini, John/A-8378-2009
FU USEPA [831682-01]
FX The research presented in this manuscript was undertaken at the USEPA's
Western Ecology Division of the National Health and Environmental
Effects Laboratory in Corvallis, OF, funded by the USEPA through the
Environmental Monitoring and Assessment Program (EMAP: Cooperative
Agreement CR 831682-01). We thank John VanSickle for advice on
statistical analysis and Colleen Burch-Johnson for GIS assistance. This
manuscript has been subjected to review by the National Health and
Environmental Effects Research Laboratory's Western Ecology Division and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
NR 70
TC 28
Z9 28
U1 1
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-555X
J9 GEOMORPHOLOGY
JI Geomorphology
PD JUL 15
PY 2009
VL 108
IS 3-4
BP 292
EP 311
DI 10.1016/j.geomorph.2009.02.005
PG 20
WC Geography, Physical; Geosciences, Multidisciplinary
SC Physical Geography; Geology
GA 460ID
UT WOS:000267180500014
ER
PT J
AU Schaljo, B
Kratochvill, F
Gratz, N
Sadzak, I
Sauer, I
Hammer, M
Vogl, C
Strobl, B
Muller, M
Blackshear, PJ
Poli, V
Lang, R
Murray, PJ
Kovarik, P
AF Schaljo, Barbara
Kratochvill, Franz
Gratz, Nina
Sadzak, Iwona
Sauer, Ines
Hammer, Michael
Vogl, Claus
Strobl, Birgit
Mueller, Mathias
Blackshear, Perry J.
Poli, Valeria
Lang, Roland
Murray, Peter J.
Kovarik, Pavel
TI Tristetraprolin Is Required for Full Anti-Inflammatory Response of
Murine Macrophages to IL-10
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; DUAL-SPECIFICITY PHOSPHATASE-1; MESSENGER-RNA
STABILITY; TNF-ALPHA PRODUCTION; AU-RICH ELEMENTS; GENE-EXPRESSION;
INFLAMMATORY RESPONSE; CHRONIC ENTEROCOLITIS; MAP KINASE; P38 MAPK
AB IL-10 is essential for inhibiting chronic and acute inflammation by decreasing the amounts of proinflammatory cytokines made by activated macrophages. IL-10 controls proinflammatory cytokine and chemokine production indirectly via the transcription factor Stat3. One of the most physiologically significant IL-10 targets is TNF-alpha, a potent proinflammatory mediator that is the target for multiple anti-TNF-alpha clinical strategies in Crohn's disease and rheumatoid arthritis. The anti-inflammatory effects of IL-10 seem to be mediated by several incompletely understood transcriptional and posttranscriptional mechanisms. In this study, we show that in LPS-activated bone marrow-derived murine macrophages, IL-10 reduces the mRNA and protein levels of TNF-a and IL-1 alpha in part through the RNA destabilizing factor tristetraprolin (TTP). TTP is known for its central role in destabilizing mRNA molecules containing class II AU-rich elements in 3' untranslated regions. We found that IL-10 initiates a Stat3-dependent increase of TTP expression accompanied by a delayed decrease of p38 MAPK activity. The reduction of p38 MAPK activity releases TTP from the p38 MAPK-mediated inhibition, thereby resulting in diminished mRNA and protein levels of proinflammatory cytokines. These findings establish that TTP is required for full responses of bone marrow-derived murine macrophages to IL-10. The Journal of Immunology, 2009, 183: 1197-1206.
C1 [Schaljo, Barbara; Kratochvill, Franz; Gratz, Nina; Sadzak, Iwona; Sauer, Ines; Kovarik, Pavel] Univ Vienna, Max F Perutz Labs, Dept Microbiol & Immunobiol, A-1030 Vienna, Austria.
[Vogl, Claus; Strobl, Birgit; Mueller, Mathias] Univ Vet Med Vienna, Inst Genet & Anim Breeding, Vienna, Austria.
[Strobl, Birgit; Mueller, Mathias] Univ Vet Med Vienna, Univ Ctr Biomodels Austria GmbH, Vienna, Austria.
[Blackshear, Perry J.] Natl Inst Environm Hlth Sci, Neurobiol Lab, Res Triangle Pk, NC 27709 USA.
[Poli, Valeria] Univ Turin, Dept Genet Biol & Biochem, Ctr Mol Biol, Turin, Italy.
[Hammer, Michael; Lang, Roland] Tech Univ Munich, Inst Med Microbiol & Immunol & Hyg, Munich, Germany.
[Hammer, Michael; Lang, Roland] Univ Hosp Erlangen, Inst Microbiol Immunol & Hyg, Erlangen, Germany.
[Murray, Peter J.] St Jude Childrens Hosp, Dept Infect Dis, Memphis, TN 38105 USA.
[Murray, Peter J.] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA.
RP Kovarik, P (reprint author), Univ Vienna, Max F Perutz Labs, Dept Microbiol & Immunobiol, Dr Bohr Gasse 9, A-1030 Vienna, Austria.
EM pavel.kovarik@univie.ac.at
RI Poli, Valeria/A-9215-2012; Lang, Roland/C-3287-2011; Kovarik,
Pavel/D-1184-2014;
OI Poli, Valeria/0000-0002-3739-3966; Kovarik, Pavel/0000-0003-2956-0944;
Strobl, Birgit/0000-0001-5716-3212; Lang, Roland/0000-0003-0502-3677
FU Austrian Science Fund (Fonds zur Forderungder Wissenschaftlichen
Forschung) [SFB F28, P16726-B14]; European Science Foundation [127-B03]
FX This study was supported by Austrian Science Fund (Fonds zur
Forderungder Wissenschaftlichen Forschung) Grants SFB F28 and
P16726-B14, European Science Foundation Grant 127-B03 (to P.K.),
Austrian Science Fund Fonds zur Forderungder Wissenschaftlichen
Forschung Grant SFB F28 and the Austrian Federal Ministry for Science
and Research Grant Bundesministerium fur Wissenschaft and Forschung
GZ200.112/1-V1/1/2004 (to M.M.), National Institutes of Health Grant
A1062921 (to P.J.M.), and Deutsche Forschungsgemcinschaft Grants
Sonderforschungsbereich 576/TP-A11 and LA 1262/4-1 (to R.L.).
NR 54
TC 57
Z9 60
U1 0
U2 3
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD JUL 15
PY 2009
VL 183
IS 2
BP 1197
EP 1206
DI 10.4049/jimmunol.0803883
PG 10
WC Immunology
SC Immunology
GA 468JD
UT WOS:000267812600045
PM 19542371
ER
PT J
AU Simon, KC
Chen, HL
Gao, X
Schwarzschild, MA
Ascherio, A
AF Simon, Kelly Claire
Chen, Honglei
Gao, Xiang
Schwarzschild, Michael A.
Ascherio, Alberto
TI Reproductive Factors, Exogenous Estrogen Use, and Risk of Parkinson's
Disease
SO MOVEMENT DISORDERS
LA English
DT Article
DE Parkinson's disease; estrogen; epidemiology; reproductive factors
ID POSTMENOPAUSAL HORMONE USE; BREAST-CANCER; INDUCED NEUROPROTECTION;
PREMENOPAUSAL WOMEN; CIGARETTE-SMOKING; AGE; GENDER; REPRODUCIBILITY;
PROGESTERONE; CAFFEINE
AB To determine if reproductive factors or exogenous estrogen are associated with risk of Parkinson's disease (PD), we conducted a prospective study with 22 years of follow-up among postmenopausal participants in the Nurses' Health Study. Relative risks (RRs) and 95% confidence intervals (CIs) of PD were estimated from a Cox proportional hazards model adjusting for potential confounders. Risk of PD was not significantly associated with any of the reproductive factors measured or exogenous estrogen use. Use of postmenopausal hormones, however, may modify the associations of smoking and caffeine intake with PD risk. The inverse relation between smoking and PD risk was attenuated among ever users of post-menopausal hormones (P for interaction = 0.05). Similar results were obtained for caffeine (P for interaction = 0.09). In exploratory analyses, women using progestin-only hormones were found to have an increased PD risk, but this result was based on a very small number of cases (n = 4). In this large longitudinal study, we found no evidence of a beneficial effect of exogenous or endogenous estrogens on risk of PD. The use of postmenopausal hormone use may interact with other risk factors, but findings are preliminary and need confirmation in other populations. (C) 2009 Movement Disorder Society
C1 [Simon, Kelly Claire; Gao, Xiang; Ascherio, Alberto] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
[Chen, Honglei] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA.
[Schwarzschild, Michael A.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA.
[Ascherio, Alberto] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
[Ascherio, Alberto] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA.
[Ascherio, Alberto] Harvard Univ, Sch Med, Boston, MA 02115 USA.
RP Simon, KC (reprint author), Harvard Univ, Sch Publ Hlth, Dept Nutr, 665 Huntington Ave,Bldg 2,3rd Floor, Boston, MA 02115 USA.
EM ksimon@hsph.harvard.edu
OI Chen, Honglei/0000-0003-3446-7779
FU NIH/NINDS [ROI NS048517, T32 ES07069-26]; Intramural Research Program of
the National Institute of Environmental Health Sciences, the National
Institute of Health [ZOIES1019]; DOD [W81XWH-091-0881]
FX This work was funded by grant NIH/NINDS ROI NS048517 and training grant
T32 ES07069-26 and was in part supported by the Intramural Research
Program of the National Institute of Environmental Health Sciences, the
National Institute of Health (ZOIES1019) and DOD grant W81XWH-091-0881.
We thank Eilis O'Reilly for technical support. The content is solely the
responsibility of the authors and does not necessarily represent the
official views of the National Institutes of Health.
NR 43
TC 30
Z9 30
U1 0
U2 4
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0885-3185
J9 MOVEMENT DISORD
JI Mov. Disord.
PD JUL 15
PY 2009
VL 24
IS 9
BP 1359
EP 1365
DI 10.1002/mds.22619
PG 7
WC Clinical Neurology
SC Neurosciences & Neurology
GA 478UH
UT WOS:000268613300015
PM 19424986
ER
PT J
AU Garcia-Reyero, N
Kroll, KJ
Liu, L
Orlando, EF
Watanabe, KH
Sepulveda, MS
Villeneuve, DL
Perkins, EJ
Ankley, GT
Denslow, ND
AF Garcia-Reyero, Natalia
Kroll, Kevin J.
Liu, Li
Orlando, Edward F.
Watanabe, Karen H.
Sepulveda, Maria S.
Villeneuve, Daniel L.
Perkins, Edward J.
Ankley, Gerald T.
Denslow, Nancy D.
TI Gene expression responses in male fathead minnows exposed to binary
mixtures of an estrogen and antiestrogen
SO BMC GENOMICS
LA English
DT Article
ID MEDAKA ORYZIAS-LATIPES; ZEBRAFISH DANIO-RERIO; CROAKER
MICROPOGONIAS-UNDULATUS; WASTE-WATER CONTAMINANTS; BREAST-CANCER CELLS;
PIMEPHALES-PROMELAS; ATLANTIC CROAKER; LARGEMOUTH BASS; RECEPTOR-ALPHA;
IN-VITRO
AB Background: Aquatic organisms are continuously exposed to complex mixtures of chemicals, many of which can interfere with their endocrine system, resulting in impaired reproduction, development or survival, among others. In order to analyze the effects and mechanisms of action of estrogen/anti-estrogen mixtures, we exposed male fathead minnows (Pimephales promelas) for 48 hours via the water to 2, 5, 10, and 50 ng 17 alpha-ethinylestradiol (EE(2))/L, 100 ng ZM 189, 154/L (a potent antiestrogen known to block activity of estrogen receptors) or mixtures of 5 or 50 ng EE(2)/L with 100 ng ZM 189,154/L. We analyzed gene expression changes in the gonad, as well as hormone and vitellogenin plasma levels.
Results: Steroidogenesis was down-regulated by EE2 as reflected by the reduced plasma levels of testosterone in the exposed fish and down-regulation of genes in the steroidogenic pathway. Microarray analysis of testis of fathead minnows treated with 5 ng EE(2)/L or with the mixture of 5 ng EE(2)/L and 100 ng ZM 189,154/L indicated that some of the genes whose expression was changed by EE(2) were blocked by ZM 189,154, while others were either not blocked or enhanced by the mixture, generating two distinct expression patterns. Gene ontology and pathway analysis programs were used to determine categories of genes for each expression pattern.
Conclusion: Our results suggest that response to estrogens occurs via multiple mechanisms, including canonical binding to soluble estrogen receptors, membrane estrogen receptors, and other mechanisms that are not blocked by pure antiestrogens.
C1 [Garcia-Reyero, Natalia; Kroll, Kevin J.; Denslow, Nancy D.] Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA.
[Garcia-Reyero, Natalia; Kroll, Kevin J.; Denslow, Nancy D.] Univ Florida, Ctr Environm & Human Toxicol, Gainesville, FL 32611 USA.
[Liu, Li] Univ Florida, ICBR, Gainesville, FL 32611 USA.
[Orlando, Edward F.] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA.
[Watanabe, Karen H.] Oregon Hlth & Sci Univ, Div Environm & Biomol Syst, Beaverton, OR 97006 USA.
[Sepulveda, Maria S.] Purdue Univ, Dept Forestry & Nat Resources, W Lafayette, IN 47907 USA.
[Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, ORD, NHEERL, MED, Duluth, MN 55804 USA.
[Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Denslow, ND (reprint author), Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA.
EM natalia@ccmsi.us; krollk@ufl.edu; liliu@biotech.ufl.edu;
eorlando@umd.edu; watanabe@ebs.ogi.edu; mssepulv@purdue.edu;
Villeneuve.Dan@epamail.epa.gov; Edward.J.Perkins@erdc.usace.army.mil;
Ankley.Gerald@epamail.epa.gov; ndenslow@ufl.edu
RI Sepulveda, Maria/P-3598-2014
FU Environmental Protection Agency STAR [R831848]; Spanish Ministry of
Sciences and Technology [EX-2004-0986]; European Union
FX This work was supported by the Environmental Protection Agency STAR
grant, (R831848) to ND, MS, EO and KW, and by a fellowship from the
Spanish Ministry of Sciences and Technology (EX-2004-0986) co-funded by
the European Union to NGR. We wish to thank Dr. Thomas Hutchinson,
(formerly of AstraZeneca) for the generous gift of ZM189,154. The
research described in this article does not necessarily reflect the
views of the EPA and no official endorsement should be inferred. NDD
holds equity in EcoArray, Inc., a company commercializing the microarray
technology used in this study.
NR 86
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U1 0
U2 25
PU BIOMED CENTRAL LTD
PI LONDON
PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T
4LB, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD JUL 13
PY 2009
VL 10
AR 308
DI 10.1186/1471-2164-10-308
PG 17
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 480RX
UT WOS:000268755600001
PM 19594897
ER
PT J
AU Ellington, JJ
Washington, JW
Evans, JJ
Jenkins, TM
Hafner, SC
Neill, MP
AF Ellington, J. Jackson
Washington, John W.
Evans, John J.
Jenkins, Thomas M.
Hafner, Sarah C.
Neill, Michael P.
TI Analysis of fluorotelomer alcohols in soils: Optimization of extraction
and chromatography
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Fluorotelomer; Perfluorinated; 7:2 sFTOH; GC/MS(PCI); Soil; Sludge
ID PERFLUORINATED CARBOXYLIC-ACIDS; TELOMER-B ALCOHOL; PERFLUOROALKYL
ACIDS; ORGANOCHLORINE PESTICIDES; PERFLUOROOCTANE SULFONATE;
MASS-SPECTROMETRY; SMALL VOLUMES; EXPOSURE; WATER; BIOTRANSFORMATION
AB This article describes the development of an analytical method for the determination of fluorotelomer alcohols (FTOHs) in soil. The sensitive and selective determination of the telomer alcohols was performed by extraction with methyl tert-butyl ether (MTBE) and analysis of the extract using gas chromatography with detection and quantification by mass spectrometry operated in the positive chemical ionization mode. The protonated molecular ion, [M+H](+) and a fragment ion (loss of HF + H(2)O) m/z 38 less than the molecular ion were monitored to identify tentatively FTOHs in MTBE extracts of contaminated soils. The FTOHs were confirmed by treatment of the extract with a silylation reagent and observing the disappearance of the FTOH response and the appearance of peaks attributable to the [M+H](+) ions of the trimethylsilyl derivatives. Mass-labeled FTOHs were used as recovery and matrix internal standards. Recovery experiments on soils shown to be free of endogenous FTOHs at instrument detection limits (IDL) of 16 fg/mu L for 6:2 FTOH, 10 fg/mu L for 8:2 FTOH and 14 fg/mu L for 10:2 FTOH yielded a limit of quantitation (LOQ) of 190, 100, and 160 fg/mu L for 6:2 FTOH, 8:2 FTOH, and 10:2 FTOH, respectively when 3 g samples of soil were extracted with 1 mL MTBE. The levels of the 6:2 FTOH, 8:2 FTOH, and 10:2 FTOH in five soils contaminated with FTOHs by exposure to the laboratory atmosphere during air drying were determined. In these air-dried soils, concentrations of FTOHs ranged from non-detectable to 3600 fg/mu L (0.6 ng/g) of the 6:2 FTOH in the extract of a commercial topsoil. This method was used to determine even and odd numbered FTOHs from 6:2 through 14:2 in soils from fields that had received applications of sewage sludge. Concentrations of FTOHs in these sludge-applied soils ranged as high as 820 ng/g of dry soil for the 10:2 FTOH. Published by Elsevier B.V.
C1 [Ellington, J. Jackson; Washington, John W.; Evans, John J.; Jenkins, Thomas M.; Hafner, Sarah C.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
[Evans, John J.; Jenkins, Thomas M.] Senior Serv Amer Inc, Athens, GA 30605 USA.
[Hafner, Sarah C.] Student Serv Author, Athens, GA 30605 USA.
RP Ellington, JJ (reprint author), US EPA, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM ellington.jackson@epa.gov
FU USEPA/OPPT
FX The authors thank USEPA/OPPT for contributing financially to this
research. We thank Cathy Fehrenbacher, Greg Fritz, Laurence Libelo,
David Lynch, Carolyn Acheson, Bryan Boulanger, Mark Strynar, Shoji
Nakayama and Mary Kaiser for stimulating conversations regarding the
fluorotelomer alcohols.
NR 45
TC 18
Z9 19
U1 5
U2 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0021-9673
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD JUL 10
PY 2009
VL 1216
IS 28
BP 5347
EP 5354
DI 10.1016/j.chroma.2009.05.035
PG 8
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 465CF
UT WOS:000267557800003
PM 19497578
ER
PT J
AU Velders, GJM
Fahey, DW
Daniel, JS
McFarland, M
Andersen, SO
AF Velders, Guus J. M.
Fahey, David W.
Daniel, John S.
McFarland, Mack
Andersen, Stephen O.
TI The large contribution of projected HFC emissions to future climate
forcing
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE HCFC consumption; radiative forcing; scenarios
ID GREENHOUSE-GAS EMISSIONS
AB The consumption and emissions of hydrofluorocarbons (HFCs) are projected to increase substantially in the coming decades in response to regulation of ozone depleting gases under the Montreal Protocol. The projected increases result primarily from sustained growth in demand for refrigeration, air-conditioning (AC) and insulating foam products in developing countries assuming no new regulation of HFC consumption or emissions. New HFC scenarios are presented based on current hydrochlorofluorocarbon (HCFC) consumption in leading applications, patterns of replacements of HCFCs by HFCs in developed countries, and gross domestic product (GDP) growth. Global HFC emissions significantly exceed previous estimates after 2025 with developing country emissions as much as 800% greater than in developed countries in 2050. Global HFC emissions in 2050 are equivalent to 9-19% (CO2-eq. basis) of projected global CO2 emissions in business-as-usual scenarios and contribute a radiative forcing equivalent to that from 6-13 years of CO2 emissions near 2050. This percentage increases to 28-45% compared with projected CO2 emissions in a 450-ppm CO2 stabilization scenario. In a hypothetical scenario based on a global cap followed by 4% annual reductions in consumption, HFC radiative forcing is shown to peak and begin to decline before 2050.
C1 [Velders, Guus J. M.] Netherlands Environm Assessment Agcy, NL-3720 AH Bilthoven, Netherlands.
[Fahey, David W.; Daniel, John S.] Natl Ocean & Atmospher Adm, Earth Syst Res Lab, Boulder, CO 80305 USA.
[McFarland, Mack] DuPont Fluoroprod, Wilmington, DE 19805 USA.
[Andersen, Stephen O.] US EPA, Washington, DC 20460 USA.
RP Velders, GJM (reprint author), Netherlands Environm Assessment Agcy, POB 303, NL-3720 AH Bilthoven, Netherlands.
EM guus.velders@pbl.nl
RI Daniel, John/D-9324-2011; Fahey, David/G-4499-2013; Manager, CSD
Publications/B-2789-2015
OI Fahey, David/0000-0003-1720-0634;
NR 31
TC 114
Z9 117
U1 8
U2 46
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUL 7
PY 2009
VL 106
IS 27
BP 10949
EP 10954
DI 10.1073/pnas.0902817106
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 468DX
UT WOS:000267796100017
PM 19549868
ER
PT J
AU Ghio, AJ
Dailey, LA
Richards, JH
Jang, M
AF Ghio, Andrew J.
Dailey, Lisa A.
Richards, Judy H.
Jang, Myoseon
TI Acid and organic aerosol coatings on magnetic nanoparticles increase
iron concentrations in human airway epithelial cells
SO INHALATION TOXICOLOGY
LA English
DT Article
DE particulate matter; ferritin; oxidants; oxidative stress; sulfuric acid;
magnetic nanoparticle; terpenes
ID PARTICULATE MATTER; HETEROGENEOUS REACTIONS; TRANSCRIPTION FACTORS;
LIPID-PEROXIDATION; SECONDARY AEROSOL; DAILY MORTALITY; UNITED-STATES;
ALPHA-PINENE; INDOOR AIR; PARTICLES
AB Numerous industrial applications for man-made nanoparticles have been proposed. Interactions of nanoparticles with agents in the atmosphere may impact human health. We tested the postulate that in vitro exposures of respiratory epithelial cells to airborne magnetic nanoparticles (MNP; Fe3O4) with and without a secondary organic aerosol (SOA) and an inorganic acid could affect iron homeostasis, oxidative stress, and interleukin (IL)-8 release. Cell iron concentrations were increased after exposures to MNP and values were further elevated with co-exposures to either SOA or inorganic acid. Increased expression of ferritin and elevated levels of RNA for DMT1, proteins for iron storage and transport respectively, followed MNP exposures, but values were significant for only those with co-exposures to inorganic acid and organic aerosols. Cell iron concentration corresponded to a measure of oxidative stress in the airway epithelial cells; MNP with co-exposures to SOA and inorganic acid increased both available metal and indices of oxidant generation. Finally, the release of a proinflammatory cytokine (i.e. IL-8) by the exposed cells similarly increased with cell iron concentration. We conclude that MNP can interact with a SOA and an inorganic acid to present metal in a catalytically reactive state to cultured respiratory cells. This produces an oxidative stress to affect a release of IL-8.
C1 [Ghio, Andrew J.] US EPA, Clin Res Branch, Human Studies Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Dailey, Lisa A.; Richards, Judy H.; Jang, Myoseon] Univ Florida, Dept Environm Engn Sci, Gainesville, FL 32611 USA.
RP Ghio, AJ (reprint author), US EPA, Clin Res Branch, Human Studies Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM Ghio.Andy@epamail.epa.gov
FU National Science Foundation [ATM-0703914]
FX This work was supported by a Grant from the National Science Foundation
(ATM-0703914) to the University of Florida.
NR 56
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Z9 3
U1 0
U2 3
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0895-8378
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD JUL-SEP
PY 2009
VL 21
IS 8-11
BP 659
EP 667
DI 10.1080/08958370802406282
PG 9
WC Toxicology
SC Toxicology
GA 500BC
UT WOS:000270271000001
PM 19558223
ER
PT J
AU Adjalle, KD
Brar, SK
Tyagi, RD
Valero, JR
Surampalli, RY
AF Adjalle, K. D.
Brar, S. K.
Tyagi, R. D.
Valero, J. R.
Surampalli, R. Y.
TI Photostabilization of Bacillus thuringiensis fermented wastewater and
wastewater sludge based biopesticides using additives
SO ACTA TROPICA
LA English
DT Article
DE Bacillus thuringiensis; Entomotoxicity; Secondary sludge; Starch
industry wastewater; UV radiations
ID KURSTAKI; PROTEIN; RECOVERY; SUNLIGHT; DAMAGE; CELLS
AB Photoprotection (against UV-A and UV-B radiations) of the active components of Bacillus thuringiensis var. kurstaki obtained from the fermentation of various culture media was investigated. The culture media comprised: starch industry wastewater; secondary wastewater sludge (non-hydrolyzed and hydrolyzed) and soya (used as a reference). Photoprotection was carried out by using various UV-protection additives, namely, para-aminobenzoic acid, lignosulfonic acid and molasses at different concentrations (0.1%, 0.15% and 0.2%, w/w). In the absence of UV-protection agents, secondary sludge demonstrated natural UV protection with half-lives ranging from 3.25 to 3.4 d. The half-life for soya and starch industry wastewater was 1.9 and 1.8 d, respectively. Para-amino-benzoic acid as a UV-protection agent at 0.20% (w/w) gave excellent UV-protection for soya and starch industry wastewater with half-lives being 5.9 and 7 cl, respectively. Likewise, lignosulfonic acid at 0.20% (w/w) was an effective photostabilizer for hydrolyzed and non-hydrolyzed secondary sludge with half-lives of 7.25 and 8 d, respectively. Hence, when similar concentration of the UV-protection additives was used, photoprotection was higher for the alternative media than the conventional soya medium, validating the technical feasibility of using three additives. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Adjalle, K. D.; Brar, S. K.; Tyagi, R. D.; Valero, J. R.] INRS, ETE, Quebec City, PQ G1K 9A9, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP Tyagi, RD (reprint author), INRS, ETE, 490 Couronne,CP 7500, Quebec City, PQ G1K 9A9, Canada.
EM satinder.brar@ete.inrs.ca; tyagi@ete.inrs.ca
FU Natural Sciences and Engineering Research Council of Canada [A4984,
STP235071]; INRS-ETE; FQRNT (ENC)
FX The authors are sincerely thankful to the Natural Sciences and
Engineering Research Council of Canada (grants A4984, STP235071, Canada
Research Chair), INRS-ETE and FQRNT (ENC) for financial support. The
views and opinions expressed in this article are those of authors. The
authors are also grateful to SOPFIM (Societe de Protection des Foret
contre les insects et maladies) for offering prestigious Smirnoff
scholarship to Kokou Adjalle.
NR 36
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Z9 6
U1 1
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0001-706X
J9 ACTA TROP
JI Acta Trop.
PD JUL
PY 2009
VL 111
IS 1
BP 7
EP 14
DI 10.1016/j.actatropica.2008.11.016
PG 8
WC Parasitology; Tropical Medicine
SC Parasitology; Tropical Medicine
GA 452HQ
UT WOS:000266531400002
PM 19100704
ER
PT J
AU Zhang, YF
El-Sikhry, H
Chaudhary, KR
Batchu, SN
Shayeganpour, A
Jukar, TO
Bradbury, JA
Graves, JP
DeGraff, LM
Myers, P
Rouse, DC
Foley, J
Nyska, A
Zeldin, DC
Seubert, JM
AF Zhang, Yunfang
El-Sikhry, Haitham
Chaudhary, Ketul R.
Batchu, Sri Nagarjun
Shayeganpour, Anooshirvan
Jukar, Taibeh Orujy
Bradbury, J. Alyce
Graves, Joan P.
DeGraff, Laura M.
Myers, Page
Rouse, Douglas C.
Foley, Julie
Nyska, Abraham
Zeldin, Darryl C.
Seubert, John M.
TI Overexpression of CYP2J2 provides protection against doxorubicin-induced
cardiotoxicity
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE cytochrome P-450 2J2; heart; function
ID ANKYRIN REPEAT PROTEIN; INDUCED CARDIAC INJURY; INDUCED HEART-FAILURE;
NECROSIS-FACTOR-ALPHA; INDUCED CELL-DEATH; EPOXYEICOSATRIENOIC ACIDS;
OXIDATIVE STRESS; HUMAN MYOCARDIUM; TRANSGENIC MICE; CARP GENE
AB Zhang Y, El-Sikhry H, Chaudhary KR, Batchu SN, Shayeganpour A, Jukar TO, Bradbury JA, Graves JP, DeGraff LM, Myers P, Rouse DC, Foley J, Nyska A, Zeldin DC, Seubert JM. Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol 297: H37-H46, 2009. First published May 8, 2009; doi:10.1152/ajpheart.00983.2008.-Human cytochrome P-450 (CYP)2J2 is abundant in heart and active in biosynthesis of epoxyeicosatrienoic acids (EETs). Recently, we demonstrated that these eicosanoid products protect myocardium from ischemia-reperfusion injury. The present study utilized transgenic (Tr) mice with cardiomyocyte-specific overexpression of human CYP2J2 to investigate protection toward toxicity resulting from acute (0, 5, or 15 mg/kg daily for 3 days, followed by 24-h recovery) or chronic (0, 1.5, or 3.0 mg/kg biweekly for 5 wk, followed by 2-wk recovery) doxorubicin (Dox) administration. Acute treatment resulted in marked elevations of serum lactate dehydrogenase and creatine kinase levels that were significantly greater in wild-type (WT) than CYP2J2 Tr mice. Acute treatment also resulted in less activation of stress response enzymes in CYP2J2 Tr mice (catalase 750% vs. 300% of baseline, caspase- 3 235% vs. 165% of baseline in WT vs. CYP2J2 Tr mice). Moreover, CYP2J2 Tr hearts exhibited less Dox-induced cardiomyocytes apoptosis (measured by TUNEL) compared with WT hearts. After chronic treatment, comparable decreases in body weight were observed in WT and CYP2J2 Tr mice. However, cardiac function, assessed by measurement of fractional shortening with M-mode transthoracic echocardiography, was significantly higher in CYP2J2 Tr than WT hearts after chronic Dox treatment (WT 37 +/- 2%, CYP2J2 Tr 47 +/- 1%). WT mice also had larger increases in beta-myosin heavy chain and cardiac ankryin repeat protein compared with CYP2J2 Tr mice. CYP2J2 Tr hearts had a significantly higher rate of Dox metabolism than WT hearts (2.2 +/- 0.25 vs. 1.6 +/- 0.50 ng.min(-1).100 mu g protein(-1)). In vitro data from H9c2 cells demonstrated that EETs attenuated Dox-induced mitochondrial damage. Together, these data suggest that cardiac-specific overexpression of CYP2J2 limited Dox-induced toxicity.
C1 [Zhang, Yunfang; El-Sikhry, Haitham; Chaudhary, Ketul R.; Batchu, Sri Nagarjun; Shayeganpour, Anooshirvan; Jukar, Taibeh Orujy; Seubert, John M.] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada.
[Graves, Joan P.; DeGraff, Laura M.; Myers, Page; Rouse, Douglas C.; Foley, Julie; Nyska, Abraham; Zeldin, Darryl C.] Natl Inst Environm Hlth Sci, Div Intramural Res, NIH, Res Triangle Pk, NC USA.
[Nyska, Abraham] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
[Rouse, Douglas C.] Duke Univ, Med Ctr, Durham, NC USA.
RP Seubert, JM (reprint author), Univ Alberta, Fac Pharm & Pharmaceut Sci, 3126 Dent Pharm Ctr, Edmonton, AB T6G 2N8, Canada.
EM jseubert@pharmacy.ualberta.ca
FU Canadian Institutes of Health Research [MOP79465]; Intramural Research
Program of the National Institute of Environmental Health Sciences
[Z01-ES-025034]; Heart and Stroke Foundation of Canada; Alberta Heritage
Foundation for Medical Research
FX This work was supported by a Canadian Institutes of Health Research
Grant (MOP79465, J. M. Seubert) and by the Intramural Research Program
of the National Institute of Environmental Health Sciences
(Z01-ES-025034). J. M. Seubert is the recipient of a New Investigator
Award from the Heart and Stroke Foundation of Canada and a Health
Scholar Award from the Alberta Heritage Foundation for Medical Research.
NR 65
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U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUL
PY 2009
VL 297
IS 1
BP H37
EP H46
DI 10.1152/ajpheart.00983.2008
PG 10
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
Disease
SC Cardiovascular System & Cardiology; Physiology
GA 464GI
UT WOS:000267492900007
PM 19429816
ER
PT J
AU Voynow, JA
Fischer, BM
Zheng, S
Potts, EN
Grover, AR
Jaiswal, AK
Ghio, AJ
Foster, WM
AF Voynow, Judith A.
Fischer, Bernard M.
Zheng, Shuo
Potts, Erin N.
Grover, Amy R.
Jaiswal, Anil K.
Ghio, Andrew J.
Foster, W. Michael
TI NAD(P)H Quinone Oxidoreductase 1 Is Essential for Ozone-Induced
Oxidative Stress in Mice and Humans
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Article
DE ozone; NAD(P)H quinone oxidoreductase 1; F(2)-isoprostane
ID LIPID OZONATION PRODUCTS; AIRWAY EPITHELIAL-CELLS; NAD(P)H-QUINONE
OXIDOREDUCTASE-1; ANTIOXIDANT SUPPLEMENTATION; BRONCHIAL REACTIVITY;
INDUCED INFLAMMATION; ASTHMATIC-CHILDREN; CHILDHOOD ASTHMA;
DT-DIAPHORASE; LUNG INJURY
AB One host susceptibility factor for ozone identified in epidemiologic studies is NAD(P)H quinone oxidoreductase 1 (NQO1). We hypothesized that after ozone exposure, NQO1 is required to increase 8-isoprostane (also known as F(2)-isoprostane) production, a recognized marker of ozone-induced oxidative stress, and to enhance airway inflammation and hyperresponsiveness. In this report, we demonstrate that in contrast to wild-type mice, NQO1-null mice are resistant to ozone and have blunted responses, including decreased production of F(2)-isoprostane and keratinocyte chemokine, decreased airway inflammation, and diminished airway hyperreponsiveness. Importantly, these results in mice correlate with in vitro findings in humans. In primary human airway epithelial cells, inhibition of NQO1 by dicumarol blocks ozone-induced F(2)-isoprostane production and IL-8 gene expression. Together, these results demonstrate that NQO1 modulates cellular redox status and influences the biologic and physiologic effects of ozone.
C1 [Voynow, Judith A.] Duke Univ, Med Ctr, Div Pediat Pulm Med, Dept Pediat, Durham, NC 27710 USA.
[Potts, Erin N.; Foster, W. Michael] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
[Jaiswal, Anil K.] Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA.
[Ghio, Andrew J.] US EPA, Natl Hlth & Environm Effects Res Lab, Human Studies Div, Res Triangle Pk, NC 27711 USA.
RP Voynow, JA (reprint author), Duke Univ, Med Ctr, Div Pediat Pulm Med, Dept Pediat, Box 2994, Durham, NC 27710 USA.
EM voyno001@mc.duke.edu
FU National Institutes of Health [HL082504, HL081763, ES07943, ES011961,
ES012496]
FX This work was supported by National Institutes of Health grants HL082504
(J.A.V.), HL081763 (B.M.F.), ES07943 (A.K.J.), ES011961, and ES012496
(W.M.F.).
NR 52
TC 28
Z9 31
U1 0
U2 2
PU AMER THORACIC SOC
PI NEW YORK
PA 1740 BROADWAY, NEW YORK, NY 10019-4374 USA
SN 1044-1549
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD JUL
PY 2009
VL 41
IS 1
BP 107
EP 113
DI 10.1165/rcmb.2008-0381OC
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA 461YA
UT WOS:000267309000015
PM 19059883
ER
PT J
AU Clabby, C
Huber, A
AF Clabby, Catherine
Huber, Alan
TI Follow the Flow
SO AMERICAN SCIENTIST
LA English
DT Editorial Material
C1 [Huber, Alan] US EPA, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SIGMA XI-SCI RES SOC
PI RES TRIANGLE PK
PA PO BOX 13975, RES TRIANGLE PK, NC 27709 USA
SN 0003-0996
J9 AM SCI
JI Am. Scientist
PD JUL-AUG
PY 2009
VL 97
IS 4
BP 326
EP 327
PG 2
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 456LF
UT WOS:000266847100024
ER
PT J
AU Fang, F
Kamel, F
Lichtenstein, P
Bellocco, R
Sparen, P
Sandler, DP
Ye, WM
AF Fang, Fang
Kamel, Freya
Lichtenstein, Paul
Bellocco, Rino
Sparen, Par
Sandler, Dale P.
Ye, Weimin
TI Familial Aggregation of Amyotrophic Lateral Sclerosis
SO ANNALS OF NEUROLOGY
LA English
DT Article
ID SUPEROXIDE-DISMUTASE; PARKINSONS-DISEASE; SOD1 MUTATION; IDENTIFICATION;
PATIENT; RISK; TWIN; ALS
AB Objective: To assess the relative risk for amyotrophic lateral sclerosis (ALS) in families of ALS patients.
Methods: We conducted a cohort study based on the Swedish Multi-Generation Register in 1961 to 2005. Among 6,671 probands (first ALS case in the family), 1,909 full siblings, 13,947 children, and 5,405 spouses were identified (exposed group). Other persons in the Multi-Generation Register, who were siblings, children, or spouses to persons without ALS, served as the reference group. Relative risks for ALS among the exposed group, compared with the reference group, were calculated from Poisson regression models. Concurrence of ALS within twins was assessed in 86,441 twin pairs registered in the Swedish Twin Register.
Results: Nine cases of ALS were noted among the siblings and 37 cases among the children of the probands, giving a 17-fold risk among the siblings (95% confidence interval, 8.1-30.4) and a 9-fold risk among the children (95% confidence interval, 6.2-12.0), compared with the reference group. Siblings and children had a greater excess risk if the proband was diagnosed at a younger age, and the excess risks decreased with increasing age at diagnosis of the proband (p < 0.001). Spouses had no significantly increased risk (p = 0.27). Two cases were identified among the cotwins of ALS probands, giving a relative risk of 32 (95% confidence interval, 5.2-102.6).
Interpretation: The siblings and children of ALS patients have an about 10-fold risk for ALS compared with the reference group. The excess risks vary with both age and kinship, indicating a major genetic role in familial ALS.
C1 [Fang, Fang; Lichtenstein, Paul; Bellocco, Rino; Sparen, Par; Ye, Weimin] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden.
[Fang, Fang; Kamel, Freya; Sandler, Dale P.] Natl Inst Environm Hlth Sci, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
[Bellocco, Rino] Univ Milano Bicocca, Dept Stat, Milan, Italy.
RP Fang, F (reprint author), Karolinska Inst, Dept Med Epidemiol & Biostat, POB 281, S-17177 Stockholm, Sweden.
EM fang.fang@ki.se
RI Ye, Weimin/A-5939-2008;
OI lichtenstein, paul/0000-0003-3037-5287; Fang, Fang/0000-0002-3310-6456;
Kamel, Freya/0000-0001-5052-6615; Sandler, Dale/0000-0002-6776-0018
FU Intramural NIH HHS [NIH0013887932, Z01 ES049005-16]; NIEHS NIH HHS [201
ES49005-15]
NR 21
TC 27
Z9 27
U1 0
U2 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0364-5134
J9 ANN NEUROL
JI Ann. Neurol.
PD JUL
PY 2009
VL 66
IS 1
BP 94
EP 99
DI 10.1002/ana.21580
PG 6
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 481XY
UT WOS:000268847600015
PM 19670447
ER
PT J
AU Estill, CF
Baron, PA
Beard, JK
Hein, MJ
Larsen, LD
Rose, L
Schaefer, FW
Noble-Wang, J
Hodges, L
Lindquist, HDA
Deye, GJ
Arduino, MJ
AF Estill, Cheryl Fairfield
Baron, Paul A.
Beard, Jeremy K.
Hein, Misty J.
Larsen, Lloyd D.
Rose, Laura
Schaefer, Frank W., III
Noble-Wang, Judith
Hodges, Lisa
Lindquist, H. D. Alan
Deye, Gregory J.
Arduino, Matthew J.
TI Recovery Efficiency and Limit of Detection of Aerosolized Bacillus
anthracis Sterne from Environmental Surface Samples
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID NONPOROUS SURFACES; INHALATIONAL ANTHRAX; COLLECTION METHOD;
AUM-SHINRIKYO; SPORES; CONTAMINATION; MAIL
AB After the 2001 anthrax incidents, surface sampling techniques for biological agents were found to be inadequately validated, especially at low surface loadings. We aerosolized Bacillus anthracis Sterne spores within a chamber to achieve very low surface loading (ca. 3, 30, and 200 CFU per 100 cm(2)). Steel and carpet coupons seeded in the chamber were sampled with swab (103 cm(2)) or wipe or vacuum (929 cm(2)) surface sampling methods and analyzed at three laboratories. Agar settle plates (60 cm(2)) were the reference for determining recovery efficiency (RE). The minimum estimated surface concentrations to achieve a 95% response rate based on probit regression were 190, 15, and 44 CFU/100 cm(2) for sampling steel surfaces and 40, 9.2, and 28 CFU/100 cm(2) for sampling carpet surfaces with swab, wipe, and vacuum methods, respectively; however, these results should be cautiously interpreted because of high observed variability. Mean REs at the highest surface loading were 5.0%, 18%, and 3.7% on steel and 12%, 23%, and 4.7% on carpet for the swab, wipe, and vacuum methods, respectively. Precision (coefficient of variation) was poor at the lower surface concentrations but improved with increasing surface concentration. The best precision was obtained with wipe samples on carpet, achieving 38% at the highest surface concentration. The wipe sampling method detected B. anthracis at lower estimated surface concentrations and had higher RE and better precision than the other methods. These results may guide investigators to more meaningfully conduct environmental sampling, quantify contamination levels, and conduct risk assessment for humans.
C1 [Estill, Cheryl Fairfield; Baron, Paul A.; Hein, Misty J.; Deye, Gregory J.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA.
[Beard, Jeremy K.; Larsen, Lloyd D.] Dugway Proving Ground, Dugway, UT 84022 USA.
[Rose, Laura; Noble-Wang, Judith; Hodges, Lisa; Arduino, Matthew J.] Ctr Dis Control & Prevent, Ctr Infect Dis, Atlanta, GA 30333 USA.
[Schaefer, Frank W., III; Lindquist, H. D. Alan] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
RP Estill, CF (reprint author), NIOSH, Ctr Dis Control & Prevent, MS R-14,4676 Columbia Pkwy, Cincinnati, OH 45226 USA.
EM CEstill@cdc.gov
RI Robertson, Simon/D-1549-2012
NR 38
TC 34
Z9 34
U1 0
U2 7
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD JUL 1
PY 2009
VL 75
IS 13
BP 4297
EP 4306
DI 10.1128/AEM.02549-08
PG 10
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 462RI
UT WOS:000267373000009
PM 19429546
ER
PT J
AU Deng, YM
Theken, KN
Edin, ML
Kannon, MA
Schuck, RN
DeGraff, LM
Bradbury, JA
Graves, J
Zeldin, DC
Lee, CR
AF Deng, Yangmei
Theken, Katherine N.
Edin, Matthew L.
Kannon, M. Alison
Schuck, Robert N.
DeGraff, Laura M.
Bradbury, J. Alyce
Graves, Joan
Zeldin, Darryl C.
Lee, Craig R.
TI Endothelial CYP2J2 and CYP2C8 Overexpression and Soluble Epoxide
Hydrolase Deletion Attenuate Acute Inflammatory Responses in Mice
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Meeting Abstract
CT 10th Annual Conference on Arteriosclerosis, Thrombosis and Vascular
Biology
CY APR 29-MAY 01, 2009
CL Washington, DC
SP Amer Heart Assoc, Council Arteriosclerosis, Thrombosis & Vasc Biol
C1 [Deng, Yangmei; Theken, Katherine N.; Kannon, M. Alison; Schuck, Robert N.; Lee, Craig R.] Univ N Carolina, Chapel Hill, NC USA.
[Edin, Matthew L.; DeGraff, Laura M.; Bradbury, J. Alyce; Graves, Joan; Zeldin, Darryl C.] Natl Inst Environm Hlth Sci, Rsch Triangle Pk, NC USA.
RI Theken, Katherine/H-1098-2012
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1079-5642
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD JUL
PY 2009
VL 29
IS 7
BP E63
EP E63
PG 1
WC Hematology; Peripheral Vascular Disease
SC Hematology; Cardiovascular System & Cardiology
GA 459LA
UT WOS:000267102500290
ER
PT J
AU Ghio, AJ
AF Ghio, Andrew J.
TI Disruption of iron homeostasis and lung disease
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
LA English
DT Review
DE Oxidative stress; Ferritin; Divalent metal transporter 1; Transferrin;
Transferrin receptor
ID PULMONARY ALVEOLAR PROTEINOSIS; RESPIRATORY-DISTRESS-SYNDROME;
BONE-MARROW-TRANSPLANTATION; HIGH-DOSE CHEMOTHERAPY; DUODENAL
CYTOCHROME-B; METAL-ION TRANSPORTER; OXIDATIVE STRESS; CYSTIC-FIBROSIS;
DEPENDENT REGULATION; LIPID-PEROXIDATION
AB As a result of a direct exchange with the external environment, the lungs are exposed to both iron and agents with a capacity to disrupt the homeostasis of this metal (e.g. particles). An increased availability of catalytically reactive iron can result from these exposures and, by generating an oxidative stress, this metal can contribute to tissue injury. By importing this Fe(3+) into cells for storage in a chemically less reactive form, the lower respiratory tract demonstrates an ability to mitigate both the oxidative stress presented by iron and its potential for tissue injury. This means that detoxification is accomplished by chemical reduction to Fe(2+) (e.g. by duodenal cytochrome b and other ferrireductases), iron import (e.g. by divalent metal transporter 1 and other transporters), and storage in ferritin. The metal can subsequently be exported from the cell (e.g. by ferroportin 1) in a less reactive state relative to that initially imported. Iron is then transported out of the lung via the mucociliary pathway or blood and lymphatic pathways to the reticuloendothelial system for long term storage. This coordinated handling of iron in the lung appears to be disrupted in several acute diseases on the lung including infections, acute respiratory distress syndrome, transfusion-related acute lung injury, and ischemia-reperfusion. Exposures to bleomycin, dusts and fibers, and paraquat similarly alter iron homeostasis in the lung to affect an oxidative stress. Finally, iron homeostasis is disrupted in numerous chronic lung diseases including pulmonary alveolar proteinosis, transplantation, cigarette smoking, and cystic fibrosis. Published by Elsevier B.V.
C1 US EPA, Human Studies Div, ORD, NHEERL, Chapel Hill, NC 27599 USA.
RP Ghio, AJ (reprint author), US EPA, Human Studies Div, ORD, NHEERL, Campus Box 7315,104 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM ghio.andy@epa.gov
NR 72
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U1 0
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-4165
J9 BBA-GEN SUBJECTS
JI Biochim. Biophys. Acta-Gen. Subj.
PD JUL
PY 2009
VL 1790
IS 7
BP 731
EP 739
DI 10.1016/j.bbagen.2008.11.004
PG 9
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 463XJ
UT WOS:000267467100018
PM 19100311
ER
PT J
AU Connor, JR
Ghio, AJ
AF Connor, James R.
Ghio, Andrew J.
TI The impact of host iron homeostasis on disease Preface
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
LA English
DT Editorial Material
C1 [Connor, James R.] Vet Adm Hosp, Spinal Cord Injury Res Unit, Washington, DC USA.
[Connor, James R.] George Washington Univ, Sch Med, Dept Physiol, Washington, DC 20052 USA.
[Connor, James R.] Penn State Univ, Coll Med, Dept Anat, University Pk, PA 16802 USA.
[Ghio, Andrew J.] Duke Univ, Div Pulm & Crit Care Med, Durham, NC 27706 USA.
[Ghio, Andrew J.] US EPA, Chapel Hill, NC USA.
RP Connor, JR (reprint author), Vet Adm Hosp, Spinal Cord Injury Res Unit, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-4165
J9 BBA-GEN SUBJECTS
JI Biochim. Biophys. Acta-Gen. Subj.
PD JUL
PY 2009
VL 1790
IS 7
DI 10.1016/j.bbagen.2009.05.004
PG 4
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 463XJ
UT WOS:000267467100001
ER
PT J
AU Stierhoff, KL
Targett, TE
Power, JH
AF Stierhoff, Kevin L.
Targett, Timothy E.
Power, James H.
TI Hypoxia-induced growth limitation of juvenile fishes in an estuarine
nursery: assessment of small-scale temporal dynamics using RNA:DNA
SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES
LA English
DT Article
ID COD GADUS-MORHUA; ENERGY ACQUISITION RATES; ASSESS HABITAT QUALITY;
WINTER FLOUNDER; ATLANTIC COD; DNA RATIO; BEHAVIORAL-RESPONSES;
INTRINSIC GROWTH; MENIDIA-MENIDIA; NORTH-CAROLINA
AB The ratio of RNA to DNA (RNA:DNA) in white muscle tissue of juvenile summer flounder (Paralichthys dentatus) and weakfish (Cynoscion regalis) was used as a proxy for recent growth rate in an estuarine nursery. Variability in RNA:DNA was examined relative to temporal changes in temperature and dissolved oxygen (DO). Initial laboratory experiments indicated (i) a strong positive relationship between RNA:DNA and growth rate, (ii) a rapid response of RNA:DNA to changes in feeding, and (iii) no effect of hypoxia on the relationship between RNA:DNA and growth rate (tested in weakfish only). Diel cycling DO occurred in the nursery throughout the summers of 2002 and 2003. Canonical correlation analysis of field data indicated a strong positive relationship between RNA:DNA and mean DO conditions prior to capture in both species. Correlations were weak or insignificant between stomach content mass (an index of feeding) and mean DO and between RNA:DNA and stomach content mass and DO variability. These results suggest a strong functional relationship between DO concentration and the growth rate of juvenile fishes in an estuarine nursery. Furthermore, growth rates of wild-caught fishes (estimated from RNA:DNA) appear to be more negatively impacted by diel cycling hypoxia than would be expected from published laboratory data.
C1 [Stierhoff, Kevin L.; Targett, Timothy E.] Univ Delaware, Coll Marine & Earth Studies, Lewes, DE 19958 USA.
[Power, James H.] US EPA, Hatfield Marine Sci Ctr, Newport, OR 97365 USA.
RP Stierhoff, KL (reprint author), NOAA, SW Fisheries Sci Ctr, Fisheries Resources Div, 8604 La Jolla Shores Dr, La Jolla, CA 92037 USA.
EM kevin.stierhoff@noaa.gov
RI Stierhoff, Kevin/A-7624-2013; Power, James/A-1977-2010
OI Stierhoff, Kevin/0000-0002-3058-0312; Power, James/0000-0001-7745-798X
FU Delaware Sea Grant Program; NOAA; US Department of Commerce
[NA16RG0162-03 (Project R/F-21), NA03OAR4170011 (Project R/F-23)]
FX The authors thank D. Brady, R. Tyler, S. Brown, and D. Tuzzolino for
their assistance throughout this study. We also thank B. Ciotti and E.
Caldarone (NOAA Fisheries) for their valuable insight and support with
the quantification of nucleic acids. We thank P. Gaffney for guidance
with experimental design and statistical analyses. P. Grecay, J. Rice,
and several anonymous reviewers provided useful comments on earlier
drafts of the manuscript. This research was supported by funding from
the Delaware Sea Grant Program, NOAA, US Department of Commerce, under
grant numbers NA16RG0162-03 (Project R/F-21) and NA03OAR4170011 (Project
R/F-23) to T.E.T.
NR 59
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U1 2
U2 18
PU NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS
PI OTTAWA
PA BUILDING M 55, OTTAWA, ON K1A 0R6, CANADA
SN 0706-652X
J9 CAN J FISH AQUAT SCI
JI Can. J. Fish. Aquat. Sci.
PD JUL
PY 2009
VL 66
IS 7
BP 1033
EP 1047
DI 10.1139/F09-066
PG 15
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA 469CY
UT WOS:000267874300003
ER
PT J
AU Spector, D
Mishel, M
Skinner, CS
DeRoo, LA
VanRiper, M
Sandler, DP
AF Spector, Denise
Mishel, Merle
Skinner, Celette Sugg
DeRoo, Lisa A.
VanRiper, Marcia
Sandler, Dale P.
TI Breast Cancer Risk Perception and Lifestyle Behaviors Among White and
Black Women With a Family History of the Disease
SO CANCER NURSING
LA English
DT Article
DE Breast cancer; Family history; Lifestyle behaviors; Risk perception
ID 1ST-DEGREE RELATIVES; QUALITATIVE RESEARCH; PREVENTION; PREDICTORS;
NUTRITION; TAMOXIFEN; AWARENESS; CHOICES
AB Although researchers have Investigated the relationships between perceived risk and behavioral risk factors for breast cancer, few qualitative studies have addressed the meaning of risk and its impact on decision making regarding lifestyle behaviors. This qualitative study explored factors involved in the formulation of perceived breast cancer risk and associations between risk perception and lifestyle behaviors in white and black women with a family history of breast cancer. Eligible participants were North Carolina residents in the Sister Study, a nationwide study of risk factors for breast cancer among women who have at least 1 sister diagnosed with breast cancer. Personal interviews were conducted with 32 women. Although most had heightened perceived risk, almost 20% considered themselves below-to-average risk. Participants with moderate-to-high perceived risk were more likely to report an affected sister and mother, a first-degree relative's diagnosis within 4 years, and death of a first-degree relative from breast cancer. Many women were unaware of associations between lifestyle behaviors and breast cancer risk. Only one-third of the women reported healthy lifestyle changes because of family history; dietary change was most frequently reported. Findings may be important for cancer nurses involved in developing breast cancer education programs for women with a family history of breast cancer.
C1 [Spector, Denise; Mishel, Merle; VanRiper, Marcia] Univ N Carolina, Sch Nursing, Chapel Hill, NC USA.
[Skinner, Celette Sugg] Univ Texas SW Med Ctr Dallas, Dept Clin Sci, Div Behav & Commun Sci, Dallas, TX 75390 USA.
[DeRoo, Lisa A.; Sandler, Dale P.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA.
RP Spector, D (reprint author), 318 Sunset Creek Circle, Chapel Hill, NC 27516 USA.
EM dspector@email.unc.edu
OI Sandler, Dale/0000-0002-6776-0018
FU National Institute of Nursing Research and the National Center on
Minority Health and Health Disparities [P20 NR 8369]; American Cancer
Society, Doctoral Degree Scholarship in Cancer Nursing [DSCN-07-132-01];
National Institute of Health, National Institute of Environmental Health
Sciences [Z01 ES044005-10]
FX The Center for Innovations in Health Disparities Research from the
National Institute of Nursing Research and the National Center on
Minority Health and Health Disparities provided the funds to conduct
this research under grant P20 NR 8369. The First author was supported by
the American Cancer Society through a Doctoral Degree Scholarship in
Cancer Nursing (grant no. DSCN-07-132-01). This research was also
supported in part by the Intramural Program of the National Institute of
Health, National Institute of Environmental Health Sciences (Z01
ES044005-10).
NR 43
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Z9 14
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0162-220X
J9 CANCER NURS
JI Cancer Nurs.
PD JUL-AUG
PY 2009
VL 32
IS 4
BP 299
EP 308
PG 10
WC Oncology; Nursing
SC Oncology; Nursing
GA 465MK
UT WOS:000267589300006
PM 19444084
ER
PT J
AU Tan, S
Meiller, J
Mahaffey, K
AF Tan, Shirlee
Meiller, Jesse
Mahaffey, Kathryn
TI Response to letter from Dr. Gianpaolo-Guzzi related to "The Endocrine
Effects of Mercury on Humans and Wildlife"
SO CRITICAL REVIEWS IN TOXICOLOGY
LA English
DT Letter
C1 [Tan, Shirlee; Meiller, Jesse; Mahaffey, Kathryn] US EPA, Off Sci Coordinat & Policy, Washington, DC 20460 USA.
RP Mahaffey, K (reprint author), US EPA, Off Sci Coordinat & Policy, Washington, DC 20460 USA.
EM tan.shirlee@epa.gov
NR 0
TC 0
Z9 0
U1 2
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1040-8444
J9 CRIT REV TOXICOL
JI Crit. Rev. Toxicol.
PD JUL
PY 2009
VL 39
IS 6
BP 539
EP 539
DI 10.1080/10408440903056971
PG 1
WC Toxicology
SC Toxicology
GA 478FA
UT WOS:000268572000007
ER
PT J
AU Brooks, JR
Coulombe, R
AF Brooks, J. Renee
Coulombe, Rob
TI Physiological responses to fertilization recorded in tree rings:
isotopic lessons from a long-term fertilization trial
SO ECOLOGICAL APPLICATIONS
LA English
DT Article
DE carbon isotope; Douglas-fir; growth; leaf area dynamics; nitrogen
additions; oxygen isotope; photosynthesis; Pseudotsuga menziesii; stable
isotopes; stomatal conductance; tree rings
ID DOUGLAS-FIR TREES; WATER-USE EFFICIENCY; NORTHWEST CONIFEROUS FORESTS;
LEAF WATER; STOMATAL CONDUCTANCE; PACIFIC-NORTHWEST; GROWTH-RESPONSE;
STABLE OXYGEN; LOBLOLLY-PINE; GAS-EXCHANGE
AB Nitrogen fertilizer applications are common land use management tools, but details on physiological responses to these applications are often lacking, particularly for long-term responses over decades of forest management. We used tree ring growth patterns and stable isotopes to understand long-term physiological responses to fertilization using a controlled fertilization experiment begun in 1964 in Washington State (USA), in which three levels of nitrogen fertilizer were applied: 157, 314, and 471 kg/ha. Basal area increment (BAI) increased more than fourfold in the highest treatment to twofold in the lowest, and a significant increase in BAI was observed for 20 years. Latewood Delta(13)C sharply decreased by 1.4% after fertilization and was significantly lower than controls for four years, but no differences existed between fertilization levels, and the effect disappeared after four years, indicating that intrinsic water use efficiency (A/gs) increased in response to fertilization. Earlywood D 13 C showed similar trends but was more variable. Latewood delta(18)O increased significantly above controls by similar to 2%omicron in all treatments, but the duration differed with treatment level, with the effect being longer for higher levels of fertilization and lasting as long as nine years after fertilization. Because source water and relative humidity were the same between experimental plots, we interpreted the delta(18)O increase with treatment as a decrease in leaf-level transpiration. Earlywood delta(18)O did not show any treatment effects. Because the Pacific Northwest has a mediterranean climate with dry summers, we speculated that fertilization caused a substantial increase in leaf area, causing the trees to transpire themselves into drought stress during the late summer. We estimate from the delta(18)O data that stomatal conductance (g(s)) was reduced by similar to 30%. Using the Delta(13)C data to estimate assimilation rates (A), A during the late season was also reduced by 20-30%. If leaf-level A decreased, but BAI increased, we estimated that leaf area on those trees must have increased by fourfold with the highest level of treatment within this stand. This increase in leaf area resulting from fertilization caused a hydraulic imbalance within the trees that lasted as long as nine years after treatment at the highest levels of fertilization.
C1 [Brooks, J. Renee] US EPA, NHEERL, Western Ecol Div, Corvallis, OR 97333 USA.
[Coulombe, Rob] Dynamac Corp, Corvallis, OR 97333 USA.
RP Brooks, JR (reprint author), US EPA, NHEERL, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA.
EM Brooks.ReneeJ@epa.gov
OI Brooks, Renee/0000-0002-5008-9774
FU U. S. Environmental Protection Agency
FX This work was supported by the U. S. Environmental Protection Agency.
This manuscript has been subjected to the Environmental Protection
Agency's peer and administrative review, and it has been approved for
publication as an EPA document. Mention of trade names or commercial
products does not constitute endorsement or recommendation for use. This
research was conducted at the Wind River Experimental Forest. We thank
the USDA Forest Service, Pacific Northwest Research Station, and the
Gifford Pinchot National Forest for making these facilities available
and for maintaining long-term measurements of forest and environmental
conditions. In this regard, special thanks go to Connie Harrington and
Sarah Greene for their assistance with access and historical data at
this site. We also thank Gail Heine for help with sample collection,
Warren Evans for sample processing, and William Rugh and William Griffis
for isotopic analysis. Special thanks to Margaret Barbour, E. Henry Lee,
and Donald Phillips, who helped with aspects of the data analysis.
Thanks to the EPA Isotopics journal group, Margaret Barbour, Tom
Hinckley, and Bob Ozretich, who provided comments on earlier versions of
this paper.
NR 79
TC 32
Z9 32
U1 1
U2 26
PU ECOLOGICAL SOC AMER
PI WASHINGTON
PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA
SN 1051-0761
J9 ECOL APPL
JI Ecol. Appl.
PD JUL
PY 2009
VL 19
IS 4
BP 1044
EP 1060
DI 10.1890/08-0310.1
PG 17
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 448SD
UT WOS:000266281400017
PM 19544742
ER
PT J
AU Greene, RM
Lehrter, JC
Hagy, JD
AF Greene, Richard M.
Lehrter, John C.
Hagy, James D., III
TI Multiple regression models for hindcasting and forecasting midsummer
hypoxia in the Gulf of Mexico
SO ECOLOGICAL APPLICATIONS
LA English
DT Article
DE forecasts; Gulf of Mexico; hindcasts; hypoxia; Mississippi River; Monte
Carlo; nitrogen; phosphorus, regression models
ID STOICHIOMETRIC NUTRIENT BALANCE; MISSISSIPPI RIVER-BASIN; COASTAL
EUTROPHICATION; LOUISIANA SHELF; WATER-QUALITY; NITROGEN; VARIABILITY;
SEDIMENTS; PIGMENTS; HISTORY
AB A new suite of multiple regression models was developed that describes relationships between the area of bottom water hypoxia along the northern Gulf of Mexico and Mississippi-Atchafalaya River nitrate concentration, total phosphorus (TP) concentration, and discharge. Model input variables were derived from two load estimation methods, the adjusted maximum likelihood estimation (AMLE) and the composite (COMP) method, developed by the U. S. Geological Survey. Variability in midsummer hypoxic area was described by models that incorporated May discharge, May nitrate, and February TP concentrations or their spring (discharge and nitrate) and winter (TP) averages. The regression models predicted the observed hypoxic area within +/-30%, yet model residuals showed an increasing trend with time. An additional model variable, Epoch, which allowed post-1993 observations to have a different intercept than earlier observations, suggested that hypoxic area has been 6450 km(2) greater per unit discharge and nutrients since 1993. Model forecasts predicted that a dual 45% reduction in nitrate and TP concentration would likely reduce hypoxic area to approximately 5000 km(2), the coastal goal established by the Mississippi River/Gulf of Mexico Watershed Nutrient Task Force. However, the COMP load estimation method, which is more accurate than the AMLE method, resulted in a smaller predicted hypoxia response to any given nutrient reduction than models based on the AMLE method. Monte Carlo simulations predicted that five years after an instantaneous 50% nitrate reduction or dual 45% nitrate and TP reduction it would be possible to resolve a significant reduction in hypoxic area. However, if nutrient reduction targets were achieved gradually (e. g., over 10 years), much more than a decade would be required before a significant downward trend in both nutrient concentrations and hypoxic area could be resolved against the large background of interannual variability. The multiple regression models and statistical approaches applied provide improved capabilities for evaluating dual nutrient management strategies to address Gulf hypoxia and a clearer perspective on the strengths and limitations of approaching the problem using regression models.
C1 [Greene, Richard M.; Lehrter, John C.; Hagy, James D., III] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP Greene, RM (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM greene.rick@epa.gov
RI Greene, Richard/G-9685-2013
FU U.S. Environmental Protection Agency
FX The authors appreciate the advice and assistance of Brent Aulenbach
(USGS) on the load estimation methodologies. We thank Craig Stow (NOAA),
Michael Murrell (USEPA), and two anonymous reviewers for valuable
comments on the manuscript. The information in this document has been
funded wholly (or in part) by the U.S. Environmental Protection Agency.
It has been subjected to review by the National Health and Environmental
Effects Research Laboratory and approved for publication. Approval does
not signify that the contents reflect the views of the Agency, nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use. This is contribution number #1323 from the Gulf
Ecology Division.
NR 45
TC 49
Z9 49
U1 0
U2 15
PU ECOLOGICAL SOC AMER
PI WASHINGTON
PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA
SN 1051-0761
J9 ECOL APPL
JI Ecol. Appl.
PD JUL
PY 2009
VL 19
IS 5
BP 1161
EP 1175
DI 10.1890/08-0035.1
PG 15
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 458KW
UT WOS:000267020200008
PM 19688924
ER
PT J
AU Fritz, KM
Glime, JM
Hribljan, J
Greenwood, JL
AF Fritz, Ken M.
Glime, Janice M.
Hribljan, John
Greenwood, Jennifer L.
TI Can bryophytes be used to characterize hydrologic permanence in forested
headwater streams?
SO ECOLOGICAL INDICATORS
LA English
DT Article
DE Jurisdictional waters; Mosses; Liverworts; Intermittent; Ephemeral;
Perennial
ID SUBSTRATE STABILITY; AQUATIC MUSCI; DISTURBANCE; HABITAT; ADAPTATIONS;
ASSEMBLAGES; COMMUNITY; MOUNTAINS; MOSSES
AB Recent court cases have questioned whether all headwater streams, particularly those that are not perennial, fall within the protective boundaries of the Clean Water Act. Rapid field-based indicators of hydrologic permanence are critically needed for jurisdictional determinations. The study objective was to determine whether characteristics of bryophyte assemblages in forested headwater streams can be useful indicators of hydrologic permanence. We sampled bryophytes from the channel thalweg at 113 sites across 10 forests in the U.S. which varied in hydrologic permanence. Hydrologic permanence was based on hydrologic status during spring (wet season) and late summer (dry season) visits. Perennial sites had flow (surface or visibly interstitial) during both spring and summer visits. Intermittent sites flowed during spring but were either dry or had surface water limited to isolated pools in summer. Ephemeral sites did not have flow during either visit. The species composition significantly differed between ephemeral and perennial stream reaches. The species composition of intermittent streams overlapped with both ephemeral and perennial streams. Three species and six families were identified as indicators of particular permanence classes. Liverworts occurred more frequently at perennial than at intermittent or ephemeral sites. Bryophytes with cushion and turf growth forms were common to ephemeral sites, whereas mat and weft forms were more common to perennial sites. Acrocarpous mosses were more frequent at ephemeral than at perennial sites. The frequencies of bryophyte-moisture associations (derived from the literature) across the three permanence categories were significantly different. Species associated with dry habitats were more frequently encountered at ephemeral than perennial sites, whereas species associated with wet habitats were more frequent at perennial than ephemeral sites. Species richness varied among forests and permanence classes. Ephemeral sites tended to have higher species richness than perennial sites; however, this pattern did not hold for all forests. Bryophytes should be included among the tools for jurisdictional determinations, much like vascular plants are used to help delineate wetlands. Growth forms and higher level taxonomy of bryophytes (i.e., phyla) can be particularly useful for making jurisdictional determinations because of their ability to discriminate ephemeral from intermittent and perennial reaches and they are measures that can be rapidly trained and routinely used by agencies making such determinations. Published by Elsevier Ltd.
C1 [Fritz, Ken M.] US EPA, Natl Exposure Res Div, Cincinnati, OH 45268 USA.
[Glime, Janice M.; Hribljan, John] Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA.
[Greenwood, Jennifer L.] Univ Tennessee, Dept Biol Sci, Martin, TN 38238 USA.
RP Fritz, KM (reprint author), US EPA, Natl Exposure Res Div, Cincinnati, OH 45268 USA.
EM fritz.ken@epa.gov
RI Fritz, Ken/A-9868-2013
NR 84
TC 19
Z9 19
U1 2
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1470-160X
J9 ECOL INDIC
JI Ecol. Indic.
PD JUL
PY 2009
VL 9
IS 4
BP 681
EP 692
DI 10.1016/j.ecolind.2008.09.001
PG 12
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 407WR
UT WOS:000263395500007
ER
PT J
AU Angradi, TR
Pearson, MS
Jicha, TM
Taylor, DL
Bolgrien, DW
Moffett, MF
Blocksom, KA
Hill, BH
AF Angradi, Ted R.
Pearson, Mark S.
Jicha, Terri M.
Taylor, Debra L.
Bolgrien, David W.
Moffett, Mary F.
Blocksom, Karen A.
Hill, Brian H.
TI Using stressor gradients to determine reference expectations for great
river fish assemblages
SO ECOLOGICAL INDICATORS
LA English
DT Article
DE Bioassessment; Great rivers; Reference condition; Stressor gradient;
Upper Mississippi River; Missouri River; Ohio River; Fish
ID MULTIMETRIC INDEX; BIOLOGICAL CONDITION; BIOTIC INTEGRITY;
UNITED-STATES; OHIO RIVER; STREAMS; WATER; ECOSYSTEMS
AB We describe a simple empirical modeling approach for determining least-disturbed conditions for the great rivers of the Upper Mississippi River basin: Missouri, Upper Mississippi, and Ohio Rivers. We used multivariate analysis to identify reference strata (reaches for which a single reference expectation was appropriate) on each river. Strata included the Upper Missouri, Lower Missouri, impounded Upper Mississippi, unimpounded Upper Mississippi, and the Ohio River. We created a multimetric stressor gradient for each stratum using a suite of site- and landscape-scale metrics. Site-scale metrics included water chemistry, aquatic and riparian habitat, and human disturbance metrics. Landscape-scale metrics included land use, land cover, and proximity to human disturbance. The gradient was scaled from 0 (least stressed) to 1 (most stressed). Multimetric indices of condition based on fish assemblages for the Lower Missouri and Upper Mississippi River were responsive to stressor gradients based on 18-24 abiotic stressor metrics. Ohio River fish assemblages were responsive to a hand-picked three-metric gradient. We used the y-intercept of quantile regression to predict the fish index value for a stressor gradient value of 0 (the fish index value at a site with the lowest mean stressor gradient score in the reference stratum) which we designated as least-disturbed condition for the fish index for that stratum. We trisected the difference between predicted least-disturbed condition (ceiling value) and a floor value set at the 5th percentile of the sample to create thresholds for three condition classes: least-disturbed, intermediate, and most-disturbed. Based on the derived condition class thresholds for the fish index, 10% (by length) of the Lower Missouri was in least-disturbed condition, compared to 14% of the Ohio River and 19% of the impounded Upper Mississippi River. The index of condition exhibited longitudinal variation that was associated with the location of major urban areas along each river. We conclude that empirical modeling based on an abiotic stressor gradient can provide an alternative approach for deriving internal reference expectations for great rivers with few, if any, minimally disturbed sites. Published by Elsevier Ltd.
C1 [Angradi, Ted R.; Pearson, Mark S.; Jicha, Terri M.; Taylor, Debra L.; Bolgrien, David W.; Moffett, Mary F.; Hill, Brian H.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[Blocksom, Karen A.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Angradi, TR (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, 1201 Congdon Blvd, Duluth, MN 55804 USA.
EM Angradi.theodore@epa.gov
RI Hill, Brian/E-6799-2013
NR 41
TC 30
Z9 34
U1 0
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1470-160X
J9 ECOL INDIC
JI Ecol. Indic.
PD JUL
PY 2009
VL 9
IS 4
BP 748
EP 764
DI 10.1016/j.ecolind.2008.09.007
PG 17
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 407WR
UT WOS:000263395500014
ER
PT J
AU Franceschini, MD
Lane, OP
Evers, DC
Reed, JM
Hoskins, B
Romero, LM
AF Franceschini, Melinda D.
Lane, Oksana P.
Evers, David C.
Reed, J. Michael
Hoskins, Bart
Romero, L. Michael
TI The corticosterone stress response and mercury contamination in
free-living tree swallows, Tachycineta bicolor
SO ECOTOXICOLOGY
LA English
DT Article
DE Corticosterone; Mercury; Stress; Tree swallows
ID NORTHEASTERN NORTH-AMERICA; PITUITARY-INTERRENAL AXIS; PAPER-MILL
EFFLUENT; ST-LAWRENCE-RIVER; COMMON LOONS; CHLORINATED HYDROCARBONS;
ADRENOCORTICAL-RESPONSE; SELENIUM CONCENTRATIONS; REPRODUCTIVE SUCCESS;
BUFO-TERRESTRIS
AB We determined mercury concentrations in tree swallows, Tachycineta bicolor, from Massachusetts and Maine with different levels of contamination. Baseline and stress-induced plasma corticosterone concentrations from adults and nestlings (Massachusetts only) were compared with mercury concentrations. In Massachusetts, adult baseline corticosterone was negatively correlated with blood mercury, but showed a nearly-significant positive correlation with feather mercury. There was a negative relationship between baseline corticosterone and blood mercury in nestlings and between baseline corticosterone and egg mercury. There was no relationship between mercury and stress-induced corticosterone in any of the groups, or with baseline corticosterone in Maine sites where mercury levels were lower. The findings suggest blood and egg mercury may be a better indicator of current condition than feather mercury. Further, mercury contamination may not alter stress-induced corticosterone concentrations in tree swallows but appears to have a significant impact on baseline circulating corticosterone.
C1 [Franceschini, Melinda D.; Reed, J. Michael; Romero, L. Michael] Tufts Univ, Dept Biol, Medford, MA 02155 USA.
[Lane, Oksana P.; Evers, David C.] BioDivers Res Inst, Gorham, ME 04038 USA.
[Hoskins, Bart] US EPA, New England Reg Lab, N Chelmsford, MA 01863 USA.
RP Franceschini, MD (reprint author), Tufts Univ, Dept Biol, Medford, MA 02155 USA.
EM melfrances@earthlink.net
RI Piper, Walter/B-7908-2009
FU Tufts University Institute for the Environment; US National Science
Foundation [IBN-0235044, IOB-0542099]
FX This project was made possible through a grant from Tufts University
Institute for the Environment to MDF, and grants from the US National
Science Foundation (IBN-0235044 and IOB-0542099) to LMR.
NR 61
TC 28
Z9 28
U1 3
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0963-9292
J9 ECOTOXICOLOGY
JI Ecotoxicology
PD JUL
PY 2009
VL 18
IS 5
BP 514
EP 521
DI 10.1007/s10646-009-0309-2
PG 8
WC Ecology; Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 454BC
UT WOS:000266655600005
PM 19360470
ER
PT J
AU Miller, MD
Crofton, KM
Rice, DC
Zoeller, RT
AF Miller, Mark D.
Crofton, Kevin M.
Rice, Deborah C.
Zoeller, R. Thomas
TI Thyroid-Disrupting Chemicals: Interpreting Upstream Biomarkers of
Adverse Outcomes
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
DE children's health; endocrine disruption; hazard identification; risk
assessment; science policy; thyroid hormone; toxicologic assessments
ID POLYCHLORINATED BIPHENYL PCB; NUTRITION EXAMINATION SURVEY; CEREBELLAR
GRANULE CELLS; SODIUM-IODIDE SYMPORTER; DIOXIN-LIKE COMPOUNDS; MATERNAL
HYPOTHYROXINEMIA; HORMONE RECEPTOR; RISK-ASSESSMENT; SUBCLINICAL
HYPOTHYROIDISM; CONGENITAL HYPOTHYROIDISM
AB BACKGROUND: There is increasing evidence in humans and in experimental animals for a relationship between exposure to specific environmental chemicals and perturbations in levels of critically important thyroid hormones (THs). Identification and proper interpretation of these relationships are required for accurate assessment of risk to public health.
OBJECTIVES: We review the role of TH in nervous system development and specific outcomes in adults, the impact of xenobiotics on thyroid signaling, the relationship between adverse outcomes of thyroid disruption and upstream causal biomarkers, and the societal implications of perturbations in thyroid signaling by xenobiotic chemicals.
DATA SOURCES: We drew on an extensive body of epidemiologic, toxicologic, and mechanistic studies.
DATA SYNTHESIS: THs are critical for normal nervous system development, and decreased maternal TH levels are associated with adverse neuropsychological development in children. In adult humans, increased thyroid-stimulating hormone is associated with increased blood pressure and poorer blood lipid profiles, both risk factors for cardiovascular disease and death. These effects of thyroid suppression are observed even within the "normal" range for the population. Environmental chemicals may affect thyroid homeostasis by a number of mechanisms, and multiple chemicals have been identified that interfere with thyroid function by each of the identified mechanisms.
CONCLUSIONS: Individuals are potentially vulnerable to adverse effects as a consequence of exposure to thyroid-disrupting chemicals. Any degree of thyroid disruption that affects TH levels on a population basis should be considered a biomarker of adverse outcomes, which may have important societal outcomes.
C1 [Miller, Mark D.] Calif Environm Protect Agcy, Off Environm Hlth Hazard Assessment, Oakland, CA 94612 USA.
[Miller, Mark D.] Univ Calif San Francisco, Pediat Environm Hlth Specialty Unit, San Francisco, CA 94143 USA.
[Crofton, Kevin M.] US EPA, Natl Hlth & Environm Effects Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Rice, Deborah C.] Maine Ctr Dis Control, Augusta, ME USA.
[Zoeller, R. Thomas] Univ Massachusetts, Dept Biol, Morrill Sci Ctr, Amherst, MA 01003 USA.
RP Miller, MD (reprint author), Calif Environm Protect Agcy, Off Environm Hlth Hazard Assessment, 1515 Clay St,16th Floor, Oakland, CA 94612 USA.
EM mmiller@oehha.ca.gov
RI Crofton, Kevin/J-4798-2015;
OI Crofton, Kevin/0000-0003-1749-9971; Miller, Mark/0000-0002-9301-0093
NR 144
TC 93
Z9 98
U1 2
U2 29
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JUL
PY 2009
VL 117
IS 7
BP 1033
EP 1041
DI 10.1289/ehp.0800247
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 465WV
UT WOS:000267621200019
PM 19654909
ER
PT J
AU Graff, DW
Cascio, WE
Rappold, A
Zhou, HB
Huang, YCT
Devlin, RB
AF Graff, Donald W.
Cascio, Wayne E.
Rappold, Ana
Zhou, Haibo
Huang, Yuh-Chin T.
Devlin, Robert B.
TI Exposure to Concentrated Coarse Air Pollution Particles Causes Mild
Cardiopulmonary Effects in Healthy Young Adults
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE cardiovascular effects; coarse PM human study
ID HEART-RATE-VARIABILITY; ACUTE ARTERIAL VASOCONSTRICTION; CARDIAC
OXIDATIVE STRESS; PARTICULATE MATTER; FINE PARTICLES; DAILY MORTALITY;
ULTRAFINE PARTICLES; ASTHMATIC VOLUNTEERS; PLASMA-FIBRINOGEN; INHALED
PARTICLES
AB BACKGROUND: There is ample epidemiologic and toxicologic evidence that exposure to fine particulate matter (PM) air pollution [aerodynamic diameter <= 2.5 mu m (PM(2.5))], which derives primarily from combustion processes, can result in increased mortality and morbidity. There is less certainty as to the contribution of coarse PM (PM(2.5-10)), which derives from crustal materials and from mechanical processes, to mortality and morbidity.
OBJECTIVE: To determine whether coarse PM causes cardiopulmonary effects, we exposed 14 healthy young volunteers to coarse concentrated ambient particles (CAPs) and filtered air. Coarse PM concentration averaged 89.0 mu g/m(3) (range, 23.7-159.6 mu g/m(3)). Volunteers were exposed to coarse CAPs and filtered air for 2 hr while they underwent intermittent exercise in a single-blind, crossover study. We measured pulmonary, cardiac, and hematologic end points before exposure, immediately after exposure, and again 20 hr after exposure.
RESULTS: Compared with filtered air exposure, coarse CAP exposure produced a small increase in polymorphonuclear neutrophils in the bronchoalveolar lavage fluid 20 hr postexposure, indicating mild pulmonary inflammation. We observed no changes in pulmonary function. Blood tissue plasminogen activator, which is involved in fibrinolysis, was decreased 20 hr after exposure. The standard deviation of normal-to-normal intervals (SDNN), a measure of overall heart rate variability, also decreased 20 hr after exposure to CAPs.
CONCLUSIONS: Coarse CAP exposure produces a mild physiologic response in healthy young volunteers approximately 20 hr postexposure. These changes are similar in scope and magnitude to changes we and others have previously reported for volunteers exposed to fine CAPs, suggesting that both size fractions are comparable at inducing cardiopulmonary changes in acute exposure settings.
C1 [Rappold, Ana; Devlin, Robert B.] US EPA, NHEERL, Human Studies Div, Res Triangle Pk, NC 27711 USA.
[Graff, Donald W.] MDS Pharma Serv, Lincoln, NE USA.
[Cascio, Wayne E.] E Carolina Univ, Brody Sch Med, Dept Cardiovasc Sci, Greenville, NC USA.
[Zhou, Haibo] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA.
[Huang, Yuh-Chin T.] Duke Univ, Sch Med, Durham, NC USA.
RP Devlin, RB (reprint author), US EPA, NHEERL, Human Studies Div, MD 58D, Res Triangle Pk, NC 27711 USA.
EM Devlin.robert@epa.gov
NR 49
TC 61
Z9 62
U1 1
U2 19
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JUL
PY 2009
VL 117
IS 7
BP 1089
EP 1094
DI 10.1289/ehp0900558
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 465WV
UT WOS:000267621200028
PM 19654918
ER
PT J
AU Liebow, E
Phelps, J
Van Houten, B
Rose, S
Orians, C
Cohen, J
Monroe, P
Drew, CH
AF Liebow, Edward
Phelps, Jerry
Van Houten, Bennett
Rose, Shyanika
Orians, Carlyn
Cohen, Jennifer
Monroe, Philip
Drew, Christina H.
TI Toward the Assessment of Scientific and Public Health Impacts of the
National Institute of Environmental Health Sciences Extramural Asthma
Research Program Using Available Data
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE asthma; children; evaluation methodology; health impact analysis;
minorities; policy; pulmonary organ systems/disease processes;
susceptible populations
ID COMMUNITY; CHILDREN; CARE
AB BACKGROUND: In the past 15 years, asthma prevalence has increased and is disproportionately distributed among children, minorities, and low-income persons. The National Institute of Environmental Health Sciences (NIEHS) Division of Extramural Research and Training developed a framework to measure the scientific and health impacts of its extramural asthma research to improve the scientific basis for reducing the health effects of asthma.
OBJECTIVES: Here we apply the framework to characterize the NIEHS asthma portfolio's impact in terms of publications, clinical applications of findings, community interventions, and technology developments.
METHODS: A logic model was tailored to inputs, outputs, and outcomes of the NIEHS asthma portfolio. Data from existing National Institutes of Health (NIH) databases are used, along with publicly available bibliometric data and structured elicitation of expert judgment.
RESULTS: NIEHS is the third largest source of asthma-related research grant funding within the NIH between 1975 and 2005, after the National Heart, Lung, and Blood Institute and the National Institute of Allergy and Infectious Diseases. Much of NIEHS-funded asthma research focuses on basic research, but results are often published in journals focused on clinical investigation, increasing the likelihood that the work is moved into practice along the "bench to bedside" continuum. NIEHS support has led to key breakthroughs in scientific research concerning susceptibility to asthma, environmental conditions that heighten asthma symptoms, and cellular mechanisms that may be involved in treating asthma.
CONCLUSIONS: If gaps and limitations in publicly available data receive adequate attention, further linkages can be demonstrated between research activities and public health improvements. This logic model approach to research impact assessment demonstrates that it is possible to conceptualize program components, mine existing databases, and begin to show longer-term impacts of program results. The next challenges will be to modify current data structures, improve the linkages among relevant databases, incorporate as much electronically available data as possible, and determine how to improve the quality and health impact of the science that we support.
C1 [Liebow, Edward; Rose, Shyanika; Orians, Carlyn; Cohen, Jennifer; Monroe, Philip] Battelle Hlth & Life Sci, Seattle, WA 98109 USA.
[Phelps, Jerry; Drew, Christina H.] Natl Inst Environm Hlth Sci, Div Extramural Res & Training, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
[Van Houten, Bennett] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA.
RP Liebow, E (reprint author), Battelle Hlth & Life Sci, 1100 Dexter Ave N,Suite 400, Seattle, WA 98109 USA.
EM liebowe@battelle.org
OI Liebow, Edward/0000-0002-1101-629X
FU National Institute of Environmental Health Sciences (NIEHS)
[HHSP23320045006XI/T.O, HHSP233000015T]
FX This work was completed with support from National Institute of
Environmental Health Sciences (NIEHS) contract HHSP23320045006XI/T.O
HHSP233000015T.
NR 22
TC 7
Z9 7
U1 1
U2 11
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JUL
PY 2009
VL 117
IS 7
BP 1147
EP 1154
DI 10.1289/ehp.0800476
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 465WV
UT WOS:000267621200036
PM 19654926
ER
PT J
AU Kramer, MG
Firestone, M
Kavlock, R
Zenick, H
AF Kramer, Melissa G.
Firestone, Michael
Kavlock, Robert
Zenick, Harold
TI The Future of Toxicity Testing for Environmental Contaminants
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Editorial Material
C1 [Firestone, Michael] US EPA, Off Childrens Hlth Protect & Environm Educ, Washington, DC 20460 USA.
[Kavlock, Robert; Zenick, Harold] US EPA, Off Res & Dev, Washington, DC 20460 USA.
[Kramer, Melissa G.] US EPA, Off Sci Advisor, Washington, DC 20460 USA.
EM Kramer.melissa@epa.gov
NR 10
TC 2
Z9 2
U1 1
U2 2
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JUL
PY 2009
VL 117
IS 7
BP A283
EP A284
DI 10.1289/ehp.12891
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 465WV
UT WOS:000267621200002
PM 19654891
ER
PT J
AU Smith, LM
Macauley, JM
Harwell, LC
Chancy, CA
AF Smith, Lisa M.
Macauley, John M.
Harwell, Linda C.
Chancy, Cynthia A.
TI Water Quality in the Near Coastal Waters of the Gulf of Mexico Affected
by Hurricane Katrina: Before and After the Storm
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Alabama; Assessment; Coastal waters; Estuaries; Gulf of Mexico;
Hurricane Katrina; Louisiana; Mississippi; Probabilistic survey; Water
quality
ID CLOSTRIDIUM-PERFRINGENS; MULTIPLE HURRICANES; PAMLICO SOUND; IMPACTS;
RIVER; BAY; ECOSYSTEMS; ESTUARIES; RECOVERY; ATLANTIC
AB Water quality was assessed following Hurricane Katrina in the affected waters of Alabama, Mississippi, and Louisiana. Post-landfall water quality was compared to pre-hurricane conditions using indicators assessed by EPA's National Coastal Assessment program and additional indicators of contaminants in water and pathogens. Water quality data collected after Hurricane Katrina suggest that the coastal waters affected by the storm exhibited higher salinity and concentrations of chlorophyll a, dissolved inorganic phosphorus, and total suspended solids following the storm compared to the previous 5-year averages. Higher bottom dissolved oxygen concentrations and light attenuation were also observed. Contaminant concentrations measured in the water column were very low or undetectable, as were the presence of pathogens. Overall water quality did not significantly differ from water quality assessed in the five years preceding the storm. Statistical analyses indicate that use of a probabilistic survey design is appropriate for making pre-storm and post storm comparisons for water quality condition on an areal basis.
C1 [Smith, Lisa M.; Macauley, John M.; Harwell, Linda C.; Chancy, Cynthia A.] US EPA, Gulf Ecol Div, Natl Hlth & Environm Effects Lab, Off Res & Dev, Gulf Breeze, FL 32561 USA.
RP Smith, LM (reprint author), US EPA, Gulf Ecol Div, Natl Hlth & Environm Effects Lab, Off Res & Dev, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM smith.lisam@epa.gov; macauley.john@epa.gov; harwell.linda@epa.gov;
chancy.cynthia@epa.gov
NR 48
TC 2
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U1 1
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
J9 ENVIRON MANAGE
JI Environ. Manage.
PD JUL
PY 2009
VL 44
IS 1
BP 149
EP 162
DI 10.1007/s00267-009-9300-1
PG 14
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 462GM
UT WOS:000267339100013
PM 19484287
ER
PT J
AU Mahmoud, M
Liu, YQ
Hartmann, H
Stewart, S
Wagener, T
Semmens, D
Stewart, R
Gupta, H
Dominguez, D
Dominguez, F
Hulse, D
Letcher, R
Rashleigh, B
Smith, C
Street, R
Ticehurst, J
Twery, M
van Delden, H
Waldick, R
White, D
Winter, L
AF Mahmoud, Mohammed
Liu, Yuqiong
Hartmann, Holly
Stewart, Steven
Wagener, Thorsten
Semmens, Darius
Stewart, Robert
Gupta, Hoshin
Dominguez, Damian
Dominguez, Francina
Hulse, David
Letcher, Rebecca
Rashleigh, Brenda
Smith, Court
Street, Roger
Ticehurst, Jenifer
Twery, Mark
van Delden, Hedwig
Waldick, Ruth
White, Denis
Winter, Larry
TI A formal framework for scenario development in support of environmental
decision-making
SO ENVIRONMENTAL MODELLING & SOFTWARE
LA English
DT Article
DE Alternative futures; Decision-making; Scenario analysis; Scenarios;
Scenario planning; Uncertainty
ID WATER-RESOURCES MANAGEMENT; RIVER-BASIN; UNCERTAINTY; FUTURE; MODEL;
LAND; TOOL; METHODOLOGY; ASIA
AB Scenarios are possible future states of the world that represent alternative plausible conditions under different assumptions. Often, scenarios are developed in a context relevant to stakeholders involved in their applications since the evaluation of scenario outcomes and implications can enhance decision-making activities. This paper reviews the state-of-the-art of scenario development and proposes a formal approach to scenario development in environmental decision-making. The discussion of current issues in scenario studies includes advantages and obstacles in utilizing a formal scenario development framework, and the different forms of uncertainty inherent in scenario development, as well as how they should be treated. An appendix for common scenario terminology has been attached for clarity. Major recommendations for future research in this area include proper consideration of uncertainty in scenario studies in particular in relation to stakeholder relevant information, construction of scenarios that are more diverse in nature, and sharing of information and resources among the scenario development research community. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Mahmoud, Mohammed; Stewart, Steven; Gupta, Hoshin; Dominguez, Francina] Univ Arizona, Dept Hydrol & Water Resources, Tucson, AZ 85721 USA.
[Liu, Yuqiong] NOAA, Natl Weather Serv, Off Hydrol Dev, Silver Spring, MD 20910 USA.
[Hartmann, Holly] Univ Arizona, Arid Lands Informat Ctr, Tucson, AZ 85719 USA.
[Wagener, Thorsten] Penn State Univ, Dept Civil & Environm Engn, University Pk, PA 16802 USA.
[Semmens, Darius] USGS Rocky Mt Geog Sci Ctr, Lakewood, CO 80225 USA.
[Stewart, Robert] Univ Tennessee, Inst Environm Modeling, Knoxville, TN 37996 USA.
[Dominguez, Damian] Swiss Fed Inst Aquat Sci & Technol, CH-8600 Dubendorf, Switzerland.
[Dominguez, Damian] ETH, Inst Environm Engn, CH-8093 Zurich, Switzerland.
[Hulse, David] Univ Oregon, Dept Landscape Architecture 5234, Eugene, OR 97403 USA.
[Letcher, Rebecca] Australian Natl Univ, Canberra, ACT 0200, Australia.
[Rashleigh, Brenda] US EPA, Off Res & Dev, Natl Exposure Res Lab, Athens, GA 30605 USA.
[Smith, Court] Oregon State Univ, Dept Anthropol, Corvallis, OR 97331 USA.
[Street, Roger] UKCIP OUCE, Oxford OX1 3QY, England.
[Ticehurst, Jenifer] Australian Natl Univ, Integrated Catchment Assessment & Management Ctr, Fenner Sch Environm & Soc, Canberra, ACT 0200, Australia.
[Twery, Mark] USDA Forest Serv Sci Technol & Appl Results, No Res Stn Program, S Burlington, VT 05403 USA.
[van Delden, Hedwig] RIKS, NL-6200 AL Maastricht, Netherlands.
[Waldick, Ruth] Environm Canada, Ottawa, ON K1A 0H3, Canada.
[White, Denis] US EPA, Corvallis, OR 97333 USA.
[Winter, Larry] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
RP Mahmoud, M (reprint author), Univ Arizona, Dept Hydrol & Water Resources, 1133 E James Rogers Way, Tucson, AZ 85721 USA.
EM mahmoud@email.arizona.edu
RI Gupta, Hoshin/D-1642-2010; Ticehurst, Jenifer/B-7707-2011; Wagener,
Thorsten/C-2062-2008; Liu, Yuqiong/B-4318-2012; Dominguez,
Francina/D-4412-2012;
OI Gupta, Hoshin/0000-0001-9855-2839; Wagener,
Thorsten/0000-0003-3881-5849; Stewart, Robert/0000-0002-8186-7559
FU US National Science Foundation Science; Technology Center for
Sustainability of semi-Arid Hydrology and Riparian Areas (SAHRA)
[EAR-9876800]
FX Support for this research was provided by the US National Science
Foundation Science and Technology Center for Sustainability of semi-Arid
Hydrology and Riparian Areas (SAHRA) under Grant EAR-9876800. The
research described in this article has been subjected to the US
Environmental Protection Agency's peer and administrative review and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
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U2 59
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1364-8152
EI 1873-6726
J9 ENVIRON MODELL SOFTW
JI Environ. Modell. Softw.
PD JUL
PY 2009
VL 24
IS 7
BP 798
EP 808
DI 10.1016/j.envsoft.2008.11.010
PG 11
WC Computer Science, Interdisciplinary Applications; Engineering,
Environmental; Environmental Sciences
SC Computer Science; Engineering; Environmental Sciences & Ecology
GA 435KC
UT WOS:000265341800003
ER
PT J
AU Munn, MD
Waite, IR
Larsen, DP
Herlihy, AT
AF Munn, Mark D.
Waite, Ian R.
Larsen, David P.
Herlihy, Alan T.
TI The relative influence of geographic location and reach-scale habitat on
benthic invertebrate assemblages in six ecoregions
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Benthic invertebrates; Ecoregions; Habitat; Geographic location
ID MID-ATLANTIC HIGHLANDS; ROCKY-MOUNTAIN STREAMS; ENVIRONMENTAL GRADIENTS;
MACROINVERTEBRATE ASSEMBLAGES; LANDSCAPE CLASSIFICATIONS; RIVER-BASIN;
LAND-USE; USA; COMMUNITIES; MICRODISTRIBUTION
AB The objective of this study was to determine the relative influence of reach-specific habitat variables and geographic location on benthic invertebrate assemblages within six ecoregions across the Western USA. This study included 417 sites from six ecoregions. A total of 301 taxa were collected with the highest richness associated with ecoregions dominated by streams with coarse substrate (19-29 taxa per site). Lowest richness (seven to eight taxa per site) was associated with ecoregions dominated by fine-grain substrate. Principle component analysis (PCA) on reach-scale habitat separated the six ecoregions into those in high-gradient mountainous areas (Coast Range, Cascades, and Southern Rockies) and those in lower-gradient ecoregions (Central Great Plains and Central California Valley). Nonmetric multidimensional scaling (NMS) models performed best in ecoregions dominated by coarse-grain substrate and high taxa richness, along with coarse-grain substrates sites combined from multiple ecoregions regardless of location. In contrast, ecoregions or site combinations dominated by fine-grain substrate had poor model performance (high stress). Four NMS models showed that geographic location (i.e. latitude and longitude) was important for: (1) all ecoregions combined, (2) all sites dominated by coarse-grain sub strate combined, (3) Cascades Ecoregion, and (4) Columbia Ecoregion. Local factors (i.e. substrate or water temperature) seem to be overriding factors controlling invertebrate composition across the West, regardless of geographic location.
C1 [Munn, Mark D.] US Geol Survey, Tacoma, WA 98402 USA.
[Waite, Ian R.] US Geol Survey, Portland, OR 97216 USA.
[Larsen, David P.] US EPA, WED, NHEERL, Corvallis, OR 97333 USA.
[Herlihy, Alan T.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA.
RP Munn, MD (reprint author), US Geol Survey, 934 Broadway,Suite 300, Tacoma, WA 98402 USA.
EM mdmunn@usgs.gov
FU USEPA EMAP; NAWQA
FX The research used in this paper was funded in part by the USEPA EMAP
program and the USEPA star grant, along with the U. S. Geological Survey
NAWQA program. The authors thank the EMAP and NAWQA teams involved in
the collection of data within the six ecoregions. We also thank
PatrickMoran and Jason May for their colleague review, along with the
anonymous reviewers for their helpful comments on the manuscript.
NR 42
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U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD JUL
PY 2009
VL 154
IS 1-4
BP 1
EP 14
DI 10.1007/s10661-008-0372-9
PG 14
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 468MT
UT WOS:000267824400001
PM 18629444
ER
PT J
AU McKinney, RA
Charpentier, MA
Wigand, C
AF McKinney, Richard A.
Charpentier, Michael A.
Wigand, Cathleen
TI Assessing the wildlife habitat value of New England salt marshes: I.
Model and application
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Salt marsh; Wildlife habitat; Assessment; Biodiversity; Marsh
restoration; New England; Narragansett Bay
ID LANDSCAPE; DIVERSITY; MOVEMENTS; ESTUARY; AREA
AB We developed an assessment model to quantify the wildlife habitat value of New England salt marshes based on marsh characteristics and the presence of habitat types that influence habitat use by terrestrial wildlife. Applying the model to 12 salt marshes located in Narragansett Bay, RI resulted in assessment scores that ranged over a factor of 1.5 from lowest to highest. Pre-classifying the results based on marsh size and morphology helped to compare assessment scores between marshes, and demonstrated that even the lower ranking marshes had substantial habitat value. Stepwise multiple regression analysis of assessment scores and model components demonstrated that salt marsh morphology, the degree of anthropogenic modification, and salt marsh vegetative heterogeneity were significant variables and accounted for 91.3% of the variability in component scores. Our results suggest that targeting these components for restoration may lead to improved assessment scores for our study marshes. We also examined the use of lower resolution remote sensing data in the assessment in order to minimize the time and effort required to complete the model. Scores obtained using smaller-scale, lower resolution data were significantly lower than those obtained using larger-scale, higher resolution data (df = 11; t = 2.2; p < 0.001). The difference was significantly positively correlated with the portion of the assessment score that could be attributed to trees, pools, and pannes and marsh size (r (2) =0.50, F = 4.6, p = 0.04), and could indicate a bias against smaller, more heterogeneous marshes. We conclude that potential differences need to be weighed against the time benefit of using this type of data, bearing in mind the marsh size and the goals of the assessment. Overall, our assessment can provide information to aid in prioritizing marshes for protection and restoration, identify marshes that may harbor significant biodiversity, or help monitor changes in habitat value over time.
C1 [McKinney, Richard A.; Wigand, Cathleen] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Charpentier, Michael A.] Comp Sci Corp, Narragansett, RI 02882 USA.
RP McKinney, RA (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM mckinney.rick@epa.gov
FU US Environmental Protection Agency [AED-07-100]
FX We thank Dan Campbell, James Lake, and Suzanne Lussier for providing
helpful comments on the manuscript. Mention of trade names or commercial
products does not constitute endorsement or recommendation. Although the
research described in this article has been funded wholly by the US
Environmental Protection Agency, it has not been subjected to
agency-level review. Therefore, it does not necessarily reflect the
views of the agency. This is the Office of Research and Development,
National Health and Environmental Effects Research Laboratory, Atlantic
Ecology Division contribution number AED-07-100.
NR 28
TC 4
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U1 2
U2 16
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD JUL
PY 2009
VL 154
IS 1-4
BP 29
EP 40
DI 10.1007/s10661-008-0375-6
PG 12
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 468MT
UT WOS:000267824400004
PM 18592388
ER
PT J
AU McKinney, RA
Charpentier, MA
Wigand, C
AF McKinney, Richard A.
Charpentier, Michael A.
Wigand, Cathleen
TI Assessing the wildlife habitat value of New England salt marshes: II.
Model testing and validation
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Salt marsh; Wildlife habitat; Assessment; Biodiversity; New England;
Greenwich Bay; Ardeidae; Wading birds
ID HUMAN DISTURBANCE; SPECIES RICHNESS; BUFFER ZONES; RESOURCE USE;
WETLAND; HERONS; BIRDS; EGRETS; LANDSCAPE; REPTILES
AB We tested a previously described model to assess the wildlife habitat value of New England salt marshes by comparing modeled habitat values and scores with bird abundance and species richness at sixteen salt marshes in Narragansett Bay, Rhode Island USA. As a group, wildlife habitat value assessment scores for the marshes ranged from 307-509, or 31-67% of the maximum attainable score. We recorded 6 species of wading birds (Ardeidae; herons, egrets, and bitterns) at the sites during biweekly survey. Species richness (r (2)=0.24, F=4.53, p=0.05) and abundance (r (2)=0.26, F=5.00, p=0.04) of wading birds significantly increased with increasing assessment score. We optimized our assessment model for wading birds by using Akaike information criteria (AIC) to compare a series of models comprised of specific components and categories of our model that best reflect their habitat use. The model incorporating pre-classification, wading bird habitat categories, and natural land surrounding the sites was substantially supported by AIC analysis as the best model. The abundance of wading birds significantly increased with increasing assessment scores generated with the optimized model (r (2)=0.48, F=12.5, p=0.003), demonstrating that optimizing models can be helpful in improving the accuracy of the assessment for a given species or species assemblage. In addition to validating the assessment model, our results show that in spite of their urban setting our study marshes provide substantial wildlife habitat value. This suggests that even small wetlands in highly urbanized coastal settings can provide important wildlife habitat value if key habitat attributes (e.g., natural buffers, habitat heterogeneity) are present.
C1 [McKinney, Richard A.; Wigand, Cathleen] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Charpentier, Michael A.] Comp Sci Corp, Narragansett, RI 02882 USA.
RP McKinney, RA (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM mckinney.rick@epa.gov
FU U.S. Environmental Protection Agency
FX We thank Jim Lake, Dan Campbell, Steve Ryba, and Walter Berry for
providing helpful comments on the manuscript. Mention of trade names or
commercial products does not constitute endorsement or recommendation.
Although the research described in this article has been funded wholly
by the U.S. Environmental Protection Agency, it has not been subjected
to Agency-level review. Therefore, it does not necessarily reflect the
views of the Agency. This is the Office of Research and Development,
National Health and Environmental Effects Research Laboratory, Atlantic
Ecology Division contribution number AED-07-101.
NR 35
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U1 1
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD JUL
PY 2009
VL 154
IS 1-4
BP 361
EP 371
DI 10.1007/s10661-008-0403-6
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 468MT
UT WOS:000267824400031
PM 18597178
ER
PT J
AU Becker, DS
Sexton, JE
Jacobs, LA
Hogarty, B
Keeley, K
AF Becker, D. Scott
Sexton, Jane E.
Jacobs, Lucinda A.
Hogarty, Barry
Keeley, Karen
TI Biological responses to sediment remediation based on thin layer
placement near a former pulp mill in Ward Cove, AK (USA)
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Benthic macroinvertebrates; Organic enrichment; Sediment toxicity; Thin
layer placement
ID SOUTHERN-CALIFORNIA BIGHT; MAINLAND SHELF; MACROBENTHOS
AB In 2001, 28 acres of the bottom of Ward Cove, AK (USA) were remediated using thin layer placement, to enhance the natural recovery of contaminated sediments. The remediated areas were part of an 80-acre area of concern identified offshore from the site of a former sulfite pulp mill. The primary chemicals of concern were those commonly associated with organic enrichment near pulp mills: ammonia and 4-methylphenol. The primary remedial objectives were to reduce the toxicity of the contaminated sediments and to stimulate colonization of the remediated areas by benthic macroinvertebrates. In 2004, the initial monitoring event for the remediated areas was conducted, and included evaluations of physical/chemical sediment variables (i.e., total organic carbon, grain size distribution, ammonia, and 4-methylphenol), sediment toxicity (i.e., using the 10-day amphipod survival test with Eohaustorius estuarius), and in situ benthic macroinvertebrate communities. Results of the monitoring event showed that conditions in the remediated areas had improved considerably in the 3 years since thin layer placement had occurred. At most stations, concentrations of both ammonia and 4-methylphenol were very low, and amphipod survival was a parts per thousand yen90%. In addition, benthic macroinvertebrates appeared to be rapidly colonizing the remediated areas, based on evaluations of several community metrics (i.e., taxa richness, diversity, and dominance), as well as key indicator species of organic enrichment and associated transitional areas (i.e., primarily the polychaetes Capitella capitata and Nephtys cornuta, and the bivalve molluscs Axinopsida serricata and Parvilucina tenuisculpta). In general, colonization was consistent with the patterns identified for areas recovering from organic enrichment on the continental shelf of southern California and elsewhere. Based on these results, thin layer placement was considered successful in enhancing the natural recovery of the remediated sediments in Ward Cove.
C1 [Becker, D. Scott; Jacobs, Lucinda A.] Integral Consulting Inc, Mercer Isl, WA 98040 USA.
[Becker, D. Scott; Sexton, Jane E.] Exponent Inc, Bellevue, WA 98007 USA.
[Hogarty, Barry] TECS AK, Ketchikan, AK 99901 USA.
[Keeley, Karen] US EPA, Seattle, WA 98101 USA.
RP Becker, DS (reprint author), Integral Consulting Inc, 7900 SE 28th St, Mercer Isl, WA 98040 USA.
EM sbecker@integral-corp.com
NR 29
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U1 1
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD JUL
PY 2009
VL 154
IS 1-4
BP 427
EP 438
DI 10.1007/s10661-008-0409-0
PG 12
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 468MT
UT WOS:000267824400037
PM 18677548
ER
PT J
AU White, EM
Keeler, GJ
Landis, MS
AF White, Emily M.
Keeler, Gerald J.
Landis, Matthew S.
TI Spatial Variability of Mercury Wet Deposition in Eastern Ohio:
Summertime Meteorological Case Study Analysis of Local Source Influences
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ATMOSPHERIC MERCURY; LAKE MICHIGAN; METHYLMERCURY; FISH
AB Extensive exploration of event precipitation data in the Ohio River Valley indicates that coal combustion emissions play an important role in mercury (Hg) wet deposition. During July-September 2006, an intensive study was undertaken to discern the degree of local source influence. Source-receptor relationships were explored by establishing a set of wet deposition sites in and around Steubenville, Ohio. For the three month period of study, volume-weighted mean Hg concentrations observed at the eight sites ranged from 10.2 to 22.3 ng L(-1), but this range increased drastically on an event basis with a maximum concentration of 89.4 ng L(-1) and a minimum concentration of 4.1 ng L(-1). subset of events was explored in depth, and the degree of variability in Hg concentrations between sites was linked to the degree of local source enhancement Samples collected at sites less than 1 km from coal-fired utility stacks (near-field) exhibited up to 72% enhancement in Hg concentrations over regionally representative samples on an event basis. Air mass transport and precipitating cell histories were traced in order to evaluate relationships between local point sources and receptor sites. It was found that the interaction of several dynamic atmospheric parameters combined to favor local Hg concentration enhancement over the more regional contribution. When significant meteorological factors (wind speed at time of maximum rain rate, wind speed 24 h prior to precipitation, mixing height and observed,ceiling) were explored, it was estimated that during summertime precipitation, 42% of Hg concentration in near-field samples could be attributed to the adjacent coal-fired utility source.
C1 [White, Emily M.; Keeler, Gerald J.] Univ Michigan, Air Qual Lab, Ann Arbor, MI 48109 USA.
[Landis, Matthew S.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Keeler, GJ (reprint author), Univ Michigan, Air Qual Lab, Ann Arbor, MI 48109 USA.
EM jkeeler@umich.edu
RI Landis, Matthew/P-5149-2014
OI Landis, Matthew/0000-0002-8742-496X
FU U.S. Environmental Protection Agency, Office of Research and Development
[R-82971601-0, EP07D000572]
FX This work has been funded wholly or in part by the U.S. Environmental
Protection Agency, Office of Research and Development, through
cooperative agreement R-82971601-0 and Student Services Contract
EP07D000572. It has been subjected to Agency review and approved for
publication. Mention of trade names or commercial products does not
constitute an endorsement or recommendation for use. We thank Jim Barres
and Ali Kamal of the University of Michigan Air Quality Laboratory
(UMAQL) for managing laboratory support operations; Dr. James Slater
(Franciscan University) for on-site logistical support; and Brie Van
Darn, David Reed, Naima Hall, and Lynne Gratz (UMAQL) for sample
preparation and collection support. Additional thanks to Daniel Walls of
Belmont County Sewer, Clarence Thompson and Tim Vittori of the Allegheny
County Parks Department, Todd Metz of the Ohio Department of Natural
Resource, and Todd Davis of Future Farmers of America (FFA) Camp
Muskingham.
NR 28
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U1 2
U2 13
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JUL 1
PY 2009
VL 43
IS 13
BP 4946
EP 4953
DI 10.1021/es803214h
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 463ME
UT WOS:000267435500052
PM 19673290
ER
PT J
AU Joo, SH
Al-Abed, SR
Luxton, T
AF Joo, Sung Hee
Al-Abed, Souhail R.
Luxton, Todd
TI Influence of Carboxymethyl Cellulose for the Transport of Titanium
Dioxide Nanoparticles in Clean Silica and Mineral-Coated Sands
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID NATURAL ORGANIC-MATTER; POROUS-MEDIA; IRON NANOPARTICLES;
IONIC-STRENGTH; ADSORPTION; AGGREGATION; DEPOSITION; SIZE;
STABILIZATION; WATER
AB The transport proper-des of titanium dioxide (anatase polymorph) nanoparticles encapsulated by carboxymethyl cellulose (CMC) were evaluated as a function of changes in the solute chemical properties in clean quartz, amorphous aluminum, and iron hydroxide-coated sands. While pristine anatase TiO(2) nanoparticles (ANTNPs) were completely immobile, the presence of CMC significantly enhanced their mobility. The magnitude of the surface charge exhibited by the CMC-coated anatase TiO(2) nanoparticles (CMC-ANTNPs) significantly exceeded that of the uncoated ANTNPs, thereby leading to a negative surface charge over the pH range investigated (2-10). The mobility of CMC-ANTNPs was retarded by the presence of amorphous Fe and Al hydroxide, Na(+) (30 mM), and Ca(2+) (30 mM). Removal of CMC-ANTNPs was more significant in the presence of either Ca(2+) or Fe-hydroxide. More retardation and incomplete breakthrough of the CMC-ANTNPs was observed in the mineral-coated sands. This is possibly due to an order of magnitude increase in the surface area of miner l-coated sands compared with the clean quartz sand grains and the potential for chelation between CMC bound to ANTNPs and Fe and Al hydroxides. Chemical-colloidal interactions such as chemicomplexation and ligand exchange were the most important factor controlling mobility of CMC-ANTNPs in mineral-coated sands.
C1 [Al-Abed, Souhail R.; Luxton, Todd] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Joo, Sung Hee] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA.
RP Al-Abed, SR (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM al-abed.souhail@epa.gov
FU U.S, Environmental Protection Agency (EPA), Cincinnati, Ohio; Ohio Board
of Reagents
FX This research was funded by and conducted at the National Risk
Management Research Laboratory of U.S, Environmental Protection Agency
(EPA), Cincinnati, Ohio. This paper has not been subjected to internal
policy review of the U.S. EPA. Therefore, the research results do not
necessarily reflect the views of the agency or its policy. Mention of
trade names and commercial products does not constitute endorsement or
recommendation for use. We acknowledge Dr. Dionysios Dionysiou Of the
University of Cincinnati for providing access to use the Tristar 3000
BET-surface area analyzer that was funded by Ohio Board of Reagents, and
Mr. Miguel Pelaez for his assistance for surface area measurement. Dr.
Mallikarjuna Nadagouda is acknowledged for performing XRD and EDX
analysis. We greatly appreciate the insightful comments of three
anonymous reviewers.
NR 40
TC 45
Z9 47
U1 4
U2 27
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JUL 1
PY 2009
VL 43
IS 13
BP 4954
EP 4959
DI 10.1021/es900329d
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 463ME
UT WOS:000267435500053
PM 19673291
ER
PT J
AU Yuan, LL
Pollard, AI
Carlisle, DM
AF Yuan, Lester L.
Pollard, Amina I.
Carlisle, Daren M.
TI USING PROPENSITY SCORES TO ESTIMATE THE EFFECTS OF INSECTICIDES ON
STREAM INVERTEBRATES FROM OBSERVATIONAL DATA
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Insecticides; Observational data; Propensity scores; Streams;
Macroinvertebrates
ID FEDERALLY-MANDATED BAN; MACROINVERTEBRATE COMMUNITY; CAUSAL INFERENCE;
SURFACE WATERS; LAND-USE; RESPONSES; RECOVERY; CONTAMINATION;
CHLORPYRIFOS; DISTURBANCE
AB Analyses of observational data can provide insights into relationships between environmental conditions and biological responses across a broader range of natural conditions than experimental studies, potentially complementing insights gained from experiments. However, observational data must be analyzed carefully to minimize the likelihood that confounding variables bias observed relationships. Propensity scores provide a robust approach for controlling for the effects of measured confounding variables when analyzing observational data. Here, we use propensity scores to estimate changes in mean invertebrate taxon richness in streams that have experienced insecticide concentrations that exceed aquatic life use benchmark concentrations. A simple comparison of richness in sites exposed to elevated insecticides with those that were not exposed suggests that exposed sites had on average 6.8 fewer taxa compared to unexposed sites. The presence of potential confounding variables makes it difficult to assert a causal relationship from this simple comparison. After controlling for confounding factors using propensity scores, the difference in richness between exposed and unexposed sites was reduced to 4.1 taxa, a difference that was still statistically significant. Because the propensity score analysis controlled for the effects of a wide variety of possible confounding variables, we infer that the change in richness observed in the propensity score analysis was likely caused by insecticide exposure.
C1 [Yuan, Lester L.; Pollard, Amina I.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
[Carlisle, Daren M.] US Geol Survey, Natl Water Qual Assessment Program, Reston, VA 20192 USA.
RP Yuan, LL (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, 1200 Penn Ave NW,Mail Code 8623P, Washington, DC 20460 USA.
EM yuan.lester@epa.gov
NR 43
TC 2
Z9 2
U1 1
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD JUL
PY 2009
VL 28
IS 7
BP 1518
EP 1527
PG 10
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 457XM
UT WOS:000266969500021
PM 19215187
ER
PT J
AU Baird, DD
Travlos, G
Wilson, R
Dunson, DB
Hill, MC
D'Aloisio, AA
London, SJ
Schectman, JM
AF Baird, Donna D.
Travlos, Greg
Wilson, Ralph
Dunson, David B.
Hill, Michael C.
D'Aloisio, Aimee A.
London, Stephanie J.
Schectman, Joel M.
TI Uterine Leiomyomata in Relation to Insulin-like Growth Factor-I,
Insulin, and Diabetes
SO EPIDEMIOLOGY
LA English
DT Article
ID FACTOR-BINDING PROTEINS; SMOOTH-MUSCLE TISSUES; IGF-I; TUMORIGENIC
FACTORS; EXPRESSION PROFILE; HUMAN MYOMETRIUM; GENE-EXPRESSION;
BREAST-CANCER; RISK-FACTORS; WOMEN
AB Background: Insulin-like growth factor-I (IGF-I) and insulin stimulate cell proliferation in uterine leiomyoma (fibroid) tissue. We hypothesized that circulating levels of these proteins would be associated with increased prevalence and size of uterine fibroids.
Methods: Participants were 35-49-year-old, randomly selected members of an urban health plan who were enrolled in the study in 1996-1999. Premenopausal participants were screened for fibroids with ultrasound. Fasting blood samples were collected. Associations between fibroids and diabetes, plasma IGF-I, IGF binding protein 3 (BP3), and insulin were evaluated for blacks (n = 585) and whites (n 403) by using multiple logistic regression.
Results: IGF-I showed no association with fibroids in blacks, but in whites the adjusted odds ratios (aORs) for both mid and upper tertiles compared with the lowest tertile were 0.6 (95% confidence intervals [CI] = 0.3-1.0 and 0.4-1.1, respectively). Insulin and diabetes both tended to be inversely associated with fibroids in blacks. The insulin association was with large fibroids; aOR for the upper insulin tertile relative to the lowest was 0.4 (0.2-0.9). The aOR for diabetes was 0.5 (0.2-1.0). Associations of insulin and diabetes with fibroids were weak for whites. Binding protein 3 showed no association with fibroids.
Conclusions: Contrary to our hypothesis, high circulating IGF-I and insulin were not related to increased fibroid prevalence. Instead, there was suggestion of the opposite. The inverse association with diabetes, although based on small numbers, is consistent with previously reported findings. Future studies might investigate vascular dysfunction as a mediator between hyperinsulinemia or diabetes and possible reduced risk of fibroids. (Epidemiology 2009-120: 604-610)
C1 [Baird, Donna D.; D'Aloisio, Aimee A.; London, Stephanie J.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
[Travlos, Greg; Wilson, Ralph] Natl Inst Environm Hlth Sci, Clin Pathol Grp, Res Triangle Pk, NC 27709 USA.
[Dunson, David B.] Natl Inst Environm Hlth Sci, Biostat Branch, Res Triangle Pk, NC 27709 USA.
[Hill, Michael C.] George Washington Univ, Med Ctr, Dept Radiol, Washington, DC 20037 USA.
[Schectman, Joel M.] George Washington Univ, Med Ctr, Dept Hlth Care Sci, Washington, DC 20037 USA.
RP Baird, DD (reprint author), Natl Inst Environm Hlth Sci, Epidemiol Branch, A3-05,111 TW Alexander,Bldg 101,Rm 308,POB 12233, Res Triangle Pk, NC 27709 USA.
EM baird@niehs.nih.gov
RI Baird, Donna/D-5214-2017;
OI Baird, Donna/0000-0002-5544-2653; London, Stephanie/0000-0003-4911-5290
FU Office of Research on Minority Health; National Institutes of Health;
HHS
FX Supported by the intramural program at the National Institute of
Environmental Health Sciences with support from the Office of Research
on Minority Health, National Institutes of Health, HHS.
NR 41
TC 15
Z9 15
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
J9 EPIDEMIOLOGY
JI Epidemiology
PD JUL
PY 2009
VL 20
IS 4
BP 604
EP 610
DI 10.1097/EDE.0b013e31819d8d3f
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 458YJ
UT WOS:000267065500020
PM 19305350
ER
PT J
AU Boothman, WS
Coiro, LL
AF Boothman, Warren S.
Coiro, Laura L.
TI Laboratory Determination of Molybdenum Accumulation Rates as a Measure
of Hypoxic Conditions
SO ESTUARIES AND COASTS
LA English
DT Article
DE Molybdenum; Sediments; Dissolved oxygen; Hypoxia
ID CONTINENTAL-MARGIN SEDIMENTS; MARINE-SEDIMENTS; CHESAPEAKE BAY;
TRACE-METALS; URANIUM; MO; GEOCHEMISTRY; RHENIUM; WATERS; RE
AB Enrichment of molybdenum (Mo) in reducing sediments due to authigenic fixation in anoxic interstitial waters could provide an indicator of hypoxic conditions that integrates over substantial temporal extents. Sediments maintained under controlled dissolved oxygen (DO) conditions showed elevated concentrations of Mo when exposed to low DO concentrations. Mo accumulation was linearly related to time of exposure in treatments below 2.8 mg O(2)/L, with less or no accumulation at higher concentrations. Rates of accumulation were independent of DO concentration below 2.8 mg/L. Accumulation occurred at DO concentrations higher than those limiting accumulation in field settings, with rates in the lowest treatments similar to those in sediments of deep basins with restricted circulation and low DO concentrations.
C1 [Boothman, Warren S.; Coiro, Laura L.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Boothman, WS (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
EM boothman.warren@epa.gov
NR 36
TC 4
Z9 4
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
J9 ESTUAR COAST
JI Estuaries Coasts
PD JUL
PY 2009
VL 32
IS 4
BP 642
EP 653
DI 10.1007/s12237-009-9163-y
PG 12
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 456CE
UT WOS:000266815300004
ER
PT J
AU Urich, D
Soberanes, S
Burgess, Z
Chiarella, SE
Ghio, AJ
Ridge, KM
Kamp, DW
Chandel, NS
Mutlu, GM
Budinger, GRS
AF Urich, Daniela
Soberanes, Saul
Burgess, Zach
Chiarella, Sergio E.
Ghio, Andrew J.
Ridge, Karen M.
Kamp, David W.
Chandel, Navdeep S.
Mutlu, Goekhan M.
Budinger, G. R. Scott
TI Proapoptotic Noxa is required for particulate matter-induced cell death
and lung inflammation
SO FASEB JOURNAL
LA English
DT Article
DE apoptosis; oxidant; bax; air pollution
ID LONG-TERM EXPOSURE; AIR-POLLUTION; MEDICARE BENEFICIARIES; APOPTOSIS;
MORTALITY; PARTICLES; PATHWAY; DISEASE; HEALTH; CITIES
AB Elevated ambient levels of particulate matter air pollution are associated with excess daily mortality, largely attributable to increased rates of cardiovascular events. We have previously reported that particulate matter induces p53-dependent apoptosis in primary human alveolar epithelial cells. Activation of the intrinsic apoptotic pathway by p53 often requires the transcription of the proapoptotic Bcl-2 proteins Noxa, Puma, or both. In this study, we exposed alveolar epithelial cells in culture and mice to fine particulate matter <2.5 mu m in diameter (PM2.5) collected from the ambient air in Washington, D. C. Exposure to PM2.5 induced apoptosis in primary alveolar epithelial cells from wild-type but not Noxa(-/-) mice. Twenty-four hours after the intratracheal instillation of PM2.5, wildtype mice showed increased apoptosis in the lung and increased levels of mRNA encoding Noxa but not Puma. These changes were associated with increased permeability of the alveolar-capillary membrane and inflammation. All of these findings were absent or attenuated in Noxa(-/-) animals. We conclude that PM(2.5)-induced cell death requires Noxa both in vitro and in vivo and that Noxa-dependent cell death might contribute to PM-induced alveolar epithelial dysfunction and the resulting inflammatory response.-Urich, D., Soberanes, S., Burgess, Z., Chiarella, S. E., Ghio, A. J., Ridge, K. M., Kamp, D. W., Chandel, N. S., Mutlu, G. M., Budinger, G. R. S. Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation. FASEB J. 23, 2055-2064 (2009)
C1 [Urich, Daniela; Soberanes, Saul; Burgess, Zach; Chiarella, Sergio E.; Ridge, Karen M.; Kamp, David W.; Chandel, Navdeep S.; Mutlu, Goekhan M.; Budinger, G. R. Scott] Northwestern Univ, Div Pulm & Crit Care Med, Feinberg Sch Med, Chicago, IL 60611 USA.
[Ghio, Andrew J.] US EPA, Res Triangle Pk, NC 27711 USA.
RP Budinger, GRS (reprint author), Northwestern Univ, Div Pulm & Crit Care Med, Feinberg Sch Med, 240 E Huron,McGaw Pavil M300, Chicago, IL 60611 USA.
EM s-buding@northwestern.edu
FU NIH [HL071643, GM060472, HL067835, ES015024, ES013995]; The American
Lung Association
FX The authors thank Dr. Jacob Sznajder and Dr. David Green for their
advice during the performance of these experiments and preparation of
the manuscript. This work was supported by NIH grants HL071643,
GM060472, HL067835, ES015024, and ES013995, and by The American Lung
Association.
NR 44
TC 20
Z9 22
U1 1
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD JUL
PY 2009
VL 23
IS 7
BP 2055
EP 2064
DI 10.1096/fj.08-114546
PG 10
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA 481UC
UT WOS:000268836500006
PM 19237507
ER
PT J
AU Che-Alota, V
Atekwana, EA
Atekwana, EA
Sauck, WA
Werkema, DD
AF Che-Alota, Vukenkeng
Atekwana, Estella A.
Atekwana, Eliot A.
Sauck, William A.
Werkema, D. Dale, Jr.
TI Temporal geophysical signatures from contaminant-mass remediation
SO GEOPHYSICS
LA English
DT Article
DE electrical conductivity; ground penetrating radar; groundwater;
hydrological techniques; soil; soil pollution; water pollution
ID BULK ELECTRICAL-CONDUCTIVITY; GROUND-PENETRATING RADAR; LNAPL PLUME;
CHLORINATED SOLVENTS; ATTENUATION ANALYSIS; NATURAL ATTENUATION;
ACCEPTING PROCESSES; ANOXIC GROUNDWATER; DC RESISTIVITY; CRUDE-OIL
AB We have previously documented changes in bulk electrical conductivity, self-potential (SP), and ground-penetrating-radar (GPR) reflections in a field setting caused by biogeochemical transformations of hydrocarbon-contaminated media. These transformations are associated with hydrocarbon biodegradation. The results of surface geophysical surveys acquired in 1996, 2003, and 2007 document changes in geophysical signatures associated with removing hydrocarbon mass in the contaminated zone. Initial investigations in 1996 showed that relative to background, the contaminated area was characterized by higher bulk electrical conductivity, positive SP anomaly, and attenuated GPR reflections. Repeated surveys in 2003 and 2007 over the contaminated area showed that in 2007, the bulk electrical conductivityhad reverted to near-background conditions, the positive SP anomaly became more negative, and the zone of attenuated GPR reflections showed increased signal strength. Removal of hydrocarbon mass in the vadose zone over the plume by a soil vapor-extraction system installed in 2001 was primarily responsible for the changing geophysical responses. Although chemical data from groundwater showed a 3-m-thick con-ductive plume in 2007, the plume was not imaged by elec-trical resistivity. Forward modeling suggests that apparent bulk electrical conductivity of the saturated zone plume has to be three to five times higher than background values to be imaged by electrical resistivity. We suggest that removing hydrocarbon-contaminant-mass reduction by natural or engineered bioremediation can be imaged effectively by temporal geophysical surveys.
C1 [Che-Alota, Vukenkeng; Atekwana, Estella A.; Atekwana, Eliot A.] Oklahoma State Univ, Boone Pickens Sch Geol, Stillwater, OK 74078 USA.
[Sauck, William A.] Western Michigan Univ, Dept Geosci, Kalamazoo, MI 49008 USA.
[Werkema, D. Dale, Jr.] US EPA, Off Res & Dev, Las Vegas, NV USA.
RP Che-Alota, V (reprint author), Oklahoma State Univ, Boone Pickens Sch Geol, Stillwater, OK 74078 USA.
EM vukenkeng.che_alota@okstate.edu; estella.atekwana@okstate.edu;
eliot.atekwana@okstate.edu; bill.sauck@wmich.edu;
werkema.d@epamail.epa.gov
OI atekwana, eliot/0000-0002-4934-650X; Sauck, William/0000-0003-2911-3044
FU National Science Foundation [EAR-0651433, OCE 0433869, OCE 0729642]; U.
S. Environmental Protection Agency (EPA) [RFQ-RT-07-00183A]
FX Partial funding for this work was provided by the National Science
Foundation (grants EAR-0651433, OCE 0433869, and OCE 0729642) and the U.
S. Environmental Protection Agency (EPA), grant RFQ-RT-07-00183A. The
EPA, through its Office of Research and Development, funded and
collaborated in the research described here under RFQ-RT-07-00183A to V.
Che-Alota. It has been subjected to agency review and approved for
publication. We thank Wurtsmith Air Force Base authorities and Paul
Rekowski for allowing us access to the site. Charles Major provided the
historical groundwater chemistry data. We thank Caroline Davis, Jay
Nolan, Ryan Joyce, Silvia Rossbach, and Gamal Abdel Aal for their help
with data collection and processing. We also thank four anonymous
reviewers whose comments helped to improve this manuscript.
NR 52
TC 11
Z9 12
U1 1
U2 9
PU SOC EXPLORATION GEOPHYSICISTS
PI TULSA
PA 8801 S YALE ST, TULSA, OK 74137 USA
SN 0016-8033
J9 GEOPHYSICS
JI Geophysics
PD JUL-AUG
PY 2009
VL 74
IS 4
BP B113
EP B123
DI 10.1190/1.3139769
PG 11
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA 465PO
UT WOS:000267599500009
ER
PT J
AU Havel, JE
Medley, KA
Dickerson, KD
Angradi, TR
Bolgrien, DW
Bukaveckas, PA
Jicha, TM
AF Havel, John E.
Medley, Kim A.
Dickerson, Kelli D.
Angradi, Theodore R.
Bolgrien, David W.
Bukaveckas, Paul A.
Jicha, Terri M.
TI Effect of main-stem dams on zooplankton communities of the Missouri
River (USA)
SO HYDROBIOLOGIA
LA English
DT Article
DE Rotifers; Copepods; Cladocerans; Reservoirs; Regulated rivers
ID PLANKTONIC ROTIFERS; OHIO RIVER; ABUNDANCE; RESERVOIR; PHYTOPLANKTON;
ASSEMBLAGES; DIVERSITY; HYDROLOGY; PREDATION; DYNAMICS
AB The persistence of plankton in flowing water presents an enigma, i.e., how can populations be sustained while constantly losing individuals downriver? We examined the distribution and abundance of zooplankton from 146 sites on the Missouri River (USA) and found large shifts in the dominance of major taxa between management zones of this regulated river. Crustacean zooplankton were dominant in the inter-reservoir zone of the river, and their taxonomic composition was similar to regional lakes and reservoirs. The exponential decline of cladocerans and copepods with distance from main-stem dams suggests that conditions within the river are adverse to population growth and that reservoirs are the main source of these crustaceans in the river. Rotifers dominated in the channelized zone of the river. High algal biomass and rapid population growth rates likely allow persistence of rotifers in segments of the river that do not receive direct reservoir inputs. Rotifers were less abundant in the inter-reservoir zone, suggesting that their numbers are limited by internal processes, such as food or predators. Since zooplankton are known to be an important food for larval fishes in rivers, this shift of major taxa in regulated rivers has implications for river food webs.
C1 [Havel, John E.; Medley, Kim A.; Dickerson, Kelli D.] Missouri State Univ, Dept Biol, Springfield, MO 65897 USA.
[Angradi, Theodore R.; Bolgrien, David W.; Jicha, Terri M.] US EPA, Mid Continent Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Duluth, MN 55804 USA.
[Bukaveckas, Paul A.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA.
RP Havel, JE (reprint author), Missouri State Univ, Dept Biol, 901 S Natl Ave, Springfield, MO 65897 USA.
EM johnhavel@missouristate.edu
OI Bukaveckas, Paul/0000-0002-2636-7818
FU U.S. Environmental Protection Agency through Environmental Monitoring
and Assessment Program
FX Funding for this project was provided by the U.S. Environmental
Protection Agency, through its Environmental Monitoring and Assessment
Program (EMAP, http://www.epa.gov/emap/) for Great River Ecosystems. A
project of this scale would not have been possible without the
assistance of many individuals. We especially thank the three field
crews for collecting samples and physico-chemical data from the Missouri
River, and Jason Wolf and Carla Atkinson (MSU) for sampling the
tributaries. We also appreciate the many insights gained from our
discussions with EMAP collaborators, particularly John Chick, Anthony
Aufdenkampe, Dave Walters, and the late Jeffrey Jack. The paper
benefited from the careful insights of three anonymous reviewers.
NR 50
TC 16
Z9 23
U1 1
U2 20
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0018-8158
J9 HYDROBIOLOGIA
JI Hydrobiologia
PD JUL
PY 2009
VL 628
IS 1
BP 121
EP 135
DI 10.1007/s10750-009-9750-8
PG 15
WC Marine & Freshwater Biology
SC Marine & Freshwater Biology
GA 444VG
UT WOS:000266007900009
ER
PT J
AU Harbut, MR
Endress, C
Graff, JJ
Weis, C
Pass, H
AF Harbut, Michael R.
Endress, Carmen
Graff, John J.
Weis, Christopher
Pass, Harvey
TI Clinical Presentation of Asbestosis with Intractable Pleural Pain in the
Adult Child of a Taconite Miner and Radiographic Demonstration of the
Probable Pathology Causing the Pain
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE taconite; pleuritic pain; asbestosis; asbestos-related disease; image
processing; computer-assisted
ID AIRBORNE ASBESTOS; BUILDINGS
AB Taconite, although not classified by the United States Government as asbestos or asbestiform material, has been associated with asbestos-related diseases. The mineral is used in the production of steel and as a road-patch material and is mined in Michigan and Minnesota. This report describes the case of a middle-aged Caucasian woman with exposure to taconite mining dust from her miner father's clothing in childhood with a resultant presentation consistent with asbestosis and intractable pleural pain. Intractable Pleural pain has been described in asbestos-exposed patients with theorized etiologies. However, no in, vivo reported mechanism has demonstrated a plausible, anatomically apparent mechanism for the pain. We utilize an application of the Vitrea (R) software for enhancement of high-resolution computerized tomography which demonstrates at least one likely mechanism for intractable pleural pain.
C1 [Harbut, Michael R.; Endress, Carmen; Graff, John J.] Wayne State Univ, Sch Med, Karmanos Canc Inst, Detroit, MI 48201 USA.
[Weis, Christopher] US EPA, Natl Enforcement Invest Ctr, Denver, CO USA.
[Pass, Harvey] NYU, Dept Thorac Surg, New York, NY USA.
RP Graff, JJ (reprint author), Wayne State Univ, Sch Med, Karmanos Canc Inst, 110 E Warren Ave, Detroit, MI 48201 USA.
EM graffj@karmanos.org
NR 15
TC 1
Z9 1
U1 0
U2 3
PU ABEL PUBLICATION SERVICES
PI BURLINGTON
PA 1611 AQUINAS COURT, BURLINGTON, NC 27215 USA
SN 1077-3525
J9 INT J OCCUP ENV HEAL
JI Int. J. Occup. Environ. Health
PD JUL-SEP
PY 2009
VL 15
IS 3
BP 269
EP 273
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 475MC
UT WOS:000268362600005
PM 19650581
ER
PT J
AU Schock, MR
Sandvig, AM
AF Schock, Michael R.
Sandvig, Anne M.
TI Long-term effects of orthophosphate treatment on copper concentration
SO JOURNAL AMERICAN WATER WORKS ASSOCIATION
LA English
DT Article
ID BY-PRODUCT RELEASE
AB Lead and Copper Rule (LCR) compliance monitoring is intentionally biased toward sites that exhibit elevated lead rather than elevated copper, but water utilities-especially those with higher percentages of newer copper piping-need to be aware that copper concentrations above the action level (AL) may be present in their systems. Orthophosphate doses at sufficient concentrations can help high-alkalinity groundwater systems (even those with new plumbing) meet the copper AL.
The theoretical cupric-hydroxide copper-solubility model predicts that as pipe ages, tenorite or malachite forms and predominates as the surface phase, lowering copper levels. Orthophosphate dosing, however, can prevent the reduction of copper solubility over years and decades, with the result that systems which do not use corrosion inhibitors likely will experience copper levels lower than what would be achieved with orthophosphate. Using the information presented here, water suppliers will be better able to evaluate the tradeoff between orthophosphate treatment versus pH and/or alkalinity adjustment to meet the LCR.
C1 [Schock, Michael R.] US EPA, Water Supply & Water Resources Div, Cincinnati, OH 45220 USA.
RP Schock, MR (reprint author), US EPA, Water Supply & Water Resources Div, 26 W Martin Luther King Dr, Cincinnati, OH 45220 USA.
EM schock.michael@epa.gov
NR 16
TC 8
Z9 8
U1 0
U2 5
PU AMER WATER WORKS ASSOC
PI DENVER
PA 6666 W QUINCY AVE, DENVER, CO 80235 USA
SN 0003-150X
J9 J AM WATER WORKS ASS
JI J. Am. Water Work Assoc.
PD JUL
PY 2009
VL 101
IS 7
BP 71
EP +
PG 13
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA 473IN
UT WOS:000268199700010
ER
PT J
AU Pleim, JE
Gilliam, R
AF Pleim, Jonathan E.
Gilliam, Robert
TI An Indirect Data Assimilation Scheme for Deep Soil Temperature in the
Pleim-Xiu Land Surface Model
SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY
LA English
DT Article
ID MESOSCALE METEOROLOGICAL MODEL; ATMOSPHERIC BOUNDARY-LAYER; NONLOCAL
CLOSURE-MODEL; LOW-LEVEL PARAMETERS; FORCE-RESTORE METHOD; PART I;
SEQUENTIAL ASSIMILATION; MOISTURE; IMPLEMENTATION; PREDICTION
AB The Pleim-Xiu land surface model (PX LSM) has been improved by the addition of a second indirect data assimilation scheme. The first, which was described previously, is a technique in which soil moisture is nudged according to the biases in 2-m air temperature and relative humidity between the model-and observation-based analyses. The new technique involves nudging the deep soil temperature in the soil temperature force restore (FR) model according to model bias in 2-m air temperature only during nighttime. While the FR technique is computationally efficient and very accurate for the special conditions for which it was derived, it is very dependent on the deep soil temperature that drives the restoration term of the surface soil temperature equation. Thus, adjustment of the deep soil temperature to optimize the 2-m air temperature during the night, when surface forcing is minimal, provides significant advantages over other methods of deep soil moisture initialization. Simulations of the Weather Research and Forecasting Model (WRF) using the PX LSM with and without the new deep soil temperature nudging scheme demonstrate substantial benefits of the new scheme for reducing error and bias of the 2-m air temperature. The effects of the new nudging scheme are most pronounced in the winter (January 2006) during which the model's cold bias is greatly reduced. Air temperature error and bias are also reduced in a summer simulation (August 2006) with the greatest benefits in less vegetated and more arid regions. Thus, the deep temperature nudging scheme complements the soil moisture nudging scheme because it is most effective for conditions in which the soil moisture scheme is least effective, that is, when evapotranspiration is not important (winter and arid climates).
C1 [Pleim, Jonathan E.; Gilliam, Robert] US EPA, Atmospher Modeling Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Pleim, JE (reprint author), 1003 Alden Bridge Dr, Cary, NC 27519 USA.
EM pleim.jon@epa.gov
RI Pleim, Jonathan Pleim/C-1331-2017
OI Pleim, Jonathan Pleim/0000-0001-6190-6082
FU U.S. Environmental Protection Agency through its Office of Research and
Development
FX The U.S. Environmental Protection Agency through its Office of Research
and Development funded and managed the research described here. It has
been subjected to Agency review and approved for publication.
NR 35
TC 34
Z9 34
U1 3
U2 10
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 1558-8424
J9 J APPL METEOROL CLIM
JI J. Appl. Meteorol. Climatol.
PD JUL
PY 2009
VL 48
IS 7
BP 1362
EP 1376
DI 10.1175/2009JAMC2053.1
PG 15
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 474NS
UT WOS:000268291700006
ER
PT J
AU Menetrez, MY
Foarde, KK
Webber, TD
Dean, TR
Betancourt, DA
AF Menetrez, M. Y.
Foarde, K. K.
Webber, T. D.
Dean, T. R.
Betancourt, D. A.
TI Mold Growth on Gypsum Wallboard-A Summary of Three Techniques
SO JOURNAL OF ENVIRONMENTAL HEALTH
LA English
DT Article
ID STACHYBOTRYS-CHARTARUM; PULMONARY HEMORRHAGE; EFFICACY
AB Reducing occupant exposure to mold growing on damp gypsum wallboard and controlling mold contamination in the indoor environment was studied through 1) delineation of environmental conditions required to promote and avoid mold growth and 2) efficacy testing of antimicrobial products, specifically cleaners and paints, on gypsum wallboard (GWB) surfaces. The effects of moisture and relative humidity (RH) on mold growth and transport are important in avoiding and eliminating problems. These effects have been demonstrated on GWB and are discussed in this article for use as control guidance. The authors discuss the efficacy of antimicrobial cleaners and paints to remove, eliminate, or control mold growth on GWB. Research to control Stachybotrys chartarum growth using 13 separate antimicrobial cleaners and nine varieties of antimicrobial paint on contaminated GWB was performed in laboratory testing. GWB surfaces were subjected to high RE GWB control measures are summarized and combined, and the antimicrobial product results are explained.
C1 [Menetrez, M. Y.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Res Triangle Pk, NC 27711 USA.
RP Menetrez, MY (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Air Pollut Prevent & Control Div, Res Triangle Pk, NC 27711 USA.
EM menetrez.marc@epa.gov
NR 10
TC 2
Z9 2
U1 0
U2 5
PU NATL ENVIRON HEALTH ASSOC
PI DENVER
PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA
SN 0022-0892
J9 J ENVIRON HEALTH
JI J. Environ. Health
PD JUL-AUG
PY 2009
VL 72
IS 1
BP 24
EP 28
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 471WP
UT WOS:000268089300005
PM 19681385
ER
PT J
AU Walker, JT
Vose, JM
Knoepp, J
Geron, CD
AF Walker, John T.
Vose, James M.
Knoepp, Jennifer
Geron, Christopher D.
TI Recovery of Nitrogen Pools and Processes in Degraded Riparian Zones in
the Southern Appalachians
SO JOURNAL OF ENVIRONMENTAL QUALITY
LA English
DT Article
ID SOIL PHYSICAL-PROPERTIES; NITRIC-OXIDE; AMMONIA VOLATILIZATION; GRAZED
SWARDS; WATER-QUALITY; EMISSIONS; MODEL; ATMOSPHERE; AUSTRALIA; DYNAMICS
AB Establishment of riparian buffers is an effective method For reducing nutrient input to streams. However, the underlying biogeochemical processes are not fully understood. The objective of this 4-yr study was to examine the effects of riparian zone restoration on soil N cycling mechanisms in a mountain pasture previously degraded by cattle. Soil inorganic N Pools, fluxes, and transformation mechanisms were compared across the following experimental treatments: (i) a restored area with vegetation regrowth; (ii) a degraded riparian area with simulated effects of continued grazing by compaction, vegetation removal, and nutrient addition (+N); and (iii) a degraded riparian area with simulated compaction and vegetation removal only (-N). Soil solution NO(3)(-) concentrations and fluxes of inorganic N in overland flow were >90% lower in the restored treatment relative to the degraded (+N) treatment. Soil solution NO(3)(-) concentrations decreased more rapidly in the restored treatment relative to the degraded (-N) following cattle (Bos taurus) exclusion. Mineralization and nitrification rates in the restored treatment were similar to the degraded (-N) treatment and, on average, 75% lower than in the degraded (+N) treatment. Nitrogen trace gas fluxes indicated chat restoration increased the relative importance of denitrification, relative to nitrification, as a pathway by which N is diverted from the receiving stream to the atmosphere. Changes in soil nutrient cycling mechanisms following restoration of the degraded riparian zone were primarily driven by cessation of N inputs. The recovery rate, however, was influenced by the rate of vegetation regrowth.
C1 [Walker, John T.; Geron, Christopher D.] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Vose, James M.; Knoepp, Jennifer] US Forest Serv, USDA, Coweeta Hydrol Lab, Otto, NC 28763 USA.
RP Walker, JT (reprint author), US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
EM walker.johnt@epa.gov
RI Walker, John/I-8880-2014
OI Walker, John/0000-0001-6034-7514
FU U.S. Environmental Protection Agency; National Risk Management Research
Laboratory; Research Triangle Park, NC
FX We appreciate the technical support of Wayne Fowler (U.S. EPA) and Bill
Preston (U.S. EPA). We also thank Siler Slagle for site access. Mention
of trade names does not constitute endorsement or recommendation of a
commercial product by U.S. EPA or the U.S. Department of Agriculture.
This research was partially funded by the U.S. Environmental Protection
Agency, National Risk Management Research Laboratory, Research Triangle
Park, NC.
NR 40
TC 6
Z9 6
U1 1
U2 13
PU AMER SOC AGRONOMY
PI MADISON
PA 677 S SEGOE RD, MADISON, WI 53711 USA
SN 0047-2425
J9 J ENVIRON QUAL
JI J. Environ. Qual.
PD JUL-AUG
PY 2009
VL 38
IS 4
BP 1391
EP 1399
DI 10.2134/jeq2008.0259
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 467EG
UT WOS:000267719800005
PM 19465714
ER
PT J
AU Floyd, WC
Schoenholtz, SH
Griffith, SM
Wigington, PJ
Steiner, JJ
AF Floyd, William C.
Schoenholtz, Stephen H.
Griffith, Stephen M.
Wigington, Parker J., Jr.
Steiner, Jeffrey J.
TI Nitrate-Nitrogen, Land Use/Land Cover, and Soil Drainage Associations at
Multiple Spatial Scales
SO JOURNAL OF ENVIRONMENTAL QUALITY
LA English
DT Article
ID WATER-QUALITY; AGRICULTURAL STREAM; RIPARIAN ZONES; PERSPECTIVE; FOREST;
ATTRIBUTES; PHOSPHORUS; MANAGEMENT; PROXIMITY; CATCHMENT
AB Managing non-point-source pollution of water requires knowledge of land use/land cover (LULC) influences at altering watershed scales. To gain improved understanding of relationships among LULC, Soil drainage, and dissolved nitrate-N dynamics within the Calapooia River Basin in western Oregon, we selected 44 watersheds ranging in size between 3 and 33 km(2) for monthly synoptic sampling of surface water quality between October 2003 and September 2004. Seasonal associations were examined between dissolved nicrate-N and proportion of woody vegetation or poorly drained soils at differing scales (10, 20, 30, 60, 90, 150, 300 m, and entire watershed), which we defined as influence zones (IZs), surrounding stream networks. Correlations between nitrate-N and proportion woody vegetation or poorly drained soil at each IZ were analyzed for differences using the Hotelling-Williams test. We observed negative correlations (r = -0.81 to -0.94) between nitrate-N and proportion of woody vegetation during winter and spring. Poorly drained soils had positive correlations (r = 0.63-0.87) with nitrate-N. Altering the scale of analysis significantly changed correlations between nitrare-N and woody vegetation, with IZs < 150 m being stronger than the watershed scale during winter. However, absolute differences in correlation values were small, indicating minimal ecological consequence for significant differences among scales. In contrast, nitrate-N correlations with poorly drained soil were stronger at the watershed scale than the 10- through 90-m IZs during winter and spring, and absolute differences were sufficient to suggest that scale is ecologically important when determining associations between dissolved nitrate-N and poorly drained soils.
C1 [Floyd, William C.; Schoenholtz, Stephen H.] Oregon State Univ, Dep Forest Engn Resources & Management, Corvallis, OR 97331 USA.
[Griffith, Stephen M.] USDA ARS, Natl Forage Seed Prod Res Ctr, Blacksburg, VA 24061 USA.
[Wigington, Parker J., Jr.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
[Steiner, Jeffrey J.] USDA ARS, Off Natl Programs, Beltsville, MD 20705 USA.
RP Schoenholtz, SH (reprint author), Virginia Tech, Virginia Water Resources Res Ctr, 210 Cheatham Hall, Blacksburg, VA 24061 USA.
EM stephen.schoenholtz@vt.edu
FU Forest Research Laboratory at Oregon State University; USDA Agricultural
Research Service
FX The research reported in this paper was funded by the Forest Research
Laboratory at Oregon State University and the USDA Agricultural Research
Service. The US Environmental Protection Agency provided in-kind support
through the time of one of the co-authors. This paper has been subject
to Agency review and approved for publication. Reference to trade names
does not imply endorsement by the US Government. John Van Sickles
statistical contributions and technical support of Machelle Nelson mid
Donald Streeter are greatly appreciated. Field work was aided by Rebecca
L'Hirondelle, Daniel Evans, and Chad Davis. Maryanne Reiter and Denise
Hoffert-Hay were instrumental in providing landowner access and records.
This paper benefited significantly from comments of Journal of
Environmental Quality Associate Editor Larry Puckett and two anonymous
reviewers.
NR 45
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U1 2
U2 16
PU AMER SOC AGRONOMY
PI MADISON
PA 677 S SEGOE RD, MADISON, WI 53711 USA
SN 0047-2425
J9 J ENVIRON QUAL
JI J. Environ. Qual.
PD JUL-AUG
PY 2009
VL 38
IS 4
BP 1473
EP 1482
DI 10.2134/jeq2008.0099
PG 10
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 467EG
UT WOS:000267719800014
PM 19465723
ER
PT J
AU Impellitteri, CA
Tolaymat, TM
Scheckel, KG
AF Impellitteri, Christopher A.
Tolaymat, Thabet M.
Scheckel, Kirk G.
TI The Speciation of Silver Nanoparticles in Antimicrobial Fabric Before
and After Exposure to a Hypochlorite/Detergent Solution
SO JOURNAL OF ENVIRONMENTAL QUALITY
LA English
DT Article
AB Because of their antibacterial properties, silver nanoparticles are often used in consumer products. To assess environmental and/or human health risks from these nanoparticles, there is a need to identify the chemical transformations chat silver nanoparticles undergo in different environments. Thus an antimicrobial sock material containing Ag nanoparticles was examined by X-ray absorption spectroscopy to identify the speciation of Ag. The material was exposed to a hypochlorite/ detergent solution and subjected to agitation. An elemental Ag nanopowder was also exposed to the hypochlorite/detergent solution or to a 1 mol L(-1) NaCl solution. Results showed that the sock material nanoparticles consisted of elemental Ag. After exposure to the hypochlorite/detergent Solution, a significant portion (more than 50%) of the sock nanoparticles were converted, in situ, to AgCl. Results from exposures to elemental Ag nanopowder suggest that an oxidation step is necessary for the elemental Ag nanoparticles to transform into AgCl as there was no evidence of AgCl formation in the presence of chloride alone. As a result, if Ag ions leach from consumer products, any chloride present may quickly scavenge the ions. In addition, the efficacy of Ag, as an antimicrobial agent in fabrics, may be limited, or even negated, after washing in solutions containing oxidizers as AgCl is much less reactive than Ag ion.
C1 [Impellitteri, Christopher A.; Tolaymat, Thabet M.; Scheckel, Kirk G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Tolaymat, TM (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM tolaymat.thabet@epa.gov
RI ID, MRCAT/G-7586-2011; Scheckel, Kirk/C-3082-2009
OI Scheckel, Kirk/0000-0001-9326-9241
NR 9
TC 69
Z9 71
U1 6
U2 45
PU AMER SOC AGRONOMY
PI MADISON
PA 677 S SEGOE RD, MADISON, WI 53711 USA
SN 0047-2425
J9 J ENVIRON QUAL
JI J. Environ. Qual.
PD JUL-AUG
PY 2009
VL 38
IS 4
BP 1528
EP 1530
DI 10.2134/jeq2008.0390
PG 3
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 467EG
UT WOS:000267719800020
PM 19465729
ER
PT J
AU Johnson, M
Hudgens, E
Williams, R
Andrews, G
Neas, L
Gallagher, J
Ozkaynak, H
AF Johnson, Markey
Hudgens, Edward
Williams, Ronald
Andrews, Gina
Neas, Lucas
Gallagher, Jane
Ozkaynak, Haluk
TI A participant-based approach to indoor/outdoor air monitoring in
community health studies
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE participant-based; air monitoring; air pollution; community health
ID NITROGEN-DIOXIDE; SOUTHERN CALIFORNIA; POLLUTION; CHILDREN; ASTHMA;
EXPOSURES; QUALITY; BIRTH; HOMES; POPULATION
AB Community health studies of traffic-related air pollution have been hampered by the cost and participant burden associated with collecting household-level exposure data. The current study utilized a participant-based approach to collect indoor and outdoor air monitoring data from 92 asthmatic and nonasthmatic children (9-13 years old) enrolled in two concurrent health studies in Detroit, Michigan (Mechanistic Indicators of Childhood Asthma and Detroit Children's Health Study) conducted by the US Environmental Protection Agency (EPA). Passive samplers were shipped to participating households and deployed by parents of study participants to collect indoor and outdoor measurements of nitrogen dioxide (NO(2)), volatile organic compounds (VOCs), and polycyclic aromatic hydrocarbons (PAHs) including naphthalene. Half of the households deployed VOC and NO(2) samplers for 7 days; the other half deployed PAH and NO(2) samplers for 2 days and additional PAH samplers for 1 day. Approximately 88% of the households that received air sampling kits completed the air monitoring. Compliance was significantly higher among participants asked to deploy all samplers for 7 days (85%) compared with participants asked to deploy some samplers for 2 days and others for 1 day (56%). The 7-day homes were also more likely to provide usable data (96%) compared with the 1- and 2-day homes (73%). Compliance and providing usable data did not vary between parents of asthmatic versus nonasthmatic study participants and were not reduced among households deploying duplicate samplers. These results suggest that participant-based sampling may be a feasible and cost-effective alternative to traditional exposure assessment approaches that can be applied in future epidemiological and community-based health studies. Journal of Exposure Science and Environmental Epidemiology (2009) 19, 492-501; doi: 10.1038/jes.2008.39; published online 9 July 2008
C1 [Johnson, Markey] US EPA, Human Studies Div MD 58A, Epidemiol & Biomarkers Branch, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Johnson, Markey; Williams, Ronald; Ozkaynak, Haluk] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Johnson, M (reprint author), US EPA, Human Studies Div MD 58A, Epidemiol & Biomarkers Branch, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM johnson.marym@epa.gov
RI Neas, Lucas/J-9378-2012
FU EPA/NERL machine shop
FX We are grateful to willingness and the diligent efforts of all of the
study participants who contributed tremendously to the success of this
project. We recognize and greatly appreciate the contributions to this
study by Dr. Zhihua Fan and Lin Lin at EOHSI with the preparation and
analysis of the passive PAH samplers; Dr. Mike Wolfson and Denise
Lamoureux at the Harvard School of Public Health with the preparation
and analysis of the NO2 badges; and Larissa Altshul, Brian La
Brecque and Jose Valero at the Harvard School of Public Health with the
preparation and analyses of the VOC diffusion tubes. We are deeply
indebted to James Quackenboss and Kent Thomas at EPA/NERL for their
detailed and insightful feedback on draft versions of this manuscript.
We also thank colleagues at EPA/NHEERL Pauline Mendola, Ann Williams,
Chris Garlington, Eliza-beth Sams, Kristen Rappazzo, Peter Stone, Kay
Williams, Scott Rhoney, Brooke Heidenfelder, Danelle Lobdell, Sharon
Myers, Jeff Inmon, Walter Breyer, as well as Daniel Vallero at EPA/NERL
and the EPA/NERL machine shop for their support and assistance during
this project.
NR 32
TC 6
Z9 6
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD JUL-AUG
PY 2009
VL 19
IS 5
BP 492
EP 501
DI 10.1038/jes.2008.39
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 468KX
UT WOS:000267818200004
PM 18612325
ER
PT J
AU Golden, NJ
Crouch, EA
Latimer, H
Kadry, AR
Kause, J
AF Golden, Neal J.
Crouch, Edmund A.
Latimer, Heejeong
Kadry, Abdel-Razak
Kause, Janell
TI Risk Assessment for Clostridium perfringens in Ready-to-Eat and
Partially Cooked Meat and Poultry Products
SO JOURNAL OF FOOD PROTECTION
LA English
DT Article
ID GROUND-BEEF; THERMAL INACTIVATION; SODIUM PYROPHOSPHATE; VEGETATIVE
CELLS; PREDICTIVE MODEL; UNITED-STATES; GROWTH; SPORES; SPICES;
TEMPERATURE
AB An assessment of the risk of illness associated with Clostridium perfringens in ready-to-eat and partially cooked meat and poultry products was completed to estimate the effect on the annual frequency of illnesses of changing the allowed maximal 1-log growth of C. perfringens during stabilization (cooling after the manufacturing heat step). The exposure assessment modeled stabilization, storage, and consumer preparation such as reheating and hot-holding. The model predicted that assuming a 10- or 100-fold increase from the assumed 1-log (maximal allowable) growth of C. perfringens results in a 1.2- or 1.6-fold increase of C. perfringens-caused illnesses, respectively, at the median of the uncertainty distribution. Improper retail and consumer refrigeration accounted for approximately 90% of the 79,000 C. perfringens illnesses predicted by the model at 1-log growth during stabilization. Improper hot-holding accounted for 8% of predicted illnesses, although model limitations imply that this is an underestimate. Stabilization accounted for less than 1% of illnesses. Efforts to reduce illnesses from C. perfringens in ready-to-eat and partially cooked meat and poultry products should focus on retail and consumer storage and preparation methods.
C1 [Golden, Neal J.; Latimer, Heejeong; Kause, Janell] US Food Safety & Inspect Serv, Risk Assessment Div, Off Publ Hlth Sci, USDA, Washington, DC 20250 USA.
[Crouch, Edmund A.] Cambridge Environm Inc, Cambridge, MA 02141 USA.
[Kadry, Abdel-Razak] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Golden, NJ (reprint author), US Food Safety & Inspect Serv, Risk Assessment Div, Off Publ Hlth Sci, USDA, Washington, DC 20250 USA.
EM neal.golden@fsis.usda.gov
NR 53
TC 17
Z9 17
U1 4
U2 14
PU INT ASSOC FOOD PROTECTION
PI DES MOINES
PA 6200 AURORA AVE SUITE 200W, DES MOINES, IA 50322-2863 USA
SN 0362-028X
J9 J FOOD PROTECT
JI J. Food Prot.
PD JUL
PY 2009
VL 72
IS 7
BP 1376
EP 1384
PG 9
WC Biotechnology & Applied Microbiology; Food Science & Technology
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 468JF
UT WOS:000267812800001
PM 19681258
ER
PT J
AU Shields, AR
Smith, WO
AF Shields, Amy R.
Smith, Walker O.
TI Size-fractionated photosynthesis/irradiance relationships during
Phaeocystis antarctica-dominated blooms in the Ross Sea, Antarctica
SO JOURNAL OF PLANKTON RESEARCH
LA English
DT Article
ID PHYTOPLANKTON ASSEMBLAGE COMPOSITION; SHELF WATERS; GLOBOSA
PRYMNESIOPHYCEAE; MARINE-PHYTOPLANKTON; COMMUNITY STRUCTURE; COASTAL
WATERS; GROWTH-RATES; CELL-SIZE; IRON; ABUNDANCE
AB In the Ross Sea, there are two major phytoplankton functional groups: diatoms and prymnesiophytes (dominated by Phaeocystis antarctica). Phaeocystis antarctica often occurs in colonial form, but also as solitary cells, and the two forms have distinct ecological roles. A comparison of the growth characteristics of solitary and colonial forms of Phaeocystis sp. is essential to understanding the differential impact each has on biogeochemical and ecological processes, and to allow parameterization of each form in numerical models. We measured the biomass and photosynthetic responses of two size fractions (> 20 and < 20 mu m), representing colonies and solitary cells, at locations dominated by P. antarctica to assess the relative photosynthetic potential of the two forms. While the relative contribution of each form to total P. antarctica biomass differed among years, there were no significant differences between maximum photosynthetic rates of colonial and solitary forms within years. Substantial interannual variations in biomass and maximum photosynthetic rates normalized to chlorophyll a (PmB) and initial light-limited rates of photosynthesis (alpha) were observed among years for the colonial fractions; however, interannual variations in maximum rates of photosynthesis or alpha of solitary cells were not observed. A laboratory experiment with P. antarctica, together with field data, showed that growth stage of colonies strongly affected the maximum photosynthetic rates. Under nutrient-replete conditions and exponential growth, colonial cells had higher maximum photosynthetic rates than solitary cells, but as growth rate declined and senescence began, the solitary cells' rates became greater. This may be a reason for the high abundance of colonies that is often found in the Ross Sea during austral spring. Our results suggest that photosynthetic rates may influence the composition of the morphotypes of Phaeocystis, but do not appear to be the sole factor in regulating this critical biological variable.
C1 [Shields, Amy R.; Smith, Walker O.] Coll William & Mary, Virginia Inst Marine Sci, Gloucester Point, VA 23062 USA.
RP Shields, AR (reprint author), US EPA, Water Wetlands & Pesticide Div, Reg 7,901N 5th St, Kansas City, KS 66101 USA.
EM shields.amy@epa.gov
FU NSF [OPP-0087401, 0440478]
FX This research was supported by NSF grants OPP-0087401 and 0440478 to
W.O.S.
NR 47
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Z9 10
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0142-7873
J9 J PLANKTON RES
JI J. Plankton Res.
PD JUL
PY 2009
VL 31
IS 7
BP 701
EP 712
DI 10.1093/plankt/fbp022
PG 12
WC Marine & Freshwater Biology; Oceanography
SC Marine & Freshwater Biology; Oceanography
GA 454PV
UT WOS:000266695700001
ER
PT J
AU Gordon, CJ
AF Gordon, Christopher J.
TI Quantifying the instability of core temperature in rodents
SO JOURNAL OF THERMAL BIOLOGY
LA English
DT Article
DE Telemetry; Temperature regulation; Temperature differential; Mouse; Rat;
Strain; Bedding; Ambient temperature
ID BODY-TEMPERATURE; RAT; RHYTHMS; MAMMALS
AB Radiotelemetry provides researchers with the ability to sample the core temperature of rodents and other species rapidly. Compared to large mammals, the time-course of core temperature of rodents is variable and their data are often averaged into bins of one or more hours for publication. When viewing averaged data, a stable core temperature over a wide range of ambient temperatures is observed; however, if the time-course of core temperature of individual animals is examined closely with a sampling period of 1-10 min, a continuous waxing and waning of temperature is observed. It is proposed that calculating the change in temperature from one time point to the next (i.e., temperature differential) is an informative measure of the performance of the thermoregulatory system. A quantitative measure of the stability of the thermoregulatory system can be determined by calculating the absolute value of the temperature differential. It is shown that the absolute temperature differential (ATD) is dependent on ambient temperature, genetic strain, type of cage bedding, and body size. The ATD is simple to calculate from telemetry data and may be an important parameter for the study of rodent thermal physiology. Published by Elsevier Ltd.
C1 US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Gordon, CJ (reprint author), US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM Gordon.christopher@epa.gov
NR 20
TC 13
Z9 13
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4565
J9 J THERM BIOL
JI J. Therm. Biol.
PD JUL
PY 2009
VL 34
IS 5
BP 213
EP 219
DI 10.1016/j.jtherbio.2009.02.002
PG 7
WC Biology; Zoology
SC Life Sciences & Biomedicine - Other Topics; Zoology
GA 462IV
UT WOS:000267345800001
ER
PT J
AU Friedman, SD
Cooper, EM
Casanova, L
Sobsey, MD
Genthner, FJ
AF Friedman, Stephanie D.
Cooper, Emilie M.
Casanova, Lisa
Sobsey, Mark D.
Genthner, Fred J.
TI A reverse transcription-PCR assay to distinguish the four genogroups of
male-specific (F plus ) RNA coliphages
SO JOURNAL OF VIROLOGICAL METHODS
LA English
DT Article
DE Male-specific RNA coliphage; FRNA; Fecal pollution; Genotyping
ID WATER SAMPLES; WASTE-WATER; PHAGES; BACTERIOPHAGES; HYBRIDIZATION
AB Goals of reducing fecal contamination in recreational, drinking, shellfishing and other waters and accurately assessing risk from exposure can best be attained if tools to distinguish between sources of pollution are available. The male-specific RNA coliphage (FRNA) genogroups display a trend of source specificity. Reverse transcription-PCR (RT-PCR) can be effectively used for genotyping if specific primer sets are designed to be capable of identifying all members within each genogroup. In this study genogroup-specific primer sets were designed using a minimum of 5 to a maximum of 10 complete phage genome sequences from strains in each genogroup. With these primers and employing a heat-release procedure that eliminated the need for RNA purification an RT-PCR method for genotype identification of FRNA phages was developed. The four genogroup-specific primer sets generated discrete PCR amplicon sizes from a variety of environmental FRNA phage strains. Limits of detection, cross-reactivity and/or non-specific binding to strains from other genogroups were evaluated. Published by Elsevier B.V.
C1 [Friedman, Stephanie D.; Cooper, Emilie M.; Genthner, Fred J.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
[Friedman, Stephanie D.; Casanova, Lisa; Sobsey, Mark D.] Univ N Carolina, Dept Environm Sci & Engn, Sch Publ Hlth, Chapel Hill, NC 27599 USA.
RP Friedman, SD (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM friedman.stephanie@epa.gov; cooper.emilie@epa.gov;
casanova@email.unc.edu; sobsey@email.unc.edu; genthner.fred@epa.gov
FU RARE; U.S. Environmental Protection Agency
FX The information in this document has been funded wholly (or in part) by
the U.S. Environmental Protection Agency. It has been subjected to
review by the National Health and Environmental Effects Research
Laboratory and approved for publication. Approval does not signify that
the contents reflect the views of the Agency, nor does mention of trade
names or commercial products constitute endorsement or recommendation
for use.
NR 30
TC 13
Z9 13
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-0934
J9 J VIROL METHODS
JI J. Virol. Methods
PD JUL
PY 2009
VL 159
IS 1
BP 47
EP 52
DI 10.1016/j.jviromet.2009.02.028
PG 6
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Virology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Virology
GA 454NB
UT WOS:000266687800009
PM 19442844
ER
PT J
AU Evans, O
Kauffman, P
Vonderheide, AR
Wymer, LJ
Morgan, JN
AF Evans, Otis
Kauffman, Peter
Vonderheide, Anne R.
Wymer, Larry J.
Morgan, Jeffrey N.
TI The determination of pesticidal and non-pesticidal organotin compounds
in water matrices by in situ ethylation and gas chromatography with
pulsed flame photometric detection
SO MICROCHEMICAL JOURNAL
LA English
DT Article
DE Pesticidal organotins; Non-pesticidal organotins; In situ ethylation;
Liquid-liquid extraction; GC-PFPD; Comproportionation
ID TANDEM MASS-SPECTROMETRY; LANDFILL LEACHATES; BUTYLTIN COMPOUNDS;
EXTRACTION; SPECIATION; SAMPLES; MICROEXTRACTION; OPTIMIZATION; SEDIMENT
AB The concurrent determination of pesticidal and non-pesticidal organotin compounds in several water matrices, using a simultaneous in situ ethylation and liquid-liquid extraction followed by splitless injection mode capillary gas chromatography with pulsed flame photometric detection, is described. The speciation analysis of nine organotin compounds includes low molecular weight-low boiling (non-pesticidal) and high molecular weight-high boiling analytes (pesticidal) of significant environmental interest. The minimum time for sodium tetraethylborate alkylation, using mechanical agitation, is determined to be 15 min in order to ensure the complete derivatization of the entire list of analytes. The utilization of a "hot needle" and a rapid injection rate is shown to be an efficacious means to eliminate "mass" or "needle" discrimination when determining the mixture of organotin compounds. Method detection limits are calculated to be in the low ng L(-1) range. The final method is applied to various water samples; storm water from the Cincinnati area demonstrated low native levels of three of the organotin compounds. Published by Elsevier B.V.
C1 [Kauffman, Peter; Morgan, Jeffrey N.] US EPA, Chem Exposure Res Branch, Microbiol & Chem Exposure Assessment Res Div, Natl Exposure Res Lab,Natl Council Aging, Cincinnati, OH 45268 USA.
RP Morgan, JN (reprint author), US EPA, Chem Exposure Res Branch, Microbiol & Chem Exposure Assessment Res Div, Natl Exposure Res Lab,Natl Council Aging, MS 564,26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM Morgan.jeffrey@epa.gov
NR 22
TC 5
Z9 6
U1 2
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0026-265X
J9 MICROCHEM J
JI Microchem J.
PD JUL
PY 2009
VL 92
IS 2
BP 155
EP 164
DI 10.1016/j.microc.2009.03.004
PG 10
WC Chemistry, Analytical
SC Chemistry
GA 460BS
UT WOS:000267160400008
ER
PT J
AU Eastmond, DA
Hartwig, A
Anderson, D
Anwar, WA
Cimino, MC
Dobrev, I
Douglas, GR
Nohmi, T
Phillips, DH
Vickers, C
AF Eastmond, David A.
Hartwig, Andrea
Anderson, Diana
Anwar, Wagida A.
Cimino, Michael C.
Dobrev, Ivan
Douglas, George R.
Nohmi, Takehiko
Phillips, David H.
Vickers, Carolyn
TI Mutagenicity testing for chemical risk assessment: update of the
WHO/IPCS Harmonized Scheme
SO MUTAGENESIS
LA English
DT Article
ID VITRO MICRONUCLEUS TEST; GENE MUTATION ASSAY; DISCRIMINATE RODENT
CARCINOGENS; TANDEM REPEAT INSTABILITY; IWGT WORKING GROUP; IN-VIVO
TESTS; COMET ASSAY; INTERNATIONAL WORKSHOP; GENOTOXICITY TESTS; RELATIVE
PREDICTIVITY
AB Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for mutagenicity. Safety assessments of substances with regard to genotoxicity are generally based on a combination of tests to assess effects on three major end points of genetic damage associated with human disease: gene mutation, clastogenicity and aneuploidy. It is now clear from the results of international collaborative studies and the large databases that are currently available for the assays evaluated that no single assay can detect all genotoxic substances. The World Health Organization therefore decided to update the IPCS Harmonized Scheme for Mutagenicity Testing as part of the IPCS project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. The approach presented in this paper focuses on the identification of mutagens and genotoxic carcinogens. Selection of appropriate in vitro and in vivo tests as well as a strategy for germ cell testing are described.
C1 [Vickers, Carolyn] WHO, Int Programme Chem Safety, CH-1211 Geneva, Switzerland.
[Eastmond, David A.] Univ Calif Riverside, Environm Toxicol Grad Program, Riverside, CA 92521 USA.
[Hartwig, Andrea] Tech Univ Berlin, Inst Lebensmitteltechnol & Lebensmittelchem, Berlin, Germany.
[Anderson, Diana] Univ Bradford, Dept Biomed Sci, Bradford BD7 1DP, W Yorkshire, England.
[Anwar, Wagida A.] Ain Shams Univ, Fac Med, Dept Community Environm & Occupat Med, Cairo, Egypt.
[Cimino, Michael C.] Environm Protect Agcy, Sci Support Branch, Risk Assessment Div, Off Pollut Prevent & Tox, Washington, DC USA.
[Dobrev, Ivan] Fraunhofer Inst Toxicol & Expt Med, Dept Chem Risk Assessment, Hannover, Germany.
[Douglas, George R.] Hlth Canada, Healthy Environm & Consumer Safety Branch, Mechanist Studies Div, Ottawa, ON K1A 0L2, Canada.
[Nohmi, Takehiko] Natl Inst Hlth Sci, Div Genet & Mutagenesis, Tokyo, Japan.
[Phillips, David H.] Inst Canc Res, Sect Mol Carcinogenesis, Sutton, Surrey, England.
RP Vickers, C (reprint author), WHO, Int Programme Chem Safety, CH-1211 Geneva, Switzerland.
EM ipcsmail@who.int
RI Anderson, Diana/J-6472-2015;
OI Anderson, Diana/0000-0001-9673-0398; Phillips, David/0000-0001-8509-3485
FU World Health Organization by
FX This work was funded by donations to the World Health Organization by a
number of member states of the World Health Assembly.
NR 67
TC 66
Z9 75
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0267-8357
J9 MUTAGENESIS
JI Mutagenesis
PD JUL
PY 2009
VL 24
IS 4
BP 341
EP 349
DI 10.1093/mutage/gep014
PG 9
WC Genetics & Heredity; Toxicology
SC Genetics & Heredity; Toxicology
GA 463OO
UT WOS:000267441700007
PM 19535363
ER
PT J
AU Dobrovolskaia, MA
Germolec, DR
Weaver, JL
AF Dobrovolskaia, Marina A.
Germolec, Dori R.
Weaver, James L.
TI Evaluation of nanoparticle immunotoxicity
SO NATURE NANOTECHNOLOGY
LA English
DT Review
ID VACCINES; ISSUES; SIZE
AB The pharmaceutical industry is developing increasing numbers of drugs and diagnostics based on nanoparticles, and evaluating the immune response to these diverse formulations has become a challenge for scientists and regulatory agencies alike. An international panel of scientists and representatives from various agencies and companies reviewed the limitations of current tests at a workshop held at the National Cancer Institute in Frederick, Maryland. This article outlines practical strategies for identifying and controlling interferences in common evaluation methods and the implications for regulation.
C1 [Dobrovolskaia, Marina A.] NCI, SAIC Frederick Inc, Nanotechnol Characterizat Lab, Frederick, MD 21702 USA.
[Germolec, Dori R.] Natl Inst Environm Hlth Sci, Toxicol Branch, Natl Toxicol Program, NIH,DHHS, Res Triangle Pk, NC 27709 USA.
[Weaver, James L.] US FDA, CDER, Div Appl Pharmacol Res, Silver Spring, MD 20993 USA.
RP Dobrovolskaia, MA (reprint author), NCI, SAIC Frederick Inc, Nanotechnol Characterizat Lab, Frederick, MD 21702 USA.
EM marina@mail.nih.gov
RI Nanotechnology Characterization Lab, NCL/K-8454-2012
FU PHS HHS [HHSN261200800001E]
NR 12
TC 157
Z9 158
U1 3
U2 73
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1748-3387
J9 NAT NANOTECHNOL
JI Nat. Nanotechnol.
PD JUL
PY 2009
VL 4
IS 7
BP 411
EP 414
DI 10.1038/NNANO.2009.175
PG 4
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA 478OJ
UT WOS:000268597300009
PM 19581891
ER
PT J
AU Bushnell, P
AF Bushnell, Philip
TI Behavioral toxicology in the 21st century: Challenges and opportunities
for behavioral scientists
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Meeting Abstract
CT 33rd Annual Meeting of the Neurobehavioral-Teratology-Society/49th
Annual Meeting of the Teratology-Society/22nd Annual Meeting of the
Organization-of-Teratology-Information-Specialists
CY JUN 28-JUL 01, 2009
CL Rio Grande, PR
SP Neurobehav Teratol Soc, Teratol Soc, Org Teratol Informat Specialists
C1 [Bushnell, Philip] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JUL-SEP
PY 2009
VL 31
IS 4
MA NBTS2
BP 237
EP 237
DI 10.1016/j.ntt.2009.04.006
PG 1
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA 461GY
UT WOS:000267253900009
ER
PT J
AU Crofton, K
AF Crofton, Kevin
TI Developmental neurotoxicity and thyroid hormone disruptors: Past,
present and future
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Meeting Abstract
CT 33rd Annual Meeting of the Neurobehavioral-Teratology-Society/49th
Annual Meeting of the Teratology-Society/22nd Annual Meeting of the
Organization-of-Teratology-Information-Specialists
CY JUN 28-JUL 01, 2009
CL Rio Grande, PR
SP Neurobehav Teratol Soc, Teratol Soc, Org Teratol Informat Specialists
C1 [Crofton, Kevin] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JUL-SEP
PY 2009
VL 31
IS 4
MA NBTS4
BP 237
EP 238
DI 10.1016/j.ntt.2009.04.008
PG 2
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA 461GY
UT WOS:000267253900011
ER
PT J
AU Kavlock, R
AF Kavlock, Robert
TI The future of toxicity testing-The NRC vision and the EPA's ToxCast
program national center for computational toxicology
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Meeting Abstract
CT 33rd Annual Meeting of the Neurobehavioral-Teratology-Society/49th
Annual Meeting of the Teratology-Society/22nd Annual Meeting of the
Organization-of-Teratology-Information-Specialists
CY JUN 28-JUL 01, 2009
CL Rio Grande, PR
SP Neurobehav Teratol Soc, Teratol Soc, Org Teratol Informat Specialists
C1 [Kavlock, Robert] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 8
Z9 8
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JUL-SEP
PY 2009
VL 31
IS 4
MA NBTS3
BP 237
EP 237
DI 10.1016/j.ntt.2009.04.007
PG 1
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA 461GY
UT WOS:000267253900010
ER
PT J
AU Moser, G
AF Moser, Ginger
TI The behavioral toxicology society-Past, present and future
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Meeting Abstract
CT 33rd Annual Meeting of the Neurobehavioral-Teratology-Society/49th
Annual Meeting of the Teratology-Society/22nd Annual Meeting of the
Organization-of-Teratology-Information-Specialists
CY JUN 28-JUL 01, 2009
CL Rio Grande, PR
SP Neurobehav Teratol Soc, Teratol Soc, Org Teratol Informat Specialists
C1 [Moser, Ginger] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JUL-SEP
PY 2009
VL 31
IS 4
MA NBTS1
BP 237
EP 237
DI 10.1016/j.ntt.2009.04.005
PG 1
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA 461GY
UT WOS:000267253900008
ER
PT J
AU Bushnell, P
AF Bushnell, Philip
TI An acute toxicity pathway based on ion channel perturbation
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Meeting Abstract
CT 33rd Annual Meeting of the Neurobehavioral-Teratology-Society/49th
Annual Meeting of the Teratology-Society/22nd Annual Meeting of the
Organization-of-Teratology-Information-Specialists
CY JUN 28-JUL 01, 2009
CL Rio Grande, PR
SP Neurobehav Teratol Soc, Teratol Soc, Org Teratol Informat Specialists
C1 [Bushnell, Philip] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JUL-SEP
PY 2009
VL 31
IS 4
MA NBTS5
BP 238
EP 238
DI 10.1016/j.ntt.2009.04.009
PG 1
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA 461GY
UT WOS:000267253900012
ER
PT J
AU Barone, S
AF Barone, Stan, Jr.
TI Overview of environmental vulnerability to chemical exposures
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Meeting Abstract
CT 33rd Annual Meeting of the Neurobehavioral-Teratology-Society/49th
Annual Meeting of the Teratology-Society/22nd Annual Meeting of the
Organization-of-Teratology-Information-Specialists
CY JUN 28-JUL 01, 2009
CL Rio Grande, PR
SP Neurobehav Teratol Soc, Teratol Soc, Org Teratol Informat Specialists
C1 [Barone, Stan, Jr.] US EPA, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JUL-SEP
PY 2009
VL 31
IS 4
MA NBTS13
BP 240
EP 240
DI 10.1016/j.ntt.2009.04.017
PG 1
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA 461GY
UT WOS:000267253900020
ER
PT J
AU Gohlke, JM
Stockton, P
Sieber, S
Foley, J
Portier, CJ
AF Gohlke, J. M.
Stockton, P.
Sieber, S.
Foley, J.
Portier, C. J.
TI AhR-mediated gene expression in the developing mouse telencephalon
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Meeting Abstract
CT 33rd Annual Meeting of the Neurobehavioral-Teratology-Society/49th
Annual Meeting of the Teratology-Society/22nd Annual Meeting of the
Organization-of-Teratology-Information-Specialists
CY JUN 28-JUL 01, 2009
CL Rio Grande, PR
SP Neurobehav Teratol Soc, Teratol Soc, Org Teratol Informat Specialists
C1 [Gohlke, J. M.; Portier, C. J.] Natl Inst Environm Hlth Sci, Environm Syst Biol Grp, Mol Toxicol Lab, Res Triangle Pk, NC USA.
[Stockton, P.; Foley, J.] Natl Inst Environm Hlth Sci, Lab Environm Pathol, Res Triangle Pk, NC USA.
[Sieber, S.] Natl Inst Environm Hlth Sci, Microarray Grp, Mol Toxicol Lab, Res Triangle Pk, NC USA.
RI Portier, Christopher/A-3160-2010
OI Portier, Christopher/0000-0002-0954-0279
NR 0
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JUL-SEP
PY 2009
VL 31
IS 4
MA NBTS17
BP 241
EP 241
DI 10.1016/j.ntt.2009.04.021
PG 1
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA 461GY
UT WOS:000267253900024
ER
PT J
AU Knudsen, TB
Martin, MT
Kavlock, RJ
Judson, RS
Dix, DJ
Singh, AV
AF Knudsen, T. B.
Martin, M. T.
Kavlock, R. J.
Judson, R. S.
Dix, D. J.
Singh, A. V.
TI Profiling developmental toxicity of 387 environmental chemicals using
EPA's Toxicity Reference Database (ToxRefDB)
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Meeting Abstract
CT 33rd Annual Meeting of the Neurobehavioral-Teratology-Society/49th
Annual Meeting of the Teratology-Society/22nd Annual Meeting of the
Organization-of-Teratology-Information-Specialists
CY JUN 28-JUL 01, 2009
CL Rio Grande, PR
SP Neurobehav Teratol Soc, Teratol Soc, Org Teratol Informat Specialists
C1 [Knudsen, T. B.; Martin, M. T.; Kavlock, R. J.; Judson, R. S.; Dix, D. J.] US EPA, NCCT, Res Triangle Pk, NC USA.
[Singh, A. V.] Lockheed Martin, Res Triangle Pk, NC USA.
RI Singh, Amar/K-4400-2013
OI Singh, Amar/0000-0003-3780-8233
NR 0
TC 0
Z9 0
U1 2
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JUL-SEP
PY 2009
VL 31
IS 4
MA NBTS19
BP 241
EP 241
DI 10.1016/j.ntt.2009.04.023
PG 1
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA 461GY
UT WOS:000267253900026
ER
PT J
AU Gilbert, M
MacPhail, R
Baldwon, J
Moser, VC
Chernoff, N
AF Gilbert, Mary
MacPhail, Robert
Baldwon, J.
Moser, V. C.
Chernoff, N.
TI Undernutrition in early life does not impair learning in young or aged
animals
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Meeting Abstract
CT 33rd Annual Meeting of the Neurobehavioral-Teratology-Society/49th
Annual Meeting of the Teratology-Society/22nd Annual Meeting of the
Organization-of-Teratology-Information-Specialists
CY JUN 28-JUL 01, 2009
CL Rio Grande, PR
SP Neurobehav Teratol Soc, Teratol Soc, Org Teratol Informat Specialists
C1 [Gilbert, Mary; MacPhail, Robert; Baldwon, J.; Moser, V. C.; Chernoff, N.] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JUL-SEP
PY 2009
VL 31
IS 4
MA NBTS30
BP 244
EP 244
DI 10.1016/j.ntt.2009.04.034
PG 1
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA 461GY
UT WOS:000267253900037
ER
PT J
AU Raffaele, K
Rowland, J
May, B
Makris, S
Schumacher, K
Scarano, L
AF Raffaele, Kathleen
Rowland, Jess
May, Brenda
Makris, Susan
Schumacher, Kelly
Scarano, Louis
TI The use of developmental neurotoxicity data in pesticide risk
assessments
SO NEUROTOXICOLOGY AND TERATOLOGY
LA English
DT Meeting Abstract
CT 33rd Annual Meeting of the Neurobehavioral-Teratology-Society/49th
Annual Meeting of the Teratology-Society/22nd Annual Meeting of the
Organization-of-Teratology-Information-Specialists
CY JUN 28-JUL 01, 2009
CL Rio Grande, PR
SP Neurobehav Teratol Soc, Teratol Soc, Org Teratol Informat Specialists
C1 [Raffaele, Kathleen; Makris, Susan] US EPA, Off Res & Dev, Washington, DC 20460 USA.
[Rowland, Jess; May, Brenda] US EPA, Off Pesticide Programs, Washington, DC 20460 USA.
[Scarano, Louis] US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA.
[Schumacher, Kelly] US EPA, Kansas City, KS USA.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0892-0362
J9 NEUROTOXICOL TERATOL
JI Neurotoxicol. Teratol.
PD JUL-SEP
PY 2009
VL 31
IS 4
MA NBTS52
BP 250
EP 250
DI 10.1016/j.ntt.2009.04.056
PG 1
WC Neurosciences; Toxicology
SC Neurosciences & Neurology; Toxicology
GA 461GY
UT WOS:000267253900059
ER
PT J
AU Xu, ZL
Taylor, JA
AF Xu, Zongli
Taylor, Jack A.
TI SNPinfo: integrating GWAS and candidate gene information into functional
SNP selection for genetic association studies
SO NUCLEIC ACIDS RESEARCH
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; EXONIC SPLICING ENHANCERS; FACTOR-BINDING
SITES; PROSTATE-CANCER; SEQUENCES; SINGLE; DNA
AB We have developed a set of web-based SNP selection tools (freely available at http://www.niehs.nih.gov/snpinfo) where investigators can specify genes or linkage regions and select SNPs based on GWAS results, linkage disequilibrium (LD), and predicted functional characteristics of both coding and non-coding SNPs. The algorithm uses GWAS SNP P-value data and finds all SNPs in high LD with GWAS SNPs, so that selection is from a much larger set of SNPs than the GWAS itself. The program can also identify and choose tag SNPs for SNPs not in high LD with any GWAS SNP. We incorporate functional predictions of protein structure, gene regulation, splicing and miRNA binding, and consider whether the alternative alleles of a SNP are likely to have differential effects on function. Users can assign weights for different functional categories of SNPs to further tailor SNP selection. The program accounts for LD structure of different populations so that a GWAS study from one ethnic group can be used to choose SNPs for one or more other ethnic groups. Finally, we provide an example using prostate cancer and demonstrate that this algorithm can select a small panel of SNPs that include many of the recently validated prostate cancer SNPs.
C1 [Xu, Zongli; Taylor, Jack A.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
[Taylor, Jack A.] Natl Inst Environm Hlth Sci, Mol Carcinogenesis Lab, Res Triangle Pk, NC 27709 USA.
RP Taylor, JA (reprint author), Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
EM xuz@niehs.nih.gov; taylor@niehs.nih.gov
OI xu, zongli/0000-0002-9034-8902; taylor, jack/0000-0001-5303-6398
FU NIH
FX This research was supported by the Intramural Research Program of the
NIH, National Institute of Environmental Health Sciences. Funding for
open access charge: National Institute of Environmental Health Sciences.
NR 26
TC 265
Z9 274
U1 5
U2 22
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0305-1048
J9 NUCLEIC ACIDS RES
JI Nucleic Acids Res.
PD JUL 1
PY 2009
VL 37
BP W600
EP W605
DI 10.1093/nar/gkp290
PG 6
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 469IG
UT WOS:000267889100104
PM 19417063
ER
PT J
AU Phillips, DL
Johnson, MG
Tingey, DT
Storm, MJ
AF Phillips, Donald L.
Johnson, Mark G.
Tingey, David T.
Storm, Marjorie J.
TI Elevated CO2 and O-3 effects on fine-root survivorship in ponderosa pine
mesocosms
SO OECOLOGIA
LA English
DT Article
DE Fine root life span; Mortality; Turnover; Survival analysis;
Proportional hazards
ID ATMOSPHERIC CARBON-DIOXIDE; 3 GROWING SEASONS; SOIL RESPIRATION;
TROPOSPHERIC O-3; SILVER BIRCH; LIFE-SPAN; DECIDUOUS FOREST; NORTHERN
FORESTS; GROWTH-RESPONSES; N-FERTILIZATION
AB Atmospheric carbon dioxide (CO2) and ozone (O-3) concentrations are rising, which may have opposing effects on tree C balance and allocation to fine roots. More information is needed on interactive CO2 and O-3 effects on roots, particularly fine-root life span, a critical demographic parameter and determinant of soil C and N pools and cycling rates. We conducted a study in which ponderosa pine (Pinus ponderosa) seedlings were exposed to two levels of CO2 and O-3 in sun-lit controlled-environment mesocosms for 3 years. Minirhizotrons were used to monitor individual fine roots in three soil horizons every 28 days. Proportional hazards regression was used to analyze effects of CO2, O-3, diameter, depth, and season of root initiation on fine-root survivorship. More fine roots were produced in the elevated CO2 treatment than in ambient CO2. Elevated CO2, increasing root diameter, and increasing root depth all significantly increased fine-root survivorship and median life span. Life span was slightly, but not significantly, lower in elevated O-3, and increased O-3 did not reduce the effect of elevated CO2. Median life spans varied from 140 to 448 days depending on the season of root initiation. These results indicate the potential for elevated CO2 to increase the number of fine roots and their residence time in the soil, which is also affected by root diameter, root depth, and phenology.
C1 [Phillips, Donald L.; Johnson, Mark G.; Tingey, David T.] US EPA, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
[Storm, Marjorie J.] US EPA, Dynamac Int Inc, Corvallis, OR 97333 USA.
RP Phillips, DL (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, 200 SW 35th St, Corvallis, OR 97333 USA.
EM phillips.donald@epa.gov
RI Phillips, Donald/D-5270-2011
FU US Environmental Protection Agency (EPA); US Dept. of Energy
[(DE-AI0396ER62288]; EPA [RW89937719, 68-C6-0005]; Dynamac Corporation
FX The information in this document has been funded by the US Environmental
Protection Agency (EPA), and by an interagency agreement between the US
Dept. of Energy (DE-AI0396ER62288) and EPA (RW89937719). Part of the
work was conducted under contract 68-C6-0005 between EPA and Dynamac
Corporation.
NR 72
TC 6
Z9 9
U1 2
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0029-8549
J9 OECOLOGIA
JI Oecologia
PD JUL
PY 2009
VL 160
IS 4
BP 827
EP 837
DI 10.1007/s00442-009-1339-4
PG 11
WC Ecology
SC Environmental Sciences & Ecology
GA 460DA
UT WOS:000267165500019
PM 19415339
ER
PT J
AU Hryhorczuk, D
Dardynskaia, I
Lukyanova, E
Matwyshyn-Fuoco, M
Friedman, L
Shkiryak-Nizhnyk, Z
Zvinchuk, A
Chislovska, N
Antipkin, Y
AF Hryhorczuk, Daniel
Dardynskaia, Irina
Lukyanova, Elena
Matwyshyn-Fuoco, Marta
Friedman, Lee
Shkiryak-Nizhnyk, Zoreslava
Zvinchuk, Alexander
Chislovska, Natalia
Antipkin, Yuri
TI Risk factors for wheezing in Ukrainian children: Ukraine European
Longitudinal Study of Pregnancy and Childhood Group
SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
LA English
DT Article
DE wheezing; asthma; childhood; ELSPAC; housing; damp; heating; pets
contact with children
ID ASTHMA; PREVALENCE; EXPOSURE; ISAAC; ASSOCIATION; ALLERGIES; SYMPTOMS;
LEAD
AB The prevalence of wheezing in children varies widely around the world. The reasons for this geographic variability remain unclear but may be related in part to exposures in the home environment during pregnancy and early childhood. We investigated the prenatal and early childhood risk factors for wheezing symptoms among 2127 children aged 6-8 years who were participants in the Ukrainian component of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC). Cases included the 169 children whose parents answered yes to the International Study of Asthma and Allergy in Children (ISAAC) question: 'Has your child had wheezing or whistling in the chest in the past 12 months' during the ELSPAC assessment of the children at age 7. These were compared with the 1861 children in the cohort whose parents answered 'no' to this question.
Factors significantly associated with increased risk of wheezing illness at age 7 in adjusted analyses included mother's asthma [adjusted odds ratio (OR) 3.46, 95% confidence interval (CI) 1.22, 9.85]; mother's allergy problems (OR 1.43, [1.00, 2.05]); rarely playing with other children at age 3 (OR 1.84, [1.09, 3.11]); water intrusion (OR 1.62, [1.09, 2.39]) and inadequate heating of the home (OR 1.52, [1.06, 2.16]) during pregnancy. Factors protective of wheezing at age 7 included being first-born (adjusted OR 0.70, 95% CI 0.50, 0.98); living in the city of Dniprodzerzynsk as compared with Kyiv (OR 0.36, [0.24, 0.54]) and weekly contact with furry animals (OR 0.44, [0.20, 0.97]) before age 3. The constellation of risk factors for wheezing in Ukrainian children is similar to that of children in other parts of the world. Known risk factors do not account for the significant between-city variability of wheezing in Ukrainian children.
C1 [Hryhorczuk, Daniel; Dardynskaia, Irina] Univ Illinois, Great Lakes Ctr Occupat & Environm Safety & Hlth, Sch Publ Hlth, Chicago, IL 60612 USA.
[Hryhorczuk, Daniel; Dardynskaia, Irina; Friedman, Lee] Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL 60612 USA.
[Matwyshyn-Fuoco, Marta] US EPA, Chicago, IL USA.
[Zvinchuk, Alexander] Univ Illinois, Louise Hamilton Data Management Ctr, Kiev, Ukraine.
RP Hryhorczuk, D (reprint author), Univ Illinois, Great Lakes Ctr Occupat & Environm Safety & Hlth, Sch Publ Hlth, 2121 W Taylor, Chicago, IL 60612 USA.
EM dhryhorc@uic.edu
RI Friedman, Lee/G-9799-2011;
OI Zvinchuk, Alexander/0000-0001-7163-1932
FU NIH Research [D43 TW00653]; 'International Training and Research in
Environmental and Occupational Health'; Fogarty International Center
FX This project was supported by NIH Research Grant #D43 TW00653,
'International Training and Research in Environmental and Occupational
Health', awarded to the University of Illinois at Chicago by the Fogarty
International Center.
NR 24
TC 4
Z9 4
U1 2
U2 9
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0269-5022
J9 PAEDIATR PERINAT EP
JI Paediatr. Perinat. Epidemiol.
PD JUL
PY 2009
VL 23
IS 4
BP 346
EP 351
DI 10.1111/j.1365-3016.2009.01026.x
PG 6
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
Pediatrics
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
Pediatrics
GA 453HO
UT WOS:000266601700007
PM 19523081
ER
PT J
AU Haberg, SE
Stigum, H
London, SJ
Nystad, W
Nafstad, P
AF Haberg, Siri E.
Stigum, Hein
London, Stephanie J.
Nystad, Wenche
Nafstad, Per
TI Maternal obesity in pregnancy and respiratory health in early childhood
SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
LA English
DT Article
DE maternal obesity; maternal body mass index; infant respiratory
infection; infant wheezing; MoBa
ID BODY-MASS INDEX; 10-YEAR FOLLOW-UP; UNITED-STATES; ATOPIC DISEASE; BIRTH
COHORT; ASTHMA; CHILDREN; PREVALENCE; OVERWEIGHT; RISK
AB Obesity is associated with systemic inflammation, immunological changes, increased risk of respiratory infections and chronic respiratory illness. Maternal obesity in pregnancy increases the risk of pregnancy complications, caesarean sections and adverse birth outcomes, which have in turn been associated with respiratory illness in children. To our knowledge, the possible influence of maternal obesity in pregnancy on respiratory illness in early childhood beyond the newborn period has not been explored. We examined the relationship between a high maternal body mass index (BMI) in pregnancy and lower respiratory tract infections and wheeze up to 18 months of age in the Norwegian Mother and Child Study (MoBa), a population-based cohort study that includes 100 000 pregnant women, conducted at the Norwegian Institute of Public Health. We analysed data from the first 33 192 children, born between 1999 and 2005.
In unadjusted analyses maternal obesity in pregnancy was related to both respiratory infections and wheeze in the children. In multivariable analyses, only an effect on wheeze remained. The risk of wheeze increased linearly with maternal BMI in pregnancy, and was 3.3% higher [95% CI 1.2, 5.3] for children with mothers who were obese during pregnancy, than for children of mothers with normal BMI. This effect was not mediated through obesity-related pregnancy complications, low birthweight, preterm birth or caesarean section.
C1 [Haberg, Siri E.; Stigum, Hein; Nystad, Wenche; Nafstad, Per] Norwegian Inst Publ Hlth, Div Epidemiol, NO-0403 Oslo, Norway.
[Nafstad, Per] Univ Oslo, Dept Gen Practice & Community Med, Fac Med, Oslo, Norway.
[London, Stephanie J.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Durham, NC USA.
[London, Stephanie J.] Natl Inst Environm Hlth Sci, Lab Resp Biol, NIH, Dept Hlth & Human Serv, Durham, NC USA.
RP Haberg, SE (reprint author), Norwegian Inst Publ Hlth, Div Epidemiol, POB 4404 Nydalen, NO-0403 Oslo, Norway.
EM siri.haberg@fhi.no
OI London, Stephanie/0000-0003-4911-5290
FU Norwegian Foundation for Health and Rehabilitation; Division of
Intramural Research; National Institute of Environmental Health
Sciences; National Institutes of Health, USA [HHSN291200775558C,
Z01-ES-85433, 1 UO1 NS 047537-01]; Norwegian Ministry of Health;
Norwegian Research Council/FUGE [151918/S10]
FX We gratefully acknowledge the participation of the MoBa parents. The
Norwegian Mother and Child Cohort Study is supported by the Norwegian
Ministry of Health, Division of Intramural Research, National Institute
of Environmental Health Sciences, National Institutes of Health, USA
(Contract no. HHSN291200775558C and Project no. Z01-ES-85433), NIH/NINDS
(grant no. 1 UO1 NS 047537-01) and the Norwegian Research Council/FUGE
(grant no. 151918/S10).
NR 64
TC 39
Z9 40
U1 0
U2 6
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0269-5022
J9 PAEDIATR PERINAT EP
JI Paediatr. Perinat. Epidemiol.
PD JUL
PY 2009
VL 23
IS 4
BP 352
EP 362
DI 10.1111/j.1365-3016.2009.01034.x
PG 11
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
Pediatrics
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
Pediatrics
GA 453HO
UT WOS:000266601700008
PM 19523082
ER
PT J
AU Davis, A
Gift, JS
Woodall, GM
Narotsky, MG
Foureman, GL
AF Davis, Allen
Gift, Jeff S.
Woodall, George M.
Narotsky, Michael G.
Foureman, Gary L.
TI The role of developmental toxicity studies in acute exposure
assessments: Analysis of single-day vs. multiple-day exposure regimens
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Developmental toxicity; Butylbenzyl phthalate; Tributyltin; Benchmark
dose; Risk assessment; Acute exposure; Single-day; Multiple-day
ID BUTYL BENZYL PHTHALATE; TRIBUTYLTIN CHLORIDE; RATS; ENVIRONMENT;
TERATOLOGY; SEDIMENT; ESTERS
AB In accordance with most toxicity guidelines, developmental studies typically utilize repeated exposures, usually throughout gestation or during organogenesis in particular. However, it is known that developmental toxicity may occur in response to single exposures, especially during specific windows of susceptibility. An overview of the available literature gave sufficient evidence that for many agents, the same endpoints observed in repeated dose, multiple-day studies were also observed in single-day exposures, thus indicating the relevance of developmental toxicity to health assessments of acute exposures. Further, results of benchmark dose modeling of developmental endpoints indicated that for embryo lethality, single-day exposures required a two- to fourfold higher dose than the multiple-day exposures to produce the same level of response. For fused sternebrae, exposures on specific days produced equivalent levels of response at doses that were more similar to those utilized in the repeated exposures. Appreciable differences in biological half-life (and corresponding dose metrics) as well as specific windows of susceptibility may partially explain the observed multiple- vs. single-day exposure dose-response relationships. Our results highlight the need of a more thorough evaluation of outcomes from repeated dose developmental toxicity studies in regards to their importance to chronic and acute risk assessments. Published by Elsevier Inc.
C1 [Davis, Allen; Gift, Jeff S.; Woodall, George M.; Foureman, Gary L.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
[Davis, Allen] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC 27711 USA.
[Narotsky, Michael G.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Davis, A (reprint author), US EPA, Natl Ctr Environm Assessment, 109 TW Alexander Dr,Mail Code B243-01, Res Triangle Pk, NC 27711 USA.
EM davis.allen@epa.gov
RI Woodall, George/M-5658-2014
FU NCEA-CRISE Interagency Agreement; U.S. Environmental Protection Agency
FX Partial funding was provided by the NCEA-CRISE Interagency Agreement.
The information in this document has been subjected to review by the
National Center for Environmental Assessment, U.S. Environmental
Protection Agency, and approved for publication. Approval does not
signify that the contents reflect the views of the Agency, nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use. The research presented in this document was
funded in part by the U.S. Environmental Protection Agency.
NR 27
TC 3
Z9 3
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD JUL
PY 2009
VL 54
IS 2
BP 134
EP 142
DI 10.1016/j.yrtph.2009.03.006
PG 9
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA 457NW
UT WOS:000266939500005
PM 19306903
ER
PT J
AU Yuan, YP
Locke, MA
Gaston, LA
AF Yuan, Yongping
Locke, Martin A.
Gaston, Lewis A.
TI Tillage Effects on Soil Properties and Spatial Variability in Two
Mississippi Delta Watersheds
SO SOIL SCIENCE
LA English
DT Article
DE Tillage; nutrients; phosphorus; nitrogen
ID LONG-TERM TILLAGE; SOLUBLE PHOSPHORUS; CONSERVATION TILLAGE;
PHYSICAL-PROPERTIES; RUNOFF PHOSPHORUS; NITROGEN STORAGE;
ORGANIC-CARBON; LOSSES; MANAGEMENT; MEHLICH-3
AB This study evaluated changes in soil properties several years after implementation of conservation measures. Two approximately 50-ha fields within two Mississippi Delta oxbow lake watersheds (Deep Hollow and Beasley) were laid out in 60-m grids. Soil from a tilled cotton field in Deep Hollow watershed was sampled at each node in 1996 and again in 2000 after 4 years of reduced tillage cotton (Gossypium hirsutum) and winter wheat (Triticum aestivum L.) cover crops; soil also was collected from conventional tillage cotton in Beasley Lake watershed in 1996 and again in 2006 from the same grid nodes after 4 years of reduced tillage cotton and 5 years of reduced tillage soybeans. Organic matter levels in the soil surface were higher in both watersheds after conservation tillage was implemented, likely caused by increased plant residue accumulation and limited soil mixing. Higher soil P levels in both watersheds under conservation management were attributed to less distribution in soil because of reduced tillage, Lower NO3-N in Deep Hollow in 2000 suggested N immobilization in the soil surface. Nitrogen was not analyzed for Beasley soil samples. Soil pH values were also higher in the later samplings for both watersheds, but because lime was applied in the interim, it is difficult to ascribe an effect from tillage. Potassium, calcium, and magnesium were higher in 2000 after the 4-year reduced tillage practice in the Deep Hollow watershed. However, potassium, calcium, and magnesium were lower in 2006 than in 1996 at the Beasley Lake watershed because no fertilizer was applied to the field since 2001. Regardless of tillage system, relatively high P levels in soils from both watersheds are indicative of high native soil P levels in the Mississippi Delta soils. Similar to other studies, water-soluble P was positively correlated with Mehlich III P. Spatial relationships of P examined using kriging showed that P data were spatially dependent, and their spatial dependence was impacted by tillage practices.
C1 [Yuan, Yongping] US EPA, ORD, NERL, ESD,Landscape Ecol Branch, Las Vegas, NV 89193 USA.
[Locke, Martin A.] USDA ARS, Natl Sedimentat Lab, Water Qual & Ecol Res Unit, Oxford, MS 38655 USA.
[Gaston, Lewis A.] LSU AgCtr, Dept Agron & Environm Management, Baton Rouge, LA USA.
RP Yuan, YP (reprint author), US EPA, ORD, NERL, ESD,Landscape Ecol Branch, Las Vegas, NV 89193 USA.
EM yuan.yongping@epa.gov
NR 61
TC 3
Z9 3
U1 2
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0038-075X
EI 1538-9243
J9 SOIL SCI
JI Soil Sci.
PD JUL
PY 2009
VL 174
IS 7
BP 385
EP 394
DI 10.1097/SS.0b013e3181ac679c
PG 10
WC Soil Science
SC Agriculture
GA 470VG
UT WOS:000268008800004
ER
PT J
AU Chen, CW
AF Chen, Chao W.
TI Estimating birth and death rates from cell labeling data
SO STOCHASTIC ENVIRONMENTAL RESEARCH AND RISK ASSESSMENT
LA English
DT Article
DE Labeling index; Cell proliferation rate; Cell death rate; State space
model
ID BIOLOGICAL MODELS; CARCINOGENESIS; INDEXES
AB The objective of this article is to provide a statistical method for estimating both birth and death rates from labeling data. Current practice of estimating cell division (birth) rate alpha by the formula LI(t) = 1 - exp(-2 alpha t) suggests that the use of labeling index (LI) as a cell proliferation indicator may incur loss of valuable information inherited in the data that are used to calculate the index. Information about cell death has become increasingly important for understanding a disease processes, and for developing a biologically based dose-response model for environmental health risk assessments. Simple stochastic and deterministic models are proposed for estimating both birth and death rates simultaneously from labeling data.
C1 US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Chen, CW (reprint author), US EPA, Natl Ctr Environm Assessment, 1200 Penn Ave NW, Washington, DC 20460 USA.
EM chen.chao@epa.gov
NR 19
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1436-3240
J9 STOCH ENV RES RISK A
JI Stoch. Environ. Res. Risk Assess.
PD JUL
PY 2009
VL 23
IS 5
BP 621
EP 626
DI 10.1007/s00477-008-0247-1
PG 6
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences;
Statistics & Probability; Water Resources
SC Engineering; Environmental Sciences & Ecology; Mathematics; Water
Resources
GA 450IR
UT WOS:000266394700008
ER
PT J
AU Selgrade, MK
Bowman, CC
Ladics, GS
Privalle, L
Laessig, SA
AF Selgrade, MaryJane K.
Bowman, Christal C.
Ladics, Gregory S.
Privalle, Laura
Laessig, Susan A.
TI Safety Assessment of Biotechnology Products for Potential Risk of Food
Allergy: Implications of New Research
SO TOXICOLOGICAL SCIENCES
LA English
DT Editorial Material
DE Food Allergy; biotechnology; genetically modified crops; plant
incorporated pesticides; safety assessment
ID INTER-LABORATORY COMPARISONS; GENETICALLY-MODIFIED CROPS; PLANT PROTEOME
ANALYSIS; HUMAN ALLERGENICITY; ORAL TOLERANCE; PEANUT ALLERGY; MURINE
MODEL; PROTEINS; RESPONSES; MICE
AB Food allergy is a potential risk associated with use of transgenic proteins in crops. Currently, safety assessment involves consideration of the source of the introduced protein, in silico amino acid sequence homology comparisons to known allergens, physicochemical properties, protein abundance in the crop, and, when appropriate, specific immunoglobulin E binding studies. Recently conducted research presented at an International Life Sciences Institute/Health and Environmental Sciences Institute-hosted workshop adds to the scientific foundation for safety assessment of transgenic proteins in five areas: structure/activity, serum screening, animal models, quantitative proteomics, and basic mechanisms. A web-based tool is now available that integrates a database of allergenic proteins with a variety of computational tools which could be used to improve our ability to predict allergenicity based on structural analysis. A comprehensive strategy and model protocols have been developed for conducting meaningful serum screening, an extremely challenging process. Several animal models using oral sensitization with adjuvant and one dermal sensitization model have been developed and appear to distinguish allergenic from non-allergenic food extracts. Data presented using a mouse model suggest that pepsin resistance is indicative of allergenicity. Certain questions remain to be addressed before considering animal model validation. Gel-free mass spectrometry is a viable alternative to more labor-intensive approaches to quantitative proteomics. Proteomic data presented on four nontransgenic varieties of soy suggested that if known allergen expression in genetically modified crops falls within the range of natural variability among commercial varieties, there appears to be no need to test further. Finally, basic research continues to elucidate the etiology of food allergy.
C1 [Selgrade, MaryJane K.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Bowman, Christal C.] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Ladics, Gregory S.] DuPont Co Inc, DuPont Crop Genet, Wilmington, DE 19880 USA.
[Privalle, Laura] BASF Plant Sci, Res Triangle Pk, NC 27709 USA.
[Laessig, Susan A.] US EPA, Natl Ctr Environm Res, Off Res & Dev, Washington, DC 20004 USA.
RP Selgrade, MK (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM selgrade.maryjane@epa.gov
NR 46
TC 22
Z9 25
U1 3
U2 40
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUL
PY 2009
VL 110
IS 1
BP 31
EP 39
DI 10.1093/toxsci/kfp075
PG 9
WC Toxicology
SC Toxicology
GA 460YB
UT WOS:000267227800003
PM 19363142
ER
PT J
AU Nesnow, S
Ward, W
Moore, T
Ren, HZ
Hester, SD
AF Nesnow, Stephen
Ward, William
Moore, Tanya
Ren, Hongzu
Hester, Susan D.
TI Discrimination of Tumorigenic Triazole Conazoles from Phenobarbital by
Transcriptional Analyses of Mouse Liver Gene Expression
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE conazoles; triadimefon; phenobarbital; propiconazole; transcriptional
analyses; tumorigenesis; human relevance
ID CONSTITUTIVE ANDROSTANE RECEPTOR; PREGNANE-X-RECEPTOR; HUMAN
HEPATOCELLULAR-CARCINOMA; CELL-PROLIFERATION; IN-VIVO;
ENZYMATIC-ACTIVITIES; TUMOR PROMOTION; RISK-ASSESSMENT; MICE; INDUCTION
AB Conazoles are fungicides used to control fungal growth in environmental settings and to treat humans with fungal infections. Mouse hepatotumorigenic conazoles display many of the same hepatic toxicologic responses as the mouse liver carcinogen phenobarbital (PB): constitutive androstane receptor (CAR) activation, hypertrophy, Cyp2b induction, and increased cell proliferation. The goal of this study was to apply transcriptional analyses to hepatic tissues from mice exposed to PB, propiconazole (Pro) or triadimefon (Tri) at tumorigenic exposure levels to reveal similarities and differences in response among these treatments. Mice were administered diets containing PB (850 ppm), Pro (2500 ppm), or Tri (1800 ppm) for 4 and 30 days. Targeted transcriptomic analyses were conducted at the gene level examining differentially expressed genes (DEGs), and subsets of DEGs: cell cycle genes, and transcription factors. Analyses were also conducted on function, pathway and network levels examining Ingenuity Pathway Analysis Tox Lists and Canonical Pathways, and Gene-Go MetaCore dynamic networks and their central hubs. Genes expressed by PB or the two conazoles were also compared with those genes associated with human hepatocellular cancer. The results from these analyses indicated greater differences between PB and the two conazoles than similarities. Significant commonalities between the two conazole treatments were also noted. We posit that the transcriptional profiles of tissues exposed to toxic chemicals inherently contain their mechanisms of toxicity. We conclude that although PB and these 2 conazoles induce mouse liver tumors and exhibit similar toxicological responses, their transcriptional profiles are significantly different and thus their mechanisms of tumorigenic action are likely to differ.
C1 [Nesnow, Stephen; Ward, William; Moore, Tanya; Ren, Hongzu; Hester, Susan D.] US EPA, Div Environm Carcinogenesis, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Nesnow, S (reprint author), US EPA, Div Environm Carcinogenesis, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, B143-06,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM nesnow.stephen@epa.gov
RI Moreira, Eder/B-2309-2010
FU National Health and Environmental Effects Research Laboratory; U.S.
Environmental Protection Agency
FX The research described in this article has been reviewed by the National
Health and Environmental Effects Research Laboratory, U.S. Environmental
Protection Agency, and approved for publication. Approval does not
signify that the contents necessarily reflect the views and the policies
of the Agency, nor does mention of trade names or commercial products
constitute endorsement or recommendation for use.
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PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUL
PY 2009
VL 110
IS 1
BP 68
EP 83
DI 10.1093/toxsci/kfp076
PG 16
WC Toxicology
SC Toxicology
GA 460YB
UT WOS:000267227800007
PM 19363144
ER
PT J
AU Martin, MT
Mendez, E
Corum, DG
Judson, RS
Kavlock, RJ
Rotroff, DM
Dix, DJ
AF Martin, Matthew T.
Mendez, Elizabeth
Corum, Daniel G.
Judson, Richard S.
Kavlock, Robert J.
Rotroff, Daniel M.
Dix, David J.
TI Profiling the Reproductive Toxicity of Chemicals from Multigeneration
Studies in the Toxicity Reference Database
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE pesticides; relational database; reproductive toxicity; toxicity
profiling
AB Multigeneration reproduction studies are used to characterize parental and offspring systemic toxicity, as well as reproductive toxicity of pesticides, industrial chemicals and pharmaceuticals. Results from 329 multigeneration studies on 316 chemicals have been digitized into standardized and structured toxicity data within the Toxicity Reference Database (ToxRefDB). An initial assessment of data quality and consistency was performed prior to profiling these environmental chemicals based on reproductive toxicity and associated toxicity endpoints. The pattern of toxicity across 75 effects for all 316 chemicals provided sets of chemicals with similar in vivo toxicity for future predictive modeling. Comparative analysis across the 329 studies identified chemicals with sensitive reproductive effects, based on comparisons to chronic and subchronic toxicity studies, as did the cross-generational comparisons within the multigeneration study. The general pattern of toxicity across all chemicals and the more focused comparative analyses identified 19 parental, offspring and reproductive effects with a high enough incidence to serve as targets for predictive modeling that will eventually serve as a chemical prioritization tool spanning reproductive toxicities. These toxicity endpoints included specific reproductive performance indices, male and female reproductive organ pathologies, offspring viability, growth and maturation, and parental systemic toxicities. Capturing this reproductive toxicity data in ToxRefDB supports ongoing retrospective analyses, test guideline revisions, and computational toxicology research.
C1 [Martin, Matthew T.; Corum, Daniel G.; Judson, Richard S.; Kavlock, Robert J.; Rotroff, Daniel M.; Dix, David J.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Mendez, Elizabeth] US EPA, Div Hlth Effects, Off Pesticide Programs, Washington, DC 20460 USA.
RP Martin, MT (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, MD D343-03,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM martin.matt@epa.gov
RI Martin, Matthew/A-1982-2013;
OI Martin, Matthew/0000-0002-8096-9908; Judson, Richard/0000-0002-2348-9633
FU The United States Environmental Protection Agency; Office of Research
and Development
FX Disclaimer: The United States Environmental Protection Agency through
its Office of Research and Development funded and managed the research
described here. It has been subjected to Agency administrative review
and approved for submission and peer review.
NR 24
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U1 2
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUL
PY 2009
VL 110
IS 1
BP 181
EP 190
DI 10.1093/toxsci/kfp080
PG 10
WC Toxicology
SC Toxicology
GA 460YB
UT WOS:000267227800016
PM 19363143
ER
PT J
AU Hazari, MS
Haykal-Coates, N
Winsett, DW
Costa, DL
Farraj, AK
AF Hazari, Mehdi S.
Haykal-Coates, Najwa
Winsett, Darrell W.
Costa, Daniel L.
Farraj, Aimen K.
TI Continuous Electrocardiogram Reveals Differences in the Short-Term
Cardiotoxic Response of Wistar-Kyoto and Spontaneously Hypertensive Rats
to Doxorubicin
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE electrocardiogram; doxorubicin; cardiotoxicity; hypertension
ID OIL FLY-ASH; HEART-FAILURE; MYOCARDIAL-INFARCTION; CARDIAC-ARRHYTHMIA;
AIR-POLLUTION; MODEL; PARTICLES; ISCHEMIA; CARDIOMYOPATHY;
SUSCEPTIBILITY
AB Electrocardiography (ECG) is one of the standard technologies used to monitor and assess cardiac function, and provide insight into the mechanisms driving myocardial pathology. Increased understanding of the effects of cardiovascular disease on rat ECG may help make ECG assessments in rat toxicology studies routine, thus facilitating continuous measurement of functional decrements associated with cardiotoxicant exposure. These studies seek to test the hypothesis that hypertensive rats are more susceptible to the short-term cardiotoxic effects of doxorubicin (DOX) when compared with normotensive rats with respect to continuously measured ECG endpoints. Male Wistar-Kyoto (WKY) and spontaneously hypertensive (SH) rats surgically implanted with radiotelemeters were treated once a week for three weeks with either vehicle, 1.25 (low), 2.5 (medium), or 5 (high) mg/kg DOX (i.p.). ECG, heart rate (HR), and core body temperature (T(co)) were continuously monitored during the 1-week baseline and throughout the experimental period until rats were sacrificed 24 h after the third injection. DOX prevented normal body weight gain in both strains and significantly decreased diurnal HR and T(co) of high DOX SH rats. In the ECG, SH rats had prolonged baseline PR intervals and QT(c) when compared with WKY rats. All DOX-treated WKY rats subsequently developed PR interval prolongation; however only those treated with high DOX had increased QT(c). DOX caused an increase in ST interval in SH rats, and resulted in ECG morphology changes. The number of arrhythmias due to DOX was increased in both strains. In conclusion, ECG analysis can reveal underlying cardiovascular disease as a risk factor in the heart's response to toxicant-induced injury in the rat; and be a valuable tool to evaluate baseline vulnerability and assess cardiotoxicity.
C1 [Hazari, Mehdi S.; Haykal-Coates, Najwa; Winsett, Darrell W.; Farraj, Aimen K.] US EPA, Expt Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Costa, Daniel L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Hazari, MS (reprint author), US EPA, Expt Toxicol Div, 109 Alexander Dr,B143-01, Res Triangle Pk, NC 27711 USA.
EM hazari.mehdi@epa.gov
FU Environmental Protection Agency, United States Government
FX Environmental Protection Agency, United States Government.
NR 53
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U1 3
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUL
PY 2009
VL 110
IS 1
BP 224
EP 234
DI 10.1093/toxsci/kfp092
PG 11
WC Toxicology
SC Toxicology
GA 460YB
UT WOS:000267227800020
PM 19407338
ER
PT J
AU Goetz, AK
Dix, DJ
AF Goetz, Amber K.
Dix, David J.
TI Toxicogenomic effects common to triazole antifungals and conserved
between rats and humans
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Myclobutanil; Propiconazole; Triadimefon; Toxicogenomics; CAR; PXR
ID CONAZOLE FUNGICIDES; GENE-EXPRESSION; TRANSCRIPTIONAL PROFILES; TOXICITY
PROFILES; NUCLEAR RECEPTORS; HUMAN HEPATOCYTES; PROPICONAZOLE;
MYCLOBUTANIL; TRIADIMEFON; LIVER
AB The triazole antifungals myclobutanil, propiconazole and triadimefon cause varying degrees of hepatic toxicity and disrupt steroid hormone homeostasis in rodent in vivo models. To identify biological pathways consistently modulated across multiple timepoints and various study designs, gene expression profiling was conducted on rat livers from three separate studies with triazole treatment groups ranging from 6 h after a single oral gavage exposure, to prenatal to adult exposures via feed. To explore conservation of responses across species, gene expression from the rat liver studies were compared to in vitro data from rat and human primary hepatocytes exposed to the triazoles. Toxicogenomic data on triazoles from 33 different treatment groups and 135 samples (microarrays) identified thousands Of probe sets and dozens of pathways differentially expressed across time, dose, and species - many of these were common to all three triazoles, or conserved between rodents and humans. Common and conserved pathways included androgen and estrogen metabolism, xenobiotic metabolism signaling through CAR and PXR, and CYP mediated metabolism. Differentially expressed genes included the Phase I xenobiotic, fatty acid, sterol and steroid metabolism genes Cyp2b2 and CYP2B6, Cyp3a1 and CYP3A4, and Cyp4a22 and CYP4A11; Phase 11 conjugation enzyme genes Ugt1a1 and UGT1A1: and Phase III ABC transporter genes Abcb1 and ABCB1. Gene expression changes caused by all three triazoles in liver and hepatocytes were concentrated in biological pathways regulating lipid, sterol and steroid homeostasis, identifying a potential common mode of action conserved between rodents and humans. Modulation of hepatic sterol and steroid metabolism is a plausible mode of action for changes in serum testosterone and adverse reproductive outcomes observed in rat studies, and may be relevant to human risk assessment. Published by Elsevier Inc.
C1 [Goetz, Amber K.; Dix, David J.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Goetz, Amber K.] N Carolina State Univ, Dept Environm & Mol Toxicol, Raleigh, NC 27695 USA.
RP Dix, DJ (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Mail Drop D343-03, Res Triangle Pk, NC 27711 USA.
EM dix.david@epa.gov
RI Moreira, Eder/B-2309-2010
FU EPA/North Carolina State University Cooperative Training Agreement
[CT826512010]
FX The authors thank Drs Wenjun Bao and Russ Wolfinger (SAS Inc., Cary, NC)
for expert advice on data analysis: and Drs Hongzu Ren (EPA) and Stephen
Ferguson (CellzDirect Inc., Durham, NQ for excellent technical Support.
We also thank Dr Douglas Wolf (EPA/ORD) for technical review of this
manuscript; and Ms. Jennifer Hill for excellent management of the EPA
contracts with Expression Analysis Inc. (Durham, INC), and CellzDirect.
Microarrays and reagents for a portion of this study were provided by
Affymetrix Inc. (Santa Clara, CA) as part of a Materials Cooperative
Research and Development Agreement with EPA. AKG was supported by
EPA/North Carolina State University Cooperative Training Agreement
#CT826512010.
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U2 20
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JUL 1
PY 2009
VL 238
IS 1
BP 80
EP 89
DI 10.1016/j.taap.2009.04.016
PG 10
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 458IF
UT WOS:000267009800010
PM 19409404
ER
PT J
AU Teske, ME
Miller, PCH
Thistle, HW
Birchfield, NB
AF Teske, M. E.
Miller, P. C. H.
Thistle, H. W.
Birchfield, N. B.
TI INITIAL DEVELOPMENT AND VALIDATION OF A MECHANISTIC SPRAY DRIFT MODEL
FOR GROUND BOOM SPRAYERS
SO TRANSACTIONS OF THE ASABE
LA English
DT Article
DE AGDISP; Ground sprayer; Lagrangian modeling; Spray drift
ID AERIAL APPLICATIONS; HYDRAULIC NOZZLES; LIQUID SPRAY; FIELD; SIMULATION;
VARIABLES; AIR; VELOCITY; AGDISP; CODE
AB This article summarizes the initial development of a mechanistic spray drift model for ground boom sprayers, built upon the same analytical Lagrangian approach used in the aerial spray model AGDISP. For ground boom sprayers the wake and turbulence of the aircraft are removed and more detailed modeling of the nozzle jets (and jet entrainment) is included. The model predicts the spray deposition downwind from the application area for any set of initial conditions, and recovers results compared with Spray Drift Task Force and Canadian field datasets for two ground sprayer nozzle types.
C1 [Teske, M. E.] Continuum Dynam Inc, Ewing, NJ 08616 USA.
[Miller, P. C. H.] Silsoe Spray Applicat Unit, Bedford, England.
[Thistle, H. W.] US Forest Serv, USDA, Morgantown, WV USA.
[Birchfield, N. B.] US EPA, Washington, DC 20460 USA.
RP Teske, ME (reprint author), Continuum Dynam Inc, 34 Lexington Ave, Ewing, NJ 08616 USA.
EM milt@continuum-dynamics.com
NR 37
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U1 0
U2 6
PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS
PI ST JOSEPH
PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA
SN 0001-2351
J9 T ASABE
JI Trans. ASABE
PD JUL-AUG
PY 2009
VL 52
IS 4
BP 1089
EP 1097
PG 9
WC Agricultural Engineering
SC Agriculture
GA 494BC
UT WOS:000269783100005
ER
PT J
AU Grim, KC
Wolfe, MJ
Edwards, M
Kaufman, J
Onjukka, S
Moran, P
Wolf, JC
AF Grim, K. C.
Wolfe, M. J.
Edwards, M.
Kaufman, J.
Onjukka, S.
Moran, P.
Wolf, J. C.
TI Epizootic Ameloblastomas in Chinook Salmon (Oncorhynchus tshawytscha) of
the Northwestern United States
SO VETERINARY PATHOLOGY
LA English
DT Article
DE Ameloblastoma; Chinook salmon; epizootic; Oncorhynchus tshawytscha
ID EFFECTIVE POPULATION-SIZE; LINKAGE DISEQUILIBRIUM; ELECTRON-MICROSCOPY;
PACIFIC SALMON; CELL-LINE; FISH; VIRUS; CARCINOGENESIS; PAPILLOMA;
NEOPLASMS
AB Abnormal growths were observed on the lips and in the oral cavities of 2- and 3-year-old Chinook salmon (Oncorhynchus tshawytscha) maintained in one freshwater and one saltwater captive fish-rearing facility in the Columbia River (Pacific Northwest). Initially presenting as bilaterally symmetrical, red, irregular plaques on oral mucosal surfaces, the lesions developed progressively into large, disfiguring masses. Of the 502 natural parr collected for captive broodstock, 432 (86%) displayed these tumors, whereas cohort salmon (i.e., same year classes) in these same facilities remained unaffected. Morphologically similar neoplasms were collected occasionally from adult Chinook salmon that had returned to their natal streams. Histologic features of the tumors suggested that they were derived from the portion of dental lamina destined to form tooth root sulci; therefore, these neoplasms were diagnosed as ameloblastomas. The lesions also resembled archived specimens of Chinook salmon oral tumors, which had been described decades earlier. Etiologic investigations performed during the current outbreak included bacteriologic, virologic, genetic, ultrastructural analyses, and cohabitation exposure studies. Results of these efforts did not indicate an obvious genetic basis for this syndrome, attempts to isolate potentially causative viruses or bacteria were negative, and disease transmission to naive fish was unsuccessful. A few intracytoplasmic hexagonal structures, possibly consistent with viral particles (similar to 100 nm), were observed ultrastructurally in a tumor cell from 1 of 6 specimens submitted for transmission electron microscopy. Although the presence of these particles does not constitute sufficient evidence for causality, an infectious or multifactorial etiology seems plausible.
C1 [Wolfe, M. J.; Wolf, J. C.] Expt Pathol Labs Inc, Registry Tumors Lower Anim, Sterling, VA 20166 USA.
[Grim, K. C.] US EPA, Off Sci Coordinat & Policy, Washington, DC 20460 USA.
[Grim, K. C.] Smithsonian Natl Zool Pk, Conservat & Res Ctr, Ctr Species Survival, Front Royal, VA USA.
[Edwards, M.] Enterprise Field Off, Nez Perce Tribe Dept Fisheries Resources Manageme, Enterprise, OR USA.
[Kaufman, J.] Oregon State Univ, Dept Microbiol, Oregon Dept Fish & Wildlife, Corvallis, OR 97331 USA.
[Onjukka, S.] Eastern Oregon Univ, Oregon Dept Fish & Wildlife, Fish Hlth Serv, La Grande, OR USA.
[Moran, P.] NOAA, NW Fisheries Sci Ctr, Conservat Biol Div, Seattle, WA USA.
RP Wolf, JC (reprint author), Expt Pathol Labs Inc, Registry Tumors Lower Anim, 45600 Terminal Dr, Sterling, VA 20166 USA.
EM jwolf@epl-inc.com
FU Experimental Pathology Laboratories, Inc. [N02-CB-27034]; Bonneville
Power Administration [198909600]
FX This project was performed, in part, by using the services provided by
the National Cancer Institute's Registry of Tumors in Lower Animals,
operated under contract by Experimental Pathology Laboratories, Inc.,
N02-CB-27034. We also thank the contributions and efforts of Phyllis
Spero (RTLA) and Debbie Haegele (RTLA) for organizing slide materials.
We thank Dr. Richard R. Dubielzig, DVM, for aiding in the diagnosis of
these tumors, Dr. Jerry R. Heidel, DVM, for histopathologic work on
tumor tissues, Dr. Lee Harrell, DVM, for tissue collection and input on
managing this problem in the Captive Broodstock Program. We also thank
Dr. James Casey for conducting viral-probe testing, Marla Chaney for
assistance with tumor sampling and taking care of these fish, Sharon
Vendshus for performing numerous fish necropsies, and Glenda O'Connor
for sampling and necropsying the fish from Northeast Oregon. This work
was supported in part by Bonneville Power Administration project
198909600.
NR 41
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U1 1
U2 5
PU AMER COLL VET PATHOLOGIST
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0300-9858
J9 VET PATHOL
JI Vet. Pathol.
PD JUL
PY 2009
VL 46
IS 4
BP 622
EP 635
DI 10.1354/vp.08-VP-0150-W-FL
PG 14
WC Pathology; Veterinary Sciences
SC Pathology; Veterinary Sciences
GA 475UY
UT WOS:000268388700011
PM 19276053
ER
PT J
AU Chen, KF
Kao, CM
Wu, LC
Surampalli, RY
Liang, SH
AF Chen, K. F.
Kao, C. M.
Wu, L. C.
Surampalli, R. Y.
Liang, S. H.
TI Methyl Tert-Butyl Ether (MTBE) Degradation by Ferrous Ion-Activated
Persulfate Oxidation: Feasibility and Kinetics Studies
SO WATER ENVIRONMENT RESEARCH
LA English
DT Article
DE Methyl tert-butyl ether (MTBE); persulfate; ferrous ion; Fenton's
reaction; in situ chemical oxidation (ISCO)
ID IN-SITU REMEDIATION; AQUEOUS-SOLUTION; MECHANISM; WATER; FATE; TCE;
PEROXYDISULFATE; GROUNDWATER; ENVIRONMENT; REAGENT
AB The objective of this study was to evaluate the feasibility of using ferrous ion-activated persulfate oxidation to remediate groundwater contaminated with methyl tert-butyl ether (MTBE). In this study, batch experiments were conducted to evaluate the effects of various factors on the efficiency of MTBE degradation including persulfate concentrations, ferrous ion concentrations, and persulfate coupled with hydrogen peroxide. Results show that ferrous ion-activated persulfate oxidation was capable of degrading MTBE efficiently. Persulfate and ferrous ion concentrations correlated with MTBE degradation rates. However, excess addition of ferrous ion resulted in decreased MTBE degrading rates most likely because of competition for sulfate free radicals between ferrous ion and MTBE. Two main byproducts of MTBE degradation, tert-butyl formate and tert-butyl alcohol, were detected in the experiments; both were, however, subsequently degraded. Results of sulfate analysis show that proper addition of ferrous ion could prevent unnecessary persulfate decomposition. Water Environ. Res., 81, 687 (2009).
C1 [Chen, K. F.] Natl Chi Nan Univ, Dept Civil Engn, Nantou 545, Taiwan.
[Kao, C. M.; Liang, S. H.] Natl Sun Yat Sen Univ, Inst Environm Engn, Kaohsiung 80424, Taiwan.
[Wu, L. C.] CPC Corp, Tainan, Taiwan.
[Surampalli, R. Y.] US EPA, Kansas City, KS USA.
RP Chen, KF (reprint author), Natl Chi Nan Univ, Dept Civil Engn, 1 Univ Rd, Nantou 545, Taiwan.
EM kfchen@ncnu.edu.tw
FU Apollo Technology Corp., Ltd., Taiwan
FX This study was funded by the Apollo Technology Corp., Ltd., Taiwan. The
authors also thank Mr. Y. Y. Li of the Department of Marine
Environmental Engineering, National Kaohsiung Marine University, Taiwan,
for his assistance throughout this project. The views or opinions
expressed in this article are those of the writers and should not be
construed as opinions of the U. S. Environmental Protection Agency.
NR 39
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U1 3
U2 29
PU WATER ENVIRONMENT FEDERATION
PI ALEXANDRIA
PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA
SN 1061-4303
J9 WATER ENVIRON RES
JI Water Environ. Res.
PD JUL
PY 2009
VL 81
IS 7
BP 687
EP 694
DI 10.2175/106143008X370539
PG 8
WC Engineering, Environmental; Environmental Sciences; Limnology; Water
Resources
SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater
Biology; Water Resources
GA 475DK
UT WOS:000268338400006
PM 19691249
ER
PT J
AU Rashleigh, B
Hardwick, D
Roux, D
AF Rashleigh, Brenda
Hardwick, Devlyn
Roux, Dirk
TI Fish assemblage patterns as a tool to aid conservation in the Olifants
River catchment (East), South Africa
SO WATER SA
LA English
DT Article
DE focal species; dams; species richness; land use; conservation planning
ID KRUGER-NATIONAL-PARK; BIODIVERSITY CONSERVATION; BIOLOGICAL INTEGRITY;
PROTECTED AREAS; WATER; MANAGEMENT; INDEX; ECOSYSTEMS; DIVERSITY;
ZIMBABWE
AB South Africa has committed to address freshwater conservation at the catchment scale, using a combination of landscape-level and species-level features as surrogates of freshwater biodiversity. To support this work, we examined fishes in the Olifants River catchment, where multiple anthropogenic pressures affect streams. Patterns in fish assemblage data across 88 sites were analysed and related to landscape environmental variables using statistical techniques of multivariate ordination, cluster analysis, and regression tree analysis. We identified 6 distinct fish assemblage types, which were separated by altitude and human influence, primarily dry-land cropping and dams. In the tipper reaches of the catchment, we identified a faunal shift from Barbus neefi, which occurred in less impacted sites, to B. anoplus and Tilapia sparrmanii, which were favored in cropland and mixed cropland/urban settings, respectively. The fish assemblage of the middle section of the catchment was not unique, but supported one species, Chiloglanis pretoriae, that could be considered a focal species for conservation. The low altitude, high-runoff section of the catchment supported the most species. However, species richness increased in association with dams, through the addition of species that are more tolerant of flow and physicochemical modifications. Thus, species richness may not be an optimal conservation target for this system. Rather, a series of indicators will be necessary to track and measure conservation success in the Olifants catchment.
C1 [Rashleigh, Brenda] Univ Witwatersrand, Sch Geog Archaeol & Environm Studies, ZA-2050 Wits, South Africa.
[Rashleigh, Brenda] US EPA, Athens, GA 30605 USA.
[Roux, Dirk] Monash Univ, ZA-1725 Roodepoort, South Africa.
RP Rashleigh, B (reprint author), Univ Witwatersrand, Sch Geog Archaeol & Environm Studies, Private Bag 3, ZA-2050 Wits, South Africa.
EM Rashleigh.Brenda@epa.gov
RI Roux, Dirk/F-2894-2012
OI Roux, Dirk/0000-0001-7809-0446
FU US Embassy Science Fellows Program through the US Department of State
FX We acknowledge support of the US Embassy Science Fellows Program through
the US Department of State. Special thanks to Nikki Brajevich (U.S.
Embassy Pretoria) and Peter J Ashton (CSIR); to Dan McGarvey (U.S. EPA)
for a helpful review; and to two anonymous reviewers whose comments were
extremely helpful. We also thank Helen Dallas (UCT) for her kind help
with tile rivers database. Although this work was reviewed by US EPA and
approved for publication, it may not necessarily reflect official Agency
policy.
NR 52
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U1 0
U2 6
PU WATER RESEARCH COMMISSION
PI PRETORIA
PA PO BOX 824, PRETORIA 0001, SOUTH AFRICA
SN 0378-4738
J9 WATER SA
JI Water SA
PD JUL
PY 2009
VL 35
IS 4
BP 517
EP 524
PG 8
WC Water Resources
SC Water Resources
GA 491YU
UT WOS:000269620900017
ER
PT J
AU Thomas, T
Bahadori, T
Savage, N
Thomas, K
AF Thomas, Treye
Bahadori, Tina
Savage, Nora
Thomas, Karluss
TI Moving toward exposure and risk evaluation of nanomaterials: challenges
and future directions
SO WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
LA English
DT Review
ID WALL CARBON NANOTUBES; INFLAMMATORY RESPONSE; RESEARCH STRATEGIES;
PULMONARY TOXICITY; SAFETY EVALUATION; NANOPARTICLES; SCIENCE; SIZE;
MICE
AB Nanotechnology, the commercial development of engineered nanomaterials, promises breakthrough innovations by enhancing the performance of existing consumer products and enabling development of new devices, architectures, and applications. Although these materials and applications are being developed at an explosive pace, a fundamental understanding of any potential human health and environmental risks resulting from exposure throughout the lifecycle of these materials has not advanced as rapidly. Past experience has demonstrated that successful introduction of a new technology occurs more readily if it is precipitated by a robust appreciation for any inherent risks associated with the technology. Such understanding allows the timely development of occupational and consumer exposure standards that might be needed to protect human health and the environment. Although risk is recognized as the product of hazard and exposure, too often exposure patterns are poorly characterized, and risk is based primarily or exclusively on the hazard characterization. The extent of exposure to nanomaterials in currently available commercial products is relatively unknown. Given the number of commercial products that claim to contain engineered nanomaterials, it is possible that human and environmental exposure to these materials is widespread. This paper is intended to highlight the importance of exposure assessment for determining the potential risks of nanomaterials. In essence, this is a call to action to the community of exposure scientists, toxicologists, and risk assessors to develop, consider, and incorporate requisite exposure information in the risk assessment of nanomaterials. Without an integrated approach, it will be difficult to meaningfully assess the risks of nanomaterials, realize their potential benefits, and foster their sustainable development. (C) 2009 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2009 4 426-433
C1 [Thomas, Treye] US Consumer Prod Safety Commiss, Bethesda, MD USA.
[Bahadori, Tina] Amer Chem Council Long Range Res Initiat, Arlington, VA USA.
[Savage, Nora] US EPA, Washington, DC USA.
[Thomas, Karluss] Silicones Environm Hlth & Safety Council N Amer, Herndon, VA USA.
RP Thomas, T (reprint author), US Consumer Prod Safety Commiss, Bethesda, MD USA.
EM tthomas@cpsc.gov
NR 25
TC 16
Z9 16
U1 0
U2 21
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-5116
EI 1939-0041
J9 WIRES NANOMED NANOBI
JI Wiley Interdiscip. Rev.-Nanomed. Nanobiotechnol.
PD JUL-AUG
PY 2009
VL 1
IS 4
BP 426
EP 433
DI 10.1002/wnan.34
PG 8
WC Nanoscience & Nanotechnology; Medicine, Research & Experimental
SC Science & Technology - Other Topics; Research & Experimental Medicine
GA 585PU
UT WOS:000276839700007
PM 20049808
ER
PT J
AU Kellogg, RB
Willis, RD
AF Kellogg, Robert B.
Willis, Robert D.
TI Library optimization in EDXRF spectral deconvolution for multi-element
analysis of ambient aerosols
SO X-RAY SPECTROMETRY
LA English
DT Article
ID MASS
AB In multi-element analysis of atmospheric aerosols, attempts are made to fit overlapping elemental spectral lines for many elements that may be undetectable in samples due to low concentrations. Fitting with many library reference spectra has the unwanted effect of raising the analytical uncertainty of overlapping elements. By carefully choosing the order of elemental processing, library reference spectra can be omitted for non-analyte lines of undetected elements without loss of information, thus lowering the number of library spectra needed for the fit and thereby reducing the uncertainty. The magnitude of the reduction so achieved is shown for blanks and a sample for 64 elements. Copyright (C) 2009 John Wiley & Sons, Ltd.
C1 [Kellogg, Robert B.] Alion Sci & Technol, Res Triangle Pk, NC 27709 USA.
[Willis, Robert D.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Kellogg, RB (reprint author), Alion Sci & Technol, POB 12313, Res Triangle Pk, NC 27709 USA.
EM kellogg.robert@epa.gov
FU US Environmental Protection Agency through its Office of Research and
Development [EP-D-05-065]
FX The authors wish to thank Dr. Teri L. Conner of the US Environmental
Protection Agency for her critical review of the manuscript. The US
Environmental Protection Agency through its Office of Research and
Development funded and managed the research described here under
Contract EP-D-05-065 with Alion Science and Technology. The views
expressed in this paper are those of the authors and do not necessarily
reflect the views or policies of the US Environmental Protection Agency.
Mention of trade names or commercial products does not constitute
endorsement or recommendation for use.
NR 11
TC 4
Z9 4
U1 0
U2 3
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 0049-8246
J9 X-RAY SPECTROM
JI X-Ray Spectrom.
PD JUL-AUG
PY 2009
VL 38
IS 4
BP 283
EP 286
DI 10.1002/xrs.1169
PG 4
WC Spectroscopy
SC Spectroscopy
GA 464HM
UT WOS:000267496000003
ER
PT J
AU Sahle-Demessie, E
Devulapelli, VG
AF Sahle-Demessie, E.
Devulapelli, Venu Gopal
TI Oxidation of methanol and total reduced sulfur compounds with ozone over
V2O5/TiO2 catalyst: Effect of humidity
SO APPLIED CATALYSIS A-GENERAL
LA English
DT Article
DE Catalytic oxidation; Ozone; Methanol; Dimethyl Sulfide; Methanethiol;
Effect of humidity
ID MARINE BOUNDARY-LAYER; DIMETHYL SULFIDE; DESTRUCTIVE OXIDATION; OXIDE
CATALYSTS; CO OXIDATION; FLY-ASH; WATER; METHANETHIOL; FORMALDEHYDE;
(CH3)(2)S-2
AB The purpose of this study was to investigate the feasibility of using ozone-enhanced catalytic oxidation for the treatment of high volume, low concentration (HVLC) waste gas streams at a Kraft pulp and paper mill that contain hazardous air pollutants such as methanol (CH3OH), reduced sulfur compounds (TRS). including dimethyl sulfide (DMS), dimethyl disulfide (DMDS), methanethiol (MT), hydrogen sulfide (H2S), and saturated with moisture. This paper reports that ozone-enhance V2O5-TiO2 catalyzed oxidation is a stable and effective process to remove methanol and TRS compounds in the presence of moisture that has composition similar to the effluent stream coming out of a pulp mill blow tank.
The effect of moisture on the oxidation of CH3OH, MT and DMS was studied using V2O5/TiO2 as a catalyst at different feed compositions (C-methonol: 1000 and 7500 ppm; C-DMS: 250 and 1000 ppm: and C-MT: 250 and 1000 ppm) and gas hourly space velocities (37,000-150,000 h(-1)) at 250 degrees C and O-3-to-substrate mole ratio of 2.1. Conversions of methanol and TRS compounds were high and the main products were CO2, CO and SO2 with small amounts of partial oxidation products. Increasing the relative humidity of the gas stream from zero to 18,000 ppm reduced the conversion of methanol, whereas the conversion of TRS compounds was not affected, although the selectivity for partial oxidation products of TRS compounds decreased. High moisture levels have inhibition effect on the reactions because of competitive adsorption of methanol and water on to the same sites. The increase in the complete oxidation of TRS products could be due to forming hydroxyl ion radicals in presence of ozone and water molecules. Possible reaction mechanisms have been proposed for the complete oxidation of methanol and TRS compounds with ozone based on the product distribution. Published by Elsevier B.V.
C1 [Sahle-Demessie, E.; Devulapelli, Venu Gopal] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Sahle-Demessie, E (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, MS 443, Cincinnati, OH 45268 USA.
EM sahle-demessie.endalkachew@epa.gov
NR 40
TC 9
Z9 9
U1 5
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0926-860X
J9 APPL CATAL A-GEN
JI Appl. Catal. A-Gen.
PD JUN 20
PY 2009
VL 361
IS 1-2
BP 72
EP 80
DI 10.1016/j.apcata.2009.03.035
PG 9
WC Chemistry, Physical; Environmental Sciences
SC Chemistry; Environmental Sciences & Ecology
GA 459HR
UT WOS:000267092800010
ER
PT J
AU Landgren, O
Kyle, RA
Hoppin, JA
Freeman, LEB
Cerhan, JR
Katzmann, JA
Rajkumar, SV
Alavanja, MC
AF Landgren, Ola
Kyle, Robert A.
Hoppin, Jane A.
Freeman, Laura E. Beane
Cerhan, James R.
Katzmann, Jerry A.
Rajkumar, S. Vincent
Alavanja, Michael C.
TI Pesticide exposure and risk of monoclonal gammopathy of undetermined
significance in the Agricultural Health Study
SO BLOOD
LA English
DT Article
ID MULTIPLE-MYELOMA; CANCER INCIDENCE; UNITED-STATES; IOWA FARMERS;
LIFE-STYLE; OCCUPATION; MORTALITY; APPLICATORS; DEATH; MEN
AB Pesticides are associated with excess risk of multiple myeloma, albeit inconclusively. We included 678 men (30-94 years) from a well-characterized prospective cohort of restricted-use pesticide applicators to assess the risk of monoclonal gammopathy of undetermined significance (MGUS). Serum samples from all subjects were analyzed by electrophoresis performed on agarose gel; samples with a discrete or localized band were subjected to immunofixation. Age-adjusted prevalence estimates of MGUS were compared with MGUS prevalence in 9469 men from Minnesota. Associations between pesticide exposures and MGUS prevalence were assessed by logistic regression models adjusted for age and education level. Among study participants older than 50 years (n = 555), 38 were found to have MGUS, yielding a prevalence of 6.8% (95% Cl, 5.0%-9.3%). Compared with men from Minnesota, the age-adjusted prevalence of MGUS was 1.9-fold (95% Cl, 1.3- to 2.7-fold) higher among male pesticide applicators. Among applicators, a 5.6-fold (95% Cl, 1.9- to 16.6-fold), 3.9-fold (95% Cl, 1.5- to 10.0-fold), and 2.4-fold (95% Cl, 1.1- to 5.3-fold) increased risk of MGUS prevalence was observed among users of the chlorinated insecticide dieldrin, the fumigant mixture carbon-tetrachloride/carbon disulfide, and the fungicide chlorothalonil, respectively. In summary, the prevalence of MGUS among pesticide applicators was twice that in a population-based sample of men from Minnesota, adding support to the hypothesis that specific pesticides are causatively linked to myelomagenesis. (Blood. 2009; 113: 6386-6391)
C1 [Landgren, Ola] NCI, Natl Inst Hlth, Ctr Canc Res, Med Oncol Branch, Bethesda, MD 20892 USA.
[Landgren, Ola; Freeman, Laura E. Beane; Alavanja, Michael C.] NCI, Natl Inst Hlth, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
[Kyle, Robert A.; Cerhan, James R.; Katzmann, Jerry A.; Rajkumar, S. Vincent] Mayo Clin, Coll Med, Rochester, MN USA.
[Hoppin, Jane A.] Natl Inst Environm Hlth Sci, NIH, Res Triangle Pk, NC USA.
RP Landgren, O (reprint author), NCI, Natl Inst Hlth, Ctr Canc Res, Med Oncol Branch, 9000 Rockville Pike,Bldg 10 Rm 13N240, Bethesda, MD 20892 USA.
EM landgreo@mail.nih.gov
RI Beane Freeman, Laura/C-4468-2015;
OI Beane Freeman, Laura/0000-0003-1294-4124; Cerhan,
James/0000-0002-7482-178X; Rajkumar, S. Vincent/0000-0002-5862-1833
FU NCI [CA 62242, CA 107476, Z01-CP010119]; NIH; Division of Cancer
Epidemiology and Genetics (DCEG); NIEHS [Z01-ES049030]
FX This work was supported by NCI (research grants CA 62242 and CA 107476);
the Intramural Research Program of the NIH, NCI, Division of Cancer
Epidemiology and Genetics (DCEG); the NIEHS (Z01-ES049030); and the NCI
(Z01-CP010119).
NR 46
TC 61
Z9 61
U1 0
U2 7
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA
SN 0006-4971
J9 BLOOD
JI Blood
PD JUN 18
PY 2009
VL 113
IS 25
BP 6386
EP 6391
DI 10.1182/blood-2009-02-203471
PG 6
WC Hematology
SC Hematology
GA 459XV
UT WOS:000267147400021
PM 19387005
ER
PT J
AU Tudor, C
Marchese, FP
Hitti, E
Aubareda, A
Rawlinson, L
Gaestel, M
Blackshear, PJ
Clark, AR
Saklatvala, J
Dean, JLE
AF Tudor, Corina
Marchese, Francesco P.
Hitti, Edward
Aubareda, Anna
Rawlinson, Lesley
Gaestel, Matthias
Blackshear, Perry J.
Clark, Andrew R.
Saklatvala, Jeremy
Dean, Jonathan L. E.
TI The p38 MAPK pathway inhibits tristetraprolin-directed decay of
interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages
SO FEBS LETTERS
LA English
DT Article
DE p38 Mitogen-activated protein kinase; Tristetraprolin; Interleukin-10;
COX-2
ID ACTIVATED PROTEIN-KINASE; NECROSIS-FACTOR-ALPHA; AU-RICH ELEMENTS;
GENE-EXPRESSION; STABILITY; DEADENYLATION; CYCLOOXYGENASE-2;
INVOLVEMENT; REGULATOR; ARTHRITIS
AB p38 mitogen-activated protein kinase (MAPK) stabilises pro-inflammatory mediator mRNAs by inhibiting AU-rich element (ARE)-mediated decay. We show that in bone-marrow derived murine macrophages tristetraprolin (TTP) is necessary for the p38 MAPK-sensitive decay of several pro-inflammatory mRNAs, including cyclooxygenase-2 and the novel targets interleukin (IL)-6, and IL-1 alpha. TTP(-/-) macrophages also strongly overexpress IL-10, an anti-inflammatory cytokine that constrains the production of the IL-6 despite its disregulation at the post-transcriptional level. TTP directly controls IL-10 mRNA stability, which is increased and insensitive to inhibition of p38 MAPK in TTP(-/-) macrophages. Furthermore, TTP enhances deadenylation of an IL-10 3'-untranslated region RNA in vitro. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
C1 [Tudor, Corina; Marchese, Francesco P.; Aubareda, Anna; Rawlinson, Lesley; Clark, Andrew R.; Saklatvala, Jeremy; Dean, Jonathan L. E.] Univ London Imperial Coll Sci Technol & Med, Kennedy Inst Rheumatol Div, London W6 8LH, England.
[Hitti, Edward; Gaestel, Matthias] Hannover Med Sch, Inst Biochem, D-30625 Hannover, Germany.
[Blackshear, Perry J.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA.
RP Dean, JLE (reprint author), Univ London Imperial Coll Sci Technol & Med, Kennedy Inst Rheumatol Div, 65 Aspenlea Rd, London W6 8LH, England.
EM jonathan.dean@imperial.ac.uk
OI Clark, Andy/0000-0003-4996-8322; Gaestel, Matthias/0000-0002-4944-4652
FU BBSRC; GlaxoSmithKline; MRC; ARC
FX We thank M. Brook and J. Steitz for reagents. C. T. was supported by a
CASE studentship from the BBSRC and GlaxoSmithKline. We are also
grateful to the MRC and the ARC for support.
NR 19
TC 52
Z9 54
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-5793
J9 FEBS LETT
JI FEBS Lett.
PD JUN 18
PY 2009
VL 583
IS 12
BP 1933
EP 1938
DI 10.1016/j.febslet.2009.04.039
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 468EM
UT WOS:000267797800019
PM 19416727
ER
PT J
AU McKeen, S
Grell, G
Peckham, S
Wilczak, J
Djalalova, I
Hsie, EY
Frost, G
Peischl, J
Schwarz, J
Spackman, R
Holloway, J
de Gouw, J
Warneke, C
Gong, W
Bouchet, V
Gaudreault, S
Racine, J
McHenry, J
McQueen, J
Lee, P
Tang, Y
Carmichael, GR
Mathur, R
AF McKeen, S.
Grell, G.
Peckham, S.
Wilczak, J.
Djalalova, I.
Hsie, E. -Y.
Frost, G.
Peischl, J.
Schwarz, J.
Spackman, R.
Holloway, J.
de Gouw, J.
Warneke, C.
Gong, W.
Bouchet, V.
Gaudreault, S.
Racine, J.
McHenry, J.
McQueen, J.
Lee, P.
Tang, Y.
Carmichael, G. R.
Mathur, R.
TI An evaluation of real-time air quality forecasts and their urban
emissions over eastern Texas during the summer of 2006 Second Texas Air
Quality Study field study
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
ID SECONDARY ORGANIC AEROSOL; MULTISCALE GEM MODEL; OZONE FORMATION;
TROPOSPHERIC OZONE; UNITED-STATES; TRACE-P; PART I; ART.; HOUSTON;
CHEMISTRY
AB Forecasts of ozone (O-3) and particulate matter (diameter less than 2.5 mu m, PM2.5) from seven air quality forecast models (AQFMs) are statistically evaluated against observations collected during August and September of 2006 (49 days) through the Aerometric Information Retrieval Now (AIRNow) network throughout eastern Texas and adjoining states. Ensemble O-3 and PM2.5 forecasts created by combining the seven separate forecasts with equal weighting, and simple bias-corrected forecasts, are also evaluated in terms of standard statistical measures, threshold statistics, and variance analysis. For O-3 the models and ensemble generally show statistical skill relative to persistence for the entire region, but fail to predict high-O-3 events in the Houston region. For PM2.5, none of the models, or ensemble, shows statistical skill, and all but one model have significant low bias. Comprehensive comparisons with the full suite of chemical and aerosol measurements collected aboard the NOAA WP-3 aircraft during the summer 2006 Second Texas Air Quality Study and the Gulf of Mexico Atmospheric Composition and Climate Study (TexAQS II/GoMACCS) field study are performed to help diagnose sources of model bias at the surface. Aircraft flights specifically designed for sampling of Houston and Dallas urban plumes are used to determine model and observed upwind or background biases, and downwind excess concentrations that are used to infer relative emission rates. Relative emissions from the U. S. Environmental Protection Agency 1999 National Emission Inventory (NEI-99) version 3 emissions inventory (used in two of the model forecasts) are evaluated on the basis of comparisons between observed and model concentration difference ratios. Model comparisons demonstrate that concentration difference ratios yield a reasonably accurate measure (within 25%) of relative input emissions. Boundary layer height and wind data are combined with the observed up-wind and downwind concentration differences to estimate absolute emissions. When the NEI-99 inventory is modified to include observed NOy emissions from continuous monitors and expected NOx decreases from mobile sources between 1999 and 2006, good agreement is found with those derived from the observations for both Houston and Dallas. However, the emission inventories consistently overpredict the ratio of CO to NOy. The ratios of ethylene and aromatics to NOy are reasonably consistent with observations over Dallas, but are significantly underpredicted for Houston. Excess ratios of PM2.5 to NOy reasonably match observations for most models but the organic carbon fraction of PM2.5 is significantly underpredicted, pointing to compensating error between secondary organic aerosol (SOA) formation and primary emissions within the models' photochemistry and emissions. Rapid SOA formation associated with both Houston and Dallas is inferred to occur within 1 to 3 h downwind of the urban centers, and none of the models reproduce this feature.
C1 [McKeen, S.; Grell, G.; Peckham, S.; Djalalova, I.; Hsie, E. -Y.; Frost, G.; Peischl, J.; Schwarz, J.; Spackman, R.; Holloway, J.; Warneke, C.] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA.
[McKeen, S.; Hsie, E. -Y.; Frost, G.; Peischl, J.; Schwarz, J.; Spackman, R.; Holloway, J.; de Gouw, J.; Warneke, C.] NOAA, Div Chem Sci, Earth Syst Res Lab, Boulder, CO 80305 USA.
[Bouchet, V.; Gaudreault, S.; Racine, J.] Environm Canada, Meteorol Serv Canada, Dorval, PQ H9P 1J3, Canada.
[Carmichael, G. R.] Univ Iowa, Ctr Global & Reg Environm Res, Iowa City, IA 52242 USA.
[Wilczak, J.; Djalalova, I.] NOAA, Div Phys Sci, Earth Syst Res Lab, Boulder, CO 80305 USA.
[Gong, W.] Environm Canada, Sci & Technol Branch, Toronto, ON M3H 5T4, Canada.
[Grell, G.; Peckham, S.] NOAA, Global Sci Div, Earth Syst Res Lab, Boulder, CO 80305 USA.
[Lee, P.] NOAA, Air Resources Lab, Silver Spring, MD 20910 USA.
[Mathur, R.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[McHenry, J.] N Carolina Supercomp Ctr, Baron Adv Meteorol Syst, Res Triangle Pk, NC 27709 USA.
[McQueen, J.; Tang, Y.] NOAA, Environm Modeling Ctr, Natl Ctr Environm Predict, Natl Weather Serv, Camp Springs, MD 20746 USA.
RP McKeen, S (reprint author), Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA.
EM stuart.a.mckeen@noaa.gov
RI Warneke, Carsten/E-7174-2010; Peischl, Jeff/E-7454-2010; Holloway,
John/F-9911-2012; McKeen, Stuart/H-9516-2013; Frost,
Gregory/I-1958-2013; Hsie, Eirh-Yu/I-4449-2013; Wang,
Linden/M-6617-2014; grell, georg/B-6234-2015; schwarz,
joshua/G-4556-2013; de Gouw, Joost/A-9675-2008; Lee, Pius/D-5201-2016;
Tang, Youhua/D-5205-2016; Manager, CSD Publications/B-2789-2015
OI Peischl, Jeff/0000-0002-9320-7101; Holloway, John/0000-0002-4585-9594;
Hsie, Eirh-Yu/0000-0003-3934-9923; grell, georg/0000-0001-5214-8742;
schwarz, joshua/0000-0002-9123-2223; de Gouw, Joost/0000-0002-0385-1826;
Tang, Youhua/0000-0001-7089-7915;
FU NOAA Office of Atmospheric Research; NOAA Air Quality Program; NOAA/NWS
Office of Science and Technology
FX This research is partially funded by Early Start Funding from the NOAA
Office of Atmospheric Research, the NOAA Air Quality Program, and the
NOAA/NWS Office of Science and Technology. Credit for program support
and management is given to Paula Davidson (NOAA/NWS/OST), Steve Fine
(NOAA/ARL), and Jim Meagher (NOAA/ESRL/CSD). Michael Trainer
(NOAA/ESRL/CSD) designed and managed the WP-3 flight plans that were
instrumental in this work. The thoughtful comments of two reviewers are
highly appreciated. This work would not be possible without the
measurements collected on board the NOAA WP-3 aircraft by the following
people within NOAA/ESRL/CSD: aerosol volume measurements by Chuck Brock,
aerosol mass spectrometer measurements by Ann Middlebrook and Roya
Bahreini, NOy and NOx measurements by Tom Ryerson.
Computational and logistic assistance from the following individuals and
organizations is also gratefully appreciated: Carlie Coats (Baron AMS),
Ted Smith (Baron AMS), Don Olerud (Baron AMS), Jeff Vukovich (Baron AMS)
for emissions used by BAMS and the University of Iowa, Sophie Cousineau
(EC/MSC), L.-P. Crevier (EC/MSC), Hugo Landry (EC/SMC), Mike Moran
(S&T/EC), Paul Makar (S&T/EC), Balbir Pabla (S&T/EC), and the NOAA/FSL
High Performance Computing Facility. The U. S. Environmental Protection
Agency through its Office of Research and Development collaborated in
the research described here. It has been subjected to Agency review and
approved for publication.
NR 75
TC 30
Z9 30
U1 2
U2 22
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
EI 2169-8996
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD JUN 18
PY 2009
VL 114
AR D00F11
DI 10.1029/2008JD011697
PG 26
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 460KS
UT WOS:000267187200008
ER
PT J
AU Matott, LS
Babendreier, JE
Purucker, ST
AF Matott, L. Shawn
Babendreier, Justin E.
Purucker, S. Thomas
TI Evaluating uncertainty in integrated environmental models: A review of
concepts and tools
SO WATER RESOURCES RESEARCH
LA English
DT Review
ID RAINFALL-RUNOFF MODELS; GENERALIZED POLYNOMIAL CHAOS; WATER-QUALITY
MODELS; SENSITIVITY-ANALYSIS; RISK-ASSESSMENT; AUTOMATIC CALIBRATION;
GLOBAL OPTIMIZATION; RELIABILITY METHODS; HYDROLOGIC-MODELS;
DIFFERENTIAL-EQUATIONS
AB This paper reviews concepts for evaluating integrated environmental models and discusses a list of relevant software-based tools. A simplified taxonomy for sources of uncertainty and a glossary of key terms with "standard'' definitions are provided in the context of integrated approaches to environmental assessment. These constructs provide a reference point for cataloging 65 different model evaluation tools. Each tool is described briefly (in the auxiliary material) and is categorized for applicability across seven thematic model evaluation methods. Ratings for citation count and software availability are also provided, and a companion Web site containing download links for tool software is introduced. The paper concludes by reviewing strategies for tool interoperability and offers guidance for both practitioners and tool developers.
C1 [Matott, L. Shawn; Babendreier, Justin E.; Purucker, S. Thomas] US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Off Res & Dev, Athens, GA 30605 USA.
[Matott, L. Shawn] Univ Waterloo, Dept Civil & Environm Engn, Waterloo, ON N2L 3G1, Canada.
RP Matott, LS (reprint author), US EPA, Ecosyst Res Div, Natl Exposure Res Lab, Off Res & Dev, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM lsmatott@uwaterloo.ca; babendreier.justin@epa.gov; purucker.tom@epa.gov
NR 186
TC 83
Z9 83
U1 11
U2 78
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0043-1397
J9 WATER RESOUR RES
JI Water Resour. Res.
PD JUN 17
PY 2009
VL 45
AR W06421
DI 10.1029/2008WR007301
PG 14
WC Environmental Sciences; Limnology; Water Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA 460MZ
UT WOS:000267193100001
ER
PT J
AU Richardson, SD
AF Richardson, Susan D.
TI Water Analysis: Emerging Contaminants and Current Issues
SO ANALYTICAL CHEMISTRY
LA English
DT Review
ID TANDEM MASS-SPECTROMETRY; SOLID-PHASE EXTRACTION; DISINFECTION
BY-PRODUCTS; PERFORMANCE LIQUID-CHROMATOGRAPHY; PERSONAL-CARE PRODUCTS;
TIME-OF-FLIGHT; POLYBROMINATED DIPHENYL ETHERS; BROMINATED FLAME
RETARDANTS; ASSISTED EMULSIFICATION-MICROEXTRACTION;
NITROSODIMETHYLAMINE NDMA FORMATION
C1 US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
RP Richardson, SD (reprint author), US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
NR 250
TC 212
Z9 228
U1 16
U2 135
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
J9 ANAL CHEM
JI Anal. Chem.
PD JUN 15
PY 2009
VL 81
IS 12
BP 4645
EP 4677
DI 10.1021/ac9008012
PG 33
WC Chemistry, Analytical
SC Chemistry
GA 457XN
UT WOS:000266969700004
PM 19456142
ER
PT J
AU Pelaez, M
de la Cruz, AA
Stathatos, E
Falaras, P
Dionysiou, DD
AF Pelaez, Miguel
de la Cruz, Armah A.
Stathatos, Elias
Falaras, Polycarpos
Dionysiou, Dionysios D.
TI Visible light-activated N-F-codoped TiO2 nanoparticles for the
photocatalytic degradation of microcystin-LR in water
SO CATALYSIS TODAY
LA English
DT Article; Proceedings Paper
CT 5th European Meeting on Solar Chemistry and Photocatalysis
CY OCT 04-08, 2008
CL Palermo, ITALY
DE Visible light; Microcystin-LR; Titanium dioxide; Photocatalysis;
Fluorine doping; Nitrogen doping; Sol-gel method
ID NITROGEN-DOPED TIO2; FLUORINATED SURFACTANT; DRIVEN PHOTOCATALYSIS;
MESOPOROUS MATERIALS; FILMS; POWDERS; PEROXYMONOSULFATE; NANOCATALYST;
DESTRUCTION; SILICA
AB In this study, we developed nonmetal-doped TiO2 nanoparticles (N-F-TiO2) by a novel synthesis route employing a simple sol-gel method containing a nonionic fluorosurfactant as pore template material to tailor-design the structural properties of TiO2 and fluorine dopant as well as ethylenediamine as nitrogen source for the photocatalytic response towards visible light. The synthesized photocatalyst was characterized by XRD, UV-vis spectroscopy, XPS, HR-TEM, ESEM and porosimetry measurements. The resulting nanoparticles exhibited enhanced structural properties such as high surface area (141 m(2)/g), high porosity (49%), mesoporous structure (2-10 nm pore size) and low degree of agglomeration (1.07). A reduction in the effective band gap (2.75 eV) was observed compared with reference TiO2 (3.00 eV) due to the red-shift in the optical absorption spectrum of the nonmetal-doped TiO2 photocatalyst. We also focused on the environmental application of the prepared nanoparticles for the destruction of microcystin-LR (MC-LR) under visible light irradiation (lambda > 420 nm). Under acidic conditions (pH 3.0 +/- 0.1), the highest MC-LR degradation rate was achieved with N-F-TiO2. The electrostatic interactions between the toxin and the N-F-codoped TiO2 favored the photocatalytic degradation. Beneficial effects induced by codoping with nitrogen and fluorine are responsible for higher photocatalytic activity than TiO2 nanoparticles with only fluorine or nitrogen doping. Also, commercially available visible light-activated TiO2 showed lower degradation rate per unit surface area of the material. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Pelaez, Miguel; Dionysiou, Dionysios D.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
[de la Cruz, Armah A.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Stathatos, Elias] Inst Educ Technol, Dept Elect Engn, Patras 26334, Greece.
[Falaras, Polycarpos] NCSR Demokritos, Inst Phys Chem, Athens 15310, Greece.
RP Dionysiou, DD (reprint author), Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
EM dionysios.d.dionysiou@uc.edu
NR 37
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U1 7
U2 105
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-5861
J9 CATAL TODAY
JI Catal. Today
PD JUN 15
PY 2009
VL 144
IS 1-2
BP 19
EP 25
DI 10.1016/j.cattod.2008.12.022
PG 7
WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical
SC Chemistry; Engineering
GA 457YI
UT WOS:000266973600005
ER
PT J
AU Stout, DM
Bradham, KD
Egeghy, PP
Jones, PA
Croghan, CW
Ashley, PA
Pinzer, E
Friedman, W
Brinkman, MC
Nishioka, MG
Cox, DC
AF Stout, Daniel M., II
Bradham, Karen D.
Egeghy, Peter P.
Jones, Paul A.
Croghan, Carry W.
Ashley, Peter A.
Pinzer, Eugene
Friedman, Warren
Brinkman, Marielle C.
Nishioka, Marcia G.
Cox, David C.
TI American Healthy Homes Survey: A National Study of Residential
Pesticides Measured from Floor Wipes
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID EXPOSURES; CHILDREN
AB The U.S. Department of Housing and Urban Development in collaboration with the United States Environmental Protection Agency conducted a survey measuring lead, allergens, and insecticides in a randomly selected nationally representative sample of residential homes. Multistage sampling with clustering was used to select the 1131 homes of which a subset of 500 randomly selected homes included the collection of hard surface floor wipes. Samples were collected by trained field technicians between June 2005 and March 2006 using isopropanol wetted wipes. Samples were analyzed for a suite of 24 compounds which included insecticides in the organochlorine, organophosphate, pyrethroid and phenylpyrazole classes, and the insecticide synergist piperonyl butoxide. The most commonly detected were permethrin (89%), chlorpyrifos (78%), chlordane (64%, piperonyl butoxide (52%), cypermethrin (46%), and fipronil (40%). Mean and geometric mean (GM) concentrations varied widely among compounds, but were highest for trans-permethrin (mean 2.22 ng/cm(2) and GM 0.14 ng/cm(2)) and cypermethrin (mean 2.9 ng/cm(2) and GM 0.03 ng/cm(2)). Results show that most floors in occupied homes in the U.S. have measurable levels of insecticides that may serve as sources of exposure to occupants.
C1 [Stout, Daniel M., II; Bradham, Karen D.; Egeghy, Peter P.; Jones, Paul A.; Croghan, Carry W.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Ashley, Peter A.; Pinzer, Eugene; Friedman, Warren] US Dept Housing & Urban Dev, Off Healthy Homes & Lead Hazard Control, Washington, DC 20410 USA.
[Brinkman, Marielle C.; Nishioka, Marcia G.] Battelle Mem Inst, Columbus, OH 43201 USA.
[Cox, David C.] Quantech, Arlington, VA 22201 USA.
RP Stout, DM (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM stout.dan@epa.gov
OI Egeghy, Peter/0000-0002-1727-0766
NR 19
TC 67
Z9 67
U1 0
U2 17
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JUN 15
PY 2009
VL 43
IS 12
BP 4294
EP 4300
DI 10.1021/es8030243
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 457XF
UT WOS:000266968500014
PM 19603637
ER
PT J
AU Liu, GL
Cai, Y
Mao, YX
Scheidt, D
Kalla, P
Richards, J
Scinto, LJ
Tachiev, G
Roelant, D
Appleby, C
AF Liu, Guangliang
Cai, Yong
Mao, Yuxiang
Scheidt, Daniel
Kalla, Peter
Richards, Jennifer
Scinto, Leonard J.
Tachiev, Georgio
Roelant, David
Appleby, Charlie
TI Spatial Variability in Mercury Cycling and Relevant Biogeochemical
Controls in the Florida Everglades
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID DISSOLVED ORGANIC-MATTER; METHYLMERCURY CONCENTRATIONS; HUMIC
SUBSTANCES; GASEOUS MERCURY; SURFACE WATERS; FOOD WEBS; BINDING;
BIOACCUMULATION; BIOAVAILABILITY; METHYLATION
AB Spatial patterns in mercury cycling and bioaccumulation at the landscape level in the Everglades were investigated by collecting and analyzing multimedia samples for mercury species and biogeochemical characteristics from 228 randomly located stations. Higher total mercury (THg) in environmental compartments (surface water, soil, flocculent detrital material (floc), and periphyton) generally occurred in the northern and central Everglades, but higher THg in water and periphyton in the Everglades National Park was an exception. Multiple biogeochemical characteristics, such as surface water dissolved organic matter (DOC(SW)), pH, chloride, and compositional properties of solid compartments (soil and floc), were identified to be important factors controlling THg distribution. Methylmercury (MeHg) was also higher in the northern Everglades for water, soil, and floc, but not for periphyton. Higher mosquitofish THg and bioaccumulation factor were observed in the central and southern Everglades, partially in accordance with periphyton MeHg distribution, but not in the "hot spot" areas of water, soil, or floc MeHg. The discrepancy in mercury bioaccumulation and mercury distribution in environmental compartments suggests that in addition to MeHg production, biogeochemical controls that make MeHg available to aquatic organisms, such as DOC(SW) and compositional properties of soil and floc, are important in mercury bioaccumulation.
C1 [Liu, Guangliang; Cai, Yong; Mao, Yuxiang] Florida Int Univ, Dept Chem, Miami, FL 33199 USA.
[Liu, Guangliang; Cai, Yong; Scinto, Leonard J.] Florida Int Univ, SE Environm Res Ctr, Miami, FL 33199 USA.
[Scheidt, Daniel] US EPA, Water Management Div, Athens, GA 30605 USA.
[Kalla, Peter; Appleby, Charlie] US EPA, Sci & Ecosyst Support Div, Athens, GA 30605 USA.
[Richards, Jennifer] Florida Int Univ, Dept Biol Sci, Miami, FL 33199 USA.
[Tachiev, Georgio; Roelant, David] Florida Int Univ, Appl Res Ctr, Miami, FL 33174 USA.
RP Cai, Y (reprint author), Florida Int Univ, Dept Chem, Miami, FL 33199 USA.
EM cai@fiu.edu
RI Cai, Yong/K-9868-2015
OI Cai, Yong/0000-0002-2811-4638
FU U.S. EPA Region 4; National Park Service, Florida Department of
Environmental Protection (FDEP) [CA H5297-05-008]; U.S. Department of
Energy [DE-FG01-05EW07033]; Natural Science Foundation of China
FX This work was partially sponsored by U.S. EPA Region 4, the National
Park Service, Florida Department of Environmental Protection (FDEP) (CA
H5297-05-008), U.S. Department of Energy (DE-FG01-05EW07033), and the
Natural Science Foundation of China. We thank Damaris Hernandez, Sandra
Zapata, and Leonel Londono at FIU Mercury Laboratory (SERCMLAB), Tim
Fitzpatrick at FDEP, and Brenda Lasorsa at Battelle Marine Science
Laboratory for sample analysis. We thank Phyllis Meyer and Mel Parsons
at EPA Region 4 for sampling support. We greatly acknowledge three
anonymous reviewers for their valuable comments on the earlier version
of this paper. This is contribution No. 432 of Southeast Environmental
Research Center at FIU.
NR 44
TC 17
Z9 18
U1 1
U2 23
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JUN 15
PY 2009
VL 43
IS 12
BP 4361
EP 4366
DI 10.1021/es803665c
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 457XF
UT WOS:000266968500024
PM 19603647
ER
PT J
AU Gerke, TL
Scheckel, KG
Schock, MR
AF Gerke, Tammie L.
Scheckel, Kirk G.
Schock, Michael R.
TI Identification and Distribution of Vanadinite (Pb-5(V5+O4)(3)Cl in Lead
Pipe Corrosion By-Products
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID WATER DISTRIBUTION-SYSTEMS; DRINKING-WATER; HYDROXYAPATITE;
CHLOROPYROMORPHITE; PYROMORPHITE; ACCUMULATION; ADSORPTION; SPECIATION;
V(IV); V(V)
AB This study presents the first detailed look at vanadium (V) speciation in drinking water pipe corrosion scales. A pool of 34scale layers from 15 lead or lead-lined pipes representing eight different municipal drinking water distribution systems in the Northeastern and Midwestern portions of the United States were examined. Diverse synchrotron-based techniques, including bulk XANES (X-ray absorption near edge spectroscopy), mu-XANES, mu-XRD (X-ray diffraction), and mu-XRF (X-ray fluorescence) mapping were employed along with traditional powder XRD, SEM-EDXA (scanning electron microscopy-energy dispersive X-ray analysis), and ICP-OES (inductively coupled plasma-optical emission spectrometry) to evaluate vanadium speciation and distribution in these deposits. Vanadinite (Pb-5(VO4)(3)Cl) was positively identified, and occurred most frequently in the surface layers. Low V-tot in these waters is likely the limiting factor in the abundance of vanadinite in the pipe scales, along with the existence of divalent lead. The occurrence of V in these samples as a discrete mineral is important because it is formed in the presence of very low concentrations of V in the finished water, it provides a mechanism to concentrate mu g.L-1 amounts of V from the water to near-percent levels in the pipe scales, and the robustness of V accumulation and release in response to water chemistry changes is likely different than it would be with a sorption accumulation mechanism. Extrapolation from limited existing water chemistry data in this study provides an estimate of Delta G(f)degrees for vanadinite as approximately -3443 kJ,mol(-1), or less, leading to a log K-s0 value of approximately -86 for the reaction
Pb-5(VO4)(3)CI(s) reversible arrow {Pb2+}(5) + {VO43-} + {Cl-} in which {}denotes activity.
C1 [Scheckel, Kirk G.; Schock, Michael R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Gerke, Tammie L.] Univ Cincinnati, Dept Geol, Cincinnati, OH 45221 USA.
RP Schock, MR (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM Schock.Michael@epa.gov
RI Scheckel, Kirk/C-3082-2009
OI Scheckel, Kirk/0000-0001-9326-9241
NR 40
TC 24
Z9 24
U1 4
U2 16
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JUN 15
PY 2009
VL 43
IS 12
BP 4412
EP 4418
DI 10.1021/es900501t
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 457XF
UT WOS:000266968500032
PM 19603655
ER
PT J
AU D'Eon, JC
Crozier, PW
Furdui, VI
Reiner, EJ
Libelo, EL
Mabury, SA
AF D'Eon, Jessica C.
Crozier, Patrick W.
Furdui, Vasile I.
Reiner, Eric J.
Libelo, E. Laurence
Mabury, Scott A.
TI Observation of a Commercial Fluorinated Material, the Polyfluoroalkyl
Phosphoric Acid Diesters, in Human Sera, Wastewater Treatment Plant
Sludge, and Paper Fibers
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID FLUOROTELOMER ALCOHOL BIODEGRADATION; PERFLUORINATED CARBOXYLIC-ACIDS;
NHANES 1999-2000; NATIONAL-HEALTH; US POPULATION; HUMAN BLOOD; EXPOSURE;
PERFLUOROOCTANOATE; CHEMICALS; FOOD
AB Sources of human exposure to perfluorinated carboxylic acids (PFCAs) are not well-characterized. Polyfluoroalkyl phosphoric acids (PAPs) are fluorinated surfactants used in human food contact paper products. PAPs can migrate into food and food simulants, and their bioavailability and biotransformation into PFCAs has been demonstrated using a rat model. To characterize human exposure to PAP materials, we analyzed pooled human sera samples collected in 2004 and 2005 (n = 10) and 2008 (n = 10) from the midwestern United States for the 4:2 through 10:2 PAP diesters (diPAPs). The 2004 and 2005 sera samples contained 4.5 mu g/L total diPAPs, with the 6:2 diPAP dominating the congener profile at 1.9 +/- 0.4 mu g/L DiPAP concentrations observed in the 2004 and 2005 human sera samples were similar to those of the C8 to C11 PFCAs (0.13 +/- 0.01 to 4.2 +/- 0.3 mu g/L) monitored in the same samples. 6:2 diPAP was also consistently observed in the 2008 human sera samples at a mean concentration of 0.63 +/- 0.13 mu g/L. As diPAPs have been shown to degrade to PFCAs; in vivo, our observation of diPAPs in human sera may be a direct connection between the legacy of human PFCA contamination and PAPs commercial applications. Wastewater treatment plant (WWTP) sludge and paper fibers were analyzed for diPAPs as a proxy for human use and potential exposure to diPAPs. DiPAPs were observed in WWTP sludge at concentrations ranging from 47 +/- 22 to 200 +/- 130 ng/g, a range similar to perfluorooctane sulfonic acid (PFOS) (100 +/- 70 ng/g) and greater than the C8 to C11 PFCAs (1.6 +/- 0.6 to 0.17 +/- 0.10 ng/g) observed in the same samples. DiPAPs were observed in paper fiber extracts at concentrations ranging from 34 +/- 30 to 2200 +/- 400 ng/g. The high diPAP concentrations in WWTP sludge suggest PAP materials may be prevalent in our daily lives.
C1 [D'Eon, Jessica C.; Furdui, Vasile I.; Mabury, Scott A.] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada.
[Crozier, Patrick W.; Reiner, Eric J.] Ontario Minist Environm, Lab Serv Branch, Toronto, ON M9P 3V6, Canada.
[Libelo, E. Laurence] US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA.
RP Mabury, SA (reprint author), Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada.
EM smabury@chem.utoronto.ca
RI Furdui, Vasile/A-4916-2009;
OI Furdui, Vasile/0000-0003-2340-3614; Reiner, Eric /0000-0002-5349-2139
NR 38
TC 99
Z9 105
U1 7
U2 84
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JUN 15
PY 2009
VL 43
IS 12
BP 4589
EP 4594
DI 10.1021/es900100d
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 457XF
UT WOS:000266968500058
PM 19603681
ER
PT J
AU Volckens, J
Dailey, L
Walters, G
Devlin, RB
AF Volckens, John
Dailey, Lisa
Walters, Glenn
Devlin, Robert B.
TI Direct Particle-to-Cell Deposition of Coarse Ambient Particulate Matter
Increases the Production of Inflammatory Mediators from Cultured Human
Airway Epithelial Cells
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID IN-VITRO; ELECTROSTATIC PRECIPITATOR; AEROSOL-PARTICLES; EXPOSURE
SYSTEM; INTERFACE; TOXICITY; RELEASE; FINE
AB Exposure of cultured cells to particulate matter air pollution is usually accomplished by collecting particles on a solid matrix, extracting the particles from the matrix, suspending them in liquid, and applying the suspension to cells grown on plastic and submerged in medium. The objective of this work was to develop a more physiologically and environmentally relevant model of air pollutant deposition on cultures of human primary airway epithelial cells. We hypothesize that the toxicology of inhaled particulate matter depends strongly on both the particulate dispersion state and the mode of delivery to cells. Our exposure system employs a combination of unipolar charging and electrostatic force to deposit particles directly from the air onto cells grown at an air-liquid interface in a heated, humidified exposure chamber. Normal human bronchial epithelial cells exposed to concentrated, coarse ambient particulate matter in this system expressed increased levels of inflammatory biomarkers at 1 h following exposure and relative to controls exposed to particle-free air. More importantly, these effects are seen at particulate loadings that are 1-2 orders of magnitude lower than levels applied using traditional in vitro systems.
C1 [Volckens, John] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
[Dailey, Lisa; Devlin, Robert B.] US EPA, Clin Res Lab, Natl Hlth & Environm Effects Lab, Res Triangle Pk, NC 27711 USA.
[Walters, Glenn] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
RP Volckens, J (reprint author), Colorado State Univ, Dept Environm & Radiol Hlth Sci, 1681 Campus Delivery, Ft Collins, CO 80523 USA.
EM john.volckens@colostate.edu
FU NIEHS NIH HHS [5K25ES-014378, K25 ES014378, K25 ES014378-01A1]
NR 23
TC 40
Z9 40
U1 0
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JUN 15
PY 2009
VL 43
IS 12
BP 4595
EP 4599
DI 10.1021/es900698a
PG 5
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 457XF
UT WOS:000266968500059
PM 19603682
ER
PT J
AU Boese, BL
Kaldy, JE
Clinton, PJ
Eldridge, PM
Folger, CL
AF Boese, Bruce L.
Kaldy, James E.
Clinton, Patrick J.
Eldridge, Peter M.
Folger, Christina L.
TI Recolonization of intertidal Zostera marina L. (eelgrass) following
experimental shoot removal
SO JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY
LA English
DT Article
DE Intertidal; Physical disturbance; Recolonization; Zostera marina
ID THALASSIA-TESTUDINUM; SEAGRASS BEDS; COASTAL WATERS; NATIONAL-PARK;
SEED; RECRUITMENT; DISTURBANCE; ESTUARY; DEMOGRAPHY; DISPERSAL
AB The recovery of eelgrass (Zostera marina) from physical disturbances is understudied and no attention has been given to the likely differences in damage recovery rates between the continuous lower intertidal perennial meadows and higher intertidal eelgrass patches. In the present study, 4 m(2) plots were treated by removing all eelgrass shoots and followed over a 3 year period until they attained control (untreated) plot shoot densities. The number and types of shoots (vegetative, reproductive, and seedling) were counted semimonthly with comparisons made between experimental and control plots. In the second year of the study additional plots were denuded and sown with Z. marina seeds to evaluate the importance of seedlings in the recovery process. Our results suggest that recovery in both low and high intertidal plots was due exclusively to rhizome growth from adjacent perennial eelgrass. This recovery began immediately within the permanent eelgrass meadow and was complete within 24 months. Denuded transition zone patches took almost twice as long to recover to control densities. Natural seedling production appeared to play no part in recovery When larger numbers of seeds were planted into denuded plots in the winter, only a small portion of them produced seedlings in the spring and none appear to survive through the summer. These experimental eelgrass recovery rates were similar to recovery rates determined from aerial photographs of an eelgrass meadow damaged by a boat grounding near the study site. We suggest that transition zone perennial patches are more vulnerable to natural and anthropogenic disturbance events than lower intertidal eelgrass meadows. Published by Elsevier B.V.
C1 [Boese, Bruce L.; Kaldy, James E.; Clinton, Patrick J.; Eldridge, Peter M.; Folger, Christina L.] US EPA, Western Ecol Div, Newport, OR 97366 USA.
RP Boese, BL (reprint author), US EPA, Western Ecol Div, 2111 SE Marine Sci Ctr Dr, Newport, OR 97366 USA.
EM boese.bruce@epa.gov
FU U. S. Environmental Protection Agency
FX This information has been funded wholly by the U. S. Environmental
Protection Agency. It has been subjected to the Agency's peer and
administrative review, and it has been approved for publication as an
EPA document. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use. [SS]
NR 47
TC 17
Z9 17
U1 1
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-0981
J9 J EXP MAR BIOL ECOL
JI J. Exp. Mar. Biol. Ecol.
PD JUN 15
PY 2009
VL 374
IS 1
BP 69
EP 77
DI 10.1016/j.jembe.2009.04.011
PG 9
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 460GN
UT WOS:000267176300009
ER
PT J
AU Choi, H
Al-Abed, SR
AF Choi, Hyeok
Al-Abed, Souhail R.
TI PCB congener sorption to carbonaceous sediment components: Macroscopic
comparison and characterization of sorption kinetics and mechanism
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Polychlorinated biphenyls; Sorption; Carbonaceous component; Sediment;
2-chlorobiphenyl
ID SOOT-LIKE MATERIALS; BLACK CARBON; POLYCHLORINATED-BIPHENYLS;
ORGANIC-COMPOUNDS; ACTIVATED CARBON; PAH SPECIATION; ADSORPTION;
BIOAVAILABILITY; DECHLORINATION; CONTAMINANTS
AB Sorption of polychlorinated biphenyls (PCBs) to sediment is a key process in determining their mobility, bioavailability, and chemical decomposition in aquatic environments. In order to examine the validity of currently used interpretation approaches for PCBs sorption, comparative results on 2-chlorobiphenyl sorption to carbonaceous components in sediments (activated carbon, carbon black, coal. soot, graphite, flyash, wood) were macroscopically correlated with the structural, morphological, crystallographic, and compositional properties of the carbonaceous components. Since the Freundlich sorption constant, K(F) (L kg(-1)) spanned several orders of magnitude, ranging from log K(F) of 6.13-5.27 for activated carbon, 5.04 for carbon black, 3.83 for coal to 3.08 for wood, organic carbon partitioning approach should be More specifically categorized, considering the various forms, nature and origins of organic carbon in sediment. Sorption rate constants and fraction parameters, which were numerically defined from empirical kinetic model with fast and slow sorption fractions, were closely related to the physicochemical properties of the carbonaceous components. Sorption interpretation approaches with a specific property and viewpoint, such as organic carbon partitioning, soot carbon distribution, or surface area correlation, did not properly explain the overall results oil sorption capacity, fast and slow sorption kinetics, and partitioning coefficient. It is also important to emphasize the heterogeneous nature of sediment and the difficulties of encompassing the partitioning among its carbonaceous components. Published by Elsevier B.V.
C1 [Choi, Hyeok; Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Al-Abed, SR (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM al-abed.souhail@epa.gov
FU National Risk Management Research Laboratory of U.S. EPA, Cincinnati,
Ohio; U.S. Environmental Protection Agency
FX This research was funded and conducted by the National Risk Management
Research Laboratory of U.S. EPA, Cincinnati, Ohio. This paper has not
been subjected to internal policy review of the U.S. Environmental
Protection Agency. Therefore, the research results do not necessarily
reflect the views of the agency or its policy. Mention of trade names
and commercial products does not Constitute endorsement or
recommendation for use. The authors recognize the support of Mr. Eric
Graybill of Pegasus Technical Services, Inc. for sample preparation and
analysis using GC/MS and Dr. QiLIjing Yang at University of Cincinnati
for sample characterization. The authors greatly appreciate Norit
Americas Inc. for their generous donation of the activated carbon.
NR 28
TC 13
Z9 18
U1 4
U2 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD JUN 15
PY 2009
VL 165
IS 1-3
BP 860
EP 866
DI 10.1016/j.jhazmat.2008.10.100
PG 7
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 446KY
UT WOS:000266121700113
PM 19059706
ER
PT J
AU Lytle, DA
White, C
Nadagouda, MN
Worrall, A
AF Lytle, Darren A.
White, Colin
Nadagouda, Mallikarjuna N.
Worrall, Adam
TI Crystal and morphological phase transformation of Pb(II) to Pb(IV) in
chlorinated water
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Morphology; PbO(2); X-ray diffraction; Crystal structure; Drinking water
ID NATURAL ORGANIC-MATTER; DRINKING-WATER; LEAD; REDUCTION; SOLUBILITY;
CARBONATE
AB Herein, we show an important transformation of Pb(II) to Pb(IV) in chlorinated water under laboratory conditions. The study results will give an insight toward understanding how corrosion by-products on lead materials found in drinking water distribution systems develop and breakdown with time. The experiments were conducted to elucidate the morphology of lead (IV) oxide mineral transformation from hydrocerussite and its relationship to color change over a period of time. Scanning electron microscopy and transmission electron microscopy were used to describe the surface morphology, shape and size of lead solids. X-ray diffraction (XRD) analysis was performed to determine the mineral structure of lead solids. Solids analysis results were compared over a 14-day period of time to define changes in the crystal structure and morphology of lead solids. XRD analysis results of freshly synthesized lead solids showed that hydrocerussite, [Pb(3)(CO(3))(2)(OH)(2)], was the only lead mineral present. After 14 days, a mixture of cerussite (PbCO(3)) and alpha-PbO(2) and beta-PbO(2) was present. Lead precipitates, i.e. hydrocerussite changed color from white to reddish brown confirming a transformation of the lead phase with time. This was correlated to a change in morphology from flower shaped crystals to hexagonal bars and submicron particles. Published by Elsevier B.V.
C1 [Lytle, Darren A.; White, Colin] US EPA, ORD, NRMRL, WSWRD,TTEB, Cincinnati, OH 45268 USA.
[Nadagouda, Mallikarjuna N.] Pegasus Tech Serv, Cincinnati, OH 45219 USA.
[Worrall, Adam] Univ Cincinnati, Dept Chem & Mat Engn, Cincinnati, OH 45221 USA.
RP Lytle, DA (reprint author), US EPA, ORD, NRMRL, WSWRD,TTEB, Cincinnati, OH 45268 USA.
EM lytle.darren@epa.gov; white.colin@epa.gov;
Nadagouda.mallikarjuna@epa.gov; worralad@email.uc.edu
NR 21
TC 6
Z9 6
U1 0
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD JUN 15
PY 2009
VL 165
IS 1-3
BP 1234
EP 1238
DI 10.1016/j.jhazmat.2008.10.058
PG 5
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 446KY
UT WOS:000266121700168
PM 19081184
ER
PT J
AU Stehman, SV
Wickham, JD
Fattorini, L
Wade, TD
Baffetta, F
Smith, JH
AF Stehman, Stephen V.
Wickham, James D.
Fattorini, Lorenzo
Wade, Timothy D.
Baffetta, Federica
Smith, Jonathan H.
TI Estimating accuracy of land-cover composition from two-stage cluster
sampling
SO REMOTE SENSING OF ENVIRONMENT
LA English
DT Article
DE Sampling design; Horvitz-Thompson estimation; Multiple objectives
ID CONTERMINOUS UNITED-STATES; THEMATIC MAPPER DATA; MID-ATLANTIC REGION;
USA COAST RANGE; CLASSIFICATION ACCURACY; SATELLITE DATA; DATA SETS;
MAPS; AREA; VALIDATION
AB Land-cover maps are often used to compute land-cover composition (i.e., the proportion or percent of area covered by each class), for each unit in a spatial partition of the region mapped. We derive design-based estimators of mean deviation (MD), mean absolute deviation (MAD), root mean square error (RMSE), and correlation (CORR) to quantify accuracy of land-cover composition for a general two-stage cluster sampling design, and for the special case of simple random sampling without replacement (SRSWOR) at each stage. The bias of the estimators for the two-stage SRSWOR design is evaluated via a simulation study. The estimators of RMSE and CORR have small bias except when sample size is small and the land-cover class is rare. The estimator of MAD is biased for both rare and common land-cover classes except when sample size is large. A general recommendation is that rare land-cover classes require large sample sizes to ensure that the accuracy estimators have small bias. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Stehman, Stephen V.] SUNY Coll Environm Sci & Forestry, Syracuse, NY 13210 USA.
[Wickham, James D.; Wade, Timothy D.] US EPA, Res Triangle Pk, NC 27711 USA.
[Fattorini, Lorenzo] Univ Siena, Dipartimento Metodi Quantitat, I-53100 Siena, Italy.
[Baffetta, Federica] Univ Florence, Dipartimento Stat G Parenti, Florence, Italy.
[Smith, Jonathan H.] US Geol Survey, Geog Anal & Monitoring Program, Reston, VA 22092 USA.
RP Stehman, SV (reprint author), SUNY Coll Environm Sci & Forestry, 320 Bray Hall,1 Forestry Dr, Syracuse, NY 13210 USA.
EM svstehma@syr.edu
NR 49
TC 11
Z9 11
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0034-4257
J9 REMOTE SENS ENVIRON
JI Remote Sens. Environ.
PD JUN 15
PY 2009
VL 113
IS 6
BP 1236
EP 1249
DI 10.1016/j.rse.2009.02.011
PG 14
WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic
Technology
SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science &
Photographic Technology
GA 446LP
UT WOS:000266123400011
ER
PT J
AU Elleman, RA
Covert, DS
AF Elleman, Robert A.
Covert, David S.
TI Aerosol size distribution modeling with the Community Multiscale Air
Quality modeling system in the Pacific Northwest: 2. Parameterizations
for ternary nucleation and nucleation mode processes
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
ID ATMOSPHERIC SULFURIC-ACID; PARTICLE FORMATION EVENTS; MARINE
BOUNDARY-LAYER; LOWER FRASER VALLEY; CHEMICAL-COMPOSITION; MOLECULAR
CLUSTERS; REGIONAL AEROSOLS; WATER NUCLEATION; ORGANIC VAPORS;
GROWTH-RATES
AB In order to test Community Multiscale Air Quality (CMAQ) model performance for ultrafine particle concentrations in the Pacific Northwest, CMAQ v4.4 was modified for ternary NH3-H2SO4-H2O nucleation and for atmospheric processing of ultrafine particles. Sulfuric acid from sulfur dioxide oxidation is iteratively partitioned into gaseous sulfuric acid, newly condensed aerosol sulfate, and aerosol sulfuric acid contained in new 1 nm particles. Freshly nucleated particles are either coagulated to larger particles or grown by sulfuric acid condensation to 10 nm at which point they are included in CMAQ's existing Aitken mode. Multiple nucleation parameterizations were implemented into CMAQ, and one other was investigated in a sensitivity analysis. For a case study in the Pacific Northwest where aerosol number concentration and size distributions were measured, standard binary nucleation in CMAQ produces nearly no particles for this case study. Ternary nucleation can produce millions of 1 nm particles per cm 3, but few of these particles survive coagulation loss and grow to 10 nm and into the Aitken mode. There are occasions when the additions to CMAQ increase the number of particles to within an order of magnitude of observations, but it is more common for number concentrations to remain underpredicted by, on average, one order of magnitude. Significant particle nucleation in CMAQ successfully produces a distinct Aitken and accumulation mode and an Aitken mode that is more prominent than the accumulation mode, although errors in the size distribution remain. A more recent ternary nucleation scheme including ammonium bisulfate clusters does not nucleate an appreciable number of particles.
C1 [Elleman, Robert A.; Covert, David S.] Univ Washington, Dept Atmospher Sci, Seattle, WA 98195 USA.
RP Elleman, RA (reprint author), US EPA, 1200 6th Ave,Suite 900,OEA-095, Seattle, WA 98101 USA.
EM elleman.robert@epa.gov
FU Northwest Research Center for Particulate Air Pollution and Health
[R827355]; NSF [ATM0337853]
FX This work was supported by the Northwest Research Center for Particulate
Air Pollution and Health ( U. S. EPA grant R827355), NW-AIRQUEST
consortium of air quality agencies in the Pacific Northwest, U. S. EPA
Region 10 in Seattle, and NSF grant ATM0337853. We thank Jeff Arnold of
the U. S. EPA, Cliff Mass of the University of Washington, and Tim
Larson of the University of Washington for helpful suggestions and
comments. We also thank the Laboratory for Atmospheric Research at
Washington State University for technical and computing assistance. We
gratefully acknowledge the Pacific Northwest National Laboratory,
Environment Canada, Washington Department of Ecology, Oregon Department
of Environmental Quality, and IMPROVE program for use of field
NR 80
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Z9 9
U1 2
U2 11
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
EI 2169-8996
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD JUN 11
PY 2009
VL 114
AR D11207
DI 10.1029/2009JD012187
PG 16
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 458FV
UT WOS:000267001600001
ER
PT J
AU Elleman, RA
Covert, DS
AF Elleman, Robert A.
Covert, David S.
TI Aerosol size distribution modeling with the Community Multiscale Air
Quality modeling system in the Pacific Northwest: 1. Model comparison to
observations
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
ID LOWER FRASER VALLEY; MESOSCALE METEOROLOGICAL MODEL; AMBIENT PARTICULATE
MATTER; NONLOCAL CLOSURE-MODEL; ULTRAFINE PARTICLES; BOUNDARY-LAYER;
PERFORMANCE EVALUATION; MAJOR HIGHWAY; POLLUTION; CMAQ
AB This paper evaluates aerosol number and mass concentrations from the Community Multiscale Air Quality (CMAQ) modeling system at the 4 km scale against detailed airborne and surface measurements from the coordinated Pacific Northwest 2001 and Pacific 2001 field campaigns. Several investigators have tested CMAQ's prediction of PM2.5 mass, but relatively little attention has been paid to its representation of other subranges of the particulate size distribution. In addition, few have examined CMAQ aerosol performance in the unique Pacific Northwest emission and meteorological conditions. Airborne measurements show an underprediction of aerosol number by a factor of 10-100, especially in the Aitken mode (i.e., ultrafine, < 100 nm diameter). This result cannot simply be explained by errors in gas-phase constituents. Errors in modeled ozone, NO, NOy, and SO2 exist, but the aerosol number underprediction is relatively constant while the gas-phase errors fluctuate in time and location. For the period of aircraft measurements, the surface PM2.5 mass normalized mean bias is 2%, -33%, and -38%. Speciated aerosol measurements reveal a large but intermittent positive bias in aerosol nitrate and organic mass. Errors in aerosol mass and composition are not consistent or large enough to explain the negative bias factor of 5 - 10 in accumulation mode particle number concentration and of 10 - 100 in total particle number concentration. The few other studies of CMAQ size distributions have found similar performance, the root of which has many potential causes and is worthy of future investigation.
C1 [Elleman, Robert A.; Covert, David S.] Univ Washington, Dept Atmospher Sci, Seattle, WA 98195 USA.
RP Elleman, RA (reprint author), US EPA, 1200 6th Ave,Suite 900,OEA-095, Seattle, WA 98101 USA.
EM elleman.robert@epa.gov
FU Northwest Research Center for Particulate Air Pollution and Health
[R827355]; NSF [ATM0337853]
FX This work was supported by the Northwest Research Center for Particulate
Air Pollution and Health (U.S. EPA grant R827355), NW-AIRQUEST
consortium of air quality agencies in the Pacific Northwest, U.S. EPA
Region 10 in Seattle, and NSF grant ATM0337853. We thank Jeff Arnold of
the U.S. EPA, Cliff Mass of the University of Washington, and Tim Larson
of the University of Washington for helpful suggestions and comments. We
also thank the Laboratory for Atmospheric Research at Washington State
University for technical and computing assistance. We gratefully
acknowledge the Pacific Northwest National Laboratory, Environment
Canada, Washington Department of Ecology, Oregon Department of
Environmental Quality, and IMPROVE program for use of field data.
NR 60
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Z9 14
U1 0
U2 10
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
EI 2169-8996
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD JUN 10
PY 2009
VL 114
AR D11206
DI 10.1029/2008JD010791
PG 16
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 458FU
UT WOS:000267001500001
ER
PT J
AU Templeton, AR
Kramer, MG
Jarvis, J
Kowalski, J
Gange, S
Schneider, MF
Shao, QJ
Zhang, GW
Yeh, MF
Tsai, HL
Zhang, H
Markham, RB
AF Templeton, Alan R.
Kramer, Melissa G.
Jarvis, Joseph
Kowalski, Jeanne
Gange, Stephen
Schneider, Michael F.
Shao, Qiujia
Zhang, Guang Wen
Yeh, Mei-Fen
Tsai, Hua-Ling
Zhang, Hong
Markham, Richard B.
TI Multiple-infection and recombination in HIV-1 within a longitudinal
cohort of women
SO RETROVIROLOGY
LA English
DT Article
ID VIRUS TYPE-1 SUPERINFECTION; PHYLOGENETIC INFERENCE; EVOLUTION;
INDIVIDUALS; SELECTION; DYNAMICS; PATTERNS; MODEL; GENE
AB Background: Recombination between strains of HIV-1 only occurs in individuals with multiple infections, and the incidence of recombinant forms implies that multiple infection is common. Most direct studies indicate that multiple infection is rare. We determined the rate of multiple infection in a longitudinal study of 58 HIV-1 positive participants from The Women's Interagency HIV Study with a richer sampling design than previous direct studies, and we investigated the role of recombination and sampling design on estimating the multiple infection rate.
Results: 40% of our sample had multiple HIV-1 infections. This rate of multiple infection is statistically consistent with previous studies once differences in sampling design are taken into account. Injection drug use significantly increased the incidence of multiple infections. In general there was rapid elimination of secondary strains to undetectable levels, but in 3 cases a superinfecting strain displaced the initial infecting strain and in two cases the strains coexisted throughout the study. All but one secondary strain was detected as an inter- and/or intra-genic recombinant. Injection drug use significantly increased the rate of observed recombinants.
Conclusion: Our multiple infection rate is consistent with rates estimated from the frequency of recombinant forms of HIV-1. The fact that our results are also consistent with previous direct studies that had reported a much lower rate illustrates the critical role of sampling design in estimating this rate. Multiple infection and recombination significantly add to the genetic diversity of HIV-1 and its evolutionary potential, and injection drug use significantly increases both.
C1 [Templeton, Alan R.] Washington Univ, Dept Biol, St Louis, MO 63130 USA.
[Kramer, Melissa G.; Jarvis, Joseph] Washington Univ, Div Biol & Biomed Sci, St Louis, MO 63130 USA.
[Kramer, Melissa G.] US EPA, Washington, DC 20460 USA.
[Kowalski, Jeanne; Yeh, Mei-Fen; Tsai, Hua-Ling] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA.
[Gange, Stephen; Schneider, Michael F.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
[Shao, Qiujia; Zhang, Guang Wen; Zhang, Hong; Markham, Richard B.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA.
RP Templeton, AR (reprint author), Washington Univ, Dept Biol, Campus Box 1137, St Louis, MO 63130 USA.
EM temple_a@wustl.edu; kramer.melissa@epa.gov; jpjarvis@artsci.wustl.edu;
jkowals1@jhmi.edu; sgange@jhsph.edu; mschneid@jhsph.edu; qshao@mmc.edu;
gwzhang@jhmi.edu; mxy02@hotmail.com; htsai4@jhmi.edu; hzhang@jhsph.edu;
rmarkham@jhsph.edu
RI Templeton, Alan/F-5963-2011;
OI Gange, Stephen/0000-0001-7842-512X
FU NIH [GM60730, GM65509]; National Cancer Institute; National Institute of
Child Health & Human Development; National Institute on Drug Abuse
[U01-AI-35004, U01-AI-31834, U01-AI-34994, AI-34989, U01-HD-32632,
U01-AI-34993, U01-AI-42590]; National Institute of Allergy and
Infectious Diseases [R01-DA/AI13347]; National Institute of General
Medical Sciences [R01-GM60730]
FX This work was supported by NIH grants GM60730 and GM65509. Plasma
specimens used as the source for data in this manuscript were collected
by the Women's Interagency HIV Study (WIHS) Collaborative Study Group
with centers (Principal Investigators) at New York City/Bronx Consortium
(Kathryn Anastos); Brooklyn, NY (Howard Minkoff); Washington DC
Metropolitan Consortium (Mary Young); The Connie Wofsy Study Consortium
of Northern California (Ruth Greenblatt, Herminia Palacio); Los Angeles
County/Southern California Consortium (Alexandra Levine); Chicago
Consortium (Mardge Cohen); Data Coordinating Center (Stephen Gange). The
WIHS is funded by the National Institute of Allergy and Infectious
Diseases, with supplemental funding from the National Cancer Institute,
the National Institute of Child Health & Human Development, and the
National Institute on Drug Abuse (U01-AI-35004, U01-AI-31834,
U01-AI-34994, AI-34989, U01-HD-32632, U01-AI-34993, U01-AI-42590). This
research was also funded by grants from the National Institute on Drug
Abuse, the National Institute of Allergy and Infectious Diseases
R01-DA/AI13347 and the National Institute of General Medical Sciences
R01-GM60730. We thank two anonymous reviewers for their excellent
suggestions on an earlier draft of this work.
NR 35
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U1 0
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T
4LB, ENGLAND
SN 1742-4690
J9 RETROVIROLOGY
JI Retrovirology
PD JUN 3
PY 2009
VL 6
AR 54
DI 10.1186/1742-4690-6-54
PG 12
WC Virology
SC Virology
GA 463KM
UT WOS:000267430800001
PM 19493346
ER
PT J
AU Carleton, JN
Montas, HJ
AF Carleton, James N.
Montas, Hubert J.
TI Reactive transport in stratified flow fields with idealized
heterogeneity
SO ADVANCES IN WATER RESOURCES
LA English
DT Article
DE Analytical solution; Dispersion; Velocity profile; Reactive transport;
Wetlands
ID SOLUTE TRANSPORT; TREATMENT WETLANDS; DISPERSION; MEDIA
AB A two-dimensional equation governing the steady state spatial concentration distribution of a reactive constituent within a heterogeneous advective-dispersive flow field is solved analytically. The solution which is developed for the case of a single point source can be generalized to represent analogous situations with any number of separate point sources. A limiting case of special interest has a line source of constant concentration spanning the domain's upstream boundary. The work has relevance for improving understanding of reactive transport within various kinds of advection-dominated natural or engineered environments including rivers and streams, and bioreactors such as treatment wetlands. Simulations are used to examine quantitatively the impact that transverse dispersion (deviations from purely stochastic-convective flow) can have on mean concentration decline in the direction of flow. Results support the contention that transverse mixing serves to enhance the overall rate of reaction in such systems. Published by Elsevier Ltd.
C1 [Carleton, James N.] US EPA, Off Sci & Technol, Off Water, Washington, DC 20460 USA.
[Montas, Hubert J.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.
RP Carleton, JN (reprint author), US EPA, Off Sci & Technol, Off Water, Mail Code 4305T,1200 Penn Ave NW, Washington, DC 20460 USA.
EM carleton.jim@epa.gov; montas@umd.edu
NR 26
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Z9 4
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0309-1708
EI 1872-9657
J9 ADV WATER RESOUR
JI Adv. Water Resour.
PD JUN
PY 2009
VL 32
IS 6
BP 906
EP 915
DI 10.1016/j.advwatres.2009.03.001
PG 10
WC Water Resources
SC Water Resources
GA 456ZW
UT WOS:000266895000010
ER
PT J
AU Ippolito, JA
Barbarick, KA
Brobst, RB
AF Ippolito, J. A.
Barbarick, K. A.
Brobst, R. B.
TI Fate of biosolids Cu and Zn in a semi-arid grassland
SO AGRICULTURE ECOSYSTEMS & ENVIRONMENT
LA English
DT Article
DE 4 M HNO(3) extraction; Biosolids-borne metals; Mobility; Semi-arid
grassland; Sequential extraction
ID SLUDGE-TREATED SOILS; CLAY LOAM SOIL; SEWAGE-SLUDGE; HEAVY-METALS;
TRACE-ELEMENTS; SEQUENTIAL EXTRACTION; AGRICULTURAL SOILS;
BIOAVAILABILITY; SPECIATION; CHEMISTRY
AB Biosolids land application applies varying trace metal amounts to Soils. Measuring total soil metals is typically performed to ensure environmental protection, Yet this technique does not quantify Which Soil phases play important metal release or attenuation roles. We assessed the distribution of biosolids-borne Cu and Zn associated with soluble/exchangeable, specifically adsorbed/carbonate-bound,,amorphous and crystalline Mn/Fe oxyhydroxide-bound, residual organic, and residual inorganic phases. Biosolids Were surface-applied (no incorporation) to experimental plots, at the Meadow Springs Ranch (40 53'46 '' N, 104 52'28 '' W) which is owned by the city of Fort Collins, CO, USA, in 1991 at rates of 0, 2.5, 5, 10, 2 1, and 30 Mg ha(-1). Plots were split in half in 2002, with one-half receiving biosolids at rates identical to 1991 rates. In 2003, 0-8, 8-15, and 15-30-cm soil depths were collected and subjected to 4 M HNO(3) digestion and Sequential fractionation. The 4 M HNO(3) extraction Suggested downward Cu transport, while Zn was immobilized ill the Soil Surface. The sequential extraction procedure, more sensitive to changes in soil metal Pools, Suggested that repeated biosolids application did not affect vertical Zn movement, but did increase the downward transport potential of organically complexed Cu. In the given time, organically complexed Cu was likely mineralized and subsequently associated with soil mineral oxide phases. Because bioavailability of Cu is associated with dissolved phases, and soluble/exchangeable Cu concentrations were below detection limits in the Subsoil, a reduction in environmental quality should be minimal. Still, we advocate that On coarse-textured semi-arid soils, biosolids application rates Should match the plant N needs to avoid potential downward trace metal transport. Published by Elsevier B.V.
C1 [Barbarick, K. A.] Colorado State Univ, Dept Soil & Crop Sci, Ft Collins, CO 80523 USA.
[Brobst, R. B.] US EPA, Denver, CO 80202 USA.
RP Ippolito, JA (reprint author), ARS, USDA, NWISRL, 3793 N 3600 E, Kimberly, ID 83341 USA.
EM jim.ippolito@ars.usda.gov
RI Barbarick, Kenneth/B-7974-2013
OI Barbarick, Kenneth/0000-0002-8779-0740
FU USEPA [CP988928-01]
FX The USDA-ARS and Colorado State University gratefully acknowledges USEPA
Region 8 (Grant #CP988928-01) for its financial, technical, and
administrative assistance in funding and managing the project through
which this information was discovered. We additionally thank the City of
Fort Collins, Colorado for their continued support of this project.
NR 50
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Z9 7
U1 1
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-8809
J9 AGR ECOSYST ENVIRON
JI Agric. Ecosyst. Environ.
PD JUN
PY 2009
VL 131
IS 3-4
BP 325
EP 332
DI 10.1016/j.agee.2009.02.013
PG 8
WC Agriculture, Multidisciplinary; Ecology; Environmental Sciences
SC Agriculture; Environmental Sciences & Ecology
GA 438LK
UT WOS:000265556700025
ER
PT J
AU Hubbell, BJ
Fann, N
Levy, JI
AF Hubbell, Bryan J.
Fann, Neal
Levy, Jonathan I.
TI Methodological considerations in developing local-scale health impact
assessments: balancing national, regional, and local data
SO AIR QUALITY ATMOSPHERE AND HEALTH
LA English
DT Article
DE Health impact assessment; Baseline incidence rate; BenMAP;
Concentration-response function; Health impact function; Air quality
modeling
AB National-scale health impact assessments (HIAs) have been conducted for many years and have become reasonably systematized. Recently, there has been growing interest in utilizing HIA methods at local scales, in the context of Environmental Public Health Tracking and in other settings. This paper investigates the data and analytical challenges to estimating the incidence of health effects associated with changes in air pollution concentrations at the local scale, focusing on ozone and fine particulate matter. Although it could be argued that the local-scale HIA is simply a more geographically discrete version of the national-scale assessment and, therefore, has similar challenges, in practice, many key inputs in national-scale assessments are assumed to be spatially uniform or vary only at coarse geographic resolution. For a nationalscale assessment, this assumption may not contribute appreciable bias, but the bias could be significant for any individual location. Thus, local-scale assessments require more geographically resolved air quality data, concentration-response (C-R) functions, and baseline incidence rates than are often used. However, comprehensive local data may not be available, may be incomplete, or may be time-intensive and resource-intensive to develop, especially for C-R functions for which small-scale epidemiological studies will often be underpowered. Given this context, this paper considers how best to develop credible local-scale HIAs, identifying factors that contribute to variability across geographic areas, study designs, and time periods. This paper also describes which key sources of analytical uncertainty change as the scope shifts from the national to the local scale. These challenges notwithstanding, the paper concludes that a well-designed local-scale HIA, following key principles and recommendations, can be both informative and defensible.
C1 [Hubbell, Bryan J.; Fann, Neal] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Levy, Jonathan I.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
RP Fann, N (reprint author), US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
EM Fann.neal@epa.gov
OI Levy, Jonathan/0000-0002-1116-4006; Fann, Neal/0000-0002-6724-8575;
Hubbell, Bryan/0000-0002-7963-3438
NR 36
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Z9 30
U1 2
U2 16
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1873-9318
J9 AIR QUAL ATMOS HLTH
JI Air Qual. Atmos. Health
PD JUN
PY 2009
VL 2
IS 2
BP 99
EP 110
DI 10.1007/s11869-009-0037-z
PG 12
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA V25HR
UT WOS:000208469600004
ER
PT J
AU Xu, Q
Parks, CG
Deroo, LA
Cawthon, RM
Sandler, DP
Chen, HL
AF Xu, Qun
Parks, Christine G.
DeRoo, Lisa A.
Cawthon, Richard M.
Sandler, Dale P.
Chen, Honglei
TI Multivitamin use and telomere length in women
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID INTRACELLULAR OXIDATIVE-STRESS; PREDISPOSITION FACTOR;
CIGARETTE-SMOKING; CHRONIC DISEASE; CANCER RISK; VITAMIN-C; HEALTH;
MORTALITY; QUESTIONNAIRE; HOMOCYSTEINE
AB Background: Telomere length may be a marker of biological aging. Multivitamin supplements represent a major source of micronutrients, which may affect telomere length by modulating oxidative stress and chronic inflammation.
Objective: The objective was to examine whether multivitamin use is associated with longer telomeres in women.
Design: We performed a cross-sectional analysis of data from 586 early participants (age 35-74 y) in the Sister Study. Multivitamin use and nutrient intakes were assessed with a 146-item food-frequency questionnaire, and relative telomere length of leukocyte DNA was measured by quantitative polymerase chain reaction.
Results: After age and other potential confounders were adjusted for, multivitamin use was associated with longer telomeres. Compared with nonusers, the relative telomere length of leukocyte DNA was on average 5.1% longer among daily multivitamin users (P for trend = 0.002). In the analysis of micronutrients, higher intakes of vitamins C and E from foods were each associated with longer telomeres, even after adjustment for multivitamin use. Furthermore, intakes of both nutrients were associated with telomere length among women who did not take multivitamins.
Conclusion: This study provides the first epidemiologic evidence that multivitamin use is associated with longer telomere length among women. Am J Clin Nutr 2009; 89: 1857-63.
C1 [Chen, Honglei] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Res Triangle Pk, NC 27709 USA.
[Cawthon, Richard M.] Univ Utah, Dept Human Genet, Salt Lake City, UT USA.
RP Chen, HL (reprint author), Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, 111 TW Alexander Dr,POB 12233,Mail Drop A3-05, Res Triangle Pk, NC 27709 USA.
EM chenh2@niehs.nih.gov
OI Parks, Christine/0000-0002-5734-3456; Sandler, Dale/0000-0002-6776-0018;
Chen, Honglei/0000-0003-3446-7779
FU NIH, National Institute of Environmental Health Sciences [Z01ES044005,
Z01ES101986]; Department of Defense Breast Cancer Research Concept Award
[BC045286]
FX Supported by the Intramural Research Program of the NIH, National
Institute of Environmental Health Sciences (Z01ES044005 AND
Z01ES101986), and the Department of Defense Breast Cancer Research
Concept Award (BC045286).
NR 38
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U1 1
U2 21
PU AMER SOC CLINICAL NUTRITION
PI BETHESDA
PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998
USA
SN 0002-9165
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JUN 1
PY 2009
VL 89
IS 6
BP 1857
EP 1863
DI 10.3945/ajcn.2008.26986
PG 7
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 448EI
UT WOS:000266245500021
PM 19279081
ER
PT J
AU Madson, JG
Lynch, DT
Svoboda, J
Ophardt, R
Yanagida, J
Putta, SK
Bowles, A
Trempus, CS
Tennant, RW
Hansen, LA
AF Madson, Justin G.
Lynch, David T.
Svoboda, Jessica
Ophardt, Rebecca
Yanagida, Jodi
Putta, Sumanth K.
Bowles, Andrew
Trempus, Carol S.
Tennant, Raymond W.
Hansen, Laura A.
TI Erbb2 Suppresses DNA Damage-Induced Checkpoint Activation and UV-Induced
Mouse Skin Tumorigenesis
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID GROWTH-FACTOR-RECEPTOR; ULTRAVIOLET-IRRADIATION; HUMAN KERATINOCYTES;
HUMAN CDC25A; CELL-CYCLE; PATHWAY; CHK1; PHOSPHORYLATION; PROLIFERATION;
INHIBITION
AB The Erbb2 receptor is activated by UV irradiation, the primary cause of non-melanoma skin cancer. We hypothesized that Erbb2 activation contributes to UV-induced skin tumorigenesis by suppressing cell cycle arrest. Consistent with this hypothesis, inhibition of Erbb2 in v-ras(Ha) transgenic mice before UV exposure resulted in both 56% fewer skin tumors and tumors that were 70% smaller. Inhibition of the UV-induced activation of Erbb2 also resulted in milder epidermal hyperplasia, S-phase accumulation, and decreased levels of the cell cycle regulator Cdc25a, suggesting altered cell cycle regulation on inhibition of Erbb2. Further investigation using inhibition or genetic deletion of Erbb2 in vitro revealed reduced Cdc25a levels and increased S-phase arrest in UV-irradiated cells lacking Erbb2 activity. Ectopic expression of Cdc25a prevented UV-induced S-phase arrest in keratinocytes lacking Erbb2 activity, demonstrating that maintenance of Cdc25a by Erbb2 suppresses cell cycle arrest. Examination of checkpoint pathway activation upstream of Cdc25a revealed Erbb2 activation did not alter Ataxia Telangiectasia and Rad3-related/Ataxia Telangiectasia Mutated activity but increased inhibitory phosphorylation of Chk1-Ser(280). Since Akt phosphorylates; Chk1-Ser(280), the effect of Erbb2 on phosphatidyl inositol-3-kinase (PI3K)/Akt signaling during UV-induced cell cycle arrest was determined. Erbb2 ablation reduced the UV-induced activation of PI3K while inhibition of PI3K/Akt increased UV-induced S-phase arrest. Thus, UV-induced Erbb2 activation increases skin tumorigenesis through inhibitory phosphorylation of Chk1, Cdc25a maintenance, and suppression of S-phase arrest via a PI3K/Akt-dependent mechanism. (Am J Pathol 2009, 174:2357-4306; DOI: 10.2353/ajpath.2009.080638)
C1 [Hansen, Laura A.] Creighton Univ, Sch Med, Dept Biomed Sci, Omaha, NE 68178 USA.
[Trempus, Carol S.; Tennant, Raymond W.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
RP Hansen, LA (reprint author), Creighton Univ, Sch Med, Dept Biomed Sci, 2500 Calif Plaza, Omaha, NE 68178 USA.
EM lhanqen@creighton.edu
RI putta, sumanth/E-3933-2010
FU National Institutes of Health (NIH) [P20 RR018759, 1RO1ES015585];
National Institute for Environmental, Health Sciences, NIH; State of
Nebraska [LB595]; National Center for Research Resources, NIH [1 CO6
RR17417-01]
FX Supported in part by the Intramural Research Program of the National
Institutes of Health (NIH). National Institute for Environmental and
Health Sciences, NIH (grants P20 RR018759 and 1RO1ES015585) and by the
State of Nebraska LB595 This investigation was conducted in a facility
constructed with support from Research Facilities Improvement Program
Grant Number 1 CO6 RR17417-01 from the National Center for Research
Resources, NIH.
NR 40
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U1 1
U2 2
PU AMER SOC INVESTIGATIVE PATHOLOGY, INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA
SN 0002-9440
J9 AM J PATHOL
JI Am. J. Pathol.
PD JUN
PY 2009
VL 174
IS 6
BP 2357
EP 2366
DI 10.2353/ajpath.2009.080638
PG 10
WC Pathology
SC Pathology
GA 449ZT
UT WOS:000266370600038
PM 19406993
ER
PT J
AU Esther, CR
Boysen, G
Olsen, BM
Collins, LB
Ghio, AJ
Swenberg, JW
Boucher, RC
AF Esther, Charles R., Jr.
Boysen, Gunnar
Olsen, Bonnie M.
Collins, Leonard B.
Ghio, Andrew J.
Swenberg, James W.
Boucher, Richard C.
TI Mass spectrometric analysis of biomarkers and dilution markers in
exhaled breath condensate reveals elevated purines in asthma and cystic
fibrosis
SO AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
LA English
DT Article
DE adenosine; adenosine monophosphate; urea
ID AIRWAY SURFACE LIQUID; ADENOSINE RECEPTORS; INFLAMMATION; DISEASE;
MONOPHOSPHATE; INFECTIONS; CHILDREN; CELLS; FLUID
AB Esther CR Jr, Boysen G, Olsen BM, Collins LB, Ghio AJ, Swenberg JW, Boucher RC. Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 296: L987-L993, 2009. First published March 20, 2009; doi: 10.1152/ajplung.90512.2008.-Exhaled breath condensate (EBC) analyses promise simple and noninvasive methods to measure airway biomarkers but pose considerable methodological challenges. We utilized mass spectrometry to measure EBC purine biomarkers adenosine and AMP plus urea to control for dilutional variability in two studies: 1) a cross-sectional analysis of 28 healthy, 40 cystic fibrosis (CF), and 11 asthmatic children; and 2) a longitudinal analysis of 26 CF children before and after treatment of a pulmonary exacerbation. EBC adenosine, AMP, and urea were readily detected and quantified by mass spectrometry, and analysis suggested significant dilutional variability. Using biomarker-to-urea ratios to control for dilution, the EBC AMP-to-urea ratio was elevated in CF [median 1.3, interquartile range (IQR) 0.7-2.3] vs. control (median 0.75, IQR 0.3-1.4; P < 0.05), and the adenosine-to-urea ratio was elevated in asthma (median 1.5, IQR 0.9-2.9) vs. control (median 0.4, IQR 0.2-1.6; P < 0.05). Changes in EBC purine-to-urea ratios correlated with changes in percent predicted forced expiratory volume in 1 s (FEV(1)) (r = -0.53 AMP/urea, r = -0.55 adenosine/ urea; P < 0.01 for both) after CF exacerbation treatment. Similar results were observed using dilution factors calculated from serum-to-EBC urea ratios or EBC electrolytes, and the comparable ratios of EBC electrolytes to urea in CF and control (median 3.2, IQR 1.6-6.0 CF; median 5.5, IQR 1.4-7.7 control) validated use of airway urea as an EBC dilution marker. These results show that mass spectrometric analyses can be applied to measurement of purines in EBC and demonstrate that EBC adenosine-to-urea and AMP-to-urea ratios are potential noninvasive biomarkers of airways disease.
C1 [Esther, Charles R., Jr.; Olsen, Bonnie M.] Univ N Carolina, Div Pediat Pulmonol, Chapel Hill, NC 27517 USA.
[Boysen, Gunnar; Collins, Leonard B.; Swenberg, James W.] Univ N Carolina, Ctr Environm Hlth & Susceptibil, Dept Environm Sci & Engn, Chapel Hill, NC 27517 USA.
[Boucher, Richard C.] Univ N Carolina, Cyst Fibrosis Res Ctr, Chapel Hill, NC 27517 USA.
[Ghio, Andrew J.] US EPA, Chapel Hill, NC USA.
RP Esther, CR (reprint author), Univ N Carolina, Div Pediat Pulmonol, 5th Floor Bioinformat,CB 7217, Chapel Hill, NC 27517 USA.
EM charles_esther@med.unc.edu
OI Boysen, Gunnar/0000-0001-8364-9881
FU UNC; Cystic Fibrosis Foundation (CFF) [ESTHER07A, ESTHER07G]; National
Institute of Environmental Health Sciences [P30 ES-10126]; National
Heart, Lung, and Blood Institute [HL-34322, HL-084934, P50 HL-084934]
FX C. R. Esther, Jr., was supported by the UNC Program for Translational
Science and the Cystic Fibrosis Foundation (CFF Grants ESTHER07A and
ESTHER07G). C. R. Esther, Jr., G. Boysen, and J. W. Swenberg were
supported by National Institute of Environmental Health Sciences Grant
P30 ES-10126. R. C. Boucher was supported by National Heart, Lung, and
Blood Institute Grants HL-34322, HL-084934, and P50 HL-084934
[Specialized Centers of Clinically Oriented Research (SCCOR)].
NR 28
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U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1040-0605
J9 AM J PHYSIOL-LUNG C
JI Am. J. Physiol.-Lung Cell. Mol. Physiol.
PD JUN
PY 2009
VL 296
IS 6
BP L987
EP L993
DI 10.1152/ajplung.90512.2008
PG 7
WC Physiology; Respiratory System
SC Physiology; Respiratory System
GA 450YQ
UT WOS:000266438300015
PM 19304910
ER
PT J
AU Samet, JM
Rappold, A
Graff, D
Cascio, WE
Berntsen, JH
Huang, YCT
Herbst, M
Bassett, M
Montilla, T
Hazucha, MJ
Bromberg, PA
Devlin, RB
AF Samet, James M.
Rappold, Ana
Graff, Donald
Cascio, Wayne E.
Berntsen, Jon H.
Huang, Yuh-Chin T.
Herbst, Margaret
Bassett, Maryann
Montilla, Tracey
Hazucha, Milan J.
Bromberg, Philip A.
Devlin, Robert B.
TI Concentrated Ambient Ultrafine Particle Exposure Induces Cardiac Changes
in Young Healthy Volunteers
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article
DE particulate matter; human; clinical study; heart rate variability;
bronchoalveolar lavage
ID HEART-RATE-VARIABILITY; PARTICULATE MATTER EXPOSURE;
CORONARY-ARTERY-DISEASE; AIR-POLLUTION; FINE PARTICULATE; DAILY
MORTALITY; ALVEOLAR MACROPHAGES; COARSE PARTICLES; HOSPITAL ADMISSIONS;
INHALED PARTICLES
AB Rationale: Exposure to ambient ultrafine particles has been associated with cardiopulmonary toxicity and mortality. Adverse effects specifically linked to ultrafine particles include loss of sympathovagal balance and altered hemostasis.
Objectives: To characterize the effects of acute exposure to ambient ultrafine particles in young healthy humans.
Methods: Nineteen healthy nonsmoking male and female subjects between the ages of 18 and 35 were exposed to filtered air or to an atmosphere in which captured ultrafine (<0.16 mu m) particles were concentrated by a factor of up to 20-fold over ambient levels with the use of particle concentrators fitted with size-selective outlets (ultrafine concentrated ambient particles [UFCAPs]). Subjects underwent bronchoalveolar lavage 18 hours after each exposure. Cardiovascular endpoints measured included pulmonary function, clinical chemistry, and hematological parameters, as well as heart rate variability and repolarization indices.
Measurements and Main Results: Exposure to UFCAPs was statistically associated with an increase in frequency domain markers of heart rate variability, specifically indicative of elevated vagal input to the heart. Consistent with this finding were increases in the variance associated with the duration of the QT interval. In addition, UFCAP exposure resulted in a significant increase in blood levels of the fibrin degradation product D-dimer as well as a modest elevation in the inflammatory chemokine IL-8 recovered in the lavage fluid.
Conclusions: These findings show mild inflammatory and prothrombic responses and are suggestive of alterations in cardiac repolarization induced by UFCAP inhalation.
C1 [Samet, James M.; Rappold, Ana; Graff, Donald; Huang, Yuh-Chin T.; Bassett, Maryann; Montilla, Tracey; Devlin, Robert B.] Natl Hlth & Environm Effects Res Lab, Human Studies Div, Res Triangle Pk, NC USA.
[Cascio, Wayne E.] E Carolina Univ, Brody Sch Med, Greenville, NC USA.
[Berntsen, Jon H.] TRC Corp, Chapel Hill, NC USA.
[Herbst, Margaret; Hazucha, Milan J.; Bromberg, Philip A.] Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA.
RP Samet, JM (reprint author), US EPA, Human Studies Div, 104 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM samet.james@epa.gov
NR 71
TC 81
Z9 85
U1 0
U2 12
PU AMER THORACIC SOC
PI NEW YORK
PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD JUN 1
PY 2009
VL 179
IS 11
BP 1034
EP 1042
DI 10.1164/rccm.200807-1043OC
PG 9
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA 451ZK
UT WOS:000266509200012
PM 19234105
ER
PT J
AU Wyrzykowska, B
Tabor, D
Gullett, BK
AF Wyrzykowska, Barbara
Tabor, Dennis
Gullett, Brian K.
TI Same-Sample Determination of Ultratrace Levels of
Polybromodiphenylethers, Polybromodibenzo-p-dioxins/Furans, and
Polychlorodibenzo-p-dioxins/Furans from Combustion Flue Gas
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID BROMINATED FLAME RETARDANTS; POLYBROMINATED DIPHENYL ETHERS;
MASS-SPECTROMETRY; PBDE LEVELS; DIBENZOFURANS; CONGENERS; DECOMPOSITION;
BIPHENYLS; MIXTURES; BEHAVIOR
AB The analytical method used for determination of polychlorinated dibenzo-p-dioxins and -furans (PCDDs/Fs) emissions from municipal waste combustors (MWCs) and other stationary sources was modified and validated to additionally allow for analysis of ultratrace levels of polybrominated diphenyl ethers (PBDEs) and polybrominated dibenzo-p-dioxins and -furans (PBDDs/Fs) from a common flue gas sample. Potential methodological problems related to physicochemical properties of brominated compounds, including UV- and temperature-induced debromination and degradation, were addressed. The selection of solvents, optimization of extraction time, and adaptation of the cleanup and fractionation steps increased mean recoveries of (13)C(12)-labeled PBDE and PBDD/F isotope dilution surrogates about 18% and 25%, respectively. The customary liquid chromatography isolation of PBDEs and PBDDs/Fs was replaced by optimization of high-resolution gas chromatography to separate target PBDFs (2,3,7,8-Br-substituted) from potentially interfering PBDEs before mass spectroscopic identification. The optimized method allowed quantitative determination of 56 mono- through decabromodiphenylether congeners, 15 congeners of 2,3,7-and 2,3,7,8-Br-substituted tri- to octabromodibenzo-p-dioxins and -furans, and all 210 polychlorinated dibenzo-p-dioxins and -furans present in the flue gas at levels of picogram, to microgram per normalized cubic meter.
C1 [Wyrzykowska, Barbara; Tabor, Dennis; Gullett, Brian K.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Wyrzykowska, Barbara] Oak Ridge Inst Sci & Educ Res Postdoctoral Progra, Oak Ridge, TN 37831 USA.
RP Gullett, BK (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, E305-01, Res Triangle Pk, NC 27711 USA.
FU U.S. Department of Energy; U.S. Environmental Protection Agency
FX This research was supported in part by the appointment of the
Postdoctoral Research Program at the National Risk Management Research
Laboratory, administered by the Oak Ridge Institute for Science and
Education through an Interagency Agreement between the U.S. Department
of Energy and the U.S. Environmental Protection Agency. The authors
thank Dr. Abderrahmane Touati (ARCADIS Inc., U.SA) for his technical
help and Dr. Heather Stapleton (Duke University) for providing standards
of selected hepta- and octa-BDEs. We want to express special
acknowledgments to all the staff at the MWC sampling site.
NR 46
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U1 4
U2 21
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
J9 ANAL CHEM
JI Anal. Chem.
PD JUN 1
PY 2009
VL 81
IS 11
BP 4334
EP 4342
DI 10.1021/ac900105a
PG 9
WC Chemistry, Analytical
SC Chemistry
GA 453HP
UT WOS:000266601800026
PM 19422255
ER
PT J
AU Bailey, CM
Kasiviswanathan, R
Copeland, WC
Anderson, KS
AF Bailey, Christopher M.
Kasiviswanathan, Rajesh
Copeland, William C.
Anderson, Karen S.
TI R964C Mutation of DNA Polymerase gamma Imparts Increased Stavudine
Toxicity by Decreasing Nucleoside Analog Discrimination and Impairing
Polymerase Activity
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID MITOCHONDRIAL TOXICITY; ANTIRETROVIRAL THERAPY; REVERSE-TRANSCRIPTASE;
SUBUNIT; INHIBITORS; DRUGS
AB The R964C mutation of human DNA polymerase gamma was recently linked to stavudine (d4T)-mediated mitochondrial toxicity. We utilized pre-steady-state kinetics to determine the effect of this mutation on incorporation of natural substrate dTTP and the active metabolite of d4T (d4TTP). The R964C polymerase gamma holoenzyme demonstrated a 33% decrease in dTTP incorporation efficiency and a threefold-lower d4TTP discrimination relative to that of the wild-type polymerase gamma, providing a mechanistic basis for genetic predisposition to nucleoside reverse transcriptase inhibitor toxicity.
C1 [Bailey, Christopher M.; Anderson, Karen S.] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA.
[Kasiviswanathan, Rajesh; Copeland, William C.] Natl Inst Environm Hlth Sci, Mol Genet Lab, Res Triangle Pk, NC 27709 USA.
RP Anderson, KS (reprint author), Yale Univ, Sch Med, Dept Pharmacol, 333 Cedar St, New Haven, CT 06520 USA.
EM karen.anderson@yale.edu
RI Kasiviswanathan, Rajesh/D-2744-2012;
OI Bailey, Chris/0000-0002-5962-9511
FU NIH [GM49551, ES065080]
FX This work was supported by NIH GM49551 to K. S. A. and NIH intramural
research funds (ES065080) to W. C. C.
NR 22
TC 26
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U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD JUN
PY 2009
VL 53
IS 6
BP 2610
EP 2612
DI 10.1128/AAC.01659-08
PG 3
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 448DY
UT WOS:000266244500052
PM 19364868
ER
PT J
AU Yang, WL
Lindquist, HDA
Cama, V
Schaefer, FW
Villegas, E
Fayer, R
Lewis, EJ
Feng, YY
Xiao, LH
AF Yang, Wenli
Lindquist, H. D. Alan
Cama, Vitaliano
Schaefer, Frank W., III
Villegas, Eric
Fayer, Ronald
Lewis, Earl J.
Feng, Yaoyu
Xiao, Lihua
TI Detection of Toxoplasma gondii Oocysts in Water Sample Concentrates by
Real-Time PCR
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID POLYMERASE-CHAIN-REACTION; TRANSFER HYBRIDIZATION PROBES; IMMUNOMAGNETIC
SEPARATION; CONGENITAL TOXOPLASMOSIS; OCULAR TOXOPLASMOSIS; QUANTITATIVE
PCR; INTERNAL CONTROL; DRINKING-WATER; DIAGNOSIS; ASSAY
AB PCR techniques in combination with conventional parasite concentration procedures have potential for the sensitive and specific detection of Toxoplasma gondii oocysts in water. Three real-time PCR assays based on the B1 gene and a 529-bp repetitive element were analyzed for the detection of T. gondii tachyzoites and oocysts. Lower sensitivity and specificity were obtained with the B1 gene-based PCR than with the 529-bp repeat-based PCR. New procedures for the real-time PCR detection of T. gondii oocysts in concentrates of surface water were developed and tested in conjunction with a method for the direct extraction of inhibitor-free DNA from water. This technique detected as few as one oocyst seeded to 0.5 ml of packed pellets from water samples concentrated by Envirocheck filters. Thus, this real-time PCR may provide a detection method alternative to the traditional mouse assay and microscopy.
C1 [Xiao, Lihua] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30341 USA.
[Yang, Wenli] Atlanta Res & Educ Fdn, Decatur, GA 30033 USA.
[Lindquist, H. D. Alan; Schaefer, Frank W., III] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
[Villegas, Eric] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
[Fayer, Ronald] USDA ARS, Beltsville, MD 20705 USA.
[Lewis, Earl J.] Natl Ocean & Atmospher Adm, Ctr Coastal Environm Hlth & Biomol Res, Oxford, MD 21654 USA.
[Feng, Yaoyu] E China Univ Sci & Technol, Sch Resource & Environm Engn, Shanghai 200237, Peoples R China.
RP Xiao, LH (reprint author), Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Bldg 22,Mail Stop F-12,4770 Buford Highway, Atlanta, GA 30341 USA.
EM lxiao@cdc.gov
RI Xiao, Lihua/B-1704-2013; Feng, Yaoyu/B-3076-2014; Villegas,
Eric/A-7373-2015
OI Xiao, Lihua/0000-0001-8532-2727; Villegas, Eric/0000-0002-8059-8588
FU EPA; National Oceanic and Atmospheric Administration Oceans and Human
Health Initiative
FX This study was supported in part by funds from the EPA and the National
Oceanic and Atmospheric Administration Oceans and Human Health
Initiative.
NR 58
TC 15
Z9 17
U1 0
U2 11
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD JUN 1
PY 2009
VL 75
IS 11
BP 3477
EP 3483
DI 10.1128/AEM.00285-09
PG 7
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 449QT
UT WOS:000266345800012
PM 19363083
ER
PT J
AU Rastogi, VK
Wallace, L
Smith, LS
Ryan, SP
Martin, B
AF Rastogi, Vipin K.
Wallace, Lalena
Smith, Lisa S.
Ryan, Shawn P.
Martin, Blair
TI Quantitative Method To Determine Sporicidal Decontamination of Building
Surfaces by Gaseous Fumigants, and Issues Related to Laboratory-Scale
Studies
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID BACILLUS-ANTHRACIS; SPORES; DISINFECTANTS
AB Chlorine dioxide gas and vaporous hydrogen peroxide sterilant have been used in the cleanup of building interiors contaminated with spores of Bacillus anthracis. A systematic study, in collaboration with the U. S. Environmental Protection Agency, was jointly undertaken by the U. S. Army-Edgewood Chemical Biological Center to determine the sporicidal efficacies of these two fumigants on six building structural materials: carpet, ceiling tile, unpainted cinder block, painted I-beam steel, painted wallboard, and unpainted pinewood. Critical issues related to high-throughput sample processing and spore recovery from porous and nonporous surfaces included (i) the extraction of spores from complex building materials, (ii) the effects of titer challenge levels on fumigant efficacy, and (iii) the impact of bioburden inclusion on spore recovery from surfaces and spore inactivation. Small pieces (1.3 by 1.3 cm of carpet, ceiling tile, wallboard, I-beam steel, and pinewood and 2.5 by 1.3 cm for cinder block) of the materials were inoculated with an aliquot of 50 mu l containing the target number (1 x 10(6), 1 x 10(7), or 1 x 10(8)) of avirulent spores of B. anthracis NNR1 Delta 1. The aliquot was dried overnight in a biosafety cabinet, and the spores were extracted by a combination of a 10-min sonication and a 2-min vortexing using 0.5% buffered peptone water as the recovery medium. No statistically significant drop in the kill efficacies of the fumigants was observed when the spore challenge level was increased from 6 log units to 8 log units, even though a general trend toward inhibition of fumigant efficacy was evident. The organic burden (0 to 5%) in the spore inoculum resulted in a statistically significant drop in spore recovery (at the 2 or 5% level). The effect on spore killing was a function of the organic bioburden amount and the material type. In summary, a high-throughput quantitative method was developed for determining the efficacies of fumigants, and the spore recoveries from five porous materials and one nonporous material ranged between 20 and 80%.
C1 [Rastogi, Vipin K.; Wallace, Lalena; Smith, Lisa S.] USA, Edgewood Chem Biol Ctr, R&T Directorate, BioDef Team, Aberdeen Proving Ground, MD 21010 USA.
[Ryan, Shawn P.] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA.
[Martin, Blair] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
RP Rastogi, VK (reprint author), E-3150 Kingscreek St N, Aberdeen Proving Ground, MD 21010 USA.
EM vipin.rastogi@us.army.mil
RI Wallace, Lance/K-7264-2013
FU U. S. EPA through its Office of Research and Development; Department of
the Army, ECBC [DW-2193991701]
FX This study has been subjected to an administrative review but does not
necessarily reflect the views of the U. S. EPA. No official endorsement
should be inferred. The U. S. EPA does not endorse the purchase or sale
of any commercial products or services.
NR 18
TC 29
Z9 30
U1 1
U2 10
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD JUN 1
PY 2009
VL 75
IS 11
BP 3688
EP 3694
DI 10.1128/AEM.02592-08
PG 7
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 449QT
UT WOS:000266345800039
PM 19346341
ER
PT J
AU Sickles, JE
Shadwick, DS
Kilaru, JV
Grimm, JW
AF Sickles, Joseph E.
Shadwick, Douglas S.
Kilaru, J. Vasu
Grimm, Jeffrey W.
TI Errors in representing regional acid deposition with spatially sparse
monitoring: Case studies of the eastern US using model predictions
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Spatial representation; Deposition; Sulfate; Nitrate; Ammonium; Hydrogen
ion; Precipitation
ID ATMOSPHERIC SULFUR; UNITED-STATES; TRENDS
AB The current study uses case studies of model-predicted regional precipitation and wet ion deposition over 5-year periods to estimate errors in corresponding regional values derived from the means of site-specific values within regions of interest located in the eastern US. The mean of model-predicted site-specific values for sites within each region was found generally to overestimate the corresponding model-predicted regional wet ion deposition. On an annual basis across four regions in the eastern US, these overestimates of regional wet ion deposition were typically between 5 and 25% and may be more exaggerated for individual seasons. Corresponding overestimates of regional precipitation were typically <5%, but may be more exaggerated for individual seasons. Period-to-period relative changes determined from the mean of site-based model-predicted wet deposition for the current regional ensembles of sites generally estimated larger beneficial effects of pollutant emissions reductions in comparison to changes based on model-predicted regional wet deposition. On an annual basis site-based relative changes were generally biased low compared to regional relative changes: differences were typically <7%, but they may also be more exaggerated for individual seasons. Spatial heterogeneities of the wet ion deposition fields with respect to the sparse monitoring site locations prevented the monitoring sites considered in the current study from providing regionally representative results. Monitoring site locations considered in the current study over-represent the geographical areas subject to both high emissions and high wet ion deposition and under-represent the geographical areas subject to low emissions and low wet deposition. Since the current case studies consider only those eastern US site locations that have supported concurrent wet and dry deposition monitoring, similar errors may be expected for dry and total deposition using results from the same monitoring site locations. Current case study results illustrate the approximate range of potential errors and suggest caution when inferring regional acid deposition from a network of sparse monitoring sites. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Sickles, Joseph E.; Kilaru, J. Vasu] US EPA, ORD, NERL, Res Triangle Pk, NC 27711 USA.
[Shadwick, Douglas S.] Comp Sci Corp, Durham, NC 27713 USA.
[Grimm, Jeffrey W.] Penn State Univ, Environm Resources Inst, University Pk, PA 16802 USA.
RP Sickles, JE (reprint author), US EPA, ORD, NERL, Res Triangle Pk, NC 27711 USA.
EM sickles.joseph@epa.gov
FU US EPA [68-W01032]
FX The US EPA, through its Office of Research and Development, funded and
partially performed the research described here under contract
68-W01032, to CSC Corporation. This manuscript has been subjected to
Agency review and approved for publication.
NR 16
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U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD JUN
PY 2009
VL 43
IS 18
BP 2855
EP 2861
DI 10.1016/j.atmosenv.2009.03.018
PG 7
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 452BZ
UT WOS:000266515900002
ER
PT J
AU Olson, DA
Mcdow, SR
AF Olson, David A.
McDow, Stephen R.
TI Near roadway concentrations of organic source markers
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Organic source markers; Source apportionment; Hopanes; Polycyclic
aromatic hydrocarbons (PAHs); Traffic
ID POLYCYCLIC AROMATIC-HYDROCARBONS; AIR-POLLUTION SOURCES; PARTICULATE
MATTER; ELEMENTAL CARBON; DIESEL EXHAUST; SOURCE APPORTIONMENT;
ULTRAFINE PARTICLES; RESPIRATORY HEALTH; CHILDHOOD ASTHMA; MAJOR HIGHWAY
AB Concentrations of elemental carbon (EC), organic carbon (OC), and 33 organic source markers (12 alkanes, 18 polycyclic aromatic hydrocarbons and ketones, and 3 hopanes) are reported near a highway in Raleigh, NC with an annual average daily traffic count of approximately 125,000 vehicles. Daily samples (24-h) were collected at two locations, one approximately 10 m and the other 275 m perpendicular from the road. Concentrations of OC were similar between near (mean = 7.6 mu g m(-3)) and far (8.0 mu g m(-3)) locations, but concentrations of most organic species at the near site were between 1.5 and 2 times higher than those at the far site. Published by Elsevier Ltd.
C1 [Olson, David A.; McDow, Stephen R.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Olson, DA (reprint author), US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM olson.david@epa.gov
NR 29
TC 11
Z9 11
U1 1
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD JUN
PY 2009
VL 43
IS 18
BP 2862
EP 2867
DI 10.1016/j.atmosenv.2009.03.016
PG 6
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 452BZ
UT WOS:000266515900003
ER
PT J
AU Johnson, KC
Durbin, TD
Cocker, DR
Miller, WJ
Bishnu, DK
Maldonado, H
Moynahan, N
Ensfield, C
Laroo, CA
AF Johnson, K. C.
Durbin, T. D.
Cocker, D. R., III
Miller, W. J.
Bishnu, D. K.
Maldonado, H.
Moynahan, N.
Ensfield, C.
Laroo, C. A.
TI On-road comparison of a portable emission measurement system with a
mobile reference laboratory for a heavy-duty diesel vehicle
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE PEMS; On-road; In-use; Heavy-duty diesel; Semtech DS; Not-to-exceed
(NTE)
ID ENGINES
AB On-road comparisons were made between a mobile emissions laboratory (MEL) meeting federal standards and a portable emissions measurement system (PEMS). These comparisons were made over different conditions; including road grade, vibration, altitude, electric fields, and humidity with the PEMS mounted inside and outside of the tractor's cab. Brake-specific emissions were calculated to explore error differences between the MEL and PEMS during the Not-To-Exceed (NTE) engine operating zone. The PEMS brake-specific NOx (bsNOx) NTE emissions were biased high relative to the MEL and, in general, were about 8% of the 2007 in-use NTE NO(x) standard of 2.68 g kW(-1) h(-1) (2.0 g hp(-1) h(-1)). The bSCO(2) emissions for the PEMS were also consistently biased high relative to the MEL with an average deviation of +4% +/- 2%. NMHC and CO emissions were very low and typically less than 1% of the NTE threshold. This research was part of a comprehensive program to determine the "allowance" when PEMS are used for in use compliance testing of heavy-duty diesel vehicles (HDDVs). (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Johnson, K. C.; Durbin, T. D.; Cocker, D. R., III; Miller, W. J.] Univ Calif Riverside, Dept Chem & Environm Engn, Bourns Coll Engn, CE CERT, Riverside, CA 92521 USA.
[Bishnu, D. K.; Maldonado, H.] Calif Air Resources Board, Sacramento, CA 95815 USA.
[Moynahan, N.] Caterpillar Inc, Peoria, IL 61656 USA.
[Ensfield, C.] Sensors Inc, Saline, MI 48176 USA.
[Laroo, C. A.] US EPA, Ann Arbor, MI 48105 USA.
RP Johnson, KC (reprint author), Univ Calif Riverside, Dept Chem & Environm Engn, Bourns Coll Engn, CE CERT, 1084 Columbia Ave, Riverside, CA 92521 USA.
EM kjohnson@cert.ucr.edu
RI Cocker, David/F-4442-2010
OI Cocker, David/0000-0002-0586-0769
NR 23
TC 21
Z9 24
U1 5
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD JUN
PY 2009
VL 43
IS 18
BP 2877
EP 2883
DI 10.1016/j.atmosenv.2009.03.019
PG 7
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 452BZ
UT WOS:000266515900005
ER
PT J
AU Venkatram, A
Isakov, V
Seila, R
Baldauf, R
AF Venkatram, Akula
Isakov, Vlad
Seila, Robert
Baldauf, Richard
TI Modeling the impacts of traffic emissions on air toxics concentrations
near roadways
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Air quality; Roadways; Air toxics; Dispersion modeling; Mobile sources;
Benzene; Toluene; 1,3-Butadiene
ID BOUNDARY-LAYER; NEAR-ROAD; DISPERSION; QUALITY
AB The dispersion formulation incorporated in the U.S. Environmental Protection Agency's AERMOD regulatory dispersion model is used to estimate the contribution of traffic-generated emissions of select VOCs - benzene, 1,3-butadiene, toluene - to ambient air concentrations at downwind receptors ranging from 10-m to 100-m from the edge of a major highway in Raleigh. North Carolina. The contributions are computed using the following steps: 1) Evaluate dispersion model estimates with 10-min averaged NO data measured at 7 m and 17 m from the edge of the road during a field study conducted in August, 2006; this step determines the uncertainty in model estimates. 2) Use dispersion model estimates and their uncertainties, determined in step 1, to construct pseudo-observations. 3) Fit pseudo-observations to actual observations of VOC concentrations measured during five periods of the field study. This provides estimates of the contributions of traffic emissions to the VOC concentrations at the receptors located from 10 m to 100 m from the road. In addition, it provides estimates of emission factors and background concentrations of the VOCs, which are supported by independent estimates from motor vehicle emissions models and regional air quality measurements. The results presented in the paper demonstrate the suitability of the formulation in AERMOD for estimating concentrations associated with mobile source emissions near roadways. This paper also presents an evaluation of the key emissions and dispersion modeling inputs necessary for conducting assessments of local-scale impacts from traffic emissions. Published by Elsevier Ltd.
C1 [Isakov, Vlad; Seila, Robert] US EPA, Atmospher Modeling Div, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Baldauf, Richard] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Venkatram, Akula] Univ Calif Riverside, Riverside, CA 92521 USA.
RP Isakov, V (reprint author), US EPA, Atmospher Modeling Div, Off Res & Dev, Natl Exposure Res Lab, MD E243-04,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM isakov.vlad@epa.gov
NR 16
TC 20
Z9 20
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD JUN
PY 2009
VL 43
IS 20
BP 3191
EP 3199
DI 10.1016/j.atmosenv.2009.03.046
PG 9
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 459PY
UT WOS:000267117100005
ER
PT J
AU Fairlie, TD
Szykman, J
Gilliland, A
Pierce, RB
Kittaka, C
Weber, S
Engel-Cox, J
Rogers, RR
Tikvart, J
Scheffe, R
Dimmick, F
AF Fairlie, T. Duncan
Szykman, James
Gilliland, Alice
Pierce, R. Bradley
Kittaka, Chieko
Weber, Stephanie
Engel-Cox, Jill
Rogers, Raymond R.
Tikvart, Joe
Scheffe, Rich
Dimmick, Fred
TI Lagrangian sampling of 3-D air quality model results for regional
transport contributions to sulfate aerosol concentrations at Baltimore,
MD, in summer 2004
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Air quality; Source apportionment modeling; CAIR; CMAQ; Satellite;
MODIS; Sulfate; Particulate matter
ID FINE PARTICULATE MATTER; UNITED-STATES; OPTICAL DEPTH; TRENDS;
VALIDATION; OZONE
AB We use ensemble-mean Lagrangian sampling of a 3-D Eulerian air quality model, CMAQ together with ground-based ambient monitors data from several air monitoring networks and satellite (MODIS) observations to provide source apportionment and regional transport vs. local contributions to sulfate aerosol and PM2.5 concentrations at Baltimore, MD, for summer 2004. The Lagrangian method provides estimates of the chemical and physical evolution of air arriving in the daytime boundary layer at Baltimore. Study results indicate a dominant role for regional transport contributions on those days when sulfate air pollution is highest in Baltimore, with a principal transport pathway from the Ohio River Valley (ORV) through southern Pennsylvania and Maryland, consistent with earlier studies. Thus, reductions in sulfur emissions from the ORV under the EPA's Clean Air Interstate Rule may be expected to improve particulate air quality in Baltimore during summer. The Lagrangian sampling of CMAQ offers an inexpensive and complimentary approach to traditional methods of source apportionment based on multivariate observational data analysis, and air quality model emissions separation. This study serves as a prototype for the method applied to Baltimore. EPA is establishing a system to allow air quality planners to readily produce and access equivalent results for locations of their choice. Published by Elsevier Ltd.
C1 [Fairlie, T. Duncan] US Natl Aeronaut & Space Adm, Langley Res Ctr, Sci Directorate, Hampton, VA 23681 USA.
[Szykman, James; Gilliland, Alice; Dimmick, Fred] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Pierce, R. Bradley] Natl Environm Satellite Data & Informat Serv, Natl Ocean & Atmospher Adm, Madison, WI 53706 USA.
[Kittaka, Chieko; Rogers, Raymond R.] Sci Applicat Int Corp SSAI, Hampton, VA 23666 USA.
[Weber, Stephanie] Battelle Mem Inst, Columbus, OH 43201 USA.
[Engel-Cox, Jill] Battelle Mem Inst, Arlington, VA 22201 USA.
[Tikvart, Joe; Scheffe, Rich] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Fairlie, TD (reprint author), US Natl Aeronaut & Space Adm, Langley Res Ctr, Sci Directorate, Hampton, VA 23681 USA.
EM t.d.fairlie@larc.nasa.gov
RI Pierce, Robert Bradley/F-5609-2010; Wang, Linden/M-6617-2014
OI Pierce, Robert Bradley/0000-0002-2767-1643;
FU NASA Applied Sciences Program; EPA
FX We wish to thank Tanya Otte, Alfreida Torian, and colleagues at Research
Triangle Park for providing the CMAQ model and MCIP meteorological
fields used in this study. We thank CIMSS, University of Wisconsin, for
use of the MODIS data. We thank the AERONET and IMPROVE science teams
for use of their data. We thank Ray Hoff (UMBQ for use of the ELF data.
Thanks to Matt Seybold (NOAA NESDIS), Mike Woodman (Maryland Department
of Environment), and to Susan Wierman (Mid-Atlantic Regional Management
Association - MARAMA) for reviews on this work. Thanks to Jeff Stehr
(University of Maryland), and Dev Roy (US EPA) for their technical input
and discussions, and to the anonymous reviewers of this manuscript for
their comments and suggestions. We thank Lawrence Friedl and Doreen Neil
for supporting this work through the NASA Applied Sciences Program.
Additional support was provided by EPA through the EPA Global Earth
Observation (GEO) Advance Monitoring Initiative (AMI). The views
expressed and findings contained in this paper are those of the authors
and should not be construed as official NASA, EPA, NOAA, or U.S.
Government position, policy, or decision.
NR 39
TC 12
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U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD JUN
PY 2009
VL 43
IS 20
BP 3275
EP 3288
DI 10.1016/j.atmosenv.2009.02.026
PG 14
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 459PY
UT WOS:000267117100015
ER
PT J
AU Vu, KD
Tyagi, RD
Valero, JR
Surampalli, RY
AF Vu, Khanh Dang
Tyagi, R. D.
Valero, J. R.
Surampalli, R. Y.
TI Impact of different pH control agents on biopesticidal activity of
Bacillus thuringiensis during the fermentation of starch industry
wastewater
SO BIOPROCESS AND BIOSYSTEMS ENGINEERING
LA English
DT Article
DE Starch industry wastewater; Bacillus thuringiensis var. kurstaki;
Entomotoxicity; Biopesticides; Bioconversion
ID DELTA-ENDOTOXIN PRODUCTION; RHIZOPUS-ARRHIZUS; SUBSP ISRAELENSIS;
NITROGEN; CRYSTAL; STRAINS; PROTEIN; CEREUS; GROWTH; MEDIA
AB Different pH control agents (NaOH/H2SO4-SodSulp, NaOH/CH3COOH-SodAcet, NH4OH/CH3COOH-AmmoAcet and NH4OH/H2SO4-AmmoSulp) were used to investigate their effects on growth, enzyme production (alkaline protease and amylase), and entomotoxicity of Bacillus thuringiensis var. kurstaki HD-1 (Btk) against eastern spruce budworm larvae (Choristoneura fumiferana) using starch industry wastewater (SIW) as a raw material in a 15-l fermentor. AmmoSulp and SodSulp were found to be the best pH control agents for alkaline protease and amylase production, respectively; whereas, the fermented broth obtained by using SodAcet as pH control agents recorded the highest delta-endotoxin production of 1043.0 mg/l and entomotoxicity value 18.4 x 10(9) SBU/l. Entomotoxicity of re-suspended centrifuged pellet in one-tenth of original volume in case of SodAcet as pH control agents was 26.7 x 10(9) SBU/l and was the highest value compared to three other pH control agents.
C1 [Vu, Khanh Dang; Tyagi, R. D.; Valero, J. R.] Univ Quebec, INRS ETE, Quebec City, PQ G1K 9A9, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP Tyagi, RD (reprint author), Univ Quebec, INRS ETE, 490 Rue Couronne, Quebec City, PQ G1K 9A9, Canada.
EM tyagi@ete.inrs.ca
FU Natural Sciences and Engineering Research Council of Canada [A4984]
FX The authors are sincerely thankful to the Natural Sciences and
Engineering Research Council of Canada (Grant A4984, Canada Research
Chair) for financial support. The views and opinions expressed in this
article are strictly those of authors. Sincere thanks to Dr. Satinder K.
Brar and Dr. Simon Barnabe for reading and providing suggestions to
prepare the manuscripts.
NR 36
TC 8
Z9 9
U1 2
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1615-7591
EI 1615-7605
J9 BIOPROC BIOSYST ENG
JI Bioprocess. Biosyst. Eng.
PD JUN
PY 2009
VL 32
IS 4
BP 511
EP 519
DI 10.1007/s00449-008-0271-z
PG 9
WC Biotechnology & Applied Microbiology; Engineering, Chemical
SC Biotechnology & Applied Microbiology; Engineering
GA 448CE
UT WOS:000266238900010
PM 18979122
ER
PT J
AU Hosako, H
Martin, GS
Barrier, M
Chen, YA
Ivanov, IV
Mirkes, PE
AF Hosako, Hiromi
Martin, Gail S.
Barrier, Marianne
Chen, Yian A.
Ivanov, Ivan V.
Mirkes, Philip E.
TI Gene and MicroRNA Expression in p53-Deficient Day 8.5 Mouse Embryos
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Article; Proceedings Paper
CT 48th Annual Meeting of the Teratology-Society
CY JUN 28-JUL 02, 2008
CL Monterey, CA
SP Teratol Soc
DE microarray; miRNA; neural tube defects; p53
ID NEURAL-TUBE DEFECTS; RETINOIC ACID RECEPTORS; TUMOR-SUPPRESSOR GENES;
DNA-DAMAGE; HISTONE H2AX; TRANSCRIPTIONAL ACTIVATION; GROWTH-CONTROL;
MESSENGER-RNA; P53 PATHWAY; VITAMIN USE
AB BACKGROUND: Neural tube defects (NTDs) are one of the most common human birth defects, with a prevalence of approximately I in 1000 live births in the United States. In animal studies, deletion of p53 leads to a significant increase in embryos that exhibit exencephaly. Whereas several studies have closely investigated the morphologic changes of p53-deficient embryos, no study has reported the molecular-level alteration in p53-deficient embryos. Here we attempt to identify genes and microRNAs (miRNAs) modified by deletion of p53 in day 8.5 mouse embryos. METHODS: Mouse embryos from p53 heterozygous crosses were collected, genotyped, and embryos of similar genotype (+/+; +/-; -/-) were pooled. RNA from the pooled samples was isolated to determine mRNA and miRNA expression levels using Whole Genome Bioarrays and Low Density Arrays, respectively. RESULTS: In p53 -/- embryos, 388 genes showed statistically significant alteration in gene expression of more than twofold compared to p53 +/+ embryos. Expression of p53 and well known p53 target genes, such as p21 and cyclin G1, were significantly down-regulated in p53 -/- embryos. In contrast, expression of other p53 target genes, such as Mdm2, Noxa, and Puma, were unchanged. We also identified six genes (Csk, Itga3, Jarid2, Prkaca, Rarg, and Sall4), known to cause NTDs when deleted, that are also down-regulated in p53 -/- embryos. Finally, five miRNAs (mir-1, mir-30e-3p, mir-142-3p, mir-301, and mir-331) also showed statistically significant alterations in expression levels in p53 -/- embryos compared to p53 +/+ embryos. Combined analysis of the experimental data using step-wise regression model and two publicly available algorithms identified putative target genes of these miRNAs. CONCLUSIONS: Our data have identified genes and miRNAs that may be involved in the mechanisms underlining NTDs and begin to define the developmental role of p53 in the etiology of NTDs. Birth Defects Research (Part A) 85:546-555, 2009. (C) 2009 Wiley-Liss, Inc.
C1 [Hosako, Hiromi; Martin, Gail S.; Ivanov, Ivan V.; Mirkes, Philip E.] Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA.
[Barrier, Marianne] US EPA, Gamete & Early Embryo Biol Branch RTD, NHEERL, ORD, Res Triangle Pk, NC 27711 USA.
[Chen, Yian A.] Texas A&M Univ, Dept Stat, College Stn, TX 77843 USA.
RP Hosako, H (reprint author), Texas A&M Univ, Dept Vet Physiol & Pharmacol, 434 VMR Bldg, College Stn, TX 77843 USA.
EM hhosako@cvm.tamu.edu
FU NIEHS NIH HHS [R01ES07026, P30ES07033, R01ES08744]; PHS HHS [P30EX09106]
NR 83
TC 15
Z9 16
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD JUN
PY 2009
VL 85
IS 6
BP 546
EP 555
DI 10.1002/bdra.20565
PG 10
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 463YY
UT WOS:000267471400005
PM 19229884
ER
PT J
AU Glaser, JA
AF Glaser, John A.
TI Biocatalyst enhancement
SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY
LA English
DT News Item
C1 US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Glaser, JA (reprint author), US EPA, Natl Risk Management Res Lab, 26 W King Dr, Cincinnati, OH 45268 USA.
EM Glaser.John@epa.go
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1618-954X
J9 CLEAN TECHNOL ENVIR
JI Clean Technol. Environ. Policy
PD JUN
PY 2009
VL 11
IS 2
BP 147
EP 151
DI 10.1007/s10098-009-0233-4
PG 5
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental;
Environmental Sciences
SC Science & Technology - Other Topics; Engineering; Environmental Sciences
& Ecology
GA 456BG
UT WOS:000266812400003
ER
PT J
AU Sikdar, SK
AF Sikdar, Subhas K.
TI On aggregating multiple indicators into a single metric for
sustainability
SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY
LA English
DT Article
AB In sustainability analysis of multidimensional states of a system, it is required to establish the relative superiority of one of the states. Particularly when a finite number of quantitative metrics is used to characterize the system, the values of the metrics among the states can exhibit increasing and decreasing trends at the same time, creating difficulty in clearly preferring one to the other. Sometimes, unequal weighting factors are ascribed to metrics to show the relative importance of the metrics, further complicating the comparison. It has been deemed desirable to consolidate all the usable metrics into one aggregate metric to make this comparison easier. Such an attempt is provided here by expressing the aggregate metric as the geometric mean of the ratios of the individual metrics for pair-wise comparisons. This computation was applied to previously reported evaluations of processes with a finite number of metrics. The method also reveals the sensitivity of the aggregate metric to the individual metrics and to the weighting factors.
C1 US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Sikdar, SK (reprint author), US EPA, Natl Risk Management Res Lab, 26 WML King Dr, Cincinnati, OH 45268 USA.
EM sikdar.subhas@epa.gov
NR 5
TC 31
Z9 32
U1 1
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1618-954X
J9 CLEAN TECHNOL ENVIR
JI Clean Technol. Environ. Policy
PD JUN
PY 2009
VL 11
IS 2
BP 157
EP 161
DI 10.1007/s10098-009-0225-4
PG 5
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental;
Environmental Sciences
SC Science & Technology - Other Topics; Engineering; Environmental Sciences
& Ecology
GA 456BG
UT WOS:000266812400004
ER
PT J
AU Snook, CP
AF Snook, C. P.
TI Decontamination in Response to Natural Anthrax Incidents
SO CLINICAL TOXICOLOGY
LA English
DT Meeting Abstract
C1 [Snook, C. P.] US EPA, Natl Decontaminat Team, Cincinnati, OH 45268 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 1556-3650
J9 CLIN TOXICOL
JI Clin. Toxicol.
PD JUN
PY 2009
VL 47
IS 5
MA 29
BP 446
EP 446
PG 1
WC Toxicology
SC Toxicology
GA 473LO
UT WOS:000268208400040
ER
PT J
AU Garmestani, AS
Allen, CR
Gunderson, L
AF Garmestani, Ahjond S.
Allen, Craig R.
Gunderson, Lance
TI Panarchy: Discontinuities Reveal Similarities in the Dynamic System
Structure of Ecological and Social Systems
SO ECOLOGY AND SOCIETY
LA English
DT Article
DE panarchy; discontinuities; complex systems; regime shifts; resilience
ID COMPLEX ADAPTIVE SYSTEMS; CITY SIZE DISTRIBUTIONS; BODY-SIZE; RATIONAL
ROUTE; REGIME SHIFTS; SCALE; RESILIENCE; ECOSYSTEMS; BIODIVERSITY;
LANDSCAPES
AB In this paper, we review the empirical evidence of discontinuous distributions in complex systems within the context of panarchy theory and discuss the significance of discontinuities for understanding emergent properties such as resilience. Over specific spatial-temporal scale ranges, complex systems can configure in a variety of regimes, each defined by a characteristic set of self-organized structures and processes. A system may remain within a regime or dramatically shift to another regime. Understanding the drivers of regime shifts has provided critical insight into system structure and resilience. Although analyses of regime shifts have tended to focus on the system level, new evidence suggests that the same system behaviors operate within scales. In essence, complex systems exhibit multiple dynamic regimes nested within the larger system, each of which operates at a particular scale. Discrete size classes observed in variables in complex systems are evidence of these multiple regimes within complex systems, and the discontinuities between size classes indicate changes in scale.
C1 [Garmestani, Ahjond S.] US EPA, Washington, DC USA.
[Allen, Craig R.] Univ Nebraska, Lincoln, NE 68583 USA.
[Gunderson, Lance] Emory Univ, Atlanta, GA 30322 USA.
RP Garmestani, AS (reprint author), US EPA, Washington, DC USA.
FU James S. McDonnell Foundation 21st Century Research Award/Studying
Socio-ecological Systems; U. S. Geological Survey; Nebraska Game and
Parks Commission; University of Nebraska-Lincoln; U. S. Fish and
Wildlife Service; Wildlife Management Institute
FX Support was provided by the James S. McDonnell Foundation 21st Century
Research Award/Studying Socio-ecological Systems. The Nebraska
Cooperative Fish and Wildlife Research Unit is jointly supported by a
cooperative agreement between the U. S. Geological Survey, the Nebraska
Game and Parks Commission, the University of Nebraska-Lincoln, the U. S.
Fish and Wildlife Service, and the Wildlife Management Institute. This
manuscript was improved by comments from H. Cabezas, D. E. Campbell, and
M. E. Hopton.
NR 77
TC 27
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U1 5
U2 25
PU RESILIENCE ALLIANCE
PI WOLFVILLE
PA ACADIA UNIV, BIOLOGY DEPT, WOLFVILLE, NS B0P 1X0, CANADA
SN 1708-3087
J9 ECOL SOC
JI Ecol. Soc.
PD JUN
PY 2009
VL 14
IS 1
AR 15
PG 12
WC Ecology; Environmental Studies
SC Environmental Sciences & Ecology
GA 468TY
UT WOS:000267846300039
ER
PT J
AU Li, ZK
Lee, K
King, T
Kepkay, P
Boufadel, MC
Venosa, AD
AF Li, Zhengkai
Lee, Kenneth
King, Thomas
Kepkay, Paul
Boufadel, Michel C.
Venosa, Albert D.
TI Evaluating Chemical Dispersant Efficacy in an Experimental Wave Tank: 1,
Dispersant Effectiveness as a Function of Energy Dissipation Rate
SO ENVIRONMENTAL ENGINEERING SCIENCE
LA English
DT Article
DE oil spill; dispersant effectiveness; energy dissipation rate; breaking
waves
ID OIL DROPLET SIZE; BREAKING WAVES; TURBULENCE; SEA; SPILLS
AB Numerous laboratory test systems have been developed for the comparison of efficacy between various chemical oil dispersant formulations. However, for the assessment of chemical dispersant effectiveness under realistic sea state, test protocols are required to produce hydrodynamic conditions close to the mixing, transport, and dilution effects found in the natural environment. To this end, we have designed and constructed an experimental wave tank system capable of generating waves of different energy levels, ranging from regular non-breaking waves to plunging breakers. The hydrodynamics of these wave conditions were characterized using an autocorrelation function method applied to in situ velocity measurements. We report here an investigation of the effectiveness of two chemical dispersants (Corexit 9500 and SPC 1000) on two crude oils (weathered MESA and fresh ANS) under three different wave conditions in the wave tank operated in batch mode. Corexit 9500 dispersed approximately 75% of the weathered MESA and more than 90% of the fresh ANS crude, and SPC 1000 dispersed about 53 and 64%, respectively. Under control conditions (absence of chemical dispersant), only 10 to 20% of the crude oils were dispersed. Quantitative relationships were established between dispersant effectiveness and energy dissipation rate under the different simulated wave conditions. These relationships are essential for the development of accurate predictive models on dispersant effectiveness and operational guidelines for dispersant use.
C1 [Li, Zhengkai; Lee, Kenneth; King, Thomas; Kepkay, Paul] Fisheries & Oceans DFO Canada, Bedford Inst Oceanog, Ctr Offshore Oil & Gas Environ Res, Dartmouth, NS B2Y 4A2, Canada.
[Boufadel, Michel C.] Temple Univ, Dept Civil & Environm Engn, Philadelphia, PA 19122 USA.
[Venosa, Albert D.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Li, ZK (reprint author), Fisheries & Oceans DFO Canada, Bedford Inst Oceanog, Ctr Offshore Oil & Gas Environ Res, 1 Challenger Dr, Dartmouth, NS B2Y 4A2, Canada.
EM liz@dfo-mpo.gc.ca
FU Program of Energy Research and Development (PERD), U.S. EPA
[68-C-00-159]; NOAA/UNH Coastal Response Research Center (NOAA)
[NA04NOS4190063 UNH]
FX This research was funded by the Program of Energy Research and
Development (PERD), U.S. EPA ( contract No. 68-C-00-159), and NOAA/UNH
Coastal Response Research Center (NOAA Grant Number: NA04NOS4190063 UNH
Agreement No. 06-085). The authors wish to thank Susan Cobanli, Xiaowei
Ma, Brian Robinson, Peter Thamers, and William Yeung for their
contributions and logistic support. The findings, opinions, and
recommendations expressed in this report are those of the authors and do
not necessarily reflect those of the sponsors.
NR 31
TC 13
Z9 14
U1 1
U2 19
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1092-8758
J9 ENVIRON ENG SCI
JI Environ. Eng. Sci.
PD JUN
PY 2009
VL 26
IS 6
BP 1139
EP 1148
DI 10.1089/ees.2008.0377
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 446ZQ
UT WOS:000266161800014
ER
PT J
AU Nweke, OC
Sanders, WH
AF Nweke, Onyemaechi C.
Sanders, William H., III
TI Modern Environmental Health Hazards: A Public Health Issue of Increasing
Significance in Africa
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
DE Africa; environmental health; hazards
ID BLOOD LEAD LEVELS; CONTAMINATED HOUSE-DUST; INDOOR AIR-POLLUTION;
SOUTH-AFRICA; ORGANOCHLORINE PESTICIDES; DEVELOPING-COUNTRIES; LOURENS
RIVER; CHILDREN; EXPOSURE; MERCURY
AB OBJECTIVES: Traditional hazards such as poor sanitation currently account for most of Africa's environmentally related disease burden. However, with rapid development absent appropriate safeguards for environment and health, modern environmental health hazards (MEHHs) may emerge as critical contributors to the continent's disease burden. We review recent evidence of human exposure to and health effects from MEHHs, and their occurrence in environmental media and consumer products. Our purpose is to highlight the growing significance of these hazards as African countries experience urbanization, industrial growth, and development.
DATA SOURCES: We reviewed published epidemiologic, exposure, and environmental studies of chemical agents such as heavy metals and pesticides.
DATA SYNTHESIS: The body of evidence demonstrates ongoing environmental releases of MEHHs and human exposures sometimes at toxicologically relevant levels. Several sources of MEHHs in environmental media have been identified, including natural resource mining and processing and automobile exhaust. Biomonitoring studies provided direct evidence of human exposure to metals such as mercury and lead and pesticides such as p,p'-dichlorodiphenyltrichloroethane (DDT) and organophosphates. Land and water resource pollution and industrial air toxics are areas of significant data gaps, notwithstanding the presence of several emitting sources.
CONCLUSION: Unmitigated MEHH releases and human exposure have implications for Africa's disease burden. For Africans encumbered by conditions such as malnutrition that impair resilience to toxicologic challenges, the burden may be higher. A shift in public health policy toward accommodating the emerging diversity in Africa's environmental health issues is necessary to successfully alleviate the burden of avoidable ill health and premature death for all its communities now and in the future.
C1 [Nweke, Onyemaechi C.] US EPA, Off Policy Econ & Innovat, Washington, DC 20460 USA.
[Sanders, William H., III] US EPA, Off Childrens Hlth Protect & Environm Educ, Washington, DC 20460 USA.
RP Nweke, OC (reprint author), US EPA, Off Policy Econ & Innovat, MCI809T,1200 Penns Ave NW, Washington, DC 20460 USA.
EM nweke.onyemachi@epa.gov
NR 105
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U1 0
U2 31
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JUN
PY 2009
VL 117
IS 6
BP 863
EP 870
DI 10.1289/ehp.0800126
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 451HZ
UT WOS:000266462600019
PM 19590675
ER
PT J
AU Gilbert, ME
AF Gilbert, Mary E.
TI Developmental Perchlorate Exposure: Gilbert Responds
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Letter
C1 US EPA, Div Neurotoxicol, Res Triangle Pk, NC 27711 USA.
RP Gilbert, ME (reprint author), US EPA, Div Neurotoxicol, Res Triangle Pk, NC 27711 USA.
EM gilbert.mary@epa.gov
NR 3
TC 0
Z9 0
U1 3
U2 5
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JUN
PY 2009
VL 117
IS 6
BP A237
EP A238
DI 10.1289/ehp.0800532R
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 451HZ
UT WOS:000266462600004
ER
PT J
AU Henson-Ramsey, H
Levine, J
Kennedy-Stoskopf, S
Taylor, SK
Shea, D
Stoskopf, MK
AF Henson-Ramsey, Heather
Levine, Jay
Kennedy-Stoskopf, Suzanne
Taylor, Sharon K.
Shea, Damian
Stoskopf, Michael K.
TI Development of a Dynamic Pharmacokinetic Model to Estimate
Bioconcentration of Xenobiotics in Earthworms
SO ENVIRONMENTAL MODELING & ASSESSMENT
LA English
DT Article
DE Pharmacokinetic model; Xenobiotic; Earthworm; Soil
ID PERCUTANEOUS-ABSORPTION; LUMBRICUS-TERRESTRIS; ORGANIC-CHEMICALS; DERMAL
ROUTE; SOIL; EXPOSURE; MALATHION; BIOACCUMULATION; WATER;
2,4,6-TRINITROTOLUENE
AB A simple and dynamic pharmacokinetic model was developed to predict bioconcentration of organic contaminants in earthworms. The model was parameterized experimentally by placing Lumbricus terrestris in soil contaminated with 200 A mu g/cm(2) of malathion. The toxicokinetics of malathion uptake, depuration, and degradation in soil is measured. After parameterization, the model was able to accurately predict the bioconcentration factor of malathion at steady state. Sensitivity analyses were performed and the rate of absorption was determined to be the most sensitive parameter. Varying the rate of malathion elimination from earthworm tissues, malathion degradation, and the amount of malathion applied to the soil by 25-fold did not result in the bioconcentration of malathion. An increase in the rate of malathion absorption into earthworm tissues by 25-fold did result in bioconcentration. Previously published pharmacokinetic studies on xenobiotics with log K (ow) values ranging up to 8.05 were used to test the predictive capacity of the model. The model was able to predict from 83% to 105% of the experimentally derived bioconcentration factors.
C1 [Henson-Ramsey, Heather] Lewis Clark State Coll, Div Nat Sci, Lewiston, ID 83501 USA.
[Henson-Ramsey, Heather; Levine, Jay; Kennedy-Stoskopf, Suzanne; Stoskopf, Michael K.] N Carolina State Univ, Environm Med Consortium, Raleigh, NC 27607 USA.
[Kennedy-Stoskopf, Suzanne; Stoskopf, Michael K.] N Carolina State Univ, Dept Clin Sci, Raleigh, NC 27607 USA.
[Levine, Jay] N Carolina State Univ, Dept Populat Hlth & Pathobiol, Raleigh, NC 27607 USA.
[Taylor, Sharon K.] US EPA, Natl Ctr Environm Assessment Washington, DC Div, Res Triangle Pk, NC 27711 USA.
[Shea, Damian] N Carolina State Univ, Dept Zool, Raleigh, NC 27695 USA.
[Taylor, Sharon K.] US Fish & Wildlife Serv, Carlsbad Fish & Wildlife Off, Environm Contaminants Div, Carlsbad, CA 92011 USA.
RP Henson-Ramsey, H (reprint author), Lewis Clark State Coll, Div Nat Sci, 500 8th Ave, Lewiston, ID 83501 USA.
EM hlhenson@ncsu.edu
FU US Environmental Protection Agency (EPA) [R-83055101]
FX The US Environmental Protection Agency (EPA) through its Office of
Research and Development partially funded and collaborated in the
research described here under assistance agreement # R-83055101 to North
Carolina State University. The views expressed in this article are those
of the authors and do not necessarily reflect the view or policies of
the EPA.
NR 35
TC 0
Z9 0
U1 2
U2 14
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1420-2026
J9 ENVIRON MODEL ASSESS
JI Environ. Model. Assess.
PD JUN
PY 2009
VL 14
IS 3
BP 411
EP 418
DI 10.1007/s10666-007-9132-4
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 448KK
UT WOS:000266261300010
ER
PT J
AU Caruso, BS
Dawson, HE
AF Caruso, Brian S.
Dawson, Helen E.
TI Impacts of groundwater metal loads from bedrock fractures on water
quality of a mountain stream
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Mining; Metals; Bedrock; Fractured rocks; Groundwater monitoring;
Groundwater-surface water relations
ID ACID-MINE DRAINAGE; HYPORHEIC ZONE; ROCK AQUIFER; TRANSPORT; MODEL; USA;
EXCHANGE; COLORADO; REMOVAL; RANGE
AB Acid mine drainage and metal loads from hardrock mines to surface waters is a significant problem in the western USA and many parts of the world. Mines often occur in mountain environments with fractured bedrock aquifers that serve as pathways for metals transport to streams. This study evaluates impacts from current and potential future groundwater metal (Cd, Cu, and Zn) loads from fractures underlying the Gilt Edge Mine, South Dakota, on concentrations in Strawberry Creek using existing flow and water quality data and simple mixing/dilution mass balance models. Results showed that metal loads from bedrock fractures to the creek currently contribute < 1% of total loads. Even if background water quality is achieved upstream in Strawberry Creek, fracture metal loads would be < 5%. Fracture loads could increase substantially and cause stream water quality standards exceedances once groundwater with elevated metals concentrations in the aquifer matrix migrates to the fractures and discharges to the stream. Potential future metal loads from an upstream fracture would contribute a small proportion of the total load relative to current loads in the stream. Cd has the highest stream concentrations relative to standards. Even if all stream water was treated to remove 90% of the Cd, the standard would still not be achieved. At a fracture farther downstream, the Cd standard can only be met if the upstream water is treated achieving a 90% reduction in Cd concentrations and the median stream flow is maintained.
C1 [Caruso, Brian S.; Dawson, Helen E.] US Environm Protect Agcy Reg 8, Denver, CO 80202 USA.
RP Caruso, BS (reprint author), US Environm Protect Agcy Reg 8, 1595 Wynkoop St, Denver, CO 80202 USA.
EM caruso.brian@epa.gov
NR 42
TC 7
Z9 8
U1 3
U2 14
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD JUN
PY 2009
VL 153
IS 1-4
BP 405
EP 425
DI 10.1007/s10661-008-0367-6
PG 21
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 443NO
UT WOS:000265917200036
PM 18604589
ER
PT J
AU Wrenn, BA
Virkus, A
Mukherjee, B
Venosa, AD
AF Wrenn, B. A.
Virkus, A.
Mukherjee, B.
Venosa, A. D.
TI Dispersibility of crude oil in fresh water
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Oil spill; Dispersants; Fresh water; Hydrophilic-lipophilic balance;
Surfactants
ID DISPERSANTS; SURFACTANTS
AB The effects of surfactant composition on the ability of chemical dispersants to disperse crude oil in fresh water were investigated. The objective of this research was to determine whether effective fresh water dispersants can be designed in case this technology is ever considered for use in fresh water environments. Previous studies on the chemical dispersion of crude oil in fresh water neither identified the dispersants; that were investigated nor described the chemistry of the surfactants used. This information is necessary for developing a more fundamental understanding of chemical dispersion of crude oil at low salinity. Therefore, we evaluated the relationship between surfactant chemistry and dispersion effectiveness. We found that dispersants can be designed to drive an oil slick into the freshwater column with the same efficiency as in salt water as long as the hydrophilic-lipophilic balance is optimum. Published by Elsevier Ltd.
C1 [Venosa, A. D.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Wrenn, B. A.; Virkus, A.; Mukherjee, B.] Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA.
RP Venosa, AD (reprint author), US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM venosa.albert@epa.gov
FU U.S. Environmental Protection Agency National Risk Management Research
Laboratory's [EP06C000259]
FX This research was supported by the U.S. Environmental Protection Agency
National Risk Management Research Laboratory's Contract No. EP06C000259.
Mention of trade names or commercial products does not signify
endorsement by EPA. Views expressed by the authors are not necessarily
those of the U.S. EPA.
NR 19
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Z9 11
U1 2
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD JUN
PY 2009
VL 157
IS 6
BP 1807
EP 1814
DI 10.1016/j.envpol.2009.01.025
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 447KY
UT WOS:000266191200011
PM 19269075
ER
PT J
AU Henry, R
Norris, GA
Vedantham, R
Turner, JR
AF Henry, Ronald
Norris, Gary A.
Vedantham, Ram
Turner, Jay R.
TI Source Region Identification Using Kernel Smoothing
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID NONPARAMETRIC REGRESSION
AB As described in this paper, nonparametric wind regression is a source-to-receptor source apportionment model that can be used to identify and quantify the impact of possible source regions of pollutants as defined by wind direction sectors. It is described in detail with an example of its application to SO(2) data from East St. Louis, IL The model uses nonparametric kernel smoothing methods to apportion the observed average concentration of a pollutant to sectors defined by ranges of wind direction and speed. Formulas are given for the uncertainty of all of the important components of the model, and these are found to give nearly the same uncertainties as blocked bootstrap estimates of uncertainty. The model was applied to data for the first quarter (January, February, and March) of 2003, 2004, and 2005. The results for East St. Louis show that almost 50% of the average SO(2) concentration can be apportioned to two 30 degrees wide wind sectors containing a zinc smelter and a brewery; a nearby steel mill did not appear to have a significant impact on SO(2) during this period.
C1 [Henry, Ronald] Univ So Calif, Dept Civil & Environm Engn, Los Angeles, CA 90089 USA.
[Norris, Gary A.; Vedantham, Ram] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Turner, Jay R.] Washington Univ, Energy Environm & Chem Engn Dept, St Louis, MO 63130 USA.
RP Henry, R (reprint author), Univ So Calif, Dept Civil & Environm Engn, 3620 S Vermont Ave, Los Angeles, CA 90089 USA.
EM rhenry@usc.edu
RI Henry, Ronald/B-2497-2012
NR 5
TC 20
Z9 20
U1 3
U2 14
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JUN 1
PY 2009
VL 43
IS 11
BP 4090
EP 4097
DI 10.1021/es8011723
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 452NJ
UT WOS:000266546700021
PM 19569335
ER
PT J
AU Choi, H
Al-Abed, SR
Agarwal, S
AF Choi, Hyeok
Al-Abed, Souhail R.
Agarwal, Shirish
TI Effects of Aging and Oxidation of Palladized Iron Embedded in Activated
Carbon on the Dechlorination of 2-Chlorobiphenyl
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID GROUNDWATER TREATMENT PROCESSES; ZERO-VALENT IRON; TCE DECHLORINATION;
NANOSCALE PD/FE; GRANULAR IRON; ADSORPTION; SEDIMENT; BARRIER; PCBS;
HYDRODECHLORINATION
AB Reactive activated carbon (RAC) impregnated with palladized iron has been developed to effectively treat polychlorinated biphenyls (PCBs) in the environment by coupling adsorption and dechlorination of PCBs. In this study, we addressed the dechlorination reactivity and capacity of RAC toward aqueous 2-chlorobiphenyl (2-CIBP), and its aging and longevity under various oxidizing environments. RAC containing 14.4% Fe and 0.68% Pd used in this study could adsorb 122.6 mg 2-CIBP/g RAC, and dechlorinate 56.5 mg 2-CIBP/g RAC which corresponds to 12% (yield) of its estimated dechlorination capacity. Due to Fe(0) oxidation to form oxide passivating layers, Fe(2)O(3)/Fe(3)O(4) (oxide-water interface) and FeOOH/FeO (oxide-metal interface), RAC reactivity decreased progressively over aging under N(2) < H(2)O + N(2) < H(2)O + O(2) conditions. Considering nanoscale Fell Pd corrosion chemistry, the decline was quite slow at only 5.6%, 19.5%, and 32.5% over one year, respectively. Dissolved oxygen played a crucial role in enhancing 2-CIBP adsorption but inhibiting its dechlorination. The reactivity change could be explained with the properties of the aged RAC including surface area, Fe(0) content, and Fe species. During the aging and oxidation, the RAC showed limited dissolution of Fe and Pd. Finally, implementation issues regarding application of RAC system to contaminated sites are discussed.
C1 [Choi, Hyeok; Al-Abed, Souhail R.] US EPA, Natl Risk Managentent Res Lab, Cincinnati, OH 45268 USA.
[Agarwal, Shirish] Pegasus Tech Serv Inc, Cincinnati, OH 45221 USA.
RP Al-Abed, SR (reprint author), US EPA, Natl Risk Managentent Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM al-abed.souhail@epa.gov
FU National Risk Management Research Laboratory of U.S. Environmental
Protection Agency (EPA), Cincinnati, OH
FX This research was funded and conducted by the National Risk Management
Research Laboratory of U.S. Environmental Protection Agency (EPA),
Cincinnati, OH. This paper has not been subjected to internal policy
review of the U.S. EPA. Therefore, the research results do not
necessarily reflect the views of the agency or its policy. Mention of
trade names and commercial products does not constitute endorsement or
recommendation for use. We recognize the support of Dr. Gautham
Jegadeesan and Mr. Eric Graybill of Pegasus Technical Support Inc. for
ICP-AES analysis and GC/MS analysis, respectively. Donation of the
activated carbon from Norit Americas Inc. is appreciated.
NR 25
TC 24
Z9 25
U1 3
U2 37
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JUN 1
PY 2009
VL 43
IS 11
BP 4137
EP 4142
DI 10.1021/es803535b
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 452NJ
UT WOS:000266546700028
PM 19569342
ER
PT J
AU Arnot, JA
Meylan, W
Tunkel, J
Howard, PH
Mackay, D
Bonnell, M
Boethling, RS
AF Arnot, Jon A.
Meylan, William
Tunkel, Jay
Howard, Phil H.
Mackay, Don
Bonnell, Mark
Boethling, Robert S.
TI A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP FOR PREDICTING METABOLIC
BIOTRANSFORMATION RATES FOR ORGANIC CHEMICALS IN FISH
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Fish; Biotransformation; Bioaccumulation; Xenobiotic metabolism;
Quantitative structure-activity relationship
ID AQUATIC FOOD-WEBS; TROUT ONCORHYNCHUS-MYKISS; BIOACCUMULATION
PARAMETERS; AEROBIC BIODEGRADATION; DIETARY ACCUMULATION; LAKE-ONTARIO;
QSAR MODELS; BIOCONCENTRATION; FATE
AB An evaluated database of whole body in vivo biotransformation rate estimates in fish was used to develop a model for predicting the primary biotransformation half-lives of organic chemicals. The estimated biotransformation rates were converted to half-lives and divided into a model development set (n = 421) and an external validation set (n = 211) to test the model. The model uses molecular substructures similar to those of other biodegradation models. The biotransformation half-life predictions were calculated based on multiple linear regressions of development set data against counts of 57 molecular substructures, the octanol-water partition coefficient, and molar mass. The coefficient of determination (r(2)) for the development set was 0.82, the cross-validation (leave-one-out coefficient of determination, q(2)) was 0.75, and the mean absolute error (MAE) was 0.38 log units (factor of 2.4). Results for the external validation of the model using an independent test set were r(2) = 0.73 and MAE = 0.45 log units (factor of 2.8). For the development set, 68 and 95% of the predicted values were within a factor of 3 and a factor of 10 of the expected values, respectively. For the test (or validation) set, 63 and 90% of the predicted values were within a factor of 3 and a factor of 10 of the expected values, respectively. Reasons for discrepancies between model predictions and expected values are discussed and recommendations are made for improving the model. This model can predict biotransformation rate constants from chemical structure for screening level bioaccumulation hazard assessments, exposure and risk assessments, comparisons with other in vivo and in vitro estimates, and as a contribution to testing strategies that reduce animal usage.
C1 [Arnot, Jon A.; Mackay, Don] Trent Univ, Ctr Environm Modelling & Chem, Peterborough, ON K9H 7B8, Canada.
[Meylan, William; Tunkel, Jay; Howard, Phil H.] Syracuse Res Corp, Ctr Environm Sci, N Syracuse, NY 13212 USA.
[Bonnell, Mark] Environm Canada, Div Sci & Technol, Ottawa, ON K1A 0H3, Canada.
[Boethling, Robert S.] US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA.
RP Arnot, JA (reprint author), Trent Univ, Ctr Environm Modelling & Chem, 1600 W Bank Dr, Peterborough, ON K9H 7B8, Canada.
EM jonarnot@trentu.ca
FU Natural Sciences and Engineering Research Council of Canada; Environment
Canada; Health Canada; consortium of companies; International Life
Sciences Institute-Health and Environmental Sciences Institute; U.S.
Environmental Protection Agency (Office of Pollution Prevention and
Toxics)
FX The authors thank the Natural Sciences and Engineering Research Council
of Canada, Environment Canada, Health Canada, the consortium of
companies that support research at the Centre for Environmental
Modelling and Chemistry, and the International Life Sciences
Institute-Health and Environmental Sciences Institute for providing
financial support for this project. Support for modeling work performed
by Syracuse Research Corporation was provided by the U.S. Environmental
Protection Agency (Office of Pollution Prevention and Toxics) under a
subcontract with Versar, the prime contractor.
NR 36
TC 61
Z9 67
U1 2
U2 40
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD JUN
PY 2009
VL 28
IS 6
BP 1168
EP 1177
PG 10
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 449ZU
UT WOS:000266370700007
PM 19152232
ER
PT J
AU Shifman, MI
Yumul, RE
Laramore, C
Selzer, ME
AF Shifman, Michael I.
Yumul, Rae Eden
Laramore, Cindy
Selzer, Michael E.
TI Expression of the repulsive guidance molecule RGM and its receptor
neogenin after spinal cord injury in sea lamprey
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE Axonal guidance; Spinal cord regeneration; In situ hybridization; RGM;
Neogenin; Lamprey; Microglia
ID CENTRAL-NERVOUS-SYSTEM; AXONAL REGENERATION; NEURITE OUTGROWTH;
MICROGLIAL CELLS; ADULT-MOUSE; NEURONS; GROWTH; BRAIN; CNS; MYELIN
AB The sea lamprey recovers normal-appearing locomotion after spinal cord transection and its spinal axons regenerate selectively in their correct paths. However, among identified reticulospinal neurons some are consistently bad regenerators and only about 50% of severed reticulospinal axons regenerate through the site of injury. We previously suggested (Shifman, M. I., and Selzer, M. E., 2000a. Expression of netrin receptor UNC-5 in lamprey brain; modulation by spinal cord transection. Neurorehabilitation and Neural Repair 14, 49-58; Shifman, M. I., and Selzer, M. E., 2000b. In situ hybridization in wholemounted lamprey spinal cord: localization of netrin mRNA expression. journal of Neuroscience Methods 104, 19-25) that selective chemorepulsion might explain why some neurons are bad regenerators and others not. To explore the role of additional chemorepulsive axonal guidance molecules during regeneration, we examined the expression of the repulsive guidance molecule (RGM) and its receptor neogenin by in situ hybridization and quantitative PCR. RGM mRNA was expressed in the spinal cord, primarily in neurons of the lateral gray matter and in dorsal cells. Following spinal cord transection, RGM message was downregulated in neurons close (within 10 mm) to the transection at 2 and 4 weeks, although it was upregulated in reactive microglia at 2 weeks post-transection. Neogenin mRNA expression was unchanged in the brainstem after spinal cord transection, and among the identified reticulospinal neurons, was detected only in "bad regenerators", neurons that are known to regenerate well never expressed neogenin. The downregulation of RGM expression in neurons near the transection may increase the probability that regenerating axons will regenerate through the site of injury and entered caudal spinal cord. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Shifman, Michael I.; Yumul, Rae Eden; Laramore, Cindy; Selzer, Michael E.] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA.
[Selzer, Michael E.] Univ Penn, Sch Med, David Mahoney Inst Neurol Sci, Philadelphia, PA 19104 USA.
[Selzer, Michael E.] US EPA, Off Res & Dev, Dept Vet Affairs, Washington, DC 20420 USA.
RP Shifman, MI (reprint author), Univ Penn, Sch Med, Dept Neurol, 452 Stemmler Hall,36th St & Hamilton Walk, Philadelphia, PA 19104 USA.
EM mshifman@mail.med.upenn.edu
FU NIH [R01 NS38537]
FX We thank Dr. Farida Shaheen, PhD for help with quantitative PCR. This
work was supported by NIH grant R01 NS38537 to MES.
NR 63
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U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
J9 EXP NEUROL
JI Exp. Neurol.
PD JUN
PY 2009
VL 217
IS 2
BP 242
EP 251
DI 10.1016/j.expneurol.2009.02.011
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA 450GM
UT WOS:000266389000004
PM 19268666
ER
PT J
AU Ahlborn, GJ
Delker, DA
Roop, BC
Geter, DR
Allen, JW
DeAngelo, AB
Winnik, WM
AF Ahlborn, Gene J.
Delker, Don A.
Roop, Barbara C.
Geter, David R.
Allen, James W.
DeAngelo, Anthony B.
Winnik, Witold M.
TI Early alterations in protein and gene expression in rat kidney following
bromate exposure
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Bromate; Glycolysis; Mitochondria; Renal cell carcinoma; 2D-DIGE; Gene
expression
ID RENAL-CELL CARCINOMA; OXIDATIVE DNA-DAMAGE; POTASSIUM BROMATE; OXIDANT
INJURY; MITOCHONDRIAL BIOGENESIS; LIPID-PEROXIDATION; GAMMA-ENOLASE;
C-MYC; CANCER; STRESS
AB Bromate, a common disinfectant byproduct of drinking water ozonation, has been linked to human and animal renal toxicity, including renal cell carcinomas in multiple animal species. Here, we evaluate changes in protein and gene expression through two-dimensional difference gel electrophoresis (2D-DIGE) and Affymetrix arrays to identify potential modes of action involved in potassium bromate carcinogenicity. Male rats were exposed to potassium bromate in drinking water at concentrations of 0, 1, 20 and 400 ppm for two weeks. Differential expression of glycolytic proteins including enolase I (Eno 1), triosephosphate isomerase I (Tpi1) and glyceraldehyde-3-phosphate dehydrogenase (Gapdh) suggests that bromate toxicity is associated with changes in energy consumption and utilization in renal cells involving up-regulation of glycolytic processes that may be the result of altered mitochondrial function. Several alterations in glycolysis and mitochondrial gene transcripts were also observed to be consistent with this mode of action. These studies provide insight into early events in renal cell physiology altered by bromate exposure. Published by Elsevier Ltd.
C1 [Ahlborn, Gene J.; Delker, Don A.; Roop, Barbara C.; Geter, David R.; Allen, James W.; DeAngelo, Anthony B.; Winnik, Witold M.] US EPA, Natl Hlth & Environm Effects Res Lab, Div Environm Carcinogenesis, Res Triangle Pk, NC 27711 USA.
[Ahlborn, Gene J.] N Carolina State Univ, Coll Vet Med, Dept Mol Biomed Sci, Raleigh, NC 27606 USA.
RP Winnik, WM (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Div Environm Carcinogenesis, B143-06,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM winnik.witold@epa.gov
FU NCSU/EPA [CT826512010]
FX We gratefully acknowledge Drs. David DeMarini and Urmila Kodavanti for
their comments and assistance in reviewing this manuscript, and Oscar
Alzate at the Duke Neuroproteomic Center for assistance with the
2D-DIGE. This work was supported by a NCSU/EPA cooperative grant
(Agreement CT826512010). Disclaimer: The research described in this
article has been reviewed by the National Health and Environmental
Effects Research Laboratory, United States Environmental Protection
Agency, and approved for publication. Approval does not signify that the
contents necessarily reflect the views of the Agency, nor does the
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 53
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD JUN
PY 2009
VL 47
IS 6
BP 1154
EP 1160
DI 10.1016/j.fct.2009.02.003
PG 7
WC Food Science & Technology; Toxicology
SC Food Science & Technology; Toxicology
GA 450RK
UT WOS:000266418300018
PM 19425233
ER
PT J
AU Adams, PJ
Pandis, SN
Dawson, JP
Racherla, PN
AF Adams, P. J.
Pandis, S. N.
Dawson, J. P.
Racherla, P. N.
TI Air quality in a changing climate
SO GEOCHIMICA ET COSMOCHIMICA ACTA
LA English
DT Meeting Abstract
CT 19th Annual VM Goldschmidt Conference
CY JUN 21, 2009
CL Davos, SWITZERLAND
C1 [Adams, P. J.] Carnegie Mellon Univ, Ctr Atmospher Particle Studies, Pittsburgh, PA 15213 USA.
[Pandis, S. N.] Univ Patras, Dept Chem Engn, GR-26110 Patras, Greece.
[Dawson, J. P.] US EPA, Washington, DC 20460 USA.
[Racherla, P. N.] NASA, Goddard Inst Space Studies, New York, NY 10025 USA.
EM petera@andrew.cmu.edu
RI Pandis, Spyros/D-3680-2013; Adams, Peter/D-7134-2013
OI Adams, Peter/0000-0003-0041-058X
NR 0
TC 0
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U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0016-7037
J9 GEOCHIM COSMOCHIM AC
JI Geochim. Cosmochim. Acta
PD JUN
PY 2009
VL 73
IS 13
BP A9
EP A9
PG 1
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA 460YS
UT WOS:000267229900031
ER
PT J
AU Hering, JG
O'Day, PA
Ford, RG
He, YT
Bilgin, A
Reisinger, HJ
Burris, DR
AF Hering, Janet G.
O'Day, Peggy A.
Ford, Robert G.
He, Y. Thomas
Bilgin, Azra
Reisinger, H. James
Burris, David R.
TI MNA as a Remedy for Arsenic Mobilized by Anthropogenic Inputs of Organic
Carbon
SO GROUND WATER MONITORING AND REMEDIATION
LA English
DT Article
ID CCA-TREATED WOOD; NATURAL ATTENUATION PROCESSES; BACTERIAL SULFATE
REDUCTION; LANDFILL LEACHATE; REDOX CONDITIONS; FERRIC IRON;
DISSIMILATORY REDUCTION; MATTER MINERALIZATION; SYNTHETIC BIRNESSITE;
MICROBIAL REDUCTION
AB The potential application of monitored natural attenuation (MNA) as a remedy for ground water contaminated with arsenic (As) is examined for a subset of contaminated sites, specifically those where naturally occurring As has been mobilized due to localized anthropogenic organic carbon (OC) releases. This includes sites subject to petroleum releases, exposure to landfill leachates, and OC additions for biostimulation of reductive dechlorination of chlorinated solvents. The key characteristic of these sites is that, under conditions prevailing before the anthropogenic OC introduction, the naturally occurring As in the subsurface was not mobile and did not adversely affect ground water quality. This suggests that, in the far-field (where background conditions are (re) established), As may be sequestered upon contact of the contaminated ground water with either or both the (uncontaminated) ambient ground water and the background aquifer minerals. The observed extents of elevated concentrations (or "footprints") of As and other chemical species, such as dissolved OC and iron (Fe), and related parameters, such as redox potential (E-h) and dissolved oxygen, and their evolution over time can be used to assess the mobilization and sequestration of As and the potential feasibility of MNA as a remedial option. Ultimately, the capacity for As sequestration must be assessed in the context of the OC loading to the site, which may require "active" measures for source control. Monitoring is needed to confirm the continuing effectiveness of the MNA remedy or to indicate if contingency measures must be implemented.
C1 [Hering, Janet G.] Swiss Fed Inst Aquat Sci & Technol, CH-8600 Dubendorf, Switzerland.
[Hering, Janet G.; He, Y. Thomas; Bilgin, Azra] CALTECH, Dept Environm Sci & Engn, Pasadena, CA 91125 USA.
[O'Day, Peggy A.] Univ Calif, Sch Nat Sci, Merced, CA 95343 USA.
[Ford, Robert G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Reisinger, H. James] Integrated Sci & Technol Inc, Marietta, GA 30060 USA.
[Burris, David R.] Integrated Sci & Technol Inc, Panama City, FL 32401 USA.
RP Hering, JG (reprint author), Swiss Fed Inst Aquat Sci & Technol, Ueberlandstr 133, CH-8600 Dubendorf, Switzerland.
EM janet.hering@eawag.ch
RI Ford, Robert/N-4634-2014
OI Ford, Robert/0000-0002-9465-2282
FU Strategic Environmental Research and Development Program (SERDP)
[ER-1374]
FX Support provided by the Strategic Environmental Research and Development
Program (SERDP), project #ER-1374, is gratefully acknowledged.
NR 81
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U1 0
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1069-3629
EI 1745-6592
J9 GROUND WATER MONIT R
JI Ground Water Monit. Remediat.
PD SUM
PY 2009
VL 29
IS 3
BP 84
EP 92
DI 10.1111/j.1745-6592.2009.01242.x
PG 9
WC Water Resources
SC Water Resources
GA 479JM
UT WOS:000268655500009
ER
PT J
AU Schaeffer, BA
Kamykowski, D
Sinclair, G
Mckay, L
Milligan, EJ
AF Schaeffer, Blake A.
Kamykowski, Daniel
Sinclair, Geoff
McKay, Laurie
Milligan, Edward J.
TI Diel vertical migration thresholds of Karenia brevis (Dinophyceae)
SO HARMFUL ALGAE
LA English
DT Article
DE Carbon; Diel vertical migration; Dinoflagellate; Karenia brevis;
Nitrogen
ID DINOFLAGELLATE GYMNODINIUM BREVE; RED TIDE DINOFLAGELLATE;
POPULATION-DYNAMICS; CELL-CYCLE; PHYTOPLANKTON; SEPARATION; BUOYANCY;
NITROGEN; SAMPLES; LIPIDS
AB Light and nutrient availability change throughout dinoflagellate diel vertical migration (DVM) and/or with sub-population location in the water column along the west Florida shelf. Typically, the vertical depth of the shelf is greater than the distance a sub-population can vertically migrate during a diel cycle, limiting the ability of a sub-population to photosynthetically fix carbon toward the surface and access nutrients sub-surface. This project investigated changes of Karenia brevis (C.C. Davis) G. Hansen et Moestrup intracellular carbon, nitrogen, internal nitrate (iNO(3)) free amino acid (FAA), and total lipid concentrations in high-light, nitrate-replete (960 mu mol quanta m(-2) s(-1), 80 mu M NO3), and high-light, nitrate-reduced (960 mu mol quanta m(-2) s(-1), <5 mu M NO3) mesocosms. The nitrate-reduced mesocosm had a slowed cell division rate when compared to the nitrate-replete mesocosm. Minimum intracellular carbon, nitrogen, iNO(3), FAA, and total lipid concentrations during the largest surface sub-population aggregations led to the conclusion that daughter cells resulting from cell division received unequal shares of the parental resources and that this inequality influenced migration behavior. Nutrient reduced daughter cells were more strongly influenced by light and phototaxis for carbon production than their replete same cell division sister cells during vertical migration thus rapidly increasing the fulfillment of constituents through photosynthesis. Vertical migration was consistent with an optimization scheme based on threshold limits through utilization or formation of photosynthate. We propose a simplified conceptual model describing how K. brevis is transported along the benthos of the west Florida shelf from off-shore to on-shore. Dynamic carbon thresholds are also suggested for future DVM modeling efforts on K. brevis populations transported between nitrogen replete and nitrogen reduced environmental conditions. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Schaeffer, Blake A.] US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32563 USA.
[Kamykowski, Daniel; McKay, Laurie; Milligan, Edward J.] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Sinclair, Geoff] Louisiana Univ Marine Consortium, Chauvin, LA 70344 USA.
RP Schaeffer, BA (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32563 USA.
EM BlakeSchaeffer@gmail.com
FU U.S. National Oceanographic and Atmospheric Administration's
[NA160P1440]; U.S. Environmental Protection Agency's [R-82937001]
FX We thank Dr. W. Showers for use of a Lachat Quik Chem Autoanalyzer and
Dr. N. Blair for use of a Carlo Erba Nutrient analyzer. This paper is
based on research that has been supported in part by the U.S. National
Oceanographic and Atmospheric Administration's (NOAA) ECOHAB program
through grant NA160P1440 and by the U.S. Environmental Protection
Agency's (EPA) Science to Achieve Results (STAR) program through grant
R-82937001. The information in this document has been funded in part by
the U.S. Environmental Protection Agency. It has been subjected to
review by the National Health and Environmental Effects Research
Laboratory and approved for publication. Approval does not signify that
the contents reflect the views of the Agency, nor does mention of trade
names or commercial products constitute endorsement or recommendation
for use. This is contribution number 1352 from the Gulf Ecology
Division.[SS]
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U1 0
U2 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1568-9883
EI 1878-1470
J9 HARMFUL ALGAE
JI Harmful Algae
PD JUN
PY 2009
VL 8
IS 5
BP 692
EP 698
DI 10.1016/j.hal.2009.01.002
PG 7
WC Marine & Freshwater Biology
SC Marine & Freshwater Biology
GA 459ZW
UT WOS:000267153900009
ER
PT J
AU Floyd, HS
Chen, LC
Vallanat, B
Dreher, K
AF Floyd, Heather S.
Chen, Lung Chi
Vallanat, Beena
Dreher, Kevin
TI Fine ambient air particulate matter exposure induces molecular
alterations associated with vascular disease progression within plaques
of atherosclerotic susceptible mice
SO INHALATION TOXICOLOGY
LA English
DT Article
ID ACUTE ARTERIAL VASOCONSTRICTION; SMOOTH-MUSCLE CELLS; LONG-TERM
EXPOSURE; E-DEFICIENT MICE; GENE-EXPRESSION; SUBCHRONIC EXPOSURES;
APOE(-/-) MICE; PARTICLES CAPS; HEART-DISEASE; LUNG-CANCER
AB Epidemiology studies have reported associations between increased mortality and morbidity with exposure to particulate air pollution, particularly within individuals with preexisting cardiovascular disease (CVD). Clinical and toxicological studies have provided evidence that exposure to ambient air particulate matter (PM) impacts CVD by increasing plaque size. It is unclear whether PM-induced increased plaque size is associated with molecular disease progression. This study examines molecular profiles within plaques recovered from ApoE(-/-) mice exposed to concentrated ambient air particles (CAPs) to determine whether pulmonary deposition of PM contributes to molecular alterations leading to vascular disease progression. Laser capture microdissection was used to recover atherosclerotic plaques from ApoE(-/-) male mice exposed daily for 5 mo to filtered air or CAPs. Alterations in mRNA expression was assessed in microdissected plaques of CAPs-exposed and air controls using the Affymetrix microarray platform. Bioinformatic analysis indicated alterations in 611 genes: 395 genes downregulated and 216 genes upregulated. Gene ontology revealed CAPs-induced changes to inflammation, proliferation, cell cycle, hematological system, and cardiovascular pathways. Quantitative reverse-transcription polymerase chain reaction (qRT-PCR) verified microarray data also revealing gene expression alterations undetected by the microarray analysis, i.e., decreased expression of alpha-actin for smooth muscle cells, and increased expression of the macrophage marker Cd68 and of beta-actin. Comparison of CAPs-induced gene expression profiles demonstrated consistency with previously published gene expression profiles in the ApoE(-/-) mouse model and humans associated with plaque progression. These results indicate that exposure to fine PM induces molecular alterations associated with vascular disease progression and provides insight into potential biological pathways responsible for this effect.
C1 [Floyd, Heather S.; Vallanat, Beena; Dreher, Kevin] US Environm Protect Agcy, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Chen, Lung Chi] NYU, Sch Med, Nelson Inst Environm Med, Dept Environm Med, Tuxedo Pk, NY USA.
RP Dreher, K (reprint author), US Environm Protect Agcy, Natl Hlth & Environm Effects Res Lab, 109 TW Alexander Dr,MD-B143-01, Res Triangle Pk, NC 27711 USA.
EM dreher.kevin@epa.gov
RI Cjem, Lung-Chi/H-5030-2012;
OI Chen, Lung Chi/0000-0003-1154-2107
FU US. EPA-NCSU Cooperative Training Agreement [CT 833235-01-0]; EPA PM
Center [R827351]; NIH [R01ES015495]; NIEHS Center [ES00260]
FX The research described in this article has been reviewed by the National
Health and Environmental Effects Research Laboratory, U.S. Environmental
Protection Agency, and approved for publication. Approval does not
signify that the contents necessarily reflect the views and policies of
the agency; nor does the mention of trade names or commercial products
constitute endorsement or recommendation for use.
NR 59
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U1 0
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 0895-8378
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD JUN
PY 2009
VL 21
IS 5-7
BP 394
EP 403
DI 10.1080/08958370802317745
PG 10
WC Toxicology
SC Toxicology
GA 478GX
UT WOS:000268576900002
PM 19496694
ER
PT J
AU Garcia, GJM
Schroeter, JD
Segal, RA
Stanek, J
Foureman, GL
Kimbell, JS
AF Garcia, Guilherme J. M.
Schroeter, Jeffry D.
Segal, Rebecca A.
Stanek, John
Foureman, Gary L.
Kimbell, Julia S.
TI Dosimetry of nasal uptake of water-soluble and reactive gases: A first
study of interhuman variability
SO INHALATION TOXICOLOGY
LA English
DT Article
ID COMPUTATIONAL FLUID-DYNAMICS; AIR-FLOW PATTERNS; NUMERICAL-SIMULATION;
INHALED FORMALDEHYDE; RISK-ASSESSMENT; PARTICLE DEPOSITION; BREATHING
PATTERN; HYDROGEN-SULFIDE; HUMAN NOSE; BODY-SIZE
AB Certain inhaled chemicals, such as reactive, water-soluble gases, are readily absorbed by the nasal mucosa upon inhalation and may cause damage to the nasal epithelium. Comparisons of the spatial distribution of nasal lesions in laboratory animals exposed to formaldehyde with gas uptake rates predicted by computational models reveal that lesions usually occur in regions of the susceptible epithelium where gas absorption is highest. Since the uptake patterns are influenced by air currents in the nose, interindividual variability in nasal anatomy and ventilation rates due to age, body size, and gender will affect the patterns of gas absorption in humans, potentially putting some age groups at higher risk when exposed to toxic gases. In this study, interhuman variability in the nasal dosimetry of reactive, water-soluble gases was investigated by means of computational fluid dynamics (CFD) models in 5 adults and 2 children, aged 7 and 8 years old. Airflow patterns were investigated for allometrically scaled inhalation rates corresponding to resting breathing. The spatial distribution of uptake at the airway walls was predicted to be nonuniform, with most of the gas being absorbed in the anterior portion of the nasal passages. Under the conditions of these simulations, interhuman variability in dose to the whole nose (mass per time per nasal surface area) due to differences in anatomy and ventilation was predicted to be 1.6-fold among the 7 individuals studied. Children and adults displayed very similar patterns of nasal gas uptake; no significant differences were noted between the two age groups.
C1 [Garcia, Guilherme J. M.; Schroeter, Jeffry D.; Kimbell, Julia S.] Hamner Inst Hlth Sci, Res Triangle Pk, NC 27709 USA.
[Segal, Rebecca A.] Virginia Commonwealth Univ, Richmond, VA USA.
[Stanek, John; Foureman, Gary L.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
RP Kimbell, JS (reprint author), Hamner Inst Hlth Sci, 6 Davis Dr,POB 12137, Res Triangle Pk, NC 27709 USA.
EM kimbell@thehamner.org
RI Garcia, Guilherme/J-9555-2013
FU U.S. EPA [EP05C000009, EP06C000405]; American Chemistry Council
FX The views expressed in this article are those of the authors and do not
necessarily reflect the views or policies of the U.S. Environmental
Protection Agency.
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PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 0895-8378
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD JUN
PY 2009
VL 21
IS 5-7
BP 607
EP 618
DI 10.1080/08958370802320186
PG 12
WC Toxicology
SC Toxicology
GA 478GX
UT WOS:000268576900022
PM 19459775
ER
PT J
AU Yang, YJ
Haught, RC
Goodrich, JA
AF Yang, Y. Jeffrey
Haught, Roy C.
Goodrich, James A.
TI Real-time contaminant detection and classification in a drinking water
pipe using conventional water quality sensors: Techniques and
experimental results
SO JOURNAL OF ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Contaminant detection; Contaminant identification; Drinking water
security; Detection threshold; Adaptive monitoring; Water quality
sensors
ID DISTRIBUTION-SYSTEMS; CHLORINE RESIDUALS; AGENTS; MODEL;
PHARMACEUTICALS; BIOTERRORISM; DEGRADATION; GLYPHOSATE; MECHANISM;
TERRORISM
AB Accurate detection and identification of natural or intentional contamination events in a drinking water pipe is critical to drinking water supply security and health risk management. To use conventional water quality sensors for the purpose, we have explored a real-time event adaptive detection, identification and warning (READiw) methodology and examined it using pilot-scale pipe flow experiments of 11 chemical and biological contaminants each at three concentration levels. The tested contaminants include pesticide and herbicides (aldicarb, glyphosate and dicamba), alkaloids (nicotine and colchicine), E coli in terrific broth, biological growth media (nutrient broth, terrific broth, tryptic soy broth), and inorganic chemical compounds (mercuric chloride and potassium ferricyanide). First, through adaptive transcontaminant signals were enhanced and background noise was reduced formation of the sensor outputs, in time-series plots leading to detection and identification of all simulated contamination events. The improved sensor detection threshold was 0.1% of the background for pH and oxidation-reduction potential (ORP), 0.9% for free chlorine, 1.6% for total chlorine, and 0.9% for chloride. Second, the relative changes calculated from adaptively transformed residual chlorine measurements were quantitatively related to contaminant-chlorine reactivity in drinking water. We have shown that based on these kinetic and chemical differences, the tested contaminants were distinguishable in forensic discrimination diagrams made of adaptively transformed sensor measurements. Published by Elsevier Ltd.
C1 [Yang, Y. Jeffrey; Haught, Roy C.; Goodrich, James A.] US EPA, Natl Risk Management Res Lab, Water Supply & Water Resources Div, Cincinnati, OH 45268 USA.
RP Yang, YJ (reprint author), US EPA, Natl Risk Management Res Lab, Water Supply & Water Resources Div, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM yang.jeff@epa.gov
FU U.S. EPA's National Homeland Security Research Center (NHSRC)
FX The authors wish to acknowledge the contribution from the following
individuals: John Hall and Dr. Jeff Szabo of U.S. EPA's National
Homeland Security Research Center (NHSRC) and Greg Meiners of Shaw
Environmental for experimental testing, Dr. Regan Murray, Robert Janke,
Dr. A.Joel Allen, John Hall and Dr.Jeff Szabo, all of U.S. EPA, for
their manuscript review and comments. Peer review by 6 anonymous
reviewers, and financial support to this project by U.S. EPA National
Homeland Security Research Center and U.S. EPA National Risk Management
Research Laboratory are acknowledged. Conclusions and opinions presented
in this paper are those of the authors, and not necessarily represent
the position of the U.S. EPA. Mention of commercial products, trade
names or services in the paper does not convey, and should not be
interpreted as conveying, official EPA approval, endorsement, or
recommendation.
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U1 7
U2 48
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0301-4797
EI 1095-8630
J9 J ENVIRON MANAGE
JI J. Environ. Manage.
PD JUN
PY 2009
VL 90
IS 8
BP 2494
EP 2506
DI 10.1016/j.jenvman.2009.01.021
PG 13
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 463ST
UT WOS:000267453100018
ER
PT J
AU Lu, HF
Campbell, DE
AF Lu, Hongfang
Campbell, Daniel E.
TI Ecological and economic dynamics of the Shunde agricultural system under
China's small city development strategy
SO JOURNAL OF ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Emergy evaluation; Industrialization of agriculture; Productivity of
labor; Regional self-sufficiency; Ecosystem services
ID EMERGY EVALUATION; POULTRY PRODUCTION; SUSTAINABILITY; MANAGEMENT;
INDEXES
AB The agricultural and industrial development of small cities is the primary environmental management strategy employed to make full use of extra labor in the rural areas of China. The ecological and economic consequences of this development strategy will affect over 100 million people and change the organization of the Chinese landscape. In this study, we examined the agricultural development of Shunde, a small city in Guangdong Province, over the period 1978 until 2000. Our analysis of the ecological and economic dynamics of the agricultural system revealed the dominant role of labor in the intensification of agricultural production, even though the use of fuels, fertilizers and machines also increased during this time. The Shunde agricultural system was examined from both biophysical or donor-based and human utility or receiver-based perspectives, using emergy and economic methods, respectively. After 22 years of urbanization, the Shunde agricultural system was still able to fill 96% of the local demand for agricultural products using only 6% of its total yield compared to using 14% of the total yield in 1978. Aquaculture developed quickly during the study period as grain production decreased. In 2000, the production of fish, pork, and vegetables accounted for 92% of the total emergy output of the system; however, the emergy buying power of the money received in exchange was lower than the emergy contained in the products exported. The excess emergy exported is the basis for a high quality diet delivered to city dwellers at a relatively low price. In the 1980s, the productivity of both land and labor increased; but after 1992 the productivity of labor decreased, causing the efficiency of the whole agricultural system to decrease. We recommend that processing plants be established for the main agricultural products of Shunde to decrease the emergy loss in trading and to increase employment. The effect of including monetized ecosystem services in the balance between the emergy delivered to the markets in agricultural products and the emergy buying power of the money received was to decrease the emergy gained by the Shunde agricultural system. Published by Elsevier Ltd.
C1 [Lu, Hongfang] Chinese Acad Sci, S China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China.
[Campbell, Daniel E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Campbell, DE (reprint author), Chinese Acad Sci, S China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China.
EM campbell.dan@epa.gov
FU National Science Foundation of China [30600072]; Chinese Academy of
Sciences; Natural Science Foundation of Guangdong [05006766,
20061320730001]; US EPA [AED-07-073]; National Health and Environmental
Effects Research Laboratory, Atlantic Ecology Division
FX We thank Mr. Jinwen Ma and Yongbiao Lin for help with investigation and
data collection, Drs. Tingting Cai, John Kiddon, Edward Dettmann, Glen
Thursby, Mr. Thomas Olsen, and two anonymous reviewers for helpful
reviews of the manuscript. Jinping Zhang provided the map in Fig. I.This
study was supported by Projects of the National Science Foundation of
China (30600072), the Director's Award of the Chinese Academy of
Sciences, and the Natural Science Foundation of Guangdong (05006766,
20061320730001). This paper is also contribution number AED-07-073 of
the US EPA, Office of Research and Development, National Health and
Environmental Effects Research Laboratory, Atlantic Ecology Division.
NR 46
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U1 3
U2 29
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0301-4797
EI 1095-8630
J9 J ENVIRON MANAGE
JI J. Environ. Manage.
PD JUN
PY 2009
VL 90
IS 8
BP 2589
EP 2600
DI 10.1016/j.jenvman.2009.01.019
PG 12
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 463ST
UT WOS:000267453100029
PM 19246149
ER
PT J
AU Barbiero, RP
Bunnell, DB
Rockwell, DC
Tuchman, ML
AF Barbiero, Richard P.
Bunnell, David B.
Rockwell, David C.
Tuchman, Marc L.
TI Recent increases in the large glacial-relict calanoid Limnocalanus
macrurus in Lake Michigan
SO JOURNAL OF GREAT LAKES RESEARCH
LA English
DT Article
DE Limnocalanus; Transparency; Extinction coefficient; Planktivorous fish
ID LAURENTIAN GREAT-LAKES; WATER SURVEILLANCE PROGRAM; ZOOPLANKTON
COMMUNITY; PREY SELECTION; DYNAMICS; FISH; PREDATION; TRENDS;
PHYTOPLANKTON; RECRUITMENT
AB Since 2004, population density of the large hypolimnetic calanoid Limnocalanus macrurus Sars. has increased dramatically in Lake Michigan. The average summer biomass of this species between 2004 and 2006 was roughly three times that of the period 1984-2003, and at levels unprecedented in our 22-year dataset, making L. macrurus the dominant zooplankter in the lake in terms of biomass. These increases have been accentuated by coincident population declines of the main daphnid, Daphnia mendotae, in the lake with the result that in 2006, L. macrurus accounted for 75% and 50% of the large (>0.9 mm) crustacean biomass in the northern and southern basins of Lake Michigan, respectively. The increases in L. macrurus Populations have closely coincided with equally dramatic increases in summer water clarity. Recent extinction coefficients are among the lowest recorded for the lake, and deepening light penetration has permitted increases in the size of the deep chlorophyll layer. In addition, planktivorous fish Populations have declined coincidently with the increases in L. macrurus. It seems likely that all increase in sub-epilimnetic production has resulted in increased food resources for the deep-living L. macrurus, while low planktivore abundances have reduced predation loss, permitting L. macrurus to respond to these increases in sub-epilimnetic production. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Barbiero, Richard P.] Loyola Univ, Chicago, IL 60660 USA.
[Barbiero, Richard P.] Comp Sci Corp, Chicago, IL 60660 USA.
[Bunnell, David B.] US Geol Survey, Great Lakes Sci Ctr, Ann Arbor, MI 48105 USA.
[Rockwell, David C.; Tuchman, Marc L.] US EPA, Lakes Natl Program Off, Chicago, IL 60604 USA.
RP Barbiero, RP (reprint author), Loyola Univ, 1359 W Elmdale Ave Suite 2, Chicago, IL 60660 USA.
EM gloeotri@sbcglobal.net; dbunnell@usgs.gov; rockwell.david@glnpo.gov;
tuchman.marc@glnpo.gov
OI Bunnell, David/0000-0003-3521-7747
FU U.S. Environmental Protection Agency [EP-W-06-046]
FX K Arendes, D. DiBartolomeo and A. Ahktar provided excellent data entry
support. J.L. Doering and N.C. Tuchman of Loyola University, Chicago,
were helpful in providing computer facilities for processing of
historical data. T. Desorcie assisted in preparation of Fig. 1. The
information in this document has been funded by the U.S. Environmental
Protection Agency under contract number EP-W-06-046 to Computer Sciences
Corporation. It has been subjected to Agency review and approved for
publication. This article is Contribution 1517 of the USGS Great Lakes
Science Center.
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U1 0
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0380-1330
J9 J GREAT LAKES RES
JI J. Gt. Lakes Res.
PD JUN
PY 2009
VL 35
IS 2
BP 285
EP 292
DI 10.1016/j.jglr.2008.12.006
PG 8
WC Environmental Sciences; Limnology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 460DH
UT WOS:000267167400014
ER
PT J
AU Pasula, R
Britigan, BE
Turner, J
Martin, WJ
AF Pasula, Rajamouli
Britigan, Bradley E.
Turner, Joanne
Martin, William J., II
TI Airway Delivery of Silica Increases Susceptibility to Mycobacterial
Infection in Mice: Potential Role of Repopulating Macrophages
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID AFRICAN GOLD MINERS; INTERFERON-GAMMA PRODUCTION; PHAGOSOME-LYSOSOME
FUSION; THORACIC LYMPH-NODES; ALVEOLAR MACROPHAGES; PULMONARY
TUBERCULOSIS; IFN-GAMMA; DEFICIENT PATIENTS; LUNG FIBROSIS; MURINE MODEL
AB Silica exposure results in an increased lifelong risk of developing mycobacterial pulmonary infections. To date, there are no animal models that replicate this finding to permit assessment of the mechanisms underlying susceptibility to mycobacterial infection. To test the hypothesis that prior silica exposure increases risk of mycobacterial infection, we intratracheally (I.T.) administered silica, a control dust (Al(2)O(3)) or saline into mechanically ventilated C57BL/6 mice. Later, the mice received Mycobacterium avium or Mycobacterium tuberculosis I.T. Mice were sacrificed at defined time points and mycobacteria in lung homogenates were quantified. M. avium or M. tuberculosis infection was markedly increased in silica-exposed mice compared with mice exposed to either Al(2)O(3) or saline beginning 3 wk after silica exposure. Similarly, lung sections from silica-exposed mice had many more acid fast bacilli(+) (AFB(+)) organisms than from control mice. Alveolar macrophages (AMs) from bronchoalveolar lavage of silica-exposed mice also revealed a higher number of mycobacteria compared with mice treated with Al(2)O(3) or saline. In addition, passive transfer of AMs from silica-exposed mice to control mice increased M. tuberculosis susceptibility. These results indicate that silica exposure converts mycobacteria-resistant mice into mycobacteria-susceptible mice via a process that likely involves a new population of AMs that are more susceptible to mycobacterial infection. The Journal of Immunology, 2009, 182: 7102-7109.
C1 [Pasula, Rajamouli; Britigan, Bradley E.] Univ Cincinnati, Dept Internal Med, Cincinnati, OH 45267 USA.
[Britigan, Bradley E.] Vet Affairs Med Ctr, Cincinnati, OH 45267 USA.
[Turner, Joanne] Ohio State Univ Hosp, Dept Internal Med, Div Infect Dis, Ctr Microbial Interface Biol, Columbus, OH 43210 USA.
[Martin, William J., II] Natl Inst Environm Hlth Sci, NIH, Res Triangle Pk, NC 27709 USA.
RP Pasula, R (reprint author), Univ Cincinnati, Dept Internal Med, POB 670557, Cincinnati, OH 45267 USA.
EM pasular@ucmail.uc.edu
RI Turner, Joanne/E-4219-2011; Turner, Joanne/F-4118-2015
FU National Institutes of Health [R01 HL076955]; Veterans Affairs Merit
Review Award
FX This work was supported by National Institutes of Health Grant R01
HL076955 (to R.P. and B.E.B.) and Veterans Affairs Merit Review Award
(to B.E.B.).
NR 72
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Z9 7
U1 0
U2 1
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD JUN 1
PY 2009
VL 182
IS 11
BP 7102
EP 7109
DI 10.4049/jimmunol.0803642
PG 8
WC Immunology
SC Immunology
GA 448JG
UT WOS:000266258300054
PM 19454707
ER
PT J
AU Chen, C
Li, GL
Liao, WM
Wu, J
Liu, L
Ma, D
Zhou, JF
Elbekai, RH
Edin, ML
Zeldin, DC
Wang, DW
AF Chen, Chen
Li, Guiling
Liao, Wanmin
Wu, Jun
Liu, Liu
Ma, Ding
Zhou, Jianfeng
Elbekai, Reem H.
Edin, Matthew L.
Zeldin, Darryl C.
Wang, Dao Wen
TI Selective Inhibitors of CYP2J2 Related to Terfenadine Exhibit Strong
Activity against Human Cancers in Vitro and in Vivo
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID ARACHIDONIC-ACID EPOXYGENASE; HUMAN CYTOCHROME-P450 2J2; ACTIVATED
PROTEIN-KINASE; HUMAN-MELANOMA CELLS; SIGNALING PATHWAYS;
MOLECULAR-CLONING; EXPRESSION; METABOLISM; APOPTOSIS; PROMOTES
AB The cytochrome P450 epoxygenase, CYP2J2, converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs). We found recently that this enzyme is dramatically up-regulated in a variety of established human carcinoma cell lines and in human cancerous tissue and promotes the neoplastic phenotype. In the present study, we tested the hypothesis that specific inhibitors of CYP2J2 related to the drug terfenadine are effective antitumor agents. Four of these inhibitors (compounds 4, 5, 11, and 26) were tested for effectiveness in vitro and in vivo. In Tca-8113 cells, the CYP2J2 inhibitors decreased EET production by approximately 60%, whereas they had no effect on CYP2J2 mRNA or protein expression. Compound 26 inhibited the proliferation of human tumor cells, reduced their ability to adhere, invade, and migrate, and attenuated activation of epithelial growth factor receptor signal and kinases and phosphatidylinositol 3 kinase/Akt pathways. Inhibition of CYP2J2 also significantly potentiated human tumor cell apoptosis and caused a corresponding increase in caspase-3 activity and change in expression of apoptosis-related proteins Bax and Bcl-2. In murine xenograft models using MDA-MB-435 cells, treatment with compound 26 significantly repressed tumor growth, decreased lung metastasis, and was associated with increased expression of the anticancer genes CD82 and nm23, without causing toxicity. These data suggest that CYP2J2 inhibitors hold significant promise for use in treatment of neoplastic diseases.
C1 [Chen, Chen; Li, Guiling; Liao, Wanmin; Wu, Jun; Liu, Liu; Ma, Ding; Zhou, Jianfeng; Wang, Dao Wen] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Internal Med, Tongji Hosp, Wuhan 430030, Peoples R China.
[Chen, Chen; Li, Guiling; Liao, Wanmin; Wu, Jun; Liu, Liu; Ma, Ding; Zhou, Jianfeng; Wang, Dao Wen] Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Hypertens, Tongji Hosp, Wuhan 430030, Peoples R China.
[Elbekai, Reem H.; Edin, Matthew L.; Zeldin, Darryl C.] Natl Inst Environm Hlth Sci, Div Intramural Res, NIH, Res Triangle Pk, NC USA.
RP Wang, DW (reprint author), Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Internal Med, Tongji Hosp, 1095 Jiefang Ave, Wuhan 430030, Peoples R China.
EM dwwang@tjh.tjmu.edu.cn
OI Edin, Matthew/0000-0002-7042-500X
FU China Natural Science Foundation Committee [30540087, 30430320];
International Collaboration Project [2005DFA30880]; 973 Program
[2007CB512004, 2002CB513107]; National Institutes of Health National
Institute of Environmental Health Sciences [Z01 ES025034]
FX This work was supported in part by the China Natural Science Foundation
Committee [Grants 30540087, 30430320]; the International Collaboration
Project [Grant 2005DFA30880]; the 973 Program [Grants 2007CB512004,
2002CB513107]; and by the Intramural Research program of the National
Institutes of Health National Institute of Environmental Health Sciences
[Grant Z01 ES025034].
NR 31
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U1 2
U2 13
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD JUN
PY 2009
VL 329
IS 3
BP 908
EP 918
DI 10.1124/jpet.109.152017
PG 11
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 447QV
UT WOS:000266207800008
PM 19289568
ER
PT J
AU Lee, JY
Keener, TC
Yang, YJ
AF Lee, Joo-Youp
Keener, Tim C.
Yang, Y. Jeffery
TI Potential Flue Gas Impurities in Carbon Dioxide Streams Separated from
Coal-Fired Power Plants
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID CO2 CAPTURE TECHNOLOGY; CLIMATE-CHANGE; GEOLOGICAL STORAGE; ABANDONED
WELL; SITE SELECTION; SEQUESTRATION; MONOETHANOLAMINE; ABSORPTION;
DEGRADATION; SIMULATION
AB For geological sequestration of carbon dioxide (CO(2)) separated from pulverized coal combustion flue gas, it is necessary to adequately evaluate the potential impacts of flue gas impurities on groundwater aquifers in the case of the CO(2) leakage from its storage sites. This study estimated the flue gas impurities to be included in the CO(2) stream separated from a CO(2) control unit for a different combination of air pollution control devices and different flue gas compositions. Specifically, the levels of acid gases and mercury vapor were estimated for the monoethanolamine (MEA)-based absorption process on the basis of published performance parameters of existing systems. Among the flue gas constituents considered, Sulfur dioxide (SO(2)) is known to have the most adverse impact on MEA absorption. When a flue gas contains 3000 parts per million by volume (ppmv) SO(2) and a wet flue gas desulfurization system achieves its 95% removal, approximately 2400 parts per million by weight (ppmw) SO(2) could be included in the separated CO(2) stream. In addition, the estimated concentration level was reduced to as low as 135 ppmw for the SO(2) of less than 10 ppmv in the flue gas entering the MEA unit. Furthermore, heat-stable salt formation could further reduce the SO(2) concentration below 40 ppmw in the separated CO(2) stream. In this study, it is realized that the formation rates of heat-stable salts in MEA solution are not readily available in the literature and are critical to estimating the levels and compositions of flue gas impurities in sequestered CO(2) streams. In addition to SO(2), mercury, and other impurities in separated CO(2) streams could vary depending on pollutant removal at the power plants and impose potential impacts on groundwater. Such a variation and related process control in the upstream management of carbon separation have implications for groundwater protection at carbon sequestration sites and warrant necessary considerations in overall sequestration planning, engineering, and management.
C1 [Lee, Joo-Youp] Univ Cincinnati, Dept Chem & Mat Engn, Cincinnati, OH 45221 USA.
[Keener, Tim C.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
[Yang, Y. Jeffery] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Lee, JY (reprint author), Univ Cincinnati, Dept Chem & Mat Engn, Mail Locat 0012, Cincinnati, OH 45221 USA.
EM joo.lee@uc.edu
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U1 0
U2 18
PU AIR & WASTE MANAGEMENT ASSOC
PI PITTSBURGH
PA ONE GATEWAY CENTER, THIRD FL, PITTSBURGH, PA 15222 USA
SN 1047-3289
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PD JUN
PY 2009
VL 59
IS 6
BP 725
EP 732
DI 10.3155/1047-3289.59.6.725
PG 8
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA 455WB
UT WOS:000266797400008
PM 19603740
ER
PT J
AU Teng, Q
Huang, WL
Collette, TW
Ekman, DR
Tan, C
AF Teng, Quincy
Huang, Wenlin
Collette, Timothy W.
Ekman, Drew R.
Tan, Chalet
TI A direct cell quenching method for cell-culture based metabolomics
SO METABOLOMICS
LA English
DT Article
DE Cellular metabolite; Cell-culture based metabolomics; Direct cell
quenching; Metabolite profiling of breast cancer cells
ID MULTIPLE-QUANTUM NMR; BREAST-CANCER; CHEMICAL-SHIFTS; SPECTROSCOPY; H-1;
METABOLITES; IDENTIFICATION; YEAST
AB A crucial step in metabolomic analysis of cellular extracts is the cell quenching process. The conventional method first uses trypsin to detach cells from their growth surface. This inevitably changes the profile of cellular metabolites since the detachment of cells from the extracellular matrix alters their physiology. This conventional method also includes time consuming wash/centrifuge steps after trypsinization, but prior to quenching cell activity. During this time, a considerable portion of intracellular metabolites are lost, rendering the conventional method less than ideal for application to metabolomics. We report here a novel sample preparation method for metabolomics applications using adherent mammalian cells, which eliminates the time consumption and physiological stress of the trypsinization and wash/centrifuge steps. This new method was evaluated in the study of metabolic changes caused by 17 alpha-ethynylestradiol (EE2) in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 human breast cancer cell lines using NMR spectroscopy. The results demonstrated that our direct cell quenching method is rapid, effective, and exhibits greater metabolite retention, providing an increase of approximately a factor of 50 compared to the conventional method.
C1 [Teng, Quincy; Huang, Wenlin; Collette, Timothy W.; Ekman, Drew R.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
[Tan, Chalet] Mercer Univ, Dept Pharmaceut Sci, Coll Pharm & Hlth Sci, Atlanta, GA 30341 USA.
RP Teng, Q (reprint author), US EPA, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM teng.quincy@epa.gov; huang.wenlin@epa.gov; collette.tim@epa.gov;
ekman.drew@epa.gov; tan_c@mercer.edu
FU U.S. EPA Office of Research and Development; U.S. EPA Office of Science
Council Policy
FX This work was funded in part through the Computational Toxicology
Program of the U.S. EPA Office of Research and Development and the U.S.
EPA Office of Science Council Policy. It has been subjected to review by
the National Exposure Research Laboratory and approved for publication.
Approval does not signify that the contents reflect the views of the
Agency, nor does mention of trade names or commercial products
constitute endorsement or recommendation for use.
NR 37
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U1 5
U2 61
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1573-3882
J9 METABOLOMICS
JI Metabolomics
PD JUN
PY 2009
VL 5
IS 2
BP 199
EP 208
DI 10.1007/s11306-008-0137-z
PG 10
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 440FS
UT WOS:000265686800004
ER
PT J
AU Mazan, MR
Svatek, J
Maranda, L
Christiani, D
Ghio, A
Nadeau, J
Hoffman, AM
AF Mazan, Melissa R.
Svatek, Jessica
Maranda, Louise
Christiani, David
Ghio, Andrew
Nadeau, Jenifer
Hoffman, Andrew M.
TI Questionnaire assessment of airway disease symptoms in equine barn
personnel
SO OCCUPATIONAL MEDICINE-OXFORD
LA English
DT Article
DE Airway disease; asthma; barn; horse; IAD; organic dust
ID OBSTRUCTIVE PULMONARY-DISEASE; RESPIRATORY SYMPTOMS; LUNG-FUNCTION; DUST
EXPOSURE; AIRBORNE DUST; RISK-FACTORS; COTTON DUST; HORSES;
INFLAMMATION; SENSITIZATION
AB Background People working in cattle, swine and poultry barns have a higher prevalence of respiratory symptoms and decreased lung function. There is scant evidence regarding the respiratory health of humans working in horse barns, although it is well documented that stabled horses have a high prevalence of airway disease.
Aims To determine whether people spending time in horse barns have a higher prevalence of self-reported respiratory symptoms than non-exposed controls.
Methods A cross-sectional questionnaire study was conducted from May 2005 to January 2006 to investigate the prevalence of self-reported respiratory symptoms in 82 barn-exposed subjects and 74 control subjects. Logistic regression and the chi-square test were used to analyse the data.
Results There was a significantly higher prevalence of self-reported respiratory symptoms in the barn-exposed group (50%) versus the control group (15%). Exposure to horse barns, smoking and family history of asthma or allergies was independent risk factors for respiratory symptoms. High exposure to the horse barn yielded a higher odds ratio for self-reported respiratory symptoms (8.9).
Conclusions Exposure to the equine barn is a risk factor for respiratory symptoms. Investigation of organic dust exposures, lung function and horse dander allergies in the barn-exposed group will be necessary to determine how best to protect the health of this group.
C1 [Mazan, Melissa R.; Svatek, Jessica; Hoffman, Andrew M.] Tufts Univ, Cummings Sch Vet Med, Dept Clin Sci, North Grafton, MA 01536 USA.
[Christiani, David] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
[Ghio, Andrew] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27709 USA.
[Nadeau, Jenifer] Univ Connecticut, Storrs, CT USA.
[Maranda, Louise] Tufts Univ, Cummings Sch Vet Med, Dept Environm & Populat Hlth, North Grafton, MA 01536 USA.
RP Mazan, MR (reprint author), Tufts Univ, Cummings Sch Vet Med, Dept Clin Sci, 200 Westboro Rd, North Grafton, MA 01536 USA.
EM melissa.mazan@tufts.edu
FU National Institutes of Health [T35 DK07635]
FX National Institutes of Health (T35 DK07635).
NR 30
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U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0962-7480
J9 OCCUP MED-OXFORD
JI Occup. Med.-Oxf.
PD JUN
PY 2009
VL 59
IS 4
BP 220
EP 225
DI 10.1093/occmed/kqp003
PG 6
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 451VR
UT WOS:000266499500006
PM 19223434
ER
PT J
AU Tomimatsu, G
AF Tomimatsu, G.
TI US EPA's approach to risk assessment and regulation of biopesticides
SO PHYTOPATHOLOGY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Phytopathology-Society
CY AUG 01-05, 2009
CL Portland, OR
SP Amer Phytopathol Soc
C1 [Tomimatsu, G.] US EPA, Off Pesticide Programs, Biopesticides & Pollut Prevent Div, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER PHYTOPATHOLOGICAL SOC
PI ST PAUL
PA 3340 PILOT KNOB ROAD, ST PAUL, MN 55121 USA
SN 0031-949X
J9 PHYTOPATHOLOGY
JI Phytopathology
PD JUN
PY 2009
VL 99
IS 6
BP S175
EP S175
PG 1
WC Plant Sciences
SC Plant Sciences
GA 447SY
UT WOS:000266213301035
ER
PT J
AU Lee, CH
Teng, Q
Huang, WL
Zhong, RQ
Ye, ZH
AF Lee, Chanhui
Teng, Quincy
Huang, Wenlin
Zhong, Ruiqin
Ye, Zheng-Hua
TI Down-Regulation of PoGT47C Expression in Poplar Results in a Reduced
Glucuronoxylan Content and an Increased Wood Digestibility by Cellulase
SO PLANT AND CELL PHYSIOLOGY
LA English
DT Article
DE Biomass recalcitrance; Glucuronoxylan biosynthesis; Glycosyltransferase;
Poplar; Secondary wall biosynthesis; Wood formation
ID CELL-WALL FORMATION; LIGNIN BIOSYNTHESIS; SYNTHASE-LIKE; END-GROUPS;
XYLAN; PLANTS; GENES; ARABIDOPSIS-IRREGULAR-XYLEM8;
ARABIDOPSIS-FRAGILE-FIBER8; GLYCOSYLTRANSFERASE
AB Xylan is the second most abundant polysaccharide in dicot wood. Unraveling the biosynthetic pathway of xylan is important not only for our understanding of the process of wood formation but also for our rational engineering of wood for biofuel production. Although several glycosyltransferases are implicated in glucuronoxylan (GX) biosynthesis in Arabidopsis, whether their close orthologs in woody tree species are essential for GX biosynthesis during wood formation has not been investigated. In fact, no studies have been reported to evaluate the effects of alterations in secondary wall-associated glycosyltransferases on wood formation in tree species. In this report, we demonstrate that PoGT47C, a poplar glycosyltransferase belonging to family GT47, is essential for the normal biosynthesis of GX and the normal secondary wall thickening in the wood of the hybrid poplar Populus albatremula. RNA interference (RNAi) inhibition of PoGT47C resulted in a drastic reduction in the thickness of secondary walls, a deformation of vessels and a decreased amount of GX in poplar wood. Structural analysis of GX using nuclear magnetic resonance (NMR) spectroscopy demonstrated that the reducing end of GX from poplar wood contains the tetrasaccharide sequence, -d-Xylp-(13)-l-Rhap-(12)--d-GalpA-(14)-d-Xylp, and that its abundance was significantly decreased in the GX from the wood of the GT47C-RNAi lines. The transgenic wood was found to yield more glucose by cellulase digestion than the wild-type wood, indicating that the GX reduction in wood reduces the recalcitrance of wood to cellulase digestion. Together, these results provide direct evidence demonstrating that the PoGT47C glycosyltransferase is essential for normal GX biosynthesis in poplar wood and that GX modification could improve the digestibility of wood cellulose by cellulase.
C1 [Lee, Chanhui; Zhong, Ruiqin; Ye, Zheng-Hua] Univ Georgia, Dept Plant Biol, Athens, GA 30602 USA.
[Teng, Quincy; Huang, Wenlin] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
RP Ye, ZH (reprint author), Univ Georgia, Dept Plant Biol, Athens, GA 30602 USA.
EM zhye@plantbio.uga.edu
FU US Department of Energy [DE-FG02-03ER15415]
FX The Chemical Sciences, Geosciences and Biosciences Division, Office of
Basic Energy Sciences, Office of Science, US Department of Energy
(contract No. DE-FG02-03ER15415).
NR 33
TC 68
Z9 76
U1 1
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0032-0781
J9 PLANT CELL PHYSIOL
JI Plant Cell Physiol.
PD JUN
PY 2009
VL 50
IS 6
BP 1075
EP 1089
DI 10.1093/pcp/pcp060
PG 15
WC Plant Sciences; Cell Biology
SC Plant Sciences; Cell Biology
GA 457WZ
UT WOS:000266967600007
PM 19395414
ER
PT J
AU Drake, JW
AF Drake, John W.
TI Avoiding Dangerous Missense: Thermophiles Display Especially Low
Mutation Rates
SO PLOS GENETICS
LA English
DT Article
ID DNA-POLYMERASE; SACCHAROMYCES-CEREVISIAE; ESCHERICHIA-COLI;
SUBSTITUTION; SELECTION; FIDELITY; REPAIR; REPLICATION; SPECIFICITY
AB Rates of spontaneous mutation have been estimated under optimal growth conditions for a variety of DNA-based microbes, including viruses, bacteria, and eukaryotes. When expressed as genomic mutation rates, most of the values were in the vicinity of 0.003-0.004 with a range of less than two-fold. Because the genome sizes varied by roughly 10(4)-fold, the mutation rates per average base pair varied inversely by a similar factor. Even though the commonality of the observed genomic rates remains unexplained, it implies that mutation rates in unstressed microbes reach values that can be finely tuned by evolution. An insight originating in the 1920s and maturing in the 1960s proposed that the genomic mutation rate would reflect a balance between the deleterious effect of the average mutation and the cost of further reducing the mutation rate. If this view is correct, then increasing the deleterious impact of the average mutation should be countered by reducing the genomic mutation rate. It is a common observation that many neutral or nearly neutral mutations become strongly deleterious at higher temperatures, in which case they are called temperature-sensitive mutations. Recently, the kinds and rates of spontaneous mutations were described for two microbial thermophiles, a bacterium and an archaeon. Using an updated method to extrapolate from mutation-reporter genes to whole genomes reveals that the rate of base substitutions is substantially lower in these two thermophiles than in mesophiles. This result provides the first experimental support for the concept of an evolved balance between the total genomic impact of mutations and the cost of further reducing the basal mutation rate.
C1 Natl Inst Environm Hlth Sci, Mol Genet Lab, Res Triangle Pk, NC USA.
RP Drake, JW (reprint author), Natl Inst Environm Hlth Sci, Mol Genet Lab, Res Triangle Pk, NC USA.
EM drake@niehs.nih.gov
FU Intramural Research Program of the NIH [Z01 ES65016]; National Institute
of Environmental Health Sciences
FX This research was supported by funds allocated to project number Z01
ES65016 of the Intramural Research Program of the NIH, National
Institute of Environmental Health Sciences. The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 27
TC 45
Z9 45
U1 0
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1553-7390
J9 PLOS GENET
JI PLoS Genet.
PD JUN
PY 2009
VL 5
IS 6
AR e1000520
DI 10.1371/journal.pgen.1000520
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 476MA
UT WOS:000268444600017
PM 19543367
ER
PT J
AU Kallin, EM
Cao, R
Jothi, R
Xia, K
Cui, KR
Zhao, KJ
Zhang, Y
AF Kallin, Eric M.
Cao, Ru
Jothi, Raja
Xia, Kai
Cui, Kairong
Zhao, Keji
Zhang, Yi
TI Genome-Wide uH2A Localization Analysis Highlights Bmi1-Dependent
Deposition of the Mark at Repressed Genes
SO PLOS GENETICS
LA English
DT Article
ID EMBRYONIC STEM-CELLS; HISTONE H2A UBIQUITINATION; POLYCOMB GROUP
PROTEINS; DNA METHYLATION; DEVELOPMENTAL REGULATORS; BINDING-SITES;
COMPLEXES; H3; UBIQUITYLATION; CHROMATIN
AB Polycomb group (PcG) proteins control organism development by regulating the expression of developmental genes. Transcriptional regulation by PcG proteins is achieved, at least partly, through the PRC2-mediated methylation on lysine 27 of histone H3 (H3K27) and PRC1-mediated ubiquitylation on lysine 119 of histone H2A (uH2A). As an integral component of PRC1, Bmi1 has been demonstrated to be critical for H2A ubiquitylation. Although recent studies have revealed the genome-wide binding patterns of some of the PRC1 and PRC2 components, as well as the H3K27me3 mark, there have been no reports describing genome-wide localization of uH2A. Using the recently developed ChIP-Seq technology, here, we report genome-wide localization of the Bmi1-dependent uH2A mark in MEF cells. Gene promoter averaging analysis indicates a peak of uH2A just inside the transcription start site (TSS) of well-annotated genes. This peak is enriched at promoters containing the H3K27me3 mark and represents the least expressed genes in WT MEF cells. In addition, peak finding reveals regions of local uH2A enrichment throughout the mouse genome, including almost 700 gene promoters. Genes with promoter peaks of uH2A exhibit lower-level expression when compared to genes that do not contain promoter peaks of uH2A. Moreover, we demonstrate that genes with uH2A peaks have increased expression upon Bmi1 knockout. Importantly, local enrichment of uH2A is not limited to regions containing the H3K27me3 mark. We describe the enrichment of H2A ubiquitylation at high-density CpG promoters and provide evidence to suggest that DNA methylation may be linked to uH2A at these regions. Thus, our work not only reveals Bmi1-dependent H2A ubiquitylation, but also suggests that uH2A targeting in differentiated cells may employ a different mechanism from that in ES cells.
C1 [Kallin, Eric M.; Cao, Ru; Xia, Kai; Zhang, Yi] Univ N Carolina, Howard Hughes Med Inst, Chapel Hill, NC 27515 USA.
[Kallin, Eric M.; Cao, Ru; Xia, Kai; Zhang, Yi] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA.
[Jothi, Raja] Natl Inst Environm Hlth Sci, Biostat Branch, NIH, Res Triangle Pk, NC USA.
[Cui, Kairong; Zhao, Keji] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA.
RP Kallin, EM (reprint author), Univ N Carolina, Howard Hughes Med Inst, Chapel Hill, NC 27515 USA.
EM yi_zhang@med.unc.edu
RI Xia, Kai/B-7214-2014; Jothi, Raja/G-3780-2015
FU National Heart, Lung and Blood Institute; National Institutes of Health;
National Institute of Environmental Health Sciences, NIH [GM68804];
Howard Hughes Medical Institute
FX RJ, KC and KZ were supported by the intramural research programs of the
National Heart, Lung and Blood Institute, National Institutes of Health.
RJ was supported in part by the National Institute of Environmental
Health Sciences, NIH. Others were supported by NIH (GM68804) and the
Howard Hughes Medical Institute. YZ is an Investigator of the Howard
Hughes Medical Institute. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 53
TC 40
Z9 41
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1553-7390
J9 PLOS GENET
JI PLoS Genet.
PD JUN
PY 2009
VL 5
IS 6
AR e1000506
DI 10.1371/journal.pgen.1000506
PG 12
WC Genetics & Heredity
SC Genetics & Heredity
GA 476MA
UT WOS:000268444600039
PM 19503595
ER
PT J
AU Lau, C
AF Lau, Christopher
TI Perfluoroalkyl acids: Recent activities and research progress
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Editorial Material
ID PERFLUOROOCTANOATE PFOA CONCENTRATIONS; NHANES 1999-2000;
NATIONAL-HEALTH; US POPULATION; FLUOROCHEMICALS; TRANSPORT; BLOOD
C1 US EPA, Reprod Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Lau, C (reprint author), US EPA, Reprod Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Mail Drop 67, Res Triangle Pk, NC 27711 USA.
EM lau.christopher@epa.gov
NR 29
TC 8
Z9 8
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JUN
PY 2009
VL 27
IS 3-4
BP 209
EP 211
DI 10.1016/j.reprotox.2009.02.011
PG 3
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 445KQ
UT WOS:000266050100001
PM 19429400
ER
PT J
AU Abbott, BD
AF Abbott, Barbara D.
TI Review of the expression of peroxisome proliferator-activated receptors
alpha (PPAR alpha), beta (PPAR beta), and gamma (PPAR gamma) in rodent
and human development
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article; Proceedings Paper
CT Workshop on Perfluorooctanoic Acid Toxicokinetics and Mechanisms of
Toxicity
CY 2007
CL Res Triangle Pk, NC
SP US Environm Protect Agcy
DE Peroxisome proliferator-activated receptor; PPAR alpha; PPAR beta; PPAR
gamma; Embryo; Fetal expression
ID DIFFERENTIAL EXPRESSION; TISSUE DISTRIBUTION; PERFLUOROOCTANOIC ACID;
PERFLUOROALKYL ACIDS; NUCLEAR RECEPTORS; GENE-EXPRESSION;
ADIPOSE-TISSUE; CROSS-FOSTER; TARGET GENES; MICE LACKING
AB The peroxisome proliferator-activated receptors (PPAR)belong to the nuclear hormone receptor superfamily and there are three primary subtypes, PPAR alpha, beta, and gamma. These receptors regulate important physiological processes that impact lipid homeostasis, inflammation, adipogenesis, reproduction, wound healing, and carcinogenesis. These nuclear receptors have important roles in reproduction and development and their expression may influence the responses of an embryo exposed to PPAR agonists. PPARs are relevant to the study of the biological effects of the perfluorinated alkyl acids as these compounds, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), activate PPAR alpha. Exposure of the rodent to PFOA or PFOS during gestation results in neonatal deaths, developmental delay and growth deficits. Studies in PPAR alpha knockout mice demonstrate that the developmental effects of PFOA, but not PFOS, depend on expression of PPAR alpha. This review provides an overview of PPAR alpha, beta, and gamma protein and mRNA expression during mouse, rat, and human development. The review presents the results from many published studies and the information is organized by organ system and collated to show patterns of expression at comparable developmental stages for human, mouse, and rat. The features of the PPAR nuclear receptor family are introduced and what is known or inferred about their roles in development is discussed relative to insights from genetically modified mice and studies in the adult. Published by Elsevier Inc.
C1 [Abbott, Barbara D.] US EPA, Reprod Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Abbott, BD (reprint author), US EPA, NHEERL Bldg,2525 E Highway 54, Durham, NC 27713 USA.
EM Abbott.barbara@epa.gov
NR 67
TC 80
Z9 87
U1 8
U2 39
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JUN
PY 2009
VL 27
IS 3-4
BP 246
EP 257
DI 10.1016/j.reprotox.2008.10.001
PG 12
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 445KQ
UT WOS:000266050100005
PM 18996469
ER
PT J
AU Abbott, BD
Wolf, CJ
Das, KP
Zehr, RD
Schmid, JE
Lindstrom, AB
Strynar, MJ
Lau, C
AF Abbott, Barbara D.
Wolf, Cynthia J.
Das, Kaberi P.
Zehr, Robert D.
Schmid, Judith E.
Lindstrom, Andrew B.
Strynar, Mark J.
Lau, Christopher
TI Developmental toxicity of perfluorooctane sulfonate (PFOS) is not
dependent on expression of peroxisome proliferator activated
receptor-alpha (PPAR alpha) in the mouse
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article; Proceedings Paper
CT Workshop on Perfluorooctanoic Acid Toxicokinetics and Mechanisms of
Toxicity
CY 2007
CL Res Triangle Pk, NC
SP US Environm Protect Agcy
DE Perfluorooctane sulfonate (PFOS); Developmental toxicity; Peroxisome
proliferator activated receptor-alpha (PPAR-alpha)
ID PERFLUORINATED COMPOUNDS; SERUM CONCENTRATIONS; DIFFERENTIAL EXPRESSION;
QUANTITATIVE CHARACTERIZATION; NEONATAL-MORTALITY; NHANES 1999-2000;
NATIONAL-HEALTH; POTASSIUM-SALT; US POPULATION; BLOOD-DONORS
AB Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are members of a family of perfluorinated compounds. Both are environmentally persistent and found in the serum of wildlife and humans. PFOS and PFOA are developmentally toxic in laboratory rodents. Exposure to these chemicals in utero delays development and reduces postnatal survival and growth. Exposure to PFOS on the last 4 days of gestation in the rat is sufficient to reduce neonatal survival. PFOS and PFOA are weak agonists of peroxisome proliferator activated receptor-alpha (PPAR alpha). The reduced postnatal survival of neonatal mice exposed to PFOA was recently shown to depend on expression of PPARa. This study used PPAR alpha knockout (KO) and 129S1/SvlmJ wild type (WT) mice to determine if PPAR alpha expression is required for the developmental toxicity of PFOS. After mating overnight, the next day was designated gestation day (GD) 0. WT females were weighed and dosed orally from GD15 to 18 with 0.5% Tween-20, 4.5, 6.5. 8.5, or 10.5 mg PFOS/kg/day. KO females were dosed with 0.5% Tween-20, 8.5 or 10.5 mg PFOS/kg/day. Dams and pups were observed daily and pups were weighed on postnatal day (PND) 1 and PND15. Eye opening was recorded from PND12 to 15. Dams and pups were killed on PND15, body and liver weights recorded, and serum collected. PFOS did not affect maternal weight gain or body or liver weights of the dams on PND15. Neonatal survival (PND1-15) was significantly reduced by PFOS in both WT and KO litters at all doses. WT and KO pup birth weight and weight gain from PND1 to 15 were not significantly affected by PFOS exposure. Relative liver weight of WT and KO pups was significantly increased by the 10.5 mg/kg dose. Eye opening of PFOS-exposed pups was slightly delayed in WT and KO on PND13 or 14, respectively. Because results in WT and KO were Comparable, it is concluded that PFOS-induced neonatal lethality and delayed eye opening are not dependent on activation of PPAR alpha. Published by Elsevier Inc.
C1 [Abbott, Barbara D.; Wolf, Cynthia J.; Das, Kaberi P.; Zehr, Robert D.; Schmid, Judith E.; Lau, Christopher] US EPA, Reprod Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Lindstrom, Andrew B.; Strynar, Mark J.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Abbott, BD (reprint author), US EPA, NHEERL Bldg,2525 E Highway 54, Durham, NC 27713 USA.
EM Abbott.barbara@epa.gov
NR 57
TC 53
Z9 56
U1 1
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JUN
PY 2009
VL 27
IS 3-4
BP 258
EP 265
DI 10.1016/j.reprotox.2008.05.061
PG 8
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 445KQ
UT WOS:000266050100006
PM 18595657
ER
PT J
AU Ren, HZ
Vallanat, B
Nelson, DM
Yeung, LWY
Guruge, KS
Lam, PKS
Lehman-McKeeman, LD
Corton, JC
AF Ren, Hongzu
Vallanat, Beena
Nelson, David M.
Yeung, Leo W. Y.
Guruge, Keerthi S.
Lam, Paul K. S.
Lehman-McKeeman, Lois D.
Corton, J. Christopher
TI Evidence for the involvement of xenobiotic-responsive nuclear receptors
in transcriptional effects upon perfluoroalkyl acid exposure in diverse
species
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article; Proceedings Paper
CT Workshop on Perfluorooctanoic Acid Toxicokinetics and Mechanisms of
Toxicity
CY 2007
CL Res Triangle Pk, NC
SP US Environm Protect Agcy
DE Peroxisome proliferators; Perfluorinated alkyl acids; Perfluorooctanoic
acid; Perfluorooctane sulfonate; Liver cancer
ID CONSTITUTIVE ANDROSTANE RECEPTOR; PREGNANE-X RECEPTOR; LIVER
GENE-EXPRESSION; CARP CYPRINUS-CARPIO; PEROXISOME-PROLIFERATOR;
PERFLUOROOCTANOIC-ACID; PPAR-ALPHA; MOUSE-LIVER; RAINBOW-TROUT;
POLYFLUOROALKYL CHEMICALS
AB Humans and ecological species have been found to have detectable body burdens of a number of perfluorinated alkyl acids (PFAA) including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). In mouse and rat liver these compounds elicit transcriptional and phenotypic effects similar to peroxisome proliferator chemicals (PPC) that work through the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR alpha). Recent studies indicate that along with PPAR alpha other nuclear receptors are required for transcriptional changes in the mouse liver after PFOA exposure including the constitutive activated receptor (CAR) and pregnane X receptor (PXR) that regulate xenobiotic metabolizing enzymes (XME). To determine the potential role of CAR/PXR in mediating effects of PFAAs in rat liver, we performed a meta-analysis of transcript profiles from published studies in which rats were exposed to PFOA or PFOS. We compared the profiles to those produced by exposure to prototypical activators of CAR, (phenobarbital (PB)), PXR (pregnenolone 16 alpha-carbonitrile (PCN)), or PPAR alpha (WY-14,643 (WY)). As expected, PFOA and PFOS elicited transcript profile signatures that included many known PPAR alpha target genes. Numerous XME genes were also altered by PFOA and PFOS but not WY. These genes exhibited expression changes shared with PB or PCN. Reexamination of the transcript profiles from the livers of chicken or fish exposed to PEAAs indicated that PPAR alpha, CAR, and PXR orthologs were not activated. Our results indicate that PFAAs under these experimental conditions activate PPAR alpha, CAR, and PXR in rats but not chicken and fish. Lastly, we discuss evidence that human populations with greater CAR expression have lower body burdens of PFAAs. Published by Elsevier Inc.
C1 [Corton, J. Christopher] US EPA, Div Environm Carcinogenesis, Natl Hlth & Environm Effects Res Lab, ORD, Res Triangle Pk, NC 27711 USA.
[Ren, Hongzu; Vallanat, Beena; Corton, J. Christopher] US EPA, NHEERL Toxicogenom Core, Res Triangle Pk, NC 27711 USA.
[Nelson, David M.; Lehman-McKeeman, Lois D.] Bristol Myers Squibb Co, Discovery Toxicol, Princeton, NJ 08543 USA.
[Yeung, Leo W. Y.; Guruge, Keerthi S.] Natl Inst Anim Hlth, Safety Res Team, Tsukuba, Ibaraki 3050856, Japan.
[Yeung, Leo W. Y.; Lam, Paul K. S.] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China.
RP Corton, JC (reprint author), US EPA, Div Environm Carcinogenesis, Natl Hlth & Environm Effects Res Lab, ORD, 109 TW Alexander Dr,MD B143-06, Res Triangle Pk, NC 27711 USA.
EM corton.chris@epa.gov
RI LAM, Paul/B-9121-2008; Yeung, Leo/P-1967-2015
OI LAM, Paul/0000-0002-2134-3710; Yeung, Leo/0000-0001-6800-5658
NR 80
TC 36
Z9 38
U1 1
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JUN
PY 2009
VL 27
IS 3-4
BP 266
EP 277
DI 10.1016/j.reprotox.2008.12.011
PG 12
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 445KQ
UT WOS:000266050100007
PM 19162173
ER
PT J
AU Rosen, MB
Schmid, JE
Das, KP
Wood, CR
Zehr, RD
Lau, C
AF Rosen, Mitchell B.
Schmid, Judith E.
Das, Kaberi P.
Wood, Carmen R.
Zehr, Robert D.
Lau, Christopher
TI Gene expression profiling in the liver and lung of perfluorooctane
sulfonate-exposed mouse fetuses: Comparison to changes induced by
exposure to perfluorooctanoic acid
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article; Proceedings Paper
CT Workshop on Perfluorooctanoic Acid Toxicokinetics and Mechanisms of
Toxicity
CY 2007
CL Res Triangle Pk, NC
SP US Environm Protect Agcy
DE PFOS; PFOA; PPAR alpha; Gene profiling; Liver; Lung; Mouse; Fetus
ID ACTIVATED-RECEPTOR-ALPHA; NATIONAL BIRTH COHORT;
PEROXISOME-PROLIFERATOR; PPAR-ALPHA; NUCLEAR RECEPTORS; PERFLUOROALKYL
ACIDS; PERFLUORINATED CHEMICALS; TARGET GENES; BILE-ACIDS; CHOLESTEROL
7-ALPHA-HYDROXYLASE
AB Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are environmental contaminants found in the tissues of humans and wildlife. They are activators of peroxisome proliferator-activated receptor-alpha (PPAR alpha) and exhibit hepatocarcinogenic potential in rats. PFOS and PFOA are also developmental toxicants in rodents and PFOS has been shown to induce pulmonary deficits in rat offspring. Pregnant CD-1 mice were dosed with 0, 5, or 10 mg/kg PFOS from gestation days 1-17. Transcript profiling was conducted on the fetal liver and lung. Results were contrasted to data derived from a previous PFOA study. PFOS-dependent changes were primarily related to activation of PPAR(x. No remarkable differences were found between PFOS and PFOA. Given that PPAR alpha signaling is required for neonatal mortality in PFOA-treated mice but not those exposed to PFOS, the neonatal mortality observed for PFOS may reflect functional deficits related to the physical properties of the chemical rather than to transcript alterations. Published by Elsevier Inc.
C1 [Rosen, Mitchell B.; Schmid, Judith E.; Das, Kaberi P.; Wood, Carmen R.; Zehr, Robert D.; Lau, Christopher] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Reprod Toxicol Div, Res Triangle Pk, NC 27711 USA.
RP Rosen, MB (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Reprod Toxicol Div, MD 72, Res Triangle Pk, NC 27711 USA.
EM rosen.mitch@epa.gov
NR 88
TC 32
Z9 35
U1 2
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JUN
PY 2009
VL 27
IS 3-4
BP 278
EP 288
DI 10.1016/j.reprotox.2009.01.007
PG 11
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 445KQ
UT WOS:000266050100008
PM 19429403
ER
PT J
AU White, SS
Kato, K
Jia, LT
Basden, BJ
Calafat, AM
Hines, EP
Stanko, JP
Wolf, CJ
Abbott, BD
Fenton, SE
AF White, Sally S.
Kato, Kayoko
Jia, Lily T.
Basden, Brian J.
Calafat, Antonia M.
Hines, Erin P.
Stanko, Jason P.
Wolf, Cynthia J.
Abbott, Barbara D.
Fenton, Suzanne E.
TI Effects of perfluorooctanoic acid on mouse mammary gland development and
differentiation resulting from cross-foster and restricted gestational
exposures
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article; Proceedings Paper
CT Workshop on Perfluorooctanoic Acid Toxicokinetics and Mechanisms of
Toxicity
CY 2007
CL Res Triangle Pk, NC
SP US Environm Protect Agcy
DE Perfluorooctanoic acid (PFOA); Mammary gland; Prenatal exposure;
Neonatal exposure; Lactation; Dosimetry; Delayed development; Fetal
origins of adult disease
ID ACTIVATED RECEPTOR-ALPHA; NATIONAL BIRTH COHORT; PERFLUORINATED
CHEMICALS; SERUM CONCENTRATIONS; SULFONATE PFOS; FETAL-GROWTH;
HUMAN-MILK; BLOOD; PREGNANCY; TOXICITY
AB The adverse consequences of developmental exposures to perfluorooctanoic acid (PFOA) are established in mice, and include impaired development of the mammary gland (MG). However, the relationships between timing or route of exposure, and consequences in the MG have not been characterized. To address the effects of these variables on the onset and persistence of MG effects in female offspring, timed pregnant CD-I dams received PFOA by oral gavage over various gestational durations. Cross-fostering studies identified the 5 mg/kg dose, under either lactational- or intrauterine-only exposures, to delay MG development as early as postnatal day (PND) 1, persisting beyond PND 63. Intrauterine exposure during the final days of pregnancy caused adverse MG developmental effects similar to that of extended gestational exposures. These studies confirm a window of MG sensitivity in late fetal and early neonatal life, and demonstrate developmental PFOA exposure results in early and persistent MG effects, suggesting permanent consequences. Published by Elsevier Inc.
C1 [White, Sally S.; Hines, Erin P.; Stanko, Jason P.; Wolf, Cynthia J.; Abbott, Barbara D.; Fenton, Suzanne E.] US EPA, ORD, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[White, Sally S.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
[Kato, Kayoko; Jia, Lily T.; Basden, Brian J.; Calafat, Antonia M.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA.
RP Fenton, SE (reprint author), US EPA, ORD, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM fenton.suzanne@epa.gov
OI Hines, Erin Pias/0000-0002-2458-6267
FU Intramural NIH HHS [ZIA ES102785-01]
NR 33
TC 31
Z9 33
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JUN
PY 2009
VL 27
IS 3-4
SI SI
BP 289
EP 298
DI 10.1016/j.reprotox.2008.11.054
PG 10
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 445KQ
UT WOS:000266050100009
PM 19095057
ER
PT J
AU Reiner, JL
Nakayama, SF
Delinsky, AD
Stanko, JP
Fenton, SE
Lindstrom, AB
Strynar, MJ
AF Reiner, Jessica L.
Nakayama, Shoji F.
Delinsky, Amy D.
Stanko, Jason P.
Fenton, Suzanne E.
Lindstrom, Andrew B.
Strynar, Mark J.
TI Analysis of PFOA in dosed CD1 mice: Part 1. Methods development for the
analysis of tissues and fluids from pregnant and lactating mice and
their pups
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article; Proceedings Paper
CT Workshop on Perfluorooctanoic Acid Toxicokinetics and Mechanisms of
Toxicity
CY 2007
CL Res Triangle Pk, NC
SP US Environm Protect Agcy
DE PFOA; Reproductive; Serum; Amniotic fluid; Urine; Milk; Mammary tissue;
Whole pups
ID PERFLUOROOCTANOIC ACID; FLUOROTELOMER ALCOHOLS; SERUM CONCENTRATIONS;
HUMAN BLOOD; FLUOROCHEMICALS; EXPOSURE; MOUSE
AB The number of studies involving the analysis of perfluorooctanoic acid (PFOA) has increased recently because PFOA is routinely detected in human blood samples from around the world. Recent studies with mice have shown that dosing pregnant dams with PFOA during gestation gives rise to a dose-dependent mortality in the litters, a reduction in neonatal body weight for the surviving pups, and subsequent deficits in mammary gland development when compared to control animals. The actual body burdens of PFOA in dams and pups associated with these endpoints have not been determined, in part due to a lack of robust analytical methods for these matrices. The goal of the current study was to develop reliable methods with acceptable performance characteristics for the analysis of PFOA in several matrices relevant to pregnant mouse studies. Dam and pup serum, amniotic fluid, urine, milk, mammary tissue, and whole mouse pups were isolated for method development and analysis. The resulting method provided excellent accuracy (92.1-111%) and reproducibility (relative standard deviation 4.3-21%) making them very useful for future studies. These methods were then applied to dosed animal fluids and tissues in order to conduct a thorough evaluation of the pharmacokinetics in utero. Resulting tissue specific measurements of PFOA in serum, amniotic fluid, urine, milk, mammary tissue, and whole pup homogenate will be used to more completely describe the dose-response relationships for the most sensitive health outcomes and inform pharmacokinetic models that are being developed and evaluated. Published by Elsevier Inc.
C1 [Stanko, Jason P.; Fenton, Suzanne E.; Strynar, Mark J.] US EPA, Reprod Toxicol Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Reiner, Jessica L.; Nakayama, Shoji F.; Delinsky, Amy D.; Lindstrom, Andrew B.] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Strynar, MJ (reprint author), US EPA, Reprod Toxicol Div, Natl Hlth & Environm Effects Res Lab, Mail Drop D205-05, Res Triangle Pk, NC 27711 USA.
EM strynar.mark@epa.gov
RI Reiner, Jessica/B-9169-2008; Reiner, Jessica /B-3167-2011; Nakayama,
Shoji/B-9027-2008
FU Intramural NIH HHS [ZIA ES102785-01]
NR 18
TC 11
Z9 11
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JUN
PY 2009
VL 27
IS 3-4
BP 360
EP 364
DI 10.1016/j.reprotox.2008.10.006
PG 5
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 445KQ
UT WOS:000266050100016
PM 19028561
ER
PT J
AU Fenton, SE
Reiner, JL
Nakayama, SF
Delinsky, AD
Stanko, JP
Hines, EP
White, SS
Lindstrom, AB
Strynar, MJ
Petropoulou, SSE
AF Fenton, Suzanne E.
Reiner, Jessica L.
Nakayama, Shoji F.
Delinsky, Amy D.
Stanko, Jason P.
Hines, Erin P.
White, Sally S.
Lindstrom, Andrew B.
Strynar, Mark J.
Petropoulou, Syrago-Styliani E.
TI Analysis of PFOA in dosed CD-1 mice. Part 2: Disposition of PFOA in
tissues and fluids from pregnant and lactating mice and their pups
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article; Proceedings Paper
CT Workshop on Perfluorooctanoic Acid Toxicokinetics and Mechanisms of
Toxicity
CY 2007
CL Res Triangle Pk, NC
SP US Environm Protect Agcy
DE PFOA; serum; Amniotic fluid; Urine; Milk; Mammary gland; Dosimetry;
Disposition
ID PERFLUOROOCTANE SULFONATE PFOS; NATIONAL BIRTH COHORT; MAMMARY
BLOOD-FLOW; HUMAN BREAST-MILK; PERFLUORINATED CHEMICALS; DEVELOPMENTAL
TOXICITY; PERFLUOROALKYL ACIDS; SERUM CONCENTRATIONS; FETAL-GROWTH;
EXPOSURE
AB Previous studies in mice with multiple gestational exposures to perfluorooctanoic acid (PFOA) demonstrate numerous dose dependent growth and developmental effects which appeared to worsen if offspring exposed in utero nursed from PFOA-exposed dams. To evaluate the disposition of PFOA in the pregnant and lactating dam and her offspring, time-pregnant CD-I mice received a single 0, 0.1, 1, or 5 mg PFOA/kg BW dose (n = 25/dose group) by gavage on gestation day 17. Maternal and pup fluids and tissues were collected over time. Pups exhibited significantly higher serum PFOA concentrations than their respective dams, and their body burden increased after birth until at least postnatal day 8, regardless of dose. The distribution of milk:serum PFOA varied by dose and time, but was typically in excess of 0.20. These data suggest that milk is a substantial PFOA exposure route in mice and should be considered in risk assessment modeling designs for this compound. Published by Elsevier Inc.
C1 [Fenton, Suzanne E.; Stanko, Jason P.; Hines, Erin P.; White, Sally S.] US EPA, Reprod Toxicol Div, Natl Hlth & Environm Effects Res Lab, ORD, Res Triangle Pk, NC 27711 USA.
[Reiner, Jessica L.; Nakayama, Shoji F.; Petropoulou, Syrago-Styliani E.] US EPA, ORD, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[White, Sally S.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27599 USA.
RP Fenton, SE (reprint author), US EPA, Reprod Toxicol Div, Natl Hlth & Environm Effects Res Lab, ORD, Mail Drop 67, Res Triangle Pk, NC 27711 USA.
EM fenton.suzanne@epa.gov
RI Reiner, Jessica/B-9169-2008; Reiner, Jessica /B-3167-2011; Nakayama,
Shoji/B-9027-2008;
OI Petropoulou, Syrago-Styliani/0000-0001-8398-0136; Hines, Erin
Pias/0000-0002-2458-6267
FU Intramural NIH HHS [ZIA ES102785-01]
NR 35
TC 29
Z9 29
U1 1
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JUN
PY 2009
VL 27
IS 3-4
BP 365
EP 372
DI 10.1016/j.reprotox.2009.02.012
PG 8
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 445KQ
UT WOS:000266050100017
PM 19429407
ER
PT J
AU Rodriguez, CE
Setzer, RW
Barton, HA
AF Rodriguez, Chester E.
Setzer, R. Woodrow
Barton, Hugh A.
TI Pharmacokinetic modeling of perfluorooctanoic acid during gestation and
lactation in the mouse
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article; Proceedings Paper
CT Workshop on Perfluorooctanoic Acid Toxicokinetics and Mechanisms of
Toxicity
CY 2007
CL Res Triangle Pk, NC
SP US Environm Protect Agcy
DE Perfluorooctanoic acid; Pharmacokinetics; Modeling; Mice; Rats;
Developmental toxicity; Gestation; Lactation
ID 8-2 FLUOROTELOMER ALCOHOL; PERFLUORINATED COMPOUNDS; DEVELOPMENTAL
TOXICITY; HUMAN PLASMA; MICE; EXPOSURE; MILK; RAT; PREGNANCY; TRANSPORT
AB Perfluorooctanoic acid (PFOA) is a processing aid for the polymerization of commercially valuable fluoropolymers. Its widespread environmental distribution, presence in human blood, and adverse effects in animal toxicity studies have triggered attention to its potential adverse effects to humans. PFOA is not metabolized and exhibits dramatically different serum/plasma half-lives across species. Estimated half-lives for humans, monkeys, mice, and female rats are 3-5 years, 20-30 days, 12-20 days, and 2-4 h. respectively. Developmental toxicity is one of the most sensitive adverse effects associated with PFOA exposure in rodents, but its interpretation for risk assessment is currently hampered by the lack of understanding of the inter-species pharmacokinetics of PFOA. To address this uncertainty, a biologically supported dynamic model was developed whereby a two-compartment system linked via placental blood flow described gestation and milk production linked a lactating dam to a growing pup litter compartment. Postnatal serum levels of PFOA for 129S1/SvImJ mice at doses of 1 mg/kg or less were reasonably simulated while prenatal and postnatal measurements for CD-I mice at doses of I mg/kg or greater were simulated via the addition of a biologically based saturable renal resorption description. Our results suggest that at low doses a linear model may suffice for describing the pharmacokinetics of PFOA while a more complex model may be needed at higher doses. Although mice may appear more sensitive based on administered dose of PFOA, the internal dose metrics estimated in this analysis indicate that they may be equal or less sensitive than rats. Published by Elsevier Inc.
C1 [Rodriguez, Chester E.; Setzer, R. Woodrow; Barton, Hugh A.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Rodriguez, CE (reprint author), US EPA, Natl Ctr Computat Toxicol B205 1, Off Res & Dev, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM rodriguez.chester@epa.gov; habarton@alum.mit.edu
NR 48
TC 12
Z9 12
U1 2
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD JUN
PY 2009
VL 27
IS 3-4
BP 373
EP 386
DI 10.1016/j.reprotox.2009.02.009
PG 14
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 445KQ
UT WOS:000266050100018
PM 19429408
ER
PT J
AU Genaidy, A
Tolaymat, T
Sequeira, R
Rinder, M
Dionysiou, D
AF Genaidy, Ash
Tolaymat, Thabet
Sequeira, Reynold
Rinder, Magda
Dionysiou, Dion
TI Health effects of exposure to carbon nanofibers: Systematic review,
critical appraisal, meta analysis and research to practice perspectives
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Review
DE Carbon nanofibers; Health effects; Exposure; Workplace; Risk; Research
to practice
ID NANOTUBE CYTOTOXICITY; TOXICITY; KERATINOCYTES; NANOMATERIALS;
DEPENDENCE; TOXICOLOGY; RISKS; CELLS; RATS
AB Background: Literature reviews examining the relationship between exposure to carbon nanofibers (CNFs) and health consequences are qualitative in nature and do not employ an evidence-based assessment.
Objective: This research deals with a systematic review, critical appraisal, and meta-analysis designed to examine the potential health effects associated with exposure to CNFs. The utilization of research findings into practice is also explored.
Methods: Published articles were obtained from a search of electronic databases and bibliographies of identified articles. A critical appraisal was conducted using an 'Experimental Appraisal Instrument' developed in this study. The meta-analysis was established using statistical techniques with/without the incorporation of overall study quality. The likelihood of utilizing research findings into practice (i.e., from research to practice) was computed using a four-step algorithm based on the criteria of. strength of association, consistency among studies, temporality, biological gradient, type of experimental unit, type of CNF (single- and multi-wall nanotubes), CNF grade (commercial or altered), exposure dose, exposure duration, and support by analogy from the published literature.
Results: Twenty-one experimental studies satisfied the inclusion criteria and were performed on human cells, experimental animal models and animal cells as experimental units. The methodological qualities of published studies ranged from 'very poor' to 'excellent', with 'overall study description' scoring 'good' and 'study execution' equal to 'moderate'. The random-effects model was applied in the meta-analysis calculations as heterogeneity. was significant at the 10% for all outcomes reported. The mean standardized meta-estimates for the experimental groups were significantly lower than those for the control groups for cell viability and cell death, respectively. Incorporating the effect of overall study quality score widened the gap between the experimental and control groups. Assessment of research findings on the basis of the four-step algorithm revealed that the likelihood of the results to occur in practice is 'somewhat possible' at this time. That is, if exposure conditions to CNF in the reported studies are similar to those in nano-manufacturing plants, it is somewhat possible that CNFs alter the function of human cells resulting in loss of cell viability and cell death.
Conclusions: Our findings suggest that it is 'somewhat possible' for the CNF to penetrate the human cells in the targeted organs and to cause cellular damage. Although the weight of evidence is not sufficient, it is advisable that actions be taken to ensure the protection of workers exposed to CNFs, that is, (a) engineering controls should be established to contain exposure to CNF, and (b) simultaneously rigorous personnel protective equipment should be planned to further minimize the risk of CNF exposure. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Genaidy, Ash; Sequeira, Reynold; Dionysiou, Dion] Univ Cincinnati, Coll Engn, Cincinnati, OH 45221 USA.
[Tolaymat, Thabet] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Genaidy, Ash; Rinder, Magda] WorldTek Inc, Cincinnati, OH USA.
RP Genaidy, A (reprint author), Univ Cincinnati, Coll Engn, Cincinnati, OH 45221 USA.
EM world_tek_inc@yahoo.com
NR 38
TC 15
Z9 16
U1 1
U2 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD JUN 1
PY 2009
VL 407
IS 12
BP 3686
EP 3701
DI 10.1016/j.scitotenv.2008.12.025
PG 16
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 451BT
UT WOS:000266446400009
PM 19303626
ER
PT J
AU Grim, KC
Wolfe, M
Braunbeck, T
Iguchi, T
Ohta, Y
Tooi, O
Touart, L
Wolf, DC
Tietge, J
AF Grim, K. Christiana
Wolfe, Marilyn
Braunbeck, Thomas
Iguchi, Taisen
Ohta, Yasuhiko
Tooi, Osamu
Touart, Les
Wolf, Douglas C.
Tietge, Joe
TI Thyroid Histopathology Assessments for the Amphibian Metamorphosis Assay
to Detect Thyroid-active Substances
SO TOXICOLOGIC PATHOLOGY
LA English
DT Article
DE amphibia; metamorphosis; thyroid; histopathology; histology; Xenopus
laevis
ID ENDOCRINE DISRUPTORS; MODEL
AB In support of an Organization for Economic Cooperation and Development (OECD) Amphibian Metamorphosis Assay (AMA) Test Guideline for the detection of substances that interact with the hypothalamic-pituitary-thyroid axis, a document was developed that provides a standardized approach for evaluating the histology/histopathology of thyroid glands in metamorphosing Xenopus laevis tadpoles. Here, a consolidated description of histology evaluation practices, core diagnostic criteria and severity grading schemes for the AMA, an atlas of the normal architecture of amphibian thyroid glands over the course of metamorphosis, and the core diagnostic criteria with examples of severity grades is provided. Core diagnostic criteria include thyroid gland hypertrophy/atrophy, follicular cell hypertrophy, and follicular cell hyperplasia. The severity grading scheme is semiquantitative and employs a four-grade approach describing ranges of variation within assigned ordinal classes: not remarkable, mild, moderate, and severe. The purpose of this severity grading approach is to provide an efficient, semi-objective tool for comparing changes (compound-related effects) among animals, treatment groups, and studies. Proposed descriptions of lesions for scoring the four core criteria are also given.
C1 [Grim, K. Christiana] Ctr Species Survival, Conservat Res Ctr, Front Royal, VA 22630 USA.
[Grim, K. Christiana; Touart, Les] US EPA, Off Sci Coordinat & Policy, Washington, DC 20460 USA.
[Wolfe, Marilyn] Expt Pathol Labs Inc, Sterling, VA USA.
[Braunbeck, Thomas] Univ Heidelberg, Dept Zool, Aquat Ecol & Toxicol Grp, D-6900 Heidelberg, Germany.
[Iguchi, Taisen] Natl Inst Nat Sci, Natl Inst Basic Biol, Dept Bioenvironm Sci, Okazaki Inst Integrat Biosci,Div Bioenvironm Sci, Aichi, Japan.
[Ohta, Yasuhiko] Tottori Univ, Fac Agr, Dept Vet Med, Anim Expt Lab, Koyama, Japan.
[Tooi, Osamu] IDEA Consultants Inc, Inst Environm Ecol, Shizuoka, Japan.
[Wolf, Douglas C.; Tietge, Joe] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Wolf, Douglas C.; Tietge, Joe] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Duluth, MN USA.
RP Grim, KC (reprint author), Ctr Species Survival, Conservat Res Ctr, Smithsonian Natl Zool Pk,1500 Remount Rd, Front Royal, VA 22630 USA.
EM grim.christiana@epa.gov
OI Braunbeck, Thomas/0000-0002-1785-6759
NR 10
TC 22
Z9 23
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0192-6233
J9 TOXICOL PATHOL
JI Toxicol. Pathol.
PD JUN
PY 2009
VL 37
IS 4
BP 415
EP 424
DI 10.1177/0192623309335063
PG 10
WC Pathology; Toxicology
SC Pathology; Toxicology
GA 463YW
UT WOS:000267471200002
PM 19387088
ER
PT J
AU Wang, A
Wolf, DC
Sen, B
Knapp, GW
Holladay, SD
Huckle, WR
Caceci, T
Robertson, JL
AF Wang, Amy
Wolf, Douglas C.
Sen, Banalata
Knapp, Geremy W.
Holladay, Steven D.
Huckle, William R.
Caceci, Thomas
Robertson, John L.
TI Dimethylarsinic Acid in Drinking Water Changed the Morphology of Urinary
Bladder but Not the Expression of DNA Repair Genes of Bladder
Transitional Epithelium in F344 Rats
SO TOXICOLOGIC PATHOLOGY
LA English
DT Article
DE arsenic; dimethylarsinic acid; urothelium; DNA damage repair;
ultrastructure
ID NUCLEOTIDE EXCISION-REPAIR; IN-VITRO; HUMAN KERATINOCYTES; HUMAN
FIBROBLASTS; ARSENIC TOXICITY; UNITED-STATES; METAL MIXTURE;
NITRIC-OXIDE; B6C3F1 MICE; HUMAN-CELLS
AB Inorganic arsenic increases urinary bladder transitional cell carcinoma in humans. In F344 rats, dimethylarsinic acid (DMA[ V]) increases transitional cell carcinoma. Arsenic-induced inhibition of DNA repair has been reported in cultured cell lines and in lymphocytes of arsenic-exposed humans, but it has not been studied in urinary bladder. Should inhibition of DNA damage repair in transitional epithelium occur, it may contribute to carcinogenesis or cocarcinogenesis. We investigated morphology and expression of DNA repair genes in F344 rat transitional cells following up to 100 ppm DMA(V) in drinking water for four weeks. Mitochondria were very sensitive to DMA(V), and swollen mitochondria appeared to be the main source of vacuoles in the transitional epithelium. Real-time reverse transcriptase polymerase chain reaction (Real-Time RT PCR) showed the mRNA levels of tested DNA repair genes, ataxia telangectasia mutant (ATM), X-ray repair cross-complementing group 1 (XRCC1), excision repair cross-complementing group 3/xeroderma pigmentosum B (ERCC3/XPB), and DNA polymerase beta (Pol beta), were not altered by DMA(V). These data suggested that either DMA(V) does not affect DNA repair in the bladder or DMA(V) affects DNA repair without affecting baseline mRNA levels of repair genes. The possibility remains that DMA(V) may lower damage-induced increases in repair gene expression or cause post-translational modification of repair enzymes.
C1 [Sen, Banalata] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
[Wolf, Douglas C.; Knapp, Geremy W.] US EPA, Div Environm Carcinogenesis, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Wang, Amy; Holladay, Steven D.; Huckle, William R.; Caceci, Thomas; Robertson, John L.] Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24061 USA.
RP Wang, A (reprint author), US EPA, Natl Ctr Environm Assessment B 243 01, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM amywang@vt.edu
NR 55
TC 10
Z9 10
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0192-6233
J9 TOXICOL PATHOL
JI Toxicol. Pathol.
PD JUN
PY 2009
VL 37
IS 4
BP 425
EP 437
DI 10.1177/0192623309334147
PG 13
WC Pathology; Toxicology
SC Pathology; Toxicology
GA 463YW
UT WOS:000267471200003
PM 19387086
ER
PT J
AU Elespuru, RK
Agarwal, R
Atrakchi, AH
Bigger, CAH
Heflich, RH
Jagannath, DR
Levy, DD
Moore, MM
Ouyang, YL
Robison, TW
Sotomayor, RE
Cimino, MC
Dearfield, KL
AF Elespuru, Rosalie K.
Agarwal, Rajiv
Atrakchi, Aisar H.
Bigger, C. Anita H.
Heflich, Robert H.
Jagannath, Devaraya R.
Levy, Dan D.
Moore, Martha M.
Ouyang, Yanli
Robison, Timothy W.
Sotomayor, Rene E.
Cimino, Michael C.
Dearfield, Kerry L.
TI Current and Future Application of Genetic Toxicity Assays: The Role and
Value of In Vitro Mammalian Assays
SO TOXICOLOGICAL SCIENCES
LA English
DT Editorial Material
ID HUMAN SAFETY EVALUATION; PREDICTING RODENT CARCINOGENICITY; MOUSE
LYMPHOMA-CELLS; MUTATION ASSAY; INTERNATIONAL WORKSHOP; RISK-ASSESSMENT;
FOLLOW-UP; GENOTOXICITY TESTS; MUTAGENIC POTENCY; PIG-A
AB With the advent of new technologies (e.g., genomics, automated analyses, and in vivo monitoring), new regulations (e.g., the reduction of animal tests by the European REACH), and new approaches to toxicology (e.g., Toxicity Testing in the 21st Century, National Research Council), the field of regulatory genetic toxicology is undergoing a serious re-examination. Within this context, Toxicological Sciences has published a series of articles in its Forum Section on the theme, "Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation" (beginning with Goodman et al.). As a contribution to the Forum discussions, we present current methods for evaluating mutagenic/genotoxic risk using standard genotoxicity test batteries, and suggest ways to address and incorporate new technologies. We recognize that the occurrence of positive results in relation to cancer prediction has led to criticism of in vitro mammalian cell genetic toxicity assays. We address criticism of test results related to weak positives, associated only with considerable toxicity, only seen at high concentrations, not accompanied by positive results in the other tests of standard test batteries, and/or not correlating well with rodent carcinogenicity tests. We suggest that the problems pointed out by others with these assays already have been resolved, to a large extent, by international groups working to update assay protocols, and by changes in data interpretation at regulatory agencies. New guidances at the U.S. Environmental Protection Agency and the U.S. Food and Drug Administration improve data evaluation and help refocus risk assessment. We discuss the results of international groups working together to integrate new technologies and evaluate new tests, including human monitoring. We suggest that strategies for identifying human health risks should naturally change to integrate new technologies; however, changes should be made only when justified by strong scientific evidence of improvement in the risk assessment paradigm.
C1 [Elespuru, Rosalie K.] US FDA, CDRH, OSEL, DB, Silver Spring, MD 20993 USA.
[Elespuru, Rosalie K.; Atrakchi, Aisar H.; Bigger, C. Anita H.; Heflich, Robert H.; Jagannath, Devaraya R.; Levy, Dan D.; Moore, Martha M.; Robison, Timothy W.; Sotomayor, Rene E.] US FDA, GeneTox Network, Silver Spring, MD 20993 USA.
[Elespuru, Rosalie K.; Agarwal, Rajiv; Atrakchi, Aisar H.; Bigger, C. Anita H.; Heflich, Robert H.; Jagannath, Devaraya R.; Levy, Dan D.; Moore, Martha M.; Ouyang, Yanli; Robison, Timothy W.; Sotomayor, Rene E.] CDER, Genet Toxicol Subcomm, Silver Spring, MD 20993 USA.
[Agarwal, Rajiv] US FDA, Off Pharmaceut Sci, Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA.
[Atrakchi, Aisar H.; Bigger, C. Anita H.; Ouyang, Yanli; Robison, Timothy W.] US FDA, Off New Drugs, Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA.
[Heflich, Robert H.; Moore, Martha M.] US FDA, Div Genet & Reprod Toxicol, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA.
[Jagannath, Devaraya R.] US FDA, Off New Anim Drug Evaluat, Ctr Vet Med, Rockville, MD 20855 USA.
[Levy, Dan D.; Sotomayor, Rene E.] US FDA, Off Nutr Labeling & Dietary Supplements, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA.
[Cimino, Michael C.] US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA.
[Dearfield, Kerry L.] US Food Safety & Inspect Serv, Off Publ Hlth Sci, USDA, Washington, DC 20250 USA.
RP Elespuru, RK (reprint author), US FDA, CDRH, OSEL, DB, Bldg 64-3020,10903 New Hampshire Ave, Silver Spring, MD 20993 USA.
EM rosalie.elespuru@fda.hhs.gov
NR 53
TC 29
Z9 30
U1 2
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUN
PY 2009
VL 109
IS 2
BP 172
EP 179
DI 10.1093/toxsci/kfp067
PG 8
WC Toxicology
SC Toxicology
GA 449VH
UT WOS:000266357900002
PM 19336498
ER
PT J
AU Watanabe, KH
Li, Z
Kroll, KJ
Villeneuve, DL
Garcia-Reyero, N
Orlando, EF
Sepulveda, MS
Collette, TW
Ekman, DR
Ankley, GT
Denslow, ND
AF Watanabe, Karen H.
Li, Zhenhong
Kroll, Kevin J.
Villeneuve, Daniel L.
Garcia-Reyero, Natalia
Orlando, Edward F.
Sepulveda, Maria S.
Collette, Timothy W.
Ekman, Drew R.
Ankley, Gerald T.
Denslow, Nancy D.
TI A Computational Model of the Hypothalamic-Pituitary-Gonadal Axis in Male
Fathead Minnows Exposed to 17 alpha-Ethinylestradiol and 17
beta-Estradiol
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE EE(2); E(2); fish; steroid hormones; environmental estrogen; Markov
chain Monte Carlo simulation; predictive toxicology; system model
ID ENDOCRINE-ACTIVE COMPOUNDS; ZEBRAFISH DANIO-RERIO; WASTE-WATER EFFLUENT;
STEROID-BINDING-PROTEIN; MEDAKA ORYZIAS-LATIPES; PIMEPHALES-PROMELAS;
ESTROGEN-RECEPTOR; RAINBOW-TROUT; LIFE-CYCLE; MOLECULAR CHARACTERIZATION
AB Estrogenic chemicals in the aquatic environment have been shown to cause a variety of reproductive anomalies in fish including full sex reversal, intersex, and altered population sex ratios. Two estrogens found in the aquatic environment, 17 alpha-ethinylestradiol (EE(2)) and 17 beta-estradiol (E(2)), have been measured in wastewater treatment effluents and have been shown to cause adverse effects in fish. To further our understanding of how estrogen exposure affects reproductive endpoints in the male fathead minnow (FHM, Pimephales promelas), a physiologically based computational model was developed of the hypothalamic-pituitary-gonadal (HPG) axis. Apical reproductive endpoints in the model include plasma steroid hormone and vitellogenin concentrations. Using Markov chain Monte Carlo simulation, the model was calibrated with data from unexposed FHM, and FHM exposed to EE(2) and E(2). Independent experimental data sets were used to evaluate model predictions. We found good agreement between our model predictions and a variety of measured reproductive endpoints, although the model underpredicts unexposed FHM reproductive endpoint variances, and overpredicts variances in estrogen-exposed FHM. We conclude that this model provides a robust representation of the HPG axis in male FHM.
C1 [Watanabe, Karen H.; Li, Zhenhong] Oregon Hlth & Sci Univ, Div Environm & Biomol Syst, Dept Sci & Engn, Beaverton, OR 97006 USA.
[Kroll, Kevin J.; Garcia-Reyero, Natalia; Denslow, Nancy D.] Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA.
[Kroll, Kevin J.; Garcia-Reyero, Natalia; Denslow, Nancy D.] Univ Florida, Ctr Environm & Human Toxicol, Gainesville, FL 32611 USA.
[Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[Orlando, Edward F.] Univ Maryland, Anim & Avian Sci Dept, College Pk, MD 20742 USA.
[Sepulveda, Maria S.] Purdue Univ, Dept Forestry & Nat Resources, W Lafayette, IN 47907 USA.
[Collette, Timothy W.; Ekman, Drew R.] US EPA, Ecosyst Res Div, Athens, GA 30605 USA.
RP Watanabe, KH (reprint author), Oregon Hlth & Sci Univ, Div Environm & Biomol Syst, Dept Sci & Engn, West Campus,20000 NW Walker Rd, Beaverton, OR 97006 USA.
EM watanabe@ebs.ogi.edu
RI li, zhenhong/B-1699-2014; Sepulveda, Maria/P-3598-2014
FU Medical Research Foundation of Oregon [0634]; Environmental Protection
Agency (EPA) Science to Achieve Results program [RD-83184801-0];
National Center for Computational Toxicology of the EPA Office of
Research and Development
FX Medical Research Foundation of Oregon (Grant no. 0634) to K. W.; U. S.
Environmental Protection Agency (EPA) Science to Achieve Results program
(Cooperative Agreement no. RD-83184801-0) to N. D., K. W., M. S., and E.
O.; and National Center for Computational Toxicology of the EPA Office
of Research and Development, awarded to the Ecological Exposure Research
and Ecosystem Research Divisions (National Exposure Research Laboratory)
in Cincinnati, OH and Athens, GA, respectively, and the Mid-Continent
Ecology Division (National Health and Environmental Effects Research
Laboratory) in Duluth, MN.
NR 82
TC 25
Z9 26
U1 0
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUN
PY 2009
VL 109
IS 2
BP 180
EP 192
DI 10.1093/toxsci/kfp069
PG 13
WC Toxicology
SC Toxicology
GA 449VH
UT WOS:000266357900003
PM 19357070
ER
PT J
AU Benignus, VA
Bushnell, PJ
Boyes, WK
Eklund, C
Kenyon, EM
AF Benignus, Vernon A.
Bushnell, Philip J.
Boyes, William K.
Eklund, Chris
Kenyon, Elaina M.
TI Neurobehavioral Effects of Acute Exposure to Four Solvents:
Meta-analyses
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE toxicity; acute nervous system; volatile organic compounds
ID TOLUENE EXPOSURE; DOSIMETRIC ANALYSIS; INHALED TOLUENE; RATS;
1,1,1-TRICHLOROETHANE; TRICHLOROETHYLENE; PERFORMANCE; INHALATION;
HUMANS; BLOOD
AB Meta- and reanalyses of the available data for the neurobehavioral effects of acute inhalation exposure to toluene were reported by Benignus et al. The present study was designed to test the generality of the toluene results in as many other solvents as possible by further meta- and reanalyses. Sufficient data for meta-analyses were found for only four solvents; toluene, trichloroethylene, perchloroethylene, and 1,1,1-trichloroethane. The results for these solvents showed that rats were less affected by each of the solvents when they were tested in highly motivating situations, for example, rewarded for rapid or correct responding or escape from electrical shock, compared with less motivating circumstances. The four solvents did not differ significantly in potency on any outcome measure when dose was expressed as molar brain concentration. When tested in tasks with low-motivational contingencies, the dose-effect curves of humans (reaction times) and rats (electrophysiological responses to visual stimuli) were not significantly different. However, on an exploratory follow-up analysis, humans were less sensitive than rats. No human data were found to test whether species differed under strong motivation. Dose-equivalence curves were derived for extrapolating to human effects from rat data.
C1 [Benignus, Vernon A.] US EPA, Human Studies Div, Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Benignus, Vernon A.] Univ N Carolina, Dept Psychol, Chapel Hill, NC USA.
[Bushnell, Philip J.; Boyes, William K.] US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Eklund, Chris; Kenyon, Elaina M.] US EPA, Expt Toxicol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Benignus, VA (reprint author), US EPA, Human Studies Div, Hlth & Environm Effects Res Lab, Off Res & Dev, Mail Code B105-06, Res Triangle Pk, NC 27711 USA.
EM benignus.vernon@epa.gov
FU National Health and Environmental Effects Research Laboratory; U.S.
Environmental Protection Agency
FX This manuscript has been reviewed by the National Health and
Environmental Effects Research Laboratory, U.S. Environmental Protection
Agency, and approved for publication. Approval does not signify that the
contents necessarily reflect the policies of the agency nor does mention
of trade names or commercial products constitute endorsement or
recommendation for use.
NR 41
TC 17
Z9 17
U1 1
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUN
PY 2009
VL 109
IS 2
BP 296
EP 305
DI 10.1093/toxsci/kfp063
PG 10
WC Toxicology
SC Toxicology
GA 449VH
UT WOS:000266357900014
PM 19339666
ER
PT J
AU Williams-Devane, CR
Wolf, MA
Richard, AM
AF Williams-Devane, ClarLynda R.
Wolf, Maritja A.
Richard, Ann M.
TI Toward a Public Toxicogenomics Capability for Supporting Predictive
Toxicology: Survey of Current Resources and Chemical Indexing of
Experiments in GEO and ArrayExpress
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE microarray; chemical; toxicogenomics; toxicity; prediction
ID GENE-EXPRESSION OMNIBUS; BIOLOGICAL-SYSTEMS; MICROARRAY DATA; TOXICITY
DATA; DATA-STORAGE; DATABASE; STANDARDS; INTEGRATION; CEBS; TOOL
AB A publicly available toxicogenomics capability for supporting predictive toxicology and meta-analysis depends on availability of gene expression data for chemical treatment scenarios, the ability to locate and aggregate such information by chemical, and broad data coverage within chemical, genomics, and toxicological information domains. This capability also depends on common genomics standards, protocol description, and functional linkages of diverse public Internet data resources. We present a survey of public genomics resources from these vantage points and conclude that, despite progress in many areas, the current state of the majority of public microarray databases is inadequate for supporting these objectives, particularly with regard to chemical indexing. To begin to address these inadequacies, we focus chemical annotation efforts on experimental content contained in the two primary public genomic resources: ArrayExpress and Gene Expression Omnibus. Automated scripts and extensive manual review were employed to transform free-text experiment descriptions into a standardized, chemically indexed inventory of experiments in both resources. These files, which include top-level summary annotations, allow for identification of current chemical-associated experimental content, as well as chemical-exposure-related (or "Treatment") content of greatest potential value to toxicogenomics investigation. With these chemical-index files, it is possible for the first time to assess the breadth and overlap of chemical study space represented in these databases, and to begin to assess the sufficiency of data with shared protocols for chemical similarity inferences. Chemical indexing of public genomics databases is a first important step toward integrating chemical, toxicological and genomics data into predictive toxicology.
C1 [Williams-Devane, ClarLynda R.] US EPA, Off Res & Dev, NHEERL, Res Triangle Pk, NC 27519 USA.
[Wolf, Maritja A.] Lockheed Martin, Res Triangle Pk, NC 27519 USA.
[Richard, Ann M.] US EPA, Off Res & Dev, NCCT, Res Triangle Pk, NC 27519 USA.
RP Richard, AM (reprint author), US EPA, Mail Drop D343-03,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM richard.ann@epa.gov
FU NCSU/EPA [CT833235-01-0]; North Carolina State University
FX NCSU/EPA Cooperative Training Program in Environmental Sciences
Research, Training Agreement (CT833235-01-0) with North Carolina State
University supported C. R. W.
NR 38
TC 15
Z9 17
U1 2
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUN
PY 2009
VL 109
IS 2
BP 358
EP 371
DI 10.1093/toxsci/kfp061
PG 14
WC Toxicology
SC Toxicology
GA 449VH
UT WOS:000266357900020
PM 19332651
ER
PT J
AU Wood, JP
Martin, GB
AF Wood, Joseph P.
Martin, G. Blair
TI Development and field testing of a mobile chlorine dioxide generation
system for the decontamination of buildings contaminated with Bacillus
anthracis
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Chlorine dioxide; Decontamination; Bacillus anthracis; Biological agent
AB The numerous buildings that became contaminated with Bacillus anthracis (the bacterium causing the disease anthrax) in 2001, and more recent B. anthracis - related events, point to the need to have effective decontamination technologies for buildings contaminated with biological threat agents. The U.S. Government developed a portable chlorine dioxide (ClO(2)) generation system to decontaminate buildings contaminated with B. anthracis spores, and this so-called mobile decontamination trailer (MDT) prototype was tested through a series of three field trials. The first test of the MDT was conducted at Fort McClellan in lAnniston, AL. during October 2004. Four test attempts occurred over two weekends; however, a number of system problems resulted in termination of the activity prior to any ClO(2) introduction into the test building. After making several design enhancements and equipment changes. the MDT was subjected to a second test. During this test, extensive leak checks were made using argon and nitrogen in lieu of chlorine gas; each subsystem was checked for functionality, and the MDT was operated for 24 h. This second test demonstrated the MDT flow and control systems functioned satisfactorily, and thus it was decided to proceed to a third, more challenging field trial. In the last field test, ClO(2) was generated and routed directly to the scrubber in a 12-h continuous run. Measurement Of ClO(2) levels at the generator outlet showed that the desired production rate was not achieved. Additionally, only one of the two scrubbers performed adequately with regard to maintaining ClO(2) emissions below the limit. Numerous lessons were learned in the field trials of this ClO(2) decontamination technology. Published by Elsevier B.V.
C1 [Wood, Joseph P.] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA.
[Martin, G. Blair] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
RP Wood, JP (reprint author), US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, MC-E343-06, Res Triangle Pk, NC 27711 USA.
EM wood.joe@epa.gov; martin.blair@epa.gov
OI Wood, Joseph/0000-0001-6316-9418
FU Murtech; Naval Surface Warfare Center; HSARPA; JPEO; DARPA; Science
Applications International Corporation; Battelle; EPA
FX The authors would like to acknowledge the support and efforts of the
following people and their organizations: Bob Murtha (Murtech), John
Thompson (Naval Surface Warfare Center), Michael Mcloughlin (HSARPA),
Michael Walter (JPEO), Wayne Bryden (DARPA), Sabine Kunig (Science
Applications International Corporation), Richard Rossman (Battelle), and
Dave Mickunas (EPA).
NR 12
TC 10
Z9 11
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD MAY 30
PY 2009
VL 164
IS 2-3
BP 1460
EP 1467
DI 10.1016/j.jhazmat.2008.09.062
PG 8
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 435QM
UT WOS:000265358400149
PM 18990488
ER
PT J
AU Vonderheide, AP
Boyd, B
Ryberg, A
Yilmaz, E
Hieber, TE
Kauffman, PE
Garris, ST
Morgan, JN
AF Vonderheide, Anne P.
Boyd, Brian
Ryberg, Anna
Yilmaz, Ecevit
Hieber, Thomas E.
Kauffman, Peter E.
Garris, Sherry T.
Morgan, Jeffrey N.
TI Analysis of permethrin isomers in composite diet samples by molecularly
imprinted solid-phase extraction and isotope dilution gas
chromatography-ion trap mass spectrometry
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Pyrethroid pesticides; Composite diet; Isotope dilution; Solid-phase
extraction; Molecularly imprinted polymer
ID PYRETHROID PESTICIDES; SELECTIVE EXTRACTION; BIOLOGICAL SAMPLES;
ELECTRON-CAPTURE; BASIC DRUG; POLYMERS; CLEANUP; RESIDUES; WATER;
VEGETABLES
AB Determination of an individual's aggregate dietary ingestion of pesticides entails analysis of a difficult sample matrix. Permethrin-specific molecularly imprinted polymer (MIP) solid-phase extraction cartridges were developed for use as a sample preparation technique for a composite food matrix, Vortexing with acetonitrile and centrifugation were found to provide optimal extraction of the permethrin isomers from the composite foods. The acetonitrile (with 1% acetic acid) was mostly evaporated and the analytes reconstituted in 90:10 water/acetonitrile in preparation for molecularly imprinted solid-phase extraction. Permethrin elution was accomplished with acetonitrile and sample extracts were analyzed by isotope dilution gas chromatography-ion trap mass spectrometry. Quantitation of product ions provided definitive identification of the pesticide isomers. The final method parameters were tested with fortified composite food samples of varying fat content (1%, 5%, and 10%) and recoveries ranged from 99.3% to 126%. Vegetable samples with incurred pesticide levels were also analyzed with the given method and recoveries were acceptable (81.0-95.7%). Method detection limits were demonstrated in the low ppb range. Finally, the applicability of the MIP stationary phase to extract other pyrethroids, specifically cyfluthrin and cypermethrin, was also investigated. Published by Elsevier B.V.
C1 [Vonderheide, Anne P.; Morgan, Jeffrey N.] US EPA, Natl Exposure Res Lab, Microbiol & Chem Exposure Assessment Res Div, Chem Exposure Res Branch, Cincinnati, OH 45268 USA.
[Boyd, Brian; Ryberg, Anna; Yilmaz, Ecevit] MIP Technol AB, S-22007 Lund, Sweden.
[Hieber, Thomas E.; Kauffman, Peter E.] US EPA, Natl Council Aging, Natl Exposure Res Lab,Chem Exposure Res Branch, Microbiol & Chem Exposure Assessment Res Div, Cincinnati, OH 45268 USA.
[Garris, Sherry T.] S Carolina Dept Agr, Columbia, SC 29201 USA.
RP Morgan, JN (reprint author), US EPA, Natl Exposure Res Lab, Microbiol & Chem Exposure Assessment Res Div, Chem Exposure Res Branch, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM morgan.jeffrey@epa.gov
NR 41
TC 16
Z9 17
U1 0
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0021-9673
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD MAY 29
PY 2009
VL 1216
IS 22
BP 4633
EP 4640
DI 10.1016/j.chroma.2009.03.077
PG 8
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 449CH
UT WOS:000266307900001
PM 19393156
ER
PT J
AU Hines, EP
White, SS
Stanko, JP
Gibbs-Flournoy, EA
Lau, C
Fenton, SE
AF Hines, Erin P.
White, Sally S.
Stanko, Jason P.
Gibbs-Flournoy, Eugene A.
Lau, Christopher
Fenton, Suzanne E.
TI Phenotypic dichotomy following developmental exposure to
perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce
elevated serum leptin and insulin, and overweight in mid-life
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article; Proceedings Paper
CT 16th European Congress on Obesity
CY 2008
CL Geneva, SWITZERLAND
DE PFOA; Overweight; Leptin; Developmental exposure; Obesity; Ovariectomy
ID ACTIVATED RECEPTOR-ALPHA; PEROXISOME-PROLIFERATOR; ADIPOSE-TISSUE;
PERFLUORINATED COMPOUNDS; SULFONATE PFOS; RATS; MOUSE; EXPRESSION;
OBESITY; FAT
AB The synthetic surfactant, perfluorooctanoic acid (PFOA) is a proven developmental toxicant in mice, causing pregnancy loss, increased neonatal mortality, delayed eye opening, and abnormal mammary gland growth in animals exposed during fetal life. PFOA is found in the sera and tissues of wildlife and humans throughout the world, but is especially high in the sera of children compared to adults. These studies in CD-1 mice aim to determine the latent health effects of PFOA following: (1) an in utero exposure, (2) an in utero, exposure followed by ovariectomy (ovx), or (3) exposure as an adult. Mice were exposed to 0, 0.01, 0.1, 0.3,71, 3, or 5 mg PFOA/kg BW for 17 days of pregnancy or as young adults. Body weight was reduced in the highest doses on postnatal day (PND) 1 and at weaning. However, the lowest exposures (0.01-0.3 mg/kg) significantly increased body weight, and serum insulin and leptin (0.01-0.1 mg/kg) in mid-life after developmental exposure. PFOA exposure combined with ovx caused no additional increase in mid-life body weight. At 18 months of age, the effects of in utero PFOA exposure on body weight were no longer detected. White adipose tissue and spleen weights were decreased at high doses of PFOA in intact developmentally exposed mice, and spleen weight was reduced in PFOA-exposed ovx mice. Brown adipose tissue weight was significantly increased in both ovx and intact mice at high PFOA doses. Liver weight was unaffected in late life by these exposure paradigms. Finally, there was no effect of adult exposure to PFOA on body weight. These studies demonstrate an important window of exposure for low-dose effects of PFOA on body weight gain. as well as leptin and insulin concentrations in mid-life, at a lowest observed effect level of 0.01 mg PFOA/kg BW. The mode of action of these effects and its relevance to human health remain to be explored. Published by Elsevier Ireland Ltd.
C1 [Hines, Erin P.] US EPA, Natl Ctr Exposure Anal, Environm Media Assessment Grp, Reprod Toxicol Div,Off Res & Dev,Natl Hlth & Envi, Res Triangle Pk, NC 27711 USA.
[White, Sally S.] UNC Chapel Hill, Curriculum Toxicol, Chapel Hill, NC 27599 USA.
[Gibbs-Flournoy, Eugene A.] UNC Chapel Hill, Biol & Biomed Sci Program, Initiat Maximizing Student Divers, Chapel Hill, NC 27599 USA.
RP Hines, EP (reprint author), US EPA, Natl Ctr Exposure Anal, Environm Media Assessment Grp, Reprod Toxicol Div,Off Res & Dev,Natl Hlth & Envi, Res Triangle Pk, NC 27711 USA.
EM hines.erin@epa.gov
OI Hines, Erin Pias/0000-0002-2458-6267
NR 45
TC 74
Z9 77
U1 1
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD MAY 25
PY 2009
VL 304
IS 1-2
BP 97
EP 105
DI 10.1016/j.mce.2009.02.021
PG 9
WC Cell Biology; Endocrinology & Metabolism
SC Cell Biology; Endocrinology & Metabolism
GA 455HR
UT WOS:000266749800014
PM 19433254
ER
PT J
AU Pierce, RB
Al-Saadi, J
Kittaka, C
Schaack, T
Lenzen, A
Bowman, K
Szykman, J
Soja, A
Ryerson, T
Thompson, AM
Bhartia, P
Morris, GA
AF Pierce, R. Bradley
Al-Saadi, Jassim
Kittaka, Chieko
Schaack, Todd
Lenzen, Allen
Bowman, Kevin
Szykman, Jim
Soja, Amber
Ryerson, Tom
Thompson, Anne M.
Bhartia, Pawan
Morris, Gary A.
TI Impacts of background ozone production on Houston and Dallas, Texas, air
quality during the Second Texas Air Quality Study field mission
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
ID TROPOSPHERIC OZONE; MONITORING INSTRUMENT; AURA MISSION; OBJECTIVES;
RETRIEVAL; MECHANISM; EMISSIONS; SYSTEM; ASIA; TES
AB A major objective of the 2006 Second Texas Air Quality Study (TexAQS II) focused on understanding the effects of regional processes on Houston and Dallas ozone nonattainment areas. Here we quantify the contributions of background (continental scale) ozone production on Houston and Dallas air quality during TexAQS II using ensemble Lagrangian trajectories to identify remote source regions that impact Houston and Dallas background ozone distributions. Global-scale chemical analyses, constrained with composition measurements from instruments on the NASA Aura satellite, are used to provide estimates of background composition along ensemble back trajectories. Lagrangian averaged O-3 net photochemical production (production minus loss, P-L) rates along the back trajectories are used as a metric to classify back trajectories. Results show that the majority (6 out of 9 or 66%) of the periods of high ozone in Houston were associated with periods of enhanced background ozone production. Slightly less than 50% (7 out of 15) of the days with high ozone in the Dallas Metropolitan Statistical Area (MSA) show enhanced background ozone production. Source apportionment studies show that 5-day Lagrangian averaged O-3 P-L in excess of 15 ppbv/d can occur during continental-scale transport to Houston owing to NOy enhancements from emissions within the Southern Great Lakes as well as recirculation of the Houston emissions. Dallas background O-3 P-L is associated with NOy enhancements from emissions within Chicago and Houston.
C1 [Pierce, R. Bradley] NOAA, NESDIS, Adv Satellite Prod Branch, Ctr Satellite Applicat & Res,Cooperat Res Program, Madison, WI 53706 USA.
[Al-Saadi, Jassim] NASA, Langley Res Ctr, Chem & Dynam Branch, Sci Directorate, Hampton, VA 23681 USA.
[Bhartia, Pawan] NASA, Goddard Space Flight Ctr, Atmospheres Lab, Code 613, Greenbelt, MD 20771 USA.
[Bowman, Kevin] CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA.
[Kittaka, Chieko] Sci Syst & Applicat Inc, Hampton, VA 23666 USA.
[Schaack, Todd; Lenzen, Allen] Univ Wisconsin, Ctr Space Sci & Engn, Madison, WI 53706 USA.
[Morris, Gary A.] Valparaiso Univ, Dept Phys & Astron, Valparaiso, IN 46383 USA.
[Ryerson, Tom] NOAA, Earth Syst Res Lab, Div Chem Sci, Boulder, CO 80305 USA.
[Soja, Amber] Natl Inst Aerosp, Hampton, VA 23666 USA.
[Thompson, Anne M.] Penn State Univ, Dept Meteorol, University Pk, PA 16802 USA.
[Szykman, Jim] NASA, Langley Res Ctr, Natl Exposure Res Lab, Off Res & Dev,US EPA, Hampton, VA 23665 USA.
RP Pierce, RB (reprint author), NOAA, NESDIS, Adv Satellite Prod Branch, Ctr Satellite Applicat & Res,Cooperat Res Program, 1225 W Dayton St, Madison, WI 53706 USA.
EM brad.pierce@noaa.gov
RI Pierce, Robert Bradley/F-5609-2010; Ryerson, Tom/C-9611-2009; Thompson,
Anne /C-3649-2014
OI Pierce, Robert Bradley/0000-0002-2767-1643; Thompson, Anne
/0000-0002-7829-0920
FU U.S. Department of Energy [DE-AC02-05CH11231]
FX Thanks go to Bruce Doddridge of the National Aeronautics and Space
Administration, Tropospheric Chemistry Program, and Fred Fehsenfeld of
the National Oceanic and Atmospheric Administration Earth Systems
Research Laboratory for coordinating the NASA involvement in the TexAQS
II field mission. Thanks go to an anonymous reviewer for suggesting the
sensitivity studies used to examine the role of intraregional transport
during the Houston and Dallas high-ozone days. Support for IONS-06 and
RAQMS came from the NASA Tropospheric Chemistry Program. The views,
opinions, and findings contained in this report are those of the
author(s) and should not be construed as an official National Oceanic
and Atmospheric Administration or U. S. Government position, policy, or
decision. This research used resources of the National Energy Research
Scientific Computing Center, which is supported by the Office of Science
of the U.S. Department of Energy under contract DE-AC02-05CH11231.
NR 39
TC 21
Z9 21
U1 4
U2 12
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD MAY 23
PY 2009
VL 114
AR D00F09
DI 10.1029/2008JD011337
PG 14
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 449XL
UT WOS:000266364000004
ER
PT J
AU Yang, Q
Choi, H
Al-Abed, SR
Dionysiou, DD
AF Yang, Qiujing
Choi, Hyeok
Al-Abed, Souhail R.
Dionysiou, Dionysios D.
TI Iron-cobalt mixed oxide nanocatalysts: Heterogeneous peroxymonosulfate
activation, cobalt leaching, and ferromagnetic properties for
environmental applications
SO APPLIED CATALYSIS B-ENVIRONMENTAL
LA English
DT Article
DE 2,4-Dichlorophenol; Advanced oxidation processes (AOPs); Advanced
oxidation technologies (AOTs); Cobalt; Fe-Co; Ferromagnetic properties;
Heterogeneous reaction; Iron; Iron-cobalt; Leaching; Mixed oxide;
Nanoparticles; Oxone; Peroxymonosulfate; Support materials; Sulfate
radicals; Titanium dioxide; Titania; TiO(2); Water treatment; Water
purification
ID FISCHER-TROPSCH SYNTHESIS; CATALYSTS; PHOTOCATALYSIS; NANOPARTICLES;
DEGRADATION; WATER; GENERATION; RADICALS; HYDROGEN; SUPPORT
AB Sulfate radical-based advanced oxidation technologies (SR-AOTs) are attracting considerable attention due to the high oxidizing ability of SRs to degrade organic pollutants in aqueous environments. This study was carried out to respond to current concerns and challenges in SR-AOTs, including (i) need of heterogeneous activation of sulfate salts using transition metal oxides, (ii) nanoscaling of the metal oxide catalysts for high catalytic activity and promising properties with respect to leaching, and (iii) easy removal and recovery of the catalytic materials after their applications for water and wastewater treatments. In this study, we report a novel approach of using Fe-Co mixed oxide nanocatalysts for the heterogeneous activation of peroxymonosulfate (PMS) to generate SRs targeting the decomposition of 2,4-dichlorophenol, and especially focus on some synthesis parameters such as calcination temperature, Fe/Co contents, and TiO(2) support. The physicochemical properties of the catalysts were investigated using porosimetry, XRD, HR-TEM, H(2)-TPR, and XPS. Ferromagnetic CoFe(2)O(4) composites formed by thermal oxidation of a mixed phase of Fe and Co exhibited significant implications for the efficient and environmentally friendly activation of PMS, including(i) the cobalt species in CoFe(2)O(4) are of Co(II), unlike Co(3)O(4) showing some detrimental effects of Co(III) on the PMS activation, (ii) CoFe(2)O(4) possesses suppressed Co leaching properties due to strong Fe-Co interactions (i.e. Fe-Co linkages), and (iii) Fe-Co catalysts in form of CoFe(2)O(4) are easier to recover due to the unique ferromagnetic nature of CoFe(2)O(4). In addition, the presence of Fe was found to be beneficial for enriching hydroxyl group content on the Fe-Co catalyst surface, which is believed to facilitate the formation of Co(II)-OH complexes that are vital for heterogeneous PMS activation. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Choi, Hyeok; Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Yang, Qiujing; Dionysiou, Dionysios D.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
RP Al-Abed, SR (reprint author), US EPA, Natl Risk Management Res Lab, 26W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM al-abed.souhail@epa.gov; dionysios.d.dionysiou@uc.edu
RI Yang, Qiujing/G-1954-2011
FU National Science Foundation through a CAREER Award [BES-0448117];
National Risk Management Research Laboratory of EPA, Cincinnati, Ohio
[EP-C-05-056]
FX The authors are grateful to the National Science Foundation through a
CAREER Award (BES-0448117), to DuPont through a Young Professor Award to
D.D. Dionysiou, and the National Risk Management Research Laboratory of
EPA, Cincinnati, Ohio for financial support for this study
(EP-C-05-056). This paper has not been subjected to internal policy
review of the U.S. Environmental Protection Agency (EPA). Therefore, the
research results do not necessarily reflect the views of the agency or
its policy. Mention of trade names and commercial products does not
constitute endorsement or recommendation for use.
NR 33
TC 130
Z9 130
U1 18
U2 154
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0926-3373
J9 APPL CATAL B-ENVIRON
JI Appl. Catal. B-Environ.
PD MAY 20
PY 2009
VL 88
IS 3-4
BP 462
EP 469
DI 10.1016/j.apcatb.2008.10.013
PG 8
WC Chemistry, Physical; Engineering, Environmental; Engineering, Chemical
SC Chemistry; Engineering
GA 452BA
UT WOS:000266513400026
ER
PT J
AU Johansen, AMW
Wilcox, AJ
Lie, RT
Andersen, LF
Drevon, CA
AF Johansen, Anne Marte W.
Wilcox, Allen J.
Lie, Rolv T.
Andersen, Lene F.
Drevon, Christian A.
TI Maternal Consumption of Coffee and Caffeine-containing Beverages and
Oral Clefts: A Population-based Case-Control Study in Norway
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE caffeine; cleft lip; cleft palate; coffee; pregnancy
ID PLASMA HOMOCYSTEINE; HEALTHY-VOLUNTEERS; OROFACIAL CLEFTS; RISK;
ALCOHOL; SMOKING; COHORT; TRIAL; GENES
AB A large, population-based case-control study of facial clefts was carried out in Norway between 1996 and 2001. The study included 573 cases-025EF377 with cleft lip with or without cleft palate and 196 with cleft palate only-025EFand 763 randomly selected controls. Maternal consumption of coffee and other caffeine-containing beverages in early pregnancy was recorded shortly after birth. Compared with that for no coffee consumption, the adjusted odds ratios for cleft lip with or without cleft palate were 1.39 (95% confidence interval: 1.01, 1.92) for less than 3 cups a day and 1.59 (95% confidence interval: 1.05, 2.39) for 3 cups or more. Coffee consumption was not associated with risk of cleft palate only (for >= 3 cups vs. none, adjusted odds ratio = 0.96, 95% confidence interval: 0.55, 1.67). Tea consumption was associated with a reduced odds ratio of both cleft lip with or without cleft palate and cleft palate only. There was little evidence of an association between caffeine exposure and clefts when all sources of caffeine were considered. Adjustment for known confounding factors in general had minor effects on risk estimates. Still, the authors could not rule out the possibility of uncontrolled confounding by factors associated with the habit of drinking coffee.
C1 [Johansen, Anne Marte W.; Andersen, Lene F.; Drevon, Christian A.] Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0316 Oslo, Norway.
[Wilcox, Allen J.] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Durham, NC USA.
[Lie, Rolv T.] Univ Bergen, Sect Epidemiol & Med Stat, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway.
[Lie, Rolv T.] Norwegian Inst Publ Hlth, Med Birth Registry Norway, Bergen, Norway.
RP Johansen, AMW (reprint author), Univ Oslo, Inst Basic Med Sci, Dept Nutr, POB 1046, N-0316 Oslo, Norway.
EM a.m.w.johansen@medisin.uio.no
RI Drevon, Christian /F-6012-2010;
OI Wilcox, Allen/0000-0002-3376-1311
FU Research Council of Norway [166026/V50]; Freia Medical Foundation;
Throne-Holst Foundation for Nutrition Research; Faculty of Medicine,
University of Oslo, Oslo, Norway; Nutrigenomics, Network of Excellence,
FP6, Food Quality and Safety [NuGO FP6-506360]; Intramural Research
Program of the National Institutes of Health; National Institute of
Environmental Health Sciences
FX This work was supported by the Research Council of Norway (grant
166026/V50); the Freia Medical Foundation; the Throne-Holst Foundation
for Nutrition Research; the thematic area of perinatal nutrition,
Faculty of Medicine, University of Oslo, Oslo, Norway; and
Nutrigenomics, Network of Excellence, FP6, Food Quality and Safety (NuGO
FP6-506360). This research was supported in part by the Intramural
Research Program of the National Institutes of Health, National
Institute of Environmental Health Sciences.
NR 23
TC 12
Z9 13
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD MAY 15
PY 2009
VL 169
IS 10
BP 1216
EP 1222
DI 10.1093/aje/kwp040
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 440ZX
UT WOS:000265739600007
PM 19342400
ER
PT J
AU Huang, J
Dattilo, LK
Rajagopal, R
Liu, Y
Kaartinen, V
Mishina, Y
Deng, CX
Umans, L
Zwijsen, A
Roberts, AB
Beebe, DC
AF Huang, Jie
Dattilo, Lisa K.
Rajagopal, Ramya
Liu, Ying
Kaartinen, Vesa
Mishina, Yuji
Deng, Chu-Xia
Umans, Lieve
Zwijsen, An
Roberts, Anita B.
Beebe, David C.
TI FGF-regulated BMP signaling is required for eyelid closure and to
specify conjunctival epithelial cell fate
SO DEVELOPMENT
LA English
DT Article
DE Eyelid closure; Conjunctival cell fate; c-Jun nuclear transport; BMP
signaling; FGF signaling; Mouse
ID LYMPHEDEMA-DISTICHIASIS SYNDROME; FORKHEAD/WINGED-HELIX GENE;
CONDITIONAL KNOCKOUT MICE; TRANSCRIPTION FACTORS; TGF-BETA; C-JUN;
FUNCTIONAL-CHARACTERIZATION; HAIR FOLLICLE; LEADING-EDGE; NEURAL CREST
AB There are conflicting reports about whether BMP signaling is required for eyelid closure during fetal development. This question was addressed using mice deficient in BMP or TGF beta signaling in prospective eyelid and conjunctival epithelial cells. Genes encoding two type I BMP receptors, the type II TGF beta receptor, two BMP- or two TGF beta-activated R-Smads or the co-Smad Smad4 were deleted from the ocular surface ectoderm using Cre recombinase. Only mice with deletion of components of the BMP pathway had an 'eyelid open at birth' phenotype. Mice lacking Fgf10 or Fgfr2 also have open eyelids at birth. To better understand the pathways that regulate BMP expression and function during eyelid development, we localized BMPs and BMP signaling intermediates in Fgfr2 and Smad4 conditional knockout (CKO) mice. We found that Fgfr2 was required for the expression of Bmp4, the normal distribution of Shh signaling and for preserving the differentiation of the conjunctival epithelium. FGF signaling also promoted the expression of the Wnt antagonist Sfrp1 and suppressed Wnt signaling in the prospective eyelid epithelial cells, independently of BMP function. Transcripts encoding Foxc1 and Foxc2, which were previously shown to be necessary for eyelid closure, were not detectable in Smad4(CKO) animals. c-Jun, another key regulator of eyelid closure, was present and phosphorylated in eyelid periderm cells at the time of fusion, but failed to translocate to the nucleus in the absence of BMP function. Smad4(CKO) mice also showed premature differentiation of the conjunctival epithelium, conjunctival hyperplasia and the acquisition of epidermal characteristics, including formation of an ectopic row of hair follicles in place of the Meibomian glands. A second row of eyelashes is a feature of human lymphedema-distichiasis syndrome, which is associated with mutations in FOXC2.
C1 [Huang, Jie; Dattilo, Lisa K.; Rajagopal, Ramya; Liu, Ying; Beebe, David C.] Washington Univ, Dept Ophthalmol & Visual Sci, St Louis, MO 63130 USA.
[Beebe, David C.] Washington Univ, Dept Cell Biol & Physiol, St Louis, MO 63130 USA.
[Kaartinen, Vesa] Univ So Calif, Childrens Hosp Los Angeles, Keck Sch Med, Dev Biol Program,Dept Pathol, Los Angeles, CA 90027 USA.
[Kaartinen, Vesa] Univ So Calif, Childrens Hosp Los Angeles, Keck Sch Med, Dev Biol Program,Dept Surg, Los Angeles, CA 90027 USA.
[Mishina, Yuji] Natl Inst Environm Hlth Sci, Reprod & Dev Toxicol Lab, Mol Dev Biol Grp, Res Triangle Pk, NC 27709 USA.
[Deng, Chu-Xia] NIDDK, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA.
[Umans, Lieve; Zwijsen, An] Dept Mol & Dev Genet, Lab Mol Biol Celgen, B-3000 Louvain, Belgium.
[Umans, Lieve; Zwijsen, An] Katholieke Univ Leuven, Ctr Human Genet, Lab Mol Biol Celgen, B-3000 Louvain, Belgium.
[Roberts, Anita B.] NCI, Lab Cell Regulat & Carcinogenesis, NIH, Bethesda, MD 20892 USA.
RP Beebe, DC (reprint author), Washington Univ, Dept Ophthalmol & Visual Sci, St Louis, MO 63130 USA.
EM Beebe@vision.wustl.edu
RI Huang, Jie/D-7728-2014; deng, chuxia/N-6713-2016;
OI Kaartinen, Vesa/0000-0002-9432-510X
FU NIH [EY04853, EY02687]; Prevent Blindness to the Department of
Ophthalmology and Visual Sciences
FX The authors are indebted to Drs Zhen Mahoney and Jeff Miner for
generously sharing reagents, for many suggestions on the technical
aspects of this work and for assistance in editing. Belinda McMahan and
Jean Jones prepared the histological sections and Dr Claudia Garcia
provided guidance with the Fgfr2 conditional knockouts, which were
generously provided by Dr David Ornitz, Washington University, St Louis.
The Psen1 and Psen2 floxed and mutant mice were generously provided by
Dr J. Shen, Brigham and Women's Hospital, Boston, MA and Dr Raphael
Kopan, Washington University, St Louis. Drs Peter Gruss and Ruth
Ashery-Padan generated and provided the Le-Cre mice. Research was
supported by NIH grant EY04853 (D. C. B.) and NIH Core Grant P30 EY02687
and an unrestricted grant from Research to Prevent Blindness to the
Department of Ophthalmology and Visual Sciences. Deposited in PMC for
release after 12 months.
NR 52
TC 48
Z9 52
U1 0
U2 14
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
CAMBS, ENGLAND
SN 0950-1991
J9 DEVELOPMENT
JI Development
PD MAY 15
PY 2009
VL 136
IS 10
BP 1741
EP 1750
DI 10.1242/dev.034082
PG 10
WC Developmental Biology
SC Developmental Biology
GA 438AV
UT WOS:000265529200016
PM 19369394
ER
PT J
AU Peterson, SA
Ralston, NVC
Peck, DV
Van Sickle, J
Robertson, JD
Spate, VL
Morris, JS
AF Peterson, Spencer A.
Ralston, Nicholas V. C.
Peck, David V.
Van Sickle, John
Robertson, J. David
Spate, Vickie L.
Morris, J. Steven
TI How Might Selenium Moderate the Toxic Effects of Mercury in Stream Fish
of the Western US?
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID FRESH-WATER FISH; CHEMICAL FORM; RIVER-BASIN; IN-VITRO; METHYLMERCURY;
TISSUE; LAKES; VARIABILITY; ORGANISMS; NUTRITION
AB The ability of selenium (Se) to moderate mercury (Hg) toxicity is well established in the literature. Mercury exposures that might otherwise produce toxic effects are counteracted by Se, particularly when Se:Hg molar ratios approach or exceed 1. We analyzed whole body Se and Hg concentrations in 468 fish representing 40 species from 137 sites across 12 western U.S. states. The fish samples were evaluated relative to a published wildlife protective Hg threshold (0.1 mu g Hg.g(-1) wet wt), the current tissue based methylmercury (MeHg) water quality criterion (WQC) for the protection of humans (0.3 mu g Hg.g(-1) wet wt) and to presumed protections against Hg toxicity when Se:Hg molar ratios are > 1. A large proportion (56%) of our total fish sample exceeded the wildlife Hg threshold, whereas a smaller, but significant proportion (12%), exceeded the MeHg WQC. However, 97.5% of the total fish sample contained more Se than Hg (molar ratio > 1) leaving only 2.5% with Se: Hg ratios <1. All but one of the fish with Se:Hg <1, were of the genus Ptychochelius (pikeminnow). Scientific literature on Se counteracting Hg toxicity and our finding that 97.5% of the freshwater fish in our survey have sufficient Se to potentially protect them and their consumers against Hg toxicity suggests that Se in fish tissue (Se:Hg molar ratio) must be considered when assessing the potential toxic effects of Hg.
C1 [Peterson, Spencer A.; Peck, David V.; Van Sickle, John] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Ralston, Nicholas V. C.] Univ N Dakota, Energy & Environm Res Ctr, Grand Forks, ND 58202 USA.
[Robertson, J. David; Spate, Vickie L.; Morris, J. Steven] Univ Missouri, Dept Chem & Res Reactor, Columbia, MO 65211 USA.
RP Peterson, SA (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
EM peterson.spencer@epa.gov
OI Ralston, Nicholas/0000-0001-7686-2932
FU U.S. Environmental Protection Agency [CR830929-01]
FX The information in this document has been funded wholly (or in part) by
the U.S. Environmental Protection Agency as part of the Environmental
Monitoring and Assessment Program (EMAP). It has been subjected to
technical and policy review by the National Health and Environmental
Effects Research Laboratory's Western Ecology Division and approved for
publication. Approval does not signify that the contents reflect the
views of the Agency, nor does mention of trade names or commercial
products constitute endorsement or recommendation for use. N.V.C.R. was
supported by the U.S. Environmental Protection Agency through grant
CR830929-01 to the University of North Dakota Energy and Environmental
Research Center. We thank the EMAP field crews who collected fish from
the 12 western states. GIS support for the sampling design was provided
under Contract 68-W01-032 to Computer Sciences Corporation. Support for
fish tissue sample preparation at WED-Corvallis was provided through
Contracts 68-D06-005 and EP-D-06-013 to Dynamac, Inc. Jason Schacher and
Rick King (Dynamac, Inc.) performed the Hg analyses. All Se analyses
were performed at the University of Missouri-Columbia Research Reactor
Center under Contract EPO7R000069. In addition to the above persons and
entities, we thank Dennis Lemly, Dixon Landers, Bob Ozretich, Anne
Fairbrother, Jeff Bigler, Rita Schoeny, Kate Mahaffey, Edward Ohanian,
Charles Delos, and three anonymous reviewers who provided valuable
comments on an earlier draft.
NR 49
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U1 2
U2 48
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAY 15
PY 2009
VL 43
IS 10
BP 3919
EP 3925
DI 10.1021/es803203g
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 445JI
UT WOS:000266046700081
PM 19544908
ER
PT J
AU Katz, LM
Frank, JE
Dvorak, A
Finch, A
Szymanowski, A
Gordon, CJ
AF Katz, Laurence M.
Frank, Jonathan E.
Dvorak, Anne
Finch, Alex
Szymanowski, Adam
Gordon, Christopher J.
TI Independence of brain and trunk temperature during hypothermic
preconditioning in rats
SO JOURNAL OF NEUROSCIENCE METHODS
LA English
DT Article
DE Hypothermia; Hypothermic preconditioning; Hyperthermia; Telemetry;
Temperature
ID VITRO SIMULATED ISCHEMIA; FREELY MOVING RODENTS; BODY-TEMPERATURE;
CEREBELLAR SLICES; CORE TEMPERATURE; NEURONAL DAMAGE; CARDIAC-ARREST;
TOLERANCE; HIPPOCAMPUS; ANESTHESIA
AB Hypothermic preconditioning is rapid cooling and warming to induce tolerance to ischemia. The purpose of the study was to examine differences in brain and trunk temperature during hypothermic preconditioning.
Methods: Rats (n = 18) were implanted with telemetric probes for simultaneous measure of brain and trunk temperature. Hypothermic preconditioning was produced by exposing rats to cool and warm environments that produced rapid cooling to 30 degrees C and warming to 35 degrees C.
Results: Brain temperature was warmer (37.56 +/- 0.45 degrees C) than trunk (37.17 +/- 0.29 degrees C) temperature in unanesthetized, free roaming rats at room temperature (t-test p = 0.04). The brain cooled (0.59 +/- 0.1 degrees C/min) quicker than the trunk (0.44 +/- 0.19 degrees C/min) during cooling cycles of hypothermic preconditioning and the brain (0.28 +/- 0.04 degrees C/min) warmed quicker than the trunk (0.18 +/- 0.07 degrees C/min) during the warming cycle of hypothermic preconditioning (t-test p < 0.0001). When the trunk temperature probe was designated to reach the target temperature of 35 degrees C during warming, the brain temperature (38.1 +/- 0.44 degrees C) was warmer than trunk temperature (34.95 +/- 0.16 degrees C) during the peak of warming (t-test p < 0.0001).
Conclusion: The brain cools and warms quicker than the trunk during hypothermic preconditioning. Failure to anticipate these differences could lead to unrecognized brain hyperthermia during warming. Appreciation of differences in rates of change between brain and trunk temperature may be important when designing hypothermic preconditioning experiments. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Katz, Laurence M.; Frank, Jonathan E.; Dvorak, Anne; Finch, Alex; Szymanowski, Adam] Univ N Carolina, Sch Med, Dept Emergency Med, Chapel Hill, NC 27599 USA.
[Gordon, Christopher J.] US EPA, Div Expt Biol & Toxicol, Div Neurotoxicol, Res Triangle Pk, NC 27709 USA.
RP Katz, LM (reprint author), Univ N Carolina, Sch Med, Dept Emergency Med, CB 7594,Neurosci Hosp Ground Floor,101 Manning Dr, Chapel Hill, NC 27599 USA.
EM Lkatz@med.unc.edu; jfrank@med.unc.edu; dvorak@email.unc.edu;
asfinch@email.unc.edu; szymanow@email.unc.edu;
Gordon.Christopher@epamail.epa.gov
FU University of North Carolina Alumni Endowment Fund; University Research
Council Award
FX The study was funded in part by the University of North Carolina Alumni
Endowment Fund (PI Katz) and University Research Council Award (PI
Katz). A special thanks to Dr. Eric Lock and Dr. Steven Marron for
statistical analysis.
NR 35
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0270
J9 J NEUROSCI METH
JI J. Neurosci. Methods
PD MAY 15
PY 2009
VL 179
IS 2
BP 179
EP 183
DI 10.1016/j.jneumeth.2009.01.025
PG 5
WC Biochemical Research Methods; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 438VZ
UT WOS:000265585400004
PM 19428525
ER
PT J
AU Kumar, D
Reddy, VB
Varma, RS
AF Kumar, Dalip
Reddy, V. Buchi
Varma, Rajender S.
TI A facile and regioselective synthesis of 1,4-disubstituted
1,2,3-triazoles using click chemistry
SO TETRAHEDRON LETTERS
LA English
DT Article
DE alpha-Tosyloxy ketones; 1,4-Disubstituted 1,2,3-triazoles; Click
chemistry; Nitrogen heterocycles; Copper iodide
ID DRUG DISCOVERY; AZIDES; ALKYNES
AB The reaction of alpha-tosyloxy ketones, sodium azide, and terminal alkynes in presence of copper(1) in aqueous polyethylene glycol afforded regioselectively 1,4-disubstituted 1,2,3-triazoles in good yield at ambient temperature. The one-pot exclusive formation of 1,4-disubstituted 1,2,3-triazoles involves in situ formation of alpha-azido ketones, followed by cycloaddition reaction with terminal alkyne. The generality of this one-pot method was demonstrated by synthesizing an array of diverse 1,4-disubstituted 1,2,3-triazoles. (c) 2009 Elsevier Ltd. All rights reserved.
C1 [Kumar, Dalip; Reddy, V. Buchi] Birla Inst Technol & Sci, Chem Grp, Pilani 333031, Rajasthan, India.
[Varma, Rajender S.] US EPA, Clean Proc Branch, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Kumar, D (reprint author), Birla Inst Technol & Sci, Chem Grp, Pilani 333031, Rajasthan, India.
EM dalipk@bits-pilani.ac.in; varma.rajender@epa.gov
FU DRDO, New Delhi [ERIP/ER/0505034/M/01/902]; Birla Institute of
Technology and Science, Pilani
FX Authors are grateful for the financial support received from DRDO, New
Delhi (Project No. ERIP/ER/0505034/M/01/902) and Birla Institute of
Technology and Science, Pilani.
NR 36
TC 66
Z9 66
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0040-4039
J9 TETRAHEDRON LETT
JI Tetrahedron Lett.
PD MAY 6
PY 2009
VL 50
IS 18
BP 2065
EP 2068
DI 10.1016/j.tetlet.2009.02.107
PG 4
WC Chemistry, Organic
SC Chemistry
GA 431HS
UT WOS:000265052800009
ER
PT J
AU Ankley, GT
Bencic, DC
Breen, MS
Collette, TW
Conolly, RB
Denslow, ND
Edwards, SW
Ekman, DR
Garcia-Reyero, N
Jensen, KM
Lazorchak, JM
Martinovic, D
Miller, DH
Perkins, EJ
Orlando, EF
Villeneuve, DL
Wang, RL
Watanabe, KH
AF Ankley, Gerald T.
Bencic, David C.
Breen, Michael S.
Collette, Timothy W.
Conolly, Rory B.
Denslow, Nancy D.
Edwards, Stephen W.
Ekman, Drew R.
Garcia-Reyero, Natalia
Jensen, Kathleen M.
Lazorchak, James M.
Martinovic, Dalma
Miller, David H.
Perkins, Edward J.
Orlando, Edward F.
Villeneuve, Daniel L.
Wang, Rong-Lin
Watanabe, Karen H.
TI Endocrine disrupting chemicals in fish: Developing exposure indicators
and predictive models of effects based on mechanism of action
SO AQUATIC TOXICOLOGY
LA English
DT Article
DE Fish; EDC; Toxicity; MOA; Model; Genomics
ID MINNOW PIMEPHALES-PROMELAS; TERM REPRODUCTION ASSAY; FATHEAD MINNOW;
RISK-ASSESSMENT; BIOCHEMICAL RESPONSES; GENE NETWORKS; EXPRESSION;
STEROIDOGENESIS; KETOCONAZOLE; POPULATION
AB Knowledge of possible toxic mechanisms (or modes) of action (MOA) of chemicals can provide valuable insights as to appropriate methods for assessing exposure and effects, thereby reducing uncertainties related to extrapolation across species, endpoints and chemical structure. However, MOA-based testing seldom has been used for assessing the ecological risk of chemicals. This is in part because past regulatory mandates have focused more on adverse effects of chemicals (reductions in survival, growth or reproduction) than the pathways through which these effects are elicited. A recent departure from this involves endocrine-disrupting chemicals (EDCs), where there is a need to understand both MOA and adverse outcomes. To achieve this understanding, advances in predictive approaches are required whereby mechanistic changes caused by chemicals at the molecular level can be translated into apical responses meaningful to ecological risk assessment. In this paper we provide an overview and illustrative results from a large, integrated project that assesses the effects of EDCs on two small fish models, the fathead minnow (Pimephales promelas) and zebrafish (Danio rerio). For this work a systems-based approach is being used to delineate toxicity pathways for 12 model EDCs with different known or hypothesized toxic MOA. The studies employ a combination of state-of-the-art genomic (transcriptomic, proteomic, metabolomic), bioinformatic and modeling approaches, in conjunction with whole animal testing, to develop response linkages across biological levels of organization. This understanding forms the basis for predictive approaches for species, endpoint and chemical extrapolation. Although our project is focused specifically on EDCs in fish, we believe that the basic conceptual approach has utility for systematically assessing exposure and effects of chemicals with other MOA across a variety of biological systems. Published by Elsevier B.V.
C1 [Ankley, Gerald T.; Jensen, Kathleen M.; Martinovic, Dalma; Villeneuve, Daniel L.] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA.
[Bencic, David C.; Lazorchak, James M.; Wang, Rong-Lin] US EPA, Natl Exposure Res Lab, Cincinnati, OH USA.
[Breen, Michael S.; Conolly, Rory B.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC USA.
[Collette, Timothy W.; Ekman, Drew R.] US EPA, Natl Exposure Res Lab, Athens, GA USA.
[Denslow, Nancy D.; Garcia-Reyero, Natalia] Univ Florida, Gainesville, FL USA.
[Edwards, Stephen W.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC USA.
[Miller, David H.] US EPA, Natl Hlth & Environm Effects Res Lab, Grosse Ile, MI USA.
[Perkins, Edward J.] US Engineer Res & Dev Ctr, Vicksburg, MS USA.
[Orlando, Edward F.] Univ Maryland, College Pk, MD 20742 USA.
[Watanabe, Karen H.] Oregon Hlth & Sci Univ, Beaverton, OR USA.
RP Ankley, GT (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA.
EM ankley.gerald@epa.gov
OI Lazorchak, James/0000-0002-7354-7571; Martinovic-Weigelt,
Dalma/0000-0002-9973-4965
FU USEPA National Center for Computational Toxicology; USEPA National
Center for Environmental Research; US Army Environmental Quality
Installations Program
FX This work was supported in part by the USEPA National Center for
Computational Toxicology, a grant from the USEPA National Center for
Environmental Research to the University of Florida, and the US Army
Environmental Quality Installations Program. The manuscript has been
reviewed in accordance with USEPA guidelines; however, the views
expressed are those of the authors and do not necessarily reflect USEPA
policy. Permission was granted by the Chief of Engineers to publish this
information.
NR 54
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Z9 135
U1 7
U2 106
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-445X
J9 AQUAT TOXICOL
JI Aquat. Toxicol.
PD MAY 5
PY 2009
VL 92
IS 3
BP 168
EP 178
DI 10.1016/j.aquatox.2009.01.013
PG 11
WC Marine & Freshwater Biology; Toxicology
SC Marine & Freshwater Biology; Toxicology
GA 447IG
UT WOS:000266184200008
PM 19261338
ER
PT J
AU Gohlke, JM
Thomas, R
Zhang, YQ
Rosenstein, MC
Davis, AP
Murphy, C
Becker, KG
Mattingly, CJ
Portier, CJ
AF Gohlke, Julia M.
Thomas, Reuben
Zhang, Yonqing
Rosenstein, Michael C.
Davis, Allan P.
Murphy, Cynthia
Becker, Kevin G.
Mattingly, Carolyn J.
Portier, Christopher J.
TI Genetic and environmental pathways to complex diseases
SO BMC SYSTEMS BIOLOGY
LA English
DT Article
ID INFLAMMATION-RELATED GENES; EXPRESSION PROFILES; SYSTEMATIC
METAANALYSES; INTERACTION NETWORKS; RETINOIC ACID; PPAR-GAMMA; GENOME;
OBESITY; DATABASE; RISK
AB Background: Pathogenesis of complex diseases involves the integration of genetic and environmental factors over time, making it particularly difficult to tease apart relationships between phenotype, genotype, and environmental factors using traditional experimental approaches.
Results: Using gene-centered databases, we have developed a network of complex diseases and environmental factors through the identification of key molecular pathways associated with both genetic and environmental contributions. Comparison with known chemical disease relationships and analysis of transcriptional regulation from gene expression datasets for several environmental factors and phenotypes clustered in a metabolic syndrome and neuropsychiatric subnetwork supports our network hypotheses. This analysis identifies natural and synthetic retinoids, antipsychotic medications, Omega 3 fatty acids, and pyrethroid pesticides as potential environmental modulators of metabolic syndrome phenotypes through PPAR and adipocytokine signaling and organophosphate pesticides as potential environmental modulators of neuropsychiatric phenotypes.
Conclusion: Identification of key regulatory pathways that integrate genetic and environmental modulators define disease associated targets that will allow for efficient screening of large numbers of environmental factors, screening that could set priorities for further research and guide public health decisions.
C1 [Gohlke, Julia M.; Thomas, Reuben; Portier, Christopher J.] Natl Inst Environm Hlth Sci, Environm Syst Biol Grp, Mol Toxicol Lab, Res Triangle Pk, NC 27709 USA.
[Zhang, Yonqing; Becker, Kevin G.] NIA, Gene Express & Genom Unit, NIH, Baltimore, MD 21224 USA.
[Rosenstein, Michael C.; Davis, Allan P.; Murphy, Cynthia; Mattingly, Carolyn J.] Mt Desert Isl Biol Lab, Dept Bioinformat, Salsbury Cove, ME 04672 USA.
RP Portier, CJ (reprint author), Natl Inst Environm Hlth Sci, Environm Syst Biol Grp, Mol Toxicol Lab, Res Triangle Pk, NC 27709 USA.
EM gohlkej@niehs.nih.gov; thomasr3@niehs.nih.gov; zhangyon@grc.nia.nih.gov;
mcr@mdibl.org; apdavis@mdibl.org; cmurphy@mdibl.org;
beckerk@grc.nia.nih.gov; cmattin@mdibl.org; portier@niehs.nih.gov
RI Portier, Christopher/A-3160-2010;
OI Portier, Christopher/0000-0002-0954-0279; Gohlke,
Julia/0000-0002-6984-2893; Becker, Kevin/0000-0002-6794-6656
FU NIH, National Institute of Environmental Health Sciences; National
Institute of Aging; NIEHS [5R01ES014065-02]
FX This research was supported in part by the Intramural Research Program
of the NIH, National Institute of Environmental Health Sciences (J.G.,
R.T., C.P.) and National Institute of Aging (Y.Z., K.B.) as well as
NIEHS extramural funding under grant 5R01ES014065-02 ( M. R., A.D., C.M.
and C.J.M.).
NR 78
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U1 1
U2 12
PU BIOMED CENTRAL LTD
PI LONDON
PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T
4LB, ENGLAND
SN 1752-0509
J9 BMC SYST BIOL
JI BMC Syst. Biol.
PD MAY 5
PY 2009
VL 3
AR 46
DI 10.1186/1752-0509-3-46
PG 15
WC Mathematical & Computational Biology
SC Mathematical & Computational Biology
GA 444TA
UT WOS:000266002100001
PM 19416532
ER
PT J
AU Bloomer, BJ
Stehr, JW
Piety, CA
Salawitch, RJ
Dickerson, RR
AF Bloomer, Bryan J.
Stehr, Jeffrey W.
Piety, Charles A.
Salawitch, Ross J.
Dickerson, Russell R.
TI Observed relationships of ozone air pollution with temperature and
emissions
SO GEOPHYSICAL RESEARCH LETTERS
LA English
DT Article
ID EASTERN UNITED-STATES; NITROGEN-OXIDES EMISSIONS; URBAN; ENVIRONMENTS;
QUALITY; TRENDS; IMPACT
AB Higher temperatures caused by increasing greenhouse gas concentrations are predicted to exacerbate photochemical smog if precursor emissions remain constant. We perform a statistical analysis of 21 years of ozone and temperature observations across the rural eastern U. S. The climate penalty factor is defined as the slope of the ozone/temperature relationship. For two precursor emission regimes, before and after 2002, the climate penalty factor was consistent across the distribution of ozone observations. Prior to 2002, ozone increased by an average of similar to 3.2 ppbv/degrees C. After 2002, power plant NOx emissions were reduced by 43%, ozone levels fell similar to 10%, and the climate penalty factor dropped to similar to 2.2 ppbv/degrees C. NOx controls are effective for reducing photochemical smog and might lessen the severity of projected climate change penalties. Air quality models should be evaluated against these observations, and the climate penalty factor metric may be useful for evaluating the response of ozone to climate change. Citation: Bloomer, B. J., J. W. Stehr, C. A. Piety, R. J. Salawitch, and R. R. Dickerson (2009), Observed relationships of ozone air pollution with temperature and emissions, Geophys. Res. Lett., 36, L09803, doi: 10.1029/2009GL037308.
C1 [Bloomer, Bryan J.] US EPA, Washington, DC 20460 USA.
[Bloomer, Bryan J.; Stehr, Jeffrey W.; Piety, Charles A.; Salawitch, Ross J.; Dickerson, Russell R.] Univ Maryland, Dept Atmospher & Ocean Sci, College Pk, MD 20742 USA.
RP Bloomer, BJ (reprint author), US EPA, Washington, DC 20460 USA.
EM russ@atmos.umd.edu
RI Salawitch, Ross/B-4605-2009; Stehr, Jeffrey/F-2638-2010; Dickerson,
Russell/F-2857-2010
OI Salawitch, Ross/0000-0001-8597-5832; Stehr, Jeffrey/0000-0003-4840-6942;
Dickerson, Russell/0000-0003-0206-3083
FU US Environmental Protection Agency; Maryland Department of the
Environment; National Aeronautics and Space Administration
FX BJB was supported by the US Environmental Protection Agency. RRD, JWS
and CAP were supported by the Maryland Department of the Environment.
RJS was supported by the National Aeronautics and Space Administration.
The authors thank the US EPA CASTNET. We appreciate helpful discussions
with Sherri Hunt, Alan Leinbach, Elizabeth Weatherhead, and Darrell
Winner. We thank Loretta Mickley, Daniel Jacob and an anonymous reviewer
for their helpful comments. Statements in this publication reflect the
authors' professional views and opinions and should not be construed to
represent any determination or policy of the US EPA.
NR 21
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U1 5
U2 61
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0094-8276
J9 GEOPHYS RES LETT
JI Geophys. Res. Lett.
PD MAY 5
PY 2009
VL 36
AR L09803
DI 10.1029/2009GL037308
PG 5
WC Geosciences, Multidisciplinary
SC Geology
GA 443RQ
UT WOS:000265928300002
ER
PT J
AU Klemick, H
Leonard, KL
Masatu, MC
AF Klemick, Heather
Leonard, Kenneth L.
Masatu, Melkiory C.
TI Defining Access to Health Care: Evidence on the Importance of Quality
and Distance in Rural Tanzania
SO AMERICAN JOURNAL OF AGRICULTURAL ECONOMICS
LA English
DT Article
DE access to care; bypassing; health policy reform; health spending; rural
health care; Tanzania; vignettes
ID DEVELOPING-COUNTRIES; SERVICES; INDIA; POOR; FACILITIES; VIGNETTES;
POVERTY; CENTERS; DOCTORS
AB We examine the implications of health-seeking behavior on access to quality health care using a unique dataset that combines a household survey from rural Tanzania with the location and quality of all health facilities available to households. Patients do not always visit the nearest facility, but choose from among multiple facilities, improving the quality of care they receive by bypassing low quality facilities. Recognizing this behavior alters the projected benefits to health interventions, reducing the value of focusing on the staff qualifications and increasing the value of focusing on travel time and the motivation of current staff.
C1 [Klemick, Heather] US EPA, Natl Ctr Environm Econ, College Pk, MD USA.
[Leonard, Kenneth L.] Univ Maryland, Dept Agr & Resource Econ, College Pk, MD 20742 USA.
[Masatu, Melkiory C.] Ctr Educ Dev Hlth, Arusha, Tanzania.
RP Klemick, H (reprint author), US EPA, Natl Ctr Environm Econ, College Pk, MD USA.
RI Leonard, Kenneth L./F-9241-2011
OI Leonard, Kenneth L./0000-0002-0785-7774
FU NSF [00-95235]; World Bank
FX This work was funded by NSF Grant 00-95235 and The World Bank and was
completed with the assistance of R. Darabe, M. Kyande, S. Masanja, H. M.
Mvungi, and J. Msolla. We extend our appreciation to the Commission for
Science and Technology (COSTECH, Tanzania) for granting permission to
perform this research. This paper has benefited from extensive
conversations with Jishnu Das, as well as seminar participants at the
London School of Hygiene and Tropical Medicine. The views expressed in
this article represent those of the authors alone, not the U.S.
Environmental Protection Agency. No official agency endorsement should
be inferred.
NR 39
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U1 1
U2 13
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0002-9092
J9 AM J AGR ECON
JI Am. J. Agr. Econ.
PD MAY
PY 2009
VL 91
IS 2
BP 347
EP 358
DI 10.1111/j.1467-8276.2009.01252.x
PG 12
WC Agricultural Economics & Policy; Economics
SC Agriculture; Business & Economics
GA 428BQ
UT WOS:000264823400005
ER
PT J
AU Iliff, JJ
Wang, RK
Zeldin, DC
Alkayed, NJ
AF Iliff, Jeffrey J.
Wang, Ruikang
Zeldin, Darryl C.
Alkayed, Nabil J.
TI Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral
vessels
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE cerebral blood flow regulation; cytochrome P-450 epoxygenase;
epoxyeicosatrienoic acid; soluble epoxide hydrolase; perivascular nerves
ID SOLUBLE EPOXIDE HYDROLASE; ARACHIDONIC-ACID EPOXYGENASE; ASTROCYTIC
EPOXYEICOSATRIENOIC ACID; CORTICAL FUNCTIONAL HYPEREMIA; NITRIC-OXIDE;
BLOOD-FLOW; PERIVASCULAR NERVES; ENDOTHELIAL-CELLS; RAT; STIMULATION
AB Iliff JJ, Wang R, Zeldin DC, Alkayed NJ. Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels. Am J Physiol Heart Circ Physiol 296: H1352-H1363, 2009. First published March 20, 2009; doi:10.1152/ajpheart.00950.2008.-Epoxyeicosatrienoic acids (EETs) are potent vasodilators produced from arachidonic acid by cytochrome P-450 (CYP) epoxygenases and metabolized to vicinal diols by soluble epoxide hydrolase (sEH). In the brain, EETs are produced by astrocytes and the vascular endothelium and are involved in the control of cerebral blood flow (CBF). Recent evidence, however, suggests that epoxygenases and sEH are present in perivascular vasodilator nerve fibers innervating the cerebral surface vasculature. In the present study, we tested the hypothesis that EETs are nerve-derived relaxing factors in the cerebral circulation. We first traced these fibers by retrograde labeling in the rat to trigeminal ganglia (TG) and sphenopalatine ganglia (SPG). We then examined the expression of CYP epoxygenases and sEH in these ganglia. RT-PCR and Western blot analysis identified CYP2J3 and CYP2J4 epoxygenase isoforms and sEH in both TG and SPG, and immunofluorescence double labeling identified CYP2J and sEH immunoreactivity in neuronal cell bodies of both ganglia. To evaluate the functional role of EETs in neurogenic vasodilation, we elicited cortical hyperemia by electrically stimulating efferent cerebral perivascular nerve fibers and by chemically stimulating oral trigeminal fibers with capsaicin. Cortical blood flow responses were monitored by laser-Doppler flowmetry. Local administration to the cortical surface of the putative EET antagonist 14,15-epoxyeicosa-5(Z)-enoic acid (30 mu mol/l) attenuated CBF responses to electrical and chemical stimulation. These results suggest that EETs are produced by perivascular nerves and play a role in neurogenic vasodilation of the cerebral vasculature. The findings have important implications to such clinical conditions as migraine, vasospasm after subarachnoid hemorrhage, and stroke.
C1 [Iliff, Jeffrey J.; Alkayed, Nabil J.] Oregon Hlth & Sci Univ, Dept Anesthesiol & Peri Operat Med, Portland, OR 97239 USA.
[Iliff, Jeffrey J.; Alkayed, Nabil J.] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97239 USA.
[Wang, Ruikang] Oregon Hlth & Sci Univ, Dept Biomed Engn, Portland, OR 97239 USA.
[Zeldin, Darryl C.] Natl Inst Environm Hlth Sci, Div Intramural Res, Natl Inst Hlth, Res Triangle Pk, NC USA.
RP Alkayed, NJ (reprint author), Oregon Hlth & Sci Univ, Dept Anesthesiol & Peri Operat Med, 3181 SW Sam Jackson Pk Rd,UHS 2, Portland, OR 97239 USA.
EM alkayedn@ohsu.edu
FU Vertex Pharmaceuticals; National Institutes of Health (NIH)
[F31-NS-060498, RO1-NS-044313, P01-NS-049210, 1-R01-HL-093140-01,
Z01-ES-025034]
FX This work was supported by an Oregon Health and Science University
Graduate Student Fellowship for the Neurobiology of Disease funded by
Vertex Pharmaceuticals; National Institutes of Health (NIH) Grants
F31-NS-060498 (to J. J. Iliff), RO1-NS-044313 and P01-NS-049210 (to N.
J. Alkayed), 1-R01-HL-093140-01 (to R. Wang), and Z01-ES-025034 (to D.
C. Zeldin); and the Intramural Research Program of the NIH (to D. C.
Zeldin).
NR 36
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U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAY
PY 2009
VL 296
IS 5
BP H1352
EP H1363
DI 10.1152/ajpheart.00950.2008
PG 12
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
Disease
SC Cardiovascular System & Cardiology; Physiology
GA 439WU
UT WOS:000265659100023
PM 19304946
ER
PT J
AU Salice, CJ
Miller, TJ
Roesijadi, G
AF Salice, Christopher J.
Miller, Thomas J.
Roesijadi, G.
TI Demographic Responses to Multigeneration Cadmium Exposure in Two Strains
of the Freshwater Gastropod, Biomphalaria glabrata
SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
ID POPULATION-GROWTH RATE; DAPHNIA-MAGNA; RISK-ASSESSMENT; PARAMETERS;
TOLERANCE; TOXICITY; METALS; ACCLIMATION; BIOKINETICS; ELASTICITY
AB A life table response experiment (LTRE) was used to quantify the population-level effects of continuous, multigeneration cadmium exposure on two strains of the freshwater gastropod, Biomphalaria glabrata: the parasite-resistant BS90 and parasite-susceptible NMRI strains. Snails were exposed to waterborne cadmium for three consecutive generations. Survival, growth, and reproduction were measured empirically and incorporated into a stage-based, deterministic population model. Cadmium significantly affected hatching success, time to maturity, and juvenile and adult survival in both strains. There were significant effects of generation on fecundity, hatching success, time to maturity and juvenile survival in NMRI, and time to maturity and adult survival in BS90. Cadmium significantly affected the population growth rate, lambda, in BS90. Cadmium, generation, and the cadmium x generation interaction had significant effects on lambda in NMRI. At the high cadmium exposure, lambda for NMRI showed a decrease from generation 1 to generation 2, followed by an increase from generation 2 to generation 3. The lambda value in high-cadmium BS90 steadily decreased over the three generations, while NMRI at this same concentration was similar to the controls. The results indicate that strain-specific differences in response to multigeneration cadmium exposure are evident in B. glabrata. Moreover, effects seen in the first generation are not necessarily indicative of effects in subsequent generations. Changes in lambda over the course of the three-generation exposure suggest that acclimation and/or adaptation to cadmium may have occurred, particularly in NMRI at the high cadmium exposure level.
C1 [Salice, Christopher J.] US EPA, OPP, EFED, Washington, DC 20460 USA.
[Salice, Christopher J.; Miller, Thomas J.; Roesijadi, G.] Univ Maryland, Chesapeake Biol Lab, Ctr Environm Sci, Solomons, MD 20688 USA.
[Roesijadi, G.] Pacific NW Natl Lab, Marine Sci Div, Sequim, WA 98382 USA.
RP Salice, CJ (reprint author), US EPA, OPP, EFED, 1200 Penn Ave NW 7507P, Washington, DC 20460 USA.
EM Salice.christopher@epa.gov; Miller@cbl.umces.edu; g.roesijadi@pnl.gov
RI Miller, Thomas/C-2129-2008
OI Miller, Thomas/0000-0001-8427-1614
FU NIH Training Grant [T32 ES-7263]; University of Maryland, Baltimore;
Graduate Student Association, University of Maryland, Baltimore
FX Support from the following organizations is acknowledged: NIH Training
Grant T32 ES-7263 to the Program in Toxicology, University of Maryland,
Baltimore, and Graduate Student Association, University of Maryland,
Baltimore. Fred Lewis of the Biomedical Research Institute kindly
provided snails and invaluable advice on the biology and husbandry of
Biomphalaria glabrata. This study was conducted at the University of
Maryland Center for Environmental Science, Chesapeake Biological
Laboratory. Contribution No. 4201 of the University of Maryland Center
for Environmental Science. U. S. Environmental Protection Agency is
current address of designated author and is not affiliated with this
research.
NR 30
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U1 0
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-4341
EI 1432-0703
J9 ARCH ENVIRON CON TOX
JI Arch. Environ. Contam. Toxicol.
PD MAY
PY 2009
VL 56
IS 4
BP 785
EP 795
DI 10.1007/s00244-008-9203-9
PG 11
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 430MT
UT WOS:000264993900018
PM 18712500
ER
PT J
AU Eder, B
Kang, DW
Mathur, R
Pleim, J
Yu, SC
Otte, T
Pouliot, G
AF Eder, Brian
Kang, Daiwen
Mathur, Rohit
Pleim, Jon
Yu, Shaocai
Otte, Tanya
Pouliot, George
TI A performance evaluation of the National Air Quality Forecast Capability
for the summer of 2007
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Air quality forecast model; Ozone; Evaluation
ID CMAQ MODELING SYSTEM; ETA-MODEL; OZONE; BASIN
AB This paper provides a performance evaluation of the real-time, CONUS-scale National Air Quality Forecast Capability (NAQFC) that supported, in part, its transition into operational status. This evaluation focuses primarily on discrete forecasts for the maximum 8-h O(3) concentrations covering the 4-month period, June through September, 2007, using measurements obtained from EPA's AIRNow network. Results indicate that the 2007 NAQFC performed as well or better than previous configurations, despite the expansion of the forecast domain into the western half of the nation that is dominated by complex terrain. The mean, domain-wide, season-long correlation was 0.70. When examined over time, the domain-wide correlations exhibit a fairly consistent nature, with values exceeding 0.60 (0.70) over 90% (55%) of the days. The NAQFC systematically over-predicted the 8-h O(3) concentrations, continuing a trend established by earlier NAQFC configurations, though to a lesser degree. The summer-long mean forecast value of 53.2 ppb was 4.2 ppb higher than the observed value, resulting in a domain-wide Normalized Mean Bias (NMB) of 8.7%. Most of the over-prediction is associated with observed concentrations less than 50 ppb. In fact the model tends to under-predict when concentrations exceed 70 ppb. As with the bias, the error associated with the latest configuration was also lower. The summer-long Root Mean Square Error of 13.0 ppb (Normalized Mean Error (NME) = 20.4%) represented marked improvements over earlier forecasts. Examination of the spatial distribution of both the NMB and NME reveals that the NAQFC was generally within 25% for the NME and 25% for the NMB over a majority of the domain. Several areas of poorer performance, where the NMB and NME often exceed 25% and in some cases 50%, were noted. These areas include southern California, where the NAQFC tended to under-predict concentrations (especially on weekends) and the southeast Atlantic and Gulf coasts regions, where the model over-predicted. Subsequent analysis revealed that the incorrect temporal allocation of precursor emissions was likely the source of the under-prediction in southern California, while inaccurate simulation of PBL heights likely contributed to the over-prediction in the coastal regions. Published by Elsevier Ltd.
C1 [Eder, Brian; Mathur, Rohit; Pleim, Jon; Otte, Tanya; Pouliot, George] US EPA, Atmospher Modeling Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Kang, Daiwen; Yu, Shaocai] Sci & Technol Corp, Hampton, VA 23666 USA.
RP Eder, B (reprint author), US EPA, Atmospher Modeling Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM eder.brian@epa.gov
RI yu, shaocai/G-7806-2011; yu, shaocai/F-1394-2014; Pleim, Jonathan
Pleim/C-1331-2017;
OI Pleim, Jonathan Pleim/0000-0001-6190-6082; Spero,
Tanya/0000-0002-1600-0422; Pouliot, George/0000-0003-3406-4814
FU United States Environmental Protection Agency
FX The United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research described here.
It has been subjected to Agency's administrative review and approved for
publication.
NR 23
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U1 1
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD MAY
PY 2009
VL 43
IS 14
BP 2312
EP 2320
DI 10.1016/j.atmosenv.2009.01.033
PG 9
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 441ZN
UT WOS:000265809300010
ER
PT J
AU Chan, SSL
Copeland, WC
AF Chan, Sherine S. L.
Copeland, William C.
TI DNA polymerase gamma and mitochondrial disease: Understanding the
consequence of POLG mutations
SO BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
LA English
DT Article; Proceedings Paper
CT International Symposium on Mitchondrial Physiology and Pathology
CY JUN, 2008
CL Bari, ITALY
DE Mitochondria; Mitochondrial disease; DNA polymerase gamma; Mitochondrial
DNA replication; Oxidative stress
ID PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA; ALPERS-SYNDROME; CAG REPEAT;
SACCHAROMYCES-CEREVISIAE; MALE-INFERTILITY; ACCESSORY SUBUNIT; W748S
MUTATION; GENE POLG; POLYMORPHISM; DEFECTS
AB DNA polymerase gamma is the only known DNA polymerase in human mitochondria and is essential for mitochondrial DNA replication and repair. It is well established that defects in mtDNA replication lead to mitochondrial dysfunction and disease. Over 160 coding variations in the gene encoding the catalytic subunit of DNA polymerase gamma (POLG) have been identified. Our group and others have characterized a number of the more common and interesting mutations, as well as those disease mutations in the DNA polymerase gamma accessory subunit. We review the results of these studies, which provide clues to the mechanisms leading to the disease state. Published by Elsevier B.V.
C1 [Chan, Sherine S. L.; Copeland, William C.] Natl Inst Environm Hlth Sci, Mol Genet Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP Chan, SSL (reprint author), Natl Inst Environm Hlth Sci, Mol Genet Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
EM sherine.s.l.chan@gmail.com; copelan1@niehs.nih.gov
FU Intramural NIH HHS [Z01 ES065078-14, Z01 ES065080-13]; NIEHS NIH HHS
[1K99-ES015555-01, K99 ES015555, K99 ES015555-01, R00 ES015555]
NR 52
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U1 1
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0005-2728
J9 BBA-BIOENERGETICS
JI Biochim. Biophys. Acta-Bioenerg.
PD MAY
PY 2009
VL 1787
IS 5
BP 312
EP 319
DI 10.1016/j.bbabio.2008.10.007
PG 8
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 451MX
UT WOS:000266475400005
PM 19010300
ER
PT J
AU Chernoff, N
AF Chernoff, N.
TI Relationships of Maternal and Fetal Weight Changes in Developmental
Toxicology Bioassays
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Chernoff, N.] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 390
EP 390
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900028
ER
PT J
AU Kavlock, RJ
AF Kavlock, R. J.
TI Applications of Computational Toxicology to the Understanding of Risks
of Developmental Toxicity.
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Kavlock, R. J.] US EPA, Natl Ctr Computat Toxicol, ORD, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 393
EP 393
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900035
ER
PT J
AU Dix, DJ
AF Dix, D. J.
TI Identifying Toxicity Pathways With ToxCast High-Throughput Screening and
Applications to Predicting Developmental Toxicity
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Dix, D. J.] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 1
Z9 1
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 394
EP 394
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900039
ER
PT J
AU Barone, S
AF Barone, Jr S.
TI Overview of Vulnerability to Environmental Chemical Exposures
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Barone, Jr S.] US EPA, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 403
EP 403
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900050
ER
PT J
AU Knudsen, TB
Martin, MT
Kavlock, RJ
Judson, RS
Dix, DJ
Singh, AV
AF Knudsen, T. B.
Martin, M. T.
Kavlock, R. J.
Judson, R. S.
Dix, D. J.
Singh, A., V
TI Profiling Developmental Toxicity of 387 Environmental Chemicals Using
EPA's Toxicity Reference Database (ToxRefDB)
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Knudsen, T. B.; Martin, M. T.; Kavlock, R. J.; Judson, R. S.; Dix, D. J.] US EPA, NCCT, Res Triangle Pk, NC 27711 USA.
[Singh, A., V] Lockheed Martin, Res Triangle Pk, NC USA.
RI Singh, Amar/K-4400-2013
OI Singh, Amar/0000-0003-3780-8233
NR 0
TC 0
Z9 0
U1 2
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 406
EP 406
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900056
ER
PT J
AU Barrier, M
Jeffay, S
Nichols, HP
Slentz-Kesler, K
Hunter, ES
AF Barrier, M.
Jeffay, S.
Nichols, H. P.
Slentz-Kesler, K.
Hunter, E. S.
TI Development of an In Vitro Technique to Use Mouse Embryonic Stem Cells
(mESC) in Evaluating Effects of Xenobiotics
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Barrier, M.; Jeffay, S.; Nichols, H. P.; Hunter, E. S.] US EPA, Res Triangle Pk, NC 27711 USA.
[Slentz-Kesler, K.] Almac Diagnost, Durham, NC USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 414
EP 414
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900072
ER
PT J
AU Singh, AV
Knudsen, TB
AF Singh, A., V
Knudsen, T. B.
TI Implementation of a Flexible Tool for Automated Literature-Mining and
Knowledgebase Development (DevToxMine (TM))
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Knudsen, T. B.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Singh, A., V] Lockheed Martin, Res Triangle Pk, NC USA.
RI Singh, Amar/K-4400-2013
OI Singh, Amar/0000-0003-3780-8233
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 420
EP 420
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900082
ER
PT J
AU Hunter, ES
Hoopes, MR
Narotsky, MG
Simmons, JE
Nheerl, ORD
AF Hunter, E. S.
Hoopes, M. R.
Narotsky, M. G.
Simmons, J. E.
Nheerl, O. R. D.
TI Effects of Haloacetic Acid Mixtures on Mouse Development in Whole Embryo
Culture
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Hunter, E. S.; Hoopes, M. R.; Narotsky, M. G.; Simmons, J. E.; Nheerl, O. R. D.] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 1
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 424
EP 424
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900090
ER
PT J
AU Fenton, SE
Reiner, JL
Nakayama, SF
Delinsky, AD
Stanko, JP
Hines, EP
White, SS
Lindstrom, AB
Strynar, MJ
Petropoulou, SSE
AF Fenton, S. E.
Reiner, J. L.
Nakayama, S. F.
Delinsky, A. D.
Stanko, J. P.
Hines, E. P.
White, S. S.
Lindstrom, A. B.
Strynar, M. J.
Petropoulou, S. S. E.
TI Disposition of Perfluorooctanoic Acid (PFOA) in Pregnant and Lactating
CD-1 Mice and Their Pups
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Fenton, S. E.; Stanko, J. P.; Hines, E. P.; White, S. S.] US EPA, Reprod Toxicol Div, Natl Hlth & Environm Effects Res Lab, ORD, Res Triangle Pk, NC 27711 USA.
[Reiner, J. L.; Nakayama, S. F.; Petropoulou, S. S. E.] US EPA, ORISE, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab,ORD, Res Triangle Pk, NC 27711 USA.
[White, S. S.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
RI Reiner, Jessica/B-9169-2008; Nakayama, Shoji/B-9027-2008
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 432
EP 432
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900107
ER
PT J
AU Narotsky, MG
Best, DS
AF Narotsky, M. G.
Best, D. S.
TI Effects of Mixtures of Atrazine and Metabolites on Pregnancy Maintenance
in F344 Rats
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Narotsky, M. G.; Best, D. S.] US EPA, ORD, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 432
EP 432
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900106
ER
PT J
AU Brown, RC
Backus, G
Euling, SY
Foos, B
Makris, S
Moya, J
Olsen, M
Raffaele, K
Sonawane, B
Strong, J
AF Brown, R. C.
Backus, G.
Euling, S. Y.
Foos, B.
Makris, S.
Moya, J.
Olsen, M.
Raffaele, K.
Sonawane, B.
Strong, J.
TI Consideration of Susceptible Populations in Risk Assessment
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Brown, R. C.; Backus, G.; Euling, S. Y.; Foos, B.; Makris, S.; Moya, J.; Raffaele, K.; Sonawane, B.; Strong, J.] US EPA, Washington, DC 20460 USA.
[Olsen, M.] US EPA, New York, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 433
EP 433
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900108
ER
PT J
AU Abbott, BD
Das, KP
Wood, CR
Lau, C
AF Abbott, B. D.
Das, K. P.
Wood, C. R.
Lau, C.
TI PPAR alpha, PPAR beta, and PPAR gamma Expression in Prenatal and
Postnatal Mouse Tissues and an Evaluation of the Effects of
Perfluorooctanoic Acid (PFOA) on Peroxisome Proliferator-Activated
Receptor (PPAR) Expression
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Abbott, B. D.; Das, K. P.; Wood, C. R.; Lau, C.] US EPA, ORD, NHEERL, RTD, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 441
EP 441
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900123
ER
PT J
AU Makris, SL
Euling, SY
Brown, RC
Gray, LE
Wilson, V
Hotchkiss, A
Phang, W
Iyer, P
AF Makris, S. L.
Euling, S. Y.
Brown, R. C.
Gray, L. E.
Wilson, V
Hotchkiss, A.
Phang, W.
Iyer, P.
TI Mode of Action Analysis for Linuron - A Case Study
SO BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
LA English
DT Meeting Abstract
C1 [Makris, S. L.; Euling, S. Y.; Brown, R. C.; Hotchkiss, A.] US EPA, ORD, NCEA, Washington, DC 20460 USA.
[Gray, L. E.; Wilson, V] US EPA, ORD, NHEERL, Res Triangle Pk, NC 27711 USA.
[Phang, W.] US EPA, OPP, HED, Washington, DC 20460 USA.
[Iyer, P.] Calif EPA, OEHHA, Sacramento, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-0752
EI 1542-0760
J9 BIRTH DEFECTS RES A
JI Birth Defects Res. Part A-Clin. Mol. Teratol.
PD MAY
PY 2009
VL 85
IS 5
BP 454
EP 454
PG 1
WC Developmental Biology; Toxicology
SC Developmental Biology; Toxicology
GA 454PX
UT WOS:000266695900149
ER
PT J
AU Cekanova, M
Lee, SH
Donnell, RL
Sukhthankar, M
Eling, TE
Fischer, SM
Baek, SJ
AF Cekanova, Maria
Lee, Seong-Ho
Donnell, Robert L.
Sukhthankar, Mugdha
Eling, Thomas E.
Fischer, Susan M.
Baek, Seung Joon
TI Nonsteroidal Anti-inflammatory Drug-Activated Gene-1 Expression Inhibits
Urethane-Induced Pulmonary Tumorigenesis in Transgenic Mice
SO CANCER PREVENTION RESEARCH
LA English
DT Article
ID COLORECTAL-CANCER CELLS; BETA SUPERFAMILY MEMBER; GROWTH-FACTOR-BETA;
LUNG CARCINOGENESIS; CARCINOMA-CELLS; GAMMA LIGAND; NAG-1; PROTEIN;
APOPTOSIS; MOUSE
AB The expression of nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) inhibits gastrointestinal tumorigenesis in NAG-1 transgenic mice (C57/BL6 background). In the present study, we investigated whether the NAG-1 protein would alter urethane-induced pulmonary lesions in NAG-1 transgenic mice on an FVB background (NAG-1(Tg+/FVB)). NAG-1Tg+/FVB mice had both decreased number and size of urethane-induced tumors, compared with control littermates (NAG-1(Tg+/FVB) = 16 +/- 4 per mouse versus control = 20 +/- 7 per mouse, P < 0.05). Urethane-induced pulmonary adenomas and adenocarcinomas were observed in control mice; however, only pulmonary adenomas were observed in NAG-1(Tg+/FVB) mice. Urethane-induced tumors from control littermates and NAG-1(Tg+/FVB) mice highly expressed proteins in the arachidonic acid pathway (cyclooxygenases 1/2, prostaglandin E synthase, and prostaglandin E(2) receptor) and highly activated several kinases (phospho-Raf-1 and phosphorylated extracellular signal-regulated kinase 1/2). However, only urethane-induced p38 mitogen-activated protein kinase (MAPK) phosphorylation was decreased in NAG-1(Tg+/FVB) mice. Furthermore, significantly increased apoptosis in tumors of NAG-1(Tg+/FVB) mice compared with control mice was observed as assessed by caspase-3/7 activity. In addition, fewer inflammatory cells were observed in the lung tissue isolated from urethane-treated NAG-1(Tg+/FVB) mice compared with control mice. These results paralleled in vitro assays using human A549 pulmonary carcinoma cells. Less phosphorylated p38 MAPK was observed in cells overexpressing NAG-1 compared with control cells. Overall, our study revealed for the first time that the NAG-1 protein inhibits urethane-induced tumor formation, probably mediated by the p38 MAPK pathway, and is a possible new target for lung cancer chemoprevention.
C1 [Cekanova, Maria; Lee, Seong-Ho; Donnell, Robert L.; Sukhthankar, Mugdha; Baek, Seung Joon] Univ Tennessee, Coll Vet Med, Dept Pathobiol, Knoxville, TN 37996 USA.
[Eling, Thomas E.] Natl Inst Environm Hlth Sci, Mol Carcinogenesis Lab, NIH, Res Triangle Pk, NC USA.
[Fischer, Susan M.] Univ Texas MD Anderson Canc Ctr, Div Sci Pk Res, Dept Carcinogenesis, Smithville, TX USA.
RP Baek, SJ (reprint author), Univ Tennessee, Coll Vet Med, Dept Pathobiol, Knoxville, TN 37996 USA.
EM sbaek2@utk.edu
OI Cekanova, Maria/0000-0002-9651-1619; Donnell, Robert
L./0000-0002-6778-954X
FU American Cancer Society [CNE-111611]; NIH [RO1CA108975]; The University
of Tennessee Center of Excellence in Livestock Diseases and Human
Health; National Institute of Environmental Health Sciences/NIH
FX American Cancer Society grant CNE-111611, NIH grant RO1CA108975, The
University of Tennessee Center of Excellence in Livestock Diseases and
Human Health (S.J. Baek), and National Institute of Environmental Health
Sciences/NIH intramural research program (T. E. Eling).
NR 35
TC 26
Z9 29
U1 0
U2 4
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1940-6207
J9 CANCER PREV RES
JI Cancer Prev. Res.
PD MAY
PY 2009
VL 2
IS 5
BP 450
EP 458
DI 10.1158/1940-6207.CAPR-09-0057
PG 9
WC Oncology
SC Oncology
GA 441IU
UT WOS:000265763300008
PM 19401523
ER
PT J
AU Ross, J
Leavitt, S
AF Ross, Jeffrey
Leavitt, Sharon
TI Mutation spectra induced by conazole fungicides in lacl transgenic
C57BL/6 mouse liver
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Ross, Jeffrey; Leavitt, Sharon] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD MAY 1
PY 2009
VL 69
SU 9
MA 4116
PG 1
WC Oncology
SC Oncology
GA V43ST
UT WOS:000209701800207
ER
PT J
AU Stanko, J
Davis, C
Fenton, S
AF Stanko, Jason
Davis, Christine
Fenton, Suzanne
TI Strain differences in dimethylbenz[a]anthracene-induced mammary tumor
incidence in Long-Evans and Sprague Dawley rat offspring following
prenatal atrazine exposure
SO CANCER RESEARCH
LA English
DT Meeting Abstract
C1 [Stanko, Jason; Davis, Christine; Fenton, Suzanne] US EPA, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD MAY 1
PY 2009
VL 69
SU 9
MA 1220
PG 1
WC Oncology
SC Oncology
GA V43ST
UT WOS:000209701800082
ER
PT J
AU Lye, DJ
AF Lye, Dennis J.
TI A Mouse Model for Characterization of Gastrointestinal Colonization
Rates Among Environmental Aeromonas Isolates
SO CURRENT MICROBIOLOGY
LA English
DT Article
ID RESISTANT ENTEROCOCCUS-FAECIUM; SEROVAR TYPHIMURIUM COLITIS;
PSEUDOMONAS-AERUGINOSA; MURINE MODEL; MICE; STREPTOMYCIN; VIRULENCE;
ANTIBIOTICS; FLAGELLA; DISEASE
AB The colonization rates of 10 different environmental Aeromonas isolates were determined using a novel mouse-streptomycin pretreatment method. As demonstrated, alterations to the colon flora of mice pretreated with streptomycin allowed transient colonization by bacterial species normally excluded by host competition. A novel procedure is described for determining the colonization abilities of Aeromonas isolates under these conditions. The colonization rates of A. salmonicida, A. encheleia, and A. allosaccharophila were either negative or occurred randomly at low levels with respect to concentrations of the dosage consumed by the animals. In contrast, A. hydrophila, A. veronii biovar sobria, and A. caviae exhibited relatively high rates of mouse colon tissue colonization.
C1 US EPA, Natl Exposure Res Lab, Microbial & Chem Exposure Assessment Res Div, Cincinnati, OH 45268 USA.
RP Lye, DJ (reprint author), US EPA, Natl Exposure Res Lab, Microbial & Chem Exposure Assessment Res Div, MS 314,26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM lye.dennis@epa.gov
FU The United States Environmental Protection Agency; Office of Research
and Development
FX The United States Environmental Protection Agency through its Office of
Research and Development funded this research. This study was subjected
to Agency review and approved for publication.
NR 17
TC 3
Z9 3
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0343-8651
J9 CURR MICROBIOL
JI Curr. Microbiol.
PD MAY
PY 2009
VL 58
IS 5
BP 454
EP 458
DI 10.1007/s00284-008-9342-2
PG 5
WC Microbiology
SC Microbiology
GA 430HJ
UT WOS:000264979900009
PM 19130126
ER
PT J
AU Kenneke, JF
Mazur, CS
Sack, TJ
AF Kenneke, John F.
Mazur, Christopher S.
Sack, Thomas J.
TI Mechanistic Investigation of the Stereoselective Carbonyl Reduction of
Triadimefon in Hepatic Microsomes from Human and Seven other Vertebrate
Species
SO DRUG METABOLISM REVIEWS
LA English
DT Meeting Abstract
CT 11th European Regional ISSX Meeting
CY MAY 17-20, 2009
CL Lisbon, PORTUGAL
C1 [Kenneke, John F.; Mazur, Christopher S.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecosyst Res Div, Athens, GA USA.
[Sack, Thomas J.] Senior Serv Amer, US EPA, Athens, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 0360-2532
J9 DRUG METAB REV
JI Drug Metab. Rev.
PD MAY
PY 2009
VL 41
SU 1
MA 160
BP 74
EP 74
PG 1
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 628ZW
UT WOS:000280164800147
ER
PT J
AU Ringold, PL
Van Sickle, J
Bollman, M
Welty, J
Barker, J
AF Ringold, Paul L.
Van Sickle, John
Bollman, Mike
Welty, Jeff
Barker, Jerry
TI Riparian forest indicators of potential future stream condition
SO ECOLOGICAL INDICATORS
LA English
DT Article
DE Riparian forest indicator; Stream wood; Stream assessment; Coarse woody
debris; Anticipatory indicator
ID LARGE WOODY DEBRIS; OREGON COAST RANGE; WESTERN OREGON; QUEETS RIVER;
OLD-GROWTH; RECRUITMENT; USA; WASHINGTON; DYNAMICS; PATTERNS
AB Large wood in streams can play an extraordinarily important role in influencing the physical structure of streams and in providing habitat for aquatic organisms. Since wood is continually lost from streams, predicting the future input of wood to streams from riparian forests is crucial to assessing or managing stream ecosystems. Unfortunately, regional monitoring protocols have no established capacity to provide this information. The goal of this research is to propose one or more methods that could meet this need. This goal is pursued by using stream wood delivery models to aid in the design of a monitoring method. Two questions are asked. First, does simpler data change model predictions of future contributions of wood from riparian ecosystems to the stream? The answers to this first question enable monitoring design to be tailored to details affecting estimates of future stream condition. These answers are important, because more detailed data is typically more costly. Second, which metrics, if any, correlate well with model predictions? If such metrics can be identified, then these measures can serve as effective indicators of ecosystem function directly, without using ecosystem models.
These questions were addressed by collecting highly detailed field observations of riparian forests from 109 forested riparian sites in the Coast Range, Willamette Valley, and western Cascades of northwestern Oregon. Detailed and simplified versions of these data were used in models that forecast the potential of riparian forests to provide wood to the stream. Model predictions with less detailed data typically provided answers different than did predictions made with more detailed data. Thus, ecosystem assessments requiring these types of model predictions would benefit from more detailed data. in contrast, riparian metrics easily observed in the field (e.g. number of basal area of trees) or derived from remotely sensed imagery (e.g. number or height of canopy trees) were well correlated with model predictions of potential stream wood recruitment. When direct model predictions or model scenario analyses are not required, these metrics can serve as effective indicators of the potential of riparian forests to provide wood to the future stream network. Published by Elsevier Ltd.
C1 [Ringold, Paul L.; Van Sickle, John] US EPA, Off Res & Dev, Western Ecol Div, Corvallis, OR 97330 USA.
[Bollman, Mike; Barker, Jerry] Dynamac Corp, Corvallis, OR 97330 USA.
[Welty, Jeff] Weyerhaeuser Co, Federal Way, WA 98063 USA.
RP Ringold, PL (reprint author), US EPA, Off Res & Dev, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97330 USA.
EM ringold.paul@epa.gov; vansickle.john@epa.gov; bollman.mike@epa.gov;
weltyj@wdni.com; jbarker@walshenv.com
NR 64
TC 1
Z9 1
U1 2
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1470-160X
J9 ECOL INDIC
JI Ecol. Indic.
PD MAY
PY 2009
VL 9
IS 3
BP 462
EP 475
DI 10.1016/j.ecolind.2008.06.009
PG 14
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 396CD
UT WOS:000262568900007
ER
PT J
AU Hays, MD
Beck, L
Barfield, P
Willis, RD
Landis, MS
Stevens, RK
AF Hays, Michael D.
Beck, Lee
Barfield, Pamela
Willis, Robert D.
Landis, Matthew S.
Stevens, Robert K.
TI Physical and Chemical Characterization of Residual Oil-Fired Power Plant
Emissions
SO ENERGY & FUELS
LA English
DT Article
ID FINE-PARTICLE EMISSIONS; AIRBORNE PARTICULATE MATTER; SECONDARY ORGANIC
AEROSOL; FUEL-OIL; FLY-ASH; SIZE DISTRIBUTIONS; SULFUR SPECIATION;
COMBUSTION; NICKEL; BOILER
AB Although the toxicity of oil combustion emissions is a significant public health concern, few studies characterize the emissions from plant-scale utility boilers firing residual oil. This study remedies that deficiency by diluting, sampling, and monitoring stack emissions from a 432 gigajoules (GJ) front-fired fossil fuel steam generator burning residual oil. Over a 3-day test period, continuous CO(2), SO(2), and NO(x) emissions monitoring confirms a steady fuel feed rate, high combustion efficiency (3.4 kg of CO(2)/kg of fuel oil burned), and evidence of a nocturnal soot-blowing event. The utility boiler emits fine aerosol (PM(2.5)) at a rate of 53 +/- 2 ug/kJ (2 g/kg of oil burned). Vesicular coarse particles composed of C and S and spherical Al silicates with V and Ni inclusions are identified in a cyclone rinse using scanning electron microscopy and backscatter analysis. Ion chromatography results establish that the fine aerosol is predominantly sulfate (44% +/- 0.2%, w/w) which is likely coordinated to transition metals. From thermal optical transmittance measurements, less than 1% (w/w) of the fine aerosol is surmised to be carbonaceous. Low emissions of particle-phase carbon and contaminants interfered with the gas chromatography-mass spectrometry (GC-MS) analysis of polcyclic aromatic hydrocarbons and certain other semivolatile organic compounds. However, trace levels of branched-, cyclic-, and n-alkanes and organic acids are observed in the particle emissions. Sterane and hopane molecules are below the picogram level GC-MS detection limits. Future research determining the individual organic species in the particles emitted from this source will require real-time single particle measurements. Finally, application of EPA methods TO-11 and TO-15 shows that the total volatile nonmethane organic gas emissions from the plant-scale boiler vary between 6 and 28 mg/kg of fuel oil burned; greater than 50% of this mass is ascribed to oxygenated matter.
C1 [Hays, Michael D.; Beck, Lee; Barfield, Pamela; Willis, Robert D.; Landis, Matthew S.; Stevens, Robert K.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Hays, MD (reprint author), US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
EM hays.michael@epa.gov
RI Hays, Michael/E-6801-2013; Landis, Matthew/P-5149-2014
OI Hays, Michael/0000-0002-4029-8660; Landis, Matthew/0000-0002-8742-496X
NR 52
TC 11
Z9 11
U1 1
U2 21
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0887-0624
J9 ENERG FUEL
JI Energy Fuels
PD MAY-JUN
PY 2009
VL 23
BP 2544
EP 2551
DI 10.1021/ef8011118
PG 8
WC Energy & Fuels; Engineering, Chemical
SC Energy & Fuels; Engineering
GA 463FX
UT WOS:000267416600028
ER
PT J
AU Yang, YJ
Goodrich, JA
AF Yang, Y. Jeffrey
Goodrich, James A.
TI Timing and prediction of climate change and hydrological impacts:
periodicity in natural variations
SO ENVIRONMENTAL GEOLOGY
LA English
DT Article
DE Climate change; Hydrologic periodicity; Precipitation variations;
Wavelet analysis; Water resource management
ID EOCENE THERMAL MAXIMUM; PHANEROZOIC SEAWATER; FREQUENCY-ANALYSIS; LATE
PLEISTOCENE; ATMOSPHERIC CO2; GLACIAL CYCLES; ANTARCTIC ICE;
CARBON-CYCLE; VARIABILITY; PRECIPITATION
AB Hydrological impacts from climate change are of principal interest to water resource policy-makers and practicing engineers. Predictive climatic models have been extensively investigated to quantify the impacts. Palaeoclmatic investigations, on the other hand, show unequivocal and strong periodicity of climate variations in proxy evidence. Yet how to use the periodicity in future hydroclimatic timing and forecasting has received less attention. This paper examines the periodicity in Pleistocene-Holocene glacial-interglacial events and in modern precipitation records, and discusses a way in which the periodicity is used for hydroclimatic predictions. The analysis, based on published CO2, Delta T (delta H-2) and delta O-18 proxy data of polar ice cores and deep oceanic benthic fossils, shows a periodicity in a similar to similar to 100, similar to 40 or 25 kyear duration consistent with Milankovitch orbital regulations during the glacial-interglacial periods. On a fine time scale, millennium and multi-decadal periodicity is observed in high-resolution proxy variations of Greenland ice cores and in instrumental precipitation records of the contiguous USA. A basic periodicity of decadal and multi-decadal changes in similar to 20 and similar to 10-15 year duration is apparent in wavelet frequency analysis of both ice core proxy and precipitation data. While the kyear-scale periodicity is found of global prevalence, the millennium and decadal variations vary in space and are region-specific. Based on these findings, a generalized time-downscaling hierarchy of periodicity is proposed as a potential approach for timing and forecasting future hydroclimatic conditions at a resolution relevant to the water resources engineering and management.
C1 [Yang, Y. Jeffrey; Goodrich, James A.] US EPA, Water Supply & Water Resources Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Yang, YJ (reprint author), US EPA, Water Supply & Water Resources Div, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM yang.jeff@epa.gov
NR 59
TC 2
Z9 2
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0943-0105
J9 ENVIRON GEOL
JI Environ. Geol.
PD MAY
PY 2009
VL 57
IS 5
BP 1065
EP 1078
DI 10.1007/s00254-008-1392-z
PG 14
WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources
SC Environmental Sciences & Ecology; Geology; Water Resources
GA 436UC
UT WOS:000265440600011
ER
PT J
AU Judson, R
Richard, A
Dix, DJ
Houck, K
Martin, M
Kavlock, R
Dellarco, V
Henry, T
Holderman, T
Sayre, P
Tan, S
Carpenter, T
Smith, E
AF Judson, Richard
Richard, Ann
Dix, David J.
Houck, Keith
Martin, Matthew
Kavlock, Robert
Dellarco, Vicki
Henry, Tala
Holderman, Todd
Sayre, Philip
Tan, Shirlee
Carpenter, Thomas
Smith, Edwin
TI The Toxicity Data Landscape for Environmental Chemicals
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
DE ACToR; carcinogenicity; database; developmental; hazard; HPV; MPV;
pesticide; reproductive; toxicity
ID IN-SILICO PHARMACOLOGY; WEB RESOURCES; TOXICOLOGY INFORMATION;
PARTITION-COEFFICIENT; DRUG DISCOVERY; METABOLISM; PROTECTION; INTERNET;
HUMANS; WORLD
AB OBJECTIVE: Thousands of chemicals are in common use, but only a portion of them have undergone significant toxicologic evaluation, leading to the need to prioritize the remainder for targeted testing. To address this issue, the U.S. Environmental Protection Agency (EPA) and other organizations are developing chemical screening and prioritization programs. As part of these efforts, it is important to catalog, from widely dispersed sources, the toxicology information that is available. The main objective of this analysis is to define a list of environmental chemicals that are candidates for the U.S. EPA screening and prioritization process, and to catalog the available toxicology information.
DATA SOURCES: We are developing ACToR (Aggregated Computational Toxicology Resource), which combines information for hundreds of thousands of chemicals from > 200 public sources, including the U.S. EPA, National Institutes of Health, Food and Drug Administration, corresponding agencies in Canada, Europe, and Japan, and academic sources.
DATA EXTRACTION: ACToR contains chemical structure information; physical-chemical properties; in vitro assay data; tabular in vivo data; summary toxicology calls (e.g., a statement that a chemical is considered to be a human carcinogen); and links to online toxicology summaries. Here, we use data from ACToR to assess the toxicity data landscape for environmental chemicals.
DATA SYNTHESIS: We show results for a set of 9,912 environmental chemicals being considered for analysis as part of the U.S. EPA ToxCast screening and prioritization program. These include high- and medium-production-volume chemicals, pesticide active and inert ingredients, and drinking water contaminants.
CONCLUSIONS: Approximately two-thirds of these chemicals have at least limited toxicity summaries available. About one-quarter have been assessed in at least one highly curated toxicology evaluation database such as the U.S. EPA Toxicology Reference Database, U.S. EPA Integrated Risk Information System, and the National Toxicology Program.
C1 [Judson, Richard; Richard, Ann; Dix, David J.; Houck, Keith; Martin, Matthew; Kavlock, Robert] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Dellarco, Vicki] US EPA, Off Pesticide Programs, Off Prevent Pesticides & Tox Subst, Arlington, VA USA.
[Henry, Tala; Holderman, Todd; Sayre, Philip] US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA.
[Tan, Shirlee] US EPA, Off Sci Coordinat & Policy, Off Prevent Pesticides & Tox Subst, Washington, DC 20460 USA.
[Carpenter, Thomas] US EPA, Off Water, Off Ground Water & Drinking Water, Washington, DC 20460 USA.
[Smith, Edwin] US EPA, Great Lakes Natl Program Off, Chicago, IL USA.
RP Judson, R (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
OI Judson, Richard/0000-0002-2348-9633
NR 86
TC 165
Z9 170
U1 14
U2 76
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAY
PY 2009
VL 117
IS 5
BP 685
EP 695
DI 10.1289/ehp.0800168
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 440SZ
UT WOS:000265721300018
PM 19479008
ER
PT J
AU Cooper, GS
Makris, SL
Nietert, PJ
Jinot, J
AF Cooper, Glinda S.
Makris, Susan L.
Nietert, Paul J.
Jinot, Jennifer
TI Evidence of Autoimmune-Related Effects of Trichloroethylene Exposure
from Studies in Mice and Humans
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
DE autoimmune liver disease; solvents; systemic sclerosis;
trichloroethylene
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; OCCUPATIONAL RISK-FACTORS;
T-CELL-ACTIVATION; ALDEHYDE-PROTEIN ADDUCTS; MEDIATED IMMUNE STATUS; PIG
MAXIMIZATION TEST; BROWN-NORWAY RAT; MRL+/+ MICE; RHEUMATOID-ARTHRITIS;
LIPID-PEROXIDATION
AB OBJECTIVE: Our objective was to examine experimental and epidemiologic studies pertaining to immune-related, and specifically autoimmune-related, effects of trichloroethylene (TCE).
DATA SOURCES AND EXTRACTION: We performed a literature search of PubMed and reviewed bibliographies in identified articles. We then systematically reviewed immune-related data, focusing on clinical and immunologic features and mechanistic studies.
DATA SYNTHESIS: Studies conducted in MRL(+/+) lupus mice report an accelerated autoimmune response in relation to exposure to TCE or some metabolites. Effects have been reported after 4 weeks of exposure to TCE at doses as low as 0.1 mg/kg/day in drinking water and have included increased antinuclear antibodies and interferon-gamma (IFN-gamma) and decreased secretion of interleukin-4 (IL-4), consistent with an inflammatory response. Autoimmune hepatitis, inflammatory skin lesions, and alopecia have been found after exposures of 32-48 weeks. Recent mechanistic experiments in mice examined oxidative stress and, specifically, effects on lipid-peroxidation-derived aldehydes in TCE-induced autoimmune disease. Two studies in humans reported an increase in IL-2 or IFN-gamma and a decrease in IL-4 in relation to occupational or environmental TCE exposure. Occupational exposure to TCE has also been associated with a severe, generalized hypersensitivity skin disorder accompanied by systemic effects, including hepatitis. In three case-control studies of scleroderma with a measure of occupational TCE exposure, the combined odds ratio was 2.5 [95% confidence interval (CI), 1.1-5.4] in men and 1.2 (95% CI, 0.58-2.6) in women.
CONCLUSION: The consistency among the studies and the concordance between the studies in mice and humans support an etiologic role of TCE in autoimmune disease. Multisite collaborations and studies of preclinical immune markers are needed to further develop this field of research.
C1 [Cooper, Glinda S.; Makris, Susan L.; Jinot, Jennifer] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
[Nietert, Paul J.] Med Univ S Carolina, Charleston, SC 29425 USA.
RP Cooper, GS (reprint author), US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
OI Nietert, Paul/0000-0002-3933-4986
NR 65
TC 48
Z9 52
U1 2
U2 12
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAY
PY 2009
VL 117
IS 5
BP 696
EP 702
DI 10.1289/ehp.11782
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 440SZ
UT WOS:000265721300019
PM 19479009
ER
PT J
AU Farraj, AK
Haykal-Coates, N
Winsett, DW
Hazari, MS
Carli, AA
Rowan, WH
Ledbetter, AD
Cascio, WE
Costa, DL
AF Farraj, Aimen K.
Haykal-Coates, Najwa
Winsett, Darrell W.
Hazari, Mehdi S.
Carli, Alex A.
Rowan, William H., III
Ledbetter, Allen D.
Cascio, Wayne E.
Costa, Daniel L.
TI Increased Nonconducted P-Wave Arrhythmias after a Single Oil Fly Ash
Inhalation Exposure in Hypertensive Rats
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE arrhythmia; electrocardiogram; heart rate variability; hypertension;
inhalation; nonconducted P-waves; particulate matter; rats; residual oil
fly ash
ID PARTICULATE AIR-POLLUTION; HEART-RATE-VARIABILITY;
CORONARY-ARTERY-DISEASE; ST-SEGMENT DEPRESSION; MYOCARDIAL-INFARCTION;
FINE PARTICULATE; AMBIENT AIR; ULTRAFINE PARTICLES; CARDIAC-ARRHYTHMIA;
TRANSITION-METALS
AB BACKGROUND: Exposure to combustion-derived fine particulate matter (PM) is associated with increased cardiovascular morbidity and mortality especially in individuals with cardiovascular disease, including hypertension. PM inhalation causes several adverse changes in cardiac function that are reflected in the electrocardiogram (ECG), including altered cardiac rhythm, myocardial ischemia, and reduced heart rate variability (HRV). The sensitivity and reliability of ECG-derived parameters as indicators of the cardiovascular toxicity of PM in rats are unclear.
OBJECTIVE: We hypothesized that spontaneously hypertensive (SH) rats are more susceptible to the development of PM-induced arrhythmia, altered ECG morphology, and reduced HRV than are Wistar Kyoto (WKY) rats, a related strain with normal blood pressure.
METHODS: We exposed rats once by nose-only inhalation for 4 hr to residual oil fly ash (ROFA), an emission source particle rich in transition metals, or to air and then sacrificed them 1 or 48 hr later.
RESULTS: ROFA-exposed SH rats developed nonconducted P-wave arrhythmias but no changes in ECG morphology or HRV. We found no ECG effects in ROFA-exposed WKY rats. ROFA-exposed SH rats also had greater pulmonary injury, neutrophil infiltration, and serum C-reactive protein than did ROFA-exposed WKY rats.
CONCLUSIONS: These results suggest that cardiac arrhythmias may be an early sensitive indicator of the propensity for PM inhalation to modify cardiovascular function.
C1 [Farraj, Aimen K.; Haykal-Coates, Najwa; Winsett, Darrell W.; Hazari, Mehdi S.; Ledbetter, Allen D.] US EPA, Expt Toxicol Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Carli, Alex A.] Univ N Carolina, Chapel Hill, NC USA.
[Rowan, William H., III] ITT Corp, Adv Engn & Sci, Alexandria, VA USA.
[Cascio, Wayne E.] E Carolina Univ, Brody Sch Med, Greenville, NC USA.
[Costa, Daniel L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Farraj, AK (reprint author), US EPA, Expt Toxicol Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
OI Carll, Alex/0000-0003-1832-3070
NR 54
TC 26
Z9 27
U1 1
U2 3
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAY
PY 2009
VL 117
IS 5
BP 709
EP 715
DI 10.1289/ehp.0800129
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 440SZ
UT WOS:000265721300021
PM 19479011
ER
PT J
AU Stout, MD
Herbert, RA
Kissling, GE
Collins, BJ
Travlos, GS
Witt, KL
Melnick, RL
Abdo, KM
Malarkey, DE
Hooth, MJ
AF Stout, Matthew D.
Herbert, Ronald A.
Kissling, Grace E.
Collins, Bradley J.
Travlos, Gregory S.
Witt, Kristine L.
Melnick, Ronald L.
Abdo, Karnal M.
Malarkey, David E.
Hooth, Michelle J.
TI Hexavalent Chromium Is Carcinogenic to F344/N Rats and B6C3F1 Mice after
Chronic Oral Exposure
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE anemia; cancer; hexavalent chromium; histiocytic cellular infiltration;
National Toxicology Program; oral cavity; small intestine
ID DRINKING-WATER; DNA ADDUCTS; DOSE LEVELS; TOXICITY; MUTAGENICITY;
ABSORPTION; MECHANISMS; INGESTION; MORTALITY; ASCORBATE
AB BACKGROUND: Hexavalent chromium [Cr(VI)] is a human carcinogen after inhalation exposure. Humans also ingest Cr(VI) from contaminated drinking water and soil; however, limited data exist on the oral toxicity and carcinogenicity of Cr(VI).
OBJECTIVE: We characterized the chronic oral toxicity and carcinogenicity of Cr(VI) in rodents.
METHODS: The National Toxicology Program (NTP) conducted 2-year drinking water studies of Cr(VI) (as sodium dichromate dihydrate) in male and female F344/N rats and B6C3F1 mice.
RESULTS: Cr(VI) exposure resulted in increased incidences of rare neoplasms of the squamous epithelium that lines the oral cavity (oral mucosa and tongue) in male and female rats, and of the epithelium lining the small intestine in male and female mice. Cr(VI) exposure did not affect survival but resulted in reduced mean body weights and water consumption, due at least in part to poor palatability of the dosed water. Cr(VI) exposure resulted in transient microcytic hypochromic anemia in rats and microcytosis in mice. Nonneoplastic lesions included diffuse epithelial hyperplasia in the duodenum and jejunum of mice and histiocytic cell infiltration in the duodenum, liver, and mesenteric and pancreatic lymph nodes of rats and mice.
CONCLUSIONS: Cr(VI) was carcinogenic after administration in drinking water to male and female rats and mice.
C1 [Stout, Matthew D.; Herbert, Ronald A.; Kissling, Grace E.; Collins, Bradley J.; Travlos, Gregory S.; Witt, Kristine L.; Melnick, Ronald L.; Abdo, Karnal M.; Malarkey, David E.; Hooth, Michelle J.] Natl Inst Environm Hlth Sci, Natl Toxicol Program, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
RP Stout, MD (reprint author), Natl Inst Environm Hlth Sci, Natl Toxicol Program, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
FU FDA HHS [1 Z01 ES045004-11 BB]; Intramural NIH HHS; NIEHS NIH HHS [Z01
ES045004]
NR 51
TC 78
Z9 86
U1 1
U2 14
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAY
PY 2009
VL 117
IS 5
BP 716
EP 722
DI 10.1289/ehp.0800208
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 440SZ
UT WOS:000265721300022
PM 19479012
ER
PT J
AU Thorne, PS
Cohn, RD
Mav, D
Arbes, SJ
Zeldin, DC
AF Thorne, Peter S.
Cohn, Richard D.
Mav, Deepak
Arbes, Samuel J., Jr.
Zeldin, Darryl C.
TI Predictors of Endotoxin Levels in US Housing
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE allergens; asthma triggers; endotoxin; house dust; housing
characteristics; indoor air; lipopolysaccharide;
microorganism-associated molecular pattern; predictive model; reservoir
dust
ID 1ST NATIONAL-SURVEY; ALTERNARIA-ALTERNATA; DUST ENDOTOXIN; EXPOSURE
RISK; GERMAN HOMES; BIRTH COHORT; ALLERGENS; ASTHMA; LEAD; PREVALENCE
AB The relationship of domestic endotoxin exposure to allergy and asthma has been widely investigated. However, few studies have evaluated predictors of household endotoxin, and none have done so for multiple locations within homes and on a national scale.
OBJECTIVES: We assayed 2,552 house dust samples in a nationwide study to understand the predictors of household endotoxin in bedroom floors, family room floors, beds, kitchen floors, and family room sofas.
METHODS: Reservoir house dust from five locations within homes was assayed for endotoxin and demographic and housing information was assessed through questionnaire and onsite evaluation of 2,456 residents of 831 homes selected to represent national demographics. We performed repeated-measures analysis of variance (rANOVA) for 37 candidate variables to identify independent predictors of endotoxin. Meteorologic data were obtained for each primary sampling unit and tested as predictors of indoor endotoxin to determine if wetter or warmer microclimates were associated with higher endotoxin levels.
RESULTS: Weighted geometric mean endotoxin concentration ranged from 18.7 to 80.5 endotoxin units (EU)/mg for the five sampling locations, and endotoxin load ranged from 4,160 to 19,500 EU/m(2). Bivariate analyses and rANOVA demonstrated that major predictors of endotoxin concentration were sampling location in the home, census division, educational attainment, presence of children, current dog ownership, resident-described problems with cockroaches, food debris, cockroach stains, and evidence of smoking observed by field staff. Low household income entered the model if educational attainment was removed.
CONCLUSION: Increased endotoxin in household reservoir dust is principally associated with poverty, people, pets, household cleanliness, and geography.
C1 [Thorne, Peter S.] Univ Iowa, Coll Publ Hlth, Dept Occupat & Environm Hlth, Environm Hlth Sci Res Ctr, Iowa City, IA 52242 USA.
[Cohn, Richard D.; Mav, Deepak] Constella Grp LLC, Durham, NC USA.
[Arbes, Samuel J., Jr.; Zeldin, Darryl C.] Natl Inst Environm Hlth Sci, Div Intramural Res, Res Triangle Pk, NC USA.
RP Thorne, PS (reprint author), Univ Iowa, Coll Publ Hlth, Dept Occupat & Environm Hlth, Environm Hlth Sci Res Ctr, 100 Oakdale Campus,176 IREH, Iowa City, IA 52242 USA.
EM peter-thorne@uiowa.edu
FU National Institute of Environmental Health Sciences (NIEHS) [P30
ES05605]; U.S. Department of Housing and Urban Development's Office of
Healthy Homes and Lead Hazard Control; Intramural Research Program of
the NIEHS, National Institutes of Health
FX This work was supported by National Institute of Environmental Health
Sciences (NIEHS) grant P30 ES05605, U.S. Department of Housing and Urban
Development's Office of Healthy Homes and Lead Hazard Control, and the
Intramural Research Program of the NIEHS, National Institutes of Health.
NR 23
TC 61
Z9 61
U1 0
U2 6
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAY
PY 2009
VL 117
IS 5
BP 763
EP 771
DI 10.1289/ehp.11759
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 440SZ
UT WOS:000265721300029
PM 19479019
ER
PT J
AU Angradi, TR
Bolgrien, DW
Jicha, TM
Pearson, MS
Hill, BH
Taylor, DL
Schweiger, EW
Shepard, L
Batterman, AR
Moffett, MF
Elonen, CM
Anderson, LE
AF Angradi, T. R.
Bolgrien, D. W.
Jicha, T. M.
Pearson, M. S.
Hill, B. H.
Taylor, D. L.
Schweiger, E. W.
Shepard, L.
Batterman, A. R.
Moffett, M. F.
Elonen, C. M.
Anderson, L. E.
TI A bioassessment approach for mid-continent great rivers: the Upper
Mississippi, Missouri, and Ohio (USA)
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Bioassessment; EMAP; Great rivers; Indicator; Least disturbed condition;
Missouri River; Ohio River; Reference condition; Stressors; Upper
Mississippi River
ID MULTIMETRIC INDEX; NORTH-DAKOTA; ECOSYSTEMS; MANAGEMENT; INTEGRITY;
STREAMS; BENTHOS
AB The objectives of the Environmental Monitoring and Assessment Program for Great River Ecosystems (EMAP-GRE) are to (1) develop and demonstrate, in collaboration with states, an assessment program yielding spatially unbiased estimates of the condition of mid-continent great rivers; (2) evaluate environmental indicators for assessing great rivers; and (3) assess the current condition of selected great river resources. The purpose of this paper is to describe EMAP-GRE using examples based on data collected in 2004-2006 with emphasis on an approach to determining reference conditions. EMAP-GRE includes the Upper Mississippi River, the Missouri River, and the Ohio River. Indicators include biotic assemblages (fish, macroinvertebrates, plankton, algae), water chemistry, and aquatic and riparian physical habitat. Reference strata (river reaches for which a single reference expectation is appropriate) were determined by ordination of the fish assemblage and examination of spatial variation in environmental variables. Least disturbed condition of fish assemblages for reference strata was determined by empirical modeling in which we related fish assemblage metrics to a multimetric stressor gradient. We inferred least disturbed condition from the y-intercept, the predicted condition when stress was least. Thresholds for dividing the resource into management-relevant condition classes for biotic indicators were derived using predicted least disturbed condition to set the upper bound on the least disturbed condition class. Also discussed are the outputs of EMAP-GRE, including the assessment document, multimetric indices of condition, and unbiased data supporting state and tribal Clean Water Act reporting, adaptive management, and river restoration.
C1 [Angradi, T. R.; Bolgrien, D. W.; Jicha, T. M.; Pearson, M. S.; Hill, B. H.; Taylor, D. L.; Batterman, A. R.; Moffett, M. F.; Elonen, C. M.; Anderson, L. E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA.
[Schweiger, E. W.] Natl Pk Serv, Ft Collins, CO 80525 USA.
[Shepard, L.] US EPA, Kansas City, MO USA.
RP Angradi, TR (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM angradi.theodore@epa.gov
RI Hill, Brian/E-6799-2013
NR 55
TC 22
Z9 26
U1 3
U2 27
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD MAY
PY 2009
VL 152
IS 1-4
BP 425
EP 442
DI 10.1007/s10661-008-0327-1
PG 18
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 425EX
UT WOS:000264620900037
PM 18483771
ER
PT J
AU Axelrad, DA
Goodman, S
Woodruff, TJ
AF Axelrad, Daniel A.
Goodman, Stephanie
Woodruff, Tracey J.
TI PCB body burdens in US women of childbearing age 2001-2002: An
evaluation of alternate summary metrics of NHANES data
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE PCBs; Biomonitoring; Body burdens; NHANES; Neurodevelopment
ID POLYCHLORINATED BIPHENYL CONCENTRATIONS; PRESCHOOL INUIT CHILDREN;
ASSESSMENT SCALE NBAS; PRENATAL EXPOSURE; ENVIRONMENTAL EXPOSURE;
DICHLORODIPHENYL DICHLOROETHENE; RESPONSE-INHIBITION; SCHOOL-AGE;
IN-UTERO; NEUROPSYCHOLOGICAL FUNCTION
AB An extensive body of epidemiologic data associates prenatal exposure to polychlorinated biphenyls (PCBs) with neurodevelopmental deficits and other childhood health effects. Neurological effects and other adverse health effects may also result from exposure during infancy, childhood, and adulthood. Although manufacture and use of PCBs were banned in the US in 1977, exposure to PCBs is a continuing concern due to the widespread distribution of these compounds in the environment and their persistence. The National Health and Nutrition Examination Survey provides PCB body burden measurements representative of the US population for the years 1999-2002. Interpretation of these data is challenging due to the large number of PCB congeners reported. We examined 6 PCB body burden metrics to identify an approach for summarizing the NHANES data and for characterizing changes over time in potential risks to children's health. We focused on women of childbearing age, defined here as 16-39 years, because in utero exposures have been associated with neurodevelopmental effects, and used only the 2001-2002 data because of higher detection rates. The 6 metrics, each consisting of different combinations of the 9 most frequently detected congeners, were as follows: total PCBs (all 9 congeners): highly chlorinated PCBs (2 congeners): dioxin-like PCBs (3 congeners, weighted by toxic equivalency factors); non-dioxin-like PCBs (6 congeners); a 4-congener metric (PCBs 118,138, 153, and 180); and PCB-153 alone. The PCB metrics were generally highly correlated with each other. There was a strong association of PCB body burdens with age for all metrics. Median body burdens of Mexican American women were lower than those of non-Hispanic White and non-Hispanic Black women for 5 of the 6 metrics, and there were no significant differences in body burdens between the latter two groups. Body burdens of women with incomes above poverty level were greater than those for lower-income women at the median and 95th percentiles, but the differences were not statistically significant for any metric. We conclude that the 4-congener and total PCBs metrics are the most promising approaches for tracking changes in body burdens over time and for comparing body burdens of different subgroups in NHANES. Published by Elsevier Inc.
C1 [Axelrad, Daniel A.] US EPA, Off Policy Econ & Innovat, Washington, DC 20460 USA.
[Woodruff, Tracey J.] Univ Calif San Francisco, Program Reprod Hlth & Environm, San Francisco, CA 94143 USA.
RP Axelrad, DA (reprint author), US EPA, Off Policy Econ & Innovat, 1200 Penn Ave NW 1809T, Washington, DC 20460 USA.
EM axelrad.daniel@epa.gov
NR 65
TC 27
Z9 27
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
J9 ENVIRON RES
JI Environ. Res.
PD MAY
PY 2009
VL 109
IS 4
BP 368
EP 378
DI 10.1016/j.envres.2009.01.003
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 443GH
UT WOS:000265897700002
PM 19251256
ER
PT J
AU Gale, RW
Cranor, WL
Alvarez, DA
Huckins, JN
Petty, JD
Robertson, GL
AF Gale, Robert W.
Cranor, Walter L.
Alvarez, David A.
Huckins, James N.
Petty, Jimmie D.
Robertson, Gary L.
TI Semivolatile Organic Compounds in Residential Air along the
Arizona-Mexico Border
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID SEMIPERMEABLE-MEMBRANE DEVICES; POLYBROMINATED DIPHENYL ETHERS;
RIO-GRANDE VALLEY; INDOOR-AIR; ORGANOCHLORINE PESTICIDES; OUTDOOR AIR;
PASSIVE SAMPLERS; FLAME RETARDANTS; SPMDS; CONTAMINANTS
AB Concerns about indoor air quality and the potential effects on people living in these environments are increasing as more reports about the toxicities and the potential indoor air exposure levels of household-use chemicals and chemicals from housing and furnishing manufacture in air are being assessed. Gas chromatography/mass spectrometry was used to confirm numerous airborne contaminants obtained from the analysis of semipermeable membrane devices deployed inside of 52 homes situated along the border between Arizona and Mexico. We also describe nontarget analytes in the organochlorine pesticide fractions of 12 of these homes; this fraction is also the most likely to contain the broadest scope of bioconcentratable chemicals accumulated from the indoor air. Approximately 400 individual components were identified, ranging from pesticides to a wide array of hydrocarbons, fragrances such as the musk xylenes, flavors relating to spices, aldehydes, alcohols, esters and phthalate esters, and other miscellaneous types of chemicals. The results presented in this study demonstrate unequivocally that the mixture of airborne chemicals present indoors is far more complex than previously demonstrated.
C1 [Gale, Robert W.; Cranor, Walter L.; Alvarez, David A.; Huckins, James N.; Petty, Jimmie D.] US Geol Survey, Columbia Environm Res Ctr, Columbia, MO 65201 USA.
[Robertson, Gary L.] US EPA, Human Exposure & Atmospher Sci Div, Off Res & Dev, Natl Exposure Res Lab, Las Vegas, NV 89119 USA.
RP Gale, RW (reprint author), US Geol Survey, Columbia Environm Res Ctr, 4200 New Haven Rd, Columbia, MO 65201 USA.
EM rgale@usgs.gov
FU U.S. Environmental Protection Agency [DW14937889-01-0]
FX We acknowledge support by the U.S. Environmental Protection Agency under
interagency agreement DW14937889-01-0. Ally use of trade, product, or
firm names is for descriptive purposes only and does not imply
endorsement by the U.S. Government.
NR 40
TC 5
Z9 5
U1 3
U2 24
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAY 1
PY 2009
VL 43
IS 9
BP 3054
EP 3060
DI 10.1021/es803482u
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 441PL
UT WOS:000265781100017
PM 19534113
ER
PT J
AU Lazorchak, JM
Smith, ME
Haring, HJ
AF Lazorchak, James M.
Smith, Mark E.
Haring, Herman J.
TI DEVELOPMENT AND VALIDATION OF A DAPHNIA MAGNA FOUR-DAY SURVIVAL AND
GROWTH TEST METHOD
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Daphnia magna; Test method; Short-chronic; Growth; Ceriodaphnia dubia
ID BIOTIC LIGAND MODEL; TOXICITY TESTS; CERIODAPHNIA-DUBIA; ZINC TOXICITY;
HUMIC-ACID; BIOAVAILABILITY
AB Zooplankton are an important part of the aquatic ecology of all lakes and streams. As a result, numerous methods have been developed to assess the quality of waterbodies using various zooplankton species. Included in these is the freshwater species Daphnia magna. Current test methods using D. magna involve acute lethality test methods ranging from 24 to 96 h in duration and chronic test methods with durations of 21 to 28 d. Whereas the current acute and chronic test methods are useful, a need exists for a shorter-duration test method that will provide a chronic or subchronic endpoint with this species. In the present study, a 4-d, static-renewal survival and growth test was developed for use with D. magna. The test results were compared to performance criteria and results from 7-d survival and reproduction tests with Ceriodaphnia dubia to determine the level of comparability between the two methods. Results from the 4-d D. magna survival and growth test method indicated that this method will produce consistent results with various reference toxicant materials and provide data that are both reproducible and useful for detecting potential toxicity in aquatic environments.
C1 [Lazorchak, James M.; Smith, Mark E.; Haring, Herman J.] US EPA, Off Res & Dev, Natl Exposure Res Lab, McConnell Grp, Cincinnati, OH 45268 USA.
RP Lazorchak, JM (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, McConnell Grp, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM lazorchak.jim@epa.gov
OI Lazorchak, James/0000-0002-7354-7571
FU U.S. EPA
FX The authors would like to acknowledge the technical support provided in
the development of this method by Lori Herrin, Ann Kneipp, Sandy Brewer,
and John Wirts of DynCorp. Review comments provided by G. Allen Burton
of Wright State University, Debra Denton of the U. S. EPA, and two
anonymous reviewers were most helpful, as was the technical review
provided by Justicia Rhodus (Dynamac). The research reported in this
document was funded by the U.S. EPA.
NR 27
TC 14
Z9 14
U1 1
U2 13
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD MAY
PY 2009
VL 28
IS 5
BP 1028
EP 1034
DI 10.1897/08-296.1
PG 7
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 433RN
UT WOS:000265223600017
PM 19067494
ER
PT J
AU Lewis, DR
Wade, TJ
Lobdell, DT
Neas, LM
AF Lewis, Denise Riedel
Wade, Timothy J.
Lobdell, Danelle T.
Neas, Lucas M.
TI Rebecca Lea Calderon, 1955-2008
SO EPIDEMIOLOGY
LA English
DT Biographical-Item
C1 [Lewis, Denise Riedel] NCI, Surveillance Res Program, Bethesda, MD 20892 USA.
[Wade, Timothy J.; Lobdell, Danelle T.; Neas, Lucas M.] US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
RP Lewis, DR (reprint author), NCI, Surveillance Res Program, 6116 Execut Blvd,Suite 504, Bethesda, MD 20892 USA.
EM lewisde@mail.nih.gov
NR 1
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
J9 EPIDEMIOLOGY
JI Epidemiology
PD MAY
PY 2009
VL 20
IS 3
BP 461
EP 461
DI 10.1097/EDE.0b013e31819f2de9
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 433JJ
UT WOS:000265199800025
ER
PT J
AU Ellefsen, KJ
Croize, D
Mazzella, AT
McKenna, JR
AF Ellefsen, Karl J.
Croize, Delphine
Mazzella, Aldo T.
McKenna, Jason R.
TI Frequency-domain Green's functions for radar waves in heterogeneous 2.5D
media
SO GEOPHYSICS
LA English
DT Article
ID ELECTROMAGNETIC INDUCTION; BOREHOLE; INVERSION; FDFD
AB Green's functions for radar waves propagating in heterogeneous 2.5D media might be calculated in the frequency domain using a hybrid method. The model is defined in the Cartesian coordinate system, and its electromagnetic properties might vary in the x- and z-directions, but not in the y-direction. Wave propagation in the x- and z-directions is simulated with the finite-difference method, and wave propagation in the y-direction is simulated with an analytic function. The absorbing boundaries on the finite-difference grid are perfectly matched layers that have been modified to make them compatible with the hybrid method. The accuracy of these numerical Green's functions is assessed by comparing them with independently calculated Green's functions. For a homogeneous model, the magnitude errors range from -4.16% through 0.44%, and the phase errors range from -0.06% through 4.86%. For a layered model, the magnitude errors range from -2.60% through 2.06%, and the phase errors range from -0.49% through 2.73%. These numerical Green's functions might be used for forward modeling and full waveform inversion.
C1 [Ellefsen, Karl J.] US Geol Survey, Denver, CO 80225 USA.
[Croize, Delphine] Univ Oslo, Oslo, Norway.
[Mazzella, Aldo T.] US EPA, Las Vegas, NV 89193 USA.
[McKenna, Jason R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA.
RP Ellefsen, KJ (reprint author), US Geol Survey, Box 25046, Denver, CO 80225 USA.
EM ellefsen@usgs.gov; delphine.croize@geo.uio.no; mazzella.aldo@epa.gov;
Jason.R.McKenna@usace.army.mil
NR 32
TC 2
Z9 2
U1 0
U2 2
PU SOC EXPLORATION GEOPHYSICISTS
PI TULSA
PA 8801 S YALE ST, TULSA, OK 74137 USA
SN 0016-8033
J9 GEOPHYSICS
JI Geophysics
PD MAY-JUN
PY 2009
VL 74
IS 3
BP J13
EP J22
DI 10.1190/1.3092776
PG 10
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA 443BI
UT WOS:000265884800017
ER
PT J
AU Del Grosso, SJ
Ojima, DS
Parton, WJ
Stehfest, E
Heistermann, M
DeAngelo, B
Rose, S
AF Del Grosso, Stephen J.
Ojima, Dennis S.
Parton, William J.
Stehfest, Elke
Heistermann, Maik
DeAngelo, Benjamin
Rose, Steven
TI Global scale DAYCENT model analysis of greenhouse gas emissions and
mitigation strategies for cropped soils
SO GLOBAL AND PLANETARY CHANGE
LA English
DT Article; Proceedings Paper
CT Fall Annual Meeting of the American-Geophysical-Union
CY 2005
CL San Francisco, CA
SP Amer Geophys Union
DE global change; greenhouse gas mitigation; ecosystem modeling;
agriculture
ID CARBON SEQUESTRATION; ECOSYSTEM MODEL; ORGANIC-MATTER; CLIMATE-CHANGE;
N2O; AGRICULTURE; NITROGEN; NO
AB Conversion of native vegetation to cropland and intensification of agriculture typically result in increased greenhouse gas (GHG) emissions (mainly N(2)O and CH(4)) and more NO(3) leached below the root zone and into waterways. Agricultural soils are often a source but can also be a sink of CO(2). Regional and larger scale estimates of GHG emissions are usually obtained using IPCC emission factor methodology, which is associated with high uncertainty. To more realistically represent GHG emissions we used the DAYCENT biogeochemical model for non-rice major crop types (corn, wheat, soybean). IPCC methodology estimates N losses from croplands based solely on N inputs. In contrast, DAYCENT accounts for soil class, daily weather, historical vegetation cover, and land management practices such as crop type, fertilizer additions, and cultivation events. Global datasets of weather, soils, native vegetation, and cropping fractions were mapped to a 1.9 degrees x 1.9 degrees resolution. Non-spatial data (e.g., rates and dates of fertilizer applications) were assumed to be identical within crop types across regions. We compared model generated baseline GHG emissions and N losses for irrigated and rainfed cropping with land management alternatives intended to mitigate GHG emissions. Reduced fertilizer resulted in lower N losses, but crop yields were reduced by a similar proportion. Use of nitrification inhibitors and split fertilizer applications both led to increased (similar to 6%) crop yields but the inhibitor led to a larger reduction in N losses (similar to 10%). No-till cultivation, which led to C storage. combined with nitrification inhibitors, resulted in reduced GHG emissions of similar to 50% and increased crop yields of similar to 7%. Published by Elsevier B.V.
C1 [Del Grosso, Stephen J.] ARS, USDA, Nat Resources Res Ctr, Ft Collins, CO 80526 USA.
[Del Grosso, Stephen J.; Ojima, Dennis S.; Parton, William J.] Colorado State Univ, Nat Resource Ecol Lab, Ft Collins, CO 80523 USA.
[Stehfest, Elke; Heistermann, Maik] Univ Kassel, Ctr Environm Syst Res, Kassel, Germany.
[DeAngelo, Benjamin; Rose, Steven] US EPA, Washington, DC 20460 USA.
RP Del Grosso, SJ (reprint author), ARS, USDA, Nat Resources Res Ctr, 2150 Ctr Ave,Bldg D,Suite 100, Ft Collins, CO 80526 USA.
EM delgro@nrel.colostate.edu
RI Ojima, Dennis/C-5272-2016
NR 34
TC 65
Z9 65
U1 8
U2 66
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0921-8181
J9 GLOBAL PLANET CHANGE
JI Glob. Planet. Change
PD MAY
PY 2009
VL 67
IS 1-2
SI SI
BP 44
EP 50
DI 10.1016/j.gloplacha.2008.12.006
PG 7
WC Geography, Physical; Geosciences, Multidisciplinary
SC Physical Geography; Geology
GA 455JC
UT WOS:000266754000006
ER
PT J
AU Yamasaki, A
Araki, S
Sakai, R
Voorhees, AS
AF Yamasaki, Akiko
Araki, Shunichi
Sakai, Ryoji
Voorhees, A. Scott
TI Suicide Mortality of Young, Middle-aged and Elderly Males and Females in
Japan for the Years 1953-96: Time Series Analysis for the Effects of
Unemployment, Female Labour Force, Young and Aged Population, Primary
Industry and Population Density (vol 46, pg 541, 2008)
SO INDUSTRIAL HEALTH
LA English
DT Correction
DE Suicide; Unemployment; Female labour force; Young and aged population;
Japan; Time series analysis
AB Effects of nine social life indicators on age-adjusted and age-specific annual suicide mortality of male and female Japanese population in the years 1953-96 were investigated by multiple regression analysis on time series data. Unemployment rate was significantly related to the age-adjusted mortality in both males and females. Also, female labour force participation was positively related to the male mortality; persons and 65 and above was inversely related to the male mortality. Results on the age-specific mortality indicated that: during the 44 yr, (1) unemployment significantly related with the mortality of young, middle-aged and elderly males and young females; (2) female labour force participation significantly related with the mortality of young and elderly males and young females; aged population significantly related with the mortality of middle-aged and elderly males; (4) young population significantly related with the mortality of young and middle-aged males and females; (5) divorce significantly related with the mortality of middle-aged and elderly males and young males and females; (6) persons employed in primary industries significantly related with the mortality in middle-aged males and young males and females; and (7) population density significantly related with the mortality of middle-aged males and young females.
C1 [Yamasaki, Akiko] Kyoto Univ, Grad Sch Med, Dept Hlth Promot & Human Behav, Sakyo Ku, Kyoto 6068501, Japan.
[Yamasaki, Akiko] Osaka Univ, Res Inst Sustainabil Sci, Suita, Osaka 5650871, Japan.
[Araki, Shunichi] Natl Inst Occupat Safety & Hlth, Tokyo 2040024, Japan.
[Sakai, Ryoji] Union Risk Management Prevent Med, Bunkyo Ku, Tokyo 1130033, Japan.
[Voorhees, A. Scott] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Yamasaki, A (reprint author), Kyoto Univ, Grad Sch Med, Dept Hlth Promot & Human Behav, Sakyo Ku, Kyoto 6068501, Japan.
EM otsu-tky@umin.ac.jp
NR 1
TC 1
Z9 1
U1 2
U2 6
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
J9 IND HEALTH
JI Ind. Health
PD MAY
PY 2009
VL 47
IS 3
SI SI
BP 343
EP 344
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 450TV
UT WOS:000266424700017
ER
PT J
AU Senthilselvan, A
Dosman, JA
Chenard, L
Burch, LH
Predicala, BZ
Sorowski, R
Schneberger, D
Hurst, T
Kirychuk, S
Gerdts, V
Cormier, Y
Rennie, DC
Schwartz, DA
AF Senthilselvan, Ambikaipakan
Dosman, James A.
Chenard, Liliane
Burch, Lauranell H.
Predicala, Bernardo Z.
Sorowski, Randine
Schneberger, David
Hurst, Tom
Kirychuk, Shelley
Gerdts, Volker
Cormier, Yvon
Rennie, Donna C.
Schwartz, David A.
TI Toll-like receptor 4 variants reduce airway response in human subjects
at high endotoxin levels in a swine facility
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Article
DE Airway hyperresponsiveness; blood counts; cytokines; endotoxin;
gene-environment interaction; lung function; swine confinement facility;
Toll-like receptor 4 variants
ID GENE-ENVIRONMENT INTERACTIONS; LUNG-FUNCTION DECLINE; SOLUBLE CD14
LEVELS; SERUM IGE LEVELS; CONFINEMENT BUILDINGS; PIG FARMERS;
PULMONARY-FUNCTION; DUST; POLYMORPHISMS; EXPOSURE
AB Background: Toll-like receptor 4 (TLR4) variants have been shown to reduce the respiratory responses to inhaled LPS in controlled experiments among healthy volunteers.
Objective: We sought to investigate whether naive subjects with TLR4 variants showed reduced respiratory response to a complex aerosol including endotoxin as a major constituent.
Methods: Twenty-nine nonsmoking, nonatopic healthy subjects with TLR4 299/399 polymorphisms and 29 age- and sex-matched, wild-type TLR4 control subjects were exposed for 5 hours each in a noncontaminated environment (baseline day) and in a swine confinement facility (exposure day). There were 16 men and 13 women in each of the 2 age- and sex-matched groups.
Results: TLR4 polymorphic subjects who were exposed to high endotoxin levels (>= 1550 EU/m(3)) had less reduction in the percentage across-shift change in FEV(1) from baseline than did wild-type subjects exposed to similar endotoxin levels. Among subjects exposed to higher endotoxin levels, the mean differences in the percentage across-shift changes between baseline and exposure days were significantly less in TLR4 polymorphic subjects compared with those seen in wild-type subjects in FEV(1) (-8.48% +/- 1.52% [mean +/- SE] vs -11.46% +/- 1.79%, P = .001), forced expiratory flow between 25% and 75% of forced vital capacity (-18.30% +/- 1.99% vs -24.14% +/- 3.28%, P = .009), and FEV(1)/forced vital capacity ratio (-5.40% +/- 0.56% vs -8.53% +/- 1.51%, P = .04). These patterns were not observed in IL-6 levels from serum and nasal lavage fluid, IL-8 levels from nasal lavage fluid, white blood cell counts, or blood differential counts.
Conclusion: The association between TLR4 variants and reduced airway responsiveness to inhaled particulate was observed at high endotoxin concentrations, creating the possibility of certain threshold phenomena for the apparent protective effect of TLR4 variants. (J Allergy Clin Immunol 2009;123:1034-40.)
C1 [Senthilselvan, Ambikaipakan] Univ Alberta, Sch Publ Hlth, Dept Publ Hlth Sci, Edmonton, AB T6G 2G3, Canada.
[Dosman, James A.; Chenard, Liliane; Sorowski, Randine; Schneberger, David; Kirychuk, Shelley; Rennie, Donna C.] Univ Saskatchewan, Candian Ctr Hlth & Safety Agr, Saskatoon, SK, Canada.
[Gerdts, Volker] Univ Saskatchewan, Vaccine & Infect Dis Org, Saskatoon, SK, Canada.
[Burch, Lauranell H.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Predicala, Bernardo Z.] Prairie Swine Ctr Inc, Saskatoon, SK, Canada.
[Hurst, Tom] Univ Saskatchewan, Dept Med, Saskatoon, SK S7N 0W0, Canada.
[Cormier, Yvon] Univ Laval, Quebec City, PQ, Canada.
[Schwartz, David A.] Natl Jewish Hlth, Denver, CO USA.
RP Senthilselvan, A (reprint author), Univ Alberta, Sch Publ Hlth, Dept Publ Hlth Sci, 13-106B Clin Sci Bldg, Edmonton, AB T6G 2G3, Canada.
EM sentil@ualberta.ca
FU Advancing Canadian Agriculture and Agri-Food Saskatchewan; National
Science and Engineering Research Council (Canada); Saskatchewan
Agriculture Development Fund; Alberta Agriculture and Food Council;
Canadian Institutes for Health Research; Bill & Melinda Gates
Foundation; Alberta Agriculture Funding Consortium; Canadian Lung
Association
FX Disclosure of potential conflict of interest: B. Predicala has received
research support from Advancing Canadian Agriculture and Agri-Food
Saskatchewan, the National Science and Engineering Research Council
(Canada), the Saskatchewan Agriculture Development Fund, and the Alberta
Agriculture and Food Council. S. Kirychuk has received research support
from the Canadian Institutes for Health Research. V Gerdts has received
research support from the Bill & Melinda Gates Foundation, the Canadian
Institutes of Health Research, the National Sciences and Engineering
Council (Canada), and the Alberta Agriculture Funding Consortium. D. C.
Rennie has received research support from the Canadian Lung Association.
D. A. Schwartz has patent rights through MedImmune. The rest of the
authors have declared that they have no conflict of interest.
NR 34
TC 19
Z9 19
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0091-6749
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD MAY
PY 2009
VL 123
IS 5
BP 1034
EP 1040
DI 10.1016/j.jaci.2009.02.019
PG 7
WC Allergy; Immunology
SC Allergy; Immunology
GA 449CW
UT WOS:000266309400008
PM 19368968
ER
PT J
AU Visness, CM
London, SJ
Daniels, JL
Kaufman, JS
Yeatts, KB
Siega-Riz, AM
Liu, AH
Calatroni, A
Zeldin, DC
AF Visness, Cynthia M.
London, Stephanie J.
Daniels, Julie L.
Kaufman, Jay S.
Yeatts, Karin B.
Siega-Riz, Anna-Maria
Liu, Andrew H.
Calatroni, Agustin
Zeldin, Darryl C.
TI Association of obesity with IgE levels and allergy symptoms in children
and adolescents: Results from the National Health and Nutrition
Examination Survey 2005-2006
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Article
DE Atopy; allergen-specific IgE; total IgE; body mass index; obesity;
overweight; allergic disease; inflammation
ID BODY-MASS INDEX; ASTHMA; OVERWEIGHT; ATOPY; CONSUMPTION; PREVALENCE;
FATNESS; DRINKS; ADULTS
AB Background: The prevalence of both obesity and allergic disease has increased among children over the last several decades. Previous literature on the relationship between obesity and allergic disease has been inconsistent. It is not known whether systemic inflammation could be a factor in this relationship.
Objective: We sought to examine the association of obesity with total and allergen-specific IgE levels and allergy symptoms in US children and adolescents and to assess the role of C-reactive protein.
Methods: National Health and Nutrition Examination Survey data from 2005-2006 included measurement of total and allergen-specific IgE levels and allergy questions. Overweight was defined as the 85th or greater to less than the 95th percentile of body mass index for age, and obesity was defined as the 95th percentile or greater. Linear and logistic regression models were used to examine the association of weight categories with total IgE levels, atopy, allergen-specific IgE levels, and allergy symptoms among youth aged 2 to 19 years.
Results: Geometric mean total IgE levels were higher among obese (geometric mean ratio, 1.31; 95% CI, 1.10-1.57) and overweight (ratio, 1.25; 95% CI, 1.02-1.54) children than among normal-weight children. The odds ratio (OR) for atopy (any positive specific IgE measurement) was increased in the obese children compared with that seen in those of normal weight; this association was driven largely by allergic sensitization to foods (OR for atopy, 1.26 [95% CI, 1.03-1.55]; OR for food sensitization, 1.59 [95% CI, 1.28-1.98]). C-reactive protein levels were associated with total IgE levels, atopy, and food sensitization.
Conclusions: Obesity might be a contributor to the increased prevalence of allergic disease in children, particularly food allergy. Systemic inflammation might play a role in the development of allergic disease. (J Allergy Clin Immunol 2009;123:1163-9.)
C1 [Visness, Cynthia M.; Calatroni, Agustin] Rho Fed Syst Div Inc, Chapel Hill, NC 27517 USA.
[Visness, Cynthia M.; Daniels, Julie L.; Kaufman, Jay S.; Yeatts, Karin B.; Siega-Riz, Anna-Maria] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.
[London, Stephanie J.; Zeldin, Darryl C.] Natl Inst Environm Hlth Sci, Div Intramural Res, Res Triangle Pk, NC USA.
[Liu, Andrew H.] Natl Jewish Hlth, Denver, CO USA.
[Liu, Andrew H.] Univ Colorado, Hlth Sci Ctr, Denver, CO USA.
RP Visness, CM (reprint author), Rho Fed Syst Div Inc, 6330 Quadrangle Dr,Suite 500, Chapel Hill, NC 27517 USA.
EM cindy_visness@rhoworld.com
OI Kaufman, Jay/0000-0003-1606-401X; London, Stephanie/0000-0003-4911-5290
FU National Institutes of Health; National Institute of Environmental
Health Sciences [Z01 ES025041-10]; National Institute of Allergy and
Infections Diseases; National Institutes of Health [NO1-A1-25482]
FX Supported in part by the Intramural Research Program of the National
Institutes of Health, National Institute of Environmental Health
Sciences(Z01 ES025041-10), and by the National Institute of Allergy and
Infections Diseases, National Institutes of Health (NO1-A1-25482).
NR 25
TC 66
Z9 70
U1 0
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0091-6749
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD MAY
PY 2009
VL 123
IS 5
BP 1163
EP 1169
DI 10.1016/j.jaci.2008.12.1126
PG 7
WC Allergy; Immunology
SC Allergy; Immunology
GA 449CW
UT WOS:000266309400027
PM 19230960
ER
PT J
AU Liu, XY
Krebs, K
Guo, ZS
Roache, N
AF Liu, Xiaoyu
Krebs, Kenneth
Guo, Zhishi
Roache, Nancy
TI Method development for liquid chromatographic/triple quadrupole mass
spectrometric analysis of trace level perfluorocarboxylic acids in
articles of commerce
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Method development; LC/MS/MS analysis; Perfluorocarboxylic acids
(PFCAs); Articles of commerce (AOCs)
ID PERFLUORINATED CARBOXYLIC-ACIDS; PERFLUOROOCTANOIC ACID; PERFLUOROALKYL
SURFACTANTS; EXPOSURE; SAMPLES; WATER; PERFLUOROCHEMICALS; CONTAMINANTS;
QUANTITATION; EXTRACTION
AB An analytical method to identify and quantify trace levels of C5-C12 perfluorocarboxylic acids (PFCAs) in articles of commerce (AOCs) was developed and rigorously validated. Solid samples were extracted in methanol, and liquid samples were diluted with a solvent consisting of 60:40 (v/v) methanol and 2 mM ammonium acetate (NH(4)Ac) aqueous solution. in both cases, the samples were spiked with an isotopically labeled recovery check standard. The samples were concentrated in a nitrogen atmosphere (solid samples only), filtered, and then analyzed by HPLC coupled with a tandem mass spectrometer. Method evaluation included selection of the extraction solvent and the sample preparation solvent used to facilitate sample injection into the analytical system, method comparison for extraction and sample concentration, determination of extraction efficiency, instrument and method detection limits, and determination of potential sample loss during filtration and sample storage. Results of consecutive extractions demonstrated that a single extraction step accounts for 70-100% of the "total" PFCAs in the AOCs with the exception of cook-ware. The instrument's detection limit was <= 0.05 ng/mL, and the method detection limit were 1.0-3.9 ng/g for solid AOCs and 1.1-6.8 ng/g for liquid AOCs. The method has been used to determine the PFCA content in a wide range of AOCs containing or treated with fluoropolymers and fluorotelomers. Published by Elsevier B.V.
C1 [Liu, Xiaoyu; Krebs, Kenneth; Guo, Zhishi] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Roache, Nancy] ARCADIS, Durham, NC 27713 USA.
RP Liu, XY (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM liu.xiaoyu@epa.gov
FU U.S. EPA
FX We thank Andrew Lindstrom, Mark Strynar, and Shoji Nakayama of the U.S.
EPA, and Timothy Begley of the U.S. FDA for technical consultation and
assistance and Robert Wright of the U.S. EPA for QA support.
NR 30
TC 13
Z9 13
U1 2
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0021-9673
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD MAY 1
PY 2009
VL 1216
IS 18
BP 3910
EP 3918
DI 10.1016/j.chroma.2009.02.087
PG 9
WC Biochemical Research Methods; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA 440KT
UT WOS:000265699900031
PM 19303601
ER
PT J
AU Froede, CR
AF Froede, Carl R., Jr.
TI The Return of 1717 Isle Dauphine (USA)
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Isle Dauphine; Dauphin Island; Pelican-Sand Island; Mobile Bay ebb-tidal
delta; northern Gulf of Mexico
AB Dauphin Island is a segmented, microtidal barrier island, located in the northern Gulf of Mexico, approximately 8.0 km offshore from southwestern Alabama (United States). It was first mapped by Spanish explorers in 1519 but was not settled until 1699 after being claimed as a French possession. In 1707, the French officially named it Isle Dauphine. Maps of the island from this French colonial period reveal a different morphology than subsequent maps. The first American maps of Dauphin Island and Mobile Bay show two small islands (i.e., Pelican and Sand islands) offshore from the southeastern end of Dauphin Island. Passing storms have moved and reshaped both of these delta margin islands around the south-southwestern periphery of the submerged Mobile Bay ebb-tidal delta. Only in the past 25 years have the two islands combined to slowly move in a northwesterly arc toward Dauphin Island. In early 2008, continued longshore drift and strong tides have combined Pelican-Sand Island and Dauphin Island forming an island similar in morphology to that previously documented by French geographers in 1717.
C1 US EPA, Atlanta, GA 30303 USA.
RP Froede, CR (reprint author), US EPA, Reg 4 61 Forsyth St SW, Atlanta, GA 30303 USA.
NR 10
TC 0
Z9 0
U1 0
U2 1
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD MAY
PY 2009
VL 25
IS 3
BP 793
EP 795
DI 10.2112/08-1176.1
PG 3
WC Environmental Sciences; Geography, Physical; Geosciences,
Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 447HN
UT WOS:000266182300023
ER
PT J
AU Kahn, HD
Stralka, K
AF Kahn, Henry D.
Stralka, Kathleen
TI Estimated daily average per capita water ingestion by child and adult
age categories based on USDA's 1994-1996 and 1998 continuing survey of
food intakes by individuals
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE water ingestion; risk assessment; infants and children; body weight
distributions
AB Water ingestion estimates are important for the assessment of risk to human populations of exposure to water-borne pollutants. This paper reports mean and percentile estimates of the distributions of daily average per capita water ingestion for a number of age range groups. The age ranges, based on guidance from the US EPA's Risk Assessment Forum, are narrow for younger ages when development is rapid and wider for older ages when the rate of development decreases. Estimates are based on data from the United States Department of Agriculture's (USDA's) 1994-1996 and 1998 Continuing Survey of Food Intake by Individuals (CSFII). Water ingestion estimates include water ingested directly as a beverage and water added to foods and beverages during preparation at home or in local establishments. Water occurring naturally in foods or added by manufacturers to commercial products ( beverage or food) is not included. Estimates are reported in milliliters (ml/person/day) and milliliters per kilogram of body weight (ml/kg/day). As a by-product of constructing estimates in terms of body weight of respondents, distributions of self-reported body weights based on the CSFII were estimated and are also reported here.
C1 [Kahn, Henry D.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC USA.
[Stralka, Kathleen] Sci Applicat Int Corp, Falls Church, VA USA.
RP Kahn, HD (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Assessment, MC 8623D, Washington, DC USA.
EM kahn.henry@epa.gov
NR 14
TC 7
Z9 8
U1 1
U2 4
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD MAY
PY 2009
VL 19
IS 4
BP 396
EP 404
DI 10.1038/jes.2008.29
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 435OE
UT WOS:000265352400006
PM 18478044
ER
PT J
AU Richter, W
Hart, TF
Luben, T
Freud, S
Nuckols, JR
AF Richter, Wayne
Hart, Thomas F., Jr.
Luben, Thomas
Freud, Salome
Nuckols, John R.
TI Evaluation of two methods of interpolating quarterly trihalomethane
levels between sampling dates
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE disinfection byproducts; trihalomethanes; exposure; drinking water;
interpolation; spline
ID DISINFECTION BY-PRODUCTS; PUBLIC WATER-SUPPLIES; ADVERSE PREGNANCY
OUTCOMES; DRINKING-WATER; BIRTH OUTCOMES; EXPOSURE ASSESSMENT;
NORTH-CAROLINA; STILLBIRTH; RISK; CONTAMINANTS
AB Epidemiological studies of the relationship between disinfection byproducts (DBPs) and adverse birth outcomes often use a single quarterly sample result to characterize an exposure period during a pregnancy. Concentrations of trihalomethanes (THMs), a frequently studied class of DBPs, can fluctuate considerably between sampling periods so that a single point measurement in time may not adequately characterize levels over an exposure period. In addition to obtaining compliance samples that are required quarterly at a limited number of sampling sites, the New York City water supply system takes monthly THM samples at a large number of sites. We used these monthly data to investigate two methods for interpolating between quarterly measurements: cubic splines and linear interpolation. We based interpolations on 1 month in each calendar quarter and checked the interpolated values against the actual data values from the other 2 months of the quarter. Both methods produced generally acceptable fits: 90% of the observed discrepancies between fitted and actual values were less than 14 mu g/l and over half were less than 5 mu g/l for total trihalomethanes (THM4). These numbers are about half the change in THM4 level from one quarter to the next and compare favorably with the range of 0-80 mu g/l or more used in many studies. Comparable results were obtained for chloroform and bromodichloromethane, the two THMs with levels high enough to analyze. Linear interpolation generally performed better than the spline fit, producing lower average discrepancies and fewer large discrepancies. Linear interpolation can be a useful and easily applied method for developing improved exposure estimates using quarterly sampling data.
C1 [Richter, Wayne] New York State Dept Hlth, Bur Water Supply Protect, Troy, NY 12180 USA.
[Luben, Thomas] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
[Freud, Salome] New York City Dept Environm Protect, Flushing, NY USA.
[Nuckols, John R.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
RP Richter, W (reprint author), New York State Dept Hlth, Bur Water Supply Protect, 547 River St, Troy, NY 12180 USA.
EM wxr04@health.state.ny.us
FU United States Centers for Disease Control and Prevention under their
Environmental and Health Effect Tracking initiative [U50/CCU223284-01]
FX We thank Allison F. Hinckley and Gwen Babcock for SAS programming and
Roger Sokol for assisting with data interchange. Richter was supported
by Grant U50/CCU223284-01 from the United States Centers for Disease
Control and Prevention under their Environmental and Health Effect
Tracking initiative.
NR 29
TC 4
Z9 4
U1 2
U2 13
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD MAY
PY 2009
VL 19
IS 4
BP 405
EP 413
DI 10.1038/jes.2008.30
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 435OE
UT WOS:000265352400007
PM 18506206
ER
PT J
AU Martyniuk, CJ
Alvarez, S
McClung, S
Villeneuve, DL
Ankley, GT
Denslow, ND
AF Martyniuk, Christopher J.
Alvarez, Sophie
McClung, Scott
Villeneuve, Daniel L.
Ankley, Gerald T.
Denslow, Nancy D.
TI Quantitative Proteomic Profiles of Androgen Receptor Signaling in the
Liver of Fathead Minnows (Pimephales promelas)
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE iTRAQ; quantitative proteomics; androgens; antiandrogen; gene
expression; oxidative stress; toxicoproteomics
ID GOLDFISH CARASSIUS-AURATUS; PROSTATE-CANCER CELLS; ANTIANDROGEN
FLUTAMIDE; OXIDATIVE STRESS; REPRODUCTIVE ENDOCRINOLOGY;
MASS-SPECTROMETRY; PROTEIN; EXPRESSION; MICROARRAY; RESPONSES
AB Androgenic chemicals are present in the environment at concentrations that impair reproductive processes in fish. The objective of this experiment was to identify proteins and cell processes mediated through androgen receptor signaling using an androgen receptor agonist (17 beta-trenbolone) and antagonist (flutamide) in the liver. Female fathead minnows were exposed to nominal concentrations of either 17 beta-trenbolone (0.05, 0.5, or 5 mu g/L), flutamide (50, 150, or 500 mu g/L), or a mixture (500 mu g flutamide/L and 0.5 mu g 17 beta-trenbolone/L) for 48 h. The iTRAQ method was used to label peptides after protein extraction and trypsin-digestion from livers of untreated controls or from fish treated with 17 beta-trenbolone (5 mu g/L), flutamicle (500 mu g/L), or a mixture of both compounds. Forty-five proteins were differentially altered by one or more treatments (p < 0.05). Many altered proteins were involved in cellular metabolism (e.g., glyceraldehyde 3-phosphate dehydrogenase, phosphoglycerate mutase), general and oxidative stress response (e.g., superoxide dismutase and heat shock proteins), and the regulation of translation (e.g., ribosomal proteins). Cellular pathway analysis identified additional signaling cascades activated or inhibited by flutamide that may not be androgen receptor mediated. We also compared changes in select proteins to changes in their mRNA levels and observed, in general, that proteins and mRNA changes did not correlate, suggesting complex regulation at the level of both the transcriptome and proteome. It is concluded that both transcriptomic and proteomic approaches offer unique and complementary insights into mechanisms of regulation. We demonstrate the utility of proteomic profiling for use on a model species with value to ecotoxicology but having limited genomic information.
C1 [Denslow, Nancy D.] Univ Florida, Ctr Environm & Human Toxicol, Dept Physiol Sci, Gainesville, FL 32611 USA.
[Alvarez, Sophie; McClung, Scott] Univ Florida, Interdisciplinary Ctr Biotechnol Res, Gainesville, FL 32611 USA.
[Villeneuve, Daniel L.; Ankley, Gerald T.] US EPA, ORD, NHEERL, MED, Duluth, MN 55804 USA.
RP Denslow, ND (reprint author), Univ Florida, Ctr Environm & Human Toxicol, Dept Physiol Sci, POB 110885, Gainesville, FL 32611 USA.
EM ndenslow@ufl.edu
RI Alvarez, Sophie/K-9231-2013
OI Alvarez, Sophie/0000-0001-8550-2832
FU NSERC; EPA [11831848]; National Institute of Environmental Health
Sciences [RO1 ES015449]
FX The research was supported by NSERC postdoctoral fellowship to C.J.M.
and by the Environmental Protection Agency STAR grant, EPA (11831848).
This work was also supported by the Superfund Basic Research Program
from the National Institute of Environmental Health Sciences RO1
ES015449 to N.D. We also thank Li Lu for discussions involving database
searches. L. Blake, E. Durban, M. Kahl, K. Jensen and E. Makynen
provided valuable technical assistance for this work.
NR 58
TC 35
Z9 36
U1 3
U2 27
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
J9 J PROTEOME RES
JI J. Proteome Res.
PD MAY
PY 2009
VL 8
IS 5
BP 2186
EP 2200
DI 10.1021/pr800627n
PG 15
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA 441BW
UT WOS:000265745300007
PM 19267455
ER
PT J
AU Barth, EF
Reponen, T
Succop, P
AF Barth, Edwin F.
Reponen, Tiina
Succop, Paul
TI Evaluation of Bioaerosol Components, Generation Factors, and Airborne
Transport Associated with Lime Treatment of Contaminated Sediment
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID WATER TREATMENT PLANTS; SWINE CONFINEMENT BUILDINGS; WASTE-WATER;
EXPOSURE; MICROORGANISMS; BACTERIA; HEALTH; ENDOTOXIN; WORKERS;
IDENTIFICATION
AB Lime treatment has been used in contaminated sediment management activities for many purposes such as dewatering, improvement of physical properties, and reducing contaminant mobility. Exothermic volatilization of volatile organic compounds from lime-treated sediment is well known, but potential aerosolization of bioaerosol components has not been evaluated. A physical model of a contaminated sediment treatment and airborne transport process and an experimental protocol were developed to identify specific bioaerosol components (bacteria, fungi, cell structural components, and particles) that may be aerosolized and transported. Key reaction variables (amount of lime addition, rate of lime addition, mixing energy supplied) that may affect the aerosolization of bioaerosol components were evaluated. Lime treatment of a sediment contaminated with heavy metals, petroleum-based organics, and microorganisms increased the sediment pH and solids content. Lime treatment reduced the number of water-extractable bacteria and fungi in the sediment from approximately 106 colony-forming units (CFU) . mL(-1) to less than the detection limit of 10(3) CFU . mL(-1). This reduction was seen immediately for bacteria and within 21 days for fungi. Lime treatment immediately reduced the amount of endotoxin in the sediment, but the effects of lime treatment on P-D-glucan could not be determined. The temperature of the treated sediment was linearly related to the amount of lime added within the range of 0-25%. Bacteria were aerosolized during the treatment trials, but there was no culturable evidence of aerosolization of fungi, most likely because of either their particular growth stage or relatively larger particle size that reduced their aerosolization potential and their collection into the impingers. Nonbiological particles, endotoxin, and P-D-glucan were not detected in air samples during the treatment trials. The amount of lime added to the reaction beaker and the relative amount of mixing energy supplied to the reaction significantly affected the aerosolization ratio of bacteria (amount of aerosolized bacteria divided by the amount of bacteria in untreated sediment) from the reaction beaker. The rate of lime addition did not significantly affect the aerosolization ratio of bacteria. The aerosolization results suggest that exposure to bacteria is possible with sediment treatment activities, but the hazard level could not be determined because speciation of the aerosolized bacteria for pathogen identification was not performed, and health and safety standards and criteria for bioaerosol components have not been developed. Quantitative scaling analysis and whether the system represents actual environmental conditions were not studied.
C1 [Barth, Edwin F.] US EPA, Natl Risk Management Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
[Reponen, Tiina] Univ Cincinnati, Dept Environm Hlth, Ctr Hlth Related Aerosol Studies, Cincinnati, OH USA.
[Succop, Paul] Univ Cincinnati, Dept Environm Hlth, Div Epidemiol & Biostat, Cincinnati, OH USA.
RP Barth, EF (reprint author), US EPA, Natl Risk Management Res Lab, Off Res & Dev, 26 Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM barth.ed@epa.gov
NR 53
TC 3
Z9 4
U1 1
U2 2
PU AIR & WASTE MANAGEMENT ASSOC
PI PITTSBURGH
PA ONE GATEWAY CENTER, THIRD FL, PITTSBURGH, PA 15222 USA
SN 1047-3289
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PD MAY
PY 2009
VL 59
IS 5
BP 540
EP 552
DI 10.3155/1047-3289.59.5.540
PG 13
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA 441IT
UT WOS:000265763200004
PM 19583154
ER
PT J
AU Scheffe, RD
Solomon, PA
Husar, R
Hanley, T
Schmidt, M
Koerber, M
Gilroy, M
Hemby, J
Watkins, N
Papp, M
Rice, J
Tikvart, J
Valentinetti, R
AF Scheffe, Richard D.
Solomon, Paul A.
Husar, Rudolf
Hanley, Tim
Schmidt, Mark
Koerber, Michael
Gilroy, Michael
Hemby, James
Watkins, Nealson
Papp, Michael
Rice, Joann
Tikvart, Joe
Valentinetti, Ricard
TI The National Ambient Air Monitoring Strategy: Rethinking the Role of
National Networks
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID MATTER SUPERSITES PROGRAM; FINE PARTICULATE MATTER; EASTERN
UNITED-STATES; MODEL DESCRIPTION; MASS; AMMONIA; HEALTH; PM2.5; FIELD
AB A current re-engineering of the United States routine ambient monitoring networks intended to improve the balance in addressing both regulatory and scientific objectives is addressed in this paper. Key attributes of these network modifications include the addition of collocated instruments to produce multiple pollutant characterizations across a range of representative urban and rural locations in a new network referred to as the National Core Monitoring Network (NCore). The NCore parameters include carbon monoxide (CO), sulfur dioxide (SO,), reactive nitrogen (NOy), ozone (O-3), and ammonia (NH3) gases and the major fine particulate matter (PM2.5) aerosol components (ions, elemental and organic carbon fractions, and trace metals). The addition of trace gas instruments, deployed at existing chemical speciation sites and designed to capture concentrations well below levels of national air quality standards, is intended to support both long-term epidemiological studies and regional-scale air quality model evaluation. In addition to designing the multiple pollutant NCore network, steps were taken to assess the current networks on the basis of spatial coverage and redundancy criteria, and mechanisms were developed to facilitate incorporation of continuously operating particulate matter instruments.
C1 [Scheffe, Richard D.; Hanley, Tim; Schmidt, Mark; Hemby, James; Watkins, Nealson; Papp, Michael; Rice, Joann; Tikvart, Joe] US EPA, Off Air Qual Planning & Stand, Off Air & Radiat, Res Triangle Pk, NC 27711 USA.
[Solomon, Paul A.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Las Vegas, NV 89193 USA.
[Husar, Rudolf] Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO USA.
[Koerber, Michael] Lake Michigan Air Directors Consortium, Rosemont, IL USA.
[Gilroy, Michael] Puget Sound Clean Air Agcy, Seattle, WA USA.
[Valentinetti, Ricard] Vermont Agcy Nat Resources, Waterbury, VT USA.
RP Scheffe, RD (reprint author), US EPA, Off Air Qual Planning & Stand, Off Air & Radiat, 4201 Alexander Dr,MD-14, Res Triangle Pk, NC 27711 USA.
EM scheffe.rich@epa.gov
RI Husar, Rudolf/A-9000-2009
NR 33
TC 11
Z9 11
U1 0
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1096-2247
EI 2162-2906
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PD MAY
PY 2009
VL 59
IS 5
BP 579
EP 590
DI 10.3155/1047-3289.59.5.579
PG 12
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA 441IT
UT WOS:000265763200008
PM 19583158
ER
PT J
AU Serageldin, M
AF Serageldin, Mohamed
TI Development of Welding Emission Factors for Cr and Cr(VI) with a
Confidence Level
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID STAINLESS-STEEL; ARC; CHROMIUM; METAL; FUMES
AB Knowledge of the emission rate and release characteristics is necessary for estimating pollutant fate and transport. Because emission measurements at a facility's fence line are generally not readily available, environmental agencies in many countries are using emission factors (EFs) to indicate the quantity of certain pollutants released into the atmosphere from operations such as welding. The amount of fumes and metals generated from a welding process is dependent on many parameters, such as electrode composition, voltage, and current. Because test reports on fume generation provide different levels of detail, a common approach was used to give a test report a quality rating on the basis of several highly subjective criteria; however, weighted average EFs generated in this way are not meant to reflect data precision or to be used for a refined risk analysis. The 95% upper confidence limit (UCL) of the unknown population mean was used in this study to account for the uncertainty in the EF test data. Several parametric UCLs were computed and compared for multiple welding EFs associated with several mild, stainless, and alloy steels. Also, several nonparametric statistical methods, including several bootstrap procedures, were used to compute 95% UCLs. For the nonparametric methods, a distribution for calculating the mean, standard deviation, and other statistical parameters for a dataset does not need to be assumed. There were instances when the sample size was small and instances when EFs for an electrode/process combination were not found. Those two points are addressed in this paper. Finally, this paper is an attempt to deal with the uncertainty in the value of a mean EF for an electrode/process combination that is based on test data from several laboratories. Welding EFs developed with a defined level of confidence may be used as input parameters for risk assessment.
C1 US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Serageldin, M (reprint author), US EPA, Off Air Qual Planning & Stand, 109 TW Alexander Dr E-143-03, Res Triangle Pk, NC 27711 USA.
EM Serageldin.Mohamed@epa.gov
NR 28
TC 6
Z9 7
U1 0
U2 0
PU AIR & WASTE MANAGEMENT ASSOC
PI PITTSBURGH
PA ONE GATEWAY CENTER, THIRD FL, PITTSBURGH, PA 15222 USA
SN 1047-3289
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PD MAY
PY 2009
VL 59
IS 5
BP 619
EP 626
DI 10.3155/1047-3289.59.5.619
PG 8
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA 441IT
UT WOS:000265763200012
PM 19583162
ER
PT J
AU Wang, P
Linker, LC
AF Wang, Ping
Linker, Lewis C.
TI Assessment of Nitrogen and Phosphorus Control Trade-Offs Using a Water
Quality Model with a Response Surface Method
SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE
LA English
DT Article
ID CHESAPEAKE BAY; NUTRIENT; ESTUARY
AB Excessive nutrient loads to the Chesapeake Bay cause violations of the new dissolved oxygen water quality standard established to protect the Bay's living resources. Reducing nitrogen and phosphorus loads is necessary to achieve the dissolved oxygen standard. Based on a set of water quality model runs, a response surface method to establish a function of dissolved oxygen (DO) versus total nitrogen (TN) and total phosphorus (TP) loads was used, which plots as a three-dimensional surface. For a specific criterion for DO, i.e., achievement of the DO standard, a curve of DO versus TN and TP loads that meets the DO criterion can be isolated. Each of the paired TN and TP loads on this trade-off curve results in an equivalent level of DO, but usually at different nutrient reduction costs. This paper explores cost-effective alternatives in nutrient reduction to achieve the DO water quality standard in the deep water designated use of Segment CB4, which is the last and most difficult region for achievement of DO standards in the Chesapeake. This paper analyzes DO response surface plots and nitrogen-phosphorus trade-off curves. The effects of nutrient limitation on algal growth, water clarity, and DO concentrations in two different nitrogen and phosphorus load scenarios are examined to understand the responses of water quality to nitrogen and phosphorus trades.
C1 [Wang, Ping] Univ Maryland, Ctr Environm Sci, Annapolis, MD 21403 USA.
[Linker, Lewis C.] US EPA, Chesapeake Bay Program, Annapolis, MD 21403 USA.
RP Wang, P (reprint author), Univ Maryland, Ctr Environm Sci, 410 Severn Ave, Annapolis, MD 21403 USA.
EM pwang@chesapeakebay.net; linker.lewis@epa.gov
NR 23
TC 3
Z9 3
U1 1
U2 4
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9496
J9 J WATER RES PL-ASCE
JI J. Water Resour. Plan. Manage.-ASCE
PD MAY-JUN
PY 2009
VL 135
IS 3
BP 171
EP 177
DI 10.1061/(ASCE)0733-9496(2009)135:3(171)
PG 7
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA 434PC
UT WOS:000265285600005
ER
PT J
AU Davis, BJ
Haneke, KE
Miner, K
Kowalik, A
Barrett, JC
Peddada, S
Baird, DD
AF Davis, Barbara J.
Haneke, Karen E.
Miner, Kelly
Kowalik, Ania
Barrett, J. Carl
Peddada, Shyamal
Baird, Donna Day
TI The Fibroid Growth Study: Determinants of Therapeutic Intervention
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID PREMENOPAUSAL WOMEN; UTERINE LEIOMYOMA; AGE
AB Aims: The demographics, ethnicity, symptoms, lifestyle characteristics, and treatment outcomes are analyzed in participants of a study designed to evaluate uterine leiomyoma growth and correlate symptoms and outcomes in a clinically relevant population of women (Fibroid Growth Study).
Methods: Women included in the Fibroid Growth Study (FGS) completed a medical history and physical examination, underwent T1-weighted and T2-weighted magnetic resonance image (MRI) scans, provided urine and blood samples at each scheduled MRI, and responded to an initial extensive telephone-administered questionnaire followed by abbreviated monthly questionnaire updates. Summary scores were developed to quantify stress, pain, and bleeding. The Wilcoxin test was used for statistical comparisons between study participant characteristics and tumor-related characteristics.
Results: Participants included 116 premenopausal women, ranging in age from 20 to 54 years; 48% were black women, 41% were white women, 10% were women of other or multiple racial backgrounds, and 1% did not self-identify. Over 90% of participants had multiple leiomyomas, and nearly a third had more than 10. Black women were younger and had more fibroids, but no differences were found in the proportions of black and white women choosing an intervention; 44% of black women and 40% of white women chose intervention during the study.
Conclusions: There was no correlation between number of leiomyomas or uterine size and choosing treatment. However, women who opted for treatment were more symptomatic, with higher bleeding and pain scores, compared with the women with no intervention. Consequently, our study suggests that once women are symptomatic, black and white women choose surgery as a treatment method for the same reasons and at about the same rates. Moreover, our data suggest that bleeding and pain, not the size or multiplicity of fibroids, determine the choice for intervention. Therefore, aggressive management of pain and bleeding may be effective in reducing the need for surgical intervention.
C1 [Davis, Barbara J.; Miner, Kelly; Peddada, Shyamal; Baird, Donna Day] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Haneke, Karen E.] Integrated Syst Lab, Res Triangle Pk, NC USA.
[Kowalik, Ania] Univ N Carolina, Chapel Hill, NC USA.
[Barrett, J. Carl] NCI, Bethesda, MD 20892 USA.
RP Davis, BJ (reprint author), Millennium Pharmaceut Inc, 35 Landsdowne St, Cambridge, MA 02139 USA.
EM Barbara.Davis@MPI.com
RI Peddada, Shyamal/D-1278-2012; Baird, Donna/D-5214-2017
OI Baird, Donna/0000-0002-5544-2653
FU NIH [M01RR00046]; NIEHS; National Center for Research on Minority Health
and Health Disparities, NIH; National Uterine Fibroid Foundation
FX We gratefully acknowledge Drs. Richard Semelka, Diane Armao, Xiaoyu
Ding, Stephen Aylward, Bruce Lessey, Kimberly Cummings, Jane Schroeder,
David Walmer, and Ray Tice and Mr. Jean-Philippe Guyon for their
contributions in study design and data analysis and acknowledge the
critical contributions of Ms. Martha Turvey, who was the study nurse.
Dr. Ronald Herbert, Ms. Mary Wood, Ms. Paulette Daniel, Ms. Andrea
Emmanuel, and Dr. Pamela Blackshear were also involved in additional
study conduct, data collection, and analysis. We gratefully acknowledge
the input on our study design and questionnaires of members of the
National Uterine Fibroid Foundation.
NR 7
TC 13
Z9 14
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD MAY
PY 2009
VL 18
IS 5
BP 725
EP 732
DI 10.1089/jwh.2008.0903
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
Internal; Obstetrics & Gynecology; Women's Studies
SC Public, Environmental & Occupational Health; General & Internal
Medicine; Obstetrics & Gynecology; Women's Studies
GA 446DP
UT WOS:000266100900017
PM 19366341
ER
PT J
AU Li, ZK
Lee, K
King, T
Boufadel, MC
Venosa, AD
AF Li, Zhengkai
Lee, Kenneth
King, Thomas
Boufadel, Michel C.
Venosa, Albert D.
TI Evaluating crude oil chemical dispersion efficacy in a flow-through wave
tank under regular non-breaking wave and breaking wave conditions
SO MARINE POLLUTION BULLETIN
LA English
DT Article
DE Oil spill; Dispersant; Waves; Currents; Dynamic dispersant
effectiveness; Particle size distribution
ID BAFFLED FLASK TEST; EFFECTIVENESS PROTOCOL; DROPLET SIZE; DISSIPATION;
TURBULENCE; SPILLS; IMPACT; SEA
AB Testing dispersant effectiveness under conditions similar to that of the open environment is required for improvements in operational procedures and the formulation of regulatory guidelines. To this end, a novel wave tank facility was fabricated to study the dispersion of crude oil under regular non-breaking and irregular breaking wave conditions. This wave tank facility was designed for operation in a flow-through mode to simulate both wave- and current-driven hydrodynamic conditions. We report here an evaluation of the effectiveness of chemical dispersants (Corexit (R) EC9500A and SPC 1000 (TM)) on two crude oils (Medium South American [MESA] and Alaska North Slope [ANS]) under two different wave conditions (regular non-breaking and plunging breaking waves) in this wave tank. The dispersant effectiveness was assessed by measuring the water column oil concentration and dispersed oil droplet size distribution. In the absence of dispersants, nearly 8-19% of the test crude oils were dispersed and diluted under regular wave and breaking wave conditions. In the presence of dispersants, about 21-36% of the crude oils were dispersed and diluted under regular waves, and 42-62% under breaking waves. Consistently, physical dispersion under regular waves produced large oil droplets (volumetric mean diameter or VMD >= 300 mu m), whereas chemical dispersion under breaking waves created small droplets (VMD <= 50 mu m). The data can provide useful information for developing better operational guidelines for dispersant use and improved predictive models on dispersant effectiveness in the field. (c) 2008 Elsevier Ltd. All rights reserved.
C1 [Li, Zhengkai; Lee, Kenneth; King, Thomas] Fisheries & Oceans DFO Canada, Bedford Inst Oceanog, Ctr Offshore Oil & Gas Environm Res, Dartmouth, NS B2Y 4A2, Canada.
[Boufadel, Michel C.] Temple Univ, Dept Civil & Environm Engn, Philadelphia, PA 19122 USA.
[Venosa, Albert D.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Li, ZK (reprint author), Fisheries & Oceans DFO Canada, Bedford Inst Oceanog, Ctr Offshore Oil & Gas Environm Res, 1 Challenger Dr, Dartmouth, NS B2Y 4A2, Canada.
EM liz@dfo-mpo.gc.ca
FU Program of Energy Research and Development (PERD); US EPA [68-C-00-159];
NOAA/UNH Coastal Response Research Center [NA04NOS4190063, 06-085]
FX This research was funded by the Program of Energy Research and
Development (PERD), US EPA (Contract No.: 68-C-00-159), and NOAA/UNH
Coastal Response Research Center (NOAA Grant No.: NA04NOS4190063 UNH
Agreement No.: 06-085). The findings, opinions, and recommendations
expressed in this report are those of the authors and do not necessarily
reflect those of the funding agencies.
NR 36
TC 21
Z9 23
U1 3
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0025-326X
EI 1879-3363
J9 MAR POLLUT BULL
JI Mar. Pollut. Bull.
PD MAY
PY 2009
VL 58
IS 5
BP 735
EP 744
DI 10.1016/j.marpolbul.2008.12.014
PG 10
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 446VT
UT WOS:000266150300024
PM 19157465
ER
PT J
AU Vonderheide, AP
AF Vonderheide, Anne P.
TI A review of the challenges in the chemical analysis of the
polybrominated diphenyl ethers
SO MICROCHEMICAL JOURNAL
LA English
DT Review
DE PBDE; BFRs; Review
ID BROMINATED FLAME RETARDANTS; 2-DIMENSIONAL GAS-CHROMATOGRAPHY;
POLYCHLORINATED-BIPHENYLS PCBS; MASS-SPECTROMETRIC DETECTION; RANGE
ATMOSPHERIC TRANSPORT; IN-HOUSE DUST; DECABROMODIPHENYL ETHER;
ELECTRON-CAPTURE; COASTAL WATERS; ORGANOHALOGEN CONTAMINANTS
AB Toxicity studies coupled with recent occurrence data have resulted in a plethora of analytical papers concerning the polybrominated diphenyl ether compounds. As the need to investigate alternate and complex matrices has increased, extraction methodologies have undergone appropriate modifications and these are discussed in this review. Over the past few years, published manuscripts have extended beyond conventional analytical approaches in search of enhanced selectivity and sensitivity and these novel instrumental approaches are examined. Finally, along with this quest have come issues of quality control and data reporting and this review is also in part a critical inspection of these issues. Published by Elsevier B.V.
C1 US EPA, Off Res & Dev, Natl Exposure Res Lab, Microbiol & Chem Exposure Assessment Res Div,Chem, Cincinnati, OH 45268 USA.
RP Vonderheide, AP (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Microbiol & Chem Exposure Assessment Res Div,Chem, Cincinnati, OH 45268 USA.
EM vonderheide.anne@epa.gov
FU The United States Environmental Protection Agency, through its Office of
Research and Development
FX The United States Environmental Protection Agency, through its Office of
Research and Development, funded and managed this manuscript. It has
been subjected to the Agency's administrative review and approved for
publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 106
TC 22
Z9 22
U1 2
U2 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0026-265X
J9 MICROCHEM J
JI Microchem J.
PD MAY
PY 2009
VL 92
IS 1
BP 49
EP 57
DI 10.1016/j.microc.2008.12.011
PG 9
WC Chemistry, Analytical
SC Chemistry
GA 452DS
UT WOS:000266520800008
ER
PT J
AU DeKeyser, JG
Stagliano, MC
Auerbach, SS
Prabhu, KS
Jones, AD
Omiecinski, CJ
AF DeKeyser, Joshua G.
Stagliano, Michael C.
Auerbach, Scott S.
Prabhu, K. Sandeep
Jones, A. Daniel
Omiecinski, Curtis J.
TI Di(2-ethylhexyl) phthalate Is a Highly Potent Agonist for the Human
Constitutive Androstane Receptor Splice Variant CAR2
SO MOLECULAR PHARMACOLOGY
LA English
DT Article
ID PREGNANE-X-RECEPTOR; LIGAND-BINDING; METABOLISM; ALPHA; LIVER;
ACTIVATION; EXPRESSION; EXPOSURE; DI-(2-ETHYLHEXYL)PHTHALATE;
IDENTIFICATION
AB The human constitutive androstane receptor (CAR, CAR1) regulates the expression of genes involved in xenobiotic metabolism in the liver. The CAR gene uses multiple alternative splicing events during pre-mRNA processing, thereby enhancing the CAR transcriptome. Previous reports have identified two prominent human CAR variants, CAR2 and CAR3, that possess four- and five-amino acid insertions in their ligand binding domains, respectively. Unlike the constitutively active reference form of the receptor, we now demonstrate that CAR2 is a ligand-activated receptor and comprises approximately 30% of the reference transcript level in human liver tissues in human hepatocytes. Furthermore, we identify the common plasticizer, di(2-ethylhexyl) phthalate (DEHP), as a highly potent and uniquely selective agonist of CAR2. Results from reporter transactivation and mammalian two-hybrid assays reveal that DEHP activates CAR2 at low nanomolar concentrations, results further supported by analysis of CAR target gene expression in primary human hepatocytes. In addition, comparative genomic analyses show that the typical mouse, rat, and marmoset models of DEHP toxicity cannot accurately profile potential human toxicity because of these species' inability to generate a CAR2-like transcript. The discovery that CAR2 is an ultimate human DEHP receptor identifies a novel pathway modulating human DEHP toxicity with potential clinical implications for a subset of patients undergoing critical care medical interventions.
C1 [DeKeyser, Joshua G.; Prabhu, K. Sandeep; Omiecinski, Curtis J.] Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA.
[Stagliano, Michael C.] Penn State Univ, Dept Chem, University Pk, PA 16802 USA.
[Stagliano, Michael C.; Jones, A. Daniel] Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA.
[Jones, A. Daniel] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA.
[Auerbach, Scott S.] Natl Inst Environm Hlth Sci, Natl Toxicol Program, Res Triangle Pk, NC USA.
RP Omiecinski, CJ (reprint author), Penn State Univ, Dept Vet & Biomed Sci, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA.
EM cjo10@psu.edu
RI Jones, Arthur/C-2670-2013
OI Jones, Arthur/0000-0002-7408-6690
FU National Institutes of Health National Institute of General Medical
Sciences [GM66411]; National Institutes of Health National Institute of
Environmental Health Sciences; National Institutes of Health National
Institute of Diabetes and Digestive and Kidney Diseases
[N01-DK-7-0004/HHSN267200700004c]; National Science Foundation
[DBI-0619489]
FX This work was supported, in part, by the National Institutes of Health
National Institute of General Medical Sciences [Grant GM66411]; by the
Intramural Research program of the National Institutes of Health
National Institute of Environmental Health Sciences; and by the National
Institutes of Health National Institute of Diabetes and Digestive and
Kidney Diseases [Contract N01-DK-7-0004/HHSN267200700004c]. The Quattro
Premier XE mass spectrometer was purchased with funds from the National
Science Foundation [Grant DBI-0619489].
NR 37
TC 40
Z9 42
U1 0
U2 5
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0026-895X
J9 MOL PHARMACOL
JI Mol. Pharmacol.
PD MAY
PY 2009
VL 75
IS 5
BP 1005
EP 1013
DI 10.1124/mol.108.053702
PG 9
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 436VS
UT WOS:000265444800001
PM 19211671
ER
PT J
AU Gordon, CJ
Ward, WO
AF Gordon, Christopher J.
Ward, William O.
TI A multianalyte profile of serum proteins to screen for toxicological
effects of anticholinesterase insecticides in the rat
SO NEUROTOXICOLOGY
LA English
DT Article
DE Biomarker; Serum; Chlorpyrifos; Carbaryl
ID TIME-COURSE; CHLORPYRIFOS; EXPOSURE; EXPRESSION; FEVER; MICE
AB The development of high throughput biochemical screens could be useful to assess the broad spectrum of physiological effects of environmental toxicants. To explore the prospect of using a screen in an in vivo exposure scenario, we applied a commercially available multianalyte profile (MAP) of 58 serum biomarkers to rats exposed acutely to two anticholinesterase insecticides, chlorpyrifos (CHP) and carbaryl (CAR). Male, Long-Evans rats were dosed orally with 30 mg/kg CHP, 75 mg/kg CAR or the corn oil vehicle. Doses were selected based on their equivalent physiological effects (hypothermia and reduced motor activity). The animals were terminated 24 h or 7 days after dosing. Serum was collected and analyzed for 58 biomarkers consisting primarily of cytokines, chemokines, and a few hormones. There were changes in six analytes (four up, two down) following CHP and eight analytes (five up, three down) following CAR at 24 h. There were significant changes in only two biomarkers when measured 7 days after dosing with CHP. Overall, the MAP detected a broad spectrum of unique effects for CHP and CAR. It is concluded that the MAP is a useful tool to screen for in vivo effects of environmental toxicants and its use could lead to the discovery of novel mechanisms of action. Published by Elsevier Inc.
C1 [Gordon, Christopher J.] US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Ward, William O.] US EPA, Div Environm Carcinogenesis, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Gordon, CJ (reprint author), US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, MD B105-04,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM gordon.christopher@epa.gov
NR 14
TC 2
Z9 2
U1 1
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0161-813X
J9 NEUROTOXICOLOGY
JI Neurotoxicology
PD MAY
PY 2009
VL 30
IS 3
BP 377
EP 381
DI 10.1016/j.neuro.2009.02.009
PG 5
WC Neurosciences; Pharmacology & Pharmacy; Toxicology
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology
GA 448RH
UT WOS:000266279200006
PM 19442821
ER
PT J
AU Chen, AM
Klebanoff, MA
Basso, O
AF Chen, Aimin
Klebanoff, Mark A.
Basso, Olga
TI Pre-pregnancy body mass index change between pregnancies and preterm
birth in the following pregnancy
SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
LA English
DT Article
DE maternal body mass index; preterm delivery; consecutive pregnancies
ID POSTPARTUM WEIGHT RETENTION; GESTATIONAL-AGE; PERINATAL OUTCOMES;
BRAZILIAN WOMEN; UNITED-STATES; RISK; DELIVERY; POPULATION; COHORT;
OBESITY
AB Maternal pre-pregnancy body mass index (BMI) may affect the risk of preterm birth. However, it is unclear how changes in BMI between pregnancies modify the risk of preterm birth in the following pregnancy. We studied this effect in the Collaborative Perinatal Project, when obesity was uncommon and the prevalence of induction of labour was low. This analysis included 1892 primiparae whose first enrolled ( index) pregnancy was a singleton livebirth and the second enrolled ( outcome) pregnancy was a consecutive singleton pregnancy ( both pregnancies within 20-51 weeks of gestation). We used the Cox regression model to calculate the hazard ratio (HR) of preterm birth at the outcome pregnancy as a function of reduced BMI (<25(th) percentile of change) and increased BMI (>75(th) percentile), compared with stable BMI (25(th)-75(th) percentile), adjusted for pre-pregnancy BMI at the index pregnancy and other covariates.
Body mass index reduction was associated with a non-significant increased risk of preterm birth, adjusted HR 1.17 [95% confidence interval 0.90, 1.53]; BMI increase had effects close to null (adjusted HR 1.08 [0.83, 1.41]). In the model with linear BMI change, each 1 kg/m(2) increase was associated with an HR of 0.96 [0.89, 1.03]. The estimates associated with a BMI reduction were higher in women whose index pregnancy ended preterm (HR 1.49 [0.90, 2.44]) and in those with BMI < 25 kg/m(2) at the index pregnancy (HR 1.30 [0.98, 1.71]). This study involved mainly low-to-normal weight women with spontaneous deliveries, and might suffer from type II error owing to small sample size. The effect of BMI change in overweight and obese women needs to be studied using contemporary data.
C1 [Chen, Aimin] Creighton Univ, Sch Med, Dept Prevent Med & Publ Hlth, Omaha, NE 68178 USA.
[Klebanoff, Mark A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Epidemiol Stat & Prevent Res, NIH, Dept Hlth & Human Serv, Bethesda, MD USA.
[Basso, Olga] Natl Inst Environm Hlth Sci, Epidemiol Branch, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
RP Chen, AM (reprint author), Creighton Univ, Sch Med, Dept Prevent Med & Publ Hlth, 2500 Calif Plaza, Omaha, NE 68178 USA.
EM aiminchen@creighton.edu
RI Basso, Olga/E-5384-2010
OI Basso, Olga/0000-0001-9298-4921
FU Creighton University School of Medicine Health Future Foundation;
Intramural Research Program of the NIH; National Institute of
Environmental Health Sciences [Z01 ES044003]; Eunice Kennedy Shriver
National Institute of Child Health and Human Development
FX The study was supported by Creighton University School of Medicine
Health Future Foundation. This research was supported in part by the
Intramural Research Program of the NIH, National Institute of
Environmental Health Sciences ( Z01 ES044003), and Eunice Kennedy
Shriver National Institute of Child Health and Human Development.
NR 40
TC 15
Z9 15
U1 0
U2 3
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0269-5022
J9 PAEDIATR PERINAT EP
JI Paediatr. Perinat. Epidemiol.
PD MAY
PY 2009
VL 23
IS 3
BP 207
EP 215
DI 10.1111/j.1365-3016.2009.01029.x
PG 9
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
Pediatrics
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
Pediatrics
GA 425KL
UT WOS:000264635300003
PM 19775382
ER
PT J
AU Cairns, MA
Lajtha, K
Beedlow, PA
AF Cairns, Michael A.
Lajtha, Kate
Beedlow, Peter A.
TI Dissolved carbon and nitrogen losses from forests of the Oregon Cascades
over a successional gradient
SO PLANT AND SOIL
LA English
DT Article
DE Nitrogen; Carbon; Forest succession; Cascades; Oregon; C:N; Lysimeter;
Stream; Soil solution
ID OLD-GROWTH FOREST; ORGANIC-MATTER; DOUGLAS-FIR; HYPORHEIC ZONE; WESTERN
OREGON; NITRATE UPTAKE; LAND-USE; STREAM; WATERSHEDS; DYNAMICS
AB Ecologists have long used stream water chemistry records to infer hillslope processes, although a great deal of biogeochemical processing of soil water is known to occur both downslope and in-stream. We report the effects of forest succession on C and N export in the west central Cascades of Oregon, a region of low anthropogenic N input. In a previous study, watersheds with forests of differing ages showed a number of significant differences in stream nutrient export. This study was intended to establish whether differences in stream chemistry were due to variation in N retention by forests of different ages, and thus we measured C and N in lysimeter water draining 12 forest plots, which were categorized into four different stages of successional development. Mean total dissolved nitrogen (TDN) concentrations in deep soil solutions were 2.5 times higher than stream water TDN observed in the previous study, suggesting that denitrification and/or N uptake occurred in the streams or the riparian zone. Although there was a trend for highest soil solution N concentrations in the second youngest (stem exclusion) stage, this trend was significant only for NH(4)-N. We previously found that streamwater NO(3)-N concentrations averaged 46% of TDN export and was significantly higher in the young than in the older watersheds, however, soil solution NO(3)-N concentration averaged 2% of TDN concentration and did not vary with succession. Although NH(4)-N concentrations were very low (similar to 5 mu g L(-1)) in stream water, NH(4)-N in lysimeter samples averaged 35% of TDN. While stream water dissolved organic nitrogen (DON) concentrations averaged 30% of TDN concentrations, soil solution DON concentrations averaged 64% of TDN concentration; neither varied with succession. Even with sharp differences in both forest floor and mineral soil C:N ratios and C contents among plots, no measure of N export from the forest stands was significantly related to forest floor or mineral soil characteristics. This is most likely because forest floor C:N ratios all greatly exceeded the reported low C:N ratios required to allow significant N leakage. Taken together, these results suggest that riparian dynamics, in-stream processing, or perhaps even the presence of near-stream alders significantly alter concentrations of all N species between the soil solution and stream water.
C1 [Cairns, Michael A.] Watershed Enhancement Strategies, Independence, OR 97351 USA.
[Cairns, Michael A.; Beedlow, Peter A.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Corvallis, OR 97333 USA.
[Lajtha, Kate] Oregon State Univ, Dept Bot & Plant Pathol, Corvallis, OR 97331 USA.
RP Cairns, MA (reprint author), Watershed Enhancement Strategies, 593 E St, Independence, OR 97351 USA.
EM Michael.cairns@yahoo.com
NR 67
TC 4
Z9 4
U1 1
U2 33
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0032-079X
J9 PLANT SOIL
JI Plant Soil
PD MAY
PY 2009
VL 318
IS 1-2
BP 185
EP 196
DI 10.1007/s11104-008-9828-5
PG 12
WC Agronomy; Plant Sciences; Soil Science
SC Agriculture; Plant Sciences
GA 438EF
UT WOS:000265538000016
ER
PT J
AU Noureddine, MA
Menendez, D
Campbell, MR
Bandele, OJ
Horvath, MM
Wang, XT
Pittman, GS
Chorley, BN
Resnick, MA
Bell, DA
AF Noureddine, Maher A.
Menendez, Daniel
Campbell, Michelle R.
Bandele, Omari J.
Horvath, Monica M.
Wang, Xuting
Pittman, Gary S.
Chorley, Brian N.
Resnick, Michael A.
Bell, Douglas A.
TI Probing the Functional Impact of Sequence Variation on p53-DNA
Interactions Using a Novel Microsphere Assay for Protein-DNA Binding
with Human Cell Extracts
SO PLOS GENETICS
LA English
DT Article
ID P53 TRANSCRIPTIONAL NETWORK; GENE-EXPRESSION; HUMAN GENOME; REGULATORY
NETWORK; RESPONSE ELEMENTS; PROMOTER REGION; SITE; IDENTIFICATION;
DAMAGE; STRESS
AB The p53 tumor suppressor regulates its target genes through sequence-specific binding to DNA response elements (REs). Although numerous p53 REs are established, the thousands more identified by bioinformatics are not easily subjected to comparative functional evaluation. To examine the relationship between RE sequence variation-including polymorphisms-and p53 binding, we have developed a multiplex format microsphere assay of protein-DNA binding (MAPD) for p53 in nuclear extracts. Using MAPD we measured sequence-specific p53 binding of doxorubicin-activated or transiently expressed p53 to REs from established p53 target genes and p53 consensus REs. To assess the sensitivity and scalability of the assay, we tested 16 variants of the p21 target sequence and a 62-multiplex set of single nucleotide (nt) variants of the p53 consensus sequence and found many changes in p53 binding that are not captured by current computational binding models. A group of eight single nucleotide polymorphisms (SNPs) was examined and binding profiles closely matched transactivation capability tested in luciferase constructs. The in vitro binding characteristics of p53 in nuclear extracts recapitulated the cellular in vivo transactivation capabilities for eight well-established human REs measured by luciferase assay. Using a set of 26 bona fide REs, we observed distinct binding patterns characteristic of transiently expressed wild type and mutant p53s. This microsphere assay system utilizes biologically meaningful cell extracts in a multiplexed, quantitative, in vitro format that provides a powerful experimental tool for elucidating the functional impact of sequence polymorphism and protein variation on protein/DNA binding in transcriptional networks.
C1 [Noureddine, Maher A.; Campbell, Michelle R.; Bandele, Omari J.; Horvath, Monica M.; Wang, Xuting; Pittman, Gary S.; Chorley, Brian N.; Bell, Douglas A.] Natl Inst Environm Hlth Sci, Environm Genom Grp, Mol Genet Lab, Res Triangle Pk, NC USA.
[Menendez, Daniel; Resnick, Michael A.] Natl Inst Environm Hlth Sci, Chromosome Stabil Grp, Mol Genet Lab, Res Triangle Pk, NC USA.
RP Noureddine, MA (reprint author), Natl Inst Environm Hlth Sci, Environm Genom Grp, Mol Genet Lab, Res Triangle Pk, NC USA.
EM BELL1@niehs.nih.gov
OI Wang, Xuting/0000-0001-6781-8008
FU National Institute of Environmental Health Sciences; National Institutes
of Health [Z01-ES-100475-M-0001, Z01 ES065079-15]
FX This research was funded entirely by the Intramural Research Program of
the National Institute of Environmental Health Sciences, National
Institutes of Health (projects: Z01-ES-100475-M-0001 and Z01
ES065079-15). The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
NR 52
TC 25
Z9 25
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1553-7390
J9 PLOS GENET
JI PLoS Genet.
PD MAY
PY 2009
VL 5
IS 5
AR e1000462
DI 10.1371/journal.pgen.1000462
PG 13
WC Genetics & Heredity
SC Genetics & Heredity
GA 459EH
UT WOS:000267083000021
PM 19424414
ER
PT J
AU Lepadatu, C
Enache, M
Walker, JD
AF Lepadatu, Costinel
Enache, Monica
Walker, John D.
TI Toward a More Realistic QSAR Approach to Predicting Metal Toxicity
SO QSAR & COMBINATORIAL SCIENCE
LA English
DT Article
DE Molecular electronegativity; Metal ions; Toxicity; Sunflower
ID ION; ELECTRONEGATIVITY; CHEMISTRY; HARDNESS; WATER
AB The subject of this paper is to present molecular descriptors representing the electronegativity of OMO (occupied molecular orbital) and UMO (unoccupied molecular orbital) quantum molecular states that could be used to obtain information on the mechanism of electron transfer between metal compound and biological receptor. The molecular descriptors that were used suggested that the (s,p) and (d(N)) metal ions have different mechanisms of interaction with the receptor. This result explains why the correlation activity-descriptor is rather poor or practically does not exist when all metal ions are analyzed together (irrespective of their valence shell). Since this interaction is the last event of the long chain of processes of the metal ion up to the biological target, such molecular descriptors could be used together with other descriptors in QSAR models for prediction of biological activity.
C1 [Lepadatu, Costinel] Acad Romana, Inst Chem Phys, Bucharest 060021, Romania.
[Enache, Monica] Univ Agr Sci & Vet Med Bucharest, Fac Biotechnol, Bucharest 011464, Romania.
[Walker, John D.] US EPA, TSCA ITC, Off Pollut Prevent & Tox 7401, Washington, DC 20460 USA.
RP Lepadatu, C (reprint author), Acad Romana, Inst Chem Phys, Sp Independentei 202, Bucharest 060021, Romania.
EM walker.johnd@epa.gov
NR 19
TC 5
Z9 5
U1 0
U2 8
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY
SN 1611-020X
J9 QSAR COMB SCI
JI QSAR Comb. Sci.
PD MAY
PY 2009
VL 28
IS 5
BP 520
EP 525
DI 10.1002/qsar.200860151
PG 6
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Computer Science,
Interdisciplinary Applications; Pharmacology & Pharmacy
SC Pharmacology & Pharmacy; Chemistry; Computer Science
GA 448VN
UT WOS:000266290200003
ER
PT J
AU Genaidy, AM
Sequeira, R
Tolaymat, T
Kohler, J
Rinder, M
AF Genaidy, A. M.
Sequeira, R.
Tolaymat, T.
Kohler, J.
Rinder, M.
TI Evidence-based integrated environmental solutions for secondary lead
smelters: Pollution prevention and waste minimization technologies and
practices
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Lead; Pollution prevention; Waste minimization; Technologies; Practices
ID SHORT ROTARY FURNACE; ACID-BATTERIES; CLEANER PRODUCTION;
MINING-INDUSTRY; RECYCLING LEAD; BLAST-FURNACE; RECENT TRENDS; RECOVERY;
SCRAP; METALS
AB An evidence-based methodology was adopted in this research to establish strategies to increase lead recovery and recycling via a systematic review and critical appraisal of the published literature. In particular, the research examines pollution prevention and waste minimization practices and technologies that meet the following criteria: (a) reduce/recover/recycle the largest quantities of lead currently being disposed of as waste, (b) technically and economically viable, that is, ready to be diffused and easily transferable, and (c) strong industry interest (i.e., industry would consider implementing projects with higher payback periods). The following specific aims are designed to achieve the study objectives: Aim 1 - To describe the recycling process of recovering refined lead from scrap; Aim 2 - To document pollution prevention and waste management technologies and practices adopted by US stakeholders along the trajectory of LAB and lead product life cycle: Aim 3 - To explore improved practices and technologies which are employed by other organizations with an emphasis on the aforementioned criteria; Aim 4 - To demonstrate the economic and environmental costs and benefits of applying improved technologies and practices to existing US smelting operations; and Aim 5 - To evaluate improved environmental technologies and practices using an algorithm that integrates quantitative and qualitative criteria.
The process of identifying relevant articles and reports was documented. The description of evidence was presented for current practices and technologies used by US smelters as well as improved practices and technologies. Options for integrated environmental solutions for secondary smelters were introduced and rank ordered on the basis of costs (i.e., capital investment) and benefits (i.e., production increases, energy and flux savings, and reduction of SO(2) and slag). An example was provided to demonstrate the utility of the algorithm by detailing the costs and benefits associated with different combinations of practices and technologies. The evidence-based methodology documented in this research reveals that it is technically and economically feasible to implement integrated environmental solutions to increase lead recovery and recycling among US smelters. The working example presented in this research can be confirmed with US stakeholders and form the basis for implementable solutions in the lead smelter and product industries to help reverse the overall trend of declining life-cycle recycling rates. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Genaidy, A. M.; Sequeira, R.] Univ Cincinnati, Cincinnati, OH 45221 USA.
[Tolaymat, T.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Kohler, J.] US EPA, Off Solid Waste & Emergency Response, Washington, DC 20460 USA.
[Rinder, M.] WorldTek Inc, Cincinnati, OH USA.
RP Genaidy, AM (reprint author), Univ Cincinnati, Cincinnati, OH 45221 USA.
EM world_tek_inc@yahoo.com
NR 88
TC 17
Z9 20
U1 7
U2 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD MAY 1
PY 2009
VL 407
IS 10
BP 3239
EP 3268
DI 10.1016/j.scitotenv.2009.01.025
PG 30
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 437VV
UT WOS:000265515900001
PM 19232675
ER
PT J
AU Richmond-Bryant, J
Saganich, C
Bukiewicz, L
Kalin, R
AF Richmond-Bryant, J.
Saganich, C.
Bukiewicz, L.
Kalin, R.
TI Associations of PM2.5 and black carbon concentrations with traffic,
idling, background pollution, and meteorology during school dismissals
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE PM2.5; Black carbon; Street canyon; Schools; Air quality
ID DIESEL EXHAUST PARTICLES; LARGE-EDDY SIMULATION; NEW-YORK-CITY;
AIR-POLLUTION; STREET CANYON; HUMAN EXPOSURE; URBAN; DISPERSION;
EMISSIONS; RANGE
AB An air quality study was performed outside a cluster of schools in the East Harlem neighborhood of New York City. PM2.5 and black carbon concentrations were monitored using real-time equipment with a one-minute averaging interval. Monitoring was performed at 1:45-3:30 PM during school days over the period October 31-November 17, 2006. The designated time period was chosen to capture vehicle emissions during end-of-day dismissals from the schools. During the monitoring period, minute-by-minute volume counts of idling and passing school buses, diesel trucks, and automobiles were obtained. These data were transcribed into time series of number of diesel vehicles idling, number of gasoline automobiles idling, number of diesel vehicles passing, and number of automobiles passing along the block adjacent to the school cluster. Multivariate regression models of the log-transform of PM2.5 and black carbon (BC) concentrations in the East Harlem street canyon were developed using the observation data and data from the New York State Department of Environmental Conservation on meteorology and background PM2.5. Analysis of variance was used to test the contribution of each covariate to variability in the log-transformed concentrations as a means to judge the relative contribution of each covariate. The models demonstrated that variability in background PM2.5 contributes 80.9% of the variability in log[PM2.5] and 81.5% of the variability in log[BC]. Local traffic Sources were demonstrated to contribute 5.8% of the variability in log[BC] and only 0.43% of the variability in log[PM2.5]. Diesel idling and passing were both significant contributors to variability in log[BC], while diesel passing was a significant contributor to log[PM2.5]. Automobile idling and passing did not contribute significant levels of variability to either concentration. The remainder of variability in each model was explained by temperature, along-canyon wind, and cross-canyon wind, which were all significant in the models. Published by Elsevier B.V.
C1 [Richmond-Bryant, J.] US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA.
[Saganich, C.] Weill Cornell Med Ctr, New York, NY 10065 USA.
[Bukiewicz, L.; Kalin, R.] Asthma Free Sch Zone, New York, NY 10009 USA.
RP Richmond-Bryant, J (reprint author), US EPA, Natl Ctr Environm Assessment, 109 TW Alexander Dr,MD B243-01, Res Triangle Pk, NC 27711 USA.
EM Richmond-bryant.jennifer@epa.gov
RI Wang, Linden/M-6617-2014
FU New York City Department of Transportation [X501.68]
FX The research team kindly acknowledges the New York City Department of
Transportation (Contract No. X501.68) for support of this work. We would
also like to thank Ms. Meglian Valentine, Ms. Loretta Krahling, Ms.
Alinna Sanders, and Mr. Andrew Burgie for their assistance in the field.
NR 34
TC 31
Z9 31
U1 2
U2 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD MAY 1
PY 2009
VL 407
IS 10
BP 3357
EP 3364
DI 10.1016/j.scitotenv.2009.01.046
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 437VV
UT WOS:000265515900013
PM 19250655
ER
PT J
AU DeWitt, JC
Copeland, CB
Luebke, RW
AF DeWitt, Jamie C.
Copeland, Carey B.
Luebke, Robert W.
TI Suppression of Humoral Immunity by Perfluorooctanoic Acid is Independent
of Elevated Serum Corticosterone Concentration in Mice
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE perfluoronated agents; immunotoxicity; corticosterone
ID PEROXISOME PROLIFERATOR; EXOGENOUS CORTICOSTERONE; INDUCED
IMMUNOMODULATION; RESTRAINT STRESS; RESPONSES; EXPOSURE; SYSTEM; CURVE;
AREA; RATS
AB The T-cell-dependent antibody response is suppressed in mice exposed to 3.75, 7.5, 15, and 30 mg PFOA (perfluorooctanoic acid)/kg body weight (bw). Reduced bw accompanied immunosuppression at 15 and 30 mg/kg. We investigated the hypothesis that the observed immunosuppression is secondary to elevated serum corticosterone levels by assessing immune function in adrenalectomized (adx) or sham-operated C57BL/6N female mice exposed to 0, 7.5, or 15 mg PFOA/kg bw in drinking water for 10 days. Bw, primary antibody responses to a T-dependent antigen, clinical serum chemistries related to liver health, and serum corticosterone levels were evaluated. Exposure to 15 mg/kg decreased bw by approximately 10% after 8 days of dosing and until 2 days postdosing in both adx and sham animals; bw of adx animals were still reduced 5 days postdosing. IgM antibody titers were statistically reduced by 15% in sham animals and 18% in adx animals exposed to 15 mg/kg and by 11.8% in adx animals exposed to 7.5 mg/kg. Corticosterone concentrations were elevated by 157% in dosed sham animals relative to control animals and were reduced by 27% in dosed adx animals relative to control animals (neither changes were statistically significant). Clinical serum chemistries related to liver health were not statistically altered by either dose or adrenalectomy. The failure of adrenalectomy to protect mice from the immunosuppressive effects of PFOA indicates that suppression of antibody synthesis is not the result of liver toxicity or stress-related corticosterone production.
C1 [DeWitt, Jamie C.] E Carolina Univ, Dept Pharmacol & Toxicol, Brody Sch Med, Greenville, NC 27834 USA.
[Copeland, Carey B.; Luebke, Robert W.] US EPA, Immunotoxicol Branch, Expt Toxicol Div, NHEERL, Res Triangle Pk, NC 27709 USA.
RP DeWitt, JC (reprint author), E Carolina Univ, Dept Pharmacol & Toxicol, Brody Sch Med, 600 Moye Blvd, Greenville, NC 27834 USA.
EM dewittj@ecu.ecu
OI DeWitt, Jamie/0000-0002-0440-4059
FU University of North Carolina; U.S. Environmental Protection Agency
Cooperative Training Agreement [CT829472]
FX University of North Carolina, U.S. Environmental Protection Agency
Cooperative Training Agreement (CT829472) partially supported J. DeWitt.
NR 21
TC 17
Z9 18
U1 2
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD MAY
PY 2009
VL 109
IS 1
BP 106
EP 112
DI 10.1093/toxsci/kfp040
PG 7
WC Toxicology
SC Toxicology
GA 441AQ
UT WOS:000265742100013
PM 19240040
ER
PT J
AU Evans, MV
Chiu, WA
Okino, MS
Caldwell, JC
AF Evans, M. V.
Chiu, W. A.
Okino, M. S.
Caldwell, J. C.
TI Development of an updated PBPK model for trichloroethylene and
metabolites in mice, and its application to discern the role of
oxidative metabolism in TCE-induced hepatomegaly
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Physiologically-based pharmacokinetic (PBPK) model; TCE; Metabolism;
TCA; DCA; Hepatomegaly
ID MOUSE-LIVER TUMORS; MALE B6C3F1 MOUSE; ALPHA PPAR-ALPHA;
TRICHLOROACETIC-ACID; DICHLOROACETIC ACID; PHARMACOKINETIC MODEL;
SPECIES-DIFFERENCES; CHLORAL HYDRATE; DRINKING-WATER; PEROXISOME
PROLIFERATION
AB Trichloroethylene (TCE) is a lipophilic solvent rapidly absorbed and metabolized via oxidation and conjugation to a variety of metabolites that cause toxicity to several internal targets. Increases in liver weight (hepatomegaly) have been reported to occur quickly in rodents after TCE exposure, with liver tumor induction reported in mice after long-term exposure. An integrated dataset for gavage and inhalation TCE exposure and oral data for exposure to two of its oxidative metabolites (TCA and DCA) was used, in combination with an updated and more accurate physiologically-based pharmacokinetic (PBPK) model, to examine the question as to whether the presence of TCA in the liver is responsible for TCE-induced hepatomegaly in mice. The updated PBPK model was used to help discern the quantitative contribution of metabolites to this effect. The update of the model was based on a detailed evaluation of predictions from previously published models and additional preliminary analyses based on gas uptake inhalation data in mice. The parameters of the updated model were calibrated using Bayesian methods with an expanded pharmacokinetic database consisting of oral, inhalation, and iv studies of TCE administration as well as studies of TCE metabolites in mice. The dose-response relationships for hepatomegaly derived from the multi-study database showed that the proportionality of dose to response for TCE- and DCA-induced hepatomegaly is not observed for administered doses of TCA in the studied range. The updated PBPK model was used to make a quantitative comparison of internal dose of metabolized and administered TCA. While the internal dose of TCA predicted by modeling of TCE exposure (i.e., mg TCA/kg-d) showed a linear relationship with hepatomegaly, the slope of the relationship was much greater than that for directly administered TCA. Thus, the degree of hepatomegaly induced per unit of TCA produced through TCE oxidation is greater than that expected per unit of TCA administered directly, which is inconsistent with the hypothesis that TCA alone accounts for TCE-induced hepatomegaly. In addition, TCE-induced hepatomegaly showed a much more consistent relationship with PBPK model predictions of total oxidative metabolism than with predictions of TCE area-under-the-curve in blood, consistent with toxicity being induced by oxidative metabolites rather than the parent compound. Therefore, these results strongly suggest that oxidative metabolites in addition to TCA are necessary contributors to TCE-induced liver weight changes in mice. Published by Elsevier Inc.
C1 [Evans, M. V.; Chiu, W. A.; Caldwell, J. C.] US EPA, Off Res & Dev, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
[Okino, M. S.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Las Vegas, NV 89193 USA.
RP Evans, MV (reprint author), US EPA, MD B143-01, Res Triangle Pk, NC 27711 USA.
EM evans.marina@epa.gov
NR 95
TC 14
Z9 14
U1 2
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD MAY 1
PY 2009
VL 236
IS 3
BP 329
EP 340
DI 10.1016/j.taap.2009.02.013
PG 12
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 436QQ
UT WOS:000265430100009
PM 19249323
ER
PT J
AU Schwindt, AR
Kent, ML
Ackerman, LK
Simonich, SLM
Landers, DH
Blett, T
Schreck, CB
AF Schwindt, Adam R.
Kent, Michael L.
Ackerman, Luke K.
Simonich, Staci L. Massey
Landers, Dixon H.
Blett, Tamara
Schreck, Carl B.
TI Reproductive Abnormalities in Trout from Western US National Parks
SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY
LA English
DT Article
ID SALMON ONCORHYNCHUS-KISUTCH; HIGH-MOUNTAIN LAKES; COHO SALMON;
ORGANOCHLORINE COMPOUNDS; ORGANIC CONTAMINANTS; ESTROGENIC ACTIVITY;
RAINBOW-TROUT; FISH; DISRUPTION; PESTICIDES
AB Reproductive disruption is well documented in polluted areas, such its below sewage treatment plants, but not in ecologically protected environments, such as national parks. In a majority of subalpine lakes sampled in Rocky Mountain and Glacier National parks. we observed intersex male cutthroat trout oncorhynchus clarkii and brook trout Salvelinus fontinalis at frequencies of 9-33%. Intersexuality, one form of reproductive disruption, is the presence of both male and female reproductive structures in the same animal. Male cutthroat trout, rainbow trout O. mykiss, and brook trout from these parks also produced elevated levels of the estrogen-responsive protein vitellogenin, another indicator of reproductive disruption. We did not find reproductive abnormalities in national parks of the Sierra Nevada, Cascades, Olympics, Brooks, or Alaska ranges. To determine whether gonad abnormalities were evident in mountain ecosystems before the production of organic pollutants, we sampled various species of the family Salmonidae collected from the preorganic pollutant era (pre-1930s). In these museum collections. we observed intersex male greenback cutthroat trout O. clarkii stomias collected in the late 1800s from Twin Lakes, Colorado, in the Rocky Mountains. Our current results suggest that reproductive disruption is occurring in some national parks. The abnormalities were observed in remote. high-elevation locations, suggesting that they might have resulted from airborne contaminants. Our observation of intersex greenback cutthroat trout from the late 1800s suggests that organic pollutants are not the only factors inducing reproductive disruption. The causes and population-level consequences of reproductive disruption in these lakes remain to be determined.
C1 [Schwindt, Adam R.; Kent, Michael L.] Oregon State Univ, Dept Microbiol, Corvallis, OR 97331 USA.
[Ackerman, Luke K.; Simonich, Staci L. Massey] Oregon State Univ, Dept Chem, Corvallis, OR 97331 USA.
[Simonich, Staci L. Massey] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA.
[Landers, Dixon H.] US EPA, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Blett, Tamara] Natl Pk Serv, Air Resources Div, Denver, CO 80225 USA.
[Schreck, Carl B.] US Geol Survey, Oregon Cooperat Fish & Wildlife Res Unit, Corvallis, OR 97331 USA.
[Schreck, Carl B.] Oregon State Univ, Dept Fisheries & Wildlife, Corvallis, OR 97331 USA.
RP Schwindt, AR (reprint author), Denver Museum Nat & Sci, 2001 Colorado Blvd, Denver, CO 80205 USA.
EM ar.schwindt@gmail.com
RI Ackerman, Luke/E-4597-2011
OI Ackerman, Luke/0000-0001-6626-3039
FU National Park Service
FX We thank C. Kennedy and B. Rosenlund (U.S. Fish and Wildlife Service),
D. S. Jordan, the WACAP team, and volunteers from Trout Unlimited for
collecting the fish. We thank G. W. Feist (Department of Fisheries and
Wildlife, Ore,,on State University) for technical support. Patagonia,
Inc. and Marmot Mountain Ltd. are acknowledged for providing outerwear.
We acknowledge the California Academy of Science and the University of
Washington School of Fisheries for use of their fish collections. This
work is part of WACAP. a collaborative venture between the National Park
Service, the U.S. Environmental Protection Agency, the U.S. Geological
Survey, Oregon State University. University of Washington, and the U.S.
Department of Agriculture Forest Service. It was funded primarily
through cooperative and interagency agreements with the National Park
Service and also included in-kind contributions from all of the project
partners. Further information about WACAP can be found at
www.nature.nps.gov/air/Studies/air_toxics/wacap.cfm. This document has
been subjected to appropriate institutional peer review and
administrative review and approved for publication. Approval does not
signify that the contents reflect the views of the U.S. Government, nor
does mention of trade names or commercial products constitute
endorsement or recommendation.
NR 29
TC 14
Z9 14
U1 5
U2 14
PU AMER FISHERIES SOC
PI BETHESDA
PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA
SN 0002-8487
J9 T AM FISH SOC
JI Trans. Am. Fish. Soc.
PD MAY
PY 2009
VL 138
IS 3
BP 522
EP 531
DI 10.1577/T08-006.1
PG 10
WC Fisheries
SC Fisheries
GA 477EJ
UT WOS:000268501100007
ER
PT J
AU Ebersole, JL
Colvin, ME
Wigington, PJ
Leibowitz, SG
Baker, JP
Church, MR
Compton, JE
Miller, BA
Cairns, MA
Hansen, BP
LaVigne, HR
AF Ebersole, Joseph L.
Colvin, Mike E.
Wigington, Parker J., Jr.
Leibowitz, Scott G.
Baker, Joan P.
Church, M. Robbins
Compton, Jana E.
Miller, Bruce A.
Cairns, Michael A.
Hansen, Bruce P.
LaVigne, Henry R.
TI Modeling Stream Network-Scale Variation in Coho Salmon Overwinter
Survival and Smolt Size
SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY
LA English
DT Article
ID TROUT ONCORHYNCHUS-CLARKI; WINTER REARING HABITAT; OREGON COASTAL
STREAMS; LARGE WOODY DEBRIS; ALDER ALNUS-RUBRA; ATLANTIC SALMON;
POPULATION-DYNAMICS; SOUTHEASTERN ALASKA; WASHINGTON STREAMS; RESIDENT
SALMONIDS
AB We used multiple regression and hierarchical mixed-effects models to examine spatial patterns of overwinter survival and size at smolting in juvenile coho salmon Oncorhynchus kisutch in relation to habitat attributes across an extensive stream network in southwestern Oregon over 3 years. Contributing basin area explained the majority of spatial variation (R-2 = 0.57-0.63) in coho salmon overwinter Survival (range 0.02-0.63). with highest survival rates observed in smaller headwater and intermittent streams. Other habitat attributes, including proportional pool area, percent exposed bedrock substrate, percent broadleaf canopy cover, and adult salmon carcass density. were relatively poor predictors Of Survival. Indices of individual fish condition. including fall parr fork length, condition factor, and Parasite infestation tales. were also relatively uninformative in coho salmon overwinter survival models. Cohn salmon smolt length was primarily a function of length at the time of fall tagging. but stream type, contributing basin area (positive effect), thermal history (positive effect), and black spot infestation (i.e.. trematode metacercariae negative effect) were also important, The consistent, broad spatial gradients in overwinter Survival observed in this study can help guide efforts designed to enhance coho salmon production in coastal streams and suggest that habitat protection. restoration. and enhancement strategies will be best guided by a whole-basin context.
C1 [Ebersole, Joseph L.; Wigington, Parker J., Jr.; Leibowitz, Scott G.; Baker, Joan P.; Church, M. Robbins; Compton, Jana E.; Cairns, Michael A.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Colvin, Mike E.] Iowa State Univ, Dept Nat Resource Ecol & Management, Ames, IA 50011 USA.
[Miller, Bruce A.] Oregon Dept Fish & Wildlife, Charleston, OR 97420 USA.
[Hansen, Bruce P.] US Forest Serv, Pacific NW Res Stn, Forestry Sci Lab, Corvallis, OR 97331 USA.
[LaVigne, Henry R.] Dynamac Corp, Corvallis, OR 97333 USA.
RP Ebersole, JL (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA.
EM ebersole.joe@epa.gov
NR 73
TC 10
Z9 10
U1 1
U2 14
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0002-8487
EI 1548-8659
J9 T AM FISH SOC
JI Trans. Am. Fish. Soc.
PD MAY
PY 2009
VL 138
IS 3
BP 564
EP 580
DI 10.1577/T08-047.1
PG 17
WC Fisheries
SC Fisheries
GA 477EJ
UT WOS:000268501100010
ER
PT J
AU Schnaar, G
Digiulio, DC
AF Schnaar, Gregory
Digiulio, Dominic C.
TI Computational Modeling of the Geologic Sequestration of Carbon Dioxide
SO VADOSE ZONE JOURNAL
LA English
DT Article
ID HETEROGENEOUS POROUS-MEDIA; ENHANCED OIL-RECOVERY; DEEP SALINE AQUIFERS;
CO2 STORAGE; REACTIVE TRANSPORT; DISSOLUTION KINETICS;
NUMERICAL-SIMULATION; MULTIPHASE FLOW; GAS-RESERVOIRS; VADOSE ZONE
AB Geologic sequestration of CO(2) is a component of C capture and storage (CCS), an emerging technology for reducing CO(2) emissions to the atmosphere, and involves injection of captured CO(2) into deep subsurface formations. Similar to the injection of hazardous wastes, before injection of CO(2), operators of geologic sequestration projects may need to demonstrate nonendangerment of groundwater resources during the lifetime of the project. Future requirements related to CO(2) accounting and transfer credits may require operators to evaluate and quantify any surface releases. Subsurface fluid flow computational models have been advocated as an integral tool in predicting and tracking the migration on of CO(2) or mobilized constituents. Modeling the injection and sequestration of CO(2) poses unique challenges, such as the need to properly characterize CO(2) transport properties across a large range of temperatures and pressures, and the need to couple multiphase flow, reactive transport, and geomechanical processes. In addition, the volumes of CO(2) that may be injected are largely unprecedented, and an appropriate amount of site characterization across the potentially impacted area will be difficult. In the last several years, there have been several research studies specifically modeling the problem of subsurface injection of CO(2). Existing studies demonstrate the use of modeling in project design, site characterization, assessments of leakage, and site monitoring. Particularly informative components of existing modeling studies include parameter sensitivity analyses, evaluation of numerical artifacts, code comparison, and demonstrations of model calibration to site monitoring data.
C1 [Schnaar, Gregory] US EPA, Off Ground Water & Drinking Water, Washington, DC 20460 USA.
[Digiulio, Dominic C.] US EPA, Robert S Kerr Environm Res Ctr, Off Res & Dev, Natl Risk Management Res Lab,Ground Water & Ecosy, Ada, OK USA.
RP Schnaar, G (reprint author), US EPA, Off Ground Water & Drinking Water, Ariel Rios Bldg,1200 Penn Ave NW, Washington, DC 20460 USA.
EM gschnaar@gmail.com
FU American Association for the Advancement of Science (AAAS) Science and
Technology Policy; U.S. EPA Office of Water
FX The authors would like to thank the American Association for the
Advancement of Science (AAAS) Science and Technology Policy Fellowship
Program and the U.S. EPA Office of Water for support during the
preparation of this publication. In addition, the authors would like to
acknowledge the helpful comments of two anonymous reviewers
NR 84
TC 32
Z9 35
U1 1
U2 19
PU SOIL SCI SOC AMER
PI MADISON
PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA
SN 1539-1663
J9 VADOSE ZONE J
JI Vadose Zone J.
PD MAY
PY 2009
VL 8
IS 2
BP 389
EP 403
DI 10.2136/vzj2008.0112
PG 15
WC Environmental Sciences; Soil Science; Water Resources
SC Environmental Sciences & Ecology; Agriculture; Water Resources
GA 448YE
UT WOS:000266297100012
ER
PT J
AU Yau, V
Wade, TJ
de Wilde, CK
Colford, JM
AF Yau, Vincent
Wade, Timothy J.
de Wilde, Carol K.
Colford, John M., Jr.
TI Skin-related symptoms following exposure to recreational water: a
systematic review and meta-analysis
SO WATER QUALITY EXPOSURE AND HEALTH
LA English
DT Article
DE Recreational water; Bacterial indicators; Rash; Skin disease; Marine
water; Fresh water
AB Exposure to contaminated recreational waters (defined by levels of fecal and other types of indicator bacteria) is associated with adverse health outcomes. The principal health outcome studied previously has been gastrointestinal illness. Although many studies included reports of frequent skin complaints (e. g. rash or itch) following recreational water exposure, no systematic reviews have examined the association between indicator levels and skin-related symptoms. Twenty relevant peer-reviewed studies were identified. The relative risks (swimmers vs. nonswimmers) of skin-related symptoms among those exposed to recreational water with bacterial indicator concentrations above threshold levels were determined using meta-analysis. Similarly, the relative risks (swimmers vs. non-swimmers) of skin-related complaints after exposure to water with bacterial indicator concentrations below threshold levels were determined. The ratio of these odds ratios (ROR) was then computed for each indicator. The risk of skin-related symptoms was significantly elevated in marine water with high levels of total coliforms ROR 1.86, (95% CI 1.21, 2.87); fecal coliforms ROR 1.45 (95% CI 1.02, 2.07); E. coli ROR 1.98, (95% CI 1.43, 2.75); enterococci ROR 2.04 (95% CI 1.34, 3.09) and fecal streptococci ROR 1.70 (95% CI 1.07, 2.71). However, no significant associations with water quality indicators were demonstrated for the freshwater indicators examined (total coliform, fecal coliform, E. coli). Swimmers exposed to marine water at high levels of several indicator bacteria experience a significant increase in skin-related symptoms compared to non-swimmers. This relationship was not demonstrated in freshwater settings.
C1 [Yau, Vincent; de Wilde, Carol K.; Colford, John M., Jr.] Univ Calif Berkeley, Sch Publ Hlth, Dept Epidemiol, Berkeley, CA 94720 USA.
[Wade, Timothy J.] US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
RP Yau, V (reprint author), Univ Calif Berkeley, Sch Publ Hlth, Dept Epidemiol, Berkeley, CA 94720 USA.
EM vincentmyau@gmail.com
NR 58
TC 10
Z9 10
U1 1
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1876-1658
EI 1876-1666
J9 WATER QUAL EXPOS HEA
JI Water Qual. Expos. Health
PD MAY
PY 2009
VL 1
IS 2
BP 79
EP 103
DI 10.1007/s12403-009-0012-9
PG 25
WC Water Resources
SC Water Resources
GA V35HB
UT WOS:000209139900002
ER
PT J
AU Pham, TTH
Brar, SK
Tyagi, RD
Surampalli, RY
AF Pham, T. T. H.
Brar, Satinder K.
Tyagi, R. D.
Surampalli, R. Y.
TI Ultrasonication of wastewater sludge-Consequences on biodegradability
and flowability
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Wastewater sludge; Ultrasonication; Biodegradability; Flowability;
Response surface method
ID EXTRACELLULAR POLYMERIC SUBSTANCES; ACTIVATED-SLUDGE; PRETREATMENT;
DISINTEGRATION
AB The present Study deals with pre-treatment of wastewater sludge by ultrasonic waves at frequency of 20 kHz using fully automated lab-scale ultrasonication equipment. Different wastewater sludge solids concentrations, ultrasonication intensities, and exposure times of pre-treatment were investigated for the optimization of ultrasonication treatment process. The parameters of pre-treatment process were optimized by using response surface methodology. A 21 central composite design was performed for optimization. The screening experiment step comprised steepest ascent methodology to determine optimal domain, The effect of ultrasonication treatment was assessed in terms of increase in soluble solids and the biodegradability of the wastewater sludge. In addition, theological parameter of wastewater sludge, namely, viscosity was also measured to ascertain the Suitability of wastewater sludge for conventional treatment processes as well as submerged fermentation, a major step for the production of value-added products from sludge. It was observed that the ultrasonication intensity and pre-treatment exposure time significantly affected the efficiency of the ultrasonication process followed by the solids concentration. The optimal conditions of ultrasonic pre-treatment were 0.75 W/cm(2) ultrasonication intensity, 60 min, and 23 g/L total solids concentration, The increases in soluble chemical oxygen demand and biodegradability, by aerobic sludge digestion process, in terms of total solids consumption increased by 45.5% and 56%, respectively, The flowability Of ultrasonicated sludge in terms of viscosity showed exponential behaviour at different total solids concentrations, and pseudoplastic and thixotropic behaviour similar to raw sludge. Nevertheless, the magnitude of viscosity values of ultrasonicated sludge was always lower than the raw sludge. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Pham, T. T. H.; Brar, Satinder K.; Tyagi, R. D.] Univ Quebec, INRS ETE, Quebec City, PQ G1K 9A9, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP Tyagi, RD (reprint author), Univ Quebec, INRS ETE, 490 Rue Couronne, Quebec City, PQ G1K 9A9, Canada.
EM tyagi@ete.inrs.ca
FU Natural Sciences and Engineering Research Council of Canada [A4984,
STP235071]; Canada Research Chair; NSERC(DG); INRS-ETE
FX The authors are sincerely thankful to the Natural Sciences and
Engineering Research Council of Canada (Grants A4984, STP235071, Canada
Research Chair), NSERC(DG) and INRS-ETE for financial support. We are
thankful to Dr. Simon Barnabe for providing valuable and inciting
support during the analysis of results using surface response
methodology. The views or opinions expressed in this article are those
of the authors and should not be construed as opinions of the U.S.
Environmental Protection Agency.
NR 21
TC 38
Z9 39
U1 3
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD APR 30
PY 2009
VL 163
IS 2-3
BP 891
EP 898
DI 10.1016/j.jhazmat.2008.07.091
PG 8
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 418PH
UT WOS:000264160000055
PM 18768255
ER
PT J
AU Hansen, CA
Barnett, AG
Jalaludin, BB
Morgan, GG
AF Hansen, Craig A.
Barnett, Adrian G.
Jalaludin, Bin B.
Morgan, Geoffrey G.
TI Ambient Air Pollution and Birth Defects in Brisbane, Australia
SO PLOS ONE
LA English
DT Article
AB Background: Birth defects are a major public health concern as they are the leading cause of neonatal and infant mortality. Observational studies have linked environmental pollution to adverse birth outcomes, including congenital anomalies. This study examined potential associations between ambient air pollution and congenital heart defects and cleft lip or palate among births in Brisbane, Australia (1998-2004).
Methods: Ambient air pollution levels were averaged over weeks 3-8 of pregnancy among 150,308 births. Using a case control design, we used conditional logistic regression and matched cases to 5 controls. Analyses were conducted using all births, and then births where the mother resided within 6 and 12 kilometers of an ambient air quality monitor.
Findings: When analyzing all births there was no indication that ambient air pollution in Brisbane was associated with a higher risk of cardiac defects. Among births where the mother resided within 6 kilometers of an ambient air quality monitor, a 5 ppb increase in O(3) was associated with an increased risk of pulmonary artery and valve defects (OR 2.96, 95% CI: 1.34, 7.52) while a 0.6 ppb increase in SO(2) was associated with an increased risk of aortic artery and valve defects (OR 10.76, 95% CI: 1.50, 179.8). For oral cleft defects among all births, the only adverse association was between SO2 and cleft lip with or without cleft palate (OR 1.27, 95% CI: 1.01, 1.62). However, various significant inverse associations were also found between air pollutants and birth defects.
Conclusions: This study found mixed results and it is difficult to conclude whether ambient air pollution in Brisbane has an adverse association with the birth defects examined. Studies using more detailed estimates of air pollution exposure are needed.
RP Hansen, CA (reprint author), US EPA, Natl Ctr Environm Assessment, Durham, NC USA.
EM a.barnett@qut.edu.au
RI Hansen, Craig /C-7543-2014; Alejandro Martin, Serguei/A-6593-2012;
OI Hansen, Craig /0000-0002-5227-0155; Barnett, Adrian/0000-0001-6339-0374
NR 46
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U1 1
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 30
PY 2009
VL 4
IS 4
AR e5408
DI 10.1371/journal.pone.0005408
PG 8
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 439GF
UT WOS:000265614900019
PM 19404385
ER
PT J
AU Lewis, JA
Szilagyi, M
Gehman, E
Dennis, WE
Jackson, DA
AF Lewis, John A.
Szilagyi, Maria
Gehman, Elizabeth
Dennis, William E.
Jackson, David A.
TI Distinct patterns of gene and protein expression elicited by
organophosphorus pesticides in Caenorhabditis elegans
SO BMC GENOMICS
LA English
DT Article
ID LIFE-SPAN; C-ELEGANS; INTERMEDIATE-FILAMENT; DIETARY RESTRICTION; STRESS
RESISTANCE; CULTURE METHODS; IN-VITRO; NEMATODE; GROWTH; MECHANISM
AB Background: The wide use of organophosphorus (OP) pesticides makes them an important public health concern. Persistent effects of exposure and the mechanism of neuronal degeneration are continuing issues in OP toxicology. To elucidate early steps in the mechanisms of OP toxicity, we studied alterations in global gene and protein expression in Caenorhabditis elegans exposed to OPs using microarrays and mass spectrometry. We tested two structurally distinct OPs (dichlorvos and fenamiphos) and employed a mechanistically different third neurotoxicant, mefloquine, as an out-group for analysis. Treatment levels used concentrations of chemical sufficient to prevent the development of 10%, 50% or 90% of mid-vulval L4 larvae into early gravid adults (EGA) at 24 h after exposure in a defined, bacteria-free medium.
Results: After 8 h of exposure, the expression of 87 genes responded specifically to OP treatment. The abundance of 34 proteins also changed in OP-exposed worms. Many of the genes and proteins affected by the OPs are expressed in neuronal and muscle tissues and are involved in lipid metabolism, cell adhesion, apoptosis/cell death, and detoxification. Twenty-two genes were differentially affected by the two OPs; a large proportion of these genes encode cytochrome P450s, UDP-glucuronosyl/UDP-glucosyltransferases, or P-glycoproteins. The abundance of transcripts and the proteins they encode were well correlated.
Conclusion: Exposure to OPs elicits a pattern of changes in gene expression in exposed worms distinct from that of the unrelated neurotoxicant, mefloquine. The functional roles and the tissue location of the genes and proteins whose expression is modulated in response to exposure is consistent with the known effects of OPs, including damage to muscle due to persistent hypercontraction, neuronal cell death, and phase I and phase II detoxification. Further, the two different OPs evoked distinguishable changes in gene expression; about half the differences are in genes involved in detoxification, likely reflecting differences in the chemical structure of the two OPs. Changes in the expression of a number of sequences of unknown function were also discovered, and these molecules could provide insight into novel mechanisms of OP toxicity or adaptation in future studies.
C1 [Lewis, John A.; Dennis, William E.; Jackson, David A.] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA.
[Szilagyi, Maria] US EPA, Washington, DC 20460 USA.
[Gehman, Elizabeth] Battelle Natl Biodef Inst, Frederick, MD USA.
RP Lewis, JA (reprint author), USA, Ctr Environm Hlth Res, Ft Detrick, MD USA.
EM john.a.lewis1@us.army.mil; Szilagyi.Maria@epamail.epa.gov;
gehmane@nbacc.net; william.e.dennis@us.army.mil;
david.a.jackson2@us.army.mil
RI Jackson, David/E-9984-2014
FU U.S. Army Medical Research and Materiel Command, Military Operational
Medicine Research Program
FX Opinions, interpretations, conclusions, and recommendations are those of
the authors and are not necessarily endorsed by the U. S. Army or the U.
S. Environmental Protection Agency. The research was sponsored by the
U.S. Army Medical Research and Materiel Command, Military Operational
Medicine Research Program. Citations of commercial organizations or
trade names in this report do not constitute an official Department of
the Army endorsement or approval of the products or services of these
organizations. The authors wish to thank Dr. Marianne Vahey and staff at
the Walter Reed Army Institute of Research Vaccine Genomics Laboratory
for their gracious and exemplary support in microarray processing and
Alan Rosencrance for analysis of chemical concentrations. We also thank
Dr. James F. Dillman for critical review of the manuscript.
NR 85
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U1 1
U2 17
PU BIOMED CENTRAL LTD
PI LONDON
PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T
4LB, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD APR 29
PY 2009
VL 10
AR 202
DI 10.1186/1471-2164-10-202
PG 21
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 456PL
UT WOS:000266859200001
PM 19402892
ER
PT J
AU Wilson, VS
Lambright, CR
Furr, JR
Howdeshell, KL
Gray, LE
AF Wilson, Vickie S.
Lambright, Christy R.
Furr, Johnathan R.
Howdeshell, Kembra L.
Gray, L. Earl, Jr.
TI The herbicide linuron reduces testosterone production from the fetal rat
testis during both in utero and in vitro exposures
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Linuron; Testosterone production; Sex differentiation; Endocrine
disruption; Fetal; Rat
ID ALTERS SEXUAL-DIFFERENTIATION; ANDROGEN-RECEPTOR ANTAGONIST;
REPRODUCTIVE MALFORMATIONS; DIETHYLHEXYL PHTHALATE; DI(N-BUTYL)
PHTHALATE; ANOGENITAL DISTANCE; NIPPLE RETENTION; GENE-EXPRESSION;
PROCYMIDONE; PROFILES
AB In utero exposure to linuron, an urea-based herbicide, results in a pattern of malformations of androgen-dependent tissues in adult male rat offspring resembling that produced by some phthalate esters which are known to decrease fetal testosterone production. This study investigated the impact of in utero linuron treatment on fetal testis gene expression and testosterone production. Timed-pregnant Sprague Dawley rats were administered corn oil vehicle, 12.5, 25, 50 or 75 mg linuron/day/kg orally from GD13 to 18. Ex vivo testosterone (T) production was significantly decreased at 50 and 75 mg/kg when analyzed on a per litter basis. Unlike the phthalate esters, linuron treatment did not affect ins13, cyp17a, cyp11a or StAR mRNA expression. Control GD18 fetal testes were then incubated with increasing concentrations of linuron (1-300 mu M) to evaluate if linuron inhibited T production in vitro. T production was significantly reduced at 30 mu M and above. Progesterone production was not affected in any of the studies indicating that linuron directly inhibited testosterone production in the absence of cytotoxicity. These results indicate the malformations induced by linuron and phthalate esters in male offspring are similar because both reduce fetal T levels during the critical period of sex differentiation but suggest that the mechanisms differ. Published by Elsevier Ireland Ltd.
C1 [Wilson, Vickie S.] US EPA, NHEERL, RTD MD 72, Off Res & Dev,Reprod Toxicol Div, Res Triangle Pk, NC 27711 USA.
RP Wilson, VS (reprint author), US EPA, NHEERL, RTD MD 72, Off Res & Dev,Reprod Toxicol Div, 2525 E Highway 54, Res Triangle Pk, NC 27711 USA.
EM wilson.vickie@epa.gov
NR 22
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U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0378-4274
J9 TOXICOL LETT
JI Toxicol. Lett.
PD APR 25
PY 2009
VL 186
IS 2
BP 73
EP 77
DI 10.1016/j.toxiet.2008.12.017
PG 5
WC Toxicology
SC Toxicology
GA 430GI
UT WOS:000264976400001
PM 19167474
ER
PT J
AU Bullock, OR
Atkinson, D
Braverman, T
Civerolo, K
Dastoor, A
Davignon, D
Ku, JY
Lohman, K
Myers, TC
Park, RJ
Seigneur, C
Selin, NE
Sistla, G
Vijayaraghavan, K
AF Bullock, O. Russell, Jr.
Atkinson, Dwight
Braverman, Thomas
Civerolo, Kevin
Dastoor, Ashu
Davignon, Didier
Ku, Jia-Yeong
Lohman, Kristen
Myers, Thomas C.
Park, Rokjin J.
Seigneur, Christian
Selin, Noelle E.
Sistla, Gopal
Vijayaraghavan, Krish
TI An analysis of simulated wet deposition of mercury from the North
American Mercury Model Intercomparison Study
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
ID ATMOSPHERIC MERCURY
AB A previous intercomparison of atmospheric mercury models in North America has been extended to compare simulated and observed wet deposition of mercury. Three regional-scale atmospheric mercury models were tested: the Community Multiscale Air Quality (CMAQ) model, the Regional Modeling System for Aerosols and Deposition (REMSAD), and the Trace Element Analysis Model (TEAM). These models were each employed using three sets of lateral boundary conditions to test their sensitivity to intercontinental transport of mercury. The same meteorological and pollutant emission data were used in each simulation. Observations of wet deposition were obtained from the National Atmospheric Deposition Program's Mercury Deposition Network. The regional models can explain 50-70% of the site-to-site variance in annual mercury wet deposition. CMAQ was found to have slightly superior agreement with observations of annual mercury deposition flux in terms of the mean value for all monitoring sites, but REMSAD showed the best correlation when measured by the coefficient of determination (r(2)). With the exception of one CMAQ simulation, all of the models tended to simulate more wet deposition of mercury than was observed. TEAM exceeded the observed average annual wet deposition by 50% or more in all three of its simulations. CMAQ and REMSAD were better able to reproduce the observed seasonal distribution of mercury wet deposition than was TEAM, but TEAM showed the highest correlation for weekly wet deposition samples. An analysis of model accuracy at each observation site showed no obvious geographic patterns for correlation, bias, or error. Adjusting simulated mercury deposition on the basis of the difference between observed and simulated precipitation data improved the correlation and error scores for all of the models.
C1 [Bullock, O. Russell, Jr.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Atkinson, Dwight] US EPA, Off Water, Washington, DC 20460 USA.
[Braverman, Thomas] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Civerolo, Kevin; Ku, Jia-Yeong; Sistla, Gopal] New York State Dept Environm Conservat, Albany, NY 12233 USA.
[Dastoor, Ashu; Davignon, Didier] Environm Canada, Air Qual Res Div, Dorval, PQ H9P 1J3, Canada.
[Lohman, Kristen; Seigneur, Christian; Vijayaraghavan, Krish] Atmospher & Environm Res Inc, San Ramon, CA 94583 USA.
[Myers, Thomas C.] ICF Int, San Rafael, CA 94903 USA.
[Park, Rokjin J.] Seoul Natl Univ, Sch Earth & Environm Sci, Seoul 151747, South Korea.
[Selin, Noelle E.] MIT, Dept Earth Atmospher & Planetary Sci, Cambridge, MA 02139 USA.
RP Bullock, OR (reprint author), US EPA, Natl Exposure Res Lab, Mail Drop E243-03, Res Triangle Pk, NC 27711 USA.
EM bullock.russell@epa.gov
RI Selin, Noelle/A-4158-2008; Park, Rokjin/I-5055-2012;
OI Selin, Noelle/0000-0002-6396-5622; Park, Rokjin/0000-0001-8922-0234;
Civerolo, Kevin/0000-0003-1536-2664
FU The United States Environmental Protection Agency through its Office of
Research and Development
FX The United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research described here.
It has been subjected to the Agency's administrative review and approved
for publication. The work presented here does not necessarily reflect
the policies or views of the other participating agencies.
NR 13
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U1 1
U2 15
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD APR 18
PY 2009
VL 114
AR D08301
DI 10.1029/2008JD011224
PG 12
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 435FO
UT WOS:000265329500003
ER
PT J
AU Friedman, CL
Burgess, RM
Perron, MM
Cantwell, MG
Ho, KT
Lohmann, R
AF Friedman, Carey L.
Burgess, Robert M.
Perron, Monique M.
Cantwell, Mark G.
Ho, Kay T.
Lohmann, Rainer
TI Comparing Polychaete and Polyethylene Uptake to Assess Sediment
Resuspension Effects on PCB Bioavailability
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID SEMIPERMEABLE-MEMBRANE DEVICES; POLYCYCLIC AROMATIC-HYDROCARBONS;
ORGANIC CONTAMINANT DISTRIBUTION; WATER PARTITION-COEFFICIENTS;
POLYCHLORINATED BIPHENYL; BLACK CARBON; PORE-WATER; ESTUARINE SEDIMENTS;
PASSIVE SAMPLERS; BIOACCUMULATION
AB Polyethylene sampler uptake was compared to polychaete uptake to assess bioavailability of polychlorinated biphenyls (PCBs) from resuspended sediments. New Bedford Harbor (MA, U.S.) sediment, contaminated with PCBs, was resuspended under four different water column oxidation conditions: resuspension alone, resuspension under aeration, resuspension under helium, and no resuspension (control). Residuals were tested for differences in PCB availability to the marine polychaete Nereis virens and to polyethylene (PE) passive samplers. Few significant differences between the four resuspension treatments were observed: under aeration, three of 23 PCBs analyzed showed significant increases in polychaete accumulation, while resuspension alone showed increased concentrations in PE samplers for nine of 23 PCBs. Otherwise, no differences were observed and overall we concluded that resuspension had no effect on residual PCB availability. The relationship between disequilibrium-corrected PE and lipid-normalized polychaete PCB concentrations was nearly 1:1 with a strong linear correlation (r(2) = 0.877), demonstrating PCBs are taken up similarly into PE and lipid. On average, PE samplers suggested dissolved PCB concentrations 3.6 times greater than those calculated with lipid-water partitioning, though on a congener-specific basis this was only observed for lower chlorinated PCBs; for higher chlorinated PCBs, PE-water partitioning suggested lower dissolved concentrations than those based on lipid. Organic carbon (OC)-water and OC and black carbon combined (OC+BC)-water partitioning suggested average dissolved concentrations 29 and 10 times greater, respectively, than those estimated with lipid-water partitioning. This demonstrates that PE-measured porewater concentrations can provide a more reliable estimate of bioavailability than sediment geochemistry.
C1 [Friedman, Carey L.; Lohmann, Rainer] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA.
[Burgess, Robert M.; Perron, Monique M.; Cantwell, Mark G.; Ho, Kay T.] US EPA, ORD NHEERL, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Burgess, Robert M.; Perron, Monique M.; Cantwell, Mark G.; Ho, Kay T.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
RP Friedman, CL (reprint author), Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA.
EM cfriedman@gso.uri.edu
RI Lohmann, Rainer/B-1511-2008;
OI Lohmann, Rainer/0000-0001-8796-3229
FU U.S. EPA [EP06D000527]
FX We acknowledge Stephan A. Ryba and Richard A. McKinney (U.S. EPA) for
assistance with this Study. This work was supported in part by a student
services contract from the U.S. EPA (No. EP06D000527).
NR 43
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U2 38
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD APR 15
PY 2009
VL 43
IS 8
BP 2865
EP 2870
DI 10.1021/es803695n
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 432ZK
UT WOS:000265172800035
PM 19475963
ER
PT J
AU Wilkin, RT
Acree, SD
Ross, RR
Beak, DG
Lee, TR
AF Wilkin, Richard T.
Acree, Steven D.
Ross, Randall R.
Beak, Douglas G.
Lee, Tony R.
TI Performance of a zerovalent iron reactive barrier for the treatment of
arsenic in groundwater: Part 1. Hydrogeochemical studies
SO JOURNAL OF CONTAMINANT HYDROLOGY
LA English
DT Article
DE Permeable reactive barrier; Zerovalent iron; Arsenic; Contaminant flux
ID ZERO-VALENT IRON; REMOVAL; REMEDIATION; WATER; FIELD; PHOSPHATE;
SILICATE; KINETICS; AQUIFERS; MEDIA
AB Developments and improvements of remedial technologies are needed to effectively manage arsenic contamination in groundwater at hazardous waste sites. In June 2005, a 9.1 mlong, 14m deep, and 1.8 to 2.4 m wide (in the direction of groundwater flow) pilot-scale permeable reactive barrier (PRB) was installed at a former lead smelting facility, located near Helena, Montana (USA). The reactive barrier was designed to treat groundwater contaminated with moderately high concentrations of both As(III) and As(V). The reactive barrier was installed over a 3-day period using bio-polymer slurry methods and modified excavating equipment for deep trenching. The reactive medium was composed entirely of granular iron which was selected based on long-term laboratory column experiments. A monitoring network of approximately 40 groundwater sampling points was installed in July 2005. Monitoring results indicate arsenic concentrations >25 mg L(-1) in wells located hydraulically upgradient of the PRB. Of 80 groundwater samples collected from the pilot-PRB, 11 samples exceeded 0.50 mg As L(-1); 62 samples had concentrations of arsenic at or below 0.50 ring L(-1); and, 24 samples were at or below the maximum contaminant level (MCL) for arsenic of 0.01 mg L(-1). After 2 years of operation, monitoring points located within 1 m of the downgradient edge of the PRB showed significant decreases in arsenic concentrations at depth intervals impacted by the emplaced zerovalent iron. This study indicates that zerovalent iron can be effectively used to treat groundwater contaminated with arsenic given appropriate groundwater geochemistry and hydrology. The study also further demonstrates the shortcomings of hanging-wall designs. Detailed subsurface characterization data that capture geochemical and hydrogeologic variability, including a flux-based analysis, are needed for successful applications of PRB technology for arsenic remediation. Published by Elsevier B.V.
C1 [Wilkin, Richard T.; Acree, Steven D.; Ross, Randall R.; Beak, Douglas G.; Lee, Tony R.] US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, Ada, OK 74820 USA.
RP Wilkin, RT (reprint author), US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, 919 Kerr Res Dr, Ada, OK 74820 USA.
EM wilkin.rick@epa.gov
RI Beak, Douglas/F-1846-2010
FU Shaw Environmental, Inc [68-C-03-097]; ASARCO, Inc [278-03]; USEPA
FX The U. S. Environmental Protection Agency through its Office of Research
and Development funded the research described here. It has not been
subjected to Agency review and therefore does not necessarily reflect
the views of the Agency, and no official endorsement should be inferred.
Mention of trade names or commercial products does not constitute
endorsement or recommendation for use. We gratefully acknowledge the
research support provided by Shaw Environmental, Inc. (Contract
#68-C-03-097). Research described in this report was partially funded by
a Cooperative Research and Development Agreement (CRADA, 278-03) between
ASARCO, Inc. and the USEPA We thank Cindy Paul Mary Sue McNeil, Pat
Clark, Ken Jewell, Chunming Su, Michael Brooks, Frank Beck, Brad
Scroggins (USEPA), Hsing-Lung Lien (National University of Kaohsiung,
Taiwan), and Joanne Smieja (Gonzaga University) for help in the field
and lab.
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-7722
J9 J CONTAM HYDROL
JI J. Contam. Hydrol.
PD APR 15
PY 2009
VL 106
IS 1-2
BP 1
EP 14
DI 10.1016/j.jconhyd.2008.12.002
PG 14
WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources
SC Environmental Sciences & Ecology; Geology; Water Resources
GA 435BZ
UT WOS:000265319600001
PM 19167133
ER
PT J
AU Beak, DG
Wilkin, RT
AF Beak, Douglas G.
Wilkin, Richard T.
TI Performance of a zerovalent iron reactive barrier for the treatment of
arsenic in groundwater: Part 2. Geochemical modeling and solid phase
studies
SO JOURNAL OF CONTAMINANT HYDROLOGY
LA English
DT Article
DE Permeable reactive barrier; Zerovalent iron; Arsenic; Thioarsenic; XANES
ID ZERO-VALENT IRON; RAY-ABSORPTION SPECTROSCOPY; CORROSION PRODUCTS;
COLUMN TESTS; REMOVAL; SOLUBILITY; SPECIATION; WATER; 90-DEGREES-C;
REMEDIATION
AB Arsenic uptake processes were evaluated in a zerovalent iron reactive barrier installed at a lead smelting facility using geochemical modeling, solid-phase analysis, and X-ray absorption spectroscopy techniques. Aqueous speciation of arsenic is expected to play a key role in directing arsenic uptake processes. Geochemical modeling reveals contrasting pH-dependencies for As(III) and As(V) precipitation. At the moderately alkaline pH conditions typically encountered in zerovalent iron reactive barriers, As(III) is unlikely to precipitate as an oxide or a sulfide phase. Conversely, increasing pH is expected to drive precipitation of metal arsenates including ferrous arsenate. Bacterially mediated sulfate reduction plays an important role in field installations of granular iron. Neoformed iron sulfides provide surfaces for adsorption of oxyanion and thioarsenic species of As(III) and As(V) and are expected to provide enhanced arsenic removal capacity. X-ray absorption near edge structure (XANES) spectra indicate that arsenic is sequestered in the solid phase as both As(III) and As(V) in coordination environments with 0 and S. Arsenic removal in the PRB probably results from several pathways, including adsorption to iron oxide and iron sulfide surfaces, and possible precipitation of ferrous arsenate. Corrosion of granular iron appears to result in some As(III) oxidation to As(V) as the proportion of As(V) to As(III) in the solid phase is greater compared to influent groundwater. As(0) was not detected in the PRB materials. These results are broadly comparable to laboratory based studies of arsenic removal by zerovalent iron, but additional complexity is revealed in the field environment, which is largely due to the influence of subsurface microbiota. Published by Elsevier B.V.
C1 [Beak, Douglas G.; Wilkin, Richard T.] US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, Ada, OK 74820 USA.
RP Wilkin, RT (reprint author), US EPA, Natl Risk Management Res Lab, Ground Water & Ecosyst Restorat Div, 919 Kerr Res Dr, Ada, OK 74820 USA.
EM wilkin.rick@epa.gov
RI Beak, Douglas/F-1846-2010
FU Shaw Environmental [68-C-03-097]; ASARCO, Inc [278-03]; U. S. Department
of Energy; Office of Science; Office of Basic Energy Sciences
[DE-AC02-06CH11357]; E.I. Dupont de Nemours Co; Dow Chemical Company;
State of Illinois
FX The U. S. Environmental Protection Agency through its Office of Research
and Development funded the research described here. It has not been
subjected to Agency review and therefore does not necessarily reflect
the views of the Agency, and no official endorsement should be inferred.
Mention of trade names or commercial products does not constitute
endorsement or recommedation for use. We gratefully acknowledge the
analytical support provided by Shaw Environmental (Contract
#68-C-03-097), especially Steve Markham for conducting arsenic
speciation analyses. We thank Brad Scroggins and Ken Jewell (USEPA) for
help in collecting core samples and Tony Lee (USEPA) for help with the
SEM analysis. Research described in this paper was partially funded by a
Cooperative Research and Development Agreement (CRADA, 278-03) between
ASARCO, Inc. and the USEPA Use of the Advanced Photon Source was
supported by the U. S. Department of Energy, Office of Science, Office
of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357. The
authors greatly appreciate support provided by the staff of the
Dow-Northwestern-DuPont Collaborative Access Team and the Pacific
Northwest Consortium Collaborative Access Team at Argonne National
Laboratory. PNC-XOR facilities at the Advanced Photon Source, and
research at these facilities, are supported by the US DOE Basic Energy
Science, a major facilities access grant from NSERC, the University of
Washington, Simon Fraser University and the Advanced Photon Source.
DND-CAT is supported by E.I. Dupont de Nemours & Co., the Dow Chemical
Company and the State of Illinois.
NR 47
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U2 29
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-7722
J9 J CONTAM HYDROL
JI J. Contam. Hydrol.
PD APR 15
PY 2009
VL 106
IS 1-2
BP 15
EP 28
DI 10.1016/j.jconhyd.2008.12.003
PG 14
WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources
SC Environmental Sciences & Ecology; Geology; Water Resources
GA 435BZ
UT WOS:000265319600002
PM 19167132
ER
PT J
AU Royland, JE
Kodavanti, PRS
AF Royland, Joycc E.
Kodavanti, Prasada Rao S.
TI Response to comment on "Toxicogenomics in human health risk assessment"
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Letter
ID GENE-EXPRESSION PROFILES; POLYCHLORINATED-BIPHENYLS PCBS; POSSIBLE
MODE(S); EXPOSURE; AROCLOR-1254; CEREBELLUM; SCHIZOPHRENIA;
NEUROTOXICITY; MIGRATION; CULTURES
C1 [Royland, Joycc E.; Kodavanti, Prasada Rao S.] US EPA, Div Neurotoxicol, Res Triangle Pk, NC 27711 USA.
RP Kodavanti, PRS (reprint author), US EPA, Div Neurotoxicol, B105-06, Res Triangle Pk, NC 27711 USA.
EM kodavanti.prasada@epa.gov
NR 25
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U1 1
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD APR 15
PY 2009
VL 236
IS 2
BP 257
EP 260
DI 10.1016/j.taap.2009.01.020
PG 4
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 429XV
UT WOS:000264954300014
ER
PT J
AU Boon, K
Bailey, NW
Yang, J
Steel, MP
Groshong, S
Kervitsky, D
Brown, KK
Schwarz, MI
Schwartz, DA
AF Boon, Kathy
Bailey, Nathaniel W.
Yang, Jun
Steel, Mark P.
Groshong, Steve
Kervitsky, Dolly
Brown, Kevin K.
Schwarz, Marvin I.
Schwartz, David A.
TI Molecular Phenotypes Distinguish Patients with Relatively Stable from
Progressive Idiopathic Pulmonary Fibrosis (IPF)
SO PLOS ONE
LA English
DT Article
AB Background: Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic interstitial lung disease that is unresponsive to current therapy and often leads to death. However, the rate of disease progression differs among patients. We hypothesized that comparing the gene expression profiles between patients with stable disease and those in which the disease progressed rapidly will lead to biomarker discovery and contribute to the understanding of disease pathogenesis.
Methodology and Principal Findings: To begin to address this hypothesis, we applied Serial Analysis of Gene Expression (SAGE) to generate lung expression profiles from diagnostic surgical lung biopsies in 6 individuals with relatively stable (or slowly progressive) IPF and 6 individuals with progressive IPF (based on changes in DLCO and FVC over 12 months). Our results indicate that this comprehensive lung IPF SAGE transcriptome is distinct from normal lung tissue and other chronic lung diseases. To identify candidate markers of disease progression, we compared the IPF SAGE profiles in stable and progressive disease, and identified a set of 102 transcripts that were at least 5-fold up regulated and a set of 89 transcripts that were at least 5-fold down regulated in the progressive group (P-value <= 0.05). The over expressed genes included surfactant protein A1, two members of the MAPK-EGR-1-HSP70 pathway that regulate cigarette-smoke induced inflammation, and Plunc (palate, lung and nasal epithelium associated), a gene not previously implicated in IPF. Interestingly, 26 of the up regulated genes are also increased in lung adenocarcinomas and have low or no expression in normal lung tissue. More importantly, we defined a SAGE molecular expression signature of 134 transcripts that sufficiently distinguished relatively stable from progressive IPF.
Conclusions: These findings indicate that molecular signatures from lung parenchyma at the time of diagnosis could prove helpful in predicting the likelihood of disease progression or possibly understanding the biological activity of IPF.
C1 NHLBI, Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
Duke Univ, Med Ctr, Durham, NC 27706 USA.
Natl Jewish Hlth, Denver, CO USA.
Univ Colorado, Hlth Sci Ctr, Denver, CO USA.
RP Boon, K (reprint author), NHLBI, Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
EM Kathy.Boon@gmail.com
FU National Heart, Lung, and Blood Institute; National Institute of
Environmental Health Sciences
FX This research was supported by the intramural research programs at the
National Heart, Lung, and Blood Institute, and the National Institute of
Environmental Health Sciences. The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of
manuscript.
NR 55
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U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 6
PY 2009
VL 4
IS 4
AR e5134
DI 10.1371/journal.pone.0005134
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 437RS
UT WOS:000265505200007
PM 19347046
ER
PT J
AU Basso, O
Wilcox, AJ
AF Basso, Olga
Wilcox, Allen J.
TI Intersecting Birth Weight-specific Mortality Curves: Solving the Riddle
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE birth weight; confounding factors (epidemiology); infant mortality;
smoking
ID PERINATAL-MORTALITY; GESTATIONAL-AGE; INFANT; SMOKING; INCREASE
AB Small babies from a population with higher infant mortality often have better survival than small babies from a lower-risk population. This phenomenon can in principle be explained entirely by the presence of unmeasured confounding factors that increase mortality and decrease birth weight. Using a previously developed model for birth weight-specific mortality, the authors demonstrate specifically how strong unmeasured confounders can cause mortality curves stratified by known risk factors to intersect. In this model, the addition of a simple exposure (one that reduces birth weight and independently increases mortality) will produce the familiar reversal of risk among small babies. Furthermore, the model explicitly shows how the mix of high- and low-risk babies within a given stratum of birth weight produces lower mortality for high-risk babies at low birth weights. If unmeasured confounders are, in fact, responsible for the intersection of weight-specific mortality curves, then they must also (by virtue of being confounders) contribute to the strength of the observed gradient of mortality by birth weight. It follows that the true gradient of mortality with birth weight would be weaker than what is observed, if indeed there is any true gradient at all.
C1 [Basso, Olga] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
RP Basso, O (reprint author), Natl Inst Environm Hlth Sci, Epidemiol Branch, Mail Drop A3-05,POB 12233,111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM bassoo2@niehs.nih.gov
RI Basso, Olga/E-5384-2010;
OI Basso, Olga/0000-0001-9298-4921; Wilcox, Allen/0000-0002-3376-1311
FU Intramural NIH HHS [Z01 ES044003-30]; NIEHS NIH HHS [Z01 ES044003]
NR 21
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U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD APR 1
PY 2009
VL 169
IS 7
BP 787
EP 797
DI 10.1093/aje/kwp024
PG 11
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 421VX
UT WOS:000264387500001
PM 19240224
ER
PT J
AU Cameron, GN
Johnston, JJ
Randolph, JC
AF Cameron, Guy N.
Johnston, Jerry J.
Randolph, J. C.
TI Nutrient Encounter by a Generalist Herbivore in a Heterogeneous
Landscape
SO AMERICAN MIDLAND NATURALIST
LA English
DT Article
ID RATS SIGMODON-HISPIDUS; COTTON RATS; MOVEMENT PATTERNS; DIET
OPTIMIZATION; SELF-SELECTION; REPRODUCTION; RESOURCES; NUTRITION;
RESPONSES; BEHAVIOR
AB Most landscapes are heterogeneous in vegetation composition and thus, in the distribution of nutrients required by herbivores for growth and reproduction. Hispid cotton rats (Sigmodon hispdus) inhabit Texas coastal prairies which are characterized by habitat patches dominated by dicots, monocots or both [mixed) plant types. Hispid cotton rat's must obtain nutrients necessary for reproduction by ingesting both dicots and monocots, and reproductive females concentrate their activity in mixed patches. Mixed patches may be selected because they have high nutrient contents or because presence of both monocot and dicot food plants lowers cost of foraging movements. Because hispid cotton rats select a nutritionally complete diet and may detect protein by odor and taste cues, we hypothesized that nutrient concentrations may cue position of foraging paths. We used nutrient maps to measure amount of protein, P and Ca encountered during foraging from radiotracked individuals. We compared these values to those obtained from randomly generated foraging paths. Actual and random paths did not differ in amount of protein, P or Ca encountered. Differences in nutient accumulation between seasons were explained by seasonal differences in availability. We conclude that foraging paths do not respond to nutrient content of plants, but that reproductive females likely occupy mixed habitat patches because presence of both dicot and monocot food plants decreases time and energy spent foraging.
C1 [Cameron, Guy N.] Univ Cincinnati, Dept Biol Sci, Cincinnati, OH 45221 USA.
[Johnston, Jerry J.] US EPA, Washington, DC 20460 USA.
[Randolph, J. C.] Indiana Univ, Sch Publ & Environm Affairs, Bloomington, IN 47405 USA.
RP Cameron, GN (reprint author), Univ Cincinnati, Dept Biol Sci, Cincinnati, OH 45221 USA.
EM g.cameron@uc.edu
FU National Science Foundation [DEB 79-21766, DEB 7921496]; University of
Houston Coastal Center; GIS Laboratory, School of Public and
Environmental Affairs, Indiana University
FX We thank S. Spencer for collaborating in the field studies critical to
this research. This study was supported by National Science Foundation
grants DEB 79-21766 to JCR and DEB 7921496 to GNC, the University of
Houston Coastal Center and the GIS Laboratory, School of Public and
Environmental Affairs, Indiana University.
NR 35
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U1 0
U2 4
PU AMER MIDLAND NATURALIST
PI NOTRE DAME
PA UNIV NOTRE DAME, BOX 369, ROOM 295 GLSC, NOTRE DAME, IN 46556 USA
SN 0003-0031
J9 AM MIDL NAT
JI Am. Midl. Nat.
PD APR
PY 2009
VL 161
IS 2
BP 243
EP 250
DI 10.1674/0003-0031-161.2.243
PG 8
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 434GH
UT WOS:000265262700007
ER
PT J
AU Williams, MM
Yakrus, MA
Arduino, MJ
Cooksey, RC
Crane, CB
Banerjee, SN
Hilborn, ED
Donlan, RM
AF Williams, Margaret M.
Yakrus, Mitchell A.
Arduino, Matthew J.
Cooksey, Robert C.
Crane, Christina B.
Banerjee, Shailen N.
Hilborn, Elizabeth D.
Donlan, Rodney M.
TI Structural Analysis of Biofilm Formation by Rapidly and Slowly Growing
Nontuberculous Mycobacteria
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID WATER DISTRIBUTION-SYSTEMS; DRINKING-WATER; POTABLE WATER; SLIDING
MOTILITY; AIDS PATIENTS; AVIUM; ABSCESSUS; INFECTION; OUTBREAK;
SUSCEPTIBILITY
AB Mycobacterium avium complex (MAC) and rapidly growing mycobacteria (RGM) such as M. abscessus, M. mucogenicum, M. chelonae, and M. fortuitum, implicated in health care-associated infections, are often isolated from potable water supplies as part of the microbial flora. To understand factors that influence growth in their environmental source, clinical RGM and slowly growing MAC isolates were grown as biofilm in a laboratory batch system. High and low nutrient levels were compared, as well as stainless steel and polycarbonate surfaces. Biofilm growth was measured after 72 h of incubation by enumeration of bacteria from disrupted biofilms and by direct quantitative image analysis of biofilm microcolony structure. RGM biofilm development was influenced more by nutrient level than by substrate material, though both affected biofilm growth for most of the isolates tested. Microcolony structure revealed that RGM develop several different biofilm structures under high-nutrient growth conditions, including pillars of various shapes (M. abscessus and M. fortuitum) and extensive cording (M. abscessus and M. chelonae). Although it is a slowly growing species in the laboratory, a clinical isolate of M. avium developed more culturable biofilm in potable water in 72 h than any of the 10 RGM examined. This indicates that M. avium is better adapted for growth in potable water systems than in laboratory incubation conditions and suggests some advantage that MAC has over RGM in low-nutrient environments.
C1 [Williams, Margaret M.; Arduino, Matthew J.; Crane, Christina B.; Banerjee, Shailen N.; Donlan, Rodney M.] Ctr Dis Control & Prevent, Div Healthcare Qual Promot, Atlanta, GA 30333 USA.
[Yakrus, Mitchell A.; Cooksey, Robert C.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA 30333 USA.
[Hilborn, Elizabeth D.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC USA.
RP Williams, MM (reprint author), Ctr Dis Control & Prevent, Div Healthcare Qual Promot, 1600 Clifton Rd,MS-C16, Atlanta, GA 30333 USA.
EM MWilliams7@cdc.gov
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U2 17
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD APR 1
PY 2009
VL 75
IS 7
BP 2091
EP 2098
DI 10.1128/AEM.00166-09
PG 8
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 424EX
UT WOS:000264549400034
PM 19201956
ER
PT J
AU Karim, MR
Rhodes, ER
Brinkman, N
Wymer, L
Fout, GS
AF Karim, Mohammad R.
Rhodes, Eric R.
Brinkman, Nichole
Wymer, Larry
Fout, G. Shay
TI New Electropositive Filter for Concentrating Enteroviruses and
Noroviruses from Large Volumes of Water
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID ENTERIC VIRUS CONCENTRATION; REVERSE TRANSCRIPTION-PCR;
POLYMERASE-CHAIN-REACTION; ROUND STRUCTURED VIRUSES; TAP WATER;
DRINKING-WATER; POLIOVIRUS CONCENTRATION; MICROPOROUS FILTERS;
WASTE-WATER; GLASS WOOL
AB The U.S. Environmental Protection Agency's information collection rule requires the use of 1MDS electropositive filters for concentrating enteric viruses from water, but unfortunately, these filters are not cost-effective for routine viral monitoring. In this study, an inexpensive electropositive cartridge filter, the Nano-Ceram filter, was evaluated for its ability to concentrate enteroviruses and noroviruses from large volumes of water. Seeded viruses were concentrated using the adsorption-elution procedure. The mean percent retention of seeded polioviruses by NanoCeram filters was 84%. To optimize the elution procedure, six protocols, each comprising two successive elutions with various lengths of filter immersion, were evaluated. The highest virus recovery (77%) was obtained by immersing the filters in beef extract for 1 minute during the first elution and for 15 min during the second elution. The recovery efficiencies of poliovirus, coxsackievirus B5, and echovirus 7 from 100-liter samples of seeded tap water were 54%, 27%, and 32%, respectively. There was no significant difference in virus recovery from tap water with a pH range of 6 to 9.5 and a water flow rate range of 5.5 liters/min to 20 liters/min. Finally, poliovirus and Norwalk virus recoveries by NanoCeram filters were compared to those by 1MDS filters, using tap water and Ohio River water. Poliovirus and Norwalk virus recoveries by NanoCeram filters from tap and river water were similar to or higher than those by the 1MDS filters. These data suggest that NanoCeram filters can be used as an inexpensive alternative to 1MDS filters for routine viral monitoring of water.
C1 [Karim, Mohammad R.; Rhodes, Eric R.; Brinkman, Nichole; Fout, G. Shay] US EPA, Biohazard Assessment Res Branch, Cincinnati, OH 45268 USA.
[Karim, Mohammad R.; Rhodes, Eric R.; Brinkman, Nichole; Fout, G. Shay] US EPA, Immediate Off, Cincinnati, OH 45268 USA.
[Wymer, Larry] US EPA, Assessment Res Div, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Karim, MR (reprint author), US EPA, Biohazard Assessment Res Branch, 26 Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM Karim.Mohammad@epa.gov
FU Oak Ridge Institute for Science and Education; U.S. Environmental
Protection Agency; National Exposure Research Laboratory
FX This report has been subjected to the agency's peer and administrative
review and has been approved for publication. The mention of trade names
or commercial products in this report does not constitute endorsement or
recommendation for use.
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U1 2
U2 37
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD APR
PY 2009
VL 75
IS 8
BP 2393
EP 2399
DI 10.1128/AEM.00922-08
PG 7
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 429RC
UT WOS:000264936800018
PM 19218410
ER
PT J
AU Cripe, GM
Hemmer, BL
Goodman, LR
Vennari, JC
AF Cripe, G. M.
Hemmer, B. L.
Goodman, L. R.
Vennari, J. C.
TI Development of a Methodology for Successful Multigeneration Life-Cycle
Testing of the Estuarine Sheepshead Minnow, Cyprinodon variegatus
SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
ID TOXICITY; LACEPEDE; FISH
AB Evaluation of effects on fish reproduction and development during chemical exposures lasting for multiple generations is sometimes limited by variable reproductive responses and the time required for the exposure. Established testing methods and the short life cycle of the sheepshead minnow, Cyprinodon variegatus, make this species particularly suitable for use in identifying potential impacts of contaminants in estuarine and marine environments. This study describes the refinement of life-cycle exposure methods that increased the reliability of reproduction in sheepshead minnows and reduced the time to maturation for larvae and juvenile fishes. A test of three spawning chamber designs, three sex ratios, and two photoperiods identified conditions that reduced the coefficient of variation in egg production from > 100% to as little as 32%. The most reliable results were produced with groups of three female and two male fishes (all of similar size) when they were placed in a rectangular chamber and acclimated for 12 days. A test water temperature of 26.5 +/- A 2A degrees C and a 14L:10D photoperiod resulted in fish producing a mean of 74 embryos per female per day, with a coefficient of variation of 31.8%. Egg fertility exceeded 90%, with a hatch rate of 95% for normal embryos (a parts per thousand yen80% yolk) and a hatch rate of a parts per thousand currency sign45% for embryos containing a parts per thousand currency sign77% yolk. The length of time to grow larvae to spawning adult fish was reduced to similar to 60 days posthatch by feeding them flake food twice daily to satiation for 15 min, and it was observed that size (a parts per thousand yen2.7 cm standard length) was critical for spawning readiness. Adult fish were prepared for the spawning assessment by adding frozen brine shrimp to their diet. Results of these experiments provide methods that are of particular interest in assessment of endocrine-disrupting chemicals that are known to affect reproduction.
C1 [Cripe, G. M.; Hemmer, B. L.; Goodman, L. R.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
[Vennari, J. C.] Senior Serv Amer Inc, Gulf Breeze, FL 32561 USA.
RP Cripe, GM (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM cripe.geraldine@epa.gov
NR 26
TC 7
Z9 7
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-4341
J9 ARCH ENVIRON CON TOX
JI Arch. Environ. Contam. Toxicol.
PD APR
PY 2009
VL 56
IS 3
BP 500
EP 508
DI 10.1007/s00244-008-9204-8
PG 9
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 422XS
UT WOS:000264461600015
PM 18704253
ER
PT J
AU Lund, AK
Lucero, J
Lucas, S
Madden, MC
McDonald, JD
Seagrave, JC
Knuckles, TL
Campen, MJ
AF Lund, Amie K.
Lucero, JoAnn
Lucas, Selita
Madden, Michael C.
McDonald, Jacob D.
Seagrave, Jean-Clare
Knuckles, Travis L.
Campen, Matthew J.
TI Vehicular Emissions Induce Vascular MMP-9 Expression and Activity
Associated With Endothelin-1-Mediated Pathways
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE atherosclerosis; endothelin-1; matrix metalloproteinase; reactive oxygen
species; air pollution
ID PARTICULATE AIR-POLLUTION; MATRIX METALLOPROTEINASES;
SUPEROXIDE-PRODUCTION; MYOCARDIAL-INFARCTION; HUMAN ATHEROSCLEROSIS;
NAD(P)H OXIDASE; HEART-DISEASE; TERM EXPOSURE;
MATRIX-METALLOPROTEINASE-9; EXHAUST
AB Objective-Mechanisms of air pollution-induced exacerbation of cardiovascular disease are currently unknown, thus we examined the roles of vascular endothelin-1 (ET-1) and reactive oxygen species (ROS) in regulating mediators of vascular remodeling, namely matrix metalloproteinases (MMPs), after exposure to vehicle engine emissions.
Methods and Results-ApoE(-/-) mice were exposed by inhalation to filtered air or gasoline engine exhaust (GEE, 1: 12 dilution) 6 hours per day for 1 or 7 days. Concurrently, mice were treated with either ET(A) receptor antagonist BQ-123 (100 ng/kg/d) via osmotic minipumps, Tempol (approximate to 41 mg/kg/d, orally), or vehicle. GEE-exposure increased vascular MMP-2 and -9, endothelin-1 (ET-1), tissue inhibitor of metalloproteinases (TIMP)-2 mRNA and ROS levels. Aortic MMP protein and plasma MMP-9 were similarly upregulated. GEE-mediated increases in vascular ROS were attenuated by Tempol-treatment, as were MMP-2 and TIMP-2; whereas BQ-123 ameliorated GEE-induced vascular expression of MMP-9, MMP-2, ROS, and ET-1. In a parallel study, diesel exhaust exposure in volunteer human subjects induced significant increases in plasma ET-1 and MMP-9 expression and activity.
Conclusions-These findings demonstrate that acute exposure to vehicular source air pollutants results in upregulation of circulating and vascular factors associated with progression of atherosclerosis, mediated in part through activation of ET-1-ET(A) receptor pathways. (Arterioscler Thromb Vasc Biol. 2009; 29: 511-517.)
C1 [Lund, Amie K.; Lucero, JoAnn; Lucas, Selita; McDonald, Jacob D.; Seagrave, Jean-Clare; Knuckles, Travis L.; Campen, Matthew J.] Lovelace Resp Res Inst, Dept Toxicol, Albuquerque, NM 87108 USA.
[Madden, Michael C.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Chapel Hill, NC USA.
RP Campen, MJ (reprint author), Lovelace Resp Res Inst, Dept Toxicol, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108 USA.
EM mcampen@lrri.org
FU National Environmental Respiratory Center; United States Environmental
Protection Agency (EPA) Star Award [R830839-010]; National Institute of
Environmental Health Sciences (NIEHS) [F32ES015404, ES014639]
FX This project was supported by the National Environmental Respiratory
Center, a United States Environmental Protection Agency (EPA) Star Award
(R830839-010), and Grants F32ES015404 and ES014639 from the National
Institute of Environmental Health Sciences (NIEHS). The content is
solely the responsibility of the authors and does not necessarily
represent the official views of the NIEHS, the NIH, or the EPA.
NR 34
TC 69
Z9 73
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1079-5642
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD APR
PY 2009
VL 29
IS 4
BP 511
EP U161
DI 10.1161/ATVBAHA.108.176107
PG 29
WC Hematology; Peripheral Vascular Disease
SC Hematology; Cardiovascular System & Cardiology
GA 421EQ
UT WOS:000264342600016
PM 19150882
ER
PT J
AU Brook, JR
Demerjian, KL
Hidy, G
Molina, LT
Pennell, WI
Scheffe, R
AF Brook, Jeffrey R.
Demerjian, Kenneth L.
Hidy, George
Molina, Luisa T.
Pennell, William I.
Scheffe, Richard
TI New Directions: Results-oriented multi-pollutant air quality management
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Editorial Material
C1 [Brook, Jeffrey R.] Environm Canada, Atmospher Sci & Technol Directorate, Air Qual Res Div, Toronto, ON M3H 5T4, Canada.
[Demerjian, Kenneth L.] SUNY Albany, Atmospher Sci Res Ctr, Albany, NY 12203 USA.
[Demerjian, Kenneth L.] SUNY Albany, Dept Earth & Atmospher Sci, Albany, NY 12203 USA.
[Hidy, George] Envair Aerochem, Placitas, NM 87043 USA.
[Molina, Luisa T.] MIT, La Jolla, CA 92037 USA.
[Molina, Luisa T.] Molina Ctr Energy & Environm, La Jolla, CA 92037 USA.
[Pennell, William I.] Columbia Res & Educ Associates, Columbia, WA 99301 USA.
[Scheffe, Richard] US EPA, Durham, NC 27711 USA.
RP Brook, JR (reprint author), Environm Canada, Atmospher Sci & Technol Directorate, Air Qual Res Div, 4905 Dufferin St, Toronto, ON M3H 5T4, Canada.
EM jeff.brook@ec.gc.ca; kld@asrc.cestm.albany.edu; dhidy113@comcast.net;
ltmolina@mit.edu; bill@craea.com; scheffe.rich@epamail.epa.gov
NR 3
TC 4
Z9 4
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD APR
PY 2009
VL 43
IS 12
BP 2091
EP 2093
DI 10.1016/j.atmosenv.2008.12.041
PG 3
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 430PB
UT WOS:000264999900019
ER
PT J
AU Rowsey, PJ
Metzger, BL
Carlson, J
Gordon, CJ
AF Rowsey, Pamela Johnson
Metzger, Bonnie L.
Carlson, John
Gordon, Christopher J.
TI Long-Term Exercise Training Selectively Alters Serum Cytokines Involved
in Fever
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE cytokines; exercise; fever
ID IN-CORE TEMPERATURE; ELEVATION; RESPONSES; MICE; LIPOPOLYSACCHARIDE;
RAT; LPS
AB Long-term exercise training selectively alters serum cytokines involved in fever. Chronic exercise training has a number of effects on the immune system that may mimic the physiological response to fever. Female rats that voluntarily exercise on running wheels develop an elevated daytime core temperature after several weeks of training. It remains to be seen whether the elevation in daytime temperature involves inflammatory patterns characteristic of an infectious fever. We assessed whether chronic exercise training in the rat would alter levels of cytokines involved in fever. Female Sprague Dawley rats at 4 5 days of age weighing 90-110 g were divided into two groups (exercise and sedentary) and housed at an ambient temperature of 22 degrees C. Interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-alpha), iron, and zinc levels were analyzed. Rats underwent 8 weeks of exercise on running wheels. Exercise led to altered levels of some key cytokines that are involved in fever. Exercise animals had significantly higher IL-1 beta levels and lower IL-10 levels compared to sedentary animals. Although IL-6 levels were slightly lower in the exercise animals, these levels were not significantly affected by training. TNF-alpha activity was similar in the two groups. Training also led to a slight increase in serum zinc and decrease in serum unsaturated iron binding capacity (UIBC). The data suggest that chronic exercise training evokes immune responses that mimic some, but not all, aspects of fever. This may explain why exercise leads to elevated daytime core temperature.
C1 [Rowsey, Pamela Johnson; Carlson, John] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA.
[Gordon, Christopher J.] US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA.
RP Rowsey, PJ (reprint author), Univ N Carolina, Sch Nursing, CB 7460 Carrington Hall, Chapel Hill, NC 27599 USA.
EM pjrowsey@unc.edu
FU National Institute of Nursing Research [5-RO1-NR04920-01-03]; National
Health and Environmental Effects Research Laboratory; U.S. Environmental
Protection Agency
FX This project was supported by an RO1 grant from the National Institute
of Nursing Research, grant number 5-RO1-NR04920-01-03. This paper has
been reviewed by the National Health and Environmental Effects Research
Laboratory, U.S. Environmental Protection Agency, and approved for
publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 26
TC 12
Z9 12
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD APR
PY 2009
VL 10
IS 4
BP 374
EP 380
DI 10.1177/1099800408329409
PG 7
WC Nursing
SC Nursing
GA 427QI
UT WOS:000264793400008
PM 19190031
ER
PT J
AU Hosni, AA
Shane, WT
Szabo, JG
Bishop, PL
AF Hosni, Ahmed A.
Shane, William T.
Szabo, Jeffery G.
Bishop, Paul L.
TI The disinfection efficacy of chlorine and chlorine dioxide as
disinfectants of Bacillus globigii, a surrogate for Bacillus anthracis,
in water networks: A comparative study
SO CANADIAN JOURNAL OF CIVIL ENGINEERING
LA English
DT Article
DE disinfection kinetics; disinfection efficacy; chlorine; chlorine
dioxide; Bacillus globigii
ID CRYPTOSPORIDIUM-PARVUM OOCYSTS; INACTIVATION; BIOFILMS; PENETRATION;
SPORES; DIFFUSION; SUBTILIS; OZONE; MODEL
AB Intentional contamination of drinking water with anthrax spores is a concern to water utilities. The spores may become embedded in the distribution pipe corrosion and biofilm, where they will be protected from residual disinfectants. This paper compares the disinfection effectiveness of chlorine and chlorine dioxide on Bacillus globigii, a surrogate for B. anthracis. Batch experiments were performed using both disinfectants. Data was analyzed using the delayed Chick-Watson model to determine the corresponding CT(lag) (CT = concentration x time) values and Watson plots, which indicate the dominant factors affecting disinfection kinetics. Chlorine dioxide had CTlag values almost one tenth of those observed for chlorine. However, Watson plots showed that exposure time and disinfectant concentrations have equal weights on the inactivation rate of both disinfectants.
C1 [Hosni, Ahmed A.; Shane, William T.; Bishop, Paul L.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
[Szabo, Jeffery G.] US EPA, Natl Homeland Secur Res Ctr, Water Infrastructure Protect Div, Cincinnati, OH 45268 USA.
RP Bishop, PL (reprint author), Univ Cincinnati, Dept Civil & Environm Engn, 765 Baldwin Hall, Cincinnati, OH 45221 USA.
EM paul.bishop@uc.edu
FU United States Environmental Protection Agency; Office of Research and
Development [EP-C05-056]
FX The United States Environmental Protection Agency through its Office of
Research and Development funded and managed the research described here
under contract EP-C05-056. It has been subjected to Agency's
administrative review and approved for publication. Mention of trade
names or commercial products does not constitute endorsement or
recommendation for use.
NR 20
TC 8
Z9 8
U1 2
U2 12
PU NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS
PI OTTAWA
PA BUILDING M 55, OTTAWA, ON K1A 0R6, CANADA
SN 0315-1468
J9 CAN J CIVIL ENG
JI Can. J. Civ. Eng.
PD APR
PY 2009
VL 36
IS 4
BP 732
EP 737
DI 10.1139/L09-001
PG 6
WC Engineering, Civil
SC Engineering
GA 439CP
UT WOS:000265605500021
ER
PT J
AU Liu, SL
Li, YH
Shi, GY
Tang, SH
Jiang, SJ
Huang, CW
Liu, PY
Hong, JS
Wu, HL
AF Liu, Shu-Lin
Li, Yi-Heng
Shi, Guey-Yueh
Tang, Sei-Hui
Jiang, Shinn-Jong
Huang, Chia-Wei
Liu, Ping-Yen
Hong, Jau-Shyong
Wu, Hua-Lin
TI Dextromethorphan reduces oxidative stress and inhibits atherosclerosis
and neointima formation in mice
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE Atherosclerosis; Macrophages; Anti-oxidants
ID SUPEROXIDE ANION PRODUCTION; NADPH OXIDASE; DOPAMINERGIC-NEURONS;
ACTIVATION; EXPRESSION; NEUTROPHILS; P47PHOX; DISEASE; INJURY; ARTERY
AB Macrophage-related oxidative stress plays an important role in the inflammatory process in atherosclerosis. Recently, dextromethorphan (DXM), a common cough-suppressing ingredient with a high safety profile, was found to inhibit the activation of microglia, the resident macrophage in the nervous system. We investigated whether DXM could reduce macrophage production of cytokines and superoxide and the resultant influence on atherosclerosis formation in mice.
We used in vitro and in vivo studies to evaluate the DXM inhibitory effect on oxidative stress. Dextromethorphan pretreatment significantly suppressed the production of tumour necrosis factor-alpha, monocyte chemoattractant protein-1, interleukin-6, interleukin-10, and superoxide in macrophage cell culture after stimulation. Indeed, DXM reduced macrophage nicotinamide adenine dinucleotide phosphate oxidase activity by decreasing membrane translocation of p47(phox) and p67(phox) through the inhibition of protein kinase C and extracellular signal-regulated kinase activation. The anti-atherosclerosis effect of DXM was tested using two animal models, apolipoprotein E (apoE)-deficient mice and a mouse carotid ligation model. Dextromethorphan treatment (10-40 mg/kg/day) for 10 weeks in apoE-deficient mice significantly reduced superoxide production in their polymorphonuclear leukocytes and aortas. It significantly decreased the severity of aortic atherosclerosis in the apoE-deficient mice and decreased carotid neointima formation after ligation in C57BL/6 mice.
Our data show that DXM, with its novel effect in reducing oxidative stress, significantly reduces atherosclerosis and neointima formation in mice.
C1 [Liu, Shu-Lin; Shi, Guey-Yueh; Tang, Sei-Hui; Jiang, Shinn-Jong; Huang, Chia-Wei; Wu, Hua-Lin] Natl Cheng Kung Univ, Coll Med, Dept Biochem & Mol Biol, Tainan 701, Taiwan.
[Li, Yi-Heng; Liu, Ping-Yen] Natl Cheng Kung Univ, Coll Med, Dept Internal Med, Tainan 701, Taiwan.
[Li, Yi-Heng; Shi, Guey-Yueh; Tang, Sei-Hui; Jiang, Shinn-Jong; Liu, Ping-Yen; Wu, Hua-Lin] Natl Cheng Kung Univ, Cardiovasc Res Ctr, Tainan 701, Taiwan.
[Hong, Jau-Shyong] Natl Inst Environm Hlth Sci, Neuropharmacol Sect, Lab Pharmacol & Chem, Res Triangle Pk, NC USA.
RP Shi, GY (reprint author), Natl Cheng Kung Univ, Coll Med, Dept Biochem & Mol Biol, Tainan 701, Taiwan.
EM gyshi@mail.ncku.edu.tw; halnwu@mail.ncku.edu.tw
FU National Science Council, Taipei, Taiwan, Republic of China [NSC
95-2752-B-006-003-PAE, NSC95-2752-B-006-004-PAE, NSC
95-2752-B-006-005-PAE]
FX This work was supported by the National Science Council, Taipei, Taiwan,
Republic of China ( Grants NSC 95-2752-B-006-003-PAE,
NSC95-2752-B-006-004-PAE, and NSC 95-2752-B-006-005-PAE).
NR 25
TC 20
Z9 21
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD APR 1
PY 2009
VL 82
IS 1
BP 161
EP 169
DI 10.1093/cvr/cvp043
PG 9
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA 418ZV
UT WOS:000264189800021
PM 19189960
ER
PT J
AU Zhao, BZ
He, YY
Chignell, CF
Yin, JJ
Andley, U
Roberts, JE
AF Zhao, Baozhong
He, Yu-Ying
Chignell, Colin F.
Yin, Jun-Jie
Andley, Usha
Roberts, Joan E.
TI Difference in Phototoxicity of Cyclodextrin Complexed Fullerene
[(gamma-CyD)(2)/C-60] and Its Aggregated Derivatives toward Human Lens
Epithelial Cells
SO CHEMICAL RESEARCH IN TOXICOLOGY
LA English
DT Article
ID WATER-SOLUBLE FULLERENES; SINGLET OXYGEN; PROTEIN PEROXIDES; STATE
PROPERTIES; PLASMA-MEMBRANE; UV-RADIATION; MALONIC-ACID; C-60;
CYTOTOXICITY; LIGHT
AB The water-soluble fullerene derivative gamma-cyclodextrin bicapped C-60 [(gamma-CyD)(2)/C-60, CDF0] has several clinical applications, including use as a drug carrier to bypass the blood ocular barriers or a photosensitizer to treat tumors in photodynamic therapy. We have assessed the potential ocular toxicity of (gamma-CyD)(2)/C-60 and its aggregated derivatives induced by UVA and visible light in vitro in human lens epithelial cells (HLE B-3). Cell viability using the MTS assay demonstrated that 2 mu M (gamma-CyD)(2)/C-60 was highly phototoxic to HLE B-3 cells with UVA irradiation, while no effect was observed in the presence of visible light or when maintained in the dark. In contrast, the aggregated derivative (CDF150) showed neither cytotoxicity nor any phototoxic effect even at 30 mu M with either UVA or visible light irradiation. In lens cells treated with (gamma-CyD)(2)/C-60, phototoxicity was manifested as apoptosis. Singlet oxygen production measurement using the EPR/TEMP trapping technique determined that (gamma-CyD)(2)/C60 (CDF0) efficiently produced singlet oxygen. The rate of singlet oxygen production decreased with increased aggregation, with no production by the fully aggregated sample formed after 150 min of heating (CDF150). UVA irradiation of HLE B-3 in the presence of (gamma-CyD)(2)/C-60 resulted in a significant rise in intracellular protein-derived peroxides. The singlet oxygen quenchers sodium azide and histidine each significantly protected lens cells against (gamma-CyD)(2)/C-60 photodamage, but lutein and Trolox (vitamin E) did not. Clearly, singlet oxygen is an important intermediate in the phototoxicity of monomeric (gamma-CyD)(2)/fullerene. Our results also demonstrate that UVA-blocking sunglasses can limit the ocular phototoxicity of this nanomaterial, while nontoxic endogenous antioxidants like lutein or Trolox cannot provide adequate protection.
C1 [Roberts, Joan E.] Fordham Univ, Dept Nat Sci, New York, NY 10023 USA.
[Yin, Jun-Jie] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA.
[Andley, Usha] Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA.
[Zhao, Baozhong; He, Yu-Ying; Chignell, Colin F.] Natl Inst Environm Hlth Sci, Pharmacol Lab, Res Triangle Pk, NC 27709 USA.
RP Roberts, JE (reprint author), Fordham Univ, Dept Nat Sci, 113 W 60th St, New York, NY 10023 USA.
EM jroberts@fordham.edu
RI Zhao, Baozhong/B-5865-2011; Yin, Jun Jie /E-5619-2014
FU NIH; National Institute of Environmental Health Sciences
FX This paper is dedicated to the memory of Dr. Colin F. Chignell. This
research was supported by the Intramural Research Program of the NIH,
National Institute of Environmental Health Sciences. We thank Dr. Ann
Motten, NIEHS, for help in preparation of this manuscript and Dr. Carl
Bortner and Maria Sifre for their assistance with flow cytometry
measurements. This manuscript has been reviewed by the National
Institutes of Environmental Health Sciences and approved for
publication.
NR 54
TC 38
Z9 41
U1 3
U2 26
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0893-228X
J9 CHEM RES TOXICOL
JI Chem. Res. Toxicol.
PD APR
PY 2009
VL 22
IS 4
BP 660
EP 667
DI 10.1021/tx800478u
PG 8
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
SC Pharmacology & Pharmacy; Chemistry; Toxicology
GA 436KF
UT WOS:000265412300009
PM 19281132
ER
PT J
AU Nadagouda, MN
Schock, M
Metz, DH
DeSantis, MK
Lytle, D
Welch, M
AF Nadagouda, Mallikarjuna N.
Schock, Michael
Metz, Deborah H.
DeSantis, Michael K.
Lytle, Darren
Welch, Meghan
TI Effect of Phosphate Inhibitors on the Formation of Lead
Phosphate/Carbonate Nanorods, Microrods, and Dendritic Structures
SO CRYSTAL GROWTH & DESIGN
LA English
DT Article
ID SEMICONDUCTOR NANOWIRES; NANOTUBES; GROWTH; CARBON
AB There are several factors which influence the corrosion rate of lead, which in turn morphs into different crystal shapes and sizes. Some of the important factors are alkalinity, pH, calcium, orthophosphate, and silica. Low to moderate alkalinity decreases corrosion rates, while higher alkalinities have a tendency to increase the corrosion rates of lead. This work describes the effect of orthophosphate inhibitor and pH on the formation of different structures of lead phosphate/carbonate nanorods, nanobelts, microrods, and dendritic structures. The experiments were carried out at different pHs both with and without orthophosphate inhibitor under laboratory conditions, which were intended to represent actual drinking water distribution system (DWDS) conditions. The surface morphology and crystal structure of the different crystals were obtained using scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDS), transmission electron microscopy (TEM), and selected area diffraction pattern (SAED). The phase identification was done using powder X-ray diffraction (PXRD). With the increase in pH from 6.5 to 8.5, the formation of uniform thickness coating of phosphate containing minerals was observed, which was in contrast to the different crystal growth under low pH conditions. The XRD patterns indicate that the surface solids contain a mixture of many phases.
C1 [Nadagouda, Mallikarjuna N.; DeSantis, Michael K.; Welch, Meghan] Pegasus Tech Serv, Cincinnati, OH 45219 USA.
[Schock, Michael; Lytle, Darren] US EPA, Div Drinking Water Res, Risk Reduct Engn Lab, Cincinnati, OH 45268 USA.
[Metz, Deborah H.] Greater Cincinnati Water Works, Cincinnati, OH 45232 USA.
RP Nadagouda, MN (reprint author), Pegasus Tech Serv, 46 E Hollister St, Cincinnati, OH 45219 USA.
EM nadagouda.mallikarjuna@epa.gov; schock.michael@epa.gov
FU The U.S. Environmental Protection Agency, through its Office of Research
and Development
FX M.N.N. is thankful to Cristina Bennet-Stamper for the microscopic
facility and to Dr. Thomas Speth for the encouragement. The U.S.
Environmental Protection Agency, through its Office of Research and
Development, funded and managed, or partially funded and collaborated
in, the research described herein. It has been subjected to the Agency's
peer and administrative review and has been approved for external
publication. Any opinions expressed are those of the author(s) and do
not necessarily reflect the views of the Agency, and therefore, no
official endorsement should be inferred. Any mention of trade names or
commercial products does not constitute endorsement or recommendation
for use.
NR 22
TC 9
Z9 9
U1 0
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1528-7483
J9 CRYST GROWTH DES
JI Cryst. Growth Des.
PD APR
PY 2009
VL 9
IS 4
BP 1798
EP 1805
DI 10.1021/cg8009699
PG 8
WC Chemistry, Multidisciplinary; Crystallography; Materials Science,
Multidisciplinary
SC Chemistry; Crystallography; Materials Science
GA 427SA
UT WOS:000264798200030
ER
PT J
AU Etterson, MA
Bennett, RS
Kershner, EL
Walk, JW
AF Etterson, Matthew A.
Bennett, Richard S.
Kershner, Eric L.
Walk, Jeffery W.
TI Markov chain estimation of avian seasonal fecundity
SO ECOLOGICAL APPLICATIONS
LA English
DT Article
DE avian seasonal fecundity; Dickcissel; Eastern Meadowlark; Markov chain;
multiple-brooded birds; nest success; Spiza americana; Sturnella magna
ID NEST SUCCESS; REPRODUCTIVE SYNCHRONY; BREEDING PRODUCTIVITY;
POPULATION-DYNAMICS; CARDUELINE FINCH; SONGBIRDS; MODELS; BIRDS;
COMPONENTS; PARASITISM
AB Avian seasonal fecundity is of interest from evolutionary, ecological, and conservation perspectives. However, direct estimation of seasonal fecundity is difficult, especially with multi-brooded birds, and models representing the renesting and quitting processes are usually required. To explore the consequences of modeling decisions on inference about avian seasonal fecundity, we generalize previous Markov chain (MC) models of avian nest success to formulate two different MC models of avian seasonal fecundity that represent two different ways to model renesting decisions and breeding cessation. We parameterize both Markov chains (regular and absorbing) for two species (Eastern Meadowlark, Sturnella magna, and Dickcissel, Spiza americana) and compare the results using mean-square error of the estimated number of successful broods per breeding female. We also provide formulae for estimating the expected variation in female breeding success. The absorbing MC performed better for both species, although the regular MC performed almost as well when the duration of the breeding season was estimated by taking the 95th percentile of a negative binomial distribution fit to the observed durations among all females. In their simplest form the models contain very few parameters (four or five) and should also prove useful as a foundation for more complex models of avian seasonal fecundity and demography.
C1 [Etterson, Matthew A.; Bennett, Richard S.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Duluth, MN 55804 USA.
[Kershner, Eric L.] US Marine Corps Base Camp Pendleton, Environm Secur Wildlife Management Branch, Camp Pendleton, CA 92055 USA.
[Walk, Jeffery W.] Nature Conservancy, Peoria, IL 61602 USA.
RP Etterson, MA (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM etterson.matthew@epa.gov
FU U.S. Environmental Protection Agency
FX J. Grzybowski provided valuable comments on an earlier version of this
manuscript. The information in this document has been funded in part by
the U.S. Environmental Protection Agency. It has been subjected to
review by the National Health and Environmental Effects Research
Laboratory and approved for publication. Approval does not signify that
the contents reflect the views of the Agency, nor does mention of trade
names or commercial products constitute endorsement or recommendation
for use.
NR 45
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U1 0
U2 9
PU ECOLOGICAL SOC AMER
PI WASHINGTON
PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA
SN 1051-0761
J9 ECOL APPL
JI Ecol. Appl.
PD APR
PY 2009
VL 19
IS 3
BP 622
EP 630
DI 10.1890/08-0499.1
PG 9
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 420SM
UT WOS:000264309500012
PM 19425426
ER
PT J
AU Campbell, DE
Lu, HF
Knox, GA
Odum, HT
AF Campbell, Daniel E.
Lu, Hong-Fang
Knox, George A.
Odum, Howard T.
TI Maximizing empower on a human-dominated planet: The role of exotic
Spartina
SO ECOLOGICAL ENGINEERING
LA English
DT Review
DE Exotic Spartina; Emergy analysis; Energy Systems Theory; Maximum
empower; Human-dominated planet; Salt marshes
ID ENGLAND SALT-MARSH; WILLAPA BAY; PACIFIC-NORTHWEST;
PHRAGMITES-AUSTRALIS; SMOOTH CORDGRASS; SEDIMENT ACCUMULATION; EMERGY
EVALUATION; WASHINGTON-STATE; ACCRETION RATES; TIDAL MARSHES
AB The emergy signature of the earth has changed dramatically over the past 250 years as a result of the development of technologies to use fossil fuels for human purposes. This change has resulted in the self-organization of modern industrial societies and their concomitant processes now dominate the earth. One such process is the transport of species from specific regions of the Earth, to which they were formerly confined, and their introduction to new territories. In this paper, we examine the role of exotic Spartina sp. in promoting the self-organization of coastal ecosystems for maximum empower on three coasts, Marlborough Sounds, NZ, Willapa Bay, WA, USA and Jiangsu Province, PRC. We found evidence to support the hypothesis that Spartina marsh maximizes empower through the building of new land in coastal environments that are dominated by an excess of sediment. Where excess sediments are present as a consequence of past geologic processes, and where a low marsh plant was absent, Spartina has been seen as an interloper to be destroyed. There is some evidence that given sufficient time, exotic Spartina marshes may increase productivity and diversity in these coastal systems, as well as those that are actively prograding. (C) 2008 Elsevier B.V All rights reserved
C1 [Lu, Hong-Fang] Chinese Acad Sci, S China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China.
[Campbell, Daniel E.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI USA.
[Knox, George A.] Univ Canterbury, Christchurch 1, New Zealand.
[Odum, Howard T.] Univ Florida, Gainesville, FL USA.
RP Lu, HF (reprint author), Chinese Acad Sci, S China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China.
EM luhf@scbg.ac.cn
FU National Science Foundation of China [30600072]; Director's Award of the
Chinese Academy of Sciences; Atlantic Ecology Division, NHEERL, ORD
[AED-08-049]
FX Work on the S. anglica marsh in New Zealand was carried out with the
assistance of Andrew Baxter, Elisabeth Odum, Phillip Reed, Kathleen
Trimmer, Hudson Dean and Roger Waite. Field observations at Willapa Bay
were carried out with David Specht of the Newport Oregon Laboratory,
Western Ecology Division, National Health and Environmental Effects
Research Laboratory (NHEERL), Office of Research and Development (ORD).
Our work on the Yancheng Biosphere Reserve was aided by Chen Jie, Qin
Pei, Ren Hai and Zhang Xue-Qin. We thank Glen Thursby, Cathleen Wigand
and Henry Walker for helpful internal reviews of the manuscript and
Chung-Hsin Juan and C.A. Simenstad for helpful external reviews. The
opinions expressed in this paper are the authors' and do not reflect the
official opinions and policies of the USEPA. This paper is partly
supported by Projects of the National Science Foundation of China
(30600072) and the Director's Award of the Chinese Academy of Sciences,
and it is also contribution number AED-08-049 of the Atlantic Ecology
Division, NHEERL, ORD.
NR 146
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U1 1
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-8574
J9 ECOL ENG
JI Ecol. Eng.
PD APR
PY 2009
VL 35
IS 4
BP 463
EP 486
DI 10.1016/j.ecoleng.2008.07.022
PG 24
WC Ecology; Engineering, Environmental; Environmental Sciences
SC Environmental Sciences & Ecology; Engineering
GA 446RK
UT WOS:000266138600005
ER
PT J
AU Liu, LL
King, JS
Giardina, CP
Booker, FL
AF Liu, Lingli
King, John S.
Giardina, Christian P.
Booker, Fitzgerald L.
TI The Influence of Chemistry, Production and Community Composition on Leaf
Litter Decomposition Under Elevated Atmospheric CO2 and Tropospheric O-3
in a Northern Hardwood Ecosystem
SO ECOSYSTEMS
LA English
DT Article
DE condensed tannins; FACE; global change; lignin; litter productivity;
mean residence time; plant community composition; soluble phenolics;
soil carbon storage
ID SOIL MICROBIAL COMMUNITY; PAPER BIRCH COMMUNITIES; CARBON-DIOXIDE;
TREMBLING ASPEN; AND/OR O-3; NITROGEN DEPOSITION; YOUNG STANDS; OZONE;
FOREST; PINE
AB We examined the effects of elevated CO2 and O-3 and their interaction on leaf litter chemistry and decomposition in pure stands of aspen (Populus tremuloides) and mixed stands of birch (Betula papyrifera) and aspen at the Aspen Free Air CO2 Enrichment (FACE) experiment. A 935-day in situ incubation study was performed using litterbags filled with naturally senesced leaf litter. We found that elevated CO2 had no overall effects on litter decomposition rates, whereas elevated O-3 reduced litter mass loss (-13%) in the first year. The effect of O-3 on mass loss disappeared in the second year. For aspen litter but not mixed birch-aspen litter, decomposition rates were negatively correlated with initial concentrations of condensed tannins and phenolics. Most soluble components (94% of soluble sugars, 99% of condensed tannins, and 91% of soluble phenolics) and any treatment effects on their initial concentrations disappeared rapidly. However, the mean residence time (MRT) of birch-aspen litter (3.1 years) was significantly lower than that of aspen litter (4.8 years). Further, because of variation in total litterfall, total litter mass, C, lignin and N remaining in the ecosystem was highest under elevated CO2 and lowest under elevated O-3 during the incubation period. Our results indicate that elevated CO2 and O-3 can alter short-term litter decomposition dynamics, but longer-term effects will depend more on indirect effects mediated through changes in forest community composition. Treatment effects on soluble components are likely to influence cyclical microbial processes and carbon pulses in the ecosystem only when coupled with increased (CO2) or decreased (O-3) litter inputs.
C1 [Liu, Lingli; King, John S.] N Carolina State Univ, Dept Forestry & Environm Resources, Raleigh, NC 27965 USA.
[Giardina, Christian P.] USDA, Forest Serv, Inst Pacific Isl Forestry, PSW Res Stn, Hilo, HI 96720 USA.
[Booker, Fitzgerald L.] USDA, Agr Res Serv, Plant Sci Res Unit, Raleigh, NC 27607 USA.
[Liu, Lingli] US EPA, Environm Media Assessment Grp, Natl Ctr Environ Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Liu, LL (reprint author), N Carolina State Univ, Dept Forestry & Environm Resources, Campus Box 8002, Raleigh, NC 27965 USA.
EM lingliliu@hotmail.com
RI Liu, Lingli/A-7771-2008; Giardina, Christian/C-3120-2011
OI Liu, Lingli/0000-0002-5696-3151; Giardina, Christian/0000-0002-3431-5073
FU Office of Science (BER), U.S. Department of Energy [DE-FG02-95ER62125,
DE-AC02-98CH10886]; U.S. Forest Service Northern Global Change Program
and Northern Research Station; Michigan Technological University;
Natural Resources Canada-Canadian Forest Service; USDA NRI Competitive
Grants Program [2001-35107-11262, 2004-35102-16723]
FX Aspen FACE is principally supported by the Office of Science (BER), U.S.
Department of Energy, Grant No. DE-FG02-95ER62125 to Michigan
Technological University, and Contract No. DE-AC02-98CH10886 to
Brookhaven National Laboratory, the U.S. Forest Service Northern Global
Change Program and Northern Research Station, Michigan Technological
University, and Natural Resources Canada-Canadian Forest Service.
Additional support provided by USDA NRI Competitive Grants Program Nos.
2001-35107-11262 and 2004-35102-16723, USDA Forest Service the Northern
Institute of Applied Carbon Science and the Pacific Southwest Research
Station, the Graduate School of North Carolina State University, the
Research Participation Program at the National Center for Environmental
Assessment, U.S. Environmental Protection Agency administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and EPA.
NR 53
TC 19
Z9 19
U1 3
U2 57
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1432-9840
EI 1435-0629
J9 ECOSYSTEMS
JI Ecosystems
PD APR
PY 2009
VL 12
IS 3
BP 401
EP 416
DI 10.1007/s10021-009-9231-y
PG 16
WC Ecology
SC Environmental Sciences & Ecology
GA 424EC
UT WOS:000264547300005
ER
PT J
AU Granek, EF
Compton, JE
Phillips, DL
AF Granek, Elise F.
Compton, Jana E.
Phillips, Donald L.
TI Mangrove-Exported Nutrient Incorporation by Sessile Coral Reef
Invertebrates
SO ECOSYSTEMS
LA English
DT Article
DE bivalve; coral; macroalgae; mangrove forest; nutrient exchange;
phytoplankton; seagrass; sponge; stable isotope
ID STABLE-ISOTOPE; ORGANIC-MATTER; CONTINENTAL MARGINS; RELATIVE
IMPORTANCE; PENAEID PRAWNS; RED MANGROVES; SEAGRASS BEDS; FISH; ESTUARY;
CARBON
AB Coastal mangrove forests were historically considered as a source of organic matter (OM) for adjacent marine systems due to high net primary production; yet recent research suggesting little uptake through the food web because of low nutritional quality, challenges the concept of trophic linkage between mangrove forests and coral reefs. To examine the importance of mangrove forests to coral reef nutrient availability, we examined sessile reef-forming invertebrate consumers including hard corals, sponges, a bivalve mollusc, polychaete annelid and tunicate, and potential sources of OM (decaying mangrove leaves, microalgae, macroalgae, and seagrass) in Bocas del Toro, Panama. Using stable isotope analyses of delta S-34 and delta C-13 and a concentration-dependent version of the IsoSource mixing model, we were able to discriminate among and determine the range of potential contributions of our four OM sources to consumers. Contributions of microalgae and macroalgae were often indeterminate due to high variability, yet seagrass and mangrove contributions were often substantial. Mangrove OM ranged across sites and species of filter feeders from 0 to 57%, 7 to 41%, and 18 to 52% for sponges, file clams, and feather duster worms, respectively. Mangrove contribution to corals (Acropora cervicornis, Agaricia fragilis, Agaricia tenuifolia, Montastrea annularis, Diploria sp.) ranged from 0 to 44%. To examine whether OM contribution varied with distance from mangroves, we conducted a sponge transplant experiment that demonstrated declining mangrove contribution across three sponge species with increasing distance from the shore. These results supported the hypothesis of mangrove-coral reef nutrient linkages, providing the first evidence that mangrove inputs of OM to sessile invertebrates are substantial, accounting for 0-57% of the composition.
C1 [Granek, Elise F.] Oregon State Univ, Dept Zool, Corvallis, OR 97331 USA.
[Granek, Elise F.] Portland State Univ, Portland, OR 97207 USA.
[Compton, Jana E.; Phillips, Donald L.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
RP Granek, EF (reprint author), Oregon State Univ, Dept Zool, Corvallis, OR 97331 USA.
EM graneke@pdx.edu
RI Phillips, Donald/D-5270-2011
FU Fulbright Fellowship; NSF-GRF; Oregon State University Aquaculture
Collaborative Research Support Program Fellowship; David and Lucile
Packard Foundation; Smithsonian Tropical Research
Institution-Supplemental Research Award; Anchor Environmental
Scholarship; OSU URISC and IURP Fellowships; Oregon State University
FX We thank C. Diaz, B. Fry, B. Griffis, R. Brooks, S. Silva, R. Doucett,
C. Kendall, S. Perez, V. Weis, and B. Hungate for their ideas,
suggestions, interpretations, and assistance with the sample processing.
We also thank K. Purcell, K. Frasier, N. Ehlers, A. Amat, and M. Brown
for their assistance in the lab and field. This manuscript was
significantly improved through discussions and input from V. Weis, B.
Menge, J. Lubchenco, J. Benstead, and two anonymous reviewers. Funding
for this study was provided by a Fulbright Fellowship, an NSF-GRF, an
Oregon State University Aquaculture Collaborative Research Support
Program Fellowship, The David and Lucile Packard Foundation, a
Smithsonian Tropical Research Institution-Supplemental Research Award,
an Anchor Environmental Scholarship, OSU URISC and IURP Fellowships, a
Department of Zoology Research Fellowship from Oregon State University,
and in-kind support from the USGS Menlo Park Laboratory and the US EPA
National Health and Environmental Effects Laboratory, Western Ecology
Division. This manuscript has been subjected to US EPA's peer and
administrative review, and it has been approved for publication as an
EPA document. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use.
NR 40
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U1 3
U2 43
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1432-9840
EI 1435-0629
J9 ECOSYSTEMS
JI Ecosystems
PD APR
PY 2009
VL 12
IS 3
BP 462
EP 472
DI 10.1007/s10021-009-9235-7
PG 11
WC Ecology
SC Environmental Sciences & Ecology
GA 424EC
UT WOS:000264547300009
ER
PT J
AU Glassmeyer, ST
Hinchey, EK
Boehme, SE
Daughton, CG
Ruhoy, IS
Conerly, O
Daniels, RL
Lauer, L
McCarthy, M
Nettesheim, TG
Sykes, K
Thompson, VG
AF Glassmeyer, Susan T.
Hinchey, Elizabeth K.
Boehme, Susan E.
Daughton, Christian G.
Ruhoy, Ilene S.
Conerly, Octavia
Daniels, Rebecca L.
Lauer, Lisa
McCarthy, Meg
Nettesheim, Todd G.
Sykes, Kathy
Thompson, Virginia G.
TI Disposal practices for unwanted residential medications in the United
States
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Pharmaceutical; Drugs; Medications; Discard; Disposal; Household
hazardous wastes; Unwanted
ID WASTE-WATER CONTAMINANTS; PROMOTING HUMAN HEALTH; TO-CRADLE STEWARDSHIP;
ENVIRONMENTAL DISPOSITION; PHARMACEUTICALS; DRUGS; TRANSPORT; STREAMS;
FISH; VULNERABILITY
AB The occurrence of trace levels of prescription and over-the-counter pharmaceuticals in the environment began to receive concerted attention nearly two decades ago. The public's growing awareness and concern over the presence of these chemicals, especially in drinking water. has served to catalyze considerable discussion and debate regarding the best practices for disposal of unused or unwanted medications. In the United States, the first federal guidance for consumers was issued in 2007. It recommends discarding unused pharmaceuticals to household trash. after taking precautions to mix the pharmaceuticals with an inert substance and conceal the contents from view. Providing the consumer with additional options for conscientious disposal are various community, city, and state collection events, ongoing programs, and government-funded pilot projects. These strategies include the opportunity to mail or bring unused medications to various collection points, such as pharmacies, for eventual destruction. All of these approaches to medication disposal play roles in reducing the introduction of pharmaceuticals to the environment. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Glassmeyer, Susan T.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Hinchey, Elizabeth K.] Purdue Univ, Illinois Indiana Sea Grant Coll Program, W Lafayette, IN 47907 USA.
[Boehme, Susan E.] Univ Illinois, Illinois Indiana Sea Grant Coll Program, Urbana, IL 61801 USA.
[Daughton, Christian G.; Ruhoy, Ilene S.] US EPA, Off Res & Dev, Las Vegas, NV 89119 USA.
[Conerly, Octavia] US EPA, Off Water, Washington, DC 20460 USA.
[Daniels, Rebecca L.] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Lauer, Lisa; McCarthy, Meg] US EPA, Off Solid Waste & Emergency Response, Washington, DC 20460 USA.
[Nettesheim, Todd G.] US EPA, Great Lakes Natl Program Off, Chicago, IL 60604 USA.
[Sykes, Kathy] US EPA, Off Administrator, Washington, DC 20460 USA.
[Thompson, Virginia G.] US EPA, Reg 3, Philadelphia, PA 19103 USA.
RP Glassmeyer, ST (reprint author), US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
EM glassmeyer.susan@epa.gov
RI Glassmeyer, Susan/E-5004-2017;
OI Glassmeyer, Susan/0000-0002-0538-5793; Daughton,
Christian/0000-0002-0302-7730
NR 42
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U1 3
U2 47
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
J9 ENVIRON INT
JI Environ. Int.
PD APR
PY 2009
VL 35
IS 3
BP 566
EP 572
DI 10.1016/j.envint.2008.10.007
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 432ZL
UT WOS:000265172900021
PM 19081631
ER
PT J
AU Samara, F
Gullett, BK
Harrison, RO
Chu, A
Clark, GC
AF Samara, Fatin
Gullett, Brian K.
Harrison, Robert O.
Chu, Andrew
Clark, George C.
TI Determination of relative assay response factors for toxic chlorinated
and brominated dioxins/furans using an enzyme immunoassay (EIA) and a
chemically-activated luciferase gene expression cell bioassay (CALUX)
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE PBDD/F; PCDD/F; PBCDD/F; CALUX; ELISA; Dioxin-like activity
ID DIOXIN-LIKE COMPOUNDS; POLYCHLORINATED-BIPHENYLS PCBS; EQUIVALENCY
FACTORS TEFS; DIBENZO-PARA-DIOXINS; FLAME RETARDANTS; P-DIOXINS;
RECEPTOR; SAMPLES; 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN;
2,3,7,8-TETRABROMODIBENZO-P-DIOXIN
AB Determination of toxic activity requires knowledge of both the concentration and toxicity to evaluate the risk for adverse human health and environmental effects. A chemically-activated luciferase gene expression cell bioassay system (CALUX) and an antibody-based method enzyme immunoassay (EIA) were used to detect the dioxin-like response of several polybrominated, polychlorinated, and polybrominated/chlorinated dibenzo-p-dioxins/furans (PBDDs/Fs, PCDDs/Fs, and PBCDDs/Fs, respectively). It has been suggested that the biological activity of the brominated and mixed bromo/chloro compounds is similar to their chlorinated analogues (measured by binding to the Ah receptor). PBDD/F, PCDD/F, and PBCDD/F laboratory standards exhibited biological activity ranging over three orders of magnitude. The highest relative potency (REP) values from CALUX analysis, when compared to 2,3,7,8-TCDD, were 2,3,7,8-TBDD at 0.99 (+/- 0.07), 1,2,3,7,8=PeCDD at 0.69, and 2-Br-3,7,8-TriCDD at 0.72 (+/- 0.02). Cross-reactivities were calculated using EIA for several PBDDs/Fs and PBCDDs. The highest percent cross-reactivity was found for 2,3,7,8-TBDD at 138 (+/- 34%), and 2,3,7-TriBDD at 84 (+/- 36%). Published by Elsevier Ltd.
C1 [Samara, Fatin; Gullett, Brian K.] US EPA, Off Res & Dev, Natl Risk Management Res Lab E305 01, Res Triangle Pk, NC 27711 USA.
[Harrison, Robert O.] Cape Technol, Portland, ME 04106 USA.
[Chu, Andrew; Clark, George C.] Xenobiot Detect Syst Inc, Durham, NC 27704 USA.
RP Gullett, BK (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab E305 01, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM gullett.brian@epa.gov
FU U.S. EPA, Research Triangle Park, NC; Xenobiotic Detection Systems,
Durham, NC
FX The authors of this paper would like to acknowledge Dennis Tabor (U.S.
EPA, Research Triangle Park, NC) and John Gordon (Xenobiotic Detection
Systems, Durham, NC) for their comments on the manuscript and help with
data analysis.
NR 31
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U1 3
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
J9 ENVIRON INT
JI Environ. Int.
PD APR
PY 2009
VL 35
IS 3
BP 588
EP 593
DI 10.1016/j.envint.2008.11.003
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 432ZL
UT WOS:000265172900024
PM 19121869
ER
PT J
AU Weisel, CP
Richardson, SD
Nemery, B
Aggazzotti, G
Baraldi, E
Blatchley, ER
Blount, BC
Carlsen, KH
Eggleston, PA
Frimmel, FH
Goodman, M
Gordon, G
Grinshpun, SA
Heederik, D
Kogevinas, M
LaKind, JS
Nieuwenhuijsen, MJ
Piper, FC
Sattar, SA
AF Weisel, Clifford P.
Richardson, Susan D.
Nemery, Benoit
Aggazzotti, Gabriella
Baraldi, Eugenio
Blatchley, Ernest R., III
Blount, Benjamin C.
Carlsen, Kai-Hakon
Eggleston, Peyton A.
Frimmel, Fritz H.
Goodman, Michael
Gordon, Gilbert
Grinshpun, Sergey A.
Heederik, Dirk
Kogevinas, Manolis
LaKind, Judy S.
Nieuwenhuijsen, Mark J.
Piper, Fontaine C.
Sattar, Syed A.
TI Childhood Asthma and Environmental Exposures at Swimming Pools: State of
the Science and Research Recommendations
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
DE aerosols; biologics; childhood asthma; DBPs; disinfection by-products;
epidemiology; study design; swimming pools
ID EXERCISE-INDUCED ASTHMA; DISINFECTION BY-PRODUCTS; BRONCHIAL
RESPONSIVENESS; RESPIRATORY SYMPTOMS; INDUCED BRONCHOCONSTRICTION;
AIRWAY INFLAMMATION; CHLORINATED POOL; ELITE SWIMMERS; LUNG-FUNCTION;
CHILDREN
AB OBJECTIVES: Recent studies have explored the potential for swimming pool disinfection by-products (DBPS), which are respiratory irritants, to cause asthma in young children. Here we describe the state of the science on methods for understanding children's exposure to DBPs and biologics at swimming pools and associations with new-onset childhood asthma and recommend a research agenda to improve our understanding of this issue.
DATA SOURCES: A workshop was held in Leuven, Belgium, 21-23 August 2007, to evaluate the literature and to develop a research agenda to better understand children's exposures in the swimming pool environment and their potential associations with new-onset asthma. Participants, including clinicians, epidemiologists, exposure scientists, pool operations experts, and chemists, reviewed the literature, prepared background summaries, and held extensive discussions on the relevant published studies, knowledge of asthma characterization and exposures at swimming pools, and epidemiologic study designs.
SYNTHESIS: Childhood swimming and new-onset childhood asthma have clear implications for public health. If attendance at indoor pools increases risk of childhood asthma, then concerns are warranted and action is necessary. If there is no such relationship, these concerns could unnecessarily deter children from indoor swimming and/or compromise water disinfection.
CONCLUSIONS: Current evidence of an association between childhood swimming and new-onset asthma is suggestive but not conclusive. Important data gaps need to be filled, particularly in exposure assessment and characterization of asthma in the very young. Participants recommended that additional evaluations using a multidisciplinary approach are needed to determine whether a dear association exists.
C1 [Weisel, Clifford P.] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08854 USA.
[Richardson, Susan D.] US EPA, Natl Exposure Res Lab, Athens, GA USA.
[Nemery, Benoit] Catholic Univ Leuven, Res Unit Lung Toxicol, Lab Pneumol, Louvain, Belgium.
[Aggazzotti, Gabriella] Univ Modena & Reggio Emilia, Dipartimento Sci Sanita Pubbl, Modena, Italy.
[Baraldi, Eugenio] Univ Padua, Dept Pediat, Unit Allergy & Resp Med, Padua, Italy.
[Blatchley, Ernest R., III] Purdue Univ, Sch Civil Engn, W Lafayette, IN 47907 USA.
[Blount, Benjamin C.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
[Carlsen, Kai-Hakon] Univ Oslo, Norwegian Sch Sport Sci, Fac Med, Oslo, Norway.
[Eggleston, Peyton A.] Johns Hopkins Univ, Baltimore, MD USA.
[Frimmel, Fritz H.] Univ Karlsruhe, Engler Bunte Inst, Dept Water Chem, D-7500 Karlsruhe, Germany.
[Goodman, Michael] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
[Gordon, Gilbert] Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA.
[Grinshpun, Sergey A.] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH USA.
[Heederik, Dirk] Univ Utrecht, Netherlands Inst Risk Assessment Sci, Div Environm & Occupat Hlth, Utrecht, Netherlands.
[Kogevinas, Manolis] Ctr Res Environm Epidemiol, Barcelona, Spain.
[Kogevinas, Manolis] Municipal Inst Med Res IMIM Hosp Mar, Barcelona, Spain.
[Kogevinas, Manolis] Univ Crete, Sch Med, Iraklion, Greece.
[LaKind, Judy S.] LaKind Associates LLC, Catonsville, MD USA.
[Nieuwenhuijsen, Mark J.] Parc Recerca Biomed Barcelona, Environm Epidemiol, Barcelona, Spain.
[Piper, Fontaine C.] Truman State Univ, Educ Comm Natl Swimming Pool Fdn, Bushkill, PA USA.
[Sattar, Syed A.] Univ Ottawa, Fac Med, Ctr Res Environm Microbiol, Ottawa, ON, Canada.
RP Weisel, CP (reprint author), Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Environm & Occupat Hlth Sci Inst, Room 314,170 Frelinghuysen Rd, Piscataway, NJ 08854 USA.
EM weisel@eohsi.rutgers.edu
RI Aggazzotti, Gabriella/P-5046-2015; Nieuwenhuijsen, Mark/C-3914-2017;
Kogevinas, Manolis/C-3918-2017;
OI Aggazzotti, Gabriella/0000-0002-2497-9941; Nieuwenhuijsen,
Mark/0000-0001-9461-7981; BARALDI, EUGENIO/0000-0002-1829-3652
FU World Chlorine Council; DuPont Experimental Station; National Swimming
Pool Foundation; American Chemistry Council
FX All participants received support for travel and/or lodging, and C.P.W.,
G.A., E.B., E.R.B., K.-H.C., P.A.E., F.H.F., M.G., G.G., S.G., D.H.,
F.C.P., and S.S. also received an honorarium. The Research Unit of Lung
Toxicology of the Catholic University of Leuven received an honorarium,
and J.S.L. received support for her role as workshop facilitator firm
the Research foundation for Health and Environment, and consults to
industry and government. E.R.B. has received grants for research on
swimming pool chemistry from DuPont Experimental Station, the National
Swimming Pool Foundation, and the American Chemistry Council. S.A.S.'s
academic center receives research contracts from makers of environmental
surface disinfectants and hand antiseptics; he advises many such
companies through his company Canlinks International, and is on the
board of directors of Virox Tech. The other authors declare they have no
competing financial interests.
NR 86
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PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD APR
PY 2009
VL 117
IS 4
BP 500
EP 507
DI 10.1289/ehp.11513
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 426JQ
UT WOS:000264704500021
PM 19440486
ER
PT J
AU Villeneuve, DL
Mueller, ND
Martinovic, D
Makynen, EA
Kahl, MD
Jensen, KM
Durhan, EJ
Cavallin, JE
Bencic, D
Ankley, GT
AF Villeneuve, Daniel L.
Mueller, Nathaniel D.
Martinovic, Dalma
Makynen, Elizabeth A.
Kahl, Michael D.
Jensen, Kathleen M.
Durhan, Elizabeth J.
Cavallin, Jenna E.
Bencic, David
Ankley, Gerald T.
TI Direct Effects, Compensation, and Recovery in Female Fathead Minnows
Exposed to a Model Aromatase Inhibitor
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE adaptation; endocrine disruption; estradiol; fadrozole; fish; gene
expression; reproduction; steroid biosynthesis; vitellogenin
ID FOLLICLE-STIMULATING-HORMONE; MESSENGER-RNA EXPRESSION;
PIMEPHALES-PROMELAS; REPRODUCTIVE TOXICITY; FISH GONADOTROPINS;
OVARIAN-FOLLICLES; SUBUNIT GENES; PAGRUS-MAJOR; RED SEABREAM; IN-VITRO
AB BACKGROUND: Several chemicals in the environment have the potential to inhibit aromatase, an enzyme critical to estrogen synthesis.
OBJECTIVES: The objective of this study was to provide a detailed characterization of molecular and biochemical responses of female fathead minnows to a model aromatase inhibitor, fadrozole (FAD).
METHODS: Fish here exposed via water to 0, 3, or 30 mu g FAD/L for 8 days and then held in clean water for 8 days, with samples collected at four time points during each 8-day period. We quantified ex vivo steroid production, plasma steroids, and plasma vitellogenin (Vtg) concentrations and analyzed relative transcript abundance of 10 key regulatory genes in ovaries and 3 in pituitary tissue by real-time polymerase chain reaction.
RESULTS: Ex vivo 17 beta-estradiol (E-2) production and plasma E-2 and Vtg concentrations were significantly reduced after a single day of exposure to 3 mu g or 30 mu g FAD/L. However, plasma E-2 concentrations recovered by the eighth day of exposure in the 3-mu g/L group and within 1 day of cessation of exposure in the 30-mu g/L group, indicating concentration- and time-dependent physiologic compensation and recovery. Concentration-dependent increases in transcripts coding for aromatase (A isoform), cytochrome P450 side-chain cleavage, steroidogenic acute regulator), protein, and follicle-stimulating hormone receptor all coincided with increased E-2 production and recovery of plasma E-2 concentrations.
CONCLUSIONS: Results of this research highlight the need to consider compensation/adaptation and recovery when developing and interpreting short-term bioassays or biomarkers or when trying to predict the effects of chemical exposures based on mode of action.
C1 [Villeneuve, Daniel L.; Mueller, Nathaniel D.; Martinovic, Dalma; Makynen, Elizabeth A.; Kahl, Michael D.; Jensen, Kathleen M.; Durhan, Elizabeth J.; Cavallin, Jenna E.; Ankley, Gerald T.] US EPA, Midcontinent Ecol Div, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Duluth, MN 55804 USA.
[Bencic, David] US EPA, Off Res & Dev, Natl Exposure Res Lab, Ecol Exposure Res Div, Cincinnati, OH 45268 USA.
RP Villeneuve, DL (reprint author), US EPA, Midcontinent Ecol Div, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM villeneuve.dan@epa.gov
RI Mueller, Nathaniel/E-5864-2010
FU U.S. EPA; National Center for Computational Toxicology
FX This work was supported in part by the U.S. EPA, National Center for
Computational Toxicology.
NR 41
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U2 20
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD APR
PY 2009
VL 117
IS 4
BP 624
EP 631
DI 10.1289/ehp.11891
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 426JQ
UT WOS:000264704500038
PM 19440503
ER
PT J
AU Burke, TA
Dominici, F
Fox, M
White, RH
Cote, I
Hattis, DB
Samet, JM
White, PD
Zeise, L
AF Burke, Thomas A.
Dominici, Francesca
Fox, Mary
White, Ronald H.
Cote, Ila
Hattis, Dale B.
Samet, Jonathan M.
White, Paul D.
Zeise, Lauren
TI Linear Low-Dose Extrapolation for Noncancer Responses Is Not Generally
Appropriate Response
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Letter
ID RISK-ASSESSMENT; AIR-POLLUTION
C1 [Burke, Thomas A.; Dominici, Francesca; Fox, Mary; White, Ronald H.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Cote, Ila] US EPA, Res Triangle Pk, NC 27711 USA.
[Hattis, Dale B.] Clark Univ, Worcester, MA 01610 USA.
[Samet, Jonathan M.] Univ So Calif, Los Angeles, CA USA.
[White, Paul D.] US EPA, Washington, DC 20460 USA.
[Zeise, Lauren] Calif Environm Protect Agcy, Sacramento, CA USA.
RP Burke, TA (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
EM rwhite@jhsph.edu
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U1 0
U2 2
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD APR
PY 2009
VL 117
IS 4
BP A142
EP A143
DI 10.1289/ehp.0800329R
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 426JQ
UT WOS:000264704500005
ER
PT J
AU Heberling, MT
Templeton, JJ
AF Heberling, Matthew T.
Templeton, Joshua J.
TI Estimating the Economic Value of National Parks with Count Data Models
Using On-Site, Secondary Data: The Case of the Great Sand Dunes National
Park and Preserve
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Travel cost model; On-site sampling; National Parks; Consumer surplus
ID MULTIPLE DESTINATION TRIPS; ENDOGENOUS STRATIFICATION; TRAVEL COST;
RECREATION; TRUNCATION; REGRESSION; VALUATION; BENEFITS; DEMAND
AB We estimate an individual travel cost model for Great Sand Dunes National Park and Preserve (GSD) in Colorado using on-site, secondary data. The purpose of the on-site survey was to help the National Park Service better understand the visitors of GSD; it was not intended for a travel cost model. Variables such as travel cost and income were estimated based on respondents' Zip Codes. Following approaches found in the literature, a negative binomial model corrected for truncation and endogenous stratification fit the data the best. We estimate a recreational benefit of U.S. $89/visitor/year or U.S. $54/visitor/24-h recreational day (in 2002 U.S. $). Based on the approach presented here, there are other data sets for national parks, preserves, and battlefields where travel cost models could be estimated and used to support National Park Service management decisions.
C1 [Heberling, Matthew T.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Sustainable Technol Div,Sustainable Environm Bran, Cincinnati, OH 45268 USA.
[Templeton, Joshua J.] US Dept Transportat, Econ & Ind Anal Div, Volpe Natl Transportat Syst Ctr, Cambridge, MA 02142 USA.
RP Heberling, MT (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Sustainable Technol Div,Sustainable Environm Bran, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM heberling.matt@epa.gov
OI Heberling, Matthew/0000-0003-1120-612X
FU National Academy of Sciences, National Research Council
FX We would like to thank James Gramann, Art Hutchinson, Fred Bunch, Daniel
Stynes, Margaret Littlejohn, David Vollmer, Lena Le, and Megan McBride
for their helpful comments related to the NPS, GSD, VSP, and use of the
VSP data sets. We also acknowledge Roberto Martinez-Espineira for
providing insight into estimation of count data models corrected for
truncation and endogenous stratification. We thank the anonymous
referees for their constructive comments on the manuscript. Any errors
are those of the present authors. Joshua Templeton would like to
acknowledge that part of this research was conducted under a
postdoctoral research associateship provided by the National Academy of
Sciences, National Research Council. The views expressed herein are
strictly the opinions of the authors and in no manner represent or
reflect current or planned policy by the federal agencies. Mention of
trade names or commercial products does not constitute endorsement or
recommendation for use.
NR 43
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U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
J9 ENVIRON MANAGE
JI Environ. Manage.
PD APR
PY 2009
VL 43
IS 4
BP 619
EP 627
DI 10.1007/s00267-008-9149-8
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 418UT
UT WOS:000264175600006
PM 18506513
ER
PT J
AU Stander, EK
Ehrenfeld, JG
AF Stander, Emilie K.
Ehrenfeld, Joan G.
TI Rapid Assessment of Urban Wetlands: Do Hydrogeomorphic Classification
and Reference Criteria Work?
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Wetlands; Urban; Denitrification; HGM; Reference standard
ID FUNCTIONAL ASSESSMENT; FORESTED WETLANDS; RIPARIAN ZONES; GROUNDWATER
NITRATE; WATER WETLANDS; STREAM-CHANNEL; NEW-JERSEY; MITIGATION;
URBANIZATION; DENITRIFICATION
AB The Hydrogeomorphic (HGM) functional assessment method is predicated on the ability of hydrogeomorphic wetland classification and visual assessment of alteration to provide reference standards against which functions in individual wetlands can be evaluated. The effectiveness of this approach was tested by measuring nitrogen cycling functions in forested wetlands in an urbanized region in New Jersey, USA. Fourteen sites represented three HGM classes and were characterized as "least disturbed reference" or "non-reference" based on initial visual assessment. Water table levels and in situ rates of net nitrogen mineralization, net nitrification, and denitrification were measured over one year in each site. Hydrological alterations, resulting in consistently low or flashy water table levels, were not correlated with a priori designations as reference and non-reference. Although the flat-riverine wetland class had lower net nitrification and higher denitrification rates than riverine or mineral flat wetland classes, this difference was attributable to the lack of hydrologically-altered wetlands in the flat-riverine class, and thus more consistently wet conditions. Within all HGM classes, a classification based on the long-term hydrological record that separated sites with "normal," saturated hydrology from those with "altered," drier hydrology, clearly distinguished sites with different nitrogen cycling function. Based on these findings, current practices for designating reference standard sites to judge wetland functions, at least in urbanized regions, are ineffective and potentially misleading. At least one year of hydrological monitoring data is suggested to classify wetlands into groups that have different nutrient cycling functions, particularly in urban landscapes.
C1 [Stander, Emilie K.] US EPA, Natl Risk Management Res Lab, Urban Watershed Management Branch, Edison, NJ 08837 USA.
[Stander, Emilie K.; Ehrenfeld, Joan G.] Rutgers State Univ, Dept Ecol Evolut & Nat Resources, Sch Biol & Environm Sci, New Brunswick, NJ 08901 USA.
RP Stander, EK (reprint author), US EPA, Natl Risk Management Res Lab, Urban Watershed Management Branch, 2890 Woodbridge Ave, Edison, NJ 08837 USA.
EM stander.emilie@epa.gov
FU USGS/NIWR [00HQR0088]; New Jersey Water Resources Research Institute;
EPA STAR Graduate Fellowship
FX The authors thank Robert Hamilton, IV, Dave Lewis, Manisha Patel, Dave
Berry, Ryan Sklar, Seth Davis, Ann Lang, Adira Rybandt, Tammy Gotsch,
and Kim Spiegel for assistance with field data collection and laboratory
analyses and Monica Palta for assistance with data analysis. We also
thank Peter Groffman, Tamar Barkay, and Wei-Xing Zhu for helpful
comments on earlier versions of this manuscript. Funding was provided by
USGS/NIWR Grant 00HQR0088 and the New Jersey Water Resources Research
Institute. E. Stander was also supported on an EPA STAR Graduate
Fellowship for a portion of this study. This document has been subjected
to the agency's peer and administrative review and approved for
publication. Use of trade, brand, or firm names in this report is for
identification purposes only and does not constitute endorsement by the
U. S. Environmental Protection Agency.
NR 73
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U2 23
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
J9 ENVIRON MANAGE
JI Environ. Manage.
PD APR
PY 2009
VL 43
IS 4
BP 725
EP 742
DI 10.1007/s00267-008-9211-6
PG 18
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 418UT
UT WOS:000264175600014
PM 18850244
ER
PT J
AU Barron, MG
Vivian, DN
Yee, SH
Santavy, DL
AF Barron, Mace G.
Vivian, Deborah N.
Yee, Susan H.
Santavy, Deborah L.
TI Methods to estimate solar radiation dosimetry in coral reefs using
remote sensed, modeled, and in situ data
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
DE Solar radiation; Dosimetry; Coral; Modeling; Attenuation
ID ULTRAVIOLET-RADIATION; PHOTOENHANCED TOXICITY
AB Solar irradiance has been increasingly recognized as an important determinant of bleaching in coral reefs, but measurements of solar radiation exposure within coral reefs have been relatively limited. Solar radiation dosimetry within multiple coral reef areas of South Florida was assessed using remote sensed, modeled, and measured values during a minor bleaching event during August 2005. Coral reefs in the Dry Tortugas and Upper Keys had similar diffuse downwelling attenuation coefficients (Kd, m(-1)), whereas Kd values were significantly greater in the Middle and Lower Keys. Mean 1% attenuation depths varied by reef region for ultraviolet B (UVB; 9.7 to 20 m), ultraviolet A (UVA; 22 to 40 m) and visible (27 to 43 m) solar radiation. Solar irradiances determined from remote sensed data were significantly correlated with measured values, but were generally overestimated at the depth of corals. Solar irradiances modeled using an atmospheric radiative transfer model parameterized with site specific approximations of cloud cover showed close agreement with measured values. Estimated daily doses (W h/m(2)) of UVB (0.01-19), UVA (2-360) and visible (29-1,653) solar radiation varied with coral depth (2 to 24 m) and meteorological conditions. These results indicate large variation in solar radiation dosimetry within coral reefs that may be estimated with reasonable accuracy using regional Kd measurements and radiative transfer modeling.
C1 [Barron, Mace G.; Vivian, Deborah N.; Yee, Susan H.; Santavy, Deborah L.] US EPA, GED, Gulf Breeze, FL 32561 USA.
RP Barron, MG (reprint author), US EPA, GED, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM barron.mace@epa.gov
FU Dry Tortugas National Park [DRTO-2005- SCI-0010]; Florida Keys National
Marine Sanctuary [FKNMS-2003-050]
FX Thanks to the crew of the NOAA ship Nancy Foster for vessel support and
technical assistance, to Alex Almario and Peggy Harris for assistance
with solar radiation measurements, and to Steve Diamond for reviewing a
draft of the manuscript. This work was conducted under research permits
from Dry Tortugas National Park No. DRTO-2005- SCI-0010 and Florida Keys
National Marine Sanctuary no. FKNMS-2003-050. This manuscript is
contribution number 1305 of the Gulf Ecology Division of the US
Environmental Protection Agency Office of Research and Development's
National Health and Environmental Effects Research Laboratory, and has
been reviewed according to policy, but the information in this document
does not necessarily reflect the views and policies of the US EPA.
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PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD APR
PY 2009
VL 151
IS 1-4
BP 445
EP 455
DI 10.1007/s10661-008-0288-4
PG 11
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 413ZD
UT WOS:000263832800043
PM 18581248
ER
PT J
AU Shinyashiki, M
Eiguren-Fernandez, A
Schmitz, DA
Di Stefano, E
Li, N
Linak, WP
Cho, SH
Froines, JR
Cho, AK
AF Shinyashiki, Masaru
Eiguren-Fernandez, Arantza
Schmitz, Debra A.
Di Stefano, Emma
Li, Ning
Linak, William P.
Cho, Seung-Hyun
Froines, John R.
Cho, Arthur K.
TI Electrophilic and redox properties of diesel exhaust particles
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Diesel exhaust particles; Electrophiles; Redox activity; Humic-like
substances; Dithiothreitol; GAPDH
ID AIRBORNE PARTICULATE MATTER; GROWTH-FACTOR RECEPTOR; OXIDATIVE STRESS;
GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; ULTRAFINE PARTICLES; CATALYZED
OXIDATION; SRM 1649A; QUINONES; CELLS; GENERATION
AB The adverse health effects of air pollutants have been associated with their redox and electrophilic properties. Although the specific chemical species involved in these effects are not known, the characterization of their general physical and chemical properties is important to our understanding of the mechanisms by which they cause health problems. This manuscript describes results of a study examining the partition properties of these activities in aqueous and organic media. The water and dichloromethane (DCM) solubility of redox active and electrophilic constituents of seven diesel exhaust particle (DEP) samples were determined with assays developed earlier in this laboratory. The constituents exhibiting redox activity, which included both metals and nonmetal species, were associated with the particles in the aqueous suspensions. Portions of the redox active compounds were also DCM-soluble. In contrast, the electrophilic constituents included both water-soluble and DCM-soluble species. The role of quinones or quinone-like compounds in redox and electrophilic activities of the DCM-soluble constituents was assessed by reductive acetylation, a procedure that inactivates quinones. The results from this experiment indicated that most of the activities in the organic extract were associated with quinone-like substances. The partition properties of the reactive species are important in exposure assessment since the toxicokinetics of particles and solutes are quite distinct. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Froines, John R.; Cho, Arthur K.] Univ Calif Los Angeles, Dept Environm Hlth Sci, Sch Publ Hlth, Los Angeles, CA 90095 USA.
[Shinyashiki, Masaru; Eiguren-Fernandez, Arantza; Schmitz, Debra A.; Di Stefano, Emma; Froines, John R.] Univ Calif Los Angeles, Sch Publ Hlth, Ctr Occupat & Environm Hlth, Los Angeles, CA 90095 USA.
[Li, Ning] David Geffen Sch Med, Dept Med, Div Nanomed, Los Angeles, CA 90095 USA.
[Linak, William P.; Cho, Seung-Hyun] US EPA, Natl Risk Management Res Lab, Air Pollut Technol Branch, Res Triangle Pk, NC 27711 USA.
[Shinyashiki, Masaru; Eiguren-Fernandez, Arantza; Schmitz, Debra A.; Di Stefano, Emma; Froines, John R.; Cho, Arthur K.] Univ Calif Los Angeles, Sch Publ Hlth, So Calif Particle Ctr, Los Angeles, CA 90095 USA.
[Cho, Seung-Hyun] ORISE, Oak Ridge, TN USA.
RP Cho, AK (reprint author), Univ Calif Los Angeles, Dept Environm Hlth Sci, Sch Publ Hlth, Box 951772,21-297 CHS, Los Angeles, CA 90095 USA.
EM Acho@mednet.ucla.edu
FU United States Environmental Protection Agency [CR-82805901]; Asthma and
Outdoor Air Quality Consortium of the South Coast Air Quality Management
District [040621]; Southern California Environmental Health Science
Consortium (SCEHSC) [5P30 ES07048]; NIEHS
FX Funding source: The research described in this article has been funded
in part by the United States Environmental Protection Agency through
Grant no. CR-82805901 to UCLA. While the EPA co-authors collected the
DEP samples under an approved quality assurance project plan, the
subsequent analyses have not been subjected to the Agency's required
peer and policy review. The contents of this article should not be
construed to represent Agency policy and no official endorsement should
be inferred, The work has also been supported by The Asthma and Outdoor
Air Quality Consortium of the South Coast Air Quality Management
District (Sponsor award no.: 040621), and by the Southern California
Environmental Health Science Consortium (SCEHSC) 5P30 ES07048 (funded by
NIEHS).
NR 32
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U1 1
U2 19
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
J9 ENVIRON RES
JI Environ. Res.
PD APR
PY 2009
VL 109
IS 3
BP 239
EP 244
DI 10.1016/j.envres.2008.12.008
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 426JT
UT WOS:000264704800006
PM 19200952
ER
PT J
AU Duirk, SE
Desetto, LM
Davis, GM
AF Duirk, Stephen E.
Desetto, Lisa M.
Davis, Gary M.
TI Transformation of Organophosphorus Pesticides in the Presence of Aqueous
Chlorine: Kinetics, Pathways, and Structure-Activity Relationships
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID CONTAINING S-TRIAZINES; NATURAL-WATERS; DEGRADATION; CHLORPYRIFOS;
OXIDATION; MECHANISMS; OZONATION; REMOVAL
AB The fate of organophosphorus (OP) pesticides in the presence of aqueous chlorine was investigated under simulated drinking water treatment conditions. Intrinsic rate coefficients were found for the reaction of hypochlorous acid (k(HOCl,OP)) and hypochlorite ion (k(OCl,OP)) for several OP pesticides. The reaction of hypochlorous acid (HOCl) with each OP pesticide was relatively rapid near neutral pH, k(HOCl,OP) = 0.86 - 3.56 x 10(6) M(-1)h(-1). HOCl reacts at the thiophosphate (P = S) moiety of the OP pesticide resuffing in the formation of the corresponding oxon (P = 0), which is more toxic than the parent pesticide. Hypochlorite ion (OCl(-)) was found not to oxidize OP pesticides but act like a nucleophile accelerating hydrolysis, k(OCl,OP) = 37.3-15 910 M(-1)h(-1). Both the k(HOCl,OP) and the k(OCl,OP) were found to correlate well with molecular descriptors within each subgroup of the OP pesticide class. A model was developed to predict the transformation of OP pesticides in the presence of aqueous chlorine. With hydrolysis rate coefficients, the transformation of OP pesticides under drinking water treatment conditions was found to be adequately predicted. The structure-activity relationships and model developed here could be used by risk assessors to determine exposure to OP pesticides and their transformation products in potable water.
C1 [Duirk, Stephen E.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Athens, GA 30605 USA.
RP Duirk, SE (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM duirk.stephen@epa.gov
NR 30
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U1 3
U2 27
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD APR 1
PY 2009
VL 43
IS 7
BP 2335
EP 2340
DI 10.1021/es802868y
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 427DI
UT WOS:000264759600033
PM 19452883
ER
PT J
AU Xu, Y
Hubal, EAC
Clausen, PA
Little, JC
AF Xu, Ying
Hubal, Elaine A. Cohen
Clausen, Per A.
Little, John C.
TI Predicting Residential Exposure to Phthalate Plasticizer Emitted from
Vinyl Flooring: A Mechanistic Analysis
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID SEMIVOLATILE ORGANIC-COMPOUNDS; INDOOR AIR; AIRBORNE PARTICLES;
DYNAMIC-BEHAVIOR; DUST; EMISSION; ENVIRONMENT; PVC; NICOTINE; CHAMBER
AB A two-room model is developed to estimate the emission rate of di-2-ethylhexyl phthalate (DEHP) from vinyl flooring and the evolving gas-phase and adsorbed surface concentrations in a realistic indoor environment Because the DEHP emission rate measured in a test chamber may be quite different from the emission rate from the same material in the indoor environment, the model provides a convenient means to predict emissions and transport in a more realistic setting. Adsorption isotherms for phthalates and plasticizers on interior surfaces, such as carpet, wood, dust, and human skin, are derived from previous field and laboratory studies. Log-linear relationships between equilibrium parameters and chemical vapor pressure are obtained. The predicted indoor air DEHP concentration at steady state is 0.15 mu g/m(3). Room I reaches steady state within about one year, while the adjacent room reaches steady state about three months later. Ventilation rate has a strong influence on DEHP emission rate while total suspended particle concentration has a substantial impact on gas-phase concentration. Exposure to DEHP via inhalation, dermal absorption, and oral ingestion of dust is evaluated. The model clarifies the mechanisms that govern the release of DEHP from vinyl flooring and the subsequent interactions with interior surfaces, airborne particles, dust, and human skin. Although further model development, parameter identification, and model validation are needed, our preliminary model provides a mechanistic framework that elucidates exposure pathways for phthalate plasticizers, and can most likely be adapted to predict emissions and transport of other semivolatile organic compounds, such as brominated flame retardants and biocides, in a residential environment.
C1 [Xu, Ying; Little, John C.] Virginia Tech, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA.
[Hubal, Elaine A. Cohen] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Clausen, Per A.] Natl Res Ctr Working Environm, New Technol Grp, DK-2100 Copenhagen, Denmark.
RP Little, JC (reprint author), Virginia Tech, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA.
EM jcl@vt.edu
RI Little, John/B-4154-2009; Lucas, Elizabeth/E-2733-2010;
OI Clausen, Per Axel/0000-0003-0217-6563
FU National Science Foundation [CBET 0504167]
FX Financial support was provided by the National Science Foundation (CBET
0504167). We thank Peter Egeghy at EPA's National Exposure Research
Laboratory for his assistance with the CTEPP database, and John Kissel,
Linsey Mart, Bill Nazaroff, and Charlie Weschler for their useful
comments on the draft manuscript. This paper has been subjected to U.S.
EPA Office of Research and Development review and approved for
publication.
NR 31
TC 63
Z9 65
U1 4
U2 63
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD APR 1
PY 2009
VL 43
IS 7
BP 2374
EP 2380
DI 10.1021/es801354f
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 427DI
UT WOS:000264759600039
PM 19452889
ER
PT J
AU Pinder, RW
Gilliam, RC
Appel, KW
Napelenok, SL
Foley, KM
Gilliland, AB
AF Pinder, Robert W.
Gilliam, Robert C.
Appel, K. Wyat
Napelenok, Sergey L.
Foley, Kristen M.
Gilliland, Alice B.
TI Efficient Probabilistic Estimates of Surface Ozone Concentration Using
an Ensemble of Model Configurations and Direct Sensitivity Calculations
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID AIR-QUALITY MODELS; PHOTOCHEMICAL MODEL; EMISSIONS; FORECAST
AB Because all models are a simplification of the phenomenon they aim to represent, it is often more useful to estimate the probability of an event rather than a single "best" model result. Previous air quality ensemble approaches have used computationally expensive simulations of separately developed modeling systems. We present an efficient method to generate ensembles with hundreds of members based on several structural configurations of a single air quality modeling system. We use the Decoupled Direct Method in three dimensions to directly calculate how ozone concentrations change as a result of changes in input parameters. The modeled probability estimate is compared to observations and is shown to have a high level of skill and improved resolution and sharpness. This approach can help resolve the practical limits of incorporating uncertainty estimation into deterministic air quality management modeling applications.
C1 [Pinder, Robert W.; Gilliam, Robert C.; Appel, K. Wyat; Napelenok, Sergey L.; Foley, Kristen M.; Gilliland, Alice B.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Pinder, RW (reprint author), US EPA, Natl Exposure Res Lab, USEPA Mail Drop E243-01, Res Triangle Pk, NC 27711 USA.
EM pinder.rob@epa.gov
RI Pinder, Robert/F-8252-2011; Napelenok, Sergey/I-7986-2014
OI Pinder, Robert/0000-0001-6390-7126; Napelenok,
Sergey/0000-0002-7038-7445
NR 24
TC 19
Z9 20
U1 0
U2 7
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD APR 1
PY 2009
VL 43
IS 7
BP 2388
EP 2393
DI 10.1021/es8025402
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 427DI
UT WOS:000264759600041
PM 19452891
ER
PT J
AU Garcia-Reyero, N
Villeneuve, DL
Kroll, KJ
Liu, L
Orlando, EF
Watanabe, KH
Sepulveda, MS
Ankley, GT
Denslow, ND
AF Garcia-Reyero, Natalia
Villeneuve, Daniel L. .
Kroll, Kevin J.
Liu, Li
Orlando, Edward F.
Watanabe, Karen H.
Sepulveda, Maria S.
Ankley, Gerald T. .
Denslow, Nancy D.
TI Expression Signatures for a Model Androgen and Antiandrogen in the
Fathead Minnow (Pimephales promelas) Ovary
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID PROSTATE-CANCER CELLS; GENE-EXPRESSION; MESSENGER-RNA; IN-VITRO;
TRANSCRIPTION; FLUTAMIDE; MICROARRAY; 17-BETA-TRENBOLONE;
STEROIDOGENESIS; ENDOCRINOLOGY
AB Trenbolone, an anabolic androgen, and flutamide, an antiandrogen, are prototypical model compounds for agonism and antagonism of the androgen receptor. We hypothesized that 48 h exposures of female fathead minnows (Pimephales promelas) to environmentally relevant concentrations of these chemicals would alter genes regulated by the androgen receptor and that a mixture of the two compounds would block the effects. Gene expression in the ovaries was analyzed using a fathead minnow-specific 22 000-gene microarray. Flutamide altered about twice the number of genes as trenbolone, most of which appeared to be through pathways not associated with the androgen receptor. A group of 70 genes, of which we could identify 37, were reciprocally regulated by trenbolone and flutamide. These are candidates for specific biomarkers for androgen receptor mediated gene expression. Four genes stand out as specifically related to reproduction: sperm associated antigen 8 (SPAG8), CASP8 and FADD-like apoptosis regulator (CFLAR), corticotropin releasing hormone (CRH), and 3 beta-hydroxysteroid dehydrogenases (3 beta-HSD). Three notable transcriptional regulators including myelocytomatosis viral oncogene homologue (MYC), Yin Yang 1 (YY1), and interferon regulator factor 1 (IRF1) may function as early molecular switches to control phenotypic changes in ovary tissue architecture and function in response to androgen or antiandrogen exposure.
C1 [Garcia-Reyero, Natalia; Denslow, Nancy D.] Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA.
[Garcia-Reyero, Natalia; Kroll, Kevin J.; Denslow, Nancy D.] Univ Florida, Ctr Environm & Human Toxicol, Gainesville, FL 32611 USA.
[Villeneuve, Daniel L. .; Ankley, Gerald T. .] US EPA, ORD, NHEERL, Med, Duluth, MN 55804 USA.
[Liu, Li] Univ Florida, ICBR, Gainesville, FL 32611 USA.
[Orlando, Edward F.] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA.
[Watanabe, Karen H.] Oregon Hlth & Sci Univ, Div Environm & Biomol Syst, Beaverton, OR 97006 USA.
[Sepulveda, Maria S.] Purdue Univ, Dept Forestry & Nat Resources, Lafayette, IN 47907 USA.
RP Denslow, ND (reprint author), Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA.
EM ndenslow@ufl.edu
RI Sepulveda, Maria/P-3598-2014
FU Environmental Protection Agency STAR; EPA [R831848]; Spanish Ministry of
Sciences and Technology [EX-2004-0986]; EPA National Cente
FX This work was supported by the Environmental Protection Agency STAR
grant, EPA (R831848), by a fellowship to N G-R from the Spanish Ministry
of Sciences and Technology (EX-2004-0986), and the EPA National Center
for Computational Toxicology. We Would like to thank E. Durban, K.
Jensen, M. Kahl, and E. Makyrien for expert help with the fathead minnow
exposures. N.D. holds equity in EcoArray, Inc., a company
commercializing the microarray technology. She may benefit ftom this
technology by receiving royalties and equity growth.
NR 39
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U1 1
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD APR 1
PY 2009
VL 43
IS 7
BP 2614
EP 2619
DI 10.1021/es8024484
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 427DI
UT WOS:000264759600076
PM 19452925
ER
PT J
AU Perron, MM
Burgess, RM
Ho, KT
Pelletier, MC
Friedman, CL
Cantwell, MG
Shine, JP
AF Perron, Monique M.
Burgess, Robert M.
Ho, Kay T.
Pelletier, Marguerite C.
Friedman, Carey L.
Cantwell, Mark G.
Shine, James P.
TI DEVELOPMENT AND EVALUATION OF REVERSE POLYETHYLENE SAMPLERS FOR MARINE
PHASE II WHOLE-SEDIMENT TOXICITY IDENTIFICATION EVALUATIONS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Sediment toxicity; Toxicity identification evaluations; Nonionic organic
contaminants; Polyethylene samplers
ID POLYCHLORINATED BIPHENYL CONGENERS; SEMIPERMEABLE-MEMBRANE DEVICES;
NONIONIC ORGANIC-CHEMICALS; ULVA-LACTUCA; PARTITION-COEFFICIENTS;
AMMONIA TOXICITY; PASSIVE SAMPLERS; CONTAMINANTS; TOXICANTS; HARBOR
AB Marine and estuarine sediments accumulate contaminants and act as a sink for a wide range of toxic chemicals. As a result, the sediments themselves can become a source of contamination. At sufficient levels, contaminated sediments can cause benthic impairments and toxicity to marine organisms. Among the wide range of contaminants, nonionic organic contaminants (NOCs) are a primary cause of toxicity in marine sediments. Toxicity identification evaluations (TIEs) are used to characterize and identify chemicals causing toxicity in effluents, interstitial waters, and whole sediments using whole-organism endpoints. Phase I whole-sediment TIE methods for NOCs exist, but the development of phase II TIE methods for NOCs is a current research challenge. In the present study, the use of reverse polyethylene samplers (RePES) for phase II methods is examined. Various RePES designs were evaluated in an experimental design study with NOC chemical solutions. Based on equilibration time and proximity of measured NOC water concentrations in the reconstituted system to theoretical concentrations, a nontriolein design with loading of chemical solutions on the inside of the polyethylene tubing was chosen as most effective. A partitioning study demonstrated NOCs partitioned between the RePES and water as well as between the water and air, as expected using this nontriolein RePES design. Finally, a sediment toxicity study comparing the nontriolein RePES to contaminant-spiked sediments was conducted. The nontriolein RePES design was capable of successfully recreating the toxicity and water concentrations observed with the intact sediments.
C1 [Perron, Monique M.; Shine, James P.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
[Burgess, Robert M.; Ho, Kay T.; Pelletier, Marguerite C.; Cantwell, Mark G.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Narragansett, RI 02882 USA.
[Friedman, Carey L.] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA.
RP Perron, MM (reprint author), Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, 677 Huntington Ave, Boston, MA 02115 USA.
EM mperron@hsph.harvard.edu
FU U. S. Environmental Protection Agency; Harvard School of Public Health
FX We would like to thank Helen Suh and Christopher Paciorek for their
advice and feedback. We would also like to thank Jonathan Serbst and
Stephan Ryba for their technical assistance. This research was funded,
in part, by a student services contract from the U. S. Environmental
Protection Agency as well as a toxicology training grant from Harvard
School of Public Health.
NR 36
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U1 3
U2 15
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD APR
PY 2009
VL 28
IS 4
BP 749
EP 758
DI 10.1897/08-229.1
PG 10
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 416ZS
UT WOS:000264044700008
PM 19006439
ER
PT J
AU Johns, SM
Kane, MD
Denslow, ND
Watanabe, KH
Orlando, EF
Villeneuve, DL
Ankley, GT
Sepulveda, MS
AF Johns, Sonia M.
Kane, Michael D.
Denslow, Nancy D.
Watanabe, Karen H.
Orlando, Edward F.
Villeneuve, Dan L.
Ankley, Gerald T.
Sepulveda, Maria S.
TI CHARACTERIZATION OF ONTOGENETIC CHANGES IN GENE EXPRESSION IN THE
FATHEAD MINNOW (PIMEPHALES PROMELAS)
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Endocrine disruption; Fathead minnow; Fish early life stages; Gene
expression; qPCR
ID GROWTH-FACTOR-I; EARLY-LIFE-STAGES; DANIO-RERIO; THYROID-HORMONE;
MOLECULAR CHARACTERIZATION; DEVELOPMENTAL EXPRESSION; VITELLOGENIN
GENES; MESSENGER-RNA; ZEBRAFISH; FISH
AB Recently, researchers have begun looking at changes in gene expression in the fathead minnow (Pimephales promelas) after contaminant exposure as a way to develop biomarkers of exposure and effects. However, the bulk of this research has been conducted on adults, with few studies focusing on early life stages. Expression of selected genes important in growth, development, and reproduction in teleosts was quantified by quantitative polymerase chain reaction during different developmental time periods (from 0 to 28 d postfertilization [dpf]). Over the developmental period studied, there was a significant up-regulation of growth hormone mRNA and no significant changes in the expression of insulin-like growth factor 1. Thyroid hormone receptors A and B were detected in 4 dpf embryos and their expression stayed relatively constant. The variation in cytochrome P45019A mRNA expression was large during the first week of development, returning to 0 dpf expression levels thereafter. Estrogen receptor 2B was up-regulated during the first three weeks postfertilization, returning to prehatch values by 28 dpf. Expression of hydroxysteroid dehydrogenase 3B and steroidogenic acute regulatory protein increased after the third or fourth week postfertilization, respectively. Vitellogenin exhibited a large degree of variation within time points, especially after day 15, and a significant up-regulation for this gene was observed at 7 and 10 dpf. Knowledge of the normal changes in gene expression during embryo and larval development will allow for better experimental design and selection of suitable biomarkers when testing the potential toxicological effects of contaminants in this model fish species.
C1 [Johns, Sonia M.; Sepulveda, Maria S.] Purdue Univ, Dept Forestry & Nat Resources, W Lafayette, IN 47906 USA.
[Kane, Michael D.] Purdue Univ, Dept Comp & Informat Technol, W Lafayette, IN 47906 USA.
[Denslow, Nancy D.] Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA.
[Denslow, Nancy D.] Univ Florida, Ctr Environm & Human Toxicol, Gainesville, FL 32611 USA.
[Watanabe, Karen H.] Oregon Hlth & Sci Univ, Dept Environm & Biomol Syst, Beaverton, OR 97006 USA.
[Orlando, Edward F.] Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA.
[Villeneuve, Dan L.; Ankley, Gerald T.] US EPA, Mid Continent Ecol Div, Duluth, MN 55804 USA.
RP Sepulveda, MS (reprint author), Purdue Univ, Dept Forestry & Nat Resources, W Lafayette, IN 47906 USA.
EM mssepulv@purdue.edu
RI Sepulveda, Maria/P-3598-2014
FU Department of Forestry and Natural Resources; Cooperative Agreement to
the University of Florida; Oregon Health and Science University; Purdue
University; Florida Atlantic University; U.S. EPA Science to Achieve
Results [RD-83184801-0]
FX We thank Bob Rode, laboratory manager for the aquatic research facility,
and many students (N. Barton, L. Henneberger, K. Ralston-Hopper, G.
Laban, B. Lowry, A. McAlexander, R. Morehouse, and B. Sanchez) for their
help with the maintenance of the fathead minnow colony. We also want to
thank the Department of Forestry and Natural Resources, Purdue
University, for supporting S. Johns with a research assistantship. This
research was supported in part by a Cooperative Agreement to the
University of Florida (N. D. Denslow); Oregon Health and Science
University (K. H. Watanabe); Purdue University (M. S. Sepulveda); and
Florida Atlantic University (E. F. Orlando); from the U.S. EPA Science
to Achieve Results program (STAR; Assistance Agreement RD-83184801-0).
The research described in this article does not necessarily reflect the
views of the U. S. EPA, and no official endorsement should be inferred.
NR 48
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U1 1
U2 12
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD APR
PY 2009
VL 28
IS 4
BP 873
EP 880
PG 8
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 416ZS
UT WOS:000264044700021
PM 19391683
ER
PT J
AU Knightes, CD
Sunderland, EM
Barber, MC
Johnston, JM
Ambrose, RB
AF Knightes, Christopher D.
Sunderland, Elsie M.
Barber, M. Craig
Johnston, John M.
Ambrose, Robert B., Jr.
TI APPLICATION OF ECOSYSTEM-SCALE FATE AND BIOACCUMULATION MODELS TO
PREDICT FISH MERCURY RESPONSE TIMES TO CHANGES IN ATMOSPHERIC DEPOSITION
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Models; Response times; Ecosystem; Mercury; Fish
ID WATER-QUALITY MODEL; ELEMENTAL MERCURY; NATURAL-WATERS; NEW-HAMPSHIRE;
CARSON RIVER; MASS-BALANCE; LAKES; METHYLATION; TRANSPORT; SEDIMENTS
AB Management strategies for controlling anthropogenic mercury emissions require understanding how ecosystems will respond to changes in atmospheric mercury deposition. Process-based mathematical models are valuable tools for informing such decisions, because measurement data often are sparse and cannot be extrapolated to investigate the environmental impacts of different policy options. Here, we bring together previously developed and evaluated modeling frameworks for watersheds, water bodies, and food web bioaccumulation of mercury. We use these models to investigate the timescales required for mercury levels in predatory fish to change in response to altered mercury inputs. We model declines in water, sediment, and fish mercury concentrations across five ecosystems spanning a range of physical and biological conditions, including a farm pond, a seepage lake, a stratified lake, a drainage lake, and a coastal plain river. Results illustrate that temporal lags are longest for watershed-dominated systems (like the coastal plain river) and shortest for shallow water bodies (like the seepage lake) that receive most of their mercury from deposition directly to the water surface. All ecosystems showed responses in two phases: A relatively rapid initial decline in mercury concentrations (20-60% of steady-state values) over one to three decades, followed by a slower descent lasting for decades to centuries. Response times are variable across ecosystem types and are highly affected by sediment burial rates and active layer depths in systems not dominated by watershed inputs. Additional research concerning watershed processes driving mercury dynamics and empirical data regarding sediment dynamics in freshwater bodies are critical for improving the predictive capability of process-based mercury models used to inform regulatory decisions.
C1 [Knightes, Christopher D.; Barber, M. Craig; Johnston, John M.; Ambrose, Robert B., Jr.] US EPA, Off Res & Dev, Ecosyst Res Div, Athens, GA 30605 USA.
[Sunderland, Elsie M.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
RP Knightes, CD (reprint author), US EPA, Off Res & Dev, Ecosyst Res Div, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM knightes.chris@epa.gov
RI Sunderland, Elsie/D-5511-2014
OI Sunderland, Elsie/0000-0003-0386-9548
FU U.S. Environmental Protection Agency
FX This paper has been reviewed in accordance with the U.S. Environmental
Protection Agency's peer and administrative review policies and approved
for publication. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use. Statements in this
publication reflect the authors' professional views and opinions and
should not be construed to represent any determination or policy of the
U.S. Environmental Protection Agency. C. D. Knightes and E. M.
Sunderland contributed equally to this work. We thank O. Russell Bullock
(U.S. EPA, Research Triangle Park, NC), Curtis Pollman (Frontier
Geosciences, Seattle, WA), Tim Wool (U.S. EPA Region 4, Atlanta, GA),
Lourdes Prieto (U.S. EPA, Office of Research and Development, Athens,
GA), and two anonymous reviewers.
NR 60
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U1 2
U2 52
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD APR
PY 2009
VL 28
IS 4
BP 881
EP 893
PG 13
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 416ZS
UT WOS:000264044700022
PM 19391686
ER
PT J
AU Gordon, CJ
AF Gordon, Christopher J.
TI A new method to quantify core temperature instability in rodents
SO FASEB JOURNAL
LA English
DT Meeting Abstract
C1 [Gordon, Christopher J.] US EPA, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2009
VL 23
MA 788.17
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
Topics; Cell Biology
GA V27OC
UT WOS:000208621500710
ER
PT J
AU Suter, GW
AF Suter, Glenn W., II
TI Causal inference for ecological impairments
SO FRONTIERS IN ECOLOGY AND THE ENVIRONMENT
LA English
DT Letter
C1 US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA.
RP Suter, GW (reprint author), US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA.
EM suter.glenn@epa.gov
NR 1
TC 0
Z9 0
U1 0
U2 3
PU ECOLOGICAL SOC AMER
PI WASHINGTON
PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA
SN 1540-9295
J9 FRONT ECOL ENVIRON
JI Front. Ecol. Environ.
PD APR
PY 2009
VL 7
IS 3
BP 129
EP 129
DI 10.1890/09.WB.009
PG 1
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 430GT
UT WOS:000264977600017
ER
PT J
AU Reif, M
Frohn, RC
Lane, CR
Autrey, B
AF Reif, Molly
Frohn, Robert C.
Lane, Charles R.
Autrey, Brad
TI Mapping Isolated Wetlands in a Karst Landscape: GIS and Remote Sensing
Methods
SO GISCIENCE & REMOTE SENSING
LA English
DT Article
ID GEOGRAPHICALLY ISOLATED WETLANDS; LAND-COVER CLASSIFICATION;
UNITED-STATES; TM DATA; IMAGERY; AREAS; SEGMENTATION; INFORMATION; INDIA
AB GIS and remote sensing (RS) techniques using Landsat ETM+ and object-oriented segmentation were developed to identify depressional isolated wetlands in a > 2,600 km(2) mixed land use area of north-central Florida, USA. Both the stand-alone RS method and the combined GIS/RS method were successful at identifying isolated wetlands > 0.20 ha. Combining the GIS and RS methods yielded producer and user accuracies ranging from 93 to 100% and 86 to 95%, respectively. The methods utilized successfully mapped isolated wetlands and could be used to address questions surrounding national estimates and areal distribution of isolated wetlands.
C1 [Reif, Molly; Frohn, Robert C.] US EPA, Dynam Corp, Cincinnati, OH 45268 USA.
[Lane, Charles R.; Autrey, Brad] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Reif, M (reprint author), Univ So Mississippi, Gulf Coast Geospatial Ctr, 1203 Broad Ave,Suite 1A, Gulfport, MS 39501 USA.
EM molly.reif@gcgcusm.org
RI CHEN, YU/F-8600-2011
FU United States Environmental Protection Agency through its Office of
Research and Development [EP-D-06-096]
FX The United States Environmental Protection Agency through its Office of
Research and Development partially funded and collaborated in the
research described here under contract number EP-D-06-096 to Dynamac
Corporation. It has been subjected to Agency review and approved for
publication. Justicia Rhodus, Environmental Science Editor with Dynamac
Corporation, performed document editing and formatting.
NR 47
TC 14
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U1 1
U2 30
PU BELLWETHER PUBL LTD
PI COLUMBIA
PA 8640 GUILFORD RD, STE 200, COLUMBIA, MD 21046 USA
SN 1548-1603
J9 GISCI REMOTE SENS
JI GISci. Remote Sens.
PD APR-JUN
PY 2009
VL 46
IS 2
BP 187
EP 211
DI 10.2747/1548-1603.46.2.187
PG 25
WC Geography, Physical; Remote Sensing
SC Physical Geography; Remote Sensing
GA 461PG
UT WOS:000267279700004
ER
PT J
AU Veron, DE
Weaver, CP
Veron, F
Foster, MJ
AF Veron, Dana E.
Weaver, Christopher P.
Veron, Fabrice
Foster, Michael J.
TI Stochastic Radiative Transfer on Modeled Cloud Fields
SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
LA English
DT Article
DE Clouds; stochastic radiative transfer (RT)
ID COMMUNITY CLIMATE MODEL; SOLAR-RADIATION; PARAMETERIZATION; VARIABILITY;
CCM3
AB Several efforts are currently underway to improve cloud-radiation parameterizations in Global Climate Models (GCMs) by incorporating statistical properties of the cloud field. Although some radiation parameterizations, which are already computationally costly, now incorporate subgrid scale variability in cloud properties, they are not yet capable of using this information in their calculations of the 3-D radiation fields. Before drastic changes are made to such algorithms to incorporate cloud-cloud radiation interactions, the impact of including realistic high-resolution cloud distributions on the shortwave fluxes should be assessed. This letter provides a framework for carrying out such assessments, including a new methodology that blends a stochastic radiative transfer model, high-resolution cloud fields from a mesoscale meteorological model, and a threshold and object identification technique applied to cloud water content fields. This process provides a link between the radiative fluxes calculated in GCMs, where clouds occur at a subgrid scale, and the highly resolved cloud fields in a regional climate model, which can provide cloud field statistics. Two case studies are described herein.
C1 [Veron, Dana E.; Veron, Fabrice] Univ Delaware, Coll Marine & Earth Studies, Newark, DE 19716 USA.
[Weaver, Christopher P.; Foster, Michael J.] Rutgers State Univ, Dept Environm Sci, New Brunswick, NJ 08901 USA.
[Weaver, Christopher P.] US EPA, Global Change Res Program, Washington, DC 20460 USA.
RP Veron, DE (reprint author), Univ Delaware, Coll Marine & Earth Studies, Newark, DE 19716 USA.
EM dveron@udel.edu
RI Weaver, Christopher/G-3714-2010; Veron, Fabrice/G-2505-2012;
OI Weaver, Christopher/0000-0003-4016-5451; Veron,
Fabrice/0000-0001-5514-9767
NR 25
TC 0
Z9 0
U1 0
U2 4
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA
SN 1545-598X
J9 IEEE GEOSCI REMOTE S
JI IEEE Geosci. Remote Sens. Lett.
PD APR
PY 2009
VL 6
IS 2
BP 184
EP 188
DI 10.1109/LGRS.2008.2007814
PG 5
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA 435XG
UT WOS:000265376000002
ER
PT J
AU Welch, LS
Anderson, HA
Balmes, J
Braun, L
Brody, A
Castleman, B
Davis, D
Dement, JM
Frank, A
Gochfeld, M
Goldstein, BD
Guzman, JR
Henderson, DW
Huff, J
Infante, PF
Ladou, J
Landrigan, PJ
Leigh, J
Levin, SM
Mulloy, KB
Michaels, D
Oliver, LC
Pepper, L
Rosenman, KD
Schwartz, BS
Silverstein, M
Sokas, RK
Takahashi, K
Takaro, TK
Teitelbaum, DT
Vojakovic, R
Watterson, A
AF Welch, Laura S.
Anderson, Henry A.
Balmes, John
Braun, Lundy
Brody, Arnold
Castleman, Barry
Davis, Devra
Dement, John M.
Frank, Arthur
Gochfeld, Michael
Goldstein, Bernard D.
Rodriguez Guzman, Julietta
Henderson, Douglas W.
Huff, James
Infante, Peter F.
LaDou, Joseph
Landrigan, Philip J.
Leigh, James
Levin, Stephen M.
Mulloy, Karen B.
Michaels, David
Oliver, L. Christine
Pepper, Lewis
Rosenman, Kenneth D.
Schwartz, Brian S.
Silverstein, Michael
Sokas, Rosemary K.
Takahashi, Ken
Takaro, Tim K.
Teitelbaum, Daniel Thau
Vojakovic, Robert
Watterson, Andrew
TI Research on Mesothelioma from Brake Exposure: Corporate Influence
Remains Relevant Concern
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
LA English
DT Letter
ID MALIGNANT MESOTHELIOMA; ASBESTOS EXPOSURE; LUNG-CANCER; MECHANICS; RISK
C1 [Welch, Laura S.] CPWR, Silver Spring, MD USA.
[Welch, Laura S.] George Washington Univ, Sch Publ Hlth & Hlth Sci, Washington, DC 20052 USA.
[Anderson, Henry A.] Wisconsin Div Publ Hlth, Madison, WI USA.
[LaDou, Joseph] Univ Calif San Francisco, Sch Med, Int Ctr Occupat Med, San Francisco, CA 94143 USA.
[Balmes, John] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
[Braun, Lundy] Brown Univ, Dept Pathol, Providence, RI 02912 USA.
[Braun, Lundy] Brown Univ, Dept Lab Med, Providence, RI 02912 USA.
[Braun, Lundy] Brown Univ, Dept Africana Studies, Providence, RI 02912 USA.
[Brody, Arnold] N Carolina State Univ, Dept Mol & Biomed Sci, Raleigh, NC 27695 USA.
[Davis, Devra] Univ Pittsburgh, Inst Canc, Ctr Environm Oncol, Pittsburgh, PA 15260 USA.
[Davis, Devra] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA.
[Dement, John M.] Duke Univ, Med Ctr, Dept Community & Family Med, Div Occupat & Environm Med, Durham, NC 27710 USA.
[Frank, Arthur] Drexel Sch Publ Hlth, Dept Environm & Occupat Hlth, Philadelphia, PA USA.
[Gochfeld, Michael] Rutgers State Univ, Robert Wood Johnson Med Sch, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08854 USA.
[Rodriguez Guzman, Julietta] Univ El Bosque, Bogota, Colombia.
[Henderson, Douglas W.] Flinders Univ S Australia, Adelaide, SA, Australia.
[Huff, James] Natl Inst Environm Hlth Sci, NIH, Res Triangle Pk, NC USA.
[Michaels, David] George Washington Univ, Sch Publ Hlth & Hlth Serv, Dept Environm & Occupat Hlth, Washington, DC USA.
[Levin, Stephen M.] Mt Sinai Sch Med, Dept Community & Prevent Med, New York, NY USA.
[Leigh, James] Univ Sydney, Sch Publ Hlth, Ctr Environm & Occupat Hlth, Sydney, NSW 2006, Australia.
[Levin, Stephen M.] Mt Sinai Hosp, Mt Sinai IJ Selikoff Ctr Occupat & Environm Med, New York, NY 10029 USA.
[Mulloy, Karen B.] Denver Hlth Ctr Occupat Safety & Hlth, Denver, CO USA.
[Oliver, L. Christine] Harvard Univ, Sch Med, Cambridge, MA 02138 USA.
[Oliver, L. Christine] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Pepper, Lewis] Boston Univ, Sch Publ Hlth, Boston, MA USA.
[Rosenman, Kenneth D.] Michigan State Univ, Dept Med, Div Occupat & Environm Med, E Lansing, MI 48824 USA.
[Schwartz, Brian S.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Silverstein, Michael] Univ Washington, Sch Publ Hlth & Community Med, Seattle, WA 98195 USA.
[Sokas, Rosemary K.] Univ Illinois, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Chicago, IL USA.
[Takahashi, Ken] Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, WHO Collaborating Ctr Occupat Hlth, Kitakyushu, Fukuoka 807, Japan.
[Takaro, Tim K.] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC V5A 1S6, Canada.
[Teitelbaum, Daniel Thau] Colorado Sch Mines, Golden, CO 80401 USA.
[Teitelbaum, Daniel Thau] Univ Colorado, Hlth Sci Ctr, Denver, CO USA.
[Vojakovic, Robert] Asbestos Dis Soc Australia Inc, Osborn Pk, Australia.
[Watterson, Andrew] Univ Stirling, Occupat & Environm Hlth Res Grp, Stirling FK9 4LA, Scotland.
RP Welch, LS (reprint author), CPWR, Silver Spring, MD USA.
NR 13
TC 2
Z9 2
U1 1
U2 5
PU ABEL PUBLICATION SERVICES
PI BURLINGTON
PA 1611 AQUINAS COURT, BURLINGTON, NC 27215 USA
SN 1077-3525
J9 INT J OCCUP ENV HEAL
JI Int. J. Occup. Environ. Health
PD APR-JUN
PY 2009
VL 15
IS 2
BP 234
EP 238
PG 5
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 448IV
UT WOS:000266257200014
ER
PT J
AU Jones, JW
Jarnagin, T
AF Jones, John W.
Jarnagin, Taylor
TI Evaluation of a Moderate Resolution, Satellite-Based Impervious Surface
Map Using an Independent, High-Resolution Validation Data Set
SO JOURNAL OF HYDROLOGIC ENGINEERING
LA English
DT Article
AB Given the relatively high cost of mapping impervious surfaces at regional scales, substantial effort is being expended in the development of moderate-resolution, satellite-based methods for estimating impervious surface area (ISA). To rigorously assess the accuracy of these data products high quality, independently derived validation data are needed. High-resolution data were collected across a gradient of development within the Mid-Atlantic region to assess the accuracy of National Land Cover Data (NLCD) Landsat-based ISA estimates. Absolute error (satellite predicted area-"reference area") and relative error [satellite (predicted area-"reference area")/"reference area"] were calculated for each of 240 sample regions that are each more than 15 Landsat pixels on a side. The ability to compile and examine ancillary data in a geographic information system environment provided for evaluation of both validation and NLCD data and afforded efficient exploration of observed errors. In a minority of cases, errors could be explained by temporal discontinuities between the date of satellite image capture and validation source data in rapidly changing places. In others, errors were created by vegetation cover over impervious surfaces and by other factors that bias the satellite processing algorithms. On average in the Mid-Atlantic region, the NLCD product underestimates ISA by approximately 5%. While the error range varies between 2 and 8%, this underestimation occurs regardless of development intensity. Through such analyses the errors, strengths, and weaknesses of particular satellite products can be explored to suggest appropriate uses for regional, satellite-based data in rapidly developing areas of environmental significance.
C1 [Jones, John W.] US Geol Survey, Eastern Geog Sci Ctr, Natl Ctr 521, Reston, VA USA.
[Jarnagin, Taylor] US EPA, Landscape Ecol Branch, ORD Natl Exposure Lab, Res Triangle Pk, NC 27711 USA.
RP Jones, JW (reprint author), US Geol Survey, Eastern Geog Sci Ctr, Natl Ctr 521, Reston, VA USA.
EM jwjones@usgs.gov; jarnagin.taylor@epa.gov
FU USGS Land Remote Sensing Program; USEPA
FX This research was funded by the USGS Land Remote Sensing Program and the
USEPA. Gail Winter's careful QA/QC of contractor, student, and Federal
Employee ISA delineations and the helpful efforts of several anonymous
reviewers are gratefully acknowledged.
NR 16
TC 9
Z9 9
U1 1
U2 7
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1084-0699
J9 J HYDROL ENG
JI J. Hydrol. Eng.
PD APR
PY 2009
VL 14
IS 4
BP 369
EP 376
DI 10.1061/(ASCE)1084-0699(2009)14:4(369)
PG 8
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 418LZ
UT WOS:000264151000010
ER
PT J
AU Li, S
Park, H
Trempus, CS
Gordon, D
King, LC
Cotsarelis, G
Morris, RJ
AF Li, S.
Park, H.
Trempus, C. S.
Gordon, D.
King, L. C.
Cotsarelis, G.
Morris, R. J.
TI Heterogeneity in mutant Ha-ras expression within cutaneous papillomas in
mice
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the Society-of-Investigative-Dermatology
CY MAY 06-09, 2009
CL Montreal, CANADA
SP Soc Investigat Dematol
C1 [Li, S.; Park, H.; Morris, R. J.] Columbia Univ, Dept Dermatol, New York, NY 10027 USA.
[Trempus, C. S.] NIEHS, Mol Toxicol Lab, Res Triangle Pk, NC 27709 USA.
[Gordon, D.] Rutgers, Dept Genet, Piscataway, NJ USA.
[King, L. C.] EPA, Res Triangle Pk, NC USA.
[Cotsarelis, G.] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0022-202X
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2009
VL 129
MA 161
BP S27
EP S27
PG 1
WC Dermatology
SC Dermatology
GA 430MU
UT WOS:000264994000159
ER
PT J
AU Persaud-Sawin, DA
Lightcap, S
Harry, GJ
AF Persaud-Sawin, Dixie-Ann
Lightcap, Samantha
Harry, G. Jean
TI Isolation of rafts from mouse brain tissue by a detergent-free method
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE lipid-rich compartments; Flotillin 1; liquid-disordered phase; membrane
ID RICH MEMBRANE DOMAINS; GPI-ANCHORED PROTEINS; MYELIN BASIC-PROTEIN;
LIPID RAFTS; CELL-SURFACE; SIGNAL-TRANSDUCTION; MICRODOMAINS;
CHOLESTEROL; CAVEOLAE; GANGLIOSIDES
AB Membrane rafts are rich in cholesterol and sphingolipids and have specific proteins associated with them. Due to their small size, their identification and isolation have proved to be problematic. Their insolubility in nonionic detergents, such as Triton-X 100, at 4 degrees C has been the most common means of isolation. However, detergent presence can produce artifacts or interfere with ganglioside distribution. The direction is therefore toward the use of detergent-free protocols. We report an optimized method of raft isolation from lipid-rich brain tissue using a detergent-free method. We compared this to Triton-X 100-based isolation along sucrose or Optiprep (TM) gradients using the following endpoints: low protein content, high cholesterol content, presence of Flotillin 1 (Flot1), and absence of transferrin receptor (TfR) proteins. These criteria were met in raft fractions isolated in a detergent-free buffer along a sucrose gradient of 5%/35%/42.5%. The use of optiprep gave less consistent results with respect to protein distribution. We demonstrate that clean raft fractions with minimal myelin contamination can be reproducibly obtained in the top three low-density fractions along a sucrose step gradient. Persaud-Sawin, D-A., S. Lightcap, and G. J. Harry. Isolation of rafts from mouse brain tissue by a detergent-free method. J. Lipid Res. 2009. 50: 759-767.
C1 [Persaud-Sawin, Dixie-Ann; Lightcap, Samantha; Harry, G. Jean] Natl Inst Environm Hlth Sci, Lab Mol Toxicol Neurotoxicol Grp, Res Triangle Pk, NC 27709 USA.
RP Persaud-Sawin, DA (reprint author), Natl Inst Environm Hlth Sci, Lab Mol Toxicol Neurotoxicol Grp, Res Triangle Pk, NC 27709 USA.
EM sawind@niehs.nih.gov
FU Intramural Research Program of the National Institutes of Health;
National Institute of Environmental Health Sciences [1Z01ES101623-05]
FX This research was supported by the Intramural Research Program of the
National Institutes of Health, National Institute of Environmental
Health Sciences under project # 1Z01ES101623-05.
NR 56
TC 24
Z9 25
U1 0
U2 6
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0022-2275
J9 J LIPID RES
JI J. Lipid Res.
PD APR
PY 2009
VL 50
IS 4
BP 759
EP 767
DI 10.1194/jlr.D800037-JLR200
PG 9
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 420IV
UT WOS:000264283800019
PM 19060326
ER
PT J
AU Linkov, I
Steevens, J
Adlakha-Hutcheon, G
Bennett, E
Chappell, M
Colvin, V
Davis, JM
Davis, T
Elder, A
Hansen, S
Hakkinen, PB
Hussain, SM
Karkan, D
Korenstein, R
Lynch, I
Metcalfe, C
Ramadan, AB
Satterstrom, FK
AF Linkov, Igor
Steevens, Jeffery
Adlakha-Hutcheon, Gitanjali
Bennett, Erin
Chappell, Mark
Colvin, Vicki
Davis, J. Michael
Davis, Thomas
Elder, Alison
Foss Hansen, Steffen
Hakkinen, Pertti Bert
Hussain, Saber M.
Karkan, Delara
Korenstein, Rafi
Lynch, Iseult
Metcalfe, Chris
Ramadan, Abou Bakr
Satterstrom, F. Kyle
TI Emerging methods and tools for environmental risk assessment,
decision-making, and policy for nanomaterials: summary of NATO Advanced
Research Workshop
SO JOURNAL OF NANOPARTICLE RESEARCH
LA English
DT Editorial Material
DE Nanomaterials; Risk assessment; Decision analysis; Regulatory policy;
Uncertainty analysis; Nanotechnology governance; Societal implications
ID CARBON NANOTUBES; NANOPARTICLES; NANOTECHNOLOGY; IDENTIFICATION;
NANOTOXICOLOGY; ULTRAFINE; PROTEINS; WATER
AB Nanomaterials and their associated technologies hold promising opportunities for the development of new materials and applications in a wide variety of disciplines, including medicine, environmental remediation, waste treatment, and energy conservation. However, current information regarding the environmental effects and health risks associated with nanomaterials is limited and sometimes contradictory. This article summarizes the conclusions of a 2008 NATO workshop designed to evaluate the wide-scale implications (e.g., benefits, risks, and costs) of the use of nanomaterials on human health and the environment. A unique feature of this workshop was its interdisciplinary nature and focus on the practical needs of policy decision makers. Workshop presentations and discussion panels were structured along four main themes: technology and benefits, human health risk, environmental risk, and policy implications. Four corresponding working groups (WGs) were formed to develop detailed summaries of the state-of-the-science in their respective areas and to discuss emerging gaps and research needs. The WGs identified gaps between the rapid advances in the types and applications of nanomaterials and the slower pace of human health and environmental risk science, along with strategies to reduce the uncertainties associated with calculating these risks.
C1 [Linkov, Igor] USA, Environm Lab, Corps Engineers, Brookline, MA 02446 USA.
[Steevens, Jeffery] USA, Erdc, Vicksburg, MS 39056 USA.
[Adlakha-Hutcheon, Gitanjali] Def Res & Dev Canada, Ottawa, ON K1A 0K2, Canada.
[Bennett, Erin] Intertox Inc, Salem, MA 01970 USA.
[Chappell, Mark] USA, Environm Lab, Corps Engineers, Vicksburg, MS 39056 USA.
[Colvin, Vicki] Rice Univ, ICON, Houston, TX 77005 USA.
[Davis, J. Michael] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Davis, Thomas] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada.
[Elder, Alison] Univ Rochester, Dept Environm Med, Rochester, NY 14610 USA.
[Foss Hansen, Steffen] Tech Univ Denmark, Dept Environm Engn, NanoDTU, DK-2800 Lyngby, Denmark.
[Davis, Thomas] Environm Canada, Montreal, PQ H3C 3J7, Canada.
[Hussain, Saber M.] USAF, Res Lab, Dayton, OH USA.
[Karkan, Delara] Hlth Canada, Ottawa, ON K1A 0L2, Canada.
[Korenstein, Rafi] Tel Aviv Univ, Marian Gertner Inst Med Nanosyst, Dept Physiol & Pharmacol, Fac Med, IL-69978 Tel Aviv, Israel.
[Lynch, Iseult] Univ Coll Dublin, Sch Chem & Chem Biol, Irish Ctr Colloid Sci & Biomat, Dublin 2, Ireland.
[Metcalfe, Chris] Trent Univ, Peterborough, ON K9J 7B8, Canada.
[Ramadan, Abou Bakr] Natl Egyptian Environm & Radiat Monitoring Networ, Nasr City 11672, Cairo, Egypt.
[Satterstrom, F. Kyle] Harvard Univ, Sch Engn & Appl Sci, Engn Sci Lab 224, Cambridge, MA 02138 USA.
[Bennett, Erin] Bioengn Grp, Salem, MA 01970 USA.
RP Linkov, I (reprint author), USA, Environm Lab, Corps Engineers, 83 Winchester St Suite 1, Brookline, MA 02446 USA.
EM Igor.Linkov@usace.army.mil; Jeffery.A.Steevens@us.army.mil;
Gitanjali.Adlakha-Hutcheon@drdc-rddc.gc.ca; ebennett@bioengineering.com;
Mark.a.chappell@usace.army.mil; colvin@rice.edu; Davis.Jmichael@epa.gov;
ta.davis@umontreal.ca; Alison_Elder@urmc.rochester.edu; sfh@er.dtu.dk;
berthakkinen@gmail.com; Saber.Hussain@wpafb.af.mil;
Delara_karkan@hc-sc.gc.ca; korens@post.tau.ac.il; iseult@fiachra.ucd.ie;
cmetcalfe@trentu.ca; ramadan58@yahoo.com; satterst@fas.harvard.edu
RI Davis, J Michael/B-3337-2009; Hakkinen, Pertti/G-4803-2016; Lynch,
Iseult/I-3915-2014
OI Hakkinen, Pertti/0000-0002-8295-9738; Lynch, Iseult/0000-0003-4250-4584
NR 42
TC 46
Z9 46
U1 3
U2 40
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1388-0764
J9 J NANOPART RES
JI J. Nanopart. Res.
PD APR
PY 2009
VL 11
IS 3
BP 513
EP 527
DI 10.1007/s11051-008-9514-9
PG 15
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 413MR
UT WOS:000263797700001
ER
PT J
AU Bruno, M
Moore, T
Nesnow, S
Ge, Y
AF Bruno, Maribel
Moore, Tanya
Nesnow, Stephen
Ge, Yue
TI Protein Carbonyl Formation in Response to Propiconazole-induced
Oxidative Stress
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE carbonylation; propiconazole; oxidative stress; protein oxidation
ID TRIAZOLE CONAZOLE FUNGICIDES; PYRUVATE-CARBOXYLASE; IONIZING-RADIATION;
ALZHEIMERS-DISEASE; PROTEOMIC ANALYSIS; OXIDIZED PROTEINS; EXPRESSION;
MICE; IDENTIFICATION; INCREASES
AB Propiconazole, a widely used fungicide, is hepatotoxic and hepatotumorigenic in mice. Previous genomic analysis of liver tissues from propiconazole-treated mice identified genes and pathways involved in oxidative stress, suggesting that oxidative stress may play a role in propiconazole-induced toxicity. To understand the contribution of oxidative stress on toxicity at the protein level, we developed an integrated approach for the systematic measurement of protein oxidation in the livers from propiconazole-treated mice. Liver protein carbonylation increased significantly after treatment with propiconazole, demonstrating propiconazole-associated induction of oxidative stress. Utilizing two-dimensional gel electrophoresis (2-DE), immunoblotting, and mass spectrometry, we identified 17 carbonylated proteins that were altered with varying intensities by propiconazole treatment. The potential effects of protein carbonylation on protein functions and cellular activities in the liver of propiconazole-treated mice were further investigated. A significant negative correlation between protein carbonylation and cytochrome c reductase activity was found. We conclude that glycolysis, mitochondrial respiratory chain, ATP production, amino acid metabolism, CO(2) hydration, cellular antioxidant defense and detoxification system, and tetra hydrobiopterin pathways are affected by oxygen radicals in the livers of propiconazole-treated mice. This study suggests a mode of propiconazole-induced toxicity in mouse liver which primarily involves oxidative damage to cellular proteins.
C1 [Bruno, Maribel; Moore, Tanya; Nesnow, Stephen; Ge, Yue] US EPA, Div Environm Carcinogenesis, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Ge, Y (reprint author), US EPA, Div Environm Carcinogenesis, Natl Hlth & Environm Effects Res Lab, B 143-06, Res Triangle Pk, NC 27711 USA.
EM Ge.yue@epa.gov
FU U.S. Environmental Protection Agency
FX We thank Barbara Collins and Drs. James Allen, Sheau-Fung Thai, Jeffrey
Ross, Julian Preston, and Doug Wolf for their very helpful comments on
this manuscript. We thank Keith Tarpley for formatting figures required
for manuscript submission. The information in this document has been
funded wholly (or in part) by the U.S. Environmental Protection Agency.
It has been subjected to review by the National Health and Environmental
Effects Research Laboratory and approved for publication. Approval does
not signify that the contents reflect the views of the Agency, nor does
mention of trade names or commercial products constitute endorsement or
recommendation for use.
NR 50
TC 30
Z9 31
U1 1
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
J9 J PROTEOME RES
JI J. Proteome Res.
PD APR
PY 2009
VL 8
IS 4
BP 2070
EP 2078
DI 10.1021/pr801061r
PG 9
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA 429NU
UT WOS:000264928200044
PM 19714882
ER
PT J
AU Barth, E
Herrmann, R
Dahling, T
Brenner, R
Wright, S
Clark, P
AF Barth, E.
Herrmann, R.
Dahling, T.
Brenner, R.
Wright, S.
Clark, P.
TI Evaluation of Airborne Endotoxin Concentrations Associated with
Management of a Crop Grown on Applied Biosolids
SO JOURNAL OF RESIDUALS SCIENCE & TECHNOLOGY
LA English
DT Article
ID BACTERIAL-ENDOTOXINS; REGROWTH; EXPOSURE; DUST
AB Public health concerns have been expressed regarding inhalation exposure associated with the application of biosolids on cropland, which is due to the potential aerosolization of microorganisms, cell wall products, volatile chemicals, and nuisance odors. Endotoxin is a component of the cell walls of Gram-negative bacteria and is likely present in many biosolids. The application of biosolids to cropland may result in an immediate exposure or a delayed exposure to these microbial agents, such as when the crops are harvested. Upwind and downwind airborne concentrations of endotoxin were compared among and within two adjacent established hayfields, one with and one without previously applied biosolids, during grass raking and bailing activities. The mean downwind concentration of airborne endotoxin was significantly higher than the mean upwind concentration at the site where biosolids had been previously applied. The mean downwind concentration of endotoxin was not significantly different than the mean upwind concentration at the control field where biosolids had not previously been applied. When comparing the mean concentrations of airborne endotoxin among the sites, significant main effects were noticed for wind direction and field type, and an interactive effect was noticed for direction and field type. It is not known if the increased mean concentration of endotoxin associated with the downwind air samples at the applied biosolids field were due to the residual biosolids that were previously applied or due to endotoxin associated with plant material. The results apply to this investigation only since there was no treatment replication of each type of field. The downwind endotoxin concentrations observed during the raking and bailing activities were lower than various health effects criteria that have been recommended for airborne endotoxin.
C1 [Barth, E.; Herrmann, R.; Dahling, T.; Brenner, R.; Wright, S.; Clark, P.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Barth, E (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM barth.ed@epa.gov
NR 28
TC 0
Z9 0
U1 0
U2 4
PU DESTECH PUBLICATIONS, INC
PI LANCASTER
PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA
SN 1544-8053
J9 J RESIDUALS SCI TECH
JI J. Residuals Sci. Technol.
PD APR
PY 2009
VL 6
IS 2
BP 61
EP 65
PG 5
WC Engineering, Environmental
SC Engineering
GA 491IN
UT WOS:000269572200001
ER
PT J
AU Tolaymat, T
Al-Abed, SR
Jegadeesan, G
AF Tolaymat, Thabet
Al-Abed, Souhail R.
Jegadeesan, G.
TI Impact of Bioreactor Landfill Leachate Quality on As, Cd, Pb and Zn
Leaching from Mine Residues
SO JOURNAL OF RESIDUALS SCIENCE & TECHNOLOGY
LA English
DT Article
ID CEMENTITIOUS WASTES; PROCESSING WASTE; RELEASE; LEAD
AB In this paper, leaching of heavy metals (As, Cd, Pb and Zn) from two different metal rich wastes, namely mineral processing waste (W2) and waste derived fertilizer (W1) in batch extraction tests (TCLP, SPLP and deionized water) is presented. In addition, extraction tests using bioreactor MSW landfill leachates were also performed and results compared to the standardized tests. It was observed that the W1 (commercially available as Ironite) failed the TCLP tests, with Pb extract concentration (7.3 mg/L) higher than the TC limit. On the other hand, the W2 passed the TCLP test. Significant differences in arsenic leaching from W1 in the SPLP and deionized water extraction tests, compared to the TCLP tests reiterated the fact that TCLP underestimated the leachability of arsenic. Batch extraction tests using MSW landfill leachates were also performed. Landfill leachates were sampled from conventional (dry-tomb) and bioreactor facultative landfills. Leaching results indicated that TCLP overestimated Cd and Pb leaching in landfills. A comparison of all the batch extraction tests showed that leaching of heavy metals showed high pH dependency, with increased leaching in the acidic region (SPLP and deionized water tests). It was also observed that the dissolved organic carbon content and the volatile fatty acid content regulated the amount of heavy metals leached.
C1 [Tolaymat, Thabet; Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Jegadeesan, G.] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA.
RP Tolaymat, T (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM tolaymat.thabet@epa.gov
OI Jegadeesan, Gautham/0000-0001-6526-3694
NR 20
TC 4
Z9 4
U1 0
U2 7
PU DESTECH PUBLICATIONS, INC
PI LANCASTER
PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA
SN 1544-8053
J9 J RESIDUALS SCI TECH
JI J. Residuals Sci. Technol.
PD APR
PY 2009
VL 6
IS 2
BP 89
EP 96
PG 8
WC Engineering, Environmental
SC Engineering
GA 491IN
UT WOS:000269572200005
ER
PT J
AU Isakov, V
Touma, JS
Burke, J
Lobdell, DT
Palma, T
Rosenbaum, A
Ozkaynak, H
AF Isakov, Vlad
Touma, Jawad S.
Burke, Janet
Lobdell, Danellet T.
Palma, Ted
Rosenbaum, Arlene
Ozkaynak, Haluk
TI Combining Regional- and Local-Scale Air Quality Models with Exposure
Models for Use in Environmental Health Studies
SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION
LA English
DT Article
ID POLLUTANT CONCENTRATIONS; TEMPORAL VARIABILITY; POPULATION EXPOSURES;
PARTICULATE MATTER; LOS-ANGELES; OUTDOOR; PARTICLES; MORTALITY;
EMISSIONS; CHILDREN
AB Population-based human exposure models predict the distribution of personal exposures to pollutants of outdoor origin using a variety of inputs, including air pollution concentrations; human activity patterns, such as the amount of time spent outdoors versus indoors, commuting, walking, and indoors at home; microenvironmental infiltration rates; and pollutant removal rates in indoor environments. Typically, exposure models rely upon ambient air concentration inputs from a sparse network of monitoring stations. Here we present a unique methodology for combining multiple types of air quality models (the Community Multi-Scale Air Quality [CMAQ] chemical transport model added to the AERMOD dispersion model) and linking the resulting hourly concentrations to population exposure models (the Hazardous Air Pollutant Exposure Model [HAPEM] or the Stochastic Human Exposure and Dose Simulation [SHEDS] model) to enhance estimates of air pollution exposures that vary temporally (annual and seasonal) and spatially (at census-block-group resolution) in an urban area. The results indicate that there is a strong spatial gradient in the predicted mean exposure concentrations near roadways and industrial facilities that can vary by almost a factor of 2 across the urban area studied. At the high end of the exposure distribution (95th percentile), exposures are higher in the central district than in the suburbs. This is mostly due to the importance of personal mobility factors whereby individuals living in the central area often move between microenvironments with high concentrations, as opposed to individuals residing at the outskirts of the city. Also, our results indicate 20-30% differences due to commuting patterns and almost a factor of 2 difference because of near-roadway effects. These differences are smaller for the median exposures, indicating the highly variable nature of the reflected ambient concentrations. In conjunction with local data on emission sources, microenvironmental. factors, and behavioral and socioeconomic characteristics, the combined source-to-exposure modeling methodology presented in this paper can improve the assessment of exposures in future community air pollution health studies.
C1 [Isakov, Vlad; Touma, Jawad S.; Burke, Janet; Ozkaynak, Haluk] US EPA, Natl Exposure Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Lobdell, Danellet T.] US EPA, Natl Hlth & Environm Effect Res, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Palma, Ted] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Rosenbaum, Arlene] ICF Int, San Francisco, CA USA.
RP Isakov, V (reprint author), US EPA, Natl Exposure Res Lab, Off Res & Dev, Mail Drop E243-04,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Isakov.Vlad@epa.gov
NR 46
TC 46
Z9 50
U1 5
U2 40
PU AIR & WASTE MANAGEMENT ASSOC
PI PITTSBURGH
PA ONE GATEWAY CENTER, THIRD FL, PITTSBURGH, PA 15222 USA
SN 1047-3289
J9 J AIR WASTE MANAGE
JI J. Air Waste Manage. Assoc.
PD APR
PY 2009
VL 59
IS 4
BP 461
EP 472
DI 10.3155/1047-3289.59.4.461
PG 12
WC Engineering, Environmental; Environmental Sciences; Meteorology &
Atmospheric Sciences
SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric
Sciences
GA 429OK
UT WOS:000264929800009
PM 19418820
ER
PT J
AU Kaufmann, PR
Larsen, DP
Faustini, JM
AF Kaufmann, Philip R.
Larsen, David P.
Faustini, John M.
TI BED STABILITY AND SEDIMENTATION ASSOCIATED WITH HUMAN DISTURBANCES IN
PACIFIC NORTHWEST STREAMS
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE streambed sediment; relative bed stability; sediment transport;
environmental indicators; rivers; streams; nonpoint source pollution;
monitoring; geomorphology; disturbance; textural fining; channel
morphology; land use; )
ID OREGON COAST RANGE; SURFACE TEXTURES; HYDRAULIC ROUGHNESS;
UNITED-STATES; CHANNEL; RIVERS; BUFFINGTON,JOHN,M.; HABITAT; EROSION;
MONTGOMERY,DAVID,R
AB To evaluate anthropogenic sedimentation in United States (U.S.) Pacific Northwest coastal streams, we applied an index of relative bed stability (LRBS*) to summer low flow survey data collected using the U.S. Environmental Protection Agency's Environmental Monitoring and Assessment Program field methods in a probability sample of 101 wadeable stream reaches. LRBS* is the log of the ratio of bed surface geometric mean particle diameter (D(gm)) to critical diameter (D*(cbf)) at bankfull flow, based on a modified Shield's criterion for incipient motion. We used a formulation of LRBS* that explicitly accounts for reductions in bed shear stress that result from channel form roughness due to pools and wood. LRBS* ranged from -1.9 to +0.5 in streams within the lower quartile of human riparian and basin disturbance, and was substantially lower (-4.2 to -1.1) in streams within the upper quartile of human disturbance. Modeling results suggest that the expected range of LRBS* in streams without human disturbances in this region might be generally between -0.7 and +0.5 in either sedimentary or volcanic lithology. However, streams draining relatively soft, erodible sedimentary lithology showed greater reductions in LRBS* associated with disturbance than did those having harder, more resistant volcanic (basalt) lithology with similar levels of basin and riparian disturbance. At any given level of disturbance, smaller streams had lower LRBS* than those with larger drainages. In sedimentary lithology (sandstone and siltstone), high-gradient streams had higher LRBS* than did low-gradient streams of the same size and level of human disturbance. High gradient streams in volcanic lithology, in contrast, had lower LRBS* than low-gradient streams of similar size and disturbance. Correlations between D(gm) and land disturbance were stronger than those observed between D*(cbf) and land disturbance. This pattern suggests that land use has augmented sediment supplies and increased streambed fine sediments in the most disturbed streams. However, we also show evidence that some of the apparent reductions in LRBS*, particularly in steep streams draining small volcanic drainages, may have resulted in part from anthropogenic increases in bed shear stress. The synoptic survey methods and designs we use appear adequate to evaluate regional patterns in bed stability and sedimentation and their general relationship to human disturbances. More precise field measurements of channel slope, cross-section geometry, and bed surface particle size would be required to use LRBS* in applications requiring a higher degree of accuracy and precision, such as site-specific assessments at individual streams.
C1 [Kaufmann, Philip R.] Off Res & Dev, Natl Hlth & Environm Effects Lab, Western Ecol Div, Corvallis, OR USA.
[Larsen, David P.] Pacific States Marine Fisheries Commiss, Corvallis, OR USA.
[Faustini, John M.] US EPA, Dept Fisheries & Wildlife, Corvallis, OR USA.
RP Kaufmann, PR (reprint author), Off Res & Dev, Natl Hlth & Environm Effects Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR USA.
EM kaufmann.phil@epa.gov
RI Faustini, John/A-8378-2009
FU USEPA
FX The research presented in this paper was undertaken at the USEPA's
Western Ecology Division of the National Health and Environmental
Effects Laboratory in Corvallis, Oregon, and was funded by the USEPA
through the Environmental Monitoring and Assessment Program (EMAP), its
Regional (R-EMAP) surveys, and a grant from the EPA Office of Water's
Regional Methods Initiative. Data were collected in cooperation with the
States of Washington and Oregon. We are grateful for the use of data
collected and made available to us through cooperation with Glen
Merritt, Rick Hafele, Mike Mulvey, Lil Herger, and Gretchen Hayslip. We
are also grateful to Curt Seeliger and Marlys Cappaert for data
management and validation and to Sue Pierson for map preparation. Jim
Omernik and Sandra Bryce provided insights into the interpretation of
lithology. We thank John Van Sickle, Alan Herlihy, David Peck, and
Colleen Birch-Johnson for advice on data analysis, and we are grateful
to John Stoddard, Steve Paulsen, Margaret Passmore, and Gretchen Hayslip
for funding and program support. We thank Dave Montgomery, John
Buffington, LeRoy Poff, Brian Bledsoe, and Bob Beschta for enlightening
discussions of sediment transport concepts, and Brian Bledsoe, Safa
Shirazi, and John Van Sickle for comments on an earlier draft. Our final
draft was greatly improved by heeding comments from Jim Pizzuto, Nira
Salant, and an anonymous reviewer. This paper has been subjected to
review by the National Health and Environmental Effects Research
Laboratory's Western Ecology Division and approved for publication.
Approval does not signify that the contents reflect the views of the
Agency, nor does mention of trade names or commercial products
constitute endorsement or recommendation for use.
NR 82
TC 22
Z9 23
U1 0
U2 18
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1093-474X
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD APR
PY 2009
VL 45
IS 2
BP 434
EP 459
DI 10.1111/j.1752-1688.2009.00301.x
PG 26
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA 424KA
UT WOS:000264564400013
ER
PT J
AU Nakano, H
Lin, KL
Yanagita, M
Charbonneau, C
Cook, DN
Kakiuchi, T
Gunn, MD
AF Nakano, Hideki
Lin, Kaifeng Lisa
Yanagita, Manabu
Charbonneau, Chantal
Cook, Donald N.
Kakiuchi, Terutaka
Gunn, Michael D.
TI Blood-derived inflammatory dendritic cells in lymph nodes stimulate
acute T helper type 1 immune responses
SO NATURE IMMUNOLOGY
LA English
DT Article
ID MICE LACKING EXPRESSION; STEADY-STATE; IN-VIVO; MONOCYTE RECRUITMENT;
AIRWAY INFLAMMATION; ADAPTIVE IMMUNITY; CHEMOKINES CCL19; ORGAN
CHEMOKINE; KNOCKOUT MICE; ANTIGEN
AB T helper type 1 (T(H)1)- polarized immune responses, which confer protection against intracellular pathogens, are thought to be initiated by dendritic cells (DCs) that enter lymph nodes from peripheral tissues. Here we found after viral infection or immunization, inflammatory monocytes were recruited into lymph nodes directly from the blood to become CD11c(+) CD11b(hi)Gr-1(+) inflammatory DCs, which produced abundant interleukin 12p70 and potently stimulated T(H)1 responses. This monocyte extravasation required the chemokine receptor CCR2 but not the chemokine CCL2 or receptor CCR7. Thus, the accumulation of inflammatory DCs and T(H)1 responses were much lower in Ccr2(-/-) mice, were preserved in Ccl2(-/-) mice and were relatively higher in CCL19-CCL21-Ser-deficient plt mutant mice, in which all other lymph node DC types were fewer in number. We conclude that blood-derived inflammatory DCs are important in the development of T(H)1 immune responses.
C1 [Nakano, Hideki; Yanagita, Manabu; Charbonneau, Chantal; Gunn, Michael D.] Duke Univ, Med Ctr, Div Cardiol, Dept Med, Durham, NC 27710 USA.
[Nakano, Hideki; Lin, Kaifeng Lisa; Gunn, Michael D.] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA.
[Nakano, Hideki; Cook, Donald N.] Natl Inst Environm Hlth Sci, Lab Resp Biol, NIH, Res Triangle Pk, NC USA.
[Kakiuchi, Terutaka] Toho Univ, Sch Med, Dept Immunol, Tokyo, Japan.
RP Gunn, MD (reprint author), Duke Univ, Med Ctr, Div Cardiol, Dept Med, Durham, NC 27710 USA.
EM michael.gunn@duke.edu
OI Gunn, Michael/0000-0003-4602-0667
FU National Institutes of Health [AI047262, HL085473]; Japanese Ministry of
Science and Technology [1579054, 14021121]; Duke Human Vaccine
Institute; Japan Health Sciences Foundation [KH51052]; Japan Society for
the Promotion of Science [10670606, 12670621]; Japan Society for the
Promotion of Science for Young Scientists; National Institute of
Environmental Health Sciences
FX We thank K. Nakano for technical assistance, and J. Whitesides, P.
McDermott and L. Olive for cell sorting. Supported by the National
Institutes of Health (AI047262 and HL085473 to M. D. G.), the Japanese
Ministry of Science and Technology (1579054 to H. N., and 14021121 to T.
K.), the Duke Human Vaccine Institute (H. N.), the Japan Health Sciences
Foundation (KH51052 to T. K.), the Japan Society for the Promotion of
Science (10670606, 12670621 to T. K.), the Japan Society for the
Promotion of Science for Young Scientists (M. Y.) and the intramural
branch of the National Institute of Environmental Health Sciences of the
National Institutes of Health.
NR 44
TC 177
Z9 177
U1 0
U2 6
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1529-2908
J9 NAT IMMUNOL
JI Nat. Immunol.
PD APR
PY 2009
VL 10
IS 4
BP 394
EP 402
DI 10.1038/ni.1707
PG 9
WC Immunology
SC Immunology
GA 422KE
UT WOS:000264425800013
PM 19252492
ER
PT J
AU Zibell, G
Unkruer, B
Pekcec, A
Hartz, AMS
Bauer, B
Miller, DS
Potschka, H
AF Zibell, Guido
Unkrueer, Bernadette
Pekcec, Anton
Hartz, Anika M. S.
Bauer, Bjoern
Miller, David S.
Potschka, Heidrun
TI Prevention of seizure-induced up-regulation of endothelial
P-glycoprotein by COX-2 inhibition
SO NEUROPHARMACOLOGY
LA English
DT Article
DE Epilepsy; Status epilepticus; P-glycoprotein; Pharmacoresistance;
Multidrug transporter; Cyclooxygenase-2
ID BLOOD-BRAIN-BARRIER; NECROSIS-FACTOR-ALPHA; TEMPORAL-LOBE EPILEPSY;
CELL-DEATH; CYCLOOXYGENASE-2 EXPRESSION; INTRACEREBRAL HEMORRHAGE;
ADMINISTRATION INCREASES; PILOCARPINE MODEL; ARACHIDONIC-ACID;
DRUG-RESISTANCE
AB In the epileptic brain, seizure activity induces expression of the blood-brain barrier efflux transporter, P-glycoprotein, thereby limiting brain penetration and therapeutic efficacy of antiepileptic drugs. We recently provided the first evidence that seizures drive P-glycoprotein induction through a pathway that involves glutamate-signaling through the NMDA receptor and cyclooxygenase-2 (COX-2). Based on these data, we hypothesized that selective inhibition of COX-2 could prevent seizure-induced P-glycoprotein up-regulation. In the present study, we found that the highly selective COX-2 inhibitors, NS-398 and indomethacin heptyl ester, blocked the glutamate-induced increase in P-glycoprotein expression and transport function in isolated rat brain capillaries. Importantly, consistent with this, the COX-2 inhibitor, celecoxib, blocked seizure-induced up-regulation of P-glycoprotein expression in brain capillaries of rats in vivo. To explore further the role of COX-2 in signaling P-glycoprotein induction, we analyzed COX-2 protein expression in capillary endothelial cells in brain sections from rats that had undergone pilocarpine-induced seizures and in isolated capillaries exposed to glutamate and found no change from control levels. However, in isolated rat brain capillaries, the COX-2 substrate, arachidonic acid, significantly increased P-glycoprotein transport activity and expression indicating that enhanced substrate flux to COX-2 rather than increased COX-2 expression drives P-glycoprotein up-regulation. Together, these results provide the first in vivo proof-of-principle that specific COX-2 inhibition may be used as a new therapeutic strategy to prevent seizure-induced P-glycoprotein up-regulation at the blood-brain barrier for improving pharmacotherapy of drug-resistant epilepsy. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Zibell, Guido; Unkrueer, Bernadette; Pekcec, Anton; Potschka, Heidrun] Univ Munich, Inst Pharmacol Toxicol & Pharm, D-80539 Munich, Germany.
[Hartz, Anika M. S.] Univ Minnesota, Sch Med, Dept Biochem & Mol Biol, Duluth, MN 55812 USA.
[Bauer, Bjoern] Univ Minnesota, Coll Pharm, Dept Pharmaceut Sci, Duluth, MN 55812 USA.
[Bauer, Bjoern] Natl Inst Environm Hlth Sci, Pharmacol Lab, NIH, Res Triangle Pk, NC USA.
RP Potschka, H (reprint author), Univ Munich, Inst Pharmacol Toxicol & Pharm, Koeniginstr 16, D-80539 Munich, Germany.
EM potschka@pharmtox.vetmed.uni-muenchen.de
OI Potschka, Heidrun/0000-0003-1506-0252; Gualtieri,
Fabio/0000-0002-4972-0039
FU German Research Foundation [681/4-1]; University of Minnesota GIA
[20919]; NIH; National Institute of Environmental Health Sciences
FX We thank Sylvia Notenboom and Christina Fuest for their excellent
technical assistance. This research was supported by the grant DFG PO
681/4-1 (to HP) from the German Research Foundation, by a University of
Minnesota GIA grant #20919 (to BB) and by the Intramural Research
Program of the NIH, National Institute of Environmental Health Sciences.
NR 31
TC 49
Z9 54
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD APR
PY 2009
VL 56
IS 5
BP 849
EP 855
DI 10.1016/j.neuropharm.2009.01.009
PG 7
WC Neurosciences; Pharmacology & Pharmacy
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 441MY
UT WOS:000265774500002
PM 19371577
ER
PT J
AU Mayer, PM
Smith, LM
Ford, RG
Watterson, DC
McCutchen, MD
Ryan, MR
AF Mayer, Paul M.
Smith, Levica M.
Ford, Robert G.
Watterson, Dustin C.
McCutchen, Marshall D.
Ryan, Mark R.
TI Nest construction by a ground-nesting bird represents a potential
trade-off between egg crypticity and thermoregulation
SO OECOLOGIA
LA English
DT Article
DE Anti-predation; Charadrius melodus; Egg crypsis; Nest construction;
Thermoregulation
ID PIPING PLOVER NESTS; ADAPTIVE SIGNIFICANCE; SEXUAL SELECTION; KENTISH
PLOVERS; SITE SELECTION; HEAT-LOSS; PREDATION; COLOR; INCUBATION;
CRYPSIS
AB Predation selects against conspicuous colors in bird eggs and nests, while thermoregulatory constraints select for nest-building behavior that regulates incubation temperatures. We present results that suggest a trade-off between nest crypticity and thermoregulation of eggs based on selection of nest materials by piping plovers (Charadrius melodus), a ground-nesting bird that constructs simple, pebble-lined nests highly vulnerable to predators and exposed to temperature extremes. Piping plovers selected pebbles that were whiter and appeared closer in color to eggs than randomly available pebbles, suggesting a crypsis function. However, nests that were more contrasting in color to surrounding substrates were at greater risk of predation, suggesting an alternate strategy driving selection of white rocks. Near-infrared reflectance of nest pebbles was higher than randomly available pebbles, indicating a direct physical mechanism for heat control through pebble selection. Artificial nests constructed of randomly available pebbles heated more quickly and conferred heat to model eggs, causing eggs to heat more rapidly than in nests constructed from piping plover nest pebbles. Thermal models and field data indicated that temperatures inside nests may remain up to 2-6A degrees C cooler than surrounding substrates. Thermal models indicated that nests heat especially rapidly if not incubated, suggesting that nest construction behavior may serve to keep eggs cooler during the unattended laying period. Thus, pebble selection suggests a potential trade-off between maximizing heat reflectance to improve egg microclimate and minimizing conspicuous contrast of nests with the surrounding substrate to conceal eggs from predators. Nest construction behavior that employs light-colored, thermally reflective materials may represent an evolutionary response by birds and other egg-laying organisms to egg predation and heat stress.
C1 [Mayer, Paul M.; Ford, Robert G.; McCutchen, Marshall D.] US EPA, Off Res & Dev, Ada, OK 74820 USA.
[Smith, Levica M.; Watterson, Dustin C.] E Cent Univ, McNair Scholars Program, Ada, OK 74820 USA.
[Ryan, Mark R.] Univ Missouri, Sch Nat Resources, Columbia, MO 65211 USA.
RP Mayer, PM (reprint author), US EPA, Off Res & Dev, 919 Kerr Res Dr, Ada, OK 74820 USA.
EM mayer.paul@epa.gov
OI Mayer, Paul/0000-0002-8550-1386
FU US Environmental Protection Agency (Agency)
FX We are grateful for constructive remarks by K. Forshay, C. Lehman, A.
Person, R. Phillips, B. Root, G. Schnell, D. Siems, A. Strong, B.
Woodworth, and two astute anonymous reviewers. We thank B. Root for
assistance in the Weld. A. Person and J. Dean provided piping plover
eggs from the Sam Noble Oklahoma Museum of Natural History and the
Smithsonian Institution/National Museum of Natural History,
respectively. The US Environmental Protection Agency (Agency) through
its Office of Research and Development partially funded and collaborated
in the research described here under cooperative agreement (CR832885)
with East Central University. The research described here has not been
subjected to Agency review and therefore does not necessarily reflect
the views of the Agency, and no official endorsement should be inferred.
Mention of trade names or commercial products does not constitute
endorsement or recommendation for use. This research adhered to the
Association for the Study of Animal Behavior/Animal Behavior Society
Guidelines for the Use of Animals in Research, the legal requirements of
the country in which the work was carried out, and all institutional
guidelines.
NR 82
TC 24
Z9 26
U1 6
U2 49
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0029-8549
EI 1432-1939
J9 OECOLOGIA
JI Oecologia
PD APR
PY 2009
VL 159
IS 4
BP 893
EP 901
DI 10.1007/s00442-008-1266-9
PG 9
WC Ecology
SC Environmental Sciences & Ecology
GA 417UK
UT WOS:000264103800020
PM 19145449
ER
PT J
AU Lee, CH
Teng, Q
Huang, WL
Zhong, RQ
Ye, ZH
AF Lee, Chanhui
Teng, Quincy
Huang, Wenlin
Zhong, Ruiqin
Ye, Zheng-Hua
TI The F8H Glycosyltransferase is a Functional Paralog of FRA8 Involved in
Glucuronoxylan Biosynthesis in Arabidopsis
SO PLANT AND CELL PHYSIOLOGY
LA English
DT Article
DE Arabidopsis; Glucuronoxylan biosynthesis; Glycosyltransferase; Secondary
wall biosynthesis; Xylan
ID SECONDARY CELL-WALL; REDUCING END-GROUPS; ARABINOXYLAN BIOSYNTHESIS;
CELLULOSE SYNTHESIS; XYLAN; XYLOSYLTRANSFERASE; DIFFERENTIATION;
IDENTIFICATION; DEFICIENT; POPLAR
AB The FRAGILE FIBER8 (FRA8) gene was previously shown to be required for the biosynthesis of the reducing end tetrasaccharide sequence of glucuronoxylan (GX) in Arabidopsis thaliana. Here, we demonstrate that F8H, a close homolog of FRA8, is a functional paralog of FRA8 involved in GX biosynthesis. The F8H gene is preferentially expressed in xylem cells, in which the secondary walls contain an abundant amount of GX, and the F8H protein is targeted to the Golgi where GX is synthesized. Overexpression of F8H in the fra8 mutant completely complemented the fra8 mutant phenotypes including the secondary wall thickness of fibers and vessels, vessel morphology, GX content and the abundance of the reducing end tetrasaccharide sequence of GX, indicating that F8H shares the same biochemical function as FRA8. Although the f8h mutant alone did not show any detectable cell wall defects, the f8hfra8 double mutant exhibits an additional reduction in cell wall xylose level, a more severe deformation of vessels and an extreme retardation in plant growth compared with the fra8 mutant. Together, our findings suggest that F8H and FRA8 are functional paralogs and that they function redundantly in GX biosynthesis during secondary wall formation in the xylem.
C1 [Lee, Chanhui; Zhong, Ruiqin; Ye, Zheng-Hua] Univ Georgia, Dept Plant Biol, Athens, GA 30602 USA.
[Teng, Quincy; Huang, Wenlin] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
RP Ye, ZH (reprint author), Univ Georgia, Dept Plant Biol, Athens, GA 30602 USA.
EM zhye@plantbio.uga.edu
FU The Chemical Sciences, Geosciences and Biosciences Division, Office of
Basic Energy Sciences, Office of Science, US Department of Energy
[DE-FGO2-O3ER1 5415]
FX The Chemical Sciences, Geosciences and Biosciences Division, Office of
Basic Energy Sciences, Office of Science, US Department of Energy
(Contract No. DE-FGO2-O3ER1 5415).
NR 37
TC 48
Z9 51
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0032-0781
J9 PLANT CELL PHYSIOL
JI Plant Cell Physiol.
PD APR
PY 2009
VL 50
IS 4
BP 812
EP 827
DI 10.1093/pcp/pcp025
PG 16
WC Plant Sciences; Cell Biology
SC Plant Sciences; Cell Biology
GA 434LT
UT WOS:000265276900012
PM 19224953
ER
PT J
AU Delclos, KB
Weis, CC
Bucci, TJ
Olson, G
Mellick, P
Sadovova, N
Latendresse, JR
Thorn, B
Newbold, RR
AF Delclos, K. Barry
Weis, Constance C.
Bucci, Thomas J.
Olson, Greg
Mellick, Paul
Sadovova, Natalya
Latendresse, John R.
Thorn, Brett
Newbold, Retha R.
TI Overlapping but distinct effects of genistein and ethinyl estradiol
(EE2) in female Sprague-Dawley rats in multigenerational reproductive
and chronic toxicity studies
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Review
DE Genistein; Ethinyl estradiol; Rat; Multigenerational; Reproductive
toxicity; Estrous cycle; Puberty acceleration; Reproductive senescence;
Soy-free diet
ID ESTROGEN-RECEPTOR-BETA; SUPPRESSES MAMMARY-CANCER; PHYTOESTROGEN
GENISTEIN; NEONATAL EXPOSURE; SOY ISOFLAVONE; BREAST-CANCER;
GENE-EXPRESSION; IN-UTERO; DIETARY GENISTEIN; PRENATAL EXPOSURE
AB Genistein and ethinyl estradiol (EE2) were examined in multigenerational reproductive and chronic toxicity studies that had different treatment intervals among generations. Sprague-Dawley rats received genistein (0, 5, 100, or 500 ppm) or EE2 (0, 2, 10, or 50 ppb) in a low phytoestrogen diet. Nonneoplastic effects in females are summarized here. Genistein at 500 ppm and EE2 at 50 ppb produced similar effects in continuously exposed rats, including decreased body weights, accelerated vaginal opening, and altered estrous cycles in young animals. At the high dose, anogenital distance was subtly affected by both compounds, and a reduction in litter size was evident in genistein-treated animals. Genistein at 500 ppm induced an early onset of aberrant cycles relative to controls in the chronic studies. EE2 significantly increased the incidence of uterine lesions (atypical focal hyperplasia and squamous metaplasia). These compound-specific effects appeared to be enhanced in the offspring of prior exposed generations. Published by Elsevier Inc.
C1 [Delclos, K. Barry] Natl Ctr Toxicol Res, Div Biochem Toxicol, Jefferson, AR 72079 USA.
[Bucci, Thomas J.; Olson, Greg; Mellick, Paul; Sadovova, Natalya; Latendresse, John R.] Toxicol Pathol Associates, Jefferson, AR 72079 USA.
[Newbold, Retha R.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA.
RP Delclos, KB (reprint author), Natl Ctr Toxicol Res, Div Biochem Toxicol, HFT 110,3900 NCTR Rd, Jefferson, AR 72079 USA.
EM barry.delclos@fda.hhs.gov
FU U.S. Food and Drug Administration [IAG 224-07-007]; National Institute
for Environmental Health Sciences
FX This work was supported by Interagency Agreement IAG 224-07-007 between
the U.S. Food and Drug Administration and the National Institute for
Environmental Health Sciences. The extensive and expert technical
assistance of the NCTR support staff in providing diet preparation,
chemical analysis, animal care, computer support, necropsy, and tissue
processing services for these studies is gratefully acknowledged. The
views presented in this article do not necessarily reflect those of the
U.S. Food and Drug Administration.
NR 133
TC 36
Z9 39
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD APR
PY 2009
VL 27
IS 2
BP 117
EP 132
DI 10.1016/j.reprotox.2008.12.005
PG 16
WC Reproductive Biology; Toxicology
SC Reproductive Biology; Toxicology
GA 429BA
UT WOS:000264894600004
PM 19159674
ER
PT J
AU Conolly, RB
AF Conolly, Rory B.
TI Commentary on "Toxicity Testing in the 21st Century: Implications for
Human Health Risk Assessment" by Krewski et al.
SO RISK ANALYSIS
LA English
DT Editorial Material
ID GRADIENT
C1 US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
RP Conolly, RB (reprint author), US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, MD B205-01, Res Triangle Pk, NC 27711 USA.
EM Conolly.Rory@epa.gov
NR 10
TC 10
Z9 12
U1 1
U2 4
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0272-4332
J9 RISK ANAL
JI Risk Anal.
PD APR
PY 2009
VL 29
IS 4
BP 480
EP 481
DI 10.1111/j.1539-6924.2008.01165.x
PG 2
WC Public, Environmental & Occupational Health; Mathematics,
Interdisciplinary Applications; Social Sciences, Mathematical Methods
SC Public, Environmental & Occupational Health; Mathematics; Mathematical
Methods In Social Sciences
GA 421GM
UT WOS:000264347400003
PM 19076324
ER
PT J
AU Kavlock, RJ
Austin, CP
Tice, RR
AF Kavlock, Robert J.
Austin, Christopher P.
Tice, Raymond R.
TI Toxicity Testing in the 21st Century: Implications for Human Health Risk
Assessment
SO RISK ANALYSIS
LA English
DT Editorial Material
C1 [Kavlock, Robert J.] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Austin, Christopher P.] NHGRI, NIH Chem Genom Ctr, NIH, Bethesda, MD 20892 USA.
[Tice, Raymond R.] Natl Inst Environm Hlth Sci, Biomol Screening Branch, Natl Toxicol Program, Res Triangle Pk, NC USA.
RP Kavlock, RJ (reprint author), US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
EM Kavlock.Robert@epamail.epa.gov
FU Intramural NIH HHS [ZIA HG200319-06]
NR 2
TC 87
Z9 88
U1 0
U2 6
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0272-4332
J9 RISK ANAL
JI Risk Anal.
PD APR
PY 2009
VL 29
IS 4
BP 485
EP 487
DI 10.1111/j.1539-6924.2008.01168.x
PG 3
WC Public, Environmental & Occupational Health; Mathematics,
Interdisciplinary Applications; Social Sciences, Mathematical Methods
SC Public, Environmental & Occupational Health; Mathematics; Mathematical
Methods In Social Sciences
GA 421GM
UT WOS:000264347400006
PM 19076321
ER
PT J
AU Stepchenkova, EI
Kozmin, SG
Alenin, VV
Pavlov, YI
AF Stepchenkova, E. I.
Kozmin, S. G.
Alenin, V. V.
Pavlov, Yu. I.
TI Genetic control of metabolism of mutagenic purine base analogs
6-hydroxylaminopurine and 2-amino-6-hydroxylaminopurine in yeast
Saccharomyces cerevisiae
SO RUSSIAN JOURNAL OF GENETICS
LA English
DT Article
ID MOLYBDENUM COFACTOR BIOSYNTHESIS; ESCHERICHIA-COLI; PROTEIN; DNA;
6-N-HYDROXYLAMINOPURINE; MUTANTS; INOSINE; DAMAGE
AB We studied the effect of inactivation of genes, which control biosynthesis of inosine monophosphate (IMP) de novo and purine salvage and interconversion pathways, on sensitivity of yeast Saccharomyces cerevisiae to the mutagenic and toxic action of 6-hydroxylaminopurine (HAP) and 2-amino-6-hydroxylaminopurine (AHA). It was shown that the manifestation of HAP and AHA mutagenic properties depends on the action of enzyme adenine phosphoribosyltransferase encoded in yeast by APT1 gene. A blockade of any step of IMP biosynthesis, with the exception of the block mediated by inactivation of genes ADE16 and ADE17 leading to the accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), was shown to enhance yeast cell sensitivity to the HAP mutagenic effect; however, it does not affect the sensitivity to AHA. A block of conversion of IMP into adenosine monophosphate (AMP) causes hypersensitivity of yeast cells to the mutagenic action of HAP and to the toxic effect of HAP, AHA, and hypoxanthine. It is possible that this enhancement of sensitivity to HAP and AHA is due to changes in the pool of purines. We conclude that genes ADE12, ADE13, AAH1, and HAM1 controlling processes of purine salvage and interconversion in yeast, make the greatest contribution to the protection against the toxic and mutagenic action of the examined analogs. Possible mechanisms of HAP detoxication in bacteria, yeast, and humans are discussed.
C1 [Stepchenkova, E. I.; Kozmin, S. G.; Alenin, V. V.] St Petersburg State Univ, Dept Genet & Select, St Petersburg 199034, Russia.
[Stepchenkova, E. I.] St Petersburg State Univ, Vavilov Inst Gen Genet, St Petersburg Branch, St Petersburg 199034, Russia.
[Kozmin, S. G.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA.
[Pavlov, Yu. I.] 985880 Univ Nebraska, Med Ctr, Eppley Inst Res Canc, Omaha, NE 68198 USA.
RP Stepchenkova, EI (reprint author), St Petersburg State Univ, Dept Genet & Select, St Petersburg 199034, Russia.
EM stepchenkova@gmail.com
RI Kozmin, Stanislav/J-6849-2012; Stepchenkova, Elena/F-9931-2014
OI Kozmin, Stanislav/0000-0002-4128-4447; Stepchenkova,
Elena/0000-0002-5854-8701
FU BRHE; CRDF3; Ministry of Education of the Russian Federation
FX This study was supported by BRHE, presented by CRDF, and the Ministry of
Education of the Russian Federation.
NR 28
TC 2
Z9 2
U1 0
U2 7
PU MAIK NAUKA/INTERPERIODICA/SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 1022-7954
J9 RUSS J GENET+
JI Russ. J. Genet.
PD APR
PY 2009
VL 45
IS 4
BP 409
EP 414
DI 10.1134/S1022795409040048
PG 6
WC Genetics & Heredity
SC Genetics & Heredity
GA 437UG
UT WOS:000265511800004
ER
PT J
AU Jia, J
Lee, CR
Bradbury, JA
DeGraff, LM
Zeldin, DC
Alkayed, NJ
AF Jia, Jia
Lee, Craig R.
Bradbury, J. Alyce
DeGraff, Laura M.
Zeldin, Darryl C.
Alkayed, Nabil J.
TI P450 Epoxygenase Overexpression in Vascular Endothelium Alters Blood
Flow and Infarct Size after Middle Cerebral Artery Occlusion in a Sex-
and Isoform-Specific Manner
SO STROKE
LA English
DT Meeting Abstract
CT American-Association-International-Stroke Conference 2009
CY FEB 17-20, 2009
CL San Diego, CA
SP Amer Assoc Int Stroke
C1 [Jia, Jia; Alkayed, Nabil J.] Oregon Hlth & Sci Univ, Dept Anesthesiol & Peri Operat Med, Portland, OR 97201 USA.
[Lee, Craig R.; Bradbury, J. Alyce; DeGraff, Laura M.; Zeldin, Darryl C.] Natl Inst Environm Hlth Sci, Div Intramural Rsch, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0039-2499
J9 STROKE
JI Stroke
PD APR
PY 2009
VL 40
IS 4
BP E150
EP E150
PG 1
WC Clinical Neurology; Peripheral Vascular Disease
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA 426LJ
UT WOS:000264709500270
ER
PT J
AU Dugan, NR
Williams, DJ
Meyer, M
Schneider, RR
Speth, TF
Metz, DH
AF Dugan, Nicholas R.
Williams, Daniel J.
Meyer, Maria
Schneider, Ross R.
Speth, Thomas F.
Metz, Deborah H.
TI The impact of temperature on the performance of anaerobic biological
treatment of perchlorate in drinking water
SO WATER RESEARCH
LA English
DT Article
DE Perchlorate; Biological treatment; Temperature effects
ID SULFATE-REDUCING BACTERIA; DESULFOVIBRIO-DESULFURICANS; NITRATE
REDUCTION
AB A 20-month pilot-scale study was conducted to examine the impact of temperature on the performance of an anaerobic biological contactor used to treat perchlorate-contaminated water. The contactor was successfully acclimated with indigenous microorganisms. Influent temperatures varied from 1.4 to 30 degrees C. The objectives of the study were to investigate the effects of temperature on Perchlorate removal, nitrate removal, nitrite formation, dissolved oxygen consumption, sulfide production, and nutrient acetate consumption. The results confirmed that consistent biological perchlorate removal to 2 mu g/L is feasible at temperatures above 10 degrees C. Effluent concentrations of perchlorate, nitrate, and dissolved oxygen varied inversely with temperature, while sulfide varied positively with temperature. Under the conditions that prevailed during this study, 10 degrees C was a threshold temperature below which microbial activity, including perchlorate reduction, decreased dramatically. Published by Elsevier Ltd.
C1 [Dugan, Nicholas R.; Williams, Daniel J.; Speth, Thomas F.] US EPA, Cincinnati, OH 45268 USA.
[Meyer, Maria; Metz, Deborah H.] Greater Cincinnati Water Works, Cincinnati, OH 45228 USA.
[Schneider, Ross R.] Pegasus Tech Serv, Cincinnati, OH 45219 USA.
RP Dugan, NR (reprint author), US EPA, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM dugan.nicholas@epa.gov
NR 28
TC 11
Z9 17
U1 2
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD APR
PY 2009
VL 43
IS 7
BP 1867
EP 1878
DI 10.1016/j.watres.2009.01.032
PG 12
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 437SR
UT WOS:000265507700008
PM 19249808
ER
PT J
AU Choi, O
Cleuenger, TE
Deng, BL
Surampalli, RY
Ross, L
Hu, ZQ
AF Choi, Okkyoung
Cleuenger, Thomas E.
Deng, Baolin
Surampalli, Rao Y.
Ross, Louis, Jr.
Hu, Zhiqiang
TI Role of sulfide and ligand strength in controlling nanosilver toxicity
SO WATER RESEARCH
LA English
DT Article
DE Silver nanoparticles; Sulfide, Ligands, Microbial growth; Nitrification
ID TROUT ONCORHYNCHUS-MYKISS; SILVER NANOPARTICLES; RAINBOW-TROUT;
NITROSOMONAS-EUROPAEA; ESCHERICHIA-COLI; DAPHNIA-MAGNA; MODEL; WATER;
INHIBITION; METALS
AB Nanosilver has been used broadly in nanotechnology enhanced consumer products because of its strong antimicrobial properties. Silver nanoparticles (AgNPs) released from these products will likely enter wastewater collection and treatment systems. This research evaluated the role of sulfide and ligand strength in controlling nanosilver toxicity to nitrifying bacteria that are important in wastewater treatment. The nanosilver toxicity in the absence and presence of ligands (SO(4)(2-), S(2-), Cl(-), PO(4)(3-), and EDTA(-)) commonly present in wastewater was determined from the oxygen uptake rate measurements. Sulfide appeared to be the only ligand to effectively reduce nanosilver toxicity. By adding a small aliquot of sulfide that was stoichiometrically complexed with AgNPs, the nanosilver toxicity to nitrifying organisms was reduced by up to 80%. Scanning electron microscopy coupled with energy dispersive X-ray analysis indicated that AgNPs were highly reactive with sulfide to form new Ag(x)S(y) complexes or precipitates. These complexes were not oxidized after a prolonged period of aeration (18 h). This information is useful for wastewater treatment design and operation to reduce nanosilver toxicity via sulfide complexation. While the biotic ligand model was successful in predicting the toxicity of Ag(+) ions, it could not accurately predict the toxicity of AgNPs. Nevertheless, it could be one of the many tools useful in predicting and controlling nanosilver toxicity to wastewater microorganisms. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Choi, Okkyoung; Cleuenger, Thomas E.; Deng, Baolin; Hu, Zhiqiang] Univ Missouri, Dept Civil & Environm Engn, Columbia, MO 65211 USA.
[Surampalli, Rao Y.] US EPA, Reg Off 7, Kansas City, KS USA.
[Ross, Louis, Jr.] Univ Missouri, Electron Microscopy Core Facil, Columbia, MO 65211 USA.
RP Hu, ZQ (reprint author), Univ Missouri, Dept Civil & Environm Engn, E2509 Lafferre Hall, Columbia, MO 65211 USA.
EM huzh@missouri.edu
OI Deng, Baolin/0000-0001-6569-1808
NR 38
TC 156
Z9 164
U1 7
U2 125
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD APR
PY 2009
VL 43
IS 7
BP 1879
EP 1886
DI 10.1016/j.watres.2009.01.029
PG 8
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 437SR
UT WOS:000265507700009
PM 19249075
ER
PT J
AU Weissberger, EJ
Coiro, LL
Davey, EW
AF Weissberger, Eric J.
Coiro, Laura L.
Davey, Earl W.
TI Effects of hypoxia on animal burrow construction and consequent effects
on sediment redox profiles
SO JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY
LA English
DT Article
DE Benthos; Burrowing; Hypoxia; Redox; Tomography
ID MARINE BENTHIC COMMUNITIES; COMPUTER-AIDED TOMOGRAPHY; DISSOLVED-OXYGEN;
CHESAPEAKE BAY; LEPTOCHEIRUS-PLUMULOSUS; BIOGENIC STRUCTURES;
MISSISSIPPI RIVER; SEA SEDIMENTS; IN-SITU; RESPONSES
AB We conducted a laboratory experiment to investigate the effects of mild hypoxia on the burrowing behavior of three marine species (the hard clam Mercenaria mercenaria, the polychaete worm Neanthes virens, and the amphipod Leptocheirus plumulosus) and consequent effects on sediment redox profiles. Animals were introduced into defaunated sediment and allowed to burrow for four months at mildly hypoxic (2 mg l(-1)) and nornnoxic (7 mg l(-1)) dissolved oxygen (DO) levels. Sediment redox profiles were measured 10 times during the course of the experiment. At the end of the experiment, the sediment was imaged using computer-aided tomography to quantify burrow volume and location. For the three species, burrow volume remained constant over DO treatments, but amphipod and clam burrows were shallower in hypoxic treatments compared with normoxic treatments. Redox profile discontinuity (RPD) depth was shallower in hypoxic treatments compared with normoxic treatments for experiments without animals, indicating that water column oxygen concentration alone influences diffusion of oxygen into the sediment. Worms, but neither clams nor amphipods, increased the RPD depth relative to no-animal controls in both hypoxic and normoxic treatments, but the effect was greater in normoxic conditions. These results suggest that although hypoxia can reduce burrowing depth, infauna can still increase the depth to which oxygen penetrates the sediment, but not to the same degree as they would under normoxic conditions. Published by Elsevier B.V.
C1 [Weissberger, Eric J.; Coiro, Laura L.; Davey, Earl W.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Weissberger, EJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, 27 Tarzwell Dr, Narragansett, RI 02882 USA.
EM weissberger.eric@epa.gov
FU U.S. Environmental Protection Agency [AED-08-027]
FX Karin Tammi of Roger Williams University kindly provided clams for this
project. William Nelson assisted in collection of sediment. Joanne
Spears and Newport Hospital kindly allowed us to use their CT scanning
facilities. James Heltshe provided assistance with statistical analysis.
Patricia DeCastro provided assistance with figures. Warren Boothman,
Giancarlo Cicchetti, Glen Thursby, Joseph LiVolsi, Timothy Gleason,
Suzanne Ayvazian, Wayne Munns, and two anonymous reviewers provided
helpful comments on the manuscript. This is contribution no. AED-08-027
from the U.S. Environmental Protection Agency, Office of Research and
Development, National Health and Environmental Effects Laboratory,
Atlantic Ecology Division. Although the research described in this
article has been funded by the U. S. Environmental Protection Agency, it
has not been subjected to Agency-level review. Therefore, it does not
necessarily reflect the views of the Agency. Mention of trade names or
commercial products does not constitute endorsement or recommendation
for use. [ST]
NR 83
TC 16
Z9 18
U1 3
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-0981
J9 J EXP MAR BIOL ECOL
JI J. Exp. Mar. Biol. Ecol.
PD MAR 31
PY 2009
VL 371
IS 1
BP 60
EP 67
DI 10.1016/j.jembe.2009.01.005
PG 8
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 424HN
UT WOS:000264557900007
ER
PT J
AU Vonderhee, AP
Kauffman, PE
Hieber, TE
Brisbin, JA
Melnyk, LJ
Morgan, JN
AF Vonderhee, Anne P.
Kauffman, Peter E.
Hieber, Thomas E.
Brisbin, Judith A.
Melnyk, Lisa Jo
Morgan, Jeffrey N.
TI Development of an Analytical Scheme for the Determination of Pyrethroid
Pesticides in Composite Diet Samples
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Pesticides; composite diet; GC-MS; pyrethroids; cleanup
ID TANDEM MASS-SPECTROMETRY; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; PHASE
EXTRACTION CLEANUP; ELECTRON-CAPTURE; SYNTHETIC PYRETHROIDS; RESIDUES;
VEGETABLES; ORGANOCHLORINE; INSECTICIDES; COLUMN
AB Analysis of an individual's total daily food intake may be used to determine aggregate dietary ingestion of given compounds. However, the resulting composite sample represents a complex mixture, and measurement of such can often prove to be difficult. In this work, an analytical scheme was developed for the determination of 12 select pyrethroid pesticides in dietary samples. In the first phase of the study, several cleanup steps were investigated for their effectiveness in removing interferences in samples with a range of fat content (1 - 10%). Food samples were homogenized in the laboratory, and preparatory techniques were evaluated through recoveries from fortified samples. The selected final procedure consisted of a lyophilization step prior to sample extraction. A sequential 2-fold cleanup procedure of the extract included diatomaceous earth for removal of lipid components followed with a combination of deactivated alumina and C(18) for the simultaneous removal of polar and nonpolar interferences. Recoveries from fortified composite diet samples (10 mu g kg(-1)) ranged from 50.2 to 147%. In the second phase of this work, three instrumental techniques [gas chromatography-microelectron capture detection (GC-mu ECD), GC-quadrupole mass spectrometry (GC-quadrupole-MS), and GC-ion trap-MS/MS] were compared for greatest sensitivity. GC-quadrupole-MS operated in selective ion monitoring (SIM) mode proved to be most sensitive, yielding method detection limits of approximately 1 mu g kg(-1). The developed extraction/instrumental scheme was applied to samples collected in an exposure measurement field study. The samples were fortified and analyte recoveries were acceptable (75.9-125%); however, compounds coextracted from the food matrix prevented quantitation of four of the pyrethroid analytes in two of the samples considered.
C1 [Vonderhee, Anne P.; Melnyk, Lisa Jo; Morgan, Jeffrey N.] US EPA, Natl Exposure Res Lab, Microbiol & Chem Exposure Assessment Res Div, Chem Exposure Res Branch, Cincinnati, OH 45268 USA.
[Kauffman, Peter E.; Hieber, Thomas E.] US EPA, Natl Council Aging, Cincinnati, OH 45268 USA.
[Brisbin, Judith A.] US EPA, Off Ground Water & Drinking Water, Tech Support Ctr, Cincinnati, OH 45268 USA.
RP Morgan, JN (reprint author), US EPA, Natl Exposure Res Lab, Microbiol & Chem Exposure Assessment Res Div, Chem Exposure Res Branch, MS 564,26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM Morgan.jeffrey@epa.gov
FU The U.S. Environmental Protection Agency
FX Received for review October 17, 2008. Revised manuscript received
January 16, 2009. Accepted January 20, 2009. The U.S. Environmental
Protection Agency, through its Office of Research and Development,
funded and managed the research described here. It has been subjected to
Agency administrative review and approved for publication. Mention of
trade names or commercial products does not constitute endorsement or
recommendation for use.
NR 27
TC 15
Z9 16
U1 1
U2 18
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAR 25
PY 2009
VL 57
IS 6
BP 2096
EP 2104
DI 10.1021/jf8032446
PG 9
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
Technology
SC Agriculture; Chemistry; Food Science & Technology
GA 420QC
UT WOS:000264303300002
PM 19292459
ER
PT J
AU Lohmann, R
Bollinger, K
Cantwell, M
Feichter, J
Fischer-Bruns, I
Zabel, M
AF Lohmann, Rainer
Bollinger, Kevyn
Cantwell, Mark
Feichter, Johann
Fischer-Bruns, Irene
Zabel, Matthias
TI Fluxes of soot black carbon to South Atlantic sediments
SO GLOBAL BIOGEOCHEMICAL CYCLES
LA English
DT Article
ID POLYCYCLIC AROMATIC-HYDROCARBONS; CONTINENTAL-MARGIN SEDIMENTS;
DISSOLVED ORGANIC-MATTER; MARINE-SEDIMENTS; MOLECULAR EVIDENCE; SURFACE
SEDIMENTS; ELEMENTAL CARBON; OXIDATION METHOD; NEW-YORK; AEROSOL
AB Deep sea sediment samples from the South Atlantic Ocean were analyzed for soot black carbon (BC), total organic carbon (TOC), stable carbon isotope ratios (delta C-13), and polycyclic aromatic hydrocarbons (PAHs). Soot BC was present at low concentrations (0.04-0.17% dry weight), but accounted for 3-35% of TOC. Fluxes of soot BC were calculated on the basis of known sedimentation rates and ranged from 0.5 to 7.8 mu g cm(-2) a(-1), with higher fluxes near Africa compared to South America. Values of delta C-13 indicated a marine origin for the organic carbon but terrestrial sources for the soot BC. PAH ratios implied a pyrogenic origin for most samples and possibly a predominance of traffic emissions over wood burning off the African coast. A coupled ocean-atmosphere-aerosol-climate model was used to determine fluxes of BC from 1860 to 2000 to the South Atlantic. Model simulation and measurements both yielded higher soot BC fluxes off the African coast and lower fluxes off the South American coast; however, measured sedimentary soot BC fluxes exceeded simulated values by similar to 1 mu g cm(-2) a(-1) on average (within a factor of 2-4). For the sediments off the African coast, soot BC delivery from the Congo River could possibly explain the higher flux rates, but no elevated soot BC fluxes were detected in the Amazon River basin. In total, fluxes of soot BC to the South Atlantic were similar to 480-700 Gg a(-1) in deep sea sediments. Our results suggest that attempts to construct a global mass balance of BC should include estimates of the atmospheric deposition of BC.
C1 [Lohmann, Rainer; Bollinger, Kevyn] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA.
[Cantwell, Mark] US EPA, ORD, NHEERL, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Feichter, Johann; Fischer-Bruns, Irene] Max Planck Inst Meteorol, D-20146 Hamburg, Germany.
[Zabel, Matthias] Univ Bremen, MARUM Geowissensch, D-28334 Bremen, Germany.
RP Lohmann, R (reprint author), Univ Rhode Isl, Grad Sch Oceanog, 215 S Ferry Rd, Narragansett, RI 02882 USA.
EM lohmann@gso.uri.edu
RI Lohmann, Rainer/B-1511-2008; Zabel, Matthias/E-5044-2011;
OI Zabel, Matthias/0000-0003-4681-1821; Lohmann, Rainer/0000-0001-8796-3229
FU URI Council; Vetlesen and Monel foundations
FX R. Lohmann acknowledges support by the URI Council for Research for this
research project, support by the Vetlesen and Monel foundations, K.
Seiter (University of Bremen) for helpful discussion, A. Sweetman
(Lancaster University) for producing Figure 2, J. Sullivan (URI) for
additional BC analyses, and two anonymous reviewers for their
constructive comments.
NR 72
TC 24
Z9 25
U1 2
U2 26
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0886-6236
EI 1944-9224
J9 GLOBAL BIOGEOCHEM CY
JI Glob. Biogeochem. Cycle
PD MAR 24
PY 2009
VL 23
AR GB1015
DI 10.1029/2008GB003253
PG 13
WC Environmental Sciences; Geosciences, Multidisciplinary; Meteorology &
Atmospheric Sciences
SC Environmental Sciences & Ecology; Geology; Meteorology & Atmospheric
Sciences
GA 426BJ
UT WOS:000264682100002
ER
PT J
AU Shamim, AN
AF Shamim, A. Najm
TI Possible nanotechnology-based antimicrobial pesticides: New chemical and
difficulties involved in regulating, and conducting dietary risk
assessments
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Shamim, A. Najm] US EPA, Antimicrobials Div, Off Pesticides Programs, Arlington, VA 22202 USA.
EM Shamim.Najm@epa.gov
NR 0
TC 1
Z9 1
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 115-AGFD
BP 66
EP 66
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857800065
ER
PT J
AU Antoniou, MG
Shoemaker, JA
Nicolaou, PA
de la Cruz, AA
Dionysiou, DD
AF Antoniou, Maria G.
Shoemaker, Jody A.
Nicolaou, Persoulla A.
de la Cruz, Armah A.
Dionysiou, Dionysios D.
TI Treating water contaminated with cyanotoxins
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Antoniou, Maria G.; Dionysiou, Dionysios D.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
[Shoemaker, Jody A.; de la Cruz, Armah A.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
[Nicolaou, Persoulla A.] Univ Cincinnati, Dept Pharmacol & Cell Biophys, Coll Med, Cincinnati, OH 45267 USA.
EM antonim@email.uc.edu; shoemaker.jody@epa.gov; nicolapa@email.uc.edu;
delacruz.armah@epamail.epa.gov; dionysios.d.dionysiou@uc.edu
NR 0
TC 0
Z9 0
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 118-AGFD
BP 84
EP 84
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857800083
ER
PT J
AU Adams, WA
Namboodiri, VV
Impellitteri, CA
AF Adams, William A.
Namboodiri, Vasudevan V.
Impellitteri, Christopher A.
TI Trace analysis of DEET in water using an on-line preconcentration column
and liquid chromatography with UV photodiode array detection
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Adams, William A.; Impellitteri, Christopher A.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Namboodiri, Vasudevan V.] US EPA, Clean Proc Branch, Cincinnati, OH 45268 USA.
EM adams.william@epa.gov; namboodiri.vasudevan@epa.gov;
Impellitteri.Christopher@epa.gov
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 60-ANYL
BP 370
EP 370
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857800345
ER
PT J
AU Agarwal, S
Al-Abed, SR
Dionysiou, DD
AF Agarwal, Shirish
Al-Abed, Souhail R.
Dionysiou, Dionysios D.
TI Improved understanding of Pd/Mg systems through a study of critical
system parameters
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Agarwal, Shirish; Dionysiou, Dionysios D.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
[Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM agarwash@email.uc.edu; al-abed.souhail@epa.gov;
dionysios.d.dionysiou@uc.edu
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 158-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857804038
ER
PT J
AU Anderson, LA
Holman, E
AF Anderson, Lisa A.
Holman, Elizabeth
TI Methods for analyzing carbon sequestration at USEPA Superfund
remediation sites
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Anderson, Lisa A.] Albion Coll, Dept Chem, Albion, MI 49224 USA.
[Holman, Elizabeth] US EPA, Off Superfund Remediat & Techonol Innovat, Washington, DC 20460 USA.
EM laa10@albion.edu; holman.elizabeth@epa.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 537-CHED
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857802102
ER
PT J
AU Antoniou, MG
Nicolaou, PA
de la Cruz, AA
Dionysiou, DD
AF Antoniou, Maria G.
Nicolaou, Persoulla A.
de la Cruz, Armah A.
Dionysiou, Dionysios D.
TI Detoxification of water contaminated with the cyanotoxin,
microcystin-LR, by utilizing thin TiO2 photocatalytic films
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Antoniou, Maria G.; Dionysiou, Dionysios D.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
[Nicolaou, Persoulla A.] Univ Cincinnati, Dept Pharmacol & Cell Biophys, Cincinnati, OH 45267 USA.
[de la Cruz, Armah A.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
EM antonim@email.uc.edu; nicolapa@email.uc.edu;
delacruz.armah@epamail.epa.gov; dionysios.d.dionysiou@uc.edu
NR 0
TC 0
Z9 0
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 69-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857804053
ER
PT J
AU Baruwati, B
Polshettiwar, V
Varma, RS
AF Baruwati, Babita
Polshettiwar, Vivek
Varma, Rajender S.
TI Ruthenium supported on magnetic nanoparticles: An efficient and
recoverable catalyst for hydrogenation of alkynes and transfer
hydrogenation of carbonyl compounds
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Baruwati, Babita; Polshettiwar, Vivek; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM Baruwati.Babita@epa.gov; polshettiwar.vivek@epa.gov;
Varma.Rajender@epa.gov
RI POLSHETTIWAR, VIVEK/D-3159-2012
OI POLSHETTIWAR, VIVEK/0000-0003-1375-9668
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 744-INOR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857805158
ER
PT J
AU Baruwati, B
Varma, RS
AF Baruwati, Babita
Varma, Rajender S.
TI Conventional and microwave hydrothermal synthesis of monodispersed metal
oxide nanoparticles at liquid-liquid interface
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Baruwati, Babita; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM Baruwati.Babita@epa.gov; Varma.Rajender@epa.gov
NR 0
TC 0
Z9 0
U1 2
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 92-IEC
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857802754
ER
PT J
AU Choi, H
Al-Abed, SR
Agarwal, S
Graybill, E
AF Choi, Hyeok
Al-Abed, Souhail R.
Agarwal, Shirish
Graybill, Eric
TI Reactive activated carbon impregnated with Fe/Pd: PCBs dechlorination
reactivity and capacity, aging, and oxidation
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Choi, Hyeok; Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Agarwal, Shirish; Graybill, Eric] Pegasus Tech Serv Inc, Cincinnati, OH 45221 USA.
EM choi.hyeok@epa.gov; al-abed.souhail@epa.gov; agarwash@email.uc.edu;
graybill.eric@epa.gov
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 141-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857804046
ER
PT J
AU Cisneros, GA
Perera, L
Garcia-Diaz, M
Bebenek, K
Kunkel, T
Pedersen, LG
AF Cisneros, G. Andres
Perera, Lalith
Garcia-Diaz, Miguel
Bebenek, Katarzyna
Kunkel, Thomas
Pedersen, Lee G.
TI Quantum mechanical/molecular mechanical studies of the reaction
mechanism of human DNA polymerase lambda with Mg2+ and Mn2+
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Cisneros, G. Andres; Perera, Lalith; Garcia-Diaz, Miguel; Bebenek, Katarzyna; Kunkel, Thomas] Natl Inst Environm Hlth Sci, Struct Biol Lab, Res Triangle Pk, NC 27709 USA.
[Garcia-Diaz, Miguel; Bebenek, Katarzyna; Kunkel, Thomas] Natl Inst Environm Hlth Sci, Mol Genet Lab, Res Triangle Pk, NC 27709 USA.
[Pedersen, Lee G.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA.
EM cisnero1@niehs.nih.gov
RI Pedersen, Lee/E-3405-2013
OI Pedersen, Lee/0000-0003-1262-9861
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 93-COMP
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857803492
ER
PT J
AU Ciszewski, JT
Gonzalez, MA
AF Ciszewski, James T.
Gonzalez, Michael A.
TI Continuous, high-yield synthesis of dipyrromethanes using a spinning
tube-in-tube reacto
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Ciszewski, James T.] US EPA, Sustainable Technol Div, Cincinnati, OH 45268 USA.
[Gonzalez, Michael A.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM iecprogramchair@gmail.com; gonzalez.michael@epa.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 107-IEC
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857802841
ER
PT J
AU El Badawy, A
Luxton, T
Tolyamat, T
Scheckel, KG
AF El Badawy, Amro
Luxton, Todd
Tolyamat, Thabet
Scheckel, Kirk G.
TI Evaluating the impact of varying synthesis methods on surface charging
and aggregation of silver nanoparticles
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [El Badawy, Amro] Pegasus Tech Serv, Cincinnati, OH 45219 USA.
[Scheckel, Kirk G.] US EPA, Land Remediat & Pollut Control Div, Cincinnati, OH 45268 USA.
EM Luxton.Todd@epa.gov
RI Scheckel, Kirk/C-3082-2009
OI Scheckel, Kirk/0000-0001-9326-9241
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 128-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857804242
ER
PT J
AU El-Badawy, A
Luxton, T
Scheckle, K
Tolaymat, T
Suidan, M
AF El-Badawy, Amro
Luxton, Todd
Scheckle, Kirk
Tolaymat, Thabet
Suidan, Makram
TI Silver speciation and leachability from silver nanomaterial containing
consumer fabric
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [El-Badawy, Amro; Suidan, Makram] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
[Luxton, Todd; Scheckle, Kirk; Tolaymat, Thabet] US EPA, Cincinnati, OH 45268 USA.
EM Luxton.Todd@epa.gov; msuidan@boss.cee.uc.edu
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 129-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857804243
ER
PT J
AU Heithmar, EM
AF Heithmar, Eward M.
TI Characterizing metal-based nanoparticles in surface water by
single-particle ICPMS
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Heithmar, Eward M.] US EPA, Natl Exposure Res Lab, Las Vegas, NV 89119 USA.
EM heithmar.ed@epa.gov
NR 0
TC 1
Z9 1
U1 1
U2 7
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 58-COLL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857803227
ER
PT J
AU Honeyman, BD
Tinnacher, RM
Diaz, AD
Kantar, C
Harper, RMS
Gillow, J
AF Honeyman, Bruce D.
Tinnacher, Ruth M.
Diaz, Angelique D.
Kantar, Cetin
Harper, Ruth M. Sofield
Gillow, Jeff
TI Biogeochemistry of plutonium transport
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Honeyman, Bruce D.] Colorado Sch Mines, Golden, CO 80401 USA.
[Tinnacher, Ruth M.] Lawrence Livermore Natl Lab, Livermore, CA 94551 USA.
[Diaz, Angelique D.] US EPA, Indoor Air Tox & Transportat Program, Denver, CO 80202 USA.
[Kantar, Cetin] Mersin Univ, Dept Environm Engn, TR-33343 Mersin, Turkey.
[Harper, Ruth M. Sofield] Western Washington Univ, Bellingham, WA 98225 USA.
[Gillow, Jeff] ARCADIS US Inc, Highlands Ranch, CO 80129 USA.
EM honeyman@mines.edu
RI Tinnacher, Ruth/I-4845-2015
NR 0
TC 0
Z9 0
U1 2
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 147-GEOC
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857804360
ER
PT J
AU Joo, SH
Luxton, T
Al-Abed, SR
AF Joo, Sung Hee
Luxton, Todd
Al-Abed, Souhail R.
TI Effect of functional groups in dispersants for the transport of titanium
dioxide nanoparticles in quartz sands
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Joo, Sung Hee] Pegasus Tech Serv Inc, Cincinnati, OH 45219 USA.
[Luxton, Todd; Al-Abed, Souhail R.] US EPA, Cincinnati, OH 45268 USA.
EM Joo.Sunghee@epa.gov; Luxton.Todd@epa.gov; Abed.Souhail@epa.gov
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 164-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857804059
ER
PT J
AU Kanel, SR
Costanza, J
Pennell, KD
AF Kanel, S. R.
Costanza, Jed
Pennell, Kurt D.
TI Catalytic reduction of tetrachloroethene dense nonaqueous phase liquid
by different types of reactive iron nanoparticles
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Pennell, Kurt D.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA.
[Costanza, Jed] US EPA, Washington, DC 20004 USA.
EM sushil.kanel@ce.gatech.edu; kurt.pennell@ce.gatech.edu
RI Pennell, Kurt/F-6862-2010
OI Pennell, Kurt/0000-0002-5788-6397
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 77-COLL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857803437
ER
PT J
AU Karn, B
AF Karn, Barbara
TI Progress in green nanotechnology and this symposium
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Karn, Barbara] US EPA, Natl Ctr Environm Res, Washington, DC 20460 USA.
EM karn.barbara@epa.gov
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 9-IEC
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857802783
ER
PT J
AU Kikandi, SN
Wang, Q
Sadik, OA
Varner, KE
AF Kikandi, Samuel. N.
Wang, Qiong
Sadik, Omowunmi. A.
Varner, Katrina. E.
TI Novel sensors for quantitation and cytotoxicity of selected
nanomaterials
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Kikandi, Samuel. N.; Wang, Qiong; Sadik, Omowunmi. A.] SUNY Binghamton, Dept Chem, Binghamton, NY 13902 USA.
[Varner, Katrina. E.] US EPA, Characterizat Res Div, NERL, Las Vegas, NV 89193 USA.
EM skikand1@binghamton.edu; qwang3@binghamton.edu; osadik@binghamton.edu;
varner.katrina@epamail.epa.gov
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 240-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857804198
ER
PT J
AU Kong, LJ
Chen, K
Zepp, R
AF Kong, Lingjun
Chen, Kyle
Zepp, Richard
TI Investigation of photochemical properties of C-60 aggregates in water
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Kong, Lingjun] US EPA, Natl Res Council Associate, NERL ERD, Athens, GA 30605 USA.
[Chen, Kyle] US EPA, Ecosyst Res Div, Athens, GA 30605 USA.
EM kong.lynn@epa.gov; zepp.richard@epa.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 204-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857804223
ER
PT J
AU Mills, M
AF Mills, Marc
TI Endocrine disrupting chemicals and other emerging contaminants in
wastewater and drinking water treatment technologies
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Mills, Marc] US EPA, ORD NRMRL, Cincinnati, OH 45268 USA.
EM mills.marc@epamail.epa.gov
NR 0
TC 0
Z9 0
U1 1
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 41-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857804228
ER
PT J
AU Pelaez, M
de la Cruz, AA
Dionysiou, DD
AF Pelaez, Miguel
de la Cruz, Armah A.
Dionysiou, Dionysios D.
TI Role of natural water matrix in the photocatalytic degradation of
microcystin-LR with NF-TiO2 films
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Pelaez, Miguel; Dionysiou, Dionysios D.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
[de la Cruz, Armah A.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
EM pelaezma@uc.edu; delacruz.armah@epamail.epa.gov;
dionysios.d.dionysiou@uc.edu
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 117-IEC
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857802791
ER
PT J
AU Polshettiwar, V
Varma, RS
AF Polshettiwar, Vivek
Varma, Rajender S.
TI ORGN 271-Functionalized magnetic nanoparticles: A novel heterogeneous
catalyst support
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Polshettiwar, Vivek; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM polshettiwar.vivek@epa.gov; Varma.Rajender@epa.gov
RI POLSHETTIWAR, VIVEK/D-3159-2012
OI POLSHETTIWAR, VIVEK/0000-0003-1375-9668
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 271-ORGN
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857806180
ER
PT J
AU Polshettiwar, V
Varma, RS
AF Polshettiwar, Vivek
Varma, Rajender S.
TI Microwave-assisted synthesis of dendritic nanoferrites and their
applications in catalysis
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Polshettiwar, Vivek; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM polshettiwar.vivek@epa.gov; Varma.Rajender@epa.gov
RI POLSHETTIWAR, VIVEK/D-3159-2012
OI POLSHETTIWAR, VIVEK/0000-0003-1375-9668
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 484-INOR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857805163
ER
PT J
AU Polshettiwar, V
Varma, RS
AF Polshettiwar, Vivek
Varma, Rajender S.
TI Organo- and nano-catalyst in greener reaction medium: Microwave-assisted
expedient synthesis of fine chemicals
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Polshettiwar, Vivek; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM polshettiwar.vivek@epa.gov; Varma.Rajender@epa.gov
RI POLSHETTIWAR, VIVEK/D-3159-2012
OI POLSHETTIWAR, VIVEK/0000-0003-1375-9668
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 41-CHED
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857801176
ER
PT J
AU Savage, NF
AF Savage, Nora F.
TI US EPA: Nanotechnology green applications and other environmental
benefits
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Savage, Nora F.] US EPA, ORD, NCER, Washington, DC 20460 USA.
EM savage.nora@epa.gov
NR 0
TC 0
Z9 0
U1 1
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 10-IEC
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857802825
ER
PT J
AU Varma, RS
Nadagouda, MN
AF Varma, Rajender S.
Nadagouda, Mallikarjuna N.
TI Greener strategies for the synthesis of nanomaterials and nanocomposites
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Varma, Rajender S.; Nadagouda, Mallikarjuna N.] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM Varma.Rajender@epa.gov; mallikarjuna.nadagouda@epa.gov
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 87-IEC
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857802758
ER
PT J
AU Varma, RS
AF Varma, Rajender S.
TI Microwave-assisted synthesis of organics and nanomaterials
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Varma, Rajender S.] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA.
EM Varma.Rajender@epa.gov
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 40-CHED
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857801431
ER
PT J
AU Zhao, AQ
Sahle-Demessie, E
Sorial, GA
AF Zhao, Amy Q.
Sahle-Demessie, E.
Sorial, George A.
TI Reduction of perchlorate from contaminated waters using zero valent iron
and palladium enhanced by UV light
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
C1 [Sahle-Demessie, E.] US EPA, Sustainable Technol Div, ORD, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Sorial, George A.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
EM zhao.amy@epa.gov; sahle-demessie.endalkachew@epamail.epa.gov;
George.Sorial@uc.edu
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 22
PY 2009
VL 237
MA 97-ENVR
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA V16GJ
UT WOS:000207857804003
ER
PT J
AU Baruwati, B
Polshettiwar, V
Varma, RS
AF Baruwati, Babita
Polshettiwar, Vivek
Varma, Rajender S.
TI Magnetically recoverable supported ruthenium catalyst for hydrogenation
of alkynes and transfer hydrogenation of carbonyl compounds
SO TETRAHEDRON LETTERS
LA English
DT Article
DE Ruthenium catalyst; Magnetically separable; Hydrogenation; Microwave
heating; Transfer hydrogenation
ID ASYMMETRIC TRANSFER HYDROGENATION; FERRITE NANOPARTICLES; BULK
SYNTHESIS; IONIC LIQUIDS; PD; TRANSFORMATIONS; COMPLEXES; GREENER; RU;
AG
AB A ruthenium (Ru) Catalyst Supported on magnetic nanoparticles (NiFe(2)O(4)) has been successfully synthesized and used for hydrogenation of alkynes at room temperature as well as transfer hydrogenation of a number of carbonyl compounds under microwave it-radiation conditions. The catalyst shows excellent selectivity towards the desired products with very high yield even after 5 repeated uses. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Baruwati, Babita; Polshettiwar, Vivek; Varma, Rajender S.] US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, Cincinnati, OH 45268 USA.
RP Varma, RS (reprint author), US EPA, Natl Risk Management Res Lab, Sustainable Technol Div, MS 443,26 W MLK Dr, Cincinnati, OH 45268 USA.
EM Varma.Rajender@epa.gov
RI POLSHETTIWAR, VIVEK/D-3159-2012
OI POLSHETTIWAR, VIVEK/0000-0003-1375-9668
NR 31
TC 60
Z9 61
U1 1
U2 24
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0040-4039
J9 TETRAHEDRON LETT
JI Tetrahedron Lett.
PD MAR 18
PY 2009
VL 50
IS 11
BP 1215
EP 1218
DI 10.1016/j.tetlet.2009.01.014
PG 4
WC Chemistry, Organic
SC Chemistry
GA 412UL
UT WOS:000263749600015
ER
PT J
AU Birnbaum, LS
AF Birnbaum, Linda S.
TI CLARIFYING BPA INFORMATION (vol 87, pg 7, 2009)
SO CHEMICAL & ENGINEERING NEWS
LA English
DT Correction
C1 Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
RP Birnbaum, LS (reprint author), Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0009-2347
J9 CHEM ENG NEWS
JI Chem. Eng. News
PD MAR 16
PY 2009
VL 87
IS 11
BP 2
EP 2
PG 1
WC Chemistry, Multidisciplinary; Engineering, Chemical
SC Chemistry; Engineering
GA 424UF
UT WOS:000264593100003
ER
PT J
AU Kaplan, PO
Decarolis, J
Thorneloe, S
AF Kaplan, P. Ozge
Decarolis, Joseph
Thorneloe, Susan
TI Is It Better To Burn or Bury Waste for Clean Electricity Generation?
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID MUNICIPAL SOLID-WASTE; DECISION-SUPPORT TOOL; LABORATORY-SCALE
LANDFILLS; LIFE-CYCLE ASSESSMENT; ENERGY PROJECTS; MANAGEMENT;
COMBUSTION; COMPONENTS; INVENTORY; MODEL
AB The use of municipal solid Waste (MSW) to generate electricity through landfill-gas-to-energy (LFGTE) and waste-to-energy (WTE) projects represents roughly 14% of U.S. nonhydro renewable electricity generation. Although various aspects of LFGTE and WTE have been analyzed in the literature, this paper is the first to present a comprehensive set of life-cycle emission factors per unit of electricity generated for these energy recovery options. In addition, sensitivity analysis is conducted on key inputs (e.g., efficiency of the WTE plant, landfill gas management schedules, oxidation rate, and waste composition) to quantify the variability in the resultant life-cycle emissions estimates. While methane from landfills results from the anaerobic breakdown of biogenic materials, the energy derived from WTE results from the combustion of both biogenic and fossil materials. The greenhouse gas emissions for WTE ranges from 0.4 to 1.5 MTCO(2)e/MWh, whereas the most agressive LFGTE scenerio results in 2.3 MTCO(2)e/MWh. WTE also produces lower NO, emissions than LFGTE, whereas SO, emissions depend on the specific configurations of WTE and LFGTE.
C1 [Decarolis, Joseph] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Thorneloe, Susan] N Carolina State Univ, Dept Civil Engn, Raleigh, NC 27695 USA.
RP Kaplan, PO (reprint author), US EPA, Oak Ridge Inst Res & Educ Postdoctoral Fellowship, Oak Ridge, TN USA.
EM kaplan.ozge@epa.gov
RI DeCarolis, Joseph/F-4869-2013;
OI DeCarolis, Joseph/0000-0003-4677-4522
NR 28
TC 34
Z9 34
U1 1
U2 36
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAR 15
PY 2009
VL 43
IS 6
BP 1711
EP 1717
DI 10.1021/es802395e
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 417WI
UT WOS:000264108800012
PM 19368161
ER
PT J
AU Ludwig, RD
Smyth, DJA
Blowes, DW
Spink, LE
Wilkin, RT
Jewett, DG
Weisener, CJ
AF Ludwig, Ralph D.
Smyth, David J. A.
Blowes, David W.
Spink, Laura E.
Wilkin, Richard T.
Jewett, David G.
Weisener, Christopher J.
TI Treatment of Arsenic, Heavy Metals, and Acidity Using a Mixed
ZVI-Compost PRB
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ZERO-VALENT IRON; PERMEABLE REACTIVE BARRIERS; SULFATE-REDUCING
BACTERIA; MINE DRAINAGE; ZEROVALENT IRON; REMOVAL; WATER; PRECIPITATION;
AQUIFERS; FIELD
AB A 30-month performance evaluation of a pilot permeable reactive barrier (PRB) consisting of a mixture of leaf compost zero-valent iron (ZVI), limestone, and pea gravel was conducted at a former phosphate fertilizer manufacturing facility in Charleston, SC. The PRB is designed to remove heavy metals and arsenic from groundwater by promoting microbially mediated sulfate reduction and sulfide-mineral precipitation and arsenic and heavy metal sorption. Performance monitoring showed effective treatment of As, Pb, Cd, Zn, and Ni from concentrations. as high as 206 mg L(-1), 2.02 mg L(-1), 0.324 mg L(-1), 1060 mg L(-1), and 2.12 mg L(-1), respectively, entering the PRB, to average concentrations of <0.03 mg L(-1), < 0.003 mg L(-1), < 0.001 mg L(-1), < 0.23 mg L(-1), and <0.003 mg L(-1), respectively, within the PRB. Both As(III)) and As(V) were effectively removed from solution with X-ray absorption near edge structure (XANES) analysis of core samples indicating the presence of As(V) in oxygen-bound form and As(III) in both oxygen- and sulfur-bound forms. XANES solid phase sulfur analysis indicated decreases in the peak amplitude of intermediate oxidized sulfur species and sulfate components with increasing distance and depth within the PRB.
C1 [Ludwig, Ralph D.; Wilkin, Richard T.; Jewett, David G.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ada, OK 74820 USA.
[Smyth, David J. A.; Blowes, David W.; Spink, Laura E.] Univ Waterloo, Waterloo, ON N2L 3G1, Canada.
[Weisener, Christopher J.] Univ Windsor, Windsor, ON N9B 3P4, Canada.
RP Ludwig, RD (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ada, OK 74820 USA.
EM ludwig.ralph@epa.gov
RI ID, MRCAT/G-7586-2011
NR 31
TC 36
Z9 45
U1 5
U2 77
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAR 15
PY 2009
VL 43
IS 6
BP 1970
EP 1976
DI 10.1021/es802394p
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 417WI
UT WOS:000264108800051
PM 19368200
ER
PT J
AU Conny, JM
Norris, GA
Gould, TR
AF Conny, J. M.
Norris, G. A.
Gould, T. R.
TI Factorial-based response-surface modeling with confidence intervals for
optimizing thermal-optical transmission analysis of atmospheric black
carbon
SO ANALYTICA CHIMICA ACTA
LA English
DT Article
DE Atmospheric aerosol; Light-absorbing carbon; Elemental carbon;
Thermal-optical analysis; Response-surface modeling
ID LIGHT-ABSORPTION MEASUREMENTS; ELEMENTAL CARBON; AEROSOL-PARTICLES;
INTEGRATING PLATE; ORGANIC-CARBON; UNITED-STATES; FILTER; REFLECTANCE;
TRANSMITTANCE; AETHALOMETER
AB Thermal-optical transmission (TOT) analysis measures black carbon (BC) in atmospheric aerosol on a fibrous filter. The method pyrolyzes organic carbon (OC) and employs laser light absorption to distinguish BC from the pyrolyzed OC: however, the instrument does not necessarily separate the two physically. In addition, a comprehensive temperature protocol for the analysis based on the Beer-Lambert Law remains elusive. Here, empirical response-surface modeling was used to show how the temperature protocol in TOT analysis can be modified to distinguish pyrolyzed OC from BC based on the Beer-Lambert Law. We determined the apparent specific absorption cross sections for pyrolyzed OC (sigma(Char)) and BC (sigma(BC)), which accounted for individual absorption enhancement effects within the filter. Response-surface models of these cross sections were derived from a three-factor central-composite factorial experimental design: temperature and duration of the high-temperature step in the helium phase, and the heating increase in the helium-oxygen phase. The response surface for sigma(BC), which varied with instrument conditions. revealed a ridge indicating the correct conditions for OC pyrolysis in helium. The intersection of the sigma(BC) and sigma(Char) surfaces indicated the conditions where the cross sections were equivalent, satisfying an important assumption upon which the method relies. 95% confidence interval surfaces defined a confidence region for a range of pyrolysis conditions. Analyses of wintertime samples from Seattle, WA revealed a temperature between 830 degrees C and 850 degrees C as most suitable for the helium high-temperature step lasting 150s. However, a temperature as low as 750 degrees C could not be rejected statistically. Published by Elsevier B.V.
C1 [Conny, J. M.] NIST, Surface & Microanal Sci Div, Gaithersburg, MD 20899 USA.
[Norris, G. A.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Gould, T. R.] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA.
RP Conny, JM (reprint author), NIST, Surface & Microanal Sci Div, 100 Bur Dr Stop 8372, Gaithersburg, MD 20899 USA.
EM joseph.conny@nist.gov
FU United States Environmental Protection Agency [DW-13-93997301-01]
FX The authors would like to thank D. Napier, J. Brown, and E. Edgerton of
Atmospheric Research and Analysis, Durham, NC, and S. Biswas, B.
Chakrabarti, and C. Sioutas of the Dept. of Civil and Environmental
Engineering, Univ. of Southern California, Los Angeles, CA for
assistance in collecting samples. In addition, we thank J.J. Filliben of
NIST for helpful discussions on the experimental design used in this
study. This work was funded by the United States Environmental
Protection Agency under interagency agreement (IAG) contract
#DW-13-93997301-01 with NIST. Mention of trade names or commercial
products does not constitute endorsement or recommendation for use by
the U.S.EPA.
NR 48
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0003-2670
J9 ANAL CHIM ACTA
JI Anal. Chim. Acta
PD MAR 9
PY 2009
VL 635
IS 2
BP 144
EP 156
DI 10.1016/j.aca.2008.12.046
PG 13
WC Chemistry, Analytical
SC Chemistry
GA 413AE
UT WOS:000263764500003
PM 19216871
ER
PT J
AU Lu, XX
Wilson, JT
Kampbell, DH
AF Lu, Xiaoxia
Wilson, John T.
Kampbell, Donald H.
TI Comparison of an assay for Dehalococcoides DNA and a microcosm study in
predicting reductive dechlorination of chlorinated ethenes in the field
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Chlorinated ethenes; Reductive dechlorination; Detection of
Dehalococcoides DNA; Microcosm study; Ground water
ID VINYL-CHLORIDE REDUCTASE; IN-GROUND WATER; SP STRAIN; IDENTIFICATION;
BACTERIUM; HYDROGEN; RATES
AB The study aims to compare the detection of 16S rRNA gene of Dehalococcoides species and the microcosm study for biotransformation in predicting reductive dechlorination of chlorinated ethenes in ground water at hazardous waste sites. A total of 72 ground water samples were collected from 12 PCE or TCE contaminated sites in the United States. The samples were analyzed and used to construct microcosms in the laboratory. The results showed that the presence of Dehalococcoides DNA was well associated with dechlorination to ethene in the field. Nearly half of the wells where Dehalococcoides DNA was detected had ethene as a dechlorination end product. In comparison, for ground water samples of 16 wells where ethene was detected, ethene was produced in 11 of the corresponding microcosms. For most microcosms, during two years of incubation, dechlorination was less extensive than that observed in the field. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Lu, Xiaoxia] Peking Univ, Coll Urban & Environm Sci, Beijing 100871, Peoples R China.
[Wilson, John T.; Kampbell, Donald H.] US EPA, Off Res & Dev, Kerr Ctr, Ada, OK 74820 USA.
RP Lu, XX (reprint author), Peking Univ, Coll Urban & Environm Sci, Yiheyuan Rd 5, Beijing 100871, Peoples R China.
EM luxx@urban.pku.edu.cn
FU National Research Council Research Associateship Award; U.S.
Environmental Protection Agency through its Office of Research and
Development [3674]
FX This work was performed while the first author (Xiaoxia Lu) held a
National Research Council Research Associateship Award at the U.S.
Environmental Protection Agency. The U.S. Environmental Protection
Agency through its Office of Research and Development partially funded
the research described here under an in-house project (Task 3674, MNA of
Chlorinated Solvents). Portions of this work were supported through IAG
# RW-57939566 "Identification of Processes that Control Natural
Attenuation at Chlorinated Solvent Spill Sites" and IAG # RW57939929
"Identification of Mineral Substances that Enhance Natural
Non-Biological Attenuation of Chlorinated Organic Contaminants in Ground
Water" between U.S. EPA and the U.S. Air Force Center for Environmental
Excellence. The authors thank Cherri Adair and Phil Kaiser (U.S. EPA)
for their assistance with field sampling and thank Phil Dennis and
Ximena Druar (SiREM) for their assistance on Dehalococcoides DNA test.
In addition, the authors are grateful to the help from the site managers
who provided site maps and/or reports.
NR 27
TC 9
Z9 10
U1 2
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD MAR 3
PY 2009
VL 157
IS 3
BP 809
EP 815
DI 10.1016/j.envpol.2008.11.015
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 408SB
UT WOS:000263454100014
PM 19121882
ER
PT J
AU Nacci, D
Huber, M
Champlin, D
Jayaraman, S
Cohen, S
Gauger, E
Fong, A
Gomez-Chiarri, M
AF Nacci, Diane
Huber, Marina
Champlin, Denise
Jayaraman, Saro
Cohen, Sarah
Gauger, Eric
Fong, Allison
Gomez-Chiarri, Marta
TI Evolution of tolerance to PCBs and susceptibility to a bacterial
pathogen (Vibrio harveyi) in Atlantic killifish (Fundulus heteroclitus)
from New Bedford (MA, USA) harbor
SO ENVIRONMENTAL POLLUTION
LA English
DT Review
DE PCB tolerance; Genetic adaptation; Fitness costs; Infectious disease
ID JUVENILE CHINOOK SALMON; POLYCHLORINATED-BIPHENYLS PCBS; ESTUARINE FISH;
IMMUNE-RESPONSES; INNATE IMMUNITY; ENVIRONMENTAL CONTAMINANTS;
INSECTICIDE RESISTANCE; AROMATIC-HYDROCARBONS; PARALICHTHYS-DENTATUS;
ICTALURUS-PUNCTATUS
AB A population of the non-migratory estuarine fish Fundulus heteroclitus (Atlantic killifish) resident to New Bedford (NB), Massachusetts, USA, an urban harbor highly contaminated with polychlorinated biphenyls (PCBs), demonstrates recently evolved tolerance to some aspects of PCB toxicity. PCB toxicology, ecological theory, and some precedence supported expectations of increased susceptibility to pathogens in NB killifish. However, laboratory bacterial challenges of the marine pathogen Vibrio harveyi to wild fish throughout the reproductive season and to their mature laboratory-raised progeny demonstrated comparable survival by NB and reference killifish, and improved survival by NB males. These results are inconsistent with hypothesized trade-offs of adaptation, and suggest that evolved tolerance in NB killifish may include mechanisms that minimize the immunosuppressive effects of PCBs. Compensatory strategies of populations persisting in highly contaminated environments provide a unique perspective for understanding the long-term ecological effects of toxic chemicals. Published by Elsevier Ltd.
C1 [Nacci, Diane; Huber, Marina; Champlin, Denise; Jayaraman, Saro] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI USA.
[Cohen, Sarah] San Francisco State Univ, Dept Biol, Romberg Tiburon Ctr, San Francisco, CA 94132 USA.
[Gauger, Eric; Fong, Allison; Gomez-Chiarri, Marta] Univ Rhode Isl, Dept Fisheries Aquaculture & Vet Sci, Kingston, RI 02881 USA.
RP Nacci, D (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI USA.
EM nacci.diane@epa.gov; akualtzin@yahoo.com; champlin.denise@epa.gov;
jayaraman.saro@epa.gov; sarahcoh@sfsu.edu; ejgauger@yahoo.com;
fonga@hawaii.edu; gomezchi@uri.edu
FU S EPA ORD NHEERL Atlantic Ecology Division [AED-05-079]; Rhode Island
Agricultural Experiment Station; University of Rhode Island Coastal
Fellowship; NCRR, NIH [P20 RR16457]
FX We appreciate the technical assistance of Jane Copeland, and James
Heltshe, and the helpful advice from reviewers of early drafts, Glen
Thursby, Jason Grear, and Anne Kuhn, as well as that of anonymous
reviewers contributing to the final version of this manuscript. This is
contribution number AED-05-079 of the US EPA ORD NHEERL Atlantic Ecology
Division. Although the research described in this contribution has been
funded partially by the US EPA, it has not been subjected to
Agency-level review. Therefore, it does not necessarily reflect the
views of the agency. Mention of trade names, products, or services does
not constitute endorsement or recommendation for use. E. Gauger received
support from the Rhode Island Agricultural Experiment Station. Funding
for A. Fong was provided by the University of Rhode Island Coastal
Fellowship program. Some aspects of this research were also made
possible by the use of the Rhode Island-INBRE Research Core facility,
supported by Grant #P20 RR16457 from NCRR, NIH.
NR 108
TC 9
Z9 9
U1 4
U2 27
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD MAR 3
PY 2009
VL 157
IS 3
BP 857
EP 864
DI 10.1016/j.envpol.2008.11.016
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 408SB
UT WOS:000263454100020
PM 19110353
ER
PT J
AU Liao, YY
Plummer, NW
George, MD
Abramowitz, J
Zhu, MX
Birnbaumer, L
AF Liao, Yanhong
Plummer, Nicholas W.
George, Margaret D.
Abramowitz, Joel
Zhu, Michael Xi
Birnbaumer, Lutz
TI A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai
complex may mediate store and receptor operated Ca2+ entry
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE diacylglycerol; STIM1; store operated calcium entry; transient receptor
potential
ID INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; PLASMA MEMBRANE JUNCTIONS;
TRANSIENT RECEPTOR; CHANNEL FUNCTION; CALCIUM CURRENT; CATION CHANNEL;
STIM1; ACTIVATION; CRAC; DEPLETION
AB TRPC and Orai proteins have both been proposed to form Ca2+ selective, store-operated calcium entry (SOCE) channels that are activated by store-depletion with Ca2+ chelators or calcium pump inhibitors. In contrast, only TRPC proteins have been proposed to form nonselective receptor-operated calcium entry (ROCE) cation channels that are activated by Gq/Gi-PLC beta signaling, which is the physiological stimulus for store depletion. We reported previously that a dominant negative Orai1 mutant, R91W, inhibits Ca2+ entry through both SOCE and ROCE channels, implicating Orai participation in both channel complexes. However, the argument for Orai participating in ROCE independently of store depletion is tenuous because store depletion is an integral component of the ROCE response, which includes formation of IP3, a store-depleting agent. Here we show that the R91W mutant also blocks diacylglycerol (DAG)-activated Ca2+ entry into cells that stably, or transiently, express DAG-responsive TRPC proteins. This strongly suggests that Orai and TRPC proteins form complexes that participate in Ca2+ entry with or without activation of store depletion. To integrate these results with recent data linking SOCE with recruitment of Orai and TRPCs to lipid rafts by STIM, we develop the hypothesis that Orai: TRPC complexes recruited to lipid rafts mediate SOCE, whereas the same complexes mediate ROCE when they are outside of lipid rafts. It remains to be determined whether the molecules forming the permeation pathway are the same when Orai: TRPC complexes mediate ROCE or SOCE.
C1 [Liao, Yanhong; Plummer, Nicholas W.; George, Margaret D.; Abramowitz, Joel; Birnbaumer, Lutz] Natl Inst Environm Hlth Sci, Neurobiol Lab, Div Intramural Res, NIH,Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA.
[Zhu, Michael Xi] Ohio State Univ, Dept Neurosci & Biochem, Columbus, OH 43210 USA.
[Zhu, Michael Xi] Ohio State Univ, Ctr Mol Neurobiol, Columbus, OH 43210 USA.
RP Birnbaumer, L (reprint author), Natl Inst Environm Hlth Sci, Neurobiol Lab, Div Intramural Res, NIH,Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA.
EM birnbau1@niehs.nih.gov
RI Abramowitz, Joel/A-2620-2015;
OI Plummer, Nicholas/0000-0003-2971-814X
FU Intramural Research Program of the NIH [Z01-ES-101684]
FX This work was supported by the Intramural Research Program of the NIH
(Z01-ES-101684).
NR 44
TC 107
Z9 111
U1 0
U2 5
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 3
PY 2009
VL 106
IS 9
BP 3202
EP 3206
DI 10.1073/pnas.0813346106
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 414DM
UT WOS:000263844100042
PM 19221033
ER
PT J
AU Polshettiwar, V
Baruwati, B
Varma, RS
AF Polshettiwar, Vivek
Baruwati, Babita
Varma, Rajender S.
TI Self-Assembly of Metal Oxides into Three-Dimensional Nanostructures:
Synthesis and Application in Catalysis
SO ACS NANO
LA English
DT Article
DE metal oxides; nanocatalyst; green organic transformations
ID SILVER DENDRITIC NANOSTRUCTURES; SHAPE-CONTROLLED SYNTHESIS; ONE-POT
SYNTHESIS; AQUEOUS-MEDIUM; ANISOTROPIC GROWTH; COUPLING REACTIONS; CDSE
NANOCRYSTALS; NANOPARTICLES; MULTIPODS; GOLD
AB Nanostructured metal (Fe, Co, Mn, Cr, Mo) oxides were fabricated under microwave irradiation conditions in pure water without using any reducing or capping reagent. The metal oxides self-assembled into octahedra, spheres, triangular rods, pine, and hexagonal snowflake-like three-dimensional morphologies. Pine-structured nano-iron oxides were studied as a novel support for various catalytic organic transformations.
C1 [Polshettiwar, Vivek; Baruwati, Babita; Varma, Rajender S.] US EPA, Sustainable Technol Div, Natl Risk Management Lab, Cincinnati, OH 45268 USA.
RP Polshettiwar, V (reprint author), US EPA, Sustainable Technol Div, Natl Risk Management Lab, 26 W MLK Dr,MS 443, Cincinnati, OH 45268 USA.
EM polshettiwar.vivek@epa.gov; varma.rajender@epa.gov
RI POLSHETTIWAR, VIVEK/D-3159-2012
OI POLSHETTIWAR, VIVEK/0000-0003-1375-9668
NR 65
TC 173
Z9 176
U1 11
U2 167
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1936-0851
J9 ACS NANO
JI ACS Nano
PD MAR
PY 2009
VL 3
IS 3
BP 728
EP 736
DI 10.1021/nn800903p
PG 9
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 423ZL
UT WOS:000264535200034
PM 19209927
ER
PT J
AU Baldauf, R
Watkins, N
Heist, D
Bailey, C
Rowley, P
Shores, R
AF Baldauf, R.
Watkins, N.
Heist, D.
Bailey, C.
Rowley, P.
Shores, R.
TI Near-road air quality monitoring: Factors affecting network design and
interpretation of data
SO AIR QUALITY ATMOSPHERE AND HEALTH
LA English
DT Review
DE Air quality; Health studies; Monitoring network design; Near-road;
Traffic emissions
AB The growing number of health studies identifying adverse health effects for populations spending significant amounts of time near large roadways has increased the interest in monitoring air quality in this microenvironment. Designing near-road air monitoring networks or interpreting previously collected near-road monitoring data is essential for transportation system planning, environmental impact assessments, and exposure assessments in health studies. For these applications, care must be taken in determining the pollutants of interest for both air quality and health assessments. In addition, planners and data analysts need to evaluate and understand the potential influence of the roadway type, design, and presence of roadside structures on the potential transport and dispersion of traffic-emitted pollutants on these air quality and health evaluations. This paper summarizes key factors related to the collection and interpretation of near-road air quality data from the perspective of the pollutants of interest and the location of the monitoring sites.
C1 [Baldauf, R.; Shores, R.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Watkins, N.] US EPA, Off Air & Radiat, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
[Heist, D.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Baldauf, R.; Bailey, C.; Rowley, P.] US EPA, Off Air & Radiat, Off Transportat & Air Qual, Natl Vehicle & Fuel Emiss Lab, Ann Arbor, MI USA.
RP Baldauf, R (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Baldauf.Richard@epa.gov
NR 25
TC 28
Z9 28
U1 1
U2 21
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1873-9318
J9 AIR QUAL ATMOS HLTH
JI Air Qual. Atmos. Health
PD MAR
PY 2009
VL 2
IS 1
BP 1
EP 9
DI 10.1007/s11869-009-0028-0
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA V25HQ
UT WOS:000208469500001
ER
PT J
AU Ryman-Rasmussen, JP
Tewksbury, EW
Moss, OR
Cesta, MF
Wong, BA
Bonner, JC
AF Ryman-Rasmussen, Jessica P.
Tewksbury, Earl W.
Moss, Owen R.
Cesta, Mark F.
Wong, Brian A.
Bonner, James C.
TI Inhaled Multiwalled Carbon Nanotubes Potentiate Airway Fibrosis in
Murine Allergic Asthma
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Article
DE carbon nanotubes; asthma; fibrosis; lung
ID INTRATRACHEAL INSTILLATION; PULMONARY TOXICITY; MICE; PARTICLES;
INTERLEUKIN-13; FIBROBLASTS; DEPOSITION; RESPONSES; EXPOSURE
AB Carbon nanotubes are gaining increasing attention due to possible health risks from occupational or environmental exposures. This study tested the hypothesis that inhaled multiwalled carbon nanotubes (MWCNT) would increase airway fibrosis in mice with allergic asthma. Normal and ovalbumin-sensitized mice were exposed to a MWCNT aerosol (100 mg/m(3)) or saline aerosol for 6 hours. Lung injury, inflammation, and fibrosis were examined by histopathology, clinical chemistry, ELISA, or RT-PCR for cytokines/chemokines, growth factors, and Collagen at 1 and 14 days after inhalation. Inhaled MWCNT were distributed throughout the lung and found in macrophages by light microscopy, but were also evident in epithelial cells by electron microscopy. Quantitative morphometry showed significant airway fibrosis at 14 days in mice that received a combination of ovalbumin and MWCNT, but not in mice that received ovalbumin or MWCNT only. Ovalbumin-sensitized mice that did not inhale MWCNT had elevated levels IL-13 and transforming growth factor (TGF)-beta 1 in lung lavage fluid, but not platelet-derived growth factor (PDGF)-AA. In contrast, unsensitized mice that inhaled MWCNT had elevated PDGF-AA, but not increased levels of TGF-beta 1 and IL-13. This suggested that airway fibrosis resulting from combined ovalbumin sensitization and MWCNT inhalation requires PDGF, a potent fibroblast mitogen, and TGF-beta 1, which stimulates Collagen production. Combined ovalbumin sensitization and MWCNT inhalation also synergistically increased IL-5 mRNA levels, which could further contribute to airway fibrosis. These data indicate that inhaled MWCNT require pre-existing inflammation to cause airway fibrosis. Our findings suggest that individuals with pre-existing allergic inflammation may be susceptible to airway fibrosis from inhaled MWCNT.
C1 [Ryman-Rasmussen, Jessica P.; Cesta, Mark F.; Bonner, James C.] N Carolina State Univ, Dept Environm & Mol Toxicol, Raleigh, NC 27695 USA.
[Ryman-Rasmussen, Jessica P.; Tewksbury, Earl W.; Moss, Owen R.; Cesta, Mark F.; Wong, Brian A.; Bonner, James C.] Hamner Inst Hlth Sci, Res Triangle Pk, NC USA.
[Cesta, Mark F.] Natl Inst Environm Hlth Sci, Cellular & Mol Pathol Branch, Res Triangle Pk, NC USA.
RP Bonner, JC (reprint author), N Carolina State Univ, Dept Environm & Mol Toxicol, Box 7633, Raleigh, NC 27695 USA.
EM james_bonner@ncsu.edu
FU The American Chemistry Council's Long Range Research Initiative; The
Intramural Research Program of the National Institutes of Health;
National Institute of the Environmental Health Sciences; North Carolina
State University's College of Agricultural and Life Sciences
FX This study was funded by The American Chemistry Council's Long Range
Research Initiative provided to The Hamner Institutes for Health
Sciences, The Intramural Research Program of the National Institutes of
Health, National Institute of the Environmental Health Sciences, and
North Carolina State University's College of Agricultural and Life
Sciences.
NR 33
TC 122
Z9 123
U1 0
U2 8
PU AMER THORACIC SOC
PI NEW YORK
PA 1740 BROADWAY, NEW YORK, NY 10019-4374 USA
SN 1044-1549
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD MAR
PY 2009
VL 40
IS 3
BP 349
EP 358
DI 10.1165/rcmb.2008-0276OC
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA 412PC
UT WOS:000263735700012
PM 18787175
ER
PT J
AU Conolly, RB
Miller, FJ
Kimbell, JS
Janszen, D
AF Conolly, Rory B.
Miller, Frederick J.
Kimbell, Julia S.
Janszen, Derek
TI Formaldehyde Risk Assessment
SO ANNALS OF OCCUPATIONAL HYGIENE
LA English
DT Letter
C1 [Conolly, Rory B.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
[Miller, Frederick J.] Fred J Miller & Associates LLC, Cary, NC 27511 USA.
RP Conolly, RB (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, MD B205-01, Res Triangle Pk, NC 27711 USA.
EM conolly.rory@epa.gov; fjmiller@nc.rr.com; kimbell@thehamner.org
NR 0
TC 4
Z9 4
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0003-4878
J9 ANN OCCUP HYG
JI Ann. Occup. Hyg.
PD MAR
PY 2009
VL 53
IS 2
BP 181
EP 183
DI 10.1093/annhyg/men084
PG 3
WC Public, Environmental & Occupational Health; Toxicology
SC Public, Environmental & Occupational Health; Toxicology
GA 415OQ
UT WOS:000263943900009
PM 19174485
ER
PT J
AU Crump, KS
Chen, C
Fox, JF
Subramaniam, R
Van Landingham, C
AF Crump, Kenny S.
Chen, Chao
Fox, John F.
Subramaniam, Ravi
Van Landingham, Cynthia
TI Formaldehyde Risk Assessment Reply
SO ANNALS OF OCCUPATIONAL HYGIENE
LA English
DT Letter
ID INDUCED RESPIRATORY CANCER; SENSITIVITY-ANALYSIS; CARCINOGENICITY;
UNCERTAINTIES; MODELS; RAT
C1 [Crump, Kenny S.] Louisiana Tech Univ, Ruston, LA 71272 USA.
[Chen, Chao; Fox, John F.; Subramaniam, Ravi] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
[Van Landingham, Cynthia] ENVIRON Int Corp, Monroe, LA 71201 USA.
RP Crump, KS (reprint author), Louisiana Tech Univ, POB 10348, Ruston, LA 71272 USA.
NR 9
TC 4
Z9 4
U1 1
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0003-4878
J9 ANN OCCUP HYG
JI Ann. Occup. Hyg.
PD MAR
PY 2009
VL 53
IS 2
BP 184
EP 189
DI 10.1093/annhyg/men088
PG 6
WC Public, Environmental & Occupational Health; Toxicology
SC Public, Environmental & Occupational Health; Toxicology
GA 415OQ
UT WOS:000263943900010
ER
PT J
AU Haberg, SE
London, SJ
Stigum, H
Nafstad, P
Nystad, W
AF Haberg, S. E.
London, S. J.
Stigum, H.
Nafstad, P.
Nystad, W.
TI Folic acid supplements in pregnancy and early childhood respiratory
health
SO ARCHIVES OF DISEASE IN CHILDHOOD
LA English
DT Article
ID DNA METHYLATION; DIETARY-SUPPLEMENTS; REPRODUCTIVE AGE; NORWEGIAN
MOTHER; FOLATE; ASSOCIATION; COHORT; WOMEN; KNOWLEDGE; ATTITUDES
AB Background: Folate supplementation is recommended for pregnant women to reduce the risk of congenital malformations. Maternal intake of folate supplements during pregnancy might also influence childhood immune phenotypes via epigenetic mechanisms.
Objective: To investigate the relationship between folate supplements in pregnancy and risk of lower respiratory tract infections and wheeze in children up to 18 months of age. Methods: In the Norwegian Mother and Child Cohort Study, questionnaire data collected at several time points during pregnancy and after birth on 32 077 children born between 2000 and 2005 were used to assess the effects of folate supplements during pregnancy on respiratory outcomes up to 18 months of age, while accounting for other supplements in pregnancy and supplementation in infancy.
Results: Folate supplements in the first trimester were associated with increased risk of wheeze and respiratory tract infections up to 18 months of age. Adjusting for exposure later in pregnancy and in infancy, the relative risk for wheeze for children exposed to folic acid supplements in the first trimester was 1.06 (95% CI 1.03 to 1.10), the relative risk for lower respiratory tract infections was 1.09 (95% CI 1.02 to 1.15) and the relative risk for hospitalisations for lower respiratory tract infections was 1.24 (95% CI 1.09 to 1.41).
Conclusions: Folic acid supplements in pregnancy were associated with a slightly increased risk of wheeze and lower respiratory tract infections up to 18 months of age. The results suggest that methyl donors in the maternal diet during pregnancy may influence respiratory health in children consistent with epigenetic mechanisms.
C1 [Haberg, S. E.; Stigum, H.; Nafstad, P.; Nystad, W.] Norwegian Inst Publ Hlth, Div Epidemiol, NO-0403 Oslo, Norway.
[London, S. J.] Natl Inst Environm Hlth Sci, Epidemiol Branch, Natl Inst Hlth, Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
[London, S. J.] Natl Inst Environm Hlth Sci, Lab Resp Biol, Natl Inst Hlth, Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
[Nafstad, P.] Univ Oslo, Fac Med, Dept Community Hlth & Gen Practice, Oslo, Norway.
RP Haberg, SE (reprint author), Norwegian Inst Publ Hlth, Div Epidemiol, POB 4404, NO-0403 Oslo, Norway.
EM siri.haberg@fhi.no
OI London, Stephanie/0000-0003-4911-5290
FU Norwegian Association of Heart and Lung patients; Norwegian Foundation
for Health and Rehabilitation; Norwegian Ministry of Health, NIH/NIEHS
[N01-ES-85433]; NIH/NINDS [1 UO1 NS 047537-01]; Norwegian Research
Council/FUGE [151918/S10]
FX The study was supported by the Norwegian Association of Heart and Lung
patients with EXTRA funds from the Norwegian Foundation for Health and
Rehabilitation. The Norwegian Mother and Child Cohort Study is supported
by the Norwegian Ministry of Health, NIH/NIEHS (grant no. N01-ES-85433),
NIH/NINDS (grant no. 1 UO1 NS 047537-01) and the Norwegian Research
Council/FUGE (grant no. 151918/S10). The funding sources had no
involvement in study design; in the collection, analysis and
interpretation of data; in the writing of the report; or in the decision
to submit the paper for publication.
NR 28
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Z9 145
U1 0
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-9888
EI 1468-2044
J9 ARCH DIS CHILD
JI Arch. Dis. Child.
PD MAR
PY 2009
VL 94
IS 3
BP 180
EP 184
DI 10.1136/adc.2008.142448
PG 5
WC Pediatrics
SC Pediatrics
GA 410DR
UT WOS:000263557600003
PM 19052032
ER
PT J
AU Ozkaynak, H
Frey, HC
Burke, J
Pinder, RW
AF Oezkaynak, Haluk
Frey, H. Christopher
Burke, Janet
Pinder, Robert W.
TI Analysis of coupled model uncertainties in source-to-dose modeling of
human exposures to ambient air pollution: A PM2.5 case study
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Air quality model; Exposure model; Particulate matter; Variability;
Uncertainty
ID LAND-SURFACE MODEL; BOUNDARY-LAYER; PART I; PHILADELPHIA; PREDICTIONS;
MECHANISM; SYSTEM
AB Quantitative assessment of human exposures and health effects due to air pollution involve detailed characterization of impacts of air quality on exposure and dose. A key challenge is to integrate these three components on a consistent spatial and temporal basis taking into account linkages and feedbacks. The current state-of-practice for such assessments is to exercise emission, meteorology, air quality, exposure, and dose models separately, and to link them together by using the output of one model as input to the subsequent downstream model. Quantification of variability and uncertainty has been an important topic in the exposure assessment community for a number of years. Variability refers to differences in the value of a quantity (e.g., exposure) over time, space, or among individuals. Uncertainty refers to lack of knowledge regarding the true value of a quantity. An emerging challenge is how to quantify variability and uncertainty in integrated assessments over the source-to-close continuum by considering contributions from individual as well as linked components. For a case study of fine particulate matter (PM2.5) in North Carolina during July 2002, we characterize variability and uncertainty associated with each of the individual concentration, exposure and dose models that are linked, and use a conceptual framework to quantify and evaluate the implications of coupled model uncertainties. We find that the resulting overall uncertainties due to combined effects of both variability and uncertainty are smaller (usually by a factor of 3-4) than the crudely multiplied model-specific overall uncertainty ratios. Future research will need to examine the impact of potential dependencies among the model components by conducting a truly Coupled modeling analysis. Published by Elsevier Ltd.
C1 [Oezkaynak, Haluk; Burke, Janet; Pinder, Robert W.] US EPA, Natl Exposure Res Lab E205 01, Res Triangle Pk, NC 27711 USA.
[Frey, H. Christopher] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
RP Ozkaynak, H (reprint author), US EPA, Natl Exposure Res Lab E205 01, Res Triangle Pk, NC 27711 USA.
EM ozkaynak.haluk@epa.gov
RI Pinder, Robert/F-8252-2011;
OI Pinder, Robert/0000-0001-6390-7126; Frey, Henry/0000-0001-9450-0804
FU EPA/ORD/NERL
FX We are grateful to Drs. Alice Gilliland, David Holland, Markey Johnson
and Mr. Brad Schultz with EPA/ORD/NERL and to Dr. Steven Hanna for their
helpful comments on the manuscript, and to Dr. Lawrence W. Reiter
(EPA/ORD/NERL) for his support during this research.
NR 25
TC 20
Z9 20
U1 2
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD MAR
PY 2009
VL 43
IS 9
BP 1641
EP 1649
DI 10.1016/j.atmosenv.2008.12.008
PG 9
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 417IZ
UT WOS:000264071000006
PM 20041038
ER
PT J
AU Williams-DeVane, CR
Wolf, MA
Richard, AM
AF Williams-DeVane, ClarLynda R.
Wolf, Maritja A.
Richard, Ann M.
TI DSSTox chemical-index files for exposure-related experiments in
ArrayExpress and Gene Expression Omnibus: enabling toxico-chemogenomics
data linkages
SO BIOINFORMATICS
LA English
DT Article
AB The Distributed Structure-Searchable Toxicity (DSSTox) ARYEXP and GEOGSE files are newly published, structure-annotated files of the chemical-associated and chemical exposure-related summary experimental content contained in the ArrayExpress Repository and Gene Expression Omnibus (GEO) Series (based on data extracted on September 20, 2008). ARYEXP and GEOGSE contain 887 and 1064 unique chemical substances mapped to 1835 and 2381 chemical exposure-related experiment accession IDs, respectively. The standardized files allow one to assess, compare and search the chemical content in each resource, in the context of the larger DSSTox toxicology data network, as well as across large public cheminformatics resources such as PubChem (http://pubchem.ncbi.nlm.nih.gov).
C1 [Williams-DeVane, ClarLynda R.; Richard, Ann M.] US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Washington, DC USA.
[Wolf, Maritja A.] Lockheed Martin, Res Triangle Pk, NC 27711 USA.
RP Williams-DeVane, CR (reprint author), US EPA, Off Res & Dev, Natl Ctr Computat Toxicol, Washington, DC USA.
FU NCSU/EPA Cooperative Training Program in Environmental Sciences Research
[CT833235-01-0]
FX NCSU/EPA Cooperative Training Program in Environmental Sciences
Research, Training Agreement CT833235-01-0 with North Carolina State
University (to C. R. W.).
NR 3
TC 11
Z9 11
U1 2
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1367-4803
J9 BIOINFORMATICS
JI Bioinformatics
PD MAR 1
PY 2009
VL 25
IS 5
BP 692
EP 694
DI 10.1093/bioinformatics/btp042
PG 3
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Computer Science, Interdisciplinary Applications; Mathematical &
Computational Biology; Statistics & Probability
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Computer Science; Mathematical & Computational Biology; Mathematics
GA 413ZV
UT WOS:000263834600030
PM 19158160
ER
PT J
AU Jefferson, WN
Padilla-Banks, E
Goulding, EH
Lao, SPC
Newbold, RR
Williams, CJ
AF Jefferson, Wendy N.
Padilla-Banks, Elizabeth
Goulding, Eugenia H.
Lao, Shin-Ping C.
Newbold, Retha R.
Williams, Carmen J.
TI Neonatal Exposure to Genistein Disrupts Ability of Female Mouse
Reproductive Tract to Support Preimplantation Embryo Development and
Implantation
SO BIOLOGY OF REPRODUCTION
LA English
DT Article
DE development; early development; embryo; endocrine disruptor;
environment; estrogens; female reproductive tract; ovary; oviduct;
phytoestrogens; soy
ID OOCYTE NEST BREAKDOWN; PHYTOESTROGEN GENISTEIN; INFANT FORMULA;
IN-VITRO; SYSTEM; MICE; EXPRESSION; FOLLICLES; OVARY; RAT
AB Female mice treated neonatally with the phytoestrogen genistein (50 mg/kg/day) have multioocyte follicles, lack regular estrous cyclicity, and are infertile even after superovulation. To determine the cause of their infertility, we examined oocyte developmental competence and timing of embryo loss. Eggs obtained by superovulation of genistein-treated or control females were equally capable of being fertilized in vitro and cultured to the blastocyst stage. However, if eggs were fertilized in vivo, retrieved at the pronucleus stage, and cultured, there was a significant reduction in the percentage of embryos from genistein-treated females reaching the blastocyst stage. When these blastocysts were transferred to pseudopregnant recipients, the number of live pups produced was similar to that in controls. Preimplantation embryo development in vivo was examined by flushing embryos from the oviduct and/or uterus. Similar numbers of one-cell and two-cell embryos were obtained from genistein-treated and control females. However, significantly fewer embryos (<50%) were obtained from genistein-treated females on postcoital Days 3 and 4. To determine if neonatal genistein treatment altered the ability of the uterus to support implantation, blastocysts from control donors were transferred to control and genistein-treated pseudopregnant recipients. These experiments demonstrated that genistein-treated females are not capable of supporting normal implantation of control embryos. Taken together, these results suggest that oocytes from mice treated neonatally with genistein are developmentally competent; however, the oviductal environment and the uterus have abnormalities that contribute to the observed reproductive failure.
C1 [Jefferson, Wendy N.; Padilla-Banks, Elizabeth; Lao, Shin-Ping C.; Williams, Carmen J.] Natl Inst Environm Hlth Sci, Reprod Med Grp, Mol Toxicol Lab, Natl Inst Hlth, Res Triangle Pk, NC USA.
[Goulding, Eugenia H.] Natl Inst Environm Hlth Sci, Gamete Biol Sect, Mol Toxicol Lab, Natl Inst Hlth, Res Triangle Pk, NC USA.
[Jefferson, Wendy N.; Padilla-Banks, Elizabeth; Newbold, Retha R.] Natl Inst Environm Hlth Sci, Lab Reprod & Dev Toxicol, Mol Toxicol Lab, Natl Inst Hlth, Res Triangle Pk, NC USA.
[Jefferson, Wendy N.; Padilla-Banks, Elizabeth; Newbold, Retha R.] Natl Inst Environm Hlth Sci, Dev Endocrinol & Endocrine Disruptor Sect, Mol Toxicol Lab, Natl Inst Hlth, Res Triangle Pk, NC USA.
RP Williams, CJ (reprint author), NIEHS NIH DHHS, POB 12233, Res Triangle Pk, NC 27709 USA.
EM williamsc5@niehs.nih.gov
RI Williams, Carmen/E-2170-2013
OI Williams, Carmen/0000-0001-6440-7086
FU Intramural NIH HHS [Z99 ES999999]
NR 37
TC 46
Z9 51
U1 0
U2 2
PU SOC STUDY REPRODUCTION
PI MADISON
PA 1603 MONROE ST, MADISON, WI 53711-2021 USA
SN 0006-3363
J9 BIOL REPROD
JI Biol. Reprod.
PD MAR
PY 2009
VL 80
IS 3
BP 425
EP 431
DI 10.1095/biolreprod.108.073171
PG 7
WC Reproductive Biology
SC Reproductive Biology
GA 410TZ
UT WOS:000263602500005
PM 19005167
ER
PT J
AU Cao, HP
Lin, R
AF Cao, Heping
Lin, Rui
TI Quantitative Evaluation of His-Tag Purification and Immunoprecipitation
of Tristetraprolin and its Mutant Proteins from Transfected Human Cells
SO BIOTECHNOLOGY PROGRESS
LA English
DT Article
DE His-tag purification; immunoprecipitation; in vivo radiolabeling;
phosphorylation site; site-directed mutagenesis; tristetraprolin; zinc
finger protein
ID NECROSIS-FACTOR-ALPHA; MESSENGER-RNA DECAY; MOUSE 3T3-L1 ADIPOCYTES;
ZINC-FINGER PROTEINS; GENE-EXPRESSION; RECOMBINANT TRISTETRAPROLIN;
BINDING PROPERTIES; TNF-ALPHA; ELEMENT; SITE
AB Histidine (His)-tag is widely used for affinity purification of recombinant proteins, but the yield and purity of expressed proteins are quite different. Little information is available about quantitative evaluation of this procedure. The objective of this study was to evaluate His-tag procedure quantitatively and to compare it with immunoprecipitation using radiolabeled tristetraprolin (TTP), a zinc finger protein with anti-inflammatory property. Human embryonic kidney 293 cells were transfected with wild-type and nine mutant plasmids with single or multiple phosphorylation site mutation(s) in His-TTP. These proteins were expressed and mainly localized in the cytosol of transfected cells by immunocytochemistry and confocal microscopy. His-TTP proteins were purified by Ni-NTA beads with imidazole elution, or precipitated by TTP antibodies from transfected cells after being labeled with [(32)P]-orthophosphate. The results showed that (1) His-tag purification was more effective than immunoprecipitation for TTP purification; (2) mutations in TTP increased the yield of His-TTP by both purification procedures; and (3) mutations in TTP increased the binding affinity of mutant proteins for Ni-NTA beads. These findings suggest that bioengineering phosphorylation sites in proteins can increase the production of recombinant proteins. (C) 2009 American Institute of Chemical Engineers Biotechnol. Prog., 25: 461-467, 2009
C1 [Cao, Heping] ARS, Diet Genom & Immunol Lab, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD 20705 USA.
[Cao, Heping; Lin, Rui] Natl Inst Environm Hlth Sci, NIH, US Dept HHS, Res Triangle Pk, NC 27709 USA.
RP Cao, HP (reprint author), ARS, Diet Genom & Immunol Lab, Beltsville Human Nutr Res Ctr, USDA, 10300 Baltimore Ave, Beltsville, MD 20705 USA.
EM peacetd2003@yahoo.com; ruilin@peacetd.com
FU NIH; National Institute of Environmental Health Sciences; USDA-ARS Human
Nutrition Research Program
FX This work was supported in part by the Intramural Research Program of
the NIH, National Institute of Environmental Health Sciences, and
USDA-ARS Human Nutrition Research Program. The authors thank Dr. Perry
J. Blackshear (NIEHS/NIH) for his generous support, Dr. Wi S. Lai for
the wild-type and S197A mutant TTP plasmids, Ms. Elizabeth A. Kennington
(NIH/NIEHS) for her assistance on radiolabelling, and Dr. Joseph F.
Urban Jr. (USDA/ARS) for his helpful comments on the manuscript.
NR 43
TC 5
Z9 6
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 8756-7938
J9 BIOTECHNOL PROGR
JI Biotechnol. Prog.
PD MAR-APR
PY 2009
VL 25
IS 2
BP 461
EP 467
DI 10.1021/bp.121
PG 7
WC Biotechnology & Applied Microbiology; Food Science & Technology
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 438RI
UT WOS:000265572700020
PM 19330843
ER
PT J
AU Goldstein, JA
Blaisdell, JA
Limdi, NA
AF Goldstein, J. A.
Blaisdell, J. A.
Limdi, N. A.
TI A potentially deleterious new CYP2C9 polymorphism identified in an
African American patient with major hemorrhage on warfarin therapy
SO BLOOD CELLS MOLECULES AND DISEASES
LA English
DT Letter
ID FUNCTIONAL-CHARACTERIZATION; EUROPEAN-AMERICANS; VARIANT; GENE
C1 [Limdi, N. A.] Univ Alabama, Dept Neurol, Birmingham, AL 35294 USA.
[Goldstein, J. A.; Blaisdell, J. A.] Natl Inst Environm Hlth Sci, Lab Pharmacol & Chem, Res Triangle Pk, NC 27709 USA.
RP Limdi, NA (reprint author), Univ Alabama, Dept Neurol, 1719 6th Ave S,CIRC-312, Birmingham, AL 35294 USA.
EM nlimdi@uab.edu
RI Goldstein, Joyce/A-6681-2012
FU Intramural NIH HHS [ZIA ES021024-28]; NINDS NIH HHS [K23 NS045598-05,
K23 NS045598]
NR 13
TC 7
Z9 7
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1079-9796
J9 BLOOD CELL MOL DIS
JI Blood Cells Mol. Dis.
PD MAR-APR
PY 2009
VL 42
IS 2
BP 155
EP 158
DI 10.1016/j.bcmd.2008.10.011
PG 4
WC Hematology
SC Hematology
GA 409KJ
UT WOS:000263504300013
PM 19083245
ER
PT J
AU Mukherjee, B
Wrenn, BA
AF Mukherjee, Biplab
Wrenn, Brian A.
TI Size distribution as a measure of dispersant performance
SO CANADIAN JOURNAL OF CIVIL ENGINEERING
LA English
DT Article
DE crude oil; chemical dispersion; dispersant performance testing; droplet
size distributions; baffled flask test
ID EFFECTIVENESS PROTOCOL; CRUDE-OIL; BIODEGRADATION
AB Study of the chemical dispersion of crude oil using size distribution methods can provide important information needed for oil-spill response strategy, which is lacking in the more commonly used mass-concentration methods. Therefore, identification of a reliable method or methods that can provide accurate information regarding droplet size and the mass of oil dispersed is necessary. This research compared four such methods. Gravimetric analysis of the oil mass dispersed was biased low due to loss of volatile components, whereas UV spectroscopy provided accurate results. Size-distribution data obtained using an optical particle counter (OPC) produced accurate estimates of oil mass dispersed, but microscopic examination produced inaccurate and poorly reproducible estimates. Although size-distribution metrics (e. g., estimates of the mean diameter of the size distribution) produced by the two methods were similar, microscopic examination gave unreliable estimates of the number concentration of dispersed oil droplets due to the relatively small number of observations relative to the OPC.
C1 [Mukherjee, Biplab; Wrenn, Brian A.] Washington Univ, Dept Energy Environm & Chem Engn, St Louis, MO 63130 USA.
RP Mukherjee, B (reprint author), US EPA, Ecosyst Res Div, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM mukherjee.biplab@epa.gov
NR 22
TC 6
Z9 6
U1 0
U2 7
PU NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS
PI OTTAWA
PA BUILDING M 55, OTTAWA, ON K1A 0R6, CANADA
SN 0315-1468
J9 CAN J CIVIL ENG
JI Can. J. Civ. Eng.
PD MAR
PY 2009
VL 36
IS 3
BP 540
EP 549
DI 10.1139/L08-147
PG 10
WC Engineering, Civil
SC Engineering
GA 439CO
UT WOS:000265605400018
ER
PT J
AU Vulimiri, SV
Misra, M
Hamm, JT
Mitchell, M
Berger, A
AF Vulimiri, Suryanarayana V.
Misra, Manoj
Hamm, Jonathan T.
Mitchell, Matthew
Berger, Alvin
TI Effects of Mainstream Cigarette Smoke on the Global Metabolome of Human
Lung Epithelial Cells
SO CHEMICAL RESEARCH IN TOXICOLOGY
LA English
DT Article
ID IN-VITRO; OXIDATIVE STRESS; GLUTATHIONE; EXPRESSION; EXTRACT;
PROLIFERATION; CONDENSATE; INDUCTION; APOPTOSIS; RELEASE
AB Metabolomics is a technology for identifying and quantifying numerous biochemicals across metabolic pathways. Using this approach, we explored changes in biochemical profiles of human alveolar epithelial carcinoma (A549) cells following in vitro exposure to mainstream whole smoke (WS) aerosol as well as to wet total particulate matter (WTPM) or gas/vapor phase (GVP), the two constituent phases of WS from 2R4F Kentucky reference cigarettes. A549 cells were exposed to WTPM or GVP (expressed as WTPM mass equivalent GVP volumes) at 0, 5, 25, or 50 mu g/mL or to WS from zero, two, four, and six cigarettes for 1 or 24 h. Cell pellets were analyzed for perturbations in biochemical profiles, with named biochemicals measured, analyzed, and reported in a heat map format, along with biochemical and physiological interpretations (mSelect, Metabolon Inc.). Both WTPM and GVP exposures likely decreased glycolysis (based on decreased glycolytic intermediaries) and increased oxidative stress and cell damage. Alterations in the Krebs cycle and the urea cycle were unique to WTPM exposure, while induction of hexosamines and alterations in lipid metabolism were unique to GVP exposure. WS altered glutathione (GSH) levels, enhanced polyamine and pantothenate levels, likely increased beta-oxidation of fatty acids, and increased phospholipid degradation marked by an increase in phosphoethanolamine. GSH, glutamine, and pantothenate showed the most significant changes with cigarette smoke exposure in A549 cells based on principal component analysis. Many of the changed biochemicals were previously reported to be altered by cigarette exposure, but the global metabolomic approach offers the advantage of observing changes to hundreds of biochemicals in a single experiment and the possibility for new discoveries. The metabolomic approach may thus be used as a screening tool to evaluate conventional and novel tobacco products offering the potential to reduce risks of smoking.
C1 [Vulimiri, Suryanarayana V.; Misra, Manoj; Hamm, Jonathan T.] Lorillard Tobacco Co, AW Spears Res Ctr, Greensboro, NC 27420 USA.
[Mitchell, Matthew; Berger, Alvin] Metabolon, Durham, NC 27713 USA.
RP Vulimiri, SV (reprint author), US EPA, Off Res & Dev, Natl Ctr Environm Risk Assessment, Mail Code 8623P,1200 Penn Ave NW, Washington, DC 20460 USA.
EM suryvulimiri@gmail.com
OI Vulimiri, Suryanarayana/0000-0003-3734-0036; Mitchell,
Matthew/0000-0002-2681-4091
NR 39
TC 43
Z9 44
U1 3
U2 42
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0893-228X
EI 1520-5010
J9 CHEM RES TOXICOL
JI Chem. Res. Toxicol.
PD MAR
PY 2009
VL 22
IS 3
BP 492
EP 503
DI 10.1021/tx8003246
PG 12
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
SC Pharmacology & Pharmacy; Chemistry; Toxicology
GA 420SY
UT WOS:000264310700013
PM 19161311
ER
PT J
AU Loganathan, B
Phillips, M
Mowery, H
Jones-Lepp, TL
AF Loganathan, Bommanna
Phillips, Malia
Mowery, Holly
Jones-Lepp, Tammy L.
TI Contamination profiles and mass loadings of macrolide antibiotics and
illicit drugs from a small urban wastewater treatment plant
SO CHEMOSPHERE
LA English
DT Article
DE PPCPS; Macrolide antibiotics; Methamphetamine; Ecstasy; Wastewater;
Kentucky
ID WIDESPREAD SEXUAL DISRUPTION; PERSONAL CARE PRODUCTS; WILD FISH;
PHARMACEUTICALS; SPECTROMETRY; EXPOSURE; FATE; ENVIRONMENT; ORGANISMS;
KENTUCKY
AB Information is limited regarding Sources, distribution, environmental behavior, and fate of prescribed and illicit drugs. Wastewater treatment plant (WWTP) effluents can be one of the sources of pharmaceutical and personal care products (PPCP) into streams, rivers and lakes. The objective of this study was to determine the contamination profiles and mass loadings of urobilin (a chemical marker of human waste), macrolide antibiotics (azithromycin, clarithromycin, roxithromycin), and two drugs of abuse (methamphetamine and ecstasy), from a small (<19 mega liters day(-1), equivalent to <5 million gallons per day) wastewater treatment plant in southwestern Kentucky. The concentrations of azithromycin, clarithromycin, methamphetamine and ecstasy in wastewater samples varied widely, ranging from non-detects to 300 ng L(-1). Among the macrolide antibiotics analyzed, azithromycin was consistently detected in influent and effluent samples. in general, influent samples contained relatively higher concentrations of the analytes than the effluents. Based on the daily flow rates and an average concentration of 17.5 ng L(-1) in the effluent, the estimated discharge of azithromycin was 200 mg day(-1) (range 63-400 mg day(-1)). Removal efficiency of the detected analytes from this WWTP were in the following order: Urobilin > nnethamphetamine > azithromycin with percentages of removal of 99.9%, 54.5% and 47%, respectively, indicating that the azithromycin and methamphetamine are relatively more recalcitrant than others and have potential for entering receiving waters. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Jones-Lepp, Tammy L.] US EPA, ORD, NERL, ESD, Las Vegas, NV 89193 USA.
[Loganathan, Bommanna; Phillips, Malia; Mowery, Holly] Murray State Univ, Dept Chem, Murray, KY 42071 USA.
[Loganathan, Bommanna; Phillips, Malia; Mowery, Holly] Murray State Univ, Ctr Reservoir Res, Murray, KY 42071 USA.
RP Jones-Lepp, TL (reprint author), US EPA, ORD, NERL, ESD, POB 93478, Las Vegas, NV 89193 USA.
EM jones-lepp.tammy@epa.gov
RI Loganathan, Bommanna/A-5375-2012
OI Loganathan, Bommanna/0000-0001-5769-2579
NR 37
TC 81
Z9 86
U1 5
U2 60
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
J9 CHEMOSPHERE
JI Chemosphere
PD MAR
PY 2009
VL 75
IS 1
BP 70
EP 77
DI 10.1016/j.chemosphere.2008.11.047
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 430RN
UT WOS:000265006300010
PM 19121838
ER
PT J
AU Engel-Cox, J
Van Houten, B
Phelps, J
Rose, S
AF Engel-Cox, Jill
Van Houten, Bennett
Phelps, Jerry
Rose, Shyanika
TI Conceptual model of comprehensive research metrics for improved human
health and environment
SO CIENCIA & SAUDE COLETIVA
LA English
DT Reprint
DE Conceptual model development; Environmental health research; Metrics
development; Performance measurement; Research impact evaluation
ID PARTICULATE AIR-POLLUTION; EPIDEMIOLOGIC EVIDENCE; MORTALITY; CHILDREN;
LEAD
AB Performance measurement predominantly consisted of near-term outputs measured through bibliometrics, but the recent focus is on accountability for investment based on long-term outcomes. Our objective is to build a logic model and associated metrics through which to measure the contribution of environmental health research programs to improvements in human health, the environment, and the economy. We developed a logic model that defines the components and linkages between extramural environmental health research grant programs and the outputs and outcomes related to health and social welfare, environmental quality and sustainability, economics, and quality of life, focusing on the environmental health research portfolio of the National Institute of Environmental Health Sciences (NIEHS) Division of Extramural Research and Training and delineates pathways for contributions by five types of institutional partners in the research process. The model is being applied to specific NIEHS research applications and the broader research community. We briefly discuss two examples and discuss the strengths and limits of outcome- based evaluation of research programs.
C1 [Engel-Cox, Jill] Battelle Mem Inst, Arlington, VA 22201 USA.
[Van Houten, Bennett; Phelps, Jerry] Natl Inst Environm Hlth Sci, Div Extramural Res & Training, NIH, Dept Hlth & Human Serv, Res Triangle Pk, NC USA.
[Rose, Shyanika] Battelle Mem Inst, Durham, NC USA.
RP Engel-Cox, J (reprint author), Battelle Mem Inst, 2101 Wilson Blvd,Suite 800, Arlington, VA 22201 USA.
EM engelcoxj@battelle.org
NR 36
TC 2
Z9 2
U1 1
U2 6
PU ABRASCO
PI RIO DE JANEIRO
PA RUA HESPERIA, 16-PARTE MANGUINHOS, RIO DE JANEIRO, 21050-040, BRAZIL
SN 1413-8123
J9 CIENC SAUDE COLETIVA
JI Cienc. Saude Coletiva
PD MAR-APR
PY 2009
VL 14
IS 2
BP 519
EP 531
PG 13
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 404AE
UT WOS:000263122300020
PM 19197426
ER
PT J
AU Riedl, MA
Saxon, A
Diaz-Sanchez, D
AF Riedl, Marc A.
Saxon, Andrew
Diaz-Sanchez, David
TI Oral sulforaphane increases Phase II antioxidant enzymes in the human
upper airway
SO CLINICAL IMMUNOLOGY
LA English
DT Article
DE Oxidative stress; Antioxidants; Asthma; Allergic inflammation;
Sulforaphane; Phase II enzymes; Air pollution
ID DIESEL EXHAUST PARTICLES; OXIDATIVE STRESS; BROCCOLI SPROUTS;
QUANTITATIVE-DETERMINATION; CRUCIFEROUS VEGETABLES; NASAL CHALLENGE; IGE
PRODUCTION; IN-VIVO; ISOTHIOCYANATES; ASTHMA
AB Background: Cellular oxidative stress is an important factor in asthma and is thought to be the principle mechanism by which oxidant pollutants such as ozone and particulates mediate their pro-inflammatory effects. Endogenous Phase II enzymes abrogate oxidative stress through the scavenging of reactive oxygen species and metabolism of reactive chemicals.
Objective: We conducted a placebo-controlled dose escalation trial to investigate the in vivo effects of sulforaphane, a naturally occurring potent inducer of Phase II enzymes, on the expression of glutathione-s-transferase M1 (GSTM1), glutathione-s-transferase P1 (GSTP1), NADPH quinone oxidoreductase (NQO1), and hemoxygenase-1 (HO-1) in the upper airway of human subjects.
Methods: Study subjects consumed oral sulforaphane doses contained in a standardized broccoli sprout homogenate (BSH). RNA expression for selected Phase II enzymes was measured in nasal lavage cells by RT-PCR before and after sulforaphane dosing.
Results: All subjects tolerated oral sulforaphane dosing without significant adverse events. Increased Phase II enzyme expression in nasal lavage cells occurred in a dose-dependent manner with maximal enzyme induction observed at the highest dose of 200 g broccoli sprouts prepared as BSH. Significant increases were seen in all sentinel Phase II enzymes RNA expression compared to baseline. Phase II enzyme induction was not seen with ingestion of non-sulforaphane containing alfalfa sprouts.
C1 [Riedl, Marc A.; Saxon, Andrew] Univ Calif Los Angeles, David Geffen Sch Med, Hart & Louis Lab, Dept Med, Los Angeles, CA 90095 USA.
[Diaz-Sanchez, David] US EPA, Human Studies Div, Chapel Hill, NC 27599 USA.
RP Riedl, MA (reprint author), Univ Calif Los Angeles, David Geffen Sch Med, Div Pulm & Crit Care Med, Ctr Hlth Sci 37 131, 10833 Conte Ave, Los Angeles, CA 90095 USA.
EM mriedl@mednet.ucla.edu
FU NCRR NIH HHS [K12 RR017611, K12 RR017611-05]; NIAID NIH HHS [P01
AI050495, P01 AI050495-05]; NIEHS NIH HHS [P01 ES009581,
5P01ES09581-10]; PHS HHS [K12 R011 7611]
NR 48
TC 93
Z9 98
U1 1
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1521-6616
J9 CLIN IMMUNOL
JI Clin. Immunol.
PD MAR
PY 2009
VL 130
IS 3
BP 244
EP 251
DI 10.1016/j.clim.2008.10.007
PG 8
WC Immunology
SC Immunology
GA 409UD
UT WOS:000263530400002
PM 19028145
ER
PT J
AU Hobbie, KR
DeAngelo, AB
King, LC
Winn, RN
Law, M
AF Hobbie, Kristen R.
DeAngelo, Anthony B.
King, Leon C.
Winn, Richard N.
Law, McHugh
TI Toward a molecular equivalent dose: Use of the medaka model in
comparative risk assessment
SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT 4th Conference on Aquatic Animal Models of Human Disease
CY JAN 31-FEB 03, 2008
CL Duke Univ, Durham, NC
SP Nicholas Sch Environm
HO Duke Univ
DE Risk assessment; Dose-response; DNA; Medaka; cll; Mutation; Adduct; DMN;
Nitrosamines
ID N-NITROSODIMETHYLAMINE NDMA; BLUE(R) TRANSGENIC MICE; ORYZIAS-LATIPES;
DNA-ADDUCTS; MUTATION SPECTRA; O-6-METHYLGUANINE-DNA METHYLTRANSFERASE;
BACTERIOPHAGE-LAMBDA; MUTANT FREQUENCIES; CHRONIC INGESTION; CHRONIC
EXPOSURE
AB Recent changes in the risk assessment landscape underscore the need to be able to compare the results of toxicity and dose-response testing between a growing list of animal models and, quite possibly, an array of in vitro screening assays. How do we compare test results for a given compound between vastly different species? For example, what dose level in the ambient water of a small fish model would be equivalent to 10 ppm of a given compound in the rat's drinking water? Where do we begin? To initially address these questions, and in order to compare dose-response tests in a standard rodent model with a fish model, we used the concept of molecular dose. Assays that quantify types of DNA damage that are directly relevant to carcinogenesis integrate the factors such as chemical exposure, uptake, distribution, metabolism, etc. that tend to vary so widely between different phyletic levels. We performed parallel exposures in F344 rats and Japanese medaka (Oryzias latipes) to the alkylating hepatocarcinogen, dimethylnitrosamine (DMN). In both models, we measured the DNA adducts 8-hydroxyguanine, N(7)-methylguanine and O(6)-methylguanine in the liver; mutation frequency using lambda cll transgenic medaka and lambda cll transgenic (Big Blue (R)) rats; and early morphological changes in the livers of both models using histopathology and immunohistochemistry. Pulse dose levels in fish were 0, 10, 25, 50, or 100 ppm DMN in the ambient water for 14 days. Since rats are reported to be especially sensitive to DMN, they received 0, 0.1, 1.5. 10, or 25 ppm DMN in the drinking water for the same time period. While liver DNA adduct concentrations were similar in magnitude, mutant frequencies in the DMN-exposed medaka were up to 20 times higher than in the Big Blue rats. Future work with other compounds will generate a more complete picture of comparative dose response between different phyletic levels and will help guide risk assessors using "alternative" models. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Hobbie, Kristen R.; Law, McHugh] N Carolina State Univ, Coll Vet Med, Comparat Biomed Sci Program, Raleigh, NC 27606 USA.
[Hobbie, Kristen R.; Law, McHugh] N Carolina State Univ, Coll Vet Med, Ctr Comparat Med & Translat Res, Raleigh, NC 27606 USA.
[Hobbie, Kristen R.] Integrated Lab Syst Inc, Res Triangle Pk, NC USA.
[DeAngelo, Anthony B.; King, Leon C.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC USA.
[Winn, Richard N.] Univ Georgia, Aquat Biotechnol & Environm Lab, Wamell Sch Forestry & Nat Resources, Athens, GA 30602 USA.
RP Law, M (reprint author), N Carolina State Univ, Coll Vet Med, Comparat Biomed Sci Program, 4700 Hillsborough St, Raleigh, NC 27606 USA.
EM mac_law@ncsu.edu
NR 40
TC 8
Z9 8
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1532-0456
J9 COMP BIOCHEM PHYS C
JI Comp. Biochem. Physiol. C-Toxicol. Pharmacol.
PD MAR
PY 2009
VL 149
IS 2
BP 141
EP 151
DI 10.1016/j.cbpc.2008.07.013
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
Toxicology; Zoology
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
Toxicology; Zoology
GA 419NG
UT WOS:000264225700004
PM 18722551
ER
PT J
AU Broussard, GW
Norris, MB
Schwindt, AR
Fournie, JW
Winn, RN
Kent, ML
Ennis, DG
AF Broussard, Gregory W.
Norris, Michelle B.
Schwindt, Adam R.
Fournie, John W.
Winn, Richard N.
Kent, Michael L.
Ennis, Don G.
TI Chronic Mycobacterium marinum infection acts as a tumor promoter in
Japanese Medaka (Oryzias latipes)
SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT 4th Conference on Aquatic Animal Models of Human Disease
CY JAN 31-FEB 03, 2008
CL Duke Univ, Durham, NC
SP Nicholas Sch Environm
HO Duke Univ
DE Benzo[a]pyrene; Carcinogenesis; Hepatic neoplasia; Inflammation; Oryzias
latipes; Tuberculosis; Non-tuberculosis mycobacteria
ID HELICOBACTER-PYLORI INFECTION; SQUAMOUS-CELL CARCINOMA; ZEBRAFISH
DANIO-RERIO; LUNG-CANCER; RESEARCH FACILITIES; NONSMOKING WOMEN;
BLADDER-CANCER; TARGET-CELLS; BURULI ULCER; DNA-DAMAGE
AB An accumulating body of research indicates there is an increased cancer risk associated with chronic infections. The genus Mycobacterium contains a number of species, including M. tuberculosis, which mount chronic infections and have been implicated in higher cancer risk. Several non-tuberculosis mycobacterial species, including M. marinum, are known to cause chronic infections in fish and like human tuberculosis, often go undetected. The elevated carcinogenic potential for fish colonies infected with Mycobacterium spp. could have far reaching implications because fish models are widely used to study human diseases. Japanese medaka (Oryzias latipes) is an established laboratory fish model for toxicology, mutagenesis, and carcinogenesis; and produces a chronic tuberculosis-like disease when infected by M. marinum. We examined the role that chronic mycobacterial infections play in cancer risk for medaka. Experimental M. marinum infections of medaka alone did not increase the mutational loads or proliferative lesion incidence in all tissues examined. However, we showed that chronic M. marinum infections increased hepatocellular proliferative lesions in fish also exposed to low doses of the mutagen benzo[a]pyrene. These results indicate that chronic mycobacterial infections of medaka are acting as tumor promoters and thereby suggest increased human risks for cancer promotion in human populations burdened with chronic tuberculosis infections. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Broussard, Gregory W.; Ennis, Don G.] Univ SW Louisiana, Dept Biol, Lafayette, LA 70504 USA.
[Norris, Michelle B.; Winn, Richard N.] Univ Georgia, Warnell Sch Forestry & Nat Resources, Aquat Biotechnol & Environm Lab, Athens, GA 30602 USA.
[Schwindt, Adam R.; Kent, Michael L.] Oregon State Univ, Ctr Fish Dis Res, Dept Microbiol, Corvallis, OR 97331 USA.
[Fournie, John W.] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP Ennis, DG (reprint author), Univ SW Louisiana, Dept Biol, POB 42451, Lafayette, LA 70504 USA.
EM dge5893@louisiana.edu
FU NCRR NIH HHS [RR11733, R24 RR011733]; NIAID NIH HHS [5R21AI055964-01,
R21 AI055964, R21 AI055964-02]; NIEHS NIH HHS [P30 ES003850, P30
ES03850]
NR 77
TC 15
Z9 15
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1532-0456
J9 COMP BIOCHEM PHYS C
JI Comp. Biochem. Physiol. C-Toxicol. Pharmacol.
PD MAR
PY 2009
VL 149
IS 2
BP 152
EP 160
DI 10.1016/j.cbpc.2008.09.011
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
Toxicology; Zoology
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
Toxicology; Zoology
GA 419NG
UT WOS:000264225700005
PM 18929684
ER
PT J
AU Spitsbergen, JM
Blazer, VS
Bowser, PR
Cheng, KC
Cooper, KR
Cooper, TK
Frasca, S
Groman, DB
Harper, CM
Law, JM
Marty, GD
Smolowitz, RM
Leger, JS
Wolf, DC
Wolf, JC
AF Spitsbergen, Jan M.
Blazer, Vicki S.
Bowser, Paul R.
Cheng, Keith C.
Cooper, Keith R.
Cooper, Timothy K.
Frasca, Salvatore, Jr.
Groman, David B.
Harper, Claudia M.
Law, Jerry M. (Mac)
Marty, Gary D.
Smolowitz, Roxanna M.
Leger, Judy St.
Wolf, Douglas C.
Wolf, Jeffrey C.
TI Finfish and aquatic invertebrate pathology resources for now and the
future
SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT 4th Conference on Aquatic Animal Models of Human Disease
CY JAN 31-FEB 03, 2008
CL Duke Univ, Durham, NC
SP Nicholas Sch Environm
HO Duke Univ
DE Fish pathology; Aquatic model; Pathology training program; Invertebrate
pathology; Standardized diagnostic criteria; Environmental sentinel;
Histopathology; Aquatic animal medicine
ID MEDAKA ORYZIAS-LATIPES; DIAGNOSTIC-CRITERIA; ZEBRAFISH RESEARCH;
JAPANESE MEDAKA; DRUG DISCOVERY; MODEL ORGANISM; HUMAN-DISEASE; MUTANT;
ECHINODERMATA; HISTOLOGY
AB Utilization of finfish and aquatic invertebrates in biomedical research and as environmental sentinels has grown dramatically in recent decades. Likewise the aquaculture of finfish and invertebrates has expanded rapidly worldwide as populations of some aquatic food species and threatened or endangered aquatic species have plummeted due to overharvesting or habitat degradation. This increasing intensive culture and use of aquatic species has heightened the importance of maintaining a sophisticated understanding of pathology of various organ systems of these diverse species. Yet, except for selected species long cultivated in aquaculture, pathology databases and the workforce of highly trained pathologists lag behind those available for most laboratory animals and domestic mammalian and avian species. Several factors must change to maximize the use, understanding, and protection of important aquatic species: 1) improvements in databases of abnormalities across species; 2) standardization of diagnostic criteria for proliferative and nonproliferative lesions; and 3) more uniform and rigorous training in aquatic morphologic pathology. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Spitsbergen, Jan M.] Oregon State Univ, Ctr Fish Dis Res, Corvallis, OR 97331 USA.
[Spitsbergen, Jan M.] Oregon State Univ, Marine & Freshwater Biomed Sci Ctr, Corvallis, OR 97331 USA.
[Blazer, Vicki S.] US Geol Survey, Natl Fish Hlth Res Lab, Kearneysville, WV 25430 USA.
[Bowser, Paul R.] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA.
[Cheng, Keith C.] Penn State Coll Med, Div Expt Pathol, Jake Gittlen Canc Res Fdn, Hershey, PA 17033 USA.
[Cooper, Keith R.] Rutgers State Univ, Dept Biochem & Microbiol, New Brunswick, NJ 08901 USA.
[Cooper, Timothy K.] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Comparat Med, Hershey, PA 17033 USA.
[Frasca, Salvatore, Jr.] Univ Connecticut, Dept Pathobiol & Vet Sci, Storrs, CT 06269 USA.
[Groman, David B.] Univ Prince Edward Isl, Atlantic Vet Coll, Aquat Diagnost Serv, Charlottetown, PE C1A 4P3, Canada.
[Harper, Claudia M.] Amgen Inc, Preclin Div, Cambridge, MA 02139 USA.
[Law, Jerry M. (Mac)] N Carolina State Univ, Coll Vet Med, Raleigh, NC 27606 USA.
[Marty, Gary D.] BC MAL, Ctr Anim Hlth, Abbotsford, BC V3G 2M3, Canada.
[Smolowitz, Roxanna M.] Cent Wharf, Anim Hlth, New England Aquarium, Boston, MA 02110 USA.
[Leger, Judy St.] Sea World San Diego, Pathol, San Diego, CA 92109 USA.
[Wolf, Douglas C.] US EPA, Res Triangle Pk, NC 27711 USA.
[Wolf, Jeffrey C.] Expt Pathology Labs Inc, Sterling, VA 20167 USA.
RP Spitsbergen, JM (reprint author), Oregon State Univ, Ctr Fish Dis Res, 220 Nash Hall, Corvallis, OR 97331 USA.
EM spitsbej@onid.orst.edu
RI Cheng, Keith/B-6506-2011
FU NCRR NIH HHS [RR12546, P40 RR012546, R24 RR017441, RR017441]; NIEHS NIH
HHS [ES00210, ES03850, P30 ES000210, P30 ES003850, R21 ES013124-01A1,
R21 ES013124-02]
NR 141
TC 4
Z9 4
U1 2
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1532-0456
J9 COMP BIOCHEM PHYS C
JI Comp. Biochem. Physiol. C-Toxicol. Pharmacol.
PD MAR
PY 2009
VL 149
IS 2
BP 249
EP 257
DI 10.1016/j.cbpc.2008.10.002
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
Toxicology; Zoology
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
Toxicology; Zoology
GA 419NG
UT WOS:000264225700017
PM 18948226
ER
PT J
AU Blocksom, KA
Johnson, BR
AF Blocksom, K. A.
Johnson, B. R.
TI Development of a regional macroinvertebrate index for large river
bioassessment
SO ECOLOGICAL INDICATORS
LA English
DT Article
DE Non-wadeable; Upper Midwest; Least disturbed condition; Biological
indicator
ID ATLANTIC HIGHLANDS STREAMS; ASSESSING BIOTIC INTEGRITY; BENTHIC
MACROINVERTEBRATES; MULTIMETRIC INDEX; UNITED-STATES
AB Large river bioassessment protocols lag far behind those of wadeable streams and often rely on fish assemblages of individual rivers. We developed a regional macroinvertebrate index and assessed relative condition of six large river tributaries to the upper Mississippi and Ohio rivers, Midwest USA. In 2004 and 2005, benthic macroinvertebrates, water chemistry, and habitat data were collected from randomly selected sites on each of the St. Croix, Wisconsin, Minnesota, Scioto, Wabash, and Illinois rivers. We first identified the human disturbance gradient using principal components analysis (PCA) of abiotic data. From the PCA, least disturbed sites showed strong separation from stressed sites along a gradient contrasting high water clarity, canopy cover, habitat scores, and plant-based substrates at one end and higher conductivity and nutrient concentrations at the other. Evaluation of 97 benthic metrics identified those with good range, responsiveness, and relative scope of impairment, as well as redundancies with other metrics. The final index was composed of Diptera taxa richness, EPT taxa richness, Coleoptera taxa richness, percent oligochaete and leech taxa, percent collector-filterer individuals, predator taxa richness, percent burrower taxa, tolerant taxa richness, and percent facultative individuals. Each of the selected metrics was scored using upper and lower thresholds based on all sites, and averaging across the nine metric scores, we obtained the Non-wadeable Macroinvertebrate Assemblage Condition Index (NMACI). The NMACI showed a strong response to disturbance using a validation data set and was highly correlated with non-metric multidimensional scaling (NMDS) ordination axes of benthic taxa. The cumulative distribution function of index scores for each river showed qualitative differences in condition among rivers. NMACI scores were highest for the federally protected St. Croix River and lowest for the Illinois River. other rivers were intermediate and generally reflected the mixture of land use types within individual basins. Use of regional reference sites, though setting a high level of expectation, provides a valuable frame of reference for the potential of large river benthic communities that will aid management and restoration efforts. Published by Elsevier Ltd.
C1 [Blocksom, K. A.; Johnson, B. R.] US EPA, Natl Exposure Res Lab, Cincinnati, OH 45268 USA.
RP Blocksom, KA (reprint author), US EPA, Natl Exposure Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM blocksom.karen@epa.gov
FU United States Environmental Protection Agency; EPA Region 5
FX The United States Environmental Protection Agency through its office of
Research and Development funded and managed the research described here.
It has been subjected to the Agency's administrative review and approved
for publication. We thank Ed Hammer and David Macarus from EPA Region 5
for their support of this study through the U.S. EPA's Regional Methods
Program. The field work, laboratory processing and analysis of samples,
and ISIS work for this study were carried out under contract number
EP-D-06-096 by numerous Dynamac personnel, including Mark Berninger,
Doug Noonan, Erica Grimmett, Bill Thoeny, Paul Grimmett, Molly Reif, and
many others. Mention of trade names or commercial products does not
constitute endorsement or recommendation for use. Thanks to Joe
Flotemersch and two anonymous reviewers of earlier drafts of this
manuscript for valuable comments and suggestions.
NR 40
TC 30
Z9 31
U1 2
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1470-160X
J9 ECOL INDIC
JI Ecol. Indic.
PD MAR
PY 2009
VL 9
IS 2
BP 313
EP 328
DI 10.1016/j.ecolind.2008.05.005
PG 16
WC Biodiversity Conservation; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 378CI
UT WOS:000261298300010
ER
PT J
AU Lawler, JJ
Shafer, SL
White, D
Kareiva, P
Maurer, EP
Blaustein, AR
Bartlein, PJ
AF Lawler, Joshua J.
Shafer, Sarah L.
White, Denis
Kareiva, Peter
Maurer, Edwin P.
Blaustein, Andrew R.
Bartlein, Patrick J.
TI Projected climate-induced faunal change in the Western Hemisphere
SO ECOLOGY
LA English
DT Article
DE amphibians; birds; climate change; climate envelope models; future
projections; mammals; range shifts; species distributions
ID SPECIES-RICHNESS; AMPHIBIAN DECLINES; POTENTIAL CHANGES; RANDOM FORESTS;
CHANGE IMPACTS; RANGE SHIFTS; PATTERNS; MODELS; DISTRIBUTIONS;
BIODIVERSITY
AB Climate change is predicted to be one of the greatest drivers of ecological change in the coming century. Increases in temperature over the last century have clearly been linked to shifts in species distributions. Given the magnitude of projected future climatic changes, we can expect even larger range shifts in the coming century. These changes will, in turn, alter ecological communities and the functioning of ecosystems. Despite the seriousness of predicted climate change, the uncertainty in climate-change projections makes it difficult for conservation managers and planners to proactively respond to climate stresses. To address one aspect of this uncertainty, we identified predictions of faunal change for which a high level of consensus was exhibited by different climate models. Specifically, we assessed the potential effects of 30 coupled atmosphere-ocean general circulation model (AOGCM) future-climate simulations on the geographic ranges of 2954 species of birds, mammals, and amphibians in the Western Hemisphere. Eighty percent of the climate projections based on a relatively low greenhouse-gas emissions scenario result in the local loss of at least 10% of the vertebrate fauna over much of North and South America. The largest changes in fauna are predicted for the tundra, Central America, and the Andes Mountains where, assuming no dispersal constraints, specific areas are likely to experience over 90% turnover, so that faunal distributions in the future will bear little resemblance to those of today.
C1 [Lawler, Joshua J.; Blaustein, Andrew R.] Oregon State Univ, Dept Zool, Corvallis, OR 97331 USA.
[Shafer, Sarah L.] US Geol Survey, Corvallis, OR 97331 USA.
[White, Denis] US EPA, Corvallis, OR 97333 USA.
[Kareiva, Peter] Nature Conservancy, Seattle, WA 98105 USA.
[Maurer, Edwin P.] Santa Clara Univ, Dept Civil Engn, Santa Clara, CA 95053 USA.
[Bartlein, Patrick J.] Univ Oregon, Dept Geog, Eugene, OR 97403 USA.
RP Lawler, JJ (reprint author), Univ Washington, Coll Forest Resources, Seattle, WA 98195 USA.
EM jlawler@u.washington.edu
RI Maurer, Edwin/C-7190-2009; Bartlein, Patrick/E-4643-2011
OI Maurer, Edwin/0000-0001-7134-487X; Bartlein, Patrick/0000-0001-7657-5685
NR 57
TC 186
Z9 192
U1 15
U2 154
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-9658
EI 1939-9170
J9 ECOLOGY
JI Ecology
PD MAR
PY 2009
VL 90
IS 3
BP 588
EP 597
DI 10.1890/08-0823.1
PG 10
WC Ecology
SC Environmental Sciences & Ecology
GA 413EX
UT WOS:000263776800002
PM 19341131
ER
PT J
AU Keshava, C
Divi, RL
Einem, TL
Richardson, DL
Leonard, SL
Keshova, N
Poirier, MC
Weston, A
AF Keshava, Channa
Divi, Rao L.
Einem, Tracey L.
Richardson, Diana L.
Leonard, Sarah L.
Keshova, Nagalakshmi
Poirier, Miriam C.
Weston, Ainsley
TI Chlorophyllin Significantly Reduces Benzo[a]pyrene-DNA Adduct Formation
and Alters Cytochrome P450 1A1 and 1B1 expression and EROD Activity in
Normal Human Mammary Epithelial Cells
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Article
DE polycyclic aromatic hydrocarbons; microarray; chemoprevention;
chlorophyllin; NQO1; chemiluminescence immunoassay; interferon
ID POLYCYCLIC AROMATIC-HYDROCARBONS; MOLECULAR-COMPLEX FORMATION;
DNA-ADDUCTS; RAINBOW-TROUT; AFLATOXIN B-1; COVALENT BINDING;
GENE-EXPRESSION; LUNG-CANCER; MOUSE SKIN; METABOLIC-ACTIVATION
AB We hypothesized that chlorophyllin (CHLN) would reduce benzo[a]pyrene-DNA (BP-DNA) adduct levels. Using normal human mammary epithelial cells (NHMECs) exposed to 4 mu M BP for 24 hr in the presence or absence of 5 mu M CHLN, we measured BP-DNA adducts by chemiluminescence immunoassay (CIA). The protocol included the following experimental groups: BP alone, BP given simultaneously with CHLN (BP+CHLN) for 24 hr, CHLN given for 24 hr followed by BP for 24 hr (preCHLN, postBP), and CHLN given for 48 hr with BP added for the last 24 hr (preCHLN, postBP+CHLN). Incubation with CHLN decreased BPdG levels in all groups, with 87% inhibition in the preCHLN, postBP+CHLN group. To examine metabolic mechanisms, we monitored expression by Affymetrix microarray (U133A), and found BP-induced up-regulation of CYP1A1 and CYP1B1 expression, as well as upregulation of groups of interferon-inducible, inflammation and signal transduction genes. Incubation of cells with CHLN and BP in any combination decreased expression of many of these genes. Using reverse transcription real time PCR (RT-PCR) the maximal inhibition of BP-induced gene expression, >85% for CYP1A1 and >70% for CYP1B1, was observed in the preCHLN, postBP + CHLN group. To explore the relationship between transcription and enzyme activity, the ethoxyresorufin-O-deethylase (EROD) assay was used to measure the combined CYP1A1 and CYP1B1 activities. BP exposure caused the EROD levels to double, when compared with the unexposed controls, The CHLN-exposed groups all showed EROD levels similar to the unexposed controls. Therefore, the addition of CHLN to BP-exposed cells reduced BPdG formation and CYP1A1 and CYP1B1 expression, but EROD activity was not significantly reduced. Environ. Mal. Mutagen. 50:134-144, 2009. Published 2009 Wiley-Liss, Inc.(+)
C1 [Divi, Rao L.; Einem, Tracey L.; Leonard, Sarah L.; Poirier, Miriam C.] NCI, Carcinogen DNA Interact Sect, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
[Keshava, Channa; Richardson, Diana L.; Weston, Ainsley] NIOSH, Mol Carcinogenesis Team, Toxicol & Mol Biol Branch, Hlth Effects Lab Div,Ctr Dis Control & Prevent, Morgantown, WV USA.
[Keshava, Channa; Keshova, Nagalakshmi] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
[Weston, Ainsley] NIOSH, Div Resp Dis Studies, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
RP Poirier, MC (reprint author), NCI, Carcinogen DNA Interact Sect, Ctr Canc Res, NIH, Bldg 37,Rm 4032,37 Convent Dr,MSC-4255, Bethesda, MD 20892 USA.
EM poirierm@exchange.nih.gov
FU US Centers, for Disease Control (CDC); National Institute for
Occupational Safety and Health (NIOSH); US National Institutes of Health
(NIH) National Cancer Institute (NCI) Center for Cancer Research
FX Grant sponsors: Intramural Research Programs of the US Centers, for
Disease Control (CDC), National Institute for Occupational Safety and
Health (NIOSH), US National Institutes of Health (NIH) National Cancer
Institute (NCI) Center for Cancer Research.
NR 58
TC 12
Z9 12
U1 0
U2 9
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0893-6692
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD MAR
PY 2009
VL 50
IS 2
BP 134
EP 144
DI 10.1002/em.20449
PG 11
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA 408SS
UT WOS:000263455900010
PM 19152381
ER
PT J
AU Sidle, W
AF Sidle, William
TI Vulnerability of headwater catchment resources to incidences of Pb-210
excess and Cs-137 radionuclide fallout
SO ENVIRONMENTAL GEOLOGY
LA English
DT Article; Proceedings Paper
CT International Conference on Environmental - Survival and Sustainability
(ESS 2007)
CY FEB 19-24, 2007
CL Lefkosa, CYPRUS
DE Radioactivity; Water Tracing; Isotope Geochemistry
ID OUTDOOR AIR; WATER; SOILS; BE-7; FLOW; ACCUMULATION; SEDIMENTS; MAINE;
RADON; SIZE
AB Recent identification of elevated excess Pb-210 (a parts per thousand currency sign302.6 mBq L-1) and Cs-137 (a parts per thousand currency sign111.3 mBq L-1) activity in drinking water wells up to 20 m depth indicates some transport of airborne radionuclide fallout beyond soils in the Shaker Village catchment, Maine. Estimated airborne mass loading Pb-210(ex) fluxes of about 0.9 mBq m(-3), canvass this headwater catchment and may be sufficient to pose risks to unprotected shallow wells. Inventories of Pb-210(ex) and Cs-137 in pond sediments indicate maximum median activities of 943 mBq g(-1) and 40.0 mBq g(-1), respectively. Calculated Pb-210(ex) fluxes in the catchment soils range from 0.62-0.78 Bq cm(-2) year(-1) and yield a mean residence time of near 140 years. Measured Cs-137 activity up to 51.1 mBq g(-1) occurs in sediments at least to 5 m depth. Assumed particle transport in groundwater with apparent Kr-85 ages less than 5 years BP (2005) may explain the correlation between these particle-reactive radionuclides and elevated activity in some drinking water wells.
C1 US EPA, Cincinnati, OH 45268 USA.
RP Sidle, W (reprint author), US EPA, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM sidle.william@epa.gov
NR 46
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0943-0105
J9 ENVIRON GEOL
JI Environ. Geol.
PD MAR
PY 2009
VL 57
IS 2
SI SI
BP 377
EP 388
DI 10.1007/s00254-008-1306-0
PG 12
WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources
SC Environmental Sciences & Ecology; Geology; Water Resources
GA 407KI
UT WOS:000263361600015
ER
PT J
AU Mo, JY
Xia, YJ
Ning, ZX
Wade, TJ
Mumford, JL
AF Mo, Jinyao
Xia, Yajuan
Ning, Zhixiong
Wade, Timothy J.
Mumford, Judy L.
TI Elevated Human Telomerase Reverse Transcriptase Gene Expression in Blood
Cells Associated with Chronic Arsenic Exposure in Inner Mongolia, China
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE arsenic; blood; drinking water; gene expression; hTERT; humans; mRNA;
nail; telomerase; skin hyperkeratosis
ID JUN NH2-TERMINAL KINASE; HUMAN KERATINOCYTES; GENOMIC STABILITY;
DRINKING-WATER; HUMAN NAILS; DNA-REPAIR; CANCER; HTERT; STRESS; SKIN
AB BACKGROUND: Arsenic exposure is associated with human cancer. Telomerase-containing human telomerase reverse transcriptase (hTERT) can extend telomeres of chromosomes, delay senescence, and promote cell proliferation leading to tumorigenesis.
OBJECTIVE: The goal of this study was to investigate the effects of As on hTERT mRNA expression in humans and in vitro.
METHOD: A total of 324 Inner Mongolia residents who have been exposed to As via drinking water participated in this study. Water and toenail samples were collected and analyzed for As. Blood samples were quantified for hTERT mRNA expression using real-time polymerase chain reaction. The hTERT mRNA levels were linked to water and nail As concentrations and skin hyperkeratosis. Human epidermal keratinocytes were treated with arsenite to assess effects on cell viability and hTERT expression in vitro.
RESULTS: hTERT mRNA expression levels were significantly associated with As concentrations of water (p < 0.0001) and nails (p = 0.002) and also associated with severity of skin hyperkeratosis (p < 0.05), adjusting for age, sex, smoking, and pesticide use. Females showed a higher slope than males (females: 0.126, p = 0.0005; males: 0.079, p = 0.017). In addition to water and nail As concentrations, age (p < 0.0001) and pesticide use (p = 0.025) also showed significant associations with h TERT expression. The h TERT expression levels decreased with age. Tobacco smoking did not affect hTERT expression (p = 0.13). hTERT expression was significantly correlated with OGG1 and ERCC1 expression. The in vitro results also showed a dose-response relationship between arsenite concentrations and hTERT expression and reached the peak at 1 PM.
CONCLUSIONS: h TERT expression was associated with As exposure in vivo and in vitro. The increased hTERT expression may be a cellular response to genomic insults by As and may also indicate that As may function as a tumor promoter in carcinogenesis in humans.
C1 [Wade, Timothy J.; Mumford, Judy L.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Mo, Jinyao] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA.
[Xia, Yajuan] Inner Mongolia Ctr Endem Dis Control & Res, Hohhot, Inner Mongolia, Peoples R China.
[Ning, Zhixiong] BA Men Antiepidem Stn, Lin He, Inner Mongolia, Peoples R China.
RP Mumford, JL (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, MD 58C, Res Triangle Pk, NC 27711 USA.
EM mumford.judy@epa.gov
NR 57
TC 10
Z9 10
U1 0
U2 6
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAR
PY 2009
VL 117
IS 3
BP 354
EP 360
DI 10.1289/ehp.11532
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 415KV
UT WOS:000263933600021
PM 19337508
ER
PT J
AU Martin, MT
Judson, RS
Reif, DM
Kavlock, RJ
Dix, DJ
AF Martin, Matthew T.
Judson, Richard S.
Reif, David M.
Kavlock, Robert J.
Dix, David J.
TI Profiling Chemicals Based on Chronic Toxicity Results from the US EPA
ToxRef Database
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE cancer; chronic toxicity; pesticides; relational database; toxicity
profile
AB BACKGROUND: Thirty years of pesticide registration toxicity data have been historically stored as hardcopy and scanned documents by the U.S. Environmental Protection Agency (EPA). A significant portion of these data have now been processed into standardized and structured toxicity data within the EPA's Toxicity Reference Database (ToxRefDB), including chronic, cancer, developmental, and reproductive studies from laboratory animals. These data are now accessible and mineable within ToxRefDB and are serving as a primary source of validation for U.S. EPA's ToxCast research program in predictive toxicology.
OBJECTIVES: We profiled in vivo toxicities across 310 chemicals as a model application of ToxRefDB, meeting the need for detailed anchoring end points for development of ToxCast predictive signatures.
METHODS: Using query and structured data-mining approaches, we generated toxicity profiles from ToxRefDB based on long-term rodent bioassays. These chronic/cancer data were analyzed for suitability as anchoring end points based on incidence, target organ, severity, potency, and significance.
RESULTS: Under conditions of the bioassays, we observed pathologies for 273 of 310 chemicals' with greater preponderance (> 90%) occurring in the liver, kidney, thyroid, lung, testis, and spleen. We observed proliferative lesions for 225 chemicals, and 167 chemicals caused progression to cancer-related pathologies.
CONCLUSIONS: Based on incidence, severity, and potency, we selected 26 primarily tissue-specific pathology end points to uniformly classify the 310 chemicals. The resulting toxicity profile classifications demonstrate the utility of structuring legacy toxicity information and facilitating the computation of these data within ToxRefDB for ToxCast and other applications.
C1 [Martin, Matthew T.; Judson, Richard S.; Reif, David M.; Kavlock, Robert J.; Dix, David J.] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Martin, MT (reprint author), US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, MD D343-03,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Martin.Matt@epa.gov
RI Martin, Matthew/A-1982-2013;
OI Martin, Matthew/0000-0002-8096-9908; Judson,
Richard/0000-0002-2348-9633; Reif, David/0000-0001-7815-6767
FU U.S. EPA
FX The U.S. EPA, through its Office of Research and Development funded and
managed the research described here. It has been subjected to agency
review and approved for publication.
NR 18
TC 93
Z9 93
U1 2
U2 14
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAR
PY 2009
VL 117
IS 3
BP 392
EP 399
DI 10.1289/ehp.0800074
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 415KV
UT WOS:000263933600027
PM 19337514
ER
PT J
AU Li, JJ
Ghio, AJ
Cho, SH
Brinckerhoff, CE
Simon, SA
Liedtke, W
AF Li, Jinju
Ghio, Andrew J.
Cho, Seung-Hyun
Brinckerhoff, Constance E.
Simon, Sidney A.
Liedtke, Wolfgang
TI Diesel Exhaust Particles Activate the Matrix-Metalloproteinase-1 Gene in
Human Bronchial Epithelia in a beta-Arrestin-Dependent Manner via
Activation of RAS
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE beta-arrestin; bronchial epithelia; diesel particles; MAP kinase; MMP-1;
MMP-1 promoter polymorphism; urban smog
ID SINGLE NUCLEOTIDE POLYMORPHISM; BREAST-CANCER CELLS; MATRIX
METALLOPROTEINASE-1; MMP-1 PROMOTER; CIGARETTE-SMOKE; PROTEIN-KINASE;
AIR-POLLUTION; GROWTH-FACTOR; UP-REGULATION; LUNG-CANCER
AB BACKGROUND: Diesel exhaust particles (DEPs) are globally relevant air pollutants that exert a detrimental human health impact. However, mechanisms of damage by DEP exposure to human respiratory health and human susceptibility factors are only partially known. Matrix metalloproteinase-1 (MMP-1) has been implied as an (etio)pathogenic factor in human lung and airway diseases such as emphysema, chronic obstructive pulmonary disease, chronic asthma, tuberculosis, and bronchial carcinoma and has been reported to be regulated by DEPs.
OBJECTIVE: We elucidated the molecular mechanisms of DEPs' up-regulation of MMP-1.
METHODS/RESULTS: Using permanent and primary human bronchial epithelial (HBE) cells at air-liquid interface, we show that DEPs activate the human MMP-1 gene via RAS and subsequent activation of RAF-MEK-ERK1/2 mitogen-activated protein kinase signaling, which can be scaffolded by beta-arrestins. Short interfering RNA mediated beta-arrestin1/2 knockout eliminated formation, subsequent nuclear trafficking of phosphorylated ERK1/2, and resulting MMP-1 transcriptional activation. Transcriptional regulation of the human MMP-1 promoter was strongly influenced by the presence of the -1607GG polymorphism, present in 60-80% of humans, which led to striking up-regulation of MMP-1 transcriptional activation.
CONCLUSION: Our results confirm up-regulation of MMP-1 in response to DEPs in HBE and provide new mechanistic insight into how these epithelia, the first line of protection against environmental insults, up-regulate MMP-1 in response to DEP inhalation. These mechanisms include a role for the human -1607GG polymorphism as a susceptibility factor for an accentuated response, which critically depends on the ability of beta-arrestin 1/2 to generate scaffolding and nuclear trafficking of phosphorylated ERK1/2.
C1 [Li, Jinju; Simon, Sidney A.; Liedtke, Wolfgang] Duke Univ, Dept Neurobiol, Durham, NC 27710 USA.
[Ghio, Andrew J.] US EPA, Chapel Hill, NC USA.
[Cho, Seung-Hyun] US EPA, Res Triangle Pk, NC 27711 USA.
[Brinckerhoff, Constance E.] Dartmouth Hitchcock Med Ctr, Norris Cotton Canc Ctr, Dept Med, Lebanon, NH 03766 USA.
[Brinckerhoff, Constance E.] Dartmouth Hitchcock Med Ctr, Norris Cotton Canc Ctr, Dept Biochem, Lebanon, NH 03766 USA.
[Simon, Sidney A.] Duke Univ, Ctr Neuroengn, Durham, NC 27710 USA.
[Liedtke, Wolfgang] Duke Univ, Dept Med, Div Neurol, Durham, NC 27710 USA.
RP Liedtke, W (reprint author), Duke Univ, Dept Med, Div Neurol, Box 2900, Durham, NC 27710 USA.
EM wolfgang@neuro.duke.edu
RI Liedtke, Wolfgang/G-4633-2011
FU Duke University; Klingenstein Fellowship Award (Robert Ebert Clinical
Scholar); Philip Morris USA, Inc; Philip Morris International; National
Institutes of Health [AR-26599, CA-77267]; U.S. Environmental Protection
Agency (EPA)
FX S.A.S, W.L., and J.L. received funding from Philip Morris USA and Philip
Morris International. The other authors declare they have no competing
financial interests.
NR 68
TC 20
Z9 24
U1 0
U2 8
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAR
PY 2009
VL 117
IS 3
BP 400
EP 409
DI 10.1289/ehp.0800311
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 415KV
UT WOS:000263933600028
PM 19337515
ER
PT J
AU Yang, D
Kim, KH
Phimister, A
Bachstetter, AD
Ward, TR
Stackman, RW
Mervis, RF
Wisniewski, AB
Klein, SL
Kodavanti, PRS
Anderson, KA
Wayman, G
Pessah, IN
Lein, PJ
AF Yang, Dongren
Kim, Kyung Ho
Phimister, Andrew
Bachstetter, Adam D.
Ward, Thomas R.
Stackman, Robert W.
Mervis, Ronald F.
Wisniewski, Amy B.
Klein, Sabra L.
Kodavanti, Prasada Rao S.
Anderson, Kim A.
Wayman, Gary
Pessah, Isaac N.
Lein, Pamela J.
TI Developmental Exposure to Polychlorinated Biphenyls Interferes with
Experience-Dependent Dendritic Plasticity and Ryanodine Receptor
Expression in Weanling Rats
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE dendrite; neurodevelopmental disorders; developmental neurotoxicity;
PCBs; plasticity; ryanodine receptor
ID CALCIUM-RELEASE CHANNEL; ADULT-RATS; THYROID-HORMONE; NEURODEVELOPMENTAL
DISORDERS; ENVIRONMENTAL CHEMICALS; SKELETAL-MUSCLE; GENE-EXPRESSION;
MAMMALIAN BRAIN; CEREBRAL-CORTEX; ADIPOSE-TISSUE
AB BACKGROUND: Neurodevelopmental disorders are associated with altered patterns of neuronal connectivity. A critical determinant of neuronal connectivity is the dendritic morphology of individual neurons, which is shaped by experience. The identification of environmental exposures that interfere with dendritic growth and plasticity may, therefore, provide insight into environmental risk factors for neurodevelopmental disorders.
OBJECTIVE: We tested the hypothesis that polychlorinated biphenyls (PCBs) alter dendritic growth and/or plasticity by promoting the activity of ryanodine receptors (RyRs).
METHODS AND RESULTS: The Morris water maze was used to induce experience-dependent neural plasticity in weanling rats exposed to either vehicle or Aroclor 1254 (A1254) in the maternal diet throughout gestation and lactation. Developmental A1254 exposure promoted dendritic growth in cerebellar Purkinje cells and neocortical pyramidal neurons among untrained animals but attenuated or reversed experience-dependent dendritic growth among maze-trained littermates. These structural changes coincided with subtle deficits in spatial learning and memory, increased [H-3]-ryanodine binding sites and RyR expression in the cerebellum of untrained animals, and inhibition of training-induced RyR upregulation. A congener with potent RyR activity, PCB95, but not a congener with negligible RyR activity, PCB66, promoted dendritic growth in primary cortical neuron cultures and this effect was blocked by pharmacologic antagonism of RyR activity.
CONCLUSIONS: Developmental exposure to PCBs interferes with normal patterns of dendritic growth and plasticity, and these effects may be linked to changes in RyR expression and function. These findings identify PCBs as candidate environmental risk factors for neurodevelopmental disorders, especially in children with heritable deficits in calcium signaling.
C1 [Yang, Dongren; Lein, Pamela J.] Oregon Hlth & Sci Univ, Ctr Res Occupat & Environm Toxicol, Portland, OR 97201 USA.
[Lein, Pamela J.] Univ Calif Davis, Dept Mol Biosci, Ctr Childrens Environm Hlth, Davis, CA 95616 USA.
[Bachstetter, Adam D.; Mervis, Ronald F.] Univ S Florida, Coll Med, Neurostruct Res Labs, Tampa, FL USA.
[Bachstetter, Adam D.; Mervis, Ronald F.] Univ S Florida, Coll Med, Ctr Aging & Brain Repair, Tampa, FL USA.
[Ward, Thomas R.; Kodavanti, Prasada Rao S.] US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Stackman, Robert W.] Florida Atlantic Univ, Dept Psychol, Boca Raton, FL 33431 USA.
[Wisniewski, Amy B.] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK 73190 USA.
[Klein, Sabra L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA.
[Anderson, Kim A.] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA.
[Wayman, Gary] Washington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA.
[Lein, Pamela J.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD USA.
RP Lein, PJ (reprint author), Univ Calif Davis, Dept Mol Biosci, Ctr Childrens Environm Hlth, 1120 Haring Hall,1 Shields Ave, Davis, CA 95616 USA.
EM pjlein@ucdavis.edu
OI Stackman Jr, Robert/0000-0002-5950-046X
FU National Institutes of Health [HD40936, NS046649, 1PO1ES11269,
GM041292]; UC Davis M.I.N.D. Institute
FX Support was provided by the National Institutes of Health (HD40936 and
NS046649 to P.J.L., 1PO1ES11269 to I.N.P. and GM041292 to G.A.W.),
Autism Speaks (I.N.P.), and the UC Davis M.I.N.D. Institute.
NR 83
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U1 2
U2 7
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAR
PY 2009
VL 117
IS 3
BP 426
EP 435
DI 10.1289/ehp.11771
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 415KV
UT WOS:000263933600031
PM 19337518
ER
PT J
AU Jackson, LE
Paulsen, SG
AF Jackson, Laura E.
Paulsen, Steven G.
TI Special issue: The Eighth Symposium of the Environmental Monitoring and
Assessment Program (EMAP) - research and partnerships for accountability
Preface
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Editorial Material
C1 [Jackson, Laura E.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC USA.
[Paulsen, Steven G.] US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Corvallis, OR USA.
RP Jackson, LE (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC USA.
EM jackson.laura@epa.gov
NR 12
TC 0
Z9 0
U1 1
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD MAR
PY 2009
VL 150
IS 1-4
BP 1
EP 2
DI 10.1007/s10661-008-0667-x
PG 2
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 404NM
UT WOS:000263159900001
PM 19082750
ER
PT J
AU Stahl, LL
Snyder, BD
Olsen, AR
Pitt, JL
AF Stahl, Leanne L.
Snyder, Blaine D.
Olsen, Anthony R.
Pitt, Jennifer L.
TI Contaminants in fish tissue from US lakes and reservoirs: a national
probabilistic study
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
CT 8th Symposium of the Environmental Monitoring and Assessment Program
CY APR 10-11, 2007
CL Washington, DC
DE Fish tissue; Contaminants; Lakes; Probabilistic survey; Mercury; PCB;
Dioxin; Furan; DDT; Chlordane
ID RAINBOW-TROUT; FOOD-WEB; MERCURY; PCB;
2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN; ACCUMULATION; PATTERNS; KINETICS
AB An unequal probability design was used to develop national estimates for 268 persistent, bioaccumulative, and toxic chemicals in fish tissue from lakes and reservoirs of the conterminous United States (excluding the Laurentian Great Lakes and Great Salt Lake). Predator (fillet) and bottom-dweller (whole body) composites were collected from 500 lakes selected randomly from the target population of 147,343 lakes in the lower 48 states. Each of these composite types comprised nationally representative samples whose results were extrapolated to the sampled population of an estimated 76,559 lakes for predators and 46,190 lakes for bottom dwellers. Mercury and PCBs were detected in all fish samples. Dioxins and furans were detected in 81% and 99% of predator and bottom-dweller samples, respectively. Cumulative frequency distributions showed that mercury concentrations exceeded the EPA 300 ppb mercury fish tissue criterion at nearly half of the lakes in the sampled population. Total PCB concentrations exceeded a 12 ppb human health risk-based consumption limit at nearly 17% of lakes, and dioxins and furans exceeded a 0.15 ppt (toxic equivalent or TEQ) risk-based threshold at nearly 8% of lakes in the sampled population. In contrast, 43 target chemicals were not detected in any samples. No detections were reported for nine organophosphate pesticides, one PCB congener, 16 polycyclic aromatic hydrocarbons, or 17 other semivolatile organic chemicals.
C1 [Stahl, Leanne L.] US EPA, OW Off Sci & Technol, Washington, DC 20460 USA.
[Snyder, Blaine D.; Pitt, Jennifer L.] Tetra Tech Inc, Ctr Ecol Sci, Owings Mills, MD 21117 USA.
[Olsen, Anthony R.] ORD Natl Hlth & Environm Effects Lab, Western Ecol Div, Corvallis, OR 97333 USA.
RP Stahl, LL (reprint author), US EPA, OW Off Sci & Technol, 1200 Penn Ave,NW MC 4305, Washington, DC 20460 USA.
EM stahl.leanne@epa.gov
NR 57
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U1 3
U2 34
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD MAR
PY 2009
VL 150
IS 1-4
BP 3
EP 19
DI 10.1007/s10661-008-0669-8
PG 17
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 404NM
UT WOS:000263159900002
PM 19067201
ER
PT J
AU Nestlerode, JA
Engle, VD
Bourgeois, P
Heitmuller, PT
Macauley, JM
Allen, YC
AF Nestlerode, Janet A.
Engle, Virginia D.
Bourgeois, Pete
Heitmuller, Paul T.
Macauley, John M.
Allen, Yvonne C.
TI An integrated approach to assess broad-scale condition of coastal
wetlands - the Gulf of Mexico Coastal Wetlands pilot survey
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
CT 8th Symposium of the Environmental Monitoring and Assessment Program
CY APR 10-11, 2007
CL Washington, DC
DE Coastal wetlands; Condition assessment; Gulf of Mexico; Multi-scale
assessment approach; Regional pilot study
ID HYDROLOGIC ALTERATION; NATURAL-RESOURCES; USA
AB The Environmental Protection Agency (EPA) and U.S. Geological Survey (USGS) initiated a two-year regional pilot survey in 2007 to develop, test, and validate tools and approaches to assess the condition of northern Gulf of Mexico (GOM) coastal wetlands. Sampling sites were selected from estuarine and palustrine wetland areas with herbaceous, forested, and shrub/scrub habitats delineated by the US Fish and Wildlife Service National Wetlands Inventory Status and Trends (NWI S&T) program and contained within northern GOM coastal watersheds. A multi-level, stepwise, iterative survey approach is being applied to multiple wetland classes at 100 probabilistically-selected coastal wetlands sites. Tier 1 provides information at the landscape scale about habitat inventory, land use, and environmental stressors associated with the watershed in which each wetland site is located. Tier 2, a rapid assessment conducted through a combination of office and field work, is based on best professional judgment and on-site evidence. Tier 3, an intensive site assessment, involves on-site collection of vegetation, water, and sediment samples to establish an integrated understanding of current wetland condition and validate methods and findings from Tiers 1 and 2. The results from this survey, along with other similar regional pilots from the Mid-Atlantic, West Coast, and Great Lakes Regions will contribute to a design and implementation approach for the National Wetlands Condition Assessment to be conducted by EPA's Office of Water in 2011.
C1 [Nestlerode, Janet A.; Engle, Virginia D.; Macauley, John M.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
[Bourgeois, Pete; Heitmuller, Paul T.; Allen, Yvonne C.] US Geol Survey, Natl Wetlands Res Ctr, Gulf Breeze Project Off, Gulf Breeze, FL USA.
RP Nestlerode, JA (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM nestlerode.janet@epa.gov
NR 46
TC 9
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U1 2
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD MAR
PY 2009
VL 150
IS 1-4
BP 21
EP 29
DI 10.1007/s10661-008-0668-9
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 404NM
UT WOS:000263159900003
PM 19037735
ER
PT J
AU Bradley, P
Fisher, WS
Bell, H
Davis, W
Chan, V
LoBue, C
Wiltse, W
AF Bradley, Patricia
Fisher, William S.
Bell, Heidi
Davis, Wayne
Chan, Valerie
LoBue, Charles
Wiltse, Wendy
TI Development and implementation of coral reef biocriteria in US
jurisdictions
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article; Proceedings Paper
CT 8th Symposium of the Environmental Monitoring and Assessment Program
CY APR 10-11, 2007
CL Washington, DC
DE Bioassessment; Biocriteria; Clean Water Act; Coral reefs; Coral reef
ecosystems; Rapid bioassessment protocol; RBP; Stony corals; US EPA
ID COLONY SURFACE-AREA; INTEGRITY; FUTURE
AB Coral reefs worldwide are declining at an alarming rate and are under continuous threat from both natural and anthropogenic environmental stressors. Warmer sea temperatures attributed to global climate change and numerous human activities at local scales place these valuable ecosystems at risk. Reefs provide numerous services, including shoreline protection, fishing, tourism and biological diversity, which are lost through physical damage, overfishing, and pollution. Pollution can be controlled under provisions of the Clean Water Act, but these options have not been fully employed to protect coral reefs. No U.S. jurisdiction has implemented coral reef biocriteria, which are narrative or quantitative water quality standards based on the condition of a biological resource or assemblage. The President's Ocean Action Plan directs the U.S. Environmental Protection Agency (EPA) to develop biological assessment methods and biological criteria for evaluating and maintaining the health of coral reef ecosystems. EPA has formed the Coral Reef Biocriteria Working Group (CRBWG) to foster development of coral reef biocriteria through focused research, evaluation and communication among Agency partners and U.S. jurisdictions. Ongoing CRBWG activities include development and evaluation of a rapid bioassessment protocol for application in biocriteria programs; development of a survey design and monitoring strategy for the U.S. Virgin Islands; comprehensive reviews of biocriteria approaches proposed by states and territories; and assembly of data from a variety of monitoring programs for additional metrics. Guidance documents are being prepared to assist U.S. jurisdictions in reaching protective and defensible biocriteria.
C1 [Bradley, Patricia] US EPA, Off Res & Dev, FKNMS, Key West, FL 33040 USA.
[Bradley, Patricia] US EPA, Atlantic Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Key West, FL 33040 USA.
[Fisher, William S.] US EPA, Gulf Ecol Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Gulf Breeze, FL USA.
[Bell, Heidi] US EPA, Off Sci & Technol, Off Water, Washington, DC 20460 USA.
[Davis, Wayne] US EPA, Environm Anal Div, Off Environm Informat, Ft George G Meade, MD USA.
[Chan, Valerie] US EPA, Off Sci Policy, Off Res & Dev, Washington, DC 20460 USA.
[LoBue, Charles] US EPA, Div Environm Planning & Protect, New York, NY USA.
[Wiltse, Wendy] US EPA, Honolulu, HI USA.
RP Bradley, P (reprint author), US EPA, Off Res & Dev, FKNMS, 33 E Quay Rd, Key West, FL 33040 USA.
EM bradley.patricia@epa.gov
NR 45
TC 4
Z9 5
U1 0
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD MAR
PY 2009
VL 150
IS 1-4
BP 43
EP 51
DI 10.1007/s10661-008-0670-2
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 404NM
UT WOS:000263159900005
PM 19052888
ER
PT J
AU Miller, MA
Colby, ACC
Kanehl, PD
Blocksom, K
AF Miller, Michael A.
Colby, Alison C. C.
Kanehl, Paul D.
Blocksom, Karen
TI Assessment of wadeable stream resources in the driftless area ecoregion
in Western Wisconsin using a probabilistic sampling design
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
CT 8th Symposium of the Environmental Monitoring and Assessment Program
CY APR 10-11, 2007
CL Washington, DC
DE Stream assessment; Driftless ecoregion; Probability survey design;
Biological assessment
AB The Wisconsin Department of Natural Resources (WDNR), with support from the U.S. EPA, conducted an assessment of wadeable streams in the Driftless Area ecoregion in western Wisconsin using a probabilistic sampling design. This ecoregion encompasses 20% of Wisconsin's land area and contains 8,800 miles of perennial streams. Randomly-selected stream sites (n = 60) equally distributed among stream orders 1-4 were sampled. Watershed land use, riparian and in-stream habitat, water chemistry, macroinvertebrate, and fish assemblage data were collected at each true random site and an associated "modified-random" site on each stream that was accessed via a road crossing nearest to the true random site. Targeted least-disturbed reference sites (n = 22) were also sampled to develop reference conditions for various physical, chemical, and biological measures. Cumulative distribution function plots of various measures collected at the true random sites evaluated with reference condition thresholds, indicate that high proportions of the random sites (and by inference the entire Driftless Area wadeable stream population) show some level of degradation. Study results show no statistically significant differences between the true random and modified-random sample sites for any of the nine physical habitat, 11 water chemistry, seven macroinvertebrate, or eight fish metrics analyzed. In Wisconsin's Driftless Area, 79% of wadeable stream lengths were accessible via road crossings. While further evaluation of the statistical rigor of using a modified-random sampling design is warranted, sampling randomly-selected stream sites accessed via the nearest road crossing may provide a more economical way to apply probabilistic sampling in stream monitoring programs.
C1 [Miller, Michael A.; Colby, Alison C. C.] Bur Fisheries Management, Wisconsin Dept Nat Resources, Madison, WI 53703 USA.
[Kanehl, Paul D.] Bur Integrated Sci Serv, Wisconsin Dept Nat Resources, Madison, WI USA.
[Blocksom, Karen] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
RP Miller, MA (reprint author), Bur Fisheries Management, Wisconsin Dept Nat Resources, 101 S Webster St, Madison, WI 53703 USA.
EM Michaela.miller@wisconsin.gov
NR 21
TC 1
Z9 1
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD MAR
PY 2009
VL 150
IS 1-4
BP 75
EP 89
DI 10.1007/s10661-008-0679-6
PG 15
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 404NM
UT WOS:000263159900008
PM 19058017
ER
PT J
AU Olsen, AR
Snyder, BD
Stahl, LL
Pitt, JL
AF Olsen, Anthony R.
Snyder, Blaine D.
Stahl, Leanne L.
Pitt, Jennifer L.
TI Survey design for lakes and reservoirs in the United States to assess
contaminants in fish tissue
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
CT 8th Symposium of the Environmental Monitoring and Assessment Program
CY APR 10-11, 2007
CL Washington, DC
DE Fish tissue; Contaminants; Lakes; Reservoirs; Probability survey design;
PBTs
ID RESOURCES
AB The National Lake Fish Tissue Study (NLFTS) was the first survey of fish contamination in lakes and reservoirs in the 48 conterminous states based on a probability survey design. This study included the largest set (268) of persistent, bioaccumulative, and toxic (PBT) chemicals ever studied in predator and bottom-dwelling fish species. The U.S. Environmental Protection Agency (USEPA) implemented the study in cooperation with states, tribal nations, and other federal agencies, with field collection occurring at 500 lakes and reservoirs over a four-year period (2000-2003). The sampled lakes and reservoirs were selected using a spatially balanced unequal probability survey design from 270,761 lake objects in USEPA's River Reach File Version 3 (RF3). The survey design selected 900 lake objects, with a reserve sample of 900, equally distributed across six lake area categories. A total of 1,001 lake objects were evaluated to identify 500 lake objects that met the study's definition of a lake and could be accessed for sampling. Based on the 1,001 evaluated lakes, it was estimated that a target population of 147,343 (+/-7% with 95% confidence) lakes and reservoirs met the NLFTS definition of a lake. Of the estimated 147,343 target lakes, 47% were estimated not to be sampleable either due to landowner access denial (35%) or due to physical barriers (12%). It was estimated that a sampled population of 78,664 (+/-12% with 95% confidence) lakes met the NLFTS lake definition, had either predator or bottom-dwelling fish present, and could be sampled.
C1 [Olsen, Anthony R.] US EPA, ORD Natl Hlth & Environm Effects Lab, Western Ecol Div, Corvallis, OR 97333 USA.
[Snyder, Blaine D.; Pitt, Jennifer L.] Tetra Tech Inc, Ctr Ecol Sci, Baltimore, MD 21117 USA.
[Stahl, Leanne L.] US EPA, OW Off Sci & Technol, Washington, DC 20460 USA.
RP Olsen, AR (reprint author), US EPA, ORD Natl Hlth & Environm Effects Lab, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA.
EM olsen.tony@epa.gov
NR 28
TC 12
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U1 0
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD MAR
PY 2009
VL 150
IS 1-4
BP 91
EP 100
DI 10.1007/s10661-008-0685-8
PG 10
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 404NM
UT WOS:000263159900009
PM 19052884
ER
PT J
AU DiDonato, GT
DiDonato, EM
Smith, LM
Harwell, LC
Summers, JK
AF DiDonato, Guy T.
DiDonato, Eva M.
Smith, Lisa M.
Harwell, Linda C.
Summers, J. Kevin
TI Assessing coastal waters of American Samoa: territory-wide water quality
data provide a critical "big-picture" view for this tropical archipelago
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
CT 8th Symposium of the Environmental Monitoring and Assessment Program
CY APR 10-11, 2007
CL Washington, DC
DE American Samoa; Coastal water quality; Probabilistic design; South
Pacific
ID CORAL-REEFS; COMMUNITIES; ESTUARIES; FLORIDA
AB The coastal waters of American Samoa's five high islands (Tutuila, Aunu'u, Ofu, Olosega, and Ta'u) were surveyed in 2004 using a probabilistic design. Water quality data were collected from the near-shore coastal habitat, defined as all near-shore coastal waters including embayments, extending out to 1/4 mile off-shore. Hydrography and water column samples were collected, and water quality data were compared to the Territorial water quality standards for pH, dissolved oxygen (DO), Enterococcus, chlorophyll a, water clarity, total nitrogen, and total phosphorus. All station measurements for pH, DO, and Enterococcus satisfied the local water quality standards, although some fraction of the Territory could not be assessed for either DO or Enterococcus. With respect to chlorophyll a, 66 +/- 18% of Territory coastal waters complied with the standard, while 34 +/- 18% failed to comply with the standard. For water clarity, 54 +/- 18% of the Territorial waters complied with the standard while 42 +/- 7% failed to comply. Territorial waters satisfied the standards for total nitrogen and phosphorus 72 +/- 17% and 92 +/- 10%, respectively. These data provide the first "big-picture" view of water quality in the near shore region around the high islands of American Samoa. While the picture is encouraging, these data suggest emerging water quality concerns.
C1 [DiDonato, Guy T.] Amer Samoa Environm Protect Agcy, Pago Pago, AS 96799 USA.
[DiDonato, Eva M.] Natl Pk Amer Samoa, Pago Pago, AS 96799 USA.
[Smith, Lisa M.; Harwell, Linda C.; Summers, J. Kevin] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP DiDonato, GT (reprint author), Natl Ocean Serv, Hollings Marine Lab, Charleston, SC 29412 USA.
EM guy.didonato@noaa.gov
NR 17
TC 1
Z9 1
U1 3
U2 19
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD MAR
PY 2009
VL 150
IS 1-4
BP 157
EP 165
DI 10.1007/s10661-008-0674-y
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 404NM
UT WOS:000263159900014
PM 19082748
ER
PT J
AU Rashleigh, B
Cyterski, M
Smith, LM
Nestlerode, JA
AF Rashleigh, Brenda
Cyterski, Mike
Smith, Lisa M.
Nestlerode, Janet A.
TI Relation of fish and shellfish distributions to habitat and water
quality in the Mobile Bay estuary, USA
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
CT 8th Symposium of the Environmental Monitoring and Assessment Program
CY APR 10-11, 2007
CL Washington, DC
DE Discriminant analysis; Estuaries Fish diversity; Mobile Bay; Ordination
ID COMMUNITY
AB The Mobile Bay estuary in the northern Gulf of Mexico provides a rich habitat for many fish and shellfish, including those identified as economically and ecologically important. The National Estuary Program in Mobile Bay has focused on restoration of degraded estuarine habitat on which these species depend. To support this effort, we used statistical techniques of ordination, cluster analysis, and discriminant analysis to relate distributions of individual fish and shellfish species and species assemblages to two dozen water quality and habitat variables in a geo-referenced database. Species appeared to respond to dominant gradients of low to high salinity and upland to offshore habitat area; many of the 15 communities identified via cluster analysis showed aggregated spatial distributions that could be related to habitat characteristics. Species in the Mobile River Delta were distinct from those in other areas of the estuary. This analysis supports habitat management in the Mobile Bay estuary; however, due to mobility of organisms among sampling locations and the dynamic environmental conditions in estuaries, we conclude that the analyses presented here are most appropriate for an evaluation of the estuary as a whole.
C1 [Rashleigh, Brenda; Cyterski, Mike] US EPA, Athens, GA 30605 USA.
[Smith, Lisa M.; Nestlerode, Janet A.] US EPA, Gulf Breeze, FL USA.
RP Rashleigh, B (reprint author), US EPA, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM rashleigh.brenda@epa.gov
NR 23
TC 3
Z9 3
U1 1
U2 12
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD MAR
PY 2009
VL 150
IS 1-4
BP 181
EP 192
DI 10.1007/s10661-008-0681-z
PG 12
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 404NM
UT WOS:000263159900016
PM 19083112
ER
PT J
AU Engle, VD
Hyland, JL
Cooksey, C
AF Engle, V. D.
Hyland, Jeffrey L.
Cooksey, Cynthia
TI Effects of Hurricane Katrina on benthic macroinvertebrate communities
along the northern Gulf of Mexico coast
SO ENVIRONMENTAL MONITORING AND ASSESSMENT
LA English
DT Article
CT 8th Symposium of the Environmental Monitoring and Assessment Program
CY APR 10-11, 2007
CL Washington, DC
DE Hurricane effects; Benthos Estuarine dynamics; Salinity effects; Gulf of
Mexico
ID LAKE PONTCHARTRAIN; MULTIPLE HURRICANES; LOUISIANA; SEDIMENTS; IMPACTS;
MARINE; STRESS; ESTUARIES; RESPONSES; QUALITY
AB The effects of Hurricane Katrina on benthic fauna and habitat quality in coastal waters of Louisiana, Mississippi, and Alabama, USA, were assessed in October, 2005, 2 months after the hurricane made landfall between New Orleans, LA and Biloxi, MS. Benthic macrofaunal samples, sediment chemical concentrations, and water quality measurements from 60 sites in Lake Pontchartrain and Mississippi Sound were compared with pre-hurricane conditions from 2000-2004. Post-hurricane benthic communities had significant reductions in numbers of taxa, H' diversity, and abundance as well as shifts in composition and ranking of dominant taxa. These effects were not associated with changes in chemical contamination, organic enrichment of sediments, or hypoxia and were likely due to hurricane-related scouring and changes in salinity.
C1 [Engle, V. D.] US EPA, ORD NHEERL Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
[Hyland, Jeffrey L.; Cooksey, Cynthia] Natl Ocean Serv, Natl Ocean & Atmospher Adm, Charleston, SC 29412 USA.
RP Engle, VD (reprint author), US EPA, ORD NHEERL Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM engle.virginia@epa.gov
NR 31
TC 12
Z9 13
U1 5
U2 27
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6369
J9 ENVIRON MONIT ASSESS
JI Environ. Monit. Assess.
PD MAR
PY 2009
VL 150
IS 1-4
BP 193
EP 209
DI 10.1007/s10661-008-0677-8
PG 17
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 404NM
UT WOS:000263159900017
PM 19052887
ER
PT J
AU Meyer, DE
Curran, MA
Gonzalez, MA
AF Meyer, David E.
Curran, Mary Ann
Gonzalez, Michael A.
TI An Examination of Existing Data for the Industrial Manufacture and Use
of Nanocomponents and Their Role in the Life Cycle Impact of
Nanoproducts
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ZERO-VALENT IRON; NANOTECHNOLOGY; NANOMATERIALS; NANOPARTICLES;
EXPOSURE; RISKS; ENVIRONMENT; MANAGEMENT; PARTICLES; INVENTORY
AB This work examines the manufacture and use of nanocomponents and how they can affect the life cycle impact of resulting nanoproducts. Available data on the production of nanoproducts and nanocomponents are used to identify the major groups of nanocomponents studied in this paper: inorganic nanoparticles, carbon-based nanomaterials, and specialty/composite materials. A comparison of existing results for life cycle assessments of nanocomponents and nanoproducts is used to possibly identify trends in nanomanufacturing based on material grouping with regard to nonrenewable energy use and greenhouse gas emissions. Continuing work is needed in this area to incorporate other factors such as toxicity and resource consumption in addition to energy use and global warming potential to fully understand the role of nanomanufacturing in the life cycle of nanoproducts.
C1 [Meyer, David E.; Curran, Mary Ann; Gonzalez, Michael A.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Meyer, DE (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM meyer.david@epa.gov
OI Curran, Mary Ann/0000-0001-8565-9928
NR 43
TC 63
Z9 65
U1 2
U2 43
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAR 1
PY 2009
VL 43
IS 5
BP 1256
EP 1263
DI 10.1021/es8023258
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 412XX
UT WOS:000263758600008
PM 19350888
ER
PT J
AU Hubbard, H
Poppendieck, D
Corsi, RL
AF Hubbard, Heidi
Poppendieck, Dustin
Corsi, Richard L.
TI Chlorine Dioxide Reactions with Indoor Materials during Building
Disinfection: Surface Uptake
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID DECONTAMINATION; GAS
AB Chlorine dioxide received attention as a building disinfectant in the wake of Bacillus anthracis contamination of several large buildings in the fall of 2001. It is increasingly used for the disinfection of homes and other indoor environments afflicted by mold. However, little is known regarding the interaction of chlorine dioxide and indoor materials, particularly as related to the removal of chlorine dioxide from air. Such removal may be undesirable with respect to the subsequent formation of localized zones of depleted disinfectant concentrations and potential reductions in disinfection effectiveness in a building. The focus of this paper is on chlorine dioxide removal from air to each of 24 different indoor materials. Experiments were completed with materials housed in flow-through 48-L stainless steel chambers under standard conditions of 700 ppm chlorine dioxide inlet concentration, 75% relative humidity, 24 degrees C, and 0.5 h(-1) air changes. Chlorine dioxide concentration profiles, deposition velocities, and reaction probabilities are described in this paper. Deposition velocities and reaction probabilities varied over approximately 2 orders of magnitude across all materials. For most materials, deposition velocity decreased significantly over a 16-h disinfection period; that is, materials became smaller sinks for chlorine dioxide with time. Four materials (office partition, ceiling tile, medium density fiberboard, and gypsum wallboard) accounted for the most short- and long-term consumption of chlorine dioxide. Deposition velocity was observed to be a strong function of chlorine dioxide inlet concentration, suggesting the potential importance of chemical reactions on or within test materials.
C1 [Corsi, Richard L.] Univ Texas Austin, Dept Civil Architectural & Environm Engn, Austin, TX 78758 USA.
[Hubbard, Heidi] US EPA, Res Triangle Pk, NC 27711 USA.
[Poppendieck, Dustin] Humboldt State Univ, Dept Environm Resources Engn, Arcata, CA 95521 USA.
RP Corsi, RL (reprint author), Univ Texas Austin, Dept Civil Architectural & Environm Engn, 10100 Burnet Rd R7100,Bldg 133, Austin, TX 78758 USA.
EM corsi@mail.utexas.edu
NR 15
TC 9
Z9 10
U1 1
U2 14
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAR 1
PY 2009
VL 43
IS 5
BP 1329
EP 1335
DI 10.1021/es801930c
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 412XX
UT WOS:000263758600019
PM 19350899
ER
PT J
AU Bern, AM
Lowers, HA
Meeker, GP
Rosati, JA
AF Bern, Amy M.
Lowers, Heather A.
Meeker, Gregory P.
Rosati, Jacky A.
TI Method Development for Analysis of Urban Dust Using Scanning Electron
Microscopy with Energy Dispersive X-ray Spectrometry to Detect the
Possible Presence of World Trade Center Dust Constituents
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
AB The collapse of the World Trade Center Towers on September 11, 2001, sent dust and debris across much of Manhattan and in the surrounding areas. Indoor and outdoor dust samples were collected and characterized by U.S. Geological Survey (USGS) scientists using scanning electron microscopy with energy-dispersive spectrometry (SEM/EDS). From this characterization, the U.S. Environmental Protection Agency and USGS developed a particulate screening method to determine the presence of residual World Trade Center dust in the indoor environment using slag wool as a primary "signature". The method describes a procedure that includes splitting, ashing, and sieving of collected dust From one split, a 10 mg/mL dust/isopropanol suspension was prepared and 10-30 mu L aliquots of the suspension placed on an SEM substrate. Analyses were performed using SEM/EDS manual point counting for slag wool fibers. Poisson regression was used to identify some of the sources of uncertainty, which are directly related to the small number of fibers present on each sample stub. Preliminary results indicate that the procedure is promising for screening urban background dust for the presence of WTC dust Consistent sample preparation of reference materials and samples must be performed by each laboratory wishing to use this method to obtain meaningful and accurate results.
C1 [Bern, Amy M.] US EPA, Natl Enforcement Invest Ctr, Denver Fed Ctr, Denver, CO 80225 USA.
[Lowers, Heather A.; Meeker, Gregory P.] US Geol Survey, Cent Reg, Denver Fed Ctr, Denver, CO 80225 USA.
[Rosati, Jacky A.] S Environm Protect Agcy, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC USA.
RP Bern, AM (reprint author), US EPA, Natl Enforcement Invest Ctr, Denver Fed Ctr, Bldg 25,POB 25227, Denver, CO 80225 USA.
EM Bern.Amy@epa.gov
NR 24
TC 3
Z9 3
U1 0
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAR 1
PY 2009
VL 43
IS 5
BP 1449
EP 1454
DI 10.1021/es800865n
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 412XX
UT WOS:000263758600038
PM 19350918
ER
PT J
AU Song, WH
Xu, TL
Cooper, WJ
Dionysiou, DD
De La Cruz, AA
O'Shea, KE
AF Song, Weihua
Xu, Tielian
Cooper, William J.
Dionysiou, Dionysios D.
De La Cruz, Armah A.
O'Shea, Kevin E.
TI Radiolysis Studies on the Destruction of Microcystin-LR in Aqueous
Solution by Hydroxyl Radicals
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ULTRASONICALLY INDUCED DEGRADATION; PHOTOCATALYTIC OXIDATION;
PULSE-RADIOLYSIS; DRINKING-WATER; RATE CONSTANTS; CYANOBACTERIAL TOXIN;
ORGANIC-MATTER; TIO2; DETOXIFICATION; DECOMPOSITION
AB In this study, steady-state and time-resolved radiolysis methods were used to determine the primary reaction pathways and kinetic parameters for the reactions of hydroxyl radical with microcystin-LR (MC-LR). The fundamental kinetic data is critical for the accurate evaluation of hydroxyl-radical based technologies for the destruction of this problematic class of cyanotoxins. The bimolecular rate constant for the reaction of hydroxyl radical with MC-LR is 2.3 (+/- 0.1) x 10(10) M(-1)s(-1) based on time-resolved competition kinetics with SCN(-) at low conversions using pulsed radiolysis experiments. The reaction of hydroxyl radical with MC-LR can Occur via a number of competing reaction pathways, including addition to the benzene ring and diene and abstraction of aliphatic hydrogen atoms. LC-MS analyses indicate the major products from the reaction of hydroxyl radicals with MC-LR involve addition of hydroxyl radical to the benzene ring and diene moieties of the Adda side chain. Transient absorption spectroscopy monitored between 260-500 nm, following pulsed hydroxyl radical generation, indicate the formation of a transient species with absorption maxima at 270 and 310 nm. The absorption maxima and lifetime of the transient species are characteristic of hydroxycyclohexadienyl radicals resulting from the addition of hydroxyl radical to the benzene ring. The rate constant for the formation of hydroxycyclohexadienyl radical is 1.0 (+/- 0.1) x 10(10) M(-1)s(-1) accounting for similar to 40% of the primary reaction pathways. Representative rate constants and partitioning of hydroxyl radical reactions were assessed based on the reactivities of surrogate substrates and individual amino acids. Summation of the individual reactivities of hydroxyl radical at the differentreactive sites (amino acids) leads to a rate constant of 2.1 x 10(10) M(-1) s(-1) in good agreement with the rate constant determined in our studies. The relative magnitude of the rate constants for the reactions of hydroxyl radical with the individual amino acids and appropriate surrogates, suggest 60-70% reactions of hydroxyl radical occur at the benzene and diene functional groups of the Adda moiety.
C1 [Song, Weihua; Xu, Tielian; O'Shea, Kevin E.] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA.
[Cooper, William J.] Univ Calif Irvine, Urban Water Res Ctr, Dept Civil & Environm Engn, Irvine, CA 92697 USA.
[Dionysiou, Dionysios D.] Univ Cincinnati, Cincinnati, OH 45221 USA.
[De La Cruz, Armah A.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA.
RP O'Shea, KE (reprint author), Florida Int Univ, Dept Chem & Biochem, Univ Pk, Miami, FL 33199 USA.
EM osheak@fiu.edu
RI Song, Weihua/B-6931-2011; Cooper, William/D-4502-2011
OI Song, Weihua/0000-0001-7633-7919;
FU Office of Basic Energy Sciences, U.S. Department of Energy; U.S.
Environmental Protection Agency [RD-83322301]; NIH/NIEHS [ARCH
S11ESO11181]; University Graduate School at FIU
FX We thank the reviewers forvaluable suggestions and insights. Work
performed at the Radiation Laboratory, University of Notre Dame, which
is supported by the Office of Basic Energy Sciences, U.S. Department of
Energy. This research was funded in part by the U.S. Environmental
Protection Agency (RD-83322301). K.E.O. gratefully acknowledges support
from the NIH/NIEHS (ARCH S11ESO11181). T.X. is supported by a
Presidential Dissertation Fellowship from the University Graduate School
at FIU. This is contribution 29 from Urban Water Research Center,
University of California, Irvine.
NR 36
TC 35
Z9 36
U1 6
U2 49
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAR 1
PY 2009
VL 43
IS 5
BP 1487
EP 1492
DI 10.1021/es802282n
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 412XX
UT WOS:000263758600044
PM 19350924
ER
PT J
AU Kan, E
Huling, SG
AF Kan, Eunsung
Huling, Scott G.
TI Effects of Temperature and Acidic Pre-Treatment on Fenton-Driven
Oxidation of MTBE-Spent Granular Activated Carbon
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID DEGRADATION; SURFACE; IRON; OPTIMIZATION; ADSORPTION; DEPENDENCE;
REDUCTION; CATALYSTS; SUPPORT; REAGENT
AB The effects of temperature and acidic pretreatment on Fenton-driven chemical oxidation of methyl tort-butyl ether (MTBE)spent granular activated carbon (GAC)were investigated. Limiting factors in MTBE removal in GAC include the heterogeneous distribution of amended Far and slow intraparticle diffusive transport of MTBE and hydrogen peroxide (H(2)O(2)) into the "reactive zone". Acid pretreatment of GAC before Fe amendment altered the surface chemistry of the GAC, lowered the pH point of zero charge, and resulted in greater penetration and more uniform distribution of Fe in GAC. This led to a condition where Fe, MTBE, and H(2)O(2) coexisted over a larger volume of the GAC contributing to greater MTBE oxidation and removal. H(2)O(2) reaction and MTBE removal in GAC increased with temperature. Modeling H(2)O(2) transport and reaction in GAC indicated that H(2)O(2) penetration was inversely proportional with temperature and tortuosity, and occurred over a larger fraction of the total volume of small GAC particles (0.3 mm diameter) relative to large particles (1.2 mm diameter). Acidic pretreatment of GAC, Fe-amendment, elevated reaction temperature, and use of small GAC particles are operational parameters that improve Fenton-driven oxidation of MTBE in GAC.
C1 [Kan, Eunsung; Huling, Scott G.] CNR, Robert S Kerr Environm Res Ctr, Ada, OK 74820 USA.
[Kan, Eunsung] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Robert S Kerr Environm Res Ctr, Ada, OK 74820 USA.
RP Huling, SG (reprint author), CNR, Robert S Kerr Environm Res Ctr, POB 1198, Ada, OK 74820 USA.
EM huling.scott@epa.gov
FU U.S. Environmental Protection Agency
FX We acknowledge Drs. R. G. Arnold, W. P. Ela, and R. E. Sierka
(University of Arizona), and M. Blankenship, T. Pardue, and Dr. B.
Pivetz (Shaw Environmental Inc., Ada, OK) for their assistance. The U.S.
Environmental Protection Agency, through its Office of Research and
Development, funded and managed the research described here. It has not
been subjected to Agency review and therefore does not necessarily
reflect the views of the Agency, and no official endorsement should be
inferred.
NR 29
TC 39
Z9 41
U1 0
U2 28
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAR 1
PY 2009
VL 43
IS 5
BP 1493
EP 1499
DI 10.1021/es802360f
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 412XX
UT WOS:000263758600045
PM 19350925
ER
PT J
AU Lewis, MA
Devereux, R
AF Lewis, Michael A.
Devereux, Richard
TI NONNUTRIENT ANTHROPOGENIC CHEMICALS IN SEAGRASS ECOSYSTEMS: FATE AND
EFFECTS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Review
DE Seagrass; Anthropogenic chemicals; Fate; Effects; Summary
ID EELGRASS ZOSTERA-MARINA; STIPULACEA FORSK ASCHERS; HEAVY-METAL
CONCENTRATIONS; OCEANICA L. DELILE; RUPPIA-MARITIMA L; SHORT-TERM
UPTAKE; IN-SITU IMPACT; GULF-OF-MEXICO; POSIDONIA-OCEANICA;
THALASSIA-TESTUDINUM
AB Impacts of human-related chemicals, either alone or in combination with other stressors, are important to understand to prevent and reverse continuing worldwide seagrass declines. This review summarizes reported concentrations of anthropogenic chemicals in grass bed-associated surface waters, sediments, and plant tissues and phytotoxic concentrations. Fate information in seagrass-rooted sediments and overlying water is most available for trace metals. Toxicity results in aqueous exposures are available for at least 13 species and a variety of trace metals, pesticides, and petrochemicals. In contrast, results for chemical mixtures and chemicals in sediment matrices are uncommon. Contaminant bioaccumulation information is available for at least 23 species. The effects of plant age, tissue type, and time of collection have been commonly reported but not biological significance of the chemical residues. Experimental conditions have varied considerably in seagrass contaminant research and interspecific differences in chemical residues and chemical tolerances are common, which limits generalizations and extrapolations among species and chemicals. The few reported risk assessments have been usually local and limited to a few single chemicals and species representative of the south Australian and Mediterranean floras. Media-specific information describing exposure concentrations, toxic effect levels, and critical body burdens of common near-shore contaminants is needed for most species to support integrated risk assessments at multiple geographical scales and to evaluate the ability of numerical effects-based criteria to protect these marine angiosperms at risk.
C1 [Lewis, Michael A.; Devereux, Richard] US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
RP Lewis, MA (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM lewis.michael@epa.gov
RI Ross, Donald/F-7607-2012
OI Ross, Donald/0000-0002-8659-3833
NR 218
TC 37
Z9 37
U1 4
U2 29
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD MAR
PY 2009
VL 28
IS 3
BP 644
EP 661
DI 10.1897/08-201.1
PG 18
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 405DU
UT WOS:000263203700024
PM 19006414
ER
PT J
AU Reich, BJ
Fuentes, M
Burke, J
AF Reich, Brian J.
Fuentes, Montserrat
Burke, Janet
TI Analysis of the effects of ultrafine particulate matter while accounting
for human exposure
SO ENVIRONMETRICS
LA English
DT Article
DE ecological fallacy; human exposure; dynamic factor model; SHEDS;
ultrafine particles
ID CORONARY-HEART-DISEASE; OUTDOOR AIR-POLLUTION; MORTALITY; PARTICLES;
MODEL; FINE; PM2.5
AB Particulate matter (PM) has been associated with mortality in several epidemiological studies. The US EPA currently regulates PM(10) and PM(2.5) (mass concentration of particles with diameter less than 10 and 2.5 mu m, respectively), but it is not clear which size of particles are most responsible for adverse heath outcomes. A current hypothesis is that ultrafine particles with diameter less than 0.1 mu m are particularly harmful because their small size allows them to deeply penetrate the lungs. This paper investigates the association between exposure to particles of varying diameter and daily mortality. We propose a new dynamic Factor analysis model to relate the ambient concentrations of several sizes of particles with diameters ranging from 0.01 to 0.40 mu m with mortality. We introduce a Bayesian model that converts ambient concentrations into simulated personal exposure using the EPA's Stochastic Human Exposure and Dose Simulator, and relates simulated exposure with mortality. Using new data from Fresno, CA, we find that the 4-day lag of particles with diameter between 0.02 and 0.08 mu m is associated with mortality. This is consistent with the small particles hypothesis. Copyright (C) 2008 John Wiley & Sons, Ltd.
C1 [Reich, Brian J.; Fuentes, Montserrat] N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA.
[Burke, Janet] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Reich, BJ (reprint author), N Carolina State Univ, Dept Stat, 2501 Founders Dr,Box 8203, Raleigh, NC 27695 USA.
EM reich@stat.ncsu.edu
RI Wang, Linden/M-6617-2014
FU National Science Foundation [DMS 0354189, DMS 0353029]
FX The authors thank Lance McCluney of the U.S. E.P.A. for providing the CO
data. The U.S. E.P.A.'s Office of Research and Development partially
collaborated in the research derived here. Although it has been reviewed
by EPA and approved for publication, it does not necessarily reflect the
Agency's policies or views. The research conducted by Reich has been
supported by National Science Foundation grant DMS 0354189, and Fuentes
has been partly Supported by National Science Foundation grant DMS
0353029.
NR 28
TC 19
Z9 20
U1 0
U2 8
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1180-4009
J9 ENVIRONMETRICS
JI Environmetrics
PD MAR
PY 2009
VL 20
IS 2
BP 131
EP 146
DI 10.1002/env.915
PG 16
WC Environmental Sciences; Mathematics, Interdisciplinary Applications;
Statistics & Probability
SC Environmental Sciences & Ecology; Mathematics
GA 463DE
UT WOS:000267408400002
ER
PT J
AU Bateson, TF
AF Bateson, Thomas F.
TI Gamma Regression of Interevent Waiting Times Versus Poisson Regression
of Daily Event Counts Inside the Epidemiologist's Toolbox-Selecting the
Best Modeling Tools for the Job
SO EPIDEMIOLOGY
LA English
DT Editorial Material
C1 US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
RP Bateson, TF (reprint author), US EPA, Natl Ctr Environm Assessment, 1200 Penn Ave NW,Mail Code 8623P, Washington, DC 20460 USA.
EM Bateson.Thomas@epa.gov
NR 7
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1044-3983
J9 EPIDEMIOLOGY
JI Epidemiology
PD MAR
PY 2009
VL 20
IS 2
BP 202
EP 204
DI 10.1097/EDE.0b013e3181977688
PG 3
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 412HH
UT WOS:000263715400010
PM 19234413
ER
PT J
AU Brown, CA
Ozretich, RJ
AF Brown, Cheryl A.
Ozretich, Robert J.
TI Coupling Between the Coastal Ocean and Yaquina Bay, Oregon: Importance
of Oceanic Inputs Relative to Other Nitrogen Sources
SO ESTUARIES AND COASTS
LA English
DT Article
DE Ocean input; Upwelling; Nutrient sources; Yaquina estuary
ID NORTHERN CALIFORNIA CURRENT; SUB-ARCTIC WATER; COLD HALOCLINE;
UNITED-STATES; EL-NINO; NUTRIENT; ESTUARY; PACIFIC; USA; CHLOROPHYLL
AB Understanding of the role of oceanic input in nutrient loadings is important for understanding nutrient and phytoplankton dynamics in estuaries adjacent to coastal upwelling regions as well as determining the natural background conditions. We examined the nitrogen sources to Yaquina Estuary (Oregon, USA) as well as the relationships between physical forcing and gross oceanic input of nutrients and phytoplankton. The ocean is the dominant source of dissolved inorganic nitrogen (DIN) and phosphate to the lower portion of Yaquina Bay during the dry season (May through October). During this time interval, high levels of dissolved inorganic nitrogen (primarily in the form of nitrate) and phosphate entering the estuary lag upwelling favorable winds by 2 days. The nitrate and phosphate levels entering the bay associated with coastal upwelling are correlated with the wind stress integrated over times scales of 4-6 days. In addition, there is a significant import of chlorophyll a to the bay from the coastal ocean region, particularly during July and August. Variations in flood-tide chlorophyll a lag upwelling favorable winds by 6 days, suggesting that it takes this amount of time for phytoplankton to utilize the recently upwelled nitrogen and be transported across the shelf into the estuary. Variations in water properties determined by ocean conditions propagate approximately 11-13 km into the estuary. Comparison of nitrogen sources to Yaquina Bay shows that the ocean is the dominant source during the dry season (May to October) and the river is the dominant source during the wet season with watershed nitrogen inputs primarily associated with nitrogen fixation on forest lands.
C1 [Brown, Cheryl A.] US EPA, Western Ecol Div, Pacific Coastal Ecol Branch, Newport, OR 97365 USA.
[Ozretich, Robert J.] US EPA, Western Ecol Div, Corvallis, OR 97333 USA.
RP Brown, CA (reprint author), US EPA, Western Ecol Div, Pacific Coastal Ecol Branch, 2111 SE Marine Sci Ctr Dr, Newport, OR 97365 USA.
EM brown.cheryl@epa.gov
NR 49
TC 29
Z9 30
U1 1
U2 23
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1559-2723
EI 1559-2731
J9 ESTUAR COAST
JI Estuaries Coasts
PD MAR
PY 2009
VL 32
IS 2
BP 219
EP 237
DI 10.1007/s12237-008-9128-6
PG 19
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 407KJ
UT WOS:000263361700001
ER
PT J
AU Murrell, MC
Campbell, JG
Hagy, JD
Caffrey, JM
AF Murrell, Michael C.
Campbell, Jed G.
Hagy, James D., III
Caffrey, Jane M.
TI Effects of irradiance on benthic and water column processes in a Gulf of
Mexico estuary: Pensacola Bay, Florida, USA
SO ESTUARINE COASTAL AND SHELF SCIENCE
LA English
DT Article
DE dissolved oxygen; respiration; primary production; nutrient cycles;
phytobenthos; net ecosystem metabolism; USA; Florida; Pensacola Bay
ID NET ECOSYSTEM METABOLISM; ORGANIC-CARBON BALANCE; PHOTOSYNTHETIC
PARAMETERS; SUBTROPICAL ESTUARY; OXYGEN-CONSUMPTION; CORE INCUBATIONS;
MARINE-SEDIMENTS; NUTRIENT FLUXES; NITROGEN FLUXES; DEPTH GRADIENT
AB We examined the effect of light on water column and benthic fluxes in the Pensacola Bay estuary, a river-dominated system in the northeastern Gulf of Mexico. Measurements were made during the summers of 2003 and 2004 on 16 dates distributed along depth and salinity gradients. Dissolved oxygen fluxes were measured on replicate sediment and water column samples exposed to a gradient of photosynthetically active radiation. Sediment inorganic nutrient (NH(4)(+), NO(3)(-), PO(4)(3-)) fluxes were measured. The response of dissolved oxygen fluxes to variation in light was fit to a photosynthesis-irradiance model and the parameter estimates were used to calculate daily integrated production in the water column and the benthos. The results suggest that shoal environments supported substantial benthic productivity, averaging 13.6 +/- 4.7 mmol O(2) m(-2) d(-1), whereas channel environments supported low benthic productivity, averaging 0.5 +/- 03 mmol O(2) m(-2) d(-1) (+/- SE). Estimates of baywide microphytobenthic productivity ranged from 8.1 to 16.5 mmol O(2) m(-2) d(-1), comprising about 16-32% of total system productivity. Benthic and water column dark respiration averaged 15.2 +/- 3.2 and 33.6 +/- 3.7 mmol O(2) m(-2) d(-1), respectively inorganic nutrient fluxes were generally low compared to relevant estuarine literature values, and responded minimally to light exposure. Across all stations, nutrient fluxes from sediments to the water column averaged 1.11 +/- 0.98 mmol m(-2) d(-1) for NH(4)(+), 0.58 +/- 1.08 mmol m(-2) d(-1) for NO(3)(-), 0.01 +/- 0.09 mmol m(-2) d(-1) for PO(4)(3-). The results of this study illustrate how light reaching the sediments is an important modulator of benthic nutrient and oxygen dynamics in shallow estuarine systems. Published by Elsevier Ltd.
C1 [Murrell, Michael C.; Campbell, Jed G.; Hagy, James D., III] US EPA, Gulf Ecol Div, Gulf Breeze, FL 32561 USA.
[Caffrey, Jane M.] Univ W Florida, Ctr Environm Diagnost & Bioremediat, Pensacola, FL 32514 USA.
RP Murrell, MC (reprint author), US EPA, Gulf Ecol Div, 1 Sabine Isl Dr, Gulf Breeze, FL 32561 USA.
EM murrell.michael@epa.gov
FU US EPA; National Health and Environmental Effects Research Laboratory.;
National Science Foundation [OCE-0352221]
FX This study was made possible by the excellent field and lab support
provided by R. Quarles, L Smith, V. Engle, R. Stanley, H. Reed, K.
Smith, and S. Duffy. Helpful comments from R. Greene, J. Lehrter, E.
Smith, and several anonymous reviewers have improved the manuscript.
This study was funded by the US EPA, National Health and Environmental
Effects Research Laboratory. J. Caffrey received support from a National
Science Foundation grant (OCE-0352221). The contents are solely the
views of the authors and use of trade names or commercial products does
not constitute endorsement. Contribution # 1339 from the Gulf Ecology
Division.
NR 59
TC 22
Z9 27
U1 3
U2 20
PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0272-7714
J9 ESTUAR COAST SHELF S
JI Estuar. Coast. Shelf Sci.
PD MAR 1
PY 2009
VL 81
IS 4
BP 501
EP 512
DI 10.1016/j.ecss.2008.12.002
PG 12
WC Marine & Freshwater Biology; Oceanography
SC Marine & Freshwater Biology; Oceanography
GA 411KM
UT WOS:000263648500007
ER
PT J
AU Nikolova, PS
Raspe, S
Andersen, CP
Mainiero, R
Blaschke, H
Matyssek, R
Haberle, KH
AF Nikolova, Petia S.
Raspe, Stephan
Andersen, Christian P.
Mainiero, Raphael
Blaschke, Helmut
Matyssek, Rainer
Haeberle, Karl-Heinz
TI Effects of the extreme drought in 2003 on soil respiration in a mixed
forest
SO EUROPEAN JOURNAL OF FOREST RESEARCH
LA English
DT Article
DE Fagus sylvatica; Picea abies; Soil respiration components; Water
availibility; Temperature; Root exclusion; Carbon partitioning
ID FAGUS-SYLVATICA L.; NORWAY SPRUCE; CO2 EFFLUX; EUROPEAN BEECH;
CARBON-DIOXIDE; ROOT RESPIRATION; ECOSYSTEM RESPIRATION; ORGANIC
HORIZONS; HARDWOOD FOREST; ELEMENT FLUXES
AB We present a field study on the drought effects on total soil respiration (SR(t)) and its components, i.e., "autotrophic'' (SR(a): by roots/mycorrhizosphere) and "heterotrophic'' respiration (SR(h): by microorganisms and soil fauna in bulk soil), in a mature European beech/Norway spruce forest. SR(a) and SR(h) were distinguished underneath groups of beech and spruce trees using the root exclusion method. Seasonal courses of SR(a) and SR(h) were studied from 2002 to 2004, with the summer of 2003 being extraordinarily warm and dry in Central Europe. We (1) analyzed the soil temperature (T(s)) and moisture sensitivity of SR(a) and SR(h) underneath both tree species, and (2) examined whether drought caused differential decline of SR(a) between spruce and beech. Throughout the study period, SR(a) of beech accounted for 45-55% of SRt, independent of the soil water regime; in contrast, SR(a) was significantly reduced during drought in spruce, and amounted then to only 25% of SR(t). In parallel, fine-root production was decreased during 2003 by a factor of six in spruce (from 750 to 130 mg l(-1) a(-1)), but remained at levels similar to those in 2002 in beech (about 470 mg l(-1) a(-1)). This species-specific root response to drought was related to a stronger decline of SR(a) in spruce (by about 70%) compared to beech (by about 50%). The sensitivity of SR(a) and SR(h) to changing T(s) and available soil water was stronger in SR(a) than SR(h) in spruce, but not so in beech. It is concluded that SR(a) determines the effect of prolonged drought on the C efflux from soil to a larger extent in spruce than beech, having potential implications for respective forest types.
C1 [Nikolova, Petia S.; Blaschke, Helmut; Matyssek, Rainer; Haeberle, Karl-Heinz] Tech Univ Munich, Weihenstephan Ctr Life & Food Sci, D-85354 Freising Weihenstephan, Germany.
[Raspe, Stephan] Bayer Landesanstalt Wald & Forstwirtschaft, D-85354 Freising Weihenstephan, Germany.
[Andersen, Christian P.] US EPA, Western Ecol Div, Natl Hlth & Environm Effects Res Lab, Corvallis, OR 97333 USA.
[Mainiero, Raphael] Univ Ulm, Inst Systemat Bot & Ecol, D-89081 Ulm, Germany.
RP Haberle, KH (reprint author), Tech Univ Munich, Weihenstephan Ctr Life & Food Sci, Hochanger 13, D-85354 Freising Weihenstephan, Germany.
EM haeberle@wzw.tum.de
FU Deutsche Forschungsgemeinschaft (DFG) [SFB 607]
FX The authors gratefully acknowledge funding through SFB 607 "Growth and
Parasite Defence-Competition for Resources in Economic Plants from
Agronomy and Forestry'' provided by the Deutsche Forschungsgemeinschaft
(DFG). We also thank Ivan Nikolov for his skilful support of the
fine-root analyses and soil respiration measurements, Thomas Feuerbach
for his precise technical assistance, Dr. Holger Holland-Moritz ( LWF:
Bayerische Landesanstalt fur Wald und Forstwirtschaft, Freising) for
helpful comments on statistical evaluations, Prof. Dr. Anton Hartmann (
Helmholtz Center Munich) for hints on literature, and Philip Wipfler (
Chair of Forest Yield Science, Technische Universitat Munchen) for
supplying the stem diameter increment data. We also thank Dr. Carolyn
Scagel, USDA-ARS, for helpful suggestions on an earlier version of this
manuscript. The information in this document has been subjected to EPA
peer and administrative review, and it has been approved for publication
as an EPA document. Mention of trade names or commercial products does
not constitute endorsement or recommendation for use.
NR 75
TC 32
Z9 41
U1 7
U2 46
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1612-4669
J9 EUR J FOREST RES
JI Eur. J. For. Res.
PD MAR
PY 2009
VL 128
IS 2
BP 87
EP 98
DI 10.1007/s10342-008-0218-6
PG 12
WC Forestry
SC Forestry
GA 429UD
UT WOS:000264944700002
ER
PT J
AU Moser, GJ
Foley, J
Burnett, M
Goldsworthy, TL
Maronpot, R
AF Moser, Glenda J.
Foley, Julie
Burnett, Merrie
Goldsworthy, Thomas L.
Maronpot, Robert
TI Furan-induced dose-response relationships for liver cytotoxicity, cell
proliferation, and tumorigenicity (furan-induced liver tumorigenicity)
SO EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
LA English
DT Article
DE Furan; Mouse liver carcinogenesis; Cytotoxic; Proliferation;
Inflammation
ID INCREASED CARCINOGENICITY; FISCHER-344 RATS; B6C3F(1) MICE; HEPATOCYTE;
APOPTOSIS; TESTS; HEPATOCARCINOGENESIS; EXPRESSION; REGRESSION; GROWTH
AB Rodent studies of furan are associated with liver cell necrosis, release or liver-associated enzymes, increased hepatocyte proliferation, and hepatocarcinogenesis. For carcinogens whose proposed mode of action is cytolethality, it is hypothesized that the dose-response curve for tumor development would parallel the dose-response curve for cell death with compensatory proliferation in the target organ. To prospectively test this hypothesis, female B6C3F(1), mice were exposed to furan at carcinogenic doses and lower for 3 weeks or 2 years. At 3 weeks and in the 2-year study, there were dose-dependent and significant increases in hepatic cytotoxicity at 1.0, 2.0, 4.0, and 8.0 mg furan/kg. For cell proliferation as measured by 5-bromo-2'-deoxyuridine (BrdU) labeling index (LI), there was a statistically significant trend with increasing dose levels of furan and increased LI at 8.0 mg/kg. There was an increased incidence of foci of altered hepatocytes, hepatocellular adenomas, and adenomas or carcinomas at 4.0 and 8.0 mg/kg and carcinomas at 8.0 mg/kg. The multiplicity of microscopic tumors was increased and latency was decreased in mice exposed to 8.0 mg/kg. Prevalence of hepatic nodules at necropsy was increased in mice exposed to 4.0 and 8.0 mg/kg. Data demonstrate an association among furan-induced hepatic cytotoxicity, compensatory cell replication, and liver tumor formation in mice; at high doses >= 4.0 mg/kg, furan induced hepatotoxicity, compensatory cell replication and tumorigenesis in a dose-related manner, while furan did not produce tumors at cytotoxic doses of 1.0 and 2.0 mg/kg. (C) 2008 Published by Elsevier GmbH.
C1 [Moser, Glenda J.; Burnett, Merrie; Goldsworthy, Thomas L.] Integrated Lab Syst Inc, Res Triangle Pk, NC 27709 USA.
[Foley, Julie; Maronpot, Robert] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC 27709 USA.
RP Moser, GJ (reprint author), Integrated Lab Syst Inc, POB 13501, Res Triangle Pk, NC 27709 USA.
EM gmoser@ils-inc.com
FU NIH, NIEHS [N01-ES-95434]
FX We thank Grace Kissling for statistical support, Clinical Pathology
Laboratory at NIEHS for enzyme analyses, Greg Kedderis for initial study
design considerations, and the ILS animal care and toxicology and
histology staff. This research was supported by the Intramural Research
Program of the NIH, NIEHS, and contract no. N01-ES-95434.
NR 39
TC 45
Z9 46
U1 1
U2 12
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0940-2993
J9 EXP TOXICOL PATHOL
JI Exp. Toxicol. Pathol.
PD MAR
PY 2009
VL 61
IS 2
BP 101
EP 111
DI 10.1016/j.etp.2008.06.006
PG 11
WC Pathology; Toxicology
SC Pathology; Toxicology
GA 423CL
UT WOS:000264473900002
PM 18809303
ER
PT J
AU Reif, DM
Motsinger-Reif, AA
McKinney, BA
Rock, MT
Crowe, JE
Moore, JH
AF Reif, D. M.
Motsinger-Reif, A. A.
McKinney, B. A.
Rock, M. T.
Crowe, J. E., Jr.
Moore, J. H.
TI Integrated analysis of genetic and proteomic data identifies biomarkers
associated with adverse events following smallpox vaccination
SO GENES AND IMMUNITY
LA English
DT Article
DE smallpox; Random Forests; integrated analysis; genetic; proteomic;
interactions
ID RANDOM FORESTS; HUMAN MONOCYTES; EXPRESSION; IL-4; AMPLIFICATION;
INFLAMMATION; APOPTOSIS
AB Complex clinical outcomes, such as adverse reaction to vaccination, arise from the concerted interactions among the myriad components of a biological system. Therefore, comprehensive etiological models can be developed only through the integrated study of multiple types of experimental data. In this study, we apply this paradigm to high-dimensional genetic and proteomic data collected to elucidate the mechanisms underlying the development of adverse events (AEs) in patients after smallpox vaccination. As vaccination was successful in all of the patients under study, the AE outcomes reported likely represent the result of interactions among immune system components that result in excessive or prolonged immune stimulation. In this study, we examined 1442 genetic variables (single nucleotide polymorphisms) and 108 proteomic variables (serum cytokine concentrations) to model AE risk. To accomplish this daunting analytical task, we employed the Random Forests (RF) method to filter the most important attributes, then we used the selected attributes to build a final decision tree model. This strategy is well suited to integrated analysis, as relevant attributes may be selected from categorical or continuous data. Importantly, RF is a natural approach for studying the type of gene-gene, gene-protein and protein-protein interactions we hypothesize to be involved in the development of clinical AEs. RF importance scores for particular attributes take interactions into account, and there may be interactions across data types. Combining information from previous studies on AEs related to smallpox vaccination with the genetic and proteomic attributes identified by RF, we built a comprehensive model of AE development that includes the cytokines intercellular adhesion molecule-1 (ICAM-1 or CD54), interleukin-10 (IL-10), and colony stimulating factor-3 (CSF-3 or G-CSF) and a genetic polymorphism in the cyokine gene interleukin-4 (IL4). The biological factors included in the model support our hypothesized mechanism for the development of AEs involving prolonged stimulation of inflammatory pathways and an imbalance of normal tissue damage repair pathways. This study shows the utility of RF for such analytical tasks, while both enhancing and reinforcing our working model of AE development after smallpox vaccination.
C1 [Reif, D. M.] US EPA, Natl Ctr Computat Toxicol, Res Triangle Pk, NC 27711 USA.
[Motsinger-Reif, A. A.] N Carolina State Univ, Bioinformat Res Ctr, Dept Stat, Raleigh, NC 27695 USA.
[McKinney, B. A.] Univ Alabama Birmingham, Sch Med, Dept Genet, Birmingham, AL USA.
[Rock, M. T.; Crowe, J. E., Jr.] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA.
[Crowe, J. E., Jr.] Vanderbilt Univ, Med Ctr, Dept Microbiol & Immunol, Nashville, TN 37232 USA.
[Crowe, J. E., Jr.] Vanderbilt Univ, Med Ctr, Program Vaccine Sci, Nashville, TN 37232 USA.
[Moore, J. H.] Dartmouth Med Sch, Dept Genet, Lebanon, NH USA.
[Moore, J. H.] Dartmouth Med Sch, Computat Genet Lab, Lebanon, NH USA.
RP Reif, DM (reprint author), US EPA, Natl Ctr Computat Toxicol, D343-03,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM reif.david@epa.gov
RI Crowe, James/B-5549-2009;
OI Crowe, James/0000-0002-0049-1079; Reif, David/0000-0001-7815-6767
FU National Institutes of Health (NIH)/National Institute of Allergy and
Infectious Diseases (NIAID) [N01-AI-25462, DMID 02-054, R21-AI-59365,
K25-AI-064625, R01-AI-59694]; NIH/National Institute of General Medical
Sciences (NIGMS) [R01-GM-2758]
FX This work was supported by the National Institutes of Health
(NIH)/National Institute of Allergy and Infectious Diseases (NIAID)
Vaccine Trials and Evaluation Unit (contract N01-AI-25462, study DMID
02-054); NIH/NIAID (Grants R21-AI-59365, K25-AI-064625 and R01-AI-59694)
and NIH/National Institute of General Medical Sciences (NIGMS) (Grant
R01-GM-2758). Cytokine analysis was a kind gift of Stephen Kingsmore,
PhD, and Molecular Staging Incorporated. Genotype analysis was a kind
gift of Stephen Chanock, MD, and the NCI Center for Cancer Research.
Kathryn Edwards, MD, coordinated the original acquisition of the data
analyzed for this study. The United States Environmental Protection
Agency (EPA), through its Office of Research and Development,
collaborated in the research described here. It has been subjected to
Agency review and approved for publication, although it does not
necessarily represent the views or polices of the US EPA.
NR 40
TC 33
Z9 33
U1 2
U2 6
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1466-4879
EI 1476-5470
J9 GENES IMMUN
JI Genes Immun.
PD MAR
PY 2009
VL 10
IS 2
BP 112
EP 119
DI 10.1038/gene.2008.80
PG 8
WC Genetics & Heredity; Immunology
SC Genetics & Heredity; Immunology
GA 415AD
UT WOS:000263905800002
PM 18923431
ER
PT J
AU Barakat, A
Mercer, B
Cooper, E
Chung, HM
AF Barakat, Ala
Mercer, Bettie
Cooper, Emilie
Chung, Hui-Min
TI Examining Requirement for Formation of Functional Presenilin Proteins
and Their Processing Events In Vivo
SO GENESIS
LA English
DT Article
DE Presenilin; gamma-secretase; Presenilinase-mediated endoproteolysis;
Notch; Drosophila
ID GAMMA-SECRETASE COMPLEX; MEDIATED TRANSMEMBRANE CLEAVAGE;
CAENORHABDITIS-ELEGANS; SIGNAL-TRANSDUCTION; ALZHEIMERS-DISEASE;
BETA-CATENIN; WING MARGIN; NOTCH; DROSOPHILA; ENDOPROTEOLYSIS
AB Presenilin (Psn) is a multipass transmembrane protein that functions as the catalytic subunit of gamma-secretase for mediating intramembrane cleavage of type I transmembrane proteins. Normally active Psn is in the form of a heterodimer composed by its N-terminal and C-terminal fragments that are generated from a Presenilinase-mediated endoproteolytic cleavage within its large cytosolic loop during assembly of the protease complex. Using the Psn forms that either bypass or disable Presenilinase-mediated endoproteolysis, and a Psn form that has most of the large cytosolic loop deleted, we have established an in vivo system to enable investigations of Psn functional domains in Drosophila. We show that the Presenilinase-mediated endoproteolytic event is not essential for producing Psn activity during animal development, and is regulated by integrity of the large cytosolic loop of Psn in Drosophila. The Psn transgenic flies described here could be applied to a broad range of studies on Psn functioning and its related gamma-secretase activity at any developmental stage. genesis 47:161-168, 2009. (c) 2009 Wiley-Liss, Inc.
C1 [Barakat, Ala; Mercer, Bettie; Cooper, Emilie; Chung, Hui-Min] Univ W Florida, Dept Biol, Pensacola, FL 32514 USA.
[Cooper, Emilie] US EPA, Gulf Ecol Div, Gulf Breeze, FL USA.
RP Chung, HM (reprint author), Univ W Florida, Dept Biol, 11000 Univ Pkwy, Pensacola, FL 32514 USA.
EM hchung@uwf.edu
FU NIH [1R1 5AG028448-01]; University of West Florida
FX Contract grant sponsor: NIH (AREA R15 grant), Contract grant number: 1R1
5AG028448-01 (to H.-M.C.); Contract grant sponsor: University of West
Florida
NR 47
TC 1
Z9 1
U1 0
U2 0
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1526-954X
J9 GENESIS
JI Genesis
PD MAR
PY 2009
VL 47
IS 3
BP 161
EP 168
DI 10.1002/dvg.20475
PG 8
WC Developmental Biology; Genetics & Heredity
SC Developmental Biology; Genetics & Heredity
GA 425RT
UT WOS:000264655500004
PM 19191327
ER
PT J
AU Cooper, E
Deng, WM
Chung, HM
AF Cooper, Emilie
Deng, Wu-Min
Chung, Hui-Min
TI Aph-1 Is Required to Regulate Presenilin-Mediated gamma-Secretase
Activity and Cell Survival in Drosophila Wing Development
SO GENESIS
LA English
DT Article
DE Presenilin; Aph-1; gamma-secretase; Notch; cell survival
ID TRANSMEMBRANE CLEAVAGE; NOTCH; EXPRESSION; PATHWAY; COMPLEX; MARGIN
AB Aph-1 is a multipass transmembrane protein and an essential component of the Presenilin (Psn)mediated gamma-secretase complex. During protease assembly, Aph-1 stabilizes the newly synthesized Psn holoprotein to facilitate generation of the active form of Psn, which is a Psn-NTF/Psn-CTF heterodimer produced through a Presenilinase-initiated endoproteolytic cleavage of the Psn holoprotein. Although it is clear that loss of Aph-1 activity leads to failure of Psn heterodimer formation, little is understood about whether Aph-1 plays a role in regulating gamma-secretase activity in addition to assisting Psn maturation. Using various modified Psn forms that do not require endoproteolysis or have a large deletion of the cytosolic loop, we show that in Drosophila Aph-1 is still required for gamma-secretase activity independent of its role in promoting Psn endoproteolysis. In addition, our results indicate that Aph-1 is required to promote cell survival in the wing imaginal disc; aph-1 mutant cells are lost either through cell death or because of a defect in cell proliferation. This function of Aph-1 is independent of its role in regulating gamma-secretase activity, but possibly involves downregulating the activity of uncleaved Psn holoprotein. genesis 47:169-174, 2009. (c) 2009 Wiley-Liss, Inc.
C1 [Cooper, Emilie; Chung, Hui-Min] Univ W Florida, Dept Biol, Pensacola, FL 32514 USA.
[Cooper, Emilie] US EPA, Gulf Ecol Div, Gulf Breeze, FL USA.
[Deng, Wu-Min] Florida State Univ, Dept Biol Sci, Tallahassee, FL 32306 USA.
RP Chung, HM (reprint author), Univ W Florida, Dept Biol, 11000 Univ Pkwy, Pensacola, FL 32514 USA.
EM hchung@uwf.edu
FU NIH [1R15AG028448-01]; University of West Florida.
FX Contract grant sponsor: NIH (AREA 1115 grant), Contract grant number:
1R15AG028448-01 (to H-MC), contract grant sponsor: University of West
Florida.
NR 16
TC 1
Z9 1
U1 0
U2 1
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1526-954X
J9 GENESIS
JI Genesis
PD MAR
PY 2009
VL 47
IS 3
BP 169
EP 174
DI 10.1002/dvg.20478
PG 6
WC Developmental Biology; Genetics & Heredity
SC Developmental Biology; Genetics & Heredity
GA 425RT
UT WOS:000264655500005
PM 19191330
ER
PT J
AU Job, C
AF Job, Charles
TI Change in Number of Ground Water Systems Providing Drinking Water
SO GROUND WATER MONITORING AND REMEDIATION
LA English
DT Article
C1 US EPA, Off Ground Water & Drinking Water, Washington, DC 20460 USA.
RP Job, C (reprint author), US EPA, Off Ground Water & Drinking Water, Washington, DC 20460 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1069-3629
J9 GROUND WATER MONIT R
JI Ground Water Monit. Remediat.
PD SPR
PY 2009
VL 29
IS 2
BP 40
EP 41
DI 10.1111/j.1745-6592.2009.01237.x
PG 2
WC Water Resources
SC Water Resources
GA 447EP
UT WOS:000266174700002
ER
PT J
AU Mason, SM
Messer, LC
Laraia, BA
Mendola, P
AF Mason, Susan M.
Messer, Lynne C.
Laraia, Barbara A.
Mendola, Pauline
TI Segregation and preterm birth: The effects of neighborhood racial
composition in North Carolina
SO HEALTH & PLACE
LA English
DT Article
DE Preterm birth; Residential segregation; Racial density; Neighborhood
ID NEW-YORK-CITY; RESIDENTIAL SEGREGATION; UNITED-STATES; MULTILEVEL
ANALYSIS; AFRICAN-AMERICAN; METROPOLITAN-AREAS; INFANT-MORTALITY;
RISK-FACTORS; WHITE WOMEN; BLACK
AB Epidemiologic research suggests that racial segregation is associated with poor health among blacks in the United States (US). We used geocoded birth records and US census data to investigate whether neighborhood-level percent black is associated with preterm birth (PTB) for black and white women in two counties in the southern US, whether area-level deprivation modifies this association, and whether the association is influenced by the choice of geographic unit used to approximate a neighborhood. A 20%-point increase in tract-level percent black was found to be associated with increased PTB odds in white (OR= 1.09, 95% CI: 1.01, 1.18) and black (OR = 1.05. 95% CI: 0.99, 1.11) women. These small associations were similar to those observed in other US regions. Effects were robust to choice of neighborhood proxy and were not modified by area-level deprivation. (c) 2008 Elsevier Ltd. All rights reserved.
C1 [Mason, Susan M.] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA.
[Messer, Lynne C.] US EPA, NHEERL, Human Studies Div, Res Triangle Pk, NC 27711 USA.
[Laraia, Barbara A.] Univ Calif San Francisco, Prevent Sci Grp, San Francisco, CA 94143 USA.
[Mendola, Pauline] Natl Ctr Hlth Stat, Hyattsville, MD 20782 USA.
RP Mason, SM (reprint author), Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, CB 4635, Chapel Hill, NC 27599 USA.
EM ssmars@email.unc.edu; messer.lynne@epa.gov; laraiab@chc.ucsf.edu;
pim9@cdc.gov
OI Mendola, Pauline/0000-0001-5330-2844
FU NICHD NIH HHS [T32 HD007168, K01 HD047122, T32 HD007168-24]
NR 48
TC 30
Z9 30
U1 2
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1353-8292
J9 HEALTH PLACE
JI Health Place
PD MAR
PY 2009
VL 15
IS 1
BP 1
EP 9
DI 10.1016/j.healthplace.2008.01.007
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 382WO
UT WOS:000261636300001
PM 18359264
ER
PT J
AU Olivier, M
Petitjean, A
Teague, J
Forbes, S
Dunnick, JK
den Dunnen, JT
Langerod, A
Wilkinson, JM
Vihinen, M
Cotton, RGH
Hainaut, P
AF Olivier, M.
Petitjean, A.
Teague, J.
Forbes, S.
Dunnick, J. K.
den Dunnen, J. T.
Langerod, A.
Wilkinson, J. M.
Vihinen, M.
Cotton, R. G. H.
Hainaut, P.
TI Somatic Mutation Databases as Tools for Molecular Epidemiology and
Molecular Pathology of Cancer: Proposed Guidelines for Improving Data
Collection, Distribution, and Integration
SO HUMAN MUTATION
LA English
DT Article
DE somatic mutation; database; standards
ID RECOMMENDATIONS
AB There are currently less than 40 locus-specific databases (LSDBs) and one large general database that curate data on somatic mutations in human cancer genes. These databases have different scope and use different annotation standards and database systems, resulting in duplicated efforts in data curation, and making it difficult for users to find clear and consistent information. As data related to somatic mutations are generated at an increasing pace it is urgent to create a framework for improving the collecting of this information and making it more accessible to clinicians, scientists, and epidemiologists to facilitate research on biomarkers. Here we propose a data flow for improving the connectivity between existing databases and we provide practical guidelines for data reporting, database contents, and annotation standards. These proposals are based on common standards recommended by the Human Genome Variation Society (HGVS) with additions related to specific requirements of somatic mutations in cancer. Indeed, somatic mutations may be used in molecular pathology and clinical studies to characterize tumor types, help treatment choice, predict response to treatment and patient outcome, or in epidemiological studies as markers for tumor etiology or exposure assessment. Thus, specific annotations are required to cover these diverse research topics. This initiative is meant to promote collaboration and discussion on these issues and the development of adequate resources that would avoid the loss of extremely valuable information generated by years of basic and clinical research. Hum Mutat 30, 275-282, 2009. (C) 2008 Wiley-Liss, Inc.
C1 [Olivier, M.; Petitjean, A.; Hainaut, P.] IARC, Grp Mol Carcinogenesis & Biomarkers, World Hlth Org, F-69372 Lyon, France.
[Teague, J.; Forbes, S.] Wellcome Trust Sanger Inst, Canc Genome Project, Cambridge, England.
[Dunnick, J. K.] Natl Inst Environm Hlth Sci, Toxicol Operat Branch, Res Triangle Pk, NC USA.
[den Dunnen, J. T.] Leiden Univ, Med Ctr, Leiden, Netherlands.
[Langerod, A.] Univ Oslo, Rikshosp, Radiumhosp Med Ctr, Dept Genet,Inst Canc Res, N-0027 Oslo, Norway.
[Wilkinson, J. M.] NCRI, Canc Informat Initiat, London, England.
[Vihinen, M.] Univ Tampere, Inst Med Technol, FIN-33101 Tampere, Finland.
[Cotton, R. G. H.] Tampere Univ Hosp, Tampere, Finland.
[Vihinen, M.] St Vincents Hosp, Genom Disorders Res Ctr, Melbourne, Vic, Australia.
RP Olivier, M (reprint author), IARC, Grp Mol Carcinogenesis & Biomarkers, World Hlth Org, 150 Cours Albert Thomas, F-69372 Lyon, France.
EM molivier@iarc.fr
RI Vihinen, Mauno/A-8452-2012; Hainaut, Pierre /B-6018-2012; Olivier,
Magali/G-3728-2010
OI Vihinen, Mauno/0000-0002-9614-7976; Hainaut, Pierre
/0000-0002-1303-1610; Olivier, Magali/0000-0002-8202-342X
FU IARC; EC
FX These recommendations were prepared during a working group session of a
training workshop on mutation databases that was held at IARC in Lyon in
July 2007. The workshop was funded by IARC and by EC FP6. This
publication reflects the author's views and not necessarily those of the
European Community (EC). The Community is not liable for any use that
may be made of the information contained herein.
NR 15
TC 11
Z9 13
U1 1
U2 1
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1059-7794
J9 HUM MUTAT
JI Hum. Mutat.
PD MAR
PY 2009
VL 30
IS 3
BP 275
EP 282
DI 10.1002/humu.20832
PG 8
WC Genetics & Heredity
SC Genetics & Heredity
GA 416NB
UT WOS:000264011700001
PM 19006239
ER
PT J
AU Zhu, WY
Gilmour, MI
AF Zhu, Weiyan
Gilmour, M. Ian
TI Comparison of allergic lung disease in three mouse strains after
systemic or mucosal sensitization with ovalbumin antigen
SO IMMUNOGENETICS
LA English
DT Article
DE Asthma; Genetic variability; Pulmonary function; Th2-type response
ID DIESEL EXHAUST PARTICLES; AIRWAY HYPERRESPONSIVENESS; INHALED ANTIGEN;
MICE; ASTHMA; MODEL; HYPERREACTIVITY; EOSINOPHILIA; INFLAMMATION;
RESPONSES
AB Murine models of allergic lung disease have many similar traits to asthma in humans and can be used to investigate mechanisms of allergic sensitization and susceptibility factors associated with disease severity. The purpose of this study was to determine strain differences in allergic airway inflammation, immunoglobulin production, and changes in respiratory responses between systemic and mucosal sensitization routes in BALB/cJ, FVB/NJ, and C57BL/6J, and to provide correlations between immune and pathophysiological endpoints. After a single intranasal ovalbumin (OVA) challenge, all three strains of mice systemically sensitized with OVA and adjuvant exhibited higher airflow limitation than non-sensitized mice. No changes were seen in mice that were pre-sensitized via the nose with OVA. Systemic sensitization resulted in an elevated response to methacholine (MCH) in BALB/cJ and FVB/NJ mice and elevated total and OVA-specific IgE levels and pulmonary eosinophils in all three strains. The mucosal sensitization and challenge produced weaker responses in the same general pattern with the C57BL/6J strain producing less serum IgE, IL5, IL13, and eosinophils in lung fluid than the other two strains. The converse was found for IL6 where the C57BL/6J mice had more than twice the amount of this cytokine. The results show that the FVB/NJ and BALB/cJ mice are higher Th2-responders than the C57BL/6J mice and that the levels of pulmonary eosinophilia and cytokines did not fully track with MCH responsiveness. These differences illustrate the need to assess multiple endpoints to provide clearer associations between immune responses and type and severity of allergic lung disease.
C1 [Gilmour, M. Ian] US EPA, Immunotoxicol Branch, Expt Toxicol Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
[Zhu, Weiyan] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC 27599 USA.
RP Gilmour, MI (reprint author), US EPA, Immunotoxicol Branch, Expt Toxicol Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
EM gilmour.ian@epa.gov
FU CEMALB of UNC-CA [R82952201]
FX We thank Mary Daniels, Elizabeth Boykin James Lehmann and Judy Richards
for their technical assistance. The project described was supported by
CEMALB of UNC-CA through a cooperative agreement with the U. S. EPA
(#R82952201). Its content are solely the responsibility of the authors
and do not necessarily represent the official views of the U. S. EPA.
This paper has been reviewed by the U. S. Environmental Protection
Agency, and approved for publication. Approval does not signify that the
contents necessarily reflect the views and policies of the Agency, nor
does the mention of trade names or commercial products constitute
endorsement or recommendation for use.
NR 31
TC 22
Z9 24
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0093-7711
J9 IMMUNOGENETICS
JI Immunogenetics
PD MAR
PY 2009
VL 61
IS 3
BP 199
EP 207
DI 10.1007/s00251-008-0353-8
PG 9
WC Genetics & Heredity; Immunology
SC Genetics & Heredity; Immunology
GA 415DZ
UT WOS:000263915800004
PM 19224206
ER
PT J
AU Kough, JL
AF Kough, J. L.
TI Safety Assessment of Plant-Incorporated Protectants (PIPs) by the United
States Environmental Protection Agency
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Meeting Abstract
C1 [Kough, J. L.] US EPA, Off Pesticide Programs, Biopesticides & Pollut Protect Div, Washington, DC 20460 USA.
EM Kough.John@EPA.gov
NR 0
TC 0
Z9 0
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-2690
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD SPR
PY 2009
VL 45
BP S5
EP S5
PG 1
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA 481ZS
UT WOS:000268853400013
ER
PT J
AU Winkfield, E
Moyer, M
DeAngelo, A
AF Winkfield, Ernest
Moyer, Mary
DeAngelo, Anthony
TI Immunocytochemistry and Image Analysis of Beta-catenin Redistribution in
Normal Human Colon Cell Cultures Treated with Disinfection By-products.
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Meeting Abstract
C1 [Winkfield, Ernest; DeAngelo, Anthony] US EPA, Natl Hlth & Environ Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Moyer, Mary] INCELL Corp, San Antonio, TX USA.
EM winkfield.ernest@epa.gov; deangelo.anthony@epa.gov
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-2690
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD SPR
PY 2009
VL 45
BP S47
EP S48
PG 2
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA 481ZS
UT WOS:000268853400123
ER
PT J
AU Koutros, S
Lynch, CF
Ma, XM
Lee, WJ
Hoppin, JA
Christensen, CH
Andreotti, G
Freeman, LB
Rusiecki, JA
Hou, LF
Sandler, DP
Alavanja, MCR
AF Koutros, Stella
Lynch, Charles F.
Ma, Xiaomei
Lee, Won Jin
Hoppin, Jane A.
Christensen, Carol H.
Andreotti, Gabriella
Freeman, Laura Beane
Rusiecki, Jennifer A.
Hou, Lifang
Sandler, Dale P.
Alavanja, Michael C. R.
TI Heterocyclic aromatic amine pesticide use and human cancer risk: Results
from the US Agricultural Health Study
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE pesticides; bladder; colon; occupational exposures
ID COLORECTAL-CANCER; BLADDER-CANCER; UNITED-STATES; COLON-CANCER; PHENOXY
HERBICIDES; MEAT INTAKE; LIFE-STYLE; MORTALITY; WORKERS; EXPOSURE
AB Imazethapyr, a heterocyclic aromatic amine, is a widely used crop herbicide first registered for use in the United States in 1989. We evaluated cancer incidence among imazethapyr-exposed pesticide applicators enrolled in the Agricultural Health Study (AHS). The AHS is a prospective cohort of 57,311 licensed pesticide applicators in the U.S., enrolled from 1993-1997. Among the 49,398 licensed pesticide applicators eligible for analysis, 20,646 applicators reported use of imazethapyr and 2,907 incident cancers developed through 2004. Imazethapyr exposure was classified by intensity-weighted lifetime exposure days calculated as [years of use X days per year X intensity level]. Poisson regression analysis was used to evaluate the relationship between imazethapyr exposure and cancer incidence. We found significant trends in risk with increasing lifetime exposure for bladder cancer (p for trend 0.01) and colon cancer (p for trend 0.02). Rate ratios (RRs) were increased by 137% for bladder cancer and 78% for colon cancer when the highest exposed were compared to the nonexposed. The excess risk for colon cancer was limited to proximal cancers, (RR = 2.73, 95% confidence intervals 1.42, 5.25, p for trend 0.001). No association was observed for prostate, lung, rectum, kidney, oral, pancreas, lymphohematopoietic cancers or melanoma. These findings provide new evidence that exposure to aromatic amine pesticides may be an overlooked exposure in the etiology of bladder and colon cancer. The use of imazethapyr and other imidazolinone compounds should continue to be evaluated for potential risk to humans. Published 2008 Wiley-Liss, Inc.
C1 [Koutros, Stella; Andreotti, Gabriella; Freeman, Laura Beane; Alavanja, Michael C. R.] NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20852 USA.
[Lynch, Charles F.] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA USA.
[Ma, Xiaomei] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, Div Environm Hlth, New Haven, CT 06510 USA.
[Lee, Won Jin] Korea Univ, Coll Med, Dept Prevent Med, Seoul 136705, South Korea.
[Hoppin, Jane A.; Sandler, Dale P.] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
[Christensen, Carol H.] US EPA, Toxicol & Epidemiol Branch, Div Hlth Effects, Off Pesticide Programs, Washington, DC 20460 USA.
[Christensen, Carol H.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
[Rusiecki, Jennifer A.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
[Hou, Lifang] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
RP Koutros, S (reprint author), NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, 6120 Execut Blvd,EPS 8000,MSC 7240, Rockville, MD 20852 USA.
EM KoutrosS@mail.nih.gov
RI Beane Freeman, Laura/C-4468-2015;
OI Beane Freeman, Laura/0000-0003-1294-4124; Sandler,
Dale/0000-0002-6776-0018
FU Intramural NIH HHS [Z01 CP010119-12]; NCI NIH HHS [TU2 CA105666, TU2
CA105666-05]
NR 36
TC 44
Z9 48
U1 0
U2 11
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0020-7136
J9 INT J CANCER
JI Int. J. Cancer
PD MAR 1
PY 2009
VL 124
IS 5
BP 1206
EP 1212
DI 10.1002/ijc.24020
PG 7
WC Oncology
SC Oncology
GA 403JC
UT WOS:000263077900027
PM 19058219
ER
PT J
AU Xia, YJ
Wade, TJ
Wu, KG
Li, YH
Ning, ZX
Le, XC
He, XZ
Chen, BF
Feng, Y
Mumford, JL
AF Xia, Yajuan
Wade, Timothy J.
Wu, Kegong
Li, Yanhong
Ning, Zhixiong
Le, X. Chris
He, Xingzhou
Chen, Binfei
Feng, Yong
Mumford, Judy L.
TI Well Water Arsenic Exposure, Arsenic Induced Skin-Lesions and
Self-Reported Morbidity in Inner Mongolia
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE Arsenic; drinking water; Inner Mongolia; hyperkeratosis; skin lesions
ID BLADDER-CANCER MORTALITY; DRINKING-WATER; INDUCED HYPERKERATOSIS;
OXIDATIVE STRESS; NORTHERN CHILE; HEART-DISEASE; ENDEMIC AREA;
WEST-BENGAL; BANGLADESH; RISK
AB Residents of the Bayingnormen region of Inner Mongolia have been exposed to arsenic-contaminated well water for over 20 years, but relatively few studies have investigated health effects in this region. We surveyed one village to document exposure to arsenic and assess the prevalence of arsenic-associated skin lesions and self-reported morbidity. Five-percent (632) of the 12,334 residents surveyed had skin lesions characteristics of arsenic exposure. Skin lesions were strongly associated with well water arsenic and there was an elevated prevalence among residents with water arsenic exposures as low as 5 mu g/L-10 mu g/L. The presence of skin lesions was also associated with self-reported cardiovascular disease.
C1 [Wade, Timothy J.; Mumford, Judy L.] US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
[Xia, Yajuan; Wu, Kegong; Li, Yanhong] Inner Mongolia Ctr Endem Dis Control & Res, Hohhot, Inner Mangolia, Peoples R China.
[Ning, Zhixiong] Ba Men Anti Epidem Stn, Bayingnormen, Inner Mangolia, Peoples R China.
[Le, X. Chris] Univ Alberta, Dept Publ Hlth Sci, Edmonton, AB, Canada.
[He, Xingzhou] Chinese Acad Prevent Med, Inst Environm Hlth & Engn, Beijing, Peoples R China.
[Chen, Binfei] Comp Sci Corp, Res Triangle Pk, NC USA.
[Feng, Yong] Hangjin Hou Ctr Dis Control, Inner Mongolia, Peoples R China.
RP Wade, TJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
EM yajxia@sohu.com; wade.tim@epa.gov; wkg1959@163.com; nmgliyh@163.com;
bsjkxd@163.com; xc.le@ualberta.ca; He2007@188.com; chen.binfei@epa.gov;
Bingyu33@sina.com; mumford.judy@epa.gov
RI Le, X. Chris/O-4947-2015
OI Le, X. Chris/0000-0002-7690-6701
NR 46
TC 17
Z9 20
U1 0
U2 9
PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
PI BASEL
PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR
PY 2009
VL 6
IS 3
BP 1010
EP 1025
DI 10.3390/ijerph6031010
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 451BJ
UT WOS:000266445400013
PM 19440430
ER
PT J
AU Wade, TJ
Xia, YJ
Wu, KG
Li, YH
Ning, ZX
Le, XC
Lu, XF
Feng, Y
He, XZ
Mumford, JL
AF Wade, Timothy J.
Xia, Yajuan
Wu, Kegong
Li, Yanhong
Ning, Zhixiong
Le, X. Chris
Lu, Xiufen
Feng, Yong
He, Xingzhou
Mumford, Judy L.
TI Increased Mortality Associated with Well-Water Arsenic Exposure in Inner
Mongolia, China
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE Arsenic; drinking water; China; Inner Mongolia; mortality; heart
disease; cancer
ID DOSE-RESPONSE RELATIONSHIP; HEART-DISEASE MORTALITY; DRINKING-WATER;
CANCER-MORTALITY; BLADDER-CANCER; MALIGNANT NEOPLASMS; ENDEMIC AREA;
LUNG-CANCER; GROUNDWATER; PREVALENCE
AB We conducted a retrospective mortality study in an Inner Mongolian village exposed to well water contaminated by arsenic since the 1980s. Deaths occurring between January 1, 1997 and December 1, 2004 were classified according to underlying cause and water samples from household wells were tested for total arsenic. Heart disease mortality was associated with arsenic exposure, and the association strengthened with time exposed to the water source. Cancer mortality and all-cause mortality were associated with well-water arsenic exposure among those exposed 10-20 years. This is the first study to document increased arsenic-associated mortality in the Bayingnormen region of Inner Mongolia.
C1 [Wade, Timothy J.; Mumford, Judy L.] US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
[Xia, Yajuan; Wu, Kegong; Li, Yanhong] Inner Mongolia Ctr Endem Dis Control & Res, Hohhot, Inner Mongolia, Peoples R China.
[Ning, Zhixiong] Ba Men Anti Epidem Stn, Bayingnormen, Inner Mongolia, Peoples R China.
[Le, X. Chris; Lu, Xiufen] Univ Alberta, Dept Publ Hlth Sci, Edmonton, AB, Canada.
[Feng, Yong] Hangjin Hou Ctr Dis Control, Hangjin Hou, Inner Mongolia, Peoples R China.
[He, Xingzhou] Chinese Acad Prevent Med, Inst Environm Hlth & Engn, Beijing, Peoples R China.
RP Wade, TJ (reprint author), US EPA, Natl Hlth & Environm Effects Res Lab, Chapel Hill, NC USA.
EM wade.tim@epa.gov; yajxia@sohu.com; wkg1959@163.com; nmgliyh@163.com;
bsjkxd@163.com; xc.le@ualberta.ca; xlu@ualberta.ca; Bingyu33@sina.com;
He_2007@188.com; mumford.judy@epa.gov
RI Le, X. Chris/O-4947-2015
OI Le, X. Chris/0000-0002-7690-6701
NR 43
TC 18
Z9 21
U1 0
U2 15
PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
PI BASEL
PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR
PY 2009
VL 6
IS 3
BP 1107
EP 1123
DI 10.3390/ijerph6031107
PG 17
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 451BJ
UT WOS:000266445400019
PM 19440436
ER
PT J
AU Messner, M
Bauer, J
AF Messner, Mike
Bauer, Jeremy
TI Total Coliform Rule Brain Teaser
SO JOURNAL AMERICAN WATER WORKS ASSOCIATION
LA English
DT Editorial Material
C1 [Messner, Mike; Bauer, Jeremy] US EPA, Off Ground Water & Drinking Water, Washington, DC 20460 USA.
RP Messner, M (reprint author), US EPA, Off Ground Water & Drinking Water, Washington, DC 20460 USA.
EM Messner.Mike@epamail.epa.gov; Bauer.Jeremy@epamail.epa.gov
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER WATER WORKS ASSOC
PI DENVER
PA 6666 W QUINCY AVE, DENVER, CO 80235 USA
SN 0003-150X
J9 J AM WATER WORKS ASS
JI J. Am. Water Work Assoc.
PD MAR
PY 2009
VL 101
IS 3
BP 40
EP 40
PG 1
WC Engineering, Civil; Water Resources
SC Engineering; Water Resources
GA 422YF
UT WOS:000264462900007
ER
PT J
AU Lavelle, K
Olshan, A
Herring, A
Savitz, D
Siega-Riz, AM
Perreault, S
AF Lavelle, Karlene
Olshan, Andrew
Herring, Amy
Savitz, David
Siega-Riz, Anna Maria
Perreault, Sally
TI EFFECTS OF LIFESTYLE EXPOSURES AND BODY MASS INDEX ON SPERM QUALITY
PARAMETERS OF FERTILE MEN
SO JOURNAL OF ANDROLOGY
LA English
DT Meeting Abstract
CT 34th Annual Meeting of the American-Society-of-Andrology
CY APR 04-07, 2009
CL Philadelphia, PA
SP Amer Soc Androl
C1 [Lavelle, Karlene; Olshan, Andrew; Siega-Riz, Anna Maria] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
[Herring, Amy] Univ N Carolina, Sch Publ Hlth, Dept Biostat, Chapel Hill, NC USA.
[Savitz, David] Mt Sinai Sch Med, Epidemiol Biostat & Dis Prevent Inst, New York, NY USA.
[Perreault, Sally] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER SOC ANDROLOGY, INC
PI LAWRENCE
PA C/O ALLEN PRESS, INC PO BOX 368, LAWRENCE, KS 66044 USA
SN 0196-3635
J9 J ANDROL
JI J. Androl.
PD MAR-APR
PY 2009
MA 11
BP 36
EP 37
PG 2
WC Andrology
SC Endocrinology & Metabolism
GA 414FQ
UT WOS:000263849700012
ER
PT J
AU Perobelli, J
Fernandez, C
Toledo, F
Klinefelter, G
Kempinas, W
AF Perobelli, Juliana
Fernandez, Carla
Toledo, Fabiola
Klinefelter, Gary
Kempinas, Wilma
TI PREPUBERTAL ANTIANDROGEN EXPOSURE: IMPAIRMENT OF THE EPIDIDYMAL FUNCTION
IN ADULT RATS
SO JOURNAL OF ANDROLOGY
LA English
DT Meeting Abstract
CT 34th Annual Meeting of the American-Society-of-Andrology
CY APR 04-07, 2009
CL Philadelphia, PA
SP Amer Soc Androl
C1 [Kempinas, Wilma] Sao Paulo State Univ, Inst Biosci, Sao Paulo, Brazil.
[Perobelli, Juliana; Fernandez, Carla; Toledo, Fabiola] Univ Estadual Campinas, Inst Biol, Grad Program Cellular & Struct Biol, Campinas, Brazil.
[Klinefelter, Gary] US EPA, NHEERL, Washington, DC USA.
RI PEROBELLI, JULIANA/D-5722-2012
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC ANDROLOGY, INC
PI LAWRENCE
PA C/O ALLEN PRESS, INC PO BOX 368, LAWRENCE, KS 66044 USA
SN 0196-3635
J9 J ANDROL
JI J. Androl.
PD MAR-APR
PY 2009
MA 66
BP 54
EP 54
PG 1
WC Andrology
SC Endocrinology & Metabolism
GA 414FQ
UT WOS:000263849700067
ER
PT J
AU Holowecky, PM
James, RR
Lorch, DP
Straka, SE
Lindquist, HDA
AF Holowecky, P. M.
James, R. R.
Lorch, D. P.
Straka, S. E.
Lindquist, H. D. A.
TI Evaluation of ultrafiltration cartridges for a water sampling apparatus
SO JOURNAL OF APPLIED MICROBIOLOGY
LA English
DT Article
DE evaluation; microbial concentration; ultrafiltration cartridge; water
sample concentration
ID CRYPTOSPORIDIUM-PARVUM OOCYSTS; HOLLOW-FIBER ULTRAFILTER; SIMULTANEOUS
RECOVERY; BACILLUS-ANTHRACIS; VIRUSES; OPTIMIZATION; MICROBES
AB To determine the efficiency of various ultrafiltration cartridges (UFC) in concentrating test micro-organisms from drinking water.
Replicate drinking water samples from three potable water supplies were dosed with Bacillus anthracis Sterne, Francisella tularensis LVS, Yersinia pestis CO92, bacteriophages MS2 and phi-X174, and Cryptosporidium parvum. The test micro-organisms were dosed together in 100 l of water, which was then recirculated through one of five different UFC until the retentate volume was reduced to c. 500 ml. The micro-organisms were assayed before and after ultrafiltration concentration and per cent recoveries were calculated. There were nine statistically significant differences among pairs of filters out of a possible 180 different combinations of UFC, test micro-organisms, and water types.
No filter consistently performed better or worse than the others for each test micro-organism in all water samples tested.
This study provides performance data on the ability of several different UFC to concentrate a panel of test micro-organisms from three sources of potable water. Water utilities and first responders may use these data when selecting UFC for use in emergency response protocols. This study also provides additional data as to the efficacy of ultrafiltration for recovering bacteria, virus-like particles, and protozoan oocysts from water samples.
C1 [Holowecky, P. M.; James, R. R.; Lorch, D. P.; Straka, S. E.] Battelle Mem Inst, Columbus, OH 43201 USA.
[Lindquist, H. D. A.] US EPA, Natl Homeland Secur Res Ctr, Cincinnati, OH 45268 USA.
RP Holowecky, PM (reprint author), Battelle Mem Inst, 505 King Ave, Columbus, OH 43201 USA.
EM holoweckyp@battelle.org
FU US Environmental Protection Agency
FX This study was undertaken as a part of the Technology Testing and
Evaluation Program (TTEP) and was funded by the US Environmental
Protection Agency. The authors would like to thank Vincent Hill of the
US Centers for Disease Control and Prevention and Kevin Oshima of the US
EPA for their assistance during this study as well as Minntech
Corporation, Fresenius Medical, and Baxter Corporation for donation of
their UFC.
NR 18
TC 18
Z9 18
U1 1
U2 12
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1364-5072
J9 J APPL MICROBIOL
JI J. Appl. Microbiol.
PD MAR
PY 2009
VL 106
IS 3
BP 738
EP 747
DI 10.1111/j.1365-2672.2008.04019.x
PG 10
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 405TK
UT WOS:000263246900003
PM 19191977
ER
PT J
AU Leif, RC
Yang, S
Jin, DY
Piper, J
Vallarino, LM
Williams, JW
Zucker, RM
AF Leif, Robert C.
Yang, Sean
Jin, Dayong
Piper, James
Vallarino, Lidia M.
Williams, John W.
Zucker, Robert M.
TI Calibration beads containing luminescent lanthanide ion complexes
SO JOURNAL OF BIOMEDICAL OPTICS
LA English
DT Article
DE luminescence; beads; lanthanide; europium; digital microscopy; standard;
spectra; time delayed
ID SPECTRAL IMAGING-SYSTEMS; CONFOCAL MICROSCOPY; FLOW-CYTOMETRY;
PERFORMANCE
AB The reliability of lanthanide luminescence measurements, by both flow cytometry and digital microscopy, would be enhanced by the availability of narrowband emitting, UV excited lanthanide calibration beads. 0.5-, 3-, and 5-mu m beads containing a luminescent europium-complex are manufactured. The luminescence distribution of the 5-mu m beads is measured with a time-delayed light-scatter-gated luminescence flow cytometer to have a 7.0% coefficient of variation (CV) The spacial distribution of the europium-complex in individual beads is determined to be homogeneous by confocal microscopy. Emission peaks are found at 592, 616 (width 9.9 nm), and 685 nm with a PARISS spectrophotometer. The kinetics of the luminescence bleaching caused by UV irradiation of the 0.5- and 5-mu m beads measured under LED excitation with a fluorescence microscope indicate that bleaching does not interfere with their imaging. The luminescence lifetimes in water and air were 340 and 460 mu s, respectively. Thus, these 5-mu m beads can be used for spectral calibration of microscopes equipped with a spectrograph, as test particles for time-delayed luminescence flow cytometers, and possibly as labels for macromolecules and cells. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3103646]
C1 [Leif, Robert C.] Newport Instruments, R&D, San Diego, CA 92115 USA.
[Jin, Dayong; Piper, James] Macquarie Univ, Ctr Lasers & Applicat, N Ryde, NSW 2109, Australia.
[Vallarino, Lidia M.; Williams, John W.] Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA.
[Zucker, Robert M.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Lab, Reprod Toxicol Div, Res Triangle Pk, NC 27711 USA.
RP Leif, RC (reprint author), Newport Instruments, R&D, 5648 Toyon Rd, San Diego, CA 92115 USA.
EM rleif@rleif.com
RI Jin, Dayong/D-9652-2011
OI Jin, Dayong/0000-0003-1046-2666
FU National Natural Science Foundation of China [20575069]; (International
Society for Analytical Cytology) scholar program; Australian ARC/NHMRC
FABLS (Fluorescence Applications in Biotechnology and Life Sciences)
network
FX The authors wish to acknowledge the Australian ARC/NHMRC FABLS
(Fluorescence Applications in Biotechnology and Life Sciences) network
for a seeding project fund to support emerging new technology, the ISAC
(International Society for Analytical Cytology) scholar program, the
National Natural Science Foundation of China (number 20575069), Newport
Instruments' Internal Development Funds, and Lidia Vallarino's Gift
Fund. Robert C. Leif and Sean Yang are employees of Newport Instruments,
which is the supplier of the Fire-Red T beads. This work has been
reviewed and approved for publication as an EPA document. Approval does
not necessarily signify that the contents reflect the views and policies
of the agency, nor does mention of trade names or commercial products
constitute endorsement or recommendation for use.
NR 14
TC 14
Z9 14
U1 2
U2 7
PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 1083-3668
J9 J BIOMED OPT
JI J. Biomed. Opt.
PD MAR-APR
PY 2009
VL 14
IS 2
AR 024022
DI 10.1117/1.3103646
PG 7
WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine &
Medical Imaging
SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine &
Medical Imaging
GA 456SM
UT WOS:000266868500046
PM 19405752
ER
PT J
AU Brouhle, K
Griffiths, C
Wolverton, A
AF Brouhle, Keith
Griffiths, Charles
Wolverton, Ann
TI Evaluating the role of EPA policy levers: An examination of a voluntary
program and regulatory threat in the metal-finishing industry
SO JOURNAL OF ENVIRONMENTAL ECONOMICS AND MANAGEMENT
LA English
DT Article
DE Voluntary programs; Pollution control; Regulatory threat; Policy
evaluation
ID ENVIRONMENTAL PERFORMANCE; SELF-REGULATION; INCENTIVES; AGREEMENTS;
MARKET; FIRMS; PARTICIPATION; PROTECTION; STANDARDS; POLLUTION
AB In this paper, we evaluate the influence of two environmental policy levers on emissions in the metal-finishing industry: a voluntary program-the Strategic Goals Program (SGP)-and the threat of formal regulation. While voluntary approaches are increasingly utilized as policy tools, the effectiveness of such programs is often questioned, and the impact of a voluntary program in tandem with a regulatory threat is not well understood. We examine the decision to participate in the SGP and, conditional on that decision, determine the effects that the SGP and regulatory threat had on facility emissions behavior. Participation in the program appears related to several forms of external pressure: the regulatory threat, industry trade association membership, the level of environmental giving in a state, and a number of neighborhood characteristics. However, over the entire study period, participation in the SGP yielded little, if any, additional reductions in emissions, while the regulatory threat is correlated with significant emission reductions by both participants and non-participants. Splitting our study period into two time periods reveals a more nuanced relationship between SGP participation and emissions behavior than is evident over the entire study period. While participants do not appear to take advantage of the program initially, they make greater strides in reducing emissions than non-participants in later years. The split sample results also indicate that both participants and non-participants react strongly to the initial threat of regulation and to an increase in its relative stringency. (c) 2008 Elsevier Inc. All rights reserved.
C1 [Brouhle, Keith] Grinnell Coll, Dept Econ, Grinnell, IA 50112 USA.
[Griffiths, Charles; Wolverton, Ann] US EPA, Washington, DC USA.
RP Brouhle, K (reprint author), Grinnell Coll, Dept Econ, 1210 Pk St, Grinnell, IA 50112 USA.
EM brouhlek@grinnell.edu
NR 38
TC 27
Z9 28
U1 0
U2 16
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0095-0696
J9 J ENVIRON ECON MANAG
JI J.Environ.Econ.Manage.
PD MAR
PY 2009
VL 57
IS 2
BP 166
EP 181
DI 10.1016/j.jeem.2008.07.006
PG 16
WC Business; Economics; Environmental Studies
SC Business & Economics; Environmental Sciences & Ecology
GA 429FU
UT WOS:000264907100004
ER
PT J
AU Jennings, S
AF Jennings, Susan
TI Community Engagement - Overcoming Challenges
SO JOURNAL OF ENVIRONMENTAL HEALTH
LA English
DT Editorial Material
C1 US EPA, Off Pesticide Programs, Washington, DC USA.
RP Jennings, S (reprint author), US EPA, Off Pesticide Programs, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATL ENVIRON HEALTH ASSOC
PI DENVER
PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA
SN 0022-0892
J9 J ENVIRON HEALTH
JI J. Environ. Health
PD MAR
PY 2009
VL 71
IS 7
BP 36
EP 37
PG 2
WC Environmental Sciences; Public, Environmental & Occupational Health
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health
GA 411CT
UT WOS:000263626300006
PM 19326668
ER
PT J
AU Lorber, M
AF Lorber, Matthew
TI Use of a simple pharmacokinetic model to characterize exposure to
perchlorate
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE perchlorate; exposure modeling; pharmacokinetic modeling
ID LOW-DOSE PERCHLORATE; THYROID-FUNCTION; IODIDE UPTAKE; BREAST-MILK;
INHIBITION; KINETICS; HUMANS; CHROMATOGRAPHY; CREATININE; AMERICANS
AB A simple two-compartment first-order pharmacokinetic model that predicts concentrations of perchlorate in blood and urine was constructed and validated. The model was validated using data from a high-dose experiment in humans where doses and resulting concentrations of perchlorate in blood and urine were well documented. Specifically, data were available for individuals who had been dosed at 0.5, 0.1, and 0.02mg/kg/day for 14 consecutive days, significantly higher than the average background dose, which is estimated to be less than 0.0001mg/kg/day. The average measured urine concentration in the high-dose regime during the experiment was 15.4mg/l compared with an average prediction of 17.3mg/l. In the medium-dose regime, the average measured was 3.0mg/l compared with 4.1mg/l predicted, and in the low-dose regime, the average measured was 0.53mg/l compared with 0.68mg/l predicted. For blood, the analogous results include 0.51mg/l measured compared with 0.54mg/l predicted in the high-dose regime and 0.12mg/l measured versus 0.11mg/l predicted in the medium-dose regime. The model was then used to study background exposures to perchlorate. A national sampling of perchlorate in urine showed a median concentration of 0.0035mg/l, and this was used to back-calculate a dose of 0.000064mg/kg/ day. This finding was independently verified with the modeling structure of this study, as use of that back-calculated dose of 0.000064mg/kg/day resulted in predictions of urine concentration with an average virtually identical at 0.0033mg/l. An examination of literature data on the possible pathways of exposure suggests that the consumption of foods, rather than ingestion of water, dominates background exposures. Daily variation in urine concentration was studied with the model, and it was found that concentrations in the morning hours were lower than concentrations in the afternoon and evening hours, corresponding to the time when most exposure was assumed to occur. Journal of Exposure Science and Environmental Epidemiology (2009) 19, 260 -273; doi: 10.1038/jes. 2008.8; published online 16 April 2008
C1 US EPA, Off Res & Dev, NCEA 8623N, Washington, DC 20460 USA.
RP Lorber, M (reprint author), US EPA, Off Res & Dev, NCEA 8623N, 1200 Penn Ave NW, Washington, DC 20460 USA.
EM Lorber.matthew@epa.gov
NR 29
TC 10
Z9 10
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD MAR
PY 2009
VL 19
IS 3
BP 260
EP 273
DI 10.1038/jes.2008.8
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 408TJ
UT WOS:000263457600003
PM 18414513
ER
PT J
AU Mosquin, PL
Licata, AC
Liu, B
Sumner, SCJ
Okino, MS
AF Mosquin, Paul L.
Licata, Amy Collins
Liu, Bing
Sumner, Susan C. J.
Okino, Miles S.
TI Reconstructing exposures from small samples using physiologically based
pharmacokinetic models and multiple biomarkers
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE biomarkers; PBPK model; exposure reconstruction
ID PHARMACODYNAMIC PBPK/PD MODEL; ORGANOPHOSPHORUS PESTICIDES; BREATH
CONCENTRATIONS; PRESCHOOL-CHILDREN; BIOMONITORING DATA; CHLORPYRIFOS;
POPULATION; METABOLITES; VARIABILITY; VOLUNTEERS
AB This study examines the use of physiologically based pharmacokinetic (PBPK) models for inferring exposure when the number of biomarker observations per individual is limited, as commonly occurs in population exposure surveys. The trade-off between sampling multiple biomarkers at a specific time versus fewer biomarkers at multiple time points was investigated, using a simulation-based approach based on a revised and updated chlorpyrifos PBPK model originally published. Two routes of exposure, oral and dermal, were studied as were varying levels of analytic measurement error. It is found that adding an additional biomarker at a given time point adds substantial additional information to the analysis, although not as much as the addition of another sampling time. Furthermore, the precision of the estimates of exposed dose scaled approximately with the analytic precision of the biomarker measurement. For acute exposure scenarios such as those considered here, the results of this study suggest that the number of biomarkers can be balanced against the number of sampling times to obtain the most efficient estimator after consideration of cost, intrusiveness, and other relevant factors. Journal of Exposure Science and Environmental Epidemiology (2009) 19, 284-297; doi: 10.1038/jes. 2008.17; published online 7 May 2008
C1 [Okino, Miles S.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Las Vegas, NV 89119 USA.
[Mosquin, Paul L.; Licata, Amy Collins; Liu, Bing; Sumner, Susan C. J.] RTI Int, Res Triangle Pk, NC USA.
RP Okino, MS (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Las Vegas, NV 89119 USA.
EM okino.miles@epa.gov
OI Mosquin, Paul/0000-0001-9101-5977
NR 39
TC 10
Z9 10
U1 0
U2 12
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1559-0631
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD MAR
PY 2009
VL 19
IS 3
BP 284
EP 297
DI 10.1038/jes.2008.17
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 408TJ
UT WOS:000263457600005
PM 18461092
ER
PT J
AU Devney, CA
Kondrad, SL
Stebbins, KR
Brittingham, KD
Hoffman, DJ
Heinz, GH
AF Devney, Carol A.
Kondrad, Shannon L.
Stebbins, Katherine R.
Brittingham, Kevin D.
Hoffman, David J.
Heinz, Gary H.
TI A saltwater flotation technique to identify unincubated eggs
SO JOURNAL OF FIELD ORNITHOLOGY
LA English
DT Article
DE aging eggs; egg flotation; embryonic development; incubation stage;
saltwater flotation
ID INCUBATION STAGE; AGE; DATE; NESTS
AB Field studies on nesting birds sometimes involve questions related to nest initiation dates, length of the incubation period, or changes in parental incubation behavior during various stages of incubation. Some of this information can be best assessed when a nest is discovered before the eggs have undergone any incubation, and this has traditionally been assessed by floating eggs in freshwater. However, because the freshwater method is not particularly accurate in identifying unincubated eggs, we developed a more reliable saltwater flotation method. The saltwater method involves diluting a saturated saltwater solution with freshwater until a salt concentration is reached where unincubated eggs sink to the bottom and incubated eggs float to the surface. For Laughing Gulls (Leucophaeus atricilla), floating eggs in freshwater failed to identify 39.0% (N = 251) of eggs that were subsequently found by candling to have undergone incubation prior to collection. By contrast, in a separate collection of gull eggs, no eggs that passed the saltwater test (N = 225) were found by a later candling to have been incubated prior to collection. For Double-crested Cormorants (Phalacrocorax auritus), floating eggs in freshwater failed to identify 15.6% (N = 250) of eggs that had undergone incubation prior to collection, whereas in a separate collection, none of the eggs that passed the saltwater test (N = 85) were found by a later candling to have been incubated prior to collection. Immersion of eggs in saltwater did not affect embryo survival. Although use of the saltwater method is likely limited to colonial species and requires calibrating a saltwater solution, it is a faster and more accurate method of identifying unincubated eggs than the traditional method of floating eggs in freshwater.
C1 [Devney, Carol A.; Kondrad, Shannon L.; Stebbins, Katherine R.; Brittingham, Kevin D.; Hoffman, David J.; Heinz, Gary H.] US Geol Survey, Patuxent Wildlife Res Ctr, Beltsville, MD 20705 USA.
[Devney, Carol A.] James Cook Univ, Sch Marine & Trop Biol, Australian Inst Marine Sci, AIMS JCU, Cairns, Qld 4870, Australia.
[Kondrad, Shannon L.] USDA ARS, Beltsville, MD 20705 USA.
[Stebbins, Katherine R.] US EPA, Arlington, VA 22202 USA.
[Brittingham, Kevin D.] Baltimore Cty Dept Environm Protect & Resource Ma, Baltimore, MD 21204 USA.
RP Devney, CA (reprint author), US Geol Survey, Patuxent Wildlife Res Ctr, 10300 Baltimore Ave, Beltsville, MD 20705 USA.
EM carol.devney@jcu.edu.au
FU CALFED Bay-Delta Program's Ecosystem Restoration Program [ERP-02D-C12]
FX This research was funded by the CALFED Bay-Delta Program's Ecosystem
Restoration Program (grant number ERP-02D-C12) with additional support
from the USGS Patuxent Wildlife Research Center. We thank P. Spitzer and
M. Hoffman for helping collect eggs in the field, and J. Klimstra for
reviewing an earlier draft of this manuscript.
NR 21
TC 1
Z9 1
U1 0
U2 2
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0273-8570
J9 J FIELD ORNITHOL
JI J. Field Ornithol.
PD MAR
PY 2009
VL 80
IS 1
BP 88
EP 93
DI 10.1111/j.1557-9263.2009.00208.x
PG 6
WC Ornithology
SC Zoology
GA 410TS
UT WOS:000263601800010
ER
PT J
AU Zhang, XM
Rygwelski, KR
Rossmann, R
AF Zhang, Xiaomi
Rygwelski, Kenneth R.
Rossmann, Ronald
TI The Lake Michigan contaminant transport and fate model, LM2-toxic:
Development, overview, and application
SO JOURNAL OF GREAT LAKES RESEARCH
LA English
DT Article
DE Lake Michigan; Fate and transport model; PCBs; Organic carbon;
Multimedia interaction; Forecast
ID GREAT-LAKES; MASS-BALANCE; POLYCHLORINATED BIPHENYL;
TEMPERATURE-DEPENDENCE; PCB CONCENTRATIONS; ATMOSPHERIC PCBS; SPATIAL
TRENDS; AIR; VARIABILITY; DEPOSITION
AB The Lake Michigan contaminant transport and fate model LM2-Toxic was developed to gain a better understanding of PCB cycling dynamics and to predict environmental exposure concentrations of 54 polychlorinated biphenyl (PCB) congeners in Lake Michigan water and sediment from 1994 to 2055 as a function of a variety of forcing functions including constant conditions, continued recovery forecasts, and load reduction scenarios. LM2-Toxic couples the organic carbon sorbent and chemical dynamics conceptualized for a natural water system. Based on 1994-1995 model results, a mass budget analysis showed that air-water exchange was the most important mass transfer process. Volatilization was the largest PCB loss and gas absorption was the largest PCB input to Lake Michigan. Model-predicted environmental exposure concentrations suggest that the water quality criterion for protection of wildlife (0.074 ng/L) and human health (0.026 ng/L) will be attained in approximately 2018 and 2045, respectively, based on a slow recovery scenario. For this scenario, atmospheric components, including vapor phase concentration and wet and dry particulate loadings, were assumed to decline with a 20 year half-life, and tributary loadings were assumed to decline with a 13 year half-life. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Zhang, Xiaomi] Z Tech, Large Lakes Res Stn, Grosse Ile, MI 48138 USA.
[Rygwelski, Kenneth R.; Rossmann, Ronald] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab,Large Lakes, Mid Continent Ecol Div,Large Lakes & Rivers Forec, Grosse Ile, MI 48138 USA.
RP Zhang, XM (reprint author), Z Tech, Large Lakes Res Stn, 9311 Groh Rd, Grosse Ile, MI 48138 USA.
EM zhang.xiaomi@epa.gov; rygwelski.kenneth@epa.gov; rossmann.ronald@epa.gov
FU U.S. Environmental Protection Agency
FX The information in this document has been funded wholly by the U.S.
Environmental Protection Agency. It has been subjected to review by the
National Health and Environmental Effects Research Laboratory and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
Special thanks to staff at GLNPO and the Large Lake Research Station,
Grosse Ile, Michigan for general support and technical direction.
NR 37
TC 5
Z9 5
U1 0
U2 14
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0380-1330
J9 J GREAT LAKES RES
JI J. Gt. Lakes Res.
PD MAR
PY 2009
VL 35
IS 1
BP 128
EP 136
DI 10.1016/j.jglr.2008.11.008
PG 9
WC Environmental Sciences; Limnology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 432TU
UT WOS:000265157900015
ER
PT J
AU Saha, RN
Dudek, SM
Pahan, K
AF Saha, R. N.
Dudek, S. M.
Pahan, K.
TI TNF-ALPHA PRECONDITIONING PROTECTS NEURONS VIA NEURON-SPECIFIC
UPREGULATION OF CREB-BINDING PROTEIN
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
CT 40th Annual Meeting of the American-Society-for-Neurochemistry
CY MAR 07-11, 2009
CL Charleston, SC
SP Amer Soc Neurochem
C1 [Saha, R. N.; Pahan, K.] Rush Univ, Med Ctr, Chicago, IL 60612 USA.
[Dudek, S. M.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0022-3042
J9 J NEUROCHEM
JI J. Neurochem.
PD MAR
PY 2009
VL 108
BP 67
EP 67
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 407AU
UT WOS:000263336800141
ER
PT J
AU Harry, GJ
Funk, J
Kraft, A
AF Harry, G. J.
Funk, J.
Kraft, A.
TI CONTRIBUTION OF IL-6 IN EXERCISE INDUCED NEUROPROTECTION
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Meeting Abstract
CT 40th Annual Meeting of the American-Society-for-Neurochemistry
CY MAR 07-11, 2009
CL Charleston, SC
SP Amer Soc Neurochem
C1 [Harry, G. J.; Funk, J.; Kraft, A.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
[Funk, J.] Univ S Carolina, Charleston, SC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0022-3042
J9 J NEUROCHEM
JI J. Neurochem.
PD MAR
PY 2009
VL 108
BP 93
EP 93
PG 1
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 407AU
UT WOS:000263336800205
ER
PT J
AU Angradi, TR
Bolgrien, DW
Jicha, TM
Pearson, MS
Taylor, DL
Hill, BH
AF Angradi, Ted R.
Bolgrien, David W.
Jicha, Terri M.
Pearson, Mark S.
Taylor, Debra L.
Hill, Brian H.
TI Multispatial-scale variation in benthic and snag-surface
macroinvertebrate assemblages in mid-continent US great rivers
SO JOURNAL OF THE NORTH AMERICAN BENTHOLOGICAL SOCIETY
LA English
DT Article
DE great rivers; Mississippi River; Missouri River; Ohio River; wood;
snags; benthos; macroinvertebrates; filterers; longitudinal patterns
ID UPPER MISSISSIPPI RIVER; UPPER MISSOURI RIVER; LARGE WOODY DEBRIS; OHIO
RIVER; SAMPLING METHODS; NORTH-DAKOTA; HABITAT; DYNAMICS; STREAMS;
SYSTEM
AB We sampled macroinvertebrate assemblages in the littoral benthos and on the surface of snags in the Upper Mississippi, Missouri, and Ohio rivers. Snag assemblages differed from benthic assemblages. Tubificids, Caenis, Tanytarsus, Cryptochironomus, Limnodrilus, and Chironomini were consistently more abundant in the benthos; Nais, Cricotopus/Orthocladius, Nematoda, and Rheotanytarsus were consistently more abundant on snags. Filterers were more abundant and gatherers were less abundant on snags than in the benthos. Snag assemblages differed among rivers and among reaches within rivers. Variation among reaches was the result of direct and indirect effects of high-dam reservoir impoundments (upper vs lower Missouri River) and low-dam impoundment for navigation (impounded vs free-flowing Upper Mississippi River). The maximum relative abundance of filterers; in the lower Missouri River, which was the only long unregulated reach we studied, was related to particulate organic C and sestonic chlorophyll a concentration, which increased with distance downriver from the lowest main-stem dam. Snag diameter, snag-surface characteristics, and water depth did not affect the composition of snag assemblages, but the dominant taxa on snags in fast-velocity locations were different from the dominant taxa on snags in slow-velocity locations. Relatively few taxa showed strong longitudinal patterns in relative abundance within a reach, and only on the Missouri River. We hypothesize that the many navigation dams on the Ohio and Upper Mississippi rivers suppress the development of environmental gradients and inhibit the formation of longitudinal patterns in macroinvertebrate assemblages. Snag assemblages were dominated by a few taxa (genus-level and higher), a characteristic that might constrain the sensitivity of the assemblages to some human impacts. Sampling snag assemblages has potential for great-river bioassessment, but further research is necessary on sampling methods and sensitivity of assemblages to stressors.
C1 [Angradi, Ted R.; Bolgrien, David W.; Jicha, Terri M.; Pearson, Mark S.; Taylor, Debra L.; Hill, Brian H.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Duluth, MN 55804 USA.
RP Angradi, TR (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA.
EM angradi.theodore@epa.gov; bolgrien.david@epa.gov; jicha.terri@epa.gov;
pearson.mark@epa.gov; taylor.debra@epa.gov; hill.brian@epa.gov
RI Hill, Brian/E-6799-2013
FU US Environmental Protection Agency
FX We are grateful to Kevin Stroom, Grace Kilbane, John Sandberg, Igor
Grigorovich, and Kurt Schmude for identifying the organisms collected
for this study. We are indebted to the US Geological Survey, state, and
contract personnel who collected the data in the field. We thank Marlys
Cappaert (CSC Corporation, Corvallis, Oregon) and data team for database
support, and the staff of CSC Corporation (Duluth, Minnesota) for the
map. Comments by Arthur Benke, Annett Trebitz, Jennifer Sauer, MaryAnn
Starus, and Pamela Silver improved the paper. The information in this
document has been funded wholly by the US Environmental Protection
Agency. It has been subjected to review by the National Health and
Environmental Effects Research Laboratory and approved for publication.
Approval does not signify that its contents reflect the views of the
agency, nor does mention of trade names or commercial products
constitute endorsement or recommendation for use.
NR 59
TC 18
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U1 0
U2 10
PU NORTH AMER BENTHOLOGICAL SOC
PI LAWRENCE
PA 1041 NEW HAMSPHIRE STREET, LAWRENCE, KS 66044 USA
SN 0887-3593
J9 J N AM BENTHOL SOC
JI J. N. Am. Benthol. Soc.
PD MAR
PY 2009
VL 28
IS 1
BP 122
EP 141
DI 10.1899/07-149.1
PG 20
WC Ecology; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 409BN
UT WOS:000263481300012
ER
PT J
AU Brinkman, NE
Fout, GS
AF Brinkman, Nichole E.
Fout, G. Shay
TI Development and evaluation of a generic tag array to detect and genotype
noroviruses in water
SO JOURNAL OF VIROLOGICAL METHODS
LA English
DT Article
DE Norovirus; Generic microarray; Environmental detection
ID REVERSE TRANSCRIPTION-PCR; NORWALK-LIKE VIRUSES; UNITED-STATES;
GASTROENTERITIS; OUTBREAKS; GROUNDWATER; CULTURE; TRENDS
AB Noroviruses are the leading cause of nonbacterial gastroenteritis outbreaks in the United States, some of which are caused by the ingestion of contaminated water. Detection and genotypic characterization of noroviruses is commonly performed by reverse transcription-polymerase chain reaction (RT-PCR) followed by sequencing. However, sequencing of products amplified from environmental water samples is often hindered by the co-amplification of non-specific cDNA. To overcome this issue, a generic microarray was evaluated to genotype noroviruses by probe hybridization. RT-PCR amplicons are used in a single base extension (SBE) reaction where genotype-specific probes are labeled and then hybridized to an Affymetrix GeneChip (R) GenFlex (TM) Tag Array for detection. Using a standardized, multiplex SBE reaction, genotyping of representative strains was accomplished through the identification of genotype-specific patterns of positive hybridization results. Furthermore, the SBE-GenFlex array method was successful in the genotype identification of noroviruses seeded into tap and Ohio River water samples. This study shows the utility of using a microarray to genotype noroviruses in complex environmental matrices. Published by Elsevier B.V.
C1 [Brinkman, Nichole E.; Fout, G. Shay] US EPA, Off Res & Dev, Natl Exposure Res Lab, Biohazard Assessment Res Branch, Cincinnati, OH 45268 USA.
RP Brinkman, NE (reprint author), US EPA, Off Res & Dev, Natl Exposure Res Lab, Biohazard Assessment Res Branch, 26 W Martin Luther King Dr,MS320, Cincinnati, OH 45268 USA.
EM brinkman.nichole@epa.gov
NR 22
TC 10
Z9 10
U1 1
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-0934
J9 J VIROL METHODS
JI J. Virol. Methods
PD MAR
PY 2009
VL 156
IS 1-2
BP 8
EP 18
DI 10.1016/j.jviromet.2008.03.010
PG 11
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Virology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Virology
GA 420ZX
UT WOS:000264328800002
PM 18471900
ER
PT J
AU Boehm, AB
Ashbolt, NJ
Colford, JM
Dunbar, LE
Fleming, LE
Gold, MA
Hansel, JA
Hunter, PR
Ichida, AM
Mcgee, CD
Soller, JA
Weisberg, SB
AF Boehm, Alexandria B.
Ashbolt, Nicholas J.
Colford, John M., Jr.
Dunbar, Lee E.
Fleming, Lora E.
Gold, Mark A.
Hansel, Joel A.
Hunter, Paul R.
Ichida, Audrey M.
Mcgee, Charles D.
Soller, Jeffrey A.
Weisberg, Stephen B.
TI A sea change ahead for recreational water quality criteria
SO JOURNAL OF WATER AND HEALTH
LA English
DT Article
DE epidemiology; indicators; pathogens; risk; swimming; water criteria
ID POLYMERASE-CHAIN-REACTION; ESCHERICHIA-COLI; LAKE-MICHIGAN; FRESH-WATER;
DISCRIMINANT-ANALYSIS; SOUTHERN CALIFORNIA; FECAL CONTAMINATION;
HUNTINGTON-BEACH; SOURCE TRACKING; COASTAL WATERS
AB The United States Environmental Protection Agency is committed to developing new recreational water quality criteria for coastal waters by 2012 to provide increased protection to swimmers. We review the uncertainties and shortcomings of the current recreational water quality criteria, describe critical research needs for the development of new criteria, as well as recommend a path forward for new criteria development. We believe that among the most needed research needs are the completion of epidemiology studies in tropical waters and in waters adversely impacted by urban runoff and animal feces, as well as studies aimed to validate the use of models for indicator and pathogen concentration and health risk predictions.
C1 [Boehm, Alexandria B.] Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA.
[Ashbolt, Nicholas J.] US EPA, Natl Exposure Res Lab, Off Res & Dev, Cincinnati, OH 45268 USA.
[Colford, John M., Jr.] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, Berkeley, CA 94720 USA.
[Dunbar, Lee E.] Connecticut Dept Environm Protect, Hartford, CT USA.
[Fleming, Lora E.] NSF NIEHS Oceans & Human Hlth Ctr, Miller Sch Med, Dept Epidemiol & Publ Hlth, Miami, FL USA.
[Fleming, Lora E.] NSF NIEHS Oceans & Human Hlth Ctr, Miller Sch Med, Dept Fisheries & Marine Biol, Miami, FL USA.
[Fleming, Lora E.] NSF NIEHS Oceans & Human Hlth Ctr, Rosenstiel Sch Marine & Atmospher Sci, Miami, FL USA.
[Gold, Mark A.] Heal Bay, Monica, CA USA.
[Hansel, Joel A.] US EPA, Atlanta, GA USA.
[Hunter, Paul R.] Univ E Anglia, Sch Med, Anglia, England.
[Ichida, Audrey M.] ICF Int, Fairfax, VA USA.
[Mcgee, Charles D.] Orange Cty Sanitat Dist, Fountain Valley, CA USA.
[Soller, Jeffrey A.] Soller Environm, Berkeley, CA USA.
[Weisberg, Stephen B.] So Calif Coastal Water Res Project, Costa Mesa, CA USA.
RP Boehm, AB (reprint author), Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA.
EM aboehm@stanford.edu
RI Hunter, Paul/A-7172-2008; Weisberg, Stephen/B-2477-2008
OI Hunter, Paul/0000-0002-5608-6144; Weisberg, Stephen/0000-0002-0655-9425
FU NIEHS [P50 ES12736]; NSF [OCE0432368]; NIH [1 R01 ES013519]; NOAA Oceans
and Human Health [NA04OAR4600195]
FX The authors acknowledge the USEPA Office of Water, Office of Science and
Technology (OST, Health and Ecological Criteria Division (HECD) and
Standards and Health Protection Division (SHPD)) and Office of Research
and Development (ORD) for organizing and hosting the Experts Scientific
Workshop on Critical Research Needs for the Development of New or
Revised Recreational Water Quality Criteria. Thanks to Denise Keehner
(workshop chairperson, SHPD), Ephraim King (OST), Suzanne Rudzinski
(OST), and Kevin Teichman (ORD) for their attention and commitment to
furthering both the science and the policy that support the development
of criteria. Members of the USEPA workshop organizing committee, S.
Barash, R. Calderon, E. Doyle, A. Dufour, S. Fontenelle, P. Harrigan, R.
Hoffmann, B. Leamond, C. Noss, K. Oshima, J. Ravenscroft, G. Robiou, C.
Roberts, S. Schaub, T. Wade, J. Wathen and L. Wisniewski, are also
acknowledged. LEF acknowledges funding in part from grants from NIEHS
(P50 ES12736) and NSF (OCE0432368). JMC was supported by grant NIH 1 R01
ES013519. ABB was supported by NOAA Oceans and Human Health Grant
NA04OAR4600195 and acknowledges Sharyl Rabinovici who inspired some of
the ideas presented in this paper. The views expressed in this paper are
not necessarily those of the US EPA.
NR 67
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U2 32
PU IWA PUBLISHING
PI LONDON
PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND
SN 1477-8920
J9 J WATER HEALTH
JI J. Water Health
PD MAR
PY 2009
VL 7
IS 1
BP 9
EP 20
DI 10.2166/wh.2009.122
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health;
Microbiology; Water Resources
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Microbiology; Water Resources
GA 417CM
UT WOS:000264052900002
PM 18957771
ER
PT J
AU Moyes, H
Awe, JJ
Brook, GA
Webster, JW
AF Moyes, Holley
Awe, Jaime J.
Brook, George A.
Webster, James W.
TI THE ANCIENT MAYA DROUGHT CULT: LATE CLASSIC CAVE USE IN BELIZE
SO LATIN AMERICAN ANTIQUITY
LA English
DT Review
ID ENVIRONMENTAL-CHANGE; COLLAPSE; CIVILIZATION; LOWLANDS; CLIMATE;
ROCKSHELTERS; ARCHEOLOGY; GUATEMALA; PETEN
AB Caves were, used as ritual venues by the ancient Maya from the Early Preclassic to the Postclassic period. These sites have been intensively investigated, but little research has been devoted to changes in cave use over time. Work at Chechem Ha Cave in western Belize investigates transformations in ritual practice occurring between the Early and Late Classic periods using an explanatory framework that incorporates high-definition archaeological research with a paleoclimate reconstruction derived from speleothems. This is one of the first projects to directly link these data to the archaeological record. Me also introduce new methodology to evaluate changes in ritual practice using use-intensity proxies and artifact patterning. These data demonstrate that Late Classic transformations were coeval with climatic drying. The phenomenon was identified in this case study, and the pattern is prevalent throughout the eastern lowlands suggesting that an ancient Maya drought cult,vas initiated at this time. We provide the first evidence that there was a failed ritual response to environmental stress, implying that a loss of faith in Maya rulership contributed to the downfall of political systems. This is an important finding for collapse theories that include ideological causations.
C1 [Moyes, Holley] Univ Arizona, Dept Anthropol, Tucson, AZ 85745 USA.
[Awe, Jaime J.] Belize Inst Archaeol, Belmopan, Belize.
[Brook, George A.] Univ Georgia, Dept Geog, Athens, GA 30602 USA.
[Webster, James W.] US EPA, Atlanta, GA 30303 USA.
RP Moyes, H (reprint author), Univ Arizona, Dept Anthropol, Tucson, AZ 85745 USA.
EM hmoyes@email.arizona.edu; jaimeawe@yahoo.com; gabrook@uga.edu
NR 144
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U1 8
U2 26
PU SOC AMER ARCHAEOLOGY
PI WASHINGTON
PA 900 SECOND ST., NE STE 12, WASHINGTON, DC 20002-3557 USA
SN 1045-6635
J9 LAT AM ANTIQ
JI Lat. Am. Antiq.
PD MAR
PY 2009
VL 20
IS 1
BP 175
EP 206
PG 32
WC Archaeology
SC Archaeology
GA 429LM
UT WOS:000264921900010
ER
PT J
AU Ekman, DR
Teng, QN
Villeneuve, DL
Kahl, MD
Jensen, KM
Durhan, EJ
Ankley, GT
Collette, TW
AF Ekman, Drew R.
Teng, Quincy
Villeneuve, Daniel L.
Kahl, Michael D.
Jensen, Kathleen M.
Durhan, Elizabeth J.
Ankley, Gerald T.
Collette, Timothy W.
TI Profiling lipid metabolites yields unique information on sex- and
time-dependent responses of fathead minnows (Pimephales promelas)
exposed to 17 alpha-ethynylestradiol
SO METABOLOMICS
LA English
DT Article
DE Fish; Metabolomics; NMR; Estrogens; Lipids
ID FATTY-ACID COMPOSITION; HETEROPNEUSTES-FOSSILIS BLOCH; LOW-DENSITY
LIPOPROTEIN; TROUT SALMO-GAIRDNERI; ZOARCES-VIVIPARUS L; RAINBOW-TROUT;
ETHINYL ESTRADIOL; RAT-LIVER; CHOLESTEROL BIOSYNTHESIS;
CARBOHYDRATE-METABOLISM
AB Alterations in hepatic lipid profiles of fathead minnows (FHM) exposed to the synthetic estrogen 17 alpha-ethynylestradiol (EE2) were determined using (1)H-NMR spectroscopy-based metabolite profiling. The exposures were conducted using either 10 ng/l or 100 ng/l EE2 via a continuous flow water delivery system. Livers were collected at 1, 4, and 8 days of the exposure and 8 days after the chemical was removed from the water (i.e. an 8 day depuration). The exposure resulted in a number of sex-specific changes in lipid profiles that were also highly time dependent. Those metabolites most affected by exposure included phosphatidylcholine, diglycerides, triglycerides and cholesterol. In addition, changes in the length and degree of unsaturation of hepatic fatty acids were observed. Lipid profiles in plasma for fish collected on the 4th day of exposure were also analyzed in order to provide further insights into changes observed in hepatic metabolite changes. Using validated partial least-squares discriminant analysis (PLS-DA), the response trajectories of the male liver lipid profiles at both exposure concentrations were compared. This analysis indicated that the males exposed to the low concentration of EE2 (10 ng/l) were largely able to recover from the exposure once the chemical was removed from the water. Conversely, the males exposed to the high concentration (100 ng/l) did not appear to recover from the exposure despite the 8 day depuration.
C1 [Ekman, Drew R.; Teng, Quincy; Collette, Timothy W.] US EPA, Ecosyst Res Div, Athens, GA 30605 USA.
[Villeneuve, Daniel L.; Kahl, Michael D.; Jensen, Kathleen M.; Durhan, Elizabeth J.; Ankley, Gerald T.] US EPA, Mid Continent Ecol Div, Duluth, MN 55804 USA.
RP Ekman, DR (reprint author), US EPA, Ecosyst Res Div, 960 Coll Stn, Athens, GA 30605 USA.
EM ekman.drew@epa.gov
FU U. S. EPA National Center for Computational Toxicology; U. S. EPA Office
of Science Council Policy
FX This work has been subjected to review by the National Exposure Research
Laboratory and the National Health and Environmental Effects Research
Laboratory and approved for publication. Approval does not signify that
the contents reflect the views of the Agency, nor does mention of trade
names or commercial products constitute endorsement or recommendation
for use. This work was funded in part by the U. S. EPA National Center
for Computational Toxicology and the U. S. EPA Office of Science Council
Policy.
NR 62
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Z9 32
U1 1
U2 23
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1573-3882
J9 METABOLOMICS
JI Metabolomics
PD MAR
PY 2009
VL 5
IS 1
BP 22
EP 32
DI 10.1007/s11306-008-0138-y
PG 11
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 413MW
UT WOS:000263798200003
ER
PT J
AU Ma, WJ
Panduri, V
Sterling, JF
Van Houten, B
Gordenin, DA
Resnick, MA
AF Ma, Wenjian
Panduri, Vijayalakshmi
Sterling, Joan F.
Van Houten, Bennett
Gordenin, Dmitry A.
Resnick, Michael A.
TI The Transition of Closely Opposed Lesions to Double-Strand Breaks during
Long-Patch Base Excision Repair Is Prevented by the Coordinated Action
of DNA Polymerase delta and Rad27/Fen1
SO MOLECULAR AND CELLULAR BIOLOGY
LA English
DT Article
ID CELL NUCLEAR ANTIGEN; SACCHAROMYCES-CEREVISIAE; LIGASE I; BIOLOGICAL
CONSEQUENCES; OKAZAKI FRAGMENTS; REPLICATION FORK; ABASIC SITES; DAMAGE;
POL32; RADIATION
AB DNA double-strand breaks can result from closely opposed breaks induced directly in complementary strands. Alternatively, double-strand breaks could be generated during repair of clustered damage, where the repair of closely opposed lesions has to be well coordinated. Using single and multiple mutants of Saccharomyces cerevisiae ( budding yeast) that impede the interaction of DNA polymerase delta and the 5'-flap endonuclease Rad27/Fen1 with the PCNA sliding clamp, we show that the lack of coordination between these components during long-patch base excision repair of alkylation damage can result in many double-strand breaks within the chromosomes of nondividing haploid cells. This contrasts with the efficient repair of nonclustered methyl methanesulfonate-induced lesions, as measured by quantitative PCR and S1 nuclease cleavage of single-strand break sites. We conclude that closely opposed single-strand lesions are a unique threat to the genome and that repair of closely opposed strand damage requires greater spatial and temporal coordination between the participating proteins than does widely spaced damage in order to prevent the development of double-strand breaks.
C1 [Gordenin, Dmitry A.] Natl Inst Environm Hlth Sci, Chromosome Stabil Sect, Mol Genet Lab, NIH, Res Triangle Pk, NC 27709 USA.
[Van Houten, Bennett] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Inst Canc, Pittsburgh, PA 15213 USA.
RP Gordenin, DA (reprint author), Natl Inst Environm Hlth Sci, Chromosome Stabil Sect, Mol Genet Lab, NIH, Res Triangle Pk, NC 27709 USA.
EM gordenin@niehs.nih.gov; resnick@niehs.nih.gov
RI Ma, Wenjian/C-1071-2012
FU Intramural Research Program of the NIEHS [1 Z01 ES065073, 2 Z01 ES61062]
FX This work was supported by the Intramural Research Program of the NIEHS
(NIH, DHHS) under projects 1 Z01 ES065073 (M.A.R.) and 2 Z01 ES61062
(B.V.H.).
NR 61
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Z9 22
U1 3
U2 4
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0270-7306
J9 MOL CELL BIOL
JI Mol. Cell. Biol.
PD MAR 1
PY 2009
VL 29
IS 5
BP 1212
EP 1221
DI 10.1128/MCB.01499-08
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 406KI
UT WOS:000263293500011
PM 19075004
ER
PT J
AU Ross, JA
Moore, T
Leavitt, SA
AF Ross, Jeffrey A.
Moore, Tanya
Leavitt, Sharon A.
TI In vivo mutagenicity of conazole fungicides correlates with
tumorigenicity
SO MUTAGENESIS
LA English
DT Article
ID CONSTITUTIVE ANDROSTANE RECEPTOR; BLUE(R) TRANSGENIC MICE; B6C3F1
MOUSE-LIVER; CELL-PROLIFERATION; MUTANT FREQUENCY; NUCLEAR RECEPTOR;
MUTATION ASSAYS; LACI; PROPICONAZOLE; MYCLOBUTANIL
AB Triadimefon, propiconazole and myclobutanil are conazoles, an important class of agricultural and therapeutic fungicides. Triadimefon and propiconazole are mouse liver tumorigens, while myclobutanil is not. All three conazoles are generally inactive in short-term genotoxicity tests. We studied the in vivo mutagenicity of these three conazoles using the Big Blue (R) mouse assay system. Groups of mice were fed either control diet or diet containing 1800 p.p.m. triadimefon, 2500 p.p.m. propiconazole or 2000 p.p.m. myclobutanil. After 4 days of feeding, mice were immediately euthanized, livers were removed, DNA isolated and lacI genes recovered into infectious bacteriophage lambda particles by in vitro packaging. Bacteriophage with mutations in the lacI gene was detected by infecting into Escherichia coli, and mutant frequencies were determined using a colorimetric plaque assay. Propiconazole induced a 1.97-fold increase in mutant frequency compared to concurrent controls (P = 0.018) and triadimefon induced a 1.94-fold increase compared to concurrent controls (P = 0.009). Myclobutanil did not induce any change in mutant frequency (P = 0.548). These results provide the first evidence that the hepatotumorigenic conazoles are capable of inducing mutations in liver in vivo while the non-tumorigen myclobutanil is not, suggesting that mutagenicity may represent a key event in conazoles tumorigenic mode of action.
C1 [Ross, Jeffrey A.; Moore, Tanya; Leavitt, Sharon A.] US EPA, Div Environm Carcinogenesis, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
RP Ross, JA (reprint author), US EPA, Div Environm Carcinogenesis, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
EM ross.jeffrey@epamail.epa.gov
RI Moreira, Eder/B-2309-2010; Ross, Jeffrey/E-4782-2010
OI Ross, Jeffrey/0000-0002-7002-4548
NR 33
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U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0267-8357
J9 MUTAGENESIS
JI Mutagenesis
PD MAR
PY 2009
VL 24
IS 2
BP 149
EP 152
DI 10.1093/mutage/gen062
PG 4
WC Genetics & Heredity; Toxicology
SC Genetics & Heredity; Toxicology
GA 413YO
UT WOS:000263831300005
PM 19028983
ER
PT J
AU Guyton, KZ
Kyle, AD
Aubrecht, J
Cogliano, VJ
Eastmond, DA
Jackson, M
Keshava, N
Sandy, MS
Sonawane, B
Zhang, LP
Waters, MD
Smith, MT
AF Guyton, Kathryn Z.
Kyle, Amy D.
Aubrecht, Jiri
Cogliano, Vincent J.
Eastmond, David A.
Jackson, Marc
Keshava, Nagalakshmi
Sandy, Martha S.
Sonawane, Babasaheb
Zhang, Luoping
Waters, Michael D.
Smith, Martyn T.
TI Improving prediction of chemical carcinogenicity by considering multiple
mechanisms and applying toxicogenomic approaches
SO MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
LA English
DT Review
DE Carcinogenicity testing; Risk assessment; Genotoxicity battery
ID DOSE-RESPONSE RELATIONSHIPS; DISCRIMINATE RODENT CARCINOGENS; VITRO
GENOTOXICITY TESTS; GENE-EXPRESSION PROFILES; EXPOSED HUMAN-SUBJECTS;
RISK-ASSESSMENT; CHROMOSOMAL-ABERRATIONS; HUMAN CANCER;
SACCHAROMYCES-CEREVISIAE; RELATIVE PREDICTIVITY
AB While scientific knowledge of the potential health significance of chemical exposures has grown, experimental methods for predicting the carcinogenicity of environmental agents have not been substantially updated in the last two decades. Current methodologies focus first on identifying genotoxicants under the premise that agents capable of directly damaging DNA are most likely to be carcinogenic to humans. Emphasis on the distinction between genotoxic and non-genotoxic carcinogens is also motivated by assumed implications for the dose-response curve; it is purported that genotoxicants would lack a threshold in the low dose region, in contrast to non-genotoxic agents. However, for the vast majority of carcinogens, little if any empirical data exist to clarify the nature of the cancer dose-response relationship at low doses in the exposed human population. Recent advances in scientific understanding of cancer biology-and increased appreciation of the multiple impacts of carcinogens on this disease process-support the view that environmental chemicals can act through multiple toxicity pathways, modes and/or mechanisms of action to induce cancer and other adverse health outcomes. Moreover, the relationship between dose and a particular outcome in an individual could take multiple forms depending on genetic background, target tissue, internal dose and other factors besides mechanisms or modes of action: inter-individual variability and susceptibility in response are, in turn, key determinants of the population dose-response curve. New bioanalytical approaches (e.g., transcriptomics, proteomics, and metabolomics) applied in human, animal and in vitro studies could better characterize a wider array of hazard traits and improve the ability to predict the potential carcinogenicity of chemicals. Published by Elsevier B.V.
C1 [Guyton, Kathryn Z.; Keshava, Nagalakshmi; Sonawane, Babasaheb] US EPA, Natl Ctr Environm Assessment, Off Res & Dev, Washington, DC 20460 USA.
[Kyle, Amy D.; Zhang, Luoping; Smith, Martyn T.] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
[Aubrecht, Jiri] Pfizer Global Res & Dev, Drug Safety Res & Dev, Groton, CT 06340 USA.
[Cogliano, Vincent J.] Int Agcy Res Canc, F-69372 Lyon, France.
[Eastmond, David A.] Univ Calif Riverside, Environm Toxicol Grad Program, Riverside, CA 92521 USA.
[Eastmond, David A.] Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA.
[Jackson, Marc; Waters, Michael D.] Integrated Lab Syst Inc, Res Triangle Pk, NC 27709 USA.
[Sandy, Martha S.] Off Environm Hlth Hazard Assessment, Calif Environm Protect Agcy, Oakland, CA 94612 USA.
RP Guyton, KZ (reprint author), US EPA, Natl Ctr Environm Assessment, Off Res & Dev, 1200 Penn Ave NW, Washington, DC 20460 USA.
EM guyton.kate@epa.gov
FU US EPA [EP07HO01783]; Integrated Laboratory Systems (ILS), Inc.; Pfizer,
Inc; NIEHS Superfund Basic Research Program [P42ES004705]
FX This manuscript was motivated by a workshop chaired by MTS and MDW at
the 2007 Environmental Mutagen Society Annual Meeting entitled
"Predicting Chemical Carcinogenicity: Moving beyond Batteries". The
workshop was sponsored by US EPA (contract #EP07HO01783), Integrated
Laboratory Systems (ILS), Inc. and Pfizer, Inc. ADK, LZ and MTS are
supported by NIEHS Superfund Basic Research Program Grant P42ES004705.
NR 89
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U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1383-5742
J9 MUTAT RES-REV MUTAT
JI Mutat. Res.-Rev. Mutat. Res.
PD MAR-JUN
PY 2009
VL 681
IS 2-3
BP 230
EP 240
DI 10.1016/j.mrrev.2008.10.001
PG 11
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 417RQ
UT WOS:000264095000010
PM 19010444
ER
PT J
AU Laughlin, SK
Baird, DD
Savitz, DA
Herring, AH
Hartmann, KE
AF Laughlin, Shannon K.
Baird, Donna D.
Savitz, David A.
Herring, Amy H.
Hartmann, Katherine E.
TI Prevalence of Uterine Leiomyomas in the First Trimester of Pregnancy An
Ultrasound-Screening Study
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
ID LONGITUDINAL DATA-ANALYSIS; FOLLOW-UP; COMPLICATIONS; MYOMAS; FIBROIDS;
OUTCOMES; DIAGNOSIS; DELIVERY; MODELS; WOMEN
AB OBJECTIVE: To estimate the proportion of pregnant women with one or more leiomyomas detected by research-quality ultrasound screening in the first trimester, to describe the size and location of leiomyomas identified, and to report variation in prevalence by race/ethnicity.
METHODS: Within an ongoing prospective cohort, we conducted 4,271 first-trimester or postmiscarriage ultrasound examinations. Sonographers measured each leiomyoma three separate times, recording the maximum diameter in three perpendicular planes each time. Sonographers and investigators classified type and location.
RESULTS: Among 458 women with one or more leiomyomas (prevalence 10.7%), we identified a total of 687 leiomyomas. The mean size of the largest leiomyoma was 2.3 cm (95% confidence interval [CI] 1.8-2.8). Mean gestational age at ultrasonography was 61 +/- 13 days from last menstrual period. Prevalence varied by race/ethnicity: 18% in African-American women (95% CI 13-25), 8% in white women (95% Cl 7-11), and 10% in Hispanic women (95% CI 5-19). The proportion of women with leiomyomas increased with age much more steeply for African-American women than for white women.
CONCLUSION: Leiomyomas are common in pregnancy and occur more often among African-American women. Given the limited research on effects of leiomyomas on reproductive outcomes, the degree to which race/ethnic disparities in prevalence of leiomyomas may contribute to disparities in events such as miscarriage and preterm birth warrants investigation.
C1 Univ N Carolina, Dept Epidemiol, Sch Publ Hlth, Chapel Hill, NC USA.
Natl Inst Environm Hlth Sci, NIH, Res Triangle Pk, NC USA.
Mt Sinai Sch Med, New York, NY USA.
Univ N Carolina, Sch Publ Hlth, Biostat & Carolina Populat Ctr, Chapel Hill, NC USA.
Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Inst Med & Publ Hlth, Nashville, TN 37232 USA.
RP Hartmann, KE (reprint author), Vanderbilt Univ, Inst Med & Publ Hlth, 2525 W End Ave,Suite 600,6th Floor, Nashville, TN 37203 USA.
EM katherine.hartmann@vanderbilt.edu
RI Baird, Donna/D-5214-2017
OI Baird, Donna/0000-0002-5544-2653
FU NICHD [RO1 HDO43883-04]
FX Conducted as part of the Right from theStartstudy. Supported by the
American Water Works Association Research Foundation under contract
#2579 (Savitz); the Environmental Protection Agency Cooperative
Agreement R-82845507 (Savitz); Pfizer Scholars Grants for Faculty
Development in Clinical Epidemiology (Hartmann), NICHD RO1 HDO43883-04:
"Consequences and Course of Uterine Fibroids in Pregnancy" (Hartmann and
Herring); and the National Institutes of Health (NIH) Women's Health
Fellowships in Intramural Women's Health Research (Laughlin). Also
supported in part by the Intramural Research Program of the NIH,
National Institute of Environmental Health Sciences.
NR 26
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U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD MAR
PY 2009
VL 113
IS 3
BP 630
EP 635
PG 6
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 412UP
UT WOS:000263750000009
PM 19300327
ER
PT J
AU Wilson, JA
Parsons, JL
Jorgensen, EE
AF Wilson, James A.
Parsons, Jennifer L.
Jorgensen, Eric E.
TI Protein Nutrition of Southern Plains Small Mammals: Immune Response to
Variation in Maternal and Offspring Dietary Nitrogen
SO PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
LA English
DT Article
ID RATS SIGMODON HISPIDUS; MICE PEROMYSCUS-LEUCOPUS; COTTON RATS;
TRADE-OFFS; ENERGETIC COST; ACUTE BENZENE; SEX-RATIO; COMMUNITY; CHOICE;
GROWTH
AB Maternal nutrition during pregnancy and postnatal offspring nutrition may influence offspring traits. We investigated the effects of maternal and postweaning offspring dietary nitrogen on immune function and hematology in two species of rodent: the hispid cotton rat (Sigmodon hispidus), a primarily herbivorous rodent, and the fulvous harvest mouse (Reithrodontomys fulvescens), an omnivore. These two species responded differently to the same levels of treatment, with cotton rats primarily influenced by maternal diet and harvest mice by postweaning offspring diet. Cotton rats born to mothers on high-nitrogen diets had lower values of mean corpuscle volume and hemoglobin and greater concentrations of serum immunoglobulins. Spleen size, cell-mediated immune response, and the number of splenocytes and thymic platelets were lower in cotton rats born to mothers on low-and high-nitrogen diets. High-nitrogen offspring diet increased kidney and liver mass in cotton rats. Harvest mice had increased kidney mass on high-nitrogen maternal diets; however, changes in offspring diet after weaning reduced hematological parameters in individuals fed low-nitrogen diets. Body length was also affected, with harvest mice born to mothers fed low-and high-nitrogen diets having shorter lengths. Splenocyte cellular activity was greater in offspring born to mothers on high-nitrogen diets in both species.
C1 [Wilson, James A.; Parsons, Jennifer L.] Oklahoma State Univ, Dept Zool, Stillwater, OK 74078 USA.
[Jorgensen, Eric E.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Ada, OK 74820 USA.
RP Wilson, JA (reprint author), Univ Nebraska, Dept Biol, 6001 Dodge St, Omaha, NE 68182 USA.
EM gulywhumpr@sbcglobal.net
FU U. S. Environmental Protection Agency; Office of Research and
Development; National Risk Management Research Laboratory
[DW14938554-01-0]
FX This project was funded by the U. S. Environmental Protection Agency
(EPA), Office of Research and Development, National Risk Management
Research Laboratory, under Interagency Agreement DW14938554-01-0 with
the U. S. Geological Survey (USGS) Biological Resources Division and was
administered by the Oklahoma Cooperative Fish and Wildlife Research Unit
(Oklahoma State University, Oklahoma Department of Wildlife
Conservation, USGS Biological Resources Division, and Wildlife
Management Institute cooperating). The views expressed in this
manuscript are those of the authors and do not necessarily reflect the
views and policies of EPA or USGS. We appreciate the field and
laboratory assistance of L. Newby, E. Webb, and C. Deerenberg. We thank
the administrative, logistical, and design contributions of D. M. Leslie
Jr. and E. C. Hellgren. The contributions of the late R. L. Lochmiller
were important to the genesis of this project.
NR 61
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U1 0
U2 8
PU UNIV CHICAGO PRESS
PI CHICAGO
PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA
SN 1522-2152
J9 PHYSIOL BIOCHEM ZOOL
JI Physiol. Biochem. Zool.
PD MAR-APR
PY 2009
VL 82
IS 2
BP 170
EP 180
DI 10.1086/590919
PG 11
WC Physiology; Zoology
SC Physiology; Zoology
GA 410DD
UT WOS:000263555700008
PM 19199557
ER
PT J
AU Boyes, WK
Bercegeay, M
Oshiro, WM
Krantz, QT
Kenyon, EM
Bushnell, PJ
Benignus, VA
AF Boyes, William K.
Bercegeay, Mark
Oshiro, Wendy M.
Krantz, Q. Todd
Kenyon, Elaina M.
Bushnell, Philip J.
Benignus, Vernon A.
TI Acute Perchloroethylene Exposure Alters Rat Visual-Evoked Potentials in
Relation to Brain Concentrations
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE neurotoxicity; PBPK model; volatile organic compound; organic solvent;
visual-evoked potential
ID COLOR-VISION LOSS; LATERAL GENICULATE-NUCLEUS; VOLATILE
ORGANIC-SOLVENTS; ACUTE TOLUENE EXPOSURE; LONG-TERM EXPOSURE;
CONTRAST-SENSITIVITY; PARTITION-COEFFICIENTS; INHALED TRICHLOROETHYLENE;
MICROELECTRONICS WORKERS; PHARMACOKINETIC MODELS
AB These experiments sought to establish a dose-effect relationship between the concentration of perchloroethylene (PCE) in brain tissue and concurrent changes in visual function. A physiologically based pharmacokinetic (PBPK) model was implemented to predict concentrations of PCE in the brains of adult Long-Evans rats following inhalation exposure. The model was evaluated for performance against tissue concentrations from exposed rats (n = 40) and data from the published scientific literature. Visual function was assessed using steady-state pattern-elicited visual-evoked potentials (VEPs) recorded from rats during exposure to air or PCE in two experiments (total n = 84) with concentrations of PCE ranging from 250 to 4000 ppm. VEP waveforms were submitted to a spectral analysis in which the major response component, F2, occurring at twice the visual stimulation rate, was reduced in amplitude by PCE exposure. The F2 amplitudes were transformed to an effect-magnitude scale ranging from 0 (no effect) to 1 (maximum possible effect), and a logistical function was fit to the transformed values as a function of estimated concurrent brain PCE concentrations. The resultant function described a dose-response relationship between brain PCE concentration and changes in visual function with an ED(10) value of approximately 0.684 mg/l and an ED(50) value of approximately 46.5 mg/l. The results confirmed that visual function was disrupted by acute exposure to PCE, and the PBPK model and logistic model together could be used to make quantitative estimates of the magnitude of deficit to be expected for any given inhalation exposure scenario.
C1 [Boyes, William K.; Bercegeay, Mark; Oshiro, Wendy M.; Bushnell, Philip J.] US EPA, Div Neurotoxicol, Res Triangle Pk, NC 27711 USA.
[Krantz, Q. Todd; Kenyon, Elaina M.] US EPA, Expt Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Benignus, Vernon A.] US EPA, Human Studies Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
RP Boyes, WK (reprint author), US EPA, Div Neurotoxicol, B105-05, Res Triangle Pk, NC 27711 USA.
EM boyes.william@epa.gov
FU U. S. Environmental Protection Agency; Office of Research and
Development; National Health and Environmental Effects Research
Laboratory
FX The intramural research program of the U. S. Environmental Protection
Agency, Office of Research and Development, National Health and
Environmental Effects Research Laboratory.
NR 62
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U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD MAR
PY 2009
VL 108
IS 1
BP 159
EP 172
DI 10.1093/toxsci/kfn265
PG 14
WC Toxicology
SC Toxicology
GA 410VO
UT WOS:000263606600016
PM 19098276
ER
PT J
AU Heidenfelder, BL
Reif, DM
Harkema, JR
Hubal, EAC
Hudgens, EE
Bramble, LA
Wagner, JG
Morishita, M
Keeler, GJ
Edwards, SW
Gallagher, JE
AF Heidenfelder, Brooke L.
Reif, David M.
Harkema, Jack R.
Hubal, Elaine A. Cohen
Hudgens, Edward E.
Bramble, Lori A.
Wagner, James G.
Morishita, Masako
Keeler, Gerald J.
Edwards, Stephen W.
Gallagher, Jane E.
TI Comparative Microarray Analysis and Pulmonary Changes in Brown Norway
Rats Exposed to Ovalbumin and Concentrated Air Particulates
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE ovalbumin; allergen; asthma; particulate matter; remodeling;
inflammation; microarray
ID DIESEL EXHAUST PARTICLES; ENVIRONMENTAL TOBACCO-SMOKE; GENE-EXPRESSION
PROFILES; IGE PRODUCTION; ALLERGIC INFLAMMATION; EXTRACELLULAR-MATRIX;
NASAL EPITHELIUM; LUNG DEVELOPMENT; CIGARETTE-SMOKE; ASTHMA
AB The interaction between air particulates and genetic susceptibility has been implicated in the pathogenesis of asthma. The overall objective of this study was to determine the effects of inhalation exposure to environmentally relevant concentrated air particulates (CAPs) on the lungs of ovalbumin (ova) sensitized and challenged Brown Norway rats. Changes in gene expression were compared with lung tissue histopathology, morphometry, and biochemical and cellular parameters in bronchoalveolar lavage fluid (BALF). Ova challenge was responsible for the preponderance of gene expression changes, related largely to inflammation. CAPs exposure alone resulted in no significant gene expression changes, but CAPs and ova-exposed rodents exhibited an enhanced effect relative to ova alone with differentially expressed genes primarily related to inflammation and airway remodeling. Gene expression data was consistent with the biochemical and cellular analyses of the BALF, the pulmonary pathology, and morphometric changes when comparing the CAPs-ova group to the air-saline or CAPs-saline group. However, the gene expression data were more sensitive than the BALF cell type and number for assessing the effects of CAPs and ova versus the ova challenge alone. In addition, the gene expression results provided some additional insight into the TGF-beta-mediated molecular processes underlying these changes. The broad-based histopathology and functional genomic analyses demonstrate that exposure to CAPs exacerbates rodents with allergic inflammation induced by an allergen and suggests that asthmatics may be at increased risk for air pollution effects.
C1 [Heidenfelder, Brooke L.; Hudgens, Edward E.; Gallagher, Jane E.] US EPA, Human Studies Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Chapel Hill, NC 27711 USA.
[Reif, David M.; Hubal, Elaine A. Cohen] US EPA, Natl Ctr Computat Toxicol, Off Res & Dev, Chapel Hill, NC 27711 USA.
[Harkema, Jack R.; Bramble, Lori A.; Wagner, James G.] Michigan State Univ, Dept Pathobiol & Diagnost Invest, E Lansing, MI 48824 USA.
[Morishita, Masako; Keeler, Gerald J.] Univ Michigan, Air Qual Lab, Ann Arbor, MI 48109 USA.
[Edwards, Stephen W.] US EPA, Off Associate Director Hlth, Natl Hlth & Environm Effects Res Lab, Immediate Off,Off Res & Dev, Chapel Hill, NC 27711 USA.
RP Gallagher, JE (reprint author), US EPA, Human Studies Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Mail Drop 58C, Chapel Hill, NC 27711 USA.
EM gallagher.jane@epa.gov
OI Reif, David/0000-0001-7815-6767
FU United States Environmental Protection Agency [EPD07069, ED-D-07-017]
FX The research described in this paper was funded wholly by the United
States Environmental Protection Agency (EPD07069 to jh and ED-D-07-017
for Expression Analysis).
NR 69
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U1 2
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD MAR
PY 2009
VL 108
IS 1
BP 207
EP 221
DI 10.1093/toxsci/kfp005
PG 15
WC Toxicology
SC Toxicology
GA 410VO
UT WOS:000263606600020
PM 19176365
ER
PT J
AU Ross, PK
Woods, CG
Bradford, BU
Kosyk, S
Gatti, DM
Cunningham, ML
Rusyn, I
AF Ross, Pamela K.
Woods, Courtney G.
Bradford, Blair U.
Kosyk, Sana
Gatti, Daniel M.
Cunningham, Michael L.
Rusyn, Ivan
TI Time-course comparison of xenobiotic activators of CAR and PPAR alpha in
mouse liver
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Kupffer cells; PPAR alpha; Toxicogenomics; Microarrays
ID CONSTITUTIVE ANDROSTANE RECEPTOR; GENE-EXPRESSION; ACTIVE/ANDROSTANE
RECEPTOR; METABOLIZING-ENZYMES; PHENYTOIN INDUCTION; TUMOR PROMOTION;
RISK-ASSESSMENT; X RECEPTOR; MICE; WY-14,643
AB Constitutive androstane receptor (CAR) and peroxisome proliferator activated receptor (PPAR)a are transcription factors known to be primary mediators of liver effects, including carcinogenesis, by phenobarbital-like compounds and peroxisome proliferators, respectively, in rodents. Many similarities exist in the phenotypes elicited by these two classes of agents in rodent liver, and we hypothesized that the initial transcriptional responses to the xenobiotic activators of CAR and PPAR alpha will exhibit distinct patterns, but at later time-points these biological pathways will converge. In order to capture the global transcriptional changes that result from activation of these nuclear receptors over a time-course in the mouse liver, microarray technology was used. First, differences in basal expression of liver genes between C57BI/6J wildtype and Car-null mice were examined and 14 significantly differentially expressed genes were identified. Next, mice were treated with phenobarbital (100 mg/kg by gavage for 24 h, or 0.085% w/w diet for 7 or 28 days), and liver gene expression changes with regards to both time and treatment were identified. While several pathways related to cellular proliferation and metabolism were affected by phenobarbital in wildtype mice, no significant changes in gene expression were found over time in the Car-nulls. Next, we determined commonalities and differences in the temporal response to phenobarbital and WY-14,643, a prototypical activator of PPAR alpha. Gene expression signatures from livers of wild-type mice C57BI6/J mice treated with PB or WY-14,643 were compared. Similar pathways were affected by both compounds; however, considerable time-related differences were present. This study establishes common gene expression fingerprints of exposure to activators of CAR and PPAR alpha in rodent liver and demonstrates that despite similar phenotypic changes, molecular pathways differ between classes of chemical carcinogens. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Ross, Pamela K.; Bradford, Blair U.; Kosyk, Sana; Gatti, Daniel M.; Rusyn, Ivan] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
[Woods, Courtney G.] Hamner Inst Hlth Sci, Res Triangle Pk, NC USA.
[Woods, Courtney G.] ExxonMobil Biomed Sci, Annandale, NJ USA.
[Cunningham, Michael L.] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA.
RP Rusyn, I (reprint author), Univ N Carolina, Dept Environm Sci & Engn, 0031 Michael Hooker Res Ctr,CB 7431, Chapel Hill, NC 27599 USA.
EM iir@unc.edu
RI Rusyn, Ivan/S-2426-2016
FU NIH [ES12686, ES10126, ES11391]; EPA [RD832720, RD833825]; National
Institute of Environmental Health Sciences
FX We thank Drs. Fred Wright, David Threadgill and Chang Fan, and Ms.
Alison Hege with the University of North Carolina-Chapel Hill for
valuable assistance with data analysis and interpretation. We wish to
thank Mr. Jeffrey Davis at ILS, Research Triangle Park, NC for preparing
the diet used in this study. Financial support for these studies was
provided, in part, by grants from NIH (ES12686, ES10126 and ES11391) and
EPA (RD832720 and RD833825), and by the Intramural Research program of
the National Institute of Environmental Health Sciences. The content of
the manuscript does not reflect the views and policies of the EPA.
NR 37
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U2 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD MAR 1
PY 2009
VL 235
IS 2
BP 199
EP 207
DI 10.1016/j.taap.2008.12.011
PG 9
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 416GX
UT WOS:000263994900008
PM 19136022
ER
PT J
AU Butler, BA
AF Butler, Barbara A.
TI Effect of pH, ionic strength, dissolved organic carbon, time, and
particle size on metals release from mine drainage impacted streambed
sediments
SO WATER RESEARCH
LA English
DT Article
DE Sorption; Desorption; Acid-mine drainage remediation
ID SOILS; MANGANESE; CADMIUM; ACIDS; TRANSPORT; SORPTION; TRENDS; MN
AB Acid-mine drainage (AMD) input to a stream typically results in the stream having a reduced pH, increased concentrations of metals and salts, and decreased biological productivity. Removal and/or treatment of these AMD sources is desired to return the impacted stream(s) to initial conditions, or at least to conditions suitable for restoration of the aquatic ecosystem. Some expected changes in the water chemistry of the stream following removal of AMD input include an increase in pH, a decrease in ionic strength, and an increase in dissolved organic carbon (DOC) concentrations from increased biological activity in the absence of toxic metals concentrations. These changes in water chemistry may cause the existing contaminated bed sediments to become a source of metals to the stream water. Streambed sediments, collected from North Fork Clear Creek (NFCC), Colorado, currently impacted by AMD, were assessed for the effects of pH, ionic strength, DOC concentration, time, and particle size on metals release using a factorial design. The design included two levels for each chemical parameter (ionic strength = 40 and 80% lower than ambient; pH = 6 and 8; and DOC = 1 and 3 mg/l higher than ambient), ten sampling times (from zero to 48 h), and two size fractions of sediments (63 mu m <= x < 2 mm and <63 mu m). Greater concentrations of metals were released from the smaller sized sediments compared with the larger, with the exception of Cu. A mild acid digestion (0.6 M HCl) evaluated the amount of each metal that could be removed easily from each of the sediment size fractions. Release of all metals over all time points, treatments, and from both sediment sizes was less than 1% of the extractable concentrations, with the exception of Mn, which ranged from 4 to 7% from the smaller sized sediment. Greater percentages of the 0.6 M HCl-extractable concentrations of Cu, Fe, and Zn were released from the larger sized sediment, while this was true for release of Cd and Mn from the smaller sized sediment. Thus, at least for Cd and Mn, the observed higher concentrations released from the smaller sized sediment with each treatment solution is not simply a function of these particles having higher concentrations available for release, but that these metals also are more readily released from the smaller sediment particles versus the larger. DOC concentration strongly influenced the release of Cu; ionic strength strongly influenced the release of Cd, Mn, and Zn; and interaction effects were observed with the release of Cu, Mn, and Zn from the larger size fraction and with the release of Zn from the smaller size fraction, Overall, results suggest that the expected changes in water chemistry following removal/treatment of the AMD sources would result in a release of metals from the existing sediments, with a greater effect on the release of Cu and Fe, than on the release of Cd, Mn, and Zn. Published by Elsevier Ltd.
C1 US EPA, Off Res & Dev, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, Cincinnati, OH 45268 USA.
RP Butler, BA (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Land Remediat & Pollut Control Div, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM butler.barbara@epa.gov
NR 30
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U1 4
U2 41
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0043-1354
J9 WATER RES
JI Water Res.
PD MAR
PY 2009
VL 43
IS 5
BP 1392
EP 1402
DI 10.1016/j.watres.2008.12.009
PG 11
WC Engineering, Environmental; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA 425DD
UT WOS:000264616300025
PM 19110291
ER
PT J
AU Christensen, JR
Crumpton, WG
van der Valk, AG
AF Christensen, Jay R.
Crumpton, William G.
van der Valk, Arnold G.
TI ESTIMATING THE BREAKDOWN AND ACCUMULATION OF EMERGENT MACROPHYTE LITTER:
A MASS-BALANCE APPROACH
SO WETLANDS
LA English
DT Article
DE cattail; common reed; Delta Marsh; detritus; litter bag; whitetop
ID PHRAGMITES-COMMUNIS TRIN; FRESH-WATER WETLANDS; TYPHA-ANGUSTIFOLIA L;
NUTRIENT DYNAMICS; PRAIRIE MARSHES; ORGANIC-MATTER; DELTA-MARSH;
LEAF-LITTER; DECOMPOSITION; AUSTRALIS
AB Litter accumulation within emergent macrophyte marshes may significantly influence abiotic conditions and biota but litter is rarely considered in emergent macrophyte Studies. Litter is defined here as the standing and fallen dead plant material that can be collected using harvest methods in the field. Litter accumulation can be predicted by combining annual production with litter breakdown rates. Breakdown rates are typically measured using litter bag studies but these rates may also be measured using a mass-balance approach. A five year study conducted in Delta Marsh, Manitoba measured annual standing crop and harvested accumulated litter of Phragmites australis (Cav.) Trin., Typha glauca Godr., and Scolochloa festucacea (Willd.) Link. These species differ in their level of refractory material and hence the amount of litter that is expected to accumulate. Using annual estimates of standing crop and litter mass, a mass-balance model was used to estimate the litter breakdown rate for each species at three water levels. Mass-balance derived rates for Phragmites and Typha were significantly different (F(1, 14) = 5.07, p = 0.03) and also differed across water depths (F(2, 14) = 4.35, p = 0.04). For both species, predicted annual accumulations of litter tracked observed litter Values. The mass-balance approach, however, was not suitable for Scolochloa because there is no litter carry over from year to year. When compared to observed litter accumulations, estimates of litter accumulation made using litter bag breakdown rates consistently overestimated annual litter accumulation. In short, breakdown rates can be estimated using a mass-balance approach and can then provide more accurate estimates of annual litter accumulations emergent species With recalcitrant litter.
C1 [Christensen, Jay R.; Crumpton, William G.; van der Valk, Arnold G.] Iowa State Univ, Dept Ecol Evolut & Organismal Biol, Ames, IA 50010 USA.
RP Christensen, JR (reprint author), US EPA, Natl Exposure Res Lab, Div Environm Sci, 944 E Harmon Ave, Las Vegas, NV 89119 USA.
EM christensen.jay@epamail.epa.gov
FU Graduate college; Environmental Science; Ecology and Evolutionary
Biology Interdisciplinary; Department of Ecology, Evolution. and
Organismal Biology; United States Environmental Protection Agency
FX We thank Lisette Ross, Dale Wrubleski, and Henry Murkin at Ducks
Unlimited Canada for securing data from the MERP Studies and for helpful
insights; numerous field workers at the MERP Study that collected the
data used in this study. We thank Greg Stenback for help with data
organization and statistical analysis. We thank Philip Dixon, Mailha
Nash, David Bradford, Charles Lane, two anonymous reviewers, and editors
for their discussion and suggestions on previous drafts. Jana and Gref
Stenback, Bradley Miller, and Amy Christensen provided Jay Christensen
with constant encouragement and advice. Support was provided by the
Graduate college, the Environmental Science Program, the Ecology and
Evolutionary Biology Interdisciplinary Program, and the Department of
Ecology, Evolution. and Organismal Biology at Iowa State University. The
United States Environmental Protection Agency through its office of
Research and Development partially funded and collaborated in the
research of Jay Christensen, and the work has been subjected to Agency
review and approved publication.
NR 57
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U1 4
U2 18
PU SOC WETLAND SCIENTISTS
PI LAWRENCE
PA 810 E TENTH ST, P O BOX 1897, LAWRENCE, KS 66044 USA
SN 0277-5212
J9 WETLANDS
JI Wetlands
PD MAR
PY 2009
VL 29
IS 1
BP 204
EP 214
PG 11
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 434SN
UT WOS:000265294500021
ER
PT J
AU Stander, EK
Ehrenfeld, JG
AF Stander, Emilie K.
Ehrenfeld, Joan G.
TI RAPID ASSESSMENT OF URBAN WETLANDS: FUNCTIONAL ASSESSMENT MODEL
DEVELOPMENT AND EVALUATION
SO WETLANDS
LA English
DT Article
DE nitrogen; nitrate; denitrification; nitrification; HGM; hydrology; New
Jersey
ID FORESTED WETLANDS; HYDROGEOMORPHIC APPROACH; AQUATIC ECOSYSTEMS;
RIPARIAN ZONES; NEW-JERSEY; DENITRIFICATION; MITIGATION; SOILS; USA;
URBANIZATION
AB The objective of this Study was to test the ability of existing hydrogeomorphic (HGM) functional assessment models and our own proposed models to predict rates of nitrate production and removal. functions critical to water quality protection, in forested riparian wetlands in northeastern New Jersey. In particular, the relationship between rapidly measured structural indicators and complex nitrogen (N) Cycling functions was evaluated as well as the ability of generalized biogeochemical models to predict rates of specific N cycling processes. Additional models were designed specifically to predict net nitrification and denitrification rates, using both rapid and non-rapid variables based on known controlling factors on these two processes. Existing models and our Own rapid models were not able to describe net nitrification and denitrification rates in urban riparian wetlands. Our additional models based on non-rapid variables, quantified through long-term hydrological monitoring and laboratory analyses of soil properties, successfully described net nitrification rates, but Surprisingly failed to adequately predict denitrification rates. The high variability in hydrological and soil properties and the complexity of site-specific relationships between disturbance, altered hydrology, and hydrologically driven N cycling processes in urban wetlands restricts our ability to predict denitrification rates using simple models. It is recommended that functional assessment models be designed to describe specific, process-based functions which are based on structural indicators that are well linked to process rates. These indicators Should be based on measurements from at least one year of hydrological monitoring and from simple laboratory measurements of soil properties. Detailed studies populations of wetlands may be necessary to validate specific forms of models.
C1 [Stander, Emilie K.; Ehrenfeld, Joan G.] Rutgers State Univ, Sch Biol & Environm Sci, Dept Ecol Evolut & Nat Resources, New Brunswick, NJ 08901 USA.
RP Stander, EK (reprint author), US EPA, Natl Risk Management Res Lab, Urban Watershed Management Branch, 2890 Woodbridge Ave, Edison, NJ 08837 USA.
EM stander.emilie@epa.gov
FU EPA STAR; USGS/NIWR; New Jersey Water Resources Research Institute
FX We thank Peter Groffman, Tamar Barkay, and Wei-Xing Zhu for providing
helpful comments and suggestions on earlier versions of this paper,
Robert Hamilton. IV, Dave Lewis, Manisha Patel, Dave Berry, Ryan Sklar,
Seth Davis, Ann Lang, Adira Rybandt, Tammy Gotsch, and Kim Spiegel for
assistance with field data collection and laboratory analyses, and
Monica Palta for assistance with data analyses. Funding was provided by
USGS/NIWR and the New Jersey Water Resources Research Institute. E.
Stander was supported on an EPA STAR Graduate Fellowship for a portion
of this Study. The research described here has been Subjected to the
U.S. Environmental Protection Agency's peer and administrative review
and has been approved for publication its an EPA document. Use of trade
names or commercial products is for identification purposes only and
does not Constitute endorsement or recommendation for use by the EPA.
NR 51
TC 7
Z9 8
U1 0
U2 19
PU SOC WETLAND SCIENTISTS
PI LAWRENCE
PA 810 E TENTH ST, P O BOX 1897, LAWRENCE, KS 66044 USA
SN 0277-5212
J9 WETLANDS
JI Wetlands
PD MAR
PY 2009
VL 29
IS 1
BP 261
EP 276
PG 16
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 434SN
UT WOS:000265294500026
ER
PT J
AU Wang, K
Zhang, Y
Jang, C
Phillips, S
Wang, BY
AF Wang, Kai
Zhang, Yang
Jang, Carey
Phillips, Sharon
Wang, Binyu
TI Modeling intercontinental air pollution transport over the trans-Pacific
region in 2001 using the Community Multiscale Air Quality modeling
system
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
ID COMPREHENSIVE PERFORMANCE EVALUATION; 1999 SOUTHERN OXIDANTS; TRACE-P
EXPERIMENT; ASIAN DUST EVENTS; UNITED-STATES; PART I; ATMOSPHERIC
TRANSPORT; PARTICULATE MATTER; TROPOSPHERIC OZONE; REACTIVE NITROGEN
AB The Community Multiscale Air Quality modeling system is used to study the intercontinental transport of air pollution across the Pacific region. Baseline simulations are conducted for January, April, July, and October 2001 at a 108 km horizontal grid resolution. A sensitivity simulation is conducted for April 2001 to study the impact of Asian anthropogenic emissions on the United States's air quality. Process analysis is conducted to study pollutant formation and transport and to quantify the relative contributions of atmospheric processes to ozone (O-3) and fine particulate matter (PM2.5). Model simulations are evaluated with available surface, aircraft, and satellite observations. Simulated meteorology basically captures the synoptic pattern, but precipitation amounts are significantly underpredicted. Most of the PM2.5 components are overestimated over the United States and most gases are underestimated over east Asia. Simulated NO2 and CO columns agree well with satellite observations. Aerosol optical depths and tropospheric O-3 residuals are underpredicted, especially in July. The simulated horizontal fluxes and process analyses show that the transport in the lower free troposphere followed by a large-scale subsidence over the United States provides a major Asian pollution export pathway for most pollutants, while the transport in the planetary boundary layer also plays an important role, especially for CO, O-3, PM2.5, and SO42-. The background concentrations of O-3 and SO42- in the western United States can increase by similar to 1 ppb (similar to 2.5%) and 0.4 mu g m(-3) (similar to 20%) in monthly average, up to 2.5 ppb and 1.0 mu g m(-3) in daily average, respectively, due to the Asian emissions in April.
C1 [Wang, Kai; Zhang, Yang; Wang, Binyu] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Jang, Carey; Phillips, Sharon] US EPA, Off Air Qual Planning & Stand, Res Triangle Pk, NC 27711 USA.
RP Wang, K (reprint author), N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Campus Box 8208, Raleigh, NC 27695 USA.
EM yang_zhang@ncsu.edu
RI Wang, Kai/D-4262-2013
OI Wang, Kai/0000-0002-2375-5989
FU U. S. EPA's ICAP; NASA [NNG04GJ90G]
FX This work was supported by the U. S. EPA's ICAP project and the NASA
award NNG04GJ90G. Thanks are due to Hilary E. Snell, AER Inc., U. S.,
for providing the MODIS, GOME, and MOPITT satellite data; Jack Fishman
and John K. Creilson, NASA Langley Research Center, U. S., for providing
the TOMS/SBUV satellite data; Ji-Ming Hao and Ke-Bin He, Tsinghua
University, China, for providing the observational data in Beijing,
China; Takigawa Masayuki, the Frontier Research Center for Global
Change, Japan, for providing the codes for the extraction of Japan data;
KrishVijayaraghavan, AER Inc., U. S., for providing Fortran codes for
column abundance calculations of different chemical species; Alice
Gilliland and Steve Howard, U. S. NOAA/EPA, for providing observational
data from national networks over U. S. and the Fortran code for
extracting data from observational databases and CMAQ; Shao-Cai Yu, the
NOAA/U.S. EPA, for providing Fortran codes for statistical calculations;
and Tanya L. Otte, the NOAA/U.S. EPA, for providing Fortran codes for 10
m wind speed calculation from other altitudes.
NR 75
TC 35
Z9 37
U1 0
U2 13
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
EI 2169-8996
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD FEB 27
PY 2009
VL 114
AR D04307
DI 10.1029/2008JD010807
PG 23
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 412OC
UT WOS:000263733100003
ER
PT J
AU Simon, H
Kimura, Y
McGaughey, G
Allen, DT
Brown, SS
Osthoff, HD
Roberts, JM
Byun, D
Lee, D
AF Simon, H.
Kimura, Y.
McGaughey, G.
Allen, D. T.
Brown, S. S.
Osthoff, H. D.
Roberts, J. M.
Byun, D.
Lee, D.
TI Modeling the impact of ClNO2 on ozone formation in the Houston area
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Article
ID VOLATILE ORGANIC-COMPOUNDS; SOUTHEAST TEXAS; CHLORINE EMISSIONS; CARBON
BOND; URBAN; CHEMISTRY; MECHANISM; KINETICS
AB During the summer of 2006, nitryl chloride (ClNO2) mixing ratios of over 1 ppb were measured in the Houston urban area. Nitryl chloride is potentially important to atmospheric chemistry in urban environments because its photolysis products include both NO2 and chlorine atoms. Chlorine atoms have previously been shown to significantly increase ozone formation in urban Houston. Photochemical modeling was performed using the Comprehensive Air quality Model with extensions (CAMx) to estimate the effects of observed nitryl chloride concentrations on local chemistry in southeast Texas. CAMx was modified to include a formation mechanism for nitryl chloride as well as its photolysis reaction. Comparisons between model predictions and ambient measurements showed that the model-predicted ClNO2 concentrations were within the range of observed data. Model simulations predict that ClNO2 increases total reactive chlorine mass by 20-40% in the atmosphere of southeast Texas. Despite the high reactivity of chlorine, nitryl chloride caused only modest increases in ozone concentrations ( up to 1.0-1.5 ppb when baseline 1-h average ozone concentrations were between 60 and 85 ppb). The chemistry and physical processes which affect ozone formation were further investigated using box model simulations and a Lagrangian process analysis tool (LPA) within the gridded photochemical modeling simulations. These analyses showed that vertical dispersion and local atmospheric composition moderated the effect of nitryl chloride on ozone mixing ratios.
C1 [Simon, H.] US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Simon, H.; Kimura, Y.; McGaughey, G.; Allen, D. T.] Univ Texas Austin, Ctr Energy & Environm Resources, Austin, TX 78758 USA.
[Brown, S. S.; Osthoff, H. D.; Roberts, J. M.] NOAA, ESRL, Div Chem Sci, Boulder, CO 80305 USA.
[Byun, D.; Lee, D.] Univ Houston, Dept Earth & Atmospher Sci, Houston, TX 77204 USA.
RP Simon, H (reprint author), US EPA, Atmospher Modeling & Anal Div, Natl Exposure Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM simon.heather@epa.gov
RI Roberts, James/A-1082-2009; simon, heather/E-4392-2011; Brown,
Steven/I-1762-2013; Manager, CSD Publications/B-2789-2015
OI Roberts, James/0000-0002-8485-8172; simon, heather/0000-0001-7254-3360;
FU Texas Air Research Center
FX The authors thank Eric Williams and Brian Lerner (NOAA/ESRL Chemical
Sciences Division) for the use of CO and NOx measurement data
taken on board the R/V Ronald H. Brown. The authors also thank Joost A.
de Gouw (NOAA/ESRL Chemical Sciences Division and CIRES), Jessica Gilman
( NOAA/ESRL Chemical Sciences Division and CIRES), and William C. Kuster
( NOAA/ESRL Chemical Sciences Division) for the use of their GC mass
spectrometry data taken on board the R/V Ronald H. Brown and for their
comments on preliminary versions of this manuscript. The United States
Environmental Protection Agency through its Office of Research and
Development collaborated in the research described here. It has been
subjected to agency review and approved for publication. Support for
this work was provided by the Texas Air Research Center.
NR 25
TC 30
Z9 30
U1 10
U2 27
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD FEB 18
PY 2009
VL 114
AR D00F03
DI 10.1029/2008JD010732
PG 17
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 410XS
UT WOS:000263612200006
ER
PT J
AU Fiore, AM
Dentener, FJ
Wild, O
Cuvelier, C
Schultz, MG
Hess, P
Textor, C
Schulz, M
Doherty, RM
Horowitz, LW
MacKenzie, IA
Sanderson, MG
Shindell, DT
Stevenson, DS
Szopa, S
Van Dingenen, R
Zeng, G
Atherton, C
Bergmann, D
Bey, I
Carmichael, G
Collins, WJ
Duncan, BN
Faluvegi, G
Folberth, G
Gauss, M
Gong, S
Hauglustaine, D
Holloway, T
Isaksen, ISA
Jacob, DJ
Jonson, JE
Kaminski, JW
Keating, TJ
Lupu, A
Marmer, E
Montanaro, V
Park, RJ
Pitari, G
Pringle, KJ
Pyle, JA
Schroeder, S
Vivanco, MG
Wind, P
Wojcik, G
Wu, S
Zuber, A
AF Fiore, A. M.
Dentener, F. J.
Wild, O.
Cuvelier, C.
Schultz, M. G.
Hess, P.
Textor, C.
Schulz, M.
Doherty, R. M.
Horowitz, L. W.
MacKenzie, I. A.
Sanderson, M. G.
Shindell, D. T.
Stevenson, D. S.
Szopa, S.
Van Dingenen, R.
Zeng, G.
Atherton, C.
Bergmann, D.
Bey, I.
Carmichael, G.
Collins, W. J.
Duncan, B. N.
Faluvegi, G.
Folberth, G.
Gauss, M.
Gong, S.
Hauglustaine, D.
Holloway, T.
Isaksen, I. S. A.
Jacob, D. J.
Jonson, J. E.
Kaminski, J. W.
Keating, T. J.
Lupu, A.
Marmer, E.
Montanaro, V.
Park, R. J.
Pitari, G.
Pringle, K. J.
Pyle, J. A.
Schroeder, S.
Vivanco, M. G.
Wind, P.
Wojcik, G.
Wu, S.
Zuber, A.
TI Multimodel estimates of intercontinental source-receptor relationships
for ozone pollution
SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
LA English
DT Review
ID EASTERN UNITED-STATES; REGIONAL AIR-QUALITY; MICS-ASIA-II; TROPOSPHERIC
OZONE; SURFACE OZONE; CARBON-MONOXIDE; NORTH-AMERICA; MACE-HEAD;
BACKGROUND OZONE; TRANSATLANTIC TRANSPORT
AB Understanding the surface O-3 response over a "receptor" region to emission changes over a foreign "source" region is key to evaluating the potential gains from an international approach to abate ozone (O-3) pollution. We apply an ensemble of 21 global and hemispheric chemical transport models to estimate the spatial average surface O-3 response over east Asia (EA), Europe (EU), North America (NA), and south Asia (SA) to 20% decreases in anthropogenic emissions of the O-3 precursors, NOx, NMVOC, and CO (individually and combined), from each of these regions. We find that the ensemble mean surface O-3 concentrations in the base case (year 2001) simulation matches available observations throughout the year over EU but overestimates them by > 10 ppb during summer and early fall over the eastern United States and Japan. The sum of the O-3 responses to NOx, CO, and NMVOC decreases separately is approximately equal to that from a simultaneous reduction of all precursors. We define a continental-scale "import sensitivity" as the ratio of the O-3 response to the 20% reductions in foreign versus "domestic" (i.e., over the source region itself) emissions. For example, the combined reduction of emissions from the three foreign regions produces an ensemble spatial mean decrease of 0.6 ppb over EU (0.4 ppb from NA), less than the 0.8 ppb from the reduction of EU emissions, leading to an import sensitivity ratio of 0.7. The ensemble mean surface O-3 response to foreign emissions is largest in spring and late fall (0.7-0.9 ppb decrease in all regions from the combined precursor reductions in the three foreign regions), with import sensitivities ranging from 0.5 to 1.1 (responses to domestic emission reductions are 0.8-1.6 ppb). High O-3 values are much more sensitive to domestic emissions than to foreign emissions, as indicated by lower import sensitivities of 0.2 to 0.3 during July in EA, EU, and NA when O-3 levels are typically highest and by the weaker relative response of annual incidences of daily maximum 8-h average O-3 above 60 ppb to emission reductions in a foreign region(< 10-20% of that to domestic) as compared to the annual mean response (up to 50% of that to domestic). Applying the ensemble annual mean results to changes in anthropogenic emissions from 1996 to 2002, we estimate a Northern Hemispheric increase in background surface O-3 of about 0.1 ppb a(-1), at the low end of the 0.1-0.5 ppb a(-1) derived from observations. From an additional simulation in which global atmospheric methane was reduced, we infer that 20% reductions in anthropogenic methane emissions from a foreign source region would yield an O-3 response in a receptor region that roughly equals that produced by combined 20% reductions of anthropogenic NOx, NMVOC, and CO emissions from the foreign source
C1 [Fiore, A. M.; Horowitz, L. W.] NOAA, Geophys Fluid Dynam Lab, Princeton, NJ 08542 USA.
[Dentener, F. J.; Cuvelier, C.; Van Dingenen, R.; Marmer, E.] Commiss European Communities, Inst Environm & Sustainabil, DG Joint Res Ctr, I-21020 Ispra, Italy.
[Wild, O.] Univ Lancaster, Dept Environm Sci, Lancester Environm Ctr, Lancaster LA1 4YQ, England.
[Schultz, M. G.; Schroeder, S.] Forschungszentrum Julich, ICG 2, D-52425 Julich, Germany.
[Hess, P.] Cornell Univ, Ithaca, NY 14853 USA.
[Textor, C.] Univ Paris 06, GMES France Atmosphere, Serv Aeron, INSU,CNRS, F-75252 Paris, France.
[Textor, C.; Schulz, M.; Szopa, S.; Hauglustaine, D.] CNRS, UVSQ, IPSL, CEA,Lab Sci Climat & Environm, F-91191 Gif Sur Yvette, France.
[Doherty, R. M.; MacKenzie, I. A.; Stevenson, D. S.] Univ Edinburgh, Sch GeoSci, Edinburgh EH9 3JN, Midlothian, Scotland.
[Sanderson, M. G.; Collins, W. J.; Pringle, K. J.] Hadley Ctr, Met Off, Exeter EX1 3PB, Devon, England.
[Shindell, D. T.; Faluvegi, G.] Columbia Univ, NASA, Goddard Inst Space Studies, New York, NY 10025 USA.
[Zeng, G.; Pyle, J. A.] Univ Cambridge, Dept Chem, Natl Ctr Atmospher Sci, Cambridge CB2 1EW, England.
[Atherton, C.; Bergmann, D.] Lawrence Livermore Natl Lab, Atmospher Earth & Energy Div, Livermore, CA 94551 USA.
[Bey, I.; Folberth, G.] Ecole Polytech Fed Lausanne, Lab Modelisat Chim Atmospher, CH-1015 Lausanne, Switzerland.
[Carmichael, G.] Univ Iowa, Coll Engn, Ctr Global & Reg Environm Res, Iowa City, IA 52242 USA.
[Duncan, B. N.] NASA, Goddard Space Flight Ctr, UMBC Goddard Earth Sci & Technol Ctr, Greenbelt, MD 20771 USA.
[Gauss, M.; Isaksen, I. S. A.] Univ Oslo, Dept Geosci, N-0315 Oslo, Norway.
[Gong, S.] Environm Canada, Air Qual Res Div, Sci & Technol Branch, Toronto, ON, Canada.
[Hauglustaine, D.] European Sci Fdn, Life Earth & Environm Sci, F-67080 Strasbourg, France.
[Holloway, T.] Univ Wisconsin, Ctr Sustainabil & Global Environm, Nelson Inst Environm Studies, Madison, WI 53726 USA.
[Park, R. J.] Seoul Natl Univ, Sch Earth & Environm Sci, Seoul 151742, South Korea.
[Jonson, J. E.; Wind, P.] Norwegian Meteorol Inst, Oslo, Norway.
[Kaminski, J. W.; Lupu, A.] York Univ, Ctr Res Earth & Space Sci, Toronto, ON M3J 1P3, Canada.
[Keating, T. J.] US EPA, Off Air & Radiat, Washington, DC 20460 USA.
[Montanaro, V.; Pitari, G.] Univ Aquila, Dept Phys, I-67100 Laquila, Italy.
[Vivanco, M. G.] CIEMAT, Atmospher Pollut Unit, E-28040 Madrid, Spain.
[Wojcik, G.] Northrop Grumman Corp, Atmospher Effects Grp, Chantilly, VA 20151 USA.
[Zuber, A.] Commiss European Communities, Environm Directorate Gen, B-1049 Brussels, Belgium.
[Jacob, D. J.; Park, R. J.; Wu, S.] Harvard Univ, Atmospher Chem Modeling Grp, Cambridge, MA 02138 USA.
RP Fiore, AM (reprint author), NOAA, Geophys Fluid Dynam Lab, 201 Forrestal Rd, Princeton, NJ 08542 USA.
EM Arlene.Fiore@noaa.gov; frank.dentener@jrc.it; O.Wild@lancaster.ac.uk;
kees.cuvelier@jrc.it; m.schultz@fz-juelich.de; hess@ucar.edu;
christiane.textor@aero.jussieu.fr; michael.schulz@isce.ipsl.fr;
ruth.doherty@ed.ac.uk; Larry.Horowitz@noaa.gov;
iamack@staffmail.ed.ac.uk; Michael.sanderson@metoffice.gov.uk;
dshindell@giss.nasa.gov; dstevens@staffmail.ed.ac.uk;
sophie.szopa@Isce.ipsl.fr; rita.van-dingenen@jrc.it;
Cynthia.Atherton@moore.org; dbergmann@llnl.gov; isabelle.bey@epfl.ch;
gcarmich@engineering.uiowa.edu; bill.collins@metoffice.gov.uk;
Bryan.N.Duncan@nasa.gov; greg.faluvegi@gmail.com;
gerd.folberth@metoffice.gov.uk; Michael.gauss@geo.uio.no;
Sunling.Gong@ec.gc.ca; dhauglustaine@esf.org; taholloway@wisc.edu;
ivar.isaksen@geofysikk.uio.no; djacob@fas.harvard.edu;
jan.eiof.jonson@met.no; jacek@yorku.ca; Keating.Terry@epamail.epa.gov;
alexlupu@yorku.ca; elina.marmer@jrc.it;
veronica.montanaro@aquila.infn.it; rjpark@snu.ac.kr;
gianni.pitari@aquila.infn.it; pringle@mpch-mainz.mpg.de;
John.Pyle@atm.ch.cam.ac.uk; s.schroeder@fz-juelich.de;
m.garcia@ciemat.es; peter.wind@met.no; gary.wojcik@ngc.com;
slwu@mtu.edu; Andre.ZUBER@ec.europa.eu
RI Horowitz, Larry/D-8048-2014; Vivanco, Marta/L-9816-2014; Park,
Rokjin/I-5055-2012; Hess, Peter/M-3145-2015; Schulz,
Michael/A-6930-2011; Pitari, Giovanni/O-7458-2016; Pringle, Kirsty
/A-4697-2013; Pfister, Gabriele/A-9349-2008; Wild, Oliver/A-4909-2009;
Collins, William/A-5895-2010; Folberth, Gerd/F-7376-2010; Szopa,
Sophie/F-8984-2010; mackenzie, ian/E-9320-2013; Lupu,
Alexandru/D-3689-2009; Bergmann, Daniel/F-9801-2011; Stevenson,
David/C-8089-2012; Shindell, Drew/D-4636-2012; Duncan,
Bryan/A-5962-2011; Schultz, Martin/I-9512-2012
OI Horowitz, Larry/0000-0002-5886-3314; Vivanco, Marta/0000-0002-5828-1859;
Park, Rokjin/0000-0001-8922-0234; Hess, Peter/0000-0003-2439-3796;
Schulz, Michael/0000-0003-4493-4158; Pitari,
Giovanni/0000-0001-7051-9578; Folberth, Gerd/0000-0002-1075-440X; Wild,
Oliver/0000-0002-6227-7035; Collins, William/0000-0002-7419-0850; Szopa,
Sophie/0000-0002-8641-1737; Lupu, Alexandru/0000-0002-4520-5523;
Bergmann, Daniel/0000-0003-4357-6301; Stevenson,
David/0000-0002-4745-5673; Schultz, Martin/0000-0003-3455-774X
FU U.S. DOE Atmospheric Science Program (Office of Science, BER) at LLNL
[DE-AC52-07NA27344]; NERC [NE/D012538/1]; NASA; UK Defra [AQ902]; DECC
[GA01101]; MoD [CBC/2B/0417_Annex C5]; Canadian Foundation for Climate
and Atmospheric Sciences; Ontario Ministry of the Environment; Canadian
Foundation for Innovation; Ontario Innovation Trust; Spanish Ministry of
the Environment; Korea Meteorological Administration Research and
Development Program [CATER 2007-3205]
FX We are grateful to D. Jaffe and D. Reidmiller (University of
Washington), and to A. Gnanadesikan and R. Stouffer (GFDL) and three
anonymous reviewers for insightful comments on previous versions of the
manuscript. C. A. and D. B. were supported primarily by the U.S. DOE
Atmospheric Science Program (Office of Science, BER) at LLNL under
contract DE-AC52-07NA27344. R. M. D., I. A. M., and D. S. S. acknowledge
funding from NERC (NE/D012538/1); B.N.D. from NASA MAP; M. G. S.,
K.J.P., and W.J.C. from the UK Defra under contract AQ902 and the Joint
DECC and MoD Programme, (DECC) GA01101 (MoD) CBC/2B/0417_Annex C5; A. L.
and J. W. K. from the Canadian Foundation for Climate and Atmospheric
Sciences, the Ontario Ministry of the Environment, the Canadian
Foundation for Innovation and the Ontario Innovation Trust; and M. G. V.
from the Spanish Ministry of the Environment. R. J. P. was partly
supported by the Korea Meteorological Administration Research and
Development Program under grant CATER 2007-3205.
NR 103
TC 183
Z9 187
U1 50
U2 173
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-897X
EI 2169-8996
J9 J GEOPHYS RES-ATMOS
JI J. Geophys. Res.-Atmos.
PD FEB 17
PY 2009
VL 114
AR D04301
DI 10.1029/2008JD010816
PG 21
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 410XQ
UT WOS:000263612000001
ER
PT J
AU Venier, M
Ferrario, J
Hites, RA
AF Venier, Marta
Ferrario, Joseph
Hites, Ronald A.
TI Polychlorinated Dibenzo-p-dioxins and Dibenzofurans in the Atmosphere
Around the Great Lakes
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID AMBIENT AIR; PCDD/FS; PCDDS/PCDFS; DEPOSITION; FURANS; AREAS; PCBS
AB The atmospheric concentrations of PCDDs and PCDFs were measured in four sites near the shores of the North American Great Lakes. The sites included an urban site (Chicago, Illinois) and three rural/remote sites (Eagle Harbor, Michigan; Sleeping Bear Dunes, Michigan; and Sturgeon Point, New York). Sampling occurred every 24 days between November 2004 and December 2007. The concentration of PCDD/Fs averaged 2.3 +/- 0.2 fg WHO TEQ/m(3) at Eagle Harbor, 35 +/- 3 fg WHO TEQ/m(3) at Chicago, 7.4 +/- 1.4 fg WHO TEO/m3 at Sleeping Bear Dunes, and 13 +/- 2 fg WHO TEQ/m(3) at Sturgeon Point The total concentration of the 17 toxic PCDD/F congeners showed a significant seasonal trend at all sites, except Chicago. The date of maximum concentration averaged Dec 6 +/- 35 days, which is consistent with residential heating being an important source of PCDD/Fs to the atmosphere. A significant positive relationship between the logarithm of the total concentration of the 17 toxic PCDD/F congeners and the logarithm of the number of people within a 25 km radius around the sampling site was found. We suggest that urban and industrial areas, which are heavily populated, act as sources of PCDDs and PCDFs to the atmosphere.
C1 [Venier, Marta; Hites, Ronald A.] Indiana Univ, Sch Publ & Environm Affairs, Bloomington, IN 47405 USA.
[Ferrario, Joseph] US EPA, Environm Chem Lab, OPP BEAD, Stennis Space Ctr, MS 39520 USA.
RP Hites, RA (reprint author), Indiana Univ, Sch Publ & Environm Affairs, Bloomington, IN 47405 USA.
EM hitesr@indiana.edu
FU U.S. Environmental Protection Agency
FX We thank the Great Lakes Commission for funding (Project Officer Jon
Dettling); Ilora Basu and Team IADN for the operation of the network;
David Cleverly at the U.S. Environmental Protection Agency for supplying
the NDAMN data; Chris Byrne, Tripp Boone, and Craig Vigo (all from the
EPA/ OPP/BEAD Environmental Chemistry Laboratory) for QA/ QC,
coordination of sample preparation, and for HRMS analyses, respectively.
Although the research described in this paper has been partially funded
by the U.S. Environmental Protection Agency, it has not been subjected
to the Agency's peer and administrative review and, therefore, may not
necessarily reflect the views of the EPA; nor does the mention of trade
names or commercial products constitute endorsement or recommendation of
use.
NR 28
TC 23
Z9 23
U1 2
U2 11
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD FEB 15
PY 2009
VL 43
IS 4
BP 1036
EP 1041
DI 10.1021/es802644w
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 406MC
UT WOS:000263298600014
PM 19320154
ER
PT J
AU Zhang, HC
Weber, EJ
AF Zhang, Huichun
Weber, Eric J.
TI Elucidating the Role of Electron Shuttles in Reductive Transformations
in Anaerobic Sediments
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID DISSOLVED ORGANIC-MATTER; HOMOGENEOUS AQUEOUS-SOLUTION; HUMIC
SUBSTANCES; FLUORESCENCE SPECTROSCOPY; NITROAROMATIC COMPOUNDS;
CARBON-TETRACHLORIDE; MEDIATED REDUCTION; ABIOTIC REDUCTION;
OXIDATION-STATE; IRON PORPHYRIN
AB Model studies have demonstrated that electron shuttles (ES) such as dissolved organic matter (DOM) can participate in the reduction of organic contaminants; however, much uncertainty exists concerning the significance of this solution phase pathway for contaminant reduction in natural systems. To compare the identity and reactivity of ES in anaerobic sediments with those in model systems, two chemical probes (4-cyano-4'-aminoazobenzene (CNAAzB) either free or covalently bound to glass beads) were synthesized that allowed for differentiation between surface-associated and solution-phase electron-transfer processes. The feasibility of these chemical probes were demonstrated in abiotic model systems (Fe(II)/Fe(III) oxide) and biotic model systems (Fe(II)/Fe(III) oxide or river sediment amended with S. putrefaciens strain cells). Experiments in the abiotic systems revealed that the addition of model hydroquinones and chemically reduced DOM increased reduction rates of free CNAAzB, whereas no enhancement in reactivity was observed with the addition of model quinones or DOM. Bound CNAAzB was also reduced by model hydroquinones and reduced DOM-but not by model quinones and untreated DOM-in the abiotic model systems, indicating that Fe(II)/Fe(III) oxides do not function as a bulk reductant for the reduction of ES. Addition of model quinones or untreated DOM to the biotic models systems with sediment increased reduction rates of bound CNAAzB, which correlated well with the dissolved organic carbon content. In natural sediment slurries, reduction rates of bound CNAAzB correlated well with parameters for organic carbon (OC) content of both sediments and supernatants. Our results support a scenario in which reducible organic contaminants will compete with iron oxides for the electron flow generated by the microbially mediated oxidation of organic carbon and subsequent reduction of quinone functional groups associated with DOM.
C1 [Zhang, Huichun; Weber, Eric J.] US EPA, Natl Exposure Res Lab, Athens, GA 30605 USA.
RP Weber, EJ (reprint author), US EPA, Natl Exposure Res Lab, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM weber.eric@epa.gov
NR 40
TC 20
Z9 25
U1 10
U2 50
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD FEB 15
PY 2009
VL 43
IS 4
BP 1042
EP 1048
DI 10.1021/es8017072
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 406MC
UT WOS:000263298600015
PM 19320155
ER
PT J
AU Ge, ZF
Frick, WE
AF Ge, Zhongfu
Frick, Walter E.
TI Time-frequency Analysis of Beach Bacteria Variations and its Implication
for Recreational Water Quality Modeling
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ESCHERICHIA-COLI CONCENTRATIONS; SIGNIFICANCE TESTS; SPECTRUM
AB This paper exploited the potential of the wavelet analysis in resolving beach bacteria concentration and candidate explanatory variables across multiple time scales with temporal information preserved. The wavelet transform of E. coli concentration and its explanatory variables observed at Huntington Beach, Ohio in 2006 exhibited well-defined patterns of different time scales, phases, and durations, which cannot be clearly shown in conventional time-domain analyses. If linear regression modeling is to be used for the ease of implementation and interpretation, the wave let-transformed regression model reveals that low model residual can be realized through matching major patterns and their phase angles between E. coli concentration and its explanatory variables. The property of pattern matching for linear regression models can be adopted as a criterion for choosing useful predictors, while phase matching further explains why intuitively good variables such as wave height and onshore wind speed were excluded from the optimal models by model selection processes in Frick et al. (Environ. Sci. Technol. 2008, 42, 4818-4824). The phase angles defined by the wavelet analysis in the time-frequency domain can help identify the physical processes and interactions occurring between bacteria concentration and its explanatory variables. It was deduced, for this particular case, that wind events resulted in elevated E. coli concentration, wave height, and turbidity at the beach with a periodicity of 7-8 days. Wind events also brought about increased beach bacteria concentrations through large-scale current circulations in the lake with a period of 21 days. The time length for linear regression models with statistical robustness can also be deduced from the periods of the major patterns in bacteria concentration and explanatory variables, which explains and supplements the modeling efforts performed in (1).
C1 [Ge, Zhongfu] US EPA, Natl Res Council, Ecosyst Res Div, Athens, GA 30605 USA.
RP Ge, ZF (reprint author), US EPA, Natl Res Council, Ecosyst Res Div, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM gezhfu@yahoo.com; frick.walter@epa.gov
NR 18
TC 9
Z9 9
U1 1
U2 11
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD FEB 15
PY 2009
VL 43
IS 4
BP 1128
EP 1133
DI 10.1021/es8024116
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 406MC
UT WOS:000263298600029
PM 19320169
ER
PT J
AU Barnabe, S
Brar, SK
Tyagi, RD
Beauchesne, I
Surampalli, RY
AF Barnabe, S.
Brar, S. K.
Tyagi, R. D.
Beauchesne, I.
Surampalli, R. Y.
TI Pre-treatment and bioconversion of wastewater sludge to value-added
products-Fate of endocrine disrupting compounds
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Review
DE Endocrine disrupting compounds; Toxic intermediates; Wastewater sludge;
Pre-treatment; Bioconversion; Value added products
ID POLYCYCLIC AROMATIC-HYDROCARBONS; PERSONAL CARE PRODUCTS;
BACILLUS-THURINGIENSIS BIOPESTICIDES; MESOPHILIC ANAEROBIC-DIGESTION;
ALKYLBENZENE SULFONATES LAS; DIBENZO-P-DIOXINS; SEWAGE-SLUDGE;
PHTHALATE-ESTERS; RAW-MATERIAL; ACTIVATED-SLUDGE
AB Development of processes for the production of value added products (VAPs), such as biopesticides, microbial inoculants or industrial enzymes through biotransformation of raw or pre-treated wastewater sludge (WWS) has undergone a substantial progress over the last decade. WWS based VAPs are low cost biological alternatives that can compete with chemicals or other cost intensive biological products in the current markets. However, when WWS is used as a raw material for VAPs production, questions still remains on the persistence of organic pollutants within the biotransformed WWS, especially, endocrine disrupting compounds (EDCs) and the production of their toxic intermediates. WWS pretreatment prior to biotransformation as well as the microbial strains used for biotransformation can possibly remove these organic pollutants. The literature findings concerning the impact of WWS pre-treatment and value added products on EDCs removal are reviewed in this paper. The microbial potential to degrade or detoxify EDCs and toxic intermediates concomitant with value-addition is also discussed. The concept of obtaining EDCs free-WWS based VAPs and simultaneously achieving the objective of pollution control is presented. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Barnabe, S.; Brar, S. K.; Tyagi, R. D.; Beauchesne, I.] Univ Quebec, Inst Natl Rech Sci, Quebec City, PQ G1K 9A9, Canada.
[Surampalli, R. Y.] US EPA, Kansas City, KS 66117 USA.
RP Brar, SK (reprint author), Univ Quebec, Inst Natl Rech Sci, 490 Rue Couronne, Quebec City, PQ G1K 9A9, Canada.
EM satinder.brar@ete.inrs.ca
FU Natural Sciences and Engineering Research Council of Canada [A4984,
355254, STP235071]; INRS-ETE
FX The authors are sincerely thankful to the Natural Sciences and
Engineering Research Council of Canada (Discovery Grants A4984 and
355254, STP235071, Canada Research Chair) and INRS-ETE for financial
support. The views or opinions expressed in this article are those of
the authors and should not be construed as opinions of the U.S.
Environmental Protection Agency.
NR 171
TC 24
Z9 27
U1 3
U2 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0048-9697
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD FEB 15
PY 2009
VL 407
IS 5
BP 1471
EP 1488
DI 10.1016/j.scitotenv.2008.11.015
PG 18
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 416FI
UT WOS:000263990600001
PM 19110297
ER
PT J
AU Swartz, CD
King, LC
Nesnow, S
Umbach, DM
Kumar, S
DeMarini, DM
AF Swartz, Carol D.
King, Leon C.
Nesnow, Stephen
Umbach, David M.
Kumar, Subodh
DeMarini, David M.
TI Mutagenicity, stable DNA adducts, and abasic sites induced in Salmonella
by phenanthro[3,4-b]- and phenanthro[4,3-b]thiophenes, sulfur analogs of
benzo[c]phenanthrene
SO MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
LA English
DT Article
DE Mutagenicity; Salmonella; Sulfur-PAH; DNA adducts
ID REGION DIOL-EPOXIDES; MULTIPLE PATHWAYS; LIVER-MICROSOMES; HETEROCYCLES;
METABOLISM; CHROMATOGRAPHY; BIOACTIVATION; DIHYDRODIOLS; CHRYSENE;
DAMAGE
AB Sulfur-containing polycyclic aromatic hydrocarbons (thia-PAHs or thiaarenes) are common constituents of air pollution and cigarette smoke, but only a few have been studied for health effects. We evaluated the mutagenicity in Salmonella TA98, TA100, and TA104 of two sulfur-containing derivatives of benzo[c]phenanthrene, phenanthro[3,4-b]thiophene (P[3,4-b]T), and phenanthro[4,3-b]thiophene (P[4,3-b]T) as well as their dihydrodiol and sulfone derivatives. In addition, we assessed levels of stable DNA adducts (by (32)P-postlabeling) as well as abasic sites (by an aldehydic-site assay) produced by six of these compounds in TA100. P[3,4-b]T and its 6,7- and 8,9-diols, P[3,4-b]T sulfone, P[4,3-b]T, and its 8,9-diol were mutagenic in TA100. P[3,4-b]T sulfone, the most potent mutagen, was approximately twice as potent as benzo[a]pyrene in both TA98 and TA100. Benzo-ring dihydrodiols were much more potent than K-region dihydrodiols, which had little or no mutagenic activity in any strain. P[3,4-b]T sulfone produced abasic sites and not stable DNA adducts; the other five compounds examined, B[c]P, B[c]P 3,4-diol, P[3,4-b]T, P[3,4-b]T 8,9-diol, and P[4,3-b]T 8,9-diol, produced only stable DNA adducts. P[3,4-b]T sulfone was the only compound that produced significant levels of frameshift mutagenicity and induced mutations primarily at GC sites. In contrast, B[c]P, its 3,4-diol, and the 8,9 diols of the phenanthrothiophenes induced mutations primarily at AT sites. P[3,4-b]T was not mutagenic in TA104, whereas P[3,4-b]T sulfone was. The two isomeric forms (P[3,4-b]T and P[4,3-b]T) are apparently activated differently, with the latter, but not the former, involving a diol pathway. This study is the first illustrating the potential importance of abasic sites in the mutagenicity of thia-PAHs. Published by Elsevier B,V.
C1 [King, Leon C.; Nesnow, Stephen; DeMarini, David M.] US EPA, Div Environm Carcinogenesis, Res Triangle Pk, NC 27711 USA.
[Swartz, Carol D.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA.
[Umbach, David M.] NIEHS, Biostat Branch, NIH, DHHS, Res Triangle Pk, NC 27709 USA.
[Kumar, Subodh] SUNY Coll Buffalo, Environm Toxicol & Chem Lab, Great Lakes Ctr, Buffalo, NY 14222 USA.
RP DeMarini, DM (reprint author), US EPA, Div Environm Carcinogenesis, Res Triangle Pk, NC 27711 USA.
EM demarini.david@epa.gov
FU NHEERL-DESE Cooperative Training Agreement in Environmental Science
Research [US EPA CT 82651301]; Phillip Morris USA; NIH; National
Institute of Environmental Health Sciences; National Health and
Environmental Effects Research Laboratory, U.S. Environmental Protection
Agency,
FX We thank Peggy Matthews for preparation of medium and Linda Adams and
Joycelyn Allison for help with the DNA adduct analyses. We thank Jeffrey
Ross, Larry Claxton, and Daniel Shaughnessy for helpful comments on the
manuscript. The authors declare that they have no conflicts of interest.
C.D.S. was supported by a grant from the NHEERL-DESE Cooperative
Training Agreement in Environmental Science Research, US EPA CT
82651301. S.K. acknowledges support from Phillip Morris USA. This work
was also supported in part by the Intramural Research Program of the
NIH, National Institute of Environmental Health Sciences. This
manuscript has been reviewed by the National Health and Environmental
Effects Research Laboratory, U.S. Environmental Protection Agency, and
approved for publication. Approval does not signify that the contents
reflect the views of the Agency, nor does mention of trade names or
commercial products constitute endorsement or recommendation for use.
NR 29
TC 12
Z9 12
U1 1
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0027-5107
J9 MUTAT RES-FUND MOL M
JI Mutat. Res.-Fundam. Mol. Mech. Mutagen.
PD FEB 10
PY 2009
VL 661
IS 1-2
BP 47
EP 56
DI 10.1016/j.mrfmmm.2008.11.001
PG 10
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 410WO
UT WOS:000263609200007
PM 19041882
ER
PT J
AU Adams, WA
Impellitteri, CA
AF Adams, William A.
Impellitteri, Christopher A.
TI The photocatalysis of N,N-diethyl-m-toluamide (DEET) using dispersions
of Degussa P-25 TiO2 particles
SO JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
LA English
DT Article
DE N,N-Diethyl-m-toluamide; DEET; Titanium dioxide; Photocatalysis; Humic
acid
ID WASTE-WATER CONTAMINANTS; PERSONAL CARE PRODUCTS; INSECT REPELLENT DEET;
DRINKING-WATER; PHARMACEUTICAL COMPOUNDS; SURFACE-WATER; HUMIC ACIDS; US
STREAMS; DEGRADATION; OXIDATION
AB The photocatalysis of N,N-diethyl-meta-toluamide (DEET) was examined using aqueous Degussa P-25 TiO2 dispersions and a 350 nm Hg lamp UV reactor. Various concentrations of humic acid (HA) were added to the photocatalytic sample matrix in order to simulate the influence of natural organic matter (NOM) present during water treatment. A municipal secondary treatment effluent was also used as a sample matrix to provide a field sample comparison with laboratory matrixes. Pseudo-first-order kinetic rate constants were calculated for each set of samples. Gas chromatography/mass spectrometry (GC/MS) results showed a marked decrease in the photocatalytic degradation of DEET after the addition of HA. which continued to decrease with increasing HA concentration. The rate of degradation was further reduced after the addition of the municipal secondary treatment effluent, likely due to competition from dissolved organic matter and surface interference from soluble salts. Published by Elsevier B.V.
C1 [Adams, William A.; Impellitteri, Christopher A.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Adams, WA (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM adams.william@epa.gov
NR 42
TC 14
Z9 14
U1 1
U2 12
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1010-6030
J9 J PHOTOCH PHOTOBIO A
JI J. Photochem. Photobiol. A-Chem.
PD FEB 5
PY 2009
VL 202
IS 1
BP 28
EP 32
DI 10.1016/j.jphotochem.2008.11.003
PG 5
WC Chemistry, Physical
SC Chemistry
GA 409IS
UT WOS:000263500000004
ER
PT J
AU Cisneros, GA
Perera, L
Schaaper, RM
Pedersen, LC
London, RE
Pedersen, LG
Darden, TA
AF Cisneros, G. Andres
Perera, Lalith
Schaaper, Roel M.
Pedersen, Lars C.
London, Robert E.
Pedersen, Lee G.
Darden, Thomas A.
TI Reaction Mechanism of the epsilon Subunit of E-coli DNA Polymerase III:
Insights into Active Site Metal Coordination and Catalytically
Significant Residues
SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Article
ID FAMILIAL CHILBLAIN LUPUS; TRANSFER-RNA SYNTHETASE; MINIMUM-ENERGY PATHS;
HOT GENE-PRODUCT; CHEMICAL-REACTIONS; PROOFREADING EXONUCLEASE; ENZYME
CATALYSIS; STRUCTURAL BASIS; THETA-SUBUNIT; COMPLEX
AB The 28 kDa epsilon subunit of Escherichia coli DNA polymerase III is the exonucleotidic proofreader responsible for editing polymerase insertion errors. Here, we study the mechanism by which E carries out the exonuclease activity. We performed quantum mechanics/molecular mechanics calculations on the N-terminal domain containing the exonuclease activity. Both the free-E and a complex E bound to a 0 homologue (HOT) were studied. For the epsilon-HOT complex Mg2+ or Mn2+ were investigated as the essential divalent metal cofactors, while only Mg2+ was used for free-e. In all calculations a water molecule bound to the catalytic metal acts as the nucleophile for hydrolysis of the phosphate bond. Initially, a direct proton transfer to H162 is observed. Subsequently, the nucleophilic attack takes place followed by a second proton transfer to E14. Our results show that the reaction catalyzed with Mn2+ is faster than that with Mg2+, in agreement with experiment. In addition, the E-HOT complex shows a slightly lower energy barrier compared to free-E. In all cases the catalytic metal is observed to be pentacoordinated. Charge and frontier orbital analyses suggest that charge transfer may stabilize the pentacoordination. Energy decomposition analysis to study the contribution of each residue to catalysis suggests that there are several important residues. Among these, H98, D103, D129, and D146 have been implicated in catalysis by mutagenesis studies. Some of these residues were found to be structurally conserved on human TREX1, the exonuclease domains from E. coli DNA-Pol 1, and the DNA polymerase of bacteriophage RB69.
C1 [Cisneros, G. Andres; Perera, Lalith; Pedersen, Lars C.; London, Robert E.; Pedersen, Lee G.; Darden, Thomas A.] Natl Inst Environm Hlth Sci, Struct Biol Lab, Res Triangle Pk, NC 27709 USA.
[Schaaper, Roel M.] Natl Inst Environm Hlth Sci, Genet Mol Lab, Res Triangle Pk, NC 27709 USA.
RP Cisneros, GA (reprint author), Natl Inst Environm Hlth Sci, Struct Biol Lab, Res Triangle Pk, NC 27709 USA.
EM cisnero1@niehs.nih.gov; pereral2@niehs.nih.gov
RI pedersen, lee/A-8567-2009; Cisneros, Gerardo/B-3128-2010; perera,
Lalith/B-6879-2012; Pedersen, Lee/E-3405-2013
OI perera, Lalith/0000-0003-0823-1631; Pedersen, Lee/0000-0003-1262-9861
FU NIH; NIEHS [Z01 ES09060111]; NIH [HL-06350]; NSF [FRG/DMR-0804549]
FX This research was supported by the intramural research program of the
NIH and NIEHS Z01 ES09060111. L.G.P. acknowledges support from NIH
HL-06350 and NSF FRG/DMR-0804549. Computing-time from the NIEHS and UNC
computing facilities are gratefully acknowledged. G.A.C. thanks Drs. J.
M. Parks and H. Hu and Prof. W. Yang from Duke University and Prof. Y.
Zhang from NYU.
NR 76
TC 31
Z9 32
U1 1
U2 13
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0002-7863
J9 J AM CHEM SOC
JI J. Am. Chem. Soc.
PD FEB 4
PY 2009
VL 131
IS 4
BP 1550
EP 1556
DI 10.1021/ja8082818
PG 7
WC Chemistry, Multidisciplinary
SC Chemistry
GA 427PS
UT WOS:000264791800052
PM 19119875
ER
PT J
AU Oczkowski, AJ
Nixon, SW
Granger, SL
El-Sayed, AFM
McKinney, RA
AF Oczkowski, Autumn J.
Nixon, Scott W.
Granger, Stephen L.
El-Sayed, Abdel-Fattah M.
McKinney, Richard A.
TI Anthropogenic enhancement of Egypt's Mediterranean fishery
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE fisheries; Nile delta; nutrient enrichment; stable isotope
ID NILE DELTA; NITROGEN; RIVER; SEA
AB The highly productive coastal Mediterranean fishery off the Nile River delta collapsed after the completion of the Aswan High Dam in 1965. But the fishery has been recovering dramatically since the mid-1980s, coincident with large increases in fertilizer application and sewage discharge in Egypt. We use stable isotopes of nitrogen (delta N-15) to demonstrate that 60%-100% of the current fishery production may be from primary production stimulated by nutrients from fertilizer and sewage runoff. Although the establishment of the dam put Egypt in an ideal position to observe the impact of rapid increases in nutrient loading on coastal productivity in an extremely oligotrophic sea, the Egyptian situation is not unique. Such anthropogenically enhanced fisheries also may occur along the northern rim of the Mediterranean and offshore of some rapidly developing tropical countries, where nutrient concentrations in the coastal waters were previously very low.
C1 [Oczkowski, Autumn J.; Nixon, Scott W.; Granger, Stephen L.] Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA.
[El-Sayed, Abdel-Fattah M.] Univ Alexandria, Fac Sci, Dept Oceanog, Alexandria, Egypt.
[McKinney, Richard A.] US EPA, Atlantic Ecol Div, Narragansett, RI 02882 USA.
RP Oczkowski, AJ (reprint author), Univ Rhode Isl, Grad Sch Oceanog, Narragansett, RI 02882 USA.
EM ajo@gso.uri.edu
OI Oczkowski, Autumn/0000-0002-2421-0956
FU National Science Foundation (NSF) Biological Oceanography Program;
U.S.-Egypt Joint Board Junior Scientist Development Visit Grant;
National Oceanic and Atmospheric Administration (NOAA) Dr. Nancy Foster
Scholarship
FX This work was supported by a grant from the National Science Foundation
(NSF) Biological Oceanography Program (to S.W.N. and A.J.O.), a
U.S.-Egypt Joint Board Junior Scientist Development Visit Grant (to
A.J.O.), and a National Oceanic and Atmospheric Administration (NOAA)
Dr. Nancy Foster Scholarship (to A.J.O). The statements, findings,
conclusions, and recommendations herein are those of the authors and do
not necessarily reflect the views of NSF, NOAA, or the Department of
Commerce. We thank E. Merchant and T. Heywood for help with sample
processing and A. Salem, M. Gomaa, and M. Elnakib for help in sample
collection. Helpful comments were provided by M. E. Q. Pilson, C.
Oviatt, B. Fry, G. Lewis, B. Peterson, and 2 anonymous reviewers.
NR 29
TC 19
Z9 20
U1 0
U2 25
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD FEB 3
PY 2009
VL 106
IS 5
BP 1364
EP 1367
DI 10.1073/pnas.0812568106
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 403HV
UT WOS:000263074600016
PM 19164510
ER
PT J
AU Wu, YH
Walker, J
Schwede, D
Peters-Lidard, C
Dennis, R
Robarge, W
AF Wu, Yihua
Walker, John
Schwede, Donna
Peters-Lidard, Christa
Dennis, Robin
Robarge, Wayne
TI A new model of bi-directional ammonia exchange between the atmosphere
and biosphere: Ammonia stomatal compensation point
SO AGRICULTURAL AND FOREST METEOROLOGY
LA English
DT Article
DE Ammonia; Deposition; Emission; Compensation point; Modeling;
Bi-directional flux; Soybean
ID DRY DEPOSITION MODEL; OILSEED RAPE; APOPLASTIC NH4+; GRADIENT
MEASUREMENTS; GLUTAMINE-SYNTHETASE; BARLEY PLANTS; NH3 EXCHANGE; BARE
SOIL; LEAVES; NITROGEN
AB A new multi-layer canopy resistance model of bi-directional NH(3) exchange is presented. This new model, which is based on the Multi-Layer BioChemical deposition (MLBC) model [Wu, Y., Brashers, B., Finkelstein, P.L., Pleim, J.E., 2003a. A multiplayer biochemical dry deposition model. I. model formulation. J. Geophys. Res. 108, D1; Wu, Y., Brashers, B., Finkelstein, P.L., Pleim, J.E., 2003b. A multiplayer biochemical dry deposition model. II. Model evaluation. J. Geophys. Res. 108, D1], incorporates a parameterization for the ammonia stomatal compensation point that is theoretically derived to consider the effects of leaf temperature and apoplastic concentrations of NH(4)(+) and H(+). The new ammonia stomatal compensation point scheme accounts for the effects of deposition, emission and leaf temperature on the dynamics of apoplast [NH(4)(+)] and [H(+)]. The new model is evaluated against bidirectional NH(3) fluxes measured over fertilized soybean. The general patterns of observed deposition and emission are successfully reproduced when the ammonia stomatal compensation point is included. Driven by the effects of deposition, emission and leaf temperature, modeled apoplastic [NH(4)(+)] and [H(+)] display significant diurnal variation when the buffer effect of the underlying metabolic processes generating or consuming NH(4)(+) were ignored. Model predictive capability is improved slightly by incorporating the feedback into a dynamic stomatal compensation point. A simple implementation of the feedback mechanism in the current model provides opportunities for improvement. While the stomatal flux is shown to be an important process in the regulation of canopy-scale fluxes, it appears that exchange with leaf surface water and soil may also be important. Published by Elsevier B.V.
C1 [Wu, Yihua] Univ Maryland Baltimore Cty, Goddard Earth Sci & Technol Ctr, Greenbelt, MD 20771 USA.
[Walker, John] US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Schwede, Donna; Dennis, Robin] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Peters-Lidard, Christa] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
[Robarge, Wayne] N Carolina State Univ, Dept Soil Sci, Raleigh, NC 27695 USA.
RP Wu, YH (reprint author), NOAA, NCEP, EMC, 5200 Auth Rd, Camp Springs, MD 20746 USA.
EM Yihua.Wu@noaa.gov
RI Peters-Lidard, Christa/E-1429-2012; Walker, John/I-8880-2014
OI Peters-Lidard, Christa/0000-0003-1255-2876; Walker,
John/0000-0001-6034-7514
NR 68
TC 20
Z9 20
U1 2
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1923
J9 AGR FOREST METEOROL
JI Agric. For. Meteorol.
PD FEB
PY 2009
VL 149
IS 2
BP 263
EP 280
DI 10.1016/j.agrformet.2008.08.012
PG 18
WC Agronomy; Forestry; Meteorology & Atmospheric Sciences
SC Agriculture; Forestry; Meteorology & Atmospheric Sciences
GA 397TH
UT WOS:000262684500006
ER
PT J
AU Carroll, M
Radcliffe, E
MacRae, I
Ragsdale, D
Olson, K
Badibanga, T
AF Carroll, Matthew W.
Radcliffe, Edward B.
MacRae, Ian V.
Ragsdale, David W.
Olson, Kent D.
Badibanga, Thaddee
TI Border Treatment to Reduce Insecticide Use in Seed Potato Production:
Biological, Economic, and Managerial Analysis
SO AMERICAN JOURNAL OF POTATO RESEARCH
LA English
DT Article
DE Targeted applications; Myzus persicae; Methamidophos; Green peach aphid
ID MANAGEMENT
AB Worldwide, Myzus persicae (Sulzer) is considered the key vector of Potato leafroll virus (PLRV). In the northern Great Plains, introduction of PLRV into seed potato fields is coincident with mid-summer dispersal of winged M. persicae from local crop and weed hosts. Initial colonization of potato fields tends to occur at field margins. In 2003, experiments were conducted in 23 seed potato fields to evaluate effectiveness of targeted methamidophos applications for M. persicae control. These applications provided excellent control (> 94%) of colonizing aphids in the borders, slowed subsequent within field spread, and necessitated treatment of 95% fewer hectares than would treating entire fields. Across entire fields, control costs averaged $4.22 per ha for border treatments compared to a hypothetical $58.91 per ha for applying methamidophos to entire fields. Thus targeted insecticide applications can provide effective M. persicae control in seed potato fields while greatly lowering insecticide use and application costs overall.
C1 [Carroll, Matthew W.] US EPA, ORD, NRMRL, STD,SEB, Cincinnati, OH 45268 USA.
[Radcliffe, Edward B.; MacRae, Ian V.; Ragsdale, David W.] Univ Minnesota, Dept Entomol, St Paul, MN 55108 USA.
[Olson, Kent D.; Badibanga, Thaddee] Univ Minnesota, Dept Appl Econ, St Paul, MN 55108 USA.
RP Carroll, M (reprint author), US EPA, ORD, NRMRL, STD,SEB, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM carroll.matthew@epa.gov
FU U. S. Environmental Protection Agency
FX This research was sponsored by American Farmland Trust Center for
Agriculture in the Environment and funded in part by U. S. Environmental
Protection Agency. We are grateful for the cooperation of the seed
potato growers who participated in this project. Collectively, the
acreage they entered into this experiment represented more than 4.6% of
the total Minnesota and North Dakota seed potato acreage certified in
2003. We thank Gregg Halverson, President and CEO of Black Gold for his
permission to use information on Black Gold's pest management practices.
We also thank Robert Suranyi, Willem Schrage, Jeff Davis, Erin Hladilek,
and all the undergraduate field workers who helped make this project a
success.
NR 18
TC 6
Z9 7
U1 1
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1099-209X
J9 AM J POTATO RES
JI Am. J. Potato Res.
PD FEB
PY 2009
VL 86
IS 1
BP 31
EP 37
DI 10.1007/s12230-008-9058-7
PG 7
WC Agronomy
SC Agriculture
GA 403FX
UT WOS:000263069600004
ER
PT J
AU Barzyk, TM
George, BJ
Vette, AF
Williams, RW
Croghan, CW
Stevens, CD
AF Barzyk, Timothy M.
George, Barbara Jane
Vette, Alan F.
Williams, Ronald W.
Croghan, Carry W.
Stevens, Carvin D.
TI Development of a distance-to-roadway proximity metric to compare
near-road pollutant levels to a central site monitor
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Near-road; VOC; Effective distance; Central site monitor
ID VOLATILE ORGANIC-COMPOUNDS; PARTICULATE AIR-POLLUTION; AMBIENT
NITROGEN-DIOXIDE; RESPIRATORY HEALTH; ULTRAFINE PARTICLES; MAJOR ROAD;
SIZE DISTRIBUTION; UNITED-KINGDOM; MAIN ROADS; EXPOSURE
AB The primary objective of the Detroit Exposure and Aerosol Research Study (DEARS) was to compare air pollutant concentrations measured at various neighborhoods, or exposure monitoring areas (EMAs), throughout a major metropolitan area to levels measured at a central site or community monitor. One of the EMAs was located near a busy freeway (annual average daily traffic (AADT) of similar to 130,000) so that impacts of mobile sources could be examined, Air pollution concentrations from the roadway-proximate sites were compared to the central site monitor. The volatile organic compounds (VOCs) selected (benzene, toluene, ethylbenzene, m,p- and o-xylene, 1,3 butadiene, 13,5-trimethylbenzene and 4-ethyltoluene) are typically associated with mobile sources. Gradients were also evident that demonstrated the amplification of pollutant levels near the roadway compared to the community monitor. A novel distance-to-roadway proximity metric was developed to plot the measurements and model these gradients. Effective distance represents the actual distance an air parcel travels from the middle of a roadway to a site and varies as a function of wind direction, whereas perpendicular distance is a fixed distance oriented normal to the roadway. Perpendicular distance is often used as a proxy for exposures to traffic emissions in epidemiological Studies.
Elevated concentrations of all the compounds were found for both a Summer and winter season. Effective distance was found to be a statistically significant (p < 0.05) univariate predictor for concentrations of toluene, ethylbenzene, m,p-xylene and o-xylene for Summer 2005. For each of these pollutants, effective distance yielded lower p-values than the corresponding perpendicular distance models, and model fit improved. Results demonstrate that this near-road EMA had elevated levels of traffic-related VOCs compared to the community monitor, and that effective distance was a more accurate predictor of the degree to which they were elevated as a function of distance. Effective distance produced a range of distance-to-roadway Values for a single site based on wind direction, thus increasing the number and range of values that Could be used to plot and predict relative differences in Pollutant concentrations between two sites. Published by Elsevier Ltd.
C1 [Barzyk, Timothy M.; George, Barbara Jane; Vette, Alan F.; Williams, Ronald W.; Croghan, Carry W.; Stevens, Carvin D.] US EPA, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Barzyk, TM (reprint author), US EPA, Natl Exposure Res Lab, 109 Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM barzyk.timothy@epa.gov
RI Vette, Alan/A-7330-2012
OI Vette, Alan/0000-0001-6749-1252
NR 48
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Z9 21
U1 2
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD FEB
PY 2009
VL 43
IS 4
BP 787
EP 797
DI 10.1016/j.atmosenv.2008.11.002
PG 11
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 404YE
UT WOS:000263188100004
ER
PT J
AU Geron, C
AF Geron, Chris
TI Carbonaceous aerosol over a Pinus taeda forest in Central North
Carolina, USA
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Organic carbon; Particulate matter; Southeastern US; Biogenic VOC;
Biomass burning; Secondary organic aerosol
ID SECONDARY ORGANIC AEROSOL; UNITED-STATES; PARTICULATE MATTER; ELEMENTAL
CARBON; ALPHA-PINENE; AIR; ATMOSPHERE; EMISSIONS; HUMIDITY; OZONE
AB Organic aerosol is the least understood component of ambient fine particulate matter (PM(2.5)). In this study, organic and elemental carbon (OC and EC) within ambient PM(2.5) over a three-year period at a forested site in the North Carolina Piedmont are presented. EC exhibited significant weekday/weekend effects and less significant seasonal effects, in contrast to OC, which showed strong seasonal differences and smaller weekend/weekday effects. Summer OC concentrations are about twice as high as winter concentrations, while EC was somewhat higher in the winter. OC was highly correlated with EC during cool periods when both were controlled by primary combustion sources. This correlation decreased with increasing temperature, reflecting higher contributions from secondary organic aerosol, likely of biogenic origin. PM(2.)5 radiocarbon data from the site confirms that a large fraction of the carbon in PM(2.5) is indeed of biogenic origin, since modern (non-fossil fuel derived) carbon accounted for 80% of the PM(2.5) carbon over the course of a year. OC and EC exhibited distinct diurnal profiles, with summertime OC peaking in late evening and declining until midday, During winter, DC peaked during the early morning hours and again declined until midday. Summertime EC peaked during late morning hours except on weekends. Wintertime EC often peaked in late PM or early AM hours due to local residential wood combustion emissions. The highest short term peaks in OC and EC were associated with wildfire events. These data corroborate recent source apportionment Studies conducted within 20 km of our site, where oxidation products of isoprene, alpha-pinene, and beta-caryophyllene were identified as important precursors to organic aerosols. A large fraction of the carbon in rural southeastern ambient PM(2.5), appears to be of biogenic origin, which is probably difficult to reduce by anthropogenic controls. Published by Elsevier Ltd.
C1 US EPA, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
RP Geron, C (reprint author), US EPA, Natl Risk Management Res Lab, Mail Drop E305-02,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM geron.chris@epa.gov
OI Geron, Chris/0000-0002-4266-2155
FU Office of Science (BER), U.S. Department of Energy [DE-FG02-95ER62083];
Brookhaven National Laboratory [DE-AC02-98CH10886]
FX I thank Dave Smith of Sunset Laboratories for his technical assistance
with the Sunset OC/EC analyzer. Dr. John Offenberg of EPA NERL performed
off-line OC/EC analysis of the Hi-vol samples and provided helpful
insight during the study. Mike McClure of EPA NRMRL provided assistance
in developing standards for the Sunset OC/EC instrument. Dr. John I
Walker of EPA NRMRL assisted in the development of the meteorological
database Used in this study. Carol Shay Lenox and Carly Carroll of EPA
NRMRL were very helpful in managing the aethalometer data. Dr. Wayne
Cornelius of the North Carolina Department of Air Quality provided
regional air quality data from Burlington, Caswell County, Durham, and
Raleigh. His expertise and assistance is greatly appreciated. This
research was supported by the Office of Science (BER), U.S. Department
of Energy, Grant No. DE-FG02-95ER62083. Meteorological data were
obtained under the U.S. Department of Energy Contract No.
DE-AC02-98CH10886 with Brookhaven National Laboratory.
NR 28
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U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD FEB
PY 2009
VL 43
IS 4
BP 959
EP 969
DI 10.1016/j.atmosenv.2008.10.053
PG 11
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 404YE
UT WOS:000263188100024
ER
PT J
AU Swall, JL
Foley, KM
AF Swall, Jenise L.
Foley, Kristen M.
TI The impact of spatial correlation and incommensurability on model
evaluation
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Block kriging; Air quality modeling; Spatial interpolation; Statistical
simulation
ID NUMERICAL-MODELS; CMAQ
AB Standard evaluations of air quality models rely heavily on a direct comparison of monitoring data matched with the model output for the grid cell containing the monitor's location. While such techniques may be adequate for some applications, conclusions are limited by such factors as the sparseness of the available observations (limiting the number Of grid cells at which the model can be evaluated) and the incommensurability between volume-averages and pointwise observations. We examine several sets of simulations to illustrate the effect of incommensurability in a Variety of cases distinguished by the type and extent of spatial correlation present. Block kriging, a statistical method which can be used to address the issue, is then demonstrated using the simulations. Lastly, we apply this method to actual data and discuss the practical importance Of understanding the impact of spatial correlation structure and incommensurability. Published by Elsevier Ltd.
C1 [Swall, Jenise L.; Foley, Kristen M.] US EPA, Atmospher Modeling Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
RP Swall, JL (reprint author), US EPA, Atmospher Modeling Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
EM swall.jenise@epa.gov; foley.kristen@epa.gov
OI Swall, Jenise/0000-0001-8728-5771
NR 18
TC 17
Z9 17
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD FEB
PY 2009
VL 43
IS 6
BP 1204
EP 1217
DI 10.1016/j.atmosenv.2008.10.057
PG 14
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 408HR
UT WOS:000263426600006
ER
PT J
AU Hagler, GSW
Baldauf, RW
Thoma, ED
Long, TR
Snow, RF
Kinsey, JS
Oudejans, L
Gullett, BK
AF Hagler, G. S. W.
Baldauf, R. W.
Thoma, E. D.
Long, T. R.
Snow, R. F.
Kinsey, J. S.
Oudejans, L.
Gullett, B. K.
TI Ultrafine particles near a major roadway in Raleigh, North Carolina:
Downwind attenuation and correlation with traffic-related pollutants
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Ultrafine particles; Air toxics; Carbon monoxide; Traffic emissions;
Gradient
ID PARTICULATE MATTER EMISSIONS; COMPOSITION DISTRIBUTIONS; SUBMICROMETER
PARTICLES; SIZE; VEHICLES; TRANSLOCATION; HIGHWAYS; EXPOSURE; NUMBER;
FINE
AB Ultrafine particles (UFPs, diameter < 100 nm) and co-emitted pollutants from traffic are a potential health threat to nearby populations. During summertime in Raleigh, North Carolina UFPs were simultaneously measured upwind and downwind of a major roadway using a spatial matrix of five portable industrial hygiene samplers (measuring total counts of 20-1000 run particles). While the upper sampling range of the Portable samplers extends past the defined "ultrafine" upper limit (100 nm), the 201000 nm number counts had high Correlation (Pearson R = 0.7-0.9) with UFPs; (10-70 nm) measured by a co-located research-grade analyzer and thus appear to be driven by the Ultrafine range. Highest UFP concentrations were observed during weekday morning work commutes, with levels at 20 m downwind from the road nearly fivefold higher than at an upwind station. A strong downwind spatial gradient was observed, linearly approximated over the first 100 in as an 8% drop in UFP Counts per 10 in distance. This result agreed well with UFP spatial gradients estimated from past studies (ranging 5-12% drop per 10 in). Linear regression of other vehicle-related air Pollutants measured in near real-time (10-min averages) against UFPs yielded moderate to high correlation with benzene (R(2) = 0.76), toluene (R(2) = 0.49), carbon monoxide (R(2) = 0.74), nitric oxide (R(2) = 0.80), and black carbon (R(2) = 0.65). Overall, these results support the notion that near-road levels of UFPs are heavily influenced by traffic emissions and correlate with other vehicle-produced Pollutants, including certain air toxics. Published by Elsevier Ltd.
C1 [Hagler, G. S. W.; Baldauf, R. W.; Thoma, E. D.; Long, T. R.; Kinsey, J. S.; Gullett, B. K.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA.
[Baldauf, R. W.] US EPA, Off Air & Radiat, Off Transportat & Air Qual, Natl Vehicle & Fuel Emiss Lab, Ann Arbor, MI USA.
[Snow, R. F.; Oudejans, L.] ARCADIS, Res Triangle Pk, NC USA.
RP Hagler, GSW (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM hagler.gayle@epa.gov
RI Kinsey, John/A-8335-2009
FU U.S. EPA's National Program; EPA Advanced Monitoring Initiative Grant;
North Carolina Lions Club for the Blind; ARCADIS
FX This research would not be possible without the support of a large
number of individuals within the EPA. The authors are grateful for the
leadership and Support from Dan Costa, U.S. EPA's National Program
Director for Air. This research received funding assistance from the EPA
Advanced Monitoring Initiative Grant and field access from the North
Carolina Lions Club for the Blind. In addition, the authors wish to
thank Edgar Thompson, Bill Mitchell, Jason Weinstein, Sue Kimbrough, and
Bruce Harris in the EPA Office of Research and Development for their
contributions to this Study. Finally we are grateful to ARCADIS
employees Eric Morris, Tom Balicki, and Ram Hashmonay for critical
project implementation support.
NR 25
TC 90
Z9 91
U1 0
U2 24
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD FEB
PY 2009
VL 43
IS 6
BP 1229
EP 1234
DI 10.1016/j.atmosenv.2008.11.024
PG 6
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 408HR
UT WOS:000263426600008
ER
PT J
AU Wang, HQ
Jacob, DJ
Le Sager, P
Streets, DG
Park, RJ
Gilliland, AB
van Donkelaar, A
AF Wang, Huiqun
Jacob, Daniel J.
Le Sager, Philippe
Streets, David G.
Park, Rokjin J.
Gilliland, Alice B.
van Donkelaar, A.
TI Surface ozone background in the United States: Canadian and Mexican
pollution influences
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Background ozone; Surface ozone; Air quality standard; Chemical
transport model; Global model
ID TROPOSPHERIC OZONE; NORTH-AMERICA; AIR-QUALITY; VARIABILITY; EMISSIONS;
TRANSPORT; SATELLITE; CHEMISTRY; AIRCRAFT; METHANE
AB We use a global chemical transport model (GEOS-Chem) with 1 degrees x 1 degrees horizontal resolution to quantify the effects of anthropogenic emissions from Canada, Mexico, and outside North America on daily maximum 8-hour average ozone concentrations in US surface air. Simulations for summer 2001 indicate mean North American and US background concentrations of 26 +/- 8 ppb and 30 +/- 8 ppb, as obtained by eliminating anthropogenic emissions in North America vs. in the US only. The US background never exceeds 60 ppb in the model. The Canadian and Mexican pollution enhancement averages 3 +/- 4 ppb in the US in summer but can be occasionally much higher in downwind regions of the northeast and southwest, peaking at 33 ppb in upstate New York (on a day with 75 ppb total ozone) and 18 ppb in southern California (on a day with 68 ppb total ozone). The model is successful in reproducing the observed variability of ozone in these regions, including the occurrence and magnitude of high-ozone episodes influenced by transboundary pollution. We find that exceedances of the 75 ppb US air quality standard in eastern Michigan, western New York, New Jersey, and southern California are often associated with Canadian and Mexican pollution enhancements in excess of 10 ppb. Sensitivity simulations with 2020 emission projections suggest that Canadian pollution influence in the Northeast US will become comparable in magnitude to that from domestic power plants. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Wang, Huiqun; Jacob, Daniel J.; Le Sager, Philippe] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
[Streets, David G.] Argonne Natl Lab, Argonne, IL 60439 USA.
[Park, Rokjin J.] Seoul Natl Univ, Sch Earth & Environm Sci, Seoul, South Korea.
[Gilliland, Alice B.] US EPA, Off Res & Dev, Natl Exposure Res Lab, Atmospher Modeling Div, Washington, DC USA.
[van Donkelaar, A.] Dalhousie Univ, Dept Phys & Atmospher Sci, Halifax, NS, Canada.
RP Wang, HQ (reprint author), Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.
EM hwang@cfa.harvard.edu
RI Chem, GEOS/C-5595-2014; Park, Rokjin/I-5055-2012;
OI Park, Rokjin/0000-0001-8922-0234; Streets, David/0000-0002-0223-1350
FU US Department of Energy; Office of Fossil Energy; Argonne National
Laboratory
FX This work was sponsored by US Department of Energy, Office of Fossil
Energy, through a contract with Argonne National Laboratory. We thank
Naresh Kumar at EPRI and Thomas Grahame at DOE for their constructive
input to this work.
NR 28
TC 52
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U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
EI 1873-2844
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD FEB
PY 2009
VL 43
IS 6
BP 1310
EP 1319
DI 10.1016/j.atmosenv.2008.11.036
PG 10
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 408HR
UT WOS:000263426600018
ER
PT J
AU McNyset, KM
AF McNyset, Kristina M.
TI Ecological niche conservatism in North American freshwater fishes
SO BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY
LA English
DT Article
DE GARP; predictive modeling
ID PHYLOGENETIC-RELATIONSHIPS; BLACK BASSES; SPECIATION; PREDICTION;
TELEOSTEI; PHYLOGEOGRAPHY; ACTINOPTERYGII; DISTRIBUTIONS; CENTRARCHIDAE;
SYSTEMATICS
AB There are many hypotheses of relationships, and also of speciation processes, in North American freshwater fishes, although, to date, there have been no direct tests of whether there is evidence of ecological niche conservatism. In the present study, ecological niche modeling is used to look for evidence of ecological niche conservatism in six clades of freshwater fishes: the starheaded topminnows, sand darters, black basses, Notropis rubellus species group, Notropis longirostris species group, and the Hybopsis amblops species group. This is achieved by evaluating the reciprocal predictivity of distributional predictions based on ecological niche models developed for each individual taxon in a clade under the assumption that high reciprical predictivity between sister species can be taken as evidence of niche conservatism. Omission percentages, total and average commission, and the area under the curve in a receiver operating characteristic analysis, where calculated, are used to evaluate predictive ability. Occurrence data for each species were subset into a training and independent validation data set where possible. Across all clades and species, models predicted the validation data for a given species well. Ecological niche conservatism was found generally across the starheaded topminnows, the sand darters, and the N. longirostris species group. There was some inter-predictivity within the N. rubellus group, but almost no inter-predictivity within the black basses, indicating a lack of conservatism. These results demonstrate that ecological niches generally act as stable constraints on freshwater fish distributions in North America. (C) 2009 The Linnean Society of London, Biological Journal of the Linnean Society, 2009, 96, 282-295.
C1 US EPA, Off Res & Dev, Western Ecol Div, Corvallis, OR 97333 USA.
RP McNyset, KM (reprint author), US EPA, Off Res & Dev, Western Ecol Div, 200 SW 35th St, Corvallis, OR 97333 USA.
EM krismcn@gmail.com
NR 48
TC 13
Z9 13
U1 1
U2 18
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0024-4066
J9 BIOL J LINN SOC
JI Biol. J. Linnean Soc.
PD FEB
PY 2009
VL 96
IS 2
BP 282
EP 295
DI 10.1111/j.1095-8312.2008.01121.x
PG 14
WC Evolutionary Biology
SC Evolutionary Biology
GA 397AU
UT WOS:000262635000003
ER
PT J
AU Scott, LLF
Staskal, DF
Williams, ES
Luksemburg, WJ
Urban, JD
Nguyen, LM
Haws, LC
Birnbaum, LS
Paustenbach, DJ
Harris, MA
AF Scott, Laura L. F.
Staskal, Daniele F.
Williams, E. Spencer
Luksemburg, William J.
Urban, Jon D.
Nguyen, Ly M.
Haws, Laurie C.
Birnbaum, Linda S.
Paustenbach, Dennis J.
Harris, Mark A.
TI Levels of polychlorinated dibenzo-p-dioxins, dibenzofurans, and
biphenyls in southern Mississippi catfish and estimation of potential
health risks
SO CHEMOSPHERE
LA English
DT Article
DE Dioxin; PCDDs; PCDFs; PCBs; Biomonitoring; Fish
ID UNITED-STATES; CONTAMINANTS; FISH; PCBS; REEVALUATION; BENEFITS; COOKING
AB Fish consumption has been classified as one of the primary pathways of exposure to polychlorinated dibenzo-p-dioxins, dibenzofurans (PCDD/Fs) and biphenyls (PCBs). In this study, we evaluated tissue levels of the 17 laterally substituted PCDD/Fs, 12 dioxin-like PCBs, and 97 non-dioxin-like PCBs in a number of wild-caught and farm-raised cat fish collected throughout southern Mississippi. Total lipid-adjusted TEQ and non-dioxin-like PCB concentrations in wild-caught cat fish fillets were significantly higher than concentrations in farm-raised fillet samples. The percent contribution of PCDDs, PCDFs, and dioxin-like PCBs to mean total TEQ varied between wild-caught and farm-raised samples as well as by collection site for wild-caught cat fish. The non-dioxin-like PCBs that contributed the most to total PCB concentrations also differed between wild-caught and farm-raised samples. Regardless of whether samples were farm-raised or wild-caught, estimated cancer risks associated with consumption of these cat fish were less than 27.0E-06. Overall, results of this study indicate that levels of dioxin-like compounds and PCBs in Mississippi cat fish are similar to those measured in more recent studies in the US and that levels of these compounds appear to be decreasing in this food source. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Scott, Laura L. F.; Williams, E. Spencer; Nguyen, Ly M.; Harris, Mark A.] ChemRisk, Houston, TX 77042 USA.
[Staskal, Daniele F.; Urban, Jon D.; Haws, Laurie C.] ChemRisk, Austin, TX USA.
[Luksemburg, William J.] Vista Analyt Lab, El Dorado Hills, CA USA.
[Birnbaum, Linda S.] US EPA, Res Triangle Pk, NC 27711 USA.
[Paustenbach, Dennis J.] ChemRisk, San Francisco, CA USA.
RP Scott, LLF (reprint author), ChemRisk, 10375 Richmond Ave,Suite 350, Houston, TX 77042 USA.
EM lscott@chemrisk.com
OI harris, mark/0000-0002-9007-1587
FU Joslyn Manufacturing, Inc.; Liberty Mutual; ChemRisk, Inc.; Vista
Analytical Laboratory
FX We would like to thank the local anglers of southern Mississippi for
their efforts in helping us obtain cat fish for this study. Thanks are
also given to Ken Unice for his help with data quality veri. cation and
Andrew Tachovsky for his expertise in GIS. Funding for the analyses
described in this paper was provided in part by Joslyn Manufacturing,
Inc. and Liberty Mutual. Additional funding was provided by ChemRisk,
Inc. and Vista Analytical Laboratory. The contents of this paper reflect
the opinions and view of the authors and do not represent the official
views of the USEPA. The mention of trade names or commercial products
does not constitute endorsement or recommendation for use.
NR 39
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
J9 CHEMOSPHERE
JI Chemosphere
PD FEB
PY 2009
VL 74
IS 7
BP 1002
EP 1010
DI 10.1016/j.chemosphere.2008.09.090
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 418XE
UT WOS:000264182400019
PM 19108868
ER
PT J
AU Glaser, J
AF Glaser, John A.
TI Right to food and agrofuels
SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY
LA English
DT News Item
C1 US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Glaser, J (reprint author), US EPA, Natl Risk Management Res Lab, 26 W King Dr, Cincinnati, OH 45268 USA.
EM Glaser.John@epa.gov
NR 0
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U1 0
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PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1618-954X
J9 CLEAN TECHNOL ENVIR
JI Clean Technol. Environ. Policy
PD FEB
PY 2009
VL 11
IS 1
BP 11
EP 14
DI 10.1007/s10098-008-0192-1
PG 4
WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental;
Environmental Sciences
SC Science & Technology - Other Topics; Engineering; Environmental Sciences
& Ecology
GA 407JD
UT WOS:000263358500003
ER
PT J
AU Lu, G
Dolgner, SJ
Hall, TMT
AF Lu, Gang
Dolgner, Stephen J.
Hall, Traci M. Tanaka
TI Understanding and engineering RNA sequence specificity of PUF proteins
SO CURRENT OPINION IN STRUCTURAL BIOLOGY
LA English
DT Article
ID PUMILIO-HOMOLOGY DOMAIN; MESSENGER-RNA; BINDING-SPECIFICITY; FAMILY;
YEAST; LOCALIZATION; TRANSLATION
AB PUF proteins are RNA-binding proteins named for founding members PUMILIO and fem-3 binding factor (FBF). Together these proteins represent the range of known RNA recognition properties. PUMILIO is a prototypical PUF protein whose RNA sequence specificity is simple, elegant, and predictable. FBF displays differences in RNA recognition that represent divergence from the prototype. Here we review recent studies that examine the engineering of sequence specificity of PUF proteins and its applications as well as studies that increase our understanding of the natural diversity of RNA recognition by this family of proteins.
C1 [Lu, Gang; Dolgner, Stephen J.; Hall, Traci M. Tanaka] Natl Inst Environm Hlth Sci, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP Lu, G (reprint author), Natl Inst Environm Hlth Sci, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.
EM lug@niehs.nih.gov; dolgn001@mc.duke.edu; hall4@niehs.nih.gov
FU National Institute of Environmental Health Sciences
FX We are grateftil to our colleagLICS for critical reading ofthis
manLiScript and 11 Cacioppo of the NJ EHS Arts and Photography grOLIP
for graphics design. 'Fhis work was supported by the Intramural escarch
Program of the National InStitLlteS of Health, National Institute of
Environmental Health Sciences.
NR 21
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PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0959-440X
J9 CURR OPIN STRUC BIOL
JI Curr. Opin. Struct. Biol.
PD FEB
PY 2009
VL 19
IS 1
BP 110
EP 115
DI 10.1016/j.sbi.2008.12.009
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 420IH
UT WOS:000264282000017
PM 19186050
ER
PT J
AU Wasko, BM
Holland, CL
Resnick, MA
Lewis, LK
AF Wasko, Brian M.
Holland, Cory L.
Resnick, Michael A.
Lewis, L. Kevin
TI Inhibition of DNA double-strand break repair by the Ku heterodimer in
mrx mutants of Saccharomyces cerevisiae
SO DNA REPAIR
LA English
DT Article
DE Telomerase; Exonuclease; DNA repair; End-joining; Homologous
recombination
ID YEAST TELOMERASE RNA; HOMOLOGOUS RECOMBINATION; CHECKPOINT ACTIVATION;
GENOME STABILITY; MRE11 COMPLEX; PROTEIN; MAINTENANCE; INTERACTS;
COMPONENT; DAMAGE
AB Yeast rad50 and mre11 nuclease mutants are hypersensitive to physical and chemical agents that induce DNA double-strand breaks (DSBs). This sensitivity was suppressed by elevating intracellular levels of TLC1, the RNA subunit of telomerase. Suppression required proteins linked to homologous recombination, including Rad51. Rad52, Rad59 and Exo1. but not genes of the nonhomologous end-joining (NHEJ) repair pathway. Deletion mutagenesis experiments demonstrated that the 5'-end of TLC1 RNA was essential and a segment containing a binding site for the Yku70/Yku80 complex was sufficient for suppression. A mutant TLC1 RNA unable to associate with Yku80 protein did not increase resistance. These and other genetic studies indicated that association of the Ku heterodimer with broken DNA ends inhibits recombination in mrx mutants. but not in repair-proficient cells or in other DNA repair single mutants. In support of this model, DNA damage resistance of mrx cells was enhanced when YKU70 was co-inactivated. Defective recombinational repair of DSBs in mrx cells thus arises from at least two separate processes: loss of Mrx nuclease-associated DNA end-processing and inhibition of the Exo1-mediated secondary recombination pathway by Ku. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Wasko, Brian M.; Holland, Cory L.; Lewis, L. Kevin] Texas State Univ, Dept Chem & Biochem, San Marcos, TX 78666 USA.
[Resnick, Michael A.] Natl Inst Environm Hlth Sci, Mol Genet Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP Lewis, LK (reprint author), Texas State Univ, Dept Chem & Biochem, 601 Univ Dr, San Marcos, TX 78666 USA.
EM LL18@txstate.edu
FU Research Corporation [CC5767]; National Institutes of Health
[1R15AG02852001A1]
FX The authors wish to thank Dan Gottschling and Nancy Kleckner for gifts
of plasmids and Shanna Calero for expert technical assistance. KL was
supported in part by Research Corporation grant CC5767 and National
Institutes of Health Grant 1R15AG02852001A1.
NR 52
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U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1568-7864
J9 DNA REPAIR
JI DNA Repair
PD FEB 1
PY 2009
VL 8
IS 2
BP 162
EP 169
DI 10.1016/j.dnarep.2008.09.010
PG 8
WC Genetics & Heredity; Toxicology
SC Genetics & Heredity; Toxicology
GA 405GU
UT WOS:000263211900004
PM 18992851
ER
PT J
AU Ghanayem, BI
Bai, R
Burka, LT
AF Ghanayem, Burhan I.
Bai, Re
Burka, Leo T.
TI Effect of Dose Volume on the Toxicokinetics of Acrylamide and Its
Metabolites and 2-Deoxy-D-glucose
SO DRUG METABOLISM AND DISPOSITION
LA English
DT Article
ID URINARY METABOLITES; CYTOCHROME-P450 2E1; MALE-MICE; GLYCIDAMIDE;
GENOTOXICITY; CYP2E1-NULL; DNA
AB Acrylamide (AA) is a known mutagen and animal carcinogen. Comparison of recent studies revealed significant quantitative differences in AA-induced germ cell mutagenicity. It was hypothesized that despite the administration of AA at similar doses, the discrepancy in the observed effects was most likely due to varying AA concentrations in the administered dosing solution. To test this hypothesis, AA was administered i.p. to mice at 50 mg/kg in a dose volume of 5 or 50 ml/kg, blood was collected at various time points, and AA and its metabolites were quantitated. Changes in dose volume resulted in significant differences in the toxicokinetics of AA and its metabolites and suggested that increased C(max) of AA led to increased metabolism. This theory, in conjunction with the fact that higher levels of AA-derived radioactivity were detected in the testes, may explain the greater toxicity of a 50 mg/kg dose when administered in 5 versus 50 ml/kg. The impact of dose volume on the toxicokinetics of 2-deoxy-D-glucose (DG), a nonreactive, nonmetabolizable substance, was also investigated. The areas under the curve for DG were not different for the two dose volumes; however, C(max) for the more concentrated dose was significantly higher. In conclusion, current studies show that the toxicokinetics of an administered xenobiotic and its metabolites is influenced by the concentration of the parent chemical in the dosing solution. Therefore, it is important to consider the concentration of an administered xenobiotic in the dosing solution because it may affect its toxicokinetics and metabolism and subsequently affect the biological effects of the administered chemical.
C1 [Ghanayem, Burhan I.; Bai, Re; Burka, Leo T.] Natl Inst Environm Hlth Sci, Pharmacol Lab, NIH, Res Triangle Pk, NC 27709 USA.
RP Ghanayem, BI (reprint author), Natl Inst Environm Hlth Sci, Pharmacol Lab, NIH, Res Triangle Pk, NC 27709 USA.
EM Ghanayem@niehs.nih.gov
FU Intramural Research Program of the National Institutes of Health
National Institute of Environmental Health Sciences
FX This work was supported by the Intramural Research Program of the
National Institutes of Health National Institute of Environmental Health
Sciences.
NR 19
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U1 0
U2 5
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0090-9556
J9 DRUG METAB DISPOS
JI Drug Metab. Dispos.
PD FEB
PY 2009
VL 37
IS 2
BP 259
EP 263
DI 10.1124/dmd.108.024265
PG 5
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 396WV
UT WOS:000262623000003
PM 19022940
ER
PT J
AU Hoehle, SI
Knudsen, GA
Sanders, JM
Sipes, IG
AF Hoehle, Simone I.
Knudsen, Gabriel A.
Sanders, J. Michael
Sipes, I. Glenn
TI Absorption, Distribution, Metabolism, and Excretion of
2,2-Bis(bromomethyl)-1,3-propanediol in Male Fischer-344 Rats
SO DRUG METABOLISM AND DISPOSITION
LA English
DT Article
ID TETRABROMOBISPHENOL-A; FLAME-RETARDANT; F344/N RATS; DISPOSITION;
CARCINOGENICITY; GLUCURONIDATION; IDENTIFICATION; ACETAMINOPHEN; MICE
AB 2,2-Bis(bromomethyl)-1,3-propanediol (BMP) is a brominated flame retardant, previously shown to be a multisite carcinogen in experimental animals. Studies were performed to characterize the dispositional and metabolic fate of BMP after oral or intravenous administration to male Fischer-344 rats. After a single oral administration of [(14)C] BMP (10 or 100 mg/kg) >80% of the low dose and 48% of the high dose were excreted by 12 h in the urine predominantly as a glucuronide metabolite. After repeated daily oral doses for 5 or 10 days, route and rate of elimination were similar to those obtained after single administrations of BMP. In all studies, the radioactivity recovered in feces was low (<15%). The total amount of radioactivity remaining in tissues at 72 h after a single oral administration of BMP (100 mg/kg) was less than 1% of the dose, and repeated daily dosing did not lead to retention in tissues. After intravenous administration, the radiolabel found in blood decreased rapidly. Excretion profiles were similar to those after oral administration. Parent BMP and BMP glucuronide were present in blood plasma after oral or intravenous dosing. After an intravenous dose of BMP (15 mg/kg) the hepatic BMP glucuronide was primarily exported into the bile (>50% within 6 h), but it underwent enterohepatic recycling with subsequent elimination in the urine. These data indicate that the extensive extraction and rapid glucuronidation by the liver limits exposure of internal tissues to BMP by greatly reducing its systemic bioavailability after oral exposure.
C1 [Hoehle, Simone I.; Knudsen, Gabriel A.; Sipes, I. Glenn] Univ Arizona, Coll Med, Dept Pharmacol, Tucson, AZ 85724 USA.
[Sanders, J. Michael] Natl Inst Environm Hlth Sci, Lab Pharmacol & Chem, Natl Toxicol Program, Res Triangle Pk, NC USA.
RP Sipes, IG (reprint author), Univ Arizona, Coll Med, Dept Pharmacol, POB 245050, Tucson, AZ 85724 USA.
EM sipes@email.arizona.edu
RI Knudsen, Gabriel/G-3706-2013
OI Knudsen, Gabriel/0000-0002-7208-6451
FU National Toxicology Program/National Institute of Environmental Health
Science (NIEHS) [N01-ES-45529]; National Institutes of Health; NIEHS;
Southwest Environmental Health Science Center [P30-ES06694]
FX This work was supported by the National Toxicology Program/National
Institute of Environmental Health Science (NIEHS) (Contract
N01-ES-45529) and in part by the Intramural Research Program of the
National Institutes of Health and NIEHS. We also acknowledge support
provided by the Analytical Core of the NIEHS-funded Southwest
Environmental Health Science Center [Grant P30-ES06694].
NR 22
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U1 1
U2 10
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0090-9556
J9 DRUG METAB DISPOS
JI Drug Metab. Dispos.
PD FEB
PY 2009
VL 37
IS 2
BP 408
EP 416
DI 10.1124/dmd.108.023937
PG 9
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 396WV
UT WOS:000262623000024
PM 19029203
ER
PT J
AU Ge, ZF
AF Ge, Zhongfu
TI Effectiveness of the T-test in Multiple Linear Regression Modeling of
Environmental Systems
SO ENVIRONMENTAL ENGINEERING SCIENCE
LA English
DT Article
DE significance; model selection; orthonormal; Cp; multicollinearity
ID BEACH CLOSURES; LAKE-MICHIGAN; ECOLOGY
AB In previous works that used multiple linear regression (MLR) modeling, some researchers tended to extend the t-test results on the full model to infer a generalized conclusion that some explanatory variables influence the response more significantly than others. We found through a model re-parameterization that such generalization is only valid when the transformed design matrix is orthonormal, in which case the resulting t-ratios of the full model have a consistent order for the entire system (all reduced models). Otherwise, for practical data sets, t-ratios are all interdependent and subjected to changes in reduced models. Significance of the variables inferred from the full model therefore has no general meaning about the physics of the environmental system. In observation of the restriction of the t-test to a single model and the frequent need for deducing a general comparison of variable significance in environmental research, the significance test for explanatory variables can be conducted by a model selection process with, for example, Mallows' Cp, Akaike's Information Criterion (AIC), or Bayesian Information Criterion (BIC), which are insensitive to the orthonormality of the transformed design matrix, as the selection criterion. Once the parsimonious model is identified, the variables in the parsimonious model can be considered to be significant for the response. This is a general inference about the significance of the explanatory variables, which is consistent for the entire system.
C1 US EPA, Natl Res Council, Ecosyst Res Div, Athens, GA 30605 USA.
RP Ge, ZF (reprint author), US EPA, Natl Res Council, Ecosyst Res Div, 960 Coll Stn Rd, Athens, GA 30605 USA.
EM gezhfu@yahoo.com
FU National Academies of the United States
FX The author would like to thank Mike Cyterski of EPA for the helpful
discussions. This work also partially benefited from the research
associateship programs of the National Academies of the United States.
NR 19
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U1 0
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PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1092-8758
J9 ENVIRON ENG SCI
JI Environ. Eng. Sci.
PD FEB
PY 2009
VL 26
IS 2
BP 377
EP 383
DI 10.1089/ees.2008.0014
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 403BP
UT WOS:000263057100016
ER
PT J
AU Rao, ST
Steyn, DG
Kallos, G
AF Rao, S. T.
Steyn, Douw G.
Kallos, George
TI Physics-Chemistry interactions in the atmosphere from the air quality
perspective
SO ENVIRONMENTAL FLUID MECHANICS
LA English
DT Editorial Material
C1 [Rao, S. T.] US EPA, Atmospher Modeling Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA.
[Steyn, Douw G.] Univ British Columbia, Dept Earth & Ocean Sci, Atmospher Sci Program, Vancouver, BC V6T 1Z4, Canada.
[Kallos, George] Univ Athens, Sch Phys, Div Environm & Meteorol, Athens 15784, Greece.
RP Rao, ST (reprint author), US EPA, Atmospher Modeling Div, Natl Exposure Res Lab, 109 T Alexander Dr,Room E-240D, Res Triangle Pk, NC 27711 USA.
EM rao.st@epa.gov
NR 0
TC 1
Z9 1
U1 0
U2 5
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1567-7419
J9 ENVIRON FLUID MECH
JI Environ. Fluid Mech.
PD FEB
PY 2009
VL 9
IS 1
BP 1
EP 2
DI 10.1007/s10652-009-9120-0
PG 2
WC Environmental Sciences; Mechanics; Meteorology & Atmospheric Sciences;
Oceanography; Water Resources
SC Environmental Sciences & Ecology; Mechanics; Meteorology & Atmospheric
Sciences; Oceanography; Water Resources
GA 416AG
UT WOS:000263977000001
ER
PT J
AU Neuberger, JS
Hu, SC
Drake, KD
Jim, R
AF Neuberger, John S.
Hu, Stephen C.
Drake, K. David
Jim, Rebecca
TI Potential health impacts of heavy-metal exposure at the Tar Creek
Superfund site, Ottawa County, Oklahoma
SO ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
LA English
DT Article
CT Conference of the Society-for-Environmental-Geochemistry-and-Health on
Urban Geochemistry and Health
CY JUL 22-25, 2007
CL New Orleans, LA
SP Soc Environm Geochem & Hlth
DE Hazardous wastes; Health studies; Lead; Mining wastes; Superfund site
ID MINING COMMUNITY; NATIVE-AMERICAN; BLOOD LEAD; CHILDREN; CADMIUM; ZINC;
BIOAVAILABILITY; MORTALITY; WASTE; AREA
AB The potential impact of exposure to heavy metals and health problems was evaluated at the Tar Creek Superfund site, Ottawa County, Oklahoma, USA. Observed versus expected mortality was calculated for selected conditions in the County and exposed cities. Excess mortality was found for stroke and heart disease when comparing the exposed County to the state but not when comparing the exposed cities to the nonexposed rest of the County. However, sample sizes in the exposed area were small, population emigration has been ongoing, and geographic coding of mortality data was incomplete. In an exposed community, 62.5% of children under the age of 6 years had blood lead levels exceeding 10 mu g/dl. The relationships between heavy-metal exposure and children's health and chronic disease in adults are suggestive that a more thorough investigation might be warranted. A number of possible environmental and health studies are suggested, including those focusing on possible central nervous system impacts. Unfortunately, the exposed population is dispersing. One lesson learned at this site is that health studies need to be conducted as soon as possible after an environmental problem is identified to both study the impact of the most acute exposures and to maximize study sample size-including those exposed to higher doses-and minimize the loss of individuals to follow-up.
C1 [Neuberger, John S.] Univ Kansas, Sch Med, Dept Prevent Med & Publ Hlth, Kansas City, KS 66160 USA.
[Hu, Stephen C.] Green Hosp, Scripps Clin, La Jolla, CA 92037 USA.
[Drake, K. David] US EPA, Kansas City, KS 66101 USA.
[Jim, Rebecca] LEAD Agcy, Vinita, OK 74301 USA.
RP Neuberger, JS (reprint author), Univ Kansas, Sch Med, Dept Prevent Med & Publ Hlth, Mail Stop 1008,3901 Rainbow Blvd, Kansas City, KS 66160 USA.
EM jneuberg@kumc.edu; Hu.Stephen@scrippshealth.org;
Drake.Dave@epamail.epa.gov; rjim@neok.com
NR 44
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U1 0
U2 16
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0269-4042
J9 ENVIRON GEOCHEM HLTH
JI Environ. Geochem. Health
PD FEB
PY 2009
VL 31
IS 1
BP 47
EP 59
DI 10.1007/s10653-008-9154-0
PG 13
WC Engineering, Environmental; Environmental Sciences; Public,
Environmental & Occupational Health; Water Resources
SC Engineering; Environmental Sciences & Ecology; Public, Environmental &
Occupational Health; Water Resources
GA 389IR
UT WOS:000262086600004
PM 18306045
ER
PT J
AU White, RH
Cote, I
Zeise, L
Fox, M
Dominici, F
Burke, TA
White, PD
Hattis, DB
Samet, JM
AF White, Ronald H.
Cote, Ila
Zeise, Lauren
Fox, Mary
Dominici, Francesca
Burke, Thomas A.
White, Paul D.
Hattis, Dale B.
Samet, Jonathan M.
TI State-of-the-Science Workshop Report: Issues and Approaches in
Low-Dose-Response Extrapolation for Environmental Health Risk Assessment
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE dose-response function; environmental health; low-dose extrapolation;
risk assessment; workshop report
ID CHEMICAL CARCINOGENESIS; FRAMEWORK; RELEVANCE; MODE
AB Low-dose extrapolation model selection for evaluating the health effects of environmental pollutants is a key component of the risk assessment process. At a workshop held in Baltimore, Maryland, on 23-24 April 2007, sponsored by U.S. Environmental Protection Agency and Johns Hopkins Risk Sciences and Public Policy Institute, a multidisciplinary group of experts reviewed the state of the science regarding low-dose extrapolation modeling and its application in environmental health risk assessments. Participants identified discussion topics based on a literature review, which included examples for which human responses to ambient exposures have been extensively characterized for cancer and/or noncancer outcomes. Topics included the need for formalized approaches and criteria to assess the evidence for mode of action (MOA), the use of human versus animal data, the use of MOA information in biologically based models, and the implications of interindividual variability, background disease processes, and background exposures in threshold Versus nonthreshold model choice. Participants recommended approaches that differ from current practice for extrapolating high-dose animal data to low-dose human exposures, including categorical approaches for integrating information on MOA, statistical approaches such as model averaging, and inference-based models that explicitly consider uncertainty and interindividual variability.
C1 [White, Ronald H.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Risk Sci & Publ Policy Inst, Baltimore, MD 21205 USA.
[Cote, Ila] US EPA, Res Triangle Pk, NC USA.
[Zeise, Lauren] Calif Environm Protect Agcy, Off Environm Hlth Hazard Assessment, Sacramento, CA USA.
[White, Paul D.] US EPA, Washington, DC 20460 USA.
[Hattis, Dale B.] Clark Univ, Worcester, MA 01610 USA.
RP White, RH (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Risk Sci & Publ Policy Inst, 615 N Wolfe St,Room W6035, Baltimore, MD 21205 USA.
EM rwhite@jhsph.edu
NR 24
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U1 1
U2 10
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD FEB
PY 2009
VL 117
IS 2
BP 283
EP 287
DI 10.1289/ehp.11502
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA 401VO
UT WOS:000262970700039
PM 19270800
ER
PT J
AU Kalin, L
Hantush, MM
AF Kalin, Latif
Hantush, Mohamed M.
TI An Auxiliary Method to Reduce Potential Adverse Impacts of Projected
Land Developments: Subwatershed Prioritization
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Hydrologic model; Pocono Creek; SWAT; Watershed; Urbanization;
Sustainability; Source prioritization
ID URBANIZATION; STREAM; URBAN; UNCERTAINTY; HABITAT; EROSION
AB An index based method is developed that ranks the subwatersheds of a watershed based on their relative impacts on watershed response to anticipated land developments, and then applied to an urbanizing watershed in Eastern Pennsylvania. Simulations with a semi-distributed hydrologic model show that computed low- and high-flow frequencies at the main outlet increase significantly with the projected landscape changes in the watershed. The developed index is utilized to prioritize areas in the urbanizing watershed based on their contributions to alterations in the magnitude of selected flow characteristics at two spatial resolutions. The low-flow measure, 7Q10, rankings are shown to mimic the spatial trend of groundwater recharge rates, whereas average annual maximum daily flow, (Q) over bar (AMAX), and average monthly median of daily flows, (Q) over bar (MMED), rankings are influenced by both recharge and proximity to watershed outlet. Results indicate that, especially with the higher resolution, areas having quicker responses are not necessarily the more critical areas for high-flow scenarios. Subwatershed rankings are shown to vary slightly with the location of water quality/quantity criteria enforcement. It is also found that rankings of subwatersheds upstream from the site of interest, which could be the main outlet or any interior point in the watershed, may be influenced by the time scale of the hydrologic processes.
C1 [Kalin, Latif] Auburn Univ, Sch Forestry & Wildlife Sci, Auburn, AL 36849 USA.
[Hantush, Mohamed M.] US EPA, Natl Risk Management & Res Lab, Cincinnati, OH 45268 USA.
RP Kalin, L (reprint author), Auburn Univ, Sch Forestry & Wildlife Sci, 602 Duncan Dr, Auburn, AL 36849 USA.
EM latif@auburn.edu
FU U. S. Environmental Protection Agency
FX The U. S. Environmental Protection Agency through its Office of Research
and Development partially funded and managed the research described here
through in-house efforts and in part by an appointment to the
Postgraduate Research Program at the National Risk Management Research
Laboratory administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the U. S. Department
of Energy and the U. S. Environmental Protection Agency. It has not been
subjected to Agency review and therefore does not necessarily reflect
the views of the Agency, and no official endorsement should be inferred.
NR 37
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U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
J9 ENVIRON MANAGE
JI Environ. Manage.
PD FEB
PY 2009
VL 43
IS 2
BP 311
EP 325
DI 10.1007/s00267-008-9202-7
PG 15
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 418UR
UT WOS:000264175400010
PM 18836760
ER
PT J
AU Costanza, J
Fletcher, KE
Loeffler, FE
Pennell, KD
AF Costanza, Jed
Fletcher, Kelly E.
Loeffler, Frank E.
Pennell, Kurt D.
TI Fate of TCE in Heated Fort Lewis Soil
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ABIOTIC DEGRADATION; SP-NOV; AQUIFER; TRICHLOROETHYLENE; DECHLORINATION;
BACTERIUM; SEDIMENTS; COLUMNS; METAL; IRON
AB This study explores the transformation of trichloroethene (TCE) caused by heating contaminated soil and groundwater samples obtained from the East Gate Disposal Yard (EGDY) located in Fort Lewis, WA. After field samples transferring into glass ampules and introducing 1.5 mu mol of TCE, the sealed ampules were incubated at temperatures of 25, 50, and 95 degrees C for periods of up to 95.5 days. Although TCE was completely transformed into cis-1,2-dichloroethene (cis-DCE) after 42 days at 25 degrees C by microbial activity, this transformation was not observed at 50 or 95 degrees C. Chloride levels increased after 42 days at 25 degrees C corresponding to the mass of TCE transformed to cis-DCE, were constant at 50 degrees C, and increased at 95 degrees C yielding a TCE degradation half-life of 1.6-1.9 years. These findings indicate that indigenous microbes contribute to the partial dechlorination of TCE to cis-DCE at temperatures of less than 50 degrees C, whereas interphase mass transfer and physical recovery of TCE will predominate over in situ degradation processes at temperatures of greater than 50 degrees C during thermal treatment at the EGDY site.
C1 [Fletcher, Kelly E.; Loeffler, Frank E.; Pennell, Kurt D.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA.
[Loeffler, Frank E.] Georgia Inst Technol, Sch Biol, Atlanta, GA 30332 USA.
RP Costanza, J (reprint author), US EPA, Washington, DC 20460 USA.
EM costanza.jed@epa.gov
RI Pennell, Kurt/F-6862-2010; Loeffler, Frank/M-8216-2013
OI Pennell, Kurt/0000-0002-5788-6397;
FU Strategic Environmental Research and Development Program (SERDP);
[W912HQ-05-C-008]; [ER-1419]
FX The authors thank Kyra P. Lynch and Jeff Powers, United States Corps of
Engineers, Seattle District, for providing access to soil and
groundwater samples, and W. Crawford Elliott (Georgia Sate University)
for assistance with XRD analysis. Support for this research was provided
by the Strategic Environmental Research and Development Program (SERDP)
under Contract W912HQ-05-C-008 for Project ER-1419, "Investigation of
Chemical Reactivity, Mass Recovery and Biological Activity During
Thermal Treatment of DNAPL". This work has not been subject to SERDP
review and no official endorsement should be inferred.
NR 21
TC 12
Z9 12
U1 1
U2 10
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD FEB 1
PY 2009
VL 43
IS 3
BP 909
EP 914
DI 10.1021/es802508x
PG 6
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 401FX
UT WOS:000262926400062
PM 19245035
ER
PT J
AU Agarwal, S
Al-Abed, SR
Dionysiou, DD
Graybill, E
AF Agarwal, Shirish
Al-Abed, Souhail R.
Dionysiou, Dionysios D.
Graybill, Eric
TI Reactivity of Substituted Chlorines and Ensuing Dechlorination Pathways
of Select PCB Congeners with Pd/Mg Bimetallics
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID DIBENZO-P-DIOXINS; POLYCHLORINATED-BIPHENYLS; REDUCTIVE DECHLORINATION;
ZEROVALENT IRON; HYDRODECHLORINATION; PALLADIUM; SYSTEMS; PARTICLES;
SEDIMENTS
AB Conflicting accounts occur on the reactivity of substituted chlorines and the ensuing dechlorination pathway of PCBs undergoing catalytic hydrodechlorination (HDCl). In order to understand these relationships, intermediates and dechlorination pathways of carefully selected 17 congeners were investigated with reactive Pd/Mg systems that bring about their rapid and complete dechlorination. The preferential site of electrophilic attack and its mechanistic aspects were interpreted in terms of steric, inductive, and resonance stabilization. The trends for electrophilic substitution were consistently p- > m- > o-positions indicating that more toxic "coplanar" PCB congeners were easily reduced. The dechlorination rates and pathways were influenced both by inductive effect of Cl that likely governs the stability of the intermediate arenium ion and by steric effects primarily effecting the adsorption step (especially for the o-congeners). Electrophilic attack occurred preferentially on the less substituted phenyl ring in absence of steric effects. A distinct correlation between rate of HDCl and the degree of chlorination was not observed, rather it depended on positions of Cl with respect to the biphenyl bond, and the dominance between counteracting factors of deactivation by subsequent chlorinations and improvement in probability of dechlorination through increased number of Cls.
C1 [Al-Abed, Souhail R.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Agarwal, Shirish; Dionysiou, Dionysios D.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA.
[Graybill, Eric] Pegasus Tech Serv Inc, Cincinnati, OH 45221 USA.
RP Al-Abed, SR (reprint author), US EPA, Natl Risk Management Res Lab, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA.
EM abed.souhail@epa.gov
NR 23
TC 29
Z9 31
U1 2
U2 16
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD FEB 1
PY 2009
VL 43
IS 3
BP 915
EP 921
DI 10.1021/es802538d
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 401FX
UT WOS:000262926400063
PM 19245036
ER
EF